WorldWideScience

Sample records for siqueiros quebrada discovery

  1. Mexican Muralists: Rivera, Siqueiros, and Orozco. Curriculum Projects. Fulbright-Hays Summer Seminars Abroad Program, 2002 (Mexico).

    Science.gov (United States)

    Walter, Kim

    Murals created by Diego Rivera, Jose Clemente Orozco, and David Alfaro Siqueiros embody a time of change in Mexico. The murals they created were intended to educate an illiterate population. Today these murals embody national pride. The goal of this curriculum project is rooted in learning about the history, culture, and art of Mexico. The project…

  2. Trace Elements in Basalts From the Siqueiros Fracture Zone: Implications for Melt Migration Models

    Science.gov (United States)

    Pickle, R. C.; Forsyth, D. W.; Saal, A. E.; Nagle, A. N.; Perfit, M. R.

    2008-12-01

    Incompatible trace element (ITE) ratios in MORB from a variety of locations may provide insights into the melt migration process by constraining aggregated melt compositions predicted by mantle melting and flow models. By using actual plate geometries to create a 3-D thermodynamic mantle model, melt volumes and compositions at all depths and locations may be calculated and binned into cubes using the pHMELTS algorithm [Asimow et al., 2004]. These melts can be traced from each cube to the surface assuming several migration models, including a simplified pressure gradient model and one in which melt is guided upwards by a low permeability compacted layer. The ITE ratios of all melts arriving at the surface are summed, averaged, and compared to those of the actual sample compositions from the various MOR locales. The Siqueiros fracture zone at 8° 20' N on the East Pacific Rise (EPR) comprises 4 intra-transform spreading centers (ITSCs) across 140 km of offset between two longer spreading ridges, and is an excellent study region for several reasons. First, an abundance of MORB data is readily available, and the samples retrieved from ITSCs are unlikely to be aggregated in a long-lived magma chamber or affected by along-axis transport, so they represent melts extracted locally from the mantle. Additionally, samples at Siqueiros span a compositional range from depleted to normal MORB within the fracture zone yet have similar isotopic compositions to samples collected from the 9-10° EPR. This minimizes the effect of assuming a uniform source composition in our melting model despite a heterogeneous mantle, allowing us to consistently compare the actual lava composition with that predicted by our model. Finally, it has been demonstrated with preliminary migration models that incipient melts generated directly below an ITSC may not necessarily erupt at that ITSC but migrate laterally towards a nearby ridge due to enhanced pressure gradients. The close proximity of the

  3. Changes through territorial windows. Quebrada de Humahuaca [Jujuy, Argentina

    Directory of Open Access Journals (Sweden)

    Constanza Inés Tommei

    2013-07-01

    Full Text Available The paper works on the redraw, construction and analysis of new maps and interpretations in some territorials windows, in various scales, for few urban centers of the Quebrada de Humahuaca (Jujuy, Argentina as an instrument of knowledge. In this sense, this research is looking to understand the morphological processes of transformation in recent decades, in relation to the economic crisis in Argentina at the beginning of the XXI century, the declaration of the Quebrada de Humahuaca as a World Heritage Site (UNESCO, 2003 and national tourism promotion, among other events that have changed the local’s logics. For this, study the changes and continuities in the territory and the types of urban development –adding new blocks, annexation of new neighborhoods and subdivisions in the urban discontinuous or gradual densification of urban, rural and rururban, among others– knowing the recent history of the Quebrada.

  4. A New Basal Sauropodomorph (Dinosauria: Saurischia) from Quebrada del Barro Formation (Marayes-El Carrizal Basin), Northwestern Argentina

    Science.gov (United States)

    Apaldetti, Cecilia; Martinez, Ricardo N.; Alcober, Oscar A.; Pol, Diego

    2011-01-01

    Background Argentinean basal sauropodomorphs are known by several specimens from different basins; Ischigualasto, El Tranquilo, and Mogna. The Argentinean record is diverse and includes some of the most primitive known sauropodomorphs such as Panphagia and Chromogisaurus, as well as more derived forms, including several massospondylids. Until now, the Massospondylidae were the group of basal sauropodomorphs most widely spread around Pangea with a record in almost all continents, mostly from the southern hemisphere, including the only record from Antarctica. Methodology/Principal Finding We describe here a new basal sauropodomorph, Leyesaurus marayensis gen. et sp. nov., from the Quebrada del Barro Formation, an Upper Triassic-Lower Jurassic unit that crops out in northwestern Argentina. The new taxon is represented by a partial articulated skeleton that includes the skull, vertebral column, scapular and pelvic girdles, and hindlimb. Leyesaurus is diagnosed by a set of unique features, such as a sharply acute angle (50 degrees) formed by the ascending process of the maxilla and the alveolar margin, a straight ascending process of the maxilla with a longitudinal ridge on its lateral surface, noticeably bulging labial side of the maxillary teeth, greatly elongated cervical vertebrae, and proximal articular surface of metatarsal III that is shelf-like and medially deflected. Phylogenetic analysis recovers Leyesaurus as a basal sauropodomorph, sister taxon of Adeopapposaurus within the Massospondylidae. Moreover, the results suggest that massospondylids achieved a higher diversity than previously thought. Conclusions/Significance Our phylogenetic results differ with respect to previous analyses by rejecting the massospondylid affinities of some taxa from the northern hemisphere (e.g., Seitaad, Sarahsaurus). As a result, the new taxon Leyesaurus, coupled with other recent discoveries, suggests that the diversity of massospondylids in the southern hemisphere was higher

  5. HIDROGEOLOGIA E HIDROGEOQUIMICA DE LA CUENCA DE LA QUEBRADA PAIPOTE, REGION DE ATACAMA

    OpenAIRE

    LORCA UGALDE, MARIA ELIANA DEL PILAR

    2011-01-01

    Hipótesis de Trabajo Las aguas de la cuenca de la quebrada Paipote tienen un origen meteórico y es posible que existan aportes de flujo subterráneo desde la cuenca del Salar de Maricunga. Objetivo General Generar un modelo hidrogeológico conceptual sobre la base del comportamiento hidráulico de las rocas y sedimentos, la calidad química de las aguas y a el balance hídrico de la cuenca de la quebrada Paipote. Objetivos Específicos Los objetivos específicos de este estudio son...

  6. VARIACIÓN MORFOLÓGICA CRANEOFACIAL EN POBLACIONES HUMANAS DE LA QUEBRADA DE HUMAHUACA (JUJUY, ARGENTINA / Morphological variation of human populations on Quebrada de Humahuaca (Jujuy, Argentina

    Directory of Open Access Journals (Sweden)

    Lumila Paula Menendez

    2014-11-01

    Full Text Available El propósito del presente trabajo fue analizar la variación morfológica craneofacial en poblaciones humanas que habitaron la Quebrada de Humahuaca durante el Holoceno tardío. Se estudiaron los cambios en forma y tamaño del esqueleto facial y base craneana, y se evaluó la distribución de la variación morfológica craneofacial en el espacio geográfico. Para esto, se seleccionaron 114 cráneos de individuos adultos de ambos sexos que no presentasen modificaciones culturales o las presentasen en un grado muy leve, procedentes de seis sitios del sector medio de la Quebrada. Se relevaron 41 puntos anatómicos en 3D con un brazo mecánico Microscribe G2X. Para evaluar la variación morfológica se realizó un ANOVA, se calcularon componentes principales y variables canónicas; mientras que la asociación entre morfología y variación espacial fue evaluada a través de un análisis de Procrustes. Los resultados indican que la variación craneofacial difiere según se considere el esqueleto facial ó la base. Dado que los mayores cambios se registraron en la región facial, la variación morfológica podría ser explicada como producto de la plasticidad fenotípica. Asimismo, no se encontró relación entre la variación morfológica y la distribución geográfica de las muestras. Palabras clave: Variación craneofacial, modificaciones culturales del cráneo, Quebrada de Humahuaca, Holoceno tardío.  Abstract The aim of this paper was to analyze the craniofacial morphological variation in human samples showing no cultural modifications of the skull, belonging to populations that lived in the Quebrada de Humahuaca during the late Holocene. Shape and size alterations of the facial skeleton and skull base were studied, and the spatial distribution of morphological variables was evaluated. For this purpose, 114 skulls of adult men and women with slight or absent cultural modifications, from six archaeological sites in the middle section of the

  7. Inventario de fuentes hídricas superficiales en la microcuenca de la quebrada Toromocho

    OpenAIRE

    Autoridad Nacional del Agua. Autoridad Administrativa del Agua VI Marañón

    2013-01-01

    Determina en forma cualitativa y cuantitativa las fuentes de agua superficial que comprenden los cursos de agua, manantiales, bofedales, almacenamientos (lagunas y represas) y otras fuentes naturales de agua superficial, en la microcuenca de la quebrada Toromocho. Cabe indicar que este estudio ha sido elaborado en el marco de la actividad "Inventario de recursos hídricos en las cabeceras de cuencas de los ríos Chirimayo, Chugurmayo, Jadibamba, Ñun Ñun (Toromocho) y Chailhuagón" realizada por ...

  8. Monitoreo de la reforestación en las quebradas en el Norte de Quito

    Directory of Open Access Journals (Sweden)

    Anita Argüello

    2012-12-01

    Full Text Available El Distrito Metropolitano de Quito (DMQ comprende 61.563 has., las cuales albergan diversasespecies de flora y fauna. Los procesos de acelerada urbanización han dado lugar alestablecimiento de viviendas e invasiones que han presionado a los bosques que existíanespecialmente en las laderas del Pichincha y en las quebradas de la parte norte del distrito. ElMunicipio del Distrito Metropolitano de Quito (MDMQ en sus Políticas de Patrimonio Natural,contempla la integración, conectividad, mantenimiento, recuperación, y rehabilitación deespacios naturales priorizados para seguridad ambiental del Distrito, cuya aplicación tienecomo objetivo específico el disminuir la afectación antrópica progresiva a ecosistemas yespacios naturales de conservación del Distrito. Con estos antecedentes se realiza unacontratación para la reforestación de once quebradas en la Administración Zonal La Delicia, lamisma que se realiza en los meses de abril – junio del presente año (2012 en un total de 43has. con el compromiso de siembra de 37.152 plantas. Para realizar el seguimiento a esteproceso se plantea un monitoreo inicial para conocer el estado de la reforestación y el impactocausado en las quebradas seleccionadas. Mediante recorridos y mapeo de sitio, se contabilizanlas plantas sembradas y supervivientes en cada una de las quebradas y se constata elcumplimiento de solo el 5,05% de la reforestación planteada.Abstract:The Metropolitan District of Quito covers 61.563 has., containing many species of flora andfauna. Accelerated urbanization processes have led to illegal housing and human invasions,putting pressure on existing forests, especially on the slopes of Pichincha and the ravines of thenorthern part of the District. The Metropolitan District of Quito, in its Natural Heritage Policy,prioritizes the integration, connectivity, maintenance, recovery and rehabilitation of naturalareas, to support the District environmental security. Focus is put on

  9. CALIDAD DEL AGUA DE LAS QUEBRADAS LA CRISTALINA Y LA RISARALDA, SAN LUIS, ANTIOQUIA

    Directory of Open Access Journals (Sweden)

    María Cecilia Arango

    2008-07-01

    Full Text Available Las quebradas La Cristalina y La Risaralda son las fuentes que abastecen el acueducto del área urbana del municipio de San Luis, Antioquia. El propósito de este estudio fue elaborar un mapa de calidad de agua que sirva como base de comparación de la evolución de las quebradas y justifique la inversión de los recursos del Municipio en el mejoramiento prioritario de los tramos más críticos. Para establecer la calidad del agua se determinaron indicadores físicos, químicos y biológicos, entre ellos algunas características físicas de las quebradas como tipo de sustrato, cobertura de riberas y hábitats acuáticos, temperatura, conductividad, oxígeno, pH, coliformes y macroinvertebrados acuáticos. A partir de los datos colectados se calcularon los índices BMWP/Col1, ASPT, ETP, índice de dípteros y de equidad. Con los resultados obtenidos del ASPT se construyó el mapa de calidad de agua para ambas quebradas. Las quebradas están bien oxigenadas debido a la turbulencia provocada por la conformación rocosa de su lecho, que a su vez permite la diversidad de macroinvertebrados acuáticos. Sin embargo, algunos tramos de estas corrientes están sometidos a contaminación de origen doméstico y agropecuario, lo cual limita sus condiciones de uso.The streams La Cristalina and La Risaralda are the water sources for the urban area of the Municipality of San Luis, Antioquia. The intention of this study was to develop a map of water quality that serves as base as comparison of the evolution of the streams and allows the high-priority destination of the resources of the Municipality in the improvement of those more critical sections. In order to determine the quality of the water, parameters and some characteristics of the stream that can alter the quality of the water were measured, like substrate of the bed, cover of banks, aquatic habitats, temperature, conductivity, oxygen, pH, coliforms, and aquatic macroinvertebrates. The indices calculated

  10. Impacto de la conquista inca en la metalurgia de Los Amarillos (Quebrada de Humahuaca, Jujuy

    Directory of Open Access Journals (Sweden)

    Carlos I. Angiorama

    2011-01-01

    Full Text Available En este trabajo analizamos el impacto de la conquista inca en la producción y circulación de objetos metálicos en el asentamiento conocido como Los Amarillos, uno de los más complejos de los localizados en la Quebrada de Humahuaca (Jujuy. Luego comparamos los resultados de nuestras investigaciones con los obtenidos por arqueometalurgos en otros lugares del país, demostrando que las repercusiones de la conquista incaica no han sido las mismas en todos los centros metalúrgicos de la región. Por el contrario, el Imperio reorganizó la producción y la circulación de objetos metálicos aplicando estrategias diferentes en los diversos casos estudiados.

  11. Creation of the Quebrada Arriba Community and Academic Partnership: An Effective Coalition for Addressing Health Disparities in Older Puerto Ricans.

    Science.gov (United States)

    Orellano-Colón, Elsa M; González-Laboy, Yolanda; De Jesús-Rosario, Amarelis

    2017-06-01

    The objective of this project was to develop a community-academic coalition partnership to conduct community-based participatory research (CBPR) to address health disparities in older adults with chronic conditions living in the Quebrada Arriba community. We used the 'Developing and Sustaining CPPR Partnerships: A Skill-Building Curriculum', to create the Quebrada Arriba Community-Academic Partnership (QACAP). We assessed the meetings effectiveness and the CBPR experiences of the coalition members in the community-academic partnership. The stepwise process resulted in: the development of The Coalition for the Health and Wellbeing of Older People of Quebrada Arriba; the partnership's mission and vision; the operating procedures; the formulation of the research question, and; the action plan for obtaining funding resources. The mean levels of satisfaction for each of the items of the Meeting Effectiveness Evaluation tool were 100%. The mean agreement rating scores on variables related to having a positive experience with the coalition, members' representativeness of community interest, respectful contacts between members, the coalition's vision and mission, the participation of the members in establishing the prioritized community problem, and sharing of resources between the members was 100%. The steps used to build the QACAP provided an effective structure to create the coalition and captured the results of coalition activities. Partners' time to build trust and developing a sufficient understanding of local issues, high interest of the community members, flexibility of the partners, capitalization on the partners' strengths, and the shared decision building process were key contributors of this coalition's success.

  12. Estabilidad y rupturas dinámica en el Holoceno de la costa surperuana: el valle de La Quebrada de los burros (departamento de Tacna

    Directory of Open Access Journals (Sweden)

    1999-01-01

    Full Text Available STABILITÉ ET RUPTURES DYNAMIQUES DE L’HOLOCÈNE DE LA CÔTE SUD-PÉRUVIENNE : LA VALLÉE DE LA QUEBRADA DE LOS BURROS (DÉPARTEMENT DE TACNA. L’examen et la datation des dépôts sédimentaires conservés le long de la Quebrada de los Burros (département de Tacna, Pérou, précisent la connaissance des variations climatiques et dynamiques de la période 8500-3200 BP. Deux épisodes à laves torrentielles, violents et certainement brefs, encadrent une longue période nettement plus calme durant laquelle se sont déposés des sédiments fins, parfois organiques, contemporains de la présence d’installations humaines. El estudio y la datación de los sedimentos depositados a lo largo de la Quebrada de los Burros (departamento de Tacna, Perú, permiten un buen conocimiento de las variaciones climáticas y dinámicas del periodo 8500-3200 BP. Dos episodios con lavas torrenciales, violentos y seguramente breves, encajan en un largo periodo nítidamente más tranquilo, donde se depositan sedimentos finos, a veces orgánicos, contemporáneos de la presencia de instalaciones humanas. HOLOCENIC STABILITY AND BREAKS IN THE SOUTHERN PERUVIAN COAST: THE QUEBRADA DE LOS BURROS VALLEY (DEPARTMENT OF TACNA. Radiocarbon measurements of organic sedimentary deposits from the Quebrada de los Burros (Department of Tacna, Peru permit the reconstruction of climate dynamics during the mid-Holocene (3200-8500 years BP.Two short debris flow events marks the beginning and the end of period of fine grain sedimentation processes. This period is contemporaneous with the presence of human settlements in the Quebrada.

  13. Analysis of the dynamic of underground water in Agua Verde, Quebrada de Taltal, region of Antofagasta, Chile

    International Nuclear Information System (INIS)

    Rojas, Luis; Lillo, Adrian; Salazar, Carlos; Aguirre, Evelyn

    2003-01-01

    The extreme aridity and geological situation in northern. Chile requires an exhaustive investigation on water resources for supporting rational usage. The Direccion General de Aguas and Comision Chilena de Energia Nuclear have performed studies in arid zones in northern Chile using isotopic and hydrochemical tools. In Quebrada de Taltal's basin, located in one of the must arid arid zones of Chile (Segunda Region de Antofagasta), was studies groundwater dynamics and recharge process from a geochemical approach in terms of water quality, temperature and isotopic composition ( 2 H, 18 O, 3 H, 14 C). The recharge generated above 3000 m a.s.t has a slow dynamics and involve little flow (author)

  14. Los Humedales de la Quebrada Estero en San Ramón, Costa Rica: importancia y estado actual.

    OpenAIRE

    Rodríguez-Arias, Cindy Elena; Silva Benavides, Ana Margarita

    2017-01-01

    Los humedales de la microcuenca alta de la Quebrada Estero, en San Ramón, Costa Rica, son considerados una prioridad de conservación por su representatividad y ubicación que los hace únicos en su tipo. Por eso se planteó el objetivo de conocer su importancia y estado actual para que esta información sirva de base para su recuperación y conservación. Se llevó a cabo la identificación de los servicios ecosistémicos y de las amenazas e impactos que tienen las actividades humanas en ellos mediant...

  15. Índices de calidad del agua en la microcuenca de la quebrada Victoria, Guanacaste, Costa Rica (2007-2008)

    OpenAIRE

    Zhen-Wu, Bi Yun

    2010-01-01

    Se evaluó, durante el año hidrológico 2007-2008, la calidad del agua de la quebrada Victoria, Costa Rica, mediante la aplicación de los índices de calidad del agua del Reglamento costarricense para la evaluación y clasificación de la calidad de cuerpos de agua superficiales (IHCA-CR) y el de la Fundación Nacional de Sanidad de los Estados Unidos (ICA-U.S.NSF), para establecer una línea base para los programas de seguimiento de su calidad y de los efectos del desarrollo geotérmico. La red de m...

  16. Mass movements in the Rio Grande Valley (Quebrada de Humahuaca, Northwestern Argentina): a methodological approach to reduce the risk

    Science.gov (United States)

    Marcato, G.; Pasuto, A.; Rivelli, F. R.

    2009-10-01

    Slope processes such as slides and debris flows, are among the main events that induce effects on the Rio Grande sediment transport capacity. The slides mainly affect the slope of the Rio Grande river basin while debris and mud flows phenomena take place in the tributary valleys. In the past decades several mass movements occurred causing victims and great damages to roads and villages and therefore hazard assessment and risk mitigation is of paramount importance for a correct development of the area. This is also an urgent need since the Quebrada de Humahuaca was recently included in the UNESCO World Cultural Heritage. The growing tourism business may lead to an uncontrolled urbanization of the valley with the consequent enlargement of threatened areas. In this framework mitigation measures have to take into account not only technical aspects related to the physical behaviour of the moving masses but also environmental and sociological factors that could influence the effectiveness of the countermeasures. Mitigation of landslide effects is indeed rather complex because of the large extension of the territory and the particular geological and geomorphological setting. Moreover the necessity to maintain the natural condition of the area as prescribed by UNESCO, make this task even more difficult. Nowadays no in-depth study of the entire area exists, therefore an integrated and multidisciplinary investigation plan is going to be set up including geological and geomorphological investigations as well as archaeological and historical surveys. The better understanding of geomorphological evolution processes of the Quebrada de Humahuaca will bridge the gap between the necessity of preservation and the request of safety keeping of the recommendation by UNESCO.

  17. Mass movements in the Rio Grande Valley (Quebrada de Humahuaca, Northwestern Argentina: a methodological approach to reduce the risk

    Directory of Open Access Journals (Sweden)

    G. Marcato

    2009-10-01

    Full Text Available Slope processes such as slides and debris flows, are among the main events that induce effects on the Rio Grande sediment transport capacity. The slides mainly affect the slope of the Rio Grande river basin while debris and mud flows phenomena take place in the tributary valleys. In the past decades several mass movements occurred causing victims and great damages to roads and villages and therefore hazard assessment and risk mitigation is of paramount importance for a correct development of the area. This is also an urgent need since the Quebrada de Humahuaca was recently included in the UNESCO World Cultural Heritage. The growing tourism business may lead to an uncontrolled urbanization of the valley with the consequent enlargement of threatened areas.

    In this framework mitigation measures have to take into account not only technical aspects related to the physical behaviour of the moving masses but also environmental and sociological factors that could influence the effectiveness of the countermeasures.

    Mitigation of landslide effects is indeed rather complex because of the large extension of the territory and the particular geological and geomorphological setting. Moreover the necessity to maintain the natural condition of the area as prescribed by UNESCO, make this task even more difficult.

    Nowadays no in-depth study of the entire area exists, therefore an integrated and multidisciplinary investigation plan is going to be set up including geological and geomorphological investigations as well as archaeological and historical surveys. The better understanding of geomorphological evolution processes of the Quebrada de Humahuaca will bridge the gap between the necessity of preservation and the request of safety keeping of the recommendation by UNESCO.

  18. Debris flood hazard documentation and mitigation on the Tilcara alluvial fan (Quebrada de Humahuaca, Jujuy province, North-West Argentina

    Directory of Open Access Journals (Sweden)

    G. Marcato

    2012-06-01

    Full Text Available For some decades, mass wasting processes such as landslides and debris floods have been threatening villages and transportation routes in the Rio Grande Valley, named Quebrada de Humauhuaca. One of the most significant examples is the urban area of Tilcara, built on a large alluvial fan. In recent years, debris flood phenomena have been triggered in the tributary valley of the Huasamayo Stream and reached the alluvial fan on a decadal basis.

    In view of proper development of the area, hazard and risk assessment together with risk mitigation strategies are of paramount importance. The need is urgent also because the Quebrada de Humahuaca was recently included in the UNESCO World Cultural Heritage. Therefore, the growing tourism industry may lead to uncontrolled exploitation and urbanization of the valley, with a consequent increase of the vulnerability of the elements exposed to risk. In this context, structural and non structural mitigation measures not only have to be based on the understanding of natural processes, but also have to consider environmental and sociological factors that could hinder the effectiveness of the countermeasure works.

    The hydrogeological processes are described with reference to present-day hazard and risk conditions. Considering the socio-economic context, some possible interventions are outlined, which encompass budget constraints and local practices. One viable solution would be to build a protecting dam upstream of the fan apex and an artificial channel, in order to divert the floodwaters in a gully that would then convey water and sediments into the Rio Grande, some kilometers downstream of Tilcara. The proposed remedial measures should employ easily available and relatively cheap technologies and local workers, incorporating low environmental and visual impacts issues, in order to ensure both the future conservation of the site and its safe exploitation for inhabitants and tourists.

  19. Debris flood hazard documentation and mitigation on the Tilcara alluvial fan (Quebrada de Humahuaca, Jujuy province, North-West Argentina)

    Science.gov (United States)

    Marcato, G.; Bossi, G.; Rivelli, F.; Borgatti, L.

    2012-06-01

    For some decades, mass wasting processes such as landslides and debris floods have been threatening villages and transportation routes in the Rio Grande Valley, named Quebrada de Humauhuaca. One of the most significant examples is the urban area of Tilcara, built on a large alluvial fan. In recent years, debris flood phenomena have been triggered in the tributary valley of the Huasamayo Stream and reached the alluvial fan on a decadal basis. In view of proper development of the area, hazard and risk assessment together with risk mitigation strategies are of paramount importance. The need is urgent also because the Quebrada de Humahuaca was recently included in the UNESCO World Cultural Heritage. Therefore, the growing tourism industry may lead to uncontrolled exploitation and urbanization of the valley, with a consequent increase of the vulnerability of the elements exposed to risk. In this context, structural and non structural mitigation measures not only have to be based on the understanding of natural processes, but also have to consider environmental and sociological factors that could hinder the effectiveness of the countermeasure works. The hydrogeological processes are described with reference to present-day hazard and risk conditions. Considering the socio-economic context, some possible interventions are outlined, which encompass budget constraints and local practices. One viable solution would be to build a protecting dam upstream of the fan apex and an artificial channel, in order to divert the floodwaters in a gully that would then convey water and sediments into the Rio Grande, some kilometers downstream of Tilcara. The proposed remedial measures should employ easily available and relatively cheap technologies and local workers, incorporating low environmental and visual impacts issues, in order to ensure both the future conservation of the site and its safe exploitation for inhabitants and tourists.

  20. Gestion de l'environnement urbain et risques 'naturels'. La problématique des Quebradas à Quito (Equateur

    Directory of Open Access Journals (Sweden)

    1996-01-01

    Full Text Available Les nombreuses quebradas, ravins à écoulement sporadique qui traversent le site de Quito, ont été systématiquement remblayées lors de l’urbanisation, pour servir notamment de zones de décharge plus ou moins contrôlée pour les déchets solides. À partir d’une cartographie diachronique, l’historique de ce remblaiement du réseau hydrographique est décrit, et les risques de nature morphoclimatique induits par ces profondes transformations, étudiés par ailleurs, sont brièvement évoqués. Ces zones spécifiques d’un site urbain de montagne relèvent d’un statut juridique de protection propre au réseau hydrographique en ville, lequel est profondément modifié dans la pratique après remblaiement, voire simplement oublié. Tout se passe comme si le remblaiement et l’urbanisation du réseau hydrographique faisaient l’objet d’un large consensus social, pour gagner de l’espace, donner une solution intra-urbaine à l’évacuation des déchets, et éradiquer des zones socialement incontrôlées. Les représentations sociales qui induisent une politique non explicite de gestion du site, sont analysées et discutées, au moment où les gestionnaires de la ville s’interrogent quant au bien-fondé de la poursuite du processus, alors que ce dernier se poursuit activement pour cacher la forte pollution du rio Machangara, principal émissaire du bassin. MANEJO DEL MEDIO AMBIENTE Y RIESGOS “NATURALES”. LA PROBLEMÁTICA DE LAS QUEBRADAS EN QUITO (ECUADOR. Las numerosas quebradas que atraviesan la ciudad de Quito fueron constantemente rellenadas durante el proceso de urbanización, sirviendo de basurero controlado o no. Se describe la historia del relleno de la red hidrográfica mediante su cartografía en el tiempo, y los riesgos de tipo morfoclimático producidos por esas transformaciones, que fueron investigados anteriormente, son resumidos. Las zonas de quebradas, específicas de un sitio urbano montañoso, tienen un estatuto jur

  1. ESTUDIOS DE ISÓTOPOS ESTABLES EN HUERTAS FAMILIARES ACTUALES DE LA QUEBRADA DE HUMAHUACA (JUJUY, ARGENTINA. SU POTENCIAL APORTE A LOS ESTUDIOS PALEODIETARIOS DEL NOROESTE ARGENTINO / Stable isotope studies on current home gardens of the Quebrada de ...

    Directory of Open Access Journals (Sweden)

    Violeta A. Killian Galván

    2015-12-01

    Full Text Available Presentamos una propuesta metodológica para la generación de marcos de referencia en los estudios paleodietarios, mediante el análisis de la composición isotópica del carbono y el nitrógeno (?13C y ?15N en arqueología. En particular, nos centraremos en cómo influyen algunas prácticas de cultivo en los valores isotópicos de las plantas procedentes de huertas familiares (siendo las especies escogidas Zea mays, Solanum tuberosum, Oxalis tuberosa, Ullucus tuberosus, Chenopodium quinoa y Opuntia ficus-indica, esta última como especie silvestre del área. La metodología propuesta consiste en: el relevamiento de información entre productores locales, la caracterización del suelo en cuanto a sus propiedades químicas (pH, conductividad eléctrica, carbono orgánico y nitratos y la medición isotópica de los vegetales muestreados. A partir de los resultados obtenidos, podemos afirmar que al menos en entornos semiáridos, como es el caso de Quebrada de Humahuaca, la disponibilidad de nutrientes en el suelo repercute en los valores ?15N de Zea mays. Si bien no hay una relación lineal entre las variables propuestas y los resultados isotópicos obtenidos, se registró un rango más amplio de valores cuando la calidad del suelo fue menor. AbstractWe present a methodological proposal for the construction of a frame of reference in paleodietary research through the analysis of Carbon and Nitrogen stable isotopes (?13C y ?15N in archaeology. In particular, we focus on the effect of certain harvest practices in the isotopic values of plants from family farms (the species chosen being Zea mays, Solanum tuberosum, Amaranthus caudatus, Chenopodium quinoa and Opuntia ficus-indica, this last as a wild plant from the area. The methodology consist in: collection of information among local producers, soil characterization in terms of their chemical properties (Ph, electrical conductivity, organic carbon and nitrate and analysis of isotopic values from

  2. Integrated U-Pb zircon and palynological/palaeofloristic age determinations of a Bashkirian palaeofjord fill, Quebrada Grande (Western Argentina)

    Science.gov (United States)

    Valdez Buso, Victoria; di Pasquo, Mercedes; Milana, Juan Pablo; Kneller, Benjamin; Fallgatter, Claus; Junior, Farid Chemale; Gomes Paim, Paulo Sérgio

    2017-01-01

    This work presents a new age framework for the main Bashkirian glacio-eustatic transgression in Argentina, including the first absolute age for the Jejenes Formation, San Juan Province, based on radiometric dating of a crystal-rich tuff, supported by palynological and palaeofloristic studies, and presented within a revised palaeogeographic setting. The Jejenes Formation represents the glacial to postglacial fill of the Quebrada Grande palaeofjord carved in the Eastern Precordillera. The succession has been subdivided into five stages, the youngest of which suggests a previously unrecognised glacial event for this locality. Six productive levels for palynology were found within proglacial strata, and in the base and top of the succeeding interglacial stage. Palynoassemblages are characterized by poorly preserved trilete spores and monosaccate pollen grains along with a large amount of terrestrial phytoclasts. Main species indicating the Raistrickia densa-Convolutispora muriornata SubZone (DMa SZ) are Vallatisporites ciliaris, Cristatisporites rollerii, C. stellatus, C. chacoparanensis, C. inconstans and monosaccates such as Circumplicatipollis plicatus. This DMa SZ is estimated as Serpukhovian/Bashkirian and characterizes the glacial-related Guandacol Formation and equivalents units of the western Paganzo Basin. A tuffaceous level in the proglacial unit, bearing platyspermic seeds, plant remains and palynomorphs, yielded first-cycle volcanic zircons that were analysed by SHRIMP. An absolute age of 321.3 ± 5.3 Ma confirms a Bashkirian age for the main postglacial transgression in the Paganzo Basin, and offers a novel calibration for the palynoassemblages of DMa SZ that occurs elsewhere in Western Argentina.

  3. CARACTERIZACIÓN Y PROCEDENCIA DE MATERIAS PRIMAS PARA LA PRODUCCIÓN DE ALFARERÍA PREHISPÁNICA EN LA QUEBRADA DE HUMAHUACA (PROVINCIA DE JUJUY, REPÚBLICA ARGENTINA: FRX, ICP Y PETROGRAFÍA DE PASTAS (Characterization and Provenance of Raw Materials for the Production of Prehispanic Pottery in Quebrada de Humahuaca (Jujuy Province, Argentina: XRF, ICP and Ceramic Petrography

    Directory of Open Access Journals (Sweden)

    Nicolás E. Larcher

    2016-03-01

    Full Text Available Se presenta un avance en la investigación arqueométrica de la alfarería prehispánica de la Quebrada de Humahuaca, territorio ubicado en el extremo noroeste de Argentina. Se analizaron 72 muestras de cerámicas y arcillas por FRX e ICP en tres laboratorios distintos. La integración de los datos y su procesamiento estadístico permitió identificar 4 grupos con características químicas definidas. La petrografía de pastas aportó información extra que ayudó a corroborar la congruencia de los agrupamientos obtenidos. Los resultados permitieron relacionar arcillas con cerámicas, diferenciar químicamente las arcillas y cerámicas de dos sectores de la Quebrada de Humahuaca estudiados e identificar posibles evidencias de interacción. ENGLISH: This article presents a new archaeometric investigation of prehispanic pottery from Quebrada de Humahuaca, a valley in the northwesternmost region of Argentina. We assayed 72 samples from pottery and clays using X-RF and ICP in three different laboratories. Data integration and statistical processing allowed us to identify 4 groups with defined chemical signatures. Ceramic petrology provided additional information that helped us to corroborate the coherence of the clustering. The results enabled us to correlate clays with pottery, to establish chemical differences between the clays and pottery of two areas of Quebrada de Humahuaca that have been investigated archaeologically, and to identify possible evidence of social interaction.

  4. Geological setting and paleomagnetism of the Eocene red beds of Laguna Brava Formation (Quebrada Santo Domingo, northwestern Argentina)

    Science.gov (United States)

    Vizán, H.; Geuna, S.; Melchor, R.; Bellosi, E. S.; Lagorio, S. L.; Vásquez, C.; Japas, M. S.; Ré, G.; Do Campo, M.

    2013-01-01

    The red bed succession cropping out in the Quebrada Santo Domingo in northwestern Argentina had been for long considered as Upper Triassic-Lower Jurassic in age based on weak radiometric and paleontological evidence. Preliminary paleomagnetic data confirmed the age and opened questions about the nature of fossil footprints with avian features discovered in the section. Recently the stratigraphic scheme was reviewed with the identification of previously unrecognized discontinuities, and a radiometric dating obtained in a tuff, indicated an Eocene age for the Laguna Brava Formation and the fossil bird footprints, much younger than the previously assigned. We present a detailed paleomagnetic study interpreted within a regional tectonic and stratigraphic framework, looking for an explanation for the misinterpretation of the preliminary paleomagnetic data. The characteristic remanent magnetizations pass a tilt test and a reversal test. The main magnetic carrier is interpreted to be low Ti titanomagnetites and to a lesser extent hematite. The characteristic remanent magnetization would be essentially detrital. The obtained paleomagnetic pole (PP) for the Laguna Brava Formation has the following geographic coordinates and statistical parameters: N = 29, Lon. = 184.5° E, Lat. = 75.0° S, A95 = 5.6° and K = 23.7. When this PP is compared with another one with similar age obtained in an undeformed area, a declination anomaly is recognized. This anomaly can be interpreted as Laguna Brava Formation belonging to a structural block that rotated about 16° clockwise along a vertical axis after about 34 Ma. This block rotation is consistent with the regional tectonic framework, and would have caused the fortuitous coincidence of the PP with Early Jurassic poles. According to the interpreted magnetostratigraphic correlation, the Laguna Brava Formation would have been deposited during the Late Eocene with a mean sedimentation rate of about 1.4 cm per thousand years, probably in

  5. Archosauriform remains from the Late Triassic of San Luis province, Argentina, Quebrada del Barro Formation, Marayes-El Carrizal Basin

    Science.gov (United States)

    Gianechini, Federico A.; Codorniú, Laura; Arcucci, Andrea B.; Castillo Elías, Gabriela; Rivarola, David

    2016-03-01

    Here we present archosauriform remains from 'Abra de los Colorados', a fossiliferous locality at Sierra de Guayaguas, NW San Luis Province. Two fossiliferous levels were identified in outcrops of the Quebrada del Barro Formation (Norian), which represent the southernmost outcrops of the Marayes-El Carrizal Basin. These levels are composed by massive muddy lithofacies, interpreted as floodplain deposits. The specimens consist of one incomplete maxilla (MIC-V718), one caudal vertebra (MIC-V719), one metatarsal (MIC-V720) and one indeterminate appendicular bone (MIC-V721). The materials can be assigned to Archosauriformes but the fragmentary nature and lack of unambiguous synapomorphies preclude a more precise taxomic assignment. The maxilla is remarkably large and robust and represents the posterior process. It preserved one partially erupted tooth with ziphodont morphology. This bone shows some anatomical traits and size match with 'rauisuchians' and theropods. MIC-V719 corresponds to a proximal caudal vertebra. It has a high centrum, a ventral longitudinal furrow, expanded articular processes for the chevrons, a posteriorly displaced diapophysis located below the level of the prezygapophyses, and short prezygapophyses. This vertebra would be from an indeterminate archosauriform. MIC-V720 presents a cylindrical diaphysis, with a well-developed distal trochlea, which present resemblances with metatarsals of theropods, pseudosuchians, and silesaurids, although the size matches better with theropods. MIC-V721 has a slender diaphysis and a convex triangular articular surface, and corresponds to an indeterminate archosauriform. Despite being fragmentary, these materials indicate the presence of a diverse archosauriforms association from Late Triassic beds of San Luis. Thus, they add to the faunal assemblage recently reported from this basin at San Juan Province, which is much rich and diverse than the coeval paleofauna well known from Los Colorados Formation in the

  6. CARACTERIZACIÓN DE LA COMUNIDAD DE MACROINVERTEBRADOS DE LA QUEBRADA PALOBLANCO DE LA CUENCA DEL RÍO OTÚN (RISARALDA, COLOMBIA)

    OpenAIRE

    ELEONORA BERNAL; DUBERNEY GARCÍA; MIGUEL A. NOVOA; ATTICUS PINZÓN

    2006-01-01

    Se realizó un estudio de las comunidades de macroinvertebrados presentes en la quebrada Paloblanco, ubicada en la cuenca del río Otún (Risaralda, Colombia). Los puntos de muestreo seleccionados corresponden a la cabecera y la zona cercana a la desembocadura en el río Otún, ambos con características geomorfológicas de corrientes de primer orden. En cada punto se colectaron los macroinvertebrados de las unidades funcionales hojarasca, epiliton, musgo y grava, junto con una muestra de deriva y f...

  7. Caracterización de la comunidad de macroinvertebrados de la Quebrada Paloblanco de la Cuenca del Río Otún (Risaralda, Colombia)

    OpenAIRE

    Eleonora Bernal Pinilla; Duberney García García; Miguel Adriano Novoa Bravo; Atticus Pinzón Rodríguez

    2006-01-01

    Se realizó un estudio de las comunidades de macroinvertebrados presentes en la quebrada Paloblanco, ubicada en la cuenca del río Otún (Risaralda, Colombia). Los puntos de muestreo seleccionados corresponden a la cabecera y la zona cercana a la desembocadura en el río Otún, ambos con características geomorfológicas de corrientes de primer orden. En cada punto se colectaron los macroinvertebrados de las unidades funcionales hojarasca, epiliton, musgo y grava, junto con una muestra de deriva y f...

  8. Volatility Discovery

    DEFF Research Database (Denmark)

    Dias, Gustavo Fruet; Scherrer, Cristina; Papailias, Fotis

    The price discovery literature investigates how homogenous securities traded on different markets incorporate information into prices. We take this literature one step further and investigate how these markets contribute to stochastic volatility (volatility discovery). We formally show...... that the realized measures from homogenous securities share a fractional stochastic trend, which is a combination of the price and volatility discovery measures. Furthermore, we show that volatility discovery is associated with the way that market participants process information arrival (market sensitivity......). Finally, we compute volatility discovery for 30 actively traded stocks in the U.S. and report that Nyse and Arca dominate Nasdaq....

  9. En sus huaycos y quebradas: formas materiales de la resistencia en las tierras de malfín Material forms of resistance in the lands of malfín: huaycos and quebradas

    Directory of Open Access Journals (Sweden)

    Laura Quiroga

    2010-12-01

    Full Text Available Las representaciones coloniales en torno a los espacios geográficos expresadas en cartografías o textos traducen un campo de disputa por el control de espacios, recursos y redes sociales. Para el dominio colonial las quebradas más altas del ambiente serrano, ubicadas en la jurisdicción de Londres de la gobernación del Tucumán, representaban espacios de refugio y resistencia de la población nativa. Pero esta estrategia no era producto de una conducta propia de una situación de peligro en la guerra sino un recurso previsto y planeado para el que se reconoce una profundidad temporal enlazada con prácticas de subsistencia y reproducción propias del tardío prehispánico, y resignificadas en un contexto colonial de guerra y transformación. Convertir el término "huayco" en un problema de investigación supone transformar una categoría geográfica, característica de un relieve serrano, en la descripción e interpretación de una práctica que construye resistencias como condiciones para la reproducción social.Colonial representations of geographic spaces drawn either on books or texts point out a dispute camp over spaces, resources, and social networks. Thus the higher mountain ravines around Londres -Gobernación del Tucumán- became from an indigenous perspective, a refuge and a resistance space to challenge colonial domain. These strategies were not driven by the threat of war but predictable and planned resources attached to the Indian's subsistence and reproductive tactics, carried out from the late prehispanic period to the colonial context of transformation and war. Turning the term huayco into a research problem implies to transform a geographic category, a feature of a mountainous landscape, in a concept suitable to describe and interpret a social practice that builds resistance as a condition of social reproduction.

  10. Evaluación del contenido de mercurio en suelos y lechos de quebradas en la zona minera de Miraflores, Quinchía, Colombia

    Directory of Open Access Journals (Sweden)

    Juan Carlos Camargo García

    2015-04-01

    Full Text Available En la vereda Miraflores, municipio de Quinchía, Risaralda, donde se ha realizado minería aurífera de forma artesanal durante más de tres décadas, se evaluó el contenido de mercurio (Hg en suelos y lechos de quebradas. Para el efecto se realizó un muestreo sistemático considerando montajes de minería activa, inactiva y áreas sin intervenir. Igualmente se hicieron observaciones en las partes altas, medias y bajas en lechos de quebradas naturales y drenajes formados artificialmente por el desvío de cauces. Los promedios de los valores de Hg (7.1 mg/kg fueron más altos en aquellos lugares aledaños a los montajes y cuando la precipitación aumentó. Aunque en Colombia existe poca información y normatividad relacionada con la contaminación de suelos, los valores de Hg encontrados superan los niveles permisibles establecidos por países europeos. La degradación de suelos se presenta asociada con la contaminación y los residuos de roca dispuestos, hasta el punto de formar zonas eriales totalmente degradadas.

  11. Comunidades herpetológicas de la reserva de La Quebrada, Río Ceballos, Córdoba (Argentina

    Directory of Open Access Journals (Sweden)

    Gavier, Gregorio

    2003-11-01

    Full Text Available La presente investigación se desarrolló en un ambiente característico de las sierras Chicas de Córdoba, la Reserva La Quebrada. El objetivo del estudio fue describir la composición y diversidad de la comunidad herpetofaunística, sus cambios estacionales, y estudiar si existen comunidades diferentes asociadas a los ecosistemas de pastizal, bosque y borde de arroyo. También se analizó su relación con las variables ambientales climáticas. Se instalaron de una a tres líneas de muestreo por ambiente, cada una con 15 trampas de caída separadas por una distancia de 10 m, que se revisaron mensualmente entre febrero de 1991 y mayo de 1994. Se capturaron 147 especímenes distribuidos entre 21 especies: 8 anfibios (n= 114, 8 ofidios (n= 9 y 5 saurios (n= 24. Odontophrynus occidentalis e Hyla pulchella cordobae sumaron alrededor del 60% de la abundancia total. H. p. cordobae fue la especie de distribución más amplia. Las especies más abundantes en los diferentes ambientes fueron Odontophrynus americanus y Leptodactylus gracilis en pastizal, O. occidentalis y Mabuya dorsivittata en bosque, O. occidentalis e H. p. cordobae en bordes de arroyo. Los ambientes estudiados no mostraron diferencias en cuanto a la riqueza o abundancia de individuos, pero sí en relación a la composición de las comunidades y los cambios estacionales en abundancias. La diversidad fue mayor en el pastizal (H'=1,93 con respecto al bosque (H'=1,41 y al borde de arroyo (H'=1,19. Abundancia, riqueza y diversidad para la Reserva en su conjunto correlacionaron en forma directa con temperatura y precipitación. Se comprobó la existencia de dos comunidades diferentes, una relacionada al ambiente de pastizal y otra a la unidad formada por el bosque y el borde de arroyo. Las altas tasas de deforestación registradas en el área podrían modificar las relaciones de abundancias entre especies y los patrones de biodiversidad en el área.La presente investigación se desarrolló en

  12. Gorgona, Baudó y Darién (Chocó Biogeográfico, Colombia: ecorregiones modelo para los estudios ecológicos de comunidades de quebradas costeras

    Directory of Open Access Journals (Sweden)

    Juan F. Blanco

    2014-02-01

    Full Text Available A pesar de la escasez de estudios sobre la geología, hidrología y biota de las quebradas costeras ubicadas en el Chocó Biogeográfico, se hipotetiza que éstas se ajustan a la tipología observada en las islas oceánicas volcánicas del Caribe y el Pacífico, las cuales no cumplen con las predicciones del Concepto del Río Continuo. Estas quebradas son cortas (<10¹km y muy pendientes debido a su origen tectónico, y presentan lechos dominados por bloques y cantos rodados. El régimen de caudal es torrencial en la vertiente Pacífico, pero estacionalmente seco en la vertiente Caribe. Los doseles cerrados aportan grandes cantidades de hojarasca a las quebradas que desembocan al mar con bajo orden. Las especies diádromas, con afinidades centroamericanas y antillanas, dominan los ensamblajes y posiblemente cumplen papeles ecológicos equivalentes a los establecidos en otras regiones. Particularmente, las quebradas costeras de esta provincia presentan varias especies de peces dulceacuícolas primarios, algunas endémicas, y carecen de gasterópodos. Los procesos geomorfológicos e hidrológicos de las cabeceras influyen sobre la dinámica ecosistémica de estas quebradas. Se proponen cinco hipótesis sobre la estructura y composición comunitaria. Se advierte que el PNNG es un modelo útil para la ecología lótica costera, pero que tiene particularidades.

  13. Beyond Discovery

    DEFF Research Database (Denmark)

    Korsgaard, Steffen; Sassmannshausen, Sean Patrick

    2017-01-01

    In this chapter we explore four alternatives to the dominant discovery view of entrepreneurship; the development view, the construction view, the evolutionary view, and the Neo-Austrian view. We outline the main critique points of the discovery presented in these four alternatives, as well...

  14. Chemical Discovery

    Science.gov (United States)

    Brown, Herbert C.

    1974-01-01

    The role of discovery in the advance of the science of chemistry and the factors that are currently operating to handicap that function are considered. Examples are drawn from the author's work with boranes. The thesis that exploratory research and discovery should be encouraged is stressed. (DT)

  15. Giant fossil tortoise and freshwater chelid turtle remains from the middle Miocene, Quebrada Honda, Bolivia: Evidence for lower paleoelevations for the southern Altiplano

    Science.gov (United States)

    Cadena, Edwin A.; Anaya, Federico; Croft, Darin A.

    2015-12-01

    We describe the first Miocene turtle remains from Bolivia, which were collected from the late middle Miocene (13.18-13.03 Ma) of Quebrada Honda, southern Bolivia. This material includes a large scapula-acromion and fragmentary shell elements conferred to the genus Chelonoidis (Testudinidae), and a left xiphiplastron from a pleurodire or side-necked turtle, conferred to Acanthochelys (Chelidae). The occurrence of a giant tortoise and a freshwater turtle suggests that the paleoelevation of the region when the fossils were deposited was lower than has been estimated by stable isotope proxies, with a maximum elevation probably less than 1000 m. At a greater elevation, cool temperatures would have been beyond the tolerable physiological limits for these turtles and other giant ectotherm reptiles.

  16. Influencia de la intervención antrópica en la ocurrencia de procesos de ladera. Microcuenca de la quebrada Ramos, Flanco Norandino venezolano

    OpenAIRE

    Katty Montiel Albornoz; Edith Gouveia Muñetón; Eloy Montes Galbán

    2007-01-01

    El objetivo de este trabajo es analizar la influencia de la intervención antrópica en la ocurrencia de procesos de ladera, en la microcuenca de la quebrada Ramos. Para ello se efectuó un análisis de las condiciones biofísicas a través del método heurístico (Van Westen, 2003) y se identificaron las variables espaciales de mayor incidencia en la dinámica local, mediante la teledetección, inspección de campo y la aplicación de un modelo bajo plataforma SIG, donde el núcleo esen...

  17. O setor hoteleiro na praia de Canoa Quebrada/CE: processo de expansão urbana e turística

    Directory of Open Access Journals (Sweden)

    Felipe de Souza Siqueira

    2017-06-01

    Full Text Available Este artigo discute a expansão da atividade turística na praia de Canoa Quebrada - Ceará, buscando entender suas implicações sobre o desenvolvimento do setor hoteleiro a partir das iniciativas pioneiras na década de 1970 até sua ampliação nos dias atuais. Seu foco principal é o setor hoteleiro, sua expansão e as transformações decorrentes do crescimento urbano e dos fluxos turísticos, abarcando as origens e as principais características desse setor, bem como a sua relação com a evolução da localidade. A operacionalização da pesquisa impôs a definição de um referencial teórico apropriado ao entendimento do processo de expansão da cidade e dos fluxos turísticos, de modo a propiciar a apreensão da totalidade dos elementos naturais e humanos definidores da realidade investigada. A análise dos processos locais relativos à expansão urbana e turística exigiu a sua articulação ao contexto regional e nacional, bem como a consulta à obras capazes de oferecer elementos acerca da realidade objeto da investigação, elucidando aspectos relacionados às origens e a evolução do setor hoteleiro, decorrentes de transformações sócio espaciais ocorridas em Canoa Quebrada.

  18. Higgs Discovery

    DEFF Research Database (Denmark)

    Sannino, Francesco

    2013-01-01

    has been challenged by the discovery of a not-so-heavy Higgs-like state. I will therefore review the recent discovery \\cite{Foadi:2012bb} that the standard model top-induced radiative corrections naturally reduce the intrinsic non-perturbative mass of the composite Higgs state towards the desired...... via first principle lattice simulations with encouraging results. The new findings show that the recent naive claims made about new strong dynamics at the electroweak scale being disfavoured by the discovery of a not-so-heavy composite Higgs are unwarranted. I will then introduce the more speculative......I discuss the impact of the discovery of a Higgs-like state on composite dynamics starting by critically examining the reasons in favour of either an elementary or composite nature of this state. Accepting the standard model interpretation I re-address the standard model vacuum stability within...

  19. Entre desierto y quebrada. Primeros resultados de las excavaciones realizadas en el abrigo de Tomayoc (Puna de Jujuy, Argentina

    Directory of Open Access Journals (Sweden)

    1997-01-01

    Full Text Available ENTRE DÉSERT ET QUEBRADA. PREMIERS RESULTATS DES FOUILLES REALISEES DANS L'ABRI DE TOMAYOC (PUNA DE JUJUY, ARGENTINE. Dans cet article sont exposés les principaux résultats des fouilles réalisées de 1987 à 1990 dans l’abri de Tomayoc (Sierra de Aguilar, Jujuy, Argentine. La chronologie de l’occupation, qui s’étend de 4250±50 BP à 550±50 BP, est présentée et discutée, de même que la stratigraphie. En dépit des effets prononcés de l’érosion ayant fortement affecté les dépôts archéologiques, les vestiges plus ou moins importants de huit sols d’occupation ont été mis au jour par la méthode du “décapage”. Ces sols résiduels, de superficie variable, ont pu être regroupés en quatre phases d’occupation, respectivement situées dans les périodes Archaïque (phases I et II “Temprano” (Phase III et “Tardio” (Phase IV, et définies à partir de critères chronologiques, stratigraphiques et typologiques. L’analyse paléoethnologique de chacun des sols d’occupation mis au jour a été réalisée. Parmi les résultats les plus importants, on note la présence d’un camélidé domestiqué (l’alpaca dès l’Archaïque (Phase II : 3480±40 - 3250±60 BP et, durant le “Temprano” (Phase III, la présence de céramique associée à une date de 2950±50 BP. En este artículo están expuestos los principales resultados de las excavaciones realizadas entre 1987 y 1990 en el abrigo de Tomayoc (Sierra de Aguilar, Jujuy, Argentina. La cronología de la ocupación, que va desde 4250±50 BP hasta 550±50 BP, es presentada y discutida, así como la estratigrafía. A pesar de los efectos pronunciados de la erosión que afectaron fuertemente los depósitos arqueológicos, los vestigios de ocho pisos de ocupación fueron evidenciados por el método del decapage. Estos pisos, de superficie variable, han sido reagrupados en cuatro fases de ocupación ubicadas respectivamente en el Período Arcaico (Fase I y II, el Período

  20. Pescadores-recolectores arcaicos del extremo sur peruano. Excavaciones en La Quebrada de los burros (Tacna, Perú. Primeros resultados 1995-1997

    Directory of Open Access Journals (Sweden)

    1999-01-01

    Full Text Available PÊCHEURS-COLLECTEURS ARCHAÏQUES DE L’EXTRÊME SUD PÉRUVIEN. LES FOUILLES DE LA QUEBRADA DE LOS BURROS (TACNA, PEROU. PREMIERS RESULTATS, 1995-1997. Au début de l´Archaïque, des groupes humains vivant des ressources marines et, en moindre mesure, de chasse terrestre, s’installent régulièrement sur la côte sud du Pérou. Dans la Quebrada de los Burros, les datations 14C situent ces occupations entre 9800 et 3200 BP, durant une période climatique calme et relativement humide la formation, dans la vallée, entre 120 et 200 m d’altitude, de lagunes d’eau douce ou de marécages constitue alors un facteur très favorable à une implantation humaine (voir Usselmann et al., ce volume. Les niveaux d’occupation exploités sur de larges surfaces ont livré des foyers, un abondant matériel lithique taillé, des accumulations de coquilles (Concholepas concholepas, Mesodesma donacium, Fissurella sp., Choromytilus chorus etc. et de nombreux restes de poissons très diversifiés, impliquant diverses techniques halieutiques. Sont également attestés quelques restes de mammifères terrestres et d’oiseaux. Diverses analyses en cours sur les coquilles détermineront s’il s’agissait d’installations saisonnières ou permanentes. Al inicio del Arcaico, grupos humanos que viven de los recursos del medio marítimo y, en escala menor, de la caza terrestre (camélidos, aves, están instalados en la costa sur del Perú. En la Quebrada de los Burros, fechados 14C sitúan estas ocupaciones entre 9800 y 3200 BP, durante un período climático tranquilo y relativamente húmedo en el fondo del valle, entre 120 y 200 msnm, la formación de lagunas de agua dulce o de pantanos constituye entonces un elemento muy favorable para una implantación humana (véase Usselmann et al., este volumen. Los niveles de ocupación excavados en un área extensa contenían fogones, un abundante material lítico tallado, acumulaciones de conchas marinas (Concholepas concholepas

  1. Imágenes postconquista y etnogénesis en la Quebrada de Humahuaca, Jujuy, Argentina: Hipótesis de trabajo arqueológico

    Directory of Open Access Journals (Sweden)

    Mariel Alejandra López

    2006-12-01

    Full Text Available Actualmente, y desde el punto de vista arqueológico, es poco lo que se conoce sobre el momento de contacto entre españoles e indígenas en la Quebrada de Humahuaca. La excepción es la esporádica mención de elementos de la cultura material europea, o sus representaciones rupestres, hallados fundamentalmente en sitios prehispánicos. A partir de investigaciones contemporáneas y estudios basados en material de colecciones y/o excavaciones pertenecientes al período que va desde los primeros contactos hispano-indígenas a la implementación del sistema colonial en la región han surgido nuevas hipótesis e interpretaciones arqueológicas. Estas últimas junto con los aportes realizados por la Historia, la Etnohistoria y la Historia del Arte andinos brindan nuevos planteos sobre objetos identificados arqueológicamente como arte mobiliar y el posible significado de sus representaciones de acuerdo con los contextos de uso, o función, determinados por los registros arqueológicos y el estudio de la crónica de la época.Currently, and from the standpoint of Archaeology, very little is known about the contact situation between indigenous and Hispanic people in Quebrada de Humahuaca. However the occasional mention of some objects belonging to the European material culture or their rock art, found mainly in indigenous pre-Hispanic sites is an exception. Based on contemporary research and studies of collections and/or archaeological remains of the period embracing the first contact situations until the establishment of the colonial system in the region new hypothesis and archaeological interpretations appeared. These together with approaches coming from Andean History, Ethnohistory and Art History have opened new lines of research regarding objects identified as mobile art and the meaning of their representations according to specific contexts of use proposed by archaeological records and documentary sources.

  2. Declaraciones patrimoniales, turismo y conocimientos locales: Posibilidades de los estudios del folklore para el caso de las ferias en la quebrada de Humahuaca (Jujuy-Argentina Patrimony Statements, Tourism and Local Knowledge: Folklore Studies Posibilities in Quebrada de Humahuaca Fairs Case (Jujuy - Argentina

    Directory of Open Access Journals (Sweden)

    Liliana Bergesio

    2010-12-01

    Full Text Available La Quebrada de Humahuaca se encuentra en la porción central de la provincia de Jujuy (al noroeste de la República Argentina y su poblamiento ronda los 11.000 años de antigüedad. Esta región fue declarada en el año 2003 por la Organización de las Naciones Unidas para la Educación, la Ciencia y la Cultura (UNESCO como "Patrimonio Cultural y Natural de la Humanidad". A partir de esa fecha se incrementó el desarrollo de circuitos turísticos de aventura y culturales. Esta declaración le dio un nuevo impulso a la Quebrada de Humahuaca en el mercado nacional e internacional del turismo. Y el auge de este último en la zona generó que cada pueblo buscara sus propias alternativas para atraer visitantes. Entre las estrategias más comunes está la realización de ferias y fiestas que buscan destacar características locales particulares. En este trabajo proponemos analizar el caso de la localidad de Coctaca (Departamento de Humahuaca y un evento que allí se realiza, en el mes de febrero, el cual incluye la Feria "Los Sabores de la Historia", el "Encuentro de Mujeres Andinas" y la "Serenata a los Andenes de Cultivo". El objetivo del trabajo es plantear las posibilidades que aportan los estudios del folklore para articular en el análisis temas como lo local y global; lo cultural y económico; los productores con sus productos y el turismo con sus demandas y expectativas.Quebrada de Humahuaca is set in the central portion of the Jujuy Province (Northwest of Argentinian Republic and it has been inhabited approximately by 11.000 years. In 2003 this region was declared "Cultural and Natural Patrimony of Mandkind" by The United Nations Educational, Scientific and Cultural Organization (UNESCO. From that date the cultural and adventure tourism circuits development increased. This statement gave new impetus to Quebrada de Humahuaca in the national and international tourism market. And the rise of the latter in the area generated each little town to

  3. Distribución espacial de Ephemeroptera, Plecoptera, Trichoptera y Coleoptera (Insecta en una quebrada de primer orden, bosque montano, Junín, Perú

    Directory of Open Access Journals (Sweden)

    Janet Isabel Sajamí Reymundo

    2016-08-01

    Full Text Available El objetivo de éste estudio fue estudiar la composición y distribución espacial de cuatro órdenes de insectos acuáticos Ephemeroptera, Plecoptera, Trichoptera y Coleoptera (EPTC, en una quebrada de primer orden, Chanchamayo, Perú. Se realizaron colectas bimensuales desde marzo del 2013 a enero del 2014 en cuatro microhábitats lóticos: piedra, grava, musgo y hojas retenidas en la corriente. Fueron colectados un total de 7825 individuos agrupados en 51 géneros distribuidos en 27 familias de EPTC. El microhábitat de hoja retenida en los rápidos presentó la mayor abundancia, riqueza y diversidad de EPTC. Los géneros más representativos en términos de abundancia fueron Farrodes (10.35%, Phylloicus (10.01% y Heterelmis (6.07%. La familia Elmidae fue la más diversa con 11 géneros. Las pruebas no parametricas de Kruskall-Wallis para riqueza, abundancia, diversidad y equidad determinaron diferencias significativas (p< 0.05 entre los micro hábitat estudiados. El análisis de ordenamiento no paramétrico de escalamiento multidimensional nMDS y el análisis de similaridad ANOSIM, evidenciaron diferencias claras entre las muestras de micro hábitats.

  4. Discovery Mondays

    CERN Multimedia

    2003-01-01

    Many people don't realise quite how much is going on at CERN. Would you like to gain first-hand knowledge of CERN's scientific and technological activities and their many applications? Try out some experiments for yourself, or pick the brains of the people in charge? If so, then the «Lundis Découverte» or Discovery Mondays, will be right up your street. Starting on May 5th, on every first Monday of the month you will be introduced to a different facet of the Laboratory. CERN staff, non-scientists, and members of the general public, everyone is welcome. So tell your friends and neighbours and make sure you don't miss this opportunity to satisfy your curiosity and enjoy yourself at the same time. You won't have to listen to a lecture, as the idea is to have open exchange with the expert in question and for each subject to be illustrated with experiments and demonstrations. There's no need to book, as Microcosm, CERN's interactive museum, will be open non-stop from 7.30 p.m. to 9 p.m. On the first Discovery M...

  5. Caracterización fisicoquímica y biológica de la calidad de aguas de la cuenca de la quebrada Piedras Blancas, Antioquia, Colombia

    Directory of Open Access Journals (Sweden)

    José A. Posada G.

    2000-03-01

    Full Text Available Entre abril y diciembre de 1996, se llevó a cabo un estudio limnológico de 17 quebradas ubicada en el área del Parque Piedras Blancas (6° 8' 20''N, 75° 30' 20''Wlocalizado al SE de Medellín a 2 400 m de altura. El estudio se realizó en 35 estaciones de muestreo y se establecieron tres períodos de muestreo: el primero entre abril y mayo, el segundo de agosto a septiembre y el tercero de octubre a diciembre de 1996. La finalidad del mismo era establecer la calidad ecológica de las aguas ubicadas en el área del Parque. Para la recolección cualitativa de los macroinvertebrados se utilizaron las redes D-net y de pantalla. El área de muestreo en cada estación fue de 6 m2. Las variables fisicoquímicas mostraron fluctuaciones bajas a lo largo del estudio, excepto la conductividad y los sólidos totales, cuyos cambios estuvieron relacionados con la alta pluviosidad durante el período de estudio. La comunidad de macroinvertebrados encontrada, estuvo conformada por 113 géneros, pertenecientes a 63 familias y siete Phyla, siendo el orden Tichoptera el más abundante. El área de muestreo en cada estación fue de 6 m². El resultado del estudio muestra como la cuenca de la quebrada Piedras Blancas presenta condiciones que pueden clasificarse en términos generales como oligo-mesotróficas.From April to December 1996 a limnological study was carried out in 17 streams near Medellín, in order to stablish their water quality. The area is located in Piedras Blancas Park (6° 8' 20''N, 75° 30' 20''W SE of Medellín at 2 400 m altitude. Three sampling periods, encompasing wet and dry seasons were selected: April-May, August-September and October-December. For qualitative collection methods hand screen D-net were used. Each station was intensively sampled to collect most macroinvertebrates in all types of habitat. The area sampled in each station was 6 m². Physicochemical variables in general showed small fluctuations along the study; only

  6. Caracterización de la comunidad de macroinvertebrados de la Quebrada Paloblanco de la Cuenca del Río Otún (Risaralda, Colombia

    Directory of Open Access Journals (Sweden)

    Eleonora Bernal Pinilla

    2006-07-01

    Full Text Available Se realizó un estudio de las comunidades de macroinvertebrados presentes en la quebrada Paloblanco, ubicada en la cuenca del río Otún (Risaralda, Colombia. Los puntos de muestreo seleccionados corresponden a la cabecera y la zona cercana a la desembocadura en el río Otún, ambos con características geomorfológicas de corrientes de primer orden. En cada punto se colectaron los macroinvertebrados de las unidades funcionales hojarasca, epiliton, musgo y grava, junto con una muestra de deriva y fauna general (sin discriminar unidad funcional. Se encontraron 42 familias de Insecta, además de Acari, Annelida, Crustacea e Hirudinea. Igualmente se encontraron familias de presencia exclusiva en cada punto, mostrando diferencias en la composición de las comunidades. Los índices ecológicos empleados mostraron una mayor diversidad en punto bajo y diferencias entre algunas de las unidades funcionales, relacionados con el medio y los hábitos presentes. Para el análisis se tuvieron en cuenta los conceptos de continuo y zonación de los ríos. A pesar de tener condiciones de primer orden, existen variaciones a pequeña escala entre los puntos de muestreo, que están relacionadas con la intervención antrópica en la zona aledaña a punto bajo.

  7. CARACTERIZACIÓN DE LA COMUNIDAD DE MACROINVERTEBRADOS DE LA QUEBRADA PALOBLANCO DE LA CUENCA DEL RÍO OTÚN (RISARALDA, COLOMBIA) Characterization of the Macroinvertebrate Community of Paloblanco Gulch, Otun River Basin

    OpenAIRE

    ELEONORA BERNAL; DUBERNEY GARCÍA; MIGUEL A NOVOA; ATTICUS PINZÓN

    2006-01-01

    Se realizó un estudio de las comunidades de macroinvertebrados presentes en la quebrada Paloblanco, ubicada en la cuenca del río Otún (Risaralda, Colombia). Los puntos de muestreo seleccionados corresponden a la cabecera y la zona cercana a la desembocadura en el río Otún, ambos con características geomorfológicas de corrientes de primer orden. En cada punto se colectaron los macroinvertebrados de las unidades funcionales hojarasca, epiliton, musgo y grava, junto con una muestra de deriva y f...

  8. Humedad crítica y repelencia al agua en andisoles bajo cobertura de cupressus lusitanica y quercus humboldtii en la cuenca de la quebrada piedras blancas (medellín, colombia).

    OpenAIRE

    Caballero Mejía, Bibiana; Jaramillo Jaramillo, Daniel Francisco

    2011-01-01

    En dos vertientes de la cuenca de la quebrada Piedras Blancas (Medellín, Colombia) se estudió la relación humedad – persistencia de la repelencia al agua en la parte superficial de andisoles bajo dos coberturas vegetales: Cupressus lusitanica (ciprés) y Quercus humboldtii (roble), en tres posiciones a lo largo de la vertiente de colinas bajas: superior, media e inferior y en dos condiciones de humedad: con la humedad de campo y con la humedad adquirida al equilibrar al aire durante dos días m...

  9. Quebrada La Popala: un análisis de calidad del agua desde algunas variables fisicoquímicas, microbiológicas y los macroinvertebrados acuáticos

    Directory of Open Access Journals (Sweden)

    Milán Valoyes Wandy Yohanna

    2011-11-01

    Full Text Available La quebrada La Popala es la fuente que abastece de agua a los habitantes del corregimiento de Bolombolo en Venecia, Antioquia, Colombia. En noviembre 14 y 28 de 2009, se ubicaron cuatro estaciones de muestreo, donde se aplicaron y analizaron variables fi sicoquímicas, indicadores biológicos, variables microbiológicas, macroinvertebrados acuáticos y el índice biótico BMWP. Las variables fi sicoquímicas, los macroinvertebrados acuáticos y el índice BMWP indican mejores condiciones ambientales en la estación 2, ubicada a unos 150 m del nacimiento de la quebrada (estación 1, mientras que la estación 4, establecida cerca de la desembocadura al río Cauca, exhibe un deterioro del agua. Las estaciones 3 y 4 presentaron niveles altos de coliformes fecales, con un número mayor en la 4. No obstante, los resultados de las muestras tomadas de la red de distribución de agua potable del corregimiento de Bolombolo indican que el agua proveniente del acueducto presenta condiciones aptas para el consumo humano.

  10. Use of fog water to the initial establishment of tree species under conditions of barren Lomas in the Quebrada Topará, Chincha-Perú

    Science.gov (United States)

    Vargas, A.; Cabrera, R.; Bederski, K.; Orellana, A.

    2010-07-01

    The Quebrada Topara is located in the Peruvian coastal desert (13012'L.S, 76009'L.W.) and is influenced by the fog during the winter months, these conditions of high humidity allows its use to achieve the establishment of a permanent vegetation cover Huaquina hill, which is representative at the place of study. Uncounted fog water can be captured and used for irrigation of plants. Also due to the absence of any tree species coverage in this region is not known which or which could have a better performance under these environmental conditions, We used to native species Caesalpinia spinosa "tara" and Schinus molle "molle" also introduced species Casuarina equisetifolia "Casuarina", as these could have a better adaptation. Soil analysis determined a high salinity and nitrogen poverty, preventing water infiltration into the soil and is not used by the plant so that the saline soil difficult to establish plants. This research can be considered an exploratory phase, the objectives were: to determine the potential for fog water harvesting to capture in the study area, to assess for 20 months the initial performance of the species tara, molle and casuarina, and profit incorporation in the final sowing of organic matter and soil amendments to facilitate a better development of plants. 3 standard fog collector (SFC) proposed by Schemenauer and Cereceda (1993) were installed and we evaluated the capture water during 31 months, from June 2007 to December 2009, finding much water collected in the winter months, the average annual in the 3 SFC was similar (1.1, 1.2 and 1.1 L m -2 day-1) which allows us to plan according to necessary the best way to harness and store water to supply the plants. It was found that native species, tara and molle were more adaptable to extreme conditions of the place that introduced casuarina species. The tara does grow faster in height and stem diameter, also achieves a good coverage to intercept fog water itself making it more viable and capable

  11. Caracterización morfométrica de la microcuenca de la quebrada los Andes, El Carmen de Viboral, Antioquia-Colombia Morphometrical characterization in los Andes watershed, El Carmen de Viboral, Antioquia-Colombia

    Directory of Open Access Journals (Sweden)

    Yimmy Montoya Moreno

    2009-07-01

    Full Text Available Se evaluaron algunas características morfométricas básicas en la microcuenca de la quebrada Los Andes en el departamento de Antioquia (Colombia. La microcuenca tiene un área pequeña (Some morphometric characteristic were evaluated in the watershed of creek Los Andes department of Antioquia (Colombia. The headwater has a small area (<20km² with main direction in the axis S-N, with an elevation range between 2.700 and 2.200 m. asl. It presents a network of drainage well structured, for which presents a time of concentration of the water over 5 hours. The watershed is of class Kc2 with a high slope and a system of drainage subdendritic. This research permitted to identify the uses of the soil, being the adequate use the one that presented greater percentage (55% and the use is recommended conservationist in general for all headwater.

  12. Environmental management to preserve the tourist potential on the basis of hydric supply of alluvial soil terracing, between Quebrada Seca, La Nuarque and the Cauca River, Municipality of Olaya, Department of Antioquia

    International Nuclear Information System (INIS)

    Henao, Leonardo de Jesus; Obregon R, Gerardo

    2007-01-01

    It is predict changes on the soils uses at the tourist zone of the right margin of Cauca river, Olaya village, department of Antioquia, republic of Colombia: La Florida and Quebrada Seca sectors, this is the consequence of the growth of tourist population generated by the opening of the Tunel de Occidente. The study area is between the streams: La Seca, La Nuarque and the Cauca river, it has 1367 hectares. The work contemplates to carry out of a hidric balance, the projection of population and its hidric requires to the year 2016, on the basis of the previous ideas it was defined: the offer-demand relation at the year 2016 and the instructive to the environmental management for the conservation, optimization and use of the hidric resources and the environmental arrangement of the territory, reasonable to the density of houses in agreement with the soil's potentials

  13. Usability of Discovery Portals

    OpenAIRE

    Bulens, J.D.; Vullings, L.A.E.; Houtkamp, J.M.; Vanmeulebrouk, B.

    2013-01-01

    As INSPIRE progresses to be implemented in the EU, many new discovery portals are built to facilitate finding spatial data. Currently the structure of the discovery portals is determined by the way spatial data experts like to work. However, we argue that the main target group for discovery portals are not spatial data experts but professionals with limited spatial knowledge, and a focus outside the spatial domain. An exploratory usability experiment was carried out in which three discovery p...

  14. Diagnóstico de situación de la equinococosis quística en heces dispersas en las zonas de Quebrada y Puna, provincia de Jujuy, Argentina

    Directory of Open Access Journals (Sweden)

    Silvia Frison de Costas

    Full Text Available La equinococosis es una enfermedad parasitaria común en el ganado, causada por el cestode Echinococcus granulosus; el perro es su principal hospedador definitivo. La provincia de Jujuy es un área endémica, situada en el ángulo noroeste de la República Argentina. Las condiciones ecológicas restringidas de Quebrada y Puna hacen que la actividad más importante de la población sea la pecuaria formal pastoril y trashumante, especialmente dedicada a ovinos y camélidos. El perro adquiere en estas comunidades una doble función de compañía y como pastor. El objetivo del presente estudio fue realizar un diagnóstico de situación en las áreas de Quebrada y Puna, donde se sospecha que hay circulación de E. granulosus. Desde 2002 hasta 2012 se recolectaron 523 muestras de materia fecal de canino dispersas en el ambiente. Las prevalencias variaron desde un 2 % en Susques hasta un 27,7 % (la mayor de la provincia en Humahuaca. Tumbaya presentó una prevalencia del 21 % en 2007, llegó a 0 % en 2010, pero volvió a aumentar al 10,5 % en 2011. La disminución observada durante 2010 puede explicarse en el hecho de que las muestras se tomaron en localidades donde se había realizado educación sanitaria previamente. En el resto de las regiones estudiadas se observaron prevalencias entre 2 % y 19,4 %. Estos resultados sugieren que la falta de estrategias para el control de la equinococosis ha permitido la dispersión de la enfermedad.

  15. Usability of Discovery Portals

    NARCIS (Netherlands)

    Bulens, J.D.; Vullings, L.A.E.; Houtkamp, J.M.; Vanmeulebrouk, B.

    2013-01-01

    As INSPIRE progresses to be implemented in the EU, many new discovery portals are built to facilitate finding spatial data. Currently the structure of the discovery portals is determined by the way spatial data experts like to work. However, we argue that the main target group for discovery portals

  16. Discovery and the atom

    International Nuclear Information System (INIS)

    1989-01-01

    ''Discovery and the Atom'' tells the story of the founding of nuclear physics. This programme looks at nuclear physics up to the discovery of the neutron in 1932. Animation explains the science of the classic experiments, such as the scattering of alpha particles by Rutherford and the discovery of the nucleus. Archive film shows the people: Lord Rutherford, James Chadwick, Marie Curie. (author)

  17. Topology Discovery Using Cisco Discovery Protocol

    OpenAIRE

    Rodriguez, Sergio R.

    2009-01-01

    In this paper we address the problem of discovering network topology in proprietary networks. Namely, we investigate topology discovery in Cisco-based networks. Cisco devices run Cisco Discovery Protocol (CDP) which holds information about these devices. We first compare properties of topologies that can be obtained from networks deploying CDP versus Spanning Tree Protocol (STP) and Management Information Base (MIB) Forwarding Database (FDB). Then we describe a method of discovering topology ...

  18. Service Discovery At Home

    NARCIS (Netherlands)

    Sundramoorthy, V.; Scholten, Johan; Jansen, P.G.; Hartel, Pieter H.

    Service discovery is a fady new field that kicked off since the advent of ubiquitous computing and has been found essential in the making of intelligent networks by implementing automated discovery and remote control between deviies. This paper provides an ovewiew and comparison of several prominent

  19. Academic Drug Discovery Centres

    DEFF Research Database (Denmark)

    Kirkegaard, Henriette Schultz; Valentin, Finn

    2014-01-01

    Academic drug discovery centres (ADDCs) are seen as one of the solutions to fill the innovation gap in early drug discovery, which has proven challenging for previous organisational models. Prior studies of ADDCs have identified the need to analyse them from the angle of their economic...

  20. Decades of Discovery

    Science.gov (United States)

    2011-06-01

    For the past two-and-a-half decades, the Office of Science at the U.S. Department of Energy has been at the forefront of scientific discovery. Over 100 important discoveries supported by the Office of Science are represented in this document.

  1. Service discovery at home

    NARCIS (Netherlands)

    Sundramoorthy, V.; Scholten, Johan; Jansen, P.G.; Hartel, Pieter H.

    2003-01-01

    Service discovery is a fairly new field that kicked off since the advent of ubiquitous computing and has been found essential in the making of intelligent networks by implementing automated discovery and remote control between devices. This paper provides an overview and comparison of several

  2. "Eureka, Eureka!" Discoveries in Science

    Science.gov (United States)

    Agarwal, Pankaj

    2011-01-01

    Accidental discoveries have been of significant value in the progress of science. Although accidental discoveries are more common in pharmacology and chemistry, other branches of science have also benefited from such discoveries. While most discoveries are the result of persistent research, famous accidental discoveries provide a fascinating…

  3. The Greatest Mathematical Discovery?

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, David H.; Borwein, Jonathan M.

    2010-05-12

    What mathematical discovery more than 1500 years ago: (1) Is one of the greatest, if not the greatest, single discovery in the field of mathematics? (2) Involved three subtle ideas that eluded the greatest minds of antiquity, even geniuses such as Archimedes? (3) Was fiercely resisted in Europe for hundreds of years after its discovery? (4) Even today, in historical treatments of mathematics, is often dismissed with scant mention, or else is ascribed to the wrong source? Answer: Our modern system of positional decimal notation with zero, together with the basic arithmetic computational schemes, which were discovered in India about 500 CE.

  4. Aproximación a La Caracterización Ecológica de La Quebrada Fucha en La Reserva Forestal de los Cerros Orientales en La Localidad de San Cristóbal. (Bogotá, Colombia

    Directory of Open Access Journals (Sweden)

    Mónica Restrepo Villamil (Página 96-113

    2009-07-01

    Full Text Available En este trabajo se presentan los resultados obtenidos en la práctica de campo realizada el día 10 de octubre de 2008, en la quebrada Fucha en una reserva forestal protegida por la Empresa de Acueducto y Alcantarillado de Bogotá en los cerros orientales de la localidad de San Cristóbal. El objetivo principal de este estudio fue realizar una aproximación a la caracterización de este sistema acuático, para lo cual, se colectaron insectos acuáticos (entomofauna y perifiton, se caracterizaron los suelos de la ribera y se realizaron análisis de las variables fisicoquímicas de la zona. Los insectos acuáticos que se encontraron sumaron un total de 188 individuos, en donde las familias más abundantes fueron Simuliidae y Ceratopogonidae con 60 individuos cada una (32% c/u y las de menor abundancia fueron Odontoceridae, Lepharoceridae y Pyralidae con 1 individuo c/u (0.53% c/u; por otra parte, se encontraron 14 géneros de perifiton. El sistema presenta una diversidad media de acuerdo al índice de Shannon (1.55. La principal fuente de energía del sistema es la materia orgánica disuelta, por lo que la vía que predomina es la detrítica.

  5. Multidimensional process discovery

    NARCIS (Netherlands)

    Ribeiro, J.T.S.

    2013-01-01

    Typically represented in event logs, business process data describe the execution of process events over time. Business process intelligence (BPI) techniques such as process mining can be applied to get strategic insight into business processes. Process discovery, conformance checking and

  6. Fateful discovery almost forgotten

    CERN Multimedia

    1989-01-01

    "The discovery of the fission of uranium exactly half a century ago is at risk of passing unremarked because of the general ambivalence towards the consequences of this development. Can that be wise?" (4 pages)

  7. Toxins and drug discovery.

    Science.gov (United States)

    Harvey, Alan L

    2014-12-15

    Components from venoms have stimulated many drug discovery projects, with some notable successes. These are briefly reviewed, from captopril to ziconotide. However, there have been many more disappointments on the road from toxin discovery to approval of a new medicine. Drug discovery and development is an inherently risky business, and the main causes of failure during development programmes are outlined in order to highlight steps that might be taken to increase the chances of success with toxin-based drug discovery. These include having a clear focus on unmet therapeutic needs, concentrating on targets that are well-validated in terms of their relevance to the disease in question, making use of phenotypic screening rather than molecular-based assays, and working with development partners with the resources required for the long and expensive development process. Copyright © 2014 The Author. Published by Elsevier Ltd.. All rights reserved.

  8. Defining Creativity with Discovery

    OpenAIRE

    Wilson, Nicholas Charles; Martin, Lee

    2017-01-01

    The standard definition of creativity has enabled significant empirical and theoretical advances, yet contains philosophical conundrums concerning the nature of novelty and the role of recognition and values. In this work we offer an act of conceptual valeting that addresses these issues and in doing so, argue that creativity definitions can be extended through the use of discovery. Drawing on dispositional realist philosophy we outline why adding the discovery and bringing into being of new ...

  9. On the antiproton discovery

    International Nuclear Information System (INIS)

    Piccioni, O.

    1989-01-01

    The author of this article describes his own role in the discovery of the antiproton. Although Segre and Chamberlain received the Nobel Prize in 1959 for its discovery, the author claims that their experimental method was his idea which he communicated to them informally in December 1954. He describes how his application for citizenship (he was Italian), and other scientists' manipulation, prevented him from being at Berkeley to work on the experiment himself. (UK)

  10. Discovery Driven Growth

    DEFF Research Database (Denmark)

    Bukh, Per Nikolaj

    2009-01-01

    Anmeldelse af Discovery Driven Growh : A breakthrough process to reduce risk and seize opportunity, af Rita G. McGrath & Ian C. MacMillan, Boston: Harvard Business Press. Udgivelsesdato: 14 august......Anmeldelse af Discovery Driven Growh : A breakthrough process to reduce risk and seize opportunity, af Rita G. McGrath & Ian C. MacMillan, Boston: Harvard Business Press. Udgivelsesdato: 14 august...

  11. The π discovery

    International Nuclear Information System (INIS)

    Fowler, P.H.

    1988-01-01

    The paper traces the discovery of the Π meson. The discovery was made by exposure of nuclear emulsions to cosmic radiation at high altitudes, with subsequent scanning of the emulsions for meson tracks. Disintegration of nuclei by a negative meson, and the decay of a Π meson were both observed. Further measurements revealed the mass of the meson. The studies carried out on the origin of the Π-mesons, and their mode of decay, are both described. (U.K.)

  12. Discovery of charm

    International Nuclear Information System (INIS)

    Goldhaber, G.

    1984-11-01

    In my talk I will cover the period 1973 to 1976 which saw the discoveries of the J/psi and psi' resonances and most of the Psion spectroscopy, the tau lepton and the D 0 ,D + charmed meson doublet. Occasionally I will refer briefly to more recent results. Since this conference is on the history of the weak-interactions I will deal primarily with the properties of naked charm and in particular the weakly decaying doublet of charmed mesons. Most of the discoveries I will mention were made with the SLAC-LBL Magnetic Detector or MARK I which we operated at SPEAR from 1973 to 1976. 27 references

  13. Aplicación de los índices NSF, DINIUS y BMWP para el análisis de la calidad de agua de la Quebrada La Ayurá, Antioquia Colombia

    Directory of Open Access Journals (Sweden)

    Orlando Caicedo Quintero

    2013-06-01

    Full Text Available En esta investigación se evaluó la calidad de agua de la quebrada la Ayurá en Envigado- Antioquia  Colombia, mediante la aplicación de los índices de Calidad de la Fundación Nacional de Saneamiento (INSF, de calidad de Dinius y el índice biótico BMWP. La estimación de estos índices se efectuó con información recolectada en tres sitios durante tres muestreos. Se determinaron variables fisicoquímicas y microbiológicas, además se realizaron muestreos cualitativos y cuantitativos de macroinvertebrados acuáticos.                                                                                                                                                                                                                                                                                                                              El empleo de esta metodología permitió conocer el comportamiento fisicoquímico y de la comunidad biológica en los diferentes sitios. Los resultados fisicoquímicos, microbiológicos, macroinvertebrados acuáticos y de los índices indicaron que en la estación 1 se presenta una buena calidad del agua y en las estaciones 2 y 3  un deterioro medio de la calidad del agua. PALABRAS CLAVES: Quebrada la Ayurá, Calidad del agua, Índices de calidad, Índices bióticos, oxigeno disuelto, macroinvertebrados acuáticos. 

  14. Mapifcación y analisis de la distribución espacial de organismos indicadores de la calidad del agua en la quebrada la Ayurá (Envigado, Antioquia

    Directory of Open Access Journals (Sweden)

    Guerra Rojas Adriana

    2011-11-01

    Full Text Available Esta investigación evalúa y analiza la distribución espacial de las comunidades de perifi ton y macroinvertebrados acuáticos utilizados en la determinación de la calidad del agua, considerando los trabajos realizados previamente por el grupo GAIA de la Universidad de Antioquia sobre la Quebrada Ayurá. Se emplearon las funciones de modelos hidrológicos, preestablecidos en la herramienta SIG, con las cuales se realizó el trazado de la red de corriente. A través de la superposición de capas temáticas, se obtuvo una herramienta cartográfi ca que permitió determinar la relación entre los usos del suelo dados a las zonas aledañas donde se ubicaron las estaciones de muestreo y la población de organismos colectados e identifi cados en cada punto. Los resultados obtenidos permiten decir que tanto las comunidades de protistas y macroinvertebrados acuáticos, como los índices establecidos, BMWP Colombia, Dinius e INSF, señalan una buena calidad del recurso hídrico para la estación 1, en donde se presentan bosques de coníferas, rastrojos altos y bajos; en la estación 2 se tiene una calidad aceptable, y allí se observan algunas construcciones, pastos y monocultivos; fi nalmente en la estación 3, ubicada en la zona urbana, la calidad es inferior a las anteriores estaciones.

  15. Discovery: Pile Patterns

    Science.gov (United States)

    de Mestre, Neville

    2017-01-01

    Earlier "Discovery" articles (de Mestre, 1999, 2003, 2006, 2010, 2011) considered patterns from many mathematical situations. This article presents a group of patterns used in 19th century mathematical textbooks. In the days of earlier warfare, cannon balls were stacked in various arrangements depending on the shape of the pile base…

  16. Discovery and Innovation

    African Journals Online (AJOL)

    Discovery and Innovation is a journal of the African Academy of Sciences (AAS) ... World (TWAS) meant to focus attention on science and technology in Africa and the ... of Non-wood Forest Products: Potential Impacts and Challenges in Africa ...

  17. Discovery of TUG-770

    DEFF Research Database (Denmark)

    Christiansen, Elisabeth; Hansen, Steffen V F; Urban, Christian

    2013-01-01

    Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist with favorable physicochemical...

  18. The discovery of fission

    International Nuclear Information System (INIS)

    McKay, H.A.C.

    1978-01-01

    In this article by the retired head of the Separation Processes Group of the Chemistry Division, Atomic Energy Research Establishment, Harwell, U.K., the author recalls what he terms 'an exciting drama, the unravelling of the nature of the atomic nucleus' in the years before the Second World War, including the discovery of fission. 12 references. (author)

  19. The Discovery of America

    Science.gov (United States)

    Martin, Paul S.

    1973-01-01

    Discusses a model for explaining the spread of human population explosion on North American continent since its discovery 12,000 years ago. The model may help to map the spread of Homo sapiens throughout the New World by using the extinction chronology of the Pleistocene megafauna. (Author/PS)

  20. The neutron discovery

    International Nuclear Information System (INIS)

    Six, J.

    1987-01-01

    The neutron: who had first the idea, who discovered it, who established its main properties. To these apparently simple questions, multiple answers exist. The progressive discovery of the neutron is a marvellous illustration of some characteristics of the scientific research, where the unforeseen may be combined with the expected. This discovery is replaced in the context of the 1930's scientific effervescence that succeeded the revolutionary introduction of quantum mechanics. This book describes the works of Bothe, the Joliot-Curie and Chadwick which led to the neutron in an unexpected way. A historical analysis allows to give a new interpretation on the hypothesis suggested by the Joliot-Curie. Some texts of these days will help the reader to revive this fascinating story [fr

  1. Atlas of Astronomical Discoveries

    CERN Document Server

    Schilling, Govert

    2011-01-01

    Four hundred years ago in Middelburg, in the Netherlands, the telescope was invented. The invention unleashed a revolution in the exploration of the universe. Galileo Galilei discovered mountains on the Moon, spots on the Sun, and moons around Jupiter. Christiaan Huygens saw details on Mars and rings around Saturn. William Herschel discovered a new planet and mapped binary stars and nebulae. Other astronomers determined the distances to stars, unraveled the structure of the Milky Way, and discovered the expansion of the universe. And, as telescopes became bigger and more powerful, astronomers delved deeper into the mysteries of the cosmos. In his Atlas of Astronomical Discoveries, astronomy journalist Govert Schilling tells the story of 400 years of telescopic astronomy. He looks at the 100 most important discoveries since the invention of the telescope. In his direct and accessible style, the author takes his readers on an exciting journey encompassing the highlights of four centuries of astronomy. Spectacul...

  2. Viral pathogen discovery

    Science.gov (United States)

    Chiu, Charles Y

    2015-01-01

    Viral pathogen discovery is of critical importance to clinical microbiology, infectious diseases, and public health. Genomic approaches for pathogen discovery, including consensus polymerase chain reaction (PCR), microarrays, and unbiased next-generation sequencing (NGS), have the capacity to comprehensively identify novel microbes present in clinical samples. Although numerous challenges remain to be addressed, including the bioinformatics analysis and interpretation of large datasets, these technologies have been successful in rapidly identifying emerging outbreak threats, screening vaccines and other biological products for microbial contamination, and discovering novel viruses associated with both acute and chronic illnesses. Downstream studies such as genome assembly, epidemiologic screening, and a culture system or animal model of infection are necessary to establish an association of a candidate pathogen with disease. PMID:23725672

  3. Fateful discovery almost forgotten

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    The paper reviews the discovery of the fission of uranium, which took place fifty years ago. A description is given of the work of Meitner and Frisch in interpreting the Fermi data on the bombardment of uranium nuclei with neutrons, i.e. proposing fission. The historical events associated with the development and exploitation of uranium fission are described, including the Manhattan Project, Hiroshima and Nagasaki, Shippingport, and Chernobyl. (U.K.)

  4. Discovery as a process

    Energy Technology Data Exchange (ETDEWEB)

    Loehle, C.

    1994-05-01

    The three great myths, which form a sort of triumvirate of misunderstanding, are the Eureka! myth, the hypothesis myth, and the measurement myth. These myths are prevalent among scientists as well as among observers of science. The Eureka! myth asserts that discovery occurs as a flash of insight, and as such is not subject to investigation. This leads to the perception that discovery or deriving a hypothesis is a moment or event rather than a process. Events are singular and not subject to description. The hypothesis myth asserts that proper science is motivated by testing hypotheses, and that if something is not experimentally testable then it is not scientific. This myth leads to absurd posturing by some workers conducting empirical descriptive studies, who dress up their study with a ``hypothesis`` to obtain funding or get it published. Methods papers are often rejected because they do not address a specific scientific problem. The fact is that many of the great breakthroughs in silence involve methods and not hypotheses or arise from largely descriptive studies. Those captured by this myth also try to block funding for those developing methods. The third myth is the measurement myth, which holds that determining what to measure is straightforward, so one doesn`t need a lot of introspection to do science. As one ecologist put it to me ``Don`t give me any of that philosophy junk, just let me out in the field. I know what to measure.`` These myths lead to difficulties for scientists who must face peer review to obtain funding and to get published. These myths also inhibit the study of science as a process. Finally, these myths inhibit creativity and suppress innovation. In this paper I first explore these myths in more detail and then propose a new model of discovery that opens the supposedly miraculous process of discovery to doser scrutiny.

  5. 14 CFR 406.143 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Discovery. 406.143 Section 406.143... Transportation Adjudications § 406.143 Discovery. (a) Initiation of discovery. Any party may initiate discovery... after a complaint has been filed. (b) Methods of discovery. The following methods of discovery are...

  6. Olivine-hornblende-lamprophyre dikes from Quebrada los Sapos, El Teniente, Central Chile (34°S: implications for the temporal geochemical evolution of the Andean subarc mantle Diques lamprofídicos de olivino-hornblenda de la quebrada los Sapos, El Teniente, Chile central (34°S: implicancias para la evolución temporal de la geoquímica del manto subarco Andino

    Directory of Open Access Journals (Sweden)

    Charles R Stern

    2011-01-01

    Full Text Available Mafic Mg-olivine (Fo884-hornblende lamprophyre dikes, with Ni -190 ppm and Cr -390 ppm, cut late Miocene lavas in the Quebrada los Sapos a few kilometers west of the El Teniente Cu-Mo mine. These dikes have petro-chemical affinities with other less primitive, Pliocene (2.9-3.9 Ma, olivine-free lamprophyres previously described from both within and in the vicinity of El Teniente. The mafic mantle-derived lamprophyre dikes from Quebrada los Sapos have La/Yb ratios of 10-13, higher than the ratios of 4-9 for older Late Miocene El Teniente Mafic Complex olivine basalts, suggesting a temporal decrease in the percent of partial mantle melting, consistent with the observed decrease in the volume of igneous rocks through time at this latitude, as well as the ultímate cessation of magmatism and >40 km eastward are migration by the Late Pliocene. Less primitive olivine-free lamprophyres have higher La and lower Yb, resulting in higher La/Yb ratios of 15-44, due to crystal-liquid fractionation involving hornblende, but not plagioclase, the crystallization of which is suppressed by the high H2O contents of the lamprophyres. The lamprophyre dikes, as well as younger (1.8-2.3 Ma olivine-bearing basaltic-andesite lava flows in the valley of the Cachapoal river, have 87Sr/86Sr=0.7041 to 0.7049, or = +1.2 to -1.1 and 206Pb/204Pb=18.60 to 18.68, while Middle to Late Miocene (6.5-13.9 Ma El Teniente Volcanic and Plutonic Complex igneous rocks have lower 87Sr/86Sr=0.7039 to 0.7041 and 206Pb/204Pb=18.56 to 18.59, and higher G =+1.9 to +3.8, and older Oligocene to Early Miocene (>15 Ma Abanico or Coya-Machalí Formation volcanic and plutonic rocks in the region have even lower 87Sr/86Sr=0.7033 to 0.7039 and 206Pb/204Pb=18.45 to 18.57, and higher G Nd=+3.8 to +6.2. The data indicate a significant progressive temporal evolution, between the Oligocene and the Pliocene, to higher 87Sr/86Sr and 206Pb/204Pb, and lower for mantle-derived mafic magmas, and by implication

  7. Causality discovery technology

    Science.gov (United States)

    Chen, M.; Ertl, T.; Jirotka, M.; Trefethen, A.; Schmidt, A.; Coecke, B.; Bañares-Alcántara, R.

    2012-11-01

    Causality is the fabric of our dynamic world. We all make frequent attempts to reason causation relationships of everyday events (e.g., what was the cause of my headache, or what has upset Alice?). We attempt to manage causality all the time through planning and scheduling. The greatest scientific discoveries are usually about causality (e.g., Newton found the cause for an apple to fall, and Darwin discovered natural selection). Meanwhile, we continue to seek a comprehensive understanding about the causes of numerous complex phenomena, such as social divisions, economic crisis, global warming, home-grown terrorism, etc. Humans analyse and reason causality based on observation, experimentation and acquired a priori knowledge. Today's technologies enable us to make observations and carry out experiments in an unprecedented scale that has created data mountains everywhere. Whereas there are exciting opportunities to discover new causation relationships, there are also unparalleled challenges to benefit from such data mountains. In this article, we present a case for developing a new piece of ICT, called Causality Discovery Technology. We reason about the necessity, feasibility and potential impact of such a technology.

  8. Automated Supernova Discovery (Abstract)

    Science.gov (United States)

    Post, R. S.

    2015-12-01

    (Abstract only) We are developing a system of robotic telescopes for automatic recognition of Supernovas as well as other transient events in collaboration with the Puckett Supernova Search Team. At the SAS2014 meeting, the discovery program, SNARE, was first described. Since then, it has been continuously improved to handle searches under a wide variety of atmospheric conditions. Currently, two telescopes are used to build a reference library while searching for PSN with a partial library. Since data is taken every night without clouds, we must deal with varying atmospheric and high background illumination from the moon. Software is configured to identify a PSN, reshoot for verification with options to change the run plan to acquire photometric or spectrographic data. The telescopes are 24-inch CDK24, with Alta U230 cameras, one in CA and one in NM. Images and run plans are sent between sites so the CA telescope can search while photometry is done in NM. Our goal is to find bright PSNs with magnitude 17.5 or less which is the limit of our planned spectroscopy. We present results from our first automated PSN discoveries and plans for PSN data acquisition.

  9. Computational methods in drug discovery

    OpenAIRE

    Sumudu P. Leelananda; Steffen Lindert

    2016-01-01

    The process for drug discovery and development is challenging, time consuming and expensive. Computer-aided drug discovery (CADD) tools can act as a virtual shortcut, assisting in the expedition of this long process and potentially reducing the cost of research and development. Today CADD has become an effective and indispensable tool in therapeutic development. The human genome project has made available a substantial amount of sequence data that can be used in various drug discovery project...

  10. Representation Discovery using Harmonic Analysis

    CERN Document Server

    Mahadevan, Sridhar

    2008-01-01

    Representations are at the heart of artificial intelligence (AI). This book is devoted to the problem of representation discovery: how can an intelligent system construct representations from its experience? Representation discovery re-parameterizes the state space - prior to the application of information retrieval, machine learning, or optimization techniques - facilitating later inference processes by constructing new task-specific bases adapted to the state space geometry. This book presents a general approach to representation discovery using the framework of harmonic analysis, in particu

  11. Hippocampus discovery First steps

    Directory of Open Access Journals (Sweden)

    Eliasz Engelhardt

    Full Text Available The first steps of the discovery, and the main discoverers, of the hippocampus are outlined. Arantius was the first to describe a structure he named "hippocampus" or "white silkworm". Despite numerous controversies and alternate designations, the term hippocampus has prevailed until this day as the most widely used term. Duvernoy provided an illustration of the hippocampus and surrounding structures, considered the first by most authors, which appeared more than one and a half century after Arantius' description. Some authors have identified other drawings and texts which they claim predate Duvernoy's depiction, in studies by Vesalius, Varolio, Willis, and Eustachio, albeit unconvincingly. Considering the definition of the hippocampal formation as comprising the hippocampus proper, dentate gyrus and subiculum, Arantius and Duvernoy apparently described the gross anatomy of this complex. The pioneering studies of Arantius and Duvernoy revealed a relatively small hidden formation that would become one of the most valued brain structures.

  12. Materials Discovery | Materials Science | NREL

    Science.gov (United States)

    Discovery Materials Discovery Images of red and yellow particles NREL's research in materials characterization of sample by incoming beam and measuring outgoing particles, with data being stored and analyzed Staff Scientist Dr. Zakutayev specializes in design of novel semiconductor materials for energy

  13. Service discovery using Bloom filters

    NARCIS (Netherlands)

    Goering, P.T.H.; Heijenk, Geert; Lelieveldt, B.P.F.; Haverkort, Boudewijn R.H.M.; de Laat, C.T.A.M.; Heijnsdijk, J.W.J.

    A protocol to perform service discovery in adhoc networks is introduced in this paper. Attenuated Bloom filters are used to distribute services to nodes in the neighborhood and thus enable local service discovery. The protocol has been implemented in a discrete event simulator to investigate the

  14. On the pulse of discovery

    Science.gov (United States)

    2017-12-01

    What started 50 years ago as a `smudge' on paper has flourished into a fundamental field of astrophysics replete with unexpected applications and exciting discoveries. To celebrate the discovery of pulsars, we look at the past, present and future of pulsar astrophysics.

  15. Caracterización de la calidad de las aguas de la quebrada Fucha utilizando los índices de contaminación ICO con respecto a la precipitación y usos del suelo (Water quality characterization from creek Fucha using ICO pollution indices about precipitation and land use

    Directory of Open Access Journals (Sweden)

    Andrés Guillermo Chavarro

    2016-09-01

    Full Text Available Se presentan los resultados de la caracterización de la calidad de las aguas de la quebrada Fucha a través de los índices de contaminación ICO con respecto a los usos del suelo en diferentes épocas del año 2015. La quebrada se encuentra ubicada en la localidad de Usme, al suroriente de Bogotá (Colombia, en el límite urbano rural. Se midieron variables fisicoquímicas en seis muestreos y en tres puntos de la quebrada, se calcularon cuatro índices de contaminación (ICOMI, ICOMO, ICOSUS e ICOTRO; a estos se les realizó un análisis multivariado de correlación incluyendo la precipitación y los usos del suelo como variable indicador, se determinó el grado de correlación a través de regresiones simples para dos pares de variables. Adicionalmente se realizó un ANOVA con los usos del suelo y los valores obtenidos de los índices. No se encontró contaminación por mineralización y la quebrada en general presentó condiciones eutróficas, de igual manera se pudo establecer una correlación estadísticamente significativa entre la precipitación y el índice de contaminación trófica (ICOTRO, así como entre el índice de contaminación por sólidos suspendidos (ICOSUS e ICOTRO. Por su parte los usos del suelo no presentaron una correlación significativa con el aumento o disminución en el valor de los índices. (Abstract. The results of the characterization of the quality of water from the Fucha brook through ICO’s pollution indexes regarding land use at different times of the year are presented. The gorge is located in the town of Usme, in the urban-rural boundary. physic-chemical variables was measured in six samples and three points of the gorge, four indices of contamination (ICOMI, ICOMO, ICOSUS and ICOTRO were calculated, these were subjected to a multivariate correlation analysis including precipitation, it was determined the degree of correlation through simple regression for these two pairs of variables. In addition, an

  16. 29 CFR 2700.56 - Discovery; general.

    Science.gov (United States)

    2010-07-01

    ...(c) or 111 of the Act has been filed. 30 U.S.C. 815(c) and 821. (e) Completion of discovery... 29 Labor 9 2010-07-01 2010-07-01 false Discovery; general. 2700.56 Section 2700.56 Labor... Hearings § 2700.56 Discovery; general. (a) Discovery methods. Parties may obtain discovery by one or more...

  17. 19 CFR 207.109 - Discovery.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Discovery. 207.109 Section 207.109 Customs Duties... and Committee Proceedings § 207.109 Discovery. (a) Discovery methods. All parties may obtain discovery under such terms and limitations as the administrative law judge may order. Discovery may be by one or...

  18. 30 CFR 44.24 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Discovery. 44.24 Section 44.24 Mineral... Discovery. Parties shall be governed in their conduct of discovery by appropriate provisions of the Federal... discovery. Alternative periods of time for discovery may be prescribed by the presiding administrative law...

  19. 19 CFR 356.20 - Discovery.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Discovery. 356.20 Section 356.20 Customs Duties... § 356.20 Discovery. (a) Voluntary discovery. All parties are encouraged to engage in voluntary discovery... sanctions proceeding. (b) Limitations on discovery. The administrative law judge shall place such limits...

  20. 24 CFR 180.500 - Discovery.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Discovery. 180.500 Section 180.500... OPPORTUNITY CONSOLIDATED HUD HEARING PROCEDURES FOR CIVIL RIGHTS MATTERS Discovery § 180.500 Discovery. (a) In general. This subpart governs discovery in aid of administrative proceedings under this part. Discovery in...

  1. 15 CFR 25.21 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Discovery. 25.21 Section 25.21... Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for..., discovery is available only as ordered by the ALJ. The ALJ shall regulate the timing of discovery. (d...

  2. 39 CFR 963.14 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Discovery. 963.14 Section 963.14 Postal Service... PANDERING ADVERTISEMENTS STATUTE, 39 U.S.C. 3008 § 963.14 Discovery. Discovery is to be conducted on a... such discovery as he or she deems reasonable and necessary. Discovery may include one or more of the...

  3. 22 CFR 224.21 - Discovery.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Discovery. 224.21 Section 224.21 Foreign....21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of... parties, discovery is available only as ordered by the ALJ. The ALJ shall regulate the timing of discovery...

  4. Propuesta metodológica para el análisis morfo-sedimentológico en cuencas altamente urbanizadas: Caso de estudio quebrada Doña María (Colombia A methodological proposal to morph-sedimentologic analysis at urban basins: Case study: Doña Maria's basin

    Directory of Open Access Journals (Sweden)

    Juan Esteban González

    2010-01-01

    Full Text Available En este artículo se presenta una propuesta metodológica para hacer el análisis de morfología fluvial y transporte de sedimentos para cuencas altamente intervenidas por la acción humana. En dicha metodología se proponen diferentes actividades las cuales permitirán hacer un análisis detallado de la morfología fluvial y los sedimentos en una cuenca. Entre las etapas que se proponen para implementar esta metodología se tienen: análisis en planta de la cuenca, análisis de los perfiles altimétricos de las principales corrientes, levantamiento de información en campo (aforos líquidos, sólidos y observaciones generales de la morfología de la cuenca y estimación de la carga y capacidad de carga de sedimentos en la quebrada principal. Una aplicación a la cuenca de la quebrada Doña María (en el Área Metropolitana del Valle de Aburrá, Colombia es presentada.This paper shows a methodological proposal to carry out river morphology analysis and sediment transport for urban basins highly intervened by human actions. In this methodology, different activities that will allow doing a detailed analysis for the river morphology and sediment transport in the basin are proposed. Among the steps proposed to implement this methodology, there are: analysis in plant of little basin, altitude profiles analysis of the main sub-basins, field measures (measures of liquid and solid discharge and general observations of the basin morphology, and estimations of sediments load and bed load capacity in the stream. An application to basin of Doña María is showed.

  5. Discovery Mondays: Surveyors' Tools

    CERN Multimedia

    2003-01-01

    Surveyors of all ages, have your rulers and compasses at the ready! This sixth edition of Discovery Monday is your chance to learn about the surveyor's tools - the state of the art in measuring instruments - and see for yourself how they work. With their usual daunting precision, the members of CERN's Surveying Group have prepared some demonstrations and exercises for you to try. Find out the techniques for ensuring accelerator alignment and learn about high-tech metrology systems such as deviation indicators, tracking lasers and total stations. The surveyors will show you how they precisely measure magnet positioning, with accuracy of a few thousandths of a millimetre. You can try your hand at precision measurement using different types of sensor and a modern-day version of the Romans' bubble level, accurate to within a thousandth of a millimetre. You will learn that photogrammetry techniques can transform even a simple digital camera into a remarkable measuring instrument. Finally, you will have a chance t...

  6. 'The Lusiads', poem of discovery

    Directory of Open Access Journals (Sweden)

    Natasha Furlan Felizi

    2016-07-01

    Full Text Available The article proposes reading Os Lusíadas as a discovery journey. Discovery here read as aletheia or “revelation”, as proposed by Sophia de Mello Brey­ner Andresen in 1980. Using Martin Heidegger’s notion of aletheia in the book Parmenides along with Jorge de Sena and Sophia de Mello Breyner Andresen reflections on Camões, I’ll seek to point out alternative readings for Os Lusíadas as a “discovery journey”.

  7. Discovery of natural resources

    Science.gov (United States)

    Guild, P.W.

    1976-01-01

    Mankind will continue to need ores of more or less the types and grades used today to supply its needs for new mineral raw materials, at least until fusion or some other relatively cheap, inexhaustible energy source is developed. Most deposits being mined today were exposed at the surface or found by relatively simple geophysical or other prospecting techniques, but many of these will be depleted in the foreseeable future. The discovery of deeper or less obvious deposits to replace them will require the conjunction of science and technology to deduce the laws that governed the concentration of elements into ores and to detect and evaluate the evidence of their whereabouts. Great theoretical advances are being made to explain the origins of ore deposits and understand the general reasons for their localization. These advances have unquestionable value for exploration. Even a large deposit is, however, very small, and, with few exceptions, it was formed under conditions that have long since ceased to exist. The explorationist must suppress a great deal of "noise" to read and interpret correctly the "signals" that can define targets and guide the drilling required to find it. Is enough being done to ensure the long-term availability of mineral raw materials? The answer is probably no, in view of the expanding consumption and the difficulty of finding new deposits, but ingenuity, persistence, and continued development of new methods and tools to add to those already at hand should put off the day of "doing without" for many years. The possibility of resource exhaustion, especially in view of the long and increasing lead time needed to carry out basic field and laboratory studies in geology, geophysics, and geochemistry and to synthesize and analyze the information gained from them counsels against any letting down of our guard, however (17). Research and exploration by government, academia, and industry must be supported and encouraged; we cannot wait until an eleventh

  8. Supernovae Discovery Efficiency

    Science.gov (United States)

    John, Colin

    2018-01-01

    Abstract:We present supernovae (SN) search efficiency measurements for recent Hubble Space Telescope (HST) surveys. Efficiency is a key component to any search, and is important parameter as a correction factor for SN rates. To achieve an accurate value for efficiency, many supernovae need to be discoverable in surveys. This cannot be achieved from real SN only, due to their scarcity, so fake SN are planted. These fake supernovae—with a goal of realism in mind—yield an understanding of efficiency based on position related to other celestial objects, and brightness. To improve realism, we built a more accurate model of supernovae using a point-spread function. The next improvement to realism is planting these objects close to galaxies and of various parameters of brightness, magnitude, local galactic brightness and redshift. Once these are planted, a very accurate SN is visible and discoverable by the searcher. It is very important to find factors that affect this discovery efficiency. Exploring the factors that effect detection yields a more accurate correction factor. Further inquires into efficiency give us a better understanding of image processing, searching techniques and survey strategies, and result in an overall higher likelihood to find these events in future surveys with Hubble, James Webb, and WFIRST telescopes. After efficiency is discovered and refined with many unique surveys, it factors into measurements of SN rates versus redshift. By comparing SN rates vs redshift against the star formation rate we can test models to determine how long star systems take from the point of inception to explosion (delay time distribution). This delay time distribution is compared to SN progenitors models to get an accurate idea of what these stars were like before their deaths.

  9. RAS - Screens & Assays - Drug Discovery

    Science.gov (United States)

    The RAS Drug Discovery group aims to develop assays that will reveal aspects of RAS biology upon which cancer cells depend. Successful assay formats are made available for high-throughput screening programs to yield potentially effective drug compounds.

  10. Antibody informatics for drug discovery

    DEFF Research Database (Denmark)

    Shirai, Hiroki; Prades, Catherine; Vita, Randi

    2014-01-01

    to the antibody science in every project in antibody drug discovery. Recent experimental technologies allow for the rapid generation of large-scale data on antibody sequences, affinity, potency, structures, and biological functions; this should accelerate drug discovery research. Therefore, a robust bioinformatic...... infrastructure for these large data sets has become necessary. In this article, we first identify and discuss the typical obstacles faced during the antibody drug discovery process. We then summarize the current status of three sub-fields of antibody informatics as follows: (i) recent progress in technologies...... for antibody rational design using computational approaches to affinity and stability improvement, as well as ab-initio and homology-based antibody modeling; (ii) resources for antibody sequences, structures, and immune epitopes and open drug discovery resources for development of antibody drugs; and (iii...

  11. Discovery of the iron isotopes

    International Nuclear Information System (INIS)

    Schuh, A.; Fritsch, A.; Heim, M.; Shore, A.; Thoennessen, M.

    2010-01-01

    Twenty-eight iron isotopes have been observed so far and the discovery of these isotopes is discussed here. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  12. Discovery of the silver isotopes

    International Nuclear Information System (INIS)

    Schuh, A.; Fritsch, A.; Ginepro, J.Q.; Heim, M.; Shore, A.; Thoennessen, M.

    2010-01-01

    Thirty-eight silver isotopes have been observed so far and the discovery of these isotopes is discussed here. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  13. Synthetic biology of antimicrobial discovery

    Science.gov (United States)

    Zakeri, Bijan; Lu, Timothy K.

    2012-01-01

    Antibiotic discovery has a storied history. From the discovery of penicillin by Sir Alexander Fleming to the relentless quest for antibiotics by Selman Waksman, the stories have become like folklore, used to inspire future generations of scientists. However, recent discovery pipelines have run dry at a time when multidrug resistant pathogens are on the rise. Nature has proven to be a valuable reservoir of antimicrobial agents, which are primarily produced by modularized biochemical pathways. Such modularization is well suited to remodeling by an interdisciplinary approach that spans science and engineering. Herein, we discuss the biological engineering of small molecules, peptides, and non-traditional antimicrobials and provide an overview of the growing applicability of synthetic biology to antimicrobials discovery. PMID:23654251

  14. Discovery of the cadmium isotopes

    International Nuclear Information System (INIS)

    Amos, S.; Thoennessen, M.

    2010-01-01

    Thirty-seven cadmium isotopes have been observed so far and the discovery of these isotopes is discussed here. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  15. Discoveries of isotopes by fission

    Indian Academy of Sciences (India)

    country of discovery as well as the production mechanism used to produce the isotopes. ... the disintegration products of bombarded uranium, as a consequence of a ..... advanced accelerator and newly developed separation and detection ...

  16. Synthetic biology of antimicrobial discovery.

    Science.gov (United States)

    Zakeri, Bijan; Lu, Timothy K

    2013-07-19

    Antibiotic discovery has a storied history. From the discovery of penicillin by Sir Alexander Fleming to the relentless quest for antibiotics by Selman Waksman, the stories have become like folklore used to inspire future generations of scientists. However, recent discovery pipelines have run dry at a time when multidrug-resistant pathogens are on the rise. Nature has proven to be a valuable reservoir of antimicrobial agents, which are primarily produced by modularized biochemical pathways. Such modularization is well suited to remodeling by an interdisciplinary approach that spans science and engineering. Herein, we discuss the biological engineering of small molecules, peptides, and non-traditional antimicrobials and provide an overview of the growing applicability of synthetic biology to antimicrobials discovery.

  17. The discovery of 'heavy light'

    International Nuclear Information System (INIS)

    Anon.

    1983-01-01

    The history of the discoveries of fundamental quanta is described starting from Maxwell's theory of electromagnetism up to the development of a theory of weak interaction and the detection of the W and Z bosons. (HSI).

  18. Discovery – Development of Rituximab

    Science.gov (United States)

    NCI funded the development of rituximab, one of the first monoclonal antibody cancer treatments. With the discovery of rituximab, more than 70 percent of patients diagnosed with non-hodgkin lymphoma now live five years past their initial diagnosis.

  19. Radioactivity. Centenary of radioactivity discovery

    International Nuclear Information System (INIS)

    Charpak, G.; Tubiana, M.; Bimbot, R.

    1997-01-01

    This small booklet was edited for the occasion of the exhibitions of the celebration of the centenary of radioactivity discovery which took place in various locations in France from 1996 to 1998. It recalls some basic knowledge concerning radioactivity and its applications: history of discovery, atoms and isotopes, radiations, measurement of ionizing radiations, natural and artificial radioactivity, isotope dating and labelling, radiotherapy, nuclear power and reactors, fission and fusion, nuclear wastes, dosimetry, effects and radioprotection. (J.S.)

  20. Computational methods in drug discovery

    Directory of Open Access Journals (Sweden)

    Sumudu P. Leelananda

    2016-12-01

    Full Text Available The process for drug discovery and development is challenging, time consuming and expensive. Computer-aided drug discovery (CADD tools can act as a virtual shortcut, assisting in the expedition of this long process and potentially reducing the cost of research and development. Today CADD has become an effective and indispensable tool in therapeutic development. The human genome project has made available a substantial amount of sequence data that can be used in various drug discovery projects. Additionally, increasing knowledge of biological structures, as well as increasing computer power have made it possible to use computational methods effectively in various phases of the drug discovery and development pipeline. The importance of in silico tools is greater than ever before and has advanced pharmaceutical research. Here we present an overview of computational methods used in different facets of drug discovery and highlight some of the recent successes. In this review, both structure-based and ligand-based drug discovery methods are discussed. Advances in virtual high-throughput screening, protein structure prediction methods, protein–ligand docking, pharmacophore modeling and QSAR techniques are reviewed.

  1. Get Involved in Planetary Discoveries through New Worlds, New Discoveries

    Science.gov (United States)

    Shupla, Christine; Shipp, S. S.; Halligan, E.; Dalton, H.; Boonstra, D.; Buxner, S.; SMD Planetary Forum, NASA

    2013-01-01

    "New Worlds, New Discoveries" is a synthesis of NASA’s 50-year exploration history which provides an integrated picture of our new understanding of our solar system. As NASA spacecraft head to and arrive at key locations in our solar system, "New Worlds, New Discoveries" provides an integrated picture of our new understanding of the solar system to educators and the general public! The site combines the amazing discoveries of past NASA planetary missions with the most recent findings of ongoing missions, and connects them to the related planetary science topics. "New Worlds, New Discoveries," which includes the "Year of the Solar System" and the ongoing celebration of the "50 Years of Exploration," includes 20 topics that share thematic solar system educational resources and activities, tied to the national science standards. This online site and ongoing event offers numerous opportunities for the science community - including researchers and education and public outreach professionals - to raise awareness, build excitement, and make connections with educators, students, and the public about planetary science. Visitors to the site will find valuable hands-on science activities, resources and educational materials, as well as the latest news, to engage audiences in planetary science topics and their related mission discoveries. The topics are tied to the big questions of planetary science: how did the Sun’s family of planets and bodies originate and how have they evolved? How did life begin and evolve on Earth, and has it evolved elsewhere in our solar system? Scientists and educators are encouraged to get involved either directly or by sharing "New Worlds, New Discoveries" and its resources with educators, by conducting presentations and events, sharing their resources and events to add to the site, and adding their own public events to the site’s event calendar! Visit to find quality resources and ideas. Connect with educators, students and the public to

  2. 42 CFR 426.432 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Discovery. 426.432 Section 426.432 Public Health... § 426.432 Discovery. (a) General rule. If the ALJ orders discovery, the ALJ must establish a reasonable timeframe for discovery. (b) Protective order—(1) Request for a protective order. Any party receiving a...

  3. 40 CFR 27.21 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Discovery. 27.21 Section 27.21... Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for..., discovery is available only as ordered by the presiding officer. The presiding officer shall regulate the...

  4. 13 CFR 134.213 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Discovery. 134.213 Section 134.213... OFFICE OF HEARINGS AND APPEALS Rules of Practice for Most Cases § 134.213 Discovery. (a) Motion. A party may obtain discovery only upon motion, and for good cause shown. (b) Forms. The forms of discovery...

  5. 37 CFR 41.150 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Discovery. 41.150 Section 41... COMMERCE PRACTICE BEFORE THE BOARD OF PATENT APPEALS AND INTERFERENCES Contested Cases § 41.150 Discovery. (a) Limited discovery. A party is not entitled to discovery except as authorized in this subpart. The...

  6. 19 CFR 354.10 - Discovery.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Discovery. 354.10 Section 354.10 Customs Duties... ANTIDUMPING OR COUNTERVAILING DUTY ADMINISTRATIVE PROTECTIVE ORDER § 354.10 Discovery. (a) Voluntary discovery. All parties are encouraged to engage in voluntary discovery procedures regarding any matter, not...

  7. 14 CFR 13.220 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Discovery. 13.220 Section 13.220... INVESTIGATIVE AND ENFORCEMENT PROCEDURES Rules of Practice in FAA Civil Penalty Actions § 13.220 Discovery. (a) Initiation of discovery. Any party may initiate discovery described in this section, without the consent or...

  8. 49 CFR 604.38 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Discovery. 604.38 Section 604.38 Transportation... TRANSPORTATION CHARTER SERVICE Hearings. § 604.38 Discovery. (a) Permissible forms of discovery shall be within the discretion of the PO. (b) The PO shall limit the frequency and extent of discovery permitted by...

  9. 15 CFR 719.10 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Discovery. 719.10 Section 719.10... Discovery. (a) General. The parties are encouraged to engage in voluntary discovery regarding any matter... the Federal Rules of Civil Procedure relating to discovery apply to the extent consistent with this...

  10. 14 CFR 16.213 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Discovery. 16.213 Section 16.213... PRACTICE FOR FEDERALLY-ASSISTED AIRPORT ENFORCEMENT PROCEEDINGS Hearings § 16.213 Discovery. (a) Discovery... discovery permitted by this section if a party shows that— (1) The information requested is cumulative or...

  11. 28 CFR 76.21 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Discovery. 76.21 Section 76.21 Judicial... POSSESSION OF CERTAIN CONTROLLED SUBSTANCES § 76.21 Discovery. (a) Scope. Discovery under this part covers... as a general guide for discovery practices in proceedings before the Judge. However, unless otherwise...

  12. 36 CFR 1150.63 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Discovery. 1150.63 Section... PRACTICE AND PROCEDURES FOR COMPLIANCE HEARINGS Prehearing Conferences and Discovery § 1150.63 Discovery. (a) Parties are encouraged to engage in voluntary discovery procedures. For good cause shown under...

  13. 10 CFR 13.21 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Discovery. 13.21 Section 13.21 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.21 Discovery. (a) The following types of discovery are...) Unless mutually agreed to by the parties, discovery is available only as ordered by the ALJ. The ALJ...

  14. 49 CFR 1121.2 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Discovery. 1121.2 Section 1121.2 Transportation... TRANSPORTATION RULES OF PRACTICE RAIL EXEMPTION PROCEDURES § 1121.2 Discovery. Discovery shall follow the procedures set forth at 49 CFR part 1114, subpart B. Discovery may begin upon the filing of the petition for...

  15. 24 CFR 26.18 - Discovery.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Discovery. 26.18 Section 26.18... PROCEDURES Hearings Before Hearing Officers Discovery § 26.18 Discovery. (a) General. The parties are encouraged to engage in voluntary discovery procedures, which may commence at any time after an answer has...

  16. 38 CFR 42.21 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Discovery. 42.21 Section... IMPLEMENTING THE PROGRAM FRAUD CIVIL REMEDIES ACT § 42.21 Discovery. (a) The following types of discovery are... creation of a document. (c) Unless mutually agreed to by the parties, discovery is available only as...

  17. 22 CFR 521.21 - Discovery.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Discovery. 521.21 Section 521.21 Foreign... Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for... interpreted to require the creation of a document. (c) Unless mutually agreed to by the parties, discovery is...

  18. 31 CFR 10.71 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Discovery. 10.71 Section 10.71 Money... SERVICE Rules Applicable to Disciplinary Proceedings § 10.71 Discovery. (a) In general. Discovery may be... relevance, materiality and reasonableness of the requested discovery and subject to the requirements of § 10...

  19. 42 CFR 426.532 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Discovery. 426.532 Section 426.532 Public Health... § 426.532 Discovery. (a) General rule. If the Board orders discovery, the Board must establish a reasonable timeframe for discovery. (b) Protective order—(1) Request for a protective order. Any party...

  20. 39 CFR 955.15 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Discovery. 955.15 Section 955.15 Postal Service... APPEALS § 955.15 Discovery. (a) The parties are encouraged to engage in voluntary discovery procedures. In connection with any deposition or other discovery procedure, the Board may issue any order which justice...

  1. 49 CFR 1503.633 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Discovery. 1503.633 Section 1503.633... Rules of Practice in TSA Civil Penalty Actions § 1503.633 Discovery. (a) Initiation of discovery. Any party may initiate discovery described in this section, without the consent or approval of the ALJ, at...

  2. 43 CFR 35.21 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Discovery. 35.21 Section 35.21 Public... AND STATEMENTS § 35.21 Discovery. (a) The following types of discovery are authorized: (1) Requests...) Unless mutually agreed to by the parties, discovery is available only as ordered by the ALJ. The ALJ...

  3. 14 CFR 1264.120 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Discovery. 1264.120 Section 1264.120... PENALTIES ACT OF 1986 § 1264.120 Discovery. (a) The following types of discovery are authorized: (1..., discovery is available only as ordered by the presiding officer. The presiding officer shall regulate the...

  4. 22 CFR 128.6 - Discovery.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Discovery. 128.6 Section 128.6 Foreign... Discovery. (a) Discovery by the respondent. The respondent, through the Administrative Law Judge, may... discovery if the interests of national security or foreign policy so require, or if necessary to comply with...

  5. 37 CFR 11.52 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Discovery. 11.52 Section 11... Disciplinary Proceedings; Jurisdiction, Sanctions, Investigations, and Proceedings § 11.52 Discovery. Discovery... establishes that discovery is reasonable and relevant, the hearing officer, under such conditions as he or she...

  6. 24 CFR 26.42 - Discovery.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Discovery. 26.42 Section 26.42... PROCEDURES Hearings Pursuant to the Administrative Procedure Act Discovery § 26.42 Discovery. (a) General. The parties are encouraged to engage in voluntary discovery procedures, which may commence at any time...

  7. 49 CFR 386.37 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Discovery. 386.37 Section 386.37 Transportation... and Hearings § 386.37 Discovery. (a) Parties may obtain discovery by one or more of the following...; and requests for admission. (b) Discovery may not commence until the matter is pending before the...

  8. 29 CFR 1955.32 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Discovery. 1955.32 Section 1955.32 Labor Regulations...) PROCEDURES FOR WITHDRAWAL OF APPROVAL OF STATE PLANS Preliminary Conference and Discovery § 1955.32 Discovery... allow discovery by any other appropriate procedure, such as by interrogatories upon a party or request...

  9. 31 CFR 16.21 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Discovery. 16.21 Section 16.21 Money... FRAUD CIVIL REMEDIES ACT OF 1986 § 16.21 Discovery. (a) The following types of discovery are authorized... to require the creation of a document. (c) Unless mutually agreed to by the parties, discovery is...

  10. 15 CFR 766.9 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Discovery. 766.9 Section 766.9... PROCEEDINGS § 766.9 Discovery. (a) General. The parties are encouraged to engage in voluntary discovery... provisions of the Federal Rules of Civil Procedure relating to discovery apply to the extent consistent with...

  11. 43 CFR 4.1130 - Discovery methods.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Discovery methods. 4.1130 Section 4.1130... Special Rules Applicable to Surface Coal Mining Hearings and Appeals Discovery § 4.1130 Discovery methods. Parties may obtain discovery by one or more of the following methods— (a) Depositions upon oral...

  12. The Europa Ocean Discovery mission

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, B.C. [Los Alamos National Lab., NM (United States); Chyba, C.F. [Univ. of Arizona, Tucson, AZ (United States); Abshire, J.B. [National Aeronautics and Space Administration, Greenbelt, MD (United States). Goddard Space Flight Center] [and others

    1997-06-01

    Since it was first proposed that tidal heating of Europa by Jupiter might lead to liquid water oceans below Europa`s ice cover, there has been speculation over the possible exobiological implications of such an ocean. Liquid water is the essential ingredient for life as it is known, and the existence of a second water ocean in the Solar System would be of paramount importance for seeking the origin and existence of life beyond Earth. The authors present here a Discovery-class mission concept (Europa Ocean Discovery) to determine the existence of a liquid water ocean on Europa and to characterize Europa`s surface structure. The technical goal of the Europa Ocean Discovery mission is to study Europa with an orbiting spacecraft. This goal is challenging but entirely feasible within the Discovery envelope. There are four key challenges: entering Europan orbit, generating power, surviving long enough in the radiation environment to return valuable science, and complete the mission within the Discovery program`s launch vehicle and budget constraints. The authors will present here a viable mission that meets these challenges.

  13. Deep Learning in Drug Discovery.

    Science.gov (United States)

    Gawehn, Erik; Hiss, Jan A; Schneider, Gisbert

    2016-01-01

    Artificial neural networks had their first heyday in molecular informatics and drug discovery approximately two decades ago. Currently, we are witnessing renewed interest in adapting advanced neural network architectures for pharmaceutical research by borrowing from the field of "deep learning". Compared with some of the other life sciences, their application in drug discovery is still limited. Here, we provide an overview of this emerging field of molecular informatics, present the basic concepts of prominent deep learning methods and offer motivation to explore these techniques for their usefulness in computer-assisted drug discovery and design. We specifically emphasize deep neural networks, restricted Boltzmann machine networks and convolutional networks. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Discovery of the Higgs boson

    CERN Document Server

    Sharma, Vivek

    2016-01-01

    The recent observation of the Higgs boson has been hailed as the scientific discovery of the century and led to the 2013 Nobel Prize in physics. This book describes the detailed science behind the decades-long search for this elusive particle at the Large Electron Positron Collider at CERN and at the Tevatron at Fermilab and its subsequent discovery and characterization at the Large Hadron Collider at CERN. Written by physicists who played leading roles in this epic search and discovery, this book is an authoritative and pedagogical exposition of the portrait of the Higgs boson that has emerged from a large number of experimental measurements. As the first of its kind, this book should be of interest to graduate students and researchers in particle physics.

  15. Bioinformatics in translational drug discovery.

    Science.gov (United States)

    Wooller, Sarah K; Benstead-Hume, Graeme; Chen, Xiangrong; Ali, Yusuf; Pearl, Frances M G

    2017-08-31

    Bioinformatics approaches are becoming ever more essential in translational drug discovery both in academia and within the pharmaceutical industry. Computational exploitation of the increasing volumes of data generated during all phases of drug discovery is enabling key challenges of the process to be addressed. Here, we highlight some of the areas in which bioinformatics resources and methods are being developed to support the drug discovery pipeline. These include the creation of large data warehouses, bioinformatics algorithms to analyse 'big data' that identify novel drug targets and/or biomarkers, programs to assess the tractability of targets, and prediction of repositioning opportunities that use licensed drugs to treat additional indications. © 2017 The Author(s).

  16. The discovery of subatomic particles

    International Nuclear Information System (INIS)

    Weinberg, S.

    1984-01-01

    This book developed from a course for students with no prior training in mathematics of physics to learn about the achievements of 20th century physics and classical physics. It covers the discovery of fundamental particles of ordinary atoms: the electron, the proton, and the neutron. The general outline is historical and it is for readers unfamiliar with classical physics who wish to understand the ideas and experiments that make up the history of 20th century physics. Contents include: A world of particles, the discovery of the electron, the atomic scale, the nucleus, more particles

  17. MUCHO MÁS QUE SÓLO APROVISIONAMIENTO LÍTICO: ACTIVIDADES EN CANTERAS Y PRÁCTICAS SOCIALES EN LAS FUENTES DE PAMPA OESTE, QUEBRADA SECA Y PUNTA DE LA PEÑA (ANTOFAGASTA DE LA SIERRA, CATAMARCA / Much more than just lithic procurement: activities at quarrie

    Directory of Open Access Journals (Sweden)

    Federico Miguel Bobillo

    2015-06-01

    Full Text Available En este trabajo se abordan las canteras y talleres asociados de Punta de la Peña, Quebrada Seca y Pampa Oeste, en Antofagasta de la Sierra (Catamarca, con el objeto de explorar la multiplicidad de actividades y prácticas sociales involucradas en la utilización de dichas fuentes. Se trata de tres fuentes de vulcanitas intensamente explotadas a lo largo de la secuencia prehispánica del área. De esta forma, se toma a las canteras no sólo como un depósito de rocas útiles para la subsistencia, sino como un escenario social donde confluyen y se materializan diferentes prácticas y expresiones sociales. Así, a la explotación de las rocas se suman toda una serie de tareas vinculadas, por ejemplo, con prácticas de enseñanza/aprendizaje y actividades de subsistencia, procesamiento/consumo y rituales. Esta aproximación considera a las canteras desde una perspectiva orientada a abordar las elecciones y prácticas llevadas a cabo por los agentes en contextos de aprovisionamiento, partiendo de la base de que estos actúan desarrollando una diversidad de actividades conectadas en torno a la apropiación de un recurso específico.Abstract  Quarries and workshops at Punta de la Peña, Quebrada Seca and Pampa Oeste (Antofagasta de la Sierra, Catamarca are considered in this paper. The goal is to explore the multiplicity of social activities and practices involved in the use of these quarries. These three vulcanite sources were intensively exploited during the pre-Hispanic history of the region. In this way, quarries are not only considered rock deposits useful for subsistence, but also a social scenario where different social practices and social expressions converge and are materialized. Thereby, series of linked tasks are added to rock exploitation. For example, teaching/learning practices and subsistence, processing/consumption and ritual activities. This approach considers quarries from a perspective oriented to the analysis of elections and

  18. Quarks, history of a discovery

    International Nuclear Information System (INIS)

    Husson, D.

    2000-01-01

    This book gives a presentation of quarks and stresses on the historical aspects of the studies that led to their discovery. The 'aesthetical' motivations of the scientists in their research are explained with only a minimum of mathematical concepts. (J.S.)

  19. On the threshold of discovery

    International Nuclear Information System (INIS)

    Cherenkov, P.A.

    1986-01-01

    The author, the discoverer of the Cherenkov radiation, recalls some interesting circumstances of his discoery 50 years ago and puts it into the context of the knowledge of the period. The discovery of Cherenkov radiation which today is in practice used especially for the detection of charged particles, was correctly understood and appreciated somewhat belatedly. At first the discovery was met with distrust and the original article announcing it was rejected by the magazine Nature. In effect, the discovery was not the result of any planned experiment but was the by-product of another research. It was, of course, allowed by previous achievements in various fields of physics, namely progress reached in the study of luminescence by S.I. Vavilov and his pupils. The discovery was made during an experimental study of luminescence induced in liquids by the β and γ radiations of uranyl salts. During his attempts to suppress the background radiation from vessel walls the autor found a ''background'' from pure solvent which differed from luminescence by being independent of the concentration, temperature and viscosity of the liquid. A closer examination of the phenomenon more or less by accident revealed its marked spatial asymmetry which had major importance for the development of the theory of the new phenomenon by I.V. Tamm and I.M. Frank. (A.K.)

  20. DISCOVERY IN THE URBAN SPRAWL.

    Science.gov (United States)

    HYMOVITZ, LEON

    FOR A CULTURAL ENRICHMENT PROJECT ("DISCOVERY") IN A DISADVANTAGED PHILADELPIA HIGH SCHOOL, ATTENDANCE AT MUSIC, ART, AND THEATER EVENTS EARNED POINTS TOWARD A CERTIFICATE. THE STUDENTS ELECTED THE EVENTS FROM A PREPARED LIST OF ACTIVITIES, WHICH OFTEN WERE MADE PART OF THE ACADEMIC PROGRAM AND THE SCHOOL ASSEMBLIES. AS WELL AS OFFERING…

  1. Hubble 15 years of discovery

    CERN Document Server

    Lindberg Christensen, Lars; Kornmesser, M

    2006-01-01

    Hubble: 15 Years of Discovery was a key element of the European Space Agency's 15th anniversary celebration activities for the 1990 launch of the NASA/ESA Hubble Space Telescope. As an observatory in space, Hubble is one of the most successful scientific projects of all time, both in terms of scientific output and its immediate public appeal.

  2. Applied metabolomics in drug discovery.

    Science.gov (United States)

    Cuperlovic-Culf, M; Culf, A S

    2016-08-01

    The metabolic profile is a direct signature of phenotype and biochemical activity following any perturbation. Metabolites are small molecules present in a biological system including natural products as well as drugs and their metabolism by-products depending on the biological system studied. Metabolomics can provide activity information about possible novel drugs and drug scaffolds, indicate interesting targets for drug development and suggest binding partners of compounds. Furthermore, metabolomics can be used for the discovery of novel natural products and in drug development. Metabolomics can enhance the discovery and testing of new drugs and provide insight into the on- and off-target effects of drugs. This review focuses primarily on the application of metabolomics in the discovery of active drugs from natural products and the analysis of chemical libraries and the computational analysis of metabolic networks. Metabolomics methodology, both experimental and analytical is fast developing. At the same time, databases of compounds are ever growing with the inclusion of more molecular and spectral information. An increasing number of systems are being represented by very detailed metabolic network models. Combining these experimental and computational tools with high throughput drug testing and drug discovery techniques can provide new promising compounds and leads.

  3. Nobel Prize Honors Autophagy Discovery.

    Science.gov (United States)

    2016-12-01

    Japanese cell biologist Yoshinori Ohsumi, PhD, was awarded this year's Nobel Prize in Physiology or Medicine for his discovery of autophagy. His groundbreaking studies in yeast cells illuminated how cells break down and recycle damaged material, a process that is critical to the survival of both normal cells and some cancer cells. ©2016 American Association for Cancer Research.

  4. Translational medicine and drug discovery

    National Research Council Canada - National Science Library

    Littman, Bruce H; Krishna, Rajesh

    2011-01-01

    ..., and examples of their application to real-life drug discovery and development. The latest thinking is presented by researchers from many of the world's leading pharmaceutical companies, including Pfizer, Merck, Eli Lilly, Abbott, and Novartis, as well as from academic institutions and public- private partnerships that support translational research...

  5. New oil and gas discoveries

    International Nuclear Information System (INIS)

    Alazard-Toux, N.

    2004-01-01

    During the period 1999-2003, new oil and gas fields generated additional reserves of nearly 11 000 bcm of natural gas and 62 Gbbl of oil and condensates, volumes very much superior to those discovered in the five previous years. Two-thirds of these discoveries were located offshore, half in deep water. (author)

  6. Maximum Entropy in Drug Discovery

    Directory of Open Access Journals (Sweden)

    Chih-Yuan Tseng

    2014-07-01

    Full Text Available Drug discovery applies multidisciplinary approaches either experimentally, computationally or both ways to identify lead compounds to treat various diseases. While conventional approaches have yielded many US Food and Drug Administration (FDA-approved drugs, researchers continue investigating and designing better approaches to increase the success rate in the discovery process. In this article, we provide an overview of the current strategies and point out where and how the method of maximum entropy has been introduced in this area. The maximum entropy principle has its root in thermodynamics, yet since Jaynes’ pioneering work in the 1950s, the maximum entropy principle has not only been used as a physics law, but also as a reasoning tool that allows us to process information in hand with the least bias. Its applicability in various disciplines has been abundantly demonstrated. We give several examples of applications of maximum entropy in different stages of drug discovery. Finally, we discuss a promising new direction in drug discovery that is likely to hinge on the ways of utilizing maximum entropy.

  7. Structural Biology Guides Antibiotic Discovery

    Science.gov (United States)

    Polyak, Steven

    2014-01-01

    Modern drug discovery programs require the contribution of researchers in a number of specialist areas. One of these areas is structural biology. Using X-ray crystallography, the molecular basis of how a drug binds to its biological target and exerts its mode of action can be defined. For example, a drug that binds into the active site of an…

  8. Quantifying the Ease of Scientific Discovery.

    Science.gov (United States)

    Arbesman, Samuel

    2011-02-01

    It has long been known that scientific output proceeds on an exponential increase, or more properly, a logistic growth curve. The interplay between effort and discovery is clear, and the nature of the functional form has been thought to be due to many changes in the scientific process over time. Here I show a quantitative method for examining the ease of scientific progress, another necessary component in understanding scientific discovery. Using examples from three different scientific disciplines - mammalian species, chemical elements, and minor planets - I find the ease of discovery to conform to an exponential decay. In addition, I show how the pace of scientific discovery can be best understood as the outcome of both scientific output and ease of discovery. A quantitative study of the ease of scientific discovery in the aggregate, such as done here, has the potential to provide a great deal of insight into both the nature of future discoveries and the technical processes behind discoveries in science.

  9. Arthritis Genetics Analysis Aids Drug Discovery

    Science.gov (United States)

    ... NIH Research Matters January 13, 2014 Arthritis Genetics Analysis Aids Drug Discovery An international research team identified 42 new ... Edition Distracted Driving Raises Crash Risk Arthritis Genetics Analysis Aids Drug Discovery Oxytocin Affects Facial Recognition Connect with Us ...

  10. Bioinformatics for cancer immunotherapy target discovery

    DEFF Research Database (Denmark)

    Olsen, Lars Rønn; Campos, Benito; Barnkob, Mike Stein

    2014-01-01

    therapy target discovery in a bioinformatics analysis pipeline. We describe specialized bioinformatics tools and databases for three main bottlenecks in immunotherapy target discovery: the cataloging of potentially antigenic proteins, the identification of potential HLA binders, and the selection epitopes...

  11. The circumstances of minor planet discovery

    International Nuclear Information System (INIS)

    Pilcher, F.

    1989-01-01

    The circumstances of discoveries of minor planets are presented in tabular form. Complete data are given for planets 2125-4044, together with notes pertaining to these planets. Information in the table includes the permanent number; the official name; for planets 330 and forward, the table includes the provisional designation attached to the discovery apparition and the year, month, the day of discovery, and the discovery place

  12. 15 CFR 280.210 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Discovery. 280.210 Section 280.210... STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE ACCREDITATION AND ASSESSMENT PROGRAMS FASTENER QUALITY Enforcement § 280.210 Discovery. (a) General. The parties are encouraged to engage in voluntary discovery...

  13. 6 CFR 13.21 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Discovery. 13.21 Section 13.21 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.21 Discovery. (a) In general. (1) The following types of discovery are authorized: (i) Requests for production of...

  14. 42 CFR 1005.7 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Discovery. 1005.7 Section 1005.7 Public Health... OF EXCLUSIONS, CIVIL MONEY PENALTIES AND ASSESSMENTS § 1005.7 Discovery. (a) A party may make a... and any forms of discovery, other than those permitted under paragraph (a) of this section, are not...

  15. 42 CFR 405.1037 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Discovery. 405.1037 Section 405.1037 Public Health... Appeals Under Original Medicare (Part A and Part B) Alj Hearings § 405.1037 Discovery. (a) General rules. (1) Discovery is permissible only when CMS or its contractor elects to participate in an ALJ hearing...

  16. 45 CFR 99.23 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Discovery. 99.23 Section 99.23 Public Welfare... DEVELOPMENT FUND Hearing Procedures § 99.23 Discovery. The Department, the Lead Agency, and any individuals or groups recognized as parties shall have the right to conduct discovery (including depositions) against...

  17. 29 CFR 1603.210 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Discovery. 1603.210 Section 1603.210 Labor Regulations... GOVERNMENT EMPLOYEE RIGHTS ACT OF 1991 Hearings § 1603.210 Discovery. (a) Unless otherwise ordered by the administrative law judge, discovery may begin as soon as the complaint has been transmitted to the administrative...

  18. 41 CFR 60-30.33 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Discovery. 60-30.33... 11246 Expedited Hearing Procedures § 60-30.33 Discovery. (a) Any party may serve requests for admissions... with § 60-30.8, the Administrative Law Judge may allow the taking of depositions. Other discovery will...

  19. 45 CFR 150.435 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Discovery. 150.435 Section 150.435 Public Welfare... AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.435 Discovery. (a) The parties must identify any need for discovery from the opposing party as soon as possible, but no later than the time for...

  20. 10 CFR 1013.21 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Discovery. 1013.21 Section 1013.21 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) PROGRAM FRAUD CIVIL REMEDIES AND PROCEDURES § 1013.21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for inspection and...

  1. 20 CFR 355.21 - Discovery.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Discovery. 355.21 Section 355.21 Employees... UNDER THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 355.21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for inspection and copying; (2) Requests...

  2. 34 CFR 81.16 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Discovery. 81.16 Section 81.16 Education Office of the... Discovery. (a) The parties to a case are encouraged to exchange relevant documents and information voluntarily. (b) The ALJ, at a party's request, may order compulsory discovery described in paragraph (c) of...

  3. 10 CFR 2.1018 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Discovery. 2.1018 Section 2.1018 Energy NUCLEAR REGULATORY... Geologic Repository § 2.1018 Discovery. (a)(1) Parties, potential parties, and interested governmental participants in the high-level waste licensing proceeding may obtain discovery by one or more of the following...

  4. 45 CFR 213.23a - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Discovery. 213.23a Section 213.23a Public Welfare... Discovery. The Department and any party named in the notice issued pursuant to § 213.11 shall have the right to conduct discovery (including depositions) against opposing parties. Rules 26-37 of the Federal...

  5. 29 CFR 2200.208 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Discovery. 2200.208 Section 2200.208 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH REVIEW COMMISSION RULES OF PROCEDURE Simplified Proceedings § 2200.208 Discovery. Discovery, including requests for admissions, will only be...

  6. 47 CFR 65.105 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Discovery. 65.105 Section 65.105... OF RETURN PRESCRIPTION PROCEDURES AND METHODOLOGIES Procedures § 65.105 Discovery. (a) Participants... evidence. (c) Discovery requests pursuant to § 65.105(b), including written interrogatories, shall be filed...

  7. 28 CFR 71.21 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Discovery. 71.21 Section 71.21 Judicial... REMEDIES ACT OF 1986 Implementation for Actions Initiated by the Department of Justice § 71.21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for...

  8. 13 CFR 134.310 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Discovery. 134.310 Section 134.310 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING CASES BEFORE THE... Designations § 134.310 Discovery. Discovery will not be permitted in appeals from size determinations or NAICS...

  9. 20 CFR 498.207 - Discovery.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Discovery. 498.207 Section 498.207 Employees... § 498.207 Discovery. (a) For the purpose of inspection and copying, a party may make a request to...) Any form of discovery other than that permitted under paragraph (a) of this section, such as requests...

  10. 29 CFR 1905.25 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 5 2010-07-01 2010-07-01 false Discovery. 1905.25 Section 1905.25 Labor Regulations... OCCUPATIONAL SAFETY AND HEALTH ACT OF 1970 Hearings § 1905.25 Discovery. (a) Depositions. (1) For reasons of... discovery. Whenever appropriate to a just disposition of any issue in a hearing, the presiding hearing...

  11. 34 CFR 33.21 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Discovery. 33.21 Section 33.21 Education Office of the Secretary, Department of Education PROGRAM FRAUD CIVIL REMEDIES ACT § 33.21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for inspection and copying...

  12. 42 CFR 93.512 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Discovery. 93.512 Section 93.512 Public Health... Process § 93.512 Discovery. (a) Request to provide documents. A party may only request another party to...) Responses to a discovery request. Within 30 days of receiving a request for the production of documents, a...

  13. 49 CFR 209.313 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Discovery. 209.313 Section 209.313 Transportation... TRANSPORTATION RAILROAD SAFETY ENFORCEMENT PROCEDURES Disqualification Procedures § 209.313 Discovery. (a... parties. Discovery is designed to enable a party to obtain relevant information needed for preparation of...

  14. 12 CFR 1780.26 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Discovery. 1780.26 Section 1780.26 Banks and... OF PRACTICE AND PROCEDURE RULES OF PRACTICE AND PROCEDURE Prehearing Proceedings § 1780.26 Discovery. (a) Limits on discovery. Subject to the limitations set out in paragraphs (b), (d), and (e) of this...

  15. 37 CFR 2.120 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Discovery. 2.120 Section 2... COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Procedure in Inter Partes Proceedings § 2.120 Discovery. (a... to disclosure and discovery shall apply in opposition, cancellation, interference and concurrent use...

  16. 45 CFR 160.516 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Discovery. 160.516 Section 160.516 Public Welfare... ADMINISTRATIVE REQUIREMENTS Procedures for Hearings § 160.516 Discovery. (a) A party may make a request to... forms of discovery, other than those permitted under paragraph (a) of this section, are not authorized...

  17. 46 CFR 550.502 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 9 2010-10-01 2010-10-01 false Discovery. 550.502 Section 550.502 Shipping FEDERAL... Proceedings § 550.502 Discovery. The Commission may authorize a party to a proceeding to use depositions, written interrogatories, and discovery procedures that, to the extent practicable, are in conformity with...

  18. 28 CFR 18.7 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Discovery. 18.7 Section 18.7 Judicial Administration DEPARTMENT OF JUSTICE OFFICE OF JUSTICE PROGRAMS HEARING AND APPEAL PROCEDURES § 18.7 Discovery.... Such order may be entered upon a showing that the deposition is necessary for discovery purposes, and...

  19. 10 CFR 205.198 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Discovery. 205.198 Section 205.198 Energy DEPARTMENT OF... of Proposed Disallowance, and Order of Disallowance § 205.198 Discovery. (a) If a person intends to file a Motion for Discovery, he must file it at the same time that he files his Statement of Objections...

  20. 42 CFR 3.516 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Discovery. 3.516 Section 3.516 Public Health PUBLIC... AND PATIENT SAFETY WORK PRODUCT Enforcement Program § 3.516 Discovery. (a) A party may make a request... and any forms of discovery, other than those permitted under paragraph (a) of this section, are not...

  1. 12 CFR 908.46 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Discovery. 908.46 Section 908.46 Banks and... PRACTICE AND PROCEDURE IN HEARINGS ON THE RECORD Pre-Hearing Proceedings § 908.46 Discovery. (a) Limits on discovery. Subject to the limitations set out in paragraphs (b), (d), and (e) of this section, any party to...

  2. 15 CFR 785.8 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Discovery. 785.8 Section 785.8... INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL REGULATIONS ENFORCEMENT § 785.8 Discovery. (a) General. The parties are encouraged to engage in voluntary discovery regarding any matter, not...

  3. 22 CFR 35.21 - Discovery.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Discovery. 35.21 Section 35.21 Foreign Relations DEPARTMENT OF STATE CLAIMS AND STOLEN PROPERTY PROGRAM FRAUD CIVIL REMEDIES § 35.21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for...

  4. 29 CFR 22.21 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Discovery. 22.21 Section 22.21 Labor Office of the Secretary of Labor PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 22.21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for inspection and copying; (2) Requests...

  5. 42 CFR 430.86 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Discovery. 430.86 Section 430.86 Public Health... Plans and Practice to Federal Requirements § 430.86 Discovery. CMS and any party named in the notice issued under § 430.70 has the right to conduct discovery (including depositions) against opposing parties...

  6. 21 CFR 17.23 - Discovery.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Discovery. 17.23 Section 17.23 Food and Drugs FOOD... HEARINGS § 17.23 Discovery. (a) No later than 60 days prior to the hearing, unless otherwise ordered by the..., depositions, and any forms of discovery, other than those permitted under paragraphs (a) and (e) of this...

  7. 45 CFR 96.65 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Discovery. 96.65 Section 96.65 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION BLOCK GRANTS Hearing Procedure § 96.65 Discovery. The use of interrogatories, depositions, and other forms of discovery shall not be allowed. ...

  8. 7 CFR 1.322 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Discovery. 1.322 Section 1.322 Agriculture Office of... Under the Program Fraud Civil Remedies Act of 1986 § 1.322 Discovery. (a) The following types of discovery are authorized: (1) Requests for production, inspection and photocopying of documents; (2...

  9. 45 CFR 1386.103 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Discovery. 1386.103 Section 1386.103 Public... Hearing Procedures § 1386.103 Discovery. The Department and any party named in the Notice issued pursuant to § 1386.90 has the right to conduct discovery (including depositions) against opposing parties as...

  10. 45 CFR 79.21 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Discovery. 79.21 Section 79.21 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROGRAM FRAUD CIVIL REMEDIES § 79.21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for...

  11. 49 CFR 31.21 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Discovery. 31.21 Section 31.21 Transportation Office of the Secretary of Transportation PROGRAM FRAUD CIVIL REMEDIES § 31.21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for inspection and...

  12. 12 CFR 308.520 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Discovery. 308.520 Section 308.520 Banks and... PROCEDURE Program Fraud Civil Remedies and Procedures § 308.520 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for inspection and copying; (2) Requests...

  13. 47 CFR 1.729 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Discovery. 1.729 Section 1.729..., and Reports Involving Common Carriers Formal Complaints § 1.729 Discovery. (a) Subject to paragraph (i... seek discovery of any non-privileged matter that is relevant to the material facts in dispute in the...

  14. 7 CFR 283.12 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Discovery. 283.12 Section 283.12 Agriculture... of $50,000 or More § 283.12 Discovery. (a) Dispositions—(1) Motion for taking deposition. Only upon a... exist if the information sought appears reasonably calculated to lead to the discovery of admissible...

  15. Discovery of inhibitors of bacterial histidine kinases

    NARCIS (Netherlands)

    Velikova, N.R.

    2014-01-01

    Discovery of Inhibitors of Bacterial Histidine Kinases Summary

    The thesis is on novel antibacterial drug discovery (http://youtu.be/NRMWOGgeysM). Using structure-based and fragment-based drug discovery approach, we have identified small-molecule histidine-kinase

  16. 29 CFR 18.13 - Discovery methods.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Discovery methods. 18.13 Section 18.13 Labor Office of the... ADMINISTRATIVE LAW JUDGES General § 18.13 Discovery methods. Parties may obtain discovery by one or more of the following methods: Depositions upon oral examination or written questions; written interrogatories...

  17. Glycoscience aids in biomarker discovery

    Directory of Open Access Journals (Sweden)

    Serenus Hua1,2 & Hyun Joo An1,2,*

    2012-06-01

    Full Text Available The glycome consists of all glycans (or carbohydrates within abiological system, and modulates a wide range of important biologicalactivities, from protein folding to cellular communications.The mining of the glycome for disease markers representsa new paradigm for biomarker discovery; however, this effortis severely complicated by the vast complexity and structuraldiversity of glycans. This review summarizes recent developmentsin analytical technology and methodology as applied tothe fields of glycomics and glycoproteomics. Mass spectrometricstrategies for glycan compositional profiling are described, as arepotential refinements which allow structure-specific profiling.Analytical methods that can discern protein glycosylation at aspecific site of modification are also discussed in detail.Biomarker discovery applications are shown at each level ofanalysis, highlighting the key role that glycoscience can play inhelping scientists understand disease biology.

  18. Cyber-Enabled Scientific Discovery

    International Nuclear Information System (INIS)

    Chan, Tony; Jameson, Leland

    2007-01-01

    It is often said that numerical simulation is third in the group of three ways to explore modern science: theory, experiment and simulation. Carefully executed modern numerical simulations can, however, be considered at least as relevant as experiment and theory. In comparison to physical experimentation, with numerical simulation one has the numerically simulated values of every field variable at every grid point in space and time. In comparison to theory, with numerical simulation one can explore sets of very complex non-linear equations such as the Einstein equations that are very difficult to investigate theoretically. Cyber-enabled scientific discovery is not just about numerical simulation but about every possible issue related to scientific discovery by utilizing cyberinfrastructure such as the analysis and storage of large data sets, the creation of tools that can be used by broad classes of researchers and, above all, the education and training of a cyber-literate workforce

  19. Astrobiology, discovery, and societal impact

    CERN Document Server

    Dick, Steven J

    2018-01-01

    The search for life in the universe, once the stuff of science fiction, is now a robust worldwide research program with a well-defined roadmap probing both scientific and societal issues. This volume examines the humanistic aspects of astrobiology, systematically discussing the approaches, critical issues, and implications of discovering life beyond Earth. What do the concepts of life and intelligence, culture and civilization, technology and communication mean in a cosmic context? What are the theological and philosophical implications if we find life - and if we do not? Steven J. Dick argues that given recent scientific findings, the discovery of life in some form beyond Earth is likely and so we need to study the possible impacts of such a discovery and formulate policies to deal with them. The remarkable and often surprising results are presented here in a form accessible to disciplines across the sciences, social sciences, and humanities.

  20. [Artificial Intelligence in Drug Discovery].

    Science.gov (United States)

    Fujiwara, Takeshi; Kamada, Mayumi; Okuno, Yasushi

    2018-04-01

    According to the increase of data generated from analytical instruments, application of artificial intelligence(AI)technology in medical field is indispensable. In particular, practical application of AI technology is strongly required in "genomic medicine" and "genomic drug discovery" that conduct medical practice and novel drug development based on individual genomic information. In our laboratory, we have been developing a database to integrate genome data and clinical information obtained by clinical genome analysis and a computational support system for clinical interpretation of variants using AI. In addition, with the aim of creating new therapeutic targets in genomic drug discovery, we have been also working on the development of a binding affinity prediction system for mutated proteins and drugs by molecular dynamics simulation using supercomputer "Kei". We also have tackled for problems in a drug virtual screening. Our developed AI technology has successfully generated virtual compound library, and deep learning method has enabled us to predict interaction between compound and target protein.

  1. A quantum causal discovery algorithm

    Science.gov (United States)

    Giarmatzi, Christina; Costa, Fabio

    2018-03-01

    Finding a causal model for a set of classical variables is now a well-established task—but what about the quantum equivalent? Even the notion of a quantum causal model is controversial. Here, we present a causal discovery algorithm for quantum systems. The input to the algorithm is a process matrix describing correlations between quantum events. Its output consists of different levels of information about the underlying causal model. Our algorithm determines whether the process is causally ordered by grouping the events into causally ordered non-signaling sets. It detects if all relevant common causes are included in the process, which we label Markovian, or alternatively if some causal relations are mediated through some external memory. For a Markovian process, it outputs a causal model, namely the causal relations and the corresponding mechanisms, represented as quantum states and channels. Our algorithm opens the route to more general quantum causal discovery methods.

  2. Discovery of Approximate Differential Dependencies

    OpenAIRE

    Liu, Jixue; Kwashie, Selasi; Li, Jiuyong; Ye, Feiyue; Vincent, Millist

    2013-01-01

    Differential dependencies (DDs) capture the relationships between data columns of relations. They are more general than functional dependencies (FDs) and and the difference is that DDs are defined on the distances between values of two tuples, not directly on the values. Because of this difference, the algorithms for discovering FDs from data find only special DDs, not all DDs and therefore are not applicable to DD discovery. In this paper, we propose an algorithm to discover DDs from data fo...

  3. The discovery of the antiproton

    International Nuclear Information System (INIS)

    Chamberlain, Owen

    1989-01-01

    A number of groups of particle physicists competed to provide track evidence of the existence of Dirac's postulated antiproton in the mid-1950s. The work of the several teams is described briefly. The author describes the work of his own group on the Bevatron in more detail, and how they finally observed the antiproton. The article finishes with an assessment of the importance of this discovery. (UK)

  4. Gas reserves, discoveries and production

    International Nuclear Information System (INIS)

    Saniere, A.

    2006-01-01

    Between 2000 and 2004, new discoveries, located mostly in the Asia/Pacific region, permitted a 71% produced reserve replacement rate. The Middle East and the offshore sector represent a growing proportion of world gas production Non-conventional gas resources are substantial but are not exploited to any significant extent, except in the United States, where they account for 30% of U.S. gas production. (author)

  5. Sea Level Rise Data Discovery

    Science.gov (United States)

    Quach, N.; Huang, T.; Boening, C.; Gill, K. M.

    2016-12-01

    Research related to sea level rise crosses multiple disciplines from sea ice to land hydrology. The NASA Sea Level Change Portal (SLCP) is a one-stop source for current sea level change information and data, including interactive tools for accessing and viewing regional data, a virtual dashboard of sea level indicators, and ongoing updates through a suite of editorial products that include content articles, graphics, videos, and animations. The architecture behind the SLCP makes it possible to integrate web content and data relevant to sea level change that are archived across various data centers as well as new data generated by sea level change principal investigators. The Extensible Data Gateway Environment (EDGE) is incorporated into the SLCP architecture to provide a unified platform for web content and science data discovery. EDGE is a data integration platform designed to facilitate high-performance geospatial data discovery and access with the ability to support multi-metadata standard specifications. EDGE has the capability to retrieve data from one or more sources and package the resulting sets into a single response to the requestor. With this unified endpoint, the Data Analysis Tool that is available on the SLCP can retrieve dataset and granule level metadata as well as perform geospatial search on the data. This talk focuses on the architecture that makes it possible to seamlessly integrate and enable discovery of disparate data relevant to sea level rise.

  6. A New Universe of Discoveries

    Science.gov (United States)

    Córdova, France A.

    2016-01-01

    The convergence of emerging advances in astronomical instruments, computational capabilities and talented practitioners (both professional and civilian) is creating an extraordinary new environment for making numerous fundamental discoveries in astronomy, ranging from the nature of exoplanets to understanding the evolution of solar systems and galaxies. The National Science Foundation is playing a critical role in supporting, stimulating, and shaping these advances. NSF is more than an agency of government or a funding mechanism for the infrastructure of science. The work of NSF is a sacred trust that every generation of Americans makes to those of the next generation, that we will build on the body of knowledge we inherit and continue to push forward the frontiers of science. We never lose sight of NSF's obligation to "explore the unexplored" and inspire all of humanity with the wonders of discovery. As the only Federal agency dedicated to the support of basic research and education in all fields of science and engineering, NSF has empowered discoveries across a broad spectrum of scientific inquiry for more than six decades. The result is fundamental scientific research that has had a profound impact on our nation's innovation ecosystem and kept our nation at the very forefront of the world's science-and-engineering enterprise.

  7. Discovery of a Makemakean Moon

    Science.gov (United States)

    Parker, Alex H.; Buie, Marc W.; Grundy, Will M.; Noll, Keith S.

    2016-01-01

    We describe the discovery of a satellite in orbit about the dwarf planet (136472) Makemake. This satellite, provisionally designated S/2015 (136472) 1, was detected in imaging data collected with the Hubble Space Telescope's Wide Field Camera 3 on UTC 2015 April 27 at 7.80 +/- 0.04 mag fainter than Makemake and at a separation of 0farcs57. It likely evaded detection in previous satellite searches due to a nearly edge-on orbital configuration, placing it deep within the glare of Makemake during a substantial fraction of its orbital period. This configuration would place Makemake and its satellite near a mutual event season. Insufficient orbital motion was detected to make a detailed characterization of its orbital properties, prohibiting a measurement of the system mass with the discovery data alone. Preliminary analysis indicates that if the orbit is circular, its orbital period must be longer than 12.4 days and must have a semimajor axis > or approx. = 21,000 km. We find that the properties of Makemake's moon suggest that the majority of the dark material detected in the system by thermal observations may not reside on the surface of Makemake, but may instead be attributable to S/2015 (136472) 1 having a uniform dark surface. This dark moon hypothesis can be directly tested with future James Webb Space Telescope observations. We discuss the implications of this discovery for the spin state, figure, and thermal properties of Makemake and the apparent ubiquity of trans-Neptunian dwarf planet satellites.

  8. Socratic Questioning-Guided Discovery

    Directory of Open Access Journals (Sweden)

    M. Hakan Türkçapar

    2012-04-01

    Full Text Available “Socratic Method” is a way of teaching philosophical thinking and knowledge by asking questions which was used by antique period greek philosopher Socrates. Socrates was teaching knowledge to his followers by asking questions and the conversation between them was named “Socratic Dialogues”. In this meaning, no novel knowledge is taught to the individual but only what is formerly known is reminded and rediscovered. The form of socratic questioning which is used during the process of cognitive behavioral therapy is known as Guided Discovery. In this method it is aimed to make the client notice the piece of knowledge which he could notice but is not aware with a series of questions. Socratic method or guided discovery consists of several steps which are: Identifying the problem by listening to the client and making reflections, finding alternatives by examining and evaluating, reidentification by using the newly found information and questioning the old distorted belief and reaching to a conclusion and applying it. Question types used during these procedures are, questions for gaining information, questions revealing the meanings, questions revealing the beliefs, questions about behaviours during the similar past experiences, analyse questions and analytic synthesis questions. In order to make the patient feel understood it is important to be empathetic and summarising the problem during the interview. In this text, steps of Socratic Questioning-Guided Discovery will be reviewed with sample dialogues after eachstep. [JCBPR 2012; 1(1.000: 15-20

  9. DISCOVERY OF A MAKEMAKEAN MOON

    Energy Technology Data Exchange (ETDEWEB)

    Parker, Alex H.; Buie, Marc W. [Southwest Research Institute, 1050 Walnut Street, Suite 300, Boulder, CO 80302 (United States); Grundy, Will M. [Lowell Observatory, Flagstaff, AZ (United States); Noll, Keith S., E-mail: aparker@boulder.swri.edu [NASA Goddard Space Flight Center, Greenbelt, MD (United States)

    2016-07-01

    We describe the discovery of a satellite in orbit about the dwarf planet (136472) Makemake. This satellite, provisionally designated S/2015 (136472) 1, was detected in imaging data collected with the Hubble Space Telescope ’s Wide Field Camera 3 on UTC 2015 April 27 at 7.80 ± 0.04 mag fainter than Makemake and at a separation of 0.″57. It likely evaded detection in previous satellite searches due to a nearly edge-on orbital configuration, placing it deep within the glare of Makemake during a substantial fraction of its orbital period. This configuration would place Makemake and its satellite near a mutual event season. Insufficient orbital motion was detected to make a detailed characterization of its orbital properties, prohibiting a measurement of the system mass with the discovery data alone. Preliminary analysis indicates that if the orbit is circular, its orbital period must be longer than 12.4 days and must have a semimajor axis ≳21,000 km. We find that the properties of Makemake’s moon suggest that the majority of the dark material detected in the system by thermal observations may not reside on the surface of Makemake, but may instead be attributable to S/2015 (136472) 1 having a uniform dark surface. This “dark moon hypothesis” can be directly tested with future James Webb Space Telescope observations. We discuss the implications of this discovery for the spin state, figure, and thermal properties of Makemake and the apparent ubiquity of trans-Neptunian dwarf planet satellites.

  10. Polar Domain Discovery with Sparkler

    Science.gov (United States)

    Duerr, R.; Khalsa, S. J. S.; Mattmann, C. A.; Ottilingam, N. K.; Singh, K.; Lopez, L. A.

    2017-12-01

    The scientific web is vast and ever growing. It encompasses millions of textual, scientific and multimedia documents describing research in a multitude of scientific streams. Most of these documents are hidden behind forms which require user action to retrieve and thus can't be directly accessed by content crawlers. These documents are hosted on web servers across the world, most often on outdated hardware and network infrastructure. Hence it is difficult and time-consuming to aggregate documents from the scientific web, especially those relevant to a specific domain. Thus generating meaningful domain-specific insights is currently difficult. We present an automated discovery system (Figure 1) using Sparkler, an open-source, extensible, horizontally scalable crawler which facilitates high throughput and focused crawling of documents pertinent to a particular domain such as information about polar regions. With this set of highly domain relevant documents, we show that it is possible to answer analytical questions about that domain. Our domain discovery algorithm leverages prior domain knowledge to reach out to commercial/scientific search engines to generate seed URLs. Subject matter experts then annotate these seed URLs manually on a scale from highly relevant to irrelevant. We leverage this annotated dataset to train a machine learning model which predicts the `domain relevance' of a given document. We extend Sparkler with this model to focus crawling on documents relevant to that domain. Sparkler avoids disruption of service by 1) partitioning URLs by hostname such that every node gets a different host to crawl and by 2) inserting delays between subsequent requests. With an NSF-funded supercomputer Wrangler, we scaled our domain discovery pipeline to crawl about 200k polar specific documents from the scientific web, within a day.

  11. Guided Discovery with Socratic Questioning

    Directory of Open Access Journals (Sweden)

    M. Hakan Türkçapar

    2015-04-01

    Full Text Available “The Socratic method” is a way of teaching philosophical thinking and knowledge by asking questions. It was first used by in ancient times by the Greek philosopher Socrates who taught his followers by asking questions; these conversations between them are known as “Socratic dialogues”. In this methodology, no new knowledge is taught to the individual; rather, the individual is guided to remember and rediscover what was formerly known through this process. The main method used in cognitive therapy is guided discovery. There are various methods of guided discovery in cognitive therapy. The form of verbal exchange between the therapist and client which is used during the process of cognitive behavioral therapy is known as “socratic questioning”. In this method the goal is to make the client rediscover, with a series of questions, a piece of knowledge which he could otherwise know but is not presently conscious of. The Socratic Questioning consists of several steps, including: identifying the problem by listening to the client and making reflections, finding alternatives by examining and evaluating, reidentification by using the newly rediscovered information and questioning the old distorted belief, and reaching a new conclusion and applying it. Question types used during these procedures are: questions for collecting information, questions revealing meanings, questions revealing beliefs, questions about behaviours during similar past experiences, analytic questions and analytic synthesis questions. In order to make the patient feel understood, it is important to be empathetic and summarize the problem during the interview. In this text, steps of Socratic Questioning-Guided Discovery will be reviewed with sample dialogues provided for each step. [JCBPR 2015; 4(1.000: 47-53

  12. Knowledge discovery from data streams

    CERN Document Server

    Gama, Joao

    2010-01-01

    Since the beginning of the Internet age and the increased use of ubiquitous computing devices, the large volume and continuous flow of distributed data have imposed new constraints on the design of learning algorithms. Exploring how to extract knowledge structures from evolving and time-changing data, Knowledge Discovery from Data Streams presents a coherent overview of state-of-the-art research in learning from data streams.The book covers the fundamentals that are imperative to understanding data streams and describes important applications, such as TCP/IP traffic, GPS data, sensor networks,

  13. The discovery of uranium fission

    International Nuclear Information System (INIS)

    Brix, P.

    1990-01-01

    Uranium was discovered 200 years ago. Its radioactive character was first demonstrated in 1896 and two years later radium was extracted from uranium minerals. In 1911 studies with alpha rays from radioactive decay led to the unexpected discovery of the atomic nucleus. Exposure of beryllium to alpha rays yielded neutrons, first detected in 1932. Starting in 1934, neutron irradiation of uranium produced radioactive substances erroneously attributed to transuranium elements but with confusing properties. Painstaking experiments by chemists left no doubt on 17 December 1938 that barium was produced by these irradiations: the neutrons had split some uranium nuclei. The physics of the fission process was understood two weeks later; after a few months, neutron multiplication was found to be probable. This review deals with the eminent scientists involved, their successes, errors and disappointments, and the unexpected insights which occurred on the paths and detours of scientific research. It is, therefore, instructive also to discuss how fission was not discovered. The momentous discovery must be considered inevitable; the great tragedy was that Germany started World War II just at the time when the possibility of nuclear chain reactions and bombs became known. The consequences and anxieties that remain after 50 years of nuclear fission demand that mankind act with reason and conscience to maintain peace. (author)

  14. Astroparticle physics: puzzles and discoveries

    International Nuclear Information System (INIS)

    Berezinsky, V

    2008-01-01

    Puzzles often give birth to the great discoveries, the false discoveries sometimes stimulate the exiting ideas in theoretical physics. The historical examples of both are described in Introduction and in section 'Cosmological Puzzles'. From existing puzzles most attention is given to Ultra High Energy Cosmic Ray (UHECR) puzzle and to cosmological constant problem. The 40-years old UHECR problem consisted in absence of the sharp steepening in spectrum of extragalactic cosmic rays caused by interaction with CMB radiation. This steepening is known as Greisen-Zatsepin-Kuzmin (GZK) cutoff. It is demonstrated here that the features of interaction of cosmic ray protons with CMB are seen now in the spectrum in the form of the dip and beginning of the GZK cutoff. The most serious cosmological problem is caused by large vacuum energy of the known elementary-particle fields which exceeds at least by 45 orders of magnitude the cosmological vacuum energy. The various ideas put forward to solve this problem during last 40 years, have weaknesses and cannot be accepted as the final solution of this puzzle. The anthropic approach is discussed

  15. The discovery of radioactivity: the centenary

    International Nuclear Information System (INIS)

    Patil, S.K.

    1995-01-01

    In the last decade of the nineteenth century, a number of fundamental discoveries of outstanding importance were made unexpectedly which marked the beginning of a new era in physics. A cascade of spectacular discoveries began with the announcement of the discovery of x-rays by Roentgen followed by the discoveries, in quick succession, of radioactivity by Becquerel, of Zeeman effect, of electron by J.J. Thomson, and of polonium and radium by the Curies. Both x-rays and radioactivity have wide applications in scientific, medical and industrial fields and have made outstanding contribution to the advancement of human knowledge and welfare. Radioactivity is well known and no other discovery in the field of physics or chemistry has had a more profound effect on our fundamental knowledge of nature. Present article, on the occasion of the centenary of the discovery of radioactivity, makes an attempt to describe some glimpses of the history of radioactivity. (author). 59 refs

  16. Análisis de los deslizamiento en la cuenca de la Quebrada La Iguana de la ciudad de Medellín a partir de la integración lluvia _pendiente_ formación geológica

    Directory of Open Access Journals (Sweden)

    Oscar Echeverri

    2004-01-01

    Full Text Available En el lapso comprendido entre 1980 y 2001 se han registrado un total de 40 deslizamientos sobre las laderas de la cuenca de la quebrada La Iguaná al occidente de la ciudad de Medellín. En esta investigación se han analizado las relaciones de la ocurrencia de deslizamientos con los registros de precipitación precedente, la pendiente de la ladera y las distintas formaciones geológicas superficiales locales, estableciendo comparaciones con cada una de las mencionadas y con la interacción conjunta de las tres variables de análisis. El trabajo desarrollado ha permitido proponer un umbral de amenaza para precipitaciones antecedentes de 3 días y precedentes de 15 días, reconocer la susceptibilidad al deslizamiento de cada formación superficial y las pendientes más propensas a los movimientos en masa. La conjugación de las tres variables (precipitación, pendiente y formación superficial ha facilitado la elaboración de un mapa de amenaza por deslizamiento que se estima puede ser empleado como elemento en la ejecución de programas de prevención de desastres. La metodología propuesta permite, mediante la actualización de la información pluviométrica, que se detecten con antelación las áreas dentro de la cuenca en las cuales se puede presentar un deslizamiento, y puedan tomarse las acciones preventivas del caso. La concepción metodológica planteada permite en cualquier momento conocer la amenaza por deslizamiento con solo disponer de los registros de lluvia, lo que la constituye en una herramienta innovadora y de fácil manejo.

  17. mHealth Visual Discovery Dashboard.

    Science.gov (United States)

    Fang, Dezhi; Hohman, Fred; Polack, Peter; Sarker, Hillol; Kahng, Minsuk; Sharmin, Moushumi; al'Absi, Mustafa; Chau, Duen Horng

    2017-09-01

    We present Discovery Dashboard, a visual analytics system for exploring large volumes of time series data from mobile medical field studies. Discovery Dashboard offers interactive exploration tools and a data mining motif discovery algorithm to help researchers formulate hypotheses, discover trends and patterns, and ultimately gain a deeper understanding of their data. Discovery Dashboard emphasizes user freedom and flexibility during the data exploration process and enables researchers to do things previously challenging or impossible to do - in the web-browser and in real time. We demonstrate our system visualizing data from a mobile sensor study conducted at the University of Minnesota that included 52 participants who were trying to quit smoking.

  18. Discovery of massive neutral vector mesons

    International Nuclear Information System (INIS)

    Anon.

    1976-01-01

    Personal accounts of the discovery of massive neutral vector mesons (psi particles) are given by researchers S. Ting, G. Goldhaber, and B. Richter. The double-arm spectrometer and the Cherenkov effect are explained in a technical note, and the solenoidal magnetic detector is discussed in an explanatory note for nonspecialists. Reprints of three papers in Physical Review Letters which announced the discovery of the particles are given: Experimental observation of a heavy particle J, Discovery of a narrow resonance in e + e - annihilation, and Discovery of a second narrow resonance in e + e - annihilation. A discussion of subsequent developments and scientific biographies of the three authors are also presented. 25 figures

  19. Recent discoveries of anticancer flavonoids.

    Science.gov (United States)

    Raffa, Demetrio; Maggio, Benedetta; Raimondi, Maria Valeria; Plescia, Fabiana; Daidone, Giuseppe

    2017-12-15

    In this review we report the recent advances in anticancer activity of the family of natural occurring flavonoids, covering the time span of the last five years. The bibliographic data will be grouped, on the basis of biological information, in two great categories: reports in which the extract plants bioactivity is reported and the identification of each flavonoid is present or not, and reports in which the anticancer activity is attributable to purified and identified flavonoids from plants. Wherever possible, the targets and mechanisms of action as well as the structure-activity relationships of the molecules will be reported. Also, in the review it was thoroughly investigated the recent discovery on flavonoids containing the 2-phenyl-4H-chromen-4-one system even if some examples of unusual flavonoids, bearing a non-aromatic B-ring or other ring condensed to the base structure are reported. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  20. Specificity of discoveries in radiochemistry

    International Nuclear Information System (INIS)

    Krivomazov, A.N.

    1977-01-01

    The development of radiochemistry as a science is elucidated. On the basis of original papers and archives materials which have become available only recently, specific features of opening the law of radioactive displacements and isotopy of radioactive elements are presented in detail. A contribution of Hevesy, Russel, Fajans, and Soddy into the solution of this problem is considered; an important role of Rutherford in putting down the priority conflict is shown. Two stages of scientific generalization are singled out in the history of opening the law of radioactive displacements: the stage of the rules and the stage of the laws. On this basis the solutions of the priority problems have been reconsidered. It is shown that the history of radiochemistry is rich in discoveries which have undergone a relatively long evolution

  1. Big Data in Drug Discovery.

    Science.gov (United States)

    Brown, Nathan; Cambruzzi, Jean; Cox, Peter J; Davies, Mark; Dunbar, James; Plumbley, Dean; Sellwood, Matthew A; Sim, Aaron; Williams-Jones, Bryn I; Zwierzyna, Magdalena; Sheppard, David W

    2018-01-01

    Interpretation of Big Data in the drug discovery community should enhance project timelines and reduce clinical attrition through improved early decision making. The issues we encounter start with the sheer volume of data and how we first ingest it before building an infrastructure to house it to make use of the data in an efficient and productive way. There are many problems associated with the data itself including general reproducibility, but often, it is the context surrounding an experiment that is critical to success. Help, in the form of artificial intelligence (AI), is required to understand and translate the context. On the back of natural language processing pipelines, AI is also used to prospectively generate new hypotheses by linking data together. We explain Big Data from the context of biology, chemistry and clinical trials, showcasing some of the impressive public domain sources and initiatives now available for interrogation. © 2018 Elsevier B.V. All rights reserved.

  2. A Tale of Two Discoveries: Comparing the Usability of Summon and EBSCO Discovery Service

    Science.gov (United States)

    Foster, Anita K.; MacDonald, Jean B.

    2013-01-01

    Web-scale discovery systems are gaining momentum among academic libraries as libraries seek a means to provide their users with a one-stop searching experience. Illinois State University's Milner Library found itself in the unique position of having access to two distinct discovery products, EBSCO Discovery Service and Serials Solutions' Summon.…

  3. Accounting for discovery bias in genomic prediction

    Science.gov (United States)

    Our objective was to evaluate an approach to mitigating discovery bias in genomic prediction. Accuracy may be improved by placing greater emphasis on regions of the genome expected to be more influential on a trait. Methods emphasizing regions result in a phenomenon known as “discovery bias” if info...

  4. Intraday Price Discovery in Fragmented Markets

    NARCIS (Netherlands)

    S.R. Ozturk (Sait); M. van der Wel (Michel); D.J.C. van Dijk (Dick)

    2014-01-01

    textabstractFor many assets, trading is fragmented across multiple exchanges. Price discovery measures summarize the informativeness of trading on each venue for discovering the asset’s true underlying value. We explore intraday variation in price discovery using a structural model with

  5. 40 CFR 209.22 - Other discovery.

    Science.gov (United States)

    2010-07-01

    ... PRACTICE GOVERNING PROCEEDINGS UNDER THE NOISE CONTROL ACT OF 1972 Rules of Practice Governing Hearings for Orders Issued Under Section 11(d) of the Noise Control Act § 209.22 Other discovery. (a) Further... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Other discovery. 209.22 Section 209.22...

  6. 12 CFR 509.102 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Discovery. 509.102 Section 509.102 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY RULES OF PRACTICE AND PROCEDURE IN ADJUDICATORY PROCEEDINGS Local Rules § 509.102 Discovery. (a) In general. A party may take the deposition of an...

  7. 7 CFR 283.28 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Discovery. 283.28 Section 283.28 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE... Appeals of QC Claims of Less Than $50,000 § 283.28 Discovery. Upon motion and as ordered by the ALJ...

  8. 43 CFR 4.826 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... Review Under Part 17 of This Title-Nondiscrimination in Federally Assisted Programs of the Department of... the person from whom discovery is sought, and for good cause shown, the administrative law judge may make any order which justice requires to limit or condition discovery in order to protect a party or...

  9. Proteomic and metabolomic approaches to biomarker discovery

    CERN Document Server

    Issaq, Haleem J

    2013-01-01

    Proteomic and Metabolomic Approaches to Biomarker Discovery demonstrates how to leverage biomarkers to improve accuracy and reduce errors in research. Disease biomarker discovery is one of the most vibrant and important areas of research today, as the identification of reliable biomarkers has an enormous impact on disease diagnosis, selection of treatment regimens, and therapeutic monitoring. Various techniques are used in the biomarker discovery process, including techniques used in proteomics, the study of the proteins that make up an organism, and metabolomics, the study of chemical fingerprints created from cellular processes. Proteomic and Metabolomic Approaches to Biomarker Discovery is the only publication that covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution.  The book describes methods, and presents a standard operating procedure for sample selection, preparation, and storage, as well as data analysis...

  10. The discovery of the periodic table as a case of simultaneous discovery.

    Science.gov (United States)

    Scerri, Eric

    2015-03-13

    The article examines the question of priority and simultaneous discovery in the context of the discovery of the periodic system. It is argued that rather than being anomalous, simultaneous discovery is the rule. Moreover, I argue that the discovery of the periodic system by at least six authors in over a period of 7 years represents one of the best examples of a multiple discovery. This notion is supported by a new view of the evolutionary development of science through a mechanism that is dubbed Sci-Gaia by analogy with Lovelock's Gaia hypothesis. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

  11. Automated discovery systems and the inductivist controversy

    Science.gov (United States)

    Giza, Piotr

    2017-09-01

    The paper explores possible influences that some developments in the field of branches of AI, called automated discovery and machine learning systems, might have upon some aspects of the old debate between Francis Bacon's inductivism and Karl Popper's falsificationism. Donald Gillies facetiously calls this controversy 'the duel of two English knights', and claims, after some analysis of historical cases of discovery, that Baconian induction had been used in science very rarely, or not at all, although he argues that the situation has changed with the advent of machine learning systems. (Some clarification of terms machine learning and automated discovery is required here. The key idea of machine learning is that, given data with associated outcomes, software can be trained to make those associations in future cases which typically amounts to inducing some rules from individual cases classified by the experts. Automated discovery (also called machine discovery) deals with uncovering new knowledge that is valuable for human beings, and its key idea is that discovery is like other intellectual tasks and that the general idea of heuristic search in problem spaces applies also to discovery tasks. However, since machine learning systems discover (very low-level) regularities in data, throughout this paper I use the generic term automated discovery for both kinds of systems. I will elaborate on this later on). Gillies's line of argument can be generalised: thanks to automated discovery systems, philosophers of science have at their disposal a new tool for empirically testing their philosophical hypotheses. Accordingly, in the paper, I will address the question, which of the two philosophical conceptions of scientific method is better vindicated in view of the successes and failures of systems developed within three major research programmes in the field: machine learning systems in the Turing tradition, normative theory of scientific discovery formulated by Herbert Simon

  12. Swift: 10 Years of Discovery

    Science.gov (United States)

    2014-12-01

    The conference Swift: 10 years of discovery was held in Roma at La Sapienza University on Dec. 2-5 2014 to celebrate 10 years of Swift successes. Thanks to a large attendance and a lively program, it provided the opportunity to review recent advances of our knowledge of the high-energy transient Universe both from the observational and theoretical sides. When Swift was launched on November 20, 2004, its prime objective was to chase Gamma-Ray Bursts and deepen our knowledge of these cosmic explosions. And so it did, unveiling the secrets of long and short GRBs. However, its multi-wavelength instrumentation and fast scheduling capabilities made it the most versatile mission ever flown. Besides GRBs, Swift has observed, and contributed to our understanding of, an impressive variety of targets including AGNs, supernovae, pulsars, microquasars, novae, variable stars, comets, and much more. Swift is continuously discovering rare and surprising events distributed over a wide range of redshifts, out to the most distant transient objects in the Universe. Such a trove of discoveries has been addressed during the conference with sessions dedicated to each class of events. Indeed, the conference in Rome was a spectacular celebration of the Swift 10th anniversary. It included sessions on all types of transient and steady sources. Top scientists from around the world gave invited and contributed talks. There was a large poster session, sumptuous lunches, news interviews and a glorious banquet with officials attending from INAF and ASI. All the presentations, as well as several conference pictures, can be found in the conference website (http://www.brera.inaf.it/Swift10/Welcome.html). These proceedings have been collected owing to the efforts of Paolo D’Avanzo who has followed each paper from submission to final acceptance. Our warmest thanks to Paolo for all his work. The Conference has been made possible by the support from La Sapienza University as well as from the ARAP

  13. Discovery Mondays: Zoom on materials

    CERN Multimedia

    2003-01-01

    Following the success of the first Discovery Monday, which had over 100 visitors, the series of evening events in Microcosm continues. On Monday 2nd June, discover the world of materials. Find out how CERN scientists examine, manufacture and study different materials, at different scales. Did you know for example that using electrons you can observe a hair at a scale equivalent to looking at a boat with the naked eye? Also, that using ultrasound, you can measure the thickness of an object that is completely inaccessible? Find out more about these techniques, and also the high-tech machining and soldering that is carried out in CERN's central workshop. Plus, see how engineers can detect tiny leaks through solder points - essential for maintaining the vacuum in the LHC. The evening is open to all, without reservation, suggested age 12 and above. Rendez-vous in Microcosm on Monday 2nd June From 19.30 - 21.00 Free entry For more information : http://www.cern.ch/microcosm Using a scanning microscope, the head o...

  14. Mathematical models in biological discovery

    CERN Document Server

    Walter, Charles

    1977-01-01

    When I was asked to help organize an American Association for the Advancement of Science symposium about how mathematical models have con­ tributed to biology, I agreed immediately. The subject is of immense importance and wide-spread interest. However, too often it is discussed in biologically sterile environments by "mutual admiration society" groups of "theoreticians", many of whom have never seen, and most of whom have never done, an original scientific experiment with the biolog­ ical materials they attempt to describe in abstract (and often prejudiced) terms. The opportunity to address the topic during an annual meeting of the AAAS was irresistable. In order to try to maintain the integrity ;,f the original intent of the symposium, it was entitled, "Contributions of Mathematical Models to Biological Discovery". This symposium was organized by Daniel Solomon and myself, held during the 141st annual meeting of the AAAS in New York during January, 1975, sponsored by sections G and N (Biological and Medic...

  15. Knowledge Discovery from Vibration Measurements

    Directory of Open Access Journals (Sweden)

    Jun Deng

    2014-01-01

    Full Text Available The framework as well as the particular algorithms of pattern recognition process is widely adopted in structural health monitoring (SHM. However, as a part of the overall process of knowledge discovery from data bases (KDD, the results of pattern recognition are only changes and patterns of changes of data features. In this paper, based on the similarity between KDD and SHM and considering the particularity of SHM problems, a four-step framework of SHM is proposed which extends the final goal of SHM from detecting damages to extracting knowledge to facilitate decision making. The purposes and proper methods of each step of this framework are discussed. To demonstrate the proposed SHM framework, a specific SHM method which is composed by the second order structural parameter identification, statistical control chart analysis, and system reliability analysis is then presented. To examine the performance of this SHM method, real sensor data measured from a lab size steel bridge model structure are used. The developed four-step framework of SHM has the potential to clarify the process of SHM to facilitate the further development of SHM techniques.

  16. The Discovery of Dabigatran Etexilate

    Directory of Open Access Journals (Sweden)

    Joanne evan Ryn

    2013-02-01

    Full Text Available Thromboembolic disease is a major cause of mortality and morbidity in the developed world and is caused by an excessive stimulation of coagulation. Thrombin is a key serine protease in the coagulation cascade and numerous efforts have been made to develop safe and effective orally active direct thrombin inhibitors (DTIs. Current anticoagulant therapy includes the use of indirect thrombin inhibitors (e.g. heparins, low-molecular-weight-heparins [LMWHs] and vitamin K antagonists (VKA such as warfarin. However there are several caveats in the clinical use of these agents including narrow therapeutic window, parenteral delivery, and food- and drug-drug interactions. Dabigatran is a synthetic, reversible DTI with high affinity and specificity for its target binding both free and clot-bound thrombin, and offers a favorable pharmacokinetic profile. Large randomized clinical trials have demonstrated that dabigatran provides comparable or superior thromboprophylaxis in multiple thromboembolic disease indications compared to standard of care. This minireview will highlight the discovery and development of dabigatran, the first in a class of new oral anticoagulant (NOAC agents to be licensed worldwide for the prevention of thromboembolism in the setting of orthopedic surgery and stroke prevent in atrial fibrillation.

  17. West Nile Virus Drug Discovery

    Directory of Open Access Journals (Sweden)

    Siew Pheng Lim

    2013-12-01

    Full Text Available The outbreak of West Nile virus (WNV in 1999 in the USA, and its continued spread throughout the Americas, parts of Europe, the Middle East and Africa, underscored the need for WNV antiviral development. Here, we review the current status of WNV drug discovery. A number of approaches have been used to search for inhibitors of WNV, including viral infection-based screening, enzyme-based screening, structure-based virtual screening, structure-based rationale design, and antibody-based therapy. These efforts have yielded inhibitors of viral or cellular factors that are critical for viral replication. For small molecule inhibitors, no promising preclinical candidate has been developed; most of the inhibitors could not even be advanced to the stage of hit-to-lead optimization due to their poor drug-like properties. However, several inhibitors developed for related members of the family Flaviviridae, such as dengue virus and hepatitis C virus, exhibited cross-inhibition of WNV, suggesting the possibility to re-purpose these antivirals for WNV treatment. Most promisingly, therapeutic antibodies have shown excellent efficacy in mouse model; one of such antibodies has been advanced into clinical trial. The knowledge accumulated during the past fifteen years has provided better rationale for the ongoing WNV and other flavivirus antiviral development.

  18. Shotgun Proteomics and Biomarker Discovery

    Directory of Open Access Journals (Sweden)

    W. Hayes McDonald

    2002-01-01

    Full Text Available Coupling large-scale sequencing projects with the amino acid sequence information that can be gleaned from tandem mass spectrometry (MS/MS has made it much easier to analyze complex mixtures of proteins. The limits of this “shotgun” approach, in which the protein mixture is proteolytically digested before separation, can be further expanded by separating the resulting mixture of peptides prior to MS/MS analysis. Both single dimensional high pressure liquid chromatography (LC and multidimensional LC (LC/LC can be directly interfaced with the mass spectrometer to allow for automated collection of tremendous quantities of data. While there is no single technique that addresses all proteomic challenges, the shotgun approaches, especially LC/LC-MS/MS-based techniques such as MudPIT (multidimensional protein identification technology, show advantages over gel-based techniques in speed, sensitivity, scope of analysis, and dynamic range. Advances in the ability to quantitate differences between samples and to detect for an array of post-translational modifications allow for the discovery of classes of protein biomarkers that were previously unassailable.

  19. [Fortuitous discovery of gallbladder cancer].

    Science.gov (United States)

    Chiche, L; Metairie, S

    2001-12-01

    The prognosis of gallbladder cancer is basically dependent on the histological stage at diagnosis. In practice, the discovery of a small cancer of the bladder, generally during cholecystectomy give the patient a better care for curative treatment. The advent of laparoscopy has increased the number of cholecstectomies and could increase the frequency of this situation but also raises the difficult problem of metastatic dissemination. In the literature the figures on parietal metastasis after laparoscopy have ranged from 125% to 19%. The median delay to diagnosis of recurrence is 6 months. The cause of this phenomenon (role of the pneumoperitoneum) remains poorly elucidated. Risk factors for the development of a metastasis on the trocar orifice are: rupture of the gallbladder perioperatively and extraction of the gallbladder without protection. It is important to keep in mind this exceptional but serious risk and apply rigorous operative technique. In case of suspected gallbladder we do not advocate laparoscopy. Surgery (hepatectomy, lymphodenectomy, possibly resection of the biliary tract) would be indicted for all stages except pTis and T1a, taking into consideration the localization of the tumor and the patient's general status. It is also classical to recommend resection of the trocar orifices after laparoscopic cholecystectomy. There is a dual challenge today for small-sized gallbladder cancer: improving treatment and avoiding poorer prognosis due to the specific problems raised by laparoscopy.

  20. NIF Discovery Science Eagle Nebula

    Science.gov (United States)

    Kane, Jave; Martinez, David; Pound, Marc; Heeter, Robert; Casner, Alexis; Villette, Bruno; Mancini, Roberto

    2017-10-01

    The University of Maryland and and LLNL are investigating the origin and dynamics of the famous Pillars of the Eagle Nebula and similar parsec-scale structures at the boundaries of HII regions in molecular hydrogen clouds. The National Ignition Facility (NIF) Discovery Science program Eagle Nebula has performed NIF shots to study models of pillar formation. The shots feature a new long-duration x-ray source, in which multiple hohlraums mimicking a cluster of stars are driven with UV light in series for 10 to 15 ns each to create a 30 to 60 ns output x-ray pulse. The source generates deeply nonlinear hydrodynamics in the Eagle science package, a structure of dense plastic and foam mocking up a molecular cloud containing a dense core. Omega EP and NIF shots have validated the source concept, showing that earlier hohlraums do not compromise later ones by preheat or by ejecting ablated plumes that deflect later beams. The NIF shots generated radiographs of shadowing-model pillars, and also showed evidence that cometary structures can be generated. The velocity and column density profiles of the NIF shadowing and cometary pillars have been compared with observations of the Eagle Pillars made at the millimeter-wave BIMA and CARMA observatories. Prepared by LLNL under Contract DE-AC52-07NA27344.

  1. Discovery of Uniformly Expanding Universe

    Directory of Open Access Journals (Sweden)

    Cahill R. T.

    2012-01-01

    Full Text Available Saul Perlmutter and the Brian Schmidt – Adam Riess teams reported that their Friedmann-model GR-based analysis of their supernovae magnitude-redshift data re- vealed a new phenomenon of “dark energy” which, it is claimed, forms 73% of the energy / matter density of the present-epoch universe, and which is linked to the further claim of an accelerating expansion of the universe. In 2011 Perlmutter, Schmidt and Riess received the Nobel Prize in Physics “for the discovery of the accelerating ex- pansion of the Universe through observations of distant supernovae”. Here it is shown that (i a generic model-independent analysis of this data reveals a uniformly expanding universe, (ii their analysis actually used Newtonian gravity, and finally (iii the data, as well as the CMB fluctuation data, does not require “dark energy” nor “dark matter”, but instead reveals the phenomenon of a dynamical space, which is absent from the Friedmann model.

  2. Students Excited by Stellar Discovery

    Science.gov (United States)

    2011-02-01

    In the constellation of Ophiuchus, above the disk of our Milky Way Galaxy, there lurks a stellar corpse spinning 30 times per second -- an exotic star known as a radio pulsar. This object was unknown until it was discovered last week by three high school students. These students are part of the Pulsar Search Collaboratory (PSC) project, run by the National Radio Astronomy Observatory (NRAO) in Green Bank, WV, and West Virginia University (WVU). The pulsar, which may be a rare kind of neutron star called a recycled pulsar, was discovered independently by Virginia students Alexander Snider and Casey Thompson, on January 20, and a day later by Kentucky student Hannah Mabry. "Every day, I told myself, 'I have to find a pulsar. I better find a pulsar before this class ends,'" said Mabry. When she actually made the discovery, she could barely contain her excitement. "I started screaming and jumping up and down." Thompson was similarly expressive. "After three years of searching, I hadn't found a single thing," he said, "but when I did, I threw my hands up in the air and said, 'Yes!'." Snider said, "It actually feels really neat to be the first person to ever see something like that. It's an uplifting feeling." As part of the PSC, the students analyze real data from NRAO's Robert C. Byrd Green Bank Telescope (GBT) to find pulsars. The students' teachers -- Debra Edwards of Sherando High School, Leah Lorton of James River High School, and Jennifer Carter of Rowan County Senior High School -- all introduced the PSC in their classes, and interested students formed teams to continue the work. Even before the discovery, Mabry simply enjoyed the search. "It just feels like you're actually doing something," she said. "It's a good feeling." Once the pulsar candidate was reported to NRAO, Project Director Rachel Rosen took a look and agreed with the young scientists. A followup observing session was scheduled on the GBT. Snider and Mabry traveled to West Virginia to assist in the

  3. Functional principles of registry-based service discovery

    NARCIS (Netherlands)

    Sundramoorthy, V.; Tan, C.; Hartel, P.H.; Hartog, den J.I.; Scholten, J.

    2005-01-01

    As Service Discovery Protocols (SDP) are becoming increasingly important for ubiquitous computing, they must behave according to predefined principles. We present the functional Principles of Service Discovery for robust, registry-based service discovery. A methodology to guarantee adherence to

  4. Systems biology and biomarker discovery

    Energy Technology Data Exchange (ETDEWEB)

    Rodland, Karin D.

    2010-12-01

    Medical practitioners have always relied on surrogate markers of inaccessible biological processes to make their diagnosis, whether it was the pallor of shock, the flush of inflammation, or the jaundice of liver failure. Obviously, the current implementation of biomarkers for disease is far more sophisticated, relying on highly reproducible, quantitative measurements of molecules that are often mechanistically associated with the disease in question, as in glycated hemoglobin for the diagnosis of diabetes [1] or the presence of cardiac troponins in the blood for confirmation of myocardial infarcts [2]. In cancer, where the initial symptoms are often subtle and the consequences of delayed diagnosis often drastic for disease management, the impetus to discover readily accessible, reliable, and accurate biomarkers for early detection is compelling. Yet despite years of intense activity, the stable of clinically validated, cost-effective biomarkers for early detection of cancer is pathetically small and still dominated by a handful of markers (CA-125, CEA, PSA) first discovered decades ago. It is time, one could argue, for a fresh approach to the discovery and validation of disease biomarkers, one that takes full advantage of the revolution in genomic technologies and in the development of computational tools for the analysis of large complex datasets. This issue of Disease Markers is dedicated to one such new approach, loosely termed the 'Systems Biology of Biomarkers'. What sets the Systems Biology approach apart from other, more traditional approaches, is both the types of data used, and the tools used for data analysis - and both reflect the revolution in high throughput analytical methods and high throughput computing that has characterized the start of the twenty first century.

  5. Biomarkers: in medicine, drug discovery, and environmental health

    National Research Council Canada - National Science Library

    Vaidya, Vishal S; Bonventre, Joseph V

    2010-01-01

    ... Identification Using Mass Spectrometry Sample Preparation Protein Quantitation Examples of Biomarker Discovery and Evaluation Challenges in Proteomic Biomarker Discovery The Road Forward: Targeted ...

  6. HIDROFOBICIDAD EN ANDISOLES BAJO ROBLEDAL (Quercus humboldtii Y PLANTACIONES FORESTALES (Pinus patula y Cupressus lusitanica EN LA CUENCA DE LA QUEBRADA PIEDRAS BLANCAS (MEDELLÍN, COLOMBIA HYDROPHOBICITY OF ANDISOLS OF OAK GROVES (Quercus humboldtii AND TREE PLANTATIONS (Pinus patula and Cupressus lusitanica IN THE PIEDRAS BLANCAS WATERSHED ( MEDELLÍN, COLOMBIA

    Directory of Open Access Journals (Sweden)

    Juan Raúl Duque Zapata

    2004-12-01

    Full Text Available En la cuenca de la quebrada Piedras Blancas se evaluó la persistencia de la repelencia al agua en el horizonte A de Andisoles bajo tres coberturas vegetales: Pinus patula, Cupressus lusitanica y Quercus humboldtii y en tres posiciones topográficas diferentes a lo largo de la vertiente de colinas bajas, mediante el método de WDPT, en muestras con la humedad de campo y secas al aire. En todas las coberturas se encontró repelencia al agua en los suelos. Además, cuando las muestras fueron secadas al aire, la persistencia de la repelencia al agua se incrementó. Se encontró diferencia significativa en la distribución de la persistencia de la repelencia al agua entre las coberturas y entre las posiciones en la vertiente de las colinas, sin que se presentara un comportamiento similar para las tres coberturas. Los suelos bajo cobertura de ciprés fueron los que presentaron los mayores valores de WDPT en todas las condiciones de medida, siendo este el primer reporte que se hace en la literatura, con un amplio respaldo muestral, de repelencia al agua en suelos bajo dicha cobertura vegetal. En ninguno de los casos, la humedad de las muestras fue el parámetro que explicara el comportamiento observado en la repelencia al agua de los suelos estudiados.The persistence of water repellency in the A horizon of Andisols was evaluated in the Piedras Blancas watershed under three vegetative covers: Pinus patula, Cupressus lusitanica, and Quercus humboldtii, and in three different topographic conditions across the slope of a low hill, using the WDPT method with samples containing field humidities and airdried samples. In all vegetative covers, water repellency of the soils was documented. Also, when the samples were air-dried, the persistency of the water repellency increased. A significant difference in the distribution of water repellency was documented among the different vegetative covers and topographic conditions, without a consistent pattern for the

  7. ‘¡Y tenemos que ser más unidos!’: Carnaval y Política en una zona rural de la Quebrada de Humahuaca, o cómo mantener las tradiciones que se pierden en el pueblo

    Directory of Open Access Journals (Sweden)

    Guillermina Espósito

    2009-04-01

    Full Text Available Desde hace algunos años, las reflexiones académicas que desde la Antropología se han desarrolladoacerca de diversos eventos de la vida social, vienen enfatizando la dimensión performática de ciertosgéneros dramáticos, como es el caso de los rituales y las fiestas. En el marco de los trabajos de campoetnográficos llevados a cabo durante el verano de 2008, tuvimos la oportunidad de participar en losdistintos eventos que conforman el carnaval que todos los años se festeja en la quebrada de PipintuGrande, Jujuy. Inmersos en el clima festivo del carnaval, intentando tomar el pulso de los rituales dedesentierro y entierro, tan prolíficos en coplas de inusitado ingenio como en ch’allas y machas,comenzamos a reflexionar acerca de los modos de articulación entre los géneros performáticos, lasidentidades puestas en juego y los procesos de resistencia que se modulan en torno a una tensiónentre la percepción de un devenir agonístico que amenaza la unión interfamiliar, amenaza representadaen la política, y la puesta en acto de elementos simbólicos ‘tradicionales’, donde el miedo a la pérdidade las tradiciones y costumbres articulan los discursos que se despliegan durante el carnaval.AbstractSince some years ago, the academic reflections that from the Anthropology have been developedabout diverse events of the social life, emphasize the performatic dimension of certain dramatic genres,as the cases of rituals and parties. In the frame of the ethnographic field works carried out during thesummer of 2008, we had the opportunity to take part in the different events that shape the carnivalthat every year is feasted in the gorge of Pipintu Grande, Jujuy. Immersed in the festive climate of thecarnival, trying to take the pulse of the rituals of the ‘entierro’ and the ‘desentierro’, so prolific ofcouplets of unusual ingenuity as in ‘ch’allas’ and ‘machas’, we began to think about the manners ofarticulation between the

  8. Effective Online Group Discovery in Trajectory Databases

    DEFF Research Database (Denmark)

    Li, Xiaohui; Ceikute, Vaida; Jensen, Christian S.

    2013-01-01

    GPS-enabled devices are pervasive nowadays. Finding movement patterns in trajectory data stream is gaining in importance. We propose a group discovery framework that aims to efficiently support the online discovery of moving objects that travel together. The framework adopts a sampling-independen......GPS-enabled devices are pervasive nowadays. Finding movement patterns in trajectory data stream is gaining in importance. We propose a group discovery framework that aims to efficiently support the online discovery of moving objects that travel together. The framework adopts a sampling......-independent approach that makes no assumptions about when positions are sampled, gives no special importance to sampling points, and naturally supports the use of approximate trajectories. The framework's algorithms exploit state-of-the-art, density-based clustering (DBScan) to identify groups. The groups are scored...

  9. Drug discovery and developments in developing countries ...

    African Journals Online (AJOL)

    the major burden being in developing countries. Many of ... The driving force for drug discovery and development by pharmaceutical firms ... world and particularly in the third world countries ..... GFHR (2000) Global Forum for Health Research:.

  10. Story of Superconductivity: A Serendipitous Discovery

    Indian Academy of Sciences (India)

    , offered a glimmerof hope to make this dream possible. It was a discoverytotally unexpected at that time, and we owe this discovery tothe painstaking andmethodical investigations of Onnes – firstto produce very low temperatures, and then ...

  11. Discovery of nuclear fission in Berlin 1938

    International Nuclear Information System (INIS)

    Hilscher, D.

    1989-01-01

    The story of the discovery of nuclear fission, one of the most exciting stories of how a scientific puzzle was finally solved and how the scientists involved were blind to many obvious indications, is described. (author). 29 refs

  12. Discovery of two new gravitation lens systems

    International Nuclear Information System (INIS)

    Guertler, J.

    1988-01-01

    The discovery of new quasar and radio galaxy double images produced by the gravitation lens effect is reported. The light deflecting galaxies acting as gravitational lenses could be made visible by means of image processing procedures

  13. Queen's discovery lauded by top scientific journal

    CERN Multimedia

    McGrady, S

    2002-01-01

    A scientific breakthrough at Queen's University's Sudbury Neutrino Observatory has received major international recognition. The journal Science ranked the discovery that cracked the "neutrino problem" second, in the journal's top 10 scientific achievements of 2002 (1/2 page).

  14. Price discovery in European natural gas markets

    International Nuclear Information System (INIS)

    Schultz, Emma; Swieringa, John

    2013-01-01

    We provide the first high-frequency investigation of price discovery within the physical and financial layers of Europe's natural gas markets. Testing not only looks at short-term return dynamics, but also considers each security's contribution to price equilibrium in the longer-term. Results show that UK natural gas futures traded on the Intercontinental Exchange display greater price discovery than physical trading at various hubs throughout Europe. - Highlights: • We use intraday data to gauge price discovery in European natural gas markets. • We explore short and long-term dynamics in physical and financial market layers. • Results show ICE's UK natural gas futures are the main venue for price discovery

  15. Discovery of Intrinsic Primitives on Triangle Meshes

    KAUST Repository

    Solomon, Justin; Ben-Chen, Mirela; Butscher, Adrian; Guibas, Leonidas

    2011-01-01

    The discovery of meaningful parts of a shape is required for many geometry processing applications, such as parameterization, shape correspondence, and animation. It is natural to consider primitives such as spheres, cylinders and cones

  16. The Uniframe .Net Web Service Discovery Service

    National Research Council Canada - National Science Library

    Berbeco, Robert W

    2003-01-01

    ...) and registered with Internet Information Server (IIS), and can be applied in numerous fashions This project uses the NET capabilities to create a distributed discovery service (called as UNWSDS...

  17. The discovery of the structure of DNA

    Science.gov (United States)

    Squires, G. L.

    2003-04-01

    On 25 April 1953, Nature published a letter by Francis Crick and James Watson, at the Cavendish Laboratory, Cambridge, proposing a structure for DNA. This letter marked the beginning of a revolution in biology. Besides Crick and Watson, two other scientists, Rosalind Franklin and Maurice Wilkins, played key roles in the discovery. After sketching the early careers of the four scientists, the present article gives an account of the physics and chemistry involved in the discovery, and the events leading up to it.

  18. Fission and the discovery of isotopes

    International Nuclear Information System (INIS)

    Thoennessen, M.

    2014-01-01

    The discovery of new isotopes requires new developments in accelerator and detector technology. The new RI Beam Factory at RIKEN and the future projects FAIR at GSI and FRIB at MSU promise to expand the nuclear horizon even further. In the talk a short history of the role that fission played in the discovery of isotopes will be presented and future perspectives will be discussed

  19. The Gozo discovery bus : a successful experiment

    OpenAIRE

    Vella, Maryrose

    2008-01-01

    The introduction of a tourist discovery bus in Gozo came about as a result of an EU Project which is part of the Interreg III B Archimed programmes in which the Islands and Small States Institute of the University of Malta participated. Other countries participating in this programme besides Malta, represented by the Islands and Small States Institute, are Italy, Cyprus and Greece. The discovery bus service was aimed at encouraging more tourists to come to Gozo and enabling them to visit stra...

  20. Discovery of the Higgs boson and beyond

    International Nuclear Information System (INIS)

    Godbole, Rohini

    2014-01-01

    This talk is about the Higgs mechanism, the theoretical discovery of which, was awarded the 2013 Nobel Prize. It also discusses the discovery of the Higgs boson at the large hadron collider which provided the experimental proof that made the Nobel prize possible. It covers the implications of these for the quest of unravelling the fundamental laws of nature which seem to govern both, the behavior of the ultra small (subatomic particles) and the ultra large (the cosmos)

  1. Studying Scientific Discovery by Computer Simulation.

    Science.gov (United States)

    1983-03-30

    Mendel’s laws of inheritance, the law of Gay- Lussac for gaseous reactions, tile law of Dulong and Petit, the derivation of atomic weights by Avogadro...neceseary mid identify by block number) scientific discovery -ittri sic properties physical laws extensive terms data-driven heuristics intensive...terms theory-driven heuristics conservation laws 20. ABSTRACT (Continue on revere. side It necessary and identify by block number) Scientific discovery

  2. Applying genetics in inflammatory disease drug discovery

    DEFF Research Database (Denmark)

    Folkersen, Lasse; Biswas, Shameek; Frederiksen, Klaus Stensgaard

    2015-01-01

    , with several notable exceptions, the journey from a small-effect genetic variant to a functional drug has proven arduous, and few examples of actual contributions to drug discovery exist. Here, we discuss novel approaches of overcoming this hurdle by using instead public genetics resources as a pragmatic guide...... alongside existing drug discovery methods. Our aim is to evaluate human genetic confidence as a rationale for drug target selection....

  3. Roentgen and the discovery of X rays

    International Nuclear Information System (INIS)

    Gueret, Ph.

    1998-01-01

    In 1901, the first Nobel price of physics was attributed to Roentgen for his discovery of X rays. This paper recalls through the career of this physicist and research worker, the different steps that led him to this discovery. This paper tries also to solve the 'Roentgen mystery', i.e. the reasons that led him to stop his research work just after this exploit. (J.S.)

  4. Shuttle Discovery Landing at Edwards

    Science.gov (United States)

    1989-01-01

    The STS-29 Space Shuttle Discovery mission lands at NASA's then Ames-Dryden Flight Research Facility, Edwards AFB, California, early Saturday morning, 18 March 1989. Touchdown was at 6:35:49 a.m. PST and wheel stop was at 6:36:40 a.m. on runway 22. Controllers chose the concrete runway for the landing in order to make tests of braking and nosewheel steering. The STS-29 mission was very successful, completing the launch of a Tracking and Data Relay communications satellite, as well as a range of scientific experiments. Discovery's five-man crew was led by Commander Michael L. Coats, and included pilot John E. Blaha and mission specialists James P. Bagian, Robert C. Springer, and James F. Buchli. Space Shuttles are the main element of America's Space Transportation System and are used for space research and other space applications. The shuttles are the first vehicles capable of being launched into space and returning to Earth on a routine basis. Space Shuttles are used as orbiting laboratories in which scientists and mission specialists conduct a wide variety of scientific experiments. Crews aboard shuttles place satellites in orbit, rendezvous with satellites to carry out repair missions and return them to space, and retrieve satellites and return them to Earth for refurbishment and reuse. Space Shuttles are true aerospace vehicles. They leave Earth and its atmosphere under rocket power provided by three liquid-propellant main engines with two solid-propellant boosters attached plus an external liquid-fuel tank. After their orbital missions, they streak back through the atmosphere and land like airplanes. The returning shuttles, however, land like gliders, without power and on runways. Other rockets can place heavy payloads into orbit, but, they can only be used once. Space Shuttles are designed to be continually reused. When Space Shuttles are used to transport complete scientific laboratories into space, the laboratories remain inside the payload bay throughout

  5. Reporting Astronomical Discoveries: Past, Now, and Future

    Science.gov (United States)

    Yamaoka, Hitoshi; Green, Daniel W. E.; Samus, Nikolai N.; West, Richard

    2015-08-01

    Many new astronomical objects have been discovered over the years by amateur astronomers, and this continues to be the case. They have traditionally reported them (as have professional astronomers) to the Central Bureau for Astronomical Telegrams (CBAT), which was established in the 19th century. This procedure has worked very well throughout the 20th century, moving under the umbrella of the newly established IAU in 1920. The discoverers have been honored by the formal announcement of their discoveries in the publications of the CBAT.In recent years, some professional research groups have established other ways of announcing their discoveries of explosive objects such as novae and supernovae; some do not now report their discoveries or spectroscopic confirmations of the transients to the CBAT, including often spectroscopic reports of objects posted to the CBAT "Transient Objects Confirmation Page" -- the highly successful TOCP webpage, which assigns official positional designations to new transients posted there by approved, registered users. This leads to a delay in formal announcements of discoveries by amateur astronomers in many cases, as well as inconsistent designations being put into use by individual groups. Amateur astronomers are feeling frustrated about this situation, and they hope that the IAU will help to settle the situation.We have proposed the new IAU commission NC-52, which will treat these phenomena in a continuation of Commission 6, through the CBAT. We hope to continuously support the reporting of the discoveries by amateur astronomers, as well as professional astronomers, who all deserve and desire proper recognition. Our strategy will maintain the firm trust between the amateur and professional astronomers, which is necessary for true collaboration. The plan is for the CBAT to work with collaborators to assure that discoveries posted on the TOCP are promptly designated and announced by the CBAT, even when confirmations are made elsewhere

  6. 12 CFR 747.24 - Scope of document discovery.

    Science.gov (United States)

    2010-01-01

    ... act of Congress, or the principles of common law provide. (d) Time limits. All discovery, including... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Scope of document discovery. 747.24 Section 747... of Practice and Procedure § 747.24 Scope of document discovery. (a) Limits on discovery. (1) Subject...

  7. Choosing Discovery: A Literature Review on the Selection and Evaluation of Discovery Layers

    Science.gov (United States)

    Moore, Kate B.; Greene, Courtney

    2012-01-01

    Within the next few years, traditional online public access catalogs will be replaced by more robust and interconnected discovery layers that can serve as primary public interfaces to simultaneously search many separate collections of resources. Librarians have envisioned this type of discovery tool since the 1980s, and research shows that…

  8. Resource-estimation models and predicted discovery

    International Nuclear Information System (INIS)

    Hill, G.W.

    1982-01-01

    Resources have been estimated by predictive extrapolation from past discovery experience, by analogy with better explored regions, or by inference from evidence of depletion of targets for exploration. Changes in technology and new insights into geological mechanisms have occurred sufficiently often in the long run to form part of the pattern of mature discovery experience. The criterion, that a meaningful resource estimate needs an objective measure of its precision or degree of uncertainty, excludes 'estimates' based solely on expert opinion. This is illustrated by development of error measures for several persuasive models of discovery and production of oil and gas in USA, both annually and in terms of increasing exploration effort. Appropriate generalizations of the models resolve many points of controversy. This is illustrated using two USA data sets describing discovery of oil and of U 3 O 8 ; the latter set highlights an inadequacy of available official data. Review of the oil-discovery data set provides a warrant for adjusting the time-series prediction to a higher resource figure for USA petroleum. (author)

  9. On reliable discovery of molecular signatures

    Directory of Open Access Journals (Sweden)

    Björkegren Johan

    2009-01-01

    Full Text Available Abstract Background Molecular signatures are sets of genes, proteins, genetic variants or other variables that can be used as markers for a particular phenotype. Reliable signature discovery methods could yield valuable insight into cell biology and mechanisms of human disease. However, it is currently not clear how to control error rates such as the false discovery rate (FDR in signature discovery. Moreover, signatures for cancer gene expression have been shown to be unstable, that is, difficult to replicate in independent studies, casting doubts on their reliability. Results We demonstrate that with modern prediction methods, signatures that yield accurate predictions may still have a high FDR. Further, we show that even signatures with low FDR may fail to replicate in independent studies due to limited statistical power. Thus, neither stability nor predictive accuracy are relevant when FDR control is the primary goal. We therefore develop a general statistical hypothesis testing framework that for the first time provides FDR control for signature discovery. Our method is demonstrated to be correct in simulation studies. When applied to five cancer data sets, the method was able to discover molecular signatures with 5% FDR in three cases, while two data sets yielded no significant findings. Conclusion Our approach enables reliable discovery of molecular signatures from genome-wide data with current sample sizes. The statistical framework developed herein is potentially applicable to a wide range of prediction problems in bioinformatics.

  10. Predicting future discoveries from current scientific literature.

    Science.gov (United States)

    Petrič, Ingrid; Cestnik, Bojan

    2014-01-01

    Knowledge discovery in biomedicine is a time-consuming process starting from the basic research, through preclinical testing, towards possible clinical applications. Crossing of conceptual boundaries is often needed for groundbreaking biomedical research that generates highly inventive discoveries. We demonstrate the ability of a creative literature mining method to advance valuable new discoveries based on rare ideas from existing literature. When emerging ideas from scientific literature are put together as fragments of knowledge in a systematic way, they may lead to original, sometimes surprising, research findings. If enough scientific evidence is already published for the association of such findings, they can be considered as scientific hypotheses. In this chapter, we describe a method for the computer-aided generation of such hypotheses based on the existing scientific literature. Our literature-based discovery of NF-kappaB with its possible connections to autism was recently approved by scientific community, which confirms the ability of our literature mining methodology to accelerate future discoveries based on rare ideas from existing literature.

  11. Bioinformatics for discovery of microbiome variation

    DEFF Research Database (Denmark)

    Brejnrod, Asker Daniel

    of various molecular methods to build hypotheses about the impact of a copper contaminated soil. The introduction is a broad introduction to the field of microbiome research with a focus on the technologies that enable these discoveries and how some of the broader issues have related to this thesis......Sequencing based tools have revolutionized microbiology in recent years. Highthroughput DNA sequencing have allowed high-resolution studies on microbial life in many different environments and at unprecedented low cost. These culture-independent methods have helped discovery of novel bacteria...... 1 ,“Large-scale benchmarking reveals false discoveries and count transformation sensitivity in 16S rRNA gene amplicon data analysis methods used in microbiome studies”, benchmarked the performance of a variety of popular statistical methods for discovering differentially abundant bacteria . between...

  12. Neutron Diffraction and Inorganic Materials Discovery

    International Nuclear Information System (INIS)

    Rosseinsky, M.J.

    2005-01-01

    Full text: The discovery of complex inorganic materials is an important academic and technological challenge because of the opportunities these systems offer for observation of new phenomena, and the questions they pose for fundamental understanding. This presentation will illustrate the key role of neutron powder diffraction in enabling the discovery of new classes of materials, and in evaluating their properties and the conditions under which they need to be processed to optimise their behaviour in devices for applications. New chemistry is illustrated by the transition metal oxide hydrides, where both structure and ionic mobility required neutron scattering characterisation. The relationship between chemistry, structure and properties will be addressed by considering the difficulties in inducing superconductivity in analogues of magnesium diboride. The role of both neutron and X-ray diffraction in evaluating the processing of microwave dielectric ceramics will be highlighted, with the discovery of new phases shown to be a useful bonus in this type of in-situ study. (author)

  13. Virtual drug discovery: beyond computational chemistry?

    Science.gov (United States)

    Gilardoni, Francois; Arvanites, Anthony C

    2010-02-01

    This editorial looks at how a fully integrated structure that performs all aspects in the drug discovery process, under one company, is slowly disappearing. The steps in the drug discovery paradigm have been slowly increasing toward virtuality or outsourcing at various phases of product development in a company's candidate pipeline. Each step in the process, such as target identification and validation and medicinal chemistry, can be managed by scientific teams within a 'virtual' company. Pharmaceutical companies to biotechnology start-ups have been quick in adopting this new research and development business strategy in order to gain flexibility, access the best technologies and technical expertise, and decrease product developmental costs. In today's financial climate, the term virtual drug discovery has an organizational meaning. It represents the next evolutionary step in outsourcing drug development.

  14. Predictors of timing of pregnancy discovery.

    Science.gov (United States)

    McCarthy, Molly; Upadhyay, Ushma; Biggs, M Antonia; Anthony, Renaisa; Holl, Jennifer; Roberts, Sarah Cm

    2018-04-01

    Earlier pregnancy discovery is important in the context of prenatal and abortion care. We evaluated characteristics associated with later pregnancy discovery among women seeking abortion care. Data come from a survey of women seeking abortion care at four family planning facilities in Utah. The participants completed a survey during the state-mandated abortion information visit they are required to complete prior to having an abortion. The outcome in this study was pregnancy discovery before versus after 6 weeks since respondents' last menstrual period (LMP). We used logistic regression to estimate the relationship between sociodemographic and health-related independent variables of interest and pregnancy discovery before versus after 6 weeks. Among the 458 women in the sample, 28% discovered their pregnancy later than 6 weeks since LMP. Most (n=366, 80%) knew the exact date of their LMP and a significant minority estimated it (n=92, 20%). Those who estimated the date of their LMP had higher odds of later pregnancy discovery than those who knew the exact date (adjusted odds ratio (aOR)=1.81[1.07-3.07]). Those who used illicit drugs weekly, daily, or almost daily had higher odds of later pregnancy discovery (aOR=6.33[2.44, 16.40]). Women who did not track their menstrual periods and those who frequently used drugs had higher odds of discovering their pregnancies later. Women who estimated the date of their LMP and who frequently used drugs may benefit from strategies to help them recognize their pregnancies earlier and link them to care when they discover their pregnancies later. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Net present value approaches for drug discovery.

    Science.gov (United States)

    Svennebring, Andreas M; Wikberg, Jarl Es

    2013-12-01

    Three dedicated approaches to the calculation of the risk-adjusted net present value (rNPV) in drug discovery projects under different assumptions are suggested. The probability of finding a candidate drug suitable for clinical development and the time to the initiation of the clinical development is assumed to be flexible in contrast to the previously used models. The rNPV of the post-discovery cash flows is calculated as the probability weighted average of the rNPV at each potential time of initiation of clinical development. Practical considerations how to set probability rates, in particular during the initiation and termination of a project is discussed.

  16. Toward discovery science of human brain function

    DEFF Research Database (Denmark)

    Biswal, Bharat B; Mennes, Maarten; Zuo, Xi-Nian

    2010-01-01

    Although it is being successfully implemented for exploration of the genome, discovery science has eluded the functional neuroimaging community. The core challenge remains the development of common paradigms for interrogating the myriad functional systems in the brain without the constraints...... individual's functional connectome exhibits unique features, with stable, meaningful interindividual differences in connectivity patterns and strengths. Comprehensive mapping of the functional connectome, and its subsequent exploitation to discern genetic influences and brain-behavior relationships...... in the brain. To initiate discovery science of brain function, the 1000 Functional Connectomes Project dataset is freely accessible at www.nitrc.org/projects/fcon_1000/....

  17. Henri Becquerel: the discovery of radioactivity

    International Nuclear Information System (INIS)

    Allisy, A.

    1996-01-01

    This paper recalls the history of the Becquerel family, the fascinating time of the discovery of radioactivity as well as some important related research published before the radium age. Henri Becquerel was the third in the line of a family of scientists which extended over more than a hundred years. Following in the footsteps of his father and grandfather gave him a thorough grounding in scientific research methods. Science at the turn of the century was very exciting, the discovery of X rays had just been announced and scientists everywhere were hoping to discover new phenomena. (author)

  18. Using Discovery Learning to Encourage Creative Thinking

    Directory of Open Access Journals (Sweden)

    Mardia Hi. Rahman

    2017-10-01

    Full Text Available Creative thinking ability development is needed to be implemented by every educator including lecturers to their students. Therefore, they need to seriously act and design their learning process. One of the ways to develop student’s creative thinking is using discovery learning model. This research is conducted in physics education study program in 2016 with students who took learning and teaching class as research subject. From the research analysis result and discussion, it can be concluded that discovery learning model can encourage students’ creative thinking ability in learning and teaching strategy subject.

  19. The discovery of the tau lepton

    International Nuclear Information System (INIS)

    Perl, M.L.

    1992-09-01

    The discovery of the tau lepton and the third generation of fermions came from the convergence of three physics streams in the late 1960's and early 1970's. These streams were: the failed attempts by myself and others to understand the connection between the electron and the muon, the development of electron-positron storage rings, and the development of the theory of sequential leptons. In this paper I give the history of the discovery of the tau and the measurement of its major properties-the properties which established the tau as a sequential lepton

  20. Discovery stories in the science classroom

    Science.gov (United States)

    Arya, Diana Jaleh

    School science has been criticized for its lack of emphasis on the tentative, dynamic nature of science as a process of learning more about our world. This criticism is the guiding force for this present body of work, which focuses on the question: what are the educational benefits for middle school students of reading texts that highlight the process of science in the form of a discovery narrative? This dissertation traces my journey through a review of theoretical perspectives of narrative, an analysis of first-hand accounts of scientific discovery, the complex process of developing age-appropriate, cohesive and engaging science texts for middle school students, and a comparison study (N=209) that seeks to determine the unique benefits of the scientific discovery narrative for the interest in and retained understanding of conceptual information presented in middle school science texts. A total of 209 middle school participants in nine different classrooms from two different schools participated in the experimental study. Each subject read two science texts that differed in topic (the qualities of and uses for radioactive elements and the use of telescopic technology to see planets in space) and genre (the discovery narrative and the "conceptually known exposition" comparison text). The differences between the SDN and CKE versions for each topic were equivalent in all possible ways (initial introduction, overall conceptual accuracy, elements of human interest, coherence and readability level), save for the unique components of the discovery narrative (i.e., love for their work, acknowledgement of the known, identification of the unknown and the explorative or experimental process to discovery). Participants generally chose the discovery narrative version as the more interesting of the two texts. Additional findings from the experimental study suggest that science texts in the form of SDNs elicit greater long-term retention of key conceptual information, especially

  1. The centenary of discovery of radium

    International Nuclear Information System (INIS)

    Mazeron, J.-J.; Gerbaulet, A.

    1998-01-01

    Henri Becquerel presented the discovery of radium by Pierre and Marie Curie at the Paris Academy of Science on 26th December 1898. One century later, radium has been abandoned, mainly for radiation protection difficulties. It is, however, likely that modern techniques of brachytherapy have inherited to those designed for radium sources, and that radium has cured thousands and thousands patients all over the world for about eighty years. The history of discovery and medical use of radium is summarised. (Copyright (c) 1998 Elsevier Science B.V., Amsterdam. All rights reserved.)

  2. Computational neuropharmacology: dynamical approaches in drug discovery.

    Science.gov (United States)

    Aradi, Ildiko; Erdi, Péter

    2006-05-01

    Computational approaches that adopt dynamical models are widely accepted in basic and clinical neuroscience research as indispensable tools with which to understand normal and pathological neuronal mechanisms. Although computer-aided techniques have been used in pharmaceutical research (e.g. in structure- and ligand-based drug design), the power of dynamical models has not yet been exploited in drug discovery. We suggest that dynamical system theory and computational neuroscience--integrated with well-established, conventional molecular and electrophysiological methods--offer a broad perspective in drug discovery and in the search for novel targets and strategies for the treatment of neurological and psychiatric diseases.

  3. From the nucleus discovery to DWBA

    International Nuclear Information System (INIS)

    Fernandez, B.

    2007-01-01

    The author presents a brief review of the main events in the field of nuclear reactions that are acknowledged as milestones because of their importance due to either experimental setting or physical interpretation. It is shown that the pace of discoveries has been strongly dependent on the technical progress in detection means at the beginning of nuclear physics and now is linked to the development of simulation means. The discovery of the neutron, the development of the Geiger counter, the theory of the compound nucleus or the first direct reactions are among these milestones

  4. HUMEDAD CRÍTICA Y REPELENCIA AL AGUA EN ANDISOLES BAJO COBERTURA DE Cupressus lusitanica y Quercus humboldtii EN LA CUENCA DE LA QUEBRADA PIEDRAS BLANCAS (MEDELLÍN, COLOMBIA CRITICAL MOISTURE AND WATER REPELLENCY ON ANDISOLS UNDER Cupressus lusitanica AND Quercus humboldtii COVER IN THE PIEDRAS BLANCAS WATERSHED ( MEDELLÍN, COLOMBIA

    Directory of Open Access Journals (Sweden)

    Bibiana Caballero Mejía

    2007-12-01

    Full Text Available En dos vertientes de la cuenca de la quebrada Piedras Blancas (Medellín, Colombia se estudió la relación humedad - persistencia de la repelencia al agua en la parte superficial de andisoles bajo dos coberturas vegetales: Cupressus lusitanica (ciprés y Quercus humboldtii (roble, en tres posiciones a lo largo de la vertiente de colinas bajas: superior, media e inferior y en dos condiciones de humedad: con la humedad de campo y con la humedad adquirida al equilibrar al aire durante dos días muestras que habían sido secadas a 105 °C. En cada sitio de la vertiente se ubicó una parcela de 6 m x 5 m y en ella se tomaron 60 muestras de suelo en una malla de 1 m x 0,5 m. La persistencia de la repelencia al agua se evaluó con el método del WDPT en muestras tamizadas a 1 mm. Se presentó un alto número de muestras fuertemente repelentes al agua en todas las condiciones de trabajo, siendo mayor la frecuencia en ciprés que en roble. Tanto la repelencia al agua como la humedad presentaron comportamiento diferencial por cobertura y por posición en la vertiente dentro de la misma cobertura. No se pudo establecer una relación consistente entre el contenido de humedad de las muestras y la persistencia de la repelencia al agua que presentaron, así como tampoco se pudo definir una zona de transición de humedad crítica para que se manifestara la repelencia al agua en ellas, en ninguna de las dos coberturas vegetales y en ninguna posición en la vertiente.In two hillside of the Piedras Blancas watershed ( Medellín, Colombia was studied the relation humidity - persistence of the water repellency on the surface of the andisols under two vegetable covers: Cupressus lusitanica (cypress and Quercus humboldtii (oak groves. These were found in three different positions along the side of low hills: upper, middle and lower grounds, as well as in two conditions of humidity: with the humidity acquired when equilibrated with the air during two days (samples

  5. Microscopy Opening Up New Cancer Discovery Avenues

    Science.gov (United States)

    Today’s high-powered microscopes are allowing researchers to study the fine details of individual cells and to peer into cells, opening up new avenues of discovery about the inner workings of cells, including the events that can cause healthy cells to tra

  6. The Discovery of the Double Helix

    CERN Multimedia

    CERN. Geneva

    2011-01-01

    Professor James D. Watson has kindly agreed to make a presentation on the 1953 finding of the Double Helix at the Cavendish Laboratory by Francis Crick and himself. Being one of the greatest scientific discoveries in human history, little else needs to be added.

  7. Discovery and preclinical development of new antibiotics.

    Science.gov (United States)

    Hughes, Diarmaid; Karlén, Anders

    2014-05-01

    Antibiotics are the medical wonder of our age, but an increasing frequency of resistance among key pathogens is rendering them less effective. If this trend continues the consequences for cancer patients, organ transplant patients, and indeed the general community could be disastrous. The problem is complex, involving abuse and overuse of antibiotics (selecting for an increasing frequency of resistant bacteria), together with a lack of investment in discovery and development (resulting in an almost dry drug development pipeline). Remedial approaches to the problem should include taking measures to reduce the selective pressures for resistance development, and taking measures to incentivize renewed investment in antibiotic discovery and development. Bringing new antibiotics to the clinic is critical because this is currently the only realistic therapy that can ensure the level of infection control required for many medical procedures. Here we outline the complex process involved in taking a potential novel antibiotic from the initial discovery of a hit molecule, through lead and candidate drug development, up to its entry into phase I clinical trials. The stringent criteria that a successful drug must meet, balancing high efficacy in vivo against a broad spectrum of pathogens, with minimal liabilities against human targets, explain why even with sufficient investment this process is prone to a high failure rate. This emphasizes the need to create a well-funded antibiotic discovery and development pipeline that can sustain the continuous delivery of novel candidate drugs into clinical trials, to ensure the maintenance of the advanced medical procedures we currently take for granted.

  8. Knowledge discovery in the prediction of bankruptcy

    NARCIS (Netherlands)

    Almeida, R.J.; Vieira, S.M.; Milea, D.V.; Kaymak, U.; Costa Sousa, da J.M.; Carvalho, J.P.; Dubois, D.; Kaymak, U.

    2009-01-01

    Knowledge discovery in databases (KDD) is the process of discovering interesting knowledge from large amounts of data. However, real-world datasets have problems such as incompleteness, redundancy, inconsistency, noise, etc. All these problems affect the performance of data mining algorithms. Thus,

  9. Discovery – Methotrexate: Chemotherapy Treatment for Cancer

    Science.gov (United States)

    Prior to the 1950s, treatment for the majority of cancers was limited to either surgery or the use of radiation. The discovery of the use of methotrexate in curing a rare cancer marked the first time a cancer had been cured. This led to the development of many of today’s common cancer treatments.

  10. 41 CFR 105-70.021 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Discovery. 105-70.021 Section 105-70.021 Public Contracts and Property Management Federal Property Management Regulations System..., papers, and other data and documentary evidence. Nothing contained herein shall be interpreted to require...

  11. 5 CFR 185.122 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Discovery. 185.122 Section 185.122 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES..., answers, records, accounts, papers, and other data and documentary evidence. Nothing contained herein...

  12. (Self-) Discovery Service: Helping Students Help Themselves

    Science.gov (United States)

    Debonis, Rocco; O'Donnell, Edward; Thomes, Cynthia

    2012-01-01

    EBSCO Discovery Service (EDS) has been heavily used by UMUC students since its implementation in fall 2011, but experience has shown that it is not always the most appropriate source for satisfying students' information needs and that they often need assistance in understanding how the tool works and how to use it effectively. UMUC librarians have…

  13. Scientific Discoveries the Year I Was Born

    Science.gov (United States)

    Cherif, Abour

    2012-01-01

    The author has successfully used a learning activity titled "The Year I Was Born" to motivate students to conduct historical research and present key scientific discoveries from their birth year. The activity promotes writing, helps students enhance their scientific literacy, and also improves their attitude toward the learning of science. As one…

  14. Comment on "drug discovery: turning the titanic".

    Science.gov (United States)

    Lesterhuis, W Joost; Bosco, Anthony; Lake, Richard A

    2014-03-26

    The pathobiology-based approach to research and development has been the dominant paradigm for successful drug discovery over the last decades. We propose that the molecular and cellular events that govern a resolving, rather than an evolving, disease may reveal new druggable pathways.

  15. The discovery and development of antiretroviral agents

    NARCIS (Netherlands)

    Lange, Joep M. A.; Ananworanich, Jintanat

    2014-01-01

    Since the discovery of HIV as the causative agent of AIDS in 1983/1984, remarkable progress has been made in finding antiretroviral drugs (ARVs) that are effective against it. A major breakthrough occurred in 1996 when it was found that triple drug therapy (HAART) could durably suppress viral

  16. The discovery of high temperature superconductivity

    International Nuclear Information System (INIS)

    Muller, K. A.; Bednorz, J.G.

    1988-01-01

    This article recalls the different stages which led to the display of high temperature superconductivity for Ba, La, Cu, O and the following avalanche of discoveries for other oxides; the numerous theoretical models which tentatively explain the current experimental results are also reviewed. 30 refs

  17. The discovery of high temperature superconductivity

    International Nuclear Information System (INIS)

    Muller, K.A.; Bednorz, J.G.

    1988-01-01

    This article recalls the different stages which led to the display of high temperature superconductivity for Ba La Cu O, and the following avalanche of discoveries for other oxides; the numerous theoretical models which tentatively explain the current experimental results are also reviewed [fr

  18. Zavoisky and the Discovery of EPR

    Indian Academy of Sciences (India)

    IAS Admin

    moved to Kazan. In 1926, after finishing the nine-year secondary ... year student, he got a patent for an invention. Zavoisky was ... Early Attempts at NMR and Interruption by World War II ... band modulation) and, in some cases, he did not even apply the constant ... was awarded the Lenin Prize for the discovery of EPR. In the.

  19. Secure Service Discovery in Home Networks

    NARCIS (Netherlands)

    Scholten, Johan; van Dijk, H.W.; De Cock, Danny; Preneel, Bart; Kung, Antonio; d'Hooge, Michel

    2006-01-01

    This paper presents an architecture for secure service discovery for use in home networks. We give an overview and rationale of a cluster-based home network architecture that bridges different, often vendor specific, network technologies. We show how it integrates security, communication, and

  20. The next generation of targeted mutation discovery

    NARCIS (Netherlands)

    Harakalova, M.

    2013-01-01

    Sequencing technologies (NGS) now allows efficient analysis of the complete protein-coding regions of genomes (exomes) for multiple samples in a single sequencing run. In Chapter 2, we present our results with a genomic DNA pooling strategy for rare variant discovery on a NGS platform. The high

  1. Pharmacological screening technologies for venom peptide discovery.

    Science.gov (United States)

    Prashanth, Jutty Rajan; Hasaballah, Nojod; Vetter, Irina

    2017-12-01

    Venomous animals occupy one of the most successful evolutionary niches and occur on nearly every continent. They deliver venoms via biting and stinging apparatuses with the aim to rapidly incapacitate prey and deter predators. This has led to the evolution of venom components that act at a number of biological targets - including ion channels, G-protein coupled receptors, transporters and enzymes - with exquisite selectivity and potency, making venom-derived components attractive pharmacological tool compounds and drug leads. In recent years, plate-based pharmacological screening approaches have been introduced to accelerate venom-derived drug discovery. A range of assays are amenable to this purpose, including high-throughput electrophysiology, fluorescence-based functional and binding assays. However, despite these technological advances, the traditional activity-guided fractionation approach is time-consuming and resource-intensive. The combination of screening techniques suitable for miniaturization with sequence-based discovery approaches - supported by advanced proteomics, mass spectrometry, chromatography as well as synthesis and expression techniques - promises to further improve venom peptide discovery. Here, we discuss practical aspects of establishing a pipeline for venom peptide drug discovery with a particular emphasis on pharmacology and pharmacological screening approaches. This article is part of the Special Issue entitled 'Venom-derived Peptides as Pharmacological Tools.' Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. 40 CFR 164.51 - Other discovery.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Other discovery. 164.51 Section 164.51... GOVERNING HEARINGS, UNDER THE FEDERAL INSECTICIDE, FUNGICIDE, AND RODENTICIDE ACT, ARISING FROM REFUSALS TO... OTHER HEARINGS CALLED PURSUANT TO SECTION 6 OF THE ACT General Rules of Practice Concerning Proceedings...

  3. Resource Discovery within the Networked "Hybrid" Library.

    Science.gov (United States)

    Leigh, Sally-Anne

    This paper focuses on the development, adoption, and integration of resource discovery, knowledge management, and/or knowledge sharing interfaces such as interactive portals, and the use of the library's World Wide Web presence to increase the availability and usability of information services. The introduction addresses changes in library…

  4. Introduction to fragment-based drug discovery.

    Science.gov (United States)

    Erlanson, Daniel A

    2012-01-01

    Fragment-based drug discovery (FBDD) has emerged in the past decade as a powerful tool for discovering drug leads. The approach first identifies starting points: very small molecules (fragments) that are about half the size of typical drugs. These fragments are then expanded or linked together to generate drug leads. Although the origins of the technique date back some 30 years, it was only in the mid-1990s that experimental techniques became sufficiently sensitive and rapid for the concept to be become practical. Since that time, the field has exploded: FBDD has played a role in discovery of at least 18 drugs that have entered the clinic, and practitioners of FBDD can be found throughout the world in both academia and industry. Literally dozens of reviews have been published on various aspects of FBDD or on the field as a whole, as have three books (Jahnke and Erlanson, Fragment-based approaches in drug discovery, 2006; Zartler and Shapiro, Fragment-based drug discovery: a practical approach, 2008; Kuo, Fragment based drug design: tools, practical approaches, and examples, 2011). However, this chapter will assume that the reader is approaching the field with little prior knowledge. It will introduce some of the key concepts, set the stage for the chapters to follow, and demonstrate how X-ray crystallography plays a central role in fragment identification and advancement.

  5. Conference Abstracts: Translational Science and Drug Discovery ...

    African Journals Online (AJOL)

    ... and Drug Discovery: Impact on Health, Wellness, Environment and Economics" conference, July 27-29th, 2015, at the Hennessy Park Hotel, Ebène Cybercity, Mauritius. The conference was hosted by the Society for Free radical Research Africa and the International Association of Medical and Biomedical Researchers.

  6. Discovery Learning: Zombie, Phoenix, or Elephant?

    Science.gov (United States)

    Bakker, Arthur

    2018-01-01

    Discovery learning continues to be a topic of heated debate. It has been called a zombie, and this special issue raises the question whether it may be a phoenix arising from the ashes to which the topic was burnt. However, in this commentary I propose it is more like an elephant--a huge topic approached by many people who address different…

  7. Translating Genomic Discoveries to Cure Ultrahypermutant ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Translating Genomic Discoveries to Cure Ultrahypermutant Mismatch Repair Deficient Brain Tumours. Malignant brain tumours are the most common cause of death among children with cancer, but there is no known cure. This project will advance research in this important field. Inherited mutations and childhood cancer.

  8. Computer-Assisted Discovery and Proof

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, David H.; Borwein, Jonathan M.

    2007-12-10

    With the advent of powerful, widely-available mathematical software, combined with ever-faster computer hardware, we are approaching a day when both the discovery and proof of mathematical facts can be done in a computer-assisted manner. his article presents several specific examples of this new paradigm in action.

  9. Neutron Stars and the Discovery of Pulsars.

    Science.gov (United States)

    Greenstein, George

    1985-01-01

    Part one recounted the story of the discovery of pulsars and examined the Crab Nebula, supernovae, and neutron stars. This part (experts from the book "Frozen Star") shows how an understanding of the nature of pulsars allowed astronomers to tie these together. (JN)

  10. Rough – Granular Computing knowledge discovery models

    Directory of Open Access Journals (Sweden)

    Mohammed M. Eissa

    2016-11-01

    Full Text Available Medical domain has become one of the most important areas of research in order to richness huge amounts of medical information about the symptoms of diseases and how to distinguish between them to diagnose it correctly. Knowledge discovery models play vital role in refinement and mining of medical indicators to help medical experts to settle treatment decisions. This paper introduces four hybrid Rough – Granular Computing knowledge discovery models based on Rough Sets Theory, Artificial Neural Networks, Genetic Algorithm and Rough Mereology Theory. A comparative analysis of various knowledge discovery models that use different knowledge discovery techniques for data pre-processing, reduction, and data mining supports medical experts to extract the main medical indicators, to reduce the misdiagnosis rates and to improve decision-making for medical diagnosis and treatment. The proposed models utilized two medical datasets: Coronary Heart Disease dataset and Hepatitis C Virus dataset. The main purpose of this paper was to explore and evaluate the proposed models based on Granular Computing methodology for knowledge extraction according to different evaluation criteria for classification of medical datasets. Another purpose is to make enhancement in the frame of KDD processes for supervised learning using Granular Computing methodology.

  11. Social Relationship Discovery Via Call Records

    Directory of Open Access Journals (Sweden)

    Zhao Wen-Zhe

    2017-01-01

    Full Text Available Telecom users constitute a huge, but relatively sparse social network. Community discovery has been a research topic of data mining. Traditional algorithms are greatly influenced by outliers. This paper presents a new algorithm based on social triangle theory. Experiments show that the new algorithm is effective.

  12. Inseparability of science history and discovery

    Directory of Open Access Journals (Sweden)

    J. M. Herndon

    2010-04-01

    Full Text Available Science is very much a logical progression through time. Progressing along a logical path of discovery is rather like following a path through the wilderness. Occasionally the path splits, presenting a choice; the correct logical interpretation leads to further progress, the wrong choice leads to confusion. By considering deeply the relevant science history, one might begin to recognize past faltering in the logical progression of observations and ideas and, perhaps then, to discover new, more precise understanding. The following specific examples of science faltering are described from a historical perspective: (1 Composition of the Earth's inner core; (2 Giant planet internal energy production; (3 Physical impossibility of Earth-core convection and Earth-mantle convection, and; (4 Thermonuclear ignition of stars. For each example, a revised logical progression is described, leading, respectively, to: (1 Understanding the endo-Earth's composition; (2 The concept of nuclear georeactor origin of geo- and planetary magnetic fields; (3 The invalidation and replacement of plate tectonics; and, (4 Understanding the basis for the observed distribution of luminous stars in galaxies. These revised logical progressions clearly show the inseparability of science history and discovery. A different and more fundamental approach to making scientific discoveries than the frequently discussed variants of the scientific method is this: An individual ponders and through tedious efforts arranges seemingly unrelated observations into a logical sequence in the mind so that causal relationships become evident and new understanding emerges, showing the path for new observations, for new experiments, for new theoretical considerations, and for new discoveries. Science history is rich in "seemingly unrelated observations" just waiting to be logically and causally related to reveal new discoveries.

  13. Discovery in a World of Mashups

    Science.gov (United States)

    King, T. A.; Ritschel, B.; Hourcle, J. A.; Moon, I. S.

    2014-12-01

    When the first digital information was stored electronically, discovery of what existed was through file names and the organization of the file system. With the advent of networks, digital information was shared on a wider scale, but discovery remained based on file and folder names. With a growing number of information sources, named based discovery quickly became ineffective. The keyword based search engine was one of the first types of a mashup in the world of Web 1.0. Embedded links from one document to another with prescribed relationships between files and the world of Web 2.0 was formed. Search engines like Google used the links to improve search results and a worldwide mashup was formed. While a vast improvement, the need for semantic (meaning rich) discovery was clear, especially for the discovery of scientific data. In response, every science discipline defined schemas to describe their type of data. Some core schemas where shared, but most schemas are custom tailored even though they share many common concepts. As with the networking of information sources, science increasingly relies on data from multiple disciplines. So there is a need to bring together multiple sources of semantically rich information. We explore how harvesting, conceptual mapping, facet based search engines, search term promotion, and style sheets can be combined to create the next generation of mashups in the emerging world of Web 3.0. We use NASA's Planetary Data System and NASA's Heliophysics Data Environment to illustrate how to create a multi-discipline mash-up.

  14. Discovery of the neutron (to the fiftieth anniversary of neutron discovery)

    International Nuclear Information System (INIS)

    Pasechnik, M.V.

    1984-01-01

    Development of neutron physics in the USSR for the recent 50 years from the moment of neutron discovery is considered. History of neutron discovery is presented in brief. Neutron properties and fundamental problems of physics: electric dipole neutron moment, neutron β-decay, neutron interaction with nuclei and potential of nucleon interaction not conserving spatial parity are discussed. Main aspects of neutron physics application in power engineering, nuclear technology and other branches of science and technique are set forth

  15. Open Drug Discovery Toolkit (ODDT): a new open-source player in the drug discovery field.

    Science.gov (United States)

    Wójcikowski, Maciej; Zielenkiewicz, Piotr; Siedlecki, Pawel

    2015-01-01

    There has been huge progress in the open cheminformatics field in both methods and software development. Unfortunately, there has been little effort to unite those methods and software into one package. We here describe the Open Drug Discovery Toolkit (ODDT), which aims to fulfill the need for comprehensive and open source drug discovery software. The Open Drug Discovery Toolkit was developed as a free and open source tool for both computer aided drug discovery (CADD) developers and researchers. ODDT reimplements many state-of-the-art methods, such as machine learning scoring functions (RF-Score and NNScore) and wraps other external software to ease the process of developing CADD pipelines. ODDT is an out-of-the-box solution designed to be easily customizable and extensible. Therefore, users are strongly encouraged to extend it and develop new methods. We here present three use cases for ODDT in common tasks in computer-aided drug discovery. Open Drug Discovery Toolkit is released on a permissive 3-clause BSD license for both academic and industrial use. ODDT's source code, additional examples and documentation are available on GitHub (https://github.com/oddt/oddt).

  16. The Discovery of a Class of High-Temperature Superconductors.

    Science.gov (United States)

    Muller, K. Alex; Bednorz, J. Georg

    1987-01-01

    Describes the new class of oxide superconductors, the importance of these materials, and the concepts that led to its discovery. Summarizes the discovery itself and its early confirmation. Discusses the observation of a superconductive glass state in percolative samples. (TW)

  17. History of the discovery of uranium fission by neutrons

    International Nuclear Information System (INIS)

    Simane, C.

    1989-01-01

    The history is briefly described of the discovery of uranium fission by neutrons, based on the texts of original scientific studies, memories or biographies of those who participated in the discovery and of their contemporaries. Obstacles that stood in the way of the discovery are discussed. It is stated that only a few scientists contributed to the discovery of uranium fission. The fission process itself still remains subject of physical research which studies its detailed laws. (Z.M.). 2 tabs., 16 refs

  18. An extended dual search space model of scientific discovery learning

    NARCIS (Netherlands)

    van Joolingen, Wouter; de Jong, Anthonius J.M.

    1997-01-01

    This article describes a theory of scientific discovery learning which is an extension of Klahr and Dunbar''s model of Scientific Discovery as Dual Search (SDDS) model. We present a model capable of describing and understanding scientific discovery learning in complex domains in terms of the SDDS

  19. A Taxonomy of Self-configuring Service Discovery Systems

    NARCIS (Netherlands)

    Sundramoorthy, V.; Hartel, Pieter H.; Scholten, Johan

    2007-01-01

    We analyze the fundamental concepts and issues in service discovery. This analysis places service discovery in the context of distributed systems by describing service discovery as a third generation naming system. We also describe the essential architectures and the functionalities in service

  20. Mass Spectrometry-Based Biomarker Discovery.

    Science.gov (United States)

    Zhou, Weidong; Petricoin, Emanuel F; Longo, Caterina

    2017-01-01

    The discovery of candidate biomarkers within the entire proteome is one of the most important and challenging goals in proteomic research. Mass spectrometry-based proteomics is a modern and promising technology for semiquantitative and qualitative assessment of proteins, enabling protein sequencing and identification with exquisite accuracy and sensitivity. For mass spectrometry analysis, protein extractions from tissues or body fluids and subsequent protein fractionation represent an important and unavoidable step in the workflow for biomarker discovery. Following extraction of proteins, the protein mixture must be digested, reduced, alkylated, and cleaned up prior to mass spectrometry. The aim of our chapter is to provide comprehensible and practical lab procedures for sample digestion, protein fractionation, and subsequent mass spectrometry analysis.

  1. Historical aspects of the discovery of plutonium

    International Nuclear Information System (INIS)

    Clark, David L.

    2016-01-01

    The historical events that led up to the discovery of plutonium and subsequently, how that discovery helped shape the modern period table of the elements, and ushered in a new era of nuclear science and technology are discussed. When the first of the transuranium elements, neptunium was discovered, it was realized that the radioactive βdecay of "2"3"9Np should lead to the formation of element 94. The scale of the experiments at that time, however, precluded its identification. Plutonium was first produced late in 1940 by Seaborg, McMillan, Kennedy, and Wahl1,2 by bombarding uranium with deuterons to produce the isotope "2"3"8Pu

  2. Panorama 2014 - New oil and gas discoveries

    International Nuclear Information System (INIS)

    Vially, Roland; Hureau, Geoffroy

    2013-12-01

    Spending on exploration increased significantly in 2012, and this growth should continue into 2013. Over a period of ten years, exploration budgets have increased five-fold, leading to major discoveries in regions as yet unexplored. In 2012, 25 billion barrels of oil equivalent (Gboe) were revealed. This is more than the average for the whole decade, but less than the amount for the previous year. Although knowledge of the volumes that have been discovered is still very fragmented, they should continue to fall into 2013. The main reason lies in the fact that spending on exploration is being shifted towards assessing discoveries made in previous years in the particularly prolific basins of Brazil and East Africa, while the exploration of border regions - such as the West African pre-salt formation - is still only in its early stages. (authors)

  3. The discovery of long-term potentiation.

    Science.gov (United States)

    Lømo, Terje

    2003-04-29

    This paper describes circumstances around the discovery of long-term potentiation (LTP). In 1966, I had just begun independent work for the degree of Dr medicinae (PhD) in Per Andersen's laboratory in Oslo after an eighteen-month apprenticeship with him. Studying the effects of activating the perforant path to dentate granule cells in the hippocampus of anaesthetized rabbits, I observed that brief trains of stimuli resulted in increased efficiency of transmission at the perforant path-granule cell synapses that could last for hours. In 1968, Tim Bliss came to Per Andersen's laboratory to learn about the hippocampus and field potential recording for studies of possible memory mechanisms. The two of us then followed up my preliminary results from 1966 and did the experiments that resulted in a paper that is now properly considered to be the basic reference for the discovery of LTP.

  4. Polonium: 110th anniversary of its discovery

    International Nuclear Information System (INIS)

    Mould, R. F.

    2008-01-01

    It is appropriate that the 110 Th anniversary of the discovery of polonium by Marie and Pierre Curie is commemorated in a Polish journal since this element was named for Poland and was also the element discovered by the Curies before they discovered radium. Polonium's discovery and characteristics are described. Polonium has never been used in medicine, and was largely forgotten apart from a few minor industrial uses, and as a trigger for a nuclear weapon, until the murder in November 2006 in London using 210 Polonium, of the ex-KGB officer Alexander Litvinenko. Polonium had previously been linked, without any definite proof, with the deaths of a few scientists who had worked with the element, including Irene and Frederick Joliet-Curie. This review ends with possible evidence for such links. (authors)

  5. Discovery and Selection of Semantic Web Services

    CERN Document Server

    Wang, Xia

    2013-01-01

    For advanced web search engines to be able not only to search for semantically related information dispersed over different web pages, but also for semantic services providing certain functionalities, discovering semantic services is the key issue. Addressing four problems of current solution, this book presents the following contributions. A novel service model independent of semantic service description models is proposed, which clearly defines all elements necessary for service discovery and selection. It takes service selection as its gist and improves efficiency. Corresponding selection algorithms and their implementation as components of the extended Semantically Enabled Service-oriented Architecture in the Web Service Modeling Environment are detailed. Many applications of semantic web services, e.g. discovery, composition and mediation, can benefit from a general approach for building application ontologies. With application ontologies thus built, services are discovered in the same way as with single...

  6. Golden Jubilee photos: A gargantuan discovery

    CERN Multimedia

    2004-01-01

    In July 1973, a groundbreaking discovery was announced in CERN's Main Auditorium: the Gargamelle group had found proof of the weak neutral current. The discovery confirmed the electroweak theory, which had predicted that the weak force and the electromagnetic force were different facets of the same interaction. This paved the way for the Grand Unified Theory, which holds that just after the birth of the Universe all forces were actually the same... Gargamelle, whose "body" now reposes in the Microcosm garden, was a huge bubble chamber weighing around 1000 tonnes, filled with 18 tonnes of liquid freon. Its size, worthy of the giant Gargantua - the son of Gargamelle - was mighty enough to catch neutrinos, the elusive neutral particles which career through space without leaving any tracks. In the photograph, an unseen neutrino interacts with an electron and emerges as a neutrino instead of changing into a muon - what is seen (vertically) is the track of the electron. This lepton event offers p...

  7. Bayesian centroid estimation for motif discovery.

    Science.gov (United States)

    Carvalho, Luis

    2013-01-01

    Biological sequences may contain patterns that signal important biomolecular functions; a classical example is regulation of gene expression by transcription factors that bind to specific patterns in genomic promoter regions. In motif discovery we are given a set of sequences that share a common motif and aim to identify not only the motif composition, but also the binding sites in each sequence of the set. We propose a new centroid estimator that arises from a refined and meaningful loss function for binding site inference. We discuss the main advantages of centroid estimation for motif discovery, including computational convenience, and how its principled derivation offers further insights about the posterior distribution of binding site configurations. We also illustrate, using simulated and real datasets, that the centroid estimator can differ from the traditional maximum a posteriori or maximum likelihood estimators.

  8. Bayesian centroid estimation for motif discovery.

    Directory of Open Access Journals (Sweden)

    Luis Carvalho

    Full Text Available Biological sequences may contain patterns that signal important biomolecular functions; a classical example is regulation of gene expression by transcription factors that bind to specific patterns in genomic promoter regions. In motif discovery we are given a set of sequences that share a common motif and aim to identify not only the motif composition, but also the binding sites in each sequence of the set. We propose a new centroid estimator that arises from a refined and meaningful loss function for binding site inference. We discuss the main advantages of centroid estimation for motif discovery, including computational convenience, and how its principled derivation offers further insights about the posterior distribution of binding site configurations. We also illustrate, using simulated and real datasets, that the centroid estimator can differ from the traditional maximum a posteriori or maximum likelihood estimators.

  9. Bioenergy Knowledge Discovery Framework Fact Sheet

    Energy Technology Data Exchange (ETDEWEB)

    None

    2017-07-01

    The Bioenergy Knowledge Discovery Framework (KDF) supports the development of a sustainable bioenergy industry by providing access to a variety of data sets, publications, and collaboration and mapping tools that support bioenergy research, analysis, and decision making. In the KDF, users can search for information, contribute data, and use the tools and map interface to synthesize, analyze, and visualize information in a spatially integrated manner.

  10. The discovery of the electric current

    Science.gov (United States)

    Cotti, Piero

    1995-02-01

    The first battery, the so called voltaic pile, turns out to be the only and hidden entrance to the world of electrodynamics. It was not until 20 years after Alessandro Volta's discovery that the realisation came that the sensational novelty of the voltaic pile was not the permanent voltage source but the current source. This was not to be expected, and had, therefore, not been searched for specifically, but, rather had been found through a great deal of luck and coincidence in experimentation.

  11. Using Discovery Learning to Encourage Creative Thinking

    OpenAIRE

    Mardia Hi. Rahman

    2017-01-01

    Creative thinking ability development is needed to be implemented by every educator including lecturers to their students. Therefore, they need to seriously act and design their learning process. One of the ways to develop student’s creative thinking is using discovery learning model. This research is conducted in physics education study program in 2016 with students who took learning and teaching class as research subject. From the research analysis result and discussion, it can be concluded...

  12. Financing drug discovery for orphan diseases

    OpenAIRE

    Fagnan, David Erik; Gromatzky, Austin A.; Stein, Roger Mark; Fernandez, Jose-Maria; Lo, Andrew W.

    2014-01-01

    Recently proposed ‘megafund’ financing methods for funding translational medicine and drug development require billions of dollars in capital per megafund to de-risk the drug discovery process enough to issue long-term bonds. Here, we demonstrate that the same financing methods can be applied to orphan drug development but, because of the unique nature of orphan diseases and therapeutics (lower development costs, faster FDA approval times, lower failure rates and lower correlation of failures...

  13. The discovery of the top quark

    International Nuclear Information System (INIS)

    Sinervo, P.K.

    1995-12-01

    The top quark and the Higgs boson are the heaviest elementary particles predicted by the standard model. The four lightest quark flavours, the up, down, strange and charm quarks, were well-established by the mid-1970's. The discovery in 1977 of the Τ resonances, a new family of massive hadrons, required the introduction of the fifth quark flavour. Experimental and theoretical studies have indicated that this quark also has a heavier partner, the top quark

  14. The Discovery of the Top Quark

    Science.gov (United States)

    Sinervo, P.K.

    1995-12-01

    The top quark and the Higgs boson are the heaviest elementary particles predicted by the standard model. The four lightest quark flavours, the up, down, strange and charm quarks, were well-established by the mid-1970's. The discovery in 1977 of the {Tau} resonances, a new family of massive hadrons, required the introduction of the fifth quark flavour. Experimental and theoretical studies have indicated that this quark also has a heavier partner, the top quark.

  15. Discovery of peptidic anti-­myotoxins

    DEFF Research Database (Denmark)

    Bjärtun, Johanna; Laustsen, Andreas Hougaard; Munk, Andreas

    More than 2.5 millions envenomations and 125.000 death occur each year due to snakebite. Current antivenoms consist of immunoglobulinesderived from animals, and they are therefore associated with a high risk of adverse reactions in humans. The use of synthetic peptidic antitoxinsmay lead to safer...... and more effective antivenoms. This research reports the discovery of peptidic antitoxins against myotoxin II from B. asper....

  16. An invertebrate model for CNS drug discovery

    DEFF Research Database (Denmark)

    Al-Qadi, Sonia; Schiøtt, Morten; Hansen, Steen Honoré

    2015-01-01

    BACKGROUND: ABC efflux transporters at the blood brain barrier (BBB), namely the P-glycoprotein (P-gp), restrain the development of central nervous system (CNS) drugs. Consequently, early screening of CNS drug candidates is pivotal to identify those affected by efflux activity. Therefore, simple,...... barriers. CONCLUSION: Findings suggest a conserved mechanism of brain efflux activity between insects and vertebrates, confirming that this model holds promise for inexpensive and high-throughput screening relative to in vivo models, for CNS drug discovery....

  17. New discoveries in Upper and Middle Magdalena

    International Nuclear Information System (INIS)

    Carta Petrolera

    1998-01-01

    In six association contracts and one risk participation contract may give Colombia the possibility of finding new oil reserves. These prospects, located in the Upper and Middle Magdalena Valleys and the Eastern Plains. the completion process, evaluation, confirmation and commercialization should be in the next two years, these new discoveries also reveal interesting geological aspects; some in fractured limestone, similar to the found at Maracaibo lake in Venezuela, where vast oil fields were discovered

  18. Biomimicry as a basis for drug discovery.

    Science.gov (United States)

    Kolb, V M

    1998-01-01

    Selected works are discussed which clearly demonstrate that mimicking various aspects of the process by which natural products evolved is becoming a powerful tool in contemporary drug discovery. Natural products are an established and rich source of drugs. The term "natural product" is often used synonymously with "secondary metabolite." Knowledge of genetics and molecular evolution helps us understand how biosynthesis of many classes of secondary metabolites evolved. One proposed hypothesis is termed "inventive evolution." It invokes duplication of genes, and mutation of the gene copies, among other genetic events. The modified duplicate genes, per se or in conjunction with other genetic events, may give rise to new enzymes, which, in turn, may generate new products, some of which may be selected for. Steps of the inventive evolution can be mimicked in several ways for purpose of drug discovery. For example, libraries of chemical compounds of any imaginable structure may be produced by combinatorial synthesis. Out of these libraries new active compounds can be selected. In another example, genetic system can be manipulated to produce modified natural products ("unnatural natural products"), from which new drugs can be selected. In some instances, similar natural products turn up in species that are not direct descendants of each other. This is presumably due to a horizontal gene transfer. The mechanism of this inter-species gene transfer can be mimicked in therapeutic gene delivery. Mimicking specifics or principles of chemical evolution including experimental and test-tube evolution also provides leads for new drug discovery.

  19. Discovery and History of Amino Acid Fermentation.

    Science.gov (United States)

    Hashimoto, Shin-Ichi

    There has been a strong demand in Japan and East Asia for L-glutamic acid as a seasoning since monosodium glutamate was found to present umami taste in 1907. The discovery of glutamate fermentation by Corynebacterium glutamicum in 1956 enabled abundant and low-cost production of the amino acid, creating a large market. The discovery also prompted researchers to develop fermentative production processes for other L-amino acids, such as lysine. Currently, the amino acid fermentation industry is so huge that more than 5 million metric tons of amino acids are manufactured annually all over the world, and this number continues to grow. Research on amino acid fermentation fostered the notion and skills of metabolic engineering which has been applied for the production of other compounds from renewable resources. The discovery of glutamate fermentation has had revolutionary impacts on both the industry and science. In this chapter, the history and development of glutamate fermentation, including the very early stage of fermentation of other amino acids, are reviewed.

  20. Performance Evaluation of Frequent Subgraph Discovery Techniques

    Directory of Open Access Journals (Sweden)

    Saif Ur Rehman

    2014-01-01

    Full Text Available Due to rapid development of the Internet technology and new scientific advances, the number of applications that model the data as graphs increases, because graphs have highly expressive power to model a complicated structure. Graph mining is a well-explored area of research which is gaining popularity in the data mining community. A graph is a general model to represent data and has been used in many domains such as cheminformatics, web information management system, computer network, and bioinformatics, to name a few. In graph mining the frequent subgraph discovery is a challenging task. Frequent subgraph mining is concerned with discovery of those subgraphs from graph dataset which have frequent or multiple instances within the given graph dataset. In the literature a large number of frequent subgraph mining algorithms have been proposed; these included FSG, AGM, gSpan, CloseGraph, SPIN, Gaston, and Mofa. The objective of this research work is to perform quantitative comparison of the above listed techniques. The performances of these techniques have been evaluated through a number of experiments based on three different state-of-the-art graph datasets. This novel work will provide base for anyone who is working to design a new frequent subgraph discovery technique.

  1. Pathways to new drug discovery in neuropsychiatry

    Directory of Open Access Journals (Sweden)

    Berk Michael

    2012-11-01

    Full Text Available Abstract There is currently a crisis in drug discovery for neuropsychiatric disorders, with a profound, yet unexpected drought in new drug development across the spectrum. In this commentary, the sources of this dilemma and potential avenues to redress the issue are explored. These include a critical review of diagnostic issues and of selection of participants for clinical trials, and the mechanisms for identifying new drugs and new drug targets. Historically, the vast majority of agents have been discovered serendipitously or have been modifications of existing agents. Serendipitous discoveries, based on astute clinical observation or data mining, remain a valid option, as is illustrated by the suggestion in the paper by Wahlqvist and colleagues that treatment with sulfonylurea and metformin reduces the risk of affective disorder. However, the identification of agents targeting disorder-related biomarkers is currently proving particularly fruitful. There is considerable hope for genetics as a purist, pathophysiologically valid pathway to drug discovery; however, it is unclear whether the science is ready to meet this promise. Fruitful paradigms will require a break from the orthodoxy, and creativity and risk may well be the fingerprints of success. See related article http://www.biomedcentral.com/1741-7015/10/150

  2. Systems Pharmacology in Small Molecular Drug Discovery

    Directory of Open Access Journals (Sweden)

    Wei Zhou

    2016-02-01

    Full Text Available Drug discovery is a risky, costly and time-consuming process depending on multidisciplinary methods to create safe and effective medicines. Although considerable progress has been made by high-throughput screening methods in drug design, the cost of developing contemporary approved drugs did not match that in the past decade. The major reason is the late-stage clinical failures in Phases II and III because of the complicated interactions between drug-specific, human body and environmental aspects affecting the safety and efficacy of a drug. There is a growing hope that systems-level consideration may provide a new perspective to overcome such current difficulties of drug discovery and development. The systems pharmacology method emerged as a holistic approach and has attracted more and more attention recently. The applications of systems pharmacology not only provide the pharmacodynamic evaluation and target identification of drug molecules, but also give a systems-level of understanding the interaction mechanism between drugs and complex disease. Therefore, the present review is an attempt to introduce how holistic systems pharmacology that integrated in silico ADME/T (i.e., absorption, distribution, metabolism, excretion and toxicity, target fishing and network pharmacology facilitates the discovery of small molecular drugs at the system level.

  3. A Technique Socratic Questioning-Guided Discovery

    Directory of Open Access Journals (Sweden)

    M. Hakan Türkçapar

    2012-03-01

    Full Text Available “Socratic Method” is a way of teaching philosophical thinking and knowledge by asking questions which was used by antique period greek philosopher Socrates. Socrates was teaching knowledge to his followers by asking questions and the conversation between them was named “Socratic Dialogues”. In this meaning, no novel knowledge is taught to the individual but only what is formerly known is reminded and rediscovered. The form of socratic questioning which is used during the process of cognitive behavioral therapy is known as Guided Discovery. In this method it is aimed to make the client notice the piece of knowledge which he could notice but is not aware with a series of questions. Socratic method or guided discovery consists of several steps which are: Identifying the problem by listening to the client and making reflections, finding alternatives by examining and evaluating, reidentification by using the newly found information and questioning the old distorted belief and reaching to a conclusion and applying it. Question types used during these procedures are, questions for gaining information, questions revealing the meanings, questions revealing the beliefs, questions about behaviours during the similar past experiences, analyse questions and analytic synthesis questions. In order to make the patient feel understood it is important to be empathetic and summarising the problem during the interview. In this text, steps of Socratic Questioning-Guided Discovery will be reviewed with sample dialogues after each step

  4. Discovery radiomics via evolutionary deep radiomic sequencer discovery for pathologically proven lung cancer detection.

    Science.gov (United States)

    Shafiee, Mohammad Javad; Chung, Audrey G; Khalvati, Farzad; Haider, Masoom A; Wong, Alexander

    2017-10-01

    While lung cancer is the second most diagnosed form of cancer in men and women, a sufficiently early diagnosis can be pivotal in patient survival rates. Imaging-based, or radiomics-driven, detection methods have been developed to aid diagnosticians, but largely rely on hand-crafted features that may not fully encapsulate the differences between cancerous and healthy tissue. Recently, the concept of discovery radiomics was introduced, where custom abstract features are discovered from readily available imaging data. We propose an evolutionary deep radiomic sequencer discovery approach based on evolutionary deep intelligence. Motivated by patient privacy concerns and the idea of operational artificial intelligence, the evolutionary deep radiomic sequencer discovery approach organically evolves increasingly more efficient deep radiomic sequencers that produce significantly more compact yet similarly descriptive radiomic sequences over multiple generations. As a result, this framework improves operational efficiency and enables diagnosis to be run locally at the radiologist's computer while maintaining detection accuracy. We evaluated the evolved deep radiomic sequencer (EDRS) discovered via the proposed evolutionary deep radiomic sequencer discovery framework against state-of-the-art radiomics-driven and discovery radiomics methods using clinical lung CT data with pathologically proven diagnostic data from the LIDC-IDRI dataset. The EDRS shows improved sensitivity (93.42%), specificity (82.39%), and diagnostic accuracy (88.78%) relative to previous radiomics approaches.

  5. Scientific Discoveries: What Is Required for Lasting Impact.

    Science.gov (United States)

    Lømo, Terje

    2016-01-01

    I have been involved in two scientific discoveries of some impact. One is the discovery of long-term potentiation (LTP), the phenomenon that brief, high-frequency impulse activity at synapses in the brain can lead to long-lasting increases in their efficiency of transmission. This finding demonstrated that synapses are plastic, a property thought to be necessary for learning and memory. The other discovery is that nerve-evoked muscle impulse activity, rather than putative trophic factors, controls the properties of muscle fibers. Here I describe how these two discoveries were made, the unexpected difficulties of reproducing the first discovery, and the controversies that followed the second discovery. I discuss why the first discovery took many years to become generally recognized, whereas the second caused an immediate sensation and entered textbooks and major reviews but is now largely forgotten. In the long run, discovering a new phenomenon has greater impact than falsifying a popular hypothesis.

  6. Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery

    Directory of Open Access Journals (Sweden)

    Nicholas Ekow Thomford

    2018-05-01

    Full Text Available The therapeutic properties of plants have been recognised since time immemorial. Many pathological conditions have been treated using plant-derived medicines. These medicines are used as concoctions or concentrated plant extracts without isolation of active compounds. Modern medicine however, requires the isolation and purification of one or two active compounds. There are however a lot of global health challenges with diseases such as cancer, degenerative diseases, HIV/AIDS and diabetes, of which modern medicine is struggling to provide cures. Many times the isolation of “active compound” has made the compound ineffective. Drug discovery is a multidimensional problem requiring several parameters of both natural and synthetic compounds such as safety, pharmacokinetics and efficacy to be evaluated during drug candidate selection. The advent of latest technologies that enhance drug design hypotheses such as Artificial Intelligence, the use of ‘organ-on chip’ and microfluidics technologies, means that automation has become part of drug discovery. This has resulted in increased speed in drug discovery and evaluation of the safety, pharmacokinetics and efficacy of candidate compounds whilst allowing novel ways of drug design and synthesis based on natural compounds. Recent advances in analytical and computational techniques have opened new avenues to process complex natural products and to use their structures to derive new and innovative drugs. Indeed, we are in the era of computational molecular design, as applied to natural products. Predictive computational softwares have contributed to the discovery of molecular targets of natural products and their derivatives. In future the use of quantum computing, computational softwares and databases in modelling molecular interactions and predicting features and parameters needed for drug development, such as pharmacokinetic and pharmacodynamics, will result in few false positive leads in drug

  7. Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery.

    Science.gov (United States)

    Thomford, Nicholas Ekow; Senthebane, Dimakatso Alice; Rowe, Arielle; Munro, Daniella; Seele, Palesa; Maroyi, Alfred; Dzobo, Kevin

    2018-05-25

    The therapeutic properties of plants have been recognised since time immemorial. Many pathological conditions have been treated using plant-derived medicines. These medicines are used as concoctions or concentrated plant extracts without isolation of active compounds. Modern medicine however, requires the isolation and purification of one or two active compounds. There are however a lot of global health challenges with diseases such as cancer, degenerative diseases, HIV/AIDS and diabetes, of which modern medicine is struggling to provide cures. Many times the isolation of "active compound" has made the compound ineffective. Drug discovery is a multidimensional problem requiring several parameters of both natural and synthetic compounds such as safety, pharmacokinetics and efficacy to be evaluated during drug candidate selection. The advent of latest technologies that enhance drug design hypotheses such as Artificial Intelligence, the use of 'organ-on chip' and microfluidics technologies, means that automation has become part of drug discovery. This has resulted in increased speed in drug discovery and evaluation of the safety, pharmacokinetics and efficacy of candidate compounds whilst allowing novel ways of drug design and synthesis based on natural compounds. Recent advances in analytical and computational techniques have opened new avenues to process complex natural products and to use their structures to derive new and innovative drugs. Indeed, we are in the era of computational molecular design, as applied to natural products. Predictive computational softwares have contributed to the discovery of molecular targets of natural products and their derivatives. In future the use of quantum computing, computational softwares and databases in modelling molecular interactions and predicting features and parameters needed for drug development, such as pharmacokinetic and pharmacodynamics, will result in few false positive leads in drug development. This review

  8. Controlling the Rate of GWAS False Discoveries.

    Science.gov (United States)

    Brzyski, Damian; Peterson, Christine B; Sobczyk, Piotr; Candès, Emmanuel J; Bogdan, Malgorzata; Sabatti, Chiara

    2017-01-01

    With the rise of both the number and the complexity of traits of interest, control of the false discovery rate (FDR) in genetic association studies has become an increasingly appealing and accepted target for multiple comparison adjustment. While a number of robust FDR-controlling strategies exist, the nature of this error rate is intimately tied to the precise way in which discoveries are counted, and the performance of FDR-controlling procedures is satisfactory only if there is a one-to-one correspondence between what scientists describe as unique discoveries and the number of rejected hypotheses. The presence of linkage disequilibrium between markers in genome-wide association studies (GWAS) often leads researchers to consider the signal associated to multiple neighboring SNPs as indicating the existence of a single genomic locus with possible influence on the phenotype. This a posteriori aggregation of rejected hypotheses results in inflation of the relevant FDR. We propose a novel approach to FDR control that is based on prescreening to identify the level of resolution of distinct hypotheses. We show how FDR-controlling strategies can be adapted to account for this initial selection both with theoretical results and simulations that mimic the dependence structure to be expected in GWAS. We demonstrate that our approach is versatile and useful when the data are analyzed using both tests based on single markers and multiple regression. We provide an R package that allows practitioners to apply our procedure on standard GWAS format data, and illustrate its performance on lipid traits in the North Finland Birth Cohort 66 cohort study. Copyright © 2017 by the Genetics Society of America.

  9. The discovery of X-rays

    International Nuclear Information System (INIS)

    Farmelo, G.

    1995-01-01

    This paper relates the discovery of X-rays by Wilhelm Roentgen in november 1895 and the successive experiments carried out by the German searcher to try to identify the origin of the X radiations. Part of his biography is described, his curriculum at the university, his first experiments with cathodic rays, the first human body radiography and the radiography of various materials. In 1901, Roentgen received the first Nobel price just after being promoted to the rank of professor at the University of Munchen. (J.S.). 2 photos

  10. Advances in knowledge discovery in databases

    CERN Document Server

    Adhikari, Animesh

    2015-01-01

    This book presents recent advances in Knowledge discovery in databases (KDD) with a focus on the areas of market basket database, time-stamped databases and multiple related databases. Various interesting and intelligent algorithms are reported on data mining tasks. A large number of association measures are presented, which play significant roles in decision support applications. This book presents, discusses and contrasts new developments in mining time-stamped data, time-based data analyses, the identification of temporal patterns, the mining of multiple related databases, as well as local patterns analysis.  

  11. Big Data for cardiology: novel discovery?

    Science.gov (United States)

    Mayer-Schönberger, Viktor

    2016-03-21

    Big Data promises to change cardiology through a massive increase in the data gathered and analysed; but its impact goes beyond improving incrementally existing methods. The potential of comprehensive data sets for scientific discovery is examined, and its impact on the scientific method generally and cardiology in particular is posited, together with likely consequences for research and practice. Big Data in cardiology changes how new insights are being discovered. For it to flourish, significant modifications in the methods, structures, and institutions of the profession are necessary. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.

  12. Solar System Moons Discovery and Mythology

    CERN Document Server

    Blunck, Jürgen

    2010-01-01

    Starting from Mars outward this concise handbook provides thorough information on the satellites of the planets in the solar system. Each chapter begins with a section on the discovery and the naming of the planet's satellites or rings. This is followed by a section presenting the historic sources of those names. The book contains tables with the orbital and physical parameters of all satellites and is illustrated throughout with modern photos of the planets and their moons as well as historical and mythological drawings. The Cyrillic transcriptions of the satellite names are provided in a register. Readers interested in the history of astronomy and its mythological backgrounds will enjoy this beautiful volume.

  13. Pulsed laser deposition—invention or discovery?

    International Nuclear Information System (INIS)

    Venkatesan, T

    2014-01-01

    The evolution of pulsed laser deposition had been an exciting process of invention and discovery, with the development of high T c superconducting films as the main driver. It has become the method of choice in research and development for rapid prototyping of multicomponent inorganic materials for preparing a variety of thin films, heterostructures and atomically sharp interfaces, and has become an indispensable tool for advancing oxide electronics. In this paper I will give a personal account of the invention and development of this process at Bellcore/Rutgers, the opportunity, challenges and mostly the extraordinary excitement that was generated, typical of any disruptive technology. (paper)

  14. Oncology drug discovery: planning a turnaround.

    Science.gov (United States)

    Toniatti, Carlo; Jones, Philip; Graham, Hilary; Pagliara, Bruno; Draetta, Giulio

    2014-04-01

    We have made remarkable progress in our understanding of the pathophysiology of cancer. This improved understanding has resulted in increasingly effective targeted therapies that are better tolerated than conventional cytotoxic agents and even curative in some patients. Unfortunately, the success rate of drug approval has been limited, and therapeutic improvements have been marginal, with too few exceptions. In this article, we review the current approach to oncology drug discovery and development, identify areas in need of improvement, and propose strategies to improve patient outcomes. We also suggest future directions that may improve the quality of preclinical and early clinical drug evaluation, which could lead to higher approval rates of anticancer drugs.

  15. 60 years of CERN experiments and discoveries

    CERN Document Server

    Di Lella, Luigi

    2015-01-01

    The book contains a description of the most important experimental results achieved at CERN during the past 60 years, from the mid-1950s to the latest discovery of the Higgs particle. It covers the results from early accelerators at CERN to the most recent results at the LHC and thus provides an excellent review of the achievements of this outstanding laboratory. It reflects not only the impressive scientific progress achieved during the past six decades but demonstrates also the special way of successful international collaboration developed at CERN.

  16. Pulsar discovery by global volunteer computing.

    Science.gov (United States)

    Knispel, B; Allen, B; Cordes, J M; Deneva, J S; Anderson, D; Aulbert, C; Bhat, N D R; Bock, O; Bogdanov, S; Brazier, A; Camilo, F; Champion, D J; Chatterjee, S; Crawford, F; Demorest, P B; Fehrmann, H; Freire, P C C; Gonzalez, M E; Hammer, D; Hessels, J W T; Jenet, F A; Kasian, L; Kaspi, V M; Kramer, M; Lazarus, P; van Leeuwen, J; Lorimer, D R; Lyne, A G; Machenschalk, B; McLaughlin, M A; Messenger, C; Nice, D J; Papa, M A; Pletsch, H J; Prix, R; Ransom, S M; Siemens, X; Stairs, I H; Stappers, B W; Stovall, K; Venkataraman, A

    2010-09-10

    Einstein@Home aggregates the computer power of hundreds of thousands of volunteers from 192 countries to mine large data sets. It has now found a 40.8-hertz isolated pulsar in radio survey data from the Arecibo Observatory taken in February 2007. Additional timing observations indicate that this pulsar is likely a disrupted recycled pulsar. PSR J2007+2722's pulse profile is remarkably wide with emission over almost the entire spin period; the pulsar likely has closely aligned magnetic and spin axes. The massive computing power provided by volunteers should enable many more such discoveries.

  17. Discovery of convoys in trajectory databases

    DEFF Research Database (Denmark)

    Jeung, Hoyoung; Yiu, Man Lung; Zhou, Xiaofang

    2008-01-01

    a group of objects that have traveled together for some time. More specifically, this paper formalizes the concept of a convoy query using density-based notions, in order to capture groups of arbitrary extents and shapes. Convoy discovery is relevant for real-life applications in throughput planning...... convoys are further processed to obtain the actual convoys. Our comprehensive empirical study offers insight into the properties of the paper's proposals and demonstrates that the proposals are effective and efficient on real-world trajectory data....

  18. The in silico drug discovery toolbox: applications in lead discovery and optimization.

    Science.gov (United States)

    Bruno, Agostino; Costantino, Gabriele; Sartori, Luca; Radi, Marco

    2017-11-06

    Discovery and development of a new drug is a long lasting and expensive journey that takes around 15 years from starting idea to approval and marketing of new medication. Despite the R&D expenditures have been constantly increasing in the last few years, number of new drugs introduced into market has been steadily declining. This is mainly due to preclinical and clinical safety issues, which still represent about 40% of drug discontinuation. From this point of view, it is clear that if we want to increase drug-discovery success rate and reduce costs associated with development of a new drug, a comprehensive evaluation/prediction of potential safety issues should be conducted as soon as possible during early drug discovery phase. In the present review, we will analyse the early steps of drug-discovery pipeline, describing the sequence of steps from disease selection to lead optimization and focusing on the most common in silico tools used to assess attrition risks and build a mitigation plan. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  19. Discovery of a New Nearby Star

    Science.gov (United States)

    Teegarden, B. J.; Pravdo, S. H.; Covey, K.; Frazier, O.; Hawley, S. L.; Hicks, M.; Lawrence, K.; McGlynn, T.; Reid, I. N.; Shaklan, S. B.

    2003-01-01

    We report the discovery of a nearby star with a very large proper motion of 5.06 +/- 0.03 arcsec/yr. The star is called SO025300.5+165258 and referred to herein as HPMS (high proper motion star). The discovery came as a result of a search of the SkyMorph database, a sensitive and persistent survey that is well suited for finding stars with high proper motions. There are currently only 7 known stars with proper motions greater than 5 arcsec/yr. We have determined a preliminary value for the parallax of pi = 0.43 +/- 0.13 arcsec. If this value holds our new star ranks behind only the Alpha Centauri system (including Proxima Centauri) and Barnard's star in the list of our nearest stellar neighbours. The spectrum and measured tangential velocity indicate that HPMS is a main-sequence star with spectral type M6.5. However, if our distance measurement is correct, the HPMS is underluminous by 1.2 +/- 0.7 mag.

  20. Discovery Mondays: crystals and particles for medicine

    CERN Multimedia

    2003-01-01

    Question: what are as heavy as lead, as clear as glass, and appear as tiny specks in a doctor's scanner but large as life in a physicist's detector? Answer: the crystals you will be able to observe in all their facets on 1 September at the start of a new season of Discovery Mondays at Microcosm. Come along and meet the CERN physicists who use crystals not only in their detectors but also in the latest generation of scanners. Four workshops will be organised, each devoted to a different medical imaging technique. The first workshop will be run by a physicist from the Crystal Clear collaboration, who will present her collaboration's special breed of crystals, which emit light when they are traversed by high-energy particles, and explain to you these crystals' role in Positron Emission Tomographs. The second workshop will focus on an imaging technique known as the Compton Camera, also based on scintillating crystals. Crystals worth looking at and admiring. Come to the next Discovery Monday to find out how they ...

  1. Scientists Like Me: Faces of Discovery

    Science.gov (United States)

    Enevoldsen, A. A. G.; Culp, S.; Trinh, A.

    2010-08-01

    During the International Year of Astronomy, Pacific Science Center is hosting a photography exhibit: Scientists Like Me: Faces of Discovery. The exhibit contains photographs of real, current astronomers and scientists working in astronomy and aerospace-related fields from many races, genders, cultural affiliations and walks of life. The photographs were taken and posters designed by Alyssa Trinh and Sarah Culp, high school interns in Discovery Corps, Pacific Science Center's youth development program. The direct contact between the scientists and the interns helps the intended audience of teachers and families personally connect with scientists. The finished posters from this exhibit are available online (http://pacificsciencecenter.org/scientists) for teachers to use in their classrooms, in addition to being displayed at Pacific Science Center and becoming part of Pacific Science Center's permanent art rotation. The objective of this project was to fill a need for representative photographs of scientists in the world community. It also met two of the goals of International Year of Astronomy: to provide a modern image of science and scientists, and to improve the gender-balanced representation of scientists at all levels and promote greater involvement by all people in scientific and engineering careers. We would like to build on the success of this project and create an annual summer internship, with different interns, focusing on creating posters for different fields of science.

  2. Discovery and progress of direct cardiac reprogramming.

    Science.gov (United States)

    Kojima, Hidenori; Ieda, Masaki

    2017-06-01

    Cardiac disease remains a major cause of death worldwide. Direct cardiac reprogramming has emerged as a promising approach for cardiac regenerative therapy. After the discovery of MyoD, a master regulator for skeletal muscle, other single cardiac reprogramming factors (master regulators) have been sought. Discovery of cardiac reprogramming factors was inspired by the finding that multiple, but not single, transcription factors were needed to generate induced pluripotent stem cells (iPSCs) from fibroblasts. We first reported a combination of cardiac-specific transcription factors, Gata4, Mef2c, and Tbx5 (GMT), that could convert mouse fibroblasts into cardiomyocyte-like cells, which were designated as induced cardiomyocyte-like cells (iCMs). Following our first report of cardiac reprogramming, many researchers, including ourselves, demonstrated an improvement in cardiac reprogramming efficiency, in vivo direct cardiac reprogramming for heart regeneration, and cardiac reprogramming in human cells. However, cardiac reprogramming in human cells and adult fibroblasts remains inefficient, and further efforts are needed. We believe that future research elucidating epigenetic barriers and molecular mechanisms of direct cardiac reprogramming will improve the reprogramming efficiency, and that this new technology has great potential for clinical applications.

  3. Discovery Mondays - The detectors: tracking particles

    CERN Multimedia

    2005-01-01

    View of a module from the LHCb vertex detector, which will be presented at the next Discovery Monday. How do you observe the invisible? In order to deepen still further our knowledge of the infinitely small, physicists accelerate beams of particles and generate collisions between them at extraordinary energies. The collisions give birth to showers of new particles. What are they? In order to find out, physicists slip into the role of detectives thanks to the detectors. At the next Discovery Monday you will find out about the different methods used at CERN to detect particles. A cloud chamber will allow you to see the tracks of cosmic particles live. You will also be given the chance to see real modules for the ATLAS and for the LHCb experiments. Strange materials will be on hand, such as crystals that are heavier than iron and yet as transparent as glass... Come to the Microcosm and become a top detective yourself! This event will take place in French. Join us at the Microcosm (Reception Building 33, M...

  4. Centenary of the discovery of superconductivity

    CERN Multimedia

    Anaïs Vernède

    2011-01-01

    To mark the centenary of the discovery of the phenomenon of superconductivity, MANEP and the University of Geneva are organising open days at the PhysiScope between 8 and 15 April 2011. On 13 April CERN will make a contribution to the series of events with a lecture on superconductivity followed by a demonstration of the phenomenon at the Globe   Historic graph showing the superconducting transition of mercury, measured in Leiden in 1911 by H. Kamerlingh Onnes. On 8 April 2011 it will be a hundred years since the discovery of superconductivity by the Dutch physicist Kamerlingh Onnes. To mark the occasion, the University of Geneva and MANEP are organising a week-long interactive workshop at the PhysiScope. “The purpose of this initiative is to introduce the general public to this spectacular phenomenon by giving them an opportunity to take part in entertaining experiments”, explains Adriana Aleman, Head of Communications of the University of Geneva. As its contribution to the e...

  5. The Southern HII Region Discovery Survey

    Science.gov (United States)

    Wenger, Trey; Miller Dickey, John; Jordan, Christopher; Bania, Thomas M.; Balser, Dana S.; Dawson, Joanne; Anderson, Loren D.; Armentrout, William P.; McClure-Griffiths, Naomi

    2016-01-01

    HII regions are zones of ionized gas surrounding recently formed high-mass (OB-type) stars. They are among the brightest objects in the sky at radio wavelengths. HII regions provide a useful tool in constraining the Galactic morphological structure, chemical structure, and star formation rate. We describe the Southern HII Region Discovery Survey (SHRDS), an Australia Telescope Compact Array (ATCA) survey that discovered ~80 new HII regions (so far) in the Galactic longitude range 230 degrees to 360 degrees. This project is an extension of the Green Bank Telescope HII Region Discovery Survey (GBT HRDS), Arecibo HRDS, and GBT Widefield Infrared Survey Explorer (WISE) HRDS, which together discovered ~800 new HII regions in the Galactic longitude range -20 degrees to 270 degrees. Similar to those surveys, candidate HII regions were chosen from 20 micron emission (from WISE) coincident with 10 micron (WISE) and 20 cm (SGPS) emission. By using the ATCA to detect radio continuum and radio recombination line emission from a subset of these candidates, we have added to the population of known Galactic HII regions.

  6. Discovery Mondays - The detectors: tracking particles

    CERN Multimedia

    2005-01-01

    View of a module from the LHCb vertex detector, which will be presented at the next Discovery Monday. How do you observe the invisible? In order to deepen still further our knowledge of the infinitely small, physicists accelerate beams of particles at close to the speed of light, then generate collisions between them at extraordinary energies, giving birth to showers of new particles. What are these particles? In order to find out, physicists transform themselves into detectives with the help of the detectors. Located around the collision area, these exceptional machines are made up of various layers, each of which detects and measures specific properties of the particles that travel through them. Powerful computers then reconstruct their trajectory and record their charge, mass and energy in order to build up a kind of particle ID card. At the next Discovery Monday you will be able to find out about the different methods used at CERN to detect particles. A cloud chamber will provide live images of the trac...

  7. X-Ray Astronomy Discovery Experiments, III*

    Science.gov (United States)

    Fisher, P. C.

    2011-04-01

    The first paper established the existence of concurrent discovery experiments by Riccardo Giacconi and myself at the start of x-ray astronomy.footnotetextR. Giacconi et al., Phys. Rev. Lett. 9, 439 (1962).^,footnotetextP. C. Fisher et al., Quasars and High Energy Astronomy including Proceedings of the 2^nd Texas Symposium on Relativistic Astrophysics 15 - 19 December 1964 (K. N. Douglas et. al., eds.) Gordon and Breach Science Publishers, New York, p. 253 (1969).^,footnotetextP. C. Fisher, BAPS 53 No. 2, 165 (2008). Paper II footnotetextP.C. Fisher, http://www.aps.org/units/fhp/index.cfm plus FHP link to April 2009 presentation H14.00006. described some acts by some individuals/institutions over four decades that may have caused the illusion that I had not made a discovery. Some additional data about this illusion, and the first possible measurement of x-ray emission from a black hole, will be presented. This paper's primary goal is for the American Physical Society to have Giacconi comment on several questions of a historical nature. [4pt] *Work supported by NASA contracts NAS5-1174 and NASw-909, the Lockheed Independent Research Program, and Ruffner Associates.

  8. Discovery Monday - Behind the plug: communication networks

    CERN Multimedia

    2004-01-01

    Ever wondered what happens to your email when you click "send"? And when you make a phone call, how does your voice travel down the wire? Find out more about communication networks and their applications at the next Discovery Monday in Microcosm on 1 March. At CERN, networks are used for a multitude of reasons. Mobile phones, for example, are used in the laboratory's underground areas. Optical fibre cabling ensures that CERN's computers are connected to the rest of the world. But how do optical fibres work and what does the future have in store? CERN's experiments also need networks. Particle detectors are made of many layers, each relays complex information to a computer analysis centre which reconstitutes the passage of the particles resulting from collisions. Many billions of bytes are transmitted every second from a multitude of sources, to many computers.  No single computer can handle such a huge flow of information. The next Discovery Monday is your chance to find out how this works.  Participate i...

  9. Midwest Lake uranium discovery, Saskatchewan, Canada

    International Nuclear Information System (INIS)

    Scott, F.

    1981-01-01

    The discovery of the Midwest Lake uranium deposit in Saskatchewan came some ten years after the start of exploration. The original mining rights were acquired on the basis of regional published, geology and proximity to the earlier discovery. Aerial radiometric surveys led to the location of a train of radioactive, glacially transported sandstone boulders and cobbles. The source of these mineralized erratics did not outcrop, and an extensive series of magnetic, electromagnetic, seismic and gravity surveys was carried out in an unsuccessful attempt to identify the source location. These surveys were followed by several programmes of diamond drilling, geochemical surveys and Pleistocene geological studies. None of these programmes or surveys encountered bedrock mineralization. When information about ore controls in the Athabasca Basin became available, a limited programme of three 300-m wildcat diamond-drill holes was proposed. The second of these holes cut weak radioactivity in a poorly cored intersection. This intersection was at an unconformity at a depth of 200 m. The programme terminated prematurely with early melting of lake ice. The first hole in the subsequent winter's follow-up drilling intersected uranium values in excess of 8%. (author)

  10. Feedback-Driven Dynamic Invariant Discovery

    Science.gov (United States)

    Zhang, Lingming; Yang, Guowei; Rungta, Neha S.; Person, Suzette; Khurshid, Sarfraz

    2014-01-01

    Program invariants can help software developers identify program properties that must be preserved as the software evolves, however, formulating correct invariants can be challenging. In this work, we introduce iDiscovery, a technique which leverages symbolic execution to improve the quality of dynamically discovered invariants computed by Daikon. Candidate invariants generated by Daikon are synthesized into assertions and instrumented onto the program. The instrumented code is executed symbolically to generate new test cases that are fed back to Daikon to help further re ne the set of candidate invariants. This feedback loop is executed until a x-point is reached. To mitigate the cost of symbolic execution, we present optimizations to prune the symbolic state space and to reduce the complexity of the generated path conditions. We also leverage recent advances in constraint solution reuse techniques to avoid computing results for the same constraints across iterations. Experimental results show that iDiscovery converges to a set of higher quality invariants compared to the initial set of candidate invariants in a small number of iterations.

  11. Business Model Discovery by Technology Entrepreneurs

    Directory of Open Access Journals (Sweden)

    Steven Muegge

    2012-04-01

    Full Text Available Value creation and value capture are central to technology entrepreneurship. The ways in which a particular firm creates and captures value are the foundation of that firm's business model, which is an explanation of how the business delivers value to a set of customers at attractive profits. Despite the deep conceptual link between business models and technology entrepreneurship, little is known about the processes by which technology entrepreneurs produce successful business models. This article makes three contributions to partially address this knowledge gap. First, it argues that business model discovery by technology entrepreneurs can be, and often should be, disciplined by both intention and structure. Second, it provides a tool for disciplined business model discovery that includes an actionable process and a worksheet for describing a business model in a form that is both concise and explicit. Third, it shares preliminary results and lessons learned from six technology entrepreneurs applying a disciplined process to strengthen or reinvent the business models of their own nascent technology businesses.

  12. Panorama 2017 - New conventional oil and gas discoveries

    International Nuclear Information System (INIS)

    Hureau, Geoffroy; Vially, Roland

    2017-01-01

    In 2016, spending on exploration is expected to decline by approximately 35% for the second consecutive year (total exploration-production is down 24%). However, volumes discovered through conventional exploration should only fall by 25% due to several significant discoveries, particularly in Alaska and West Africa. The largest discovery in 2016 was an unconventional Permian shale basin in the United States, which could alone contain as many hydrocarbons as all of the year's conventional discoveries combined

  13. The Dynamic Radio Sky: An Opportunity for Discovery

    Science.gov (United States)

    2010-01-01

    giant pulses from the Crab pulsar , a small number of dedicated radio transient surveys, and the serendipitous discovery of transient radio sources...used in the discovery of over 1800 radio pulsars . In 2003, the Parkes Multibeam Survey had covered the entire Galactic plane visible from Parkes... pulsars , and confirmed the neutron star nature of these sources, dubbed Rotating Radio Transients (RRATs). Since the discovery of the original 11 RRATs

  14. Discovery of the calcium, indium, tin, and platinum isotopes

    International Nuclear Information System (INIS)

    Amos, S.; Gross, J.L.; Thoennessen, M.

    2011-01-01

    Currently, twenty-four calcium, thirty-eight indium, thirty-eight tin, and thirty-nine platinum isotopes have been observed and the discovery of these isotopes is discussed here. For each isotope a brief synopsis of the first refereed publication, including the production and identification method, is presented. - Highlights: Documentation of the discovery of all calcium, indium, tin and platinum isotopes. → Summary of author, journal, year, place and country of discovery for each isotope. → Brief description of discovery history of each isotope.

  15. Price discovery in a continuous-time setting

    DEFF Research Database (Denmark)

    Dias, Gustavo Fruet; Fernandes, Marcelo; Scherrer, Cristina

    We formulate a continuous-time price discovery model in which the price discovery measure varies (stochastically) at daily frequency. We estimate daily measures of price discovery using a kernel-based OLS estimator instead of running separate daily VECM regressions as standard in the literature. We...... show that our estimator is not only consistent, but also outperforms the standard daily VECM in finite samples. We illustrate our theoretical findings by studying the price discovery process of 10 actively traded stocks in the U.S. from 2007 to 2013....

  16. Conceptual Design For Interplanetary Spaceship Discovery

    Science.gov (United States)

    Benton, Mark G.

    2006-01-01

    With the recently revived national interest in Lunar and Mars missions, this design study was undertaken by the author in an attempt to satisfy the long-term space exploration vision of human travel ``to the Moon, Mars, and beyond'' with a single design or family of vehicles. This paper describes a conceptual design for an interplanetary spaceship of the not-to-distant future. It is a design that is outwardly similar to the spaceship Discovery depicted in the novel ``2001 - A Space Odyssey'' and film of the same name. Like its namesake, this spaceship could one day transport a human expedition to explore the moons of Jupiter. This spaceship Discovery is a real engineering design that is capable of being implemented using technologies that are currently at or near the state-of-the-art. The ship's main propulsion and electrical power are provided by bi-modal nuclear thermal rocket engines. Configurations are presented to satisfy four basic Design Reference Missions: (1) a high-energy mission to Jupiter's moon Callisto, (2) a high-energy mission to Mars, (3) a low-energy mission to Mars, and (4) a high-energy mission to the Moon. The spaceship design includes dual, strap-on boosters to enable the high-energy Mars and Jupiter missions. Three conceptual lander designs are presented: (1) Two types of Mars landers that utilize atmospheric and propulsive braking, and (2) a lander for Callisto or Earth's Moon that utilizes only propulsive braking. Spaceship Discovery offers many advantages for human exploration of the Solar System: (1) Nuclear propulsion enables propulsive capture and escape maneuvers at Earth and target planets, eliminating risky aero-capture maneuvers. (2) Strap-on boosters provide robust propulsive energy, enabling flexibility in mission planning, shorter transit times, expanded launch windows, and free-return abort trajectories from Mars. (3) A backup abort propulsion system enables crew aborts at multiple points in the mission. (4) Clustered NTR

  17. Delivering Hubble Discoveries to the Classroom

    Science.gov (United States)

    Eisenhamer, B.; Villard, R.; Weaver, D.; Cordes, K.; Knisely, L.

    2013-04-01

    Today's classrooms are significantly influenced by current news events, delivered instantly into the classroom via the Internet. Educators are challenged daily to transform these events into student learning opportunities. In the case of space science, current news events may be the only chance for educators and students to explore the marvels of the Universe. Inspired by these circumstances, the education and news teams developed the Star Witness News science content reading series. These online news stories (also available in downloadable PDF format) mirror the content of Hubble press releases and are designed for upper elementary and middle school level readers to enjoy. Educators can use Star Witness News stories to reinforce students' reading skills while exposing students to the latest Hubble discoveries.

  18. Using Aptamers for Cancer Biomarker Discovery

    Directory of Open Access Journals (Sweden)

    Yun Min Chang

    2013-01-01

    Full Text Available Aptamers are single-stranded synthetic DNA- or RNA-based oligonucleotides that fold into various shapes to bind to a specific target, which includes proteins, metals, and molecules. Aptamers have high affinity and high specificity that are comparable to that of antibodies. They are obtained using iterative method, called (Systematic Evolution of Ligands by Exponential Enrichment SELEX and cell-based SELEX (cell-SELEX. Aptamers can be paired with recent advances in nanotechnology, microarray, microfluidics, and other technologies for applications in clinical medicine. One particular area that aptamers can shed a light on is biomarker discovery. Biomarkers are important in diagnosis and treatment of cancer. In this paper, we will describe ways in which aptamers can be used to discover biomarkers for cancer diagnosis and therapeutics.

  19. Testing jumps via false discovery rate control.

    Science.gov (United States)

    Yen, Yu-Min

    2013-01-01

    Many recently developed nonparametric jump tests can be viewed as multiple hypothesis testing problems. For such multiple hypothesis tests, it is well known that controlling type I error often makes a large proportion of erroneous rejections, and such situation becomes even worse when the jump occurrence is a rare event. To obtain more reliable results, we aim to control the false discovery rate (FDR), an efficient compound error measure for erroneous rejections in multiple testing problems. We perform the test via the Barndorff-Nielsen and Shephard (BNS) test statistic, and control the FDR with the Benjamini and Hochberg (BH) procedure. We provide asymptotic results for the FDR control. From simulations, we examine relevant theoretical results and demonstrate the advantages of controlling the FDR. The hybrid approach is then applied to empirical analysis on two benchmark stock indices with high frequency data.

  20. Testing jumps via false discovery rate control.

    Directory of Open Access Journals (Sweden)

    Yu-Min Yen

    Full Text Available Many recently developed nonparametric jump tests can be viewed as multiple hypothesis testing problems. For such multiple hypothesis tests, it is well known that controlling type I error often makes a large proportion of erroneous rejections, and such situation becomes even worse when the jump occurrence is a rare event. To obtain more reliable results, we aim to control the false discovery rate (FDR, an efficient compound error measure for erroneous rejections in multiple testing problems. We perform the test via the Barndorff-Nielsen and Shephard (BNS test statistic, and control the FDR with the Benjamini and Hochberg (BH procedure. We provide asymptotic results for the FDR control. From simulations, we examine relevant theoretical results and demonstrate the advantages of controlling the FDR. The hybrid approach is then applied to empirical analysis on two benchmark stock indices with high frequency data.

  1. Genome engineering for microbial natural product discovery.

    Science.gov (United States)

    Choi, Si-Sun; Katsuyama, Yohei; Bai, Linquan; Deng, Zixin; Ohnishi, Yasuo; Kim, Eung-Soo

    2018-03-03

    The discovery and development of microbial natural products (MNPs) have played pivotal roles in the fields of human medicine and its related biotechnology sectors over the past several decades. The post-genomic era has witnessed the development of microbial genome mining approaches to isolate previously unsuspected MNP biosynthetic gene clusters (BGCs) hidden in the genome, followed by various BGC awakening techniques to visualize compound production. Additional microbial genome engineering techniques have allowed higher MNP production titers, which could complement a traditional culture-based MNP chasing approach. Here, we describe recent developments in the MNP research paradigm, including microbial genome mining, NP BGC activation, and NP overproducing cell factory design. Copyright © 2018 Elsevier Ltd. All rights reserved.

  2. The discovery of drug-induced illness.

    Science.gov (United States)

    Jick, H

    1977-03-03

    The increased use of drugs (and the concurrent increased risks of drug-induced illness) require definition of relevant research areas and strategy. For established marketed drugs, research needs depend on the magnitudes of risk of an illness from a drug and the base-line risk. With the drug risk high and the base-line risk low, the problem surfaces in premarketing studies or through the epidemic that develops after marketing. If the drug adds slightly to a high base-line risk, the effect is undetectable. When both risks are low, adverse effects can be discovered by chance, but systematic case-referent studies can speed discovery. If both risks are high, clinical trials and nonexperimental studies may be used. With both risks intermediate, systematic evaluations, especially case-referent studies are needed. Newly marketed drugs should be routinely evaluated through compulsory registration and follow-up study of the earliest users.

  3. Natural Products in the Discovery of Agrochemicals.

    Science.gov (United States)

    Loiseleur, Olivier

    2017-12-01

    Natural products have a long history of being used as, or serving as inspiration for, novel crop protection agents. Many of the discoveries in agrochemical research in the last decades have their origin in a wide range of natural products from a variety of sources. In light of the continuing need for new tools to address an ever-changing array of fungal, weed and insect pests, new agricultural practices and evolving regulatory requirements, the needs for new agrochemical tools remains as critical as ever. In that respect, nature continues to be an important source for novel chemical structures and biological mechanisms to be applied for the development of pest control agents. Here we review several of the natural products and their derivatives which contributed to shape crop protection research in past and present.

  4. Centennial celebration of the discovery of radioactivity

    International Nuclear Information System (INIS)

    Bimbot, R.

    1999-01-01

    Initiated in January 1996 by a ceremony held at the French National Academy of Medicine, the centennial commemoration of the discovery of radioactivity will continue until the end of 1998 when a similar ceremony will take place at the Academy of Sciences. The manifestations are now organized over the whole French territory with the help of 22 regional committees. Educational actions and conferences have been stimulated by the recent edition of the booklet 'Radioactivity' in French, English and Spanish, which has been sent to all the middle and secondary schools in France. A series of international actions are also scheduled in France and abroad, with the help of the French Foreign Affairs Ministry. (authors)

  5. Guided discovery learning in geometry learning

    Science.gov (United States)

    Khasanah, V. N.; Usodo, B.; Subanti, S.

    2018-03-01

    Geometry is a part of the mathematics that must be learned in school. The purpose of this research was to determine the effect of Guided Discovery Learning (GDL) toward geometry learning achievement. This research had conducted at junior high school in Sukoharjo on academic years 2016/2017. Data collection was done based on student’s work test and documentation. Hypothesis testing used two ways analysis of variance (ANOVA) with unequal cells. The results of this research that GDL gave positive effect towards mathematics learning achievement. GDL gave better mathematics learning achievement than direct learning. There was no difference of mathematics learning achievement between male and female. There was no an interaction between sex differences and learning models toward student’s mathematics learning achievement. GDL can be used to improve students’ mathematics learning achievement in geometry.

  6. Gideon Mantell and the Discovery of Dinosaurs

    Science.gov (United States)

    Dean, Dennis R.

    1999-01-01

    Gideon Mantell and the Discovery of Dinosaurs is a scholarly yet accessible biography--the first in a generation--of a pioneering dinosaur hunter and scholar. Gideon Mantell discovered the Iguanodon (a famous tale set right in this book) and several other dinosaur species, spent over twenty-five years restoring Iguanodon fossils, and helped establish the idea of an Age of Reptiles that ended with their extinction at the conclusion of the Mesozoic Era. He had significant interaction with such well-known figures as James Parkinson, Georges Cuvier, Charles Lyell, Roderick Murchison, Charles Darwin, and Richard Owen. Dennis Dean, a well-known scholar of geology and the Victorian era, here places Mantell's career in its cultural context, employing original research in archives throughout the world, including the previously unexamined Mantell family papers in New Zealand.

  7. STS-114: Discovery Launch Readiness Press Conference

    Science.gov (United States)

    2005-01-01

    Michael Griffin, NASA Administrator; Wayne Hale, Space Shuttle Deputy Program Manager; Mike Wetmore, Director of Shuttle Processing; and 1st Lieutenant Mindy Chavez, Launch Weather Officer-United States Air Force 45th Weather Squadron are in attendance for this STS-114 Discovery launch readiness press conference. The discussion begins with Wayne Hale bringing to the table a low level sensor device for everyone to view. He talks in detail about all of the extensive tests that were performed on these sensors and the completion of these ambient tests. Chavez presents her weather forecast for the launch day of July 26th 2005. Michael Griffin and Wayne Hale answer questions from the news media pertaining to the sensors and launch readiness. The video ends with footage of Pilot Jim Kelly and Commander Eileen Collins conducting test flights in a Shuttle Training Aircraft (STA) that simulates Space Shuttle landing.

  8. Financing drug discovery for orphan diseases.

    Science.gov (United States)

    Fagnan, David E; Gromatzky, Austin A; Stein, Roger M; Fernandez, Jose-Maria; Lo, Andrew W

    2014-05-01

    Recently proposed 'megafund' financing methods for funding translational medicine and drug development require billions of dollars in capital per megafund to de-risk the drug discovery process enough to issue long-term bonds. Here, we demonstrate that the same financing methods can be applied to orphan drug development but, because of the unique nature of orphan diseases and therapeutics (lower development costs, faster FDA approval times, lower failure rates and lower correlation of failures among disease targets) the amount of capital needed to de-risk such portfolios is much lower in this field. Numerical simulations suggest that an orphan disease megafund of only US$575 million can yield double-digit expected rates of return with only 10-20 projects in the portfolio. Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.

  9. Discovery Monday: How to measure success

    CERN Multimedia

    2003-01-01

    The last Discovery Monday which was carried out by the surveyors at CERN was a great success, one which they could not measure with their usual precision. The various entertaining as well as instructive experiments deserve a big "Thank you" to the SU group at the EST division. Children learn how to measure with the water level, like in Roman times.At CERN, photogrammetric techniques are used to precisely measure positions of complex ensembles like detectors. In Microcosm, photogrammetry is also invaluable to take the measure of visitors who can no longer cheat about their size. They were measured to a precision of one tenth of a millimetre and received a certificate.The alignment of accelerators is one of the big challenges for the surveyors at CERN. But even with good instruments, you need to have good eyes!

  10. Data Warehouse Discovery Framework: The Foundation

    Science.gov (United States)

    Apanowicz, Cas

    The cost of building an Enterprise Data Warehouse Environment runs usually in millions of dollars and takes years to complete. The cost, as big as it is, is not the primary problem for a given corporation. The risk that all money allocated for planning, design and implementation of the Data Warehouse and Business Intelligence Environment may not bring the result expected, fare out way the cost of entire effort [2,10]. The combination of the two above factors is the main reason that Data Warehouse/Business Intelligence is often single most expensive and most risky IT endeavor for companies [13]. That situation was the main author's inspiration behind founding of Infobright Corp and later on the concept of Data Warehouse Discovery Framework.

  11. Experiences in fragment-based drug discovery.

    Science.gov (United States)

    Murray, Christopher W; Verdonk, Marcel L; Rees, David C

    2012-05-01

    Fragment-based drug discovery (FBDD) has become established in both industry and academia as an alternative approach to high-throughput screening for the generation of chemical leads for drug targets. In FBDD, specialised detection methods are used to identify small chemical compounds (fragments) that bind to the drug target, and structural biology is usually employed to establish their binding mode and to facilitate their optimisation. In this article, we present three recent and successful case histories in FBDD. We then re-examine the key concepts and challenges of FBDD with particular emphasis on recent literature and our own experience from a substantial number of FBDD applications. Our opinion is that careful application of FBDD is living up to its promise of delivering high quality leads with good physical properties and that in future many drug molecules will be derived from fragment-based approaches. Copyright © 2012 Elsevier Ltd. All rights reserved.

  12. Biomarker Gene Signature Discovery Integrating Network Knowledge

    Directory of Open Access Journals (Sweden)

    Holger Fröhlich

    2012-02-01

    Full Text Available Discovery of prognostic and diagnostic biomarker gene signatures for diseases, such as cancer, is seen as a major step towards a better personalized medicine. During the last decade various methods, mainly coming from the machine learning or statistical domain, have been proposed for that purpose. However, one important obstacle for making gene signatures a standard tool in clinical diagnosis is the typical low reproducibility of these signatures combined with the difficulty to achieve a clear biological interpretation. For that purpose in the last years there has been a growing interest in approaches that try to integrate information from molecular interaction networks. Here we review the current state of research in this field by giving an overview about so-far proposed approaches.

  13. [Medicine in the discovery of America].

    Science.gov (United States)

    Gómez-Gallo, Alvaro

    2003-01-01

    The present manuscript aims to record some general aspects of science, and in particular from the beginning of anatomic studies, during the discovery of America. We mention by Vesalio, who was the best known anatomist of his time in the Western world. In addition this establishes the legal origins of the medical profession in Spain and America, with emphasis on distinct treatments, for example, those in Peru and Chile. This manuscript contains anecdotes and accounts of the time, the use of medicines of the day, and the relationship these had with the native medicine. Finally, medical department of Chile is described, together with a mention of the first hospitals of the Republic of Chile.

  14. Discovery Mondays - 'Eureka! Meet the inventors'

    CERN Document Server

    2006-01-01

    Fabio Sauli, the inventor of the GEM detector. Do you imagine an invention as a spontaneous brainchild emergi from the convoluted mind of some scatterbrained and dishevelled scientist? If so, you are mistaken! Join us at Microcosm for the next Discovery Monday at which inventors will be the guests of honour. There you will meet scientists who, thanks to their creativity, have made technological progress possible. By constantly rising to new scientific and technological challenges, CERN has delivered numerous innovations, particularly in the medical field. Members of the Crystal Clear collaboration and the inventor of the GEM detector will give talks about their innovations and their applications, in particular for medical purposes. You will also be able to speak to members of the Medipix collaboration, which is working on improvements to X-ray and gamma ray imaging techniques. The event will be conducted in French. Come to Microcosm, (Reception Building 33, Meyrin site), on Monday 6 February from 7.30 p...

  15. Financing drug discovery via dynamic leverage.

    Science.gov (United States)

    Montazerhodjat, Vahid; Frishkopf, John J; Lo, Andrew W

    2016-03-01

    We extend the megafund concept for funding drug discovery to enable dynamic leverage in which the portfolio of candidate therapeutic assets is predominantly financed initially by equity, and debt is introduced gradually as assets mature and begin generating cash flows. Leverage is adjusted so as to maintain an approximately constant level of default risk throughout the life of the fund. Numerical simulations show that applying dynamic leverage to a small portfolio of orphan drug candidates can boost the return on equity almost twofold compared with securitization with a static capital structure. Dynamic leverage can also add significant value to comparable all-equity-financed portfolios, enhancing the return on equity without jeopardizing debt performance or increasing risk to equity investors. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  16. A metadata initiative for global information discovery

    Science.gov (United States)

    Christian, E.

    2001-01-01

    The Global Information Locator Service (GILS) encompasses a global vision framed by the fundamental values of open societies. Societal values such as a free flow of information impose certain requirements on the society's information infrastructure. These requirements in turn shape the various laws, policies, standards, and technologies that determine the infrastructure design. A particular focus of GILS is the requirement to provide the means for people to discover sources of data and information. Information discovery in the GILS vision is designed to be decentralized yet coherent, and globally comprehensive yet useful for detailed data. This article introduces basic concepts and design issues, with emphasis on the techniques by which GILS supports interoperability. It explains the practical implications of GILS for the common roles of organizations involved in handling information, from content provider through system engineer and intermediary to searcher. The article provides examples of GILS initiatives in various types of communities: bibliographic, geographic, environmental, and government. ?? 2001 Elsevier Science Inc.

  17. Reflections on the discovery of fission

    International Nuclear Information System (INIS)

    Peieris, Rudolf

    1989-01-01

    In this article an eminent scientist looks back on the fifty years since the discovery of nuclear fission. Starting with Enrico Fermi's work with neutrons in the 1930s, the author then introduces Neils Bohr's ideas about atomic structure. The puzzle of what happens when uranium was bombarded by neutrons was gradually unravelled. Finally by 1939 it was becoming realised that the uranium nucleus had split in two. Gradually physicists began to speculate on the possibility of harnessing some of the energy stored in the nucleus and on the idea of a chain reaction. As the end of the decade approached, workers in the field combined with military forces to develop a weapon based on this reaction, the Manhatton Project. The author notes how fast an obscure, esoteric piece of physics research, can be taken up into the military and political area. (UK)

  18. Recent discoveries of Uruguayan Mesozoic vertebrates

    International Nuclear Information System (INIS)

    Soto, M.; Perea, D.; Rinderknetch, A.; Ubilla, M.; Da Silva, J.

    2007-01-01

    Recently, new discoveries of Uruguayan Mesozoic vertebrates have been made, as well as the reinterpretation of already known remains. Its taxonomical and biostratigraphical significance justifies this communication. Concerning the Tacuarembo Formation, on one hand a dipnoan prearticular tooth plate has been reinterpreted as belonging to Ceratodus africanus Haug 1905, a species typical of Late Jurassic-Late Cretaceous deposits of Saharan Africa. This is the second dipnoan taxon recorded in the Tacuarembo Formation, uncovering a previously unrecognized dipnoan diversity in the mid-Mesozoic of South America. On the other hand, a few theropod tooth were confidently identified at the familial level for the first time in our country. The remains include two striated premaxillary tooth crowns, the characters of which, close to Ceratosaurus Marsh 1884, allow to refer them to the family Ceratosauridae, this being the oldest South American record of the family. The striated teeth show strong affinities with those of Late Jurassic ceratosaurids from North America, Iberian Peninsula and Tanzania, which is in accordance with recent proposals about the age of the Lower Member of the Tacuarembo Formation. Concerning the Guichon Formation, we comunicate here in the most important discovery of dinosaur remains in Uruguay. It consist in spatially associated remains from several individuals, including fifty caudal vertebra and several epiphysis, metatarsals and astragali. These materials belong to a titanosaurid sauropod, the characters of which are similar to those of certain Campanian-Maastrichtian titanosaurids. Close to the bones, several eggshell fragments referable to Sphaerovum Mones 1980 - a typical Campanian-Maastrichtian oogenus- were found. This finding represents the first record of sauropod dinosaurs from the Guichon Formation, and suggests a younger age for this unit than early proposed

  19. Synthetic biology for pharmaceutical drug discovery

    Directory of Open Access Journals (Sweden)

    Trosset JY

    2015-12-01

    Full Text Available Jean-Yves Trosset,1 Pablo Carbonell2,3 1Bioinformation Research Laboratory, Sup’Biotech, Villejuif, France; 2Faculty of Life Sciences, SYNBIOCHEM Centre, Manchester Institute of Biotechnology, University of Manchester, Manchester, UK; 3Department of Experimental and Health Sciences (DCEXS, Research Programme on Biomedical Informatics (GRIB, Hospital del Mar Medical Research Institute (IMIM, Universitat Pompeu Fabra (UPF, Barcelona, Spain Abstract: Synthetic biology (SB is an emerging discipline, which is slowly reorienting the field of drug discovery. For thousands of years, living organisms such as plants were the major source of human medicines. The difficulty in resynthesizing natural products, however, often turned pharmaceutical industries away from this rich source for human medicine. More recently, progress on transformation through genetic manipulation of biosynthetic units in microorganisms has opened the possibility of in-depth exploration of the large chemical space of natural products derivatives. Success of SB in drug synthesis culminated with the bioproduction of artemisinin by microorganisms, a tour de force in protein and metabolic engineering. Today, synthetic cells are not only used as biofactories but also used as cell-based screening platforms for both target-based and phenotypic-based approaches. Engineered genetic circuits in synthetic cells are also used to decipher disease mechanisms or drug mechanism of actions and to study cell–cell communication within bacteria consortia. This review presents latest developments of SB in the field of drug discovery, including some challenging issues such as drug resistance and drug toxicity. Keywords: metabolic engineering, plant synthetic biology, natural products, synthetic quorum sensing, drug resistance

  20. Energy-Water Nexus Knowledge Discovery Framework

    Science.gov (United States)

    Bhaduri, B. L.; Foster, I.; Chandola, V.; Chen, B.; Sanyal, J.; Allen, M.; McManamay, R.

    2017-12-01

    As demand for energy grows, the energy sector is experiencing increasing competition for water. With increasing population and changing environmental, socioeconomic scenarios, new technology and investment decisions must be made for optimized and sustainable energy-water resource management. This requires novel scientific insights into the complex interdependencies of energy-water infrastructures across multiple space and time scales. An integrated data driven modeling, analysis, and visualization capability is needed to understand, design, and develop efficient local and regional practices for the energy-water infrastructure components that can be guided with strategic (federal) policy decisions to ensure national energy resilience. To meet this need of the energy-water nexus (EWN) community, an Energy-Water Knowledge Discovery Framework (EWN-KDF) is being proposed to accomplish two objectives: Development of a robust data management and geovisual analytics platform that provides access to disparate and distributed physiographic, critical infrastructure, and socioeconomic data, along with emergent ad-hoc sensor data to provide a powerful toolkit of analysis algorithms and compute resources to empower user-guided data analysis and inquiries; and Demonstration of knowledge generation with selected illustrative use cases for the implications of climate variability for coupled land-water-energy systems through the application of state-of-the art data integration, analysis, and synthesis. Oak Ridge National Laboratory (ORNL), in partnership with Argonne National Laboratory (ANL) and researchers affiliated with the Center for International Earth Science Information Partnership (CIESIN) at Columbia University and State University of New York-Buffalo (SUNY), propose to develop this Energy-Water Knowledge Discovery Framework to generate new, critical insights regarding the complex dynamics of the EWN and its interactions with climate variability and change. An overarching

  1. Peroxidase gene discovery from the horseradish transcriptome.

    Science.gov (United States)

    Näätsaari, Laura; Krainer, Florian W; Schubert, Michael; Glieder, Anton; Thallinger, Gerhard G

    2014-03-24

    Horseradish peroxidases (HRPs) from Armoracia rusticana have long been utilized as reporters in various diagnostic assays and histochemical stainings. Regardless of their increasing importance in the field of life sciences and suggested uses in medical applications, chemical synthesis and other industrial applications, the HRP isoenzymes, their substrate specificities and enzymatic properties are poorly characterized. Due to lacking sequence information of natural isoenzymes and the low levels of HRP expression in heterologous hosts, commercially available HRP is still extracted as a mixture of isoenzymes from the roots of A. rusticana. In this study, a normalized, size-selected A. rusticana transcriptome library was sequenced using 454 Titanium technology. The resulting reads were assembled into 14871 isotigs with an average length of 1133 bp. Sequence databases, ORF finding and ORF characterization were utilized to identify peroxidase genes from the 14871 isotigs generated by de novo assembly. The sequences were manually reviewed and verified with Sanger sequencing of PCR amplified genomic fragments, resulting in the discovery of 28 secretory peroxidases, 23 of them previously unknown. A total of 22 isoenzymes including allelic variants were successfully expressed in Pichia pastoris and showed peroxidase activity with at least one of the substrates tested, thus enabling their development into commercial pure isoenzymes. This study demonstrates that transcriptome sequencing combined with sequence motif search is a powerful concept for the discovery and quick supply of new enzymes and isoenzymes from any plant or other eukaryotic organisms. Identification and manual verification of the sequences of 28 HRP isoenzymes do not only contribute a set of peroxidases for industrial, biological and biomedical applications, but also provide valuable information on the reliability of the approach in identifying and characterizing a large group of isoenzymes.

  2. Beyond discovery: A review of the critique of the discovery view of opportunities

    DEFF Research Database (Denmark)

    Korsgaard, Steffen T.

    This paper systematically reviews and synthesises the critique since 2000 of the discovery view's interpretation of entrepreneurial opportunities. The review shows that the framing of the debate as polarised between two oppositions, the discovery view versus the creation view, is oversimplified....... The issue of whether opportunities are discovered or created is simply one of several key issues in play in the debate. These key issues include questions concerning agency, process, and the role of subjectivity, creativity and interpretation. Propositions for future research are developed from the critique......, emphasising distributed agency, non-linear processes, opportunities as formed, and the role of creativity. However, the paper also points to unresolved issues in relation to all four propositions that require further empirical and conceptual work....

  3. Investigations into Library Web-Scale Discovery Services

    Directory of Open Access Journals (Sweden)

    Jason Vaughan

    2008-03-01

    Full Text Available Web-scale discovery services for libraries provide deep discovery to a library’s local and licensed content, and represent an evolution, perhaps a revolution, for end user information discovery as pertains to library collections.  This article frames the topic of web-scale discovery, and begins by illuminating web-scale discovery from an academic library’s perspective – that is, the internal perspective seeking widespread staff participation in the discovery conversation.  This included the creation of a discovery task force, a group which educated library staff, conducted internal staff surveys, and gathered observations from early adopters.  The article next addresses the substantial research conducted with library vendors which have developed these services.  Such work included drafting of multiple comprehensive question lists distributed to the vendors, onsite vendor visits, and continual tracking of service enhancements.  Together, feedback gained from library staff, insights arrived at by the Discovery Task Force, and information gathered from vendors collectively informed the recommendation of a service for the UNLV Libraries.

  4. Promise Fulfilled? An EBSCO Discovery Service Usability Study

    Science.gov (United States)

    Williams, Sarah C.; Foster, Anita K.

    2011-01-01

    Discovery tools are the next phase of library search systems. Illinois State University's Milner Library implemented EBSCO Discovery Service in August 2010. The authors conducted usability studies on the system in the fall of 2010. The aims of the study were twofold: first, to determine how Milner users set about using the system in order to…

  5. Too New for Textbooks: The Biotechnology Discoveries & Applications Guidebook

    Science.gov (United States)

    Loftin, Madelene; Lamb, Neil E.

    2013-01-01

    The "Biotechnology Discoveries and Applications" guidebook aims to provide teachers with an overview of the recent advances in genetics and biotechnology, allowing them to share these findings with their students. The annual guidebook introduces a wealth of modern genomic discoveries and provides teachers with tools to integrate exciting…

  6. PERSONAL AND CIRCUMSTANTIAL FACTORS INFLUENCING THE ACT OF DISCOVERY.

    Science.gov (United States)

    OSTRANDER, EDWARD R.

    HOW STUDENTS SAY THEY LEARN WAS INVESTIGATED. INTERVIEWS WITH A RANDOM SAMPLE OF 74 WOMEN STUDENTS POSED QUESTIONS ABOUT THE NATURE, FREQUENCY, PATTERNS, AND CIRCUMSTANCES UNDER WHICH ACTS OF DISCOVERY TAKE PLACE IN THE ACADEMIC SETTING. STUDENTS WERE ASSIGNED DISCOVERY RATINGS BASED ON READINGS OF TYPESCRIPTS. EACH STUDENT WAS CLASSIFIED AND…

  7. 19 CFR 210.61 - Discovery and compulsory process.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Discovery and compulsory process. 210.61 Section 210.61 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Temporary Relief § 210.61 Discovery and compulsory...

  8. 19 CFR 210.27 - General provisions governing discovery.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false General provisions governing discovery. 210.27 Section 210.27 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Discovery and Compulsory Process § 210.27 General...

  9. The Discovery of Insulin: A Case Study of Scientific Methodology

    Science.gov (United States)

    Stansfield, William D.

    2012-01-01

    The nature of scientific research sometimes involves a trial-and-error procedure. Popular reviews of successful results from this approach often sanitize the story by omitting unsuccessful trials, thus painting the rosy impression that research simply follows a direct route from hypothesis to experiment to scientific discovery. The discovery of…

  10. Beyond information retrieval: information discovery and multimedia information retrieval

    OpenAIRE

    Roberto Raieli

    2017-01-01

    The paper compares the current methodologies for search and discovery of information and information resources: terminological search and term-based language, own of information retrieval (IR); semantic search and information discovery, being developed mainly through the language of linked data; semiotic search and content-based language, experienced by multimedia information retrieval (MIR).MIR semiotic methodology is, then, detailed.

  11. Delta: the first pion nucleon resonance - its discovery and applications

    International Nuclear Information System (INIS)

    Nagle, D.E.

    1984-07-01

    It is attempted to recapture some of the fun and excitement of the pion-scattering work that led to the discovery of what is now called the delta particle. How significant this discovery was became apparent only gradually. That the delta is alive today and thriving at Los Alamos (as well as other places) is described

  12. Cancer Biomarker Discovery: Lectin-Based Strategies Targeting Glycoproteins

    Directory of Open Access Journals (Sweden)

    David Clark

    2012-01-01

    Full Text Available Biomarker discovery can identify molecular markers in various cancers that can be used for detection, screening, diagnosis, and monitoring of disease progression. Lectin-affinity is a technique that can be used for the enrichment of glycoproteins from a complex sample, facilitating the discovery of novel cancer biomarkers associated with a disease state.

  13. 40 CFR 22.52 - Information exchange and discovery.

    Science.gov (United States)

    2010-07-01

    ... Procedure Act § 22.52 Information exchange and discovery. Respondent's information exchange pursuant to § 22.19(a) shall include information on any economic benefit resulting from any activity or failure to act... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Information exchange and discovery. 22...

  14. Patterns of species discovery in the Western Ghats, a megadiversity ...

    Indian Academy of Sciences (India)

    PRAKASH KUMAR

    Ghats (Flora of Coorg, Flora of Hassan District, Flora of. Udupi, Flora of Tamil Nadu, Flora of Maharashtra, to name a few). Analysis of species discovery curves including four plant and four animal groups indicated a mixed set of patterns. For the charismatic animal species—birds and butterflies—the discovery curve was ...

  15. 10 CFR 2.709 - Discovery against NRC staff.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Discovery against NRC staff. 2.709 Section 2.709 Energy... Rules for Formal Adjudications § 2.709 Discovery against NRC staff. (a)(1) In a proceeding in which the NRC staff is a party, the NRC staff will make available one or more witnesses, designated by the...

  16. Scenario Educational Software: Design and Development of Discovery Learning.

    Science.gov (United States)

    Keegan, Mark

    This book shows how and why the computer is so well suited to producing discovery learning environments. An examination of the literature outlines four basic modes of instruction: didactic, Socratic, inquiry, and discovery. Research from the fields of education, psychology, and physiology is presented to demonstrate the many strengths of…

  17. The rays of life, centennial of discovery of Radium

    International Nuclear Information System (INIS)

    Constantin, Enrique; Plazas, Maria C.

    1999-01-01

    The authors make a recount from the discovery of the rays X for William Conrad Roentgen, in November of 1.985, until our days of the main discoveries and advances in medicine, having like base the radium and their importance in the treatment of the cancer

  18. Price discovery on the Johannesburg Stock Exchange: Examining ...

    African Journals Online (AJOL)

    Price discovery on the Johannesburg Stock Exchange: Examining the impact of the ... of price discovery aim to determine which market reflects new information first. ... This paper examines the FTSE/JSE Top 40 Index, the Top 40 Index Futures ...

  19. Optical Pulsars and Black Arrows: Discoveries as Occasioned Productions

    Science.gov (United States)

    Koschmann, Timothy; Zemel, Alan

    2009-01-01

    The current article represents a methodological proposal. It seeks to address the question of how one might recognize a discovery as a discovery without knowing in advance what is available to be discovered. We propose a solution and demonstrate it using data from a study previously reported by J. Roschelle (1992). Roschelle investigated 2…

  20. DB-XES : enabling process discovery in the large

    NARCIS (Netherlands)

    Syamsiyah, A.; van Dongen, B.F.; van der Aalst, W.M.P.; Ceravolo, P.; Guetl, C.; Rinderle-Ma, S.

    2018-01-01

    Dealing with the abundance of event data is one of the main process discovery challenges. Current process discovery techniques are able to efficiently handle imported event log files that fit in the computer’s memory. Once data files get bigger, scalability quickly drops since the speed required to

  1. Discovery simulations and the assessment of intuitive knowledge

    NARCIS (Netherlands)

    Swaak, Janine; de Jong, Anthonius J.M.

    2001-01-01

    The objective of the present work is to have a closer look at the relations between the features of discovery simulations, the learning processes elicited, the knowledge that results, and the methods used to measure this acquired knowledge. It is argued that discovery simulations are ‘rich’, have a

  2. A Sensitive Assay for Virus Discovery in Respiratory Clinical Samples

    NARCIS (Netherlands)

    de Vries, Michel; Deijs, Martin; Canuti, Marta; van Schaik, Barbera D. C.; Faria, Nuno R.; van de Garde, Martijn D. B.; Jachimowski, Loes C. M.; Jebbink, Maarten F.; Jakobs, Marja; Luyf, Angela C. M.; Coenjaerts, Frank E. J.; Claas, Eric C. J.; Molenkamp, Richard; Koekkoek, Sylvie M.; Lammens, Christine; Leus, Frank; Goossens, Herman; Ieven, Margareta; Baas, Frank; van der Hoek, Lia

    2011-01-01

    In 5-40% of respiratory infections in children, the diagnostics remain negative, suggesting that the patients might be infected with a yet unknown pathogen. Virus discovery cDNA-AFLP (VIDISCA) is a virus discovery method based on recognition of restriction enzyme cleavage sites, ligation of adaptors

  3. Arrayed antibody library technology for therapeutic biologic discovery.

    Science.gov (United States)

    Bentley, Cornelia A; Bazirgan, Omar A; Graziano, James J; Holmes, Evan M; Smider, Vaughn V

    2013-03-15

    Traditional immunization and display antibody discovery methods rely on competitive selection amongst a pool of antibodies to identify a lead. While this approach has led to many successful therapeutic antibodies, targets have been limited to proteins which are easily purified. In addition, selection driven discovery has produced a narrow range of antibody functionalities focused on high affinity antagonism. We review the current progress in developing arrayed protein libraries for screening-based, rather than selection-based, discovery. These single molecule per microtiter well libraries have been screened in multiplex formats against both purified antigens and directly against targets expressed on the cell surface. This facilitates the discovery of antibodies against therapeutically interesting targets (GPCRs, ion channels, and other multispanning membrane proteins) and epitopes that have been considered poorly accessible to conventional discovery methods. Copyright © 2013. Published by Elsevier Inc.

  4. Data mining-aided materials discovery and optimization

    Directory of Open Access Journals (Sweden)

    Wencong Lu

    2017-09-01

    Full Text Available Recent developments in data mining-aided materials discovery and optimization are reviewed in this paper, and an introduction to the materials data mining (MDM process is provided using case studies. Both qualitative and quantitative methods in machine learning can be adopted in the MDM process to accomplish different tasks in materials discovery, design, and optimization. State-of-the-art techniques in data mining-aided materials discovery and optimization are demonstrated by reviewing the controllable synthesis of dendritic Co3O4 superstructures, materials design of layered double hydroxide, battery materials discovery, and thermoelectric materials design. The results of the case studies indicate that MDM is a powerful approach for use in materials discovery and innovation, and will play an important role in the development of the Materials Genome Initiative and Materials Informatics.

  5. Science of the science, drug discovery and artificial neural networks.

    Science.gov (United States)

    Patel, Jigneshkumar

    2013-03-01

    Drug discovery process many times encounters complex problems, which may be difficult to solve by human intelligence. Artificial Neural Networks (ANNs) are one of the Artificial Intelligence (AI) technologies used for solving such complex problems. ANNs are widely used for primary virtual screening of compounds, quantitative structure activity relationship studies, receptor modeling, formulation development, pharmacokinetics and in all other processes involving complex mathematical modeling. Despite having such advanced technologies and enough understanding of biological systems, drug discovery is still a lengthy, expensive, difficult and inefficient process with low rate of new successful therapeutic discovery. In this paper, author has discussed the drug discovery science and ANN from very basic angle, which may be helpful to understand the application of ANN for drug discovery to improve efficiency.

  6. Orphan diseases: state of the drug discovery art.

    Science.gov (United States)

    Volmar, Claude-Henry; Wahlestedt, Claes; Brothers, Shaun P

    2017-06-01

    Since 1983 more than 300 drugs have been developed and approved for orphan diseases. However, considering the development of novel diagnosis tools, the number of rare diseases vastly outpaces therapeutic discovery. Academic centers and nonprofit institutes are now at the forefront of rare disease R&D, partnering with pharmaceutical companies when academic researchers discover novel drugs or targets for specific diseases, thus reducing the failure risk and cost for pharmaceutical companies. Considerable progress has occurred in the art of orphan drug discovery, and a symbiotic relationship now exists between pharmaceutical industry, academia, and philanthropists that provides a useful framework for orphan disease therapeutic discovery. Here, the current state-of-the-art of drug discovery for orphan diseases is reviewed. Current technological approaches and challenges for drug discovery are considered, some of which can present somewhat unique challenges and opportunities in orphan diseases, including the potential for personalized medicine, gene therapy, and phenotypic screening.

  7. Using concepts in literature-based discovery : Simulating Swanson's Raynaud-fish oil and migraine-magnesium discoveries

    NARCIS (Netherlands)

    Weeber, M; Klein, Henny; de Jong-van den Berg, LTW; Vos, R

    Literature-based discovery has resulted in new knowledge. In the biomedical context, Don R. Swanson has generated several literature-based hypotheses that have been corroborated experimentally and clinically. In this paper, we propose a two-step model of the discovery process in which hypotheses are

  8. Discovery Mondays: 'The Grid: a universal computer'

    CERN Multimedia

    2006-01-01

    How can one store and analyse the 15 million billion pieces of data that the LHC will produce each year with a computer that isn't the size of a sky-scraper? The IT experts have found the answer: the Grid, which will harness the power of tens of thousands of computers in the world by putting them together on one network and making them work like a single computer achieving a power that has not yet been matched. The Grid, inspired from the Web, already exists - in fact, several of them exist in the field of science. The European EGEE project, led by CERN, contributes not only to the study of particle physics but to medical research as well, notably in the study of malaria and avian flu. The next Discovery Monday invites you to explore this futuristic computing technology. The 'Grid Masters' of CERN have prepared lively animations to help you understand how the Grid works. Children can practice saving the planet on the Grid video game. You will also discover other applications such as UNOSAT, a United Nations...

  9. Discovery of Allostery in PKA Signaling.

    Science.gov (United States)

    Zhang, Ping; Kornev, Alexandr P; Wu, Jian; Taylor, Susan S

    2015-06-01

    cAMP-dependent protein kinase (PKA) was the second protein kinase to be discovered and the PKA catalytic (C) subunit serves as a prototype for the large protein kinase superfamily that contains over 500 gene products. The protein kinases regulate much of biology in eukaryotic cells and they are now also a major therapeutic target. Although PKA was discovered nearly 50 years ago and the subsequent discovery of the regulatory subunits that bind cAMP and release the catalytic activity from the holoenzyme followed quickly. Thus in PKA we see the convergence of two major signaling mechanisms - protein phosphorylation and second messenger signaling through cAMP. Crystallography provides a foundation for understanding function, and the structure of the isolated regulatory (R) and C-subunits have been extremely informative. Yet it is the R 2 C 2 holoenzyme that predominates in cells, and one can only appreciate the allosteric features of PKA signaling by seeing the full length protein. The symmetry and the quaternary constraints that one R:C hetero-dimer exerts on the other in the holoenzyme simply are not present in the isolated subunits or even in the R:C hetero-dimer.

  10. Efficient Certification Path Discovery for MANET

    Directory of Open Access Journals (Sweden)

    Kambourakis Georgios

    2010-01-01

    Full Text Available A Mobile Ad Hoc Network (MANET is characterized by the lack of any infrastructure, absence of any kind of centralized administration, frequent mobility of nodes, network partitioning, and wireless connections. These properties make traditional wireline security solutions not straightforwardly applicable in MANETs, and of course, constitute the establishment of a Public Key Infrastructure (PKI in such networks a cumbersome task. After surveying related work, we propose a novel public key management scheme using the well-known web-of-trust or trust graph model. Our scheme is based on a binary tree formation of the network's nodes. The binary tree structure is proved very effective for building certificate chains between communicating nodes that are multihops away and the cumbersome problem of certificate chain discovery is avoided. We compare our scheme with related work and show that it presents several advantages, especially when a fair balancing between security and performance is desirable. Simulations of the proposed scheme under different scenarios demonstrate that it is effective in terms of tree formation, join and leave occurrences, and certificate chain establishment.

  11. The centenary of the discovery of isotopes

    International Nuclear Information System (INIS)

    Soulie, Edgar

    2013-01-01

    This article recalls works performed by different scientists (Marckwald and Keetman, Stromholm and Svedberg, Soddy, Thompson, Aston) which resulted in the observation and identification of the existence of isotopes. The author also recalls various works related to mechanisms of production of isotopes, the discovery of uranium fission and the principle of chain reaction. The author notably evokes French scientists involved in the development of mass spectroscopy and in the research and applications on isotopes within the CEA after the Second World War. A bibliography of article and books published by one of them, Etienne Roth, is provided. References deal with nuclear applications of chemical engineering (heavy water and its production, chemical processes in fission reactors, tritium extraction and enrichment), isotopic fractioning and physical-chemical processes, mass spectrometry and isotopic analysis, isotopic geochemistry (on 07;Earth, search for deuterium in moon rocks and their consequences), first dating and the Oklo phenomenon, radioactive dating, water and climate (isotopic hydrology, isotopes and hailstone formation, the atmosphere), and miscellaneous scientific fields (nuclear measurements and radioactivity, isotopic abundances and atomic weight, isotopic separation and use of steady isotopes)

  12. Computational discovery of extremal microstructure families

    Science.gov (United States)

    Chen, Desai; Skouras, Mélina; Zhu, Bo; Matusik, Wojciech

    2018-01-01

    Modern fabrication techniques, such as additive manufacturing, can be used to create materials with complex custom internal structures. These engineered materials exhibit a much broader range of bulk properties than their base materials and are typically referred to as metamaterials or microstructures. Although metamaterials with extraordinary properties have many applications, designing them is very difficult and is generally done by hand. We propose a computational approach to discover families of microstructures with extremal macroscale properties automatically. Using efficient simulation and sampling techniques, we compute the space of mechanical properties covered by physically realizable microstructures. Our system then clusters microstructures with common topologies into families. Parameterized templates are eventually extracted from families to generate new microstructure designs. We demonstrate these capabilities on the computational design of mechanical metamaterials and present five auxetic microstructure families with extremal elastic material properties. Our study opens the way for the completely automated discovery of extremal microstructures across multiple domains of physics, including applications reliant on thermal, electrical, and magnetic properties. PMID:29376124

  13. Discovery Mondays: The very early Universe

    CERN Multimedia

    2003-01-01

    Copyright NASARetracing the very early Universe to understand why there is "something rather than nothing" is one of the challenges facing astrophysics today. It is also the theme of the third Discovery Monday, to be held in the Microcosm on 7 July, where you will be welcomed by a number of scientists. A professional astronomer will allow you to look through his telescope and explain how it works. A cosmologist will talk to you about the very early Universe and a CERN physicist will show you how it's possible to trap antimatter. The mirror of matter, antimatter should have existed in the same quantities as matter in the very early stages of the Universe but today it seems to have virtually disappeared. Perhaps the research being done at CERN will one day explain how an infinitesimal predominance of matter over antimatter resulted in such a richly structured Universe. Come along to the Microcosm on Monday, 7 July between 7.30 p.m. and 9.00 p.m. Entrance is free http://www.cern.ch/microcosm N.B.: The Discove...

  14. Discovery Mondays - 'Particle tracks: Seeing the invisible'

    CERN Multimedia

    2007-01-01

    Simulation of particle tracks in the CMS detector. How can you 'see' something as infinitesimal and fleeting as an elementary particle that defeats even the most powerful microscope? Well, physicists have detectors to snoop on them. Unlike biologists looking at bacteria, physicists don't see the particles themselves. They study their impact on sensitive materials as they pass through them at ultra high speed, a bit like seeing plane vapour trails in a clear sky. At the next Discovery Monday you will be able to find out about the different methods used at CERN to detect particles. There will be demonstrations of the cloud chamber, where particles leave tell-tale evidence of their passage in tracks of droplets. You will also learn about past and current particle track detection techniques and how the tracks are reconstructed into magnificent composite images. Don't miss this opportunity to learn about the various ways of 'seeing' particles. The event will be conducted in French. Come along to the Microcosm ...

  15. Discovery Mondays - Mass: a question of weight?

    CERN Multimedia

    2006-01-01

    Mass and weight: two rather commonplace phenomena on the surface of it, but would you be able to explain the difference between them? And do you know how gravity works? If you let go of a paperclip and an apple at the same time, which of the two will hit the floor first? At the next Discovery Monday scientists will introduce you to these concepts that are often rather difficult to get to grips with. Find out what kind of particles are thought to be responsible for mass and gravity. Get to know the graviton, a particle that has yet to be observed, has no mass or charge but is thought to be a messenger particle for gravity. You will also encounter the famous Higgs boson, which scientists believe could elucidate the mystery of mass and hope to discover with the LHC. An evening for tackling some very weighty questions... The event will be conducted in French. Join us at Microcosm (Reception, Building 33, Meyrin site), on Monday 6 March from 7.30 p.m. to 9.00 p.m. Entrance Free http://www.cern.ch/LundisDeco...

  16. Discovery Monday: Much ado about nothing: vacuums

    CERN Multimedia

    2004-01-01

    Most people seem to agree that an empty space has nothing in it. But what about the physicists? "Wait a minute!", they will tell you, at the Microcosm's next Discovery Monday on 5th April, for they know that even interstellar space is not as empty as it might seem... Because particles, the tiny constituents of matter, are everywhere. Even the most sophisticated vacuum pumps cannot get rid of them all. What's more, energy is omnipresent in the Universe. Energy has the habit of turning itself into matter then disappearing, only to come back again as energy... and all this in the twinkling of an eye. Hence the term "virtual matter". A completely empty space simply does not exist. Vacuums are of vital importance to CERN's physicists. In the accelerators, it is essential to obtain the best possible vacuum inside the tube through which the particles travel, in order to avoid interference from other, stray particles. To this end they use "getter" strips, which act like fly traps. When these strip...

  17. The discovery and characterization of riboflavin.

    Science.gov (United States)

    Northrop-Clewes, Christine A; Thurnham, David I

    2012-01-01

    The first observation of a pigment in milk with yellow-green fluorescence can be traced to the English chemist Alexander Wynter Blyth in 1872, but it was not until the early 1930s that the substance was characterized as riboflavin. Interest in accessory food factors began in the latter half of the 19th century with the discovery of the first vitamin, thiamin. Thiamin was water soluble and given the name vitamin B(1). However, researchers realized that there were one or more additional water-soluble factors and these were called the vitamin B-2 complex. The search to identify these accessory food factors in milk, whole wheat, yeast, and liver began in the early 1900s. As there is no classical nutritional disease attributable to riboflavin deficiency, it was the growth-stimulating properties of the food extracts given to young rats that provided the tool with which to investigate and eventually extract riboflavin. Riboflavin was the second vitamin to be isolated and the first from the vitamin B-2 complex; the essential nature of the vitamin as a food constituent for man was shown in 1939. Copyright © 2012 S. Karger AG, Basel.

  18. Drug-Target Kinetics in Drug Discovery.

    Science.gov (United States)

    Tonge, Peter J

    2018-01-17

    The development of therapies for the treatment of neurological cancer faces a number of major challenges including the synthesis of small molecule agents that can penetrate the blood-brain barrier (BBB). Given the likelihood that in many cases drug exposure will be lower in the CNS than in systemic circulation, it follows that strategies should be employed that can sustain target engagement at low drug concentration. Time dependent target occupancy is a function of both the drug and target concentration as well as the thermodynamic and kinetic parameters that describe the binding reaction coordinate, and sustained target occupancy can be achieved through structural modifications that increase target (re)binding and/or that decrease the rate of drug dissociation. The discovery and deployment of compounds with optimized kinetic effects requires information on the structure-kinetic relationships that modulate the kinetics of binding, and the molecular factors that control the translation of drug-target kinetics to time-dependent drug activity in the disease state. This Review first introduces the potential benefits of drug-target kinetics, such as the ability to delineate both thermodynamic and kinetic selectivity, and then describes factors, such as target vulnerability, that impact the utility of kinetic selectivity. The Review concludes with a description of a mechanistic PK/PD model that integrates drug-target kinetics into predictions of drug activity.

  19. Asymmetric threat data mining and knowledge discovery

    Science.gov (United States)

    Gilmore, John F.; Pagels, Michael A.; Palk, Justin

    2001-03-01

    Asymmetric threats differ from the conventional force-on- force military encounters that the Defense Department has historically been trained to engage. Terrorism by its nature is now an operational activity that is neither easily detected or countered as its very existence depends on small covert attacks exploiting the element of surprise. But terrorism does have defined forms, motivations, tactics and organizational structure. Exploiting a terrorism taxonomy provides the opportunity to discover and assess knowledge of terrorist operations. This paper describes the Asymmetric Threat Terrorist Assessment, Countering, and Knowledge (ATTACK) system. ATTACK has been developed to (a) data mine open source intelligence (OSINT) information from web-based newspaper sources, video news web casts, and actual terrorist web sites, (b) evaluate this information against a terrorism taxonomy, (c) exploit country/region specific social, economic, political, and religious knowledge, and (d) discover and predict potential terrorist activities and association links. Details of the asymmetric threat structure and the ATTACK system architecture are presented with results of an actual terrorist data mining and knowledge discovery test case shown.

  20. Antimicrobial discovery inspired by ecological interactions.

    Science.gov (United States)

    Molloy, Evelyn M; Hertweck, Christian

    2017-10-01

    Bacteria represent an unparalleled source of antibiotics used to treat infectious diseases. Yet, genome analyses have revealed that their full biosynthetic potential is much larger than expected. Valuable strategies to unearth hidden antibiotics are genome mining, pathway engineering and triggering, as well as co-cultivation approaches. Nevertheless, there is growing understanding that it is often essential to consider the ecological context and that there is a great potential for antimicrobial discovery from bacteria engaged in well-defined interactions with other organisms. Various ecological scenarios involving antimicrobial agents are outlined in this review: predator-prey and pathogenic interactions, the protection of insect assets such as offspring and cultivars, as well as host protection in symbiotic relationships with plants, invertebrates and animals/humans. The illustrative examples given reinforce the idea that examination of interactions between organisms can yield new antimicrobial compounds, and ultimately further our understanding of the function of these molecules in the environment. Copyright © 2017. Published by Elsevier Ltd.

  1. Knowledge Discovery in Data in Construction Projects

    Directory of Open Access Journals (Sweden)

    Szelka J.

    2016-06-01

    Full Text Available Decision-making processes, including the ones related to ill-structured problems, are of considerable significance in the area of construction projects. Computer-aided inference under such conditions requires the employment of specific methods and tools (non-algorithmic ones, the best recognized and successfully used in practice represented by expert systems. The knowledge indispensable for such systems to perform inference is most frequently acquired directly from experts (through a dialogue: a domain expert - a knowledge engineer and from various source documents. Little is known, however, about the possibility of automating knowledge acquisition in this area and as a result, in practice it is scarcely ever used. It has to be noted that in numerous areas of management more and more attention is paid to the issue of acquiring knowledge from available data. What is known and successfully employed in the practice of aiding the decision-making is the different methods and tools. The paper attempts to select methods for knowledge discovery in data and presents possible ways of representing the acquired knowledge as well as sample tools (including programming ones, allowing for the use of this knowledge in the area under consideration.

  2. Accelerators for Discovery Science and Security applications

    Energy Technology Data Exchange (ETDEWEB)

    Todd, A.M.M., E-mail: alan_todd@mail.aesys.net; Bluem, H.P.; Jarvis, J.D.; Park, J.H.; Rathke, J.W.; Schultheiss, T.J.

    2015-05-01

    Several Advanced Energy Systems (AES) accelerator projects that span applications in Discovery Science and Security are described. The design and performance of the IR and THz free electron laser (FEL) at the Fritz-Haber-Institut der Max-Planck-Gesellschaft in Berlin that is now an operating user facility for physical chemistry research in molecular and cluster spectroscopy as well as surface science, is highlighted. The device was designed to meet challenging specifications, including a final energy adjustable in the range of 15–50 MeV, low longitudinal emittance (<50 keV-psec) and transverse emittance (<20 π mm-mrad), at more than 200 pC bunch charge with a micropulse repetition rate of 1 GHz and a macropulse length of up to 15 μs. Secondly, we will describe an ongoing effort to develop an ultrafast electron diffraction (UED) source that is scheduled for completion in 2015 with prototype testing taking place at the Brookhaven National Laboratory (BNL) Accelerator Test Facility (ATF). This tabletop X-band system will find application in time-resolved chemical imaging and as a resource for drug–cell interaction analysis. A third active area at AES is accelerators for security applications where we will cover some top-level aspects of THz and X-ray systems that are under development and in testing for stand-off and portal detection.

  3. Brivaracetam: a rational drug discovery success story

    Science.gov (United States)

    Rogawski, M A

    2008-01-01

    Levetiracetam, the α-ethyl analogue of the nootropic piracetam, is a widely used antiepileptic drug (AED) that provides protection against partial seizures and is also effective in the treatment of primary generalized seizure syndromes including juvenile myoclonic epilepsy. Levetiracetam was discovered in 1992 through screening in audiogenic seizure susceptible mice and, 3 years later, was reported to exhibit saturable, stereospecific binding in brain to a ∼90 kDa protein, later identified as the ubiquitous synaptic vesicle glycoprotein SV2A. A large-scale screening effort to optimize binding affinity identified the 4-n-propyl analogue, brivaracetam, as having greater potency and a broadened spectrum of activity in animal seizure models. Recent phase II clinical trials demonstrating that brivaracetam is efficacious and well tolerated in the treatment of partial onset seizures have validated the strategy of the discovery programme. Brivaracetam is among the first clinically effective AEDs to be discovered by optimization of pharmacodynamic activity at a molecular target. PMID:18552880

  4. Percolator: Scalable Pattern Discovery in Dynamic Graphs

    Energy Technology Data Exchange (ETDEWEB)

    Choudhury, Sutanay; Purohit, Sumit; Lin, Peng; Wu, Yinghui; Holder, Lawrence B.; Agarwal, Khushbu

    2018-02-06

    We demonstrate Percolator, a distributed system for graph pattern discovery in dynamic graphs. In contrast to conventional mining systems, Percolator advocates efficient pattern mining schemes that (1) support pattern detection with keywords; (2) integrate incremental and parallel pattern mining; and (3) support analytical queries such as trend analysis. The core idea of Percolator is to dynamically decide and verify a small fraction of patterns and their in- stances that must be inspected in response to buffered updates in dynamic graphs, with a total mining cost independent of graph size. We demonstrate a) the feasibility of incremental pattern mining by walking through each component of Percolator, b) the efficiency and scalability of Percolator over the sheer size of real-world dynamic graphs, and c) how the user-friendly GUI of Percolator inter- acts with users to support keyword-based queries that detect, browse and inspect trending patterns. We also demonstrate two user cases of Percolator, in social media trend analysis and academic collaboration analysis, respectively.

  5. Discovery of potassium salts deposits in colombia

    International Nuclear Information System (INIS)

    Gonzalez Oviedo Leopoldo; Espinosa Baquero Armando

    2012-01-01

    The first potassium salts ores found in Colombia are presented and described; they are located in the Santander province, in La Mesa de los Santos area, between Los Santos village and the rio Chicamocha Canyon. From a geological point of view, the mineralization is associated to the sediments of the Paja Formation, Early Cretaceous in age, and is located near the base of the formation. In the study area the main structure is the Villanueva syncline which involves, from bottom to top, Los Santos, Rosablanca, Paja, Tablazo and Simiti formations.The mineralization consists of small veins where the main mineral is singenite (K 2 Ca[SO4] 2- H 2 O) with small amounts of carbonates and accidental minerals. In the host rock, minerals like langbeinite (K 2 Mg 2 [SO4] 3) andrinneite (K 3 Na[Fe,Cl] 6) are present; they show that the rock was formed in an evaporitic environment and that detailed studies of that sequence may lead to the discovery of other mineralizations of economic interest.

  6. Web proxy auto discovery for the WLCG

    CERN Document Server

    Dykstra, D; Blumenfeld, B; De Salvo, A; Dewhurst, A; Verguilov, V

    2017-01-01

    All four of the LHC experiments depend on web proxies (that is, squids) at each grid site to support software distribution by the CernVM FileSystem (CVMFS). CMS and ATLAS also use web proxies for conditions data distributed through the Frontier Distributed Database caching system. ATLAS & CMS each have their own methods for their grid jobs to find out which web proxies to use for Frontier at each site, and CVMFS has a third method. Those diverse methods limit usability and flexibility, particularly for opportunistic use cases, where an experiment’s jobs are run at sites that do not primarily support that experiment. This paper describes a new Worldwide LHC Computing Grid (WLCG) system for discovering the addresses of web proxies. The system is based on an internet standard called Web Proxy Auto Discovery (WPAD). WPAD is in turn based on another standard called Proxy Auto Configuration (PAC). Both the Frontier and CVMFS clients support this standard. The input into the WLCG system comes from squids regis...

  7. The discovery of isotopes a complete compilation

    CERN Document Server

    Thoennessen, Michael

    2016-01-01

    This book describes the exciting discovery of every isotope observed on earth to date, which currently numbers some 3000. For each isotope a short essay highlights the authors of the first publication for the isotope, the laboratory and year where and when the isotope was discovered, as well as details about the production and detection methods used. In controversial cases previously claims are also discussed. At the end a comprehensive table lists all isotopes sorted by elements and a complete list of references. Preliminary versions of these paragraphs have been published over the last few years as separate articles in the journal "Atomic Data and Nuclear Data Tables". The work re-evaluates all assignments judging them with a uniform set of criteria. In addition, the author includes over 100 new isotopes which have been discovered since the articles published. This book is a source of information for researchers as well as enthusiastic laymen alike. From the prepublication review: “The explanations focus ...

  8. AMS gets lift on space shuttle Discovery

    CERN Multimedia

    2009-01-01

    AMS-02, the CERN-recognized experiment that will seek dark matter, missing matter and antimatter in Space aboard the International Space Station (ISS), has recently got the green light to be part of the STS-134 NASA mission in 2010. Installation of AMS detectors in the Prévessin experiment hall.In a recent press release, NASA announced that the last or last-but-one mission of the Space Shuttle programme would be the one that will deliver AMS, the Alpha Magnetic Spectrometer, to the International Space Station. The Space Shuttle Discovery is due to lift off in July 2010 from Kennedy Space Center and its mission will include the installation of AMS to the exterior of the space station, using both the shuttle and station arms. "It wasn’t easy to get a lift on the Space Shuttle from the Bush administration," says professor Samuel Ting, spokesperson of the experiment, "since during his administration all the funds for space research w...

  9. Discovery Mondays: "Robots: At your service!"

    CERN Multimedia

    2005-01-01

    Two of the ISOLDE robots. Robots at CERN? Yes, because their presence is essential for replacing human beings when some tasks are too difficult for them, for example when materials are too fragile or too risky to work with. Come and discover the ISOLDE robots. You will also be able to meet "the Crab", in charge of carrying the LHC magnets in its claws. EPFL engineers from Autonomous Systems Lab and the Laboratory of Intelligent Systems will introduce you to some of their creations, including a robot built for planetary exploration, an indoor flying robot and a microrobot as tiny as a lump of sugar. At the next Discovery Monday, you will have the opportunity to meet robots of many sizes and forms. You will be amazed by their diversity and their personalities. Join us at the Microcosm (Reception Building 33, Meyrin site) on Monday 4 April from 7.30 p.m. to 9.00 p.m. Entrance Free http://www.cern.ch/microcosm http://intranet.cern.ch/Microcosm/LundisDecouverte/

  10. Discovery Mondays: "Robots: At your service!"

    CERN Multimedia

    2005-01-01

    Two of the ISOLDE robots. Robots at CERN? Yes, because their presence is essential for replacing human beings when some tasks are too difficult for them, for example when materials are too fragile or too risky to work with. Come and discover the ISOLDE robots. You will also be able to meet "the Crab", in charge of carrying the LHC magnets in its claws. EPFL engineers from Autonomous Systems Lab and the Laboratory of Intelligent Systems will introduce you to some of their creations, including a robot built for planetary exploration, an indoor flying robot and a microrobot as tiny as a lump of sugar. At the next Discovery Monday, you will have the opportunity to meet robots of many sizes and forms. You will be amazed by their diversity and their personalities. Join us at the Microcosm (Reception Building 33, Meyrin site) on Monday 4 April from 7.30 p.m. to 9.00 p.m. Entrance Free http://www.cern.ch/microcosm http://cern.ch/lundisdecouverte

  11. Discovery of Intrinsic Primitives on Triangle Meshes

    KAUST Repository

    Solomon, Justin

    2011-04-01

    The discovery of meaningful parts of a shape is required for many geometry processing applications, such as parameterization, shape correspondence, and animation. It is natural to consider primitives such as spheres, cylinders and cones as the building blocks of shapes, and thus to discover parts by fitting such primitives to a given surface. This approach, however, will break down if primitive parts have undergone almost-isometric deformations, as is the case, for example, for articulated human models. We suggest that parts can be discovered instead by finding intrinsic primitives, which we define as parts that posses an approximate intrinsic symmetry. We employ the recently-developed method of computing discrete approximate Killing vector fields (AKVFs) to discover intrinsic primitives by investigating the relationship between the AKVFs of a composite object and the AKVFs of its parts. We show how to leverage this relationship with a standard clustering method to extract k intrinsic primitives and remaining asymmetric parts of a shape for a given k. We demonstrate the value of this approach for identifying the prominent symmetry generators of the parts of a given shape. Additionally, we show how our method can be modified slightly to segment an entire surface without marking asymmetric connecting regions and compare this approach to state-of-the-art methods using the Princeton Segmentation Benchmark. © 2011 The Author(s).

  12. The Higgs Boson Search and Discovery

    CERN Document Server

    Bernardi, Gregorio

    2016-01-01

    We present a brief account of the search for the Higgs boson at the three major colliders that have operated over the last three decades: LEP, the Tevatron, and the LHC. The experimental challenges encountered stemmed from the distinct event phenomenology as determined by the colliders energy and the possible values for the Higgs boson mass, and from the capability of these colliders to deliver as much collision data as possible to fully explore the mass spectrum within their reach. Focusing more on the hadron collider searches during the last decade, we discuss how the search for the Higgs boson was advanced through mastering the experimental signatures of standard theory backgrounds, through the comprehensive utilization of the features of the detectors involved in the searches, and by means of advanced data analysis techniques. The search culminated in 2012 with the discovery, by the ATLAS and CMS collaborations, of a Higgs-like particle with mass close to 125 GeV, confirmed more recently to have propertie...

  13. Discovery Mondays: 'Separating science from fiction'

    CERN Multimedia

    2006-01-01

    Photo credit: ESA/NASA, the AVO project and Paolo PadovaniDoes the imaginary word of fiction always end up becoming scientific reality? What futuristic visions can we extrapolate from today's technologies? Here is a short quiz to test your knowledge. Can YOU tell truth from fiction? True False The laser swords featuring in the Star Wars films really exist. Time travel is possible using black holes. You could eat a cake of antimatter. Levitation vehicles really exist. Dan Brown is a space alien. How can you distinguish truth from fiction, dreams from reality, real science and technology from the sci-fi fantasies so realistically described in novels, television and cinema? You are invited to come and discuss these questions at a Discovery Monday at the very frontiers of science..... Join us at Microcosm (Reception, Building 33, Meyrin site), on Monday, 4 September from 7:30 p.m. to 9 p.m. Entrance Free The event will be conducted in French. http://www.cern.ch/LundisDecouverte/ ...

  14. Accelerators for Discovery Science and Security applications

    International Nuclear Information System (INIS)

    Todd, A.M.M.; Bluem, H.P.; Jarvis, J.D.; Park, J.H.; Rathke, J.W.; Schultheiss, T.J.

    2015-01-01

    Several Advanced Energy Systems (AES) accelerator projects that span applications in Discovery Science and Security are described. The design and performance of the IR and THz free electron laser (FEL) at the Fritz-Haber-Institut der Max-Planck-Gesellschaft in Berlin that is now an operating user facility for physical chemistry research in molecular and cluster spectroscopy as well as surface science, is highlighted. The device was designed to meet challenging specifications, including a final energy adjustable in the range of 15–50 MeV, low longitudinal emittance (<50 keV-psec) and transverse emittance (<20 π mm-mrad), at more than 200 pC bunch charge with a micropulse repetition rate of 1 GHz and a macropulse length of up to 15 μs. Secondly, we will describe an ongoing effort to develop an ultrafast electron diffraction (UED) source that is scheduled for completion in 2015 with prototype testing taking place at the Brookhaven National Laboratory (BNL) Accelerator Test Facility (ATF). This tabletop X-band system will find application in time-resolved chemical imaging and as a resource for drug–cell interaction analysis. A third active area at AES is accelerators for security applications where we will cover some top-level aspects of THz and X-ray systems that are under development and in testing for stand-off and portal detection

  15. A brief history of the ''Delayed'' discovery of nuclear fission

    International Nuclear Information System (INIS)

    Holden, N.E.

    1989-08-01

    This year marks the Fiftieth Anniversary of the discovery of Nuclear Fission. In the early 1930's, the neutron was discovered, followed by the discovery of artificial radioactivity and then the use of the neutron to produce artificial radioactivity. The first experiments resulting in the fission of uranium took place in 1934. A paper which speculated on fission as an explanation was almost immediately published, yet no one took it seriously not even the author herself. Why did it take an additional five years before anyone realized what had occurred? This is an abnormally long time in a period when discoveries, particularly in nuclear physics, seemed to be almost a daily occurrence. The events which led up to the discovery are recounted, with an attempt made to put them into their historical perspective. The role played by Mendeleev's Periodic Table, the role of the natural radioactive decay chain of uranium, the discovery of protactinium, the apparent discovery of masurium (technetium) and a speculation on the reason why Irene Curie may have missed the discovery of nuclear fission will all be discussed. 43 refs

  16. Applying Hierarchical Task Analysis Method to Discovery Layer Evaluation

    Directory of Open Access Journals (Sweden)

    Marlen Promann

    2015-03-01

    Full Text Available Libraries are implementing discovery layers to offer better user experiences. While usability tests have been helpful in evaluating the success or failure of implementing discovery layers in the library context, the focus has remained on its relative interface benefits over the traditional federated search. The informal site- and context specific usability tests have offered little to test the rigor of the discovery layers against the user goals, motivations and workflow they have been designed to support. This study proposes hierarchical task analysis (HTA as an important complementary evaluation method to usability testing of discovery layers. Relevant literature is reviewed for the discovery layers and the HTA method. As no previous application of HTA to the evaluation of discovery layers was found, this paper presents the application of HTA as an expert based and workflow centered (e.g. retrieving a relevant book or a journal article method to evaluating discovery layers. Purdue University’s Primo by Ex Libris was used to map eleven use cases as HTA charts. Nielsen’s Goal Composition theory was used as an analytical framework to evaluate the goal carts from two perspectives: a users’ physical interactions (i.e. clicks, and b user’s cognitive steps (i.e. decision points for what to do next. A brief comparison of HTA and usability test findings is offered as a way of conclusion.

  17. Solution NMR Spectroscopy in Target-Based Drug Discovery.

    Science.gov (United States)

    Li, Yan; Kang, Congbao

    2017-08-23

    Solution NMR spectroscopy is a powerful tool to study protein structures and dynamics under physiological conditions. This technique is particularly useful in target-based drug discovery projects as it provides protein-ligand binding information in solution. Accumulated studies have shown that NMR will play more and more important roles in multiple steps of the drug discovery process. In a fragment-based drug discovery process, ligand-observed and protein-observed NMR spectroscopy can be applied to screen fragments with low binding affinities. The screened fragments can be further optimized into drug-like molecules. In combination with other biophysical techniques, NMR will guide structure-based drug discovery. In this review, we describe the possible roles of NMR spectroscopy in drug discovery. We also illustrate the challenges encountered in the drug discovery process. We include several examples demonstrating the roles of NMR in target-based drug discoveries such as hit identification, ranking ligand binding affinities, and mapping the ligand binding site. We also speculate the possible roles of NMR in target engagement based on recent processes in in-cell NMR spectroscopy.

  18. STS-95 Discovery in the VAB as launch preparations continue

    Science.gov (United States)

    1998-01-01

    United Space Alliance Forward Shop workers stand near the orbiter Discovery in the Vehicle Assembly Building . The orbiter is being prepared for mating with the external tank. Discovery displays the recently painted NASA logo, termed the 'meatball,' on its left, or port, wing. The logo also has been painted on both sides of the aft fuselage. Discovery (OV-103), the first of the orbiters to be launched with the new art work, is scheduled for its 25th flight, from Launch Pad 39B, on Oct. 29, 1998, for the STS-95 mission.

  19. Belated recognition: Lise Meitner's role in the discovery of fission

    International Nuclear Information System (INIS)

    Sime, R.L.

    1990-01-01

    Although physicist Lise Meitner is known for the first theoretical explanation of nuclear fission, the discovery itself is generally attributed only to her co-workers Otto Hahn and Fritz Strassmann. In fact, however, Meitner was essential to the discovery at every phase: she brought the uranium investigation to Berlin, led the Berlin group for four years, and, even after fleeing Germany, provided the critical direction which culminated in the identification of barium in December 1983. Recognition of Lise Meitner's contributions remedies a significant historical omission, and places the discovery itself in its proper scientific context. (author) 48 refs

  20. Resource Discovery in Activity-Based Sensor Networks

    DEFF Research Database (Denmark)

    Bucur, Doina; Bardram, Jakob

    This paper proposes a service discovery protocol for sensor networks that is specifically tailored for use in humancentered pervasive environments. It uses the high-level concept of computational activities (as logical bundles of data and resources) to give sensors in Activity-Based Sensor Networks...... (ABSNs) knowledge about their usage even at the network layer. ABSN redesigns classical network-level service discovery protocols to include and use this logical structuring of the network for a more practically applicable service discovery scheme. Noting that in practical settings activity-based sensor...

  1. Throughput Capacity of Ad Hoc Networks with Route Discovery

    Directory of Open Access Journals (Sweden)

    Blum Rick S

    2007-01-01

    Full Text Available Throughput capacity of large ad hoc networks has been shown to scale adversely with the size of network . However the need for the nodes to find or repair routes has not been analyzed in this context. In this paper, we explicitly take route discovery into account and obtain the scaling law for the throughput capacity under general assumptions on the network environment, node behavior, and the quality of route discovery algorithms. We also discuss a number of possible scenarios and show that the need for route discovery may change the scaling for the throughput capacity.

  2. Technical summaries of Scotian Shelf - significant and commercial discoveries

    International Nuclear Information System (INIS)

    Dickey, J.E.; Bigelow, S.F.; Edens, J.A.; Brown, D.E.; Smith, B.; Makrides, C.; Mader, R.

    1997-03-01

    An independent assessment of the recoverable hydrocarbon resource currently held under' Significant and Commercial Discovery' status offshore Nova Scotia was presented. A generalized description of the regulatory issues regarding the discovered resources within the Scotian Basin was included. Twenty discoveries have been declared significant and two have been declared commercial, pursuant to the Canada-Nova Scotia Offshore Petroleum Resources Accord Implementation Acts. Salient facts about each discovery were documented. The information included the wells drilled within the structure, significant flow tests, geological and geophysical attributes, structural cross-section and areal extent, petrophysical parameters, hydrocarbons in place and anticipated hydrocarbon recoverable resource. tabs., figs

  3. Use of combinatorial chemistry to speed drug discovery.

    Science.gov (United States)

    Rádl, S

    1998-10-01

    IBC's International Conference on Integrating Combinatorial Chemistry into the Discovery Pipeline was held September 14-15, 1998. The program started with a pre-conference workshop on High-Throughput Compound Characterization and Purification. The agenda of the main conference was divided into sessions of Synthesis, Automation and Unique Chemistries; Integrating Combinatorial Chemistry, Medicinal Chemistry and Screening; Combinatorial Chemistry Applications for Drug Discovery; and Information and Data Management. This meeting was an excellent opportunity to see how big pharma, biotech and service companies are addressing the current bottlenecks in combinatorial chemistry to speed drug discovery. (c) 1998 Prous Science. All rights reserved.

  4. Fungal Anticancer Metabolites: Synthesis Towards Drug Discovery.

    Science.gov (United States)

    Barbero, Margherita; Artuso, Emma; Prandi, Cristina

    2018-01-01

    Fungi are a well-known and valuable source of compounds of therapeutic relevance, in particular of novel anticancer compounds. Although seldom obtainable through isolation from the natural source, the total organic synthesis still remains one of the most efficient alternatives to resupply them. Furthermore, natural product total synthesis is a valuable tool not only for discovery of new complex biologically active compounds but also for the development of innovative methodologies in enantioselective organic synthesis. We undertook an in-depth literature searching by using chemical bibliographic databases (SciFinder, Reaxys) in order to have a comprehensive insight into the wide research field. The literature has been then screened, refining the obtained results by subject terms focused on both biological activity and innovative synthetic procedures. The literature on fungal metabolites has been recently reviewed and these publications have been used as a base from which we consider the synthetic feasibility of the most promising compounds, in terms of anticancer properties and drug development. In this paper, compounds are classified according to their chemical structure. This review summarizes the anticancer potential of fungal metabolites, highlighting the role of total synthesis outlining the feasibility of innovative synthetic procedures that facilitate the development of fungal metabolites into drugs that may become a real future perspective. To our knowledge, this review is the first effort to deal with the total synthesis of these active fungi metabolites and demonstrates that total chemical synthesis is a fruitful means of yielding fungal derivatives as aided by recent technological and innovative advancements. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  5. Planetary Sciences Literature - Access and Discovery

    Science.gov (United States)

    Henneken, Edwin A.; ADS Team

    2017-10-01

    The NASA Astrophysics Data System (ADS) has been around for over 2 decades, helping professional astronomers and planetary scientists navigate, without charge, through the increasingly complex environment of scholarly publications. As boundaries between disciplines dissolve and expand, the ADS provides powerful tools to help researchers discover useful information efficiently. In its new form, code-named ADS Bumblebee (https://ui.adsabs.harvard.edu), it may very well answer questions you didn't know you had! While the classic ADS (http://ads.harvard.edu) focuses mostly on searching basic metadata (author, title and abstract), today's ADS is best described as a an "aggregator" of scholarly resources relevant to the needs of researchers in astronomy and planetary sciences, and providing a discovery environment on top of this. In addition to indexing content from a variety of publishers, data and software archives, the ADS enriches its records by text-mining and indexing the full-text articles (about 4.7 million in total, with 130,000 from planetary science journals), enriching its metadata through the extraction of citations and acknowledgments. Recent technology developments include a new Application Programming Interface (API), a new user interface featuring a variety of visualizations and bibliometric analysis, and integration with ORCID services to support paper claiming. The new ADS provides powerful tools to help you find review papers on a given subject, prolific authors working on a subject and who they are collaborating with (within and outside their group) and papers most read by by people who read recent papers on the topic of your interest. These are just a couple of examples of the capabilities of the new ADS. We currently index most journals covering the planetary sciences and we are striving to include those journals most frequently cited by planetary science publications. The ADS is operated by the Smithsonian Astrophysical Observatory under NASA

  6. The Coldest Discoveries of Backyard Worlds

    Science.gov (United States)

    Faherty, Jacqueline; Kuchner, Marc; Logsdon, Sarah; Bardalez Gagliuffi, Daniella; Meisner, Aaron; Schneider, Adam; Gagne, Jonathan; Caselden, Dan

    2018-05-01

    Over the past five years, our view of the local solar neighborhood has changed drastically thanks to the Wide Field Infrared Survey Explorer (WISE). Not only did WISE redefine the five closest systems to the Sun with the discovery of Luhman16AB and WISE0855, but it also revealed the Sun's closest fly by and it defined an entirely new class of extremely cold and close compact objects: the Y dwarfs. At present, all but two of the Y dwarfs were discovered through a WISE single epoch photometric identification. As a whole, these objects are of critical importance to identifying the efficiency of star formation at the lowest masses. As individuals, each of these objects represents a unique probe into the complex chemistry present in the coldest photospheres produced in the Universe. Every single Y dwarf discovered is an observational treasure. In February 2017, we launched a citizen science project called Backyard Worlds: Planet 9 with the intention of scanning the entire sky using not just photometric information but positional as well to identify the coldest, closest, and fastest moving objects near the Sun. In this Spitzer Cycle 14 proposal, we have identified 65 tantalizingly fast moving objects that appear to be extremely cold hence potentially among the Sun's nearest neighbors. We ask for 26.8 hours with Spitzer to obtain critical ch1 and ch2 photometry as well as astrometric information (to confirm motion) which will allow us to characterize these new cold brown dwarf neighbors. The coldest objects discovered through this proposal will be important follow-up targets for JWST spectroscopy.

  7. Symbiosis-inspired approaches to antibiotic discovery.

    Science.gov (United States)

    Adnani, Navid; Rajski, Scott R; Bugni, Tim S

    2017-07-06

    Covering: 2010 up to 2017Life on Earth is characterized by a remarkable abundance of symbiotic and highly refined relationships among life forms. Defined as any kind of close, long-term association between two organisms, symbioses can be mutualistic, commensalistic or parasitic. Historically speaking, selective pressures have shaped symbioses in which one organism (typically a bacterium or fungus) generates bioactive small molecules that impact the host (and possibly other symbionts); the symbiosis is driven fundamentally by the genetic machineries available to the small molecule producer. The human microbiome is now integral to the most recent chapter in animal-microbe symbiosis studies and plant-microbe symbioses have significantly advanced our understanding of natural products biosynthesis; this also is the case for studies of fungal-microbe symbioses. However, much less is known about microbe-microbe systems involving interspecies interactions. Microbe-derived small molecules (i.e. antibiotics and quorum sensing molecules, etc.) have been shown to regulate transcription in microbes within the same environmental niche, suggesting interspecies interactions whereas, intraspecies interactions, such as those that exploit autoinducing small molecules, also modulate gene expression based on environmental cues. We, and others, contend that symbioses provide almost unlimited opportunities for the discovery of new bioactive compounds whose activities and applications have been evolutionarily optimized. Particularly intriguing is the possibility that environmental effectors can guide laboratory expression of secondary metabolites from "orphan", or silent, biosynthetic gene clusters (BGCs). Notably, many of the studies summarized here result from advances in "omics" technologies and highlight how symbioses have given rise to new anti-bacterial and antifungal natural products now being discovered.

  8. What Does Galileo's Discovery of Jupiter's Moons Tell Us About the Process of Scientific Discovery?

    Science.gov (United States)

    Lawson, Anton E.

    In 1610, Galileo Galilei discovered Jupiter''smoons with the aid of a new morepowerful telescope of his invention. Analysisof his report reveals that his discoveryinvolved the use of at least three cycles ofhypothetico-deductive reasoning. Galileofirst used hypothetico-deductive reasoning to generateand reject a fixed star hypothesis.He then generated and rejected an ad hocastronomers-made-a-mistake hypothesis.Finally, he generated, tested, and accepted a moonhypothesis. Galileo''s reasoningis modeled in terms of Piaget''s equilibration theory,Grossberg''s theory of neurologicalactivity, a neural network model proposed by Levine &Prueitt, and another proposedby Kosslyn & Koenig. Given that hypothetico-deductivereasoning has played a rolein other important scientific discoveries, thequestion is asked whether it plays a rolein all important scientific discoveries. In otherwords, is hypothetico-deductive reasoningthe essence of the scientific method? Possiblealternative scientific methods, such asBaconian induction and combinatorial analysis,are explored and rejected as viablealternatives. Educational implications of thishypothetico-deductive view of scienceare discussed.

  9. Four disruptive strategies for removing drug discovery bottlenecks.

    Science.gov (United States)

    Ekins, Sean; Waller, Chris L; Bradley, Mary P; Clark, Alex M; Williams, Antony J

    2013-03-01

    Drug discovery is shifting focus from industry to outside partners and, in the process, creating new bottlenecks. Technologies like high throughput screening (HTS) have moved to a larger number of academic and institutional laboratories in the USA, with little coordination or consideration of the outputs and creating a translational gap. Although there have been collaborative public-private partnerships in Europe to share pharmaceutical data, the USA has seemingly lagged behind and this may hold it back. Sharing precompetitive data and models may accelerate discovery across the board, while finding the best collaborators, mining social media and mobile approaches to open drug discovery should be evaluated in our efforts to remove drug discovery bottlenecks. We describe four strategies to rectify the current unsustainable situation. Copyright © 2012 Elsevier Ltd. All rights reserved.

  10. Open discovery: An integrated live Linux platform of Bioinformatics tools.

    Science.gov (United States)

    Vetrivel, Umashankar; Pilla, Kalabharath

    2008-01-01

    Historically, live linux distributions for Bioinformatics have paved way for portability of Bioinformatics workbench in a platform independent manner. Moreover, most of the existing live Linux distributions limit their usage to sequence analysis and basic molecular visualization programs and are devoid of data persistence. Hence, open discovery - a live linux distribution has been developed with the capability to perform complex tasks like molecular modeling, docking and molecular dynamics in a swift manner. Furthermore, it is also equipped with complete sequence analysis environment and is capable of running windows executable programs in Linux environment. Open discovery portrays the advanced customizable configuration of fedora, with data persistency accessible via USB drive or DVD. The Open Discovery is distributed free under Academic Free License (AFL) and can be downloaded from http://www.OpenDiscovery.org.in.

  11. Reines-Cowan team discovery of the electron neutrino

    International Nuclear Information System (INIS)

    Kruse, Herald W.

    2011-01-01

    Personal perspective and recollections by the author discuss the Reines-Cowan team discovery of the electron neutrino at a Savannah River reactor in 1956. First presented at the Neutrino Santa Fe 2006 Conference.

  12. Discovery of anaerobic lithoheterotrophic haloarchaea, ubiquitous in hypersaline habitats

    NARCIS (Netherlands)

    Sorokin, D.Y.; Messina, E.; Smedile, F; Roman, P.; Sinninghe Damsté, J.S.; Ciordia, S.; Mena, M.C.; Ferrer, M.; Golyshin, P.N.; Kublanov, I.V.; Samarov, N.I.; Toshchakov, S.V.; La Cono, V.; Yakimov, M.M.

    2017-01-01

    Hypersaline anoxic habitats harbour numerous novel uncultured archaea whose metabolic and ecological roles remain to be elucidated. Until recently, it was believed that energy generation via dissimilatory reduction of sulfur compounds is not functional at salt saturation conditions. Recent discovery

  13. Plant natural products research in tuberculosis drug discovery and ...

    African Journals Online (AJOL)

    Plant natural products research in tuberculosis drug discovery and development: A situation report ... African Journal of Biotechnology ... tuberculosis (XDR-TB), call for the development of new anti-tuberculosis drugs to combat this disease.

  14. Book Review: Dispute Resolution and e-Discovery

    Directory of Open Access Journals (Sweden)

    Milton Luoma

    2012-09-01

    Full Text Available Garrie, D.B., & Griver, Y.M., Eds. (2012. Dispute Resolution and e-Discovery. Thomson Reuters Westlaw, 570 pages, ISBN-13: 9780314604484, US$149.00.Reviewed by Milton Luoma, JD, (Milt.Luoma@metrostate.eduAs is apparent from its title, this book tackles two very current and difficult legal issues – electronic discovery and dispute resolution. The authors tie the two legal concepts together in an effort to provide litigants and practitioners a less expensive and less time consuming alternative than is typically the case with traditional litigation and court proceedings. By including electronic discovery in the discussions, the authors recognize the importance and significance of electronic discovery in mediation and arbitration as it is in traditional litigation.(see PDF for full review

  15. Effectiveness of discovery learning model on mathematical problem solving

    Science.gov (United States)

    Herdiana, Yunita; Wahyudin, Sispiyati, Ririn

    2017-08-01

    This research is aimed to describe the effectiveness of discovery learning model on mathematical problem solving. This research investigate the students' problem solving competency before and after learned by using discovery learning model. The population used in this research was student in grade VII in one of junior high school in West Bandung Regency. From nine classes, class VII B were randomly selected as the sample of experiment class, and class VII C as control class, which consist of 35 students every class. The method in this research was quasi experiment. The instrument in this research is pre-test, worksheet and post-test about problem solving of mathematics. Based on the research, it can be conclude that the qualification of problem solving competency of students who gets discovery learning model on level 80%, including in medium category and it show that discovery learning model effective to improve mathematical problem solving.

  16. Biomarker discovery in high grade sarcomas by mass spectrometry imaging

    OpenAIRE

    Lou, S.

    2017-01-01

    This thesis demonstrates a detailed biomarker discovery Mass Spectrometry Imaging workflow for histologically heterogeneous high grade sarcomas. Panels of protein and metabolite signatures were discovered either distinguishing different histological subtypes or stratifying high risk patients with poor survival.

  17. Sparse Mbplsr for Metabolomics Data and Biomarker Discovery

    DEFF Research Database (Denmark)

    Karaman, İbrahim

    2014-01-01

    the link between high throughput metabolomics data generated on different analytical platforms, discover important metabolites deriving from the digestion processes in the gut, and automate metabolic pathway discovery from mass spectrometry. PLS (partial least squares) based chemometric methods were...

  18. Context-sensitive service discovery experimental prototype and evaluation

    DEFF Research Database (Denmark)

    Balken, Robin; Haukrogh, Jesper; L. Jensen, Jens

    2007-01-01

    The amount of different networks and services available to users today are increasing. This introduces the need for a way to locate and sort out irrelevant services in the process of discovering available services to a user. This paper describes and evaluates a prototype of an automated discovery...... and selection system, which locates services relevant to a user, based on his/her context and the context of the available services. The prototype includes a multi-level, hierarchical system approach and the introduction of entities called User-nodes, Super-nodes and Root-nodes. These entities separate...... the network in domains that handle the complex distributed service discovery, which is based on dynamically changing context information. In the prototype, a method for performing context-sensitive service discovery has been realised. The service discovery part utilizes UPnP, which has been expanded in order...

  19. Neuroscience-driven discovery and development of sleep therapeutics

    NARCIS (Netherlands)

    Dresler, M.; Spoormaker, V.I.; Beitinger, P.; Czisch, M.; Kimura, M.; Steiger, A.; Holsboer, F.

    2014-01-01

    Until recently, neuroscience has given sleep research and discovery of better treatments of sleep disturbances little attention, despite the fact that disturbed sleep has overwhelming impact on human health. Sleep is a complex phenomenon in which specific psychological, electrophysiological,

  20. Performance modeling of neighbor discovery in proactive routing protocols

    Directory of Open Access Journals (Sweden)

    Andres Medina

    2011-07-01

    Full Text Available It is well known that neighbor discovery is a critical component of proactive routing protocols in wireless ad hoc networks. However there is no formal study on the performance of proposed neighbor discovery mechanisms. This paper provides a detailed model of key performance metrics of neighbor discovery algorithms, such as node degree and the distribution of the distance to symmetric neighbors. The model accounts for the dynamics of neighbor discovery as well as node density, mobility, radio and interference. The paper demonstrates a method for applying these models to the evaluation of global network metrics. In particular, it describes a model of network connectivity. Validation of the models shows that the degree estimate agrees, within 5% error, with simulations for the considered scenarios. The work presented in this paper serves as a basis for the performance evaluation of remaining performance metrics of routing protocols, vital for large scale deployment of ad hoc networks.