WorldWideScience

Sample records for single-stem systems primarily

  1. PICK1 expression in the Drosophila central nervous system primarily occurs in the neuroendocrine system

    DEFF Research Database (Denmark)

    Jansen, Anna M; Nässel, Dick R; Madsen, Kenneth L

    2009-01-01

    in the adult and larval Drosophila central nervous system. PICK1 was found in cell bodies in the subesophageal ganglion, the antennal lobe, the protocerebrum, and the neuroendocrine center pars intercerebralis. The cell types that express PICK1 were identified using GAL4 enhancer trap lines. The PICK1...... (AMPA) receptor subunit GluR2 and the dopamine transporter. PICK1 is strongly implicated in GluR2 trafficking and synaptic plasticity. In mammals, PICK1 has been characterized extensively in cell culture studies. To study PICK1 in an intact system, we characterized PICK1 expression immunohistochemically...... neurons in the neuroendocrine system, which express the transcription factor DIMM and the amidating enzyme peptidylglycine-alpha-hydroxylating monooxygenase (PHM). The PICK1-positive cells include neurosecretory cells that produce the insulin-like peptide dILP2. PICK1 expression in insulin-producing cells...

  2. Siting studies for an asymptotic U.S. energy supply system based primarily on nuclear energy

    International Nuclear Information System (INIS)

    Burwell, C.C.

    1977-01-01

    The nuclear energy center (NEC) concept is an approach to siting wherein nuclear facilities would be clustered in and delimited to a relatively small number of locations throughout the United States. These designated centers would be concurrently developed to their full capability over several decades, at which time, they would be several times larger than the largest nuclear power stations in existence today. The centers would be permanently dedicated to nuclear operations including the future decommissioning of functionally obsolescent facilities as well as the commissioning of their replacements. The criteria for and characteristics of an acceptable nuclear energy system that could supply most of the U.S. energy requirements in the distant future are discussed. The time period is unspecified but occurs when fossil-fuel resources are depleted to such an extent that their use is economic only in special situations, and is not economic, in general, for use as fuel

  3. Efficient transfection of primarily cultured porcine embryonic fibroblasts using the Amaxa Nucleofection system.

    Science.gov (United States)

    Nakayama, Asuka; Sato, Masahiro; Shinohara, Mariko; Matsubara, Shyuichiro; Yokomine, Takaaki; Akasaka, Eri; Yoshida, Mitsutoshi; Takao, Sonshin

    2007-01-01

    Porcine embryonic fibroblasts (PEF) are important as donor cells for nuclear transfer for generation of genetically modified pigs. In this study, we determined an optimal protocol for transfection of PEF with the Amaxa Nucleofection system, which directly transfers DNA into the nucleus of cells, and compared its efficiency with conventional lipofection and electroporation. Cell survival and transfection efficiency were assessed using dye-exclusion assay and a green fluorescent protein (GFP) reporter construct, respectively. Our optimized nucleofection parameters yielded survival rates above 60%. Under these conditions, FACS analysis demonstrated that 79% of surviving cells exhibited transgene expression 48 h after nucleofection when program U23 was used. This efficiency was higher than that of transfection of PEFs with electroporation (ca. 3-53%) or lipofection (ca. 3-8%). Transfected cells could be expanded as stably transgene-expressing clones over a month. When porcine nuclear transfer (NT) was performed using stable transformant expressing GFP as a donor cell, 5-6% of reconstituted embryos developed to blastocysts, from which 30-50% of embryos exhibited NT-embryo-derived green fluorescence. Under the conditions evaluated, nucleofection exhibited higher efficiency than conventional electroporation and lipofection, and may be a useful alternative for generation of genetically engineered pigs through nuclear transfer.

  4. Flow mapping of multiphase flows using a novel single stem endoscopic particle image velocimetry instrument

    International Nuclear Information System (INIS)

    Lad, N; Adebayo, D; Aroussi, A

    2011-01-01

    Particle image velocimetry (PIV) is a successful flow mapping technique which can optically quantify large portions of a flow regime. This enables the method to be completely non-intrusive. The ability to be non-intrusive to any flow has allowed PIV to be used in a large range of industrial sectors for many applications. However, a fundamental disadvantage of the conventional PIV technique is that it cannot easily be used with flows which have no or limited optical access. Flows which have limited optical access for PIV measurement have been addressed using endoscopic PIV techniques. This system uses two separate probes which relay a light sheet and imaging optics to a planar position within the desired flow regime. This system is effective in medical and engineering applications. The present study has been involved in the development of a new endoscopic PIV system which integrates the illumination and imaging optics into one rigid probe. This paper focuses on the validation of the images taken from the novel single stem endoscopic PIV system. The probe is used within atomized spray flow and is compared with conventional PIV measurement and also pitot-static data. The endoscopic PIV system provides images which create localized velocity maps that are comparable with the global measurement of the conventional PIV system. The velocity information for both systems clearly show similar results for the spray characterization and are also validated using the pitot-static data

  5. Systemic administration of guanfacine improves food-motivated impulsive choice behavior primarily via direct stimulation of postsynaptic α2A-adrenergic receptors in rats.

    Science.gov (United States)

    Nishitomi, Kouhei; Yano, Koji; Kobayashi, Mika; Jino, Kohei; Kano, Takuya; Horiguchi, Naotaka; Shinohara, Shunji; Hasegawa, Minoru

    2018-06-01

    Impulsive choice behavior, which can be assessed using the delay discounting task, is a characteristic of various psychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD). Guanfacine is a selective α 2A -adrenergic receptor agonist that is clinically effective in treating ADHD. However, there is no clear evidence that systemic guanfacine administration reduces impulsive choice behavior in the delay discounting task in rats. In the present study, we examined the effect of systemic guanfacine administration on food-motivated impulsive choice behavior in rats and the neuronal mechanism underlying this effect. Repeated administration of either guanfacine, methylphenidate, or atomoxetine significantly enhanced impulse control, increasing the number of times the rats chose a large but delayed reward in a dose-dependent manner. The effect of guanfacine was significantly blocked by pretreatment with an α 2A -adrenergic receptor antagonist. Furthermore, the effect of guanfacine remained unaffected in rats pretreated with a selective noradrenergic neurotoxin, consistent with a post-synaptic action. In contrast, the effect of atomoxetine on impulsive choice behavior was attenuated by pretreatment with the noradrenergic neurotoxin. These results provide the first evidence that systemically administered guanfacine reduces impulsive choice behavior in rats and that direct stimulation of postsynaptic, rather than presynaptic, α 2A -adrenergic receptors is involved in this effect. Copyright © 2018 Elsevier B.V. All rights reserved.

  6. Atrazine is primarily responsible for the toxicity of long-term exposure to a combination of atrazine and inorganic arsenic in the nigrostriatal system of the albino rat.

    Science.gov (United States)

    Bardullas, Ulises; Giordano, Magda; Rodríguez, Verónica Mireya

    2013-01-01

    Chronic and simultaneous exposure to a variety of chemicals present in the environment is an unavoidable fact. However, given the complexity of studying chemical mixtures, most toxicological studies have focused on the effects of short-term exposure to single substances. The aim of this study was to evaluate the effects on the nigrostriatal system of the chronic, simultaneous exposure to two widely distributed substances that have been identified as potential dopaminergic system toxicants, inorganic arsenic (iAs) and atrazine (ATR). Six groups of rats were treated daily for one year with atrazine (10mg ATR/kg), inorganic arsenic (0.5 or 50mgiAs/L of drinking water), or a combination of ATR+0.5mgiAs/L or ATR+50mgiAs/L. The 50mgiAs/L group showed locomotor hypoactivity, while all treatments decreased motor coordination in contrast no effects of treatment were found on the place and response learning tasks. Regarding markers for liver and muscle damage, there were no differences between groups in creatine kinase (CK) or aspartate transaminase (AST) activities, while decreases in lactate dehydrogenase (LDH) levels were found in some exposed groups. The striatal DA content was significantly reduced in ATR, 0.5mgiAs/L, ATR+0.5mgiAs/L, and ATR+50mgiAs/L groups, in comparison to the control group. The number of mesencephalic tyrosine hydroxylase positive cells decreased in the ATR and ATR+0.5mgiAs/L groups compared to the control. In contrast, immunoreactivity to cytochrome oxidase was reduced compared to the control in all treated groups, except for the group treated with 0.5iAsmg alone. Our results indicate that ATR has deleterious effects on dopaminergic neurons and that the combination of ATR and iAs does not exacerbate these effects. © 2013 Elsevier Inc. All rights reserved.

  7. Anaerobic expression of the gadE-mdtEF multidrug efflux operon is primarily regulated by the two-component system ArcBA through antagonizing the H-NS mediated repression.

    Science.gov (United States)

    Deng, Ziqing; Shan, Yue; Pan, Qing; Gao, Xiang; Yan, Aixin

    2013-01-01

    The gadE-mdtEF operon encodes a central acid resistance regulator GadE and two multidrug efflux proteins MdtEF. Although transcriptional regulation of gadE in the context of acid resistance under the aerobic growth environment of Escherichia coli has been extensively studied, regulation of the operon under the physiologically relevant environment of anaerobic growth and its effect on the expression of the multidrug efflux proteins MdtEF in the operon has not been disclosed. Our previous study revealed that anaerobic induction of the operon was dependent on ArcA, the response regulator of the ArcBA two-component system, in the M9 glucose minimal medium. However, the detailed regulatory mechanism remains unknown. In this study, we showed that anaerobic activation of mdtEF was driven by the 798 bp unusually long gadE promoter. Deletion of evgA, ydeO, rpoS, and gadX which has been shown to activate the gadE expression during acid stresses under aerobic condition did not have a significant effect on the anaerobic activation of the operon. Rather, anaerobic activation of the operon was largely dependent on the global regulator ArcA and a GTPase MnmE. Under aerobic condition, transcription of gadE was repressed by the global DNA silencer H-NS in M9 minimal medium. Interestingly, under anaerobic condition, while ΔarcA almost completely abolished transcription of gadE-mdtEF, further deletion of hns in ΔarcA mutant restored the transcription of the full-length PgadE-lacZ, and P1- and P3-lacZ fusions, suggesting an antagonistic effect of ArcA on the H-NS mediated repression. Taken together, we conclude that the anaerobic activation of the gadE-mdtEF was primarily mediated by the two-component system ArcBA through antagonizing the H-NS mediated repression.

  8. Anaerobic expression of the gadE-mdtEF multidrug efflux operon is primarily regulated by the two-component system ArcBA through antagonizing the H-NS mediated repression

    Directory of Open Access Journals (Sweden)

    Ziqing eDeng

    2013-07-01

    Full Text Available The gadE-mdtEF operon encodes a central acid resistance regulator GadE and two multidrug efflux proteins MdtEF. Although transcriptional regulation of gadE in the context of acid resistance under the aerobic growth environment of E. coli has been extensively studied, regulation of the operon under the physiologically relevant environment of anaerobic growth and its effect on the expression of the multidrug efflux proteins MdtEF has not been disclosed. Our previous study revealed that anaerobic induction of the operon was dependent on ArcA, the response regulator of the ArcBA two-component system, in the M9 glucose minimal medium. However, the detailed regulatory mechanism remains unknown. In this study, we showed that anaerobic activation of mdtEF was driven by the 798bp unusually long gadE promoter. Deletion of evgA, ydeO, rpoS, and gadX which has been shown to activate the gadE expression during acid stresses under aerobic condition did not have a significant effect on the anaerobic activation of the operon. Rather, anaerobic activation of the operon was largely dependent on the global regulator ArcA and a GTPase MnmE. Under aerobic condition, transcription of gadE was repressed by the global DNA silencer H-NS in M9 minimal medium. Interestingly, under anaerobic condition, while ΔarcA almost completely abolished transcription of gadE-mdtEF, further deletion of hns in ΔarcA mutant restored the transcription of the full length PgadE-lacZ, and P1- and P3-lacZ fusions, suggesting an antagonistic effect of ArcA on the H-NS mediated repression. Taken together, we conclude that the anaerobic activation of the gadE-mdtEF was primarily mediated by the two-component system ArcBA through antagonizing the H-NS mediated repression.

  9. Primarily Experimental Results for a W Wire Array Z Pinch

    International Nuclear Information System (INIS)

    Kuai Bin; Aici, Qiu; Wang Liangping; Zeng Zhengzhong; Wang Wensheng; Cong Peitian; Gai Tongyang; Wei Fuli; Guo Ning; Zhang Zhong

    2006-01-01

    Primarily experimental results are given for a W wire array Z pinch imploded with up to 2 MA in 100 ns on a Qiangguang-I pulsed power generator. The configuration and parameters of the generator, the W wire array load assembly and the diagnostic system for the experiment are described. The total X-ray energy has been obtained with a averaged power of X-ray radiation of 1.28 TW

  10. Central infusion of leptin improves insulin resistance and suppresses beta-cell function, but not beta-cell mass, primarily through the sympathetic nervous system in a type 2 diabetic rat model.

    Science.gov (United States)

    Park, Sunmin; Ahn, Il Sung; Kim, Da Sol

    2010-06-05

    We investigated whether hypothalamic leptin alters beta-cell function and mass directly via the sympathetic nervous system (SNS) or indirectly as the result of altered insulin resistant states. The 90% pancreatectomized male Sprague Dawley rats had sympathectomy into the pancreas by applying phenol into the descending aorta (SNSX) or its sham operation (Sham). Each group was divided into two sections, receiving either leptin at 300ng/kgbw/h or artificial cerebrospinal fluid (aCSF) via intracerebroventricular (ICV) infusion for 3h as a short-term study. After finishing the infusion study, ICV leptin (3mug/kg bw/day) or ICV aCSF (control) was infused in rats fed 30 energy % fat diets by osmotic pump for 4weeks. At the end of the long-term study, glucose-stimulated insulin secretion and islet morphometry were analyzed. Acute ICV leptin administration in Sham rats, but not in SNSX rats, suppressed the first- and second-phase insulin secretion at hyperglycemic clamp by about 48% compared to the control. Regardless of SNSX, the 4-week administration of ICV leptin improved glucose tolerance during oral glucose tolerance tests and insulin sensitivity at hyperglycemic clamp, compared to the control, while it suppressed second-phase insulin secretion in Sham rats but not in SNSX rats. However, the pancreatic beta-cell area and mass were not affected by leptin and SNSX, though ICV leptin decreased individual beta-cell size and concomitantly increased beta-cell apoptosis in Sham rats. Leptin directly decreases insulin secretion capacity mainly through the activation of SNS without modulating pancreatic beta-cell mass.

  11. Human punishment is not primarily motivated by inequality.

    Science.gov (United States)

    Marczyk, Jesse

    2017-01-01

    Previous theorizing about punishment has suggested that humans desire to punish inequality per se. However, the research supporting such an interpretation contains important methodological confounds. The main objective of the current experiment was to remove those confounds in order to test whether generating inequality per se is punished. Participants were recruited from an online market to take part in a wealth-alteration game with an ostensible second player. The participants were given an option to deduct from the other player's payment as punishment for their behavior during the game. The results suggest that human punishment does not appear to be motivated by inequality per se, as inequality that was generated without inflicting costs on others was not reliably punished. Instead, punishment seems to respond primarily to the infliction of costs, with inequality only becoming relevant as a secondary input for punishment decisions. The theoretical significance of this finding is discussed in the context of its possible adaptive value.

  12. Human punishment is not primarily motivated by inequality

    Science.gov (United States)

    Marczyk, Jesse

    2017-01-01

    Previous theorizing about punishment has suggested that humans desire to punish inequality per se. However, the research supporting such an interpretation contains important methodological confounds. The main objective of the current experiment was to remove those confounds in order to test whether generating inequality per se is punished. Participants were recruited from an online market to take part in a wealth-alteration game with an ostensible second player. The participants were given an option to deduct from the other player’s payment as punishment for their behavior during the game. The results suggest that human punishment does not appear to be motivated by inequality per se, as inequality that was generated without inflicting costs on others was not reliably punished. Instead, punishment seems to respond primarily to the infliction of costs, with inequality only becoming relevant as a secondary input for punishment decisions. The theoretical significance of this finding is discussed in the context of its possible adaptive value. PMID:28187166

  13. Human punishment is not primarily motivated by inequality.

    Directory of Open Access Journals (Sweden)

    Jesse Marczyk

    Full Text Available Previous theorizing about punishment has suggested that humans desire to punish inequality per se. However, the research supporting such an interpretation contains important methodological confounds. The main objective of the current experiment was to remove those confounds in order to test whether generating inequality per se is punished. Participants were recruited from an online market to take part in a wealth-alteration game with an ostensible second player. The participants were given an option to deduct from the other player's payment as punishment for their behavior during the game. The results suggest that human punishment does not appear to be motivated by inequality per se, as inequality that was generated without inflicting costs on others was not reliably punished. Instead, punishment seems to respond primarily to the infliction of costs, with inequality only becoming relevant as a secondary input for punishment decisions. The theoretical significance of this finding is discussed in the context of its possible adaptive value.

  14. Evidence for a single stem cell to reconstitute nearly one half of the total blood T cells in two A-bomb survivors

    International Nuclear Information System (INIS)

    Kodama, Y.; Nakano, M.; Itho, M.; Ohtaki, K.; Kusunoki, Y.; Nakamura, N.

    2003-01-01

    Full text: Recently, we have encountered two A-bomb survivors who had identical chromosome aberrations in their lymphocytes with very high frequencies; one survivor bore the same translocations in 40% of blood lymphocytes (case 1, estimated dose= 1.06 Sv) and the other had identical inversions and deletions in 30% of the lymphocytes (case 2, estimated dose 3.54 Sv). In case 1, the same abnormality was frequently observed in CD4 T cells, CD8 T cells, and EBV-transformed B cells as well, suggesting the origin in a bone marrow stem cell. Although it is generally thought that the clonal aberrations observed in A-bomb survivors were induced by A-bomb radiation, the results did not allow us to distinguish if the clone preexisted (i.e., as a mosaic individual) or was induced following radiation exposure. To discriminate these two possibilities, we applied 24-color FISH to detect additional non-clonal aberrations among the clonal cells. As these survivors bore various non-clonal translocations in about 30% (case 1) or 50% (case 2) of the lymphocytes that do not carry the clonal aberration, the rational is straightforward; if the clonal cells preexisted, we expected 30% or 50% of additional but non-clonal aberrations among the clonal cells. By contrast, if the clone emerged following the A-bomb radiation exposure, we expected a minimum frequency of additional aberrations among the clonal cells (i.e., close to the background aberration frequency observed in non-exposed people). The results showed that the frequency of additional translocations among the clonal cells was only 3% (3/101 cells) in case 1 and 1% (1/100) in case 2. Thus, the results clearly demonstrated that the clonal cells did not preexist and were produced as a result of extensive proliferation of a single stem cell following radiation exposure, which gave rise to comprise nearly one half of the total lymphocytes

  15. Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.

    Science.gov (United States)

    Stamler, J S; Jaraki, O; Osborne, J; Simon, D I; Keaney, J; Vita, J; Singel, D; Valeri, C R; Loscalzo, J

    1992-01-01

    We have recently shown that nitric oxide or authentic endothelium-derived relaxing factor generated in a biologic system reacts in the presence of specific protein thiols to form S-nitrosoprotein derivatives that have endothelium-derived relaxing factor-like properties. The single free cysteine of serum albumin, Cys-34, is particularly reactive toward nitrogen oxides (most likely nitrosonium ion) under physiologic conditions, primarily because of its anomalously low pK; given its abundance in plasma, where it accounts for approximately 0.5 mM thiol, we hypothesized that this plasma protein serves as a reservoir for nitric oxide produced by the endothelial cell. To test this hypothesis, we developed a methodology, which involves UV photolytic cleavage of the S--NO bond before reaction with ozone for chemiluminescence detection, with which to measure free nitric oxide, S-nitrosothiols, and S-nitrosoproteins in biologic systems. We found that human plasma contains approximately 7 microM S-nitrosothiols, of which 96% are S-nitrosoproteins, 82% of which is accounted for by S-nitroso-serum albumin. By contrast, plasma levels of free nitric oxide are only in the 3-nM range. In rabbits, plasma S-nitrosothiols are present at approximately 1 microM; 60 min after administration of NG-monomethyl-L-arginine at 50 mg/ml, a selective and potent inhibitor of nitric oxide synthetases, S-nitrosothiols decreased by approximately 40% (greater than 95% of which were accounted for by S-nitrosoproteins, and approximately 80% of which was S-nitroso-serum albumin); this decrease was accompanied by a concomitant increase in mean arterial blood pressure of 22%. These data suggest that naturally produced nitric oxide circulates in plasma primarily complexed in S-nitrosothiol species, principal among which is S-nitroso-serum albumin. This abundant, relatively long-lived adduct likely serves as a reservoir with which plasma levels of highly reactive, short-lived free nitric oxide can be

  16. X-ray and CT signs of connective tissue dysplasia in patients with primarily diagnosed infiltrative pulmonary tuberculosis

    International Nuclear Information System (INIS)

    Sukhanova, L.A.; Sharmazanova, O.P.

    2009-01-01

    The x-ray signs of connective tissue systemic dysplasia (CTSD) in patients with primarily diagnosed pulmonary tuberculosis was investigated. Fifty-four patients (28 med and 26 women aged 18-70) with primarily diagnosed infiltrative pulmonary tuberculosis underwent x-ray study. In patients with infiltration pulmonary tuberculosis CTSD in the lungs manifests by their diminishing, deformity of the lung pattern, high position of the diaphragm cupola, mediastinum shift to the side of the pathology, which is better seen on CT. The degree of CTSD x-ray signs in the lungs depends on the number of phenotypical signs that is the degree of the disease manifestation. CT allows more accurate determining of the signs of connective tissue dysplasia in which tuberculosis develops

  17. 29 CFR 780.607 - “Primarily employed” in agriculture.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false âPrimarily employedâ in agriculture. 780.607 Section 780... AGRICULTURE, PROCESSING OF AGRICULTURAL COMMODITIES, AND RELATED SUBJECTS UNDER THE FAIR LABOR STANDARDS ACT Employment in Agriculture and Livestock Auction Operations Under the Section 13(b)(13) Exemption Requirements...

  18. Hydrogen peroxide production is not primarily increased in human myotubes established from type 2 diabetic subjects.

    Science.gov (United States)

    Minet, A D; Gaster, M

    2011-09-01

    Increased oxidative stress and mitochondrial dysfunction have been implicated in the development of insulin resistance in type 2 diabetes. To date, it is unknown whether increased mitochondrial reactive oxygen species (ROS) production in skeletal muscle from patients with type 2 diabetes is primarily increased or a secondary adaptation to environmental, lifestyle, and hormonal factors. This study investigates whether ROS production is primarily increased in isolated diabetic myotubes. Mitochondrial membrane potential, hydrogen peroxide (H(2)O(2)), superoxide, and mitochondrial mass were determined in human myotubes precultured under normophysiological conditions. Furthermore, the corresponding ATP synthesis was measured in isolated mitochondria. Muscle biopsies were taken from 10 lean subjects, 10 obese subjects, and 10 subjects with type 2 diabetes; satellite cells were isolated, cultured, and differentiated to myotubes. Mitochondrial mass, membrane potential/mitochondrial mass, and superoxide-production/mitochondrial mass were not different between groups. In contrast, H(2)O(2) production/mitochondrial mass and ATP production were significantly reduced in diabetic myotubes compared to lean controls (P production is not primarily increased in diabetic myotubes but rather is reduced. Moreover, the comparable ATP/H(2)O(2) ratios indicate that the reduced ROS production in diabetic myotubes parallels the reduced ATP production because ROS production in diabetic myotubes must be considered to be in a proportion comparable to lean. Thus, the increased ROS production seen in skeletal muscle of type 2 diabetic patients is an adaptation to the in vivo conditions.

  19. Triacylglycerol Accumulation is not primarily affected in Myotubes established from Type 2 Diabetic Subjects

    DEFF Research Database (Denmark)

    Gaster, Michael; Beck-Nielsen, Henning

    2006-01-01

    In the present study, we investigated triacylglycerol (TAG) accumulation, glucose and fatty acid (FA) uptake, and glycogen synthesis (GS) in human myotubes from healthy, lean, and obese subjects with and without type 2 diabetes (T2D), exposed to increasing palmitate (PA) and oleate (OA...... uptake (P0.05). These results indicate that (1) TAG accumulation is not primarily affected in skeletal muscle tissue of obese and T2D; (2) induced inhibition of oxidative phosphorylation is followed by TAG accumulation...... in skeletal muscle of obese and T2D subjects is adaptive....

  20. Disgust sensitivity is primarily associated with purity-based moral judgments.

    Science.gov (United States)

    Wagemans, Fieke M A; Brandt, Mark J; Zeelenberg, Marcel

    2018-03-01

    Individual differences in disgust sensitivity are associated with a range of judgments and attitudes related to the moral domain. Some perspectives suggest that the association between disgust sensitivity and moral judgments will be equally strong across all moral domains (i.e., purity, authority, loyalty, care, fairness, and liberty). Other perspectives predict that disgust sensitivity is primarily associated with judgments of specific moral domains (e.g., primarily purity). However, no study has systematically tested if disgust sensitivity is associated with moral judgments of the purity domain specifically, more generally to moral judgments of the binding moral domains, or to moral judgments of all of the moral domains equally. Across 5 studies (total N = 1,104), we find consistent evidence for the notion that disgust sensitivity relates more strongly to moral condemnation of purity-based transgressions (meta-analytic r = .40) than to moral condemnation of transgressions of any of the other domains (range meta-analytic rs: .07-.27). Our findings are in line with predictions from Moral Foundations Theory, which predicts that personality characteristics like disgust sensitivity make people more sensitive to a certain set of moral issues. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  1. Lamin A/C mutation affecting primarily the right side of the heart

    Directory of Open Access Journals (Sweden)

    Laura Ollila

    2013-04-01

    Full Text Available LMNA mutations are amongst the most important causes of familial dilated cardiomyopathy. The most important cause of arrhythmogenic right ventricular cardiomyopathy (ARVC is desmosomal pathology. The aim of the study was to elucidate the role of LMNA mutations among Finnish cardiomyopathy patients. We screened 135 unrelated cardiomyopathy patients for LMNA mutations. Because of unusual phenotype, two patients were screened for the known Finnish ARVC-related mutations of desmosomal genes, and their Plakophilin-2b gene was sequenced. Myocardial samples from two patients were examined by immunohistochemical plakoglobin staining and in one case by electron microscopy. We found a new LMNA mutation Phe237Ser in a family of five affected members with a cardiomyopathy affecting primarily the right side of the heart. The phenotype resembles ARVC but does not fulfill the Task Force Criteria. The main clinical manifestations of the mutation were severe tricuspid insufficiency, right ventricular enlargement and failure. Three of the affected patients died of the heart disease, and the two living patients received heart transplants at ages 44 and 47. Electron microscopy showed nuclear blebbing compatible with laminopathy. Immunohisto - chemical analysis did not suggest desmosomal pathology. No desmosomal mutations were found. The Phe237Ser LMNA mutation causes a phenotype different from traditional cardiolaminopathy. Our findings suggest that cardiomyopathy affecting primarily the right side of the heart is not always caused by desmosomal pathology. Our observations highlight the challenges in classifying cardiomyopathies, as there often is significant overlap between the traditional categories.

  2. Direct healthcare costs of selected diseases primarily or partially transmitted by water.

    Science.gov (United States)

    Collier, S A; Stockman, L J; Hicks, L A; Garrison, L E; Zhou, F J; Beach, M J

    2012-11-01

    Despite US sanitation advancements, millions of waterborne disease cases occur annually, although the precise burden of disease is not well quantified. Estimating the direct healthcare cost of specific infections would be useful in prioritizing waterborne disease prevention activities. Hospitalization and outpatient visit costs per case and total US hospitalization costs for ten waterborne diseases were calculated using large healthcare claims and hospital discharge databases. The five primarily waterborne diseases in this analysis (giardiasis, cryptosporidiosis, Legionnaires' disease, otitis externa, and non-tuberculous mycobacterial infection) were responsible for over 40 000 hospitalizations at a cost of $970 million per year, including at least $430 million in hospitalization costs for Medicaid and Medicare patients. An additional 50 000 hospitalizations for campylobacteriosis, salmonellosis, shigellosis, haemolytic uraemic syndrome, and toxoplasmosis cost $860 million annually ($390 million in payments for Medicaid and Medicare patients), a portion of which can be assumed to be due to waterborne transmission.

  3. Temporal integration of loudness in listeners with hearing losses of primarily cochlear origin

    DEFF Research Database (Denmark)

    Buus, Søren; Florentine, Mary; Poulsen, Torben

    1999-01-01

    To investigate how hearing loss of primarily cochlear origin affects the loudness of brief tones, loudness matches between 5- and 200-ms tones were obtained as a function of level for 15 listeners with cochlear impairments and for seven age-matched controls. Three frequencies, usually 0.5, 1, and 4...... of temporal integration—defined as the level difference between equally loud short and long tones—varied nonmonotonically with level and was largest at moderate levels. No consistent effect of frequency was apparent. The impaired listeners varied widely, but most showed a clear effect of level on the amount...... of temporal integration. Overall, their results appear consistent with expectations based on knowledge of the general properties of their loudness-growth functions and the equal-loudness-ratio hypothesis, which states that the loudness ratio between equal-SPL long and brief tones is the same at all SPLs...

  4. The Serotonin Transporter Undergoes Constitutive Internalization and Is Primarily Sorted to Late Endosomes and Lysosomal Degradation*

    Science.gov (United States)

    Rahbek-Clemmensen, Troels; Bay, Tina; Eriksen, Jacob; Gether, Ulrik; Jørgensen, Trine Nygaard

    2014-01-01

    The serotonin transporter (SERT) plays a critical role in regulating serotonin signaling by mediating reuptake of serotonin from the extracellular space. The molecular and cellular mechanisms controlling SERT levels in the membrane remain poorly understood. To study trafficking of the surface resident SERT, two functional epitope-tagged variants were generated. Fusion of a FLAG-tagged one-transmembrane segment protein Tac to the SERT N terminus generated a transporter with an extracellular epitope suited for trafficking studies (TacSERT). Likewise, a construct with an extracellular antibody epitope was generated by introducing an HA (hemagglutinin) tag in the extracellular loop 2 of SERT (HA-SERT). By using TacSERT and HA-SERT in antibody-based internalization assays, we show that SERT undergoes constitutive internalization in a dynamin-dependent manner. Confocal images of constitutively internalized SERT demonstrated that SERT primarily co-localized with the late endosomal/lysosomal marker Rab7, whereas little co-localization was observed with the Rab11, a marker of the “long loop” recycling pathway. This sorting pattern was distinct from that of a prototypical recycling membrane protein, the β2-adrenergic receptor. Furthermore, internalized SERT co-localized with the lysosomal marker LysoTracker and not with transferrin. The sorting pattern was further confirmed by visualizing internalization of SERT using the fluorescent cocaine analog JHC1-64 and by reversible and pulse-chase biotinylation assays showing evidence for lysosomal degradation of the internalized transporter. Finally, we found that SERT internalized in response to stimulation with 12-myristate 13-acetate co-localized primarily with Rab7- and LysoTracker-positive compartments. We conclude that SERT is constitutively internalized and that the internalized transporter is sorted mainly to degradation. PMID:24973209

  5. The development and characterization of a primarily mineral calcium phosphate - poly(epsilon-caprolactone) biocomposite

    Science.gov (United States)

    Dunkley, Ian Robert

    Orthopaedic reconstruction often involves the surgical introduction of structural implants that provide for rigid fixation, skeletal stabilization, and bone integration. The high stresses incurred by these implanted devices have historically limited material choices to metallic and select polymeric formulations. While mechanical requirements are achieved, these non-degradable materials do not participate actively in the remodeling of the skeleton and present the possibility of long-term failure or rejection. This is particularly relevant in cervical fusion, an orthopaedic procedure to treat damaged, degenerative or diseased intervertebral discs. A significant improvement on the available synthetic bone replacement/regeneration options for implants to treat these conditions in the cervical spine may be achieved with the development of primarily mineral biocomposites comprised of a bioactive ceramic matrix reinforced with a biodegradable polymer. Such a biocomposite may be engineered to possess the clinically required mechanical properties of a particular application, while maintaining the ability to be remodeled completely by the body. A biocomposite of Si-doped calcium phosphate (Si-CaP) and poly(epsilon-caprolactone) (PCL) was developed for application as such a synthetic bone material for potential use as a fusion device in the cervical spine. In this thesis, a method by which high mineral content Si-CaP/PCL biocomposites with interpenetrating matrices of mineral and polymer phases may be prepared will be demonstrated, in addition to the effects of the various preparation parameters on the biocomposite density, porosity and mechanical properties. This new technique by which dense, primarily ceramic Si-CaP/PCL biocomposites were prepared, allowed for the incorporation of mineral contents ranging between 45-97vol%. Polymer infiltration, accomplished solely by passive capillary uptake over several days, was found to be capable of fully infiltrating the microporosity

  6. Efficient transfection of DNA into primarily cultured rat sertoli cells by electroporation.

    Science.gov (United States)

    Li, Fuping; Yamaguchi, Kohei; Okada, Keisuke; Matsushita, Kei; Enatsu, Noritoshi; Chiba, Koji; Yue, Huanxun; Fujisawa, Masato

    2013-03-01

    The expression of exogenous DNA in Sertoli cells is essential for studying its functional genomics, pathway analysis, and medical applications. Electroporation is a valuable tool for nucleic acid delivery, even in primarily cultured cells, which are considered difficult to transfect. In this study, we developed an optimized protocol for electroporation-based transfection of Sertoli cells and compared its efficiency with conventional lipofection. Sertoli cells were transfected with pCMV-GFP plasmid by square-wave electroporation under different conditions. After transfection of plasmid into Sertoli cells, enhanced green fluorescent protein (EGFP) expression could be easily detected by fluorescent microscopy, and cell survival was evaluated by dye exclusion assay using Trypan blue. In terms of both cell survival and the percentage expressing EGFP, 250 V was determined to produce the greatest number of transiently transfected cells. Keeping the voltage constant (250 V), relatively high cell survival (76.5% ± 3.4%) and transfection efficiency (30.6% ± 5.6%) were observed with a pulse length of 20 μm. The number of pulses significantly affected cell survival and EGFP expression (P transfection methods, the transfection efficiency of electroporation (21.5% ± 5.7%) was significantly higher than those of Lipofectamine 2000 (2.9% ± 1.0%) and Effectene (1.9% ± 0.8%) in this experiment (P transfection of Sertoli cells.

  7. Perceptions of Mindfulness in a Low-income, Primarily African American Treatment-Seeking Sample.

    Science.gov (United States)

    Spears, Claire Adams; Houchins, Sean C; Bamatter, Wendy P; Barrueco, Sandra; Hoover, Diana Stewart; Perskaudas, Rokas

    2017-12-01

    Individuals with low socioeconomic status (SES) and members of racial/ethnic minority groups often experience profound disparities in mental health and physical well-being. Mindfulness-based interventions show promise for improving mood and health behaviors in higher-SES and non-Latino White populations. However, research is needed to explore what types of adaptations, if any, are needed to best support underserved populations. This study used qualitative methods to gain information about a) perceptions of mindfulness, b) experiences with meditation, c) barriers to practicing mindfulness, and d) recommendations for tailoring mindfulness-based interventions in a low-income, primarily African American treatment-seeking sample. Eight focus groups were conducted with 32 adults (16 men and 16 women) currently receiving services at a community mental health center. Most participants (91%) were African American. Focus group data were transcribed and analyzed using NVivo 10. A team of coders reviewed the transcripts to identify salient themes. Relevant themes included beliefs that mindfulness practice might improve mental health (e.g., managing stress and anger more effectively) and physical health (e.g., improving sleep and chronic pain, promoting healthier behaviors). Participants also discussed ways in which mindfulness might be consistent with, and even enhance, their religious and spiritual practices. Results could be helpful in tailoring mindfulness-based treatments to optimize feasibility and effectiveness for low-SES adults receiving mental health services.

  8. Identification of a novel CoA synthase isoform, which is primarily expressed in Brain

    International Nuclear Information System (INIS)

    Nemazanyy, Ivan; Panasyuk, Ganna; Breus, Oksana; Zhyvoloup, Alexander; Filonenko, Valeriy; Gout, Ivan T.

    2006-01-01

    CoA and its derivatives Acetyl-CoA and Acyl-CoA are important players in cellular metabolism and signal transduction. CoA synthase is a bifunctional enzyme which mediates the final stages of CoA biosynthesis. In previous studies, we have reported molecular cloning, biochemical characterization, and subcellular localization of CoA synthase (CoASy). Here, we describe the existence of a novel CoA synthase isoform, which is the product of alternative splicing and possesses a 29aa extension at the N-terminus. We termed it CoASy β and originally identified CoA synthase, CoASy α. The transcript specific for CoASy β was identified by electronic screening and by RT-PCR analysis of various rat tissues. The existence of this novel isoform was further confirmed by immunoblot analysis with antibodies directed to the N-terminal peptide of CoASy β. In contrast to CoASy α, which shows ubiquitous expression, CoASy β is primarily expressed in Brain. Using confocal microscopy, we demonstrated that both isoforms are localized on mitochondria. The N-terminal extension does not affect the activity of CoA synthase, but possesses a proline-rich sequence which can bring the enzyme into complexes with signalling proteins containing SH3 or WW domains. The role of this novel isoform in CoA biosynthesis, especially in Brain, requires further elucidation

  9. GOLD HULL AND INTERNODE2 encodes a primarily multifunctional cinnamyl-alcohol dehydrogenase in rice.

    Science.gov (United States)

    Zhang, Kewei; Qian, Qian; Huang, Zejun; Wang, Yiqin; Li, Ming; Hong, Lilan; Zeng, Dali; Gu, Minghong; Chu, Chengcai; Cheng, Zhukuan

    2006-03-01

    Lignin content and composition are two important agronomic traits for the utilization of agricultural residues. Rice (Oryza sativa) gold hull and internode phenotype is a classical morphological marker trait that has long been applied to breeding and genetics study. In this study, we have cloned the GOLD HULL AND INTERNODE2 (GH2) gene in rice using a map-based cloning approach. The result shows that the gh2 mutant is a lignin-deficient mutant, and GH2 encodes a cinnamyl-alcohol dehydrogenase (CAD). Consistent with this finding, extracts from roots, internodes, hulls, and panicles of the gh2 plants exhibited drastically reduced CAD activity and undetectable sinapyl alcohol dehydrogenase activity. When expressed in Escherichia coli, purified recombinant GH2 was found to exhibit strong catalytic ability toward coniferaldehyde and sinapaldehyde, while the mutant protein gh2 completely lost the corresponding CAD and sinapyl alcohol dehydrogenase activities. Further phenotypic analysis of the gh2 mutant plants revealed that the p-hydroxyphenyl, guaiacyl, and sinapyl monomers were reduced in almost the same ratio compared to the wild type. Our results suggest GH2 acts as a primarily multifunctional CAD to synthesize coniferyl and sinapyl alcohol precursors in rice lignin biosynthesis.

  10. GOLD HULL AND INTERNODE2 Encodes a Primarily Multifunctional Cinnamyl-Alcohol Dehydrogenase in Rice1

    Science.gov (United States)

    Zhang, Kewei; Qian, Qian; Huang, Zejun; Wang, Yiqin; Li, Ming; Hong, Lilan; Zeng, Dali; Gu, Minghong; Chu, Chengcai; Cheng, Zhukuan

    2006-01-01

    Lignin content and composition are two important agronomic traits for the utilization of agricultural residues. Rice (Oryza sativa) gold hull and internode phenotype is a classical morphological marker trait that has long been applied to breeding and genetics study. In this study, we have cloned the GOLD HULL AND INTERNODE2 (GH2) gene in rice using a map-based cloning approach. The result shows that the gh2 mutant is a lignin-deficient mutant, and GH2 encodes a cinnamyl-alcohol dehydrogenase (CAD). Consistent with this finding, extracts from roots, internodes, hulls, and panicles of the gh2 plants exhibited drastically reduced CAD activity and undetectable sinapyl alcohol dehydrogenase activity. When expressed in Escherichia coli, purified recombinant GH2 was found to exhibit strong catalytic ability toward coniferaldehyde and sinapaldehyde, while the mutant protein gh2 completely lost the corresponding CAD and sinapyl alcohol dehydrogenase activities. Further phenotypic analysis of the gh2 mutant plants revealed that the p-hydroxyphenyl, guaiacyl, and sinapyl monomers were reduced in almost the same ratio compared to the wild type. Our results suggest GH2 acts as a primarily multifunctional CAD to synthesize coniferyl and sinapyl alcohol precursors in rice lignin biosynthesis. PMID:16443696

  11. Homogenous stretching or detachment faulting? Which process is primarily extending the Aegean crust

    Science.gov (United States)

    Kumerics, C.; Ring, U.

    2003-04-01

    In extending orogens like the Aegean Sea of Greece and the Basin-and-Range province of the western United States, knowledge of rates of tectonic processes are important for understanding which process is primarily extending the crust. Platt et al. (1998) proposed that homogeneous stretching of the lithosphere (i.e. vertical ductile thinning associated with a subhorizontal foliation) at rates of 4-5 km Myr-1 is the dominant process that formed the Alboran Sea in the western Mediterranean. The Aegean Sea in the eastern Mediterranean is well-known for its low-angle normal faults (detachments) (Lister et al., 1984; Lister &Forster, 1996) suggesting that detachment faulting may have been the primary agent achieving ~>250 km (McKenzie, 1978) of extension since the Miocene. Ring et al. (2003) provided evidence for a very fast-slipping detachment on the islands of Syros and Tinos in the western Cyclades, which suggests that normal faulting was the dominant tectonic process that formed the Aegean Sea. However, most extensional detachments in the Aegean do not allow to quantify the amount of vertical ductile thinning associated with extension and therefore a full evaluation of the significance of vertical ductile thinning is not possible. On the Island of Ikaria in the eastern Aegean Sea, a subhorizontal extensional ductile shear zone is well exposed. We studied this shear zone in detail to quantify the amount of vertical ductile thinning associated with extension. Numerous studies have shown that natural shear zones usually deviate significantly from progressive simple shear and are characterized by pronounced shortening perpendicular to the shear zone. Numerous deformed pegmatitic veins in this shear zone on Ikaria allow the reconstruction of deformation and flow parameters (Passchier, 1990), which are necessary for quantifying the amount of vertical ductile thinning in the shear zone. Furthermore, a flow-path and finite-strain study in a syn-tectonic granite, which

  12. Eningiomas: outcome, and analysis of prognostic factors of primarily resected tumors

    International Nuclear Information System (INIS)

    Stafford, S.L.; Perry, A.; Suman, V.; Meyer, B.; Scheithauer, B.W.; Shaw, E.G.; Earle, J.D.

    1996-01-01

    Purpose: 582 consecutive cases of primary intracranial meningioma undergoing resection at the Mayo Clinic, (Rochester, MN) were reviewed to determine overall survival (OS), progression free survival(PFS), prognostic factors predicting recurrence, and to determine the importance of radiation therapy in the management of this tumor. Materials and Methods: Between 1978-1988, 582 cases of primarily resected meningiomas were identified based on the tumor and operative registries where diagnosis was between 1978-1988 inclusive. PFS was identified by radiographic progression. Follow-up was accomplished by chart review, and a detailed questionnaire sent to patients and referring physicians. Estimation of OS and PFS distributions were done by the Kaplan-Meier method. The log rank test was used to assess which factors were associated with PFS. Proportional hazard modeling was performed to obtain a subset of independent predictors of PFS. Results: the median age was 57(5-93). 67% were female. CT identified the tumor in 91% of cases. There was associated edema in 21% and 2% were radiographically en plaque. There were 17 patients with multiple tumors, four of whom had a known diagnosis of neurofibromatosis. Gross total resection (GTR) was accomplished in 80%, radical subtotal or subtotal resection(STR) in 20%, and biopsy in 53) cellularity, and four or more mitoses per 10 HPF. Multivariate analysis indicated young age, male sex, en plaque at surgery, were significant for decreased PFS when only patient characteristics were considered. When treatment and pathologic factors were also considered, then young age, male sex, less than GTR, and tumor sheeting were predictors for decreased PFS. 10 patients had RT after initial resection, two of whom recurred. There were 107 first recurrences. 50 were observed(no intervention within 3 months), 35 treated by surgery alone, 11 had S+RT, and 11 were treated with RT alone. Considering those patients treated at recurrence (n=57), PFS was at

  13. Analysis of survival for patients with chronic kidney disease primarily related to renal cancer surgery.

    Science.gov (United States)

    Wu, Jitao; Suk-Ouichai, Chalairat; Dong, Wen; Antonio, Elvis Caraballo; Derweesh, Ithaar H; Lane, Brian R; Demirjian, Sevag; Li, Jianbo; Campbell, Steven C

    2018-01-01

    To evaluate predictors of long-term survival for patients with chronic kidney disease primarily due to surgery (CKD-S). Patients with CKD-S have generally good survival that approximates patients who do not have CKD even after renal cancer surgery (RCS), yet there may be heterogeneity within this cohort. From 1997 to 2008, 4 246 patients underwent RCS at our centre. The median (interquartile range [IQR]) follow-up was 9.4 (7.3-11.0) years. New baseline glomerular filtration rate (GFR) was defined as highest GFR between nadir and 6 weeks after RCS. We retrospectively evaluated three cohorts: no-CKD (new baseline GFR of ≥60 mL/min/1.73 m 2 ); CKD-S (new baseline GFR of cancer-related survival (NRCRS) for the CKD-S cohort. Kaplan-Meier analysis assessed the longitudinal impact of new baseline GFR (45-60 mL/min/1.73 m 2 vs <45 mL/min/1.73 m 2 ) and Cox regression evaluated relative impact of preoperative GFR, new baseline GFR, and relevant demographics/comorbidities. Of the 4 246 patients who underwent RCS, 931 had CKD-S and 1 113 had CKD-M/S, whilst 2 202 had no-CKD even after RCS. Partial/radical nephrectomy (PN/RN) was performed in 54%/46% of the patients, respectively. For CKD-S, 641 patients had a new baseline GFR of 45-60 mL/min/1.73 m 2 and 290 had a new baseline GFR of <45 mL/min/1.73 m 2 . Kaplan-Meier analysis showed significantly reduced NRCRS for patients with CKD-S with a GFR of <45 mL/min/1.73 m 2 compared to those with no-CKD or CKD-S with a GFR of 45-60 mL/min/1.73 m 2 (both P ≤ 0.004), and competing risk analysis confirmed this (P < 0.001). Age, gender, heart disease, and new baseline GFR were all associated independently with NRCRS for patients with CKD-S (all P ≤ 0.02). Our data suggest that CKD-S is heterogeneous, and patients with a reduced new baseline GFR have compromised survival, particularly if <45 mL/min/1.73 m 2 . Our findings may have implications regarding choice of PN/RN in patients at risk of developing

  14. Pyrrolizidine Alkaloids from Echium vulgare in Honey Originate Primarily from Floral Nectar.

    Science.gov (United States)

    Lucchetti, Matteo A; Glauser, Gaetan; Kilchenmann, Verena; Dübecke, Arne; Beckh, Gudrun; Praz, Christophe; Kast, Christina

    2016-06-29

    Pyrrolizidine alkaloids (PAs) in honey can be a potential human health risk. So far, it has remained unclear whether PAs in honey originate from pollen or floral nectar. We obtained honey, nectar, and plant pollen from two observation sites where Echium vulgare L. was naturally abundant. The PA concentration of honey was determined by targeted analysis using a high pressure liquid chromatography-mass spectrometry system (HPLC-MS/MS), allowing the quantification of six different PAs and PA-N-oxides present in E. vulgare. Echium-type PAs were detected up to 0.153 μg/g in honey. Nectar and plant pollen were analyzed by nontargeted analysis using ultrahigh pressure liquid chromatography-high resolution-mass spectrometry (UHPLC-HR-MS), allowing the detection of 10 alkaloids in small size samples. Echium-type PAs were detected between 0.3-95.1 μg/g in nectar and 500-35000 μg/g in plant pollen. The PA composition in nectar and plant pollen was compared to the composition in honey. Echimidine (+N-oxide) was the main alkaloid detected in honey and nectar samples, while echivulgarine (+N-oxide) was the main PA found in plant pollen. These results suggest that nectar contributes more significantly to PA contamination in honey than plant pollen.

  15. Microbial degradation of high nitrogen contents (primarily nitrate) in industrial waste water

    International Nuclear Information System (INIS)

    Claus, G.; Kutzner, H.J.

    1984-04-01

    This study deals with the denitrification of industrial waste water of high nitrate content, including waste water from the recovery process for nuclear material. At first the autotrophic process employing Thiob. denitrificans was investigated: kinetics, stoichiometry, application of a packed bed reactor; effect of nitrate concentration, retention time, loading and height of the reactor on denitrification. The system proved to be useful for waste water with nitrate up to 4.5 g/L; the highest rate of denitrification achieved was 1.5 g/L.h when the retention time was 2.5 h and the nitrate concentration (in-flow) 4.3 g/L (i.e. reactor loadung 41 kg NO 3 - /m 3 .d). Equally good results were obtained by the heterotrophic process: ethanol allowed a reactor loading of 60 kg NO 3 - /m 3 .d; however, in this case bacterial growth tended to clog the column. - Enrichments made with ethanol yielded Ps. aeruginosa as main component of the population; in contrast, those with methanol resulted in a mixture of Hyphomicrobium spec. and Paracoccus denitrificans; this bacterial culture was used to determine the stoichiometry of denitrification in continuous culture; it was also employed to denitrify a diluted solution of nitric acid (0.1 ml HNO 3 /L) which could be achieved in continuous culture using a retention time of 25 h. (orig.) [de

  16. CONFIRMING THE PRIMARILY SMOOTH STRUCTURE OF THE VEGA DEBRIS DISK AT MILLIMETER WAVELENGTHS

    Energy Technology Data Exchange (ETDEWEB)

    Hughes, A. Meredith; Plambeck, Richard; Chiang, Eugene [Department of Astronomy, University of California, Berkeley, CA 94720 (United States); Wilner, David J.; Andrews, Sean M. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Mason, Brian [National Radio Astronomy Observatory, 520 Edgemont Road, Charlottesville, VA 22903-2475 (United States); Carpenter, John M. [California Institute of Technology, Department of Astronomy, MC 105-24, Pasadena, CA 91125 (United States); Chiang, Hsin-Fang [Institute for Astronomy, University of Hawaii, 640 North Aohoku Place, Hilo, HI 96720 (United States); Williams, Jonathan P. [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States); Hales, Antonio [Joint ALMA Observatory, Av. El Golf 40, Piso 18, Santiago (Chile); Su, Kate [Steward Observatory, University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85721 (United States); Dicker, Simon; Korngut, Phil; Devlin, Mark, E-mail: mhughes@astro.berkeley.edu [Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, PA 19104 (United States)

    2012-05-01

    Clumpy structure in the debris disk around Vega has been previously reported at millimeter wavelengths and attributed to concentrations of dust grains trapped in resonances with an unseen planet. However, recent imaging at similar wavelengths with higher sensitivity has disputed the observed structure. We present three new millimeter-wavelength observations that help to resolve the puzzling and contradictory observations. We have observed the Vega system with the Submillimeter Array (SMA) at a wavelength of 880 {mu}m and an angular resolution of 5''; with the Combined Array for Research in Millimeter-wave Astronomy (CARMA) at a wavelength of 1.3 mm and an angular resolution of 5''; and with the Green Bank Telescope (GBT) at a wavelength of 3.3 mm and angular resolution of 10''. Despite high sensitivity and short baselines, we do not detect the Vega debris disk in either of the interferometric data sets (SMA and CARMA), which should be sensitive at high significance to clumpy structure based on previously reported observations. We obtain a marginal (3{sigma}) detection of disk emission in the GBT data; the spatial distribution of the emission is not well constrained. We analyze the observations in the context of several different models, demonstrating that the observations are consistent with a smooth, broad, axisymmetric disk with inner radius 20-100 AU and width {approx}> 50 AU. The interferometric data require that at least half of the 860 {mu}m emission detected by previous single-dish observations with the James Clerk Maxwell Telescope be distributed axisymmetrically, ruling out strong contributions from flux concentrations on spatial scales of {approx}<100 AU. These observations support recent results from the Plateau de Bure Interferometer indicating that previous detections of clumpy structure in the Vega debris disk were spurious.

  17. CONFIRMING THE PRIMARILY SMOOTH STRUCTURE OF THE VEGA DEBRIS DISK AT MILLIMETER WAVELENGTHS

    International Nuclear Information System (INIS)

    Hughes, A. Meredith; Plambeck, Richard; Chiang, Eugene; Wilner, David J.; Andrews, Sean M.; Mason, Brian; Carpenter, John M.; Chiang, Hsin-Fang; Williams, Jonathan P.; Hales, Antonio; Su, Kate; Dicker, Simon; Korngut, Phil; Devlin, Mark

    2012-01-01

    Clumpy structure in the debris disk around Vega has been previously reported at millimeter wavelengths and attributed to concentrations of dust grains trapped in resonances with an unseen planet. However, recent imaging at similar wavelengths with higher sensitivity has disputed the observed structure. We present three new millimeter-wavelength observations that help to resolve the puzzling and contradictory observations. We have observed the Vega system with the Submillimeter Array (SMA) at a wavelength of 880 μm and an angular resolution of 5''; with the Combined Array for Research in Millimeter-wave Astronomy (CARMA) at a wavelength of 1.3 mm and an angular resolution of 5''; and with the Green Bank Telescope (GBT) at a wavelength of 3.3 mm and angular resolution of 10''. Despite high sensitivity and short baselines, we do not detect the Vega debris disk in either of the interferometric data sets (SMA and CARMA), which should be sensitive at high significance to clumpy structure based on previously reported observations. We obtain a marginal (3σ) detection of disk emission in the GBT data; the spatial distribution of the emission is not well constrained. We analyze the observations in the context of several different models, demonstrating that the observations are consistent with a smooth, broad, axisymmetric disk with inner radius 20-100 AU and width ∼> 50 AU. The interferometric data require that at least half of the 860 μm emission detected by previous single-dish observations with the James Clerk Maxwell Telescope be distributed axisymmetrically, ruling out strong contributions from flux concentrations on spatial scales of ∼<100 AU. These observations support recent results from the Plateau de Bure Interferometer indicating that previous detections of clumpy structure in the Vega debris disk were spurious.

  18. Ah receptor mediated suppression of the antibody response in mice is primarily dependent on the Ah phenotype of lymphoid tissue

    International Nuclear Information System (INIS)

    Silkworth, J.B.; Antrim, L.A.; Sack, G.

    1986-01-01

    Halogenated aromatic hydrocarbons act through the aromatic hydrocarbon (Ah) receptor in mice to produce a series of toxic effects of the immune system. The receptor protein is a product of the Ah gene locus. Ah responsive (Ahb/Ahb) mice express a high affinity receptor in both lymphoid and nonlymphoid tissues whereas nonresponsive Ahd/Ahd mice express a poor affinity receptor. To determine the role of the Ah receptor of lymphoid tissue relative to that of nonlymphoid tissue in the induction of immune impairment, bone marrow was used to reconstitute lethally irradiated mice of the same or opposite Ah phenotype. All mice were given 3,3',4,4'-tetrachlorobiphenyl (35 and 350 mumol/kg) ip 2 days before immunization with sheep erythrocytes (SRBC). The immune response to this T dependent antigen and organ weights were determined 5 or 7 days later in normal or chimeric mice, respectively. Monoclonal Lyt 1.1 and Lyt 1.2 antibodies were used to establish the origin of the cells which repopulated the chimeric thymuses. The immune responses of both BALB/cBy (Ahb/Ahb) and the BALB/cBy X DBA/2 hybrid, CByD2F1 (Ahb/Ahd), were significantly suppressed but DBA/2 mice were unaffected. The immune responses of chimeric BALB/cBy----BALB/cBy and BALB/cBy----DBA/2 (donor----recipient) mice were also significantly suppressed and thymic atrophy was observed in both cases. The serum anti-SRBC antibody titers of DBA/2----BALB/cBy chimeras were also significantly decreased although not to the same extent as in BALB/cBy----DBA/2 mice. Chimeric DBA/2----DBA/2 mice were not affected. These results indicate that the sensitivity to Ah receptor mediated suppression of the antibody response is primarily determined by the Ah phenotype of the lymphoid tissue

  19. Inward Rectifier K+ Currents Are Regulated by CaMKII in Endothelial Cells of Primarily Cultured Bovine Pulmonary Arteries.

    Science.gov (United States)

    Qu, Lihui; Yu, Lei; Wang, Yanli; Jin, Xin; Zhang, Qianlong; Lu, Ping; Yu, Xiufeng; Zhong, Weiwei; Zheng, Xiaodong; Cui, Ningren; Jiang, Chun; Zhu, Daling

    2015-01-01

    Endothelium lines the interior surface of vascular walls and regulates vascular tones. The endothelial cells sense and respond to chemical and mechanical stimuli in the circulation, and couple the stimulus signals to vascular smooth muscles, in which inward rectifier K+ currents (Kir) play an important role. Here we applied several complementary strategies to determine the Kir subunit in primarily cultured pulmonary arterial endothelial cells (PAECs) that was regulated by the Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII). In whole-cell voltage clamp, the Kir currents were sensitive to micromolar concentrations of extracellular Ba2+. In excised inside-out patches, an inward rectifier K+ current was observed with single-channel conductance 32.43 ± 0.45 pS and Popen 0.27 ± 0.04, which were consistent with known unitary conductance of Kir 2.1. RT-PCR and western blot results showed that expression of Kir 2.1 was significantly stronger than that of other subtypes in PAECs. Pharmacological analysis of the Kir currents demonstrated that insensitivity to intracellular ATP, pinacidil, glibenclamide, pH, GDP-β-S and choleratoxin suggested that currents weren't determined by KATP, Kir2.3, Kir2.4 and Kir3.x. The currents were strongly suppressed by exposure to CaMKII inhibitor W-7 and KN-62. The expression of Kir2.1 was inhibited by knocking down CaMKII. Consistently, vasodilation was suppressed by Ba2+, W-7 and KN-62 in isolated and perfused pulmonary arterial rings. These results suggest that the PAECs express an inward rectifier K+ current that is carried dominantly by Kir2.1, and this K+ channel appears to be targeted by CaMKII-dependent intracellular signaling systems.

  20. Inward Rectifier K+ Currents Are Regulated by CaMKII in Endothelial Cells of Primarily Cultured Bovine Pulmonary Arteries.

    Directory of Open Access Journals (Sweden)

    Lihui Qu

    Full Text Available Endothelium lines the interior surface of vascular walls and regulates vascular tones. The endothelial cells sense and respond to chemical and mechanical stimuli in the circulation, and couple the stimulus signals to vascular smooth muscles, in which inward rectifier K+ currents (Kir play an important role. Here we applied several complementary strategies to determine the Kir subunit in primarily cultured pulmonary arterial endothelial cells (PAECs that was regulated by the Ca2+/calmodulin (CaM-dependent protein kinase II (CaMKII. In whole-cell voltage clamp, the Kir currents were sensitive to micromolar concentrations of extracellular Ba2+. In excised inside-out patches, an inward rectifier K+ current was observed with single-channel conductance 32.43 ± 0.45 pS and Popen 0.27 ± 0.04, which were consistent with known unitary conductance of Kir 2.1. RT-PCR and western blot results showed that expression of Kir 2.1 was significantly stronger than that of other subtypes in PAECs. Pharmacological analysis of the Kir currents demonstrated that insensitivity to intracellular ATP, pinacidil, glibenclamide, pH, GDP-β-S and choleratoxin suggested that currents weren't determined by KATP, Kir2.3, Kir2.4 and Kir3.x. The currents were strongly suppressed by exposure to CaMKII inhibitor W-7 and KN-62. The expression of Kir2.1 was inhibited by knocking down CaMKII. Consistently, vasodilation was suppressed by Ba2+, W-7 and KN-62 in isolated and perfused pulmonary arterial rings. These results suggest that the PAECs express an inward rectifier K+ current that is carried dominantly by Kir2.1, and this K+ channel appears to be targeted by CaMKII-dependent intracellular signaling systems.

  1. Examining Change in K-3 Teachers' Mathematical Knowledge, Attitudes, and Beliefs: The Case of Primarily Math

    Science.gov (United States)

    Kutaka, T. S.; Ren, L.; Smith, W. M.; Beattie, H. L.; Edwards, C. P.; Green, J. L.; Chernyavskiy, P.; Stroup, W.; Heaton, R. M.; Lewis, W. J.

    2018-01-01

    This study examines the impact of the Primarily Math Elementary Mathematics Specialist program on K-3 teachers' mathematical content knowledge for teaching, attitudes toward learning mathematics, and beliefs about mathematics teaching and learning. Three cohorts of teachers participating in the program were compared to a similar group of…

  2. Assessment of Vegetation Variation on Primarily Creation Zones of the Dust Storms Around the Euphrates Using Remote Sensing Images

    Directory of Open Access Journals (Sweden)

    Jamil Amanollahi

    2012-06-01

    Full Text Available Recently, period frequency and effect domain of the dust storms that enter Iran from Iraq have increased. In this study, in addition to detecting the creation zones of the dust storms, the effect of vegetation cover variation on their creation was investigated using remote sensing. Moderate resolution image Spectroradiometer (MODIS and Landsat Thematic Mapper (TM5 have been utilized to identify the primarily creation zones of the dust storms and to assess the vegetation cover variation, respectively. Vegetation cover variation was studied using Normalized Differences Vegetation Index (NDVI obtained from band 3 and band 4 of the Landsate satellite. The results showed that the surrounding area of the Euphrates in Syria, the desert in the vicinity of this river in Iraq, including the deserts of Alanbar Province, and the north deserts of Saudi Arabia are the primarily creation zones of the dust storms entering west and south west of Iran. The results of NDVI showed that excluding the deserts in the border of Syria and Iraq, the area with very weak vegetation cover have increased between 2.44% and 20.65% from 1991 to 2009. In the meanwhile, the retention pound surface areas in the south deserts of Syria as well as the deserts in its border with Iraq have decreased 6320 and 4397 hectares, respectively. As it can be concluded from the findings, one of the main environmental parameters initiating these dust storms is the decrease in the vegetation cover in their primarily creation zones.

  3. FADD Expression as a Prognosticator in Early-Stage Glottic Squamous Cell Carcinoma of the Larynx Treated Primarily With Radiotherapy

    International Nuclear Information System (INIS)

    Schrijvers, Michiel L.; Pattje, Wouter J.; Slagter-Menkema, Lorian; Mastik, Mirjam F.; Gibcus, Johan H.; Langendijk, Johannes A.; Wal, Jacqueline E. van der; Laan, Bernard F.A.M. vn der; Schuuring, E.

    2012-01-01

    Purpose: We recently reported on the identification of the Fas-associated death domain (FADD) as a possible driver of the chromosome 11q13 amplicon and the association between increased FADD expression and disease-specific survival in advanced-stage laryngeal carcinoma. The aim of this study was to examine whether expression of FADD and its Ser194-phosphorylated isoform (pFADD) predicts local control in patients with early-stage glottic carcinoma primarily treated with radiotherapy only. Methods and Materials: Immunohistochemical staining for FADD and pFADD was performed on pretreatment biopsy specimens of 92 patients with T1–T2 glottic squamous cell carcinoma primarily treated with radiotherapy between 1996 and 2005. Cox regression analysis was used to correlate expression levels with local control. Results: High levels of pFADD were associated with significantly better local control (hazard ratio, 2.40; 95% confidence interval, 1.04–5.55; p = 0.040). FADD overexpression showed a trend toward better local control (hazard ratio, 3.656; 95% confidence interval, 0.853–15.663; p = 0.081). Multivariate Cox regression analysis showed that high pFADD expression was the best predictor of local control after radiotherapy. Conclusions: This study showed that expression of phosphorylated FADD is a new prognostic biomarker for better local control after radiotherapy in patients with early-stage glottic carcinomas.

  4. Accumulation of a poly(hydroxyalkanoate) copolymer containing primarily 3-hydroxyvalerate from simple carbohydrate substrates by Rhodococcus sp. NCIMB 40126.

    Science.gov (United States)

    Haywood, G W; Anderson, A J; Williams, D R; Dawes, E A; Ewing, D F

    1991-04-01

    A number of taxonomically-related bacteria have been identified which accumulate poly(hydroxyalkanoate) (PHA) copolymers containing primarily 3-hydroxyvalerate (3HV) monomer units from a range of unrelated single carbon sources. One of these, Rhodococcus sp. NCIMB 40126, was further investigated and shown to produce a copolymer containing 75 mol% 3HV and 25 mol% 3-hydroxybutyrate (3HB) from glucose as sole carbon source. Polyesters containing both 3HV and 3HB monomer units, together with 4-hydroxybutyrate (4HB), 5-hydroxyvalerate (5HV) or 3-hydroxyhexanoate (3HHx), were also produced by this organism from certain accumulation substrates. With valeric acid as substrate, almost pure (99 mol% 3HV) poly(3-hydroxyvalerate) was produced. N.m.r. analysis confirmed the composition of these polyesters. The thermal properties and molecular weight of the copolymer produced from glucose were comparable to those of PHB produced by Alcaligenes eutrophus.

  5. Gender, Sexual Orientation, and Rape Myth Acceptance: Preliminary Findings From a Sample of Primarily LGBQ-Identified Survey Respondents.

    Science.gov (United States)

    Schulze, Corina; Koon-Magnin, Sarah

    2017-02-01

    This study is among the first to examine the relationship between sexual orientation and rape myth adherence using a nationwide survey of primarily lesbian, gay, bisexual, and queer (LGBQ) respondents (n = 184). The more established Illinois Rape Myth Acceptance Scale and a modified Male Rape Survey serve as the primary instruments to test both rape myth adherence and instrument-appropriateness. Results suggest that respondents were most likely to support myths that discredit sexual assault allegations or excuse rape as a biological imperative and least likely to support myths related to physical resistance. Consistent with previous work, men exhibited higher levels of rape myth adherence than women. Regarding sexual orientation, respondents who identified as queer consistently exhibited lower levels of rape myth adherence than respondents who identified as gay.

  6. Multi-Province Listeriosis Outbreak Linked to Contaminated Deli Meat Consumed Primarily in Institutional Settings, Canada, 2008.

    Science.gov (United States)

    Currie, Andrea; Farber, Jeffrey M; Nadon, Céline; Sharma, Davendra; Whitfield, Yvonne; Gaulin, Colette; Galanis, Eleni; Bekal, Sadjia; Flint, James; Tschetter, Lorelee; Pagotto, Franco; Lee, Brenda; Jamieson, Fred; Badiani, Tina; MacDonald, Diane; Ellis, Andrea; May-Hadford, Jennifer; McCormick, Rachel; Savelli, Carmen; Middleton, Dean; Allen, Vanessa; Tremblay, Francois-William; MacDougall, Laura; Hoang, Linda; Shyng, Sion; Everett, Doug; Chui, Linda; Louie, Marie; Bangura, Helen; Levett, Paul N; Wilkinson, Krista; Wylie, John; Reid, Janet; Major, Brian; Engel, Dave; Douey, Donna; Huszczynski, George; Di Lecci, Joe; Strazds, Judy; Rousseau, Josée; Ma, Kenneth; Isaac, Leah; Sierpinska, Urszula

    2015-08-01

    A multi-province outbreak of listeriosis occurred in Canada from June to November 2008. Fifty-seven persons were infected with 1 of 3 similar outbreak strains defined by pulsed-field gel electrophoresis, and 24 (42%) individuals died. Forty-one (72%) of 57 individuals were residents of long-term care facilities or hospital inpatients during their exposure period. Descriptive epidemiology, product traceback, and detection of the outbreak strains of Listeria monocytogenes in food samples and the plant environment confirmed delicatessen meat manufactured by one establishment and purchased primarily by institutions was the source of the outbreak. The food safety investigation identified a plant environment conducive to the introduction and proliferation of L. monocytogenes and persistently contaminated with Listeria spp. This outbreak demonstrated the need for improved listeriosis surveillance, strict control of L. monocytogenes in establishments producing ready-to-eat foods, and advice to vulnerable populations and institutions serving these populations regarding which high-risk foods to avoid.

  7. Development and Sensitivity Analysis of a Frost Risk model based primarily on freely distributed Earth Observation data

    Science.gov (United States)

    Louka, Panagiota; Petropoulos, George; Papanikolaou, Ioannis

    2015-04-01

    The ability to map the spatiotemporal distribution of extreme climatic conditions, such as frost, is a significant tool in successful agricultural management and decision making. Nowadays, with the development of Earth Observation (EO) technology, it is possible to obtain accurately, timely and in a cost-effective way information on the spatiotemporal distribution of frost conditions, particularly over large and otherwise inaccessible areas. The present study aimed at developing and evaluating a frost risk prediction model, exploiting primarily EO data from MODIS and ASTER sensors and ancillary ground observation data. For the evaluation of our model, a region in north-western Greece was selected as test site and a detailed sensitivity analysis was implemented. The agreement between the model predictions and the observed (remotely sensed) frost frequency obtained by MODIS sensor was evaluated thoroughly. Also, detailed comparisons of the model predictions were performed against reference frost ground observations acquired from the Greek Agricultural Insurance Organization (ELGA) over a period of 10-years (2000-2010). Overall, results evidenced the ability of the model to produce reasonably well the frost conditions, following largely explainable patterns in respect to the study site and local weather conditions characteristics. Implementation of our proposed frost risk model is based primarily on satellite imagery analysis provided nowadays globally at no cost. It is also straightforward and computationally inexpensive, requiring much less effort in comparison for example to field surveying. Finally, the method is adjustable to be potentially integrated with other high resolution data available from both commercial and non-commercial vendors. Keywords: Sensitivity analysis, frost risk mapping, GIS, remote sensing, MODIS, Greece

  8. Healthy younger and older adults control foot placement to avoid small obstacles during gait primarily by modulating step width

    Directory of Open Access Journals (Sweden)

    Schulz Brian W

    2012-10-01

    Full Text Available Abstract Background Falls are a significant problem in the older population. Most falls occur during gait, which is primarily regulated by foot placement. Variability of foot placement has been associated with falls, but these associations are inconsistent and generally for smooth, level flooring. This study investigates the control of foot placement and the associated gait variability in younger and older men and women (N=7/group, total N=28 while walking at three different speeds (slow, preferred, and fast across a control surface with no obstacles and surfaces with multiple (64 small (10cm long ×13mm high visible and hidden obstacles. Results Minimum obstacle distance between the shoe and nearest obstacle during each footfall was greater on the visible obstacles surface for older subjects because some of them chose to actively avoid obstacles. This obstacle avoidance strategy was implemented primarily by modulating step width and to a lesser extent step length as indicated by linear regressions of step width and length variability on minimum obstacle distance. Mean gait speed, step length, step width, and step time did not significantly differ by subject group, flooring surface, or obstacle avoidance strategy. Conclusions Some healthy older subjects choose to actively avoid small obstacles that do not substantially perturb their gait by modulating step width and, to a lesser extent, step length. It is not clear if this obstacle avoidance strategy is appropriate and beneficial or overcautious and maladaptive, as it results in fewer obstacles encountered at a consequence of a less efficient gait pattern that has been shown to indicate increased fall risk. Further research is needed on the appropriateness of strategy selection when the environmental demands and/or task requirements have multiple possible completion strategies with conflicting objectives (i.e. perceived safety vs. efficiency.

  9. Adolescent Pornography Use and Dating Violence among a Sample of Primarily Black and Hispanic, Urban-Residing, Underage Youth

    Directory of Open Access Journals (Sweden)

    Emily F. Rothman

    2015-12-01

    Full Text Available This cross-sectional study was designed to characterize the pornography viewing preferences of a sample of U.S.-based, urban-residing, economically disadvantaged, primarily Black and Hispanic youth (n = 72, and to assess whether pornography use was associated with experiences of adolescent dating abuse (ADA victimization. The sample was recruited from a large, urban, safety net hospital, and participants were 53% female, 59% Black, 19% Hispanic, 14% Other race, 6% White, and 1% Native American. All were 16–17 years old. More than half (51% had been asked to watch pornography together by a dating or sexual partner, and 44% had been asked to do something sexual that a partner saw in pornography. Adolescent dating abuse (ADA victimization was associated with more frequent pornography use, viewing pornography in the company of others, being asked to perform a sexual act that a partner first saw in pornography, and watching pornography during or after marijuana use. Approximately 50% of ADA victims and 32% of non-victims reported that they had been asked to do a sexual act that their partner saw in pornography (p = 0.15, and 58% did not feel happy to have been asked. Results suggest that weekly pornography use among underage, urban-residing youth is common, and may be associated with ADA victimization.

  10. Adolescent Pornography Use and Dating Violence among a Sample of Primarily Black and Hispanic, Urban-Residing, Underage Youth

    Science.gov (United States)

    Rothman, Emily F.; Adhia, Avanti

    2015-01-01

    This cross-sectional study was designed to characterize the pornography viewing preferences of a sample of U.S.-based, urban-residing, economically disadvantaged, primarily Black and Hispanic youth (n = 72), and to assess whether pornography use was associated with experiences of adolescent dating abuse (ADA) victimization. The sample was recruited from a large, urban, safety net hospital, and participants were 53% female, 59% Black, 19% Hispanic, 14% Other race, 6% White, and 1% Native American. All were 16–17 years old. More than half (51%) had been asked to watch pornography together by a dating or sexual partner, and 44% had been asked to do something sexual that a partner saw in pornography. Adolescent dating abuse (ADA) victimization was associated with more frequent pornography use, viewing pornography in the company of others, being asked to perform a sexual act that a partner first saw in pornography, and watching pornography during or after marijuana use. Approximately 50% of ADA victims and 32% of non-victims reported that they had been asked to do a sexual act that their partner saw in pornography (p = 0.15), and 58% did not feel happy to have been asked. Results suggest that weekly pornography use among underage, urban-residing youth may be common, and may be associated with ADA victimization. PMID:26703744

  11. Predictors of moderated drinking in a primarily alcohol dependent sample of men who have sex with men

    Science.gov (United States)

    Kuerbis, Alexis; Morgenstern, Jon; Hail, Lisa

    2012-01-01

    Understanding for whom moderated drinking is a viable, achievable, and sustainable goal among those with a range of alcohol use disorders (AUD) remains an important public health question. Despite common acceptance as severe risk factors, there is little empirical evidence to conclude whether co-occurring mental health disorders or drug dependence contribute to an individual’s inability to successfully moderate his drinking. Utilizing secondary data analysis, the purpose of this study was to identify predictors of moderation among both treatment seeking and non-treatment seeking, primarily alcohol dependent, problem drinking men who have sex with men (MSM), with an emphasis on the high risk factors psychiatric comorbidity and drug dependence. Problem drinkers (N=187) were assessed, provided feedback about their drinking, given the option to receive brief AUD treatment or change their drinking on their own, and then followed for 15 months. Findings revealed that neither psychiatric comorbidity or drug dependence predicted ability to achieve moderation when controlling for alcohol dependence severity. Those who were younger, more highly educated, and had more mild alcohol dependence were more likely to achieve moderated drinking. Impact of treatment on predictors is explored. Limitations of this study and arenas for future research are discussed. PMID:22201219

  12. Diet Quality and Nutrient Intake of Urban Overweight and Obese Primarily African American Older Adults with Osteoarthritis

    Directory of Open Access Journals (Sweden)

    Sevasti Vergis

    2018-04-01

    Full Text Available Diet quality may be a unique target for preventing and managing obesity-related osteoarthritis (OA. Using the Healthy Eating Index-2010 (HEI-2010, this study examined the nutrient intake and diet quality of 400 urban overweight and obese primarily African American older adults with self-reported lower extremity OA. Associations between sociodemographic and health-related factors and diet quality were explored. Participants (mean age 67.8 years, SD 5.9 were included. Habitual dietary intake was assessed using a food frequency questionnaire (FFQ. Nutrient intake and diet quality were calculated from the FFQ. Results indicated that diet quality needs improvement (HEI-2010: 66.3 (SD 10.5. Age, body mass index, employment (multivariable model only, and OA severity (bivariate model only were significant predictors of HEI-2010 total score in linear models. Mean intakes for fiber, calcium, and vitamin D were below recommendations, while percentage of calories as total fat exceeded recommendations. These findings can inform future dietary intervention trials and public health messaging for a sub-population at a high risk for obesity-related OA.

  13. Y-Chromosomal Diversity in Europe Is Clinal and Influenced Primarily by Geography, Rather than by Language

    Science.gov (United States)

    Rosser, Zoë H.; Zerjal, Tatiana; Hurles, Matthew E.; Adojaan, Maarja; Alavantic, Dragan; Amorim, António; Amos, William; Armenteros, Manuel; Arroyo, Eduardo; Barbujani, Guido; Beckman, Gunhild; Beckman, Lars; Bertranpetit, Jaume; Bosch, Elena; Bradley, Daniel G.; Brede, Gaute; Cooper, Gillian; Côrte-Real, Helena B. S. M.; de Knijff, Peter; Decorte, Ronny; Dubrova, Yuri E.; Evgrafov, Oleg; Gilissen, Anja; Glisic, Sanja; Gölge, Mukaddes; Hill, Emmeline W.; Jeziorowska, Anna; Kalaydjieva, Luba; Kayser, Manfred; Kivisild, Toomas; Kravchenko, Sergey A.; Krumina, Astrida; Kučinskas, Vaidutis; Lavinha, João; Livshits, Ludmila A.; Malaspina, Patrizia; Maria, Syrrou; McElreavey, Ken; Meitinger, Thomas A.; Mikelsaar, Aavo-Valdur; Mitchell, R. John; Nafa, Khedoudja; Nicholson, Jayne; Nørby, Søren; Pandya, Arpita; Parik, Jüri; Patsalis, Philippos C.; Pereira, Luísa; Peterlin, Borut; Pielberg, Gerli; Prata, Maria João; Previderé, Carlo; Roewer, Lutz; Rootsi, Siiri; Rubinsztein, D. C.; Saillard, Juliette; Santos, Fabrício R.; Stefanescu, Gheorghe; Sykes, Bryan C.; Tolun, Aslihan; Villems, Richard; Tyler-Smith, Chris; Jobling, Mark A.

    2000-01-01

    Clinal patterns of autosomal genetic diversity within Europe have been interpreted in previous studies in terms of a Neolithic demic diffusion model for the spread of agriculture; in contrast, studies using mtDNA have traced many founding lineages to the Paleolithic and have not shown strongly clinal variation. We have used 11 human Y-chromosomal biallelic polymorphisms, defining 10 haplogroups, to analyze a sample of 3,616 Y chromosomes belonging to 47 European and circum-European populations. Patterns of geographic differentiation are highly nonrandom, and, when they are assessed using spatial autocorrelation analysis, they show significant clines for five of six haplogroups analyzed. Clines for two haplogroups, representing 45% of the chromosomes, are continentwide and consistent with the demic diffusion hypothesis. Clines for three other haplogroups each have different foci and are more regionally restricted and are likely to reflect distinct population movements, including one from north of the Black Sea. Principal-components analysis suggests that populations are related primarily on the basis of geography, rather than on the basis of linguistic affinity. This is confirmed in Mantel tests, which show a strong and highly significant partial correlation between genetics and geography but a low, nonsignificant partial correlation between genetics and language. Genetic-barrier analysis also indicates the primacy of geography in the shaping of patterns of variation. These patterns retain a strong signal of expansion from the Near East but also suggest that the demographic history of Europe has been complex and influenced by other major population movements, as well as by linguistic and geographic heterogeneities and the effects of drift. PMID:11078479

  14. Social Media Use and its Association with Sexual Risk and Parental Monitoring among a Primarily Hispanic Adolescent Population.

    Science.gov (United States)

    Romo, Dina L; Garnett, Chelsea; Younger, Alayna P; Stockwell, Melissa S; Soren, Karen; Catallozzi, Marina; Neu, Natalie

    2017-08-01

    In this study we assessed the association between social media (SM) use with sexual risk, and with parental monitoring among Hispanic adolescents. Self-administered anonymous survey. Urban primary care clinics. Primarily Hispanic adolescents ages 13-21 years old. Chi-square and regression analyses controlling for age and gender were used to assess associations between SM use or sexting and sexual behaviors (kissing, touching genitals, vaginal oral, and anal sex), sexual risk (≥4 lifetime partners, >1 recent partner, inconsistent condom use, and history of sexually transmitted infection diagnosis) and contraceptive use. Similar analyses were used to assess relationships between adolescent-reported parental monitoring and SM use, and sexting. Participants with frequent SM use (social networking sites or apps) had greater odds of all sexual activity. Ever sexters had greater odds of penetrative sex only (oral, vaginal, and anal sex) as well as use of hormonal contraception (except long-acting reversible contraception). Approximately half of the participants reported parental access to profiles on SM. Female participants had higher odds of parental access to online profiles and having a parental discussion of privacy settings. Those having privacy discussions had greater odds of "private" profiles on SM and lower odds of ever sexting. Frequent SM use and sexting was associated with an increase in all types of sexual behaviors; sexting alone was associated with more lifetime and recent sexual partners. Parental discussion of privacy settings was found to be protective. Providers and parents should be aware of the effect of SM use on sexual behaviors. Copyright © 2017 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

  15. 49 CFR 37.195 - Purchase or lease of OTRBs by private entities not primarily in the business of transporting people.

    Science.gov (United States)

    2010-10-01

    ... primarily in the business of transporting people. 37.195 Section 37.195 Transportation Office of the... transporting people. This section applies to all purchases or leases of new vehicles by private entities which are not primarily engaged in the business of transporting people, with respect to buses delivered to...

  16. 50 CFR 23.62 - What factors are considered in making a finding of not for primarily commercial purposes?

    Science.gov (United States)

    2010-10-01

    ..., SALE, PURCHASE, BARTER, EXPORTATION, AND IMPORTATION OF WILDLIFE AND PLANTS (CONTINUED) CONVENTION ON... from a licensed, independent certified public accountant that the internal accounting system is...

  17. TRPA1 is functionally expressed primarily by IB4-binding, non-peptidergic mouse and rat sensory neurons.

    Directory of Open Access Journals (Sweden)

    Marie E Barabas

    functionally expressed primarily in the IB4-positive, CGRP-negative subpopulation of small lumbar DRG neurons from rodents. Thus, IB4 binding is a better indicator than neuropeptides for TRPA1 expression.

  18. TRPA1 Is Functionally Expressed Primarily by IB4-Binding, Non-Peptidergic Mouse and Rat Sensory Neurons

    Science.gov (United States)

    Stucky, Cheryl L.

    2012-01-01

    primarily in the IB4-positive, CGRP-negative subpopulation of small lumbar DRG neurons from rodents. Thus, IB4 binding is a better indicator than neuropeptides for TRPA1 expression. PMID:23133534

  19. Hydroa vacciniforme-like lymphoma with primarily periorbital swelling: 7 cases of an atypical clinical manifestation of this rare cutaneous T-cell lymphoma.

    Science.gov (United States)

    Plaza, Jose A; Sangueza, Martin

    2015-01-01

    Hydroa vacciniforme-like lymphoma (HVL) is a rare cutaneous T-cell lymphoma that is usually seen in children of Hispanic or Asian origin. Association between chronic latent Epstein-Barr virus infection in both hydroa vacciniforme (HV) and HVL has been demonstrated and has recently been categorized by the World Health Organization as one of the Epstein Barr virus-positive lymphoproliferative disorders of childhood. Patients with HVL present with a cutaneous rash characterized by edema, blisters, ulcers, and scars mainly seen on the face and extremities that mimic HV; however, unlike in HV, the lesions tend to be extensive and deeper and are associated with severe scarring, necrosis, and systemic manifestations. We are reporting 7 cases of an unusual clinical variant of HVL with primarily periorbital edema. All of our patients in this series presented with progressive periorbital edema that was accompanied with systemic symptoms including fever, malaise, and lymphadenopathy. Most cases were initially misinterpreted as inflammatory processes including cellulitis, arthropod bite reactions, and periorbital lupus erythematosus. The biopsy of these lesions revealed an atypical lymphocytic infiltrate predominantly distributed in the deep dermis and in subcutaneous fat. Immunohistochemistry studies revealed a cytotoxic T-cell (CD8) profile. All cases were associated with Epstein-Barr virus infection. Our study presents a rare clinical variant of HVL with predominant periorbital edema. This variant could potentially be overlooked and misdiagnosed as an inflammatory condition; thus, it needs to be included in the differential diagnosis of periorbital edema in young patients.

  20. Chlamydia trachomatis recombinant MOMP encapsulated in PLGA nanoparticles triggers primarily T helper 1 cellular and antibody immune responses in mice: a desirable candidate nanovaccine

    Directory of Open Access Journals (Sweden)

    Fairley SJ

    2013-05-01

    Full Text Available Stacie J Fairley, Shree R Singh, Abebayehu N Yilma, Alain B Waffo, Praseetha Subbarayan, Saurabh Dixit, Murtada A Taha, Chino D Cambridge, Vida A Dennis Center for NanoBiotechnology Research, Alabama State University, Montgomery, AL, USA Abstract: We recently demonstrated by in vitro experiments that PLGA (poly D, L-lactide-co-glycolide potentiates T helper 1 (Th1 immune responses induced by a peptide derived from the recombinant major outer membrane protein (rMOMP of Chlamydia trachomatis, and may be a promising vaccine delivery system. Herein we evaluated the immune-potentiating potential of PLGA by encapsulating the full-length rMOMP (PLGA-rMOMP, characterizing it in vitro, and investigating its immunogenicity in vivo. Our hypothesis was that PLGA-rMOMP triggers Th1 immune responses in mice, which are desirable prerequisites for a C. trachomatis candidate nanovaccine. Physical-structural characterizations of PLGA-rMOMP revealed its size (approximately 272 nm, zeta potential (−14.30 mV, apparent spherical smooth morphology, and continuous slow release pattern. PLGA potentiated the ability of encapsulated rMOMP to trigger production of cytokines and chemokines by mouse J774 macrophages. Flow cytometric analyses revealed that spleen cells from BALB/c mice immunized with PLGA-rMOMP had elevated numbers of CD4+ and CD8+ T cell subsets, and secreted more rMOMP-specific interferon-gamma (Th1 and interleukin (IL-12p40 (Th1/Th17 than IL-4 and IL-10 (Th2 cytokines. PLGA-rMOMP-immunized mice produced higher serum immunoglobulin (IgG and IgG2a (Th1 than IgG1 (Th2 rMOMP-specific antibodies. Notably, sera from PLGA-rMOMP-immunized mice had a 64-fold higher Th1 than Th2 antibody titer, whereas mice immunized with rMOMP in Freund's adjuvant had only a four-fold higher Th1 than Th2 antibody titer, suggesting primarily induction of a Th1 antibody response in PLGA-rMOMP-immunized mice. Our data underscore PLGA as an effective delivery system for a C

  1. High mobility group protein number17 cross-links primarily to histone H2A in the reconstituted HMG 17 - nucleosome core particle complex

    International Nuclear Information System (INIS)

    Cook, G.R.; Yau, P.; Yasuda, H.; Traut, R.R.; Bradbury, E.M.

    1986-01-01

    The neighbor relationship of lamb thymus High Mobility Group (HMG) protein 17 to native HeLa nucleosome core particle histones in the reconstituted complex has been studied. 125 I-labeled HMG 17 was cross-linking to core histones using the protein-protein cross-linking reagent 2-iminothiolane. Specific cross-linked products were separated on a two-dimensional Triton-acid-urea/SDS gel system, located by autoradiography, excised and quantified. Disulfide bonds in the cross links were then cleaved and the protein constituents were identified by SDS gel electrophoresis. HMG 17 cross-linked primarily to histone H2A while lower levels of cross-linking occurred between HMG 17 and the other histones. In contrast, cross-linking between two HMG 17 molecules bound on the same nucleosome was relatively rare. It is concluded that the same nucleosome was relatively rare. It is concluded that H2A comprises part of the HMG 17 binding site but that HMG 17 is sufficiently elongated and mobile to permit cross-linking to the other histones and to a second HMG 17 molecule. These results are in agreement with the current model for the structure of the nucleosome and the proposed binding sites for HMG 17

  2. Transport of thyroxine across the blood-brain barrier is directed primarily from brain to blood in the mouse

    International Nuclear Information System (INIS)

    Banks, W.A.; Kastin, A.J.; Michals, E.A.

    1985-01-01

    The role of the blood-brain barrier (BBB) in the transport of thyroxine was examined in mice. Radioiodinated (hot thyroxine (hT 4 ) administered icv had a half-time disappearance from the brain of 30 min. This increased to 60 min (p 4 ). The Km for this inhibition of hT 4 transport out of the brain by cT 4 was 9.66 pmole/brain. Unlabeled 3,3',5 triiodothyronine (cT 3 ) was unable to inhibit transport of hT 4 out of the brain, although both cT 3 (p 4 (p 3 ) to a small degree. Entry of hT 4 into the brain after peripheral administration was negligible and was not affected by either cT 4 nor cT 3 . By contrast, the entry of hT 3 into the brain after peripheral administration was inhibited by cT 3 (p 4 (p < 0.01). The levels of the unlabeled thyroid hormones administered centrally in these studies did not affect bulk flow, as assessed by labeled red blood cells (/sup 99m/Tc-RBC), or the carrier mediated transport of iodide out of the brain. Likewise, the vascular space of the brain and body, as assessed by /sup 99m/Tc-RBC, was unchanged by the levels of peripherally administered unlabeled thyroid hormones. Therefore, the results of these studies are not due to generalized effects of thyroid hormones on BBB transport. The results indicate that in the mouse the major carrier-mediated system for thyroxine in the BBB transports thyroxine out of the brain, while the major system for triiodothyronine transports hormone into the brain. 14 references, 3 figures, 2 tables

  3. Poly-thymidine oligonucleotides mediate activation of murine glial cells primarily through TLR7, not TLR8.

    Directory of Open Access Journals (Sweden)

    Min Du

    Full Text Available The functional role of murine TLR8 in the inflammatory response of the central nervous system (CNS remains unclear. Murine TLR8 does not appear to respond to human TLR7/8 agonists, due to a five amino acid deletion in the ectodomain. However, recent studies have suggested that murine TLR8 may be stimulated by alternate ligands, which include vaccinia virus DNA, phosphothioate oligodeoxynucleotides (ODNs or the combination of phosphothioate poly-thymidine oligonucleotides (pT-ODNs with TLR7/8 agonists. In the current study, we analyzed the ability of pT-ODNs to induce activation of murine glial cells in the presence or absence of TLR7/8 agonists. We found that TLR7/8 agonists induced the expression of glial cell activation markers and induced the production of multiple proinflammatory cytokines and chemokines in mixed glial cultures. In contrast, pT-ODNs alone induced only low level expression of two cytokines, CCL2 and CXCL10. The combination of pT-ODNs along with TLR7/8 agonists induced a synergistic response with substantially higher levels of proinflammatory cytokines and chemokines compared to CL075. This enhancement was not due to cellular uptake of the agonist, indicating that the pT-ODN enhancement of cytokine responses was due to effects on an intracellular process. Interestingly, this response was also not due to synergistic stimulation of both TLR7 and TLR8, as the loss of TLR7 abolished the activation of glial cells and cytokine production. Thus, pT-ODNs act in synergy with TLR7/8 agonists to induce strong TLR7-dependent cytokine production in glial cells, suggesting that the combination of pT-ODNs with TLR7 agonists may be a useful mechanism to induce pronounced glial activation in the CNS.

  4. Nanoparticles affect PCR primarily via surface interactions with PCR components: using amino-modified silica-coated magnetic nanoparticles as a main model

    Science.gov (United States)

    Nanomaterials have been widely reported to affect the polymerase chain reaction (PCR). However, many studies in which these effects were observed were not comprehensive, and many of the proposed mechanisms have been primarily speculative. In this work, we used amino-modified silica-coated magnetic n...

  5. Incidence of diseases primarily affecting the skin by age group: population-based epidemiologic study in Olmsted County, Minnesota, and comparison with age-specific incidence rates worldwide.

    Science.gov (United States)

    Wessman, Laurel L; Andersen, Louise K; Davis, Mark D P

    2018-01-29

    Understanding the effects of age on the epidemiology of diseases primarily affecting the skin is important to the practice of dermatology, both for proper allocation of resources and for optimal patient-centered care. To fully appreciate the effect that age may have on the population-based calculations of incidence of diseases primarily affecting the skin in Olmsted County, Minnesota, and worldwide, we performed a review of all relevant Rochester Epidemiology Project-published data and compared them to similar reports in the worldwide English literature. Using the Rochester Epidemiology Project, population-based epidemiologic studies have been performed to estimate the incidence of specific skin diseases over the past 50 years. In older persons (>65 years), nonmelanoma skin cancer, lentigo maligna, herpes zoster, delusional infestation, venous stasis syndrome, venous ulcer, and burning mouth syndrome were more commonly diagnosed. In those younger than 65 years, atypical nevi, psoriatic arthritis, pityriasis rosea, herpes progenitalis, genital warts, alopecia areata, hidradenitis suppurativa, infantile hemangioma, Behçet's disease, and sarcoidosis (isolated cutaneous, with sarcoidosis-specific cutaneous lesions and with erythema nodosum) had a higher incidence. Many of the incidence rates by age group of diseases primarily affecting the skin derived from the Rochester Epidemiology Project were similar to those reported elsewhere. © 2018 The International Society of Dermatology.

  6. Cost that is Directly Incurred as a Result of Operating the Train Service on the 1520 mm Rail with Primarily Freight Transportation

    OpenAIRE

    Hudenko, J; Ribakova, N; Počs, R

    2016-01-01

    Under the Directive 2012/34/EU (21 November 2012) "the charges for … [rail] infrastructure … shall be set at the cost that is directly incurred as a result of operating the train service". This charging rule is new for Baltic States’ railways, where due to the favorable geographic position a full cost application without detalization was possible. Although, a big number of relevant studies on the issue was made in EU, all of them covered only 1435mm railways with primarily passenger transport...

  7. A randomized trial of a DWI intervention program for first offenders: intervention outcomes and interactions with antisocial personality disorder among a primarily American-Indian sample.

    Science.gov (United States)

    Woodall, W Gill; Delaney, Harold D; Kunitz, Stephen J; Westerberg, Verner S; Zhao, Hongwei

    2007-06-01

    Randomized trial evidence on the effectiveness of incarceration and treatment of first-time driving while intoxicated (DWI) offenders who are primarily American Indian has yet to be reported in the literature on DWI prevention. Further, research has confirmed the association of antisocial personality disorder (ASPD) with problems with alcohol including DWI. A randomized clinical trial was conducted, in conjunction with 28 days of incarceration, of a treatment program incorporating motivational interviewing principles for first-time DWI offenders. The sample of 305 offenders including 52 diagnosed as ASPD by the Diagnostic Interview Schedule were assessed before assignment to conditions and at 6, 12, and 24 months after discharge. Self-reported frequency of drinking and driving as well as various measures of drinking over the preceding 90 days were available at all assessments for 244 participants. Further, DWI rearrest data for 274 participants were available for analysis. Participants randomized to receive the first offender incarceration and treatment program reported greater reductions in alcohol consumption from baseline levels when compared with participants who were only incarcerated. Antisocial personality disorder participants reported heavier and more frequent drinking but showed significantly greater declines in drinking from intake to posttreatment assessments. Further, the treatment resulted in larger effects relative to the control on ASPD than non-ASPD participants. Nonconfrontational treatment may significantly enhance outcomes for DWI offenders with ASPD when delivered in an incarcerated setting, and in the present study, such effects were found in a primarily American-Indian sample.

  8. Evaluating a County-Sponsored Social Marketing Campaign to Increase Mothers' Initiation of HPV Vaccine for their Pre-teen Daughters in a Primarily Rural Area.

    Science.gov (United States)

    Cates, Joan R; Shafer, Autumn; Diehl, Sandra J; Deal, Allison M

    2011-01-01

    Routine vaccination against human papillomavirus (HPV), the main cause of cervical cancer, is recommended for 11-12 year old girls, yet vaccine uptake is low. This study evaluates a social marketing campaign initiated by 13 North Carolina counties to raise awareness among parents and reduce barriers to accessing the vaccine in a primarily rural area. The 3-month campaign targeted mothers of girls ages 11-12 and healthcare practices serving pre-teen girls in four counties. Principles of social marketing were: product (recommended vaccine against HPV), price (cost, perception of safety and efficacy, and access), promotion (posters, brochures, website, news releases, doctor's recommendation), and place (doctors' offices, retail outlets). We analyzed (1) website traffic, hotline calls, and media placement; (2) cross-sectional surveys of mothers and providers; and (3) HPV immunization rates in intervention versus non-intervention counties. Of respondent mothers (n=225), 82% heard or saw campaign messages or materials. Of respondent providers (n=35), 94% used campaign brochures regularly or occasionally in conversations with parents. HPV vaccination rates within six months of campaign launch were 2% higher for 9-13 year old girls in two of the four intervention counties compared to 96 non-intervention counties. This evaluation supports campaign use in other primarily rural and underserved areas.

  9. Fragment-Specific Fixation Versus Volar Locking Plates in Primarily Nonreducible or Secondarily Redisplaced Distal Radius Fractures: A Randomized Controlled Study.

    Science.gov (United States)

    Landgren, Marcus; Abramo, Antonio; Geijer, Mats; Kopylov, Philippe; Tägil, Magnus

    2017-03-01

    To compare the patient-reported, clinical, and radiographic outcome of 2 methods of internal fixation in distal radius fractures. Fifty patients, mean age 56 years (range, 21-69 years) with primarily nonreducible or secondarily redisplaced distal radius fractures were randomized to open reduction internal fixation using volar locking plates (n = 25) or fragment-specific fixation (n = 25). The patients were assessed on grip strength, range of motion, patient-reported outcome (Quick Disabilities of the Arm, Shoulder, and Hand), pain (visual analog scale), health-related quality of life (Short Form-12 [SF-12]), and radiographic evaluation. Grip strength at 12 months was the primary outcome measure. At 12 months, no difference was found in grip strength, which was 90% of the uninjured side in the volar plate group and 87% in the fragment-specific fixation group. No differences were found in range of motion and the median Quick Disabilities of the Arm, Shoulder, and Hand score was 5 in both groups. The overall complication rate was significant, 21% in the volar locking plate group, compared with 52% in the fragment-specific group. In treatment of primarily nonreducible or secondarily redisplaced distal radius fractures, volar locking plates and fragment-specific fixation both achieve good and similar patient-reported outcomes, although more complications were recorded in the fragment-specific group. Therapeutic II. Copyright © 2017 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

  10. Evaluating a County-Sponsored Social Marketing Campaign to Increase Mothers’ Initiation of HPV Vaccine for their Pre-teen Daughters in a Primarily Rural Area

    Science.gov (United States)

    Cates, Joan R.; Shafer, Autumn; Diehl, Sandra J.; Deal, Allison M.

    2011-01-01

    Routine vaccination against human papillomavirus (HPV), the main cause of cervical cancer, is recommended for 11–12 year old girls, yet vaccine uptake is low. This study evaluates a social marketing campaign initiated by 13 North Carolina counties to raise awareness among parents and reduce barriers to accessing the vaccine in a primarily rural area. The 3-month campaign targeted mothers of girls ages 11–12 and healthcare practices serving pre-teen girls in four counties. Principles of social marketing were: product (recommended vaccine against HPV), price (cost, perception of safety and efficacy, and access), promotion (posters, brochures, website, news releases, doctor’s recommendation), and place (doctors’ offices, retail outlets). We analyzed (1) website traffic, hotline calls, and media placement; (2) cross-sectional surveys of mothers and providers; and (3) HPV immunization rates in intervention versus non-intervention counties. Of respondent mothers (n=225), 82% heard or saw campaign messages or materials. Of respondent providers (n=35), 94% used campaign brochures regularly or occasionally in conversations with parents. HPV vaccination rates within six months of campaign launch were 2% higher for 9–13 year old girls in two of the four intervention counties compared to 96 non-intervention counties. This evaluation supports campaign use in other primarily rural and underserved areas. PMID:21804767

  11. Interferon-gamma and tumor necrosis factor-alpha sensitize primarily resistant human endometrial stromal cells to Fas-mediated apoptosis

    DEFF Research Database (Denmark)

    Fluhr, Herbert; Krenzer, Stefanie; Stein, Gerburg M

    2007-01-01

    The subtle interaction between the implanting embryo and the maternal endometrium plays a pivotal role during the process of implantation. Human endometrial stromal cells (ESCs) express Fas and the implanting trophoblast cells secrete Fas ligand (FASLG, FasL), suggesting a possible role for Fas......-mediated signaling during early implantation. Here we show that ESCs are primarily resistant to Fas-mediated apoptosis independently of their state of hormonal differentiation. Pre-treatment of ESCs with interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha sensitizes them to become apoptotic upon stimulation...... of Fas by an agonistic anti-Fas antibody. Incubation of ESCs with the early embryonic signal human chorionic gonadotropin (hCG, CGB) does not influence their reaction to Fas stimulation. The sensitizing effect of IFN-gamma and TNF-alpha was accompanied by a significant upregulation of Fas and FLICE...

  12. Elevated plasma 8-iso-prostaglandin F2α levels in human smokers originate primarily from enzymatic instead of non-enzymatic lipid peroxidation.

    Science.gov (United States)

    van 't Erve, Thomas J; Lih, Fred B; Kadiiska, Maria B; Deterding, Leesa J; Mason, Ronald P

    2018-02-01

    It is widely accepted that free radicals in tobacco smoke lead to oxidative stress and generate the popular lipid peroxidation biomarker 8-iso-prostaglandin F 2α (8-iso-PGF 2α ). However, 8-iso-PGF 2α can simultaneously be produced in vivo by the prostaglandin-endoperoxide synthases (PGHS) induced by inflammation. This inflammation-dependent mechanism has never been considered as a source of elevated 8-iso-PGF 2α in tobacco smokers. The goal of this study is to quantify the distribution of chemical- and PGHS-dependent 8-iso-PGF 2α formation in the plasma of tobacco smokers and non-smokers. The influences of gender and hormonal contraceptive use were accounted for. The distribution was determined by measuring the 8-iso-PGF 2α /prostaglandin F 2α (PGF 2α ) ratio. When comparing smokers (n = 28) against non-smokers (n = 30), there was a statistically significant increase in the 8-iso-PGF 2α concentration. The source of this increased 8-iso-PGF 2α was primarily from PGHS. When stratifying for gender, the increase in 8-iso-PGF 2α in male smokers (n = 9) was primarily from PGHS. Interestingly, female smokers on hormonal contraceptives had increased 8-iso-PGF 2α in both pathways, whereas those not on hormonal contraceptives did not have increased 8-iso-PGF 2α . In conclusion, increased plasma 8-iso-PGF 2α in tobacco smokers has complex origins, with PGHS-dependent formation as the primary source. Accounting for both pathways provides a definitive measurement of both oxidative stress and inflammation. Published by Elsevier Inc.

  13. Prostaglandin (PG) E3 synthesis elicted by adrenergic stimuli in guinea-pig trachea (GPT) is mediated primarily by B2 adrenergic receptors

    International Nuclear Information System (INIS)

    Nadel, G.L.; Malik, K.U.; Lew, D.B.

    1990-01-01

    The purpose of this study was to examine arachidonic acid (AA) metabolism and to characterize the type of adrenergic receptor (AR) involved in the production of the major metabolite of this fatty acid. [ 14 C]AA was incubated with GPT-rings and the radiolabelled products were extracted and separated by TLC method. The medium was also assayed for radiolabelled immunoreactive PG's (iPG's) and leukotrienes (LT) B4 and C4 by RIA or Enzyme immunoassay (EIA) after exposure to various AR agonists. [ 14 C]AA was incorporated into GPT-rings and metabolized mainly into iPGE2 and smaller amounts into PGF2α. Trace amounts of PGD2 and 6-keto-PGF1α but not LTB4 or LTC4 were detected by RIA and/or EIA. Incubation of GPT rings for 15 minutes with isoproterenol and salbutamol resulted in a significant increase of PGE2 synthesis (optimum conc: 10 -7 , 10 -7 M respectively). In contrast, dobutamine, norepinephrine, phenylnephrine and xylazine (up to 10 -6 M) did not significantly increase PGE2 production. Isoproterenol-induced iPGE2 production was inhibited by a selective β2 antagonist, butoxamine (70%: 10 -7 M, 91%: 10 -6 M) and somewhat reduced by β1 antagonists practolol and metoprolol (30-64%:10 -6 M). These data suggest that isoproterenol induced iPGE2 synthesis is primarily mediated via activation of β2 adrenergic receptor

  14. Bacterial diversity shift determined by different diets in the gut of the spotted wing fly Drosophila suzukii is primarily reflected on acetic acid bacteria

    KAUST Repository

    Vacchini, Violetta

    2016-11-25

    The pivotal role of diet in shaping gut microbiota has been evaluated in different animal models, including insects. Drosophila flies harbour an inconstant microbiota among which acetic acid bacteria (AAB) are important components. Here, we investigated the bacterial and AAB components of the invasive pest Drosophila suzukii microbiota, by studying the same insect population separately grown on fruit-based or non-fruit artificial diet. AAB were highly prevalent in the gut under both diets (90 and 92% infection rates with fruits and artificial diet, respectively). Fluorescent in situ hybridization and recolonization experiments with green fluorescent protein (Gfp)-labelled strains showed AAB capability to massively colonize insect gut. High-throughput sequencing on 16S rRNA gene indicated that the bacterial microbiota of guts fed with the two diets clustered separately. By excluding AAB-related OTUs from the analysis, insect bacterial communities did not cluster separately according to the diet, suggesting that diet-based diversification of the community is primarily reflected on the AAB component of the community. Diet influenced also AAB alpha-diversity, with separate OTU distributions based on diets. High prevalence, localization and massive recolonization, together with AAB clustering behaviour in relation to diet, suggest an AAB role in the D. suzukii gut response to diet modification. This article is protected by copyright. All rights reserved.

  15. Salinity-induced inhibition of growth in the aquatic pteridophyte Azolla microphylla primarily involves inhibition of photosynthetic components and signaling molecules as revealed by proteome analysis.

    Science.gov (United States)

    Thagela, Preeti; Yadav, Ravindra Kumar; Mishra, Vagish; Dahuja, Anil; Ahmad, Altaf; Singh, Pawan Kumar; Tiwari, Budhi Sagar; Abraham, Gerard

    2017-01-01

    Salinity stress causes adverse physiological and biochemical changes in the growth and productivity of a plant. Azolla, a symbiotic pteridophyte and potent candidate for biofertilizer due to its nitrogen fixation ability, shows reduced growth and nitrogen fixation during saline stress. To better understand regulatory components involved in salinity-induced physiological changes, in the present study, Azolla microphylla plants were exposed to NaCl (6.74 and 8.61 ds/m) and growth, photochemical reactions of photosynthesis, ion accumulation, and changes in cellular proteome were studied. Maximum dry weight was accumulated in control and untreated plant while a substantial decrease in dry weight was observed in the plants exposed to salinity. Exposure of the organism to different concentrations of salt in hydroponic conditions resulted in differential level of Na + and K + ion accumulation. Comparative analysis of salinity-induced proteome changes in A. microphylla revealed 58 salt responsive proteins which were differentially expressed during the salt exposure. Moreover, 42 % spots among differentially expressed proteins were involved in different signaling events. The identified proteins are involved in photosynthesis, energy metabolism, amino acid biosynthesis, protein synthesis, and defense. Downregulation of these key metabolic proteins appears to inhibit the growth of A. microphylla in response to salinity. Altogether, the study revealed that in Azolla, increased salinity primarily affected signaling and photosynthesis that in turn leads to reduced biomass.

  16. Comparative Transcriptional Profiling Established the Awn as the Major Photosynthetic Organ of the Barley Spike While the Lemma and the Palea Primarily Protect the Seed

    Directory of Open Access Journals (Sweden)

    Tilahun Abebe

    2009-11-01

    Full Text Available The lemma, palea, and awn of a barley ( L. spike are photosynthetic organs that supply the developing seed with carbohydrates. The lemma and palea also enclose the seed and protect it from pathogens and insects. Despite the important roles they play, little information exists on gene expression in these organs that identifies their function. In this study, we compared gene expression among the lemma, palea, awn, and developing seed of barley during grain filling using the Barley1 Genome Array to identify highly expressed genes involved in the primary function of these organs. Hierarchical clustering and mixed model analysis revealed that the lemma and palea have closely related gene expression patterns. In addition, the lemma and palea overexpressed defense-related genes compared with the awn. The awn preferentially expressed genes for photosynthesis, the biosynthesis of chlorophyll and carotenoids, and reactive oxygen species scavenging. This suggests the lemma and palea are mainly protective organs whereas the awn is primarily a photosynthetic structure. The seed was enriched with genes for the biosynthesis of starch, storage proteins, enzyme inhibitors, and cell proliferation.

  17. Is Walking Capacity in Subjects with Multiple Sclerosis Primarily Related to Muscle Oxidative Capacity or Maximal Muscle Strength? A Pilot Study

    Directory of Open Access Journals (Sweden)

    Dominique Hansen

    2014-01-01

    Full Text Available Background and Purpose. Walking capacity is reduced in subjects with multiple sclerosis (MS. To develop effective exercise interventions to enhance walking capacity, it is important to determine the impact of factors, modifiable by exercise intervention (maximal muscle strength versus muscle oxidative capacity, on walking capacity. The purpose of this pilot study is to discriminate between the impact of maximal muscle strength versus muscle oxidative capacity on walking capacity in subjects with MS. Methods. From 24 patients with MS, muscle oxidative capacity was determined by calculation of exercise-onset oxygen uptake kinetics (mean response time during submaximal exercise bouts. Maximal muscle strength (isometric knee extension and flexion peak torque was assessed on dynamometer. All subjects completed a 6-minute walking test. Relationships between walking capacity (as a percentage of normal value and muscle strength (of knee flexors and extensors versus muscle oxidative capacity were assessed in multivariate regression analyses. Results. The expanded disability status score (EDSS showed a significant univariate correlation (r=-0.70, P<0.004 with walking capacity. In multivariate regression analyses, EDSS and mean response time, but not muscle strength, were independently related to walking capacity (P<0.05. Conclusions. Walking distance is, next to disability level and not taking neurologic symptoms/deficits into account, primarily related to muscle oxidative capacity in subjects with MS. Additional study is needed to further examine/verify these findings.

  18. Factors affecting the number and type of student research products for chemistry and physics students at primarily undergraduate institutions: A case study.

    Science.gov (United States)

    Mellis, Birgit; Soto, Patricia; Bruce, Chrystal D; Lacueva, Graciela; Wilson, Anne M; Jayasekare, Rasitha

    2018-01-01

    For undergraduate students, involvement in authentic research represents scholarship that is consistent with disciplinary quality standards and provides an integrative learning experience. In conjunction with performing research, the communication of the results via presentations or publications is a measure of the level of scientific engagement. The empirical study presented here uses generalized linear mixed models with hierarchical bootstrapping to examine the factors that impact the means of dissemination of undergraduate research results. Focusing on the research experiences in physics and chemistry of undergraduates at four Primarily Undergraduate Institutions (PUIs) from 2004-2013, statistical analysis indicates that the gender of the student does not impact the number and type of research products. However, in chemistry, the rank of the faculty advisor and the venue of the presentation do impact the number of research products by undergraduate student, whereas in physics, gender match between student and advisor has an effect on the number of undergraduate research products. This study provides a baseline for future studies of discipline-based bibliometrics and factors that affect the number of research products of undergraduate students.

  19. Factors affecting the number and type of student research products for chemistry and physics students at primarily undergraduate institutions: A case study

    Science.gov (United States)

    Soto, Patricia; Bruce, Chrystal D.; Lacueva, Graciela; Wilson, Anne M.; Jayasekare, Rasitha

    2018-01-01

    For undergraduate students, involvement in authentic research represents scholarship that is consistent with disciplinary quality standards and provides an integrative learning experience. In conjunction with performing research, the communication of the results via presentations or publications is a measure of the level of scientific engagement. The empirical study presented here uses generalized linear mixed models with hierarchical bootstrapping to examine the factors that impact the means of dissemination of undergraduate research results. Focusing on the research experiences in physics and chemistry of undergraduates at four Primarily Undergraduate Institutions (PUIs) from 2004–2013, statistical analysis indicates that the gender of the student does not impact the number and type of research products. However, in chemistry, the rank of the faculty advisor and the venue of the presentation do impact the number of research products by undergraduate student, whereas in physics, gender match between student and advisor has an effect on the number of undergraduate research products. This study provides a baseline for future studies of discipline-based bibliometrics and factors that affect the number of research products of undergraduate students. PMID:29698502

  20. Cis-Natural Antisense Transcripts Are Mainly Co-expressed with Their Sense Transcripts and Primarily Related to Energy Metabolic Pathways during Muscle Development.

    Science.gov (United States)

    Zhao, Yunxia; Hou, Ye; Zhao, Changzhi; Liu, Fei; Luan, Yu; Jing, Lu; Li, Xinyun; Zhu, Mengjin; Zhao, Shuhong

    2016-01-01

    Cis-natural antisense transcripts (cis-NATs) are a new class of RNAs identified in various species. However, the biological functions of cis-NATs are largely unknown. In this study, we investigated the transcriptional characteristics and functions of cis-NATs in the muscle tissue of lean Landrace and indigenous fatty Lantang pigs. In total, 3,306 cis-NATs of 2,469 annotated genes were identified in the muscle tissue of pigs. More than 1,300 cis-NATs correlated with their sense genes at the transcriptional level, and approximately 80% of them were co-expressed in the two breeds. Furthermore, over 1,200 differentially expressed cis-NATs were identified during muscle development. Function annotation showed that the cis-NATs participated in muscle development mainly by co-expressing with genes involved in energy metabolic pathways, including citrate cycle (TCA cycle), glycolysis or gluconeogenesis, mitochondrial activation and so on. Moreover, these cis-NATs and their sense genes abruptly increased at the transition from the late fetal stages to the early postnatal stages and then decreased along with muscle development. In conclusion, the cis-NATs in the muscle tissue of pigs were identified and determined to be mainly co-expressed with their sense genes. The co-expressed cis-NATs and their sense gene were primarily related to energy metabolic pathways during muscle development in pigs. Our results offered novel evidence on the roles of cis-NATs during the muscle development of pigs.

  1. (-)Deprenyl and (-)1-phenyl-2-propylaminopentane, [(-)PPAP], act primarily as potent stimulants of action potential-transmitter release coupling in the catecholaminergic neurons.

    Science.gov (United States)

    Knoll, J; Miklya, I; Knoll, B; Markó, R; Kelemen, K

    1996-01-01

    The activity of the catecholaminergic neurons in the rat brain is enhanced significantly 30 min after the subcutaneous injection of very small doses of (-)deprenyl (threshold doses: 0.01 mg/kg for noradrenergic neurons and 0.025 mg/kg for dopaminergic neurons). As a catecholaminergic activity enhancer (CAE) substance (-)deprenyl is about ten times more potent than its parent compound, (-)methamphetamine. While the (+)methamphetamine is 3-5 times more potent than (-)methamphetammine in releasing catecholamines, the (-)methamphetamine is the more potent CAE substance. The mechanism of the CAE effect of (-)deprenyl and (-)PPAP, a deprenyl-derived substance devoid of MAO inhibitory potency, was studied in rats by measuring: a) the release of catecholamines from striatum, substantia nigra, tuberculum olfactorium and locus coeruleus; b) the stimulation induced release of 3H-noradrenaline from the isolated brain stem; and c) the antagonistic effect against tetrabenazine-induced depression of learning in the shuttle box. The CAE effect was found to be unrelated: a) to the inhibition of MAO activity; b) to the inhibition of presynaptic catecholamine receptors; c) to the inhibition of the uptake of catecholamines; and d) to the release of catecholamines. It was concluded that (-)deprenyl and (-)PPAP act primarily as potent stimulants of action potential-transmitter release coupling in the catecholaminergic neurons of the brain. We show that both (-)deprenyl and (-)PPAP enhance the inward Ca2+ current in sino-auricular fibers of the frog heart. (-)PPAP was much more potent than either (+)PPAP or (-)deprenyl in this test.

  2. HIV/AIDS stigma among a sample of primarily African-American and Latino men who have sex with men social media users.

    Science.gov (United States)

    Garett, Renee; Smith, Justin; Chiu, Jason; Young, Sean D

    2016-01-01

    The recent increase in social media use allows these technologies to rapidly reach communities with higher HIV prevalence, such as African-American and Latino men who have sex with men (MSM). However, no studies have looked at HIV/AIDS stigma among social media users from African-American and Latino MSM communities, or the association between stigma and social media use among these groups. This study sought to assess the level of HIV/AIDS stigma among a sample of social media-using African-American and Latino MSM from Los Angeles. A total of 112 (primarily African-American and Latino, n = 98, 88%) MSM Facebook users completed a survey on demographics, online social network use, and HIV/AIDS stigma. A composite stigma score was created by taking the cumulative score from a 15-item stigma questionnaire. Cumulative logistic models were used to assess the association between HIV/AIDS stigma and online social network use. In general, participants reported a low level of HIV/AIDS stigma (mean = 22.2/75, SD = 5.74). HIV/AIDS stigma composite score was significantly associated with increased time spent on online social networks each day (Adjusted odds ratios (AOR): 1.07, 95% CI: 1.00, 1.15). Among this diverse sample of MSM online social network users, findings suggest that HIV/AIDS stigma is associated with usage of social media. We discuss the implications of this work for future HIV prevention.

  3. Prostaglandin (PG) E3 synthesis elicted by adrenergic stimuli in guinea-pig trachea (GPT) is mediated primarily by B2 adrenergic receptors

    Energy Technology Data Exchange (ETDEWEB)

    Nadel, G.L.; Malik, K.U.; Lew, D.B. (Univ. of Tennessee, Memphis (United States))

    1990-02-26

    The purpose of this study was to examine arachidonic acid (AA) metabolism and to characterize the type of adrenergic receptor (AR) involved in the production of the major metabolite of this fatty acid. ({sup 14}C)AA was incubated with GPT-rings and the radiolabelled products were extracted and separated by TLC method. The medium was also assayed for radiolabelled immunoreactive PG's (iPG's) and leukotrienes (LT) B4 and C4 by RIA or Enzyme immunoassay (EIA) after exposure to various AR agonists. ({sup 14}C)AA was incorporated into GPT-rings and metabolized mainly into iPGE2 and smaller amounts into PGF2{alpha}. Trace amounts of PGD2 and 6-keto-PGF1{alpha} but not LTB4 or LTC4 were detected by RIA and/or EIA. Incubation of GPT rings for 15 minutes with isoproterenol and salbutamol resulted in a significant increase of PGE2 synthesis (optimum conc: 10{sup {minus}7}, 10{sup {minus}7}M respectively). In contrast, dobutamine, norepinephrine, phenylnephrine and xylazine (up to 10{sup {minus}6}M) did not significantly increase PGE2 production. Isoproterenol-induced iPGE2 production was inhibited by a selective {beta}2 antagonist, butoxamine (70%: 10{sup {minus}7}M, 91%: 10{sup {minus}6}M) and somewhat reduced by {beta}1 antagonists practolol and metoprolol (30-64%:10{sup {minus}6}M). These data suggest that isoproterenol induced iPGE2 synthesis is primarily mediated via activation of {beta}2 adrenergic receptor.

  4. Sitagliptin reduces cardiac apoptosis, hypertrophy and fibrosis primarily by insulin-dependent mechanisms in experimental type-II diabetes. Potential roles of GLP-1 isoforms.

    Directory of Open Access Journals (Sweden)

    Belén Picatoste

    Full Text Available BACKGROUND: Myocardial fibrosis is a key process in diabetic cardiomyopathy. However, their underlying mechanisms have not been elucidated, leading to a lack of therapy. The glucagon-like peptide-1 (GLP-1 enhancer, sitagliptin, reduces hyperglycemia but may also trigger direct effects on the heart. METHODS: Goto-Kakizaki (GK rats developed type-II diabetes and received sitagliptin, an anti-hyperglycemic drug (metformin or vehicle (n=10, each. After cardiac structure and function assessment, plasma and left ventricles were isolated for biochemical studies. Cultured cardiomyocytes and fibroblasts were used for in vitro assays. RESULTS: Untreated GK rats exhibited hyperglycemia, hyperlipidemia, plasma GLP-1 decrease, and cardiac cell-death, hypertrophy, fibrosis and prolonged deceleration time. Moreover, cardiac pro-apoptotic/necrotic, hypertrophic and fibrotic factors were up-regulated. Importantly, both sitagliptin and metformin lessened all these parameters. In cultured cardiomyocytes and cardiac fibroblasts, high-concentration of palmitate or glucose induced cell-death, hypertrophy and fibrosis. Interestingly, GLP-1 and its insulinotropic-inactive metabolite, GLP-1(9-36, alleviated these responses. In addition, despite a specific GLP-1 receptor was only detected in cardiomyocytes, GLP-1 isoforms attenuated the pro-fibrotic expression in cardiomyocytes and fibroblasts. In addition, GLP-1 receptor signalling may be linked to PPARδ activation, and metformin may also exhibit anti-apoptotic/necrotic and anti-fibrotic direct effects in cardiac cells. CONCLUSIONS: Sitagliptin, via GLP-1 stabilization, promoted cardioprotection in type-II diabetic hearts primarily by limiting hyperglycemia e hyperlipidemia. However, GLP-1 and GLP-1(9-36 promoted survival and anti-hypertrophic/fibrotic effects on cultured cardiac cells, suggesting cell-autonomous cardioprotective actions.

  5. Building Footprints, Primarily residential, at risk buildings such as hospitals, nursing homes, etc for use in Emergency Management Hazard Mitigation planning., Published in 2010, 1:4800 (1in=400ft) scale, Carroll County Government.

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Building Footprints dataset current as of 2010. Primarily residential, at risk buildings such as hospitals, nursing homes, etc for use in Emergency Management Hazard...

  6. Conceptual System of Systems Enabling Maritime Dominance in the Littorals

    National Research Council Canada - National Science Library

    Holmes, Matt

    2004-01-01

    .... Focusing on only system-of systems (SoS) concepts, we consider a system of only manned platforms, a system of primarily unmanned platforms, and a balanced hybrid system of manned and unmanned platforms...

  7. Podocytes Degrade Endocytosed Albumin Primarily in Lysosomes

    Science.gov (United States)

    Carson, John M.; Okamura, Kayo; Wakashin, Hidefumi; McFann, Kim; Dobrinskikh, Evgenia; Kopp, Jeffrey B.; Blaine, Judith

    2014-01-01

    Albuminuria is a strong, independent predictor of chronic kidney disease progression. We hypothesize that podocyte processing of albumin via the lysosome may be an important determinant of podocyte injury and loss. A human urine derived podocyte-like epithelial cell (HUPEC) line was used for in vitro experiments. Albumin uptake was quantified by Western blot after loading HUPECs with fluorescein-labeled (FITC) albumin. Co-localization of albumin with lysosomes was determined by confocal microscopy. Albumin degradation was measured by quantifying FITC-albumin abundance in HUPEC lysates by Western blot. Degradation experiments were repeated using HUPECs treated with chloroquine, a lysosome inhibitor, or MG-132, a proteasome inhibitor. Lysosome activity was measured by fluorescence recovery after photo bleaching (FRAP). Cytokine production was measured by ELISA. Cell death was determined by trypan blue staining. In vivo, staining with lysosome-associated membrane protein-1 (LAMP-1) was performed on tissue from a Denys-Drash trangenic mouse model of nephrotic syndrome. HUPECs endocytosed albumin, which co-localized with lysosomes. Choloroquine, but not MG-132, inhibited albumin degradation, indicating that degradation occurs in lysosomes. Cathepsin B activity, measured by FRAP, significantly decreased in HUPECs exposed to albumin (12.5% of activity in controls) and chloroquine (12.8%), and declined further with exposure to albumin plus chloroquine (8.2%, palbumin and chloroquine alone, and these effects were potentiated by exposure to albumin plus chloroquine. Compared to wild-type mice, glomerular staining of LAMP-1 was significantly increased in Denys-Drash mice and appeared to be most prominent in podocytes. These data suggest lysosomes are involved in the processing of endocytosed albumin in podocytes, and lysosomal dysfunction may contribute to podocyte injury and glomerulosclerosis in albuminuric diseases. Modifiers of lysosomal activity may have therapeutic potential in slowing the progression of glomerulosclerosis by enhancing the ability of podocytes to process and degrade albumin. PMID:24924335

  8. Podocytes degrade endocytosed albumin primarily in lysosomes.

    Science.gov (United States)

    Carson, John M; Okamura, Kayo; Wakashin, Hidefumi; McFann, Kim; Dobrinskikh, Evgenia; Kopp, Jeffrey B; Blaine, Judith

    2014-01-01

    Albuminuria is a strong, independent predictor of chronic kidney disease progression. We hypothesize that podocyte processing of albumin via the lysosome may be an important determinant of podocyte injury and loss. A human urine derived podocyte-like epithelial cell (HUPEC) line was used for in vitro experiments. Albumin uptake was quantified by Western blot after loading HUPECs with fluorescein-labeled (FITC) albumin. Co-localization of albumin with lysosomes was determined by confocal microscopy. Albumin degradation was measured by quantifying FITC-albumin abundance in HUPEC lysates by Western blot. Degradation experiments were repeated using HUPECs treated with chloroquine, a lysosome inhibitor, or MG-132, a proteasome inhibitor. Lysosome activity was measured by fluorescence recovery after photo bleaching (FRAP). Cytokine production was measured by ELISA. Cell death was determined by trypan blue staining. In vivo, staining with lysosome-associated membrane protein-1 (LAMP-1) was performed on tissue from a Denys-Drash trangenic mouse model of nephrotic syndrome. HUPECs endocytosed albumin, which co-localized with lysosomes. Choloroquine, but not MG-132, inhibited albumin degradation, indicating that degradation occurs in lysosomes. Cathepsin B activity, measured by FRAP, significantly decreased in HUPECs exposed to albumin (12.5% of activity in controls) and chloroquine (12.8%), and declined further with exposure to albumin plus chloroquine (8.2%, plysosomes are involved in the processing of endocytosed albumin in podocytes, and lysosomal dysfunction may contribute to podocyte injury and glomerulosclerosis in albuminuric diseases. Modifiers of lysosomal activity may have therapeutic potential in slowing the progression of glomerulosclerosis by enhancing the ability of podocytes to process and degrade albumin.

  9. Clinical phase I/II trial to investigate neoadjuvant intensity-modulated short term radiation therapy (5 × 5 gy) and intraoperative radiation therapy (15 gy) in patients with primarily resectable pancreatic cancer - NEOPANC

    International Nuclear Information System (INIS)

    Roeder, Falk; Debus, Juergen; Huber, Peter E; Werner, Jens; Timke, Carmen; Saleh-Ebrahimi, Ladan; Schneider, Lutz; Hackert, Thilo; Hartwig, Werner; Kopp-Schneider, Annette; Hensley, Frank W; Buechler, Markus W

    2012-01-01

    The current standard treatment, at least in Europe, for patients with primarily resectable tumors, consists of surgery followed by adjuvant chemotherapy. But even in this prognostic favourable group, long term survival is disappointing because of high local and distant failure rates. Postoperative chemoradiation has shown improved local control and overalls survival compared to surgery alone but the value of additional radiation has been questioned in case of adjuvant chemotherapy. However, there remains a strong rationale for the addition of radiation therapy considering the high rates of microscopically incomplete resections after surgery. As postoperative administration of radiation therapy has some general disadvantages, neoadjuvant and intraoperative approaches theoretically offer benefits in terms of dose escalation, reduction of toxicity and patients comfort especially if hypofractionated regimens with highly conformal techniques like intensity-modulated radiation therapy are considered. The NEOPANC trial is a prospective, one armed, single center phase I/II study investigating a combination of neoadjuvant short course intensity-modulated radiation therapy (5 × 5 Gy) in combination with surgery and intraoperative radiation therapy (15 Gy), followed by adjuvant chemotherapy according to the german treatment guidelines, in patients with primarily resectable pancreatic cancer. The aim of accrual is 46 patients. The primary objectives of the NEOPANC trial are to evaluate the general feasibility of this approach and the local recurrence rate after one year. Secondary endpoints are progression-free survival, overall survival, acute and late toxicity, postoperative morbidity and mortality and quality of life. http://www.clinicaltrials.gov/ct2/show/NCT01372735

  10. The activation of p38 MAPK primarily contributes to UV-induced RhoB expression by recruiting the c-Jun and p300 to the distal CCAAT box of the RhoB promoter

    International Nuclear Information System (INIS)

    Ahn, Jiwon; Choi, Jeong-Hae; Won, Misun; Kang, Chang-Mo; Gyun, Mi-Rang; Park, Hee-Moon; Kim, Chun-Ho; Chung, Kyung-Sook

    2011-01-01

    Highlights: → Regulation of transcriptional activation of RhoB is still unclear. → We examine the effect of p38 MAPK inhibition, and c-Jun and RhoB depletion on UV-induced RhoB expression and apoptosis. → We identify the regions of RhoB promoter necessary to confer UV responsiveness using pRhoB-luciferase reporter assays. → c-Jun, ATF2 and p300 are dominantly associated with NF-Y on the distal CCAAT box. → The activation of p38 MAPK primarily contribute to UV-induced RhoB expression by recruiting the c-Jun and p300 proteins on distal CCAAT box of RhoB promoter. -- Abstract: The Ras-related small GTP-binding protein RhoB is rapidly induced in response to genotoxic stresses caused by ionizing radiation. It is known that UV-induced RhoB expression results from the binding of activating transcription factor 2 (ATF2) via NF-Y to the inverted CCAAT box (-23) of the RhoB promoter. Here, we show that the association of c-Jun with the distal CCAAT box (-72) is primarily involved in UV-induced RhoB expression and p38 MAPK regulated RhoB induction through the distal CCAAT box. UV-induced RhoB expression and apoptosis were markedly attenuated by pretreatment with the p38 MAPK inhibitor. siRNA knockdown of RhoB, ATF2 and c-Jun resulted in decreased RhoB expression and eventually restored the growth of UV-irradiated Jurkat cells. In the reporter assay using luciferase under the RhoB promoter, inhibition of RhoB promoter activity by the p38 inhibitor and knockdown of c-Jun using siRNA occurred through the distal CCAAT box. Immunoprecipitation and DNA affinity protein binding assays revealed the association of c-Jun and p300 via NF-YA and the dissociation of histone deacetylase 1 (HDAC1) via c-Jun recruitment to the CCAAT boxes of the RhoB promoter. These results suggest that the activation of p38 MAPK primarily contributes to UV-induced RhoB expression by recruiting the c-Jun and p300 proteins to the distal CCAAT box of the RhoB promoter in Jurkat cells.

  11. Signal system data mining

    Science.gov (United States)

    2000-09-01

    Intelligent transportation systems (ITS) include large numbers of traffic sensors that collect enormous quantities of data. The data provided by ITS is necessary for advanced forms of control, however basic forms of control, primarily time-of-day (TO...

  12. An empirical test of the information-motivation-behavioral skills model of ART adherence in a sample of HIV-positive persons primarily in out-of-HIV-care settings.

    Science.gov (United States)

    Horvath, Keith J; Smolenski, Derek; Amico, K Rivet

    2014-02-01

    The current body of evidence supporting the Information-Motivation-Behavioral Skills (IMB) model of antiretroviral therapy (ART) adherence rests exclusively on data collected from people living with HIV (PLWH) at point-of-HIV-care services. The aims of this study were to: (1) determine if the IMB model is a useful predictive model of ART adherence among PLWH who were primarily recruited in out-of-HIV-care settings; and (2) assess whether the theorized associations between IMB model constructs and adherence persist in the presence of depression and current drug use. PLWH (n = 312) responding to a one-time online survey completed the Life Windows IMB-ART-Adherence Questionnaire, and demographic, depression (CES-D 10), and drug use items. Path models were used to assess the fit of a saturated versus fully mediated IMB model of adherence and examined for moderating effects of depression and current drug use. Participants were on average 43 years of age, had been living with HIV for 9 or more years, and mostly male (84.0%), Caucasian (68.8%), and gay-identified (74.8%). The a priori measurement models for information and behavioral skills did not have acceptable fit to the data and were modified accordingly. Using the revised IMB scales, IMB constructs were associated with adherence as predicted by the theory in all but one model (i.e., the IMB model operated as predicted among nondrug users and those with and without depression). Among drug users, information exerted a direct effect on adherence but was not significantly associated with behavioral skills. Results of this study suggest that the fully or partially mediated IMB model is supported for use with samples of PLWH recruited primarily out-of-HIV-care service settings and is robust in the presence of depression and drug use.

  13. Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin

    Science.gov (United States)

    2012-01-01

    Background Influenza A virus non-structural protein 1 (NS1) is a virulence factor, which is targeted into the cell cytoplasm, nucleus and nucleolus. NS1 is a multi-functional protein that inhibits host cell pre-mRNA processing and counteracts host cell antiviral responses. Previously, we have shown that the NS1 protein of the H3N2 subtype influenza viruses possesses a C-terminal nuclear localization signal (NLS) that also functions as a nucleolar localization signal (NoLS) and targets the protein into the nucleolus. Results Here, we show that the NS1 protein of the human H3N2 virus subtype interacts in vitro primarily via its C-terminal NLS2/NoLS and to a minor extent via its N-terminal NLS1 with the nucleolar proteins, nucleolin and fibrillarin. Using chimeric green fluorescence protein (GFP)-NS1 fusion constructs, we show that the nucleolar retention of the NS1 protein is determined by its C-terminal NLS2/NoLS in vivo. Confocal laser microscopy analysis shows that the NS1 protein colocalizes with nucleolin in nucleoplasm and nucleolus and with B23 and fibrillarin in the nucleolus of influenza A/Udorn/72 virus-infected A549 cells. Since some viral proteins contain NoLSs, it is likely that viruses have evolved specific nucleolar functions. Conclusion NS1 protein of the human H3N2 virus interacts primarily via the C-terminal NLS2/NoLS and to a minor extent via the N-terminal NLS1 with the main nucleolar proteins, nucleolin, B23 and fibrillarin. PMID:22909121

  14. Inverse modeling and animation of growing single-stemmed trees at interactive rates

    Science.gov (United States)

    S. Rudnick; L. Linsen; E.G. McPherson

    2007-01-01

    For city planning purposes, animations of growing trees of several species can be used to deduce which species may best fit a particular environment. The models used for the animation must conform to real measured data. We present an approach for inverse modeling to fit global growth parameters. The model comprises local production rules, which are iteratively and...

  15. Marshall information retrieval and display system (MIRADS)

    Science.gov (United States)

    Groover, J. L.; Jones, S. C.; King, W. L.

    1974-01-01

    Program for data management system allows sophisticated inquiries while utilizing simplified language. Online system is composed of several programs. System is written primarily in COBOL with routines in ASSEMBLER and FORTRAN V.

  16. Systems

    International Nuclear Information System (INIS)

    Anon.

    1980-01-01

    Papers in this session describe the concept of mined geologic disposal system and methods for ensuring that the system, when developed, will meet all technical requirements. Also presented in the session are analyses of system parameters, such as cost and nuclear criticality potential, as well as a technical analysis of a requirement that the system permit retrieval of the waste for some period of time. The final paper discusses studies under way to investigate technical alternatives or complements to the mined geologic disposal system. Titles of the presented papers are: (1) Waste Isolation System; (2) Waste Isolation Economics; (3) BWIP Technical Baseline; (4) Criticality Considerations in Geologic Disposal of High-Level Waste; (5) Retrieving Nuclear Wastes from Repository; (6) NWTS Programs for the Evaluation of Technical Alternatives or Complements to Mined Geologic Repositories - Purpose and Objectives

  17. systems

    Directory of Open Access Journals (Sweden)

    Alexander Leonessa

    2000-01-01

    Full Text Available A nonlinear robust control-system design framework predicated on a hierarchical switching controller architecture parameterized over a set of moving nominal system equilibria is developed. Specifically, using equilibria-dependent Lyapunov functions, a hierarchical nonlinear robust control strategy is developed that robustly stabilizes a given nonlinear system over a prescribed range of system uncertainty by robustly stabilizing a collection of nonlinear controlled uncertain subsystems. The robust switching nonlinear controller architecture is designed based on a generalized (lower semicontinuous Lyapunov function obtained by minimizing a potential function over a given switching set induced by the parameterized nominal system equilibria. The proposed framework robustly stabilizes a compact positively invariant set of a given nonlinear uncertain dynamical system with structured parametric uncertainty. Finally, the efficacy of the proposed approach is demonstrated on a jet engine propulsion control problem with uncertain pressure-flow map data.

  18. Software Systems Stockroom

    Science.gov (United States)

    2009-11-01

    44  Figure 28: The Triples Report PHP Source .................................................................................. 46  iii...relational database management system (RDBMS). The RDBMS chosen for the S3 prototype is MySQL [9] due to its particular suitability for fronting database...backed websites. However, any RDBMS compliant with the Drupal content management system is suitable. S3 is developed primarily in the PHP

  19. Audit Management System

    CERN Document Server

    Alconada, Federico

    2015-01-01

    In the need of renewing their system, the Internal Audit department has given a proposal for building a new one. Taking into consideration the problems of their system they elaborated a requirement's list with the functionalities and features they were expecting from the new management system. This new system would be primarily for the use of the Internal Audit staff but it would also support the follow-up of internal audit recommendations by potentially all CERN staff members.

  20. SYSTEM

    Directory of Open Access Journals (Sweden)

    K. Swarnalatha

    2013-01-01

    Full Text Available Risk analysis of urban aquatic systems due to heavy metals turns significant due to their peculiar properties viz. persis tence, non-degradab ility, toxicity, and accumulation. Akkulam Veli (AV, an urba n tropical lake in south India is subjected to various environmental stresses due to multiple waste discharge, sand mining, developmental activities, tour ism related activitie s etc. Hence, a comprehensive approach is adopted for risk assessment using modified degree of contamination factor, toxicity units based on numerical sediment quality guidelines (SQGs, and potentialecological risk indices. The study revealed the presence of toxic metals such as Cr, C d, Pb and As and the lake is rated under ‘low ecological risk’ category.

  1. Job Satisfaction of School Psychologists in a Primarily Rural State.

    Science.gov (United States)

    Solly, David C.; Hohenshil, Thomas H.

    1986-01-01

    Job satisfaction of school psychologists practicing in West Virginia was studied using a modified version of the Minnesota Satisfaction Questionnaire. Job satisfaction increased as (1) salary increased, and (2) the supervisor's level of training reached the level of the practitioner and the area of training more closely approached that of a school…

  2. Is Self-Sacrificial Competitive Altruism Primarily a Male Activity?

    Directory of Open Access Journals (Sweden)

    Francis T. McAndrew

    2012-01-01

    Full Text Available This study explored the basis of self-sacrificial prosocial behavior in small groups. Seventy-eight undergraduates (39M, 39F filled out a thirty-item personality scale and then participated in a “group problem-solving study” in which the monetary success of a three-person group depended upon one of its members volunteering to endure pain (a cold stressor test and inconvenience (being soaked in a dunk tank. There were 13 groups consisting of two females and one male, and 13 groups consisting of two males and one female. Across groups, the behavior of the altruist was judged to be more costly, challenging, and important and he/she was liked better, rewarded with more money, and preferred as a future experimental partner. Groups containing two males showed more evidence of competition to become altruists than groups containing two females, and personality traits were more effective predictors of altruistic behavior in males than in females. We conclude that competition between males and “showing off” are key factors in triggering self-sacrificial altruistic behavior.

  3. Photoprotective substance occurs primarily in outer layers of fish skin.

    Science.gov (United States)

    Fabacher, D L; Little, E E

    1998-01-01

    Methanol extracts of dorsal skin layers, eyes, gills, and livers from ultraviolet-B (UVB) radiation-sensitive and UVB-tolerant species of freshwater fish were examined for a substance that appears to be photoprotective. Significantly larger amounts of this substance were found in extracts of outer dorsal skin layers from both UVB-sensitive and UVB-tolerant fish when compared with extracts of inner dorsal skin layers. This substance occurred in minor amounts or was not detected in eye, gill, and liver extracts. The apparent primary function of this substance in fish is to protect the cells in outer dorsal skin layers from harmful levels of UVB radiation.

  4. IGF-1 facilitates thrombopoiesis primarily through Akt activation.

    Science.gov (United States)

    Chen, Shilei; Hu, Mengjia; Shen, Mingqiang; Wang, Song; Wang, Cheng; Chen, Fang; Tang, Yong; Wang, Xinmiao; Zeng, Hao; Chen, Mo; Gao, Jining; Wang, Fengchao; Su, Yongping; Xu, Yang; Wang, Junping

    2018-05-25

    It is known that insulin-like growth factor-1 (IGF-1) also functions as a hematopoietic factor, while its direct effect on thrombopoiesis remains unclear. In this study, we show that IGF-1 is able to promote CD34+ cell differentiation toward megakaryocytes (MKs), as well as the facilitation of proplatelet formation (PPF) and platelet production from cultured MKs. The in vivo study demonstrates that IGF-1 administration accelerates platelet recovery in mice after 6.0Gy of irradiation and in mice that received bone marrow transplantation (BMT) following 10.0Gy of lethal irradiation. Subsequent investigations reveal that ERK1/2 and Akt activation mediate the effect of IGF-1 on thrombopoiesis. Notably, Akt activation induced by IGF-1 is more apparent than that of ERK1/2, compared with that of thrombopoietin (TPO) treatment. Moreover, the effect of IGF-1 on thrombopoiesis is independent of TPO signaling, because IGF-1 treatment can also lead to a significant increase of platelet counts in homozygous TPO receptor mutant mice. Further analysis indicates that the activation of Akt triggered by IGF-1 requires the assistance of steroid receptor coactivator-3 (SRC-3). Therefore, our data reveal a distinct role of IGF-1 in regulating thrombopoiesis, providing new insights into TPO-independent regulation of platelet generation. Copyright © 2018 American Society of Hematology.

  5. Broad Considerations Concerning Electrochemical Electrodes in Primarily Fluid Environments

    Directory of Open Access Journals (Sweden)

    Christopher G. Jesudason

    2009-05-01

    Full Text Available This review is variously a presentation, reflection, synthesis and report with reference to more recent developments of an article – in a journal which has ceased publication – entitled “Some Electrode Theorems with Experimental Corroboration, Inclusive of the Ag/AgCl System” Internet Journal of Chemistry, (http://www.ijc.com, Special Issues: Vol. 2 Article 24 (1999. The results from new lemmas relating charge densities and capacitance in a metallic electrode in equilibrium with an ionic solution are used to explain the data and observed effects due to Esin, Markov, Grahame, Lang and Kohn. Size effects that vary the measured e.m.f. of electrodes due to changes in the electronic chemical potential are demonstrated in experiment and theory implying the need for standardization of electrodes with respect to geometry and size. The widely used Stern modification of the Gouy-Chapman theory is shown to be mostly inapplicable for many of the problems where it is employed. Practical consequences of the current development include the possibility of determining the elusive single-ion activity coefficients of solution ions directly from the expression given by a simplified capacitance theorem, the potential of zero charge and the determination of single ion concentrations of active species in the electrode reactions from cell e.m.f. measurements.

  6. Kidneys and urinary system

    Energy Technology Data Exchange (ETDEWEB)

    Nair, G

    1993-12-31

    Nuclear medicine studies, through primarily concerned with the functional aspects of the organ, can also provide useful information about the anatomy. An understanding of the anatomy and physiology of the kidneys and urinary system greatly helps in the interpretation of data from radionuclide studies 9 figs, 3 tabs

  7. Mining Department computer systems

    Energy Technology Data Exchange (ETDEWEB)

    1979-09-01

    Describes the main computer systems currently available, or being developed by the Mining Department of the UK National Coal Board. They are primarily for the use of mining and specialist engineers, but some of them have wider applications, particularly in the research and development and management statistics fields.

  8. Kidneys and urinary system

    International Nuclear Information System (INIS)

    Nair, G.

    1992-01-01

    Nuclear medicine studies, through primarily concerned with the functional aspects of the organ, can also provide useful information about the anatomy. An understanding of the anatomy and physiology of the kidneys and urinary system greatly helps in the interpretation of data from radionuclide studies

  9. Nonstochastic Analysis of Manufacturing Systems Using Timed-Event Graphs

    DEFF Research Database (Denmark)

    Hulgaard, Henrik; Amon, Tod

    1996-01-01

    Using automated methods to analyze the temporal behavior ofmanufacturing systems has proven to be essential and quite beneficial.Popular methodologies include Queueing networks, Markov chains,simulation techniques, and discrete event systems (such as Petrinets). These methodologies are primarily...

  10. Mechanics of non-holonomic systems a new class of control systems

    CERN Document Server

    Soltakhanov, Sh Kh; Zegzhda, S A

    2009-01-01

    Mechanics of non-holonomic systems gives a deep insight into the theory and applications of Analytical Mechanics. The theory suggested is illustrated by the examples of a spacecraft motion. The book is primarily addressed to specialists in analytic mechanics.

  11. Modeling cellular systems

    CERN Document Server

    Matthäus, Franziska; Pahle, Jürgen

    2017-01-01

    This contributed volume comprises research articles and reviews on topics connected to the mathematical modeling of cellular systems. These contributions cover signaling pathways, stochastic effects, cell motility and mechanics, pattern formation processes, as well as multi-scale approaches. All authors attended the workshop on "Modeling Cellular Systems" which took place in Heidelberg in October 2014. The target audience primarily comprises researchers and experts in the field, but the book may also be beneficial for graduate students.

  12. Interacting effects of temperature integration and light intensity on growth and development of single-stemmed cut rose plants

    NARCIS (Netherlands)

    Dieleman, J.A.; Meinen, E.

    2007-01-01

    Energy conservation in horticulture can be achieved by allowing temperatures to fluctuate within predefined bandwidths instead of using rigid set points for heating and ventilation. In temperature integration, plants are supposed to compensate effects of temporarily deviations of the average

  13. Single Stem Cell Imaging and Analysis Reveals Telomere Length Differences in Diseased Human and Mouse Skeletal Muscles

    Directory of Open Access Journals (Sweden)

    Elisia D. Tichy

    2017-10-01

    Full Text Available Muscle stem cells (MuSCs contribute to muscle regeneration following injury. In many muscle disorders, the repeated cycles of damage and repair lead to stem cell dysfunction. While telomere attrition may contribute to aberrant stem cell functions, methods to accurately measure telomere length in stem cells from skeletal muscles have not been demonstrated. Here, we have optimized and validated such a method, named MuQ-FISH, for analyzing telomere length in MuSCs from either mice or humans. Our analysis showed no differences in telomere length between young and aged MuSCs from uninjured wild-type mice, but MuSCs isolated from young dystrophic mice exhibited significantly shortened telomeres. In corroboration, we demonstrated that telomere attrition is present in human dystrophic MuSCs, which underscores its importance in diseased regenerative failure. The robust technique described herein provides analysis at a single-cell resolution and may be utilized for other cell types, especially rare populations of cells.

  14. Cellular bases of radiation-induced residual insufficiency in the haematopoietic system

    International Nuclear Information System (INIS)

    Wangenheim, K.H. v.; Peterson, H.P.; Feinendegen, L.E.

    1984-01-01

    Following radiation exposure, man's survival and further well-being largely depends on the degree of damage to his heamatopietic system. Stem cells are particualarly sensitive to radiation. Over and beyond acute radiation damge, residual radiation damage is of significance since it reduces the performance of the haematopietic system and enhances the risk of leukaemia. Knowledge concerning cellular bases may be important for preventive and therapeutic measures. The measurement method presented is based on the fact that stem cells from transfused bone marrow will settle in the spleen of highly irradiated mice and be able to reconstruct the haematopietic system. Initally individual colonies can be observed which originate from a single stem cell and the proliferation of its descendants. Counting these colonies will give the number of stem cells. The reduction of the proliferation factor measured in the stem-cell quality test apparently is not due to a shift in the age structure of the stem cell compartment but to a damage which is located within a more or less substantial proportion of the stem cells themselves. This damage is the cause of stem cell descendant growth retarded on an average. It is probable that recovery observed after irradiation is brought about by less-damaged or undamaged stem cells replacing damaged ones. Initial results point to the fact that this replacement can be influenced by treatment after irradiation. (orig./MG) [de

  15. System control and display

    International Nuclear Information System (INIS)

    Jacobs, J.

    1977-01-01

    The system described was designed, developed, and installed on short time scales and primarily utilized of-the-shelf military and commercial hardware. The system was designed to provide security-in-depth and multiple security options with several stages of redundancy. Under normal operating conditions, the system is computer controlled with manual backup during abnormal conditions. Sensor alarm data are processed in conjunction with weather data to reduce nuisance alarms. A structured approach is used to order alarmed sectors for assessment. Alarm and video information is presented to security personnel in an interactive mode. Historical operational data are recorded for system evaluation

  16. Counselor Expert System | Debretsion | Zede Journal

    African Journals Online (AJOL)

    An expert system plays an important role on alleviating primarily shortage of experts in a specific area of interest. With the help of an expert system, personnel with little expertise can solve problems that require expert knowledge. In this paper all major aspects of an expert system development have been presented.

  17. Applying Sustainable Systems Development Approach to Educational Technology Systems

    Science.gov (United States)

    Huang, Albert

    2012-01-01

    Information technology (IT) is an essential part of modern education. The roles and contributions of technology to education have been thoroughly documented in academic and professional literature. Despite the benefits, the use of educational technology systems (ETS) also creates a significant impact on the environment, primarily due to energy…

  18. Evaluation of Ethiopian Tax Administration System: emphasis on ...

    African Journals Online (AJOL)

    , assessed the culture of voluntary compliance, looked at how taxpayers perceive service delivery by the revenue authority, and evaluated the fairness perception of the Ethiopian tax system. Data for the study were gathered primarily through ...

  19. Software for graphic display systems

    International Nuclear Information System (INIS)

    Karlov, A.A.

    1978-01-01

    In this paper some aspects of graphic display systems are discussed. The design of a display subroutine library is described, with an example, and graphic dialogue software is considered primarily from the point of view of the programmer who uses a high-level language. (Auth.)

  20. Unified Engineering Software System

    Science.gov (United States)

    Purves, L. R.; Gordon, S.; Peltzman, A.; Dube, M.

    1989-01-01

    Collection of computer programs performs diverse functions in prototype engineering. NEXUS, NASA Engineering Extendible Unified Software system, is research set of computer programs designed to support full sequence of activities encountered in NASA engineering projects. Sequence spans preliminary design, design analysis, detailed design, manufacturing, assembly, and testing. Primarily addresses process of prototype engineering, task of getting single or small number of copies of product to work. Written in FORTRAN 77 and PROLOG.

  1. Technology scan of future traveler information systems and applications in Georgia.

    Science.gov (United States)

    2013-10-01

    Statewide traveler information provided in Georgia through its NaviGAtor/5-1-1 system is : primarily based on Intelligent Transportation Systems (ITS) related to freeway traffic : management. The purpose of this study is to evaluate traveler informat...

  2. Notch Filters for Port-Hamiltonian Systems

    NARCIS (Netherlands)

    Dirksz, Danny; Scherpen, Jacquelien M.A.; van der Schaft, Abraham J.; Steinbuch, Maarten

    Many powerful tools exist for control design in the frequency domain, but are theoretically only justified for linear systems. On the other hand, nonlinear control deals with control design methodologies that are theoretically justified for a larger and more realistic class of systems, but primarily

  3. Parametric Optimization of Some Critical Operating System Functions--An Alternative Approach to the Study of Operating Systems Design

    Science.gov (United States)

    Sobh, Tarek M.; Tibrewal, Abhilasha

    2006-01-01

    Operating systems theory primarily concentrates on the optimal use of computing resources. This paper presents an alternative approach to teaching and studying operating systems design and concepts by way of parametrically optimizing critical operating system functions. Detailed examples of two critical operating systems functions using the…

  4. Advanced training systems

    Science.gov (United States)

    Savely, Robert T.; Loftin, R. Bowen

    1990-01-01

    Training is a major endeavor in all modern societies. Common training methods include training manuals, formal classes, procedural computer programs, simulations, and on-the-job training. NASA's training approach has focussed primarily on on-the-job training in a simulation environment for both crew and ground based personnel. NASA must explore new approaches to training for the 1990's and beyond. Specific autonomous training systems are described which are based on artificial intelligence technology for use by NASA astronauts, flight controllers, and ground based support personnel that show an alternative to current training systems. In addition to these specific systems, the evolution of a general architecture for autonomous intelligent training systems that integrates many of the features of traditional training programs with artificial intelligence techniques is presented. These Intelligent Computer Aided Training (ICAT) systems would provide much of the same experience that could be gained from the best on-the-job training.

  5. Argonne's atlas control system upgrade

    International Nuclear Information System (INIS)

    Munson, F.; Quock, D.; Chapin, B.; Figueroa, J.

    1999-01-01

    The ATLAS facility (Argonne Tandem-Linac Accelerator System) is located at the Argonne National Laboratory. The facility is a tool used in nuclear and atomic physics research, which focuses primarily on heavy-ion physics. The accelerator as well as its control system are evolutionary in nature, and consequently, continue to advance. In 1998 the most recent project to upgrade the ATLAS control system was completed. This paper briefly reviews the upgrade, and summarizes the configuration and features of the resulting control system

  6. Computerized hydraulic scanning system for quantitative non destructive examination

    International Nuclear Information System (INIS)

    Gundtoft, H.E.

    1982-01-01

    A hydraulic scanning system with five degrees of freedom is described. It is primarily designed as a universal system for fast and accurate ultrasonic inspection of materials for their internal variation in properties. The whole system is controlled by a minicomputer which also is used for evaluating and presenting of the results of the inspection. (author)

  7. Flexibility in 21st Century Power Systems

    Energy Technology Data Exchange (ETDEWEB)

    Cochran, J.; Miller, M.; Zinaman, O.; Milligan, M.; Arent, D.; Palmintier, B.; O' Malley, M.; Mueller, S.; Lannoye, E.; Tuohy, A.; Kujala, B.; Sommer, M.; Holttinen, H.; Kiviluoma, J.; Soonee, S. K.

    2014-05-01

    Flexibility of operation--the ability of a power system to respond to change in demand and supply--is a characteristic of all power systems. Flexibility is especially prized in twenty-first century power systems, with higher levels of grid-connected variable renewable energy (primarily, wind and solar). This paper summarizes the analytic frameworks that have emerged to measure this characteristic and distills key principles of flexibility for policy makers.

  8. Approximate Models for Closed-Loop Trajectory Tracking in Underactuated Systems

    Data.gov (United States)

    National Aeronautics and Space Administration — Control of robotic systems, as a field, spans both traditional closed-loop feedback techniques and modern machine learning strategies, which are primarily open-loop....

  9. A Basis for an Assembly Processor for COTS-Based Systems (APCS)

    National Research Council Canada - National Science Library

    Carney, David

    2003-01-01

    .... The framework is based on Barry Boehm's familiar spiral development process. However, it is primarily intended for projects that make significant use of commercial components and other preexisting software as elements of the system to be fielded...

  10. Integrated arterial and freeway operation control strategies for IVHS advanced traffic management systems : research report

    Science.gov (United States)

    1998-09-01

    The main focus of this study is congestion, primarily that occurring on freeway corridors in metropolitan areas. Lack of coordination in the operation of various components of the system is often a major source of inefficiency, : resulting in greater...

  11. Understanding Potential Changes to the Veterans Equitable Resource Allocation (VERA) System

    National Research Council Canada - National Science Library

    Wasserman, Jeffrey

    2004-01-01

    ... disabilities, low incomes, and special health care needs. In contrast to earlier VHA allocation systems, which were based largely on historical costs, VERA bases its allocation of finds primarily on the number of veterans served (work- load...

  12. Chemistry and Properties of Slags from Navy Solid Waste Destruction in the Plasma Arc System

    National Research Council Canada - National Science Library

    Talmy, Inna

    1999-01-01

    The U.S. Navy is currently developing a highly efficient shipboard system which employs a plasma torch to process Navy solid wastes primarily consisting of cardboard, paper, steel, aluminum, glass, and food waste...

  13. Complete system for portable gamma spectroscopy

    International Nuclear Information System (INIS)

    Fuess, D.A.

    1978-01-01

    The report described a system built around the Computing Gamma Spectrometer (PSA) LEA 74-008. The software primarily supports high-resolution gamma-ray spectroscopy using either a high-purity intrinsic germanium detector (HPGe) or a lithium-drifted germanium detector [Ge(Li)

  14. Automation Processes and Blockchain Systems

    OpenAIRE

    Hegadekatti, Kartik

    2017-01-01

    Blockchain Systems and Ubiquitous computing are changing the way we do business and lead our lives. One of the most important applications of Blockchain technology is in automation processes and Internet-of-Things (IoT). Machines have so far been limited in ability primarily because they have restricted capacity to exchange value. Any monetary exchange of value has to be supervised by humans or human-based centralised ledgers. Blockchain technology changes all that. It allows machines to have...

  15. The CUORE slow monitoring systems

    Science.gov (United States)

    Gladstone, L.; Biare, D.; Cappelli, L.; Cushman, J. S.; Del Corso, F.; Fujikawa, B. K.; Hickerson, K. P.; Moggi, N.; Pagliarone, C. E.; Schmidt, B.; Wagaarachchi, S. L.; Welliver, B.; Winslow, L. A.

    2017-09-01

    CUORE is a cryogenic experiment searching primarily for neutrinoless double decay in 130Te. It will begin data-taking operations in 2016. To monitor the cryostat and detector during commissioning and data taking, we have designed and developed Slow Monitoring systems. In addition to real-time systems using LabVIEW, we have an alarm, analysis, and archiving website that uses MongoDB, AngularJS, and Bootstrap software. These modern, state of the art software packages make the monitoring system transparent, easily maintainable, and accessible on many platforms including mobile devices.

  16. Technical note on drainage systems

    DEFF Research Database (Denmark)

    Bentzen, Thomas Ruby

    This technical note will present simple but widely used methods for the design of drainage systems. The note will primarily deal with surface water (rainwater) which on a satisfactorily way should be transport into the drainage system. Traditional two types of sewer systems exist: A combined system......, where rainwater and sewage is transported in the same pipe, and a separate system where the two types of water are transported in individual pipe. This note will only focus on the separate rain/stormwater system, however, if domestic sewage should be included in the dimensioning procedure, it......’s not major different than described below - just remember to include this contribution for combined systems where the surface water (rain) and sewage are carried in the same pipes in the system and change some of the parameters for failure allowance (this will be elaborated further later on). The technical...

  17. Rail transport systems approach

    CERN Document Server

    2017-01-01

    This book shows how the systems approach is employed by scientists in various countries to solve specific problems concerning railway transport. In particular, the book describes the experiences of scientists from Romania, Germany, the Czech Republic, the UK, Russia, Ukraine, Lithuania and Poland. For many of these countries there is a problem with the historical differences between the railways. In particular, there are railways with different rail gauges, with different signaling and communication systems, with different energy supplies and, finally, with different political systems, which are reflected in the different approaches to the management of railway economies. The book’s content is divided into two main parts, the first of which provides a systematic analysis of individual means of providing and maintaining rail transport. In turn, the second part addresses infrastructure and management development, with particular attention to security issues. Though primarily written for professionals involved...

  18. Improving the Utilisation of Management Information Systems in Secondary Schools

    Science.gov (United States)

    Bosker, R. J.; Branderhorst, E. M.; Visscher, A. J.

    2007-01-01

    Although most secondary schools do use management information systems (MISs), these systems tend not to be used to support higher order managerial activities but are currently primarily used for clerical purposes. This situation is unsatisfactory as MISs fully utilised could offer invaluable support to schools, which are increasingly being granted…

  19. Investigating Educational Systems, Leadership, and School Culture: A Holistic Approach

    Science.gov (United States)

    Pratt, Jill Elizabeth

    2014-01-01

    Most populous school districts operate using a bureaucratic hierarchical organizational structure developed primarily for industry, a system structure that has remained intact for a century despite evolving from a manufacturing to a knowledge-based economy. Although strong for efficiency, this system structure is resistant to change and promotes…

  20. Improving the utilisation of management information systems in secondary schools

    NARCIS (Netherlands)

    Bosker, R. J.; Branderhorst, E. M.; Visscher, A. J.

    2007-01-01

    Although most secondary schools do use management information systems (MISs), these systems tend not to be used to support higher order managerial activities but are currently primarily used for clerical purposes. This situation is unsatisfactory as MISs fully utilised could offer invaluable support

  1. Models and formal verification of multiprocessor system-on-chips

    DEFF Research Database (Denmark)

    Brekling, Aske Wiid; Hansen, Michael Reichhardt; Madsen, Jan

    2008-01-01

    present experimental results on rather small systems with high complexity, primarily due to differences between best-case and worst-case execution times. Considering worst-case execution times only, the system becomes deterministic and using a special version of {Uppaal}, where the no history is saved, we...

  2. 21 CFR 1020.40 - Cabinet x-ray systems.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Cabinet x-ray systems. 1020.40 Section 1020.40 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... are all x-ray systems designed primarily for the inspection of carry-on baggage at airline, railroad...

  3. 49 CFR 38.175 - High-speed rail cars, monorails and systems.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false High-speed rail cars, monorails and systems. 38....175 High-speed rail cars, monorails and systems. (a) All cars for high-speed rail systems, including... monorail systems operating primarily on dedicated rail (i.e., not used by freight trains) or guideway, in...

  4. 36 CFR 1192.175 - High-speed rail cars, monorails and systems.

    Science.gov (United States)

    2010-07-01

    ..., monorails and systems. 1192.175 Section 1192.175 Parks, Forests, and Public Property ARCHITECTURAL AND... TRANSPORTATION VEHICLES Other Vehicles and Systems § 1192.175 High-speed rail cars, monorails and systems. (a... steel-wheel-on-steel-rail technology, and monorail systems operating primarily on dedicated rail (i.e...

  5. Commercial dissemination approaches for solar home systems

    Energy Technology Data Exchange (ETDEWEB)

    Terrado, E.

    1997-12-01

    The author discusses the issue of providing solar home systems to primarily rural areas from the perspective of how to commercialize the process. He considers two different approaches, one an open market approach and the other an exclusive market approach. He describes examples of the exclusive market approach which are in process in Argentina and Brazil. Coming from a banking background, the business aspects are discussed in detail. He points out the strengths and weaknesses of both approaches toward developing such systems.

  6. PFN tool test and calibration system

    International Nuclear Information System (INIS)

    Stephenson, W.A.

    1981-12-01

    A system has been developed for the functional testing and neutron output calibration of the PFN (Prompt Fission Neutron) Uranium Logging Tool. The system was designed primarily for field work and consists of a special vehicle as well as test apparatus. Only the pertinent instrumentation is described. This document will serve as an Instruction and Test Equipment service manual for those involved with calibration of the neutron output of the PFN tool

  7. A proposed neutron spectrometer system for JET

    International Nuclear Information System (INIS)

    Elevant, T.; Hellbom, G.; Scheffel, J.; Malmskog, S.

    1979-12-01

    A neutron spectrometer system is proposed primarily for measurements of ion temperature and density and ion beam energy distribution in extended fusion plasmas like e.g. in JET. Three different spectrometers are involved: time of flight, proton recoil and 3 He. Energy resolutions of a few percent both for DD and DT neutrons are provided. Six order of magnitudes in flux ranges will be covered by the system when employing multi-target systems. A neutron collimator and shielding system will be desirable in order to obtain relevant information. Due to the entire differences in energy and fluxes for DD and DT plasmas a flexible collimator-shielding system is recommended

  8. Low noise PWC cathode readout system

    International Nuclear Information System (INIS)

    Cisneros, E.; Hutchinson, D.; McShurley, D.; Richter, R.; Shapiro, S.

    1980-10-01

    A system has been developed, primarily to detect the induced charge deposited on PWC cathodes, which is versatile, fast and has a good signal to noise ratio for signals of greater than or equal to 10 -14 Coulomb input. The amplifier system, which is completely separated from the detector by 95 Ω coaxial cables, is followed by a new charge integrating, version of the SHAM/BADC system developed at SLAC. This SHAM IV system is CAMAC based, allowing for computer calibration of the entire system from amplifier through ADC

  9. Fermilab D-0 Experimental Facility: Energy conservation report and mechanical systems design optimization and cost analysis study

    International Nuclear Information System (INIS)

    Krstulovich, S.F.

    1987-01-01

    This report is developed as part of the Fermilab D-0 Experimental Facility Project Title II Design Documentation Update. As such, it concentrates primarily on HVAC mechanical systems design optimization and cost analysis

  10. Metástasis cervical contralateral en el carcinoma epidermoide de la cavidad oral: Estudio clínico analítico retrospectivo en 315 pacientes primariamente tratados con cirugía Contralateral neck metastasis in squamous cell carcinoma of the oral cavity: An analytical retrospective clinical study of 315 patients primarily treated with surgery

    Directory of Open Access Journals (Sweden)

    R. González-García

    2008-06-01

    carcinoma epidermoide de lengua. El tiempo de supervivencia medio libre de enfermedad fue 147± 6 meses. Veintinueve (9,1% pacientes desarrollaron recurrencia cervical ipsilateral, mientras que 18 (5,69% mostraron recurrencia cervical contralateral. Para los pacientes con carcinoma epidermoide de lengua, y considerando los porcentajes en relación a los 203 pacientes con esta entidad, estas cifras fueron de 20 (9,8% y 9 (4,4%, respectivamente. El tiempo medio de aparición de las metástasis cervicales desde la cirugía fue de 12,52 meses (rango: 3-49, algo menor para el subgrupo de pacientes con carcinoma epidermoide de lengua (11,4 meses, rango: 3-27. Dieciocho de los 29 pacientes con recurrencia cervical ipsilateral murieron finalmente de la enfermedad. Siete de 18 pacientes con metástasis contralateral murieron igualmente de la enfermedad. En el subgrupo de pacientes con carcinoma epidermoide de lengua, estas cifras fueron: catorce de 20 pacientes con metástasis cervical ipsilateral y ocho de 9 pacientes con metástasis cervical contralateral. Varios factores clínicopatológicos mostraron asociación estadísticamente significativa (pObjectives. There are numerous studies in the literature on the prognostic factors involved in the appearance of ipsilateral neck metastasis in squamous cell carcinoma of the oral cavity. However, there are no extensive clinical studies on the association of clinicopathological factors and the appearance of contralateral neck metastasis after the surgical resection of the primary tumor. The object of this study is to analyze the factors implied in the appearance of contralateral neck metastasis in patients with squamous cell carcinoma of the oral cavity treated primarily with surgery. Patients and methods. A series of 315 consecutive patients with squamous cell carcinoma of the oral cavity, who had not been treated previously, were analyzed. A complementary study of a subgroup of 203 patients with squamous cell carcinoma of the lateral

  11. Delays and networked control systems

    CERN Document Server

    Hetel, Laurentiu; Daafouz, Jamal; Johansson, Karl

    2016-01-01

    This edited monograph includes state-of-the-art contributions on continuous time dynamical networks with delays. The book is divided into four parts. The first part presents tools and methods for the analysis of time-delay systems with a particular attention on control problems of large scale or infinite-dimensional systems with delays. The second part of the book is dedicated to the use of time-delay models for the analysis and design of Networked Control Systems. The third part of the book focuses on the analysis and design of systems with asynchronous sampling intervals which occur in Networked Control Systems. The last part of the book exposes several contributions dealing with the design of cooperative control and observation laws for networked control systems. The target audience primarily comprises researchers and experts in the field of control theory, but the book may also be beneficial for graduate students. .

  12. 37th National Systems Conference

    CERN Document Server

    Yadav, Sandeep; Adhikari, Bibhas; Seshadri, Harinipriya; Fulwani, Deepak

    2015-01-01

    The book is a collection of peer-reviewed scientific papers submitted by active researchers in the 37th National System Conference (NSC 2013). NSC is an annual event of the Systems Society of India (SSI), primarily oriented to strengthen the systems movement and its applications for the welfare of humanity. A galaxy of academicians, professionals, scientists, statesman and researchers from different parts of the country and abroad are invited to attend the conference. The book presents research articles in the areas of system’s modelling, complex network modelling, cyber security, sustainable systems design, health care systems, socio-economic systems, and clean and green technologies. The book can be used as a tool for further research.

  13. Interconnecting heterogeneous database management systems

    Science.gov (United States)

    Gligor, V. D.; Luckenbaugh, G. L.

    1984-01-01

    It is pointed out that there is still a great need for the development of improved communication between remote, heterogeneous database management systems (DBMS). Problems regarding the effective communication between distributed DBMSs are primarily related to significant differences between local data managers, local data models and representations, and local transaction managers. A system of interconnected DBMSs which exhibit such differences is called a network of distributed, heterogeneous DBMSs. In order to achieve effective interconnection of remote, heterogeneous DBMSs, the users must have uniform, integrated access to the different DBMs. The present investigation is mainly concerned with an analysis of the existing approaches to interconnecting heterogeneous DBMSs, taking into account four experimental DBMS projects.

  14. Are Integrated Portfolio Systems the Answer? An Evaluation of a Web-Based Portfolio System to Improve Preservice Teachers' Reflective Thinking Skills

    Science.gov (United States)

    Oner, Diler; Adadan, Emine

    2016-01-01

    This study investigated the effectiveness of an integrated web-based portfolio system, namely the BOUNCE System, which primarily focuses on improving preservice teachers' reflective thinking skills. BOUNCE©, the software component of the system, was designed and developed to support a teaching practice model including a cycle of activities to be…

  15. Introducing remarks upon the analysis of computer systems performance

    International Nuclear Information System (INIS)

    Baum, D.

    1980-05-01

    Some of the basis ideas of analytical techniques to study the behaviour of computer systems are presented. Single systems as well as networks of computers are viewed as stochastic dynamical systems which may be modelled by queueing networks. Therefore this report primarily serves as an introduction to probabilistic methods for qualitative analysis of systems. It is supplemented by an application example of Chandy's collapsing method. (orig.) [de

  16. Surface Moisture Measurement System Operation and Maintenance Manual

    International Nuclear Information System (INIS)

    Ritter, G.A.; Pearce, K.L.; Stokes, T.L.

    1995-12-01

    This operations and maintenance manual addresses deployment, equipment and field hazards, operating instructions, calibration verification, removal, maintenance, and other pertinent information necessary to safely operate and store the Surface Moisture Measurement System (SMMS) and Liquid Observation Well Moisture Measurement System (LOWMMS). These systems were developed primarily in support of Tank Waste Remediation System (TWRS) Safety Programs for moisture measurement in organic and ferrocyanide watch list tanks

  17. Mobile nuclear power systems

    International Nuclear Information System (INIS)

    Andersson, B.

    1988-11-01

    This report is meant to present a general survey of the mobile nuclear power systems and not a detailed review of their technical accomplishments. It is based in published material mainly up to 1987. Mobile nuclear power systems are of two fundamentally different kinds: nuclear reactors and isotopic generators. In the reactors the energy comes from nuclear fission and in the isotopic generators from the radioactive decay of suitable isotopes. The reactors are primarily used as power sourves on board nuclear submarines and other warships but have also been used in the space and in remote places. Their thermal power has ranged from 30 kWth (in a satellite) to 175 MWth (on board an aircraft carrier). Isotopic generators are suitable only for small power demands and have been used on board satellites and spaceprobes, automatic weatherstations, lighthouses and marine installations for navigation and observation. (author)

  18. Antares automatic beam alignment system

    International Nuclear Information System (INIS)

    Appert, Q.; Swann, T.; Sweatt, W.; Saxman, A.

    1980-01-01

    Antares is a 24-beam-line CO 2 laser system for controlled fusion research, under construction at Los Alamos Scientific Laboratory (LASL). Rapid automatic alignment of this system is required prior to each experiment shot. The alignment requirements, operational constraints, and a developed prototype system are discussed. A visible-wavelength alignment technique is employed that uses a telescope/TV system to view point light sources appropriately located down the beamline. Auto-alignment is accomplished by means of a video centroid tracker, which determines the off-axis error of the point sources. The error is nulled by computer-driven, movable mirrors in a closed-loop system. The light sources are fiber-optic terminations located at key points in the optics path, primarily at the center of large copper mirrors, and remotely illuminated to reduce heating effects

  19. The macrophage-histiocytic system

    Energy Technology Data Exchange (ETDEWEB)

    Cross, A

    1971-04-01

    The macrophage-histiocytic system is primarily concerned with the phagocytosis and degradation either of foreign material that enters the organism or of senile and damaged cells belonging to the organism itself. The system includes various kinds of cells with the common ability to process and eventually degrade and digest the ingested material. Two morphological characteristics of these cells are linked to their phagocytic functions: intra-cytoplasmic vacuoles and lysosomes. Although endothelial and fibroblastic cells can ingest particles, it seems that most cells of the macrophage-histiocytic system belong to the monocyte series. The stem cell of the system is still a matter for discussion and the mature cells have attracted a large and confusing array of names. Most of the experimental work with irradiation has involved macrophages of the peritoneal cavity and lymph nodes. It is likely that the other cells of the macrophage-histiocytic system are affected in the same way by irradiation, but this is not certain.

  20. Development of atmospheric polarization LIDAR System

    International Nuclear Information System (INIS)

    Ghalumyan, A.S.; Ghazaryan, V.R.

    2016-01-01

    LIDAR (Light Detection And Ranging) system sensitive to the polarization of the backscattered signal is being developed in Yerevan Physics Institute. The system is designed primarily for remote sensing of the atmospheric electric fields. At present, the system is being tuned for measuring vertical atmospheric backscatter profiles of aerosols and hydrometeors, analyze the depolarization ratio of elastic backscattered laser beams and investigate the influence of external factors on the beam polarization. In this paper, we describe the complete LIDAR system – the laser transmitter, receiving telescope and the polarization separator. The data acquisition and processing techniques are also described. (author)

  1. Consumer Health Information Provision in Rural Public Libraries: A Comparison of Two Library Systems

    Science.gov (United States)

    Flaherty, Mary Grace

    2013-01-01

    To better understand health information provision in the public library setting, two cooperative library systems that serve primarily rural populations in upstate New York were studied. The central library in one of those systems established a consumer health information center (CHIC) in 1999. In the other system, the central library does not have…

  2. 36th national systems conference on recent advancements in system modelling applications

    CERN Document Server

    Krishnan, J

    2013-01-01

    The book is a collection of peer-reviewed scientific papers submitted by active researchers in the 36th National System Conference (NSC 2012). NSC is an annual event of the Systems Society of India (SSI), primarily oriented to strengthen the systems movement and its applications for the welfare of humanity. A galaxy of academicians, professionals, scientists, statesman and researchers from different parts of the country and abroad are invited to attend the Conference. The book presents various research articles in the area of system modelling in all disciplines of engineering sciences as well as socio-economic systems. The book can be used as a tool for further research.

  3. Solar System Dynamics

    Science.gov (United States)

    Wisdom, Jack

    2002-01-01

    In these 18 years, the research has touched every major dynamical problem in the solar system, including: the effect of chaotic zones on the distribution of asteroids, the delivery of meteorites along chaotic pathways, the chaotic motion of Pluto, the chaotic motion of the outer planets and that of the whole solar system, the delivery of short period comets from the Kuiper belt, the tidal evolution of the Uranian arid Galilean satellites, the chaotic tumbling of Hyperion and other irregular satellites, the large chaotic variations of the obliquity of Mars, the evolution of the Earth-Moon system, and the resonant core- mantle dynamics of Earth and Venus. It has introduced new analytical and numerical tools that are in widespread use. Today, nearly every long-term integration of our solar system, its subsystems, and other solar systems uses algorithms that was invented. This research has all been primarily Supported by this sequence of PGG NASA grants. During this period published major investigations of tidal evolution of the Earth-Moon system and of the passage of the Earth and Venus through non-linear core-mantle resonances were completed. It has published a major innovation in symplectic algorithms: the symplectic corrector. A paper was completed on non-perturbative hydrostatic equilibrium.

  4. The CEBAF control system

    International Nuclear Information System (INIS)

    Watson, W.A. III.

    1995-01-01

    CEBAF has recently upgraded its accelerator control system to use EPICS, a control system toolkit being developed by a collaboration among laboratories in the US and Europe. The migration to EPICS has taken place during a year of intense commissioning activity, with new and old control systems operating concurrently. Existing CAMAC hardware was preserved by adding a CAMAC serial highway link to VME; newer hardware developments are now primarily in VME. Software is distributed among three tiers of computers: first, workstations and X terminals for operator interfaces and high level applications; second, VME single board computers for distributed access to hardware and for local control processing; third, embedded processors where needed for faster closed loop operation. This system has demonstrated the ability to scale EPICS to controlling thousands of devices, including hundreds of embedded processors, with control distributed among dozens of VME processors executing more than 125,000 EPICS database records. To deal with the large size of the control system, CEBAF has integrated an object oriented database, providing data management capabilities for both low level I/O and high level machine modeling. A new callable interface which is control system independent permits access to live EPICS data, data in other Unix processes, and data contained in the object oriented database

  5. Time delay systems theory, numerics, applications, and experiments

    CERN Document Server

    Ersal, Tulga; Orosz, Gábor

    2017-01-01

    This volume collects contributions related to selected presentations from the 12th IFAC Workshop on Time Delay Systems, Ann Arbor, June 28-30, 2015. The included papers present novel techniques and new results of delayed dynamical systems. The topical spectrum covers control theory, numerical analysis, engineering and biological applications as well as experiments and case studies. The target audience primarily comprises research experts in the field of time delay systems, but the book may also be beneficial for graduate students alike. .

  6. The GEANT4 Visualization System

    International Nuclear Information System (INIS)

    Allison, J

    2007-01-01

    The Geant4 Visualization System is a multi-driver graphics system designed to serve the Geant4 Simulation Toolkit. It is aimed at the visualization of Geant4 data, primarily detector descriptions and simulated particle trajectories and hits. It can handle a variety of graphical technologies simultaneously and interchangeably, allowing the user to choose the visual representation most appropriate to requirements. It conforms to the low-level Geant4 abstract graphical user interfaces and introduces new abstract classes from which the various drivers are derived and that can be straightforwardly extended, for example, by the addition of a new driver. It makes use of an extendable class library of models and filters for data representation and selection. The Geant4 Visualization System supports a rich set of interactive commands based on the Geant4 command system. It is included in the Geant4 code distribution and maintained and documented like other components of Geant4

  7. The National Shipbuilding Research Program. 1997 Ship Production Symposium. Implementation of Integrated CAD/CAM Systems in Small and Medium Sized Shipyards: A Case Study

    National Research Council Canada - National Science Library

    Mercier, Larry; Byington, Tracy; Senkwic, Walt; Barry, Christopher

    1997-01-01

    .... Implementing CAD/CAM is primarily a management, rather than technical, challenge. Performance-Based Management Techniques were used to develop the new system as an integrated whole, controlled and documented under ISO 9001...

  8. Aurora laser optical system

    International Nuclear Information System (INIS)

    Hanlon, J.A.; McLeod, J.

    1987-01-01

    Aurora is the Los Alamos short-pulse high-power krypton fluoride laser system. It is primarily an end-to-end technology demonstration prototype for large-scale UV laser systems of interest for short-wavelength inertial confinement fusion (ICF) investigations. The system is designed to employ optical angular multiplexing and aerial amplification by electron-beam-driven KrF laser amplifiers to deliver to ICF targets a stack of pulses with a duration of 5 ns containing several kilojoules at a wavelength of 248 nm. A program of high-energy density plasma physics investigations is now planned, and a sophisticated target chamber was constructed. The authors describe the design of the optical system for Aurora and report its status. This optical system was designed and is being constructed in two phases. The first phase carries only through the amplifier train and does not include a target chamber or any demultiplexing. Installation should be complete, and some performance results should be available. The second phase provides demultiplexing and carries the laser light to target. The complete design is reported

  9. Biocomplexity in coupled natural–human systems: a multidimensional framework

    Science.gov (United States)

    S.T.A. Pickett; M.L. Cadenasso; J.M. Grove

    2005-01-01

    As defined by Ascher, biocomplexity results from a "multiplicity of interconnected relationships and levels. "However, no integrative framework yet exists to facilitate the application of this concept to coupled human-natural systems. Indeed, the term "biocomplexity" is still used primarily as a creative and provocative metaphor. To help advance its...

  10. Basic Graphical Data Management System (BAGDAMS version 1.0)

    International Nuclear Information System (INIS)

    Weindorf, J.W.

    1979-06-01

    BAGDAMS (BAsic Graphical DAta Management System) is a set of FORTRAN callable subroutines which provides mass storage data structuring and manipulation capabilities. Although primarily designed to facilitate the handling of graphical data files (files containing information to be displayed upon graphical hardware devices), BAGDAMS can also be used in many other applications requiring complex mass storage resident data structures. (author)

  11. Resilience of Athabascan subsistence systems to interior Alaska's changing climate

    Science.gov (United States)

    Gary P. Kofinas; F. Stuart Chapin; Shauna BurnSilver; Jennifer I. Schmidt; Nancy L. Fresco; Knut Kielland; Stephanie Martin; Anna Springsteen; T. Scott Rupp

    2010-01-01

    Subsistence harvesting and wild food production by Athabascan peoples is part of an integrated social-ecological system of interior Alaska. We describe effects of recent trends and future climate change projections on the boreal ecosystem of interior Alaska and relate changes in ecosystem services to Athabascan subsistence. We focus primarily on moose, a keystone...

  12. Critical Appraisal of the System of Education and Prospects of ...

    African Journals Online (AJOL)

    The main purpose of this article is to review the South African system of education and assess the country's prospects of meeting current and future manpower and developmental needs. This inquiry is based primarily on an assessment of the current status quo in education in South Africa in order to gain a better ...

  13. The Mirror Neuron System: Grasping Others' Actions from Birth?

    Science.gov (United States)

    Lepage, Jean-Francois; Theoret, Hugo

    2007-01-01

    In the adult human brain, the presence of a system matching the observation and the execution of actions is well established. This mechanism is thought to rely primarily on the contribution of so-called "mirror neurons", cells that are active when a specific gesture is executed as well as when it is seen or heard. Despite the wealth of evidence…

  14. Project ME: A Report on the Learning Wall System.

    Science.gov (United States)

    Heilig, Morton L.

    The learning wall system, which consists primarily of a special wall used instead of a screen for a variety of projection purposes, is described, shown diagrammatically, and pictured. Designed to provide visual perceptual motor training on a level that would fall between gross and fine motor performance for perceptually handicapped children, the…

  15. Wind power variability and power system reserves in South Africa

    DEFF Research Database (Denmark)

    Sørensen, Poul Ejnar; Litong-Palima, Marisciel; Hahmann, Andrea N.

    2017-01-01

    Variable renewable generation, primarily from wind and solar, introduces new uncertainties in the operation of power systems. This paper describes and applies a method to quantify how wind power development will affect the use of short-term automatic reserves in the future South African power sys...

  16. Designing Bioretention Systems to Improve Nitrogen Removal - poster

    Science.gov (United States)

    Rain gardens, also referred to as bioretention systems, are designed primarily to infiltrate stormwater flow and reduce surface runoff and peak flows to receiving streams. Additionally, they are known to remove stressors from urban stormwater runoff, including oil and grease, pho...

  17. Cotton Transportation and Logistics: A Dynamic System

    OpenAIRE

    Robinson, John R.; Park, John L.; Fuller, Stephen

    2007-01-01

    The paper reviews the evolution of U.S. cotton transportation and logistics patterns over the last three decades. There have been many forces of change over this time period, with the largest change being a shift from primarily domestic market destinations to the international market. We describe the pre-1999 system and flow patterns when domestic consumption of U.S. cotton was dominant. We contrast this with current flow patterns as measured by available secondary export data and a sample of...

  18. Collective motion in behaviorally heterogeneous systems

    OpenAIRE

    Copenhagen, Katherine

    2017-01-01

    Collective motion is a widespread phenomenon in nature where individuals actively propel themselves, gather together and move as a group. Some examples of collective motion are bird flocks, fish schools, bacteria swarms, cell clusters, and crowds of people. Many models seek to understand the effects of activity in collective systems including things such as environmental disorder, density, and interaction details primarily at infinite size limits and with uniform populations. In this disserta...

  19. Simulation approach towards energy flexible manufacturing systems

    CERN Document Server

    Beier, Jan

    2017-01-01

    This authored monograph provides in-depth analysis and methods for aligning electricity demand of manufacturing systems to VRE supply. The book broaches both long-term system changes and real-time manufacturing execution and control, and the author presents a concept with different options for improved energy flexibility including battery, compressed air and embodied energy storage. The reader will also find a detailed application procedure as well as an implementation into a simulation prototype software. The book concludes with two case studies. The target audience primarily comprises research experts in the field of green manufacturing systems. .

  20. Medical Robots: Current Systems and Research Directions

    Directory of Open Access Journals (Sweden)

    Ryan A. Beasley

    2012-01-01

    Full Text Available First used medically in 1985, robots now make an impact in laparoscopy, neurosurgery, orthopedic surgery, emergency response, and various other medical disciplines. This paper provides a review of medical robot history and surveys the capabilities of current medical robot systems, primarily focusing on commercially available systems while covering a few prominent research projects. By examining robotic systems across time and disciplines, trends are discernible that imply future capabilities of medical robots, for example, increased usage of intraoperative images, improved robot arm design, and haptic feedback to guide the surgeon.

  1. Analysis of nonlinear systems using ARMA [autoregressive moving average] models

    International Nuclear Information System (INIS)

    Hunter, N.F. Jr.

    1990-01-01

    While many vibration systems exhibit primarily linear behavior, a significant percentage of the systems encountered in vibration and model testing are mildly to severely nonlinear. Analysis methods for such nonlinear systems are not yet well developed and the response of such systems is not accurately predicted by linear models. Nonlinear ARMA (autoregressive moving average) models are one method for the analysis and response prediction of nonlinear vibratory systems. In this paper we review the background of linear and nonlinear ARMA models, and illustrate the application of these models to nonlinear vibration systems. We conclude by summarizing the advantages and disadvantages of ARMA models and emphasizing prospects for future development. 14 refs., 11 figs

  2. Technical note on drainage systems:design of pipes and detention facilities for rainwater

    OpenAIRE

    Bentzen, Thomas Ruby

    2014-01-01

    This technical note will present simple but widely used methods for the design of drainage systems. The note will primarily deal with surface water (rainwater) which on a satisfactorily way should be transport into the drainage system. Traditional two types of sewer systems exist: A combined system, where rainwater and sewage is transported in the same pipe, and a separate system where the two types of water are transported in individual pipe. This note will only focus on the separate rain/st...

  3. The power of habits: unhealthy snacking behaviour is primarily predicted by habit strength.

    Science.gov (United States)

    Verhoeven, Aukje A C; Adriaanse, Marieke A; Evers, Catharine; de Ridder, Denise T D

    2012-11-01

    Although increasing evidence shows the importance of habits in explaining health behaviour, many studies still rely solely on predictors that emphasize the role of conscious intentions. The present study was designed to test the importance of habit strength in explaining unhealthy snacking behaviour in a large representative community sample (N= 1,103). To test our hypothesis that habits are crucial when explaining unhealthy snacking behaviour, their role was compared to the 'Power of Food', a related construct that addresses sensitivity to food cues in the environment. Moreover, the relation between Power of Food and unhealthy snacking habits was assessed. A prospective design was used to determine the impact of habits in relation to intention, Power of Food and a number of demographic variables. One month after filling out the questionnaire, including measures of habit strength and Power of Food, participants reported their unhealthy snacking behaviour by means of a 7-day snack diary. Results showed that habit strength was the most important predictor, outperforming all other variables in explaining unhealthy snack intake. The findings demonstrate that snacking habits provide a unique contribution in explaining unhealthy snacking behaviour, stressing the importance of addressing habit strength in further research and interventions concerning unhealthy snacking behaviour. ©2012 The British Psychological Society.

  4. The power of habits : Unhealthy snacking behaviour is primarily predicted by habit strength

    NARCIS (Netherlands)

    Verhoeven, A.A.C.; Adriaanse, M.A.; Evers, C.; de Ridder, D.T.D.

    2012-01-01

    Objective. Although increasing evidence shows the importance of habits in explaining health behaviour, many studies still rely solely on predictors that emphasize the role of conscious intentions. The present study was designed to test the importance of habit strength in explaining unhealthy

  5. Does fault strengthening in laboratory rock friction experiments really depend primarily upon time and not slip?

    Science.gov (United States)

    Bhattacharya, Pathikrit; Rubin, Allan M.; Beeler, Nicholas M.

    2017-08-01

    The popular constitutive formulations of rate-and-state friction offer two end-member views on whether friction evolves only with slip (Slip law) or with time even without slip (Aging law). While rate stepping experiments show support for the Slip law, laboratory-observed frictional behavior near-zero slip rates has traditionally been inferred as supporting Aging law style time-dependent healing, in particular, from the slide-hold-slide experiments of Beeler et al. (1994). Using a combination of new analytical results and explicit numerical (Bayesian) inversion, we show instead that the slide-hold-slide data of Beeler et al. (1994) favor slip-dependent state evolution during holds. We show that, while the stiffness-independent rate of growth of peak stress (following reslides) with hold duration is a property shared by both the Aging and (under a more restricted set of parameter combinations) Slip laws, the observed stiffness dependence of the rate of stress relaxation during long holds is incompatible with the Aging law with constant rate-state parameters. The Slip law consistently fits the evolution of the stress minima at the end of the holds well, whether fitting jointly with peak stresses or otherwise. But neither the Aging nor Slip laws fit all the data well when a - b is constrained to values derived from prior velocity steps. We also attempted to fit the evolution of stress peaks and minima with the Kato-Tullis hybrid law and the shear stress-dependent Nagata law, both of which, even with the freedom of an extra parameter, generally reproduced the best Slip law fits to the data.

  6. Is cruising along European rivers primarily intended for seniors and workers from Eastern Europe?

    Directory of Open Access Journals (Sweden)

    Erdeji Irma

    2017-01-01

    Full Text Available The subject of the paper is river cruising along the rivers of Europe in Belgium, the Netherlands, Germany, Switzerland, France, Austria, Slovakia, Hungary, Croatia, Serbia, Bulgaria, Romania and Italy. The research needed to determine the trends in terms of consumers and labour force, particularly considering great political and economic changes in Europe (and the world in the last ten years. The aims of the research were set in relation to the following: to determine the profile of a tourist as well as the crew members. This paper is based on empirical and theoretical research. It combines quantitative primary and secondary as well as qualitative data collection (interview. Primary data was collected from the 'Uniworld' company by analysing crew manifests in order to define the demographical profile of the employees. Secondary data collection was used to define the profile of the tourist, where latest relevant publications were consulted. Qualitative method was used to gain more insight in the latest trends of River Cruising by interweaving the managers of the 'Uniworld' company. It was determined that 'baby boomers' are no longer prevalent on the cruise ships, but the 'millennials' cohort are on the rise. Such changes will require a new approach among the cruising companies - in terms of the concept of service delivery and marketing. However, among employees there is no significant change, suggesting that this type of job market is tightly regulated by EU regulations. This research offers valuable data in the field of tourism destination management, as well as the needs of some stakeholders, especially in terms of human resources management and management of strategic development issues. This is important both for the countries which already have positioned themselves on the cruising market as well as for emerging destinations.

  7. Electroejaculation functions primarily by direct activation of pelvic musculature: Perspectives from a porcine model

    Directory of Open Access Journals (Sweden)

    Adam M.R. Groh

    2018-03-01

    Full Text Available Ejaculatory dysfunction is a significant cause of infertility in men that have incurred spinal cord injury or iatrogenic lesions to the sympathetic nerves in the retroperitoneum. For such patients, electroejaculation – whereby a voltage is applied transrectally under general anesthesia – is a highly-effective procedure to obtain ejaculate. At present, however, there remains uncertainty as to the physiological mechanism by which electroejaculation prompts seminal emission in males with neurogenic anejaculation. Thus, in the present study, we aimed to determine, for the first time, whether electroejaculation functions by mimicking a neurophysiological response, or by directly activating local pelvic musculature. Using electroejaculation in a novel porcine model, we monitored the strength of contraction of the internal urethral sphincter (a smooth muscle involved in ejaculation before and after lesioning its sympathetic innervation with a combination of progressively-worsening surgical and pharmacological insults in three anesthetized boars (46.1 ± 7.4 kg. Importantly, prior to this investigation, we confirmed the comparative structural anatomy of the porcine model to humans through gross dissection and histological analysis of the infrarenal retroperitoneal sympathetic nerves and ganglia in 18 unembalmed boars. Prior to sacrifice, three of these boars underwent functional testing to confirm control of the internal urethral sphincter by the hypogastric nerves. Our results demonstrate that electroejaculation-induced contraction of the internal urethral sphincter was preserved following each progressive neural insult compared to the control state (p > 0.05. In contrast, these same insults resulted in paralysis/paresis of the internal urethral sphincter when its sympathetic innervation was directly stimulated with bipolar electrodes (p < 0.05. Taken together, our results provide the first empirical evidence to suggest that electroejaculation does not initiate ejaculation through neural mechanisms, but rather activates pelvic musculature in an independent and non-physiological manner.

  8. South African shore-angling is primarily recrea- tional, and there has ...

    African Journals Online (AJOL)

    spamer

    Inspectorate in the Cape coastal provinces and by the. Natal Parks ..... in the Eastern Cape, general overfishing and beach- seining in the ..... South-Western Cape, with an assessment of the effect of .... Society for Fish Biology: 31–41. Brouwer ...

  9. Effect of primarily cultured human lung cancer-associated fibroblasts on radiosensitivity of lung cancer cells

    International Nuclear Information System (INIS)

    Ji Xiaoqin; Ji Jiang; Chen Yongbing; Shan Fang; Lu Xueguan

    2014-01-01

    Objective: To investigate the effect of human lung cancer-associated fibroblasts (CAF) on the radiosensitivity of lung cancer cells when CAF is placed in direct contact co-culture with lung cancer cells. Methods: Human lung CAF was obtained from fresh human lung adenocarcinoma tissue specimens by primary culture and subculture and was then identified by immunofluorescence staining. The CAF was placed in direct contact co-culture with lung cancer A 549 and H 1299 cells, and the effects of CAF on the radiosensitivity of A 549 and H 1299 cells were evaluated by colony-forming assay. Results: The human lung CAF obtained by adherent culture could stably grow and proliferate, and it had specific expression of α-smooth muscle actin, vimentin, and fibroblast activation protein,but without expression of cytokeratin-18. The plating efficiency (PE, %) of A 549 cells at 0 Gy irradiation was (20.0 ± 3.9)% when cultured alone versus (32.3 ± 5.5)% when co-cultured with CAF (t=3.16, P<0.05), and the PE of H 1299 cells at 0 Gy irradiation was (20.6 ± 3.1)% when cultured alone versus (35.2 ± 2.3)% when co-cultured with CAF (t=6.55, P<0.05). The cell survival rate at 2 Gy irradiation (SF 2 ) of A 549 cells was 0.727 ±0.061 when cultured alone versus 0.782 ± 0.089 when co-cultured with CAF (t=0.88, P>0.05), and the SF 2 of H 1299 cells was 0.692 ±0.065 when cultured alone versus 0.782 ± 0.037 when co-cultured with CAF (t=2.08, P>0.05). The protection enhancement ratios of human lung CAF for A 549 cells and H 1299 cells were 1.29 and 1.25, respectively. Conclusions: Human lung CAF reduces the radiosensitivity of lung cancer cells when placed in direct contact co-culture with them, and the radioprotective effect may be attributed to CAF promoting the proliferation of lung cancer cells. (authors)

  10. Serum and plasma fibronectin binds to complement reacted immune complexes primarily via Clq

    DEFF Research Database (Denmark)

    Baatrup, G; Svehag, S E

    1986-01-01

    The binding of fibronectin to human Clq, C3b, and complement-reacted immune complexes (IC) was investigated by enzyme-linked immunosorbent assays. Microplates were coated with BSA followed by incubation with rabbit-anti-BSA IgG or F(ab')2 fragments of rabbit anti-BSA. Incubation of the solid phase...... with serum at 37 degrees C caused attachment of Clq and C3b. Addition of EDTA to the serum inhibited the binding of C3b, but not Clq, whereas substitution of the anti-BSA IgG on the solid phase with the F(ab')2 fragments abrogated the Clq, but not the C3b binding. Fibronectin binding was observed after...

  11. Search for primarily non-interacting decay modes of the upsilon

    International Nuclear Information System (INIS)

    Leffler, J.S.

    1986-03-01

    The hadronic transition UPSILON(2S) → π 0 π 0 UPSILON(1S) is utilized to search for the reactions: UPSILON(1S) → non-interacting particles and UPSILON(1S) → γ + non-interacting particles. 44 pb -1 of UPSILON(2S) data were taken by the Crystal Ball detector at the DORIS II storage ring in order to perform this study. An upper limit of BR(UPSILON → Unseen) -1 of UPSILON(2S) data was available for this study. An upper limit on the branching ratio BR(UPSILON → γ + Unseen) is measured for photon energies in the range 500 MeV -3 (90% C.L.), is obtained. The compact size of the Crystal Ball detector enhances the observable branching ratio for noninteracting particles with short lifetimes such as massive axions. The identification of the recent Darmstadt events with a 1.6 MeV axion is excluded by the present result assuming the minimal Peccei-Quinn model. Limits on the spontaneous supersymmetry breaking mass scale are also derived as a function of gravitino mass

  12. FudC, a protein primarily responsible for furfural detoxification in Corynebacterium glutamicum.

    Science.gov (United States)

    Tsuge, Yota; Kudou, Motonori; Kawaguchi, Hideo; Ishii, Jun; Hasunuma, Tomohisa; Kondo, Akihiko

    2016-03-01

    Lignocellulosic hydrolysates contain compounds that inhibit microbial growth and fermentation, thereby decreasing the productivity of biofuel and biochemical production. In particular, the heterocyclic aldehyde furfural is one of the most toxic compounds found in these hydrolysates. We previously demonstrated that Corynebacterium glutamicum converts furfural into the less toxic compounds furfuryl alcohol and 2-furoic acid. To date, however, the genes involved in these oxidation and reduction reactions have not been identified in the C. glutamicum genome. Here, we show that Cgl0331 (designated FudC) is mainly responsible for the reduction of furfural into furfuryl alcohol in C. glutamicum. Deletion of the gene encoding FudC markedly diminished the in vivo reduction of furfural to furfuryl alcohol. Purified His-tagged FudC protein from Escherichia coli was also shown to convert furfural into furfuryl alcohol in an in vitro reaction utilizing NADPH, but not NADH, as a cofactor. Kinetic measurements demonstrated that FudC has a high affinity for furfural but has a narrow substrate range for other aldehydes compared to the protein responsible for furfural reduction in E. coli.

  13. 26 CFR 25.2502-2 - Donor primarily liable for tax.

    Science.gov (United States)

    2010-04-01

    ... extent of the value of their inheritances, bequests, devises, or distributive shares of the donor's... third party during any “calendar period” (as defined in § 25.2502-1(c)(1)) considered as made one-half... much thereof as may remain due and unpaid. As used in such section 3467, the word “debt” includes a...

  14. Detection of prosecretory mitogen lacritin in nonprimate tears primarily as a C-terminal-like fragment.

    Science.gov (United States)

    Laurie, Diane E; Splan, Rebecca K; Green, Kari; Still, Katherine M; McKown, Robert L; Laurie, Gordon W

    2012-09-12

    Lacritin is a human tear glycoprotein that promotes basal tear protein secretion in cultured rat lacrimal acinar cells and proliferation of subconfluent human corneal epithelial cells. When topically added to rabbit eyes, lacritin promotes basal tearing. Despite these activities on several species, lacritin's presence in nonprimate tears or other tissues has not been explored. Here we probed for lacritin in normal horse tears. Sequences were collected from the Ensembl genomic alignment of human LACRT gene with high-quality draft horse genome (EquCab2.0) and analyzed. Normal horse tears were collected and assayed by Western blotting, ELISA, and mass spectrometry. Newly generated rabbit antibodies, respectively, against N- and C-terminal regions of human lacritin were employed. Identity was 75% and 45%, respectively, at nucleotide and protein levels. Structural features were conserved, including a C-terminal amphipathic α-helix. Anti-C-terminal antibodies strongly detected a ∼13 kDa band in horse tears that was validated by mass spectrometry. In human tears, the same antibody detected uncleaved lacritin (∼24 kDa) strongly and C-terminal fragments of ∼13 and ∼11 kDa weakly. Anti-N-terminal antibodies were slightly reactive with a ∼24 kDa horse antigen and showed no reaction with the anti-C-terminal-reactive ∼13 kDa species. Similar respective levels of horse C-terminal versus N-terminal immunoreactivity were apparent by ELISA. Lacritin is present in horse tears, largely as a C-terminal fragment homologous to the mitogenic and bactericidal region in human lacritin, suggesting potential benefit in corneal wound repair.

  15. Respiratory Polysomnographic Findings in Patients Treated Primarily for Unilateral Cleft Lip and Palate.

    Science.gov (United States)

    Sobral, Davi Sandes; Faller, Gustavo Juliane; Collares, Marcus Vinícius Martins

    2018-02-01

    Cleft lip and palate (CLP) is the most common congenital craniofacial abnormality. Obstructive sleep apnea syndrome (OSAS) is a highly prevalent but underdiagnosed disease and is frequently associated with craniofacial anomalies. There are few studies describing the sleep breathing pattern of children with CLP. This study sought to characterize the respiratory profile of 23 children with unilateral cleft lip and palate, aged 7-12 years, who had undergone cleft lip and nasal repair at age 3-4 months and palatoplasty at 12-15 months, with a particular focus on evaluating the presence of OSAS in children with CLP. Polysomnography was performed and findings were analyzed descriptively. We found a mean and median for apnea/hypopnea index (AHI) of 1.11/h (SD = 0.78) and 0.9/h, respectively. The mean obstructive apnea index (OAI) was 0.27/h (SD = 0.38) and the median, 0.1/h. Nearly 30% of patients had an AHI above 1.4 events/h. There was no significant oxyhemoglobin desaturation in the study group. In this group, the prevalence of OSAS was higher than in noncleft populations when compared to the normality values adopted. This sample of patients with unilateral cleft lip and palate exhibited an increased prevalence of OSAS during the mixed dentition stage. Although the results showed that OSAS was mild, we advise closer observation of these patients. Polysomnography is recommended for the assessment of children with airway abnormalities, to individualize the extent of treatment.

  16. Surtsey research progress report. VII. Primarily 1971 and 1972 field seasons

    Energy Technology Data Exchange (ETDEWEB)

    1974-01-01

    The volcanic island, Surtsey, approximately 20 miles off the south coast of Iceland is unique as the most recent addition to Iceland. It is even more unique for the fact that it has from its birth been strictly protected as a nature reserve. Extensive scientific studies started as soon as the island was formed. The report covers work done on Surtsey since the publication of the last report in April 1972. Individual abstracts were entered for the 9 sections of the report.

  17. Pregnant women in Timis County, Romania are exposed primarily to low-level (water consumption.

    Science.gov (United States)

    Neamtiu, Iulia; Bloom, Michael S; Gati, Gabriel; Goessler, Walter; Surdu, Simona; Pop, Cristian; Braeuer, Simone; Fitzgerald, Edward F; Baciu, Calin; Lupsa, Ioana Rodica; Anastasiu, Doru; Gurzau, Eugen

    2015-06-01

    Excessive arsenic content in drinking water poses health risks to millions of people worldwide. Inorganic arsenic (iAs) in groundwater exceeding the 10μg/l maximum contaminant level (MCL) set by the World Health Organization (WHO) is characteristic for intermediate-depth aquifers over large areas of the Pannonian Basin in Central Europe. In western Romania, near the border with Hungary, Arad, Bihor, and Timis counties use drinking water coming partially or entirely from iAs contaminated aquifers. In nearby Arad and Bihor counties, more than 45,000 people are exposed to iAs over 10μg/l via public drinking water sources. However, comparable data are unavailable for Timis County. To begin to address this data gap, we determined iAs in 124 public and private Timis County drinking water sources, including wells and taps, used by pregnant women participating in a case-control study of spontaneous loss. Levels in water sources were low overall (median=3.0; range=water sources compared to 10 women using uncontaminated sources for urine total iAs (6.6 vs. 5.0μg/l, P=0.24) and DMA (5.5 vs. 4.2μg/l, P=0.31). The results suggested that the origin of urine total iAs (r=0.35, P=0.13) and DMA (r=0.31, P=0.18) must have been not only iAs in drinking-water but also some other source. Exposure of pregnant women to arsenic via drinking water in Timis County appears to be lower than for surrounding counties; however, it deserves a more definitive investigation as to its origin and the regional distribution of its risk potential. Copyright © 2015 Elsevier GmbH. All rights reserved.

  18. [Fall from height--surprising autopsy diagnosis in primarily unclear initial situations].

    Science.gov (United States)

    Schyma, Christian; Doberentz, Elke; Madea, Burkhard

    2012-01-01

    External post-mortem examination and first police assessments are often not consistent with subsequent autopsy results. This is all the more surprising the more serious the injuries found at autopsy are. Such discrepancies result especially from an absence of gross external injuries, as demonstrated by four examples. A 42-year-old, externally uninjured male was found at night time in a helpless condition in the street and died in spite of resuscitation. Autopsy showed severe polytrauma with traumatic brain injury and lesions of the thoracic and abdominal organs. A jump from the third floor was identified as the cause. At dawn, a twenty-year-old male was found dead on the grounds of the adjacent house. Because of the blood-covered head the police assumed a traumatic head injury by strike impact. The external examination revealed only abrasions on the forehead and to a minor extent on the back. At autopsy a midfacial fracture, a trauma of the thorax and abdomen and fractures of the spine and pelvis were detected. Afterwards investigations showed that the man, intoxicated by alcohol, had fallen from the flat roof of a multistoried house. A 77-year-old man was found unconscious on his terrace at day time; a cerebral seizure was assumed. He was transferred to emergency care where he died. The corpse was externally inconspicuous. Autopsy revealed serious traumatic injuries of the brain, thorax, abdomen and pelvis, which could be explained by a fall from the balcony. A 47-year-old homeless person without any external injuries was found dead in a barn. An alcohol intoxication was assumed. At autopsy severe injuries of the brain and cervical spine were found which were the result of a fall from a height of 5 m. On the basis of an external post-mortem examination alone gross blunt force trauma cannot be reliably excluded.

  19. New species and host plants of Anastrepha (Diptera: Tephritidae) primarily from Peru and Bolivia

    Science.gov (United States)

    Twenty-eight new species of Anastrepha are described and illustrated: A. acca (Bolivia, Peru), A. adami (Peru), A. amplidentata (Bolivia, Peru), A. annonae (Peru), A. breviapex (Peru), A. caballeroi (Peru), A. camba (Bolivia, Peru), A. cicra (Bolivia, Peru), A. disjuncta (Peru), A. durantae (Peru), ...

  20. Sustained attention failures are primarily due to sustained cognitive load not task monotony.

    Science.gov (United States)

    Head, James; Helton, William S

    2014-11-01

    We conducted two studies using a modified sustained attention to response task (SART) to investigate the developmental process of SART performance and the role of cognitive load on performance when the speed-accuracy trade-off is controlled experimentally. In study 1, 23 participants completed the modified SART (target stimuli location was not predictable) and a subjective thought content questionnaire 4 times over the span of 4 weeks. As predicted, the influence of speed-accuracy trade-off was significantly mitigated on the modified SART by having target stimuli occur in unpredictable locations. In study 2, 21 of the 23 participants completed an abridged version of the modified SART with a verbal free-recall memory task. Participants performed significantly worse when completing the verbal memory task and SART concurrently. Overall, the results support a resource theory perspective with concern to errors being a result of limited mental resources and not simply mindlessness per se. Copyright © 2014. Published by Elsevier B.V.

  1. Amazonian Amphibian Diversity Is Primarily Derived from Late Miocene Andean Lineages

    Science.gov (United States)

    Santos, Juan C; Coloma, Luis A; Summers, Kyle; Caldwell, Janalee P; Ree, Richard; Cannatella, David C

    2009-01-01

    The Neotropics contains half of remaining rainforests and Earth's largest reservoir of amphibian biodiversity. However, determinants of Neotropical biodiversity (i.e., vicariance, dispersals, extinctions, and radiations) earlier than the Quaternary are largely unstudied. Using a novel method of ancestral area reconstruction and relaxed Bayesian clock analyses, we reconstructed the biogeography of the poison frog clade (Dendrobatidae). We rejected an Amazonian center-of-origin in favor of a complex connectivity model expanding over the Neotropics. We inferred 14 dispersals into and 18 out of Amazonia to adjacent regions; the Andes were the major source of dispersals into Amazonia. We found three episodes of lineage dispersal with two interleaved periods of vicariant events between South and Central America. During the late Miocene, Amazonian, and Central American-Chocoan lineages significantly increased their diversity compared to the Andean and Guianan-Venezuelan-Brazilian Shield counterparts. Significant percentage of dendrobatid diversity in Amazonia and Chocó resulted from repeated immigrations, with radiations at Venezuelan Highlands, and Guiana Shield have undergone extended in situ diversification at near constant rate since the Oligocene. The effects of Miocene paleogeographic events on Neotropical diversification dynamics provided the framework under which Quaternary patterns of endemism evolved. PMID:19278298

  2. The serotonin transporter undergoes constitutive internalization and is primarily sorted to late endosomes and lysosomal degradation

    DEFF Research Database (Denmark)

    Rahbek-Clemmensen, Troels; Bay, Tina; Eriksen, Jacob

    2014-01-01

    The serotonin transporter (SERT) plays a critical role in regulating serotonin signaling by mediating reuptake of serotonin from the extracellular space. The molecular and cellular mechanisms controlling SERT levels in the membrane remain poorly understood. To study trafficking of surface resident...... SERT, two functional epitope tagged variants were generated. Fusion of a FLAG-tagged one-transmembrane segment protein Tac to the SERT N-terminus generated a transporter with an extracellular epitope suited for trafficking studies (TacSERT). Likewise, a construct with an extracellular antibody epitope...

  3. American Samoa: coral reef monitoring interactive map and information layers primarily from 2010 surveys

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This interactive map displays American Samoa data collected by the NOAA Coral Reef Ecosystem Division (CRED) during the Pacific Reef Assessment and Monitoring...

  4. Through the Loupe: Visitor engagement with a primarily text-based handheld AR application

    NARCIS (Netherlands)

    van der Vaart, M.; Damala, A.; Guidi, G; Scopigno, R.; Torres, J.C.; Graf, H.; Remondino, F.; Duranti, L.; Brunet, P.; Hazan, S.; Barceló, J.

    2015-01-01

    The use of Augmented Reality (AR) in a museum or heritage setting holds great potential. However, until now, introducing AR into their buildings has been prohibitively expensive for most museums. On the one hand, programming the AR application could not be done in-house and would be rather costly.

  5. Why we cannot conclude that sexual orientation is primarily a biological phenomenon.

    Science.gov (United States)

    Byne, W

    1997-01-01

    While all mental phenomena must have an ultimate biological substrate, the precise contribution of biological factors to the development of sexual orientation remains to be elucidated. Does biology merely provide the slate of neural circuitry upon which sexual orientation is inscribed by experience? Do biological factors directly wire the brain so that it will support a particular orientation? Or do biological factors influence sexual orientation only indirectly, perhaps by influencing personality variables that in turn influence how one interacts with and shapes the environment as it contributes to the social relationships and experiences that shape sexual orientation as it emerges developmentally? Recent neurostructural and genetic linkage evidence pertaining to sexual orientation must be viewed tentatively until it has been adequately corroborated and integrated with psychological and cultural models. Moreover, even a reliable and robust correlation between a biological marker and sexual orientation would be equally compatible with the second and third possibilities delineated above. Yet if the third possibility more closely approximates reality, the search for predisposing biological factors will result in incomplete and misleading findings until their interactions with environmental factors are taken into account and controlled for in adequate longitudinal studies.

  6. New species and host plants of Anastrepha (Diptera: Tephritidae) primarily from Peru and Bolivia.

    Science.gov (United States)

    Norrbom, Allen L; Rodriguez, Erick J; Steck, Gary J; Sutton, Bruce A; Nolazco, Norma

    2015-11-16

    Twenty-eight new species of Anastrepha are described and illustrated: A. acca (Bolivia, Peru), A. adami (Peru), A. amplidentata (Bolivia, Peru), A. annonae (Peru), A. breviapex (Peru), A. caballeroi (Peru), A. camba (Bolivia, Peru), A. cicra (Bolivia, Peru), A. disjuncta (Peru), A. durantae (Peru), A. echaratiensis (Peru), A. eminens (Peru), A. ericki (Peru), A. gonzalezi (Bolivia, Peru), A. guevarai (Peru), A. gusi (Peru), A. kimi (Colombia, Peru), A. korytkowskii (Bolivia, Peru), A. latilanceola (Bolivia, Peru), A. melanoptera (Peru), A. mollyae (Bolivia, Peru), A. perezi (Peru), A. psidivora (Peru), A. robynae (Peru), A. rondoniensis (Brazil, Peru), A. tunariensis (Bolivia, Peru), A. villosa (Bolivia), and A. zacharyi (Peru). The following host plant records are reported: A. amplidentata from Spondias mombin L. (Anacardiaceae); A. caballeroi from Quararibea malacocalyx A. Robyns & S. Nilsson (Malvaceae); A. annonae from Annona mucosa Jacq. and Annona sp. (Annonaceae); A. durantae from Duranta peruviana Moldenke (Verbenaceae); and A. psidivora from Psidium guajava L. (Myrtaceae).

  7. Primarily Statistics: Developing an Introductory Statistics Course for Pre-Service Elementary Teachers

    Science.gov (United States)

    Green, Jennifer L.; Blankenship, Erin E.

    2013-01-01

    We developed an introductory statistics course for pre-service elementary teachers. In this paper, we describe the goals and structure of the course, as well as the assessments we implemented. Additionally, we use example course work to demonstrate pre-service teachers' progress both in learning statistics and as novice teachers. Overall, the…

  8. Tribolium castaneum defensins are primarily active against Gram-positive bacteria

    Czech Academy of Sciences Publication Activity Database

    Tonk, M.; Knorr, E.; Cabezas-Cruz, A.; Valdés, James J.; Kollewe, C.; Vilcinskas, A.

    2015-01-01

    Roč. 132, NOV 2015 (2015), s. 208-215 ISSN 0022-2011 R&D Projects: GA MŠk(CZ) EE2.3.30.0032 Institutional support: RVO:60077344 Keywords : Antimicrobial peptides * Defensin * Innate immunity * Insects * Tribolium castaneum * Gram-positive bacteria Subject RIV: EI - Biotechnology ; Bionics Impact factor: 2.198, year: 2015

  9. Disgust sensitivity is primarily associated with purity-based moral judgments

    NARCIS (Netherlands)

    Wagemans, F.M.A.; Brandt, M.J.; Zeelenberg, M.

    2018-01-01

    Individual differences in disgust sensitivity are associated with a range of judgments and attitudes related to the moral domain. Some perspectives suggest that the association between disgust sensitivity and moral judgments will be equally strong across all moral domains (i.e., purity, authority,

  10. Parasites Affect Food Web Structure Primarily through Increased Diversity and Complexity

    NARCIS (Netherlands)

    Dunne, J.A.; Lafferty, K.D.; Dobson, A.P.; Hechinger, R.F.; Kuris, A.M.; Martinez, N.D.; McLaughlin, J.P.; Mouritsen, K.N.; Poulin, R.; Reise, K.; Stouffer, D.B.; Thieltges, D.W.; Williams, R.J.; Zander, C.D.

    2013-01-01

    Comparative research on food web structure has revealed generalities in trophic organization, produced simple models, and allowed assessment of robustness to species loss. These studies have mostly focused on free-living species. Recent research has suggested that inclusion of parasites alters

  11. LMFBR operational and experimental local-fault experience, primarily with oxide fuel elements

    International Nuclear Information System (INIS)

    Warinner, D.K.

    1980-01-01

    Case-by-case reviews of selective world experience with severe local faults, particularly fuel failure and fuel degradation, are reviewed for two sodium-cooled thermal reactors, several LMFBRs, and LMFBR-fuels experiments. The review summarizes fuel-failure frequency and illustrates the results of the most damaging LMFBR local-fault experiences of the last 20 years beginning with BR-5 and including DFR, BOR-60, BR2's MFBS- and Mol-loops experiments, Fermi, KNK, Rapsodie, EBR-II, and TREAT-D2. Local-fault accommodation is demonstrated and a need to more thoroughly investigate delayed-neutron and gaseous-fission-product signals is highlighted in view of uranate formation, observed blockages, and slow fuel-element failure-propagation

  12. Biking practices and preferences in a lower income, primarily minority neighborhood: Learning what residents want.

    Science.gov (United States)

    Lusk, Anne C; Anastasio, Albert; Shaffer, Nicholas; Wu, Juan; Li, Yanping

    2017-09-01

    This paper examines if, in a lower-income minority neighborhood, bicycling practices and bicycle-environment preferences of Blacks and Hispanics were different from Whites. During the summer of 2014, surveys were mailed to 1537 households near a proposed cycle track on Malcolm X Boulevard in Roxbury, MA. On the Boulevard, intercept surveys were distributed to cyclists and observations noted about passing cyclist's characteristics. Data were analyzed from 252 returned-mailed surveys, 120 intercept surveys, and 709 bicyclists. White (100%), Hispanic (79%), and Black (76%) bicyclists shown pictures of 6 bicycle facility types in intercept surveys perceived the cycle track as safest. More White mailed-survey respondents thought bikes would not be stolen which may explain why more Hispanics (52%) and Blacks (47%) preferred to park their bikes inside their home compared with Whites (28%), with H/W B/W differences statistically significant ( p  bike compared with Whites (75%). Minority populations are biking on roads but prefer cycle tracks. They also prefer to park bikes inside their homes and bicycle with family and friends. Wide cycle tracks (bicycling with family/friends) and home bike parking should be targeted as capital investments in lower-income minority neighborhoods.

  13. Biking practices and preferences in a lower income, primarily minority neighborhood: Learning what residents want

    Directory of Open Access Journals (Sweden)

    Anne C. Lusk

    2017-09-01

    Full Text Available This paper examines if, in a lower-income minority neighborhood, bicycling practices and bicycle-environment preferences of Blacks and Hispanics were different from Whites. During the summer of 2014, surveys were mailed to 1537 households near a proposed cycle track on Malcolm X Boulevard in Roxbury, MA. On the Boulevard, intercept surveys were distributed to cyclists and observations noted about passing cyclist's characteristics. Data were analyzed from 252 returned-mailed surveys, 120 intercept surveys, and 709 bicyclists. White (100%, Hispanic (79%, and Black (76% bicyclists shown pictures of 6 bicycle facility types in intercept surveys perceived the cycle track as safest. More White mailed-survey respondents thought bikes would not be stolen which may explain why more Hispanics (52% and Blacks (47% preferred to park their bikes inside their home compared with Whites (28%, with H/W B/W differences statistically significant (p < 0.05. More Hispanic (81% and Black (54% mailed-survey respondents thought they would bicycle more if they could bicycle with family and friends compared with Whites (40%. Bicyclists observed commuting morning and evening included Blacks (55%, Whites (36% and Hispanics (9%. More Whites (68% wore helmets compared with Hispanics (21% and Blacks (17% (p < 0.001. More Blacks (94% and Hispanics (94% rode a mountain bike compared with Whites (75%. Minority populations are biking on roads but prefer cycle tracks. They also prefer to park bikes inside their homes and bicycle with family and friends. Wide cycle tracks (bicycling with family/friends and home bike parking should be targeted as capital investments in lower-income minority neighborhoods.

  14. LMFBR operational and experimental in-core local-fault experience, primarily with oxide fuel elements

    International Nuclear Information System (INIS)

    Warinner, D.K.

    Case-by-case reviews of selective world experience with severe local faults, particularly fuel failure and fuel degradation, are reviewed for two sodium-cooled thermal reactors, several LMFBRs, and LMFBR-fuels experiments. The review summarizes fuel-failure frequency and illustrates the results of the most damaging LMFBR local-fault experiences of the last 20 years beginning with BR-5 and including DFR, BOR-60, BR2's MFBS-and Mol-loops experiments, Fermi, KNK, Rapsodie, EBR-II, and TREAT-D2. Local-fault accommodation is demonstrated and a need to more thoroughly investigate delayed-neutron and gaseous-fission-product signals is highlighted in view of uranate formation, observed blockages, and slow fuel-element failure-propagation

  15. Home range and food habits of Pacific reef sharks (primarily the gray reef shark, Carcharhinus amblyrhynchos)

    International Nuclear Information System (INIS)

    Nelson, D.R.; McKibben, J.N.; Tricas, T.C.; Cooksey, D.J.

    1979-01-01

    Progress is reported on the following studies: determining home range dimensions and stabilities by tracking sharks equipped with ultrasonic transmitters; telemetry instrumentation and techniques for applicability under Enewetak conditions; studies on social behavior, especially aggression toward divers, in relation to space utilization and group organization; and compilation of food-habit data from examination of stomach contents

  16. Experiences of LGBTQ Students at a Primarily White Institution in the South

    Science.gov (United States)

    Cain, Leia Kristin

    2015-01-01

    In the United States, often Lesbian, Gay, Bisexual, Transgender, Queer, and/or Questioning (LGBTQ) students are targets of verbal harassment and violence due to their sexual orientation or gender identity and gender expression. Further, 31 states do not offer protection against sexuality- or gender identity-based discrimination (ACLU, 2015).…

  17. Two DNA glycosylases in Esherichia coli which release primarily 3-methyladenine

    International Nuclear Information System (INIS)

    Thomas, L.; Yang, C.; Goldthwait, D.A.

    1982-01-01

    Two enzymes have been partially purified from Escherichia coli and designated 3-methyladenine DNA glycosylases I and II. The apparent molecular weight of glycosylase I is 20,000, and that of II is 27,000. Glycosylase I releases 3-methyladenine (3-MeA) while II releases 3-MeA, 3-methylguanine (3-MeG), 7-methylguanine (7-MeG), and 7-methyladenine (7-MeA). The rate of release of 3-MeA by glycosylase II is 30 times that of 7-MeG. Glycosylase I is missing in mutants tag 1 and tag 2. In crude extracts, the 3-MeA activity of II is approximately 10% of the total 3-MeA activity. A 50% inactivation at 48 0 C required 5 min for I and 65 min for II. The 3-MeA and 7-MeG activities of the glycosylase II preparation could not be separated by isoelectric focusing, by chromatography of DEAE, Sephadex G-100, phosphocellulose, DNA-cellulose, or carboxymethylcellulose, or by heating at 50 0 C

  18. Which sensory perception is primarily considered, in consumers’ hedonic evaluation of foods?

    DEFF Research Database (Denmark)

    Andersen, Barbara Vad; Brockhoff, Per B.; Hyldig, Grethe

    An analysis of the primary hedonic drivers of liking and sensory satisfaction will provide valuable information to product developers on which sensory properties to emphasise the most. The aims of the present study were: a) to study if liking of the sensory properties: appearance, odour, taste...... with sensory profiling. For data analysis mixed three-way analysis of variance and principal component analysis was applied to study and visualise sensory differences. The relative importance of liking of sensory properties; appearance, odour, taste and texture was analysed using slopes, when consumers rated...... and texture were considered equally, when consumers rated overall liking and sensory satisfaction b) to study if the relation depended on, whether liking of sensory properties were related to overall liking or sensory satisfaction, and c) to study individual differences in which sensory properties...

  19. OPA3, mutated in 3-methylglutaconic aciduria type III, encodes two transcripts targeted primarily to mitochondria

    DEFF Research Database (Denmark)

    Huizing, Marjan; Dorward, Heidi; Ly, Lien

    2010-01-01

    3-Methylglutaconic aciduria type III (3-MGCA type III), caused by recessive mutations in the 2-exon gene OPA3, is characterized by early-onset bilateral optic atrophy, later-onset extrapyramidal dysfunction, and increased urinary excretion of 3-methylglutaconic acid and 3-methylglutaric acid. Her...... in the mitochondrion rather than the peroxisome and implicate loss of OPA3A rather than gain of OPA3B in disease etiology....

  20. Hydrogen peroxide production is not primarily increased in human myotubes established from type 2 diabetic subjects

    DEFF Research Database (Denmark)

    Minet, A D; Gaster, M

    2011-01-01

    Increased oxidative stress and mitochondrial dysfunction have been implicated in the development of insulin resistance in type 2 diabetes. To date, it is unknown whether increased mitochondrial reactive oxygen species (ROS) production in skeletal muscle from patients with type 2 diabetes is prima......Increased oxidative stress and mitochondrial dysfunction have been implicated in the development of insulin resistance in type 2 diabetes. To date, it is unknown whether increased mitochondrial reactive oxygen species (ROS) production in skeletal muscle from patients with type 2 diabetes...

  1. National Health Expenditure Projections, 2017-26: Despite Uncertainty, Fundamentals Primarily Drive Spending Growth.

    Science.gov (United States)

    Cuckler, Gigi A; Sisko, Andrea M; Poisal, John A; Keehan, Sean P; Smith, Sheila D; Madison, Andrew J; Wolfe, Christian J; Hardesty, James C

    2018-03-01

    Under current law, national health spending is projected to grow 5.5 percent annually on average in 2017-26 and to represent 19.7 percent of the economy in 2026. Projected national health spending and enrollment growth over the next decade is largely driven by fundamental economic and demographic factors: changes in projected income growth, increases in prices for medical goods and services, and enrollment shifts from private health insurance to Medicare that are related to the aging of the population. The recent enactment of tax legislation that eliminated the individual mandate is expected to result in only a small reduction to insurance coverage trends.

  2. CO2 leakage-induced vegetation decline is primarily driven by decreased soil O2.

    Science.gov (United States)

    Zhang, Xueyan; Ma, Xin; Zhao, Zhi; Wu, Yang; Li, Yue

    2016-04-15

    To assess the potential risks of carbon capture and storage (CCS), studies have focused on vegetation decline caused by leaking CO2. Excess soil CO2 caused by leakage can affect soil O2 concentrations and soil pH, but how these two factors affect plant development remains poorly understood. This hinders the selection of appropriate species to mitigate potential negative consequences of CCS. Through pot experiments, we simulated CO2 leakage to examine its effects on soil pH and soil O2 concentrations. We subsequently assessed how maize growth responded to these changes in soil pH and O2. Decreased soil O2 concentrations significantly reduced maize biomass, and explained 69% of the biomass variation under CO2 leakage conditions. In contrast, although leaked CO2 changed soil pH significantly (from 7.32 to 6.75), it remained within the optimum soil pH range for maize growth. This suggests that soil O2 concentration, not soil pH, influences plant growth in these conditions. Therefore, in case of potential CO2 leakage risks, hypoxia-tolerant species should be chosen to improve plant survival, growth, and yield. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Culturable bioaerosols along an urban waterfront are primarily associated with coarse particles

    Directory of Open Access Journals (Sweden)

    Angel Montero

    2016-12-01

    Full Text Available The source, characteristics and transport of viable microbial aerosols in urban centers are topics of significant environmental and public health concern. Recent studies have identified adjacent waterways, and especially polluted waterways, as an important source of microbial aerosols to urban air. The size of these aerosols influences how far they travel, their resistance to environmental stress, and their inhalation potential. In this study, we utilize a cascade impactor and aerosol particle monitor to characterize the size distribution of particles and culturable bacterial and fungal aerosols along the waterfront of a New York City embayment. We seek to address the potential contribution of bacterial aerosols from local sources and to determine how their number, size distribution, and taxonomic identity are affected by wind speed and wind direction (onshore vs. offshore. Total culturable microbial counts were higher under offshore winds (average of 778 CFU/m3 ± 67, with bacteria comprising the majority of colonies (58.5%, as compared to onshore winds (580 CFU/m3 ± 110 where fungi were dominant (87.7%. The majority of cultured bacteria and fungi sampled during both offshore winds (88% and onshore winds (72% were associated with coarse aerosols (>2.1 µm, indicative of production from local sources. There was a significant correlation (p < 0.05 of wind speed with both total and coarse culturable microbial aerosol concentrations. Taxonomic analysis, based on DNA sequencing, showed that Actinobacteria was the dominant phylum among aerosol isolates. In particular, Streptomyces and Bacillus, both spore forming genera that are often soil-associated, were abundant under both offshore and onshore wind conditions. Comparisons of bacterial communities present in the bioaerosol sequence libraries revealed that particle size played an important role in microbial aerosol taxonomy. Onshore and offshore coarse libraries were found to be most similar. This study demonstrates that the majority of culturable bacterial aerosols along a New York City waterfront were associated with coarse aerosol particles, highlighting the importance of local sources, and that the taxonomy of culturable aerosol bacteria differed by size fraction and wind direction.

  4. Parasites affect food web structure primarily through increased diversity and complexity.

    Directory of Open Access Journals (Sweden)

    Jennifer A Dunne

    Full Text Available Comparative research on food web structure has revealed generalities in trophic organization, produced simple models, and allowed assessment of robustness to species loss. These studies have mostly focused on free-living species. Recent research has suggested that inclusion of parasites alters structure. We assess whether such changes in network structure result from unique roles and traits of parasites or from changes to diversity and complexity. We analyzed seven highly resolved food webs that include metazoan parasite data. Our analyses show that adding parasites usually increases link density and connectance (simple measures of complexity, particularly when including concomitant links (links from predators to parasites of their prey. However, we clarify prior claims that parasites "dominate" food web links. Although parasites can be involved in a majority of links, in most cases classic predation links outnumber classic parasitism links. Regarding network structure, observed changes in degree distributions, 14 commonly studied metrics, and link probabilities are consistent with scale-dependent changes in structure associated with changes in diversity and complexity. Parasite and free-living species thus have similar effects on these aspects of structure. However, two changes point to unique roles of parasites. First, adding parasites and concomitant links strongly alters the frequency of most motifs of interactions among three taxa, reflecting parasites' roles as resources for predators of their hosts, driven by trophic intimacy with their hosts. Second, compared to free-living consumers, many parasites' feeding niches appear broader and less contiguous, which may reflect complex life cycles and small body sizes. This study provides new insights about generic versus unique impacts of parasites on food web structure, extends the generality of food web theory, gives a more rigorous framework for assessing the impact of any species on trophic organization, identifies limitations of current food web models, and provides direction for future structural and dynamical models.

  5. 12 CFR 225.127 - Investment in corporations or projects designed primarily to promote community welfare.

    Science.gov (United States)

    2010-01-01

    .... For bank holding companies that file the FR Y-9C (Consolidated Financial Statements for Bank Holding... the FR Y-SP (Parent Company Only Financial Statements for Small Bank Holding Companies), an... CONTROL (REGULATION Y) Regulations Financial Holding Companies Interpretations § 225.127 Investment in...

  6. Temperature sensitivity indicates that chlorination of organic matter in forest soil is primarily biotic.

    Science.gov (United States)

    Bastviken, David; Svensson, Teresia; Karlsson, Susanne; Sandén, Per; Oberg, Gunilla

    2009-05-15

    Old assumptions that chloride is inert and that most chlorinated organic matter in soils is anthropogenic have been challenged by findings of naturally formed organochlorines. Such natural chlorination has been recognized for several decades, but there are still very few measurements of chlorination rates or estimates of the quantitative importance of terrestrial chlorine transformations. While much is known about the formation of specific compounds, bulk chlorination remains poorly understood in terms of mechanisms and effects of environmental factors. We quantified bulk chlorination rates in coniferous forest soil using 36Cl-chloride in tracer experiments at different temperatures and with and without molecular oxygen (O2). Chlorination was enhanced by the presence of O2 and had a temperature optimum at 20 degrees C. Minimum rates were found at high temperatures (50 degrees C) or under anoxic conditions. The results indicate (1) that most of the chlorination between 4 and 40 degrees C was biotic and driven by O2 dependent enzymes, and (2) that there is also slower background chlorination occurring under anoxic conditions at 20 degrees C and under oxic conditions at 50 degrees C. Hence, while oxic and biotic chlorination clearly dominated, chlorination by other processes including possible abiotic reactions was also detected.

  7. Examination of occupational exposure to medical staff (primarily nurses) during 131I medical treatments

    International Nuclear Information System (INIS)

    Watanabe, Masayoshi; Ishikawa, Naofumi; Ito, Kunihiko; Ito, Koichi

    2004-01-01

    Recently, a new amendment to protect against radiation damage to humans has been enacted based on a 1990 recommendation by the International Commission on Radiological Protection (ICRP). Consequently, the dose limits of occupational exposure to medical staff were cut down sharply compared with conventional readjustments. This amended bill, however, may be triggering a reduction in the number of applicants, which hope to engage in radiotherapy. This being the case, we measured the dose levels of the occupational exposure to medical staff (doctor's group, nuclear medicine technologist's group, nurse's group and pharmacist's group) from 1999 to 2002. Moreover, we investigated what the main factor is in nurse's occupational exposure to 131 I. The highest doses of occupational exposure were 3.640 mSv to doctors, 7.060 mSv to nuclear medicine technologists, 1.486 mSv to nurses and 0.552 mSv to pharmacists. According to our results, it was clear that the highest doses in each group were far below the legally mandated upper limits of exposure doses. Although we investigated the correlations between the factors of nurse's occupational exposure to 131 I with the number of inpatients, the amount of 131 I and the number of servicing times for patients, there were no correlations found. Furthermore, to analyzing the factors in detail, it became clear that the main factor in the nurse's occupational exposure was due to the existence of patients who needed many more servicing times for their care than ordinary patients. (author)

  8. Sub-micrometre Particulate Matter is Primarily in Liquid Form over Amazon Rainforests

    Energy Technology Data Exchange (ETDEWEB)

    Bateman, Adam P.; Gong, Z. H.; Liu, Pengfei; Sato, Bruno; Cirino, Glauber; Zhang, Yue; Artaxo, Paulo; Bertram, Allan K.; Manzi, A.; Rizzo, L. V.; Souza, Rodrigo A.; Zaveri, Rahul A.; Martin, Scot T.

    2016-01-01

    Particulate matter (PM) occurs in the Earth’s atmosphere both in liquid and non-liquid forms. The physical state affects the available physical and chemical mechanisms of growth and reactivity, ultimately affecting the number, size, and composition of the atmospheric particle population. Herein, the physical state, including the response to relative humidity (RH), was investigated on-line and in real time for PM (< 1 μm) over the tropical rain forest of central Amazonia during both the wet and dry seasons of 2013. The results show that the PM was liquid for RH > 80% across 296 to 300 K. These results, in conjunction with the distributions of RH and temperature in Amazonia, imply that near-surface submicron PM in Amazonia is liquid most of the time. The observations are consistent with laboratory experiments showing that PM produced by isoprene photo-oxidation is liquid across these meteorological conditions. The findings have implications for the mechanisms of new particle production in Amazonia, the growth of submicron particles and hence dynamics of the cloud life cycle, and the sensitivity of these processes to anthropogenic activities. An approach for inclusion of particle physical state in chemical transport models is presented.

  9. LMFBR fuel-design environment for endurance testing, primarily of oxide fuel elements with local faults

    International Nuclear Information System (INIS)

    Warinner, D.K.

    1980-01-01

    The US Department of Energy LMFBR Lines-of-Assurance are briefly stated and local faults are given perspective with an historical review and definition to help define the constraints of LMFBR fuel-element designs. Local-fault-propagation (fuel-element failure-propagation and blockage propagation) perceptions are reviewed. Fuel pin designs and major LMFBR parameters affecting pin performance are summarized. The interpretation of failed-fuel data is aided by a discussion of the effects of nonprototypicalities. The fuel-pin endurance expected in the US, USSR, France, UK, Japan, and West Germany is outlined. Finally, fuel-failure detection and location by delayed-neutron and gaseous-fission-product monitors are briefly discussed to better realize the operational limits

  10. Is there a role of abdominal drainage in primarily repaired perforated peptic ulcers?

    OpenAIRE

    Musharraf Husain; Shahla Haleem; Arif Akhtar; Maulana M. Ansari; Ajay Kumar

    2012-01-01

    Objective: To compare the survival and post-op complications following primary closure of perforated peptic ulcer by omental patch technique in 4 groups of patients as follows: two-drain group, one-drain subhepatic group, one-drain pelvic group and no-drain group. Methods: This is a prospective case-controlled clinical study performed in the Jawaharlal Nehru Medical College Hospital, Aligarh Muslim University, Aligarh, India. A total of 114 patients with perforated peptic ulcer who underwent ...

  11. Copper, Zinc Superoxide Dismutase is Primarily a Cytosolic Protein in Human Cells

    Science.gov (United States)

    Crapo, James D.; Oury, Tim; Rabouille, Catherine; Slot, Jan W.; Chang, Ling-Yi

    1992-11-01

    The intracellular localization of human copper, zinc superoxide dismutase (Cu,Zn-SOD; superoxide:superoxide oxidoreductase, EC 1.15.1.1) was evaluated by using EM immunocytochemistry and both isolated human cell lines and human tissues. Eight monoclonal antibodies raised against either native or recombinant human Cu,Zn-SOD and two polyclonal antibodies raised against either native or recombinant human Cu,Zn-SOD were used. Fixation with 2% paraformaldehyde/0.2% glutaraldehyde was found necessary to preserve normal distribution of the protein. Monoclonal antibodies were less effective than polyclonal antibodies in recognizing the antigen after adequate fixation of tissue. Cu,Zn-SOD was found widely distributed in the cell cytosol and in the cell nucleus, consistent with it being a soluble cytosolic protein. Mitochondria and secretory compartments did not label for this protein. In human cells, peroxisomes showed a labeling density slightly less than that of cytoplasm.

  12. Systemic resilience model

    International Nuclear Information System (INIS)

    Lundberg, Jonas; Johansson, Björn JE

    2015-01-01

    It has been realized that resilience as a concept involves several contradictory definitions, both for instance resilience as agile adjustment and as robust resistance to situations. Our analysis of resilience concepts and models suggest that beyond simplistic definitions, it is possible to draw up a systemic resilience model (SyRes) that maintains these opposing characteristics without contradiction. We outline six functions in a systemic model, drawing primarily on resilience engineering, and disaster response: anticipation, monitoring, response, recovery, learning, and self-monitoring. The model consists of four areas: Event-based constraints, Functional Dependencies, Adaptive Capacity and Strategy. The paper describes dependencies between constraints, functions and strategies. We argue that models such as SyRes should be useful both for envisioning new resilience methods and metrics, as well as for engineering and evaluating resilient systems. - Highlights: • The SyRes model resolves contradictions between previous resilience definitions. • SyRes is a core model for envisioning and evaluating resilience metrics and models. • SyRes describes six functions in a systemic model. • They are anticipation, monitoring, response, recovery, learning, self-monitoring. • The model describes dependencies between constraints, functions and strategies

  13. Computerized provider order entry systems.

    Science.gov (United States)

    2001-01-01

    Computerized provider order entry (CPOE) systems are designed to replace a hospital's paper-based ordering system. They allow users to electronically write the full range of orders, maintain an online medication administration record, and review changes made to an order by successive personnel. They also offer safety alerts that are triggered when an unsafe order (such as for a duplicate drug therapy) is entered, as well as clinical decision support to guide caregivers to less expensive alternatives or to choices that better fit established hospital protocols. CPOE systems can, when correctly configured, markedly increase efficiency and improve patient safety and patient care. However, facilities need to recognize that currently available CPOE systems require a tremendous amount of time and effort to be spent in customization before their safety and clinical support features can be effectively implemented. What's more, even after they've been customized, the systems may still allow certain unsafe orders to be entered. Thus, CPOE systems are not currently a quick or easy remedy for medical errors. ECRI's Evaluation of CPOE systems--conducted in collaboration with the Institute for Safe Medication Practices (ISMP)--discusses these and other related issues. It also examines and compares CPOE systems from three suppliers: Eclipsys Corp., IDX Systems Corp., and Siemens Medical Solutions Health Services Corp. Our testing focuses primarily on the systems' interfacing capabilities, patient safeguards, and ease of use.

  14. Technical specifications manual for the MARK-1 pulsed ionizing radiation detection system

    International Nuclear Information System (INIS)

    Lawrence, R.S.; Harker, Y.D.; Jones, J.L.; Hoggan, J.M.

    1993-03-01

    The MARK-1 detection system was developed by the Idaho National Engineering Laboratory for the US Department of Energy Office of Arms Control and Nonproliferation. The completely portable system was designed for the detection and analysis of intense photon emissions from pulsed ionizing radiation sources. This manual presents the technical design specifications for the MARK-1 detection system and was written primarily to assist the support or service technician in the service, calibration, and repair of the system. The manual presents the general detection system theory, the MARK-1 component design specifications, the acquisition and control software, the data processing sequence, and the system calibration procedure. A second manual entitled: Volume 2: Operations Manual for the MARK-1 Pulsed Ionizing Radiation Detection System (USDOE Report WINCO-1108, September 1992) provides a general operational description of the MARK-1 detection system. The Operations Manual was written primarily to assist the field operator in system operations and analysis of the data

  15. Technical specifications manual for the MARK-1 pulsed ionizing radiation detection system. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence, R.S.; Harker, Y.D.; Jones, J.L.; Hoggan, J.M.

    1993-03-01

    The MARK-1 detection system was developed by the Idaho National Engineering Laboratory for the US Department of Energy Office of Arms Control and Nonproliferation. The completely portable system was designed for the detection and analysis of intense photon emissions from pulsed ionizing radiation sources. This manual presents the technical design specifications for the MARK-1 detection system and was written primarily to assist the support or service technician in the service, calibration, and repair of the system. The manual presents the general detection system theory, the MARK-1 component design specifications, the acquisition and control software, the data processing sequence, and the system calibration procedure. A second manual entitled: Volume 2: Operations Manual for the MARK-1 Pulsed Ionizing Radiation Detection System (USDOE Report WINCO-1108, September 1992) provides a general operational description of the MARK-1 detection system. The Operations Manual was written primarily to assist the field operator in system operations and analysis of the data.

  16. Short Rotation Crops in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Wright, L L

    1998-06-04

    The report is based primarily on the results of survey questions sent to approximately 60 woody and 20 herbaceous crop researchers in the United States and on information from the U.S. Department of Energy's Bioenergy Feedstock Development Program. Responses were received from 13 individuals involved in woody crops research or industrial commercialization (with 5 of the responses coming from industry). Responses were received from 11 individuals involved in herbaceous crop research. Opinions on market incentives, technical and non-technical barriers, and highest priority research and development areas are summarized in the text. Details on research activities of the survey responders are provided as appendices to the paper. Woody crops grown as single-stem systems (primarily Populus and Eucalyptus species) are perceived to have strong pulp fiber and oriented strand board markets, and the survey responders anticipated that energy will comprise 25% or less of the utilization of single-stem short-rotation woody crops between now and 2010. The only exception was a response from California where a substantial biomass energy market does currently exist. Willows (Salix species) are only being developed for energy and only in one part of the United States at present. Responses from herbaceous crop researchers suggested frustration that markets (including biomass energy markets) do not currently exist for the crop, and it was the perception of many that federal incentives will be needed to create such markets. In all crops, responses indicate that a wide variety of research and development activities are needed to enhance the yields and profitability of the crops. Ongoing research activities funded by the U.S. Department of Energy's Bioenergy Feedstock Development Program are described in an appendix to the paper.

  17. Pneumatic transport systems for TRIGA reactors

    International Nuclear Information System (INIS)

    Bolton, John A.

    1970-01-01

    Main parameters and advantages of pneumatically operated systems, primarily those operated by gas pressure are discussed. The special irradiation ends for the TRIGA reactor are described. To give some idea of the complexity of some modern systems, the author presents the large system currently operating at the National Bureau of Standards in Washington. In this system, 13 stations are located throughout the radiochemistry laboratories and three irradiation ends are located in the reactor, which is a 14-megawatt unit. The system incorporates practically every fail-safe device possible, including ball valves located on all capsule lines entering the reactor area, designed to close automatically in the event of a reactor scram, and at that time capsules within the reactor would be diverted by means of switches located on the inside of the reactor wall. The whole system is under final control of a permission control panel located in the reactor control room. Many other safety accessories of the system are described

  18. Thermo Active Building Systems – Using Building Mass To Heat and Cool

    DEFF Research Database (Denmark)

    Olesen, Bjarne W.

    2014-01-01

    , Austria, Netherlands, etc.), this type of system has been installed in a significant number of new office buildings since the late 1990s. The trend is spreading to other parts of the world (the rest of Europe, North America and Asia). Thermo active building systems (TABS) are primarily used for cooling...

  19. A Statically Scheduled Time-Division-Multiplexed Network-on-Chip for Real-Time Systems

    DEFF Research Database (Denmark)

    Schoeberl, Martin; Brandner, Florian; Sparsø, Jens

    2012-01-01

    This paper explores the design of a circuit-switched network-on-chip (NoC) based on time-division-multiplexing (TDM) for use in hard real-time systems. Previous work has primarily considered application-specific systems. The work presented here targets general-purpose hardware platforms. We...

  20. The education revolution on horseback I : The relation between Napoleon Bonaparte and education system characteristics

    NARCIS (Netherlands)

    Korthals, R.A.

    2016-01-01

    Much research has been done into the emergence of mass education systems, primarily by studying the social origin of the education system, the introduction of compulsory schooling laws, or the expansion of enrolment rates. However, little is known about the origin of the characteristics of these

  1. The education revolution on horseback I: The relation between Napoleon Bonaparte and education system characteristics

    NARCIS (Netherlands)

    Korthals, Roxanne

    2016-01-01

    Much research has been done into the emergence of mass education systems, primarily by studying the social origin of the education system, the introduction of compulsory schooling laws, or the expansion of enrolment rates. However, little is known about the origin of the characteristics of these

  2. Low-Cost Undergraduate Control Systems Experiments Using Microcontroller-Based Control of a DC Motor

    Science.gov (United States)

    Gunasekaran, M.; Potluri, R.

    2012-01-01

    This paper presents low-cost experiments for a control systems laboratory module that is worth one and a third credits. The experiments are organized around the microcontroller-based control of a permanent magnet dc motor. The experimental setups were built in-house. Except for the operating system, the software used is primarily freeware or free…

  3. System Budgets

    DEFF Research Database (Denmark)

    Jeppesen, Palle

    1996-01-01

    The lecture note is aimed at introducing system budgets for optical communication systems. It treats optical fiber communication systems (six generations), system design, bandwidth effects, other system impairments and optical amplifiers.......The lecture note is aimed at introducing system budgets for optical communication systems. It treats optical fiber communication systems (six generations), system design, bandwidth effects, other system impairments and optical amplifiers....

  4. Selected systems engineering process deficiencies and their consequences

    Science.gov (United States)

    Thomas, L. Dale

    2007-06-01

    The systems engineering process is well established and well understood. While this statement could be argued in the light of the many systems engineering guidelines and that have been developed, comparative review of these respective descriptions reveal that they differ primarily in the number of discrete steps or other nuances, and are at their core essentially common. Likewise, the systems engineering textbooks differ primarily in the context for application of systems engineering or in the utilization of evolved tools and techniques, not in the basic method. Thus, failures in systems engineering cannot credibly be attributed to implementation of the wrong systems engineering process among alternatives. However, numerous system failures can be attributed to deficient implementation of the systems engineering process. What may clearly be perceived as a systems engineering deficiency in retrospect can appear to be a well considered system engineering efficiency in real time—an efficiency taken to reduce cost or meet a schedule, or more often both. Typically these efficiencies are grounded on apparently solid rationale, such as reuse of heritage hardware or software. Over time, unintended consequences of a systems engineering process deficiency may begin to be realized, and unfortunately often the consequence is systems failure. This paper describes several actual cases of system failures that resulted from deficiencies in their systems engineering process implementation, including the Ariane 5 and the Hubble Space Telescope.

  5. Group Discovery in a CollaborativeTagging System

    OpenAIRE

    Chen, Zijian

    2007-01-01

    Tagging refers to the process of adding metadata to describe things by usingone or several words. Collaborative Tagging systems, which allow different webusers to tag web content like weblogs, pictures, and bookmarks and so on, haverecently gained great popularity on internet. There are already a greatvariety of debates on internet of the advantages and disadvantages ofcollaborative tagging systems from the aspect of information organizing. Inthis paper, we primarily focus on a collaborative ...

  6. Information system quality in work-life balance

    OpenAIRE

    Sharmini Gopinathan; Murali Raman

    2016-01-01

    This paper aims to look for the role information systems quality may play in work-life balance among Malaysian ICT employees. The results of this study will be useful in the development of new tools and technologies that are focused on ISQ dimensions primarily information system quality which can be helpful to devise suggestions to the ICT sector on matters pertaining to sustainable development/policy formulation with reference to achieving a good work-life balance. A total of 79 respondents’...

  7. Financing and disseminating small energy systems in rural areas

    International Nuclear Information System (INIS)

    Waddle, D.B.; Perlack, R.D.

    1992-01-01

    The viability of small energy systems, primarily photovoltaic systems, is discussed as an alternative for rural electrification via traditional grid extension. A dissemination model that incorporates financing to allow access to a much larger population of users and technology support (e.g. training for sales and service and small business development) is described. The experience of two successful programs is presented to illustrate the keys to effective program development and implementation. (author)

  8. Radiation therapy of tumours of the central nervous system

    International Nuclear Information System (INIS)

    Skolyszewski, J.

    1980-01-01

    The aim of this work is to present the principles of radiation therapy of tumours of the central nervous system, according to the experience of the Institute of Oncology in Krakow. The text was designed primarily for the radiotherapists involved in the treatment of tumours of the central nervous system, and may be used as an auxiliary textbook for those preparing for the examination in radiotherapy. (author)

  9. Syllabus for Weizmann Course: Earth System Science 101

    Science.gov (United States)

    Wiscombe, Warren J.

    2011-01-01

    This course aims for an understanding of Earth System Science and the interconnection of its various "spheres" (atmosphere, hydrosphere, etc.) by adopting the view that "the microcosm mirrors the macrocosm". We shall study a small set of microcosims, each residing primarily in one sphere, but substantially involving at least one other sphere, in order to illustrate the kinds of coupling that can occur and gain a greater appreciation of the complexity of even the smallest Earth System Science phenomenon.

  10. Development of operator requested control system applications: Experience with the SLC control system at SLAC

    International Nuclear Information System (INIS)

    Stanek, M.

    1995-01-01

    The SLC Control system at SLAC has evolved into a powerful tool for operation of the accelerator and for troubleshooting the unique problems encountered in extracting maximum performance from the SLC. The evolution has included the development of many custom applications and user interface features generated from accelerator operator and accelerator physicist requests. These applications are written and maintained primarily by the Controls Software Engineering group, and not by the users themselves. The process of developing and supporting user requested control systems applications at SLAC is described, including the effects of organizational structure, formal and informal procedures, and control system architecture

  11. The Soviet RBMK-1000 containment system

    International Nuclear Information System (INIS)

    Joosten, J.K.

    1988-01-01

    Following the accident in April, 1986, considerable attention was focused on the failure of the containment at the Chernobyl RBMK-1000 nuclear power plant. Conflicting statements arose regarding the nature of the plant's containment system primarily because of terminology differences, translation difficulties and lack of reliable information. This article, based on reports and briefings by the Soviet delegation, during the post-accident review meetings in Vienna and prior publications is intended to clarify perceptions of the Soviet RMBK-1000 nuclear power plant containment system design, and its relevance to containment management concepts. (author)

  12. Remote viewing system development in BNFL

    International Nuclear Information System (INIS)

    Case, D.R.; Garlick, D.R.; Crawford, G.; Montgomerie, J.

    1996-01-01

    The application of imaging systems to BNFL's plants is primarily provided by the Company's Engineering Group. Many systems have been developed for active service and several new developments are currently in an advanced stage of implementation. BNFL has acquired extensive experience of remote viewing from a series of projects undertaken for the Sellafield site in West Cumbria. Applications vary in size and complexity, from simple identification of bar-codes to more complex schemes for remotely storing UO 3 drums. Some are high speed and highly repetitive, whereas others are low speed but require high precision. In this paper the authors outline a selection of current applications. (UK)

  13. An introduction to the FASTBUS system

    International Nuclear Information System (INIS)

    Rimmer, E.M.

    1980-11-01

    FASTBUS is a standard bus system being developed, primarily, for high-speed data acquisition and processing in the next generation of large-scale physics experiments. It is built up from backplane segments housed in crates, linked together by cable segments for inter-crate communication. Each segment supports multiprocessors, and independent segment operation permits a high degree of parallelism. Handshaked bus protocols, uniform system-wide, ensure reliability and both high- and low-speed devices can be accommodated. A synchronous mode provides for data block transfers at maximum speed. The fundamental structure of FASTBUS and details of its basic operations are presented. (author)

  14. Remote viewing system development in BNFL

    International Nuclear Information System (INIS)

    Case, D.R.; Garlick, D.R.; Crawford, G.; Montgomerie, J.

    1996-01-01

    The application of imaging systems to BNFL's plants is primarily provided by the Company's Engineering Group. Many systems have been developed for active service and several new developments are currently in an advanced stage of implementation. BNFL has acquired extensive experience of remote viewing from a series of projects undertaken for the Sellafield site in West Cumbria. Applications vary in size and complexity, from simple identification of bar-codes to more complex schemes for remotely storing UO 3 drums. Some are high speed and highly repetitive, whereas others are low speed but require high precision. In this paper the authors shall outline a selection of current applications. (Author)

  15. Communication for command and control systems

    CERN Document Server

    Morris, D J

    1983-01-01

    Communication for Command and Control Systems provides a thorough exposition of the basic theoretical and practical features involved in the design of communication networks for command and control systems. This book focuses primarily on the practical side of computer-controlled communication. This text concentrates on the communication sides of the subject by surveying the means of transferring data between the various processing points and by appraising their potential advantages and possible defects in implementation. In this respect, this book should prove useful for the practicing enginee

  16. Monitoring aquatic environments with autonomous systems

    DEFF Research Database (Denmark)

    Christensen, Jesper Philip Aagaard

    High frequency measurements from autonomous sensors have become a widely used tool among aquatic scientists. This report focus primarily on the use of ecosystem metabolism based on high frequency oxygen measurements and relates the calculations to spatial variation, biomass of the primary producers...... and in shallow systems the macrophytes can completely dominate primary production. This was despite the fact that the plants in the studied system were light-saturated most of the light hours and occasionally carbon limited. It was also shown that the GPP and the total phytoplankton biomass in a nutrient...

  17. Interactive and automated systems for nuclear track measurements with applications to fast neutron dosimetry

    International Nuclear Information System (INIS)

    Roberts, J.H.; Gold, R.; McNeece, J.P.; Preston, C.C.; Ruddy, F.H.

    1983-12-01

    Interactive and automatic track measuring systems have been developed primarily for fast neutron dosimetry in and around reactors. The interactive system is used for proton recoil measurements in nuclear research emulsions and the automatic systems for counting fission fragment tracks in Muscovite mica. The status of these systems, along with illustrative applications, are presented, particularly with regard to their relationship to neutron personnel dosimetry. 16 references, 12 figures

  18. Functions and requirements for the light duty utility arm integrated system

    International Nuclear Information System (INIS)

    Kiebel, G.R.

    1996-01-01

    The Light Duty Utility Arm (LDUA) Integrated System is a mobile robotic system designed to remotely deploy and operate a variety of tools in uninhabitable underground radiological and hazardous waste storage tanks. The system primarily provides a means to inspect, survey, monitor, map and/or obtain specific waste and waste tank data in support of the Tank Waste Remediation System (TWRS) mission at Hanford and remediation programs at other U.S. Department of Energy (DOE) sites

  19. Functions and requirements for the Light-Duty Utility Arm Integrated System. Revision 1

    International Nuclear Information System (INIS)

    Kiebel, G.R.

    1996-01-01

    The Light Duty Utility Arm (LDUA) Integrated System is a mobile robotic system designed to remotely deploy and operate a variety of tools in uninhabitable underground radiological and hazardous waste storage tanks. The system primarily provides a means to inspect, survey, monitor, map and/or obtain specific waste and waste tank data in support of the Tank Waste Remediation System (TWRS) mission at Hanford and remediation programs at other U.S. Department of Energy (DOE) sites

  20. Secure stand alone positive personnel identity verification system (SSA-PPIV)

    International Nuclear Information System (INIS)

    Merillat, P.D.

    1979-03-01

    The properties of a secure stand-alone positive personnel identity verification system are detailed. The system is designed to operate without the aid of a central computing facility and the verification function is performed in the absence of security personnel. Security is primarily achieved by means of data encryption on a magnetic stripe badge. Several operational configurations are discussed. Advantages and disadvantages of this system compared to a central computer driven system are detailed

  1. Modifications to Replacement Costs System

    International Nuclear Information System (INIS)

    Godec, M.

    1989-01-01

    The purpose of this memorandum is to document the improvements and modifications made to the Replacement Costs of Crude Oil (REPCO) Supply Analysis System. While some of this work was performed under our previous support contract to DOE/ASFE, we are presenting all modifications and improvements are presented here for completeness. The memo primarily documents revisions made to the Lower-48 Onshore Model. Revisions and modifications made to other components and models in the REPCO system which are documented elsewhere are only highlighted in this memo. Generally, the modifications made to the Lower-48 Onshore Model reflect changes that have occurred in domestic drilling, oil field costs, and reserves since 1982, the date of the most recent available data used for the original Replacement Costs report, published in 1985

  2. FIRE PROTECTION SYSTEMS AND TECHNOLOGIES

    Directory of Open Access Journals (Sweden)

    Aristov Denis Ivanovich

    2016-03-01

    Full Text Available The All-Russian Congress “Fire Stop Moscow” was de-voted to the analysis of the four segments of the industry of fire protection systems and technologies: the design of fire protec-tion systems, the latest developments and technologies of active and passive fire protection of buildings, the state and the devel-opment of the legal framework, the practice of fire protection of buildings and structures. The forum brought together the repre-sentatives of the industry of fire protection systems, scientists, leading experts, specialists in fire protection and representatives of construction companies from different regions of Russia. In parallel with the Congress Industrial Exhibition of fire protection systems, materials and technology was held, where manufacturers presented their products. The urgency of the “Fire Stop Moscow” Congress in 2015 organized by the Congress Bureau ODF Events lies primarily in the fact that it considered the full range of issues related to the fire protection of building and construction projects; studied the state of the regulatory framework for fire safety and efficiency of public services, research centers, private companies and busi-nesses in the area of fire safety. The main practical significance of the event which was widely covered in the media space, was the opportunity to share the views and information between management, science, and practice of business on implementing fire protection systems in the conditions of modern economic relations and market realities. : congress, fire protection, systems, technologies, fire protection systems, exhibition

  3. Ventilation systems

    International Nuclear Information System (INIS)

    Gossler

    1980-01-01

    The present paper deals with - controlled area ventilation systems - ventilation systems for switchgear-building and control-room - other ventilation systems for safety equipments - service systems for ventilation systems. (orig./RW)

  4. The cement solidification systems at LANL

    International Nuclear Information System (INIS)

    Veazey, G.W.

    1990-01-01

    There are two major cement solidification systems at Los Alamos National Laboratory. Both are focused primarily around treating waste from the evaporator at TA-55, the Plutonium Processing Facility. The evaporator receives the liquid waste stream from TA-55's nitric acid-based, aqueous-processing operations and concentrates the majority of the radionuclides in the evaporator bottoms solution. This is sent to the TA-55 cementation system. The evaporator distillate is sent to the TA-50 facility, where the radionuclides are precipitated and then cemented. Both systems treat TRU-level waste, and so are operated according to the criteria for WIPP-destined waste, but they differ in both cement type and mixing method. The TA-55 systems uses Envirostone, a gypsum-based cement and in-drum prop mixing; the TA-50 systems uses Portland cement and drum tumbling for mixing

  5. Chinese very small aperture terminal system for ministries

    Science.gov (United States)

    Dan, Sen

    The objective and technologic approach of the Chinese very small aperture terminal (VSAT) system of data communications is described in this paper. The system is primarily designed for the management business of many governmental ministries and administrations. It consists of a centralized processing and switching facility and a number of groups of remote terminals. The network is constructed in a star configuration because of simplicity and the inherent nature of the management business. Either Intelsat of Chinese domestic communications satellite can be used for the space segment. The system performance has been verified by field trials. Some results of system analysis can be used for traffic design.

  6. Type I interferon signature in systemic lupus erythematosus.

    Science.gov (United States)

    Bezalel, Shira; Guri, Keren Mahlab; Elbirt, Daniel; Asher, Ilan; Sthoeger, Zev Moshe

    2014-04-01

    Type I interferons (IFN) are primarily regarded as an inhibitor of viral replication. However, type I IFN, mainly IFNalpha, plays a major role in activation of both the innate and adaptive immune systems. Systemic lupus erythematosus (SLE) is a chronic, multi-systemic, inflammatory autoimmune disease with undefined etiology. SLE is characterized by dysregulation of both the innate and the adaptive immune systems. An increased expression of type I IFN-regulated genes, termed IFN signature, has been reported in patients with SLE. We review here the role of IFNalpha in the pathogenesis and course of SLE and the possible role of IFNalpha inhibition as a novel treatment for lupus patients.

  7. Expert systems for plant operations training and assistance

    International Nuclear Information System (INIS)

    Pack, R.W.; Lazar, P.M.; Schmidt, R.V.; Gaddy, C.D.

    1988-01-01

    The project described in this paper explored the use of expert systems for plant operations training and assistance. Three computer technologies were reviewed: computer-aided instruction, expert systems, and expert training systems (ETS). The technology of CAI has been developed since the early 1960s, and a wide range of applications are available commercially today. Expert systems have been developed primarily as job performance aids, and the number of commercial applications is increasing. A fully developed ETS has models of the trainer and trainee, in addition to a knowledge base

  8. On Optimal Feedback Control for Stationary Linear Systems

    International Nuclear Information System (INIS)

    Russell, David L.

    2010-01-01

    We study linear-quadratic optimal control problems for finite dimensional stationary linear systems AX+BU=Z with output Y=CX+DU from the viewpoint of linear feedback solution. We interpret solutions in relation to system robustness with respect to disturbances Z and relate them to nonlinear matrix equations of Riccati type and eigenvalue-eigenvector problems for the corresponding Hamiltonian system. Examples are included along with an indication of extensions to continuous, i.e., infinite dimensional, systems, primarily of elliptic type.

  9. Using Statechart Assertion for the Formal Validation and Verification of a Real-Time Software System: A Case Study

    Science.gov (United States)

    2011-03-01

    could be an entry point into a repeated task (or thread). The following example uses binary semaphores . The VxWorks operating system utilizes binary... semaphores via system calls: SemTake and SemGive. These semaphores are used primarily for mutual exclusion to protect resources from being accessed

  10. System Interface for an Integrated Intelligent Safety System (ISS for Vehicle Applications

    Directory of Open Access Journals (Sweden)

    Mahammad A. Hannan

    2010-01-01

    Full Text Available This paper deals with the interface-relevant activity of a vehicle integrated intelligent safety system (ISS that includes an airbag deployment decision system (ADDS and a tire pressure monitoring system (TPMS. A program is developed in LabWindows/CVI, using C for prototype implementation. The prototype is primarily concerned with the interconnection between hardware objects such as a load cell, web camera, accelerometer, TPM tire module and receiver module, DAQ card, CPU card and a touch screen. Several safety subsystems, including image processing, weight sensing and crash detection systems, are integrated, and their outputs are combined to yield intelligent decisions regarding airbag deployment. The integrated safety system also monitors tire pressure and temperature. Testing and experimentation with this ISS suggests that the system is unique, robust, intelligent, and appropriate for in-vehicle applications.

  11. Systems Engineering as a tool; Verktoeyet Systems Engineering : struktur fra start til maal

    Energy Technology Data Exchange (ETDEWEB)

    Carlsen, Randi

    2002-07-01

    Systems engineering integrates all types of specialists and disciplines into teams that try to create a structured development process from concept via production to operation. The idea is that by using systems engineering, projects can be completed efficiently and successfully. It is important that the individual participant in a project understands that he or she works within a system and that there is a need for skill, comprehensiveness and communication. Systems engineering comprises system design, computer aided design, cybernetics and mecatronics. The article describes the use of systems engineering in a student project in which a heat pump will be used to utilize the energy potential of ground water primarily to heat the visitors' area in a mine museum in Kongsberg, Norway.

  12. Satellite power system concept development and evaluation program system definition technical assessment report

    Energy Technology Data Exchange (ETDEWEB)

    1980-12-01

    The results of the system definition studies conducted by NASA as a part of the Department of Energy/National Aeronautics and Space Administration SPS Concept Development and Evaluation Program are summarized. The purpose of the system definition efforts was to identify and define candidate SPS concepts and to evaluate the concepts in terms of technical and cost factors. Although the system definition efforts consisted primarily of evaluation and assessment of alternative technical approaches, a reference system was also defined to facilitate economic, environmental, and societal assessments by the Department of Energy. This reference system was designed to deliver 5 GW of electrical power to the utility grid. Topics covered include system definition; energy conversion and power management; power transmission and reception; structures, controls, and materials; construction and operations; and space transportation.

  13. Cognitariat in the management system of higher education of Germany as a sourse of social rationality

    OpenAIRE

    Швець, Дмитро Євгенович

    2014-01-01

    To achieve effective management of the higher education system, as well as of any sphere of public administration, it is necessary to maintain the administrative class with corresponding cognitive culture. In Ukraine, there is now a problem connected with the creation of an effective mechanism of managers selection in higher education, as the current system of selection has been based primarily on the formal and legal basis. German experience for the Ukrainian system of universities is quite ...

  14. Online, real-time corrosion monitoring in district heating systems

    DEFF Research Database (Denmark)

    Hilbert, Lisbeth Rischel; Thorarinsdottir, R.I.

    2005-01-01

    The corrosion control in district heating systems is today performed primarily with control of the water quality. The corrosion rate is kept low by assuring low dissolved oxygen concentration, high pH and low conductivity. Corrosion failures can occur, e.g. as a result of unknown oxygen ingress, ......, precipitation of deposits or crevices. The authors describe methods used for on-line monitoring of corrosion, cover the complications and the main results of a Nordic project.......The corrosion control in district heating systems is today performed primarily with control of the water quality. The corrosion rate is kept low by assuring low dissolved oxygen concentration, high pH and low conductivity. Corrosion failures can occur, e.g. as a result of unknown oxygen ingress...

  15. On-line Corrosion Monitoring in District Heating Systems

    DEFF Research Database (Denmark)

    Richter, Sonja; Thorarinsdottir, R.I.; Hilbert, Lisbeth Rischel

    2005-01-01

    The corrosion control in district heating systems is today performed primarily with control of the water quality. The corrosion rate is kept low by assuring low dissolved oxygen concentration, high pH and low conductivity. Corrosion failures can occur, e.g. as a result of unknown oxygen ingress, ......, precipitation of deposits or crevices. The authors describe methods used for on-line monitoring of corrosion, cover the complications and the main results of a Nordic project.......The corrosion control in district heating systems is today performed primarily with control of the water quality. The corrosion rate is kept low by assuring low dissolved oxygen concentration, high pH and low conductivity. Corrosion failures can occur, e.g. as a result of unknown oxygen ingress...

  16. Embedded Systems

    Indian Academy of Sciences (India)

    Embedded system, micro-con- troller ... Embedded systems differ from general purpose computers in many ... Low cost: As embedded systems are extensively used in con- .... operating systems for the desktop computers where scheduling.

  17. Software engineering practices for control system reliability

    International Nuclear Information System (INIS)

    S. K. Schaffner; K. S White

    1999-01-01

    This paper will discuss software engineering practices used to improve Control System reliability. The authors begin with a brief discussion of the Software Engineering Institute's Capability Maturity Model (CMM) which is a framework for evaluating and improving key practices used to enhance software development and maintenance capabilities. The software engineering processes developed and used by the Controls Group at the Thomas Jefferson National Accelerator Facility (Jefferson Lab), using the Experimental Physics and Industrial Control System (EPICS) for accelerator control, are described. Examples are given of how their procedures have been used to minimized control system downtime and improve reliability. While their examples are primarily drawn from their experience with EPICS, these practices are equally applicable to any control system. Specific issues addressed include resource allocation, developing reliable software lifecycle processes and risk management

  18. Walking beam pumping unit system efficiency measurements

    International Nuclear Information System (INIS)

    Kilgore, J.J.; Tripp, H.A.; Hunt, C.L. Jr.

    1991-01-01

    The cost of electricity used by walking beam pumping units is a major expense in producing crude oil. However, only very limited information is available on the efficiency of beam pumping systems and less is known about the efficiency of the various components of the pumping units. This paper presents and discusses measurements that have been made on wells at several Shell locations and on a specially designed walking beam pump test stand at Lufkin Industries. These measurements were made in order to determine the overall system efficiency and efficiency of individual components. The results of this work show that the overall beam pumping system efficiency is normally between 48 and 58 percent. This is primarily dependent on the motor size, motor type, gearbox size, system's age, production, pump size, tubing size, and rod sizes

  19. Managing organizational culture within a management system

    International Nuclear Information System (INIS)

    Comeau, L.; Watts, G.

    2009-01-01

    The Point Lepreau Generating Station (PLGS) is currently undergoing a major refurbishment of its nuclear reactor. At the same time, a small team is designing the organization that will operate the plant after refurbishment. This paper offers a high level overview of the Post-Refurbishment Organization (PRO) project and will focus primarily on the approach used to address organizational culture and human system dynamics. We will describe how various tools, used to assess organization culture, team performance, and individual self-understanding, are used collectively to place the right person in the right position. We will explain how the career system, Pathfinder, is used to integrate these tools to support a comprehensive model for organization design and development. Finally, we demonstrate how the management of organizational cultural and human system dynamics are integrated into the PLGS Integrated Management System. (author)

  20. Degradation mechanisms of small scale piping systems

    International Nuclear Information System (INIS)

    Bartonicek, J.; Koenig, G.; Blind, D.

    1996-01-01

    Operational experience shows that many degradation mechanisms can have an effect on small-scale piping systems. We can see from the analyses carried out that the degradation which has occurred is primarily linked with the fact that these piping systems were classified as being of low safety relevance. This is mainly due to such components being classified into low safety relevance category at the design stage, as well as to the low level of operational monitoring. Since in spite of the variety of designs and operational modes the degradation mechanisms detected may be attributed to the piping systems, we can make decisive statements on how to avoid such degradation mechanisms. Even small-scale piping systems may achieve guaranteed integrity in such cases by taking the appropriate action. (orig.) [de

  1. A fuzzy expert system based on relations

    International Nuclear Information System (INIS)

    Hall, L.O.; Kandel, A.

    1986-01-01

    The Fuzzy Expert System (FESS) is an expert system which makes use of the theory of fuzzy relations to perform inference. Relations are very general and can be used for any application, which only requires different types of relations be implemented and used. The incorporation of fuzzy reasoning techniques enables the expert system to deal with imprecision in a well-founded manner. The knowledge is represented in relational frames. FESS may operate in either a forward chaining or backward chaining manner. It uses primarily implication and factual relations. A unique methodology for combination of evidence has been developed. It makes uses of a blackboard for communication between the various knowledge sources which may operate in parallel. The expert system has been designed in such a manner that it may be used for diverse applications

  2. Multispectral system for medical fluorescence imaging

    International Nuclear Information System (INIS)

    Andersson, P.S.; Montan, S.; Svanberg, S.

    1987-01-01

    The principles of a powerful multicolor imaging system for tissue fluorescence diagnostics are discussed. Four individually spectrally filtered images are formed on a matrix detector by means of a split-mirror arrangement. The four images are processed in a computer, pixel by pixel, by means of mathematical operations, leading to an optimized contrast image, which enhances a selected feature. The system is being developed primarily for medical fluorescence imaging, but has wide applications in fluorescence, reflectance, and transmission monitoring related to a wide range of industrial and environmental problems. The system operation is described for the case of linear imaging on a diode array detector. Laser-induced fluorescence is used for cancer tumor and arteriosclerotic plaque demarcation using the contrast enhancement capabilities of this imaging system. Further examples of applications include fluorescing minerals and flames

  3. Energy innovation systems indicator report 2012

    Energy Technology Data Exchange (ETDEWEB)

    Borup, M. [Technical Univ. of Denmark. DTU Management Engineering, Kgs. Lyngby (Denmark); Klitkou, A.; Iversen, E. [Nordic Institute for Studies in Innovation, Research and Education, Oslo (Norway)

    2012-12-15

    Knowledge about the innovation systems with respect to new energy solutions and technologies is of central importance for understanding the dynamics of change in the energy sector and assessment of opportunities for moving towards more climate-friendly and sustainable energy systems and for socio-economic development in the field, creation of new businesses, work places, etc.. This is the topic that in general is addressed in the research activities of the ''EIS - Strategic research alliance for Energy Innovation Systems and their dynamics - Denmark in global competition''. As part of this, the present report gives an overview of the available indicators of energy innovation systems and points out some of the limitations and potentials there currently are in this connection. Focus is on Denmark. Figures for other countries, primarily Nordic or European, are in some cases showed as well, offering a comparative perspective. (Author)

  4. Thermal systems; Systemes thermiques

    Energy Technology Data Exchange (ETDEWEB)

    Lalot, S. [Valenciennes Univ. et du Hainaut Cambresis, LME, 59 (France); Lecoeuche, S. [Ecole des Mines de Douai, Dept. GIP, 59 - Douai (France)]|[Lille Univ. des Sciences et Technologies, 59 - Villeneuve d' Ascq (France); Ahmad, M.; Sallee, H.; Quenard, D. [CSTB, 38 - Saint Martin d' Heres (France); Bontemps, A. [Universite Joseph Fourier, LEGI/GRETh, 38 - Grenoble (France); Gascoin, N.; Gillard, P.; Bernard, S. [Laboratoire d' Energetique, Explosion, Structure, 18 - Bourges (France); Gascoin, N.; Toure, Y. [Laboratoire Vision et Robotique, 18 - Bourges (France); Daniau, E.; Bouchez, M. [MBDA, 18 - Bourges (France); Dobrovicescu, A.; Stanciu, D. [Bucarest Univ. Polytechnique, Faculte de Genie Mecanique (Romania); Stoian, M. [Reims Univ. Champagne Ardenne, Faculte des Sciences, UTAP/LTM, 51 (France); Bruch, A.; Fourmigue, J.F.; Colasson, S. [CEA Grenoble, Lab. Greth, 38 (France); Bontemps, A. [Universite Joseph Fourier, LEGI/GRETh, 38 - Grenoble (France); Voicu, I.; Mare, T.; Miriel, J. [Institut National des Sciences Appliquees (INSA), LGCGM, IUT, 35 - Rennes (France); Galanis, N. [Sherbrooke Univ., Genie Mecanique, QC (Canada); Nemer, M.; Clodic, D. [Ecole des Mines de Paris, Centre Energetique et Procedes, 75 (France); Lasbet, Y.; Auvity, B.; Castelain, C.; Peerhossaini, H. [Nantes Univ., Ecole Polytechnique, Lab. de Thermocinetiquede Nantes, UMR-CNRS 6607, 44 (France)

    2005-07-01

    This session about thermal systems gathers 26 articles dealing with: neural model of a compact heat exchanger; experimental study and numerical simulation of the thermal behaviour of test-cells with walls made of a combination of phase change materials and super-insulating materials; hydraulic and thermal modeling of a supercritical fluid with pyrolysis inside a heated channel: pre-dimensioning of an experimental study; energy analysis of the heat recovery devices of a cryogenic system; numerical simulation of the thermo-hydraulic behaviour of a supercritical CO{sub 2} flow inside a vertical tube; mixed convection inside dual-tube exchangers; development of a nodal approach with homogenization for the simulation of the brazing cycle of a heat exchanger; chaotic exchanger for the cooling of low temperature fuel cells; structural optimization of the internal fins of a cylindrical generator; a new experimental approach for the study of the local boiling inside the channels of exchangers with plates and fins; experimental study of the flow regimes of boiling hydrocarbons on a bundle of staggered tubes; energy study of heat recovery exchangers used in Claude-type refrigerating systems; general model of Carnot engine submitted to various operating constraints; the free pistons Stirling cogeneration system; natural gas supplied cogeneration system with polymer membrane fuel cell; influence of the CRN coating on the heat flux inside the tool during the wood unrolling process; transport and mixture of a passive scalar injected inside the wake of a Ahmed body; control of a laser welding-brazing process by infrared thermography; 2D self-adaptative method for contours detection: application to the images of an aniso-thermal jet; exergy and exergy-economical study of an 'Ericsson' engine-based micro-cogeneration system; simplified air-conditioning of telephone switching equipments; parametric study of the 'low-energy' individual dwelling; brief synthesis of

  5. Towards 100% renewable energy systems: Uncapping power system flexibility

    International Nuclear Information System (INIS)

    Papaefthymiou, G.; Dragoon, Ken

    2016-01-01

    Relying almost entirely on energy from variable renewable resources such as wind and solar energy will require a transformation in the way power systems are planned and operated. This paper outlines the necessary steps in creating power systems with the flexibility needed to maintain stability and reliability while relying primarily on variable energy resources. These steps are provided in the form of a comprehensive overview of policies, technical changes, and institutional systems, organized in three development phases: an initial phase (penetration up to about 10%) characterized by relatively mild changes to conventional power system operations and structures; a dynamic middle phase (up to about 50% penetration) characterized by phasing out conventional generation and a concerted effort to wring flexibility from existing infrastructure; and the high penetration phase that inevitably addresses how power systems operate over longer periods of weeks or months when variable generation will be in either short supply, or in over-abundance. Although this transition is likely a decades-long and incremental process and depends on the specifics of each system, the needed policies, research, demonstration projects and institutional changes need to start now precisely because of the complexity of the transformation. The list of policy actions presented in this paper can serve as a guideline to policy makers on effectuating the transition and on tracking the preparedness of systems. - Highlights: •100% VRES systems: combined analysis of all related technical and policy challenges. •Transition elements: classification of the complete range of challenges in 9 elements. •Development regimes: policy actions in 3 VRES penetration regimes (low-medium-high). •Policies: comprehensive guideline and detailed presentation of policies per regime. •Roadmap: lists of actions per regime act as transition roadmap to 100% VRES systems.

  6. MULTIPLE ECH LAUNCHER CONTROL SYSTEM

    International Nuclear Information System (INIS)

    GREEN, M.T.; PONCE, D.; GRUNLOH, H.J.; ELLIS, R.A.; GROSNICKLE, W.H.; HUMPHREY, R.L.

    2004-03-01

    OAK-B135 The addition of new, high power gyrotrons to the heating and current drive arsenal at DIII-D, required a system upgrade for control of fully steerable ECH Launchers. Each launcher contains two pointing mirrors with two degrees of mechanical freedom. The two flavors of motion are called facet and tilt. Therefore up to four channels of motion per launcher need to be controlled. The system utilizes absolute encoders to indicate mirror position and therefore direction of the microwave beam. The launcher movement is primarily controlled by PLC, but future iterations of design, may require this control to be accomplished by a CPU on fast bus such as Compact PCI. This will be necessary to accomplish real time position control. Safety of equipment and personnel is of primary importance when controlling a system of moving parts. Therefore multiple interlocks and fault status enunciators have been implemented. This paper addresses the design of a Multiple ECH Launcher Control System, and characterizes the flexibility needed to upgrade to a real time position control system in the future

  7. Development of the TRSSS-1 Satellite as the Major Component of the Space Based Information System(SBIS) for Effective Decision Support System for Thailand's Natural Resources and Environmental Management

    OpenAIRE

    Musigasam, Weerapant; Ditsariyakue, Praneet; Aphicholati, Navanit; Vibulsresth, Suvit

    1997-01-01

    The paper describes development of the first Thailand Remote Sensing Satellite System (TRSSS-1) by the National Research Council of Thailand (NRCT), Ministry of Science Technology and Environment (MOSTE). The TRSSS-1 project has primarily been developed as a major component of the Space Base Information System (SBIS) for effective decision support system for Thailand's natural resources and environmental management. The Space Based Information System consists of three components namely, the u...

  8. Feet to the Fire: New Orleans Kids Rethink Their Devastated School System

    Science.gov (United States)

    Wholey, Jane; Burkes, Betty

    2015-01-01

    Kids Rethink New Orleans Schools is an organization of primarily middle school youth that formed after Hurricane Katrina destroyed most of the city's schools. This chapter describes Rethink's first six years of operation, which culminated in school system policy changes and an HBO documentary about the organization's groundbreaking work.

  9. Host-specific and pH-dependent microbiomes of copepods in an extensive rearing system

    DEFF Research Database (Denmark)

    Skovgaard, Alf; Castro Mejia, Josue Leonardo; Hansen, Lars Hestbjerg

    2015-01-01

    copepod production system. Light microscopy and scanning electron microscopy revealed that bacteria were primarily found attached to the exoskeleton of copepods although a few bacteria were also found in the gut as well as internally in skeletal muscle tissue. Through 16S rRNA gene-targeted denaturing...

  10. Active and semi-active control of suspension systems for commercial vehicles based on preview

    NARCIS (Netherlands)

    Kok, J.J.; van Heck, J.G.A.M.; Muijderman, J.H.E.A.; Veldpaus, F.E.

    1997-01-01

    The performance of a vehicle axle/wheel suspension system is primarily determined by the comfort of the occupants, the required working space, the handling properties and, for commercial vehicles in particular, the dynamic tire forces and the load on the chassis components and on the cargo. General

  11. Developing performance measurement systems as enabling formalization : A longitudinal field study of a logistics department

    NARCIS (Netherlands)

    Wouters, Marc; Wilderom, Celeste P.M.

    2008-01-01

    This paper reports on a developmental approach to performance-measurement systems (PMS). In particular, we look at characteristics of a development process that result in the PMS being perceived by employees as enabling of their work, rather than as primarily a control device for use by senior

  12. Controllability of a Class of Bimodal Discrete-Time Piecewise Linear Systems

    NARCIS (Netherlands)

    Yurtseven, E.; Camlibel, M.K.; Heemels, W.P.M.H.

    2013-01-01

    In this paper we will provide algebraic necessary and sufficient conditions for the controllability/reachability/null controllability of a class of bimodal discrete-time piecewise linear systems including several instances of interest that are not covered by existing works which focus primarily on

  13. Spatial agent-based models for socio-ecological systems: challenges and prospects

    NARCIS (Netherlands)

    de Filatova, T.; Verburg, P.H.; Parker, D.C.; Stannard, S.R.

    2013-01-01

    Departing from the comprehensive reviews carried out in the field, we identify the key challenges that agent-based methodology faces when modeling coupled socio-ecological systems. Focusing primarily on the papers presented in this thematic issue, we review progress in spatial agent-based models

  14. Financial performance of a mobile pyrolysis system used to produce biochar from sawmill residues

    Science.gov (United States)

    Dongyeob Kim; Nathaniel McLean Anderson; Woodam Chung

    2015-01-01

    Primary wood products manufacturers generate significant amounts of woody biomass residues that can be used as feedstocks for distributed-scale thermochemical conversion systems that produce valuable bioenergy and bioproducts. However, private investment in these technologies is driven primarily by financial performance, which is often unknown for new technologies with...

  15. Teacher's Guide to Accompany "Artes Latinae," the Encyclopaedia Britannica Latin Instructional System.

    Science.gov (United States)

    Masciantonio, Rudolph; And Others

    This guide, a supplement to the "Artes Latinae Level One Teacher's Manual," prepared for use in the School District of Philadelphia, focuses primarily on how to adapt this course, intended for individualized instruction, to group instruction. Discussion of the multisensory instructional system includes remarks concerning the use of films, study…

  16. Remediation of Stratified Soil Acidity Through Surface Application of Lime in No-Till Cropping Systems

    Science.gov (United States)

    Yield reduction and reduced crop vigor, resulting from soil acidification, are of increasing concern in eastern Washington and northern Idaho. In this region, soil pH has been decreasing at an accelerated rate, primarily due to the long-term use of ammonium based fertilizers. In no-till systems, the...

  17. Characterization and reactions of a Salix extractive with a unique ring system

    Science.gov (United States)

    Lawrence Landucci; Sally Ralph; Kolby Hirth

    2003-01-01

    An extractive compound with a novel ring system was isolated from the wood of Salix alba and was given the name Salucci. The compound was primarily identified from the 1D NMR, 2D NMR and LC-MSMS data and the structure investigated through reactions and derivatizations.

  18. A Fuzzy Logic System to Analyze a Student's Lifestyle

    OpenAIRE

    Ghosh, Sourish; Boob, Aaditya Sanjay; Nikhil, Nishant; Vysyaraju, Nayan Raju; Kumar, Ankit

    2016-01-01

    A college student's life can be primarily categorized into domains such as education, health, social and other activities which may include daily chores and travelling time. Time management is crucial for every student. A self realisation of one's daily time expenditure in various domains is therefore essential to maximize one's effective output. This paper presents how a mobile application using Fuzzy Logic and Global Positioning System (GPS) analyzes a student's lifestyle and provides recom...

  19. BOA II: pipe-asbestos insulation removal system

    International Nuclear Information System (INIS)

    Schempf, H.; Mutschler; Boehmke, S.; Chemel, B.; Piepgras, C.

    1996-01-01

    BOA system is a mobile pipe-external robotic crawler used to remotely strip and bag asbestos-containing lagging and insulation materials from various diameter pipes in (primarily) industrial installations. Steam and process lines within the DOE weapons complex warrant the use of a remote device due to high labor costs and high level of radioactive contamination, making manual removal costly and inefficient. Currently targeted facilities for demonstration and remediation are Fernald in Ohio and Oak Ridge in Tennessee

  20. Building machine learning systems with Python

    CERN Document Server

    Richert, Willi

    2013-01-01

    This is a tutorial-driven and practical, but well-grounded book showcasing good Machine Learning practices. There will be an emphasis on using existing technologies instead of showing how to write your own implementations of algorithms. This book is a scenario-based, example-driven tutorial. By the end of the book you will have learnt critical aspects of Machine Learning Python projects and experienced the power of ML-based systems by actually working on them.This book primarily targets Python developers who want to learn about and build Machine Learning into their projects, or who want to pro

  1. Management Control in Enterprise System Enabled Organizations

    DEFF Research Database (Denmark)

    Rikhardsson, Pall; Rohde, Carsten; Rom, Anders

    2007-01-01

    The objective of this paper is to add to the limited body of knowledge on the relationship between enterprise systems (ES) and management control. Based on a literature review, we describe and classify studies that empirically address this relationship. Apart from not being extensive, the research...... done so far primarily addresses the relationship between management control and ES based on a limited number of methodologies and approaches. We argue that there seems to be a need for more research done from functionalistic and critical perspectives, as well which employs a greater variety...

  2. BOA: Pipe asbestos insulation removal robot system

    International Nuclear Information System (INIS)

    Schempf, H.; Bares, J.; Schnorr, W.

    1995-01-01

    The BOA system is a mobile pipe-external robotic crawler used to remotely strip and bag asbestos-containing lagging and insulation materials (ACLIM) from various diameter pipes in (primarily) industrial installations. Steam and process lines within the DOE weapons complex warrant the use of a remote device due to the high labor costs and high level of radioactive contamination, making manual removal extremely costly and highly inefficient. Currently targeted facilities for demonstration and remediation are Fernald in Ohio and Oak Ridge in Tennessee

  3. Aerobrake concepts for NTP systems study

    Science.gov (United States)

    Cruz, Manuel I.

    1992-01-01

    Design concepts are described for landing large spacecraft masses on the Mars surface in support of manned missions with interplanetary transportation using Nuclear Thermal Propulsion (NTP). Included are the mission and systems analyses, trade studies and sensitivity analyses, design analyses, technology assessment, and derived requirements to support this concept. The mission phases include the Mars de-orbit, entry, terminal descent, and terminal touchdown. The study focuses primarily on Mars surface delivery from orbit after Mars orbit insertion using an NTP. The requirements associated with delivery of logistical supplies, habitats, and other equipment on minimum energy Earth to Mars transfers are also addressed in a preliminary fashion.

  4. The physics of distributed information systems

    International Nuclear Information System (INIS)

    Aurell, Erik

    2013-01-01

    This paper aims to introduce Distributed Systems as a field where the ideas and methods of physics can potentially be applied, and to provide entry points to a wide literature. The contributions of Leslie Lamport, inspired by Relativity Theory, and of Edsger Dijkstra, which has the flavor of a growth process, are discussed at some length. The intent of the author is primarily to stimulate interest in the statistical physics community, and the discussions are therefore framed in a non-technical language; the author apologizes in advance to readers from the computer science side for the unavoidable impreciseness and ambiguities

  5. Laser systems for ablative fractional resurfacing

    DEFF Research Database (Denmark)

    Paasch, Uwe; Haedersdal, Merete

    2011-01-01

    of a variety of skin conditions, primarily chronically photodamaged skin, but also acne and burn scars. In addition, it is anticipated that AFR can be utilized in the laser-assisted delivery of topical drugs. Clinical efficacy coupled with minimal downtime has driven the development of various fractional...... ablative laser systems. Fractionated CO(2) (10,600-nm), erbium yttrium aluminum garnet, 2940-nm and yttrium scandium gallium garnet, 2790-nm lasers are available. In this article, we present an overview of AFR technology, devices and histopathology, and we summarize the current clinical possibilities...

  6. Final Report of Strongly Interacting Fermion Systems

    International Nuclear Information System (INIS)

    Wilkins, J. W.

    2001-01-01

    There has been significant progress in three broad areas: (A) Optical properties, (B) Large-scale computations, and (C) Many-body systems. In this summary the emphasis is primarily on those papers that point to the research plans. At the same time, some important analytic work is not neglected, some of it even appearing in the description of large-scale Computations. Indeed one of the aims of such computations is to give new insights which lead to development of models capable of simple analytic or nearly analytic analysis

  7. Wind energy systems. Application to regional utilities

    Energy Technology Data Exchange (ETDEWEB)

    1979-06-01

    This study developed a generic planning process that utilities can use to determine the feasibility of utilizing WECS (Wind Energy Conversion Systems) as part of their future mix of equipment. While this is primarily an economic process, other questions dealing with WECS availability, capacity credit, operating reserve, performance of WECS arrays, etc., had to be addressed. The approach was to establish the worth, or breakeven value, of WECS to the utility and to determine the impact that WECS additions would have on the utilities mix of conventional source.

  8. Laser systems for ablative fractional resurfacing

    DEFF Research Database (Denmark)

    Paasch, Uwe; Haedersdal, Merete

    2011-01-01

    ablative laser systems. Fractionated CO(2) (10,600-nm), erbium yttrium aluminum garnet, 2940-nm and yttrium scandium gallium garnet, 2790-nm lasers are available. In this article, we present an overview of AFR technology, devices and histopathology, and we summarize the current clinical possibilities...... of a variety of skin conditions, primarily chronically photodamaged skin, but also acne and burn scars. In addition, it is anticipated that AFR can be utilized in the laser-assisted delivery of topical drugs. Clinical efficacy coupled with minimal downtime has driven the development of various fractional...

  9. Design, Development and Implementation of a Smartphone Overdependence Management System for the Self-Control of Smart Devices

    OpenAIRE

    Seo-Joon Lee; Mi Jung Rho; In Hye Yook; Seung-Ho Park; Kwang-Soo Jang; Bum-Joon Park; Ook Lee; Dong Kyun Lee; Dai-Jin Kim; In Young Choi

    2016-01-01

    Background: Smartphone overdependence is a type of mental disorder that requires continuous treatment for cure and prevention. A smartphone overdependence management system that is based on scientific evidence is required. This study proposes the design, development and implementation of a smartphone overdependence management system for self-control of smart devices. Methods: The system architecture of the Smartphone Overdependence Management System (SOMS) primarily consists of four sessions ...

  10. Automating occupational protection records systems

    International Nuclear Information System (INIS)

    Lyon, M.; Martin, J.B.

    1991-10-01

    Occupational protection records have traditionally been generated by field and laboratory personnel, assembled into files in the safety office, and eventually stored in a warehouse or other facility. Until recently, these records have been primarily paper copies, often handwritten. Sometimes, the paper is microfilmed for storage. However, electronic records are beginning to replace these traditional methods. The purpose of this paper is to provide guidance for making the transition to automated record keeping and retrieval using modern computer equipment. This paper describes the types of records most readily converted to electronic record keeping and a methodology for implementing an automated record system. The process of conversion is based on a requirements analysis to assess program needs and a high level of user involvement during the development. The importance of indexing the hard copy records for easy retrieval is also discussed. The concept of linkage between related records and its importance relative to reporting, research, and litigation will be addressed. 2 figs

  11. Data Systems vs. Information Systems

    OpenAIRE

    Amatayakul, Margret K.

    1982-01-01

    This paper examines the current status of “hospital information systems” with respect to the distinction between data systems and information systems. It is proposed that the systems currently existing are incomplete data dystems resulting in ineffective information systems.

  12. Data Matching Imputation System

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The DMIS dataset is a flat file record of the matching of several data set collections. Primarily it consists of VTRs, dealer records, Observer data in conjunction...

  13. Handling effluent from nuclear thermal propulsion system ground tests

    International Nuclear Information System (INIS)

    Shipers, L.R.; Allen, G.C.

    1992-01-01

    A variety of approaches for handling effluent from nuclear thermal propulsion system ground tests in an environmentally acceptable manner are discussed. The functional requirements of effluent treatment are defined and concept options are presented within the framework of these requirements. System concepts differ primarily in the choice of fission-product retention and waste handling concepts. The concept options considered range from closed cycle (venting the exhaust to a closed volume or recirculating the hydrogen in a closed loop) to open cycle (real time processing and venting of the effluent). This paper reviews the different methods to handle effluent from nuclear thermal propulsion system ground tests

  14. Effluent treatment options for nuclear thermal propulsion system ground tests

    International Nuclear Information System (INIS)

    Shipers, L.R.; Brockmann, J.E.

    1992-01-01

    A variety of approaches for handling effluent from nuclear thermal propulsion system ground tests in an environmentally acceptable manner are discussed. The functional requirements of effluent treatment are defined and concept options are presented within the framework of these requirements. System concepts differ primarily in the choice of fission-product retention and waste handling concepts. The concept options considered range from closed cycle (venting the exhaust to a closed volume or recirculating the hydrogen in a closed loop) to open cycle (real time processing and venting of the effluent). This paper reviews the strengths and weaknesses of different methods to handle effluent from nuclear thermal propulsion system ground tests

  15. Surface moisture measurement system hardware acceptance test procedure

    International Nuclear Information System (INIS)

    Ritter, G.A.

    1996-01-01

    The purpose of this acceptance test procedure is to verify that the mechanical and electrical features of the Surface Moisture Measurement System are operating as designed and that the unit is ready for field service. This procedure will be used in conjunction with a software acceptance test procedure, which addresses testing of software and electrical features not addressed in this document. Hardware testing will be performed at the 306E Facility in the 300 Area and the Fuels and Materials Examination Facility in the 400 Area. These systems were developed primarily in support of Tank Waste Remediation System (TWRS) Safety Programs for moisture measurement in organic and ferrocyanide watch list tanks

  16. [The G-DRG System 2009--relevant changes for rheumatology].

    Science.gov (United States)

    Fiori, W; Liedtke-Dyong, A; Lakomek, H-J; Buscham, K; Lehmann, H; Liman, W; Fuchs, A-K; Bessler, F; Roeder, N

    2010-05-01

    The following article presents the major general and specific changes in the G-DRG system, in the classification systems for diagnoses and procedures as well as for the billing process for 2010. Since the G-DRG system is primarily a tool for the redistribution of resources, every hospital needs to analyze the economic effects of the changes by applying the G-DRG transition-grouper to its own cases. Depending on their clinical focus, rheumatological departments may experience positive or negative consequences from the adjustments. In addition, relevant current case law is considered.

  17. EXPERT SYSTEMS

    OpenAIRE

    Georgiana Marin; Mihai Catalin Andrei

    2011-01-01

    In recent decades IT and computer systems have evolved rapidly in economic informatics field. The goal is to create user friendly information systems that respond promptly and accurately to requests. Informatics systems evolved into decision assisted systems, and such systems are converted, based on gained experience, in expert systems for creative problem solving that an organization is facing. Expert systems are aimed at rebuilding human reasoning on the expertise obtained from experts, sto...

  18. System design considerations for fast-neutron interrogation systems

    International Nuclear Information System (INIS)

    Micklich, B.J.; Curry, B.P.; Fink, C.L.; Smith, D.L.; Yule, T.J.

    1993-01-01

    Nonintrusive interrogation techniques that employ fast neutrons are of interest because of their sensitivity to light elements such as carbon, nitrogen, and oxygen. The primary requirement of a fast-neutron inspection system is to determine the value of atomic densities, or their ratios, over a volumetric grid superimposed on the object being interrogated. There are a wide variety of fast-neutron techniques that can provide this information. The differences between the various nuclear systems can be considered in light of the trade-offs relative to the performance requirements for each system's components. Given a set of performance criteria, the operational requirements of the proposed nuclear systems may also differ. For instance, resolution standards will drive scanning times and tomographic requirements, both of which vary for the different approaches. We are modelling a number of the fast-neutron interrogation techniques currently under consideration, to include Fast Neutron Transmission Spectroscopy (FNTS), Pulsed Fast Neutron Analysis (PFNA), and its variant, 14-MeV Associated Particle Imaging (API). The goals of this effort are to determine the component requirements for each technique, identify trade-offs that system performance standards impose upon those component requirements, and assess the relative advantages and disadvantages of the different approaches. In determining the component requirements, we will consider how they are driven by system performance standards, such as image resolution, scanning time, and statistical uncertainty. In considering the trade-offs between system components, we concentrate primarily on those which are common to all approaches, for example: source characteristics versus detector array requirements. We will then use the analysis to propose some figures-of-merit that enable performance comparisons between the various fast-neutron systems under consideration. The status of this ongoing effort is presented

  19. System identification of the Arabidopsis plant circadian system

    Science.gov (United States)

    Foo, Mathias; Somers, David E.; Kim, Pan-Jun

    2015-02-01

    The circadian system generates an endogenous oscillatory rhythm that governs the daily activities of organisms in nature. It offers adaptive advantages to organisms through a coordination of their biological functions with the optimal time of day. In this paper, a model of the circadian system in the plant Arabidopsis (species thaliana) is built by using system identification techniques. Prior knowledge about the physical interactions of the genes and the proteins in the plant circadian system is incorporated in the model building exercise. The model is built by using primarily experimentally-verified direct interactions between the genes and the proteins with the available data on mRNA and protein abundances from the circadian system. Our analysis reveals a great performance of the model in predicting the dynamics of the plant circadian system through the effect of diverse internal and external perturbations (gene knockouts and day-length changes). Furthermore, we found that the circadian oscillatory rhythm is robust and does not vary much with the biochemical parameters except those of a light-sensitive protein P and a transcription factor TOC1. In other words, the circadian rhythmic profile is largely a consequence of the network's architecture rather than its particular parameters. Our work suggests that the current experimental knowledge of the gene-to-protein interactions in the plant Arabidopsis, without considering any additional hypothetical interactions, seems to suffice for system-level modeling of the circadian system of this plant and to present an exemplary platform for the control of network dynamics in complex living organisms.

  20. The Integrated Air Transportation System Evaluation Tool

    Science.gov (United States)

    Wingrove, Earl R., III; Hees, Jing; Villani, James A.; Yackovetsky, Robert E. (Technical Monitor)

    2002-01-01

    Throughout U.S. history, our nation has generally enjoyed exceptional economic growth, driven in part by transportation advancements. Looking forward 25 years, when the national highway and skyway systems are saturated, the nation faces new challenges in creating transportation-driven economic growth and wealth. To meet the national requirement for an improved air traffic management system, NASA developed the goal of tripling throughput over the next 20 years, in all weather conditions while maintaining safety. Analysis of the throughput goal has primarily focused on major airline operations, primarily through the hub and spoke system.However, many suggested concepts to increase throughput may operate outside the hub and spoke system. Examples of such concepts include the Small Aircraft Transportation System, civil tiltrotor, and improved rotorcraft. Proper assessment of the potential contribution of these technologies to the domestic air transportation system requires a modeling capability that includes the country's numerous smaller airports, acting as a fundamental component of the National Air space System, and the demand for such concepts and technologies. Under this task for NASA, the Logistics Management Institute developed higher fidelity demand models that capture the interdependence of short-haul air travel with other transportation modes and explicitly consider the costs of commercial air and other transport modes. To accomplish this work, we generated forecasts of the distribution of general aviation based aircraft and GA itinerant operations at each of nearly 3.000 airport based on changes in economic conditions and demographic trends. We also built modules that estimate the demand for travel by different modes, particularly auto, commercial air, and GA. We examined GA demand from two perspectives: top-down and bottom-up, described in detail.

  1. Multibody Systems

    DEFF Research Database (Denmark)

    Wagner, Falko Jens

    1999-01-01

    Multibody Systems is one area, in which methods for solving DAEs are of special interst. This chapter is about multibody systems, why they result in DAE systems and what kind of problems that can arise when dealing with multibody systems and formulating their corresponding DAE system....

  2. Data acquisition systems at Fermilab

    International Nuclear Information System (INIS)

    Votava, M.

    1999-01-01

    Experiments at Fermilab require an ongoing program of development for high speed, distributed data acquisition systems. The physics program at the lab has recently started the operation of a Fixed Target run in which experiments are running the DART[1] data acquisition system. The CDF and D experiments are preparing for the start of the next Collider run in mid 2000. Each will read out on the order of 1 million detector channels. In parallel, future experiments such as BTeV R ampersand D and Minos have already started prototype and test beam work. BTeV in particular has challenging data acquisition system requirements with an input rate of 1500 Gbytes/sec into Level 1 buffers and a logging rate of 200 Mbytes/sec. This paper will present a general overview of these data acquisition systems on three fronts those currently in use, those to be deployed for the Collider Run in 2000, and those proposed for future experiments. It will primarily focus on the CDF and D architectures and tools

  3. Technical specification for vacuum systems

    International Nuclear Information System (INIS)

    Khaw, J.

    1987-01-01

    The vacuum systems at the Stanford Linear Accelerator Center (SLAC) are primarily of all-metal construction and operate at pressures from 10 -5 to 10 -11 Torr. The primary gas loads during operation result from thermal desorption and beam-induced desorption from the vacuum chamber walls. These desorption rates can be extremely high in the case of hydrocarbons and other contaminants. These specifications place a major emphasis on eliminating contamination sources. The specifications and procedures have been written to insure the cleanliness and vacuum integrity of all SLAC vacuum systems, and to assist personnel involved with SLAC vacuum systems in choosing and designing components that are compatible with existing systems and meet the quality and reliability of SLAC vacuum standards. The specification includes requirements on design, procurement, fabrication, chemical cleaning, clean room practices, welding and brazing, helium leak testing, residual gas analyzer testing, bakeout, venting, and pumpdown. Also appended are specifications regarding acceptable vendors, isopropyl alcohol, bakeable valve cleaning procedure, mechanical engineering safety inspection, notes on synchrotron radiation, and specifications of numerous individual components

  4. Heat transfer fluids for solar DHW systems

    Energy Technology Data Exchange (ETDEWEB)

    Wedel, S.; Bezzel, E.

    2000-07-01

    The aim of this work was to investigate the sudden clogging of the pipes in collectors as a consequence of liquid deterioration after repeated boiling during stagnation. A method to perform simple screening as accelerated tests of a large number liquid of samples subjected to various chemical- and physical environments have been designed. The acceleration factor of experiments relative to real systems is quite substantial primarily due to the extensive stress cycles in tests. Possible degradation mechanisms have been investigated and generally, there are two different paths to degradation of glycol: Thermal degradation and oxidative degradation primarily yielding propylene derivatives and carboxylic acids respectively. Polymerisation is an obvious possibility in a system containing various organic compounds such as acids and alcohols. Consequently, the reaction patterns alter making room for alternative interconnected mechanisms thus generating a broad spectrum of possible degradation products. Reserve alkalinity and pH are somewhat unreliable means of solely estimating the state of a liquid in relation to degradation and precipitation, as curvature of the RA-pH relations are different from liquid to liquid. For the majority of liquids, precipitation is not correlated with pH and RA. Coloration and precipitation in the liquid phase during stagnation separated liquids in two sub-categories. Fluids with inhibitor have sparing to moderate sedimentation and are brownish-black due to deterioration. Glycols without additives were either pale or colourless and did not precipitate. During normal operation, all fluids are clear and transparent and the majority has the same initial colour. The same distinction in liquids was observed on examination on the inside surface of the tubes concerning extent and the quantity of deposit. Liquids with additives tend to have significantly more deposit covering a larger surface than liquids without. Visual evaluation has proved that

  5. Overview of the land analysis system (LAS)

    Science.gov (United States)

    Quirk, Bruce K.; Olseson, Lyndon R.

    1987-01-01

    The Land Analysis System (LAS) is a fully integrated digital analysis system designed to support remote sensing, image processing, and geographic information systems research. LAS is being developed through a cooperative effort between the National Aeronautics and Space Administration Goddard Space Flight Center and the U. S. Geological Survey Earth Resources Observation Systems (EROS) Data Center. LAS has over 275 analysis modules capable to performing input and output, radiometric correction, geometric registration, signal processing, logical operations, data transformation, classification, spatial analysis, nominal filtering, conversion between raster and vector data types, and display manipulation of image and ancillary data. LAS is currently implant using the Transportable Applications Executive (TAE). While TAE was designed primarily to be transportable, it still provides the necessary components for a standard user interface, terminal handling, input and output services, display management, and intersystem communications. With TAE the analyst uses the same interface to the processing modules regardless of the host computer or operating system. LAS was originally implemented at EROS on a Digital Equipment Corporation computer system under the Virtual Memorial System operating system with DeAnza displays and is presently being converted to run on a Gould Power Node and Sun workstation under the Berkeley System Distribution UNIX operating system.

  6. ASSEMBLY TRANSFER SYSTEM DESCRIPTION DOCUMENT

    International Nuclear Information System (INIS)

    Gorpani, B.

    2000-01-01

    The Assembly Transfer System (ATS) receives, cools, and opens rail and truck transportation casks from the Carrier/Cask Handling System (CCHS). The system unloads transportation casks consisting of bare Spent Nuclear Fuel (SNF) assemblies, single element canisters, and Dual Purpose Canisters (DPCs). For casks containing DPCs, the system opens the DPCs and unloads the SNF. The system stages the assemblies, transfer assemblies to and from fuel-blending inventory pools, loads them into Disposal Containers (DCs), temporarily seals and inerts the DC, decontaminates the DC and transfers it to the Disposal Container Handling System. The system also prepares empty casks and DPCs for off-site shipment. Two identical Assembly Transfer System lines are provided in the Waste Handling Building (WHB). Each line operates independently to handle the waste transfer throughput and to support maintenance operations. Each system line primarily consists of wet and dry handling areas. The wet handling area includes a cask transport system, cask and DPC preparation system, and a wet assembly handling system. The basket transport system forms the transition between the wet and dry handling areas. The dry handling area includes the dry assembly handling system, assembly drying system, DC preparation system, and DC transport system. Both the wet and dry handling areas are controlled by the control and tracking system. The system operating sequence begins with moving transportation casks to the cask preparation area. The cask preparation operations consist of cask cavity gas sampling, cask venting, cask cool-down, outer lid removal, and inner shield plug lifting fixture attachment. Casks containing bare SNF (no DPC) are filled with water and placed in the cask unloading pool. The inner shield plugs are removed underwater. For casks containing a DPC, the cask lid(s) is removed, and the DPC is penetrated, sampled, vented, and cooled. A DPC lifting fixture is attached and the cask is placed

  7. System dynamics

    International Nuclear Information System (INIS)

    Kim, Do Hun; Mun, Tae Hun; Kim, Dong Hwan

    1999-02-01

    This book introduces systems thinking and conceptual tool and modeling tool of dynamics system such as tragedy of single thinking, accessible way of system dynamics, feedback structure and causal loop diagram analysis, basic of system dynamics modeling, causal loop diagram and system dynamics modeling, information delay modeling, discovery and application for policy, modeling of crisis of agricultural and stock breeding products, dynamic model and lesson in ecosystem, development and decadence of cites and innovation of education forward system thinking.

  8. Disassembly automation automated systems with cognitive abilities

    CERN Document Server

    Vongbunyong, Supachai

    2015-01-01

    This book presents a number of aspects to be considered in the development of disassembly automation, including the mechanical system, vision system and intelligent planner. The implementation of cognitive robotics increases the flexibility and degree of autonomy of the disassembly system. Disassembly, as a step in the treatment of end-of-life products, can allow the recovery of embodied value left within disposed products, as well as the appropriate separation of potentially-hazardous components. In the end-of-life treatment industry, disassembly has largely been limited to manual labor, which is expensive in developed countries. Automation is one possible solution for economic feasibility. The target audience primarily comprises researchers and experts in the field, but the book may also be beneficial for graduate students.

  9. Smart energy and smart energy systems

    DEFF Research Database (Denmark)

    Lund, Henrik; Østergaard, Poul Alberg; Connolly, David

    2017-01-01

    In recent years, the terms “Smart Energy” and “Smart Energy Systems” have been used to express an approach that reaches broader than the term “Smart grid”. Where Smart Grids focus primarily on the electricity sector, Smart Energy Systems take an integrated holistic focus on the inclusion of more...... sectors (electricity, heating, cooling, industry, buildings and transportation) and allows for the identification of more achievable and affordable solutions to the transformation into future renewable and sustainable energy solutions. This paper first makes a review of the scientific literature within...... the field. Thereafter it discusses the term Smart Energy Systems with regard to the issues of definition, identification of solu- tions, modelling, and integration of storage. The conclusion is that the Smart Energy System concept represents a scientific shift in paradigms away from single-sector thinking...

  10. Radio transmission system for industrial area

    International Nuclear Information System (INIS)

    Iliescu, M.; Culcer, M.; Curuia, M.; Anghel, N.M.; Stefanescu, I.

    2003-01-01

    The paper deals with a data transmission system operating in a large, noisy industrial area. The radio transmission system permits data and commands communication between the local units of collecting data and a central monitoring and/or command station ( dispatch). The communication support are radio waves in the range 450 MHz. The transducers are of transmitter type, with 4-20 mA output signal, providing information about environmental and/or work parameters. Data are primarily acquisitioned in a data logger with microcontroller, then transmitted via a FSK radio modem and a radio station to the dispatch. Data logger can also be connected in a network. The dispatch personal computer receives and processes data and transmits commands. The system functioning is supervised by a communication software in MCS - 51 assembler and an application software in Visual C ++ . (author)

  11. Using session types as an effect system

    Directory of Open Access Journals (Sweden)

    Dominic Orchard

    2016-02-01

    Full Text Available Side effects are a core part of practical programming. However, they are often hard to reason about, particularly in a concurrent setting. We propose a foundation for reasoning about concurrent side effects using sessions. Primarily, we show that session types are expressive enough to encode an effect system for stateful processes. This is formalised via an effect-preserving encoding of a simple imperative language with an effect system into the pi-calculus with session primitives and session types (into which we encode effect specifications. This result goes towards showing a connection between the expressivity of session types and effect systems. We briefly discuss how the encoding could be extended and applied to reason about and control concurrent side effects.

  12. Reconfigurable Manufacturing System Design and Implementation

    DEFF Research Database (Denmark)

    Hadar, Ronen; Bilberg, Arne

    2013-01-01

    is meant primarily to show the physical feasibility of the system and provide a first-look into a real production application of the RMS ideas. The purpose of this paper is to present the design of the manufacturer’s RMS proof of concept, its implementation, and evaluation results.......Reconfigurable Manufacturing Systems (RMS) have been an increasing area of interest in the research arena. However, it seems that current literature is lacking application and implementation cases where RMS are simulated, tested, and evaluated as a feasible manufacturing concept. A Manufacturer...... of Consumer Goods identified the potential of the RMS concept and decided to investigate the concept in a real production installation. The result of this development is a proof of concept of a changeable and reconfigurable assembly and decoration system based on the principles of RMS. This proof of concept...

  13. TOXPERT: An Expert System for Risk Assessment

    Science.gov (United States)

    Soto, R. J.; Osimitz, T. G.; Oleson, A.

    1988-01-01

    TOXPERT is an artificial intelligence based system used to model product safety, toxicology (TOX) and regulatory (REG) decision processes. An expert system shell uses backward chaining rule control to link “marketing approval” goals to the type of product, REG agency, exposure conditions and TOX. Marketing risks are primarily a function of the TOX, hazards and exposure potential. The method employed differentiates between REG requirements in goal seeking control for various types of products. This is accomplished by controlling rule execution by defining frames for each REG agency. In addition, TOXPERT produces classifications of TOX ratings and suggested product labeling. This production rule system uses principles of TOX, REGs, corporate guidelines and internal “rules of thumb.” TOXPERT acts as an advisor for this narrow domain. Advantages are that it can make routine decisions freeing professional's time for more complex problem solving, provide backup and training.

  14. International Conference on Intelligent Unmanned Systems (ICIUS)

    CERN Document Server

    Kartidjo, Muljowidodo; Yoon, Kwang-Joon; Budiyono, Agus; Autonomous Control Systems and Vehicles : Intelligent Unmanned Systems

    2013-01-01

    The International Conference on Intelligent Unmanned Systems 2011 was organized by the International Society of Intelligent Unmanned Systems and locally by the Center for Bio-Micro Robotics Research at Chiba University, Japan. The event was the 7th conference continuing from previous conferences held in Seoul, Korea (2005, 2006), Bali, Indonesia (2007), Nanjing, China (2008), Jeju, Korea (2009), and Bali, Indonesia (2010). ICIUS 2011 focused on both theory and application, primarily covering the topics of robotics, autonomous vehicles, intelligent unmanned technologies, and biomimetics. We invited seven keynote speakers who dealt with related state-of-the-art technologies including unmanned aerial vehicles (UAVs) and micro air vehicles (MAVs), flapping wings (FWs), unmanned ground vehicles (UGVs), underwater vehicles (UVs), bio-inspired robotics, advanced control, and intelligent systems, among others. This book is a collection of excellent papers that were updated after presentation at ICIUS2011. All papers ...

  15. An expert system for diesel generator diagnostics

    International Nuclear Information System (INIS)

    Bley, D.C.; Read, J.W.; Kaplan, S.; Liming, J.K.; Brosee, N.M.; Hanley, D.W.

    1987-01-01

    The idea of developing artificial intelligence (AI) systems to capture the knowledge of human experts is receiving much attention these days. The idea is even more attractive when important expertise resides within a single individual, especially one who is nearing retirement and who has not otherwise recorded or passed along his important knowledge and thought processes. The diesel generators at Pilgrim Nuclear Power Station have performed exceptionally well, primarily due to the care and attention of one man. Therefore, the authors are constructing an expert system for the diagnosis of diesel generator problems at Pilgrim. This paper includes a description of the expert system design and operation, examples from the knowledge base, and sample diagnoses, so the reader can observe the process in action

  16. An assessment of the impact of trauma systems consultation on the level of trauma system development.

    Science.gov (United States)

    Winchell, Robert J; Ball, Jane W; Cooper, Gail F; Sanddal, Nels D; Rotondo, Michael F

    2008-11-01

    Studies have shown that trauma systems decrease morbidity and mortality after injury. Despite these findings, overall progress in system development has been slow and inconsistent. The American College of Surgeons Committee on Trauma (COT) has developed a process to provide expert consultation to facilitate regional trauma system development. This study evaluated the progress that occurred after COT consultation visits in six regional systems. All six trauma systems undergoing COT consultation between January 1, 2004 and September 1, 2006 were included in the study. Using a set of 16 objective indicators, preconsultation status was retrospectively assessed by members of the original consultation team using data from the final consultation reports. Postconsultation status was assessed by directed telephone conference, conducted by members of the original consultation team with current key representatives from each system. Progress was assessed by comparing changes in both aggregate and individual indicator scores. This study showed a statistically significant increase in aggregate indicator scores after consultation. The largest gains were seen in systems with the longest time interval between the two assessments. Individual indicators related to system planning and quality assurance infrastructure showed the most improvement. Little or no change was seen in indicators related to system funding. The COT consultation process appears to be effective in facilitating regional trauma system development. In this short-term followup study, progress was seen primarily in areas related to planning and system design. Consultation was not effective in helping systems secure stable funding.

  17. Algorithm & SoC design for automotive vision systems for smart safe driving system

    CERN Document Server

    Shin, Hyunchul

    2014-01-01

    An emerging trend in the automobile industry is its convergence with information technology (IT). Indeed, it has been estimated that almost 90% of new automobile technologies involve IT in some form. Smart driving technologies that improve safety as well as green fuel technologies are quite representative of the convergence between IT and automobiles. The smart driving technologies include three key elements: sensing of driving environments, detection of objects and potential hazards, and the generation of driving control signals including warning signals. Although radar-based systems are primarily used for sensing the driving environments, the camera has gained importance in advanced driver assistance systems(ADAS). This book covers system-on-a-chip (SoC) designs—including both algorithms and hardware—related with image sensing and object detection by using the camera for smart driving systems. It introduces a variety of algorithms such as lens correction, super resolution, image enhancement, and object ...

  18. The integration between Business Model Canvas and Manufacturing System Design

    Science.gov (United States)

    Prasetyawan, Y.; Maulida, N.; Lutvitasari, M. R.

    2018-04-01

    Business Model Canvas (BMC) is an increasingly popular business design tool especially for a start-up business and new business player. In general, BMC seeks a balance between effective working patterns with suppliers, good relation with customers and ability to understand and manage internal resources. This balance will expedite the implementation of Manufacturing System Design (MSD). The existing use of BMC and MSD is frequently applied separately at various business levels. BMC business plan is primarily to have engagement with customers and explore potential revenue to increase profits, while MSD primarily aims to meet production targets with available resources. The purpose of this research is to provide a roadmap to align BMC and MSD. A series of simple mathematical (modified) and integration models are created to connect BMC and MSD. Several results in various industries (new, developed and mature) are presented and used as examples of implementation.

  19. A Lean Approach to Improving SE Visibility in Large Operational Systems Evolution

    Science.gov (United States)

    2013-06-01

    engineering activities in such instances. An initial generalization of pull concepts using a standard kanban approach was developed. During the development... Kanban -based Scheduling System (KSS) (Turner, Lane, et al. 2012). The second phase of this research is describing an implementation of the KSS concept...software and systems engineering tasks and the required capabilities. Because kanban concepts have been primarily used with single level value streams

  20. Source-to-Sink: An Earth/Mars Comparison of Boundary Conditions for Eolian Dune Systems

    OpenAIRE

    Kocurek, Gary; Ewing, Ryan C.

    2012-01-01

    Eolian dune fields on Earth and Mars evolve as complex systems within a set of boundary conditions. A source-to-sink comparison indicates that although differences exist in sediment production and transport, the systems largely converge at the dune-flow and pattern-development levels, but again differ in modes of accumulation and preservation. On Earth, where winds frequently exceed threshold speeds, dune fields are sourced primarily through deflation of subaqueous deposits as these sediments...

  1. Design and application of the MARK IV scanning system for radionuclide computed tomography of the brain

    International Nuclear Information System (INIS)

    Kuhl, D.E.; Hoffman, E.J.; Phelps, M.E.; Ricci, A.; Reivich, M.

    1976-01-01

    The MARK IV radioisotope scanning system was built to provide fast and accurate radionuclide computed tomography (RCT). It is designed primarily for detecting commonly available radioactive labels such as /sup 99m/Tc, but it is also adapted to detecting positron emitters such as 18 F. The system has interlaced convergent collimation in a 4-sided arrangement of 32-independent detectors which continuously rotate as a unit, detecting, processing, and displaying the reconstructed data while the study progresses

  2. Simple messaging and collaboration system for heterogeneous organizations operating in disaster environments

    OpenAIRE

    Meyer, Ramsey

    2011-01-01

    Approved for public release; distribution is unlimited. A novel communication system for use by a wide variety of first responders in disaster response is described. The system is based primarily on SMS messaging technologies and either indigenous mobile phone service providers or mobile phone service brought in via cellular-on-wheels (COWs), UAVs, rapidly deployed towers, etc. End users use either their own cell phones, running a native SMS application, or low-cost phones that are dist...

  3. Coupling component systems towards systems of systems

    OpenAIRE

    Autran , Frédéric; Auzelle , Jean-Philippe; Cattan , Denise; Garnier , Jean-Luc; Luzeaux , Dominique; Mayer , Frédérique; Peyrichon , Marc; Ruault , Jean-René

    2008-01-01

    International audience; Systems of systems (SoS) are a hot topic in our "fully connected global world". Our aim is not to provide another definition of what SoS are, but rather to focus on the adequacy of reusing standard system architecting techniques within this approach in order to improve performance, fault detection and safety issues in large-scale coupled systems that definitely qualify as SoS, whatever the definition is. A key issue will be to secure the availability of the services pr...

  4. Systems effectiveness

    CERN Document Server

    Habayeb, A R

    1987-01-01

    Highlights three principal applications of system effectiveness: hardware system evaluation, organizational development and evaluation, and conflict analysis. The text emphasizes the commonality of the system effectiveness discipline. The first part of the work presents a framework for system effectiveness, partitioning and hierarchy of hardware systems. The second part covers the structure, hierarchy, states, functions and activities of organizations. Contains an extended Appendix on mathematical concepts and also several project suggestions.

  5. Auxiliary systems

    International Nuclear Information System (INIS)

    Meyer, P.J.

    1981-01-01

    Systems included under the heading ''Reactor Auxillary Systems'' are those immediately involved with the reactor operation. These include the systems for dosing and letdown of reactor coolant, as well as for the chemical dosing, purification and treatment of the reactor coolant and the cooling system in the controlled area. The ancillary systems are mainly responsible for liquid and gaseous treatment and the waste treatment for final storage. (orig.)

  6. JESS: Java extensible snakes system

    Science.gov (United States)

    McInerney, Tim; Akhavan Sharif, M. Reza; Pashotanizadeh, Nasrin

    2005-04-01

    Snakes (Active Contour Models) are powerful model-based image segmentation tools. Although researchers have proven them especially useful in medical image analysis over the past decade, Snakes have remained primarily in the academic world and they have not become widely used in clinical practice or widely available in commercial packages. A number of confusing and specialized variants exist and there has been no standard open-source implementation available. To address this problem, we present a Java Extensible Snakes System (JESS) that is general, portable, and extensible. The system uses Java Swing classes to allow for the rapid development of custom graphical user interfaces (GUI's). It also incorporates the Java Advanced Imaging(JAI) class library, which provide custom image preprocessing, image display and general image I/O. The Snakes algorithm itself is written in a hierarchical fashion, consisting of a general Snake class and several subclasses that span the main variants of Snakes including a new, powerful, robust subdivision-curve Snake. These subclasses can be easily and quickly extended and customized for any specific segmentation and analysis task. We demonstrate the utility of these classes for segmenting various anatomical structures from 2D medical images. We also demonstrate the effectiveness of JESS by using it to rapidly build a prototype semi-automatic sperm analysis system. The JESS software will be made publicly available in early 2005.

  7. TPX heating and cooling system

    International Nuclear Information System (INIS)

    Kungl, D.J.; Knutson, D.S.; Costello, J.; Stoenescu, S.; Yemin, L.

    1995-01-01

    TPX, while having primarily super-conducting coils that do not require water cooling, still has very significant water cooling requirements for the plasma heating systems, vacuum vessel, plasma facing components, diagnostics, and ancillary equipment. This is accentuated by the 1000-second pulse requirement. Two major design changes, which have significantly affected the TPX Heating and Cooling System, have been made since the conceptual design review in March of 1993. This paper will discuss these changes and review the current status of the conceptual design. The first change involves replacing the vacuum vessel neutron shielding configuration of lead/glass composite tile by a much simpler and more reliable borated water shield. The second change reduces the operating temperature of the vacuum vessel from 150 C to ≥50 C. With this temperature reduction, all in-vessel components and the vessel will be supplied by coolant at a common ≥50 C inlet temperature. In all, six different heating and cooling supply requirements (temperature, pressure, water quality) for the various TPX components must be met. This paper will detail these requirements and provide an overview of the Heating and Cooling System design while focusing on the ramifications of the TPX changes described above

  8. Safeguards as an evolutionary system

    International Nuclear Information System (INIS)

    Carlson, J.

    1998-01-01

    NPT safeguards pursuant to INFCIRC/153 retain a strong emphasis on materials accountancy, and are primarily concerned with verifying nuclear activities as declared by the State - the correctness of States' declarations. This decade, failure to adequately address the possibility of undeclared nuclear activities - the issue of the completeness of States' declarations - has been recognized as a major shortcoming in the safeguards system. Since the 'classical' safeguards system is unable to provide credible assurance of the absence of clandestine nuclear activities, substantial efforts are being made to strengthen the IAEA's capabilities in this regard. Agreement has been reached on a Model Protocol substantially extending the Agency's authority, and good progress has been made in developing the new approaches, technologies and techniques required to ensure this authority is used effectively. Increasingly, safeguards will involve more qualitative judgements. Transparency will be very important - without a clear understanding by Member States of how the Agency goes about its new tasks and reaches its conclusions about the absence of undeclared activities, the safeguards system will not fulfil its vital confidence-building role. A major theme in current safeguards thinking is integration, the rationalization of classical safeguards with the new safeguards strengthening measures. As part of the rationalization process, it is timely to re-assess traditional safeguards implementation practices. One of these is uniformity in the way safeguards activities are implemented in different States. Another is whether the traditional concept of safeguards confidentiality is consistent with the increasing importance of transparency. (author)

  9. USES 2.0, The Uniform System for the Evaluation of Substances, version 2.0 ; supplement to EUSES

    OpenAIRE

    Linders JBHJ; Jager DT (eds.); CSR; ECO

    1997-01-01

    This interim report describes the updated risk assessment system for agricultural and non-agricultural pesticides. It will be integrated with the European Union System for the Evaluation of Substances, EUSES 1.0, into USES 2.0, the second version of the Uniform System for the Evaluation of Substances. The report is primarily made as preparation to the programming and testing of USES 2.0.

  10. Description of the grout system dynamic simulation

    International Nuclear Information System (INIS)

    Zimmerman, B.D.

    1993-07-01

    The grout system dynamic computer simulation was created to allow investigation of the ability of the grouting system to meet established milestones, for various assumed system configurations and parameters. The simulation simulates the movement of tank waste through the system versus time, from initial storage tanks, through feed tanks and the grout plant, then finally to a grout vault. The simulation properly accounts for the following (1) time required to perform various actions or processes, (2) delays involved in gaining regulatory approval, (3) random system component failures, (4) limitations on equipment capacities, (5) available parallel components, and (6) different possible strategies for vault filling. The user is allowed to set a variety of system parameters for each simulation run. Currently, the output of a run primarily consists of a plot of projected grouting campaigns completed versus time, for comparison with milestones. Other outputs involving any model component can also be quickly created or deleted as desired. In particular, sensitivity runs where the effect of varying a model parameter (flow rates, delay times, number of feed tanks available, etc.) on the ability of the system to meet milestones can be made easily. The grout system simulation was implemented using the ITHINK* simulation language for Macintosh** computers

  11. Safety of Systemic Agents for the Treatment of Pediatric Psoriasis.

    Science.gov (United States)

    Bronckers, Inge M G J; Seyger, Marieke M B; West, Dennis P; Lara-Corrales, Irene; Tollefson, Megha; Tom, Wynnis L; Hogeling, Marcia; Belazarian, Leah; Zachariae, Claus; Mahé, Emmanuel; Siegfried, Elaine; Philipp, Sandra; Szalai, Zsuzsanna; Vleugels, Ruth Ann; Holland, Kristen; Murphy, Ruth; Baselga, Eulalia; Cordoro, Kelly; Lambert, Jo; Alexopoulos, Alex; Mrowietz, Ulrich; Kievit, Wietske; Paller, Amy S

    2017-11-01

    Use of systemic therapies for moderate to severe psoriasis in children is increasing, but comparative data on their use and toxicities are limited. To assess patterns of use and relative risks of systemic agents for moderate to severe psoriasis in children. A retrospective review was conducted at 20 centers in North America and Europe, and included all consecutive children with moderate to severe psoriasis who used systemic medications or phototherapy for at least 3 months from December 1, 1990, to September 16, 2014. The minimal core data set included age, sex, severity of psoriasis, systemic interventions, monitoring, adverse events (AEs), and reason for discontinuation. For 390 children (203 girls and 187 boys; mean [SD] age at diagnosis, 8.4 [3.7] years) with psoriasis who used 1 or more systemic medications, the mean interval between diagnosis and starting systemic therapy was 3.0 years. Methotrexate was used by 270 patients (69.2%), biologic agents (primarily etanercept) by 106 (27.2%), acitretin by 57 (14.6%), cyclosporine by 30 (7.7%), fumaric acid esters by 19 (4.9%), and more than 1 medication was used by 73 (18.7%). Of 270 children taking methotrexate, 130 (48.1%) reported 1 or more AEs associated with methotrexate, primarily gastrointestinal (67 [24.8%]). Folic acid 6 days per week (odds ratio, 0.16; 95% CI, 0.06-0.41; P psoriasis.

  12. Transport and Power System Scenarios for Northern Europe in 2030

    DEFF Research Database (Denmark)

    Juul, Nina; Meibom, Peter

    2009-01-01

    it is assumed that power can go both from grid-to-vehicle and vehicle-to-grid. Oil prices are assumed to be $120/barrel, and CO2 price 40 €/ton. This results in an optimal investment path with a large increase in sustainable energy; primarily wind energy, as well as an increase in the electric drive vehicles......Increasing focus on sustainability affects all parts of the energy system. Integrating the power and transport system in future energy system planning, influences the economically optimal investments and optimal operation of the power system as well as the transport system. This work presents...... analysis of the optimal configuration and operation of the integrated power and transport system in Northern Europe. Optimal configuration and operation is obtained using the optimisation model, Balmorel [1], with a transport model extension. For electric drive vehicles with plug-in capabilities...

  13. Centralization and Decentralization in the TRIUMF control system

    International Nuclear Information System (INIS)

    Dohan, D.A.; Gurd, D.P.

    1984-01-01

    Distributed control is characterized by a number of different concepts relating to hardware, software, data bases, and control stations. Although some control system designs are more centralized than others, all contain elements of both approaches. In particular, the TRIUMF system contains a unique blend of centralized and distributed attributes, deriving primarily from the multi-sourced CAMAC and memory systems at its executive node. The increased demands of an expanding accelerator laboratory have made it timely to consider strategies for expansion of the TRIUMF Control System. These requirements have led to reflections on one of the major themes of this conference - centralized vs distributed digital control systems for accelerators. This paper discusses the way in which the TRIUMF system successfully combines elements of both approaches

  14. CRRIS: a computerized radiological risk-investigation system

    International Nuclear Information System (INIS)

    Baes, C.F. III; Miller, C.W.

    1981-01-01

    The US Environmental Protection Agency (EPA) is responsible for regulating radioactive airborne effluents in the US. A comprehensive, integrated Computerized Radiological Risk Investigation System (CRRIS) is being developed to support EPA's radiation standards development. This modular system consists primarily of five computer codes and their supporting data bases for estimating environmental transport and radiation doses and risks. Health effects are estimated on the basis of a life-table methodology developed by EPA. CRRIS is designed to provide EPA with a reasonable and flexible way of assessing the risk to man associated with radionuclide releases to the atmosphere

  15. Public health system - current status and world experience

    Directory of Open Access Journals (Sweden)

    Andreyeva І.А.

    2016-09-01

    Full Text Available In the review, the evolution of Public Health and global development tendencies of Public Health system have been discussed. Stages of formation of the updated concept, principles of Public Health organization and the role of various organizations have been shown in the connection with development of the global concept of "Health for All". A well-functioning public health system is primarily the result of multisectoral cooperation. The aim of modern Public Health is to provide conditions of access to appropriate and cost-effective health care for all population groups, including health promotion and disease prevention.

  16. Urinary incontinence monitoring system using laser-induced graphene sensors

    KAUST Repository

    Nag, Anindya

    2017-12-25

    This paper presents the design and development of a sensor patch to be used in a sensing system to deal with the urinary incontinence problem primarily faced by women and elderly people. The sensor patches were developed from laser-induced graphene from low-cost commercial polyimide (PI) polymers. The graphene was manually transferred to a commercial tape, which was used as sensor patch for experimentation. Salt solutions with different concentrations were tested to determine the most sensitive frequency region of the sensor. The results are encouraging to further develop this sensor in a platform for a fully functional urinary incontinence detection system.

  17. Surface moisture measurement system hardware acceptance test report

    Energy Technology Data Exchange (ETDEWEB)

    Ritter, G.A., Westinghouse Hanford

    1996-05-28

    This document summarizes the results of the hardware acceptance test for the Surface Moisture Measurement System (SMMS). This test verified that the mechanical and electrical features of the SMMS functioned as designed and that the unit is ready for field service. The bulk of hardware testing was performed at the 306E Facility in the 300 Area and the Fuels and Materials Examination Facility in the 400 Area. The SMMS was developed primarily in support of Tank Waste Remediation System (TWRS) Safety Programs for moisture measurement in organic and ferrocyanide watch list tanks.

  18. 1st International Conference on Signal, Networks, Computing, and Systems

    CERN Document Server

    Mohapatra, Durga; Nagar, Atulya; Sahoo, Manmath

    2016-01-01

    The book is a collection of high-quality peer-reviewed research papers presented in the first International Conference on Signal, Networks, Computing, and Systems (ICSNCS 2016) held at Jawaharlal Nehru University, New Delhi, India during February 25–27, 2016. The book is organized in to two volumes and primarily focuses on theory and applications in the broad areas of communication technology, computer science and information security. The book aims to bring together the latest scientific research works of academic scientists, professors, research scholars and students in the areas of signal, networks, computing and systems detailing the practical challenges encountered and the solutions adopted.

  19. New challenges to air/gas cleaning systems

    Energy Technology Data Exchange (ETDEWEB)

    Kovach, J.L. [NUCON International, Inc., Columbus, OH (United States)

    1997-08-01

    This paper discusses the need for changes in the design and manufacturing of air and gas cleaning systems to meet waste management and site remediation requirements. Current design and manufacturing practices are primarily directed toward evaluating operational problems with existing systems in nuclear reactor facilities. However, nuclear waste management needs have developed which are much broader in scope and have different processing conditions. Numerous examples of air cleaning needs for waste management activities are provided; the major differences from operating facility needs are the requirement for continuous effluent treatment under widely different processing conditions. Related regulatory issues are also discussed briefly. 1 ref.

  20. Online reputation systems: The effects of feedback comments and reactions on building and rebuilding trust in online auctions

    NARCIS (Netherlands)

    Utz, S.; Matzat, U.; Snijders, C.

    2009-01-01

    Previous research on reputation systems primarily focused on their trust-building function. The present research addresses their trust-rebuilding function-specifically, the role of the short text comments given in reaction to negative feedback. Rebuilding trust is often necessary because on-line

  1. Influence of various alternative bedding materials on pododermatitis in broilers raised in a built-up litter system

    Science.gov (United States)

    Broilers in the United States are frequently raised on built-up litter systems, primarily bedded with pine wood chips (shavings) or sawdust. There is continuing interest in alternative bedding materials as pine products are often in short supply and prices rise accordingly. Alternative bedding mat...

  2. Secure ADS-B: Towards Airborne Communications Security in the Federal Aviation Administration’s Next Generation Air Transportation System

    Science.gov (United States)

    2014-03-01

    76 5.2 Impact . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 78 5.3 Recommendations for Future Work...Global Positioning System ICAO International Civil Aviation Organization IFF Identification Friend or Foe IFR Instrument Flight Rules IMO...Instrument Flight Rules ( IFR ). Under VFR, typically used by General Aviation (GA) aircraft operating under 18,000 feet, the pilot is primarily responsible

  3. Bitcoin System

    Directory of Open Access Journals (Sweden)

    Jan Lánský

    2017-06-01

    Full Text Available Cryptocurrency systems are purely digital and decentralized systems that use cryptographic principles to confirm transactions. Bitcoin is the first and also the most widespread cryptocurrency. The aim of this article is to introduce Bitcoin system using a language understandable also to readers without computer science education. This article captures the Bitcoin system from three perspectives: internal structure, network and users. Emphasis is placed on brief and clear definitions (system components and their mutual relationships. A new system view of the stated terms constitutes author’s own contribution.

  4. JOSHUA system

    International Nuclear Information System (INIS)

    Honeck, H.C.

    1975-04-01

    A major computational system called JOSHUA has been under development at the Savannah River Laboratory since 1968. The JOSHUA System has two major parts: the Operating System and the Application System. The Operating System has been in production use since 1970 and provides data management, terminal, and job execution facilities. The Application System uses these facilities in solving problems in reactor physics and engineering. Features of the Application System are the two-dimensional lattice physics and three-dimensional transient reactor physics capabilities, which have been in use since 1971 and 1974, respectively. The capabilities of the JOSHUA System are summarized, and statistics on size, use, and development effort are provided. (U.S.)

  5. Systems thinking.

    Science.gov (United States)

    Cabrera, Derek; Colosi, Laura; Lobdell, Claire

    2008-08-01

    Evaluation is one of many fields where "systems thinking" is popular and is said to hold great promise. However, there is disagreement about what constitutes systems thinking. Its meaning is ambiguous, and systems scholars have made diverse and divergent attempts to describe it. Alternative origins include: von Bertalanffy, Aristotle, Lao Tsu or multiple aperiodic "waves." Some scholars describe it as synonymous with systems sciences (i.e., nonlinear dynamics, complexity, chaos). Others view it as taxonomy-a laundry list of systems approaches. Within so much noise, it is often difficult for evaluators to find the systems thinking signal. Recent work in systems thinking describes it as an emergent property of four simple conceptual patterns (rules). For an evaluator to become a "systems thinker", he or she need not spend years learning many methods or nonlinear sciences. Instead, with some practice, one can learn to apply these four simple rules to existing evaluation knowledge with transformative results.

  6. Cognitive Systems

    DEFF Research Database (Denmark)

    The tutorial will discuss the definition of cognitive systems as the possibilities to extend the current systems engineering paradigm in order to perceive, learn, reason and interact robustly in open-ended changing environments. I will also address cognitive systems in a historical perspective...... to be modeled within a limited set of predefined specifications. There will inevitably be a need for robust decisions and behaviors in novel situations that include handling of conflicts and ambiguities based on the capability and knowledge of the artificial cognitive system. Further, there is a need...... in cognitive systems include e.g. personalized information systems, sensor network systems, social dynamics system and Web2.0, and cognitive components analysis. I will use example from our own research and link to other research activities....

  7. Crystal Systems.

    Science.gov (United States)

    Schomaker, Verner; Lingafelter, E. C.

    1985-01-01

    Discusses characteristics of crystal systems, comparing (in table format) crystal systems with lattice types, number of restrictions, nature of the restrictions, and other lattices that can accidently show the same metrical symmetry. (JN)

  8. Filter systems

    International Nuclear Information System (INIS)

    Vanin, V.R.

    1990-01-01

    The multidetector systems for high resolution gamma spectroscopy are presented. The observable parameters for identifying nuclides produced simultaneously in the reaction are analysed discussing the efficiency of filter systems. (M.C.K.)

  9. Expert systems

    International Nuclear Information System (INIS)

    Haldy, P.A.

    1988-01-01

    The definitions of the terms 'artificial intelligence' and 'expert systems', the methodology, areas of employment and limits of expert systems are discussed. The operation of an expert system is described, especially the presentation and organization of knowledge as well as interference and control. Methods and tools for expert system development are presented and their application in nuclear energy are briefly addressed. 7 figs., 2 tabs., 6 refs

  10. Expert System

    DEFF Research Database (Denmark)

    Hildebrandt, Thomas Troels; Cattani, Gian Luca

    2016-01-01

    An expert system is a computer system for inferring knowledge from a knowledge base, typically by using a set of inference rules. When the concept of expert systems was introduced at Stanford University in the early 1970s, the knowledge base was an unstructured set of facts. Today the knowledge b...... for the application of expert systems, but also raises issues regarding privacy and legal liability....

  11. Texaco gasification power systems for clean energy

    International Nuclear Information System (INIS)

    Quintana, M.E.; Thone, P.W.

    1991-01-01

    The Texaco Gasification Power Systems integrate Texaco's proprietary gasification technology with proven power generation and energy recovery schemes for efficient and environmentally superior fuel utilization. Texaco's commercial experience on gasification spans a period of over 40 years. During this time, the Texaco Gasification Process has been used primarily to manufacture synthesis gas for chemical applications in one hundred commercial installations worldwide. Power generation using the Texaco Gasification Power Systems (TGPS) concept has been successfully demonstrated at the Texaco-sponsored Cool Water Coal Gasification Program in California. The environmental superiority of this technology was demonstrated by the consistent performance of Cool Water in exceeding the strict emission standards of the state of California. Currently, several TGPS projects are under evaluation worldwide for power generation in the range of 90MW to 1300MW

  12. RIMS [Records Inventory Management System] Handbook

    International Nuclear Information System (INIS)

    1989-03-01

    The Records Inventory Management System (RIMS) is a computer library of abstracted documents relating to low-level radioactive waste. The documents are of interest to state governments, regional compacts, and the Department of Energy, especially as they relate to the Low-Level Radioactive Waste Policy Act requiring states or compacts of states to establish and operate waste disposal facilities. RIMS documents are primarily regulatory, policy, or technical documents, published by the various states and compacts of the United States; however, RIMS contains key international publications as well. The system has two sections: a document retrieval section and a document update section. The RIMS mainframe can be accessed through a PC or modem. Also, each state and compact may request a PC version of RIMS, which allows a user to enter documents off line and then upload the documents to the mainframe data base

  13. Control and Estimation of Distributed Parameter Systems

    CERN Document Server

    Kappel, F; Kunisch, K

    1998-01-01

    Consisting of 23 refereed contributions, this volume offers a broad and diverse view of current research in control and estimation of partial differential equations. Topics addressed include, but are not limited to - control and stability of hyperbolic systems related to elasticity, linear and nonlinear; - control and identification of nonlinear parabolic systems; - exact and approximate controllability, and observability; - Pontryagin's maximum principle and dynamic programming in PDE; and - numerics pertinent to optimal and suboptimal control problems. This volume is primarily geared toward control theorists seeking information on the latest developments in their area of expertise. It may also serve as a stimulating reader to any researcher who wants to gain an impression of activities at the forefront of a vigorously expanding area in applied mathematics.

  14. Fuels processing for transportation fuel cell systems

    Science.gov (United States)

    Kumar, R.; Ahmed, S.

    Fuel cells primarily use hydrogen as the fuel. This hydrogen must be produced from other fuels such as natural gas or methanol. The fuel processor requirements are affected by the fuel to be converted, the type of fuel cell to be supplied, and the fuel cell application. The conventional fuel processing technology has been reexamined to determine how it must be adapted for use in demanding applications such as transportation. The two major fuel conversion processes are steam reforming and partial oxidation reforming. The former is established practice for stationary applications; the latter offers certain advantages for mobile systems and is presently in various stages of development. This paper discusses these fuel processing technologies and the more recent developments for fuel cell systems used in transportation. The need for new materials in fuels processing, particularly in the area of reforming catalysis and hydrogen purification, is discussed.

  15. Reactor coolant pressure boundary leakage detection system

    International Nuclear Information System (INIS)

    Dissing, E.; Svansson, L.

    1980-01-01

    This study deals with a system for monitoring the leakage of reactor coolant. This system is based primarily on the detection of the 13 N content in the containment atmosphere. 13 N is produced from the oxygen of the reactor water via the recoil proton nuclear process Hl+016/yields/ 13 N+ 4 He. The generation is therefore independent of fuel element leakage and of the corrosion product content in the water. It is solely related to the neutron flux level in the reactor core. Typical figures for the equilibrium 13 N concentration in the containment atmosphere following a 4 kg/minute coolant leakage are 5 kBq m/sup -3/ and 7 kBq m/sup -3/ for BWR and PWR respectively. These levels are readily measured with a 10 liter Ge(Li) flow detector assembly operated at elevated pressure. 8 refs

  16. Reactor coolant pressure boundary leakage detection system

    International Nuclear Information System (INIS)

    Dissing, E.; Svansson, L.

    1980-01-01

    This study deals with a system for monitoring the leakage of reactor coolant. This system is based primarily on the detection of the N13 content in the containment atmosphere. N13 is produced from the oxygen of the reactor water via the recoil proton nuclear process Hl+016/yields/Nl3+He4. The generation is therefore independent of fuel element leakage and of the corrosion product content in the water. It is solely related to the neutron flux level in the reactor core. Typical figures for the equilibrium N13 concentration in the containment atmosphere following a 4 kg/minute coolant leakage are 5 kBq m/sup -3/ and 7 kBq m/sup -3/ for BWR and PWR respectively. These levels are readily measured with a 10 liter Ge(Li) flow detector assembly operated at elevated pressure. 8 refs

  17. Reactor coolant pressure boundary leakage detection system

    International Nuclear Information System (INIS)

    Dissing, E.; Svansson, L.

    1979-08-01

    The present paper deals with a system for monitoring the leakage of reactor coolant. This system is based primarily on the detection of the N13 content in the containment atmosphere. N13 is produced from the oxygen of the reactor water via the recoil proton nuclear process H1+016 → N13+He4. The generation is therefore independent of fuel element leakage and of the corrosion product content in the water. It is solely related to the neutron flux level in the reactor core. Typical figures for the equilibrium N13 concentration in the containment atmosphere following a 4 kg/minute coolant leakage are 5 kBq m -3 and 7 kBq m -3 for BWR and PWR respectively. These levels are readily measured with a 10 liter Ge (Li) flow detector assembly operated at elevated pressure. (Auth.)

  18. Retrofitting Systems

    DEFF Research Database (Denmark)

    Rose, Jørgen

    1997-01-01

    This report gives an overview of the different retrofitting possibilities that are available today. The report looks at both external and internal systems for external wall constructions, roof constructions, floor constructions and foundations. All systems are described in detail in respect to use...... and methods, and the efficiency of the different systems are discussed....

  19. Power management for energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Gybel Hovgaard, T.

    2013-02-15

    In this thesis, we consider the control of two different industrial applications that belong at either end of the electricity grid; a power consumer in the form of a commercial refrigeration system, and wind turbines for power production. Our primary studies deal with economic model predictive control of a commercial multi-zone refrigeration system, consisting of several cooling units that share a common compressor, and is used to cool multiple areas or rooms, e.g., in supermarkets. For control of the commercial refrigeration application as well as the wind turbine application, we propose an economic optimizing model predictive controller, economic MPC. Our investigations are primarily concerned with: 1) modeling of the applications to suit the chosen control framework; 2) formulating the MPC controller laws to overcome challenges introduced by the industrial applications, and defining economic objectives that reect the real physics of the systems as well as our control objectives; 3) solving the involved, non-trivial optimization problems eciently in real-time; 4) demonstrating the feasibility and potential of the proposed methods by extensive simulation and comparison with existing control methods and evaluation of data from systems in actual operation. We demonstrate, i.a., substantial cost savings, on the order of 30 %, compared to a standard thermostat-based supermarket refrigeration system and show how our methods exhibit sophisticated demand response to real-time variations in electricity prices. Violations of the temperature ranges can be kept at a very low frequency of occurrence inspite of the presence of uncertainty. For the power output from wind turbines, ramp rates, as low a 3 % of the rated power per minute, can be effectively ensured with the use of energy storage and we show how the active use of rotor inertia as an additional energy storage can reduce the needed storage capacity by up to 30 % without reducing the power output. (Author)

  20. Multifunction system

    International Nuclear Information System (INIS)

    Wauthier, J.; Fiori, R.

    1990-01-01

    The development, the characteristics and the applications of a multifunction system are presented. The system is used on the RBES laboratory pipes, at Marcoule. The system was developed in order to allow, without time loss, the modification of the circuit function by replacing only one component. The following elements form the multifunction system: a fixed base, which is part of the tube, a removable piece, which is inserted into the base, a cover plate and its locking system. The material, chosen among commercial trade marks, required small modifications in order to be used in the circuit [fr

  1. Operating systems

    CERN Document Server

    Tsichritzis, Dionysios C; Rheinboldt, Werner

    1974-01-01

    Operating Systems deals with the fundamental concepts and principles that govern the behavior of operating systems. Many issues regarding the structure of operating systems, including the problems of managing processes, processors, and memory, are examined. Various aspects of operating systems are also discussed, from input-output and files to security, protection, reliability, design methods, performance evaluation, and implementation methods.Comprised of 10 chapters, this volume begins with an overview of what constitutes an operating system, followed by a discussion on the definition and pr

  2. Building a Global Earth Observation System of Systems (GEOSS) and Its Interoperability Challenges

    Science.gov (United States)

    Ryan, B. J.

    2015-12-01

    Launched in 2005 by industrialized nations, the Group on Earth Observations (GEO) began building the Global Earth Observation System of Systems (GEOSS). Consisting of both a policy framework, and an information infrastructure, GEOSS, was intended to link and/or integrate the multitude of Earth observation systems, primarily operated by its Member Countries and Participating Organizations, so that users could more readily benefit from global information assets for a number of society's key environmental issues. It was recognized that having ready access to observations from multiple systems was a prerequisite for both environmental decision-making, as well as economic development. From the very start, it was also recognized that the shear complexity of the Earth's system cannot be captured by any single observation system, and that a federated, interoperable approach was necessary. While this international effort has met with much success, primarily in advancing broad, open data policies and practices, challenges remain. In 2014 (Geneva, Switzerland) and 2015 (Mexico City, Mexico), Ministers from GEO's Member Countries, including the European Commission, came together to assess progress made during the first decade (2005 to 2015), and approve implementation strategies and mechanisms for the second decade (2016 to 2025), respectively. The approved implementation strategies and mechanisms are intended to advance GEOSS development thereby facilitating the increased uptake of Earth observations for informed decision-making. Clearly there are interoperability challenges that are technological in nature, and several will be discussed in this presentation. There are, however, interoperability challenges that can be better characterized as economic, governmental and/or political in nature, and these will be discussed as well. With the emergence of the Sustainable Development Goals (SDGs), the World Conference on Disaster Risk Reduction (WCDRR), and the United Nations

  3. Photovoltaic generating systems in rural schools in Neuquen Province, Argentina

    Energy Technology Data Exchange (ETDEWEB)

    Lawand, T.A.; Campbell, J. [Brace Research Institute, Quebec (Canada)

    1997-12-01

    During the period 1994-95, solar photovoltaic systems were installed at a number of schools in Neuquen Province, Argentina, by the Provincial electric utility, Ente Provincial de Energia del Neuquen. This was undertaken with funds provided by the Inter-American Development Bank. In all, there are 12 schools that have had photovoltaic generating systems installed. These generating systems are designed to provide electricity for the basic needs at the schools: primarily for lighting, and to operate small electrical appliances such as communication radios, televisions, VCR`s, AM/FM and short-wave radios. They do not provide enough energy to operate large consumption appliances such as washing machines, microwaves, refrigerators, power tools, etc. The program of provision of PV systems was supplemented with training on simple systems for cooking food or drying fruit, etc. These techniques are primarily intended for demonstration at the schools thus serving an educational role with the hope that they will be transmitted in time to the families of the students where the need is manifested the most.

  4. Smile (System/Machine-Independent Local Environment)

    Energy Technology Data Exchange (ETDEWEB)

    Fletcher, J.G.

    1988-04-01

    This document defines the characteristics of Smile, a System/machine-independent local environment. This environment consists primarily of a number of primitives (types, macros, procedure calls, and variables) that a program may use; these primitives provide facilities, such as memory allocation, timing, tasking and synchronization beyond those typically provided by a programming language. The intent is that a program will be portable from system to system and from machine to machine if it relies only on the portable aspects of its programming language and on the Smile primitives. For this to be so, Smile itself must be implemented on each system and machine, most likely using non-portable constructions; that is, while the environment provided by Smile is intended to be portable, the implementation of Smile is not necessarily so. In order to make the implementation of Smile as easy as possible and thereby expedite the porting of programs to a new system or a new machine, Smile has been defined to provide a minimal portable environment; that is, simple primitives are defined, out of which more complex facilities may be constructed using portable procedures. The implementation of Smile can be as any of the following: the underlying software environment for the operating system of an otherwise {open_quotes}bare{close_quotes} machine, a {open_quotes}guest{close_quotes} system environment built upon a preexisting operating system, an environment within a {open_quotes}user{close_quotes} process run by an operating system, or a single environment for an entire machine, encompassing both system and {open_quotes}user{close_quotes} processes. In the first three of these cases the tasks provided by Smile are {open_quotes}lightweight processes{close_quotes} multiplexed within preexisting processes or the system, while in the last case they also include the system processes themselves.

  5. Utility guide to advanced UT systems for PSI and ISI

    International Nuclear Information System (INIS)

    Anon.

    1987-01-01

    The number of automated UT inspection systems and techniques, currently in the marketplace or being developed, has grown in recent years to the point where a utility engineer reviewing this field is faced with a major task in trying to decide what inspection technique and system will meet his inspection requirements. Recognizing the utility engineer's problem, EPRI initiated this project to produce a utility engineer's guide to advanced, automated UT systems. Of principal concern are those that have been recently introduced, and designed for problem areas such as BWR piping. Older automated scanning systems, used primarily for pressure vessel inspection, are not being ignored, but are not covered here. Costs, benefits and inspection time are addressed for several systems in this report

  6. Web-Based Group Decision Support System: an Economic Application

    Directory of Open Access Journals (Sweden)

    Ion ISTUDOR

    2010-01-01

    Full Text Available Decision Support Systems (DSS form a specific class of computerized information systems that support business and managerial decision-making activities. Making the right decision in business primarily depends on the quality of data. It also depends on the ability to analyze the data with a view to identifying trends that can suggest solutions and strategies. A “cooperative” decision support system means the data are collected, analyzed and then provided to a human agent who can help the system to revise or refine the data. It means that both a human component and computer component work together to come up with the best solution. This paper describes the usage of a software product (Vanguard System to a specific economic application (evaluating the financial risk assuming that the rate of the economic profitability can be under the value of the interest rate.

  7. Applications of polymeric nanocapsules in field of drug delivery systems.

    Science.gov (United States)

    Rong, Xinyu; Xie, Yinghua; Hao, Xiaomei; Chen, Tao; Wang, Yingming; Liu, Yuanyuan

    2011-09-01

    Drug-loaded polymeric nanocapsules have exhibited potential applications in the field of drug delivery systems in recent years. This article entails the biodegradable polymers generally used for preparing nanocapsules, which include both natural polymers and synthetic polymers. Furthermore, the article presents a general review of the different preparation methods: nanoprecipitation method, emulsion-diffusion method, double emulsification method, emulsion-coacervation method, layer-by-layer assembly method. In addition, the analysis methods of nanocapsule characteristics, such as mean size, morphology, surface characteristics, shell thickness, encapsulation efficiency, active substance release, dispersion stability, are mentioned. Also, the applications of nanocapsules as carriers for use in drug delivery systems are reviewed, which primarily involve targeting drug delivery, controlled/sustained release drug delivery systems, transdermal drug delivery systems and improving stability and bioavailability of drugs. Nanocapsules, prepared with different biodegradable polymers, have received more and more attention and have been regarded as one of the most promising drug delivery systems.

  8. Systems integration.

    Science.gov (United States)

    Siemieniuch, C E; Sinclair, M A

    2006-01-01

    The paper presents a view of systems integration, from an ergonomics/human factors perspective, emphasising the process of systems integration as is carried out by humans. The first section discusses some of the fundamental issues in systems integration, such as the significance of systems boundaries, systems lifecycle and systems entropy, issues arising from complexity, the implications of systems immortality, and so on. The next section outlines various generic processes for executing systems integration, to act as guides for practitioners. These address both the design of the system to be integrated and the preparation of the wider system in which the integration will occur. Then the next section outlines some of the human-specific issues that would need to be addressed in such processes; for example, indeterminacy and incompleteness, the prediction of human reliability, workload issues, extended situation awareness, and knowledge lifecycle management. For all of these, suggestions and further readings are proposed. Finally, the conclusions section reiterates in condensed form the major issues arising from the above.

  9. Further development of the ZEUS Expert System: Computer science foundations of design

    International Nuclear Information System (INIS)

    Flasinski, M.

    1994-03-01

    The prototype version of the ZEUS Expert System, ZEXP, was diagnosing selected aspects of DAQ System during ZEUS running in 1993. In November 1993 ZEUS decided to extend its scope in order to cover all crucial aspects of operating the ZEUS detector (Run Control, Slow Control, Data Acquisition performance and Data Quality Monitoring). The paper summarizes fundamental assumptions concerning the design of the final version of the ZEUS Expert System, ZEX. Although the theoretical background material relates primarily to ZEX, its elements can be used for constructing other expert systems for HEP experiments. (orig.)

  10. Ternary systems

    International Nuclear Information System (INIS)

    Kagan, D.N.; Hubberstey, P.; Barker, M.G.

    1985-01-01

    The paper reviews the experimental and theoretical studies carried out on multicomponent alkali metal systems. Solid-liquid phase equilibria studies are mainly concerned with the systems Na-K-Rb and Na-K-Cs, and data on the liquidus temperatures in these systems are presented. The thermodynamic properties of the ternary Na-K-Cs eutectic system have been determined experimentally, and the enthalpy, heat capacity and excess functions of the alloy are given. An analysis of calculational methods used in determining thermodynamic functions of ternary liquid metals systems is described. Finally, data are tabulated for the density, compressibility, saturated vapour pressure, viscosity and thermal conductivity of the ternary Na-K-Cs eutectic system. (UK)

  11. System Dynamics Modeling for the Resilience in Nuclear Power Plants

    International Nuclear Information System (INIS)

    Florah, Kamanj; Kim, Jonghyun

    2013-01-01

    This paper aims to model and evaluate emergency operation system (EOS) resilience using the System Dynamics. System Dynamics is the study of causal interactions between elements of a complex system. This paper identifies the EOS resilience attributes and their interactions by constructing a causal loop diagram. Then, the interactions are quantified based on literature review and simulated to analyze resilience dynamics. This paper describes the use of system dynamics to improve understanding of the resilience dynamics of complex systems such as emergency operation systems. This paper takes into account two aspects; the strength of resilience attributes interactions and the quantification of dynamic behaviour of resilience over time. This model can be applied to review NPP safety in terms of the resilience level and organization. Simulation results can give managers insights to support their decisions in safety management. A nuclear power plant (NPP) is classified as a safety critical organization whose safety objective is to control hazards that can cause significant harm to the environment, public, or personnel. There has been a significant improvement of safety designs as well as risk analysis tools and methods applied in nuclear power plants over the last decade. Conventional safety analysis methods such as PSA have several limitations they primarily focus on technical dimension, the analysis are linear and sequential, they are dominated by static models, they do not take a systemic view into account, and they focus primarily on why accidents happen and not how success is achieved. Hence new approaches to risk analysis for NPPs are needed to complement the conventional approaches. Resilience is the intrinsic ability of a system to adjust to its functioning prior to, during, or following changes and disturbances, so that it can sustain required operations under both expected and unexpected conditions. An EOS in a NPP refers to a system consisting of personnel

  12. System Dynamics Modeling for the Resilience in Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Florah, Kamanj; Kim, Jonghyun [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

    2013-10-15

    This paper aims to model and evaluate emergency operation system (EOS) resilience using the System Dynamics. System Dynamics is the study of causal interactions between elements of a complex system. This paper identifies the EOS resilience attributes and their interactions by constructing a causal loop diagram. Then, the interactions are quantified based on literature review and simulated to analyze resilience dynamics. This paper describes the use of system dynamics to improve understanding of the resilience dynamics of complex systems such as emergency operation systems. This paper takes into account two aspects; the strength of resilience attributes interactions and the quantification of dynamic behaviour of resilience over time. This model can be applied to review NPP safety in terms of the resilience level and organization. Simulation results can give managers insights to support their decisions in safety management. A nuclear power plant (NPP) is classified as a safety critical organization whose safety objective is to control hazards that can cause significant harm to the environment, public, or personnel. There has been a significant improvement of safety designs as well as risk analysis tools and methods applied in nuclear power plants over the last decade. Conventional safety analysis methods such as PSA have several limitations they primarily focus on technical dimension, the analysis are linear and sequential, they are dominated by static models, they do not take a systemic view into account, and they focus primarily on why accidents happen and not how success is achieved. Hence new approaches to risk analysis for NPPs are needed to complement the conventional approaches. Resilience is the intrinsic ability of a system to adjust to its functioning prior to, during, or following changes and disturbances, so that it can sustain required operations under both expected and unexpected conditions. An EOS in a NPP refers to a system consisting of personnel

  13. Recommender systems

    CERN Document Server

    Kembellec, Gérald; Saleh, Imad

    2014-01-01

    Acclaimed by various content platforms (books, music, movies) and auction sites online, recommendation systems are key elements of digital strategies. If development was originally intended for the performance of information systems, the issues are now massively moved on logical optimization of the customer relationship, with the main objective to maximize potential sales. On the transdisciplinary approach, engines and recommender systems brings together contributions linking information science and communications, marketing, sociology, mathematics and computing. It deals with the understan

  14. Material Systems

    DEFF Research Database (Denmark)

    Jensen, Mads Brath; Mortensen, Henrik Rubæk; Mullins, Michael

    2009-01-01

    This paper describes and reflects upon the results of an investigative project which explores the setting up of a material system - a parametric and generative assembly consisting of and taking into consideration material properties, manufacturing constraints and geometric behavior. The project...... approaches the subject through the construction of a logic-driven system aiming to explore the possibilities of a material system that fulfills spatial, structural and performative requirements concurrently and how these are negotiated in situations where they might be conflicting....

  15. Systems Engineering

    OpenAIRE

    Vaughan, William W.

    2016-01-01

    The term “systems engineering” when entered into the Google search page, produces a significant number of results, evidence that systems engineering is recognized as being important for the success of essentially all products. Since most readers of this item will be rather well versed in documents concerning systems engineering, I have elected to share some of the points made on this subject in a document developed by the European Cooperation for Space Standardization (ECSS), a component of t...

  16. Current status and perspective of heavy ion beam therapy for patients with pelvic recurrence after primarily resected rectal cancer

    International Nuclear Information System (INIS)

    Yamada, Shigeru; Yanagi, Tsuyoshi; Hara, Ryusuke; Yasuda, Shigeo; Kato, Hirotoshi; Kamada, Tadashi; Tsujii, Hirohiko

    2008-01-01

    This review describes the clinical features of recurrent rectal cancer (RC) and therapeutic properties of heavy ion beam (HIB, here, carbon ion beam) and outcome of its clinical trials with use of Heavy Ion Medical Accelerator in Chiba (HIMAC). The authors at first explain the statistics in Japan, clinical procession and therapy involving surgery, of primary and recurrent colorectal cancers. Then mentioned are characteristics of HIB for its class used for medical purpose, physical and biological properties. By February 2008, HIBs generated by HIMAC have been used to 3,819 patients with malignant diseases difficult for treatment with ordinary means hitherto like tumors of head and neck, brain, lung, esophagus, liver cells, prostate, uterine and bone/soft tissues. For patients with localized recurrent RC after surgery, as HIB therapy is promising for its high LET, phase I/II trial of HIB started in 2001 where 38 cases were enrolled, which defined a optimal dose of 73.6 GyE in 2004 with 3-year local control and survival of 81.8% and 75.0%, respectively, with scarce adverse effects. The phase II trial with the dose is now under progress as a pioneer medicare where, at present, 5-year local control of 93% and survival 57% are shown with scarce adverse event in 61 cases, which is thought to be better than any other radiotherapy outcome. Efforts are still being made for aiming wider application of HIB for recurrent RC like development of the spacer between the lesion and normal digestive tract to avoid the radiation exposure of the latter. (R.T.)

  17. Accumulation of a Polyhydroxyalkanoate Containing Primarily 3-Hydroxydecanoate from Simple Carbohydrate Substrates by Pseudomonas sp. Strain NCIMB 40135.

    Science.gov (United States)

    Haywood, G W; Anderson, A J; Ewing, D F; Dawes, E A

    1990-11-01

    A number of Pseudomonas species have been identified which accumulate a polyhydroxyalkanoate containing mainly 3-hydroxydecanoate monomers from sodium gluconate as the sole carbon source. One of these, Pseudomonas sp. strain NCIMB 40135, was further investigated and shown to accumulate such a polyhydroxyalkanoate from a wide range of carbon sources (C(2) to C(6)); however, when supplied with octanoic acid it produced a polyhydroxyalkanoate containing mainly 3-hydroxyoctanoate monomers. Polymer synthesis occurred in batch culture after cessation of growth due to exhaustion of nitrogen. In continuous culture under nitrogen limitation up to 16.9% (wt/wt) polyhydroxyalkanoate was synthesized from glucose as the carbon source. The monomer units are mainly of the R-(-) configuration. Nuclear magnetic resonance studies confirmed the composition of the polymer. Differential scanning calorimetry suggested that the solvent-extracted polymer contained a significant proportion of crystalline material. The weight-average molecular weight of the polymer from glucose-grown cells was 143,000.

  18. Accumulation of a Polyhydroxyalkanoate Containing Primarily 3-Hydroxydecanoate from Simple Carbohydrate Substrates by Pseudomonas sp. Strain NCIMB 40135

    OpenAIRE

    Haywood, Geoffrey W.; Anderson, Alistair J.; Ewing, David F.; Dawes, Edwin A.

    1990-01-01

    A number of Pseudomonas species have been identified which accumulate a polyhydroxyalkanoate containing mainly 3-hydroxydecanoate monomers from sodium gluconate as the sole carbon source. One of these, Pseudomonas sp. strain NCIMB 40135, was further investigated and shown to accumulate such a polyhydroxyalkanoate from a wide range of carbon sources (C2 to C6); however, when supplied with octanoic acid it produced a polyhydroxyalkanoate containing mainly 3-hydroxyoctanoate monomers. Polymer sy...

  19. Synthetic virus-like particles target dendritic cell lipid rafts for rapid endocytosis primarily but not exclusively by macropinocytosis.

    Directory of Open Access Journals (Sweden)

    Rajni Sharma

    Full Text Available DC employ several endocytic routes for processing antigens, driving forward adaptive immunity. Recent advances in synthetic biology have created small (20-30 nm virus-like particles based on lipopeptides containing a virus-derived coiled coil sequence coupled to synthetic B- and T-cell epitope mimetics. These self-assembling SVLP efficiently induce adaptive immunity without requirement for adjuvant. We hypothesized that the characteristics of DC interaction with SVLP would elaborate on the roles of cell membrane and intracellular compartments in the handling of a virus-like entity known for its efficacy as a vaccine. DC rapidly bind SVLP within min, co-localised with CTB and CD9, but not caveolin-1. In contrast, internalisation is a relatively slow process, delivering SVLP into the cell periphery where they are maintained for a number of hrs in association with microtubules. Although there is early association with clathrin, this is no longer seen after 10 min. Association with EEA-1(+ early endosomes is also early, but proteolytic processing appears slow, the SVLP-vesicles remaining peripheral. Association with transferrin occurs rarely, and only in the periphery, possibly signifying translocation of some SVLP for delivery to B-lymphocytes. Most SVLP co-localise with high molecular weight dextran. Uptake of both is impaired with mature DC, but there remains a residual uptake of SVLP. These results imply that DC use multiple endocytic routes for SVLP uptake, dominated by caveolin-independent, lipid raft-mediated macropinocytosis. With most SVLP-containing vesicles being retained in the periphery, not always interacting with early endosomes, this relates to slow proteolytic degradation and antigen retention by DC. The present characterization allows for a definition of how DC handle virus-like particles showing efficacious immunogenicity, elements valuable for novel vaccine design in the future.

  20. Mixed electrical-chemical synapses in adult rat hippocampus are primarily glutamatergic and coupled by connexin-36

    Directory of Open Access Journals (Sweden)

    Farid eHamzei-Sichani

    2012-05-01

    Full Text Available Dendrodendritic electrical signaling via gap junctions is now an accepted feature of neuronal communication in the mammalian brain, whereas axodendritic and axosomatic gap junctions have rarely been described. We present ultrastructural, immunocytochemical, and dye-coupling evidence for mixed (electrical/chemical synapses in adult rat hippocampus on both principal cells and interneurons. Thin-section electron microscopic images of small gap junction-like appositions were found at mossy fiber (MF terminals on thorny excrescences of CA3 pyramidal neurons (CA3pyr, apparently forming glutamatergic mixed synapses. Lucifer Yellow injected into four weakly-fixed CA3pyr was detected in MF axons that contacted the injected CA3pyr, supporting gap junction-mediated coupling between those two types of principal cells. Freeze-fracture replica immunogold-labeling revealed diverse sizes and morphologies of connexin36-containing gap junctions throughout hippocampus. Of 20 immunogold-labeled gap junctions, seven were large (328-1140 connexons, three of which were consistent with electrical synapses between interneurons; but nine were at axon terminal synapses, three of which were immediately adjacent to distinctive glutamate receptor-containing postsynaptic densities, forming mixed glutamatergic synapses. Four others were adjacent to small clusters of immunogold-labeled 10-nm E-face intramembrane particles, apparently representing extrasynaptic glutamate receptor particles. Gap junctions also were on spines in stratum lucidum, stratum oriens, dentate gyrus, and hilus, on both interneurons and unidentified neurons. In addition, one putative GABAergic mixed synapse was found in thin section images of a CA3pyr, but none found by immunogold-labeling were at GABAergic mixed synapses, suggesting their rarity. Cx36-containing gap junctions throughout hippocampus suggest the possibility of reciprocal modulation of electrical and chemical signals in diverse hippocampal neurons.

  1. Cost-Effectiveness Analysis of Various Pertussis Vaccination Strategies Primarily Aimed at Protecting Infants in the Netherlands

    NARCIS (Netherlands)

    Westra, Tjalke A.; de Vries, Robin; Tamminga, Johannes J.; Sauboin, Christophe J.; Postma, Maarten J.

    Background: Pertussis is a highly contagious respiratory disease. Despite a high rate of vaccine coverage through the Dutch national immunization program, the incidence of pertussis remains high in the Netherlands and the risk of infection continues. Because pertussis is most severe in unimmunized

  2. An inulin-type fructan enhances calcium absorption primarily via an effect on colonic absorption in humans

    Science.gov (United States)

    Calcium absorption efficiency and bone mineral mass are increased in adolescents who regularly consume inulin-type fructans (ITF). The mechanism of action in increasing absorption is unknown but may be related to increased colonic calcium absorption. We conducted a study in young adults designed to ...

  3. PRIMARILY RESULTS OF PHYTOPLANKTON DNA AND VARIATION TO ENVIRONMENTAL FACTORS IN DURRES`S BAY COASTAL WATERS (ALBANIA

    Directory of Open Access Journals (Sweden)

    Laura Gjyli

    2013-10-01

    Full Text Available After isolation of phytoplankton DNA in coastal waters of Durres Bay, Albania, quantification and analysis of quality were investigated with spectrophotometric analysis. Analysis of UV absorption by the nucleotides provides a simple and accurate estimation of the concentration of nucleic acids in a sample. This method is however limited by the quantity of DNA and the purity of the preparation. Also biotic environment factors as Chlorophyll a and abiotic environment factors as temperature, salinity, pH, dissolved oxygen, turbidity, nitrate, phosphate were investigated to assess DNA quantities in different environment conditions. The Chlorophyll a was studied also to access the level of trophy. The sample stations were: Golem Beach (GB, Channel of Plepa (ChP, Hekurudha Beach (HB, Ex-Fuel Quay in Marine Durres Harbour (EFQ, Water Channel of Durres City (WChDC and Currila Beach (CB. Samples are taken in one meter depth from the water surface. Water samples were collected monthly from April to October 2011. The most abundant stations with phytoplankton DNA are Channel of Plepa and Water Channel of Durres City. This confirms that there are spills of fresh waters, sewage or agricultural water spills, often discharge in coastal waters. Referring Mutliple Regression Analysis and single regression analysis, the association between phytoplankton DNA and environment factors was strong (R2 = 0.75. Basing in single correlation and statistically significance (p-value ≤ 0.05, the enviroment factors that correlated to phytoplankton DNA were pH, salinity and phosphate; explaining thus the variation of total phytoplankton in Durres Bay coastal waters.

  4. In Graves' disease, increased muscle tension and reduced elasticity of affected muscles is primarily caused by active muscle contraction

    NARCIS (Netherlands)

    H.J. Simonsz (Huib); G. Kommerell (Guntram)

    1989-01-01

    textabstractIn three patients with Graves' disease of recent onset, length-tension diagrams were made during surgery for squint under eyedrop anesthesia, while the other eye looked ahead, into the field of action, or out of the field of action of the muscle that was measured. The affected muscles

  5. Literature review Quasi-static and Dynamic pile load tests : Primarily report on non-static pile load tests

    NARCIS (Netherlands)

    Huy, N.Q.

    2010-01-01

    Pile testing, which plays an importance role in the field of deep foundation design, is performed by static and non-static methods to provide information about the following issues: (Poulos, 1998) - The ultimate capacity of a single pile. - The load-displacement behavior of a pile. - The performance

  6. Proliferating cells in psoriatic dermis are comprised primarily of T cells, endothelial cells, and factor XIIIa+ perivascular dendritic cells

    International Nuclear Information System (INIS)

    Morganroth, G.S.; Chan, L.S.; Weinstein, G.D.; Voorhees, J.J.; Cooper, K.D.

    1991-01-01

    Determination of the cell types proliferating in the dermis of patients with psoriasis should identify those cells experiencing activation or responding to growth factors in the psoriatic dermal milieu. Toward that end, sections of formalin-fixed biopsies obtained from 3H-deoxyuridine (3H-dU)-injected skin of eight psoriatic patients were immunostained, followed by autoradiography. Proliferating dermal cells exhibit silver grains from tritium emissions. The identity of the proliferating cells could then be determined by simultaneous visualization with antibodies specific for various cell types. UCHL1+ (CD45RO+) T cells (recall antigen-reactive helper T-cell subset) constituted 36.6 +/- 3.1% (mean +/- SEM, n = 6) of the proliferating dermal cells in involved skin, whereas Leu 18+ (CD45RA+) T cells (recall antigen naive T-cell subsets) comprised only 8.7 +/- 1.5% (n = 6). The Factor XIIIa+ dermal perivascular dendritic cell subset (24.9 +/- 1.5% of proliferating dermal cells, n = 6) and Factor VIII+ endothelial cells represented the two other major proliferating populations in lesional psoriatic dermis. Differentiated tissue macrophages, identified by phase microscopy as melanophages or by immunostaining with antibodies to Leu M1 (CD15) or myeloid histiocyte antigen, comprised less than 5% of the proliferating population in either skin type. In addition to calculating the relative proportions of these cells to each other as percent, we also determined the density of cells, in cells/mm2 of tissue. The density of proliferating cells within these populations was increased in involved versus uninvolved skin: UCHL1+, 9.0 +/- 1.7 cells/mm2 versus 1.8 +/- 0.6 cells/mm2, p less than 0.01; Factor XIIIa+, 6.0 +/- 0.7 cells/mm2 versus 1.5 +/- 0.5 cells/mm2, p less than 0.01; Factor VIII+, 5.5 +/- 1.4 cells/mm2 versus 0.0 cells/mm2, p less than 0.05

  7. The antibody response against human and chimeric anti-TNF therapeutic antibodies primarily targets the TNF binding region

    NARCIS (Netherlands)

    van Schie, K. A.; Hart, M. H.; de Groot, E. R.; Kruithof, S.; Aarden, L. A.; Wolbink, G. J.; Rispens, T.

    2015-01-01

    In a subset of patients, anti tumour necrosis factor (TNF) therapeutic antibodies are immunogenic, resulting in the formation of antidrug antibodies (ADAs). Neutralising ADAs compete with TNF for its binding site and reduces the effective serum concentration, causing clinical non-response. It is

  8. Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents

    DEFF Research Database (Denmark)

    Perry, Rachel J; Cardone, Rebecca L; Petersen, Max C

    2016-01-01

    Imeglimin is a promising new oral antihyperglycemic agent that has been studied in clinical trials as a possible monotherapy or add-on therapy to lower fasting plasma glucose and improve hemoglobin A1c (1-3, 9). Imeglimin was shown to improve both fasting and postprandial glycemia and to increase...

  9. Primarily Proximal Jejunal Stone Causing Enterolith Ileus in a Patient without Evidence of Cholecystoenteric Fistula or Jejunal Diverticulosis

    Directory of Open Access Journals (Sweden)

    Houssam Khodor Abtar

    2016-01-01

    Full Text Available Stone formation within the intestinal lumen is called enterolith. This stone can encroach into the lumen causing obstruction and surgical emergency. Jejunal obstruction by an enterolith is a very rare entity and often missed preoperatively. To our knowledge, most cases of jejunal obstruction, secondary to stone, were associated with biliary disease (cholecystoenteric fistula, bezoar, jejunal diverticulosis, or foreign body. Hereby we present a rare case report of small bowel obstruction in an elderly man who was diagnosed lately to have primary proximal jejunal obstruction by an enterolith without evidence of a cholecystoenteric fistula or jejunal diverticulosis. This patient underwent laparotomy, enterotomy with stone extraction, and subsequent primary repair of the bowel.

  10. Primarily Proximal Jejunal Stone Causing Enterolith Ileus in a Patient without Evidence of Cholecystoenteric Fistula or Jejunal Diverticulosis.

    Science.gov (United States)

    Abtar, Houssam Khodor; Mneimneh, Mostapha; Hammoud, Mazen M; Zaaroura, Ahmed; Papas, Yasmina S

    2016-01-01

    Stone formation within the intestinal lumen is called enterolith. This stone can encroach into the lumen causing obstruction and surgical emergency. Jejunal obstruction by an enterolith is a very rare entity and often missed preoperatively. To our knowledge, most cases of jejunal obstruction, secondary to stone, were associated with biliary disease (cholecystoenteric fistula), bezoar, jejunal diverticulosis, or foreign body. Hereby we present a rare case report of small bowel obstruction in an elderly man who was diagnosed lately to have primary proximal jejunal obstruction by an enterolith without evidence of a cholecystoenteric fistula or jejunal diverticulosis. This patient underwent laparotomy, enterotomy with stone extraction, and subsequent primary repair of the bowel.

  11. Biological half-life of bromide in the rat depends primarily on the magnitude of sodium intake

    Czech Academy of Sciences Publication Activity Database

    Pavelka, Stanislav; Babický, Arnošt; Vobecký, Miloslav

    2005-01-01

    Roč. 54, č. 6 (2005), s. 639-644 ISSN 0862-8408 Institutional research plan: CEZ:AV0Z50110509 Keywords : biological half-life * bromide * sodium Subject RIV: ED - Physiology Impact factor: 1.806, year: 2005

  12. Synthetic Virus-Like Particles Target Dendritic Cell Lipid Rafts for Rapid Endocytosis Primarily but Not Exclusively by Macropinocytosis

    Science.gov (United States)

    Sharma, Rajni; Ghasparian, Arin; Robinson, John A.; McCullough, Kenneth C.

    2012-01-01

    DC employ several endocytic routes for processing antigens, driving forward adaptive immunity. Recent advances in synthetic biology have created small (20–30 nm) virus-like particles based on lipopeptides containing a virus-derived coiled coil sequence coupled to synthetic B- and T-cell epitope mimetics. These self-assembling SVLP efficiently induce adaptive immunity without requirement for adjuvant. We hypothesized that the characteristics of DC interaction with SVLP would elaborate on the roles of cell membrane and intracellular compartments in the handling of a virus-like entity known for its efficacy as a vaccine. DC rapidly bind SVLP within min, co-localised with CTB and CD9, but not caveolin-1. In contrast, internalisation is a relatively slow process, delivering SVLP into the cell periphery where they are maintained for a number of hrs in association with microtubules. Although there is early association with clathrin, this is no longer seen after 10 min. Association with EEA-1+ early endosomes is also early, but proteolytic processing appears slow, the SVLP-vesicles remaining peripheral. Association with transferrin occurs rarely, and only in the periphery, possibly signifying translocation of some SVLP for delivery to B-lymphocytes. Most SVLP co-localise with high molecular weight dextran. Uptake of both is impaired with mature DC, but there remains a residual uptake of SVLP. These results imply that DC use multiple endocytic routes for SVLP uptake, dominated by caveolin-independent, lipid raft-mediated macropinocytosis. With most SVLP-containing vesicles being retained in the periphery, not always interacting with early endosomes, this relates to slow proteolytic degradation and antigen retention by DC. The present characterization allows for a definition of how DC handle virus-like particles showing efficacious immunogenicity, elements valuable for novel vaccine design in the future. PMID:22905240

  13. Denitrifiers in the surface zone are primarily responsible for the nitrous oxide emission of dairy manure compost

    Energy Technology Data Exchange (ETDEWEB)

    Maeda, Koki, E-mail: k_maeda@affrc.go.jp [Dairy Research Division, National Agricultural Research Center for Hokkaido Region, National Agricultural and Food Research Organization, 1 Hitsujigaoka, Sapporo 062-8555 (Japan); Department of Environmental Chemistry and Engineering, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8502 (Japan); Toyoda, Sakae [Department of Environmental Chemistry and Engineering, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8502 (Japan); Hanajima, Dai [Dairy Research Division, National Agricultural Research Center for Hokkaido Region, National Agricultural and Food Research Organization, 1 Hitsujigaoka, Sapporo 062-8555 (Japan); Yoshida, Naohiro [Department of Environmental Chemistry and Engineering, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8502 (Japan)

    2013-03-15

    Highlights: ► Nitrous oxide (N{sub 2}O) productions of each compost zones were compared. ► The pile surface emitted significant fluxes of N{sub 2}O. ► The isotopic signature of N{sub 2}O from surface and NO{sub 2}{sup −} amended core were different. ► The denitrifying gene abundance was significantly higher in pile surface than the pile core. -- Abstract: During the dairy manure composting process, significant nitrous oxide (N{sub 2}O) emissions occur just after the pile turnings. To understand the characteristics of this N{sub 2}O emission, samples were taken from the compost surface and core independently, and the N{sub 2}O production was monitored in laboratory incubation experiments. Equal amounts of surface and core samples were mixed to simulate the turning, and the {sup 15}N isotope ratios within the molecules of produced N{sub 2}O were analyzed by isotopomer analysis. The results showed that the surface samples emitted significant levels of N{sub 2}O, and these emissions were correlated with NO{sub x}{sup −}-N accumulation. Moreover, the surface samples and surface-core mixed samples incubated at 30 °C produced N{sub 2}O with a low site preference (SP) value (−0.9 to 7.0‰) that was close to bacteria denitrification (0‰), indicating that denitrifiers in the surface samples are responsible for this N{sub 2}O production. On the other hand, N{sub 2}O produced by NO{sub 2}{sup −}-amended core samples and surface samples incubated at 60 °C showed unrecognized isotopic signatures (SP = 11.4–20.3‰). From these results, it was revealed that the N{sub 2}O production occurring just after the turnings was mainly derived from bacterial denitrification (including nitrifier denitrification) of NO{sub x}{sup −}-N under mesophilic conditions, and surface denitrifying bacteria appeared to be the main contributor to this process.

  14. Comparative genome analysis of Pseudogymnoascus spp. reveals primarily clonal evolution with small genome fragments exchanged between lineages.

    Science.gov (United States)

    Leushkin, Evgeny V; Logacheva, Maria D; Penin, Aleksey A; Sutormin, Roman A; Gerasimov, Evgeny S; Kochkina, Galina A; Ivanushkina, Natalia E; Vasilenko, Oleg V; Kondrashov, Alexey S; Ozerskaya, Svetlana M

    2015-05-21

    Pseudogymnoascus spp. is a wide group of fungi lineages in the family Pseudorotiaceae including an aggressive pathogen of bats P. destructans. Although several lineages of P. spp. were shown to produce ascospores in culture, the vast majority of P. spp. demonstrates no evidence of sexual reproduction. P. spp. can tolerate a wide range of different temperatures and salinities and can survive even in permafrost layer. Adaptability of P. spp. to different environments is accompanied by extremely variable morphology and physiology. We sequenced genotypes of 14 strains of P. spp., 5 of which were extracted from permafrost, 1 from a cryopeg, a layer of unfrozen ground in permafrost, and 8 from temperate surface environments. All sequenced genotypes are haploid. Nucleotide diversity among these genomes is very high, with a typical evolutionary distance at synonymous sites dS ≈ 0.5, suggesting that the last common ancestor of these strains lived >50 Mya. The strains extracted from permafrost do not form a separate clade. Instead, each permafrost strain has close relatives from temperate environments. We observed a strictly clonal population structure with no conflicting topologies for ~99% of genome sequences. However, there is a number of short (~100-10,000 nt) genomic segments with the total length of 67.6 Kb which possess phylogenetic patterns strikingly different from the rest of the genome. The most remarkable case is a MAT-locus, which has 2 distinct alleles interspersed along the whole-genome phylogenetic tree. Predominantly clonal structure of genome sequences is consistent with the observations that sexual reproduction is rare in P. spp. Small number of regions with noncanonical phylogenies seem to arise due to some recombination events between derived lineages of P. spp., with MAT-locus being transferred on multiple occasions. All sequenced strains have heterothallic configuration of MAT-locus.

  15. OCA1 in different ethnic groups of india is primarily due to founder mutations in the tyrosinase gene.

    NARCIS (Netherlands)

    Chaki, M.; Sengupta, M.S.; Mukhopadhyay, A.; Subba Rao, I.; Majumder, P.P.; Das, M.; Samanta, S.; Ray, K.

    2006-01-01

    Oculocutaneous albinism (OCA) is a heterogeneous group of autosomal recessive disorders characterized by an abnormally low amount of melanin in the eyes, skin and hair, and associated with common developmental abnormalities of the eye. Defects in the tyrosinase gene (TYR) cause a common type of OCA,

  16. Stress-induced grey matter loss determined by MRI is primarily due to loss of dendrites and their synapses.

    Science.gov (United States)

    Kassem, Mustafa S; Lagopoulos, Jim; Stait-Gardner, Tim; Price, William S; Chohan, Tariq W; Arnold, Jonathon C; Hatton, Sean N; Bennett, Maxwell R

    2013-04-01

    Stress, unaccompanied by signs of post-traumatic stress disorder, is known to decrease grey matter volume (GMV) in the anterior cingulate cortex (ACC) and hippocampus but not the amygdala in humans. We sought to determine if this was the case in stressed mice using high-resolution magnetic resonance imaging (MRI) and to identify the cellular constituents of the grey matter that quantitatively give rise to such changes. Stressed mice showed grey matter losses of 10 and 15 % in the ACC and hippocampus, respectively but not in the amygdala or the retrosplenial granular area (RSG). Concurrently, no changes in the number or volumes of the somas of neurons, astrocytes or oligodendrocytes were detected. A loss of synaptic spine density of up to 60 % occurred on different-order dendrites in the ACC and hippocampus (CA1) but not in the amygdala or RSG. The loss of spines was accompanied by decreases in cumulative dendritic length of neurons of over 40 % in the ACC and hippocampus (CA1) giving rise to decreases in volume of dendrites of 2.6 mm(3) for the former and 0.6 mm(3) for the latter, with no change in the amygdala or RSG. These values are similar to the MRI-determined loss of GMV following stress of 3.0 and 0.8 mm(3) in ACC and hippocampus, respectively, with no changes in the amygdala or RSG. This quantitative study is the first to relate GMV changes in the cortex measured with MRI to volume changes in cellular constituents of the grey matter.

  17. Memory deficits in long-term survivors of childhood brain tumors may primarily reflect general cognitive dysfunctions

    DEFF Research Database (Denmark)

    Reimers, Tonny Solveig; Mortensen, Erik Lykke; Schmiegelow, Kjeld

    2007-01-01

    To analyze the impact of potential predictors on memory performance in survivors of childhood brain tumors and to examine whether deficits in memory after radiotherapy (RT) should be considered part of a more global mental dysfunction.......To analyze the impact of potential predictors on memory performance in survivors of childhood brain tumors and to examine whether deficits in memory after radiotherapy (RT) should be considered part of a more global mental dysfunction....

  18. PTSD, food addiction, and disordered eating in a sample of primarily older veterans: The mediating role of emotion regulation.

    Science.gov (United States)

    Mitchell, Karen S; Wolf, Erika J

    2016-09-30

    Posttraumatic stress disorder (PTSD) has been associated with eating disorders (EDs) and addictive behaviors, including the relatively new construct food addiction. However, few studies have investigated mechanisms that account for these associations, and men are underrepresented in studies of EDs and food addiction. We examined whether lifetime PTSD symptoms were associated with current food addiction and ED symptoms, and whether emotion regulation (expressive suppression and cognitive reappraisal), which has been associated with both PTSD and EDs, mediated these relations, in a sample of trauma-exposed, male (n=642) and female (n=55) veterans. Participants were recruited from the Knowledge Networks-GfK Research Panel and completed an online questionnaire. Structural equation modeling revealed that PTSD was directly associated with ED symptoms, food addiction, expressive suppression, and cognitive reappraisal in the full sample and with all constructs except cognitive reappraisal in the male subsample. Expressive suppression was significantly associated with ED symptoms and mediated the PTSD-ED relation. These results highlight the importance of investigating PTSD as a risk factor for food addiction and ED symptoms and the potential mediating role of emotion regulation in the development of PTSD and EDs in order to identify targets for treatments. Published by Elsevier Ireland Ltd.

  19. Hospitalization and mortality among primarily nonbreastfed children during a large outbreak of diarrhea and malnutrition in Botswana, 2006.

    Science.gov (United States)

    Creek, Tracy L; Kim, Andrea; Lu, Lydia; Bowen, Anna; Masunge, Japhter; Arvelo, Wences; Smit, Molly; Mach, Ondrej; Legwaila, Keitumetse; Motswere, Catherine; Zaks, Laurel; Finkbeiner, Thomas; Povinelli, Laura; Maruping, Maruping; Ngwaru, Gibson; Tebele, Goitebetswe; Bopp, Cheryl; Puhr, Nancy; Johnston, Stephanie P; Dasilva, Alexandre J; Bern, Caryn; Beard, R S; Davis, Margarett K

    2010-01-01

    In 2006, a pediatric diarrhea outbreak occurred in Botswana, coinciding with heavy rains. Surveillance recorded a 3 times increase in cases and a 25 fold increase in deaths between January and March. Botswana has high HIV prevalence among pregnant women (33.4% in 2005), and an estimated 35% of all infants under the age of 6 months are not breastfed. We followed all children <5 years old with diarrhea in the country's second largest referral hospital at the peak of the outbreak by chart review, interviewed mothers, and conducted laboratory testing for HIV and enteric pathogens. Of 153 hospitalized children with diarrhea, 97% were <2 years old; 88% of these were not breastfeeding. HIV was diagnosed in 18% of children and 64% of mothers. Cryptosporidium and enteropathogenic Escherichia coli were common; many children had multiple pathogens. Severe acute malnutrition (kwashiorkor or marasmus) developed in 38 (25%) patients, and 33 (22%) died. Kwashiorkor increased risk for death (relative risk 2.0; P = 0.05); only one breastfeeding child died. Many children who died had been undersupplied with formula. Most of the severe morbidity and mortality in this outbreak occurred in children who were HIV negative and not breastfed. Feeding and nutritional factors were the most important determinants of severe illness and death. Breastfeeding is critical to infant survival in the developing world, and support for breastfeeding among HIV-negative women, and HIV-positive women who cannot formula feed safely, may prevent further high-mortality outbreaks.

  20. CPAP Adherence is Associated With Attentional Improvements in a Group of Primarily Male Patients With Moderate to Severe OSA.

    Science.gov (United States)

    Deering, Sean; Liu, Lin; Zamora, Tania; Hamilton, Joanne; Stepnowsky, Carl

    2017-12-15

    Obstructive sleep apnea (OSA) is a widespread condition that adversely affects physical health and cognitive functioning. The prevailing treatment for OSA is continuous positive airway pressure (CPAP), but therapeutic benefits are dependent on consistent use. Our goal was to investigate the relationship between CPAP adherence and measures of sustained attention in patients with OSA. Our hypothesis was that the Psychomotor Vigilance Task (PVT) would be sensitive to attention-related improvements resulting from CPAP use. This study was a secondary analysis of a larger clinical trial. Treatment adherence was determined from CPAP use data. Validated sleep-related questionnaires and a sustained-attention and alertness test (PVT) were administered to participants at baseline and at the 6-month time point. Over a 6-month time period, the average CPAP adherence was 3.32 h/night (standard deviation [SD] = 2.53), average improvement in PVT minor lapses was -4.77 (SD = 13.2), and average improvement in PVT reaction time was -73.1 milliseconds (standard deviation = 211). Multiple linear regression analysis showed that higher CPAP adherence was significantly associated with a greater reduction in minor lapses in attention after 6 months of continuous treatment with CPAP therapy (β = -0.72, standard error = 0.34, P = .037). The results of this study showed that higher levels of CPAP adherence were associated with significant improvements in vigilance. Because the PVT is a performance-based measure that is not influenced by prior learning and is not subjective, it may be an important supplement to patient self-reported assessments. Name: Effect of Self-Management on Improving Sleep Apnea Outcomes, URL: https://clinicaltrials.gov/ct2/show/NCT00310310, Identifier: NCT00310310. © 2017 American Academy of Sleep Medicine

  1. The acute effect of metformin on glucose production in the conscious dog is primarily attributable to inhibition of glycogenolysis.

    Science.gov (United States)

    Chu, C A; Wiernsperger, N; Muscato, N; Knauf, M; Neal, D W; Cherrington, A D

    2000-12-01

    Although metformin has been used worldwide to treat type 2 diabetes for several decades, its mechanism of action on glucose homeostasis remains controversial. To further assess the effect of metformin on glucose metabolism, 10 42-hour-fasted conscious dogs were studied in the absence ([Con] n = 5) and presence ([Met] n = 5) of a portal infusion of metformin (0.15 mg x kg(-1) x min(-1)) over 300 minutes. Hepatic glucose production was measured by both arteriovenous-difference and tracer methods. All dogs were maintained on a pancreatic clamp and in a euglycemic state to ensure that any changes in glucose metabolism would result directly from the effects of metformin. The arterial metformin level was 21 +/- 3 microg/mL during the test period. Net hepatic glucose output (NHGO) decreased in Met dogs from 1.9 +/- 0.2 to 0.7 +/- 0.1 mg x kg(-1) x min(-1) (P metformin on glucose metabolism was an inhibition of hepatic glucose production and not a stimulation of glucose utilization; and (2) the inhibition of glucose production was attributable to a decrease in hepatic glycogenolysis and not to an alteration in gluconeogenic flux.

  2. Receptor-binding properties of modern human influenza viruses primarily isolated in Vero and MDCK cells and chicken embryonated eggs

    International Nuclear Information System (INIS)

    Mochalova, Larisa; Gambaryan, Alexandra; Romanova, Julia; Tuzikov, Alexander; Chinarev, Alexander; Katinger, Dietmar; Katinger, Herman; Egorov, Andrej; Bovin, Nicolai

    2003-01-01

    To study the receptor specificity of modern human influenza H1N1 and H3N2 viruses, the analogs of natural receptors, namely sialyloligosaccharides conjugated with high molecular weight (about 1500 kDa) polyacrylamide as biotinylated and label-free probes, have been used. Viruses isolated from clinical specimens were grown in African green monkey kidney (Vero) or Madin-Darby canine kidney (MDCK) cells and chicken embryonated eggs. All Vero-derived viruses had hemagglutinin (HA) sequences indistinguishable from original viruses present in clinical samples, but HAs of three of seven tested MDCK-derived isolates had one or two amino acid substitutions. Despite these host-dependent mutations and differences in the structure of HA molecules of individual strains, all studied Vero- and MDCK-isolated viruses bound to Neu5Ac α2-6Galβ1-4GlcNAc (6'SLN) essentially stronger than to Neu5Acα2-6Galβ1-4Glc (6'SL). Such receptor-binding specificity has been typical for earlier isolated H1N1 human influenza viruses, but there is a new property of H3N2 viruses that has been circulating in the human population during recent years. Propagation of human viruses in chicken embryonated eggs resulted in a selection of variants with amino acid substitutions near the HA receptor-binding site, namely Gln226Arg or Asp225Gly for H1N1 viruses and Leu194Ile and Arg220Ser for H3N2 viruses. These HA mutations disturb the observed strict 6'SLN specificity of recent human influenza viruses

  3. Positioning Your Library for Solar (and Financial) Gain. Improving Energy Efficiency, Lighting, and Ventilation with Primarily Passive Techniques

    Science.gov (United States)

    Shane, Jackie

    2012-01-01

    This article stresses the importance of building design above technology as a relatively inexpensive way to reduce energy costs for a library. Emphasis is placed on passive solar design for heat and daylighting, but also examines passive ventilation and cooling, green roofs, and building materials. Passive design is weighed against technologies…

  4. The leukemia-specific fusion gene ETV6/RUNX1 perturbs distinct key biological functions primarily by gene repression.

    Directory of Open Access Journals (Sweden)

    Gerhard Fuka

    Full Text Available BACKGROUND: ETV6/RUNX1 (E/R (also known as TEL/AML1 is the most frequent gene fusion in childhood acute lymphoblastic leukemia (ALL and also most likely the crucial factor for disease initiation; its role in leukemia propagation and maintenance, however, remains largely elusive. To address this issue we performed a shRNA-mediated knock-down (KD of the E/R fusion gene and investigated the ensuing consequences on genome-wide gene expression patterns and deducible regulatory functions in two E/R-positive leukemic cell lines. FINDINGS: Microarray analyses identified 777 genes whose expression was substantially altered. Although approximately equal proportions were either up- (KD-UP or down-regulated (KD-DOWN, the effects on biological processes and pathways differed considerably. The E/R KD-UP set was significantly enriched for genes included in the "cell activation", "immune response", "apoptosis", "signal transduction" and "development and differentiation" categories, whereas in the E/R KD-DOWN set only the "PI3K/AKT/mTOR signaling" and "hematopoietic stem cells" categories became evident. Comparable expression signatures obtained from primary E/R-positive ALL samples underline the relevance of these pathways and molecular functions. We also validated six differentially expressed genes representing the categories "stem cell properties", "B-cell differentiation", "immune response", "cell adhesion" and "DNA damage" with RT-qPCR. CONCLUSION: Our analyses provide the first preliminary evidence that the continuous expression of the E/R fusion gene interferes with key regulatory functions that shape the biology of this leukemia subtype. E/R may thus indeed constitute the essential driving force for the propagation and maintenance of the leukemic process irrespective of potential consequences of associated secondary changes. Finally, these findings may also provide a valuable source of potentially attractive therapeutic targets.

  5. The value of 3 T MR diffusion tensor fiber tractography study of association fasciculus of normative human in vivo primarily

    International Nuclear Information System (INIS)

    Sun Xuejin; Dai Jianping; Gao Peiyi; Li Shaowu; Ai Lin; Chen Hongyan; Tian Shengyong; Pang Ruilin

    2006-01-01

    Objective: To exhibit the fibers of association fascicules, aims at demonstrating the association fibers of brain with diffusion tensor fiber tracking technique. Methods: Conventionality MRI, diffusion tensor imaging (DTI) and diffusion tensor fiber tractography (DT-FT) were performed in twenty healthy subjects, including eighteen right-handed (sixteen men and four women) and two left-handed (one male and one female) by 3 T Siemens Trio 2003 T MRI. To select arcuate fascicules, inferior longitudinal fascicules, frontalwoceipital fascicules, corpus callosum, posterior limb of internal capsule and external capsule as seeds used to track fibers. Results: Diffusion tensor fiber tracking exhibited bundles of external capsule left mean fibers were 308 bundles, right fibers were 307 bundles (t=0.138, P>0.05), frontal-occipital tracks left mean fibers were 115 bundles, right fibers were 110 bundles(t=1.174, P>0.05), and their fractional anisotropy (FA) valueexternal capsule mean FA left was 0.361, the right was 0.362 (t=-0.184, P>0.05). Frontal-occipital tracks mean fractional anisotropy left was 0.352, the right was 0.351 (t=-0.816, P>0.05). The difference between both sides were statistically insignificant (P>0.05). The posterior limb of internal capsule left mean fibers were 249 bundles, right fibers were 257 bundles (t=-0.818, P>0.05), arcuate fascietfiesleft mean fibers were 198 bundles, right fibers were 204 bundles (t=-0.465, P>0.05 ) fibers difference between both sides were statistically insignificant (P>0.05), but the individual difference was significant, and their fractional anisotropy difference between both sides (posterior limb of internal capsule mean FA left was 0.450, the right was 0.444 (t=2.771, P 0.05). Mean FA left was 0.369, the right was 0.370(t=-0.178, P>0.05) ,difference between both sides was statistically insignificant (P>0.05). But the individual difference was significant. Some of them were the left larger than the right side. The frontal parts kept in touch with the Broca area of the left posterior of inferior frontal gyre. Conclusions: There is individual difference both sides of association fascicules. There may be a new fiber bundle in the hemisphere, and associate with frontal lobe, temporal lobe, parietal lobe and occipital lobe. (authors)

  6. Little-known truths, quirky anecdotes, seething scandals, and even some science in the history of (primarily achievement) motivation.

    Science.gov (United States)

    Weiner, Bernard

    2013-08-01

    This article presents a history of the study of motivation from approximately 1900-1975, focusing on achievement strivings and containing little-known and often surprising facts about the main contributors to this field. Four theorists are highlighted: David McClelland, Kurt Lewin, John Atkinson, and Fritz Heider, each associated with a different theoretical approach (respectively and in order of historical emergence: trait, Gestalt, expectancy/value, and attribution theory). A fifth conception, drive theory, is also represented. In addition, a number of individuals who influenced these theorists and others who followed them are discussed. The article emphasizes the interrelations between the theorists and the interaction between personal and scientific life.

  7. The Duration of Motor Responses Evoked with Intracortical Microstimulation in Rats Is Primarily Modulated by Stimulus Amplitude and Train Duration.

    Directory of Open Access Journals (Sweden)

    Meghan Watson

    Full Text Available Microstimulation of brain tissue plays a key role in a variety of sensory prosthetics, clinical therapies and research applications, however the effects of stimulation parameters on the responses they evoke remain widely unknown. In particular, the effects of parameters when delivered in the form of a stimulus train as opposed to a single pulse are not well understood despite the prevalence of stimulus train use. We aimed to investigate the contribution of each parameter of a stimulus train to the duration of the motor responses they evoke in forelimb muscles. We used constant-current, biphasic, square wave pulse trains in acute terminal experiments under ketamine anaesthesia. Stimulation parameters were systematically tested in a pair-wise fashion in the caudal forelimb region of the motor cortex in 7 Sprague-Dawley rats while motor evoked potential (MEP recordings from the forelimb were used to quantify the influence of each parameter in the train. Stimulus amplitude and train duration were shown to be the dominant parameters responsible for increasing the total duration of the MEP, while interphase interval had no effect. Increasing stimulus frequency from 100-200 Hz or pulse duration from 0.18-0.34 ms were also effective methods of extending response durations. Response duration was strongly correlated with peak time and amplitude. Our findings suggest that motor cortex intracortical microstimulations are often conducted at a higher frequency rate and longer train duration than necessary to evoke maximal response duration. We demonstrated that the temporal properties of the evoked response can be both predicted by certain response metrics and modulated via alterations to the stimulation signal parameters.

  8. Energetic Systems

    Data.gov (United States)

    Federal Laboratory Consortium — The Energetic Systems Division provides full-spectrum energetic engineering services (project management, design, analysis, production support, in-service support,...

  9. Intelligent systems

    CERN Document Server

    Irwin, J David

    2011-01-01

    Technology has now progressed to the point that intelligent systems are replacing humans in the decision making processes as well as aiding in the solution of very complex problems. In many cases intelligent systems are already outperforming human activities. Artificial neural networks are not only capable of learning how to classify patterns, such images or sequence of events, but they can also effectively model complex nonlinear systems. Their ability to classify sequences of events is probably more popular in industrial applications where there is an inherent need to model nonlinear system

  10. Systemic darwinism.

    Science.gov (United States)

    Winther, Rasmus Grønfeldt

    2008-08-19

    Darwin's 19th century evolutionary theory of descent with modification through natural selection opened up a multidimensional and integrative conceptual space for biology. We explore three dimensions of this space: explanatory pattern, levels of selection, and degree of difference among units of the same type. Each dimension is defined by a respective pair of poles: law and narrative explanation, organismic and hierarchical selection, and variational and essentialist thinking. As a consequence of conceptual debates in the 20th century biological sciences, the poles of each pair came to be seen as mutually exclusive opposites. A significant amount of 21st century research focuses on systems (e.g., genomic, cellular, organismic, and ecological/global). Systemic Darwinism is emerging in this context. It follows a "compositional paradigm" according to which complex systems and their hierarchical networks of parts are the focus of biological investigation. Through the investigation of systems, Systemic Darwinism promises to reintegrate each dimension of Darwin's original logical space. Moreover, this ideally and potentially unified theory of biological ontology coordinates and integrates a plurality of mathematical biological theories (e.g., self-organization/structure, cladistics/history, and evolutionary genetics/function). Integrative Systemic Darwinism requires communal articulation from a plurality of perspectives. Although it is more general than these, it draws on previous advances in Systems Theory, Systems Biology, and Hierarchy Theory. Systemic Darwinism would greatly further bioengineering research and would provide a significantly deeper and more critical understanding of biological reality.

  11. Can the same edge-detection algorithm be applied to on-line and off-line analysis systems? Validation of a new cinefilm-based geometric coronary measurement software

    NARCIS (Netherlands)

    J. Haase (Jürgen); C. di Mario (Carlo); P.W.J.C. Serruys (Patrick); M.M.J.M. van der Linden (Mark); D.P. Foley (David); W.J. van der Giessen (Wim)

    1993-01-01

    textabstractIn the Cardiovascular Measurement System (CMS) the edge-detection algorithm, which was primarily designed for the Philips digital cardiac imaging system (DCI), is applied to cinefilms. Comparative validation of CMS and DCI was performed in vitro and in vivo with intracoronary insertion

  12. Structure of a traditional baseline data system

    Energy Technology Data Exchange (ETDEWEB)

    1976-12-01

    Research was conducted to determine whether appropriate data exist for the development of a comprehensive statistical baseline data system on the human environment in the Athabasca oil sands region of Alberta. The existing data sources pertinent to the target area were first reviewed and discussed. Criteria were selected to assist the evaluation of data, including type of data collected, source, degree of detail, geographic identification, accessibility, and time frame. These criteria allowed assessing whether the data would be amenable to geographically-coded, continuous monitoring systems. It was found that the Statistics Canada Census provided the most detail, the most complete coverage of the target area, the smallest statistical areas, the greatest consistency in data and data collection, and the most regular collection. The local agency collection efforts were generally oriented toward specific goals and the data intended primarily for intra-agency use. The smallest statistical units in these efforts may be too large to be of value to a common small-area system, and data collection agencies did not generally use coterminous boundaries. Recommendations were made to give primary consideration to Statistics Canada data in the initial development of the baseline data system. Further development of such a system depends on the adoption by local agencies of a common small-area system for data collection. 38 refs., 6 figs.

  13. Mission Data System Java Edition Version 7

    Science.gov (United States)

    Reinholtz, William K.; Wagner, David A.

    2013-01-01

    The Mission Data System framework defines closed-loop control system abstractions from State Analysis including interfaces for state variables, goals, estimators, and controllers that can be adapted to implement a goal-oriented control system. The framework further provides an execution environment that includes a goal scheduler, execution engine, and fault monitor that support the expression of goal network activity plans. Using these frameworks, adapters can build a goal-oriented control system where activity coordination is verified before execution begins (plan time), and continually during execution. Plan failures including violations of safety constraints expressed in the plan can be handled through automatic re-planning. This version optimizes a number of key interfaces and features to minimize dependencies, performance overhead, and improve reliability. Fault diagnosis and real-time projection capabilities are incorporated. This version enhances earlier versions primarily through optimizations and quality improvements that raise the technology readiness level. Goals explicitly constrain system states over explicit time intervals to eliminate ambiguity about intent, as compared to command-oriented control that only implies persistent intent until another command is sent. A goal network scheduling and verification process ensures that all goals in the plan are achievable before starting execution. Goal failures at runtime can be detected (including predicted failures) and handled by adapted response logic. Responses can include plan repairs (try an alternate tactic to achieve the same goal), goal shedding, ignoring the fault, cancelling the plan, or safing the system.

  14. Theoretical modelling of quantum circuit systems

    International Nuclear Information System (INIS)

    Stiffell, Peter Barry

    2002-01-01

    The work in this thesis concentrates on the interactions between circuit systems operating in the quantum regime. The main thrust of this work involves the use of a new model for investigating the way in which different components in such systems behave when coupled together. This is achieved by utilising the matrix representation of quantum mechanics, in conjunction with a number of other theoretical techniques (such as Wigner functions and entanglement entropies). With these tools in place it then becomes possible to investigate and review different quantum circuit systems. These investigations cover systems ranging from simple electromagnetic (cm) field oscillators in isolation to coupled SQUID rings in more sophisticated multi-component arrangements. Primarily, we look at the way SQUID rings couple to em fields, and how the ring-field interaction can be mediated by the choice of external flux, Φ x , applied to the SQUID ring. A lot of interest is focused on the transfer of energy between the system modes. However, we also investigate the statistical properties of the system, including squeezing, entropy and entanglement. Among the phenomena uncovered in this research we note the ability to control coupling in SQUID rings via the external flux, the capacity for entanglement between quantum circuit modes, frequency conversions of photons, flux squeezing and the existence of Schroedinger Cat states. (author)

  15. VXIbus data collection system -- A design study

    International Nuclear Information System (INIS)

    Hacker, U.; Richter, B.; Weinert, A.; Arlt, R.; Lewis, W.; Swinhoe, M.

    1995-01-01

    The German support program has sponsored the work to investigate the VXIbus as integration platform for safeguards instrumentation. This paper will cover the analysis of the user requirements for a VXIbus based monitoring system for integrated safeguards -- primarily for reliable unattended in-field collection of large amounts of data. The goal is to develop a suitable system architecture. The design of the system makes use of the VXIbus standard as the selected hardware platform Based upon the requirement analysis and the overriding need for high reliability and robustness, a systematic investigation of different operating system options, as well as development and integration tools will be considered. For the software implementation cycle high and low level programming tools are required. The identification of the constraints for the programming platform and the tool selection will be presented. Both the strategic approach, the rules for analysis and design work as well as the executive components for the support of the implementation and production cycle are given. Here all the conditions for reliable, unattended and integrated safeguards monitoring systems will be addressed. The definition of the basic and advanced design principles are covered. The paper discusses the results of a study on a system produced to demonstrate a high data rate timer/counter application

  16. Supporting the Support System: How Assessment and Communication Can Help Patients and Their Support Systems.

    Science.gov (United States)

    Harkey, Jane; Young, Jared; Carter, Jolynne Jo; Demoratz, Michael

    The benefits of having a support system, such as social relationships with close friends and family, have been well documented for patients with serious health issues. As scientific evidence has shown, individuals who have the lowest level of involvement in social relationships face a greater mortality risk. Support systems, however, are not infallible. Relationship stress can have a negative impact on people-patient and caregiver alike-behaviorally, psychosocially, and physiologically. The purpose of this article is to encourage case managers who take a patient-centered approach to also consider the existence and extent of the support system, as well as any stresses or tensions that are observable within the support system. Although the case manager is ethically obliged to advocate for the individual receiving case management services, that advocacy can be extended to the support system for the good of all. This discussion applies to numerous case management practices and work settings including (but not limited to) hospital-based case management, home health, geriatrics, catastrophic case management, mental health, palliative care, and end of life/hospice. As part of the assessment phase of the case management process, case managers determine the extent of the patient's support system or social support network such as family and close friends. Although their advocacy is primarily for the patient receiving case management services, case managers also become aware of the needs of the support system members as they face their loved one's serious illness, severe injury, geriatric care demands, or end of life. Case managers can use their communication skills, especially motivational interviewing, with patients and their support systems to identify stresses and issues that can impact the pursuit of health goals. In addition, case managers ensure that individuals and their support systems are kept informed such as about the health condition, stage of disease, plan of

  17. Sustainability Assessment of the Agricultural and Energy Systems of Senegal

    Directory of Open Access Journals (Sweden)

    Kyrke Gaudreau

    2015-04-01

    Full Text Available To improve decision-making, sustainability-based approaches to assessment of options and undertakings demand that we move beyond narrowly defined considerations to address the full suite of requirements for progress towards sustainability. This paper reports on a sustainability assessment exercise that originally focused on burning agricultural residues, primarily peanut shells, for cooking applications in Senegal. The scope of assessment had to be expanded to address the agricultural and energy systems of Senegal, when closer examination revealed a complex set of energy and agricultural system interactions that could undermine the anticipated positive effects of initiatives centred primarily on peanut residue cookstoves. The case highlights the need to be open to expanding the scope of assessment to address underlying and/or unexpected issues that cannot be addressed appropriately at the project scale. In particular, the case illustrates how the assessment of an energy system may serve as an entry point into a deeper exploration of the context in which the energy system is embedded. The analysis also illustrates a situation in which different paths that may be followed, each with its own degree of uncertainty, path dependence, feasibility, fairness, cultural sensitivity, trade-off acceptability and possibilities for public judgement of overall desirability.

  18. Implementation and Rejection of Industrial Steam System Energy Efficiency Measures

    Energy Technology Data Exchange (ETDEWEB)

    Therkelesen, Peter [Environmental Energy Technologies Division Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); McKane, Aimee [Environmental Energy Technologies Division Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

    2013-05-01

    Steam systems consume approximately one third of energy applied at U.S. industrial facilities. To reduce energy consumption, steam system energy assessments have been conducted on a wide range of industry types over the course of five years through the Energy Savings Assessment (ESA) program administered by the U.S. Department of Energy (U.S. DOE). ESA energy assessments result in energy efficiency measure recommendations that are given potential energy and energy cost savings and potential implementation cost values. Saving and cost metrics that measure the impact recommended measures will have at facilities, described as percentages of facility baseline energy and energy cost, are developed from ESA data and used in analyses. Developed savings and cost metrics are examined along with implementation and rejection rates of recommended steam system energy efficiency measures. Based on analyses, implementation of steam system energy efficiency measures is driven primarily by cost metrics: payback period and measure implementation cost as a percentage of facility baseline energy cost (implementation cost percentage). Stated reasons for rejecting recommended measures are primarily based upon economic concerns. Additionally, implementation rates of measures are not only functions of savings and cost metrics, but time as well.

  19. Caste System

    OpenAIRE

    Hoff, Karla

    2016-01-01

    In standard economics, individuals are rational actors and economic forces undermine institutions that impose large inefficiencies. The persistence of the caste system is evidence of the need for psychologically more realistic models of decision-making in economics. The caste system divides South Asian society into hereditary groups whose lowest ranks are represented as innately polluted. ...

  20. Recommender systems

    OpenAIRE

    Lu L.; Medo M.; Yeung C.H.; Zhang Y.-C.; Zhang Z.-K.; Zhou T.

    2012-01-01

    The ongoing rapid expansion of the Internet greatly increases the necessity of effective recommender systems for filtering the abundant information. Extensive research for recommender systems is conducted by a broad range of communities including social and computer scientists, physicists, and interdisciplinary researchers. Despite substantial theoretical and practical achievements, unification and comparison of different approaches are lacking, which impedes further advances. In this article...

  1. GEOMASS system

    International Nuclear Information System (INIS)

    Ohyama, Takuya; Saegusa, Hiromitsu

    2009-03-01

    As a part of the research and development regarding characterisation of deep geological environment, the GEOMASS (GEOLOGICAL MODELLING ANALYSIS AND SIMULATION SOFTWARE) system has been developed by the Japan Atomic Energy Agency in order to carry out geological and hydrogeological modelling and groundwater flow simulation and so on. The GEOMASS system integrates a commercial geological interpretation system (EarthVision), which is used for geological modelling and visualisation, with a proprietary code for groundwater flow (FracAffinity). This integrated system allows users to make rapid improvement of models as data increases. Also, it is possible to perform more realistic groundwater flow simulation due to the capability of modelling the rock mass as a continuum with discrete hydro-structural features in the rock mass. This paper consists of 'Overview of GEOMASS system', FracAffinity Theoretical Background' and 'FracAffinity User Guide' and is edited as a GEOMASS system manual. 'Overview of GEOMASS system' describes the outline of this system. 'FracAffinity Theoretical Background' describes the information of technical background of FracAffinity software. FracAffinity User Guide' describes the structure of the FracAffinity input files, the usage of FracAffinity Interface and flow-solver. Updating of the FracAffinity has been continued as needed and FracAffinity version3.3 is the latest version at present (July 2008). (author)

  2. Systems integration (automation system). System integration (automation system)

    Energy Technology Data Exchange (ETDEWEB)

    Fujii, K; Komori, T; Fukuma, Y; Oikawa, M [Nippon Steal Corp., Tokyo (Japan)

    1991-09-26

    This paper introduces business activities on an automation systems integration (SI) started by a company in July,1988, and describes the SI concepts. The business activities include, with the CIM (unified production carried out on computers) and AMENITY (living environment) as the mainstays, a single responsibility construction ranging from consultation on structuring optimal systems for processing and assembling industries and intelligent buildings to system design, installation and after-sales services. With an SI standing on users {prime} position taken most importantly, the business starts from a planning and consultation under close coordination. On the conceptual basis of structuring optimal systems using the ompany {prime}s affluent know-hows and tools and adapting and applying with multi-vendors, open networks, centralized and distributed systems, the business is promoted with the accumulated technologies capable of realizing artificial intelligence and neural networks in its background, and supported with highly valuable business results in the past. 10 figs., 1 tab.

  3. Creative Systems

    DEFF Research Database (Denmark)

    Manelius, Anne-Mette; Beim, Anne

    2007-01-01

    Opsamling af diskussioner på konferencen og udstillingen Creative Systems i september/oktober 2007. Konferencen og Udstillingen Creative Systems sætter fokus på systemer som en positiv drivkraft i den kreative skabelsesproces. CINARK inviterede fire internationale kapaciteter, som indenfor hver...... deres felt har beskæftiget sig med udviklingen af systemer. Kieran Timberlake, markant amerikansk tegnestue; Mark West, Professor på University of Manitoba, Canada, og pioner indenfor anvendelse af tekstilforskalling til betonstøbninger; Matilda McQuaid, Arkitekturhistoriker og kurator på udstillingen...... om Extreme Textiles på amerikanske Cooper Hewit Design Museum, samt Professor Ludger Hovestadt, ved ETH, Zürich der fokuserer på udvikling og anvendelse af logaritmiske systemtilgange. Udstillingen diskuterede ud fra deres meget forskellige arbejder, det kreative potentiale i anvendelsen af systemer...

  4. Reactive Systems

    DEFF Research Database (Denmark)

    Aceto, Luca; Ingolfsdottir, Anna; Larsen, Kim Guldstrand

    A reactive system comprises networks of computing components, achieving their goals through interaction among themselves and their environment. Thus even relatively small systems may exhibit unexpectedly complex behaviours. As moreover reactive systems are often used in safety critical systems......, the need for mathematically based formal methodology is increasingly important. There are many books that look at particular methodologies for such systems. This book offers a more balanced introduction for graduate students and describes the various approaches, their strengths and weaknesses, and when...... they are best used. Milner's CCS and its operational semantics are introduced, together with the notions of behavioural equivalences based on bisimulation techniques and with recursive extensions of Hennessy-Milner logic. In the second part of the book, the presented theories are extended to take timing issues...

  5. Solar energy system performance evaluation: Page Jackson Elementary School, Charles Town, West Virginia, October 1979-April 1980

    Energy Technology Data Exchange (ETDEWEB)

    Howard, R.G.

    1980-01-01

    This school in Charles Town, West Virginia is equipped with 11,215 ft/sup 2/ of PPG flat-plate collectors of which 69% operate. Two insulated tanks of 10,000 gal capacity provide heat storage. A natural gas fired boiler and a chiller augment the solar heating and cooling system. Collector failure was primarily responsible for the system supplying 23% rather than the projected 85% of the heating requirement. (MHR)

  6. Usage of an interactive image analysis system for studying various parameters of etched tracks in CR-39 and Makrofol E

    International Nuclear Information System (INIS)

    Abu-Jarad, F.; Islam, M.A.; Que, A.

    1991-01-01

    An Automated Interactive Built Analysis System (IBAS) is being used to analyze the alpha and fission fragment tracks in CR-39 and Makrofol E detectors. It primarily consists of a control computer (IBAS1) and an image processor (IBAS2). The system is used for counting the nuclear tracks, measuring their areas, diameters, statistics and displaying the frequency distribution of their sizes. All information can be printed out or stored on floppy disks. (author)

  7. Upgraded RECOVER system - CASDAC system

    International Nuclear Information System (INIS)

    Yamamoto, Yoichi; Koyama, Kinji

    1992-03-01

    The CASDAC (Containment And Surveillance Data Authenticated Communication) system has been developed by JAERI for nuclear safeguards and physical protection of nuclear material. This system was designed and constructed as an upgraded RECOVER system, design concept of which was based on the original RECOVER system and also the TRANSEAVER system. Both of them were developed several years ago as a remote monitoring system for continual verification of security and safeguards status of nuclear material. The system consists of two subsystems, one of them is a Grand Command Center (GCC) subsystem and the other is a facility subsystem. Communication between the two subsystems is controlled through the international telephone line network. Therefore all communication data are encrypted to prevent access by an unauthorized person who may intend to make a falsification, or tapping. The facility subsystem has an appropriate measure that ensure data security and reliable operation under unattended mode of operator. The software of this system is designed so as to be easily used in other different types of computers. This report describes the outline of the CASDAC system and the results of its performance test. This work has been carried out in the framework of Japan Support Programme for Agency Safeguards (JASPAS) as a project, JA-1. (author)

  8. C.E.B.A.S., a closed equilibrated biological aquatic system as a possible precursor for a long-term life support system?

    Science.gov (United States)

    Blüm, V.

    C.E.B.A.S.-AQUARACK is a long-term multi-generation experimental device for aquatic organisms which is disposed for utlizitation in a space station. It results from the basic idea of a space aquarium for maintaining aquatic animals for longer periods integrated in a AQUARACK which consists of a modular animal holding tank, a semi-biological/physical water recycling system and an electronical control unit. The basic idea to replace a part of the water recycling system by a continuous culture of unicellular algae primarily leads to a second system for experiments with algae, a botanical AQUARACK consisting of an algal reactor, a water recycling and the electronical control unit. The combination of the zoological part, and the botanical part with a common control system in the AQUARACK, however, results in a ``Closed Equilibrated Biological Aquatic System'' (C.E.B.A.S.) representing an closed artificial ecosystem. Although this is disposed primarily as an experimental device for basic zoological, botanical and interdisciplinary research it opens the theoretical possibility to adapt it for combined production of animal and plant biomass on ground or in space. The paper explains the basic conception of the hardware construction of the zoological part of the system, the corresponding scientific frame program including the choice of the experimental animals and gives some selected examples of the hardware-related resrearch. It furtheron discusses the practical and economical relevance of the system in the development of a controlled aquatical life support system in general.

  9. International classifications of accounting systems as a result of influence of various environmental factors

    Directory of Open Access Journals (Sweden)

    Ivo Mijoč

    2012-12-01

    Full Text Available Activities of various environmental factors resulted in the emergence of accounting clusters that in- clude equal or similar countries, observed through evaluation (measurement criteria and publishing, which has led to group formation, i.e. clusterisation of accounting systems within similar or equal groups, subgroups and clusters. The key principle of group formation of accounting systems within certain clusters implies similar accounting practices, primarily the practice of measuring (evaluating positions and publishing information in financial reports. The measurement level and the quantity of published information is related to the environmental factors, primarily to cultural heritage, which, according to claims of numerous authors, is of crucial importance. If accounting practices of the com- pared countries are observed according to this factor, then it is possible to form at least two or more clusters, which is significant in the world of financial reporting as there are some controversies in the relation between IASB and FASB even today.

  10. Stochastic approach to error estimation for image-guided robotic systems.

    Science.gov (United States)

    Haidegger, Tamas; Gyõri, Sándor; Benyo, Balazs; Benyó, Zoltáán

    2010-01-01

    Image-guided surgical systems and surgical robots are primarily developed to provide patient safety through increased precision and minimal invasiveness. Even more, robotic devices should allow for refined treatments that are not possible by other means. It is crucial to determine the accuracy of a system, to define the expected overall task execution error. A major step toward this aim is to quantitatively analyze the effect of registration and tracking-series of multiplication of erroneous homogeneous transformations. First, the currently used models and algorithms are introduced along with their limitations, and a new, probability distribution based method is described. The new approach has several advantages, as it was demonstrated in our simulations. Primarily, it determines the full 6 degree of freedom accuracy of the point of interest, allowing for the more accurate use of advanced application-oriented concepts, such as Virtual Fixtures. On the other hand, it becomes feasible to consider different surgical scenarios with varying weighting factors.

  11. A Westinghouse designed distributed mircroprocessor based protection and control system

    International Nuclear Information System (INIS)

    Bruno, J.; Reid, J.B.

    1980-01-01

    For approximately five years, Westinghouse has been involved in the design and licensing of a distributed microprocessor based system for the protection and control of a pressurized water reactor nuclear steam supply system. A 'top-down' design methodology was used, in which the system global performance objectives were specified, followed by increasingly more detailed design specifications which ultimately decomposed the system into its basic hardware and software elements. The design process and design decisions were influenced by the recognition that the final product would have to be verified to ensure its capability to perform the safety-related functions of a class 1E protection system. The verification process mirrored the design process except that it was 'bottom-up' and thus started with the basic elements and worked upwards through the system in increasingly complex blocks. A number of areas which are of interest in a distributed system are disucssed, with emphasis on two systems. The first, the Integrated Protection System is primarily responsible for processing signals from field mounted sensors to provide for reactor trips and the initiation of the Engineered Safety Features. The Integrated Control System, which is organized in a parallel manner, processes other sensor signals and generates the necessary analog and on-off signals to maintain the plant parameters within specified limits. Points covered include system structure, systems partitioning strategies, communications techniques, software design concepts, reliability and maintainability, commercial component availability, interference susceptibility, licensing issues, and applicability. (LL)

  12. Systems Integration: RNAV and the Upgraded Third Generation System.

    Science.gov (United States)

    1976-12-01

    III~~f I I iI~ ~~~~~~~~~~~~~~ -~~;tit I l i j I l i l ~~~~~~~~~~~~~~~~ ~~~~ I ~~~~~~~ _ PRE FACE The Systems Researc h and Deve lopment Service of the... researc Ii a rid o the rw i so ) I)u1’~I is hed by t he Off i n n ’ 01’ th e Ad ii i iii I s I i a to r [4 1] on On.’ lobe r 1 ‘1 .1 )/S . The resul t i n...body aircra ft will be manufactured primarily for the domestic market , thus the total non- domestic 3ESB count was presumed to be constan t . • The

  13. Watchdog System

    DEFF Research Database (Denmark)

    Madsen, Tanja Kidholm Osmann; Bahnsen, Chris Holmberg; Jensen, Morten Bornø

    This deliverable is part of WP4. Overall WP4 is motivated by the need for automatic systems that can ease the task of annotating massive amounts of traffic data. Concretely this deliverable is related to WP4.2 - the watchdog system. The idea with the watchdog is to develop a system that can remov...... huge chunks of video data where no events/interactions of interest are occurring and hence let a user focus on manually annotation of only the interesting stuff....

  14. Dynamical systems

    CERN Document Server

    Sternberg, Shlomo

    2010-01-01

    Celebrated mathematician Shlomo Sternberg, a pioneer in the field of dynamical systems, created this modern one-semester introduction to the subject for his classes at Harvard University. Its wide-ranging treatment covers one-dimensional dynamics, differential equations, random walks, iterated function systems, symbolic dynamics, and Markov chains. Supplementary materials offer a variety of online components, including PowerPoint lecture slides for professors and MATLAB exercises.""Even though there are many dynamical systems books on the market, this book is bound to become a classic. The the

  15. Water systems

    International Nuclear Information System (INIS)

    Riess, R.

    1980-01-01

    The present paper describes the coolant chemistry and its consequences for 1300 MWsub(e) KWU PWR plants. Some selected systems, i.e. primary heat transport system, steam water cycle and cooling water arrangements, are chosen for this description. Various aspects of coolant chemistry regarding general corrosion, selective types of corrosion and deposits on heat transfer surfaces have been discussed. The water supply systems necessary to fulfill the requirements of the coolant chemistry are discussed as well. It has been concluded that a good operating performance can only be achieved when - beside other factors - the water chemistry has been given sufficient consideration. (orig./RW)

  16. Water systems

    International Nuclear Information System (INIS)

    Riess, R.

    1981-01-01

    The present paper describes the coolant chemistry and its consequences for 1300 MWsub(e) KWU PWR plants. Some selected systems, i.e. primary heat transport system, steam water cycle and cooling water arrangements, are chosen for this description. Various aspects of coolant chemistry regarding general corrosion, selective types of corrosion and deposits on heat transfer surface have been discussed. The water supply systems necessary to fulfill the requirements of the coolant chemistry are discussed as well. It has been concluded that a good operating performance can only be achieved when - beside other factors - the water chemistry has been given sufficient consideration. (orig./RW)

  17. Imaging system

    International Nuclear Information System (INIS)

    Froggatt, R.J.

    1981-01-01

    The invention provides a two dimensional imaging system in which a pattern of radiation falling on the system is detected to give electrical signals for each of a plurality of strips across the pattern. The detection is repeated for different orientations of the strips and the whole processed by compensated back projection. For a shadow x-ray system a plurality of strip x-ray detectors are rotated on a turntable. For lower frequencies the pattern may be rotated with a Dove prism and the strips condensed to suit smaller detectors with a cylindrical lens. (author)

  18. Kaonic systems

    Directory of Open Access Journals (Sweden)

    Oset E.

    2012-12-01

    Full Text Available I make a short review of the situation of the kaonic systems, with novel information supporting the two Λ(1405 states from the K-d → nπΣ reaction. A review is made of the K¯$ar K$NN system with recent calculations converging to smaller bindings and larger widths. Novel systems involving two kaons and one nucleon or three kaons are also reported and finally a short discussion is made of the analogous state DNN for which recent studies find a large binding and a small width.

  19. Software reliability and safety in nuclear reactor protection systems

    International Nuclear Information System (INIS)

    Lawrence, J.D.

    1993-11-01

    Planning the development, use and regulation of computer systems in nuclear reactor protection systems in such a way as to enhance reliability and safety is a complex issue. This report is one of a series of reports from the Computer Safety and Reliability Group, Lawrence Livermore that investigates different aspects of computer software in reactor National Laboratory, that investigates different aspects of computer software in reactor protection systems. There are two central themes in the report, First, software considerations cannot be fully understood in isolation from computer hardware and application considerations. Second, the process of engineering reliability and safety into a computer system requires activities to be carried out throughout the software life cycle. The report discusses the many activities that can be carried out during the software life cycle to improve the safety and reliability of the resulting product. The viewpoint is primarily that of the assessor, or auditor

  20. Software reliability and safety in nuclear reactor protection systems

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence, J.D. [Lawrence Livermore National Lab., CA (United States)

    1993-11-01

    Planning the development, use and regulation of computer systems in nuclear reactor protection systems in such a way as to enhance reliability and safety is a complex issue. This report is one of a series of reports from the Computer Safety and Reliability Group, Lawrence Livermore that investigates different aspects of computer software in reactor National Laboratory, that investigates different aspects of computer software in reactor protection systems. There are two central themes in the report, First, software considerations cannot be fully understood in isolation from computer hardware and application considerations. Second, the process of engineering reliability and safety into a computer system requires activities to be carried out throughout the software life cycle. The report discusses the many activities that can be carried out during the software life cycle to improve the safety and reliability of the resulting product. The viewpoint is primarily that of the assessor, or auditor.

  1. Stochastic equations for complex systems theoretical and computational topics

    CERN Document Server

    Bessaih, Hakima

    2015-01-01

    Mathematical analyses and computational predictions of the behavior of complex systems are needed to effectively deal with weather and climate predictions, for example, and the optimal design of technical processes. Given the random nature of such systems and the recognized relevance of randomness, the equations used to describe such systems usually need to involve stochastics.  The basic goal of this book is to introduce the mathematics and application of stochastic equations used for the modeling of complex systems. A first focus is on the introduction to different topics in mathematical analysis. A second focus is on the application of mathematical tools to the analysis of stochastic equations. A third focus is on the development and application of stochastic methods to simulate turbulent flows as seen in reality.  This book is primarily oriented towards mathematics and engineering PhD students, young and experienced researchers, and professionals working in the area of stochastic differential equations ...

  2. [G-DRG system 2009: relevant changes for rheumatology].

    Science.gov (United States)

    Fiori, W; Liedtke-Dyong, A; Lakomek, H-J; Buscham, K; Lehmann, H; Liman, W; Fuchs, A-K; Bessler, F; Roeder, N

    2009-08-01

    The following article presents the main general and specific changes in the G-DRG (German diagnosis-related groups) system in terms of the classification systems for diagnoses and procedures as well as the billing process for 2009. Of fundamental relevance is the national weighting of the G-DRG I97Z (complex rheumatologic treatment), which up to now had to be negotiated individually by each hospital. Emphasis is also put on case auditing by the health insurers. Being primarily a tool for redistribution of resources, every hospital has to analyze the economic effects of the 2009 G-DRG system by applying the G-DRG transition grouper to its own cases. Depending on their clinical focus rheumatological departments may experience positive or negative consequences from the development. The strain imposed on hospitals by inadequate refunding of rising costs has to be assessed separately from the effects of redistribution by the G-DRG system.

  3. A survey of manufacturers of solar thermal energy systems

    Science.gov (United States)

    Levine, N.; Slonski, M. L.

    1982-01-01

    Sixty-seven firms that had received funding for development of solar thermal energy systems (STES) were surveyed. The effect of the solar thermal technology systems program in accelerating (STES) were assessed. The 54 firms still developing STES were grouped into a production typology comparing the three major technologies with three basic functions. It was discovered that large and small firms were developing primarily central receiver systems, but also typically worked on more than one technology. Most medium-sized firms worked only on distributed systems. Federal support of STES was perceived as necessary to allow producers to take otherwise unacceptable risks. Approximately half of the respondents would drop out of STES if support were terminated, including a disproportionate number of medium-sized firms. A differentiated view of the technology, taking into account differing firm sizes and the various stages of technology development, was suggested for policy and planning purposes.

  4. Designing modular manufacturing systems using mass customisation theories and methods

    DEFF Research Database (Denmark)

    Jørgensen, Steffen Nordahl; Hvilshøj, Mads; Madsen, Ole

    2012-01-01

    Today, manufacturing systems are developed as engineered to order (ETO) solutions tailored to produce a specific product or a limited product mix. However, such dedicated systems are not consistent with the current market demands for rapid product changes, high product variety, and customisation....... In response, modular manufacturing systems (MMS) are evolving, which are aimed to possess the required responsiveness and to be the manufacturing paradigm of mass customisation (MC). Hereby, MMS brings the development process of manufacturing systems against configured to order (CTO). Up to now, research...... in MMS has primarily focused on potential benefits, basic principles, and enabling technologies, while the approaches of actually designing and creating modular architectures have received less attention. A potential to fill these gaps by applying MC theories and methods is identified based...

  5. The systems integration modeling system

    International Nuclear Information System (INIS)

    Danker, W.J.; Williams, J.R.

    1990-01-01

    This paper discusses the systems integration modeling system (SIMS), an analysis tool for the detailed evaluation of the structure and related performance of the Federal Waste Management System (FWMS) and its interface with waste generators. It's use for evaluations in support of system-level decisions as to FWMS configurations, the allocation, sizing, balancing and integration of functions among elements, and the establishment of system-preferred waste selection and sequencing methods and other operating strategies is presented. SIMS includes major analysis submodels which quantify the detailed characteristics of individual waste items, loaded casks and waste packages, simulate the detailed logistics of handling and processing discrete waste items and packages, and perform detailed cost evaluations

  6. Information management systems improve advanced plant design

    International Nuclear Information System (INIS)

    Turk, R.S.; Serafin, S.A.; Leckley, J.B.

    1994-01-01

    Computer-aided engineering tools are proving invaluable in both the design and operation of nuclear power plants. ABB Combustion Engineering's Advanced Light Water Reactor (ALWR) features a computerized Information Management System (IMS) as an integral part of the design. The System 80+IMS represents the most powerful information management tool for Nuclear Power Plants commercially available today. Developed by Duke Power Company specifically for use by nuclear power plant owner operators, the IMS consists of appropriate hardware and software to manage and control information flow for all plant related work or tasks in a systematic, consistent, coordinated and informative manner. A significant feature of this IMS is that it is primarily based on plant data. The principal design tool, PASCE (Plant Application and Systems from Combustion Engineering), is comprised of intelligent databases that describe the design and from which accurate plant drawings are created. Additionally the IMS includes, at its hub, a relational database management system and an associated document management system. The data-based approach and applications associated with the IMS were developed, and have proven highly effective, for plant modifications, configuration management, and operations and maintenance applications at Duke Power Company's operating nuclear plants. This paper presents its major features and benefits. 4 refs

  7. A polarization system for persistent chemical detection

    Science.gov (United States)

    Craven-Jones, Julia; Appelhans, Leah; Couphos, Eric; Embree, Todd; Finnegan, Patrick; Goldstein, Dennis; Karelitz, David; LaCasse, Charles; Luk, Ting S.; Mahamat, Adoum; Massey, Lee; Tanbakuchi, Anthony; Washburn, Cody; Vigil, Steven

    2015-09-01

    We report on the development of a prototype polarization tag based system for detecting chemical vapors. The system primarily consists of two components, a chemically sensitive tag that experiences a change in its optical polarization properties when exposed to a specific chemical of interest, and an optical imaging polarimeter that is used to measure the polarization properties of the tags. Although the system concept could be extended to other chemicals, for the initial system prototype presented here the tags were developed to be sensitive to hydrogen fluoride (HF) vapors. HF is used in many industrial processes but is highly toxic and thus monitoring for its presence and concentration is often of interest for personnel and environmental safety. The tags are periodic multilayer structures that are produced using standard photolithographic processes. The polarimetric imager has been designed to measure the degree of linear polarization reflected from the tags in the short wave infrared. By monitoring the change in the reflected polarization signature from the tags, the polarimeter can be used to determine if the tag was exposed to HF gas. In this paper, a review of the system development effort and preliminary test results are presented and discussed, as well as our plan for future work.

  8. Superconductor Digital-RF Receiver Systems

    Science.gov (United States)

    Mukhanov, Oleg A.; Kirichenko, Dmitri; Vernik, Igor V.; Filippov, Timur V.; Kirichenko, Alexander; Webber, Robert; Dotsenko, Vladimir; Talalaevskii, Andrei; Tang, Jia Cao; Sahu, Anubhav; Shevchenko, Pavel; Miller, Robert; Kaplan, Steven B.; Sarwana, Saad; Gupta, Deepnarayan

    Digital superconductor electronics has been experiencing rapid maturation with the emergence of smaller-scale, lower-cost communications applications which became the major technology drivers. These applications are primarily in the area of wireless communications, radar, and surveillance as well as in imaging and sensor systems. In these areas, the fundamental advantages of superconductivity translate into system benefits through novel Digital-RF architectures with direct digitization of wide band, high frequency radio frequency (RF) signals. At the same time the availability of relatively small 4K cryocoolers has lowered the foremost market barrier for cryogenically-cooled digital electronic systems. Recently, we have achieved a major breakthrough in the development, demonstration, and successful delivery of the cryocooled superconductor digital-RF receivers directly digitizing signals in a broad range from kilohertz to gigahertz. These essentially hybrid-technology systems combine a variety of superconductor and semiconductor technologies packaged with two-stage commercial cryocoolers: cryogenic Nb mixed-signal and digital circuits based on Rapid Single Flux Quantum (RSFQ) technology, room-temperature amplifiers, FPGA processing and control circuitry. The demonstrated cryocooled digital-RF systems are the world's first and fastest directly digitizing receivers operating with live satellite signals in X-band and performing signal acquisition in HF to L-band at ˜30GHz clock frequencies.

  9. Possible autocrine loop of the epidermal growth factor system in patients with benign prostatic hyperplasia treated with finasteride: a placebo-controlled randomized study

    DEFF Research Database (Denmark)

    Tørring, N.; Møller-Ernst Jensen, K.; Lund, L.

    2002-01-01

    To analyse the expression of the epidermal growth factor (EGF) system in prostate tissue and secretions obtained from patients with benign prostatic hyperplasia (BPH) treated with or without finasteride (which primarily targets the androgen-sensitive secretory epithelial cells in the prostate......, with little effect on basal epithelial and stromal cells)....

  10. Raising Job Quality and Skills for American Workers: Creating More-Effective Education and Workforce Development Systems in the States. Discussion Paper 2011-10

    Science.gov (United States)

    Holzer, Harry J.

    2011-01-01

    To improve the employment rates and earnings of Americans workers, we need to create more-coherent and more-effective education and workforce development systems, focusing primarily (though not exclusively) on disadvantaged youth and adults, and with education and training more clearly targeted towards firms and sectors that provide good-paying…

  11. The interplay of institutions, actors and technologies in socio-technical systems - An analysis of transformations in the Australian urban water sector

    NARCIS (Netherlands)

    Fuenfschilling, Lea; Truffer, Bernhard

    2016-01-01

    Literature on socio-technical transitions has primarily emphasized the co-determination of institutions and technologies. In this paper, we want to focus on how actors play a mediating role between these two pillars of a socio-technical system. By introducing the theoretical concept of institutional

  12. Toxicities of systemic agents in squamous cell carcinoma of the head and neck (SCCHN); A new perspective in the era of immunotherapy

    NARCIS (Netherlands)

    Saba, N.F.; Mody, M.D.; Tan, E.S.; Gill, H.S.; Rinaldo, A.; Takes, R.P.; Strojan, P.; Hartl, D.M.; Vermorken, J.B.; Haigentz, M., Jr.; Ferlito, A.

    2017-01-01

    Squamous cell carcinoma of the head and neck (SCCHN) is a difficult to treat malignancy and represents the seventh most common cancer worldwide. Systemic therapy has a critical role in the treatment of locally advanced and recurrent/metastatic disease. Cytotoxic chemotherapy has been primarily used

  13. Exploring Three-Phase Systems and Synchronous Motors: A Low-Voltage and Low-Cost Experiment at the Sophomore Level

    Science.gov (United States)

    Schubert, T. F., Jr.; Jacobitz, F. G.; Kim, E. M.

    2011-01-01

    In order to meet changing curricular and societal needs, a three-phase system and synchronous motor laboratory experience for sophomore-level students in a wide variety of engineering majors was designed, implemented, and assessed. The experiment is unusual in its early placement in the curriculum, and in that it focuses primarily on basic…

  14. On-line reputation systems : the effects of feedback comments and reactions on building and rebuilding trust in on-line auctions

    NARCIS (Netherlands)

    Utz, S.; Matzat, U.; Snijders, C.C.P.

    2009-01-01

    Previous research on reputation systems primarily focused on their trust-building function. The present research addresses their trust-rebuilding function-specifically, the role of the short text comments given in reaction to negative feedback. Rebuilding trust is often necessary because on-line

  15. ring system

    African Journals Online (AJOL)

    1,3,2-DIAZABORACYCLOALKANE. RING SYSTEM. Negussie Retta" and Robert H. Neilson. 'Department of Chemistry, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia. Department of Chemistry, Texas Christian University.

  16. Septic Systems

    Science.gov (United States)

    The web site provides guidance and technical assistance for homeowners, government officials, industry professionals, and EPA partners about how to properly develop and manage individual onsite and community cluster systems that treat domestic wastewater.

  17. Respiratory system

    Science.gov (United States)

    Bartlett, R. G., Jr.

    1973-01-01

    The general anatomy and function of the human respiratory system is summarized. Breathing movements, control of breathing, lung volumes and capacities, mechanical relations, and factors relevant to respiratory support and equipment design are discussed.

  18. Bubble systems

    CERN Document Server

    Avdeev, Alexander A

    2016-01-01

    This monograph presents a systematic analysis of bubble system mathematics, using the mechanics of two-phase systems in non-equilibrium as the scope of analysis. The author introduces the thermodynamic foundations of bubble systems, ranging from the fundamental starting points to current research challenges. This book addresses a range of topics, including description methods of multi-phase systems, boundary and initial conditions as well as coupling requirements at the phase boundary. Moreover, it presents a detailed study of the basic problems of bubble dynamics in a liquid mass: growth (dynamically and thermally controlled), collapse, bubble pulsations, bubble rise and breakup. Special emphasis is placed on bubble dynamics in turbulent flows. The analysis results are used to write integral equations governing the rate of vapor generation (condensation) in non-equilibrium flows, thus creating a basis for solving a number of practical problems. This book is the first to present a comprehensive theory of boil...

  19. Systems Biology

    Indian Academy of Sciences (India)

    IAS Admin

    study and understand the function of biological systems, particu- larly, the response of such .... understand the organisation and behaviour of prokaryotic sys- tems. ... relationship of the structure of a target molecule to its ability to bind a certain ...

  20. MACRO1: a code to test a methodology for analyzing nuclear-waste management systems

    International Nuclear Information System (INIS)

    Edwards, L.L.

    1979-01-01

    The code is primarily a manager of probabilistic data and deterministic mathematical models. The user determines the desired aggregation of the available models into a composite model of a physical system. MACRO1 then propagates the finite probability distributions of the inputs to the model to finite probability distributions over the outputs. MACRO1 has been applied to a sample analysis of a nuclear-waste repository, and its results compared satisfactorily with previously obtained Monte Carlo statistics

  1. Emergency Based Remote Collateral Tracking System Using Google's Android Mobile Platform

    OpenAIRE

    Ramalingam, Ashokkumar; Dorairaj, Prabhu; Ramamoorthy, Saranya

    2011-01-01

    Introduction of Smart phones redefined the usage of mobile phones in the communication world. Smart phones are equipped with various sophisticated features such as Wi-Fi, GPS navigation, high resolution camera, touch screen with broadband access which helps the mobile phone users to keep in touch with the modern world. Many of these features are primarily integrated with the mobile operating system which is out of reach to public, by which the users can’t manipulate those features. Google cam...

  2. NJOY. A comprehensive system for the processing of ENDF formatted nuclear data

    International Nuclear Information System (INIS)

    Muir, D.W.

    1990-07-01

    An introduction to the program system NJOY is given which processes data files of evaluated neutron nuclear data coded in ENDF format. NJOY is primarily used for neutron and photon transport calculations for nuclear power reactor design. The NJOY code is not available from the IAEA Nuclear Data Section but may be obtained from the Reactor Shielding Information Center, Oak Ridge, USA. (author). 10 refs, 1 fig

  3. CRBRP design and test results for fuel handling systems, plugs, and seals

    International Nuclear Information System (INIS)

    Berg, G.E.

    1977-01-01

    The fuel handling system and reactor rotating plugs for the Clinch River Breeder Reactor Plant (CRBRP) are based primarily on existing technology and, in many respects, follow the concept developed for the Fast Flux Test Facility (FFTF). The equipment and the development programs initiated to verify its performance are described. Test results obtained from the development program, and the extent to which these results verified original design selections, or suggested potential improvements, are discussed

  4. Non-Destructive Damping Measurement for Wafer-Level Packaged Microelectromechanical System (MEMS) Acceleration Switches

    Science.gov (United States)

    2014-09-01

    small geometries and inertial forces are often negligible, so the behavior of fluids is based primarily on the viscous effects.3 Experimental...system modeling. In isolated environments filled with a working fluid that dissipates energy, damping between parallel and sliding plates that are... damper in a second-order differential equation. Fig. 1 Example of the data taken by the data acquisition device The impact table will produce high

  5. Bolts from Orion: Destroying Mobile Surface-to-Air Missile Systems with Lethal Autonomous Aircraft

    Science.gov (United States)

    2016-07-01

    After the Vietnam War, the Israeli Air Force used the versatile Lighting Bug as the basis to develop an RPA to help find and destroy Egyptian SAM...RPA development. The focus is primarily on common control systems and a joint control architecture ,73 which will ensure common traits between both...time the Air Force develops new technology it is expensive, but switching to open architectures that allow easy technology sharing across airframes

  6. A framework for implementing a Distributed Intrusion Detection System (DIDS) with interoperabilty and information analysis

    OpenAIRE

    Davicino, Pablo; Echaiz, Javier; Ardenghi, Jorge Raúl

    2011-01-01

    Computer Intrusion Detection Systems (IDS) are primarily designed to protect availability, condentiality and integrity of critical information infrastructures. A Distributed IDS (DIDS) consists of several IDS over a large network(s), all of which communicate with each other, with a central server or with a cluster of servers that facilitates advanced network monitoring. In a distributed environment, DIDS are implemented using cooperative intelligent sensors distributed across the network(s). ...

  7. An Operators View of Reliability Testing and Decay Heat Rejection Systems

    International Nuclear Information System (INIS)

    Henderson, J.D.C.

    1975-01-01

    The object of this paper is to review the in-situ testing of DHR systems, and to convey policy rather than to indicate a definitive test programme. The test policy is aimed primarily at commissioning the plant and secondly at providing such support for reliability predictions as is practical. Provisions for removal of decay heat from the core and from the reactor tank are described in papers by Broadley and Davies

  8. The MIT Lincoln Laboratory RT-04F Diarization Systems: Applications to Broadcast Audio and Telephone Conversations

    Science.gov (United States)

    2004-11-01

    this paper we describe the systems developed by MITLL and used in DARPA EARS Rich Transcription Fall 2004 (RT-04F) speaker diarization evaluation...many types of audio sources, the focus if the DARPA EARS project and the NIST Rich Transcription evaluations is primarily speaker diarization ...present or samples of any of the speakers . An overview of the general diarization problem and approaches can be found in [1]. In this paper, we

  9. Pathways for Small Molecule Delivery to the Central Nervous System Across the Blood-Brain Barrier

    OpenAIRE

    Mikitsh, John L; Chacko, Ann-Marie

    2014-01-01

    The treatment of central nervous system (CNS) disease has long been difficult due to the ineffectiveness of drug delivery across the blood-brain barrier (BBB). This review summarizes important concepts of the BBB in normal versus pathophysiology and how this physical, enzymatic, and efflux barrier provides necessary protection to the CNS during drug delivery, and consequently treatment challenging. Small molecules account for the vast majority of available CNS drugs primarily due to their abi...

  10. Management Control in Enterprise System Enabled Organizations: A Literature Review

    DEFF Research Database (Denmark)

    Rikhardsson, Pall M.; Rohde, C.; Rom, A.

    2006-01-01

    The objective of this paper is to add to the limited body of knowledge on the relationship between enterprise systems (ES) and management control. Based on a literature review, we describe and classify studies that empirically address this relationship. Apart from not being extensive, the research...... done so far primarily addresses the relationship between management control and ES based on a limited number of methodologies and approaches. We argue that there seems to be a need for more research done from functionalistic and critical perspectives, as well which employs a greater variety...

  11. Advanced hybrid and electric vehicles system optimization and vehicle integration

    CERN Document Server

    2016-01-01

    This contributed volume contains the results of the research program “Agreement for Hybrid and Electric Vehicles”, funded by the International Energy Agency. The topical focus lies on technology options for the system optimization of hybrid and electric vehicle components and drive train configurations which enhance the energy efficiency of the vehicle. The approach to the topic is genuinely interdisciplinary, covering insights from fields. The target audience primarily comprises researchers and industry experts in the field of automotive engineering, but the book may also be beneficial for graduate students.

  12. Testing space weather connections in the solar system

    Science.gov (United States)

    Grison, B.; Souček, J.; Krupař, V.; Píša, D.; Santolík, O.; Taubenschuss, U.; Němec, F.

    2017-09-01

    This study aims at testing and validating tools for prediction of the impact of solar events in the vicinity of inner and outer solar system planets using in-situ spacecraft data (primarily MESSENGER, STEREO and ACE, but also VEX and Cassini), remote Jovian observations (Hubble telescope, Nançay decametric array), existing catalogues (HELCATS and Tao et al. (2005)) and the tested propagating models (the ICME radial propagation tool of the CDPP and the 1-D MHD code propagation model presented in Tao et al. (2005)).

  13. Pilot interaction with automated airborne decision making systems

    Science.gov (United States)

    Hammer, John M.; Wan, C. Yoon; Vasandani, Vijay

    1987-01-01

    The current research is focused on detection of human error and protection from its consequences. A program for monitoring pilot error by comparing pilot actions to a script was described. It dealt primarily with routine errors (slips) that occurred during checklist activity. The model to which operator actions were compared was a script. Current research is an extension along these two dimensions. The ORS fault detection aid uses a sophisticated device model rather than a script. The newer initiative, the model-based and constraint-based warning system, uses an even more sophisticated device model and is to prevent all types of error, not just slips or bad decision.

  14. BOA: Asbestos Pipe-Insulation Abatement Robot System

    International Nuclear Information System (INIS)

    Schempf, H.

    1996-01-01

    The BOA system is a mobile pipe-external robotic crawler used to remotely strip and bag asbestos-containing lagging and insulation materials (ACLIM) from various diameter pipes in (primarily) industrial installations. Steam and process lines within the DOE weapons complex warrant the use of a remote device due to the high labor costs and high level of radioactive contamination, making manual removal extremely costly and highly inefficient. Currently targeted facilities for demonstration and remediation are Fernald in Ohio and Oak Ridge in Tennessee

  15. BOA: Pipe-asbestos insulation removal robot system

    Energy Technology Data Exchange (ETDEWEB)

    Schempf, H.; Bares, J.; Schnorr, W. [Carnegie Mellon Univ., Pittsburgh, PA (United States)

    1995-10-01

    The BOA system is a mobile pipe-external robotic crawler used to remotely strip and bag asbestos-containing lagging and insulation materials (ACLIM) from various diameter pipes in (primarily) industrial installations. Steam and process lines within the DOE weapons complex warrant the use of a remote device due to the high labor costs and high level of radioactive contamination, making manual removal extremely costly and highly inefficient. Currently targeted facilities for demonstration and remediation are Fernald in Ohio and Oak Ridge in Tennessee.

  16. BOA: Pipe-asbestos insulation removal robot system

    International Nuclear Information System (INIS)

    Schempf, H.; Bares, J.; Schnorr, W.

    1995-01-01

    The BOA system is a mobile pipe-external robotic crawler used to remotely strip and bag asbestos-containing lagging and insulation materials (ACLIM) from various diameter pipes in (primarily) industrial installations. Steam and process lines within the DOE weapons complex warrant the use of a remote device due to the high labor costs and high level of radioactive contamination, making manual removal extremely costly and highly inefficient. Currently targeted facilities for demonstration and remediation are Fernald in Ohio and Oak Ridge in Tennessee

  17. Design of optoelectronic system for optical diffusion tomography

    Directory of Open Access Journals (Sweden)

    Erakhtin Igor

    2017-01-01

    Full Text Available This article explores issues connected with the circuit design of a device for optical diffusion tomography, which we are currently designing. We plan to use the device in experimental studies for the development of a faster method of brain hematoma detection. We reviewed currently existing methods for emergency diagnosis of hematomas, primarily the Infrascanner model 2000, for which we identified weaknesses, and outlined suggestions for improvements. This article describes the method of scanning tissues based on a triangulated arrangement of sources and receivers of optical radiation, and it discusses the optoelectronic system that implements that principle.

  18. Bricks / Systems

    DEFF Research Database (Denmark)

    At first glance, this book may appear eclectic. It contains writings from architectural practice in a language and structure based on subjective views and experiences, combined with research contributions based on systematic design investigations of discrete computational systems. Discussions range......, and it aims to illustrate and identify new modes of working in architecture, particularly with regards to brickwork and other complex systems of modular assemblies, whether physical or digital....

  19. Expert Systems

    OpenAIRE

    Lucas, P.J.F.

    2005-01-01

    Expert systems mimic the problem-solving activity of human experts in specialized domains by capturing and representing expert knowledge. Expert systems include a knowledge base, an inference engine that derives conclusions from the knowledge, and a user interface. Knowledge may be stored as if-then rules, orusing other formalisms such as frames and predicate logic. Uncertain knowledge may be represented using certainty factors, Bayesian networks, Dempster-Shafer belief functions, or fuzzy se...

  20. Management Principles to be Considered for Implementing a Data Base Management System Aboard U.S. (United States) Naval Ships under the Shipboard Non-Tactical ADP (Automated Data Processing) Program.

    Science.gov (United States)

    1982-12-01

    addressed later) in a reliable condition. As indicated ab ¢- , the :.-n to f zago the imp!men- tation of a Data Base Managemenz System (DBMS) with S IAP was...justified through cost reductions based on personnel placement. M anagement must zoncentrats primarily on i-dentifying the infcrmatioa it needs to...systems.4 6: ID/21] DIta Base Management Systems (DBMSs) Are more compatible with I. M and DDS. than traditional file iianagement systems used in the