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Sample records for single turn extraction

  1. Assessment of single-turn extraction for a superconducting separated-sector cyclotron

    Directory of Open Access Journals (Sweden)

    J.-W. Kim

    1999-04-01

    Full Text Available We have studied the beam dynamics in a high field separated-sector cyclotron to establish conditions required to achieve single-turn extraction. Extraction efficiency above 99% is aimed to avoid beam-induced damages. A sufficient last-turn separation and a preservation of beam quality throughout the acceleration are the prerequisites. The last-turn separation can be enhanced with the orbital precession induced by an off-centering injection as in existent lower field separated-sector cyclotrons. The beam qualities, on the other hand, are affected by the resonances traversed or approached during the acceleration. Acceleration of light nuclei to the energies of 300–400 MeV/u was especially disturbing because of the broadening of radial beamwidth upon crossing the ν_{r}=3/2 resonance. Tolerance to the third harmonic gradient field, which causes the resonance in lowest order, is set to be 0.1 G/cm. The integer resonance ν_{z}=1 can be avoided with a proper design of the yoke. The longitudinal space charge forces were also investigated to estimate the intensity limits determined by the energy spreads of beam assuming simplified charge distributions. Moreover, beam preparations for injection matching are described in view of reducing the beam losses into the extraction elements.

  2. Diamond turning of Si and Ge single crystals

    Energy Technology Data Exchange (ETDEWEB)

    Blake, P.; Scattergood, R.O.

    1988-12-01

    Single-point diamond turning studies have been completed on Si and Ge crystals. A new process model was developed for diamond turning which is based on a critical depth of cut for plastic flow-to-brittle fracture transitions. This concept, when combined with the actual machining geometry for single-point turning, predicts that {open_quotes}ductile{close_quotes} machining is a combined action of plasticity and fracture. Interrupted cutting experiments also provide a meant to directly measure the critical depth parameter for given machining conditions.

  3. Geometry of single-point turning tools and drills

    CERN Document Server

    Astakhov, Viktor P

    2010-01-01

    Tools for metal cutting have many shapes and features, each of which is described by its angles or geometries. The selection of the right cutting tool geometry is critical because it directly affects the integrity of the machined surface, tool life, power needed for machining, and thus the overall machining efficiency. ""Geometry of Single-Point Turning Tools and Drills"" outlines clear objectives of cutting tool geometry selection and optimization, using multiple examples to provide a thorough explanation. The establishment of clear bridges between cutting theory, tool geometry, and shop prac

  4. Single-Mode WGM Resonators Fabricated by Diamond Turning

    Science.gov (United States)

    Grudinin, Ivan; Maleki, Lute; Savchenkov, Anatoliy; Matsko, Andrewy; Strekalov, Dmitry; Iltchenko, Vladimir

    2008-01-01

    A diamond turning process has made possible a significant advance in the art of whispering-gallery-mode (WGM) optical resonators. By use of this process, it is possible to fashion crystalline materials into WGM resonators that have ultrahigh resonance quality factors (high Q values), are compact (ranging in size from millimeters down to tens of microns), and support single electromagnetic modes. This development combines and extends the developments reported in "Few- Mode Whispering-Gallery-Mode Resonators" (NPO-41256), NASA Tech Briefs, Vol. 30, No. 1 (January 2006), page 16a and "Fabrication of Submillimeter Axisymmetric Optical Components" (NPO-42056), NASA Tech Briefs, Vol. 31, No. 5 (May 2007), page 10a. To recapitulate from the first cited prior article: A WGM resonator of this special type consists of a rod, made of a suitable transparent material, from which protrudes a thin circumferential belt of the same material. The belt is integral with the rest of the rod and acts as a circumferential waveguide. If the depth and width of the belt are made appropriately small, then the belt acts as though it were the core of a single-mode optical fiber: the belt and the rod material adjacent to it support a single, circumferentially propagating mode or family of modes. To recapitulate from the second cited prior article: A major step in the fabrication of a WGM resonator of this special type is diamond turning or computer numerically controlled machining of a rod of a suitable transparent crystalline material on an ultrahigh-precision lathe. During the rotation of a spindle in which the rod is mounted, a diamond tool is used to cut the rod. A computer program is used to control stepping motors that move the diamond tool, thereby controlling the shape cut by the tool. Because the shape can be controlled via software, it is possible to choose a shape designed to optimize a resonator spectrum, including, if desired, to limit the resonator to supporting a single mode

  5. First Results for the Beam Commissioning of the CERN Multi-Turn Extraction

    CERN Document Server

    Gilardoni, S; Benedetto, E; Bohl, T; Cettour Cave, S; Cornelis, K; Damerau, H; Follin, F; Fowler, T; Franchi, A; Freyermuth, P; Genoud, H; Giachino, R; Giovannozzi, M; hancock, S; Le Borgne, Y; Manglunki, D; Métral, G; Pereira, L; Ridewood, J; Riva, Y; Schokker, M; Sermeus, L; Steerenberg, R; Vandorpe, B; Wenninger, J

    2010-01-01

    The Multi-Turn Extraction (MTE), a new type of extraction based on beam trapping inside stable islands in horizontal phase space, has been commissioned during the 2008 run of the CERN Proton Synchrotron. Both singleand multi-bunch beams with a total intensity up to 1.4 1013 protons have been extracted with efficiencies up to 98%. Furthermore, injection tests in the CERN Super Proton Synchrotron were performed, with the beam then accelerated and extracted to produce neutrinos for the CERN Neutrino-to-Gran Sasso experiments. The results of the extensive measurement campaign are presented and discussed in detail.

  6. Transverse beam splitting made operational: Recent progress of the multi-turn extraction at the CERN proton synchrotron

    CERN Document Server

    AUTHOR|(CDS)2082016; Borburgh, Jan; Damjanovic, Sanja; Gilardoni, Simone; Giovannozzi, Massimo; Hourican, Michael; Kahle, Karsten; Michels, Olivier; Sterbini, Guido; Hernalsteens, Cedric; Le Godec, Gilles

    2016-01-01

    Following a successful commissioning period, the Multi-Turn Extraction (MTE) at the CERN Proton Synchrotron (PS) has been applied for the fixed-target physics programme at the Super Proton Synchrotron (SPS) since September 2015. This exceptional extraction technique was proposed to replace the long-serving Continuous Transfer (CT) extraction, which has the drawback of inducing high activation in the ring. MTE exploits the principles of non-linear beam dynamics to perform loss-free beam splitting in the horizontal phase space. Over multiple turns, the resulting beamlets are then transferred to the downstream accelerator. The operational deployment of MTE was rendered possible by the full understanding and mitigation of different hardware limitations and by redesigning the extraction trajectories and non-linear optics, which was required due to the installation of a dummy septum to reduce the activation of the magnetic extraction septum. The results of the related experimental and simulation studies, a summary ...

  7. An application of eddy current damping effect on single point diamond turning of titanium alloys

    Science.gov (United States)

    Yip, W. S.; To, S.

    2017-11-01

    Titanium alloys Ti6Al4V (TC4) have been popularly applied in many industries. They have superior material properties including an excellent strength-to-weight ratio and corrosion resistance. However, they are regarded as difficult to cut materials; serious tool wear, a high level of cutting vibration and low surface integrity are always involved in machining processes especially in ultra-precision machining (UPM). In this paper, a novel hybrid machining technology using an eddy current damping effect is firstly introduced in UPM to suppress machining vibration and improve the machining performance of titanium alloys. A magnetic field was superimposed on samples during single point diamond turning (SPDT) by exposing the samples in between two permanent magnets. When the titanium alloys were rotated within a magnetic field in the SPDT, an eddy current was generated through a stationary magnetic field inside the titanium alloys. An eddy current generated its own magnetic field with the opposite direction of the external magnetic field leading a repulsive force, compensating for the machining vibration induced by the turning process. The experimental results showed a remarkable improvement in cutting force variation, a significant reduction in adhesive tool wear and an extreme long chip formation in comparison to normal SPDT of titanium alloys, suggesting the enhancement of the machinability of titanium alloys using an eddy current damping effect. An eddy current damping effect was firstly introduced in the area of UPM to deliver the results of outstanding machining performance.

  8. An application of eddy current damping effect on single point diamond turning of titanium alloys

    International Nuclear Information System (INIS)

    Yip, W S; To, S

    2017-01-01

    Titanium alloys Ti6Al4V (TC4) have been popularly applied in many industries. They have superior material properties including an excellent strength-to-weight ratio and corrosion resistance. However, they are regarded as difficult to cut materials; serious tool wear, a high level of cutting vibration and low surface integrity are always involved in machining processes especially in ultra-precision machining (UPM). In this paper, a novel hybrid machining technology using an eddy current damping effect is firstly introduced in UPM to suppress machining vibration and improve the machining performance of titanium alloys. A magnetic field was superimposed on samples during single point diamond turning (SPDT) by exposing the samples in between two permanent magnets. When the titanium alloys were rotated within a magnetic field in the SPDT, an eddy current was generated through a stationary magnetic field inside the titanium alloys. An eddy current generated its own magnetic field with the opposite direction of the external magnetic field leading a repulsive force, compensating for the machining vibration induced by the turning process. The experimental results showed a remarkable improvement in cutting force variation, a significant reduction in adhesive tool wear and an extreme long chip formation in comparison to normal SPDT of titanium alloys, suggesting the enhancement of the machinability of titanium alloys using an eddy current damping effect. An eddy current damping effect was firstly introduced in the area of UPM to deliver the results of outstanding machining performance. (paper)

  9. Surface finish in ultra-precision diamond turning of single-crystal silicon

    Science.gov (United States)

    Ayomoh, M.; Abou-El-Hossein, K.

    2015-10-01

    Silicon is an optical material widely used in the production of infrared optics. However, silicon as a brittle material exhibits some difficulties when ultra-precision machined by mono-crystalline single point diamond. Finish turning of silicon with mono- crystalline diamond inserts results in accelerated tool wear rates if the right combination of the machining parameters is not properly selected. In this study, we conducted a series of machining tests on an ultra-high precision machine tool using finish turning conditions when using mono-crystalline diamond inserts with negative rake angle and relatively big nose radius. The study yields some recommendations on the best combination of machining parameters that will result in maximum material removal rates with smallest possible surface finish. In this work, standard non-controlled waviness diamond inserts having nose radius of about 1.5 mm, rake angle of negative 25°, and clearance angle of 5° were used to produce flat surfaces on silicon disk. From the results, it has been established that feed rate has the most influential effect followed by the depth of cut and cutting speed.

  10. Optics measurements and transfer line matching for the SPS injection of the CERN Multi-Turn Extraction beam

    CERN Document Server

    Benedetto, E; Cettour Cave, S; Follin, F; Gilardoni, S; Giovannozzi, M; Roncarolo, F

    2010-01-01

    Dispersion and beam optics measurements were carried out in the transfer line between the CERN PS and SPS for the new Multi-Turn Extraction beam. Since the extraction conditions of the four islands and the core are different and strongly dependent on the non-linear effects used to split the beam in the transverse plane, a special care was taken during the measurement campaigns. Furthermore, an appropriate strategy was devised to minimize the overall optical mismatch at SPS injection. All this led to a new optical configuration that will be presented in the paper.

  11. Extractables analysis of single-use flexible plastic biocontainers.

    Science.gov (United States)

    Marghitoiu, Liliana; Liu, Jian; Lee, Hans; Perez, Lourdes; Fujimori, Kiyoshi; Ronk, Michael; Hammond, Matthew R; Nunn, Heather; Lower, Asher; Rogers, Gary; Nashed-Samuel, Yasser

    2015-01-01

    Studies of the extractable profiles of bioprocessing components have become an integral part of drug development efforts to minimize possible compromise in process performance, decrease in drug product quality, and potential safety risk to patients due to the possibility of small molecules leaching out from the components. In this study, an effective extraction solvent system was developed to evaluate the organic extractable profiles of single-use bioprocess equipment, which has been gaining increasing popularity in the biopharmaceutical industry because of the many advantages over the traditional stainless steel-based bioreactors and other fluid mixing and storage vessels. The chosen extraction conditions were intended to represent aggressive conditions relative to the application of single-use bags in biopharmaceutical manufacture, in which aqueous based systems are largely utilized. Those extraction conditions, along with a non-targeted analytical strategy, allowed for the generation and identification of an array of extractable compounds; a total of 53 organic compounds were identified from four types of commercially available single-use bags, the majority of which are degradation products of polymer additives. The success of this overall extractables analysis strategy was reflected partially by the effectiveness in the extraction and identification of a compound that was later found to be highly detrimental to mammalian cell growth. The usage of single-use bioreactors has been increasing in biopharmaceutical industry because of the appealing advantages that it promises regarding to the cleaning, sterilization, operational flexibility, and so on, during manufacturing of biologics. However, compared to its conventional counterparts based mainly on stainless steel, single-use bioreactors are more susceptible to potential problems associated with compound leaching into the bioprocessing fluid. As a result, extractable profiling of the single-use system has become

  12. Results from the 2009 beam commissioning of the CERN multi-turn extraction

    CERN Document Server

    Benedetto, E; Bohl, T; Cettour Cave, S; Cornelis, K; Cotte, D; Damerau, H; Delrieux, M; Fleuret, J; Fowler, T; Follin, F; Franchi, A; Freyermuth, P; Genoud, H; Gilardoni, S; Giovannozzi, M; Hancock, S; Hans, O; Le Borgne, Y; Manglunki, D; Matli, E; Métral, E; Métral, G; Newman, M; Pereira, L; Peters, F; Riva, Y; Roncarolo, F; Sermeus, L; Steerenberg, R; Vandorpe, B; Wenninger, J

    2010-01-01

    Following the analysis of the results obtained during the first year of beam commissioning of the CERN multiturn extraction, a number of changes have been introduced in the beam manipulations performed in the CERN Proton Synchrotron. This includes a different control of the linear chromaticity, the setting of the nonlinear magnets used to split the beam, and the longitudinal structure in the PS. The results obtained during the 2009 run are presented and discussed in detail, including the beam performance in both the PS and the SPS.

  13. Turn-off failure in multi-finger SOI-LIGBT used for single chip inverter ICs

    Science.gov (United States)

    Zhang, Long; Zhu, Jing; Zhao, Minna; Huang, Xuequan; Chen, Jiajun; Sun, Weifeng; Ding, Desheng

    2017-11-01

    In this paper, the clamped inductive turn-off failure of the Silicon-on-Insulator Lateral Insulated Gate Bipolar Transistor (SOI-LIGBT) with multiple fingers under high-voltage and high-current conditions is investigated. First, the measured turn-off waveforms combining with the on-state I-V characteristics of the failed device are discussed to distinguish the probable cause of the failure. Then, two-dimensional (2-D) electrothermal simulations are performed to reproduce the failure by using Sentaurus TCAD. The failure is originated from an inhomogeneous depletion behavior among the paralleled fingers during the turn-off, which gives rise to the non-uniform current-sharing and the subsequent current crowding in single finger. As a result, the latch-up of the device takes place. The simulation indicates that the current crowding is formed mainly through an internal path in the silicon. In order to verify the failure mechanism, an improved device with deep-oxide trenches arranged between the adjacent fingers is fabricated. The measured results demonstrate that no failure occurs when the improved device turns off under high-voltage and high-current conditions.

  14. Moving Target Information Extraction Based on Single Satellite Image

    Directory of Open Access Journals (Sweden)

    ZHAO Shihu

    2015-03-01

    Full Text Available The spatial and time variant effects in high resolution satellite push broom imaging are analyzed. A spatial and time variant imaging model is established. A moving target information extraction method is proposed based on a single satellite remote sensing image. The experiment computes two airplanes' flying speed using ZY-3 multispectral image and proves the validity of spatial and time variant model and moving information extracting method.

  15. Ultrasonically Assisted Single Point Diamond Turning of Optical Mold of Tungsten Carbide

    Directory of Open Access Journals (Sweden)

    Zhanjie Li

    2018-02-01

    Full Text Available To realize high efficiency, low/no damage and high precision machining of tungsten carbide used for lens mold, a high frequency ultrasonic vibration cutting system was developed at first. Then, tungsten carbide was precisely machined with a polycrystalline diamond (PCD tool assisted by the self-developed high frequency ultrasonic vibration cutting system. Tool wear mechanism was investigated in ductile regime machining of tungsten carbide. The cutter back-off phenomenon in the process was analyzed. The subsequent experimental results of ultra-precision machining with a single crystal diamond tool showed that: under the condition of high frequency ultrasonic vibration cutting, nano-scale surface roughness can be obtained by the diamond tool with smaller tip radius and no defects like those of ground surface were found on the machined surface. Tool wear mechanisms of the single crystal diamond tool are mainly abrasive wear and micro-chipping. To solve the problem, a method of inclined ultrasonic vibration cutting with negative rake angle was put forward according to force analysis, which can further reduce tool wear and roughness of the machined surface. The investigation was important to high efficiency and quality ultra-precision machining of tungsten carbide.

  16. Coumarins as turn on/off fluorescent probes for detection of residual acetone in cosmetics following headspace single-drop microextraction.

    Science.gov (United States)

    Cabaleiro, N; de la Calle, I; Bendicho, C; Lavilla, I

    2014-11-01

    In this work, a new method based on headspace-single drop microextraction for the determination of residual acetone in cosmetics by microfluorospectrometry is proposed. Acetone causes fluorescence changes in a 2.5 µL-ethanolic drop (40% v/v) containing 3.10(-4) mol L(-1) 7-hydroxy-4-methylcoumarin ('turn off') or 6.10(-6) mol L(-1) 7-diethylamino-4-methylcoumarin ('turn on'). Polarity and ability to form hydrogen bonds of short chain alcohols (polar protic solvents) were crucial in order to observe these changes in the presence of acetone (polar aprotic solvent). Parameters related with the HS-SDME procedure were studied, namely headspace volume, composition, volume and temperature of drop, microextraction time, stirring rate, mass and temperature of sample, as well as the effect of potential interferents (alcohols and fragrances). The high volatility of acetone allows its extraction from an untreated cosmetic sample within 3 min. A detection limit of 0.26 µg g(-1) and repeatability, expressed as relative standard deviation, around 5% were reached. Accuracy of the proposed methodology was evaluated by means of recovery studies. The method was successfully used to analyze different cosmetics. Simplicity and high sample throughput can be highlighted. Copyright © 2014 Elsevier B.V. All rights reserved.

  17. Single-shot work extraction in quantum thermodynamics revisited

    Science.gov (United States)

    Wang, Shang-Yung

    2018-01-01

    We revisit the problem of work extraction from a system in contact with a heat bath to a work storage system, and the reverse problem of state formation from a thermal system state in single-shot quantum thermodynamics. A physically intuitive and mathematically simple approach using only elementary majorization theory and matrix analysis is developed, and a graphical interpretation of the maximum extractable work, minimum work cost of formation, and corresponding single-shot free energies is presented. This approach provides a bridge between two previous methods based respectively on the concept of thermomajorization and a comparison of subspace dimensions. In addition, a conceptual inconsistency with regard to general work extraction involving transitions between multiple energy levels of the work storage system is clarified and resolved. It is shown that an additional contribution to the maximum extractable work in those general cases should be interpreted not as work extracted from the system, but as heat transferred from the heat bath. Indeed, the additional contribution is an artifact of a work storage system (essentially a suspended ‘weight’ that can be raised or lowered) that does not truly distinguish work from heat. The result calls into question the common concept that a work storage system in quantum thermodynamics is simply the quantum version of a suspended weight in classical thermodynamics.

  18. Engineering design and integration of in-vessel single turn segmental coil in vacuum vessel of SST-1

    Science.gov (United States)

    Jayswal, Snehal; Chauhan, P.; Santra, P.; Vasava, K.; Perekh, T.; Patel, H.; Biswas, P.; Pradhan, S.

    2017-04-01

    SST-1 tokamak is having the error field due to unsymmetrical positioning of Toroidal field coils which push the plasma to inner side from its major radius of 1100 mm. hence it is required to install the In-vessel Coil (PF6) at a location of 1350 mm radius and elevation of 350 mm above and below the mid plane of the toroidal field coils. The In-Vessel coil was decided to make in eight segments for futuristic use, to control the individual localized error field correction by supplying the different current. A single turn, eight segments, copper conductor with 18 mm diameter with GFRP insulation and in housed in SS304 L casing to carry 8000 A current for 10 s was designed and installed in vacuum vessel of SST-1. This paper will present the design drivers, material selection, advantages and constraints of the in-vessel coils, its conceptual and engineering design, CAD models, finite element analysis using ANSYS, its fabrication, quality assurance/control and assembly/integration aspects inside vacuum vessel of SST-1.

  19. Immediate loading with single-piece implant following extraction

    Directory of Open Access Journals (Sweden)

    Hemlata Dwivedi

    2017-01-01

    Full Text Available Although dental implantology had evolved over a number of years, many dental surgeons are unaware of the concept of immediate loading with the use of one-piece implant that began in the early 1960s. The goal of successful prosthodontics rehabilitation is to provide function, esthetics, and comfort to the patient. The aim of this literature is to provide an overview of one-piece implant, with its advantages and disadvantages over conventional two-piece implant. Immediate prosthetic of a one-piece system allows for a better tissue healing and better adhesion of gingival mucosa to form a collar which is healthy and adherent to the implant, avoiding a second surgical procedure, and also includes a very important aspect esthetics. This article describes a case report of immediate loading with single-piece implant following extraction.

  20. Lasing thresholds of helical photonic structures with different positions of a single light-amplifying helix turn

    Energy Technology Data Exchange (ETDEWEB)

    Blinov, L M; Palto, S P [A.V. Shubnikov Institute of Crystallography, Russian Academy of Sciences, Moscow, Russian Federaion (Russian Federation)

    2013-09-30

    Numerical simulation is used to assess the lasing threshold of helical structures of cholesteric liquid crystals (CLCs) in which only one turn amplifies light. This turn is located either in the centre of symmetric structures of various sizes or in an arbitrary place in asymmetric structures of preset size. In all cases, we find singularities in light amplification by a one-dimensional CLC structure for the most important band-edge modes (m1, m2 and m3) and plot the threshold gain coefficient k{sub th} against the position of the amplifying turn. For the symmetric structures, the lasing threshold of the m1 mode is shown to vary linearly with the inverse of the square of the cavity length. Moreover, modes with a lower density of photonic states (DOS) in the cavity may have a lower lasing threshold. This can be accounted for by the dependence of the density of photonic states on the position of the amplifying turn and, accordingly, by the nonuniform electromagnetic field intensity distribution along the cavity for different modes. In the asymmetric structures, the same field energy distribution is responsible for a correlation between k{sub th} and DOS curves. (lasers)

  1. Effect of single and contiguous teeth extractions on alveolar bone remodeling: a study in dogs.

    Science.gov (United States)

    Al-Askar, Mansour; O'Neill, Rory; Stark, Paul C; Griffin, Terrence; Javed, Fawad; Al-Hezaimi, Khalid

    2013-08-01

    Tooth extraction is associated with dimensional changes in the alveolar ridge. The aim was to examine the effect of single versus contiguous teeth extractions on the alveolar ridge remodeling. Five female beagle dogs were randomly divided into three groups on the basis of location (anterior or posterior) and number of teeth extracted - exctraction socket classification: group 1 (one dog): single-tooth extraction; group 2 (two dogs): extraction of two teeth; and group 3 (two dogs): extraction of three teeth in four anterior sites and four posterior sites in both jaws. The dogs were sacrificed after 4 months. Sagittal sectioning of each extraction site was performed and evaluated using microcomputed tomography. Buccolingual or palatal bone loss was observed 4 months after extraction in all three groups. The mean of the alveolar ridge width loss in group 1 (single-tooth extraction) was significantly less than those in groups 2 and 3 (p < .001) (multiple teeth extraction). Three-teeth extraction (group 3) had significantly more alveolar bone loss than two-teeth extraction (group 2) (p < .001). The three-teeth extraction group in the upper and lower showed more obvious resorption on the palatal/lingual side especially in the lower group posterior locations. Contiguous teeth extraction caused significantly more alveolar ridge bone loss as compared with when a single tooth is extracted. © 2011 Wiley Periodicals, Inc.

  2. Limited effect of dopaminergic medication on straight walking and turning in early to moderate Parkinson’s disease during single and dual tasking

    Directory of Open Access Journals (Sweden)

    Morad eElshehabi

    2016-01-01

    Full Text Available Background: In Parkinson’s disease (PD, the effects of dopaminergic medication on straight walking and turning were mainly investigated under single tasking (ST conditions. However, multitasking situations are considered more daily relevant.Methods: Thirty-nine early to moderate PD patients performed the following standarized ST and dual tasks (DT as fast as possible for one minute during On- and Off-medication while wearing inertial sensors: straight walking and turning, checking boxes, and subtracting serial 7s. Quantitative gait parameters, as well as velocity of the secondary tasks were analyzed.Results: The following parameters improved significantly in On-medication during ST: gait velocity during straight walking (p=0.03; step duration (p=0.048 and peak velocity (p=0.04 during turning; velocity of checking boxes during ST (p=0.04 and DT (p=0.04. Velocity of checking boxes was the only parameter that also improved during DT.Conclusion: These results suggest that dopaminergic medication does not relevantly influence straight walking and turning in early to moderate PD during DT.

  3. Leadless pacemaker extraction from a single-center perspective.

    Science.gov (United States)

    González Villegas, Elkin; Al Razzo, Omar; Silvestre García, Jorge; Mesa García, José

    2018-02-01

    Leadless pacemaker can be considered as a technical revolution in cardiac pacing devices, with clear advantages over conventional pacemakers in overcoming all lead-related complications. However, the management of these devices once they reach the end of life (EOL) of the battery is still controversial. In the next years, there will be an increase in the need to define a clear strategy in the management of leadless PM once they reach their EOL. Safe extraction of these devices will define in a great manner this strategy METHODS: We performed the extraction of three functioning Nanostim leadless pacemaker prophylactically in two females and one male patients as part of the Nanostim battery depletion field action recommendation. All patients had a prior transesophageal 3D echocardiography to determine the device intracardiac mobility and the extent of possible endothelialization. For the extractions, we used the Nanostim Retrieval Catheter S1RSIN (St. Jude Medical, St. Paul, MN, USA), which is a proprietary catheter provided by the manufacturing company based on a lasso. Complete extraction of the devices was achieved in all patients using a relatively short fluoroscopic time (16, 19, and 12 minutes). The extraction of leadless pacemakers can be considered as a safe and feasible procedure using the tools provided by the manufacturer and designed for the extraction. However, a very low threshold must be maintained to avoid any risk to the patients. Our extraction time ranges are between 983 and 1,070 days, nevertheless it is necessary to gather more long-term data to assess the feasibility and safety of these procedures. © 2017 Wiley Periodicals, Inc.

  4. Turned on/turned off

    DEFF Research Database (Denmark)

    Petersen, Eva Bendix

    2016-01-01

    position, it attempts to sense into the lived experience of being subject to, and of, turns in social theory. As a whole the paper seeks to work with and allow for multiplicity in tone, focus, researcher positioning, reader positioning, and more, to see what knowledge that does not seek confident closure...

  5. Extracting random numbers from quantum tunnelling through a single diode.

    Science.gov (United States)

    Bernardo-Gavito, Ramón; Bagci, Ibrahim Ethem; Roberts, Jonathan; Sexton, James; Astbury, Benjamin; Shokeir, Hamzah; McGrath, Thomas; Noori, Yasir J; Woodhead, Christopher S; Missous, Mohamed; Roedig, Utz; Young, Robert J

    2017-12-19

    Random number generation is crucial in many aspects of everyday life, as online security and privacy depend ultimately on the quality of random numbers. Many current implementations are based on pseudo-random number generators, but information security requires true random numbers for sensitive applications like key generation in banking, defence or even social media. True random number generators are systems whose outputs cannot be determined, even if their internal structure and response history are known. Sources of quantum noise are thus ideal for this application due to their intrinsic uncertainty. In this work, we propose using resonant tunnelling diodes as practical true random number generators based on a quantum mechanical effect. The output of the proposed devices can be directly used as a random stream of bits or can be further distilled using randomness extraction algorithms, depending on the application.

  6. Tight Turns

    Directory of Open Access Journals (Sweden)

    Jenifer Sutherland

    2013-01-01

    Full Text Available The plain text was task-oriented in a roundabout way, providing detailed instructions for how NOT to build an elaborate sequence of bridges, each one bound to produce, according to chapters one through twenty-three, disastrous results. Graphic novels disguised as illuminated letters twisted the tent-dwelling decipherer into painful self-recognition. The flashlight followed the phases of the moon. Meanwhile one strand of marginalia, written in anxious back-slant, pleaded for some kind of adjustable form for managing the confluence, especially during flood season. I like what we came up with. 'We' is a little big word. In fact the tent turns out to be one of those Borgesian core-tech structures allowing for astonishing internal expansion. There's not much we didn't get in there and not much in there that didn't get us. So I suppose that's it. This tent. This confluence. These children who found me here, turned text into life and made life home.

  7. The nematocyst extract of Hydra attenuata causes single channel events in lipid bilayers.

    Science.gov (United States)

    Weber, J; Schürholz, T; Neumann, E

    1990-01-01

    The nematocyst extract of Hydra attenuata causes single conductance events in reconstituted planar lipid membranes as well as in inside-out patches derived from liposomes. The smallest single channel conductance level of the toxins is 110 pS. The conductance levels increase stepwise with time up to 2000 pS. These large conductance jumps indicate channel cooperativity. If the membrane-voltage is changed from positive to negative values, the single channel events become undefined and noisy, indicating major reorganizations of the proteins which form the channels. The molecular properties of the ionophoric component(s) of the nematocyst extract may help explain the observed macroscopic effects, such as hemolysis of human erythrocytes, after addition of the nematocyst extract.

  8. Single-stage micro-scale solvent extraction in parallel microbore tubes using MDIMJ

    International Nuclear Information System (INIS)

    Darekar, Mayur; Singh, K.K.; Joshi, J.M.; Mukhopadhyay, S.; Shenoy, K.T.

    2016-01-01

    Single-stage micro-scale solvent extraction of U(VI) from simulated lean streams is explored using micro-scale contactor comprising of a MDIMJ (Monoblock Distributor with Integrated Microfluidic Junction) and PTFE microbore tubes. 30% (v/v) TBP in dodecane has been used as the extracting phase. The objective of the study is to demonstrate numbering up approach for scale-up of micro-scale extraction using indigenously conceptualized and fabricated MDIMJ. First the performance of MIDIMJ for equal flow distribution is tested. Then the effects of inlet flow rate and O/A ratio on stage efficiency and percentage extraction are studied. The experiments show that it is easy to scale-up single-stage micro-scale solvent extraction by using MDIMJ for numbering up approach. Maximum capacity tested is 4.8 LPH. With O/A = 2/1, more than 90% extraction is achieved in a very short contact time of less than 3s. The study thus demonstrates possibility of process intensification and easy scale-up of micro-scale solvent extraction

  9. A single-step method for rapid extraction of total lipids from green microalgae.

    Directory of Open Access Journals (Sweden)

    Martin Axelsson

    Full Text Available Microalgae produce a wide range of lipid compounds of potential commercial interest. Total lipid extraction performed by conventional extraction methods, relying on the chloroform-methanol solvent system are too laborious and time consuming for screening large numbers of samples. In this study, three previous extraction methods devised by Folch et al. (1957, Bligh and Dyer (1959 and Selstam and Öquist (1985 were compared and a faster single-step procedure was developed for extraction of total lipids from green microalgae. In the single-step procedure, 8 ml of a 2∶1 chloroform-methanol (v/v mixture was added to fresh or frozen microalgal paste or pulverized dry algal biomass contained in a glass centrifuge tube. The biomass was manually suspended by vigorously shaking the tube for a few seconds and 2 ml of a 0.73% NaCl water solution was added. Phase separation was facilitated by 2 min of centrifugation at 350 g and the lower phase was recovered for analysis. An uncharacterized microalgal polyculture and the green microalgae Scenedesmus dimorphus, Selenastrum minutum, and Chlorella protothecoides were subjected to the different extraction methods and various techniques of biomass homogenization. The less labour intensive single-step procedure presented here allowed simultaneous recovery of total lipid extracts from multiple samples of green microalgae with quantitative yields and fatty acid profiles comparable to those of the previous methods. While the single-step procedure is highly correlated in lipid extractability (r² = 0.985 to the previous method of Folch et al. (1957, it allowed at least five times higher sample throughput.

  10. SNPPhenA: a corpus for extracting ranked associations of single-nucleotide polymorphisms and phenotypes from literature.

    Science.gov (United States)

    Bokharaeian, Behrouz; Diaz, Alberto; Taghizadeh, Nasrin; Chitsaz, Hamidreza; Chavoshinejad, Ramyar

    2017-04-07

    Single Nucleotide Polymorphisms (SNPs) are among the most important types of genetic variations influencing common diseases and phenotypes. Recently, some corpora and methods have been developed with the purpose of extracting mutations and diseases from texts. However, there is no available corpus, for extracting associations from texts, that is annotated with linguistic-based negation, modality markers, neutral candidates, and confidence level of associations. In this research, different steps were presented so as to produce the SNPPhenA corpus. They include automatic Named Entity Recognition (NER) followed by the manual annotation of SNP and phenotype names, annotation of the SNP-phenotype associations and their level of confidence, as well as modality markers. Moreover, the produced corpus was annotated with negation scopes and cues as well as neutral candidates that play crucial role as far as negation and the modality phenomenon in relation to extraction tasks. The agreement between annotators was measured by Cohen's Kappa coefficient where the resulting scores indicated the reliability of the corpus. The Kappa score was 0.79 for annotating the associations and 0.80 for the confidence degree of associations. Further presented were the basic statistics of the annotated features of the corpus in addition to the results of our first experiments related to the extraction of ranked SNP-Phenotype associations. The prepared guideline documents render the corpus more convenient and facile to use. The corpus, guidelines and inter-annotator agreement analysis are available on the website of the corpus: http://nil.fdi.ucm.es/?q=node/639 . Specifying the confidence degree of SNP-phenotype associations from articles helps identify the strength of associations that could in turn assist genomics scientists in determining phenotypic plasticity and the importance of environmental factors. What is more, our first experiments with the corpus show that linguistic-based confidence

  11. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

    Science.gov (United States)

    Chomczynski, P; Sacchi, N

    1987-04-01

    A new method of total RNA isolation by a single extraction with an acid guanidinium thiocyanate-phenol-chloroform mixture is described. The method provides a pure preparation of undegraded RNA in high yield and can be completed within 4 h. It is particularly useful for processing large numbers of samples and for isolation of RNA from minute quantities of cells or tissue samples.

  12. A MISO-ARX-Based Method for Single-Trial Evoked Potential Extraction

    Directory of Open Access Journals (Sweden)

    Nannan Yu

    2017-01-01

    Full Text Available In this paper, we propose a novel method for solving the single-trial evoked potential (EP estimation problem. In this method, the single-trial EP is considered as a complex containing many components, which may originate from different functional brain sites; these components can be distinguished according to their respective latencies and amplitudes and are extracted simultaneously by multiple-input single-output autoregressive modeling with exogenous input (MISO-ARX. The extraction process is performed in three stages: first, we use a reference EP as a template and decompose it into a set of components, which serve as subtemplates for the remaining steps. Then, a dictionary is constructed with these subtemplates, and EPs are preliminarily extracted by sparse coding in order to roughly estimate the latency of each component. Finally, the single-trial measurement is parametrically modeled by MISO-ARX while characterizing spontaneous electroencephalographic activity as an autoregression model driven by white noise and with each component of the EP modeled by autoregressive-moving-average filtering of the subtemplates. Once optimized, all components of the EP can be extracted. Compared with ARX, our method has greater tracking capabilities of specific components of the EP complex as each component is modeled individually in MISO-ARX. We provide exhaustive experimental results to show the effectiveness and feasibility of our method.

  13. Distributions and concentrations of thallium in Korean soils determined by single and sequential extraction procedures.

    Science.gov (United States)

    Lee, Jin-Ho; Kim, Dong-Jin; Ahn, Byung-Koo

    2015-06-01

    The objectives of this study were to investigate the distribution of thallium in soils collected near suspected areas such as cement plants, active and closed mines, and smelters and to examine the extraction of thallium in the soils using 19 single chemical and sequential chemical extraction procedures. Thallium concentrations in soils near cement plants were distributed between 1.20 and 12.91 mg kg(-1). However, soils near mines and smelters contained relatively low thallium concentrations ranging from 0.18 to 1.09 mg kg(-1). Thallium extractability with 19 single chemical extractants from selected soils near cement plants ranged from 0.10% to 8.20% of the total thallium concentration. In particular, 1.0 M NH4Cl, 1.0 M (NH4)2SO4, and 1.0 M CH3COONH4 extracted more thallium than other extractants. Sequential fractionation results of thallium from different soils such as industrially and artificially contaminated soils varied with the soil properties, especially soil pH and the duration of thallium contamination.

  14. Diamond turning of glass

    Energy Technology Data Exchange (ETDEWEB)

    Blackley, W.S.; Scattergood, R.O.

    1988-12-01

    A new research initiative will be undertaken to investigate the critical cutting depth concepts for single point diamond turning of brittle, amorphous materials. Inorganic glasses and a brittle, thermoset polymer (organic glass) are the principal candidate materials. Interrupted cutting tests similar to those done in earlier research are Ge and Si crystals will be made to obtain critical depth values as a function of machining parameters. The results will provide systematic data with which to assess machining performance on glasses and amorphous materials

  15. Single-trial event-related potential extraction through one-unit ICA-with-reference

    Science.gov (United States)

    Lih Lee, Wee; Tan, Tele; Falkmer, Torbjörn; Leung, Yee Hong

    2016-12-01

    Objective. In recent years, ICA has been one of the more popular methods for extracting event-related potential (ERP) at the single-trial level. It is a blind source separation technique that allows the extraction of an ERP without making strong assumptions on the temporal and spatial characteristics of an ERP. However, the problem with traditional ICA is that the extraction is not direct and is time-consuming due to the need for source selection processing. In this paper, the application of an one-unit ICA-with-Reference (ICA-R), a constrained ICA method, is proposed. Approach. In cases where the time-region of the desired ERP is known a priori, this time information is utilized to generate a reference signal, which is then used for guiding the one-unit ICA-R to extract the source signal of the desired ERP directly. Main results. Our results showed that, as compared to traditional ICA, ICA-R is a more effective method for analysing ERP because it avoids manual source selection and it requires less computation thus resulting in faster ERP extraction. Significance. In addition to that, since the method is automated, it reduces the risks of any subjective bias in the ERP analysis. It is also a potential tool for extracting the ERP in online application.

  16. Extraction of the beta-factor for single quantum dots coupled to a photonic crystal waveguide

    DEFF Research Database (Denmark)

    Nielsen, Henri Thyrrestrup; Sapienza, Luca; Lodahl, Peter

    2010-01-01

    We present measurements of the β-factor, describing the coupling efficiency of light emitted by single InAs/GaAs semiconductor quantum dots into a photonic crystal waveguide mode. The β-factor is evaluated by means of time resolved frequency-dependent photoluminescence spectroscopy. The emission...... wavelength of single quantum dots is temperature tuned across the band edge of a photonic crystal waveguide and the spontaneous emission rate is recorded. Decay rates up to 5.7 ns−1, corresponding to a Purcell factor of 5.2, are measured and β-factors up to 85% are extracted. These results prove...

  17. Oversampling method to extract excitatory and inhibitory conductances from single-trial membrane potential recordings.

    Science.gov (United States)

    Bédard, Claude; Béhuret, Sebastien; Deleuze, Charlotte; Bal, Thierry; Destexhe, Alain

    2012-09-15

    Variations of excitatory and inhibitory conductances determine the membrane potential (V(m)) activity of neurons, as well as their spike responses, and are thus of primary importance. Methods to estimate these conductances require clamping the cell at several different levels of V(m), thus making it impossible to estimate conductances from "single trial" V(m) recordings. We present here a new method that allows extracting estimates of the full time course of excitatory and inhibitory conductances from single-trial V(m) recordings. This method is based on oversampling of the V(m). We test the method numerically using models of increasing complexity. Finally, the method is evaluated using controlled conductance injection in cortical neurons in vitro using the dynamic-clamp technique. This conductance extraction method should be very useful for future in vivo applications. Copyright © 2011 Elsevier B.V. All rights reserved.

  18. Evaluation of solvent systems for optimized extractables studies of single use bioprocessing solutions.

    Science.gov (United States)

    Dorival-García, Noemí; Bones, Jonathan

    2017-09-01

    Despite their advantages, there is concern that single-use systems used in biopharmaceutical manufacture might release potentially toxic substances during standard unit operations that negatively impact cell growth. Characterization of the extractables profile for single-use systems is necessary to know which compounds potentially become leachables under operational cell culture conditions. A key issue in the design of extractables studies is the composition of the model solvent, in particular its pH and polarity. In this study, a new approach, based on design of experiments (DoE), has been applied to determine the composition of the model solvent for extractable profiling of single-use bags (SUBs). Particular focus was placed on the determination of the degradation products of the antioxidant Irgafos 168 ® , due to evidence that some of these degradation products have cytotoxic effects on CHO cells. Results indicated that 2-propanol:water is the most appropriate solvent for the extraction of highly hydrophobic compounds with polar groups and/or acid-base properties from SUBs. The described DoE approach simplifies the number of experiments, evaluates all possible solvent water mixtures to select the best extraction solvent based on polarity, establishes the influence of each variable and provides information about variable interaction, which represents an important improvement over current best practice. The developed approach was applied to seven SUBs from different vendors and production dates facilitating the identification of potentially non-satisfactory films for cultivation of CHO cell lines under process conditions. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. Persistent Scatterer Aided Facade Lattice Extraction in Single Airborne Optical Oblique Images

    Science.gov (United States)

    Schack, L.; Soergel, U.; Heipke, C.

    2015-03-01

    We present a new method to extract patterns of regular facade structures from single optical oblique images. To overcome the missing three-dimensional information we incorporate structural information derived from Persistent Scatter (PS) point cloud data into our method. Single oblique images and PS point clouds have never been combined before and offer promising insights into the compatibility of remotely sensed data of different kinds. Even though the appearance of facades is significantly different, many characteristics of the prominent patterns can be seen in both types of data and can be transferred across the sensor domains. To justify the extraction based on regular facade patterns we show that regular facades appear rather often in typical airborne oblique imagery of urban scenes. The extraction of regular patterns is based on well established tools like cross correlation and is extended by incorporating a module for estimating a window lattice model using a genetic algorithm. Among others the results of our approach can be used to derive a deeper understanding of the emergence of Persistent Scatterers and their fusion with optical imagery. To demonstrate the applicability of the approach we present a concept for data fusion aiming at facade lattices extraction in PS and optical data.

  20. Truly work-like work extraction via a single-shot analysis.

    Science.gov (United States)

    Aberg, Johan

    2013-01-01

    The work content of non-equilibrium systems in relation to a heat bath is often analysed in terms of expectation values of an underlying random work variable. However, when optimizing the expectation value of the extracted work, the resulting extraction process is subject to intrinsic fluctuations, uniquely determined by the Hamiltonian and the initial distribution of the system. These fluctuations can be of the same order as the expected work content per se, in which case the extracted energy is unpredictable, thus intuitively more heat-like than work-like. This raises the question of the 'truly' work-like energy that can be extracted. Here we consider an alternative that corresponds to an essentially fluctuation-free extraction. We show that this quantity can be expressed in terms of a one-shot relative entropy measure introduced in information theory. This suggests that the relations between information theory and statistical mechanics, as illustrated by concepts like Maxwell's demon, Szilard engines and Landauer's principle, extends to the single-shot regime.

  1. Headspace single drop microextraction versus dispersive liquid-liquid microextraction using magnetic ionic liquid extraction solvents.

    Science.gov (United States)

    An, Jiwoo; Rahn, Kira L; Anderson, Jared L

    2017-05-15

    A headspace single drop microextraction (HS-SDME) method and a dispersive liquid-liquid microextraction (DLLME) method were developed using two tetrachloromanganate ([MnCl 4 2- ])-based magnetic ionic liquids (MIL) as extraction solvents for the determination of twelve aromatic compounds, including four polyaromatic hydrocarbons, by reversed phase high-performance liquid chromatography (HPLC). The analytical performance of the developed HS-SDME method was compared to the DLLME approach employing the same MILs. In the HS-SDME approach, the magnetic field generated by the magnet was exploited to suspend the MIL solvent from the tip of a rod magnet. The utilization of MILs in HS-SDME resulted in a highly stable microdroplet under elevated temperatures and long extraction times, overcoming a common challenge encountered in traditional SDME approaches of droplet instability. The low UV absorbance of the [MnCl 4 2- ]-based MILs permitted direct analysis of the analyte enriched extraction solvent by HPLC. In HS-SDME, the effects of ionic strength of the sample solution, temperature of the extraction system, extraction time, stir rate, and headspace volume on extraction efficiencies were examined. Coefficients of determination (R 2 ) ranged from 0.994 to 0.999 and limits of detection (LODs) varied from 0.04 to 1.0μgL -1 with relative recoveries from lake water ranging from 70.2% to 109.6%. For the DLLME method, parameters including disperser solvent type and volume, ionic strength of the sample solution, mass of extraction solvent, and extraction time were studied and optimized. Coefficients of determination for the DLLME method varied from 0.997 to 0.999 with LODs ranging from 0.05 to 1.0μgL -1 . Relative recoveries from lake water samples ranged from 68.7% to 104.5%. Overall, the DLLME approach permitted faster extraction times and higher enrichment factors for analytes with low vapor pressure whereas the HS-SDME approach exhibited better extraction efficiencies for

  2. Extracting physics of life at the molecular level: A review of single-molecule data analyses.

    Science.gov (United States)

    Colomb, Warren; Sarkar, Susanta K

    2015-06-01

    Studying individual biomolecules at the single-molecule level has proved very insightful recently. Single-molecule experiments allow us to probe both the equilibrium and nonequilibrium properties as well as make quantitative connections with ensemble experiments and equilibrium thermodynamics. However, it is important to be careful about the analysis of single-molecule data because of the noise present and the lack of theoretical framework for processes far away from equilibrium. Biomolecular motion, whether it is free in solution, on a substrate, or under force, involves thermal fluctuations in varying degrees, which makes the motion noisy. In addition, the noise from the experimental setup makes it even more complex. The details of biologically relevant interactions, conformational dynamics, and activities are hidden in the noisy single-molecule data. As such, extracting biological insights from noisy data is still an active area of research. In this review, we will focus on analyzing both fluorescence-based and force-based single-molecule experiments and gaining biological insights at the single-molecule level. Inherently nonequilibrium nature of biological processes will be highlighted. Simulated trajectories of biomolecular diffusion will be used to compare and validate various analysis techniques. Copyright © 2015 Elsevier B.V. All rights reserved.

  3. Optically stimulated luminescence techniques in retrospective dosimetry using single grains of quartz extracted from unheated materials

    International Nuclear Information System (INIS)

    Joerkov Thomsen, Kristina

    2004-02-01

    This work investigates the possibility of applying optically stimulated luminescence (OSL) in retrospective dose determinations using unheated materials. It focuses on identifying materials suitable for use in assessment of doses absorbed as a consequence of radiation accidents (i.e. accident dosimetry). Special attention has been paid to quartz extracted from unheated building materials such as concrete and mortar. The single-aliquot regeneration-dose (SAR) protocol has been used to determine absorbed doses in small aliquots as well as single grains of quartz. It is shown that OSL measurements of single grains of quartz extracted from poorly-bleached building materials can provide useful information on radiation accident doses, even when the luminescence sensitivity is low. Sources of variance in well-bleached single grain dose distributions have been investigated in detail and it is concluded that the observed variability in the data is consistent with the sum (in quadrature) of a component, which depends on the number of photons detected from each grain, and a fixed component independent of light level. Dose depth profiles through laboratory irradiated concrete bricks have successfully been measured and minimum detection limits of less than 100 mGy are derived. Measurements of thermal transfer in single grains of poorly-bleached quartz show that thermal transfer is variable on a grain-to-grain basis and that it can be a source of variance in single-grain dose distributions. Furthermore, the potential of using common household and workplace chemicals, such as table salt, washing powder and water softener, in retrospective dosimetry has been investigated. It is concluded that such materials should be considered as retrospective dosimeters in the event of a radiation accident. (au)

  4. Land subsidence caused by a single water extraction well and rapid water infiltration

    Directory of Open Access Journals (Sweden)

    I. Martinez-Noguez

    2015-11-01

    Full Text Available Nowadays several parts of the world suffer from land subsidence. This setting of the earth surface occurs due to different factors such as earth quakes, mining activities, and gas, oil and water withdrawal. This research presents a numerical study of the influence of land subsidence caused by a single water extraction well and rapid water infiltration into structural soil discontinuities. The numerical simulation of the infiltration was based on a two-phase flow-model for porous media, and for the deformation a Mohr–Coulomb model was used. A two-layered system with a fault zone is presented. First a single water extraction well is simulated producing a cone-shaped (conical water level depletion, which can cause land subsidence. Land Subsidence can be further increased if a hydrological barrier as a result of a discontinuity, exists. After water extraction a water column is applied on the top boundary for one hours in order to represent a strong storm which produces rapid water infiltration through the discontinuity as well as soil deformation. Both events are analysed and compared in order to characterize deformation of both elements and to get a better understanding of the land subsidence and new fracture formations.

  5. Comparison of sequential and single extraction in order to estimate environmental impact of metals from fly ash

    Directory of Open Access Journals (Sweden)

    Tasić Aleksandra M.

    2016-01-01

    Full Text Available The aim of this paper was to simulate leaching of metals from fly ash in different environmental conditions using ultrasound and microwave-assisted extraction techniques. Single-agent extraction and sequential extraction procedures were used to determine the levels of different metals leaching. The concentration of metals (Al, Fe, Mn, Cd, Co, Cr, Ni, Pb, Cu, As, Be in fly ash extracts were measured by Inductively Coupled Plasma-Atomic Emission Spectrometry. Single-agent extractions of metals were conducted during sonication times of 10, 20, 30, 40 and 50 min. Single-agent extraction with deionized water was also undertaken by exposing samples to microwave radiation at the temperature of 50°C. The sequential extraction was undertaken according to the BCR procedure which was modified and applied to study the partitioning of metals in coal fly ash. The microwave-assisted sequential extraction was performed at different extraction temperatures: 50, 100 and 150°C. The partitioning of metals between the individual fractions was investigated and discussed. The efficiency of the extraction process for each step was examined. In addition, the results of the microwave-assisted sequential extraction are compared to the results obtained by standard ASTM method. The mobility of most elements contained in fly ash is markedly pH sensitive. [Projekat Ministarstva nauke Republike Srbije, br. 172030, br. 176006 i br. III43009

  6. Extracting 3D layout from a single image using global image structures.

    Science.gov (United States)

    Lou, Zhongyu; Gevers, Theo; Hu, Ninghang

    2015-10-01

    Extracting the pixel-level 3D layout from a single image is important for different applications, such as object localization, image, and video categorization. Traditionally, the 3D layout is derived by solving a pixel-level classification problem. However, the image-level 3D structure can be very beneficial for extracting pixel-level 3D layout since it implies the way how pixels in the image are organized. In this paper, we propose an approach that first predicts the global image structure, and then we use the global structure for fine-grained pixel-level 3D layout extraction. In particular, image features are extracted based on multiple layout templates. We then learn a discriminative model for classifying the global layout at the image-level. Using latent variables, we implicitly model the sublevel semantics of the image, which enrich the expressiveness of our model. After the image-level structure is obtained, it is used as the prior knowledge to infer pixel-wise 3D layout. Experiments show that the results of our model outperform the state-of-the-art methods by 11.7% for 3D structure classification. Moreover, we show that employing the 3D structure prior information yields accurate 3D scene layout segmentation.

  7. Extraction and characterization of cellulose single fibers from native african napier grass.

    Science.gov (United States)

    Reddy, K Obi; Maheswari, C Uma; Dhlamini, M S; Mothudi, B M; Kommula, V P; Zhang, Jinming; Zhang, Jun; Rajulu, A Varada

    2018-05-15

    With increasing awareness of protecting the environment, the demand for renewable and environmental materials is increasing. In this work, the cellulose single fibers (CSFs) were extracted from the African native Napier grass fibers (NGFs) by chemical process. NGFs and CSFs were characterized for their chemical composition, structure, morphology, crystallinity and thermal properties using, chemical analysis, FTIR, 13C CP/MAS NMR, SEM, XRD and TGA techniques. The resulted CSFs had higher α-cellulose content, crystallinity and thermal stability than the pristine NGFs. SEM images showed cleaner and rough surfaces for the CSFs when compared to those of NGFs. About 69% of the extracted CSFs showed a diameter range between 4 and 10 μm. FTIR and 13C CP/MAS NMR spectra confirmed the removal of lignin and hemicellulose components after chemical treatments. Copyright © 2018 Elsevier Ltd. All rights reserved.

  8. Effect of surfactant on single drop mass transfer for extraction of aromatics from lubricating oils

    Science.gov (United States)

    Izza, H.; Ben Abdessalam, S.; Korichi, M.

    2018-03-01

    Solvent extraction is an effective method for the reduction of the content of aromatic of lubricating oil. Frequently, with phenol, furfural, the NMP (out of N-methyl pyrrolidone). The power solvent and the selectivity can be still to increase while using surfactant as additive which facilitates the separation of phase and increases the yeild in raffinat. Liquid-liquid mass transfer coefficients for single freely rising drops in the presence of surfactant in an extraction column have been investigated. The surfactant used in this study was sodium lauryl ether sulfate (SLES). The experiments were performed by bubbling a solvent as a series of individual drops from the top of the column containing furfural-SLES solution. The column used in this experiment was made from glass with 17 mm inner diameter and a capacity of 125ml. The effects of the concentration of surfactant on the overall coefficient of mass transfer was investigated.

  9. Purification of Single-Wall carbon nanotubes by heat treatment and supercritical extraction

    Directory of Open Access Journals (Sweden)

    Mariana Bertoncini

    2011-09-01

    Full Text Available Arc discharge is the most practical method for the synthesis of single wall carbon nanotubes (SWCNT. However, the production of SWCNT by this technique has low selectivity and yield, requiring further purification steps. This work is a study of purification of SWCNT by heat treatment in an inert atmosphere followed by supercritical fluid extraction. The raw arc discharge material was first heat-treated at 1250 °C under argon. The nanotubes were further submitted to an extraction process using supercritical CO2 as solvent. A surfactant (tributylphosphate, TBP and a chelating agent (hexafluoroacetylacetone, HFA were used together to eliminate metallic impurities from the remaining arc discharge catalysts. Analysis of Inductively Coupled Plasma-Atomic Emission Spectrometry (ICP-AES showed an efficient removal of iron and cobalt (>80%. The purified nanotubes were further analyzed by TGA and Raman spectroscopy.

  10. Classifying running speed conditions using a single wearable sensor: Optimal segmentation and feature extraction methods.

    Science.gov (United States)

    Benson, Lauren C; Clermont, Christian A; Osis, Sean T; Kobsar, Dylan; Ferber, Reed

    2018-04-11

    Accelerometers have been used to classify running patterns, but classification accuracy and computational load depends on signal segmentation and feature extraction. Stride-based segmentation relies on identifying gait events, a step avoided by using window-based segmentation. For each segment, discrete points can be extracted from the accelerometer signal, or advanced features can be computed. Therefore, the purpose of this study was to examine how different segmentation and feature extraction methods influence the accuracy and computational load of classifying running conditions. Forty-four runners ran at their preferred speed and 25% faster than preferred while an accelerometer at the lower back recorded 3D accelerations. Computational load was determined as the accelerometer signal was segmented into single and five strides, and corresponding small and large windows, with discrete points extracted from the single stride segments and advanced features computed from all four segment types. Each feature set was used to classify speed conditions and classification accuracy was recorded. Computational load and classification accuracy were compared across all feature sets using a repeated-measures MANOVA, with follow-up t-tests to compare feature type (discrete vs. advanced), segmentation method (stride- vs. window-based), and segment size (small vs. large), using a Bonferroni-adjusted α = 0.003. The five-stride (97.49 (±4.57)%) and large-window advanced (97.23 (±5.51)%) feature sets produced the greatest classification accuracy, but the large-window advanced feature set had a lower computational load (0.0041 (±0.0002)s) than the stride-based feature sets. Therefore, using a few advanced features and large overlapping window sizes yields the best performance of both classification accuracy and computational load. Copyright © 2018 Elsevier Ltd. All rights reserved.

  11. Immediate loading of post-extractive single-tooth implants: a 1-year prospective study.

    Science.gov (United States)

    Cristalli, Maria Paola; Marini, Roberta; La Monaca, Gerardo; Sepe, Claudio; Tonoli, Federica; Annibali, Susanna

    2015-09-01

    The aim of this prospective clinical trial was to assess clinical, radiological, and esthetic outcomes of immediate-loaded post-extractive implants after 1 year of follow-up. Twenty-four consecutive patients (15 females and nine males) with a mean age of 47.27 years (range 35-65) requiring single-tooth extraction in the maxillary or mandibular anterior or premolar areas were enrolled. Twenty-five NobelActive implants (Nobel Biocare, Göteborg, Sweden) were placed and loaded immediately after tooth extraction. The definitive prosthetic restoration was delivered 6 months later. Clinical parameters, marginal bone loss, as well as, pink and white esthetic scores (PES and WES) were evaluated at 3, 6, and 12 months after implant placement. After 12-month follow-up period, a success rate of 91.67% was reported: Two of the 25 initially placed implants were lost after 4 weeks due to lack of osseointegration. The mean marginal bone loss after 1-year follow-up was 0.383 (SD ± 0.749) at mesial site and 0.278 (SD ± 0.595) at distal site. No statistically significant changes in the full-mouth plaque score (FMPS) and in the full-mouth bleeding score (FMBS) were observed from baseline to 12 months. The mean total PES/WES was 17.13 ± 1.91 (range: 13-20). None of 23 implants had an overall score immediate placement and loading of a single NobelActive(™) implant in a fresh extraction socket may be considered a valuable and predictable option in terms of implant success as well as hard and soft tissues stability. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  12. Turning the volume down on heavy metals using tuned diatomite. A review of diatomite and modified diatomite for the extraction of heavy metals from water

    Energy Technology Data Exchange (ETDEWEB)

    Danil de Namor, Angela F., E-mail: A.Danil-De-Namor@surrey.ac.uk [Instituto Nacional de Tecnologia Industrial, Parque Tecnologico Industrial Miguelete, Buenos Aires (Argentina); Department of Chemistry, University of Surrey, Guildford, Surrey GU2 7XH (United Kingdom); El Gamouz, Abdelaziz [Department of Chemistry, University of Surrey, Guildford, Surrey GU2 7XH (United Kingdom); Frangie, Sofia; Martinez, Vanina; Valiente, Liliana [Instituto Nacional de Tecnologia Industrial, Parque Tecnologico Industrial Miguelete, Buenos Aires (Argentina); Webb, Oliver A. [Department of Chemistry, University of Surrey, Guildford, Surrey GU2 7XH (United Kingdom)

    2012-11-30

    Highlights: Black-Right-Pointing-Pointer Critical assessment of published work on raw and modified diatomites. Black-Right-Pointing-Pointer Counter-ion effect on the extraction of heavy metal speciation by diatomite. Black-Right-Pointing-Pointer Selection of the counter-ion by the use of existing thermodynamic data. Black-Right-Pointing-Pointer Enrichment of diatomites by attaching heavy metal selective functionalities. Black-Right-Pointing-Pointer Supramolecular chemistry for conferring selectivity to diatomites. - Abstract: Contamination of water by heavy metals is a global problem, to which an inexpensive and simple solution is required. Within this context the unique properties of diatomite and its abundance in many regions of the world have led to the current widespread interest in this material for water purification purposes. Defined sections on articles published on the use of raw and modified diatomite for the removal of heavy metal pollutants from water are critically reviewed. The capability of the materials as extracting agents for individual species and mixtures of heavy metals are considered in terms of the kinetics, the thermodynamics and the recyclability for both, the pollutant and the extracting material. The concept of 'selectivity' for the enrichment of naturally occurring materials such as diatomite through the introduction of suitable functionalities in their structure to target a given pollutant is emphasised. Suggestions for further research in this area are given.

  13. Single blastocyst transfer after ICSI from ejaculate spermatozoa, percutaneous epididymal sperm aspiration (PESA) or testicular sperm extraction (TESE)

    OpenAIRE

    Nilsson, Staffan; Waldenström, Urban; Engström, Ann-Britt; Hellberg, Dan

    2007-01-01

    Purpose: To investigate the outcome of IVF following intracytoplasmic sperm injection (ICSI) from ejaculate, percutaneous epididymal sperm aspiration (PESA) and testicular sperm extraction (TESE), with subsequent blastocyst culture and single blastocyst transfer.

  14. Rational concept to recognize/extract single-walled carbon nanotubes with a specific chirality.

    Science.gov (United States)

    Ozawa, Hiroaki; Fujigaya, Tsuyohiko; Niidome, Yasuro; Hotta, Naosuke; Fujiki, Michiya; Nakashima, Naotoshi

    2011-03-02

    Single-walled carbon nanotubes (SWNTs) have remarkable and unique electronic, mechanical, and thermal properties, which are closely related to their chiralities; thus, the chirality-selective recognition/extraction of the SWNTs is one of the central issues in nanotube science. However, any rational materials design enabling one to efficiently extract/solubilize pure SWNT with a desired chirality has yet not been demonstrated. Herein we report that certain chiral polyfluorene copolymers can well-recognize SWNTs with a certain chirality preferentially, leading to solubilization of specific chiral SWNTs. The chiral copolymers were prepared by the Ni(0)-catalyzed Yamamoto coupling reaction of 2,7-dibromo-9,9-di-n-decylfluorene and 2,7-dibromo-9,9-bis[(S)-(+)-2-methylbutyl]fluorene comonomers. The selectivity of the SWNT chirality was mainly determined by the relative fraction of the achiral and chiral side groups. By a molecular mechanics simulation, the cooperative interaction between the fluorene moiety, alkyl side chain, and graphene wall were responsible for the recognition/dissolution ability of SWNT chirality. This is a first example describing the rational design and synthesis of novel fluorene-based copolymers toward the recognition/extraction of targeted (n, m) chirality of the SWNTs.

  15. A COMPARATIVE ANALYSIS OF SINGLE AND COMBINATION FEATURE EXTRACTION TECHNIQUES FOR DETECTING CERVICAL CANCER LESIONS

    Directory of Open Access Journals (Sweden)

    S. Pradeep Kumar Kenny

    2016-02-01

    Full Text Available Cervical cancer is the third most common form of cancer affecting women especially in third world countries. The predominant reason for such alarming rate of death is primarily due to lack of awareness and proper health care. As they say, prevention is better than cure, a better strategy has to be put in place to screen a large number of women so that an early diagnosis can help in saving their lives. One such strategy is to implement an automated system. For an automated system to function properly a proper set of features have to be extracted so that the cancer cell can be detected efficiently. In this paper we compare the performances of detecting a cancer cell using a single feature versus a combination feature set technique to see which will suit the automated system in terms of higher detection rate. For this each cell is segmented using multiscale morphological watershed segmentation technique and a series of features are extracted. This process is performed on 967 images and the data extracted is subjected to data mining techniques to determine which feature is best for which stage of cancer. The results thus obtained clearly show a higher percentage of success for combination feature set with 100% accurate detection rate.

  16. Investigation of single-cycle separation process based on forward and backward extractions of actinides and fission products

    International Nuclear Information System (INIS)

    Sasaki, Yuji; Tsubata, Yasuhiro; Shirasu, Noriko; Morita, Keisuke; Suzuki, Tomoya

    2015-01-01

    We have been developing a new partitioning method of high-level radioactive waste by the single-cycle extraction process. This process is composed of the extraction of actinides (An) and fission products (FP, e.g., Pd, Ru, Mo and Tc), and mutual separation by reverse extraction. The extractant employed in this process is required to extract soft, hard acid metals and oxonium anions simultaneously. The NTAamide (N,N,N',N',N”,N”,-hexaoctyl-nitrilotriacetamide) is one of the candidate extractants. After the extraction of An and FP, the mutual separation by reverse-extraction should be set up. Distribution ratios of Pd and Ru, which are obtained by NTAamide extraction, can be suppressed by masking agents, thiourea, systeine, diethylenetriamine, and trisaminoethylamine. The masking of Mo can be performed using methylimino-N,N'-diethylacetamide (MIDEA), NTAamide(C2) and iminodimethylphosphoric acid, and Re can be stripped using an aqueous phase with high pH. The information on extraction and masking for these metals will be utilized in the development of the single-cycle process. (author)

  17. Relevant Feature Integration and Extraction for Single-Trial Motor Imagery Classification.

    Science.gov (United States)

    Li, Lili; Xu, Guanghua; Zhang, Feng; Xie, Jun; Li, Min

    2017-01-01

    Brain computer interfaces provide a novel channel for the communication between brain and output devices. The effectiveness of the brain computer interface is based on the classification accuracy of single trial brain signals. The common spatial pattern (CSP) algorithm is believed to be an effective algorithm for the classification of single trial brain signals. As the amplitude feature for spatial projection applied by this algorithm is based on a broad frequency bandpass filter (mainly 5-30 Hz) in which the frequency band is often selected by experience, the CSP is sensitive to noise and the influence of other irrelevant information in the selected broad frequency band. In this paper, to improve the CSP, a novel relevant feature integration and extraction algorithm is proposed. Before projecting, we integrated the motor relevant information to suppress the interference of noise and irrelevant information, as well as to improve the spatial difference for projection. The algorithm was evaluated with public datasets. It showed significantly better classification performance with single trial electroencephalography (EEG) data, increasing by 6.8% compared with the CSP.

  18. Ultrasound-assisted single extraction tests for rapid assessment of metal extractability from soils by total reflection X-ray fluorescence.

    Science.gov (United States)

    De La Calle, I; Cabaleiro, N; Lavilla, I; Bendicho, C

    2013-09-15

    In this work, ultrasound-assisted extraction (UAE) was employed for acceleration of metal extraction from soil samples. After extraction, multielemental analysis (Cr, Mn, Fe, Ni, Cu, Zn and Pb) of EDTA and acetic acid extracts was performed by total reflection X-ray fluorescence spectrometry (TXRF). High-intensity ultrasonic processors, i.e. the ultrasonic probe (50W) and the cup-horn sonoreactor (200W) were applied. Both ultrasonic procedures were compared with a miniaturized version of the single extraction scheme proposed by the Standards, Measurements and Testing program (SM&T). The extraction time with EDTA was reduced from 1h (conventional procedure) to 2 min (ultrasonic probe) or to 10 min (cup-horn sonoreactor). The time required for acetic acid extraction was also reduced from 16 h (conventional procedure) to 6 min (ultrasonic probe) or to 30 min (cup-horn sonoreactor). In addition, the amount of sample and extractants was drastically reduced as a result of the miniaturization implemented in the developed approaches. The combination of UAE and TXRF allows assessing the potential metal mobility and bioavailability in a simple way. Copyright © 2013 Elsevier B.V. All rights reserved.

  19. Single fibre strength of cellulosic fibre extracted from "Belatlan roots" plant

    Science.gov (United States)

    M. Hanis. A., H.; Majid, M. S. Abdul; Ridzuan, M. J. M.; Fahmi, I.

    2017-12-01

    The tensile strength of a fibre extracted from "Belatlan Root" plant was investigated as potential reinforcement material in polymeric composites. Following retting process, the fibres were manually extracted from "Belatlan" root's plant. The fibres were treated with 5 % 10 %, 15 %, and 20 % sodium hydroxide (NaOH) wt. % concentration for 24 h. The single fibre tests were then performed in accordance with ASTM D3822-07 standard. The surfaces of the fibres prior and after the treatment were observed with a metallurgical Microscope MT8100 and the physical properties were recorded. Physically, in the post treatment, the fibre showed a decrease in diameter with increase in NaOH concentration The results from the mechanical testing indicates that samples subjected to 5 % NaOH treatment yielded the highest tensile strength and elastic modulus at 89.05 MPa ± 2.75 and 3.81 GPa ± 0.09 respectively compared to untreated fibres. This represents an increase of almost 72 % in tensile strength and 42 % for elastic modulus. The findings support the preliminary information for incorporating the "Belatlan Root" as possible reinforcing materials in composite structures.

  20. Spherical Projection Based Straight Line Segment Extraction for Single Station Terrestrial Laser Point Cloud

    Directory of Open Access Journals (Sweden)

    ZHANG Fan

    2015-06-01

    Full Text Available Due to the discrete distribution computing errors and lack of adaptability are ubiquitous in the current straight line extraction for TLS data methods. A 3D straight line segment extraction method is proposed based on spherical projection for single station terrestrial laser point clouds. Firstly, horizontal and vertical angles of each laser point are calculated by means of spherical coordinates, intensity panoramic image according to the two angles is generated. Secondly, edges which include straight line features are detected from intensity panoramic image by using of edge detection algorithm. Thirdly, great circles are detected from edges of panoramic image using spherical Hough transform. According to the axiom that a straight line segment in 3D space is a spherical great circle after spherical projection, detecting great circles from spherical projected data sets is essentially detecting straight line segments from 3D data sets without spherical projection. Finally, a robust 3D straight line fitting method is employed to fitting the straight lines and calculating parameters of the straight line segments. Experiments using different data sets and comparison with other methods show the accuracy and applicability of the proposed method.

  1. A retrospective analysis of episodes of single tooth extraction under general anaesthesia for adults.

    Science.gov (United States)

    Hong, B; Birnie, A

    2016-01-15

    To investigate the provision of adult dental extraction under general anaesthesia (DGA) at the Royal Cornwall Hospitals NHS Trust (RCHT)-- specifically adult single tooth DGA episodes in regards to numbers, demographics, justifications, and appropriateness regarding the use of resources. Data were collected retrospectively from the patient case notes and electronic records for the complete study cohort. This study included all episodes of adult single tooth DGA in all RCHT sites during 2014, except for mandibular third molar and impacted teeth. Each case was tested against the DGA case selection criteria empirically devised for this study. In 2014, 106 episodes of adult single tooth DGA were carried out in RCHT that met the inclusion criteria. Younger females from more socio-economically deprived areas of Cornwall were increasingly likely to have this procedure. Mental disorders were the most prevalent co-morbidity (21.7%) in this cohort. The vast majority of patients (93.4%) had previously tolerated dental treatment without the need for general anaesthesia (GA). Many referrals (46.2%) and listings (30.2%) specifically stated patient demand-driven reasons. None of the cohort had DGA due to failure of sedation. There were potentially 11 episodes that met the DGA case selection criteria. Patients waited for 126 days (median) from the referral date for an operation which took seven minutes (median) to complete. The majority (83%) of the cases were simple exodontia. Twenty patients (18.9%) had previous DGA. Potentially a considerable proportion of GA prescription appeared to be driven by patient demand rather than clinical need. This study poses a fundamental question--what drives the demand for DGA? National data collection and specific DGA case selection criteria are recommended.

  2. Study of time-frequency characteristics of single snores: extracting new information for sleep apnea diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Castillo Escario, Y.; Blanco Almazan, D.; Camara Vazquez, M.A.; Jane Campos, R.

    2016-07-01

    Obstructive sleep apnea (OSA) is a highly prevalent chronic disease, especially in elderly and obese population. Despite constituting a huge health and economic problem, most patients remain undiagnosed due to limitations in current strategies. Therefore, it is essential to find cost-effective diagnostic alternatives. One of these novel approaches is the analysis of acoustic snoring signals. Snoring is an early symptom of OSA which carries pathophysiological information of high diagnostic value. For this reason, the main objective of this work is to study the characteristics of single snores of different types, from healthy and OSA subjects. To do that, we analyzed snoring signals from previous databases and developed an experimental protocol to record simulated OSA-related sounds and characterize the response of two commercial tracheal microphones. Automatic programs for filtering, downsampling, event detection and time-frequency analysis were built in MATLAB. We found that time-frequency maps and spectral parameters (central, mean and peak frequency and energy in the 100-500 Hz band) allow distinguishing regular snores of healthy subjects from non-regular snores and snores of OSA subjects. Regarding the two commercial microphones, we found that one of them was a suitable snoring sensor, while the other had a too restricted frequency response. Future work shall include a higher number of episodes and subjects, but our study has contributed to show how important the differences between regular and non-regular snores can be for OSA diagnosis, and how much clinically relevant information can be extracted from time-frequency maps and spectral parameters of single snores. (Author)

  3. Diamond turning of thermoplastic polymers

    Energy Technology Data Exchange (ETDEWEB)

    Smith, E.; Scattergood, R.O.

    1988-12-01

    Single point diamond turning studies were made using a series of thermoplastic polymers with different glass transition temperatures. Variations in surface morphology and surface roughness were observed as a function of cutting speed. Lower glass transition temperatures facilitate smoother surface cuts and better surface finish. This can be attributed to the frictional heating that occurs during machining. Because of the very low glass transition temperatures in polymeric compared to inorganic glasses, the precision machining response can be very speed sensitive.

  4. Variation with depth of dose distributions in single grains of quartz extracted from an irradiated concrete block

    DEFF Research Database (Denmark)

    Thomsen, Kristina Jørkov; Jain, M.; Bøtter-Jensen, L.

    2003-01-01

    irradiated normal to one face in the laboratory using Cs-137 gamma photons. The OSL dose-depth profile for the irradiated block was determined by measuring the dose distributions from single quartz grains extracted from slices taken across the block and compared with that predicted using Monte Carlo...

  5. Solanum tuberosum and Lycopersicon esculentum Leaf Extracts and Single Metabolites Affect Development and Reproduction of Drosophila melanogaster.

    Science.gov (United States)

    Ventrella, Emanuela; Adamski, Zbigniew; Chudzińska, Ewa; Miądowicz-Kobielska, Mariola; Marciniak, Paweł; Büyükgüzel, Ender; Büyükgüzel, Kemal; Erdem, Meltem; Falabella, Patrizia; Scrano, Laura; Bufo, Sabino Aurelio

    2016-01-01

    Glycoalkaloids are secondary metabolites commonly found in Solanaceae plants. They have anti-bacterial, anti-fungal and insecticidal activities. In the present study we examine the effects of potato and tomato leaf extracts and their main components, the glycoalkaloids α-solanine, α-chaconine and α-tomatine, on development and reproduction of Drosophila melanogaster wild-type flies at different stages. Parental generation was exposed to five different concentrations of tested substances. The effects were examined also on the next, non-exposed generation. In the first (exposed) generation, addition of each extract reduced the number of organisms reaching the pupal and imaginal stages. Parent insects exposed to extracts and metabolites individually applied showed faster development. However, the effect was weaker in case of single metabolites than in case of exposure to extracts. An increase of developmental rate was also observed in the next, non-exposed generation. The imagoes of both generations exposed to extracts and pure metabolites showed some anomalies in body size and malformations, such as deformed wings and abdomens, smaller black abdominal zone. Our results further support the current idea that Solanaceae can be an impressive source of molecules, which could efficaciously be used in crop protection, as natural extract or in formulation of single pure metabolites in sustainable agriculture.

  6. Solanum tuberosum and Lycopersicon esculentum Leaf Extracts and Single Metabolites Affect Development and Reproduction of Drosophila melanogaster.

    Directory of Open Access Journals (Sweden)

    Emanuela Ventrella

    Full Text Available Glycoalkaloids are secondary metabolites commonly found in Solanaceae plants. They have anti-bacterial, anti-fungal and insecticidal activities. In the present study we examine the effects of potato and tomato leaf extracts and their main components, the glycoalkaloids α-solanine, α-chaconine and α-tomatine, on development and reproduction of Drosophila melanogaster wild-type flies at different stages. Parental generation was exposed to five different concentrations of tested substances. The effects were examined also on the next, non-exposed generation. In the first (exposed generation, addition of each extract reduced the number of organisms reaching the pupal and imaginal stages. Parent insects exposed to extracts and metabolites individually applied showed faster development. However, the effect was weaker in case of single metabolites than in case of exposure to extracts. An increase of developmental rate was also observed in the next, non-exposed generation. The imagoes of both generations exposed to extracts and pure metabolites showed some anomalies in body size and malformations, such as deformed wings and abdomens, smaller black abdominal zone. Our results further support the current idea that Solanaceae can be an impressive source of molecules, which could efficaciously be used in crop protection, as natural extract or in formulation of single pure metabolites in sustainable agriculture.

  7. Solanum tuberosum and Lycopersicon esculentum Leaf Extracts and Single Metabolites Affect Development and Reproduction of Drosophila melanogaster

    Science.gov (United States)

    Ventrella, Emanuela; Adamski, Zbigniew; Chudzińska, Ewa; Miądowicz-Kobielska, Mariola; Marciniak, Paweł; Büyükgüzel, Ender; Büyükgüzel, Kemal; Erdem, Meltem; Falabella, Patrizia; Scrano, Laura; Bufo, Sabino Aurelio

    2016-01-01

    Glycoalkaloids are secondary metabolites commonly found in Solanaceae plants. They have anti-bacterial, anti-fungal and insecticidal activities. In the present study we examine the effects of potato and tomato leaf extracts and their main components, the glycoalkaloids α-solanine, α-chaconine and α-tomatine, on development and reproduction of Drosophila melanogaster wild-type flies at different stages. Parental generation was exposed to five different concentrations of tested substances. The effects were examined also on the next, non-exposed generation. In the first (exposed) generation, addition of each extract reduced the number of organisms reaching the pupal and imaginal stages. Parent insects exposed to extracts and metabolites individually applied showed faster development. However, the effect was weaker in case of single metabolites than in case of exposure to extracts. An increase of developmental rate was also observed in the next, non-exposed generation. The imagoes of both generations exposed to extracts and pure metabolites showed some anomalies in body size and malformations, such as deformed wings and abdomens, smaller black abdominal zone. Our results further support the current idea that Solanaceae can be an impressive source of molecules, which could efficaciously be used in crop protection, as natural extract or in formulation of single pure metabolites in sustainable agriculture. PMID:27213896

  8. The Local Turn

    NARCIS (Netherlands)

    Warren, Carol; Visser, Leontine

    2016-01-01

    The local turn in good governance theory and practice responded to critiques of the ineffectiveness of state management and the inequity of privatization alternatives in natural resource management. Confounding expectations of greater effectiveness from decentralised governance, including

  9. -and -turns in proteins revisited: A new set of amino acid turn ...

    Indian Academy of Sciences (India)

    -turns (7153) and -turns (911) extracted from these proteins were used to derive a revised set of type-dependent amino acid positional preferences and potentials. Compared with previous results, the preference for proline, methionine and tryptophan has increased and the preference for glutamine, valine, glutamic acid ...

  10. Telemetry as a tool to measure sedative effects of a valerian root extract and its single constituents in mice.

    Science.gov (United States)

    Chow, Nicholas K; Fretz, Michael; Hamburger, Matthias; Butterweck, Veronika

    2011-05-01

    Valeriana officinalis L. is a popular herbal treatment for mild sleep disorders. Clinical and non-clinical studies found contradictory results for valerian extracts and single constituents regarding the influence on sleep parameters. It was the aim of this study to investigate the sedative effects of a valerian root extract. Therefore, locomotor activity and core body temperature were recorded in male mice using radiotelemetry. A 70 % ethanolic extract prepared from the roots of V. officinalis (s. l.) and some of its single constituents, valerenic acid, linarin, and apigenin, were tested for effects on locomotion and body temperature over 180 minutes after oral administration. The extract was tested in a dose range of 250-1000 mg/kg, and only a dose of 1000 mg/kg valerian extract showed a mild short-term sedative effect with reduced locomotor activity between 66-78 min minutes after administration. Paradoxically, an increased activity was observed after 150 minutes after gavage. A dose of 1 mg/kg valerenic acid produced an intermittent stimulation of activity. However, a mild short-term sedative effect was found for linarin at 12 mg/kg and apigenin at 1.5 mg/kg. Considering the cumulative locomotor activity over the observation period of 180 min, it is concluded that neither the extract nor one of the compounds had considerable sedative effects. More precisely, the observed short-term changes in activity pattern indicate that valerian extract as well as the flavonoids linarin and apigenin are rather effective to reduce sleep latency than to act as a sleep-maintaining agent. © Georg Thieme Verlag KG Stuttgart · New York.

  11. Effects of the chemical structure of polyfluorene on selective extraction of semiconducting single-walled carbon nanotubes.

    Science.gov (United States)

    Fukumaru, Takahiro; Toshimitsu, Fumiyuki; Fujigaya, Tsuyohiko; Nakashima, Naotoshi

    2014-06-07

    The selective recognition/extraction of semiconducting (sem)- and metallic (met)-single-walled carbon nanotubes (SWNTs) is still a great challenge in the science and technology of carbon nanotubes because their selective synthesis is still difficult. Poly(9,9-dioctyl-fluorene-2,7-diyl) (2C8-PF) and its derivatives are widely used polymers in carbon nanotube science and technology since they only extract sem-SWNTs from the mixture of sem-/met-SWNTs, while the separation mechanism is still unclear. In this study, we focus on the alkyl chain number on the polyfluorenes (PFs) to understand the mechanism for selective recognition. Here we describe the synthesis of mono-octyl moiety-carrying polyfluorene (poly(9-octyl-9H-fluorene-2,7-diyl), C8H-PF), and characterized its selective SWNT recognition/extraction ability, and found that the C8H-PF solubilized sem-SWNTs with a diameter of 0.9-1.1 nm, whose behavior is similar to that of 2C8-PF. In addition, C8H-PF selectively extracted sem-SWNTs with larger diameters (average diameter = 1.4 nm), whose behavior is different from that of 2C8-PF. Molecular mechanics simulations were carried out to understand such specific solubilization behavior. This study provides an insight into the design and synthesis of PF-based polymers and copolymers that exhibit efficient selective sem-SWNT recognition/extraction ability and their applications.

  12. Single Cell Oil Producing Yeasts Lipomyces starkeyi and Rhodosporidium toruloides: Selection of Extraction Strategies and Biodiesel Property Prediction

    Directory of Open Access Journals (Sweden)

    Nemailla Bonturi

    2015-05-01

    Full Text Available Single cell oils (SCOs are considered potential raw material for the production of biodiesel. Rhodosporidium sp. and Lipomyces sp. are good candidates for SCO production. Lipid extractability differs according to yeast species and literature on the most suitable method for each oleaginous yeast species is scarce. This work aimed to investigate the efficiency of the most cited strategies for extracting lipids from intact and pretreated cells of Rhodosporidium toruloides and Lipomyces starkeyi. Lipid extractions were conducted using hexane or combinations of chloroform and methanol. The Folch method resulted in the highest lipid yields for both yeasts (42% for R. toruloides and 48% for L. starkeyi. Also, this method eliminates the cell pretreatment step. The Bligh and Dyer method underestimated the lipid content in the tested strains (25% for R. toruloides and 34% for L. starkeyi. Lipid extractability increased after acid pretreatment for the Pedersen, hexane, and Bligh and Dyer methods. For R. toruloides unexpected fatty acid methyl esters (FAME composition were found for some lipid extraction strategies tested. Therefore, this work provides useful information for analytical and process development aiming at biodiesel production from the SCO of these two yeast species.

  13. Single-molecule analysis of DNA replication in Xenopus egg extracts

    NARCIS (Netherlands)

    Yardimci, Hasan; Loveland, Anna B.; van Oijen, Antoine M.; Walter, Johannes C.; Mechali, Marcel

    The recent advent in single-molecule imaging and manipulation methods has made a significant impact on the understanding of molecular mechanisms underlying many essential cellular processes. Single-molecule techniques such as electron microscopy and DNA fiber assays have been employed to study the

  14. Turning Sunlight into Electricity

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 11; Issue 7. Turning Sunlight into Electricity - Inorganic Solar Cells and Beyond. A K Shukla. General Article Volume 11 Issue 7 July 2006 pp 42-50. Fulltext. Click here to view fulltext PDF. Permanent link:

  15. Turning lead into gold

    DEFF Research Database (Denmark)

    Jensen, Steffen Moltrup Ernø

    For years the field of entrepreneurship has been blinded by the alchemical promise of turning lead into gold, of finding the ones most likely to become the next Branson, Zuckerberg or Gates. The promise has been created in the midst of political and scientific agendas where certain individuals...

  16. Turning to alcohol?

    International Nuclear Information System (INIS)

    Reiboro, S.K.

    1998-01-01

    Brazil is examining whether turning to alcohol could solve its problems. The fuel alcohol producers are lobbying hard for the government to increase the use of alcohol to fuel the country's cars. Not only does using alcohol reduce CO 2 , runs the argument, but the Kyoto agreement might just attract international financing for the project. (author)

  17. and γγ-turns in proteins revisited: A new set of amino acid turn-type de

    Indian Academy of Sciences (India)

    cent Protein Data Bank has nearly doubled and the number of γ-turns in a representative set of 320 proteins has in- creased over seven times since the previous analysis. β-turns (7153) and γ-turns (911) extracted from these proteins were used to derive a revised set of type-dependent amino acid positional preferences and ...

  18. Confocal Raman microscopy for in situ detection of solid-phase extraction of pyrene into single C18-silica particles.

    Science.gov (United States)

    Kitt, Jay P; Harris, Joel M

    2014-02-04

    Solid-phase extraction (SPE) is a well-known method for separating and preconcentrating analytes prior to ex situ detection and quantification. Despite advances in the miniaturization of solid-phase extraction, the technique has not evolved to meet the needs for detection in small-scale microfluidic devices. Although successful efforts have led to smaller-scale extractors that allow preconcentration from small volumes, detection within correspondingly small volumes has remained out of reach because of analyte dilution during a postextraction transfer or "wash-off" step prior to detection. In this work, successful extraction into subpicoliter collection volumes is accomplished by using a single chromatographic particle as an extractor; wash-off dilution is completely avoided by using confocal Raman microscopy for in situ detection within the single-particle collection phase. Specifically, micromolar concentrations of pyrene in methanol/water solution were equilibrated with an individual C18-functionalized silica particle, and Raman spectra were acquired from a small confocal sampling volume (∼1 fL) within the particle interior. By comparing the Raman scattering intensity of the pyrene with that of the C18 chains in the stationary phase, it was possible to quantify the equilibrium coverage of pyrene relative to the C18 chains. Spectroscopic isotherms were measured to determine the saturation surface coverage of pyrene relative to C18 chains and to study how the preconcentration equilibrium can be controlled by the source-phase solution composition. For extraction from aqueous solutions having the lowest methanol concentration (5% by volume), the preconcentration factor for pyrene into the particle was found to be 4.8 (±0.8) × 10(4), which allowed detection of pyrene extracted from a 10 nM solution into a 0.52-pL particle volume.

  19. Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions

    Directory of Open Access Journals (Sweden)

    Wright Colin W

    2011-03-01

    Full Text Available Abstract Background In traditional medicine whole plants or mixtures of plants are used rather than isolated compounds. There is evidence that crude plant extracts often have greater in vitro or/and in vivo antiplasmodial activity than isolated constituents at an equivalent dose. The aim of this paper is to review positive interactions between components of whole plant extracts, which may explain this. Methods Narrative review. Results There is evidence for several different types of positive interactions between different components of medicinal plants used in the treatment of malaria. Pharmacodynamic synergy has been demonstrated between the Cinchona alkaloids and between various plant extracts traditionally combined. Pharmacokinetic interactions occur, for example between constituents of Artemisia annua tea so that its artemisinin is more rapidly absorbed than the pure drug. Some plant extracts may have an immunomodulatory effect as well as a direct antiplasmodial effect. Several extracts contain multidrug resistance inhibitors, although none of these has been tested clinically in malaria. Some plant constituents are added mainly to attenuate the side-effects of others, for example ginger to prevent nausea. Conclusions More clinical research is needed on all types of interaction between plant constituents. This could include clinical trials of combinations of pure compounds (such as artemisinin + curcumin + piperine and of combinations of herbal remedies (such as Artemisia annua leaves + Curcuma longa root + Piper nigum seeds. The former may enhance the activity of existing pharmaceutical preparations, and the latter may improve the effectiveness of existing herbal remedies for use in remote areas where modern drugs are unavailable.

  20. Hungary's U-Turn

    OpenAIRE

    Kornai, János

    2015-01-01

    For two decades Hungary, like the other Eastern European countries, followed a general policy of establishing and strengthening the institutions of democracy, rule of law, and a market economy based on private property. However, since the elections of 2010, when Viktor Orbán's Fidesz party came to power, Hungary has made a dramatic U-turn. This article investigates the different spheres of society: political institutions, the rule of law, and the influence of state and market on one another, ...

  1. Turning Desirements into Requirements

    Science.gov (United States)

    2015-09-01

    27 Defense AT&L: September–October 2015 Turning “Desirements” into Requirements Charles Court Court is the Requirements Center Director at the...Defense Systems Management College at the Defense Acquisition University at Fort Belvoir, Virginia. He is a former Wild Weasel Electronic Warfare Officer...a Mustang would do much better. (The author wanted the Aston Martin from the movie “Goldfinger.” You know: The one with the ejection seat, automated

  2. pH(stat) vs. single extraction tests to evaluate heavy metals and arsenic leachability in environmental samples.

    Science.gov (United States)

    Rigol, A; Mateu, J; González-Núñez, R; Rauret, G; Vidal, M

    2009-01-19

    Here we compared the pH(stat) test, which examines the leachability of major elements (Ca, Mg, Al, Fe, and Mn), dissolved organic carbon, and trace elements (Cd, Zn, Cu, Pb, and As) in a wide pH range, with single extraction tests based on the use of mild extractants (calcium chloride, acetic acid or EDTA). For this purpose, we examined samples from a variety of environmental conditions (sludges, mineral soils, organic soils, and soils with particulate and/or soluble contamination). Extraction yields obtained with CaCl(2) (0.01 mol L(-1)) and CH(3)COOH (0.43 mol L(-1)) correlated well with those from the pH(stat) at the same pH (r=0.98 and 0.95, respectively), while the use of EDTA (0.05 mol L(-1)) led to systematically higher extraction yields than those quantified with the pH(stat) at the same pH. However, the pH(stat) test had three distinct advantages: (1) it revealed the relationship between the solubility of the main soil phases and pH; (2) it showed the variation in pollutant leachability due to changes in pH; and (3) it better predicted the maximum contaminant availability. Thus we propose that the pH(stat) is the best laboratory tests to evaluate the contaminant leachability over a wide range of sample types (soil, sludge, and sediment).

  3. Single trial EEG classification applied to a face recognition experiment using different feature extraction methods.

    Science.gov (United States)

    Li, Yudu; Ma, Sen; Hu, Zhongze; Chen, Jiansheng; Su, Guangda; Dou, Weibei

    2015-01-01

    Research on brain machine interface (BMI) has been developed very fast in recent years. Numerous feature extraction methods have successfully been applied to electroencephalogram (EEG) classification in various experiments. However, little effort has been spent on EEG based BMI systems regarding familiarity of human faces cognition. In this work, we have implemented and compared the classification performances of four common feature extraction methods, namely, common spatial pattern, principal component analysis, wavelet transform and interval features. High resolution EEG signals were collected from fifteen healthy subjects stimulated by equal number of familiar and novel faces. Principal component analysis outperforms other methods with average classification accuracy reaching 94.2% leading to possible real life applications. Our findings thereby may contribute to the BMI systems for face recognition.

  4. Extraction of high-molecular-weight genomic DNA for long-read sequencing of single molecules.

    Science.gov (United States)

    Mayjonade, Baptiste; Gouzy, Jérôme; Donnadieu, Cécile; Pouilly, Nicolas; Marande, William; Callot, Caroline; Langlade, Nicolas; Muños, Stéphane

    2016-10-01

    De novo sequencing of complex genomes is one of the main challenges for researchers seeking high-quality reference sequences. Many de novo assemblies are based on short reads, producing fragmented genome sequences. Third-generation sequencing, with read lengths >10 kb, will improve the assembly of complex genomes, but these techniques require high-molecular-weight genomic DNA (gDNA), and gDNA extraction protocols used for obtaining smaller fragments for short-read sequencing are not suitable for this purpose. Methods of preparing gDNA for bacterial artificial chromosome (BAC) libraries could be adapted, but these approaches are time-consuming, and commercial kits for these methods are expensive. Here, we present a protocol for rapid, inexpensive extraction of high-molecular-weight gDNA from bacteria, plants, and animals. Our technique was validated using sunflower leaf samples, producing a mean read length of 12.6 kb and a maximum read length of 80 kb.

  5. The effect of selected plant extracts on the development of single-species dental biofilms

    International Nuclear Information System (INIS)

    Rahim, Z.H.; Shaikh, S.; Razak, A.; Ismail, W.N.H.W.

    2014-01-01

    To determine the effect of a mixture of plant extracts on the adherence and retention of bacteria in dental biofilm. Study Design: Experimental study. Place and Duration of Study:Department of Oral Biology, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia, from December 2009 to December 2011. Methodology: For determination of adhering ability, experimental pellicle was first treated with the Plant Extracts Mixture (PEM) before inoculating it with individual bacterial species ( S. mitis / S. sanguinis / S. mutans). For the determination of retention ability, the procedure was repeated with the experimental pellicle being inoculated first with the individual bacterial species and then treating it with the PEM. These two experiments were repeated with deionized distilled water (negative control) and Thymol (0.64%) (positive control). The bacterial populations in biofilms for the two experiments were expressed as Colony Forming Unit (CFU) / mL x 10/sup 4/ and the corresponding values were expressed as mean +- SD. Results: The effect of the Plant Extracts Mixture (PEM) for the two experiments was compared with that of Thymol and deionized distilled water. It was shown that there is a reduced adherence of bacteria to PEM-treated and Thymol (0.064%) treated experimental pellicle compared with the negative control (p < 0.001). It was also found that the retention of bacteria in both treated biofilms is also lower than that of negative control (p = 0.001). Conclusion: Plant Extracts Mixture (PEM) may influence the development of dental biofilm by affecting the adhering and retention capacities of the bacterial species in the dental biofilms. (author)

  6. Extraction Equilibrium of Dicarboxylic Acids with Tertiary Amine in Single and Binary Diluents

    Czech Academy of Sciences Publication Activity Database

    Procházka, Jaroslav; Heyberger, Aleš; Volaufová, Eva

    2004-01-01

    Roč. 39, č. 5 (2004), s. 1075-1093 ISSN 0149-6395. [CHISA 2000. Prague, 27.08.2000-31.08.2000] R&D Projects: GA ČR GA104/97/1213 Institutional research plan: CEZ:AV0Z4072921 Keywords : liquid extraction * dicarboxylic acids * tertiary amine Subject RIV: CI - Industrial Chemistry, Chemical Engineering Impact factor: 0.896, year: 2004

  7. Using the OSL single-aliquot regenerative-dose protocol with quartz extracted from building materials in retrospective dosimetry

    DEFF Research Database (Denmark)

    Bøtter-Jensen, L.; Solongo, S.; Murray, A.S.

    2000-01-01

    We report on the application of the single-aliquot regenerative-dose (SAR) protocol to the optically stimulated luminescence signal from quartz extracted from fired bricks acid unfired mortar in retrospective dosimetry. The samples came from a radioactive materials storage facility, with ambient...... dose rates of about 0.1 mGy/h. A detailed dose-depth profile was analysed from one brick, and compared with dose records from area TL dosemeters. Small-aliquot dose-distributions were analysed from the mortar samples; one associated with the exposed brick, and one from a remote site exposed only...

  8. Synthesis of single-phase L10-FeNi magnet powder by nitrogen insertion and topotactic extraction

    OpenAIRE

    Goto, Sho; Kura, Hiroaki; Watanabe, Eiji; Hayashi, Yasushi; Yanagihara, Hideto; Shimada, Yusuke; Mizuguchi, Masaki; Takanashi, Koki; Kita, Eiji

    2017-01-01

    Tetrataenite (L10-FeNi) is a promising candidate for use as a permanent magnet free of rare-earth elements because of its favorable properties. In this study, single-phase L10-FeNi powder with a high degree of order was synthesized through a new method, nitrogen insertion and topotactic extraction (NITE). In the method, FeNiN, which has the same ordered arrangement as L10-FeNi, is formed by nitriding A1-FeNi powder with ammonia gas. Subsequently, FeNiN is denitrided by topotactic reaction to ...

  9. Calculation of injection and extraction orbits for the IPCR SSC

    International Nuclear Information System (INIS)

    Goto, A.; Yano, Y.; Kishida, N.; Nakanishi, N.; Wada, T.

    1982-01-01

    Calculations of beam trajectories in the injection and extraction systems for the IPCR SSC were done and the characteristics of those elements were determined. Beam centering for single turn extraction by use of first harmonic fields were also studied. The rather simple conditions at the injection point for a well-centered acceleration orbit are also discussed

  10. Turning scar into muscle.

    Science.gov (United States)

    de Carvalho, Antonio Carlos Campos; Carvalho, Adriana Bastos

    2012-09-26

    After the demonstration that somatic cells could be reprogrammed to a pluripotent state, exciting new prospects were opened for the cardiac regeneration field. It did not take long for the development of strategies to convert somatic cells directly into cardiomyocytes. Despite the intrinsic difficulties of cell reprogramming, such as low efficiency, the therapeutic possibilities created by the ability to turn scar into muscle are enormous. Here, we discuss some of the major advances and strategies used in direct cardiac reprogramming and examine discrepancies and concerns that still need to be resolved in the field.

  11. A single extraction and HPLC procedure for simultaneous analysis of phytosterols, tocopherols and lutein in soybeans.

    Science.gov (United States)

    Slavin, Margaret; Yu, Liangli Lucy

    2012-12-15

    A saponification/extraction procedure and high performance liquid chromatography (HPLC) analysis method were developed and validated for simultaneous analysis of phytosterols, tocopherols and lutein (a carotenoid) in soybeans. Separation was achieved on a phenyl column with a ternary, isocratic solvent system of acetonitrile, methanol and water (48:22.5:29.5, v/v/v). Evaporative light scattering detection (ELSD) was used to quantify β-sitosterol, stigmasterol, campesterol, and α-, δ- and γ-tocopherols, while lutein was quantified with visible light absorption at 450 nm. Peak identification was verified by retention times and spikes with external standards. Standard curves were constructed (R(2)>0.99) to allow for sample quantification. Recovery of the saponification and extraction was demonstrated via analysis of spiked samples. Also, the accuracy of results of four soybeans using the described saponification and HPLC analytical method was validated against existing methods. This method offers a more efficient alternative to individual methods for quantifying lutein, tocopherols and sterols in soybeans. Copyright © 2012 Elsevier Ltd. All rights reserved.

  12. Algorithm for extracting multiple object waves without Fourier transform from a single image recorded by spatial frequency-division multiplexing and its application to digital holography

    Science.gov (United States)

    Tahara, Tatsuki; Akamatsu, Takanori; Arai, Yasuhiko; Shimobaba, Tomoyoshi; Ito, Tomoyoshi; Kakue, Takashi

    2017-11-01

    We propose a novel algorithm that does not require any Fourier transform to extract multiple object waves in a single image recorded with spatial frequency-division multiplexing. Smoothing is utilized to extract the desired object-wave information from a spatially multiplexed image. Numerical and experimental results show its validity and applicability for image and Fresnel digital holography. Our investigations clarify the speeding up of both the object-wave extractions and multiple object-image reconstructions quantitatively.

  13. Direct immersion single drop micro-extraction method for multi-class pesticides analysis in mango using GC-MS.

    Science.gov (United States)

    Pano-Farias, Norma S; Ceballos-Magaña, Silvia G; Muñiz-Valencia, Roberto; Jurado, Jose M; Alcázar, Ángela; Aguayo-Villarreal, Ismael A

    2017-12-15

    Due the negative effects of pesticides on environment and human health, more efficient and environmentally friendly methods are needed. In this sense, a simple, fast, free from memory effects and economical direct-immersion single drop micro-extraction (SDME) method and GC-MS for multi-class pesticides determination in mango samples was developed. Sample pre-treatment using ultrasound-assisted solvent extraction and factors affecting the SDME procedure (extractant solvent, drop volume, stirring rate, ionic strength, time, pH and temperature) were optimized using factorial experimental design. This method presented high sensitive (LOD: 0.14-169.20μgkg -1 ), acceptable precision (RSD: 0.7-19.1%), satisfactory recovery (69-119%) and high enrichment factors (20-722). Several obtained LOQs are below the MRLs established by the European Commission; therefore, the method could be applied for pesticides determination in routing analysis and custom laboratories. Moreover, this method has shown to be suitable for determination of some of the studied pesticides in lime, melon, papaya, banana, tomato, and lettuce. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. {open_quotes}Optical guiding{close_quotes} limits on extraction efficiencies of single-pass, tapered wiggler amplifiers

    Energy Technology Data Exchange (ETDEWEB)

    Fawley, W.M. [Lawrence Berkeley Lab., CA (United States)

    1995-12-31

    Single-pass, tapered wiggler amplifiers have an attractive feature of being able, in theory at least, of extracting a large portion of the electron beam energy into light. In circumstances where an optical FEL`s wiggler length is significantly longer than the Rayleigh length Z{sub R} corresponding to the electron beam radius, diffraction losses must be controlled via the phenomenon of {open_quotes}optical guiding{close_quotes}. Since the strength of the guiding depends upon the effective refractive index {eta}{sub r} exceeding one, and since ({eta}{sub r}-1) is inversely proportional to the optical electric field, there is a natural {open_quotes}limiting{close_quotes} mechanism to the on-axis field strength and thus the rate at which energy may be extracted from the electron beam. In particular, the extraction efficiency for a prebunched beam asymptotically grows linearly with z rather than quadratically. We present analytical and numerical simulation results concerning this behavior and discuss its applicability to various FEL designs including oscillator/amplifier-radiator configurations.

  15. A Simple Fractionated Extraction Method for the Comprehensive Analysis of Metabolites, Lipids, and Proteins from a Single Sample.

    Science.gov (United States)

    Salem, Mohamed; Bernach, Michal; Bajdzienko, Krzysztof; Giavalisco, Patrick

    2017-06-01

    Understanding of complex biological systems requires the measurement, analysis and integration of multiple compound classes of the living cell, usually determined by transcriptomic, proteomic, metabolomics and lipidomic measurements. In this protocol, we introduce a simple method for the reproducible extraction of metabolites, lipids and proteins from biological tissues using a single aliquot per sample. The extraction method is based on a methyl tert-butyl ether: methanol: water system for liquid: liquid partitioning of hydrophobic and polar metabolites into two immiscible phases along with the precipitation of proteins and other macromolecules as a solid pellet. This method, therefore, provides three different fractions of specific molecular composition, which are fully compatible with common high throughput 'omics' technologies such as liquid chromatography (LC) or gas chromatography (GC) coupled to mass spectrometers. Even though the method was initially developed for the analysis of different plant tissue samples, it has proved to be fully compatible for the extraction and analysis of biological samples from systems as diverse as algae, insects, and mammalian tissues and cell cultures.

  16. Torsion of a Subserosal Myoma Managed by Gasless Laparoendoscopic Single-Site Myomectomy with In-Bag Manual Extraction

    Directory of Open Access Journals (Sweden)

    Akihiro Takeda

    2016-01-01

    Full Text Available Acute torsion of a subserosal myoma is a rare surgical emergency that is infrequently diagnosed preoperatively. Furthermore, laparoendoscopic single-site (LESS myomectomy with in-bag tissue extraction for the management of this disorder has not yet been described. A 43-year-old, gravida 1, para 1 woman was referred to our department due to a solid pelvic mass associated with persistent abdominal pain. A pedunculated subserosal myoma with torsion was strongly suspected based on ultrasonography and magnetic resonance imaging. Emergency LESS surgery showed that the subserosal myoma arising from the posterior uterine wall torted at its pedicle in the cul-de-sac. The twisted myoma node was excised by coagulation and cut using a LigaSure Atlas, followed by in-bag manual morcellation and extraction through an umbilical wound. The present case report emphasizes that LESS myomectomy with in-bag tissue extraction is a feasible minimally invasive surgical option for the management of subserosal myoma with torsion after a precise imaging-based diagnostic evaluation.

  17. Tissue Dimensional Changes in Single-Tooth Immediate Extraction Implant Placement in the Esthetic Zone: A Retrospective Clinical Study.

    Science.gov (United States)

    Amato, Francesco; Polara, Giorgio; Spedicato, Giorgio Alfredo

    The aim of this study was to evaluate the buccopalatal volumetric tissue change that occurs following flapless single-tooth immediate extraction placement in the esthetic area and to analyze the role of four different variables. Patients in need of a single-tooth replacement in the anterior maxillary or mandibular area (premolar to premolar) were recruited for the study. Patients were treated using four different therapeutic modalities: group 1 (healing abutment), group 2 (healing abutment + bone graft), group 3 (provisional restoration), and group 4 (provisional + bone graft). Alginate impressions were taken the day of implant insertion before tooth extraction (T0), at 1 month (T1), at 3 months (T2), and at 6 months (T3). Buccopalatal dimension (BPD) was measured on the study casts at 1, 3, and 5 mm apical to the free gingival margin and compared between T0 and T1 and T2 and T3. Seventy-seven patients were included in the study, 29 men and 48 women with a mean age of 54 years (range: 24 to 76 years), and 80 implants were inserted. Thirteen implants were inserted in group 1, 13 in group 2, 20 in group 3, and 34 in group 4. The BPD contraction was more evident for group 1, smaller in group 2 and group 3, and minimal in group 4. Repeated measures analysis of variance (ANOVA) and post hoc tests were used. The data analyzed were considered statistically significant with a level of α = .05. The interaction effect P value was numerically zero. The results of this study seem to indicate that volumetric tissue changes after immediate extraction placement in the esthetic area can be minimized if a provisional is immediately connected and a bone graft is inserted simultaneously.

  18. Fermilab turns 50! Congratulations!

    CERN Multimedia

    Staff Association

    2017-01-01

    This year Fermilab turns 50 and the celebrations are ongoing. The ties between CERN and Fermilab are numerous and have been ranging from competition between two labs at the forefront of their field, e.g. with the chase of the top quark, finally discovered by Fermilab, to outright collaboration, e.g. on LHC low-beta quadrupole magnet development and production and in the CMS collaboration. In June, in the name of the CERN staff and scientific community, the CERN Staff Association sent a message to the Fermilab staff and scientific community, through Dr. Nigel Lockyer, Fermilab Director. The letter, and the assurance from Nigel Lockyer that the message has been passed onto the Fermilab community can be found on our website. Congratulations to Fermilab on its fiftieth Anniversary, and to the staff and collaborators who made this laboratory through their hard work, dedication and vision!

  19. The Affective Turn

    Directory of Open Access Journals (Sweden)

    Alí Lara

    2013-11-01

    Full Text Available In the last decade studies on affect and emotions have become relevant in the social sciences. This is not just a fad guideline, but instead a simultaneous reader of public life changes and subjective experience, from which it is also being transformed the knowledge production. Such a trend has been known as ‘The Affective Turn’ within the Anglophone Academy. Here we will translate it as ‘El Giro Afectivo’. This turn, so far, has not dabbled in the social science literature that is written in Spanish. This paper draws on a singular panorama of discussions about contemporary social studies of affect and emotion, and it’s vertebrate by some of its expressions in the contemporary academy.

  20. Robust organelle size extractions from elastic scattering measurements of single cells (Conference Presentation)

    Science.gov (United States)

    Cannaday, Ashley E.; Draham, Robert; Berger, Andrew J.

    2016-04-01

    The goal of this project is to estimate non-nuclear organelle size distributions in single cells by measuring angular scattering patterns and fitting them with Mie theory. Simulations have indicated that the large relative size distribution of organelles (mean:width≈2) leads to unstable Mie fits unless scattering is collected at polar angles less than 20 degrees. Our optical system has therefore been modified to collect angles down to 10 degrees. Initial validations will be performed on polystyrene bead populations whose size distributions resemble those of cell organelles. Unlike with the narrow bead distributions that are often used for calibration, we expect to see an order-of-magnitude improvement in the stability of the size estimates as the minimum angle decreases from 20 to 10 degrees. Scattering patterns will then be acquired and analyzed from single cells (EMT6 mouse cancer cells), both fixed and live, at multiple time points. Fixed cells, with no changes in organelle sizes over time, will be measured to determine the fluctuation level in estimated size distribution due to measurement imperfections alone. Subsequent measurements on live cells will determine whether there is a higher level of fluctuation that could be attributed to dynamic changes in organelle size. Studies on unperturbed cells are precursors to ones in which the effects of exogenous agents are monitored over time.

  1. Techniques for extracting single-trial activity patterns from large-scale neural recordings

    Science.gov (United States)

    Churchland, Mark M; Yu, Byron M; Sahani, Maneesh; Shenoy, Krishna V

    2008-01-01

    Summary Large, chronically-implanted arrays of microelectrodes are an increasingly common tool for recording from primate cortex, and can provide extracellular recordings from many (order of 100) neurons. While the desire for cortically-based motor prostheses has helped drive their development, such arrays also offer great potential to advance basic neuroscience research. Here we discuss the utility of array recording for the study of neural dynamics. Neural activity often has dynamics beyond that driven directly by the stimulus. While governed by those dynamics, neural responses may nevertheless unfold differently for nominally identical trials, rendering many traditional analysis methods ineffective. We review recent studies – some employing simultaneous recording, some not – indicating that such variability is indeed present both during movement generation, and during the preceding premotor computations. In such cases, large-scale simultaneous recordings have the potential to provide an unprecedented view of neural dynamics at the level of single trials. However, this enterprise will depend not only on techniques for simultaneous recording, but also on the use and further development of analysis techniques that can appropriately reduce the dimensionality of the data, and allow visualization of single-trial neural behavior. PMID:18093826

  2. Salient Region Detection by Fusing Foreground and Background Cues Extracted from Single Image

    Directory of Open Access Journals (Sweden)

    Qiangqiang Zhou

    2016-01-01

    Full Text Available Saliency detection is an important preprocessing step in many application fields such as computer vision, robotics, and graphics to reduce computational cost by focusing on significant positions and neglecting the nonsignificant in the scene. Different from most previous methods which mainly utilize the contrast of low-level features, various feature maps are fused in a simple linear weighting form. In this paper, we propose a novel salient object detection algorithm which takes both background and foreground cues into consideration and integrate a bottom-up coarse salient regions extraction and a top-down background measure via boundary labels propagation into a unified optimization framework to acquire a refined saliency detection result. Wherein the coarse saliency map is also fused by three components, the first is local contrast map which is in more accordance with the psychological law, the second is global frequency prior map, and the third is global color distribution map. During the formation of background map, first we construct an affinity matrix and select some nodes which lie on border as labels to represent the background and then carry out a propagation to generate the regional background map. The evaluation of the proposed model has been implemented on four datasets. As demonstrated in the experiments, our proposed method outperforms most existing saliency detection models with a robust performance.

  3. Turning Sunlight into Electricity

    Indian Academy of Sciences (India)

    module' or a 'solar panel' that provides a useful voltage and current. The efficiency of silicon solar cells for the conversion of light energy to electricity has increased steadily over the years to present values of up to 18% for amorphous silicon, and 25% for single crystal cells. At the same time, the cost of cells has fallen.

  4. Copper hexacyanoferrate functionalized single-walled carbon nano-tubes for selective cesium extraction

    International Nuclear Information System (INIS)

    Draouil, H.; Alvarez, L.; Bantignies, J.L.; Causse, J.; Cambedouzou, J.; Flaud, V.; Zaibi, M.A.; Oueslati, M.

    2017-01-01

    Single-walled carbon nano-tubes (SWCNTs) are functionalized with copper hexacyanoferrate (CuHCF) nanoparticles to prepare solid substrates for sorption of cesium ions (Cs + ) from liquid outflows. The high mechanical resistance and large electrical conductivity of SWCNTs are associated with the ability of CuHCF nanoparticles to selectively complex Cs + ions in order to achieve membrane-like buckypapers presenting high loading capacity of cesium. The materials are thoroughly characterized using electron microscopy, Raman scattering, X-ray photoelectron spectroscopy and thermogravimetric analyses. Cs sorption isotherms are plotted after having measured the Cs + concentration by liquid phase ionic chromatography in the solution before and after exposure to the materials. It is found that the total sorption capacity of the material reaches 230 mg.g -1 , and that about one third of the sorbed Cs (80 mg.g -1 ) is selectively complexed in the CuHCF nanoparticles grafted on SWCNTs. The quantification of Cs + ions on different sorption sites is made for the first time, and the high sorption rates open interesting outlooks in the integration of such materials in devices for the controlled sorption and desorption of these ions. (authors)

  5. A Systematic Review on Effect of Single-Dose Preoperative Antibiotics at Surgical Osteotomy Extraction of Lower Third Molars

    DEFF Research Database (Denmark)

    Marcussen, Karoline Brørup; Laulund, Anne Sofie; Jørgensen, Henrik L

    2016-01-01

    PURPOSE: We conducted a systematic review of randomized controlled trials (RCTs) to evaluate the effectiveness of a single dose of preoperative antibiotic administered perorally, intravenously, intramuscularly, or topically for preventing infection and alveolar osteitis in lower third molar...... surgical extraction implying osteotomy. MATERIALS AND METHODS: The Medline, Cochrane Library, and Embase databases were searched for RCTs until August 2015. The primary outcome measure was postoperative inflammatory reactions, with a subgroup analysis of surgical site infection (SSI) and alveolar osteitis.......08 to 0.45; P = .0002). A meta-analysis of 5 trials showed that 2 g of preoperative oral amoxicillin was able to reduce the incidence of SSI and the difference was statistically significant (OR = 0.22; 95% CI, 0.08 to 0.59; P = .002). Seven trials reported on alveolar osteitis, 6 studies on oral use, 2...

  6. A Online NIR Sensor for the Pilot-Scale Extraction Process in Fructus Aurantii Coupled with Single and Ensemble Methods

    Directory of Open Access Journals (Sweden)

    Xiaoning Pan

    2015-04-01

    Full Text Available Model performance of the partial least squares method (PLS alone and bagging-PLS was investigated in online near-infrared (NIR sensor monitoring of pilot-scale extraction process in Fructus aurantii. High-performance liquid chromatography (HPLC was used as a reference method to identify the active pharmaceutical ingredients: naringin, hesperidin and neohesperidin. Several preprocessing methods and synergy interval partial least squares (SiPLS and moving window partial least squares (MWPLS variable selection methods were compared. Single quantification models (PLS and ensemble methods combined with partial least squares (bagging-PLS were developed for quantitative analysis of naringin, hesperidin and neohesperidin. SiPLS was compared to SiPLS combined with bagging-PLS. Final results showed the root mean square error of prediction (RMSEP of bagging-PLS to be lower than that of PLS regression alone. For this reason, an ensemble method of online NIR sensor is here proposed as a means of monitoring the pilot-scale extraction process in Fructus aurantii, which may also constitute a suitable strategy for online NIR monitoring of CHM.

  7. From soil to leaves--aluminum fractionation by single step extraction procedures in polluted and protected areas.

    Science.gov (United States)

    Frankowski, Marcin; Zioła-Frankowska, Anetta; Siepak, Jerzy

    2013-09-30

    The paper presents the fractionation of aluminum in the samples of soil and plants of different species using a selective single-step extraction method. The study was conducted in the area located near a chemical plant, which for many years served as a post-crystallization leachate disposal site storing chemical waste (sector I), and in the area around the site: in Wielkopolski National Park, Rogalin Landscape Park and toward the infiltration ponds at the "Dębina" groundwater well-field for the city of Poznań (Poland) (sector II). The results of aluminum fractionation in samples of soil, leaves and plants showed heavy pollution with aluminum, especially in the water soluble aluminum fraction - Alsw (maximum concentration of aluminum in soil extract was 234.8 ± 4.8 mg kg(-1), in the leaves of Betula pendula it was 107.4 ± 1.8 mg kg(-1) and in the plants of Artemisia vulgaris (root) and Medicago sativa (leaves) it amounted to 464.7 ± 10.7 mg kg(-1)and 146.8 ± 1.2 mg kg(-1) respectively). In addition, the paper presents the problem of organic aluminum fractionation in biological samples and it shows the relationship between aluminum concentration in soil and the analysed woody and herbaceous species. Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. Observing dynamics of chromatin fibers in Xenopus egg extracts by single DNA manipulation using a transverse magnetic tweezer setup

    Science.gov (United States)

    Yan, Jie; Skoko, Dunja; Marko, John; Maresca, Tom; Heald, Rebecca

    2005-03-01

    We have studied assembly of chromatin on single DNAs using Xenopus egg extracts and a specially designed magnetic tweezer setup which generates controlled force in the focal plane of the objective, allowing us to visualize and measure DNA extension under a wide range of constant tensions. We found, in the absence of ATP, interphase extracts assembled nucleosomes against DNA tensions of up to 3.5 piconewtons (pN). We observed force-induced disassembly and opening-closing fluctuations indicating our experiments were in mechano-chemical equilibrium. We found that the ATP-depleted reaction can do mechanical work of 27 kcal/mol per nucleosome, providing a measurement of the free energy difference between core histone octamers on and off DNA. Addition of ATP leads to highly dynamic behavior: time courses show processive runs of assembly and disassembly of not observed in the -ATP case, with forces of 2 pN leading to nearly complete fiber disassembly. Our study shows that ATP hydrolysis plays a major role in nucleosome rearrangement and removal, and suggests that chromatin in vivo may be subject to continual assembly and disassembly.

  9. Turn Continuation and Clause Combinations

    Science.gov (United States)

    Couper-Kuhlen, Elizabeth

    2012-01-01

    This article explores the viability of the analytic distinction between "turn-constructional unit (TCU) continuation" (i.e., continuing a turn beyond a point of possible completion with grammatically dependent material) and "new TCU" (i.e., continuing a turn with grammatically independent material) when hypotactic clause combinations are involved.…

  10. Turning to the wind

    Science.gov (United States)

    Sorensen, B.

    1981-10-01

    Consideration is given the economic and technological aspects of both free-stream (horizontal-axis) and cross-wind (vertical-axis) wind energy conversion systems, with attention to operational devices ranging in rotor diameter from 10 to 40 m and in output from 22 to 630 kW. After a historical survey of wind turbine design and applications development, the near-term technical feasibility and economic attractiveness of combined wind/fossil-fueled generator and wind/hydroelectric systems are assessed. Also presented are estimates of wind energy potential extraction in the U.S. and Denmark, the industrial requirements of large-scale implementation, energy storage possibilities such as pumped hydro and flywheels, and cost comparisons of electrical generation by large and small wind systems, coal-fired plants, and light-water fission reactors.

  11. Synthesis of single-phase L10-FeNi magnet powder by nitrogen insertion and topotactic extraction.

    Science.gov (United States)

    Goto, Sho; Kura, Hiroaki; Watanabe, Eiji; Hayashi, Yasushi; Yanagihara, Hideto; Shimada, Yusuke; Mizuguchi, Masaki; Takanashi, Koki; Kita, Eiji

    2017-10-16

    Tetrataenite (L1 0 -FeNi) is a promising candidate for use as a permanent magnet free of rare-earth elements because of its favorable properties. In this study, single-phase L1 0 -FeNi powder with a high degree of order was synthesized through a new method, nitrogen insertion and topotactic extraction (NITE). In the method, FeNiN, which has the same ordered arrangement as L1 0 -FeNi, is formed by nitriding A1-FeNi powder with ammonia gas. Subsequently, FeNiN is denitrided by topotactic reaction to derive single-phase L1 0 -FeNi with an order parameter of 0.71. The transformation of disordered-phase FeNi into the L1 0 phase increased the coercive force from 14.5 kA/m to 142 kA/m. The proposed method not only significantly accelerates the development of magnets using L1 0 -FeNi but also offers a new synthesis route to obtain ordered alloys in non-equilibrium states.

  12. Tissue stability of implants placed in fresh extraction sockets: a 5-year prospective single-cohort study.

    Science.gov (United States)

    Covani, Ugo; Canullo, Luigi; Toti, Paolo; Alfonsi, Fortunato; Barone, Antonio

    2014-09-01

    Several materials have been used for ridge preservation after tooth extraction. This 5-year prospective single-cohort study is aimed at evaluating the success rate, marginal bone level (MBL), soft tissue stability, and subjective patient evaluation of implants placed in fresh extraction sockets with the use of a flapless technique and a xenograft to treat the peri-implant bone defect. Patients requiring a single implant in fresh extraction sockets were selected. After flapless extraction and implant insertion, the peri-implant bone defect was grafted with porcine bone. Collagen membrane was used to stabilize the graft. Four months later, a second surgery and prosthetic procedures were performed. Clinical parameters (width of keratinized gingiva [WKG], facial soft tissue level [FST], papilla index, plaque index, and bleeding on probing) were measured, and periapical radiographs were taken at the time of implant placement (baseline) and then at 1, 3, and 5 years thereafter. Image analysis software was applied to measure changes in the marginal bone level (ΔMBL). Additionally, patient satisfaction regarding the implant treatment was evaluated. All analyses were collected and measured by an independent, trained observer. Together with descriptive statistics, for each of the outcome variables, pairwise comparisons were performed using the Wilcoxon signed-rank test for matched samples. The level of statistical significance was set at 0.01 for all analyses. Forty-seven consecutive patients were treated, with an implant survival rate at 5 years of 95.7%. ΔMBL showed statistically significant differences: mean values were -0.68 ± 0.39, -0.94 ± 0.44, and -1.08 ± 0.43 mm at the 1, 3, and 5-year follow-up, respectively. Changes in WKG (ΔWKG) and FST (ΔFST) decreased from the 1-year point of the survey (0.80 ± 0.79 and 0.71 ± 0.73 mm for ΔWKG and ΔFST, respectively) to the last follow-up check at 5 years (0.67 ± 0.74 and 0.56 ± 0.69 mm for ΔWKG and

  13. Combination of electromembrane extraction and liquid-phase microextraction in a single step: Simultaneous group separation of acidic and basic drugs

    DEFF Research Database (Denmark)

    Huang, Chuixiu; Seip, Knut Fredrik; Gjelstad, Astrid

    2015-01-01

    Electromembrane extraction (EME) and liquid-phase microextraction (LPME) were combined in a single step for the first time to realize simultaneous and clear group separation of basic and acidic drugs. Using 2-nitrophenyl octyl ether as the supported liquid membrane (SLM) for EME and dihexyl ether...... as the SLM for LPME, basic and acidic drugs were extracted and separated simultaneously from a low pH sample by EME and LPME, respectively. After 15 min of extraction, basic drugs (citalopram and sertraline) were exhaustively extracted, whereas the recoveries for acidic drugs (ketoprofen and ibuprofen) were...... in the range of 76%-86%. Longer extraction time provided higher recoveries for the acidic drugs, but this somewhat deteriorated the group separation. Matrices effects from the coexisting acidic drugs/basic drugs were tested, and we observed that simultaneous EME/LPME was not affected by coexisting drugs...

  14. Motion blur filtering: A statistical approach for extracting confinement forces and diffusivity from a single blurred trajectory

    Science.gov (United States)

    Calderon, Christopher P.

    2016-05-01

    Single particle tracking (SPT) can aid in understanding a variety of complex spatiotemporal processes. However, quantifying diffusivity and confinement forces from individual live cell trajectories is complicated by inter- and intratrajectory kinetic heterogeneity, thermal fluctuations, and (experimentally resolvable) statistical temporal dependence inherent to the underlying molecule's time correlated confined dynamics experienced in the cell. The problem is further complicated by experimental artifacts such as localization uncertainty and motion blur. The latter is caused by the tagged molecule emitting photons at different spatial positions during the exposure time of a single frame. The aforementioned experimental artifacts induce spurious time correlations in measured SPT time series that obscure the information of interest (e.g., confinement forces and diffusivity). We develop a maximum likelihood estimation (MLE) technique that decouples the above noise sources and systematically treats temporal correlation via time series methods. This ultimately permits a reliable algorithm for extracting diffusivity and effective forces in confined or unconfined environments. We illustrate how our approach avoids complications inherent to mean square displacement or autocorrelation techniques. Our algorithm modifies the established Kalman filter (which does not handle motion blur artifacts) to provide a likelihood based time series estimation procedure. The result extends A. J. Berglund's motion blur model [Phys. Rev. E 82, 011917 (2010), 10.1103/PhysRevE.82.011917] to handle confined dynamics. The approach can also systematically utilize (possibly time dependent) localization uncertainty estimates afforded by image analysis if available. This technique, which explicitly treats confinement and motion blur within a time domain MLE framework, uses an exact likelihood (time domain methods facilitate analyzing nonstationary signals). Our estimator is demonstrated to be

  15. Sandstone Turning by Abrasive Waterjet

    Czech Academy of Sciences Publication Activity Database

    Hlaváček, Petr; Cárach, J.; Hloch, Sergej; Vasilko, K.; Klichová, Dagmar; Klich, Jiří; Lehocká, D.

    2015-01-01

    Roč. 48, č. 6 (2015), s. 2489-2493 ISSN 0723-2632 R&D Projects: GA MŠk ED2.1.00/03.0082; GA MŠk(CZ) LO1406 Institutional support: RVO:68145535 Keywords : turning away from the jet * conventional turning towards the jet * sandstone * abrasive water jet Subject RIV: JQ - Machines ; Tools Impact factor: 2.386, year: 2015 http://www.springerprofessional.de/sandstone-turning-by-abrasive-waterjet/6038028.html

  16. Sandstone Turning by Abrasive Waterjet

    Czech Academy of Sciences Publication Activity Database

    Hlaváček, Petr; Cárach, J.; Hloch, Sergej; Vasilko, K.; Klichová, Dagmar; Klich, Jiří; Lehocká, D.

    2015-01-01

    Roč. 48, č. 6 (2015), s. 2489-2493 ISSN 0723-2632 R&D Projects: GA MŠk ED2.1.00/03.0082; GA MŠk(CZ) LO1406 Institutional support: RVO:68145535 Keywords : turning away from the jet * conventional turning towards the jet * sandstone * abrasive water jet Subject RIV: JQ - Machines ; Tools Impact factor: 2.386, year: 2015 http://www.springerprofessional.de/sandstone-turning-by-abrasive- water jet/6038028.html

  17. Sequential Total Variation Denoising for the Extraction of Fetal ECG from Single-Channel Maternal Abdominal ECG.

    Science.gov (United States)

    Lee, Kwang Jin; Lee, Boreom

    2016-07-01

    Fetal heart rate (FHR) is an important determinant of fetal health. Cardiotocography (CTG) is widely used for measuring the FHR in the clinical field. However, fetal movement and blood flow through the maternal blood vessels can critically influence Doppler ultrasound signals. Moreover, CTG is not suitable for long-term monitoring. Therefore, researchers have been developing algorithms to estimate the FHR using electrocardiograms (ECGs) from the abdomen of pregnant women. However, separating the weak fetal ECG signal from the abdominal ECG signal is a challenging problem. In this paper, we propose a method for estimating the FHR using sequential total variation denoising and compare its performance with that of other single-channel fetal ECG extraction methods via simulation using the Fetal ECG Synthetic Database (FECGSYNDB). Moreover, we used real data from PhysioNet fetal ECG databases for the evaluation of the algorithm performance. The R-peak detection rate is calculated to evaluate the performance of our algorithm. Our approach could not only separate the fetal ECG signals from the abdominal ECG signals but also accurately estimate the FHR.

  18. Sequential Total Variation Denoising for the Extraction of Fetal ECG from Single-Channel Maternal Abdominal ECG

    Directory of Open Access Journals (Sweden)

    Kwang Jin Lee

    2016-07-01

    Full Text Available Fetal heart rate (FHR is an important determinant of fetal health. Cardiotocography (CTG is widely used for measuring the FHR in the clinical field. However, fetal movement and blood flow through the maternal blood vessels can critically influence Doppler ultrasound signals. Moreover, CTG is not suitable for long-term monitoring. Therefore, researchers have been developing algorithms to estimate the FHR using electrocardiograms (ECGs from the abdomen of pregnant women. However, separating the weak fetal ECG signal from the abdominal ECG signal is a challenging problem. In this paper, we propose a method for estimating the FHR using sequential total variation denoising and compare its performance with that of other single-channel fetal ECG extraction methods via simulation using the Fetal ECG Synthetic Database (FECGSYNDB. Moreover, we used real data from PhysioNet fetal ECG databases for the evaluation of the algorithm performance. The R-peak detection rate is calculated to evaluate the performance of our algorithm. Our approach could not only separate the fetal ECG signals from the abdominal ECG signals but also accurately estimate the FHR.

  19. Sequential Total Variation Denoising for the Extraction of Fetal ECG from Single-Channel Maternal Abdominal ECG

    Science.gov (United States)

    Lee, Kwang Jin; Lee, Boreom

    2016-01-01

    Fetal heart rate (FHR) is an important determinant of fetal health. Cardiotocography (CTG) is widely used for measuring the FHR in the clinical field. However, fetal movement and blood flow through the maternal blood vessels can critically influence Doppler ultrasound signals. Moreover, CTG is not suitable for long-term monitoring. Therefore, researchers have been developing algorithms to estimate the FHR using electrocardiograms (ECGs) from the abdomen of pregnant women. However, separating the weak fetal ECG signal from the abdominal ECG signal is a challenging problem. In this paper, we propose a method for estimating the FHR using sequential total variation denoising and compare its performance with that of other single-channel fetal ECG extraction methods via simulation using the Fetal ECG Synthetic Database (FECGSYNDB). Moreover, we used real data from PhysioNet fetal ECG databases for the evaluation of the algorithm performance. The R-peak detection rate is calculated to evaluate the performance of our algorithm. Our approach could not only separate the fetal ECG signals from the abdominal ECG signals but also accurately estimate the FHR. PMID:27376296

  20. Turning patients over in bed

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000426.htm Turning patients over in bed To use the sharing features on this page, ... Patient The following steps should be followed when turning a patient: If you can, raise the bed to a level that reduces back strain for ...

  1. Evaluation of the Single Dilute (0.43 M) Nitric Acid Extraction to Determine Geochemically Reactive Elements in Soil

    NARCIS (Netherlands)

    Groenenberg, Jan E.; Römkens, Paul F.A.M.; Zomeren, van André; Rodrigues, S.M.; Comans, Rob N.J.

    2017-01-01

    Recently a dilute nitric acid extraction (0.43 M) was adopted by ISO (ISO-17586:2016) as standard for extraction of geochemically reactive elements in soil and soil like materials. Here we evaluate the performance of this extraction for a wide range of elements by mechanistic geochemical

  2. Effect of Dangguibohyul-Tang, a Mixed Extract of Astragalus membranaceus and Angelica sinensis, on Allergic and Inflammatory Skin Reaction Compared with Single Extracts of Astragalus membranaceus or Angelica sinensis

    Directory of Open Access Journals (Sweden)

    You Yeon Choi

    2016-01-01

    Full Text Available Dangguibohyul-tang (DBT, herbal formula composed of Astragalus membranaceus (AM and Angelica sinensis (AS at a ratio of 5 : 1, has been used for the treatment of various skin diseases in traditional medicine. We investigated the effect of DBT on allergic and inflammatory skin reaction in atopic dermatitis-like model compared to the single extract of AM or AS. DBT treatment showed the remission of clinical symptoms, including decreased skin thickness and scratching behavior, the total serum IgE level, and the number of mast cells compared to DNCB group as well as the single extract of AM- or AS-treated group. Levels of cytokines (IL-4, IL-6, IFN-γ, TNF-α, and IL-1β and inflammatory mediators (NF-κB, phospho-IκBα, and phospho-MAPKs were significantly decreased in AM, AS, and DBT groups. These results demonstrated that AM, AS, and DBT may have the therapeutic property on atopic dermatitis by inhibition of allergic and inflammatory mediators and DBT formula; a mixed extract of AM and AS based on the herb pairs theory especially might be more effective on antiallergic reaction as compared with the single extract of AM or AS.

  3. Extracting time-frequency feature of single-channel vastus medialis EMG signals for knee exercise pattern recognition.

    Science.gov (United States)

    Zhang, Yi; Li, Peiyang; Zhu, Xuyang; Su, Steven W; Guo, Qing; Xu, Peng; Yao, Dezhong

    2017-01-01

    The EMG signal indicates the electrophysiological response to daily living of activities, particularly to lower-limb knee exercises. Literature reports have shown numerous benefits of the Wavelet analysis in EMG feature extraction for pattern recognition. However, its application to typical knee exercises when using only a single EMG channel is limited. In this study, three types of knee exercises, i.e., flexion of the leg up (standing), hip extension from a sitting position (sitting) and gait (walking) are investigated from 14 healthy untrained subjects, while EMG signals from the muscle group of vastus medialis and the goniometer on the knee joint of the detected leg are synchronously monitored and recorded. Four types of lower-limb motions including standing, sitting, stance phase of walking, and swing phase of walking, are segmented. The Wavelet Transform (WT) based Singular Value Decomposition (SVD) approach is proposed for the classification of four lower-limb motions using a single-channel EMG signal from the muscle group of vastus medialis. Based on lower-limb motions from all subjects, the combination of five-level wavelet decomposition and SVD is used to comprise the feature vector. The Support Vector Machine (SVM) is then configured to build a multiple-subject classifier for which the subject independent accuracy will be given across all subjects for the classification of four types of lower-limb motions. In order to effectively indicate the classification performance, EMG features from time-domain (e.g., Mean Absolute Value (MAV), Root-Mean-Square (RMS), integrated EMG (iEMG), Zero Crossing (ZC)) and frequency-domain (e.g., Mean Frequency (MNF) and Median Frequency (MDF)) are also used to classify lower-limb motions. The five-fold cross validation is performed and it repeats fifty times in order to acquire the robust subject independent accuracy. Results show that the proposed WT-based SVD approach has the classification accuracy of 91.85%±0.88% which

  4. Extracting time-frequency feature of single-channel vastus medialis EMG signals for knee exercise pattern recognition.

    Directory of Open Access Journals (Sweden)

    Yi Zhang

    Full Text Available The EMG signal indicates the electrophysiological response to daily living of activities, particularly to lower-limb knee exercises. Literature reports have shown numerous benefits of the Wavelet analysis in EMG feature extraction for pattern recognition. However, its application to typical knee exercises when using only a single EMG channel is limited. In this study, three types of knee exercises, i.e., flexion of the leg up (standing, hip extension from a sitting position (sitting and gait (walking are investigated from 14 healthy untrained subjects, while EMG signals from the muscle group of vastus medialis and the goniometer on the knee joint of the detected leg are synchronously monitored and recorded. Four types of lower-limb motions including standing, sitting, stance phase of walking, and swing phase of walking, are segmented. The Wavelet Transform (WT based Singular Value Decomposition (SVD approach is proposed for the classification of four lower-limb motions using a single-channel EMG signal from the muscle group of vastus medialis. Based on lower-limb motions from all subjects, the combination of five-level wavelet decomposition and SVD is used to comprise the feature vector. The Support Vector Machine (SVM is then configured to build a multiple-subject classifier for which the subject independent accuracy will be given across all subjects for the classification of four types of lower-limb motions. In order to effectively indicate the classification performance, EMG features from time-domain (e.g., Mean Absolute Value (MAV, Root-Mean-Square (RMS, integrated EMG (iEMG, Zero Crossing (ZC and frequency-domain (e.g., Mean Frequency (MNF and Median Frequency (MDF are also used to classify lower-limb motions. The five-fold cross validation is performed and it repeats fifty times in order to acquire the robust subject independent accuracy. Results show that the proposed WT-based SVD approach has the classification accuracy of 91.85%±0

  5. Turning collectors for solar radiation

    Science.gov (United States)

    Barak, Amitzur Z.

    1976-01-01

    A device is provided for turning a solar collector about the polar axis so that the collector is directed toward the sun as the sun tracks the sky each day. It includes two heat-expansive elements and a shadow plate. In the morning a first expansive element is heated, expands to turn the collector to face the sun, while the second expansive element is shaded by the plate. In the afternoon the second element is heated, expands to turn the collector to face the sun, while the first is shaded by the plate.

  6. Esthetic Assessment of Implants Placed into Fresh Extraction Sockets for Single-Tooth Replacements Using a Flapless Approach.

    Science.gov (United States)

    Kolerman, Roni; Mijiritsky, Eitan; Barnea, Eitan; Dabaja, Areeje; Nissan, Joseph; Tal, Haim

    2017-04-01

    To validate the concept of immediate implant placement and nonfunctional loading for use in the esthetically sensitive anterior maxilla, clinical trials should ideally include objective esthetic criteria. This study analyzed procedural results as graded by the pink esthetic score and white esthetic score (PES/WES). Thirty-nine suitable patients (mean follow-up 44.82 ± 28 months) were evaluated. Thirty-eight implants fulfilled stringent criteria for successful osseointegration: absence of peri-implant radiolucency, implant mobility, suppuration, and pain. The mean total PES/WES was 15.50 ± 2.67 (range: 10-20). The mean total PES of 7.92 ± 1.60 (range: 5-10) indicated favorable overall peri-implant soft-tissue conditions. Root convexity and texture (1.63 ± 0.54) and curvature of the facial mucosa (1.68 ± 0.47) and distal papilla (1.66 ± 0.48) had the highest mean values, whereas acceptable levels of facial tissue (1.53 ± 0.73) and mesial papilla (1.42 ± 0.64) were the most difficult to fully achieve. The mean mesial and distal bone loss at data collection was, was 1.19 ± 0.54 and 1.15 ± 0.51, respectively. Periodontal disease severity (advanced chronic and aggressive periodontitis) was significantly associated with a low total PES (p = .048). Objective PES/WES assessment validated immediate anterior maxillary single-tooth replacement and restoration as being a successful and esthetically predictable treatment modality in sites where the buccal bone had been preserved during the extraction at 1 year of follow-up. © 2016 Wiley Periodicals, Inc.

  7. Extraction of fetal ECG signal by an improved method using extended Kalman smoother framework from single channel abdominal ECG signal.

    Science.gov (United States)

    Panigrahy, D; Sahu, P K

    2017-03-01

    This paper proposes a five-stage based methodology to extract the fetal electrocardiogram (FECG) from the single channel abdominal ECG using differential evolution (DE) algorithm, extended Kalman smoother (EKS) and adaptive neuro fuzzy inference system (ANFIS) framework. The heart rate of the fetus can easily be detected after estimation of the fetal ECG signal. The abdominal ECG signal contains fetal ECG signal, maternal ECG component, and noise. To estimate the fetal ECG signal from the abdominal ECG signal, removal of the noise and the maternal ECG component presented in it is necessary. The pre-processing stage is used to remove the noise from the abdominal ECG signal. The EKS framework is used to estimate the maternal ECG signal from the abdominal ECG signal. The optimized parameters of the maternal ECG components are required to develop the state and measurement equation of the EKS framework. These optimized maternal ECG parameters are selected by the differential evolution algorithm. The relationship between the maternal ECG signal and the available maternal ECG component in the abdominal ECG signal is nonlinear. To estimate the actual maternal ECG component present in the abdominal ECG signal and also to recognize this nonlinear relationship the ANFIS is used. Inputs to the ANFIS framework are the output of EKS and the pre-processed abdominal ECG signal. The fetal ECG signal is computed by subtracting the output of ANFIS from the pre-processed abdominal ECG signal. Non-invasive fetal ECG database and set A of 2013 physionet/computing in cardiology challenge database (PCDB) are used for validation of the proposed methodology. The proposed methodology shows a sensitivity of 94.21%, accuracy of 90.66%, and positive predictive value of 96.05% from the non-invasive fetal ECG database. The proposed methodology also shows a sensitivity of 91.47%, accuracy of 84.89%, and positive predictive value of 92.18% from the set A of PCDB.

  8. SNS Injection and Extraction Devices

    CERN Document Server

    Raparia, Deepak

    2005-01-01

    The Spallation Neutron Source (SNS) is a second generation pulsed neutron source (1.5 MW) and is presently in the sixth year of a seven-year construction cycle at Oak Ridge National Laboratory. The operation of the facility will begin in 2006. The most stringent requirement for the SNS accelerator complex is to allow hands-on maintenance. Operational experiences show that the most losses occur in the injection and extraction. SNS accumulator ring injection and extraction has been design with grate care to reduce uncontrolled losses. Injection systems consist of fast programmable kicker magnets and DC dump magnets to paint the beam in transverse phase space. Extraction systems consist of fast kicker magnets and a Lamberton magnet to extract beam in single turn. Paper will discuss design, construction and testing of these devices.

  9. Multi-staging for extraction of cesium from nitric acid by a single liquid-liquid countercurrent centrifugal extractor with Taylor vortices

    International Nuclear Information System (INIS)

    Nakase, Masahiko; Kinuhata, Hiroshi; Takeshita, Kenji

    2013-01-01

    Fission products that emit considerable decay heat and radioactivity, such as 137 Cs, have a large impact on waste management. Small and high-performance extractor is desirable for separating such nuclei. In this study, we implemented the continuous extraction of Cs from nitric acid in a single liquid-liquid countercurrent centrifugal extractor with Taylor Vortices by calix arene-bis(t-octylbenzo-crown-6)(BOBCalixC6) as an extractant with trioctylamine(TOA) as a suppressant and with 1-(2,2,3,3-tetrafluoropropoxy)-3-(4-sec-butylphenoxy)-2-propanol (Cs-7SB) as a phase modifier. Because of slow extraction kinetics of this process, extraction with multiple theoretical stages by just replacing conventional extractors into the single centrifugal extractor is difficult. Hence, we improved the dispersion of organic phase by an inner rotor made of lipophilic epoxy resin and elevating the solution temperature to lower the viscosity. Higher temperature was not appropriate from the aspect of chemical equilibrium in this process, but extraction with multiple theoretical stages was found to be possible. (author)

  10. Magnetic single-walled carbon nanotubes-dispersive solid-phase extraction method combined with liquid chromatography-tandem mass spectrometry for the determination of paraquat in urine.

    Science.gov (United States)

    Ruan, Xiao-Lin; Qiu, Jing-Jing; Wu, Chuan; Huang, Tao; Meng, Rui-Bo; Lai, Yong-Qiang

    2014-08-15

    In this study, magnetic single-walled carbon nanotubes (MSWCNTs) were prepared by impregnating magnetic Fe3O4 nanoparticles onto the surfaces of carboxylic single-walled carbon nanotubes based on electrostatic interactions. The prepared MSWCNTs were used as the adsorbent for the dispersive solid-phase extraction (DSPE) of paraquat from human urine. After adsorption, the paraquat was quantitatively desorbed with 5%TFA in acetonitrile and determined by HPLC-MS. Extraction parameters such as the type of CNT adsorbent, extraction time, sample volume, wash solvent, and the type and volume of desorption solvent were optimized to obtain high DSPE recoveries and extraction efficiencies. Under the optimized conditions, the calibration curve was linear in the range 3.75-375.0 μg/L with a correlation coefficient of 0.999 45. The LOD (S/N=3) and LOQ (S/N=10) were 0.94 and 2.82 μg/L, respectively. The recoveries ranged from 92.89 to 108.9% for spiked real urine samples with RSDs below 3.21%. Finally, the new method was successfully used to determine paraquat in urine samples of suspected paraquat poisoning patients. The MSWCNTs exhibited suitable properties and a high adsorption capacity for the extraction of paraquat. Copyright © 2014 Elsevier B.V. All rights reserved.

  11. What 'empirical turn in bioethics'?

    Science.gov (United States)

    Hurst, Samia

    2010-10-01

    Uncertainty as to how we should articulate empirical data and normative reasoning seems to underlie most difficulties regarding the 'empirical turn' in bioethics. This article examines three different ways in which we could understand 'empirical turn'. Using real facts in normative reasoning is trivial and would not represent a 'turn'. Becoming an empirical discipline through a shift to the social and neurosciences would be a turn away from normative thinking, which we should not take. Conducting empirical research to inform normative reasoning is the usual meaning given to the term 'empirical turn'. In this sense, however, the turn is incomplete. Bioethics has imported methodological tools from empirical disciplines, but too often it has not imported the standards to which researchers in these disciplines are held. Integrating empirical and normative approaches also represents true added difficulties. Addressing these issues from the standpoint of debates on the fact-value distinction can cloud very real methodological concerns by displacing the debate to a level of abstraction where they need not be apparent. Ideally, empirical research in bioethics should meet standards for empirical and normative validity similar to those used in the source disciplines for these methods, and articulate these aspects clearly and appropriately. More modestly, criteria to ensure that none of these standards are completely left aside would improve the quality of empirical bioethics research and partly clear the air of critiques addressing its theoretical justification, when its rigour in the particularly difficult context of interdisciplinarity is what should be at stake.

  12. Data on a single oral dose of camu camu (Myrciaria dubia pericarp extract on flow-mediated vasodilation and blood pressure in young adult humans

    Directory of Open Access Journals (Sweden)

    Tadayoshi Miyashita

    2018-02-01

    Full Text Available This data article describes the flow-mediated vasodilation (FMD responses, represented by changes in arterial diameter, and blood pressure changes in young adults after a single oral dose of camu camu (Myrciaria dubia pericarp extract or placebo (cross-over design. Ten healthy men and 10 healthy women participated in this study. Ultrasonic diagnostic equipment was used to monitor arterial diameter changes, indicative of FMD, for 110 s after the administration of the camu camu extract or placebo. In addition, the systolic and diastolic blood pressure values were recorded.

  13. A high-throughput RNA extraction for sprouted single-seed malting barley (Hordeum vulgare L.) rich in polysaccharides

    Science.gov (United States)

    Germinated seed from cereal crops including barley (Hordeum vulgare L.) is an important tissue to extract RNA and analyze expression levels of genes that control aspects of germination. These tissues are rich in polysaccharides and most methods for RNA extraction are not suitable to handle the exces...

  14. Development of on-line single-drop micro-extraction sequential injection system for electrothermal atomic absorption spectrometric determination of trace metals

    International Nuclear Information System (INIS)

    Anthemidis, Aristidis N.; Adam, Ibrahim S.I.

    2009-01-01

    A novel automatic sequential injection (SI) single-drop micro-extraction (SDME) system is proposed as versatile approach for on-line metal preconcentration and/or separation. Coupled to electrothermal atomic absorption spectrometry (ETAAS) the potentials of this SI scheme are demonstrated for trace cadmium determination in water samples. A non-charged complex of cadmium with ammonium diethyldithiophosphate (DDPA) was produced and extracted on-line into a 60 μL micro-drop of di-isobutyl ketone (DIBK). The extraction procedure was performed into a newly designed flow-through extraction cell coupled on a sequential injection manifold. As the complex Cd(II)-DDPA flowed continuously around the micro-droplet, the analyte was extracting into the solvent micro-drop. All the critical parameters were optimized and offered good performance characteristics and high preconcentration ratios. For 600 s micro-extraction time, the enhancement factor was 10 and the sampling frequency was 6 h -1 . The detection limit was 0.01 μg L -1 and the precision (RSD at 0.1 μg L -1 of cadmium) was 3.9%. The proposed method was evaluated by analyzing certified reference material

  15. On-Demand Single Photons with High Extraction Efficiency and Near-Unity Indistinguishability from a Resonantly Driven Quantum Dot in a Micropillar

    DEFF Research Database (Denmark)

    Ding, Xing; He, Yu; Duan, Z.-C.

    2016-01-01

    Scalable photonic quantum technologies require on-demand single-photon sources with simultaneously high levels of purity, indistinguishability, and efficiency. These key features, however, have only been demonstrated separately in previous experiments. Here, by s-shell pulsed resonant excitation...... of a Purcellenhanced quantum dot-micropillar system, we deterministically generate resonance fluorescence single photons which, at π pulse excitation, have an extraction efficiency of 66%, single-photon purity of 99.1%, and photon indistinguishability of 98.5%. Such a single-photon source for the first time combines...... the features of high efficiency and near-perfect levels of purity and indistinguishabilty, and thus opens the way to multiphoton experiments with semiconductor quantum dots....

  16. Using discrete-time mathematical programming to optimise the extraction rate of a durable non-renewable resource with a single primary supplier

    Directory of Open Access Journals (Sweden)

    Albert Corominas

    Full Text Available A non-linear discrete-time mathematical program model is proposed to determining the optimal extraction policy for a single primary supplier of a durable non-renewable resource, such as gemstones or some metals. Karush, Kuhn and Tucker conditions allow obtaining analytic solutions and general properties of them in some specific settings. Moreover, provided that the objective function (i.e., the discounted value of the incomes throughout the planning horizon is concave, the model can be easily solved, even using standard commercial solver. However, the analysis of the solutions obtained for different assumptions of the values of the parameters show that the optimal extraction policies and the corresponding prices do not exhibit a general shape. Keywords: Durable non-renewable resources, Single primary supplier, Non-linear programming

  17. Turning rice meiosis into mitosis.

    Science.gov (United States)

    Mieulet, Delphine; Jolivet, Sylvie; Rivard, Maud; Cromer, Laurence; Vernet, Aurore; Mayonove, Pauline; Pereira, Lucie; Droc, Gaëtan; Courtois, Brigitte; Guiderdoni, Emmanuel; Mercier, Raphael

    2016-11-01

    Introduction of clonal reproduction through seeds (apomixis) in crops has the potential to revolutionize agriculture by allowing self-propagation of any elite variety, in particular F1 hybrids. In the sexual model plant Arabidopsis thaliana synthetic clonal reproduction through seeds can be artificially implemented by (i) combining three mutations to turn meiosis into mitosis (MiMe) and (ii) crossing the obtained clonal gametes with a line expressing modified CENH3 and whose genome is eliminated in the zygote. Here we show that additional combinations of mutations can turn Arabidopsis meiosis into mitosis and that a combination of three mutations in rice (Oryza sativa) efficiently turns meiosis into mitosis, leading to the production of male and female clonal diploid gametes in this major crop. Successful implementation of the MiMe technology in the phylogenetically distant eudicot Arabidopsis and monocot rice opens doors for its application to any flowering plant and paves the way for introducing apomixis in crop species.

  18. Optimum transfer between hyperbolic asymptotes with turn angle less than the maximum natural turn angle.

    Science.gov (United States)

    Walton, J. M.; Marchal, C.; Culp, R. D.

    1971-01-01

    The impulsive transfer of minimum characteristic velocity between two given hyperbolic asymptotes associated with a real planet is considered. The constraint of remaining above the surface of the planet introduces a maximum natural turn angle. This divides the problem naively into two categories. The first is the case when the turn angle required by the given asymptotes is less than or equal to the maximum natural turn angle. This is the more reasonable situation for a swingby maneuver, and is the case considered in this paper. The resulting optimal transfers are of five basic types. In boundary conditions space, by far the largest area of transfers are either single impulse transfers or transfers through the parabolic level requiring two finite impulses. In no case has an optimal transfer been found which uses more than two finite impulses and three infinitesimal impulses. Complete results are presented for the case in which the given turn angle is less than or equal to the maximum natural turn angle.

  19. Absence of QTc-interval-prolonging or hemodynamic effects of a single dose of bitter-orange extract in healthy subjects.

    Science.gov (United States)

    Min, Bokyung; Cios, Deborah; Kluger, Jeffrey; White, C Michael

    2005-12-01

    To evaluate the hemodynamic and electrocardiographic effects of a single dose of commercially available bitter-orange dried-fruit extract, which is increasingly being used in dietary supplements. Randomized, double-blind, placebo-controlled, crossover study. University of Connecticut, Storrs Campus. Eighteen healthy volunteers aged 18 years or older. Subjects were given either placebo or bitter-orange dried-fruit extract (450 mg standardized to 27 mg of m- or p-synephrine) in phase 1. The opposite treatment was given during phase 2 after a washout period of at least 7 days. The rate-corrected QT (QTc) interval and blood pressure were measured before dosing and at 1, 3, 5, and 8 hours after dosing. Mean+/-SD values of the maximum postdose values were compared between groups. Subjects receiving bitter-orange extract versus those receiving placebo had similar postdose QTc intervals (402+/-29 vs 403+/-24 msec, p=0.653), systolic blood pressure (114+/-10 vs 115+/-8 mm Hg, p=0.686) and diastolic blood pressure (68+/-9 vs 68+/-8, p=0.879). Bitter-orange dried-fruit extract standardized to m- or p-synephrine 27 mg did not significantly alter the QTc interval or blood pressure after a single dose was administered. Future studies are necessary to ensure the safety of this herbal product with multiple doses.

  20. The AGS accelerator complex with the new fast extraction system

    International Nuclear Information System (INIS)

    Tanaka, M.; Bleser, E.J.; Glenn, J.W.; Lee, Y.Y.; Soukas, A.

    1995-01-01

    The delivery of a beam with characteristics appropriate for the g-2 muon storage ring and the filling of the RHIC heavy ion collider from the AGS main ring requires a new fast extracted beam (FEB) system. The new FEB system will be capable of performing both one-turn fast extraction and single bunch multiple extraction of either a heavy ion beam or a high intensity proton beam at a rate of 30 Hz up to 12 times per AGS cycle. The new system consists of a fast multi-pulsing kicker and an ejector septum magnet with local extraction orbit bumps

  1. Single- and two-phase flow simulation based on equivalent pore network extracted from micro-CT images of sandstone core.

    Science.gov (United States)

    Song, Rui; Liu, Jianjun; Cui, Mengmeng

    2016-01-01

    Due to the intricate structure of porous rocks, relationships between porosity or saturation and petrophysical transport properties classically used for reservoir evaluation and recovery strategies are either very complex or nonexistent. Thus, the pore network model extracted from the natural porous media is emphasized as a breakthrough to predict the fluid transport properties in the complex micro pore structure. This paper presents a modified method of extracting the equivalent pore network model from the three-dimensional micro computed tomography images based on the maximum ball algorithm. The partition of pore and throat are improved to avoid tremendous memory usage when extracting the equivalent pore network model. The porosity calculated by the extracted pore network model agrees well with the original sandstone sample. Instead of the Poiseuille's law used in the original work, the Lattice-Boltzmann method is employed to simulate the single- and two- phase flow in the extracted pore network. Good agreements are acquired on relative permeability saturation curves of the simulation against the experiment results.

  2. Efficacy of a single dose of low-level laser therapy in reducing pain, swelling, and trismus following third molar extraction surgery.

    Science.gov (United States)

    Landucci, A; Wosny, A C; Uetanabaro, L C; Moro, A; Araujo, M R

    2016-03-01

    The clinical efficacy of low-level laser therapy (LLLT) for the reduction of pain, swelling, and trismus following the surgical extraction of third molars was evaluated. Mandibular third molars, with similar radiographic positions on two distinct sections, were extracted from 22 patients. Immediately after extraction from the randomly selected right or left side, LLLT was applied (study group). The same extraction procedure was performed 21 days later on the other third molar, without the application of LLLT (control group). LLLT was applied at 10 points: four intraoral in close proximity to the socket and six extraoral along the masseter muscle. Pain intensity was assessed using a visual analogue scale, swelling was measured as the distance from the tragus to the median base of the mentum, and trismus was assessed by the extent of mouth opening. Data were collected at four time points: before surgery, immediately after surgery, 48h postoperatively, and 7 days postoperatively. Compared with the control group, the study group showed significant reductions in pain, swelling, and trismus at 48h and 7 days postoperatively. In conclusion, a single dose of LLLT was effective at reducing the postoperative discomforts (pain, swelling, and trismus) associated with third molar extraction surgery. Copyright © 2015 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

  3. Professional Employees Turn to Unions

    Science.gov (United States)

    Chamot, Dennis

    1976-01-01

    White-collar and professional employees are increasingly turning to unions to combat their loss of independence as employees of large organizations. Managers should realize that they and professional employees have different viewpoints about job situations and that the current trend toward white-collar unionism is apt to continue. (JG)

  4. Hamilton's theory of turns revisited

    Indian Academy of Sciences (India)

    We present a new approach to Hamilton's theory of turns for the groups. SO(3) and SU(2) which renders their properties, in particular their composition law, nearly trivial and immediately evident upon inspection. We show that the entire con- struction can be based on binary rotations rather than mirror reflections. Keywords.

  5. The Philosophy of Turning Points

    DEFF Research Database (Denmark)

    Turcan, Romeo V.

    2013-01-01

    This paper introduces and discusses the concept of turning points from the ontological, epistemological, and methodological perspectives, applying it to the de-internationalization phenomenon to exemplify its deployment. As a concept that adds to the variance and complexity of the international b...

  6. Why Does Hair Turn Gray?

    Science.gov (United States)

    ... out, but people with naturally lighter hair are just as likely to go gray. From the time a person notices a few gray hairs, it may take more than 10 years for all of that person's hair to turn ... really believe that this happens. Just in case, try not to freak out your ...

  7. Phenomenology and the Empirical Turn

    NARCIS (Netherlands)

    Zwier, Jochem; Blok, Vincent; Lemmens, Pieter

    2016-01-01

    This paper provides a phenomenological analysis of postphenomenological philosophy of technology. While acknowledging that the results of its analyses are to be recognized as original, insightful, and valuable, we will argue that in its execution of the empirical turn, postphenomenology forfeits

  8. Hamilton's theory of turns revisited

    Indian Academy of Sciences (India)

    MS received 16 July 2009; accepted 1 September 2009. Abstract. We present a new approach to Hamilton's theory of turns for the groups. SO(3) and SU(2) which renders their properties, in particular their composition law, nearly trivial and immediately evident upon inspection. We show that the entire con- struction can be ...

  9. High-Quality and -Quantity DNA Extraction from Frozen Archival Blood Clots for Genotyping of Single-Nucleotide Polymorphisms

    DEFF Research Database (Denmark)

    Bank, Steffen; Nexø, Bjørn Andersen; Andersen, Vibeke

    2013-01-01

    Background: The recovery of biological samples for genetic epidemiological studies can be cumbersome. Blood clots are routinely collected for serological examinations. However, the extraction of DNA from blood clots can be difficult and often results in low yields. Aim: The aim was to compare the...

  10. Designed optimization of a single-step extraction of fucose-containing sulfated polysaccharides from Sargassum sp

    DEFF Research Database (Denmark)

    Ale, Marcel Tutor; Mikkelsen, Jørn Dalgaard; Meyer, Anne S.

    2012-01-01

    Fucose-containing sulfated polysaccharides can be extracted from the brown seaweed, Sargassum sp. It has been reported that fucose-rich sulfated polysaccharides from brown seaweeds exert different beneficial biological activities including anti-inflammatory, anticoagulant, and anti-viral effects....

  11. Shadow Analysis Technique for Extraction of Building Height using High Resolution Satellite Single Image and Accuracy Assessment

    Science.gov (United States)

    Raju, P. L. N.; Chaudhary, H.; Jha, A. K.

    2014-11-01

    These High resolution satellite data with metadata information is used to extract the height of the building using shadow. Proposed approach divides into two phases 1) rooftop and shadow extraction and 2) height estimation. Firstly the rooftop and shadow region were extracted by manual/ automatic methods using Example - Based and Rule - Based approaches. After feature extraction next step is estimating height of the building by taking rooftop in association with shadow using Ratio Method and by using the relation between sun-satellite geometry. The performance analysis shows the total mean error of height is 0.67 m from ratio method, 1.51 m from Example - Based Approach and 0.96 m from Rule - Based Approach. Analysis concluded that Ratio Method i.e. manual method is best for height estimation but it is time consuming so the automatic Rule Based approach is best for height estimation in comparison to Example Based Approach because it require more knowledge and selection of more training samples as well as slows the processing rate of the method.

  12. Opposed turns at signalized intersections

    Energy Technology Data Exchange (ETDEWEB)

    Akcelik, R.

    1989-06-01

    The 1985 Highway Capacity Manual (HCM) brought the U.S. and Australian methodologies for signalized intersections closer together. An important element in this methodology is the techniques used for the estimation of opposed (permissive) turn saturation flows. Although the basic modeling philosophies of the HCM and Australian methods are similar, there are significant differences in the procedures used and therefore in the results from the two methods. In particular, the latest methodology employed in the SIDRA software has eliminated the use of opposed turn adjustment factors for lane groups and adopted an explicit and direct method of modeling individual lanes. The purpose of this paper is to bring these new methods to the attention of the U.S. researchers since it is understood that efforts are being made to improve the 1985 HCM method.

  13. Diamond turning machine controller implementation

    Energy Technology Data Exchange (ETDEWEB)

    Garrard, K.P.; Taylor, L.W.; Knight, B.F.; Fornaro, R.J.

    1988-12-01

    The standard controller for a Pnuemo ASG 2500 Diamond Turning Machine, an Allen Bradley 8200, has been replaced with a custom high-performance design. This controller consists of four major components. Axis position feedback information is provided by a Zygo Axiom 2/20 laser interferometer with 0.1 micro-inch resolution. Hardware interface logic couples the computers digital and analog I/O channels to the diamond turning machine`s analog motor controllers, the laser interferometer, and other machine status and control information. It also provides front panel switches for operator override of the computer controller and implement the emergency stop sequence. The remaining two components, the control computer hardware and software, are discussed in detail below.

  14. In-situ determination of metallic variation and multi-association in single particles by combining synchrotron microprobe, sequential chemical extraction and multivariate statistical analysis.

    Science.gov (United States)

    Zhu, Yu-Min; Zhang, Hua; Fan, Shi-Suo; Wang, Si-Jia; Xia, Yi; Shao, Li-Ming; He, Pin-Jing

    2014-07-15

    Due to the heterogeneity of metal distribution, it is challenging to identify the speciation, source and fate of metals in solid samples at micro scales. To overcome these challenges single particles of air pollution control residues were detected in situ by synchrotron microprobe after each step of chemical extraction and analyzed by multivariate statistical analysis. Results showed that Pb, Cu and Zn co-existed as acid soluble fractions during chemical extraction, regardless of their individual distribution as chlorides or oxides in the raw particles. Besides the forms of Fe2O3, MnO2 and FeCr2O4, Fe, Mn, Cr and Ni were closely associated with each other, mainly as reducible fractions. In addition, the two groups of metals had interrelations with the Si-containing insoluble matrix. The binding could not be directly detected by micro-X-ray diffraction (μ-XRD) and XRD, suggesting their partial existence as amorphous forms or in the solid solution. The combined method on single particles can effectively determine metallic multi-associations and various extraction behaviors that could not be identified by XRD, μ-XRD or X-ray absorption spectroscopy. The results are useful for further source identification and migration tracing of heavy metals. Copyright © 2014 Elsevier B.V. All rights reserved.

  15. Ultrasonic nebulization extraction-heating gas flow transfer-headspace single drop microextraction of essential oil from pericarp of Zanthoxylum bungeanum Maxim.

    Science.gov (United States)

    Wei, Shigang; Zhang, Huihui; Wang, Yeqiang; Wang, Lu; Li, Xueyuan; Wang, Yinghua; Zhang, Hanqi; Xu, Xu; Shi, Yuhua

    2011-07-22

    The ultrasonic nebulization extraction-heating gas flow transfer coupled with headspace single drop microextraction (UNE-HGFT-HS-SDME) was developed for the extraction of essential oil from Zanthoxylum bungeanum Maxim. The gas chromatography-mass spectrometry was applied to the determination of the constituents in the essential oil. The contents of the constituents from essential oil obtained by the proposed method were found to be more similar to those obtained by hydro-distillation (HD) than those obtained by ultrasonic nebulization extraction coupled with headspace single drop microextraction (UNE-HS-SDME). The heating gas flow was firstly used in the analysis of the essential oil to transfer the analytes from the headspace to the solvent microdrop. The relative standard deviations for determining the five major constituents were in the range from 1.5 to 6.7%. The proposed method is a fast, sensitive, low cost and small sample consumption method for the determination of the volatile and semivolatile constituents in the plant materials. Copyright © 2011 Elsevier B.V. All rights reserved.

  16. Turning points in reactor design

    Energy Technology Data Exchange (ETDEWEB)

    Beckjord, E.S.

    1995-09-01

    This article provides some historical aspects on nuclear reactor design, beginning with PWR development for Naval Propulsion and the first commercial application at Yankee Rowe. Five turning points in reactor design and some safety problems associated with them are reviewed: (1) stability of Dresden-1, (2) ECCS, (3) PRA, (4) TMI-2, and (5) advanced passive LWR designs. While the emphasis is on the thermal-hydraulic aspects, the discussion is also about reactor systems.

  17. Turning points in reactor design

    International Nuclear Information System (INIS)

    Beckjord, E.S.

    1995-01-01

    This article provides some historical aspects on nuclear reactor design, beginning with PWR development for Naval Propulsion and the first commercial application at Yankee Rowe. Five turning points in reactor design and some safety problems associated with them are reviewed: (1) stability of Dresden-1, (2) ECCS, (3) PRA, (4) TMI-2, and (5) advanced passive LWR designs. While the emphasis is on the thermal-hydraulic aspects, the discussion is also about reactor systems

  18. Preconcentration of thallium (I) by single drop microextraction with electrothermal atomic absorption spectroscopy detection using dicyclohexano-18-crown-6 as extractant system

    International Nuclear Information System (INIS)

    Chamsaz, Mahmoud; Arbab-Zavar, Mohammad Hossien; Darroudi, Abolfazl; Salehi, Thiery

    2009-01-01

    A simple single drop liquid-phase microextraction (SDME) technique, combined with electrothermal atomic absorption spectroscopy (ETAAS) is developed both to preconcentrate and determine thallium (I) ions in aqueous solutions. The ions were transferred from 10.0 ml of aqueous sample (donor phase) containing 0.5 ml of 1% picric acid as the ion-pair agent into a 3 μl microdrop of nitrobenzene (acceptor phase) containing dicyclohexano-18-crown-6 as the complexing agent. The latter will help to improve the extraction efficiency of the analyte. After the ions have been extracted, the acceptor drop was directly injected into a graphite furnace for thallium (I) determination. Several parameters such as the extracting solvent, extraction time, temperature, concentration of picric acid and crown ether, drop volume and stirring rate were examined. Under the optimized experimental conditions, the detection limit (L.O.D.) was 0.7 ng ml -1 . The relative standard deviation for five replicate analysis of 10 ng ml -1 of thallium (I) was 5.1%. The calibration curve was linear in the range of 3-22 ng ml -1 . The results for determination of thallium in reference material, spiked tap water and seawater demonstrated the accuracy, recovery and applicability of the presented method. The enrichment factor was 50.

  19. Preconcentration of thallium (I) by single drop microextraction with electrothermal atomic absorption spectroscopy detection using dicyclohexano-18-crown-6 as extractant system.

    Science.gov (United States)

    Chamsaz, Mahmoud; Arbab-Zavar, Mohammad Hossien; Darroudi, Abolfazl; Salehi, Thiery

    2009-08-15

    A simple single drop liquid-phase microextraction (SDME) technique, combined with electrothermal atomic absorption spectroscopy (ETAAS) is developed both to preconcentrate and determine thallium (I) ions in aqueous solutions. The ions were transferred from 10.0 ml of aqueous sample (donor phase) containing 0.5 ml of 1% picric acid as the ion-pair agent into a 3 microl microdrop of nitrobenzene (acceptor phase) containing dicyclohexano-18-crown-6 as the complexing agent. The latter will help to improve the extraction efficiency of the analyte. After the ions have been extracted, the acceptor drop was directly injected into a graphite furnace for thallium (I) determination. Several parameters such as the extracting solvent, extraction time, temperature, concentration of picric acid and crown ether, drop volume and stirring rate were examined. Under the optimized experimental conditions, the detection limit (L.O.D.) was 0.7 ng ml(-1). The relative standard deviation for five replicate analysis of 10 ng ml(-1) of thallium (I) was 5.1%. The calibration curve was linear in the range of 3-22 ng ml(-1). The results for determination of thallium in reference material, spiked tap water and seawater demonstrated the accuracy, recovery and applicability of the presented method. The enrichment factor was 50.

  20. Study on a Single-Dose Toxicity Test of D-Amino Acid Oxidase (DAAO Extracts Injected into the Tail Vein of Rats

    Directory of Open Access Journals (Sweden)

    Kang Jungue

    2013-06-01

    Full Text Available Objective: This study was performed to analyze the single-dose toxicity of D-amino acid oxidase (DAAO extracts. Methods: All experiments were conducted at the Korea Testing & Research Institute (KTR, an institution authorized to perform non-clinical studies, under the regulations of Good Laboratory Practice (GLP. Sprague-Dawley rats were chosen for the pilot study. Doses of DAAO extracts, 0.1 to 0.3 cc, were administered to the experimental group, and the same doses of normal saline solution were administered to the control group. This study was conducted under the approval of the Institutional Animal Ethics Committee. Results: In all 4 groups, no deaths occurred, and the LD50 of DAAO extracts administered by IV was over 0.3 ml/kg. No significant changes in the weight between the control group and the experimental group were observed. To check for abnormalities in organs and tissues, we used microscopy to examine representative histological sections of each specified organ, the results showed no significant differences in any organs or tissues. Conclusion: The above findings suggest that treatment with D-amino acid oxidase extracts is relatively safe. Further studies on this subject should be conducted to yield more concrete evidence.

  1. Turn-by-Turn Imaging of the Transverse Beam Profile in PEP-II

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, Alan A.; Petree, Mark; /SLAC

    2006-12-18

    During injection or instability, the transverse profile of an individual bunch in a storage ring can change significantly in a few turns. However, most synchrotron-light imaging techniques are not designed for this time scale. We have developed a novel diagnostic that enhances the utility of a fast gated camera by adding, inexpensively, some features of a dual-axis streak camera, in order to watch the turn-by-turn evolution of the transverse profile, in both x and y. The beam's elliptical profile is reshaped using cylindrical lenses to form a tall and narrow ellipse--essentially the projection of the full ellipse onto one transverse axis. We do this projection twice, by splitting the beam into two paths at different heights, and rotating the ellipse by 90{sup o} on one path. A rapidly rotating mirror scans these vertical ''pencils'' of light horizontally across the photocathode of the camera, which is gated for 3 ns on every Nth ring turn. A single readout of the camera captures 100 images, looking like a stroboscopic photograph of a moving object. We have observed the capture of injected charge into a bunch and the rapid change of beam size at the onset of a fast instability.

  2. Development of a method to extract and purify target compounds from medicinal plants in a single step: online hyphenation of expanded bed adsorption chromatography and countercurrent chromatography

    Science.gov (United States)

    Li, Yang; Wang, Nan; Zhang, Min; Ito, Yoichiro; Zhang, Hongyang; Wang, Yuerong; Guo, Xin; Hu, Ping

    2014-01-01

    Pure compounds extracted and purified from natural sources are crucial to lead discovery and drug screening. This study presents a novel two-dimensional hyphenation of expanded bed adsorption chromatography (EBAC) and high-speed countercurrent chromatography (HSCCC) for extraction and purification of target compounds from medicinal plants in a single step. The EBAC and HSCCC were hyphenated via a six-port injection valve as an interface. Fractionation of ingredients of Salvia miltiorrhiza and Rhizoma coptidis was performed on the hyphenated system to verify its efficacy. An amount each of 52.9 mg of salvianolic acid B and 2.1 mg of rosmarinic acid was obtained from Salvia miltiorrhiza by the two-dimensional system in a single step. The purities of the targets were over 96% of salvianolic acid B and 74% of rosmarinic acid. An amount each of 4.6 mg of coptisine and 4.1 mg of berberine was obtained from Rhizoma coptidis each with 98% and 82% purity, respectively. The processing time was nearly 50% that of the multi-step method. These results indicate that the present method is a rapid and green way to harvest targets from medicinal plants in a single step. PMID:24588208

  3. The diuretic effect in human subjects of an extract of Taraxacum officinale folium over a single day.

    Science.gov (United States)

    Clare, Bevin A; Conroy, Richard S; Spelman, Kevin

    2009-08-01

    Taraxacum officinale (L.) Weber (Asteraceae) has been extensively employed as a diuretic in traditional folk medicine and in modern phytotherapy in Europe, Asia, and the Americas without prior clinical trial substantiation. In this pilot study, a high-quality fresh leaf hydroethanolic extract of the medicinal plant T. officinale (dandelion) was ingested by volunteers to investigate whether an increased urinary frequency and volume would result. Volume of urinary output and fluid intake were recorded by subjects. Baseline values for urinary frequency and excretion ratio (urination volume:fluid intake) were established 2 days prior to dandelion dosing (8 mL TID) and monitored throughout a 1-day dosing period and 24 hours postdosing. For the entire population (n = 17) there was a significant (p officinale ethanolic extract shows promise as a diuretic in humans. Further studies are needed to establish the value of this herb for induction of diuresis in human subjects.

  4. Extraction of contact resistance and channel parameters from the electrical characteristics of a single bottom-gate/top-contact organic transistor

    Science.gov (United States)

    Takagaki, Shunsuke; Yamada, Hirofumi; Noda, Kei

    2016-03-01

    A parameter extraction procedure for staggered-type organic field-effect transistors (OFETs), in which only the electrical characteristics of a single device are needed, was newly considered. The existing differential method and the transition voltage method for evaluating contact and channel parameters in OFETs were complementarily combined. The calibration of the total resistance between the source and the drain was also incorporated to compensate discrepancies in the total resistances calculated from output and transfer characteristics, caused by the existence of nonignorable contact resistance and carrier traps. By using our proposed method, gate-voltage-dependent contact resistance and channel mobility in the linear regime were evaluated for bottom-gate/top-contact pentacene thin-film transistors, and the channel-length dependence of these parameters was investigated. A series of results of parameter extraction confirm the validity of our proposed method, which is advantageous in avoiding the influences of characteristic variations that are frequently observed in practical OFET devices.

  5. Determination of catechins and caffeine in camillia sinensis raw materials, extracts, and dietary supplements by HPLC-uv: single-laboratory validation.

    Science.gov (United States)

    Roman, Mark C

    2013-01-01

    A rapid method has been developed to quantify seven catechins and caffeine in green tea (Camillia sinensis) raw material and powdered extract, and dietary supplements containing green tea extract. The method utilizes RP HPLC with a phenyl-based stationary phase and gradient elution. Detection is by UV absorbance. The total run time, including column re-equilibration, is 13 min. Single-laboratory validation (SLV) has been performed on the method to determine the repeatability, accuracy, selectivity, LOD, LOQ, ruggedness, and linearity for (+)-catechin, (-)-epicatechin, (-)-epicatechin gallate, (-)-epigallocatechin, (-)-gallocatechin gallate, (-)-epigallocatechin gallate, and (+)-gallocatechin, as well as caffeine. Repeatability precision and recovery results met AOAC guidelines for SLV studies for all catechins and caffeine down to a level of approximately 20 mg/g. Finished products containing high concentrations of minerals require the use of EDTA to prevent decomposition of the catechins.

  6. Surgical extraction of impacted teeth in elderly patients. A retrospective analysis of perioperative complications - the experience of a single institution.

    Science.gov (United States)

    Trybek, Grzegorz; Chruściel-Nogalska, Małgorzata; Machnio, Małgorzata; Smektała, Tomasz; Malinowski, Jerzy; Tutak, Marcin; Sporniak-Tutak, Katarzyna

    2016-09-01

    The aim of this retrospective study was to investigate the most frequent complications and assess their overall rate associated with the surgical extraction of impacted teeth in an elderly patient population. Oral health needs of the elders are often associated with surgical procedures for the creation of appropriate conditions for any further prosthetic treatment. One such process is the removal of severely decayed, fractured or impacted teeth detrimental to the fit or appearance of dentures. While broken and decayed teeth leave little doubt for their removal, impacted teeth divide opinion, some extreme regarding their prophylactic removal and the appropriate age for the procedure. Material was selected from the archives of an Out-Patient Dental Surgery Clinic of the Regional Centre of Dentistry in Szczecin, from 2002 to 2013. The database was independently screened by two investigators according to inclusion and exclusion criteria. After selection process, all included records were screened using a data extraction form to obtain the necessary data. The total number of impacted teeth was 73, of which 29% were partially impacted. The overall complication rate was 24.6%. The most common complications were as follows: haematoma, nerve disturbances and local infections. Surgical extraction in patients above 60 years of age is fraught with a high risk of possible complications. © 2015 John Wiley & Sons A/S and The Gerodontology Association. Published by John Wiley & Sons Ltd.

  7. The affective turn in ethnomusicology

    Directory of Open Access Journals (Sweden)

    Hofman Ana

    2015-01-01

    Full Text Available The affective turn, which has already questioned dominant paradigms in many disciplinary fields including cultural studies, philosophy, political theory, anthropology, psychology and neuroscience, has started to attract more attention in the field of ethnomusicology, becoming a particularly vibrant stream of thought. Drawing on the voices that call for the historicisation of and critical deliberation on the field of affect studies, the article strives to show how theories of affect might expand dominant paradigms in ethnomusicology and also points to their limitations.

  8. Model-independent analysis of the Fermilab Tevatron turn-by-turn beam position monitor measurements

    Energy Technology Data Exchange (ETDEWEB)

    Petrenko, A.V.; /Novosibirsk, IYF; Valishev, A.A.; Lebedev, V.A.; /Fermilab

    2011-09-01

    Coherent transverse beam oscillations in the Tevatron were analyzed with the model-independent analysis (MIA) technique. This allowed one to obtain the model-independent values of coupled betatron amplitudes, phase advances, and dispersion function around the ring from a single dipole kick measurement. In order to solve the MIA mode mixing problem which limits the accuracy of determination of the optical functions, we have developed a new technique of rotational MIA mode untangling. The basic idea is to treat each beam position monitor (BPM) as two BPMs separated in a ring by exactly one turn. This leads to a simple criterion of MIA mode separation: the betatron phase advance between any BPM and its counterpart shifted by one turn should be equal to the betatron tune and therefore should not depend on the BPM position in the ring. Furthermore, we describe a MIA-based technique to locate vibrating magnets in a storage ring.

  9. A 5-year comparison of marginal bone level following immediate loading of single-tooth implants placed in healed alveolar ridges and extraction sockets in the maxilla

    Science.gov (United States)

    Berberi, Antoine N.; Sabbagh, Joseph M.; Aboushelib, Moustafa N.; Noujeim, Ziad F.; Salameh, Ziad A.

    2014-01-01

    Purpose: The aim of present investigation was to evaluate marginal bone level after 5-year follow-up of implants placed in healed ridges and fresh extraction sockets in maxilla with immediate loading protocol. Materials and Methods: Thirty-six patients in need of a single-tooth replacement in the anterior maxilla received 42 Astra Tech implants (Astra Tech Implant system™, Dentsply Implants, Mölndal, Sweden). Implants were placed either in healed ridges (group I) or immediately into fresh extraction sockets (group II). Implants were restored and placed into functional loading immediately by using a prefabricated abutment. Marginal bone level relative to the implant reference point was recorded at implant placement, crown cementation, 12, 36, and 60 months following loading using intra-oral radiographs. Measurements were made on the mesial and distal sides of each implant. Results: Overall, two implants were lost from the group II, before final crown cementation: they were excluded from the study. The mean change in marginal bone loss (MBL) after implant placement was 0.26 ± 0.161 mm for 1 year, and 0.26 ± 0.171 mm for 3 years, and 0.21 ± 0.185 mm for 5 years in extraction sockets and was 0.26 ± 0.176 mm for 1 year and 0.21 ± 0.175 mm for 3 years, and 0.19 ± 0.172 mm for 5 years in healed ridges group. Significant reduction of marginal bone was more pronounced in implants inserted in healed ridges (P implant after cementation of the provisional (P immediately loaded implants placed either in extraction sockets or healed ridges were similar. Functional loading technique by using prefabricated abutment placed during the surgery time seems to maintain marginal bone around implant in both healed and fresh extraction sites. PMID:24550840

  10. A 5-year comparison of marginal bone level following immediate loading of single-tooth implants placed in healed alveolar ridges and extraction sockets in the maxilla.

    Science.gov (United States)

    Berberi, Antoine N; Sabbagh, Joseph M; Aboushelib, Moustafa N; Noujeim, Ziad F; Salameh, Ziad A

    2014-01-01

    The aim of present investigation was to evaluate marginal bone level after 5-year follow-up of implants placed in healed ridges and fresh extraction sockets in maxilla with immediate loading protocol. Thirty-six patients in need of a single-tooth replacement in the anterior maxilla received 42 Astra Tech implants (Astra Tech Implant system™, Dentsply Implants, Mölndal, Sweden). Implants were placed either in healed ridges (group I) or immediately into fresh extraction sockets (group II). Implants were restored and placed into functional loading immediately by using a prefabricated abutment. Marginal bone level relative to the implant reference point was recorded at implant placement, crown cementation, 12, 36, and 60 months following loading using intra-oral radiographs. Measurements were made on the mesial and distal sides of each implant. Overall, two implants were lost from the group II, before final crown cementation: they were excluded from the study. The mean change in marginal bone loss (MBL) after implant placement was 0.26 ± 0.161 mm for 1 year, and 0.26 ± 0.171 mm for 3 years, and 0.21 ± 0.185 mm for 5 years in extraction sockets and was 0.26 ± 0.176 mm for 1 year and 0.21 ± 0.175 mm for 3 years, and 0.19 ± 0.172 mm for 5 years in healed ridges group. Significant reduction of marginal bone was more pronounced in implants inserted in healed ridges (P implant after cementation of the provisional (P immediately loaded implants placed either in extraction sockets or healed ridges were similar. Functional loading technique by using prefabricated abutment placed during the surgery time seems to maintain marginal bone around implant in both healed and fresh extraction sites.

  11. Assessment of bioavailable metals in the sediments of Yamuna flood plain using two different single extraction procedures

    Directory of Open Access Journals (Sweden)

    Sudesh Chaudhary

    2016-01-01

    Full Text Available Though flood plains are considered as most fertile areas across the world but they have come under severe stress due to the flow of untreated domestic and industrial effluents and therefore, needed attention for its characterisation and subsequent treatment plans. The sediment samples, collected at 0–15, 15–35 and 30–60 cm depth levels during pre and post monsoon season from east and west sides of the river Yamuna around the national capital region of Delhi, were assessed for bioavailability of lead (Pb, zinc (Zn and nickel (Ni using Ethylene Diamine Tetra Acetic Acid (EDTA and acetic acid. The average concentrations of Zn (25 ± 6 mg kg−1 and Pb (33 ± 6 mg kg−1 leached in EDTA were higher than that of in acetic acid (Zn: 22 ± 6 mg kg−1; Pb: 24 ± 5 mg kg−1 whereas Ni (24 ± 6 mg kg−1 leached more in acetic acid compared to EDTA (Ni: 21 ± 4 mg kg−1. The bioavailable concentrations of metals were comparable among 0–15 and 15–35 cm depth samples but decreased in 35–60 cm depth samples. The post monsoon samples contained lower amounts of total metals in comparison to pre-monsoon samples, an indication of washout/dilution effects of flood/high water flow during monsoon season. The percentages of metals, with reference to their respective total concentrations, in the flood plain sediments as extracted by EDTA were in the range of 14–47% for Pb, 17–54% for Zn, and 15–39% for Ni. The Zn, Ni and Pb were soluble in acetic acid in the range of 12–39%, 16.7–36.5% and 14–36%, respectively. The chemical nature of extracting agent affected the metal leaching. Acetic acid, a weak acid, extracted the metals that were present in exchangeable fraction and easily movable whereas EDTA, hexa-dentate complexing agent, extracted metals from carbonate and organically bound fractions of the sediment samples. This could result in metal accumulation in the floodplains, biomagnification, adverse

  12. High performance aptamer affinity chromatography for single-step selective extraction and screening of basic protein lysozyme.

    Science.gov (United States)

    Han, Bin; Zhao, Chao; Yin, Junfa; Wang, Hailin

    2012-08-15

    A DNA aptamer based high-performance affinity chromatography is developed for selective extraction and screening of a basic protein lysozyme. First, a poly(glycidyl methacrylate-co-ethylene dimethacrylate) monolithic column was synthesized in situ by thermally initiated radical polymerization, and then an anti-lysozyme DNA aptamer was covalently immobilized on the surface of the monolith through a 16-atom spacer arm. The target protein lysozyme but non-target proteins can be trapped by the immobilized anti-lysozyme DNA aptamer. In contrast, lysozyme cannot be trapped by the immobilized oligodeoxynucleotide that does not contain the sequence of the anti-lysozyme DNA aptamer. The study clearly demonstrates the trapping of lysozyme by the immobilized anti-lysozyme DNA aptamer is mainly due to specific recognition rather than simple electrostatic interaction of positively charged protein and the negatively charged DNA. The inter-day precision was determined as 0.8% for migration time and 4.2% for peak area, respectively. By the use of aptamer affinity monolith, a screening strategy is developed to selectively extract lysozyme from chicken egg white, showing the advantages of high efficiency, low cost and ease-of-operation. Copyright © 2012 Elsevier B.V. All rights reserved.

  13. Concept for ELENA Extraction and Beam Transfer Elements

    CERN Document Server

    Borburgh, J; Balhan, B; Barna, D; Bartmann, W; Fowler, T; Pricop, V; Sermeus, L; Vanbavinckhove, G

    2013-01-01

    In 2011 the ELENA decelerator was approved as a CERN project. Initially one extraction was foreseen, which should use a kicker and a magnetic septum which can be recuperated from an earlier installation. Since then a second extraction has been approved and a new solution was studied using only electric fields to extract the beam. This will be achieved by fast pulsing a separator, allowing single-bunch but also a full single-turn extraction from ELENA towards the experiments. The extraction and transfer requirements of ELENA are described, followed by the principal differences between the magnetic and electric field concepts. The design of electrostatic focussing and bending devices for the transfer lines will be presented. Finally the field quality which can be achieved with the separator and the concept of its power supply will be discussed.

  14. Selective Single-Step Separation of a Mixture of Three Metal Ions by a Triphasic Ionic-Liquid-Water-Ionic-Liquid Solvent Extraction System.

    Science.gov (United States)

    Vander Hoogerstraete, Tom; Blockx, Jonas; De Coster, Hendrik; Binnemans, Koen

    2015-08-10

    In a conventional solvent extraction system, metal ions are distributed between two immiscible phases, typically an aqueous and an organic phase. In this paper, the proof-of-principle is given for the distribution of metal ions between three immiscible phases, two ionic liquid phases with an aqueous phase in between them. Three-liquid-phase solvent extraction allows separation of a mixture of three metal ions in a single step, whereas at least two steps are required to separate three metals in the case of two-liquid-phase solvent extraction. In the triphasic system, the lower organic phase is comprised of the ionic liquid betainium- or choline bis(trifluoromethylsulfonyl)imide, whereas the upper organic phase is comprised of the ionic liquid trihexyl(tetradecyl)phosphonium bis(trifluoromethylsulfonyl)imide. The triphasic system was used for the separation of a mixture of tin(II), yttrium(III), and scandium(III) ions. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Recent developments in turning hardened steels - A review

    Science.gov (United States)

    Sivaraman, V.; Prakash, S.

    2017-05-01

    Hard materials ranging from HRC 45 - 68 such as hardened AISI H13, AISI 4340, AISI 52100, D2 STL, D3 STEEL Steel etc., need super hard tool materials to machine. Turning of these hard materials is termed as hard turning. Hard turning makes possible direct machining of the hard materials and also eliminates the lubricant requirement and thus favoring dry machining. Hard turning is a finish turning process and hence conventional grinding is not required. Development of the new advanced super hard tool materials such as ceramic inserts, Cubic Boron Nitride, Polycrystalline Cubic Boron Nitride etc. enabled the turning of these materials. PVD and CVD methods of coating have made easier the production of single and multi layered coated tool inserts. Coatings of TiN, TiAlN, TiC, Al2O3, AlCrN over cemented carbide inserts has lead to the machining of difficult to machine materials. Advancement in the process of hard machining paved way for better surface finish, long tool life, reduced tool wear, cutting force and cutting temperatures. Micro and Nano coated carbide inserts, nanocomposite coated PCBN inserts, micro and nano CBN coated carbide inserts and similar developments have made machining of hardened steels much easier and economical. In this paper, broad literature review on turning of hardened steels including optimizing process parameters, cooling requirements, different tool materials etc., are done.

  16. Models and Algorithms for Tracking Target with Coordinated Turn Motion

    Directory of Open Access Journals (Sweden)

    Xianghui Yuan

    2014-01-01

    Full Text Available Tracking target with coordinated turn (CT motion is highly dependent on the models and algorithms. First, the widely used models are compared in this paper—coordinated turn (CT model with known turn rate, augmented coordinated turn (ACT model with Cartesian velocity, ACT model with polar velocity, CT model using a kinematic constraint, and maneuver centered circular motion model. Then, in the single model tracking framework, the tracking algorithms for the last four models are compared and the suggestions on the choice of models for different practical target tracking problems are given. Finally, in the multiple models (MM framework, the algorithm based on expectation maximization (EM algorithm is derived, including both the batch form and the recursive form. Compared with the widely used interacting multiple model (IMM algorithm, the EM algorithm shows its effectiveness.

  17. The Effects of Transcutaneous and Intraoral Low-Level Laser Therapy After Extraction of Lower Third Molars: A Randomized Single Blind, Placebo Controlled Dual-Center Study.

    Science.gov (United States)

    Kahraman, Sevil Altundag; Cetiner, Sedat; Strauss, Robert A

    2017-08-01

    The surgical removal of impacted third molars is one of the most common procedures performed by oral and maxillofacial surgeons. The purpose of this study is to determine whether either transcutaneous or intraoral low-level laser therapy (LLLT) reduces postoperative pain and assists in the healing of mandibular third molar extraction. This randomized, placebo controlled, single-blind, split-mouth design study was conducted on 60 patients with full bony impacted similar position mandibular third molars bilaterally. The patients were divided into two groups of 30 each: transcutaneous LLLT and intraoral LLLT and the other side of each group treated with nonactive laser (60 teeth). The laser treatment consisted of administering laser energy immediately before and after the extraction procedure with gallium aluminum arsenide (GaAlAs) 830 nm diode lasers. Postoperative pain and healing of the sockets were compared in transcutaneous and intraoral group with placebo for 1 week following the extraction. Descriptive and bivariate statistics was computed, and the p-value was set at 0.05. Intraoral LLLT application resulted in a statistically significant reduction of postoperative pain in comparison with transcutaneous laser group and placebo. The unhealed socket numbers were compared in two groups at seventh day and no differences were observed. The results of this study suggest that single-session intraoral LLLT is more effective than extraoral application for reducing postoperative pain. It was postulated that the differences between skin and mucosa could have effect on the results. Although intraoral use would allow closer application to the surgical site, the size of some laser devices precludes their use intraorally.

  18. Technical reproducibility of single-nucleotide and size-based DNA biomarker assessment using DNA extracted from formalin-fixed, paraffin-embedded tissues.

    Science.gov (United States)

    Zhang, Shenli; Tan, Iain B; Sapari, Nur S; Grabsch, Heike I; Okines, Alicia; Smyth, Elizabeth C; Aoyama, Toru; Hewitt, Lindsay C; Inam, Imran; Bottomley, Dan; Nankivell, Matthew; Stenning, Sally P; Cunningham, David; Wotherspoon, Andrew; Tsuburaya, Akira; Yoshikawa, Takaki; Soong, Richie; Tan, Patrick

    2015-05-01

    DNA extracted from formalin-fixed, paraffin-embedded (FFPE) tissues has been used in the past to analyze genetic polymorphisms. We evaluated the technical reproducibility of different types of assays for gene polymorphisms using DNA extracted from FFPE material. By using the MassARRAY iPLEX system, we investigated polymorphisms in DPYD (rs1801159 and rs3918290), UMPS (rs1801019), ERCC1 (rs11615), ERCC1 (rs3212986), and ERCC2 (rs13181) in 56 FFPE DNA samples. By using PCR, followed by size-based gel electrophoresis, we also examined TYMS 5' untranslated region 2R/3R repeats and GSTT1 deletions in 50 FFPE DNA samples and 34 DNAs extracted from fresh-frozen tissues and cell lines. Each polymorphism was analyzed by two independent runs. We found that iPLEX biomarker assays measuring single-nucleotide polymorphisms provided consistent concordant results. However, by using FFPE DNA, size-based PCR biomarkers (GSTT1 and TYMS 5' untranslated region) were discrepant in 32.7% (16/49, with exact 95% CI, 19.9%-47.5%; exact binomial confidence limit test) and 4.2% (2/48, with exact 95% CI, 0.5%-14.3%) of cases, respectively, whereas no discrepancies were observed using intact genomic DNA. Our findings suggest that DNA from FFPE material can be used to reliably test single-nucleotide polymorphisms. However, results based on size-based PCR biomarkers, and particularly GSTT1 deletions, using FFPE DNA need to be interpreted with caution. Independent repeated assays should be performed on all cases to assess potential discrepancies. Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

  19. Isentropic compression studies using the NHMFL single turn

    Energy Technology Data Exchange (ETDEWEB)

    Tasker, Douglas G [Los Alamos National Laboratory; Mielke, Charles [Los Alamos National Laboratory; Rodriguez, George [Los Alamos National Laboratory; Rickel, Dwight [Los Alamos National Laboratory

    2010-10-19

    Magnetic isentropic compression experiments (ICE) provide the most accurate shock free compression data for materials at megabar stresses. Recent ICE experiments performed on the Sandia Z-machine (Asay, 1999) and at the Los Alamos High Explosive Pulsed Power facility (Tasker, 2006) are providing our nation with data on material properties in extreme dynamic high stress environments. The LANL National High Magnetic Field Laboratory (NHMFL) can offer a less complex ICE experiment at high stresses (up to {approx}1Mbar) with a high sample throughput and relatively low cost. This is not to say that the NHMFL technique will replace the other methods but rather complement them. For example, NHMFL-ICE is ideal for the development of advanced diagnostics, e.g., to detect phase changes. We will discuss the physics of the NHMFL-ICE experiments and present data from the first proof-of-principle experiments that were performed in September 2010.

  20. Turning nuclear communications inside out

    International Nuclear Information System (INIS)

    Besenyei, Elisabeth; Czibolya, Laszlo

    2002-01-01

    Due to debates on the security of energy supply in the European Union, the international efforts on the implementation of Kyoto protocol and the forthcoming liberalization of the electrical energy market the attention of Hungarian decision-makers was focused on energy related problems. Discussions started on the future role of nuclear power and anti-nuclear environmentalists became more active in their criticism. Changes were needed in the approach and practice of communication on nuclear energy. Previous practice turned to be inefficient in dialogue with different social and influential groups. Public information could not be considered any more as an activity explaining measures to cope with incidents and accidents or giving technical answers to mostly superficial statements on allegedly unsafe features and solutions in nuclear industry. It was time to change the paradigm and to turn the communication into a powerful tool to put forward the arguments, to show the achievements and facts and to explain the efforts in addressing public concerns. The new paradigm turned the previous outside-in approach to a new inside-out type of behavior. Instead of reacting to the attacks coming from outside the new approach means first of all commitment to be open and pro-active in communication and to act in close cooperation with all interested organizations and institutions. The three pillars of the new paradigm, commitment, communication and co-operation are applicable not only for the nuclear industry, but also for the governmental agencies (regulatory bodies, health and emergency authorities etc.) and for the wide range of technical, scientific and civil organizations. Public information should be turned from a burden to a challenge for open, technically valid and honest dialogue. This active communication approach is illustrated by some new initiatives in public information in Hungary. Following the successful Nuclear Academy for Journalists formed new Section of Nuclear

  1. Left-Turning Vehicle Trajectory Modeling and Guide Line Setting at the Intersection

    Directory of Open Access Journals (Sweden)

    Fulu Wei

    2014-01-01

    Full Text Available When left-turning vehicles are released from the multiple left-turning lanes at the signalized intersection, there will be conflicts among them, and the conflicts will affect the traffic operation and safety. In order to solve the problem, by extracting running trajectories of left-turning vehicles and analyzing distribution characteristics of trajectories, velocity changing characteristics, and flow changing characteristics, the left-turning vehicle’s trajectory model was established. On the basis of the above research, taking an example of quadruple left-turning lanes, the idea of setting left-turning guide line at the intersection was proposed. Through instance verification, we could get the conclusion that the method of using left-turning guide line to control vehicles’ turning process can effectively reduce traffic conflicts and delay and improve traffic efficiency.

  2. Rapid magnetic solid-phase extraction based on monodisperse magnetic single-crystal ferrite nanoparticles for the determination of free fatty acid content in edible oils.

    Science.gov (United States)

    Wei, Fang; Zhao, Qin; Lv, Xin; Dong, Xu-Yan; Feng, Yu-Qi; Chen, Hong

    2013-01-09

    This study proposes a rapid magnetic solid-phase extraction (MSPE) based on monodisperse magnetic single-crystal ferrite (Fe(3)O(4)) nanoparticles (NPs) for determining the quantities of eight free fatty acids (FFAs), including palmitic acid (C16:0), stearic acid (C18:0), oleic acid (C18:1), linoleic acid (C18:2), linolenic acid (C18:3), arachidic acid (C20:0), eicosenoic acid (C20:1), and behenic acid (C22:0) in oil. The amine-functionalized mesoporous Fe(3)O(4) magnetic NPs were applied as a sorbent for MSPE of FFAs from oil samples in a process that is based on hydrophilic interaction. The extraction can be completed rapidly in a dispersive mode with the aid of vigorous vortex. Additional tedious processing steps such as centrifugation and evaporation of organic solvent were not necessary with this procedure. Furthermore, esterification of FFAs can be accomplished during the desorption procedure by using methanol/sulfuric acid (99:1, v/v) as the desorption solvent. Several parameters affecting the extraction efficiency were investigated, including the matrix solvent for extraction, the desorption solvent and desorption time, and the amount of sorbent and extraction time. The pretreatment process was rapid under optimal conditions, being accomplished within 15 min. When coupled with gas chromatography-flame ionization detection (GC-FID), a rapid, simple, and convenient MSPE-GC-FID method for the determination of FFAs in oil samples was established with a total analysis time within 25 min. The limits of detection for the target FFAs were found to be 7.22-26.26 ng/mL. Recoveries in oil samples were in the range of 81.33-117.75%, with RSDs of <6.4% (intraday) and <6.9% (interday). This method was applied successfully to the analysis of dynamic FFA formation in four types of edible oils subjected to an accelerated storage test. The simple, rapid, and cost-effective method developed in the current study offers a potential application for the extraction and

  3. Multi-method analysis of functionalized single-walled carbon nanotubes for cesium liquid–solid extraction

    Energy Technology Data Exchange (ETDEWEB)

    Kaper, Helena [Institut de Chimie Séparative de Marcoule, UMR 5257 CEA/CNRS/ENSCM/Université Montpellier 2, BP 17171, F-30207 Bagnols-sur-Cèze (France); Laboratoire de Synthèse et Fonctionnalisation des Céramiques, UMR 3080 Saint Gobain/CNRS, F-84306 Cavaillon (France); Nicolle, Jimmy [Institut de Chimie Séparative de Marcoule, UMR 5257 CEA/CNRS/ENSCM/Université Montpellier 2, BP 17171, F-30207 Bagnols-sur-Cèze (France); Cambedouzou, Julien, E-mail: julien.cambedouzou@enscm.fr [Institut de Chimie Séparative de Marcoule, UMR 5257 CEA/CNRS/ENSCM/Université Montpellier 2, BP 17171, F-30207 Bagnols-sur-Cèze (France); Grandjean, Agnès [Institut de Chimie Séparative de Marcoule, UMR 5257 CEA/CNRS/ENSCM/Université Montpellier 2, BP 17171, F-30207 Bagnols-sur-Cèze (France)

    2014-09-15

    We report a detailed analysis of single-walled carbon nanotubes (SWCNTs) functionalized with Dimethyl Acetylenedicarboxylate (DMAD) using a large range of techniques, involving different spectroscopic analysis, transmission electron microscopy, thermogravimetric analysis, and X-ray diffraction. SWCNT functionalization is based on a simple protocol associating ultrasonication and moderate heating under endogenous pressure of the molecules to be grafted. The complete and careful characterization of the resulting grafted SWCNTs revealed that a grafting rate of more than 1 molecule per nanometer of tube length is achieved. Furthermore an original quantification of the grafting homogeneity is developed using the micro-Raman mapping technique. Sorption experiments of Cs{sup +} ions onto grafted SWCNTs resulted in a high loading capacity, i.e. about 250 mg of Cs{sup +} per gram of grafted carbon nanotubes, opening exciting opportunities towards the design of carbon nanotube based materials for liquid treatment applications. - Highlights: • We functionalized single-walled carbon nanotubes by dimethyl acetylenedicarboxylate. • We performed a complete characterization using a wide range of analytical techniques. • We quantified grafting homogeneity using a micro-Raman mapping based procedure. • A Cesium sorption rate of 250 mg per gram of grafted nanotubes was measured.

  4. Breaking New Ground with High Resolution Turn-By-Turn BPMs at the ESRF

    CERN Document Server

    Farvacque, L; Scheidt, K

    2001-01-01

    This High-Resolution, Turn-by-Turn BPM system is a low-cost extension to the existing BPM system, based on the RF-multiplexing concept, used for slow Closed-Orbit measurements. With this extension Beam Position measurements in both planes, at all (224) BPMs in the 844 m ESRF Storage Ring, for up to 2048 Orbit Turns with 1 μm resolution are performed. The data acquisition is synchronised to a single, flat 1 μs, transverse deflection kick to the 1μs beamfill in the 2.8μs revolution period. The high quality of this synchronisation, together with the good reproducibility of the deflection kick and the overall stability of the Closed Orbit beam allows to repeat the kick and acquisition in many cycles. The subsequent averaging of the data obtained in these cycles yields the 1um resolution. The latter allows lattice measurements with high precision such as the localisation of very small focussing errors and modulation in Beta values and phase advances. It also finds an unique ...

  5. Evaluation of cutting force uncertainty components in turning

    DEFF Research Database (Denmark)

    Axinte, Dragos Aurelian; Belluco, Walter; De Chiffre, Leonardo

    2000-01-01

    A procedure is proposed for the evaluation of those uncertainty components of a single cutting force measurement in turning that are related to the contributions of the dynamometer calibration and the cutting process itself. Based on an empirical model including errors form both sources, the unce...

  6. Single pot synthesized gold nanoparticles using Hippophae rhamnoides leaf and berry extract showed shape-dependent differential nanobiotechnological applications.

    Science.gov (United States)

    Sharma, Bhavana; Deswal, Renu

    2018-04-04

    A facile one-pot green synthesis of gold nanoparticles (AuNPs) with different geometries was achieved using an underutilized Himalayan bioresource Hippophae rhamnoides. Aqueous leaf (LE) and berry extracts (BE) showed rapid synthesis of monodispersed spherical LEAuNPs (27 ± 3.2 nm) and anisotropic BEAuNPs (55 ± 4.5 nm) within 2 and 15 min, respectively. The Fourier-transform infrared (FTIR) spectroscopy showed involvement of polyphenolics/flavonoids in AuNPs reduction. LE AuNPs (IC 50 49 µg) exhibited higher antioxidant potential than BE AuNPs (IC 50 57 µg). Both BE nanotriangles and LE nanospheres exhibited cytotoxicity against Jurkat cell lines. These nanocatalysts also exhibited effective (80-99%) reductive degradation of structurally different carcinogenic azo dyes. Kinetic studies revealed that BE nanotriangles exhibited higher catalytic efficiency (14-67%) than LE nanospheres suggesting shape-dependent regulation of biological activities. The gas chromatography-mass spectrometry (GC-MS) analysis confirmed conversion of toxic methyl orange dye to non-toxic intermediates. Probable degradation mechanism involving adsorption and catalytic reduction of azo bonds was proposed. The present synthesis protocol provided a facile and energy saving procedure for rapid synthesis of highly stable nanoparticles with significant antioxidant and anticancer potential. This is the first report of H. rhamnoides-mediated green synthesis of multipurpose AuNPs as antioxidant, anticancer and nanocatalytic agents for treatment of dye contaminated waste water and future therapeutic applications.

  7. William Friedman, Geneticist Turned Cryptographer.

    Science.gov (United States)

    Goldman, Irwin L

    2017-05-01

    William Friedman (1891-1969), trained as a plant geneticist at Cornell University, was employed at Riverbank Laboratories by the eccentric millionaire George Fabyan to work on wheat breeding. Friedman, however, soon became intrigued by and started working on a pet project of Fabyan's involving the conjecture that Francis Bacon, a polymath known for the study of ciphers, was the real author of Shakespeare's plays. Thus, beginning in ∼1916, Friedman turned his attention to the so called "Baconian cipher," and developed decryption techniques that bore similarity to approaches for solving problems in population genetics. His most significant, indeed pathbreaking, work used ideas from genetics and statistics, focusing on analysis of the frequencies of letters in language use. Although he had transitioned from being a geneticist to a cryptographer, his earlier work had resonance in his later pursuits. He soon began working directly for the United States government and produced solutions used to solve complex military ciphers, in particular to break the Japanese Purple code during World War II. Another important legacy of his work was the establishment of the Signal Intelligence Service and eventually the National Security Agency. Copyright © 2017 by the Genetics Society of America.

  8. Notes on the Spatial Turn

    Directory of Open Access Journals (Sweden)

    Stipe Grgas

    2012-06-01

    Full Text Available On the basis of ever-mounting evidence, amongst which is the “zone” problematic of the Zadar conference that occassioned these notes, it can be concluded that the spatial turn has insinuated itself as an all-pervading heuristic tool throughout the humanities and the social sciences. The extent to which space and spatiality have usurped the central stage in the various branches of reasearch can be gauged by admonishments that what we are witnessing is a new fundamentalism that has simply inverted the terms of the dualism of time and space (May and Thrift 2001: “Introduction”. According to Michael Dear the sway of space is manifested in multifold ways: in the ubiquity of spatial analysis in social theories and practices; in the explosion of publications devoted to the exploration of the interface of the social and the spatial; in the reintegration of human geography into various domains of knowledge; in the focus given to difference and the consequent diversification of theoretical and empirical practices; in a theoretically informed exploration of the relation between geographical knowledge and social action; and, finally, in the unprecedented proliferation of research agendas and publications pertaining to these isuuses (Dear 2001: 24. Two recent collections of papers are indicative of the ubiquity of spatial issues in scholarly work.

  9. A single step solid-phase extraction method for complete separation of sterol oxidation products in food lipids.

    Science.gov (United States)

    Azadmard-Damirchi, Sodeif; Dutta, Paresh C

    2009-01-02

    One of the crucial steps in determination of sterol oxidation products (SOPs) in foods is their enrichment and purifications by various preparative methods for further analysis by GC and GC-MS. Among the preparative methods, SPE of various adsorbents and solvent systems, are being used most widely. At present, no single step SPE method is suitable to completely separate the SOPs. In this study, a SPE (1g silica) method, suitable for both transesterified and cold saponified oil samples, was developed to separate completely SOPs from other lipid components. This method resulted in high recovery from rapeseed oil of added 5beta,6beta-epoxycholestan-3beta-ol (94-96%), cholest-5-en-3beta-ol-7-one(94%), cholestane-3beta,5alpha,6beta-triol (88-91%), cholest-5-en-3beta,7alpha-diol and 5alpha,6alpha-epoxycholestan-3beta-ol (88-90%). The method has a high sample capacity of up to 1g transesterified or cold-saponified oil sample. The method was tested and applied to different vegetable oils and to monitor the effects of refining processes on POPs in hazelnut oil.

  10. Clinical evaluation of an automated turning bed.

    Science.gov (United States)

    Melland, H I; Langemo, D; Hanson, D; Olson, B; Hunter, S

    1999-01-01

    The purposes of this study were to assess client comfort and sleep quality, client physiologic response (skin and respiratory status), the effect on the need for caregiver assistance, and cost when using an automated turning bed. Nonexperimental, evaluative study. Twenty-four adult home or long-term care resident subjects who had a degenerative disease, spinal cord injury, stroke, cerebral palsy, or back surgery. Each subject agreed to use the automated turning bed for four weeks. Researchers completed a demographic survey and skin assessment, and assessed each subject for pressure ulcer risk and for the need of assistance of a care giver for turning before and after the four weeks of using the turning bed. Subjects rated the turning bed in terms of comfort and sleep quality. Subjects rated the turning bed as more comfortable than their own bed and expressed satisfaction at the pain relief attained when on the turning bed. While using the turning bed, there was a significant improvement in sleep quality. No skin breakdown or deterioration in respiratory status occurred. Fewer subjects required the assistance of a caregiver for turning when on the turning bed. This automated turning bed shows great promise in meeting a need for patients with limited mobility whether they are homebound or in a residential community. Future studies that further investigate use of the turning bed for postoperative back patients while still in the acute care setting are indicated. Replicative studies with a larger sample size are also indicated.

  11. 32 CFR 636.23 - Turning movements.

    Science.gov (United States)

    2010-07-01

    ... Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL... movements. (a) U-turns are prohibited on all streets in the cantonment area. (b) Right-turns will be made from a position as close to the right edge or right curb of the roadway as possible. (c) Left-turns...

  12. Potential of maize single-cross hybrids for extraction of inbred lines using the mean components and mixed models with microsatellite marker information.

    Science.gov (United States)

    Balestre, M; Von Pinho, R G; Souza, J C; Machado, J C

    2008-10-21

    The present study examined the importance of mean (m+a' and d) components in the performance of single-cross hybrids for the formation of new populations and determined the contribution of the mixed model (best linear unbiased predictor of random effects, BLUP) method associated with molecular markers for the choice of crosses to obtain interpopulation hybrids. Ten single-cross commercial hybrids of different companies were used for this purpose, producing all possible double-cross hybrids through a complete diallel. The hybrids were evaluated in 15 locations in the agricultural year 2005/2006, using randomized complete block design with three repetitions. In three of these locations, estimates of m+a' and d were obtained. DNA was extracted from the single-cross hybrids and 20 SSR primers were used, nine of which were linked to QTL for yield. There was no correlation between m+a' of the single-cross hybrids with general combining ability (r = -0.15) inferring that populations with lines with high means do not always produce good hybrids. Also, it was observed that the correlation between the genetic distances with specific combining ability varied from 0.31 to 0.80 in the inter-group hybrids, while in the intra-group hybrids these estimates were low and non-significant. The heritability value obtained by BLUP was high and greater than that obtained by ordinary least squares (h(2) = 0.95 and 0.86), confirming the greater selection accuracy by the BLUP method. There were no differences between the accuracy values obtained with microsatellite information and without this information, inferring that there was no advantage of progenitor information on balanced data. It can be concluded that the estimate m+a' should not be used as a deciding parameter about the potential for extracting lines from a given population. The heritability and accuracy values obtained by BLUP allow the inference that it is possible to predict success in the choice of progenitors to obtain

  13. The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: twenty-something years on.

    Science.gov (United States)

    Chomczynski, Piotr; Sacchi, Nicoletta

    2006-01-01

    Since its introduction, the 'single-step' method has become widely used for isolating total RNA from biological samples of different sources. The principle at the basis of the method is that RNA is separated from DNA after extraction with an acidic solution containing guanidinium thiocyanate, sodium acetate, phenol and chloroform, followed by centrifugation. Under acidic conditions, total RNA remains in the upper aqueous phase, while most of DNA and proteins remain either in the interphase or in the lower organic phase. Total RNA is then recovered by precipitation with isopropanol and can be used for several applications. The original protocol, enabling the isolation of RNA from cells and tissues in less than 4 hours, greatly advanced the analysis of gene expression in plant and animal models as well as in pathological samples, as demonstrated by the overwhelming number of citations the paper gained over 20 years.

  14. The alveolar process following single-tooth extraction: a study of maxillary incisor and premolar sites in man.

    Science.gov (United States)

    Misawa, Mônica; Lindhe, Jan; Araújo, Mauricio G

    2016-07-01

    The present investigation was performed to determine some dimensional alterations that occur in the alveolar process of the incisor and premolar sites of the maxilla following tooth removal. Computer-assisted cone-beam computed tomography (CBCT) scans were obtained from the maxilla using an iCAT unit, and involved edentulous and contralateral tooth sites. For each site included in the study, parasagittal and axial reconstructions, 1 mm apart, were made and measurements of different variables (cross-sectional area, height, and width) performed. The study involved 69 subjects and disclosed that the cross-sectional area and the height and width of the alveolar process of the lateral incisor site were the smallest and those of the second premolar the largest. All parameters had been significantly reduced after the completion of the ≥1 year of healing. Thus, the overall (i) cross-sectional area was reduced from 99.1 to 65.0 mm(2) , (ii) the height from 11.5 to 9.5 mm, and (iii) the width from 8.5 to 3.2 mm (marginal 1/3(rd) ), 8.9 to 4.8 mm (middle portion), and 9.0 to 5.7 mm (apical portion). The removal of single tooth caused marked hard tissue diminution. The loss of hard tissue was most pronounced in the buccal and marginal portions of the edentulous ridge that in most sites had acquired a triangular shape. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  15. A 5- Year Comparison of Marginal Bone Level Following Immediate Loading of Single-Tooth Implants Placed in Healed Alveolar Ridges and Extraction Sockets in the Maxilla.

    Directory of Open Access Journals (Sweden)

    Antoine Nicolas Berberi

    2014-01-01

    Full Text Available AbstractPurpose: The aim of present investigation was to evaluate marginal bone level after 5-year follow-up of implants placed in healed ridges and fresh extraction sockets in maxilla with immediate loading protocol.Materials and Methods: Thirty-six patients in need of a single tooth replacement in the anterior maxilla received 42 Astra Tech implants (Astra Tech Implant system™, Dentsply Implants, Mölndal, Sweden. Implants were placed in healed ridges (group I or immediately into extraction sockets (group II. Implants were restored and placed into functional loading immediately by using a prefabricated abutment. Marginal bone level relative to the implant reference point was recorded at implant placement, crown cementation, 12, 36 and 60 months following loading using intra-oral radiographs. Measurements were made on the mesial and distal sides of each implantResults: Overall, two implants were lost from the group II, before final crown cementation: they were excluded from the study and all remaining implants osseointegrated successfully after 5 years of functional loading. The mean change in marginal bone loss after implant placement was 0.267±0.161 for one year, and 0.265±0.171 for three years and 0.213±0.185 for five years in extraction sockets and was 0.266±0.176 for one year and 0.219±0.175 for three years and 0.194±0.172 for five years in healed ridges group. Significant reduction of marginal bone loss was more pronounced in implants inserted in healed ridges (P

  16. The Ginkgo biloba extract (GbE) protects the kidney from damage produced by a single and low dose of carbon tetrachloride in adult male rats.

    Science.gov (United States)

    Chávez-Morales, R M; Jaramillo-Juárez, F; Rodríguez-Vázquez, M L; Martínez-Saldaña, M C; Del Río, F A Posadas; Garfias-López, J A

    2017-09-05

    Gingko biloba leaves have been used as herbal medicine in China for 5000 years, and the standardized leaf extract (GB-STE) has some beneficial effects in the treatment of age-related, cardiovascular, and neurological diseases. The aim of this study was to investigate the renoprotective effects of the Gingko biloba extract (GbE) against the toxicity of a single and relatively low dose of carbon tetrachloride (CCl 4 ). In male adult Wistar rats, we determined the urine flux, the concentration of total proteins in urine, the concentration of glucose in urine, and the concentration of malondialdehyde (MDA) in renal cortex as well as two markers of renal function (clearance of inulin and p-aminohippurate); we also compared the histological lesions caused by CCl 4 . Carbon tetrachloride increased the urinary concentration of total proteins, and the renal concentration of MDA; however, it did not modify the urine flux, urinary concentration of glucose, nor the inuline or the p-aminohipurate clearances. Morphologically, CCl 4 generated some tubular damage that was more intense in the inner cortex of kidneys. The GbE extract counteracted the effects of CCl 4 on the concentration of total proteins in urine, the concentration of renal MDA, and the renal histological changes. In conclusion the main toxic effects produced by CCl 4 were prevented by the GbE, probably due to their antioxidant properties and the inhibition of the main P450 isoenzyme (CYP2E1) that metabolize CCl 4 . Copyright © 2017 Elsevier GmbH. All rights reserved.

  17. Immediate provisionalisation of single post-extractive implants versus implants placed in healed sites in the anterior maxilla: 1-year results from a multicentre controlled cohort study.

    Science.gov (United States)

    Grandi, Tommaso; Guazzi, Paolo; Samarani, Rawad; Grandi, Giovanni

    2013-01-01

    The purpose of the study was to compare the clinical and aesthetic outcome of single post-extractive implants versus implants placed in a preserved socket after 4 months of healing in the anterior maxilla. All of the implants were immediately non-occlusally loaded. A total of 50 patients were treated in the two groups of study. The Delayed Group had a maxillary tooth (premolar, canine, lateral or central incisor) removed, with immediate socket grafting, followed by implant placement and provisionalisation 4 months later. The Immediate Group had immediate implant placement and provisionalisation. Outcome measures were implant failures, biological and biomechanical complications, peri-implant radiographic bone level changes, and gingival aesthetics. At the 12-month follow-up, two implants failed in the Immediate Group (8%) versus one in the Delayed Group (4%), with a comparable rate of implant failure (P = 0.55). No complications occurred for either group. The 12-month peri-implant bone resorption was similar in both groups (P = 0.23): 0.71 mm (95% CI 0.45, 0.97) in the Immediate Group versus 0.60 mm (95% CI 0.38, 0.82) in the Delayed Group. The mean difference in bone resorption was 0.13 mm (95% CI -0.21, 0.47). An ideal gingival marginal level was reached most frequently in the Delayed Group (83.3% versus 52.1%, P = 0.04). Rates of full closure of the papilla were similar between the two groups (82.6% for the Immediate Group versus 62.5% for the Delayed Group, P = 0.12). Given the limitation that this was not a randomised controlled trial, there were no differences in complications or crestal bone response at immediate post-extractive implants when compared to delayed implants. A delayed protocol might be considered in the aesthetic zone due to the gingival recession that occurs after post-extractive implant placement.

  18. Photosynthetic Performance of the Imidazolinone Resistant Sunflower Exposed to Single and Combined Treatment by the Herbicide Imazamox and an Amino Acid Extract

    Directory of Open Access Journals (Sweden)

    Dobrinka Anastasova Balabanova

    2016-10-01

    Full Text Available The herbicide imazamox may provoke temporary yellowing and growth retardation in IMI-R sunflower hybrids, more often under stressful environmental conditions. Although photosynthetic processes are not the primary sites of imazamox action, they might be influenced; therefore, more information about the photosynthetic performance of the herbicide-treated plants could be valuable for a further improvement of the Clearfield technology. Plant biostimulants have been shown to ameliorate damages caused by different stress factors on plants, but very limited information exists about their effects on herbicide-stressed plants. In order to characterize photosynthetic performance of imazamox-treated sunflower IMI-R plants, we carried out experiments including both single and combined treatments by imazamox and a plant biostimulants containing amino acid extract. We found that imazamox application in a rate of 132 μg per plant (equivalent of 40 g active ingredient ha-1 induced negative effects on both light-light dependent photosynthetic redox reactions and leaf gas exchange processes, which was much less pronounced after the combined application of imazamox and amino acid extract.

  19. Contact effects analyzed by a parameter extraction method based on a single bottom-gate/top-contact organic thin-film transistor

    Science.gov (United States)

    Takagaki, Shunsuke; Yamada, Hirofumi; Noda, Kei

    2018-03-01

    Contact effects in organic thin-film transistors (OTFTs) were examined by using our previously proposed parameter extraction method from the electrical characteristics of a single staggered-type device. Gate-voltage-dependent contact resistance and channel mobility in the linear regime were evaluated for bottom-gate/top-contact (BGTC) pentacene TFTs with active layers of different thicknesses, and for pentacene TFTs with contact-doped layers prepared by coevaporation of pentacene and tetrafluorotetracyanoquinodimethane (F4TCNQ). The extracted parameters suggested that the influence of the contact resistance becomes more prominent with the larger active-layer thickness, and that contact-doping experiments give rise to a drastic decrease in the contact resistance and a concurrent considerable improvement in the channel mobility. Additionally, the estimated energy distributions of trap density in the transistor channel probably reflect the trap filling with charge carriers injected into the channel regions. The analysis results in this study confirm the effectiveness of our proposed method, with which we can investigate contact effects and circumvent the influences of characteristic variations in OTFT fabrication.

  20. Effects of single and combined administration of fermented barley extract and gamma-aminobutyric acid on the development of atopic dermatitis in NC/Nga mice.

    Science.gov (United States)

    Hokazono, Hideki; Omori, Toshiro; Ono, Kazuhisa

    2010-01-01

    We examined the effects single and combined administration of fermented barley extract P (FBEP), prepared from barley-shochu distillery by-products, and gamma-aminobutyric acid (GABA) on the development of atopic dermatitis (AD)-like skin lesions in NC/Nga mice. Single administration of FBEP and GABA dose-dependently reduced the development of AD-like skin lesions in mice. GABA reduced the development of AD-like skin lesions by suppressing serum immunoglobulin E (IgE) and splenocyte interleukin (IL)-4 production, while FBEP reduced skin lesions without affecting the IgE or cytokine production. However, in mice with induced AD-like skin lesions, combined administration of FBEP and GABA decreased serum IgE levels and splenic cell IL-4 production, and increased splenic cell interferon-gamma production. These results suggest that combined administration of FBEP and GABA alleviated AD-like skin lesions in the NC/Nga mice by adjusting the Th1/Th2 balance to a Th1-predominant immune response.

  1. Immediate loading of post-extractive versus delayed placed single implants in the anterior maxilla: outcome of a pragmatic multicenter randomised controlled trial 1-year after loading.

    Science.gov (United States)

    Esposito, Marco; Barausse, Carlo; Pistilli, Roberto; Jacotti, Michele; Grandi, Giovanni; Tuco, Lorenzo; Felice, Pietro

    2015-01-01

    To compare the effectiveness of immediate post-extractive single implants with delayed implants, placed in preserved sockets after 4 months of healing. Implants that achieved an insertion torque of at least 35 Ncm were immediately non-occlusally loaded. Just after tooth extraction, and in the presence of less than 4 mm of vertical loss of the buccal bone in relation to the palatal wall, 106 patients requiring a single immediate post-extractive implant in the maxilla from second to second premolar were randomly allocated to immediate implant placement (immediate group; 54 patients) or to socket preservation using anorganic bovine bone covered by a resorbable collagen barrier (delayed group; 52 patients), according to a parallel group design at three different centres. Bone-to-implant gaps were to be filled with anorganic bovine bone, however this was not carried out in 17 patients (corresponding to 40% of those who should have been grafted). Four months after socket preservation, delayed implants were placed. Implants inserted with an insertion torque of at least 35 Ncm were immediately loaded with non-occluding provisional single crowns, then replaced after 4 months by definitive crowns. Patients were followed up to 1 year after loading. Outcome measures were implant failures, complications, aesthetics assessed using the pink esthetic score (PES), peri-implant marginal bone level changes and patient satisfaction recorded by blinded assessors. Nineteen (35%) implants were not immediately loaded in the immediate group versus 39 (75%) implants in the delayed placement group because an insertion torque superior to 35 Ncm could not be obtained. Six patients dropped out 4 months after loading from the delayed group versus none in the immediate group. Two implants failed in the immediate group (6%) versus none in the delayed group, with the difference showing no statistical significance (difference in proportions = 0.04; 95% CI: -0.03 to 0.11; P = 0.187). Eight minor

  2. Facial bone alterations on maxillary anterior single implants for immediate placement and provisionalization following tooth extraction: a superimposed cone beam computed tomography study.

    Science.gov (United States)

    Morimoto, Taichiro; Tsukiyama, Yoshihiro; Morimoto, Keizo; Koyano, Kiyoshi

    2015-12-01

    The purpose of this cone beam computed tomography (CBCT) study was to describe the facial bone changes around single implants for immediate placement and provisionalization following tooth extraction in the maxillary anterior. The data between 2008 and 2013 were collected retrospectively. Superimposed facio-palatal cross-sectional CBCT images for the implants were derived from preoperative and postoperative radiographs via standardized CBCT processes. Horizontal and vertical facial measurements on the implants were identified at preoperative and approximately 1-year postoperative follow-ups. Correlation coefficient for those parameters was evaluated. A total of 12 single implants in 12 patients were included in this study. The mean loading period was 13.3 months (range 12-15 months). The median data of preoperative bone thickness 0.54 mm (A), preoperative vertical bone level 1.46 mm (B), postoperative bone thickness 1.77 mm (C), postoperative vertical bone level 1.08 mm (D), horizontal distance from outer surface of preoperative facial bone to implant surface 2.08 mm (E), horizontal gap distance 1.41 mm (E-A), horizontal bone resorption -0.26 mm (E-C), and vertical bone resorption -0.25 mm (B-D) were obtained. The data at the implant platform level (IPL) were selected for the horizontal measurements. Spearman's analysis demonstrated statistically significant correlations between B and D, C and E, E and E-A, and B and E-C (P Immediate placement and provisionalization of single implants procedure in the maxillary anterior showed excellent outcomes with the small facial bone alterations around the implants. Neither preoperative facial bone thickness nor horizontal gap distance influenced the amount of facial bone resorptions. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  3. Online hyphenation of extraction, Sephadex LH-20 column chromatography, and high-speed countercurrent chromatography: A highly efficient strategy for the preparative separation of andrographolide from Andrographis paniculata in a single step.

    Science.gov (United States)

    Zhang, Ying-Qi; Wang, Shan-Shan; Han, Chao; Xu, Jin-Fang; Luo, Jian-Guang; Kong, Ling-Yi

    2017-12-01

    A novel isolation strategy, online hyphenation of ultrasonic extraction, Sephadex LH-20 column chromatography combined with high-speed countercurrent chromatography, was developed for pure compounds extraction and purification. Andrographolide from Andrographis paniculata was achieved only in a single step purification protocol via the present strategy. The crude powder was ultrasonic extracted and extraction was pumped into Sephadex LH-20 column directly to cut the nontarget fractions followed by the second-dimensional high-speed countercurrent chromatography, hyphenated by a six-port valve equipped at the post-end of Sephadex LH-20 column, for the final purification. The results yielded andrographolide with the amount of 1.02 mg and a purity of 98.5% in a single step, indicating that the present method is effective to harvest target compound from medicinal plant. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Realistic page-turning of electronic books

    Science.gov (United States)

    Fan, Chaoran; Li, Haisheng; Bai, Yannan

    2014-01-01

    The booming electronic books (e-books), as an extension to the paper book, are popular with readers. Recently, many efforts are put into the realistic page-turning simulation o f e-book to improve its reading experience. This paper presents a new 3D page-turning simulation approach, which employs piecewise time-dependent cylindrical surfaces to describe the turning page and constructs smooth transition method between time-dependent cylinders. The page-turning animation is produced by sequentially mapping the turning page into the cylinders with different radii and positions. Compared to the previous approaches, our method is able to imitate various effects efficiently and obtains more natural animation of turning page.

  5. Recognition and one-pot extraction of right- and left-handed semiconducting single-walled carbon nanotube enantiomers using fluorene-binaphthol chiral copolymers.

    Science.gov (United States)

    Akazaki, Kojiro; Toshimitsu, Fumiyuki; Ozawa, Hiroaki; Fujigaya, Tsuyohiko; Nakashima, Naotoshi

    2012-08-01

    Synthesized single-walled carbon nanotubes (SWNTs) are mixtures of right- and left-handed helicity and their separation is an essential topic in nanocarbon science. In this paper, we describe the separation of right- and left-handed semiconducting SWNTs from as-produced SWNTs. Our strategy for this goal is simple: we designed copolymers composed of polyfluorene and chiral bulky moieties because polyfluorenes with long alkyl-chains are known to dissolve only semiconducting SWNTs and chiral binaphthol is a so-called BINAP family that possesses a powerful enantiomer sorting capability. In this study, we synthesized 12 copolymers, (9,9-dioctylfluorene-2,7-diyl)x((R)- or (S)-2,2'-dimethoxy-1,1'-binaphthalen-6,6-diyl)y, where x and y are copolymer composition ratios. It was found that, by a simple one-pot sonication method, the copolymers are able to extract either right- or left-handed semiconducting SWNT enantiomers with (6,5)- and (7,5)-enriched chirality. The separated materials were confirmed by circular dichroism, vis-near IR and photoluminescence spectroscopies. Interestingly, the copolymer showed inversion of SWNT enantiomer recognition at higher contents of the chiral binaphthol moiety. Molecular mechanics simulations reveal a cooperative effect between the degree of chirality and copolymer conformation to be responsible for these distinct characteristics of the extractions. This is the first example describing the rational design and synthesis of novel compounds for the recognition and simple sorting of right- and left-handed semiconducting SWNTs with a specific chirality.

  6. Single patient doses of {sup 99m}Tc-HDP: Assessment of radiochemical purity, sterility and extractables from a polypropylene syringe over six hours

    Energy Technology Data Exchange (ETDEWEB)

    Parkes, S.L.; Varelis, P. [St George Hospital, Kogarah, NSW (Australia). Department of Nuclear Medicine

    1997-12-01

    Full text: The purpose of this investigation was to determine the radiochemical purity (RCP), sterility and extractables for {sup 99m}Tc oxidronate ({sup 99m}Tc-HDP) stored in polypropylene syringes over < six-hour period. The radiochemical purity was determined using a two-strip ITLC procedure, performed at time 0, 1, 2, 4, 6 hours. The sterility and endotoxin levels were tested by a NATA accredited laboratory, after allowing the radiopharmaceutical to stand at room temperature for six hours in the syringes. Plasticisers and other likely compounds that could be extracted from the syringes into the aqueous solution were determined by high pressure liquid chromatography (HPLC) diode array detection. This analysis involved shaking normal saline in a syringe over night and then injecting an aliquot of this solution onto a C18 analytical column and monitoring the effluent at 200 and 253 nm. The radiochemical purity of {sup 99m}Tc-HDP did not significantly change over the course of the study and remained above the recommended RCP for this radiopharmaceutical. Furthermore, at six hours the RCP of {sup 99m}Tc-HDP stored in both the manufacturer`s vial and a syringe were identical. Sterility testing of {sup 99m}Tc-HDP stored in syringes showed no microbial growth and less than 10 endotoxin units/mL (pass). The HPLC analysis did not show the presence of any extraneous compounds in the aqueous solution. Single patient doses of {sup 99m}Tc-HDP stored in polypropylene syringes over a six-hour period fulfill all the quality control requirements for administration to humans.

  7. Mechanics of the Fouetté turn.

    Science.gov (United States)

    Imura, Akiko; Yeadon, M R

    2010-12-01

    The Fouetté turn in classical ballet is performed repeatedly on one leg with swinging of the free limbs, producing a continued sequence of turns with one turn leading into the next. The purpose of this study was to determine the possible time history profiles of the twisting torque between the supporting leg and the remainder of the body that will allow continued performances of the Fouetté turn. Simulations were performed using a model which comprised the supporting leg and the remainder of the body to find torque profiles that maintain the initial angular velocity so that the state after one revolution is the same as the initial state. The solution space of torque profiles was determined for various rotation times and coefficients of friction between foot and floor. As the time for one revolution became shorter the solution space became smaller and for a given turn time there was a lower limit on the coefficient of friction. As the frictional coefficient became smaller the solution space became smaller and for a given coefficient there was a lower limit on the turn time. Turns of a given tempo can be performed on floors with different friction by modifying the twisting torque profile. When a turn is completed with a net change in angular velocity this can be compensated for in the next turn by adjusting the twisting torque profile. Copyright © 2010 Elsevier B.V. All rights reserved.

  8. A novel strategy with standardized reference extract qualification and single compound quantitative evaluation for quality control of Panax notoginseng used as a functional food.

    Science.gov (United States)

    Li, S P; Qiao, C F; Chen, Y W; Zhao, J; Cui, X M; Zhang, Q W; Liu, X M; Hu, D J

    2013-10-25

    Root of Panax notoginseng (Burk.) F.H. Chen (Sanqi in Chinese) is one of traditional Chinese medicines (TCMs) based functional food. Saponins are the major bioactive components. The shortage of reference compounds or chemical standards is one of the main bottlenecks for quality control of TCMs. A novel strategy, i.e. standardized reference extract based qualification and single calibrated components directly quantitative estimation of multiple analytes, was proposed to easily and effectively control the quality of natural functional foods such as Sanqi. The feasibility and credibility of this methodology were also assessed with a developed fast HPLC method. Five saponins, including ginsenoside Rg1, Re, Rb1, Rd and notoginsenoside R1 were rapidly separated using a conventional HPLC in 20 min. The quantification method was also compared with individual calibration curve method. The strategy is feasible and credible, which is easily and effectively adapted for improving the quality control of natural functional foods such as Sanqi. Copyright © 2013 Elsevier B.V. All rights reserved.

  9. Determination of synephrine in bitter orange raw materials, extracts, and dietary supplements by liquid chromatography with ultraviolet detection: single-laboratory validation.

    Science.gov (United States)

    Roman, Mark C; Betz, Joseph M; Hildreth, Jana

    2007-01-01

    A method has been developed to quantify synephrine in bitter orange raw material, extracts, and dietary supplements. Single-laboratory validation has been performed on the method to determine the repeatability, accuracy, selectivity, limit of detection/limit of quantification (LOQ), ruggedness, and linearity for p-synephrine and 5 other biogenic amines: octopamine, phenylephrine (m-synephrine), tyramine, N-methyltyramine, and hordenine, which may be present in bitter orange. p-Synephrine was found to be the primary biogenic amine present in all materials tested, accounting for >80% of the total biogenic amine content in all samples except a finished product. Repeatability precision for synephrine was between 1.48 and 3.55% RSD. Synephrine recovery was between 97.5 and 104%. The minor alkaloids were typically near the LOQ of the method (300-900 microg/g) in the test materials, and between-day precision for the minor compounds was poor because interferences could sometimes be mistakenly identified as one of the minor analytes. Recoveries of the minor components ranged from 99.1 to 103% at approximately 6000 microg/g spike level, to 90.7 to 120% at 300 microg/g spike level.

  10. Characterization of gold nanoparticle uptake by tomato plants using enzymatic extraction followed by single-particle inductively coupled plasma-mass spectrometry analysis.

    Science.gov (United States)

    Dan, Yongbo; Zhang, Weilan; Xue, Runmiao; Ma, Xingmao; Stephan, Chady; Shi, Honglan

    2015-03-03

    Plant uptake and accumulation of nanoparticles (NPs) represent an important pathway for potential human expose to NPs. Consequently, it is imperative to understand the uptake of accumulation of NPs in plant tissues and their unique physical and chemical properties within plant tissues. Current technologies are limited in revealing the unique characteristics of NPs after they enter plant tissues. An enzymatic digestion method, followed by single-particle inductively coupled plasma-mass spectrometry (SP-ICP-MS) analysis, was developed for simultaneous determination of gold NP (AuNP) size, size distribution, particle concentration, and dissolved Au concentration in tomato plant tissues. The experimental results showed that Macerozyme R-10 enzyme was capable of extracting AuNPs from tomato plants without causing dissolution or aggregation of AuNPs. The detection limit for quantification of AuNP size was 20 nm, and the AuNP particle concentration detection limit was 1000 NPs/mL. The particle concentration recoveries of spiked AuNPs were high (79-96%) in quality control samples. The developed SP-ICP-MS method was able to accurately measure AuNP size, size distribution, and particle concentration in the plant matrix. The dosing study indicated that tomato can uptake AuNPs as intact particles without alternating the AuNP properties.

  11. A cultural turn in New Testament studies?

    African Journals Online (AJOL)

    2016-06-30

    Jun 30, 2016 ... The late twentieth century's 'linguistic turn' marked the beginning of a new consciousness in hermeneutics and even epistemology in New Testament (NT) studies.1 This turn was related to a larger spectrum of changes sometimes referred to as 'culture wars' in the human and social sciences.2 These ...

  12. performance characteristics of a cam turning attachment

    African Journals Online (AJOL)

    Dr Obe

    up of a suitable flexible shaft, a lathe spindle clutch and a shaft supported in ball bearings to carry and drive the master piece. This is shown in figure. 1. The hydraulic turning unit which is intended for cylindrical turning has been modified and used in conjunction with the drive system, as shown in figure. 2, for non cylindrical ...

  13. Towards a Practice Turn in EU Studies

    DEFF Research Database (Denmark)

    Adler-Nissen, Rebecca

    2016-01-01

    the potential of a practice turn in EU studies for both theory (overcoming dualism, replacing substantialism with processualism and rethinking power) and methods (including unstructured interviews, fieldwork and participant observation). A practice turn will force us to rethink core assumptions about the EU...

  14. Kantian Turning Point in Gadamer's Philosophical Hermeneutics

    Directory of Open Access Journals (Sweden)

    Kristína Bosáková

    2016-11-01

    Full Text Available The paper is treating the theme of a Kantian turning-point in the philosophical hermeneutics of H.- G. Gadamer based on of the harmonic relationship between metaphysics and science in Kantian philosophy from the point of view of the philosophical hermeneutics of Gadamer. The philosophical work of Kant had such an influence on Gadamer that without exaggerating we can talk about the Kantian turning-point in Gadamerian hermeneutics. Grondin, a former student of Gadamer, is talking about Kantian turning-point on the field of aesthetics, but in reality Kantian turning-point means much more than a mere change in the reception of the concept of judgement. It is a discovery of harmonical relationship between the beauty and the moral, between the reason and the sensitivity, between the modern sciences and the metaphysical tradition in the Kantian philosophy, made by Gadamer. This is what we call the Kantian turning-point in Gadamerian hermeneutics.

  15. METHODICAL MODEL FOR TEACHING BASIC SKI TURN

    Directory of Open Access Journals (Sweden)

    Danijela Kuna

    2013-07-01

    Full Text Available With the aim of forming an expert model of the most important operators for basic ski turn teaching in ski schools, an experiment was conducted on a sample of 20 ski experts from different countries (Croatia, Bosnia and Herzegovina and Slovenia. From the group of the most commonly used operators for teaching basic ski turn the experts picked the 6 most important: uphill turn and jumping into snowplough, basic turn with hand sideways, basic turn with clapping, ski poles in front, ski poles on neck, uphill turn with active ski guiding. Afterwards, ranking and selection of the most efficient operators was carried out. Due to the set aim of research, a Chi square test was used, as well as the differences between frequencies of chosen operators, differences between values of the most important operators and differences between experts due to their nationality. Statistically significant differences were noticed between frequencies of chosen operators (c2= 24.61; p=0.01, while differences between values of the most important operators were not obvious (c2= 1.94; p=0.91. Meanwhile, the differences between experts concerning thier nationality were only noticeable in the expert evaluation of ski poles on neck operator (c2=7.83; p=0.02. Results of current research are reflected in obtaining useful information about methodological priciples of learning basic ski turn organization in ski schools.

  16. Determination of oil reservoir radiotracer (S{sup 14}CN{sup -}) in a single step using a plastic scintillator extractive resin

    Energy Technology Data Exchange (ETDEWEB)

    Bagan, H.; Tarancon, A. [Departament de Quimica Analitica, Universitat de Barcelona, Diagonal 645, E-08028 Barcelona (Spain); Stavsetra, L. [Department for Reservoir and Exploration Technology, Institute for Energy Technology (IFE), Instituttveien 18, N-2027 Kjeller (Norway); Rauret, G. [Departament de Quimica Analitica, Universitat de Barcelona, Diagonal 645, E-08028 Barcelona (Spain); Garcia, J.F., E-mail: jfgarcia@ub.edu [Departament de Quimica Analitica, Universitat de Barcelona, Diagonal 645, E-08028 Barcelona (Spain)

    2012-07-29

    Highlights: Black-Right-Pointing-Pointer A new procedure for S{sup 14}CN{sup -} radiotracer determination using PS resin was established. Black-Right-Pointing-Pointer The minimum detectable activity for a 100 mL sample is 0.08 Bq L{sup -1}. Black-Right-Pointing-Pointer The minimum quantifiable activity for a 100 mL sample is 0.31 Bq L{sup -1}. Black-Right-Pointing-Pointer PS resin is capable to quantify S{sup 14}CN{sup -} radiotracer samples with errors lower than 5%. Black-Right-Pointing-Pointer PS resin is also capable to quantify complex matrices obtained from oil reservoirs. - Abstract: The analysis of radiotracers is important in the study of oil reservoir dynamics. One of the most widely used radiotracer is S{sup 14}CN{sup -}. Prior to activity measurements by Liquid Scintillation (LS), routine determinations require the pretreatment steps of purification and concentration of the samples using anion exchange columns. The final elution media produces samples with high salt concentration that may lead to problems with phase separation during the LS measurement. Plastic Scintillation (PS) is an alternative technique that provides a solid surface that can be used as a platform for the immobilisation of selective extractants to obtain a PS resin. The proposed procedure unifies chemical separation and sample measurement preparation in a single step, serving to reduce the number of reagents needed and manpower required for the analysis while also avoiding mixed waste production by LS. The objective of this study is to develop a PS resin for the determination of {sup 14}C-labelled thiocyanate radiotracer in water samples. For this purpose, the immobilisation procedure was optimised, including optimisation of the proportion of PS microspheres:extractant and the use of a control blank to monitor the PS resin immobilisation process. The breakthrough volume was studied and the detection and quantification limits for 100 mL of sample were determined to be 0.08 Bq L{sup -1

  17. 14 CFR 23.203 - Turning flight and accelerated turning stalls.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Turning flight and accelerated turning stalls. 23.203 Section 23.203 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... a 30 degree bank. Reduce speed by steadily and progressively tightening the turn with the elevator...

  18. Analysis of trace metals (Cu, Cd, Pb, and Fe) in seawater using single batch nitrilotriacetate resin extraction and isotope dilution inductively coupled plasma mass spectrometry

    International Nuclear Information System (INIS)

    Lee, Jong-Mi; Boyle, Edward A.; Echegoyen-Sanz, Yolanda; Fitzsimmons, Jessica N.; Zhang Ruifeng; Kayser, Richard A.

    2011-01-01

    A simple and accurate low-blank method has been developed for the analysis of total dissolved copper, cadmium, lead, and iron in a small volume (1.3-1.5 mL per element) of seawater. Pre-concentration and salt-separation of a stable isotope spiked sample are achieved by single batch extraction onto nitrilotriacetate (NTA)-type Superflow chelating resin beads (100-2400 beads depending on the element). Metals are released into 0.1-0.5 M HNO 3 , and trace metal isotope ratios are determined by ICPMS. The benefit of this method compared to our previous Mg(OH) 2 coprecipitation method is that the final matrix is very dilute so cone-clogging and matrix sensitivity suppression are minimal, while still retaining the high accuracy of the isotope dilution technique. Recovery efficiencies are sensitive to sample pH, number of resin beads added, and the length of time allowed for sample-resin binding and elution; these factors are optimized for each element to yield the highest recovery. The method has a low procedural blank and high sensitivity sufficient for the analysis of pM-nM open-ocean trace metal concentrations. Application of this method to samples from the Bermuda Atlantic Time-Series Study station provides oceanographically consistent Cu, Cd, Pb, and Fe profiles that are in good agreement with other reliable data for this site. In addition, the method can potentially be modified for the simultaneous analysis of multiple elements, which will be beneficial for the analysis of large number of samples.

  19. Analysis of trace metals (Cu, Cd, Pb, and Fe) in seawater using single batch nitrilotriacetate resin extraction and isotope dilution inductively coupled plasma mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jong-Mi [Department of Earth, Atmospheric, and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Boyle, Edward A., E-mail: eaboyle@mit.edu [Department of Earth, Atmospheric, and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Echegoyen-Sanz, Yolanda; Fitzsimmons, Jessica N. [Department of Earth, Atmospheric, and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Zhang Ruifeng [State Key Laboratory of Estuarine and Coastal Research, East China Normal University, Shanghai 200062 (China); Kayser, Richard A. [Department of Earth, Atmospheric, and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States)

    2011-02-07

    A simple and accurate low-blank method has been developed for the analysis of total dissolved copper, cadmium, lead, and iron in a small volume (1.3-1.5 mL per element) of seawater. Pre-concentration and salt-separation of a stable isotope spiked sample are achieved by single batch extraction onto nitrilotriacetate (NTA)-type Superflow chelating resin beads (100-2400 beads depending on the element). Metals are released into 0.1-0.5 M HNO{sub 3}, and trace metal isotope ratios are determined by ICPMS. The benefit of this method compared to our previous Mg(OH){sub 2} coprecipitation method is that the final matrix is very dilute so cone-clogging and matrix sensitivity suppression are minimal, while still retaining the high accuracy of the isotope dilution technique. Recovery efficiencies are sensitive to sample pH, number of resin beads added, and the length of time allowed for sample-resin binding and elution; these factors are optimized for each element to yield the highest recovery. The method has a low procedural blank and high sensitivity sufficient for the analysis of pM-nM open-ocean trace metal concentrations. Application of this method to samples from the Bermuda Atlantic Time-Series Study station provides oceanographically consistent Cu, Cd, Pb, and Fe profiles that are in good agreement with other reliable data for this site. In addition, the method can potentially be modified for the simultaneous analysis of multiple elements, which will be beneficial for the analysis of large number of samples.

  20. Cellular Reprogramming–Turning the Clock Back

    Indian Academy of Sciences (India)

    Cellular Reprogramming - Turning the Clock Back - Nobel Prize in Physiology or Medicine, 2012. Deepa Subramanyam ... Keywords. Embryonic stem cells; pluripotency; reprogramming; differentiation; Nobel Prize 2012. ... National Centre for Cell Science University of Pune Campus Ganeshkhind Pune 411 007, India.

  1. Turning university professors into competent learners

    NARCIS (Netherlands)

    Stefanova, Eliza; Ilieva, Miroslava; Nikolova, Nikolina; Stefanov, Krassen

    2008-01-01

    Stefanova, E., Ilieva, M., Nikolova, N, & Stefanov, K. (2008). Turning university professors into competent learners. In H. W. Sligte & R. Koper (Eds.), Proceedings of the 4th TENCompetence Open Workshop. Empowering Learners for Lifelong Competence Development: pedagogical, organisational and

  2. Page turning solutions for musicians: a survey.

    Science.gov (United States)

    Wolberg, George; Schipper, Irene

    2012-01-01

    Musicians have long been hampered by the challenge in turning sheet music while their hands are occupied playing an instrument. The sight of a human page turner assisting a pianist during a performance, for instance, is not uncommon. This need for a page turning solution is no less acute during practice sessions, which account for the vast majority of playing time. Despite widespread appreciation of the problem, there have been virtually no robust and affordable products to assist the musician. Recent progress in assistive technology and electronic reading devices offers promising solutions to this long-standing problem. The objective of this paper is to survey the technology landscape and assess the benefits and drawbacks of page turning solutions for musicians. A full range of mechanical and digital page turning products are reviewed.

  3. Conquering the Downwind Turn - SFTE Paper Followup

    National Research Council Canada - National Science Library

    Kolwey, Herman

    2000-01-01

    ...". That's 64 accidents per year to this problem, one piece of which is the turning downwind problem. It also States that: "The way human beings perceive their own movement is fairly well understood". I'm not so sure.

  4. Cellular Reprogramming–Turning the Clock Back

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 18; Issue 6. Cellular Reprogramming - Turning the Clock Back - Nobel Prize in Physiology or Medicine, 2012. Deepa Subramanyam. General Article Volume 18 Issue 6 June 2013 pp 514-521 ...

  5. Method of Rotational Turning With Multifaceted Cutters

    Science.gov (United States)

    Indakov, N.; Gordeev, Y.; Binchurov, A.

    2016-04-01

    The proposed method combines the elements of skew turning (in which a cut layer moves along the cutting edge) and rotary turning (in which the sections of the cutting edge are constantly renewed). This leads to better cooling and, hence, a longer tool life. The required cutting speed is ensured by selection of the required number of revolutions of the cutter; the rotation of the machined shaft corresponds to the rotary feed.

  6. Derrida’s Turn to Franciscan Philosophy

    Directory of Open Access Journals (Sweden)

    Marko Zlomislic

    2008-12-01

    Full Text Available Contemporary French philosophers such as Levinas, Bataille, and Derrida, along with the existentialists Kierkegaard and Nietzsche have all made use of Franciscan insights in order to safeguard the ipseity that cannot be reduced or totalized. In keeping with the taste that concerns me, this paper will examine Derrida’s turn to the poetry of Gerard Manley Hopkins and how such a turn may place Derrida within a catholic and Franciscan tradition.

  7. Phenolic extracts of brewers' spent grain (BSG) as functional ingredients - assessment of their DNA protective effect against oxidant-induced DNA single strand breaks in U937 cells.

    Science.gov (United States)

    McCarthy, Aoife L; O'Callaghan, Yvonne C; Connolly, Alan; Piggott, Charles O; Fitzgerald, Richard J; O'Brien, Nora M

    2012-09-15

    Brewers' spent grain (BSG), a by-product of the brewing industry, contains high amounts of phenolic acids, which have antioxidant effects. The present study examined the ability of BSG extracts to protect against the genotoxic effects of oxidants, hydrogen peroxide (H(2)O(2)), 3-morpholinosydnonimine hydrochloride (SIN-1), 4-nitroquinoline 1-oxide (4-NQO) and tert-butylhydroperoxide (t-BOOH) in U937 cells. Four pale (P1-P4) and four black (B1-B4) BSG extracts were investigated. U937 cells were pre-incubated with BSG extracts, exposed to the oxidants and the DNA damage was measured by the Comet assay. The black BSG extracts (B1-B4) significantly protected against H(2)O(2)-induced DNA damage. Extract B2, which had the highest phenol content, provided the greatest protection. Extracts P2, B2, B3 and B4 provided significant protection against SIN-1-induced DNA damage. None of the extracts protected against DNA damage induced by t-BOOH and 4-NQO. The DNA protective effects of the BSG phenolic extracts may be related to iron chelation. Copyright © 2012 Elsevier Ltd. All rights reserved.

  8. Bodily-visual practices and turn continuation.

    Science.gov (United States)

    Ford, Cecilia E; Thompson, Sandra A; Drake, Veronika

    2012-01-01

    This paper considers points in turn construction where conversation researchers have shown that talk routinely continues beyond possible turn completion, but where we find bodily-visual behavior doing such turn extension work. The bodily-visual behaviors we examine share many features with verbal turn extensions, but we argue that embodied movements have distinct properties that make them well-suited for specific kinds of social action, including stance display and by-play in sequences framed as subsidiary to a simultaneous and related verbal exchange. Our study is in line with a research agenda taking seriously the point made by Goodwin (2000a, b, 2003), Hayashi (2003, 2005), Iwasaki (2009), and others that scholars seeking to account for practices in language and social interaction do themselves a disservice if they privilege the verbal dimension; rather, as suggested in Stivers/Sidnell (2005), each semiotic system/modality, while coordinated with others, has its own organization. With the current exploration of bodily-visual turn extensions, we hope to contribute to a growing understanding of how these different modes of organization are managed concurrently and in concert by interactants in carrying out their everyday social actions.

  9. Determination of {sup 236}U in environmental samples by single extraction chromatography coupled to triple-quadrupole inductively coupled plasma-mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Guosheng [Department of Radiation Chemistry, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki, Aomori, 036-8564 (Japan); Division of Nuclear Technology and Applications, Institute of High Energy Physics, Chinese Academy of Sciences (China); Beijing Engineering Research Center of Radiographic Techniques and Equipment, Beijing, 100049 (China); Tazoe, Hirofumi [Department of Radiation Chemistry, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki, Aomori, 036-8564 (Japan); Yamada, Masatoshi, E-mail: myamada@hirosaki-u.ac.jp [Department of Radiation Chemistry, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki, Aomori, 036-8564 (Japan)

    2016-11-09

    In order to measure trace {sup 236}U and {sup 236}U/{sup 238}U in environmental samples with a high matrix effect, a novel and simple method was developed that makes the digestion and purification procedures compatible with advanced triple-quadrupole inductively coupled plasma-mass spectrometry. A total dissolution of sample with HF + HNO{sub 3} + HClO{sub 4} was followed by chromatographic separation with a single resin column containing normal type DGA resin (N,N,N′,N’-tetra-n-octyldiglycolamide) as the extractant system. The analytical accuracy and precision of {sup 236}U/{sup 238}U ratios, measured as {sup 236}U{sup 16}O{sup +}/{sup 238}U{sup 16}O{sup +}, were examined by using the reference materials IAEA-135, IAEA-385, IAEA-447, and JSAC 0471. The low method detection limit (3.50 × 10{sup −6} Bq kg{sup −1}) makes it possible to perform routine monitoring of environmental {sup 236}U due to global fallout combined with the Fukushima Daiichi Nuclear Power Plant accident fallout (>10{sup −5} Bq kg{sup −1}). Finally, the developed method was successfully applied to measure {sup 236}U/{sup 238}U ratios and {sup 236}U activities in soil samples contaminated by the accident. The low {sup 236}U/{sup 238}U atom ratios ((1.50–13.5) × 10{sup −8}) and {sup 236}U activities ((2.25–14.1) × 10{sup −2} mBq kg{sup −1}) indicate {sup 236}U contamination was mainly derived from global fallout in the examined samples. - Highlights: • A simple {sup 236}U/{sup 238}U analytical method has been developed. • The separation required just one DGA column chromatography. • {sup 236}U/{sup 238}U atom ratios in soil were measured by ICP-MS/MS. • {sup 236}U/{sup 238}U atom ratios of (1.50–13.5) × 10{sup −8} were observed in Japanese samples. • {sup 236}U activities of (2.25–14.1) × 10{sup −2} mBq kg{sup −1} were found in Japanese samples.

  10. Turning points in the history of mathematics

    CERN Document Server

    Grant, Hardy

    2015-01-01

    This book explores some of the major turning points in the history of mathematics, ranging from ancient Greece to the present, demonstrating the drama that has often been a part of its evolution. Studying these breakthroughs, transitions, and revolutions, their stumbling-blocks and their triumphs, can help illuminate the importance of the history of mathematics for its teaching, learning, and appreciation. Some of the turning points considered are the rise of the axiomatic method (most famously in Euclid), and the subsequent major changes in it (for example, by David Hilbert); the “wedding,” via analytic geometry, of algebra and geometry; the “taming” of the infinitely small and the infinitely large; the passages from algebra to algebras, from geometry to geometries, and from arithmetic to arithmetics; and the revolutions in the late nineteenth and early twentieth centuries that resulted from Georg Cantor’s creation of transfinite set theory. The origin of each turning point is discussed, along with...

  11. First turn around strategy for RHIC

    International Nuclear Information System (INIS)

    Milutinovic, J.; Ruggiero, A.G.

    1991-01-01

    The authors present a strategy for achieving the so-called first turn around in RHIC. The strategy is based on the same method proposed to correct a distorted closed orbit in RHIC, i.e. on a generalization of the local three-bump method. They found out that the method is very effective in passing the beam through a non-ideal, insufficiently known, machine. The perturbed lattice was generated by the code PATRIS, which was also adapted to control the newly developed software. In ten distributions of errors the software was capable of passing the beam through in 2-3 injection attempts, at full sextupole strength. It was also determined that once the beam makes the first turn around and all the correctors are energized, it stays in the machine for at least several hundred turns

  12. A single supplement of a standardised bilberry (Vaccinium myrtillus L.) extract (36 % wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes controlled by diet and lifestyle

    DEFF Research Database (Denmark)

    Hoggard, Nigel; Cruickshank, Morven; Moar, Kim-Marie

    2013-01-01

    and thus postprandial glycaemia. In addition, berries have been reported to alter incretins as well as to have antioxidant and anti-inflammatory properties that may also affect postprandial glycaemia. The present study investigated the acute effect of a standardised bilberry extract on glucose metabolism...... in T2D. Male volunteers with T2D (n 8; BMI 30 (sd 4) kg/m(2)) controlling their diabetes by diet and lifestyle alone were given a single oral capsule of either 0·47 g standardised bilberry extract (36 % (w/w) anthocyanins) which equates to about 50 g of fresh bilberries or placebo followed...... by a polysaccharide drink (equivalent to 75 g glucose) in a double-blinded cross-over intervention with a 2-week washout period. The ingestion of the bilberry extract resulted in a significant decrease in the incremental AUC for both glucose (P = 0·003) and insulin (P = 0·03) compared with the placebo...

  13. Increased type I collagen content and DNA binding activity of a single-stranded, cytosine-rich sequence in the high-salt buffer protein extract of the copper-deficient rat heart.

    Science.gov (United States)

    Zeng, Huawei; Saari, Jack T

    2004-11-01

    Dietary copper (Cu) deficiency not only causes a hypertrophic cardiomyopathy but also increases cancer risk in rodent models. However, a possible alteration in gene expression has not been fully examined. The present study was undertaken to determine the effect of Cu deficiency on protein profiles in rat heart tissue. Male Sprague-Dawley rats were fed diets that were either a Cu-adequate diet (6.0 microg Cu/g diet, n = 6) or a Cu-deficient diet (0.3 microg Cu/g diet, n = 6) for 5 weeks. The high-salt buffer (HSB) protein extract from heart tissue of Cu-deficient, but not Cu-adequate rats showed a 132 kDa protein band by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis. This protein band stained pink with Coomassie Blue, suggesting the presence of collagens or other proline-rich proteins. Dot immunoblotting demonstrated that total type I collagen was increased by 110% in HSB protein extract from Cu-deficient, relative to Cu-adequate, rats. Liquid chromatography with mass spectrometry analysis indicated that the 132 kDa protein band contained a collagen alpha (I) chain precursor as well as a leucine-rich protein 130 (LRP130) in HSB protein extract from Cu-deficient but not Cu-adequate rats. A gel shift assay showed that HSB protein extract from Cu-deficient rats bound to a single-stranded cytosine-rich DNA with higher affinity than the extract of Cu-adequate rats, similar to reports of an increase in LRP130 single-stranded DNA binding activity in several types of tumor cells. Collectively, these results not only suggest an additional feature of altered collagen metabolism with Cu deficiency but also demonstrate for the first time an increase in single-stranded cytosine-rich DNA binding in Cu-deficient rat heart.

  14. CONNECTION OF TURN AHEAD AND TURN BACK WITH MOTORIC ABILITIES OF THE FIFTH GRADE STUDENTS

    Directory of Open Access Journals (Sweden)

    Jovica Petković

    2006-06-01

    Full Text Available The research is done for the purpose of determination and defining of the level of connection between some motoric abilities with success in realization of programmed contents from the area of gymnastics (turn ahead and turn back. The research is done on the sample of fifty one students from the fifth grade of Elementary School, on ten motoric tests and on two specific motoric assignments – turn ahead and turn back. The results of this research clearly point that there exist the multitude of statistically important coefficients of correlation between treated motoric abilities and applied motoric assignments.

  15. Seismic interferometry-turning noise into signal

    NARCIS (Netherlands)

    Curtis, A.; Gerstoft, P.; Sato, H.; Snieder, R.; Wapenaar, C.P.A.

    2006-01-01

    Turning noise into useful data—every geophysicist's dream? And now it seems possible. The field of seismic interferometry has at its foundation a shift in the way we think about the parts of the signal that are currently filtered out of most analyses—complicated seismic codas (the multiply scattered

  16. Business Intelligence: Turning Knowledge into Power

    Science.gov (United States)

    Endsley, Krista

    2009-01-01

    Today, many school districts are turning to business intelligence tools to retrieve, organize, and share knowledge for faster analysis and more effective, guided decision making. Business intelligence (BI) tools are the technologies and applications that gather and report information to help an organization's leaders make better decisions. BI…

  17. Speed docking: reducing truck turn times

    NARCIS (Netherlands)

    Ploos van Amstel, W.

    2013-01-01

    Truck turn times in FMCG supply chain are unreliable. The Dutch ‘Speed Docking’ project in gave clear evidence to this. The result is too many trucks and drivers. FMCG producers, together with logistics service providers and customers, can realise improvements with the use of mobile communication,

  18. The dynamic turn in quantum logic

    NARCIS (Netherlands)

    Baltag, Alexandru; Smets, Sonja

    In this paper we show how ideas coming from two areas of research in logic can reinforce each other. The first such line of inquiry concerns the "dynamic turn" in logic and especially the formalisms inspired by Propositional Dynamic Logic (PDL); while the second line concerns research into the

  19. Strategy in Generative Planning of Turning Processes

    NARCIS (Netherlands)

    van Houten, Frederikus J.A.M.; Kals, H.J.J.

    1986-01-01

    This paper reports on the process and operations planning system ROUND and the strategies which underlie the decision making processes in the planning of turning operations. At first, an outline is given about the environment for which generative systems like ROUND are being developed. The

  20. Train turn restrictions and line plan performance

    DEFF Research Database (Denmark)

    Burggraeve, Sofie; Bull, Simon Henry; Lusby, Richard Martin

    In this paper we study the impact of the `turn conditions' in end stations on the performance of a line plan. If trains have to turn on their platform in an end station, the yoccupy the platform for several minutes. A more preferred option, from a timetabling point of view, would be that a train...... disappears from the platform in its end station after dwelling and only appears again when departing for a subsequent trip. In this case, the train will not interfere with other trains that dwell on the platform during the time between these events. However, this option is only possible if the train can stay...... in a exible and large enough shunt. Starting from a given line plan, we compare two timetables, one where trains have to turn on their platform and one where trains can turn in a shunt. We evaluate the impact on the performance of the line plan by its feasibility for timetabling,the minimum overall buffer...

  1. Silicon Carbide Emitter Turn-Off Thyristor

    Directory of Open Access Journals (Sweden)

    Jun Wang

    2008-01-01

    Full Text Available A novel MOS-controlled SiC thyristor device, the SiC emitter turn-off thyristor (ETO is a promising technology for future high-voltage switching applications because it integrates the excellent current conduction capability of a SiC thyristor with a simple MOS-control interface. Through unity-gain turn-off, the SiC ETO also achieves excellent Safe Operation Area (SOA and faster switching speeds than silicon ETOs. The world's first 4.5-kV SiC ETO prototype shows a forward voltage drop of 4.26 V at 26.5 A/cm2 current density at room and elevated temperatures. Tested in an inductive circuit with a 2.5 kV DC link voltage and a 9.56-A load current, the SiC ETO shows a fast turn-off time of 1.63 microseconds and a low 9.88 mJ turn-off energy. The low switching loss indicates that the SiC ETO could operate at about 4 kHz if 100 W/cm2 conduction and the 100 W/cm2 turn-off losses can be removed by the thermal management system. This frequency capability is about 4 times higher than 4.5-kV-class silicon power devices. The preliminary demonstration shows that the SiC ETO is a promising candidate for high-frequency, high-voltage power conversion applications, and additional developments to optimize the device for higher voltage (>5 kV and higher frequency (10 kHz are needed.

  2. Research of remote control system in turn by turn timing system

    International Nuclear Information System (INIS)

    Zhan Zhifeng; Xiao Yanguo; Ma Kui; Yin Zejie; Wu Xiaoyi

    2003-01-01

    In this paper, we introduce a remote control system which is used in a frequency dividing and time-delay module. This control system is based on client/server architecture, and RS232 serial communication protocol. This control system is used in timing system of NSRL turn by turn beam position monitor

  3. Immediate Effects of Clock-Turn Strategy on the Pattern and Performance of Narrow Turning in Persons With Parkinson Disease.

    Science.gov (United States)

    Yang, Wen-Chieh; Hsu, Wei-Li; Wu, Ruey-Meei; Lin, Kwan-Hwa

    2016-10-01

    Turning difficulty is common in people with Parkinson disease (PD). The clock-turn strategy is a cognitive movement strategy to improve turning performance in people with PD despite its effects are unverified. Therefore, this study aimed to investigate the effects of the clock-turn strategy on the pattern of turning steps, turning performance, and freezing of gait during a narrow turning, and how these effects were influenced by concurrent performance of a cognitive task (dual task). Twenty-five people with PD were randomly assigned to the clock-turn or usual-turn group. Participants performed the Timed Up and Go test with and without concurrent cognitive task during the medication OFF period. The clock-turn group performed the Timed Up and Go test using the clock-turn strategy, whereas participants in the usual-turn group performed in their usual manner. Measurements were taken during the 180° turn of the Timed Up and Go test. The pattern of turning steps was evaluated by step time variability and step time asymmetry. Turning performance was evaluated by turning time and number of turning steps. The number and duration of freezing of gait were calculated by video review. The clock-turn group had lower step time variability and step time asymmetry than the usual-turn group. Furthermore, the clock-turn group turned faster with fewer freezing of gait episodes than the usual-turn group. Dual task increased the step time variability and step time asymmetry in both groups but did not affect turning performance and freezing severity. The clock-turn strategy reduces turning time and freezing of gait during turning, probably by lowering step time variability and asymmetry. Dual task compromises the effects of the clock-turn strategy, suggesting a competition for attentional resources.Video Abstract available for more insights from the authors (see Supplemental Digital Content 1, http://links.lww.com/JNPT/A141).

  4. Multiple sensor monitoring in nickel alloy turning for tool wear assessment via sensor fusion

    OpenAIRE

    Segreto, T.; Simeone, A.; Teti, R.

    2013-01-01

    A multiple sensor monitoring system comprising cutting force, acoustic emission and vibration sensing units was employed for tool state assessment during turning of Inconel 718 nickel alloy. Feature extraction was realised by processing the detected sensor signals in order to reduce the high dimensionality of the sensorial data. The extracted features were fused to realise a sensor fusion methodology based on neural network pattern recognition for decision making on tool wear condition.

  5. A method for simultaneous linear optics and coupling correction for storage rings with turn-by-turn beam position monitor data

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Xi; Huang, Xiaobiao

    2016-08-01

    We propose a method to simultaneously correct linear optics errors and linear coupling for storage rings using turn-by-turn (TbT) beam position monitor (BPM) data. The independent component analysis (ICA) method is used to isolate the betatron normal modes from the measured TbT BPM data. The betatron amplitudes and phase advances of the projections of the normal modes on the horizontal and vertical planes are then extracted, which, combined with dispersion measurement, are used to fit the lattice model. The fitting results are used for lattice correction. The method has been successfully demonstrated on the NSLS-II storage ring.

  6. A method for simultaneous linear optics and coupling correction for storage rings with turn-by-turn beam position monitor data

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Xi [Brookhaven National Laboratory, Upton, Long Island, NY 11973 (United States); Huang, Xiaobiao, E-mail: xiahuang@slac.stanford.edu [SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States)

    2016-08-21

    We propose a method to simultaneously correct linear optics errors and linear coupling for storage rings using turn-by-turn (TbT) beam position monitor (BPM) data. The independent component analysis (ICA) method is used to isolate the betatron normal modes from the measured TbT BPM data. The betatron amplitudes and phase advances of the projections of the normal modes on the horizontal and vertical planes are then extracted, which, combined with dispersion measurement, are used to fit the lattice model. The fitting results are used for lattice correction. The method has been successfully demonstrated on the NSLS-II storage ring.

  7. A method for simultaneous linear optics and coupling correction for storage rings with turn-by-turn beam position monitor data

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Xi [Brookhaven National Lab. (BNL), Upton, NY (United States); Huang, Xiaobiao [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2016-08-01

    We propose a method to simultaneously correct linear optics errors and linear coupling for storage rings using turn-by-turn (TbT) beam position monitor (BPM) data. The independent component analysis (ICA) method is used to isolate the betatron normal modes from the measured TbT BPM data. The betatron amplitudes and phase advances of the projections of the normal modes on the horizontal and vertical planes are then extracted, which, combined with dispersion measurement, are used to fit the lattice model. Furthermore, the fitting results are used for lattice correction. Our method has been successfully demonstrated on the NSLS-II storage ring.

  8. Serogrouping single colonies of beta-hemolytic streptococci from primary throat culture plates with nitrous acid extraction and Phadebact streptococcal reagents.

    Science.gov (United States)

    Slifkin, M; Interval, G

    1980-10-01

    The serogrouping of isolated beta-hemolytic streptococcal colonies from throat cultures by a micronitrous acid extraction method employing Phadebact Streptotoccus Test reagents was compared with results obtained with the direct-plate Phadebact procedure and the autoclave and Streptomyces albus enzyme-lysozyme extraction methods. These data were compared with those from the Lancefield grouping obtained with a capillary precipitin test. The micronitrous acid extraction method was modified to yield an uncomplicated method that provides specific coagglutination responses from one beta-hemolytic streptococcal colony that may be collected from a primary blood agar plate either on the end of an applicator stick or from a sweep of an inoculating loop from mixed growth.

  9. Bank-to-turn control technology survey for homing missiles

    Science.gov (United States)

    Riedel, F. W.

    1980-01-01

    The potential advantages of bank-to-turn control are summarized. Recent and current programs actively investigating bank-to-turn steering are reviewed and critical technology areas concerned with bank-to-turn control are assessed.

  10. Turning the Appliance Market Around towards A++

    DEFF Research Database (Denmark)

    Nørgaard, Jørgen; Brange, Birgitte; Guldbrandsen, Tom

    2007-01-01

    in the course of a few years. Where models C, D, E earlier dominated the market, the A, A+ and A++, came to dominate as the standard models in stock. Consequently, their prices dropped significantly. The theory of a rational market behavior is based on some assumptions, one being that full information...... energy efficient model within their specification, and 4) in the website are also listed the shops, where consumers can get the appliances at lowest prices. The latter was the most innovative and maybe also the most effective measure in the package. Results showed up as a permanent U-turn of the market...... is available to all actors. The website identifying to the consumers the shops with the lowest priced efficient models was a step in that direction, and the result did not fail to turn up....

  11. Measurement of tool forces in diamond turning

    Energy Technology Data Exchange (ETDEWEB)

    Drescher, J.; Dow, T.A.

    1988-12-01

    A dynamometer has been designed and built to measure forces in diamond turning. The design includes a 3-component, piezoelectric transducer. Initial experiments with this dynamometer system included verification of its predicted dynamic characteristics as well as a detailed study of cutting parameters. Many cutting experiments have been conducted on OFHC Copper and 6061-T6 Aluminum. Tests have involved investigation of velocity effects, and the effects of depth and feedrate on tool forces. Velocity has been determined to have negligible effects between 4 and 21 m/s. Forces generally increase with increasing depth of cut. Increasing feedrate does not necessarily lead to higher forces. Results suggest that a simple model may not be sufficient to describe the forces produced in the diamond turning process.

  12. When attempts at robbing prey turn fatal

    Science.gov (United States)

    Dejean, Alain; Corbara, Bruno; Azémar, Frédéric; Carpenter, James M.

    2012-07-01

    Because group-hunting arboreal ants spread-eagle insect prey for a long time before retrieving them, these prey can be coveted by predatory flying insects. Yet, attempting to rob these prey is risky if the ant species is also an effective predator. Here, we show that trying to rob prey from Azteca andreae workers is a fatal error as 268 out of 276 potential cleptobionts (97.1 %) were captured in turn. The ant workers hunt in a group and use the "Velcro®" principle to cling firmly to the leaves of their host tree, permitting them to capture very large prey. Exceptions were one social wasp, plus some Trigona spp. workers and flies that landed directly on the prey and were able to take off immediately when attacked. We conclude that in this situation, previously captured prey attract potential cleptobionts that are captured in turn in most of the cases.

  13. Abrasive Waterjet (AWJ) Titanium Tangental Turning Evaluation

    Czech Academy of Sciences Publication Activity Database

    Hloch, Sergej; Hlaváček, Petr; Vasilko, K.; Cárach, J.; Samardžič, I.; Kozak, D.; Ščučka, Jiří; Klich, Jiří; Klichová, Dagmar

    2014-01-01

    Roč. 53, č. 4 (2014), s. 537-540 ISSN 0543-5846 R&D Projects: GA MŠk ED2.1.00/03.0082 Institutional support: RVO:68145535 Keywords : titanium * abrasive waterjet turning * traverse speed Subject RIV: JQ - Machines ; Tools Impact factor: 0.959, year: 2014 http://public.carnet.hr/metalurg/Metalurgija/2014_vol_53/No_4/MET_53_4_537-540_Hloch.pdf

  14. Turning customer satisfaction measurements into action

    OpenAIRE

    Lervik-Olsen, Line; Witell, Lars; Gustafsson, Anders

    2014-01-01

    This is the authors’ final, accepted and refereed manuscript to the article. Publisher’s version available at http://dx.doi.org/10.1108/JOSM-01-2014-0025 Purpose – The purpose of this paper is to contribute to the literature on customer orientation by developing and empirically testing a model that attempts to explain the elements that constitute customer orientation and that, in turn, influence customer satisfaction. In particular, this study focuses on how service firms design, ...

  15. Turning points in climate change adaptation

    Directory of Open Access Journals (Sweden)

    Saskia Elisabeth. Werners

    2015-12-01

    Full Text Available Concerned decision makers increasingly pose questions as to whether current management practices are able to cope with climate change and increased climate variability. This signifies a shift in the framing of climate change from asking what its potential impacts are to asking whether it induces policy failure and unacceptable change. In this paper, we explore the background, feasibility, and consequences of this new framing. We focus on the specific situation in which a social-political threshold of concern is likely to be exceeded as a result of climate change, requiring consideration of alternative strategies. Action is imperative when such a situation is conceivable, and at this point climate change becomes particularly relevant to decision makers. We call this situation an "adaptation turning point." The assessment of adaptation turning points converts uncertainty surrounding the extent of a climate impact into a time range over which it is likely that specific thresholds will be exceeded. This can then be used to take adaptive action. Despite the difficulty in identifying adaptation turning points and the relative newness of the approach, experience so far suggests that the assessment generates a meaningful dialogue between stakeholders and scientists. Discussion revolves around the amount of change that is acceptable; how likely it is that unacceptable, or more favorable, conditions will be reached; and the adaptation pathways that need to be considered under these circumstances. Defining and renegotiating policy objectives under climate change are important topics in the governance of adaptation.

  16. FCC-hh turn-around cycle

    CERN Document Server

    Alemany Fernandez, Reyes; Bartmann, Wolfgang; Buffat, Xavier; Niemi, Arto; Schulte, Daniel; Solfaroli Camillocci, Matteo; Stoel, Linda

    2016-01-01

    The turn-around cycle time of a collider is defined as the time spent between the end of stable beams and the start of the next stable beams period, and its calculation is of fundamental importance. On one side it is a crucial ingredient for the computation of the optimal time spent in luminosity production, which defines the integrated luminosity per fill or store. On the other side, combined with the availability and reliability of the machine, it allows to perform a detailed breakdown of the operational performance of the collider over an operational season, i.e. percentage of time in stable beams and beam in the machine with respect to down time. This paper presents a preliminary operational cycle definition for the hadron-hadron Future Circular Collider, as a base line for estimating the corresponding turn-around time. The cycle definition is based on the Large Hadron Collider (LHC) operational cycle. Two turn-around times are presented, the theoretical one and a more realistic one based on the LHC exper...

  17. Beam Optics Measurements Through Turn by Turn Beam Position Data in the SLS

    CERN Document Server

    Zisopoulos, P; Streun, A; Ziemann, v

    2013-01-01

    Refined Fourier analysis of turn-by-turn (TBT) transverse position data measurements can be used for determining several beam properties of a ring, such as transverse tunes, optics functions, phases, chromatic properties and coupling. In particular, the Numerical Analysis of Fundamental Frequencies (NAFF) algorithm is used to analyse TBT data from the Swiss Light Source (SLS) storage ring in order to estimate on and off-momentum beam characteristics. Of particular interest is the potential of using the full position information within one turn in order to measure beam optics properties.

  18. Oral health-related quality of life changes after placement of immediately loaded single implants in healed alveolar ridges or extraction sockets: a 5-year prospective follow-up study.

    Science.gov (United States)

    Raes, Stefanie; Raes, Filiep; Cooper, Lyndon; Giner Tarrida, Luis; Vervaeke, Stijn; Cosyn, Jan; De Bruyn, Hugo

    2017-06-01

    The impact of single implants on oral health-related quality of life (OHRQoL) is scarcely investigated, especially when combined with immediate placement and loading in extraction sockets. The aim was to describe prospectively the changes of OHRQoL with single implants placed in the esthetic zone in healed ridges or in extraction sockets after 5 years. Ninety-six patients, enrolled at three clinical centers, received 102 single implants placed in a healed ridge (n = 54 implants/50 patients) or in extraction sockets (n = 48 implants/46 patients). Implants were immediately provisionalized, and permanent crowns were cemented after 12 weeks. Oral health impact profile questionnaires (OHIP-14) were completed before surgery, after 1 (provisional crown), 6 (permanent crown), 12 and 60 months, respectively. The overall OHIP-14 score pertains to seven domains with two items each and was assessed on a Likert scale of 0-4 (0 = never and 4 = very often). The evolution of the total OHIP-14 score and changes within all OHIP domains over time and between groups were assessed with a linear mixed-effect model analysis. After 5 years, overall implant survival was 98%. The total OHIP-14 score for both groups combined decreased from 0.50 at baseline to 0.17 at 6 months (P < 0.001), indicative of improvement. For both groups, this remained stable up to 5 years (P = 0.41). However, after 5 years, the total OHIP-14 score revealed a statistically significantly higher improvement in the healed group compared with the extraction group (P = 0.027). Missing a single tooth in the maxillary esthetic zone leads to limited OHRQoL problems as reflected by a low overall OHIP score. However, OHRQoL improves less in the extraction group, reflecting that replacing a missing tooth is perceived as more beneficial than replacing a present tooth. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  19. Periodontal ligament injection versus routine local infiltration for nonsurgical single posterior maxillary permanent tooth extraction: comparative double-blinded randomized clinical study

    Directory of Open Access Journals (Sweden)

    Al-Shayyab MH

    2017-10-01

    Full Text Available Mohammad H Al-Shayyab Department of Oral and Maxillofacial Surgery, Oral Medicine and Periodontology, School of Dentistry, University of Jordan, Amman, Jordan Aim: The aim of this study was to evaluate the efficacy of, and patients’ subjective responses to, periodontal ligament (PDL anesthetic injection compared to traditional local-anesthetic infiltration injection for the nonsurgical extraction of one posterior maxillary permanent tooth. Materials and methods: All patients scheduled for nonsurgical symmetrical maxillary posterior permanent tooth extraction in the Department of Oral and Maxillofacial Surgery at the University of Jordan Hospital, Amman, Jordan over a 7-month period were invited to participate in this prospective randomized double-blinded split-mouth study. Every patient received the recommended volume of 2% lidocaine with 1:100,000 epinephrine for PDL injection on the experimental side and for local infiltration on the control side. A visual analog scale (VAS and verbal rating scale (VRS were used to describe pain felt during injection and extraction, respectively. Statistical significance was based on probability values <0.05 and measured using Χ2 and Student t-tests and nonparametric Mann–Whitney and Kruskal–Wallis tests. Results: Of the 73 patients eligible for this study, 55 met the inclusion criteria: 32 males and 23 females, with a mean age of 34.87±14.93 years. Differences in VAS scores and VRS data between the two techniques were statistically significant (P<0.001 and in favor of the infiltration injection. Conclusion: The PDL injection may not be the alternative anesthetic technique of choice to routine local infiltration for the nonsurgical extraction of one posterior maxillary permanent tooth. Keywords: PDL injection, infiltration, anesthesia, extraction

  20. Toward Real-Time Automated Detection of Turns during Gait Using Wearable Inertial Measurement Units

    Directory of Open Access Journals (Sweden)

    Domen Novak

    2014-10-01

    Full Text Available Previous studies have presented algorithms for detection of turns during gait using wearable sensors, but those algorithms were not built for real-time use. This paper therefore investigates the optimal approach for real-time detection of planned turns during gait using wearable inertial measurement units. Several different sensor positions (head, back and legs and three different detection criteria (orientation, angular velocity and both are compared with regard to their ability to correctly detect turn onset. Furthermore, the different sensor positions are compared with regard to their ability to predict the turn direction and amplitude. The evaluation was performed on ten healthy subjects who performed left/right turns at three amplitudes (22, 45 and 90 degrees. Results showed that turn onset can be most accurately detected with sensors on the back and using a combination of orientation and angular velocity. The same setup also gives the best prediction of turn direction and amplitude. Preliminary measurements with a single amputee were also performed and highlighted important differences such as slower turning that need to be taken into account.

  1. Assessing lexical, syntactic, and conceptual turn-by-turn alignment in conversations involving conflict and deception

    DEFF Research Database (Denmark)

    Duran, Nicholas; Fusaroli, Riccardo; Paxton, Alexandra

    2015-01-01

    -level linguistic alignment, we turn to a unique conversational context: one in which participants disagree or agree with each other about contentious sociopolitical topics, with the added element of one partner secretly taking a "devil's advocate" position. Our findings reveal that high-level intentional factors......Our goal is to present a novel systematic approach for automatically assessing conversational alignment across turn-by-turn exchanges, examining linguistic behavior at increasing levels of abstractness through lexical, syntactic, and conceptual similarity. Using the latest advances in Python......-based NLP tools, the procedure begins by taking conversational partners' turns and converting each into a lemmatized sequence of words, assigning part-of-speech tags and computing high-dimensional semantic vectors per each utterance. Words and part-of-speech tags are further sequenced into n-g! rams...

  2. A 5-day method for determination of soluble silicon concentrations in nonliquid fertilizer materials using a sodium carbonate-ammonium nitrate extractant followed by visible spectroscopy with heteropoly blue analysis: single-laboratory validation.

    Science.gov (United States)

    Sebastian, Dennis; Rodrigues, Hugh; Kinsey, Charles; Korndörfer, Gaspar; Pereira, Hamilton; Buck, Guilherme; Datnoff, Lawrence; Miranda, Stephen; Provance-Bowley, Mary

    2013-01-01

    A 5-day method for determining the soluble silicon (Si) concentrations in nonliquid fertilizer products was developed using a sodium carbonate (Na2CO3)-ammonium nitrate (NH4NO3) extractant followed by visible spectroscopy with heteropoly blue analysis at 660 nm. The 5-Day Na2CO3-NH4NO3 Soluble Si Extraction Method can be applied to quantify the plant-available Si in solid fertilizer products at levels ranging from 0.2 to 8.4% Si with an LOD of 0.06%, and LOQ of 0.20%. This Si extraction method for fertilizers correlates well with plant uptake of Si (r2 = 0.96 for a range of solid fertilizers) and is applicable to solid Si fertilizer products including blended products and beneficial substances. Fertilizer materials can be processed as received using commercially available laboratory chemicals and materials at ambient laboratory temperatures. The single-laboratory validation of the 5-Day Na2CO3-NH4NO3 Soluble Si Extraction Method has been approved by The Association of American Plant Food Control Officials for testing nonliquid Si fertilizer products.

  3. Turn-by-Turn Analysis of Proton and Gold Beams at Injection in the AGS Booster

    International Nuclear Information System (INIS)

    Gardner, C.; Ahrens, L.; Williams, N.

    1999-01-01

    In this paper the authors describe the latest version of a program they have used for several years to acquire and analyze turn-by-turn data from pick-up electrodes in the AGS Booster during injection. The program determines several parameters of the injected beam including the tunes and the position and angle of the incoming beam. Examples are given for both proton and gold injection

  4. CERN PS Optical Properties Measured with Turn-By-Turn Orbit Data

    CERN Document Server

    Bach, T; Giovannozzi, M; Hernalsteens, C; Lachaize, A; Sterbini, G; Tom´as, R; Wasef, R

    2013-01-01

    The performance of the CERN Proton Synchrotron (PS) has been constantly increasing over the years both in terms of beam parameters (intensity and brightness) and beam manipulations (transverse and longitudinal splitting). This implies a very good knowledge of the linear and non-linear model of the ring. In this paper we report on a detailed campaign of beam measurements based on turn-by-turn orbit data aimed at measuring the optics in several conditions as well as the resonance driving terms.

  5. Hummingbirds control turning velocity using body orientation and turning radius using asymmetrical wingbeat kinematics.

    Science.gov (United States)

    Read, Tyson J G; Segre, Paolo S; Middleton, Kevin M; Altshuler, Douglas L

    2016-03-01

    Turning in flight requires reorientation of force, which birds, bats and insects accomplish either by shifting body position and total force in concert or by using left-right asymmetries in wingbeat kinematics. Although both mechanisms have been observed in multiple species, it is currently unknown how each is used to control changes in trajectory. We addressed this problem by measuring body and wingbeat kinematics as hummingbirds tracked a revolving feeder, and estimating aerodynamic forces using a quasi-steady model. During arcing turns, hummingbirds symmetrically banked the stroke plane of both wings, and the body, into turns, supporting a body-dependent mechanism. However, several wingbeat asymmetries were present during turning, including a higher and flatter outer wingtip path and a lower more deviated inner wingtip path. A quasi-steady analysis of arcing turns performed with different trajectories revealed that changes in radius were associated with asymmetrical kinematics and forces, and changes in velocity were associated with symmetrical kinematics and forces. Collectively, our results indicate that both body-dependent and -independent force orientation mechanisms are available to hummingbirds, and that these kinematic strategies are used to meet the separate aerodynamic challenges posed by changes in velocity and turning radius. © 2016 The Author(s).

  6. Mimicry by asx- and ST-turns of the four main types of β-turn in proteins

    OpenAIRE

    Duddy, William J.; Nissink, J. Willem M.; Allen, Frank H.; Milner-White, E. James

    2004-01-01

    Hydrogen-bonded β-turns in proteins occur in four categories: type I (the most common), type II, type II’, and type I’. Asx-turns resemble β-turns, in that both have an NH. . .OC hydrogen bond forming a ring of 10 atoms. Serine and threonine side chains also commonly form hydrogen-bonded turns, here called ST-turns. Asx-turns and ST-turns can be categorized into four classes, based on side chain rotamers and the conformation of the central turn residue, which are geometrically equivalent to t...

  7. Efficacy of Topical Coriandrum sativum Extract on Treatment of Infants with Diaper Dermatitis: A Single Blinded Non-Randomised Controlled Trial.

    Science.gov (United States)

    Dastgheib, Ladan; Pishva, Narjes; Saki, Nasrin; Khabnadideh, Soghra; Kardeh, Bahareh; Torabi, Fatemeh; Arabnia, Shahram; Heiran, Alireza

    2017-08-01

    Diaper dermatitis is a common disorder. Coriandrum sativum is a herbal remedy with anti-inflammatory, analgesic, anti-microbial and anti-oxidant activities effects. In this non randomised clinical trial which was performed on 58 infants with diaper dermatitis referred to Faghihi Hospital, Shiraz University of Medical Sciences, the efficacy and safety of topical Coriandrum extract cream is compared with hydrocortisone ointment. Coriandrum sativum extract cream was administered for 37 (intervention group) and hydrocortisone 1% ointment for 21 (control group) patients. Patients were examined on days 3 and 10. Chi-square test was applied for statistical analysis. The results demonstrated a statistically significant difference in the cure rate (20 (54.1%) for the intervention group versus 19 (90.5%) for the control group) ( P -value = 0.005) and side effects (10 (27%) for the intervention group versus 0 (0%) for control group) ( P -value = 0.009) both in favor of hydrocortisone. This trial failed to confirm the efficacy of Coriandrum sativum in the treatment of diaper dermatitis; however, it seems that if soothing compounds are used in combination with Coriandrum sativum to reduce the mild irritation, Coriandrum extract can be an alternative treatment for diaper dermatitis.

  8. Fluorescence turn on by cholate aggregates.

    Science.gov (United States)

    Baldridge, Anthony; Amador, Adrian; Tolbert, Laren M

    2011-04-05

    Bile salts, including sodium cholate (NaCh), are amphiphilic molecules with a concave hydrophilic side and a convex hydrophobic side. By forming aggregates in aqueous solution, these natural surfactants fulfill vital biological roles in the solubilization of cholesterol, lipids, and fat-soluble vitamins and thus are involved in the transport and absorption of important biological molecules. Following our success with the encapsulation of fluorescent protein chromophore (FP) analogs by synthetic hydrophobic and hydrophilic hosts, based upon substitution patterns, we now report the binding and turn on of other analogs by bile salt aggregates, observations which may lead to new tools for studying trafficking in these important systems.

  9. Turning a page of Agency history

    International Nuclear Information System (INIS)

    1969-01-01

    Recent developments, and especially the new and critical interest of developing countries, have helped to mark the turning of a page in the Agency's history. If the present situation in the economics of nuclear power does not change there is a danger that developing countries will lag further and further behind the advanced countries in its use. Shortage of resources impose a brake on Agency efforts to promote benefits of nuclear techniques, especially by technical assistance. These were some of the points made by Dr. Sigvard Eklund, the Director General, when he presented the Agency's annual report to the Economic and Social Council (ECOSOC) in July. (author)

  10. The Septa for LEIR Extraction and PS Injection

    CERN Document Server

    Borburgh, J; Masson, T; Prost, A

    2006-01-01

    The Low Energy Ion Ring (LEIR) is part of the CERN LHC injector chain for ions. The LEIR extraction uses a pulsed magnetic septum, clamped around a metallic vacuum chamber. Apart from separating the ultra high vacuum in the LEIR ring from the less good vacuum in the transfer line to the PS this chamber also serves as magnetic screen and retains the septum conductor in place. The PS ion injection septum consists of a pulsed laminated magnet under vacuum, featuring a single-turn water cooled coil and a remote positioning system. The design, the construction and the commissioning of both septa are described.

  11. Protective effects of pulmonary epithelial lining fluid on oxidative stress and DNA single-strand breaks caused by ultrafine carbon black, ferrous sulphate and organic extract of diesel exhaust particles

    Energy Technology Data Exchange (ETDEWEB)

    Chuang, Hsiao-Chi [School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan (China); Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan (China); Cheng, Yi-Ling; Lei, Yu-Chen [Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan (China); Chang, Hui-Hsien [Institute of Environmental Health, College of Public Health, National Taiwan University, Taipei, Taiwan (China); Cheng, Tsun-Jen, E-mail: tcheng@ntu.edu.tw [Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan (China); Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan (China)

    2013-02-01

    Pulmonary epithelial lining fluid (ELF) is the first substance to make contact with inhaled particulate matter (PM) and interacts chemically with PM components. The objective of this study was to determine the role of ELF in oxidative stress, DNA damage and the production of proinflammatory cytokines following physicochemical exposure to PM. Ultrafine carbon black (ufCB, 15 nm; a model carbonaceous core), ferrous sulphate (FeSO{sub 4}; a model transition metal) and a diesel exhaust particle (DEP) extract (a model organic compound) were used to examine the acellular oxidative potential of synthetic ELF and non-ELF systems. We compared the effects of exposure to ufCB, FeSO{sub 4} and DEP extract on human alveolar epithelial Type II (A549) cells to determine the levels of oxidative stress, DNA single-strand breaks and interleukin-8 (IL-8) production in ELF and non-ELF systems. The effects of ufCB and FeSO{sub 4} on the acellular oxidative potential, cellular oxidative stress and DNA single-strand breakage were mitigated significantly by the addition of ELF, whereas there was no decrease following treatment with the DEP extract. There was no significant effect on IL-8 production following exposure to samples that were suspended in ELF/non-ELF systems. The results of the present study indicate that ELF plays an important role in the initial defence against PM in the pulmonary environment. Experimental components, such as ufCB and FeSO{sub 4}, induced the production of oxidative stress and led to DNA single-strand breaks, which were moderately prevented by the addition of ELF. These findings suggest that ELF plays a protective role against PM-driven oxidative stress and DNA damage. -- Highlights: ► To determine the role of ELF in ROS, DNA damage and IL-8 after exposure to PM. ► ufCB, FeSO{sub 4} and DEP extract were used to examine the protective effects of ELF. ► PM-driven oxidative stress and DNA single-strand breakage were mitigated by ELF. ► The findings

  12. How to get more from less. Comments on "Extracting physics of life at the molecular level: A review of single-molecule data analyses" by W. Colomb and S.K. Sarkar

    Science.gov (United States)

    Sachs, Frederick; Flomenbom, Ophir

    2015-06-01

    Measuring individual entities at room temperature has become routine due to improvements in technology. We can study ion channels (since the 70s), quantum dots (since the 80s), and receptors, molecular engines and enzymes (since the 90s). The inherent nature of these small systems is that the standard deviation of the measurement is comparable to the mean - the definition of a small system [1]. Individual probes are detected, measured, and the trajectories are then analyzed to extract the mean properties of the system. The review [2] provides links to many examples of single molecule studies, mostly those using optical probes.

  13. One abutment-one time versus a provisional abutment in immediately loaded post-extractive single implants: a 1-year follow-up of a multicentre randomised controlled trial.

    Science.gov (United States)

    Grandi, Tommaso; Guazzi, Paolo; Samarani, Rawad; Maghaireh, Hassan; Grandi, Giovanni

    2014-01-01

    To compare immediately loaded post-extractive single implants using a definitive abutment versus provisional abutment later replaced by custom-made abutment. In two private clinics, 28 patients in need of one single post-extractive implant in the maxilla or mandible from the left second premolar to the right second premolar area were randomised shortly before tooth extraction to provisional abutment (PA) and definitive abutment (DA) groups. Three patients had to be excluded for buccal wall fracture after tooth extraction. In the PA group, implants were immediately restored using a platform-switched provisional titanium abutment and definitive platform-switched titanium abutments were used in the DA group. In both groups, a non-occluding provisional single crown was provided. Implants were definitively restored after 4 months. In the PA group, the abutment was removed and the impression was made directly on the implant platform. In the DA group an impression of the abutment was made using a retraction cord. Outcome measures were: implant failures; complications; and marginal peri-implant bone level changes. Patients were followed up to 1 year after loading. Twelve patients were randomised to the DA group and 13 patients to the PA group. At the 12-month follow-up, no implant failed. One biological complication occurred in the DA group and one mechanical complication occurred in the PA group. All complications were successfully treated. One year after loading, implants in the DA group lost an average of 0.11 mm (SD: 0.06) of periimplant bone and implants in PA group about 0.58 mm (SD: 0.11). At the 12-month follow-up, there was a statistically significant difference in bone level change between groups (mean difference: 0.48 mm, CI 95% 0.40; 0.55, P < 0.0001). Within the limits of this study, the non-removal of abutments placed at the time of surgery resulted in the maintenance of 0.5 mm more bone levels around immediately restored postextractive single implants than

  14. Hatchability of chicken eggs as influenced by turning frequency in ...

    African Journals Online (AJOL)

    An experiment was conducted to determine the influence of turning frequency of chicken eggs on hatchability in hurricane lantern incubator. There were four treatments in which eggs were not turned in treatment one (control), those in treatment two were turned once daily (morning), treatment three turned twice daily ...

  15. Analysis of forces in ultrasonically assisted turning

    Science.gov (United States)

    Ahmed, N.; Mitrofanov, A. V.; Babitsky, V. I.; Silberschmidt, V. V.

    2007-12-01

    Many modern engineering materials are very difficult to process with conventional machining methods. Ultrasonically assisted turning (UAT) is a new technology, where high frequency vibration (frequency f≈20 kHz, amplitude a≈15 μm) is superimposed on the movement of the cutting tool. Compared to conventional turning (CT), UAT allows significant improvements in processing many intractable materials, such as high-strength aerospace alloys and composites, by producing a noticeable decrease in cutting forces and a superior surface finish. Vibro-impact interaction between the tool and workpiece in UAT during the chip formation leads to a dynamically changing cutting force in the process zone as compared to the quasistatic one in CT. The paper presents an experimental study and computational (finite-element) model of both CT and UAT. Forces acting on the cutting tool in UAT are studied, and their dependence on vibration amplitude, frequency and vibration direction as well as on cutting parameters, such as feed rate and cutting speed, are investigated.

  16. Treatment of an adult with a normodivergent, mild skeletal Class III pattern, and a Bolton′s discrepancy using a single mandibular incisor extraction plan

    Directory of Open Access Journals (Sweden)

    Sunjay Suri

    2015-01-01

    Full Text Available A 34½-year-old pathologist with active social and professional interaction sought orthodontic solutions for severe esthetic and functional impairment. She felt due to spaced and protruding maxillary incisors, but had not got treatment previously as she did not want to wear metallic appliances. The diagnosis revealed a skeletal Class III normodivergent pattern with relative mandibular excess tooth material. Treatment with multibracket fixed appliances using ceramic brackets, extraction of a mandibular central incisor, maxillary incisor crown recontouring with interproximal reduction, and using gentle space closure mechanics ameliorated the problems and provided an esthetically pleasing, functionally adequate occlusion with good intercuspation.

  17. Graphene-silica hybrid in efficient preconcentration of heavy metal ions via novel single-step method of moderate centrifugation-assisted dispersive micro solid phase extraction.

    Science.gov (United States)

    Ghazaghi, Mehri; Mousavi, Hassan Zavvar; Rashidi, Ali Morad; Shirkhanloo, Hamid; Rahighi, Reza

    2016-04-01

    Novel nanoadsorbent of graphene-silica hybrid was synthesized via chemical vapor deposition (CVD) method. Graphene sheets were catalytically grown on a silica-based substrate and after being characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM), their high efficacy in adsorption of metal ions (lead, cadmium, and chromium) was examined. It was found that the presence of silica within the G-SiO2 structure imparts an amphiphilic property to the hybrid that enables it to interact with both free and bounded metal ions present in the biological samples. Utilization of the innovative method of moderate centrifugation-assisted dispersive micro solid phase extraction (MCDµSPE) coupled with electrothermal atomic absorption spectrometry (ETAAS), not only facilitated absolute separation of the fabricated nanoadsorbent from the solvent, but also helped complete recovering of the scant volume of desorbed supernatant. Thus, microliter amount of desorption solvent can be regained completely by MCDµSPE method without sorbent loss. Various parameters affecting the extraction efficiency were investigated and admirable linearity from 0.012 to 12.5 µg L(-1) and favorable detection limits (LOD) could be recorded. Intra day precision (RSD, n=10) ranged from 3.1 to 3.8%, whereas inter day precision (RSD, n=5) ranged from 6.3 to 7.2%. Copyright © 2015 Elsevier B.V. All rights reserved.

  18. The Impact of a Single Dose of a Polyphenol-Rich Seaweed Extract on Postprandial Glycaemic Control in Healthy Adults: A Randomised Cross-Over Trial

    Directory of Open Access Journals (Sweden)

    Margaret Murray

    2018-02-01

    Full Text Available This study investigated the impact of a polyphenol-rich seaweed extract on postprandial glycaemia in healthy adults, and, as a secondary outcome, the influence of ethnicity on these outcomes. Thirty-eight volunteers (26 non-Asian, 12 Asian aged 19 to 56 years participated in this double-blind, placebo-controlled, randomised cross-over trial. Participants each consumed a low (500 mg, and high (2000 mg dose of the polyphenol-rich brown seaweed (Fucus vesiculosus extract, as well as a cellulose placebo (2000 mg, 30 min prior to 50 g of available carbohydrate from white bread. Postprandial blood glucose and plasma insulin concentrations were measured over two hours (fasting, 15, 30, 45, 60, 90, and 120 min from a finger prick blood sample. Data were analysed using a repeated measures analysis of variance. Compared with the placebo, neither dose had a lowering effect on postprandial glucose or insulin responses. However, individuals of an Asian background experienced consistently elevated plasma insulin responses, assessed using an incremental area under the curve, compared with non-Asian participants, irrespective of supplement (p = 0.016. These results suggest an increased risk of insulin resistance among Asian populations, compared with non-Asian, and that measurement of blood glucose levels alone may be insufficient to diagnose diabetes risk in this population.

  19. The performance of stroke survivors in turning-while-walking while carrying out a concurrent cognitive task compared with controls.

    Directory of Open Access Journals (Sweden)

    Wing-Nga Chan

    Full Text Available Turning-while-walking is one of the commonest causes of falls in stroke survivors. It involves cognitive processing and may be challenging when performed concurrently with a cognitive task. Previous studies of dual-tasking involving turning-while-walking in stroke survivors show that the performance of physical tasks is compromised. However, the design of those studies did not address the response of stroke survivors under dual-tasking condition without specifying the task-preference and its effect on the performance of the cognitive task.First, to compare the performance of single-tasking and dual-tasking in stroke survivors. Second, to compare the performance of stroke survivors with non-stroke controls.Fifty-nine stroke survivors and 45 controls were assessed with an auditory Stroop test, a turning-while-walking test, and a combination of the two single tasks. The outcome of the cognitive task was measured by the reaction time and accuracy of the task. The physical task was evaluated by measuring the turning duration, number of steps to turn, and time to complete the turning-while-walking test.Stroke survivors showed a significantly reduced accuracy in the auditory Stroop test when dual-tasking, but there was no change in the reaction time. Their performance in the turning-while-walking task was similar under both single-tasking and dual-tasking condition. Additionally, stroke survivors demonstrated a significantly longer reaction time and lower accuracy than the controls both when single-tasking and dual-tasking. They took longer to turn, with more steps, and needed more time to complete the turning-while-walking task in both tasking conditions.The results show that stroke survivors with high mobility function performed the auditory Stroop test less accurately while preserving simultaneous turning-while-walking performance. They also demonstrated poorer performance in both single-tasking and dual-tasking as compared with controls.

  20. Childrens' left-turning preference is not modulated by magical ideation.

    Science.gov (United States)

    Streuli, Jürg C; Obrist, Gina; Brugger, Peter

    2017-01-01

    The literature on human turning preferences is inconsistent. While the few studies with children below 14 years of age uniformly describe an overall left-turning (counterclockwise) tendency, a recent Internet study with more than 1500 adults found a right-sided (clockwise) bias. We set out to investigate spontaneous turning behaviour in children age 5-3 years and, based on neuropsychiatric work in adults, also explored a potential association with magical thinking. Findings indicated a clear left-turning preference, independent of a participant's sex and handedness. Whether a child responded a question about the existence of extrasensory communication in the affirmative or not was unrelated to direction and size of turning bias and lateral preference. Our results are consistent with a left-sided turning preference reported for children, but in opposition to the clockwise bias recently described in a large-scale study with adults. Whether they point to a maturational gradient in the preferred direction of spontaneous whole-body rotation or rather to a lack of comparability between measures used in observational versus Internet-based studies remains to be further investigated. Regarding a purported association between body turns and magical thinking, our study is preliminary, as only one single question was used to probe the latter.

  1. Single drop based-liquid phase microextraction using ionic liquid as extractor solvent for extraction and preconcentration of copper and silver from food and water samples prior to determination by electrothermal atomic absorption spectrometry

    Directory of Open Access Journals (Sweden)

    j Abolhasani

    2013-08-01

    Full Text Available A new single drop micro-extraction method based on ionic liquids was developed for the pre-concentration of ultra-traces of silver and copper prior to its determination by electro-thermal atomic absorption spectrometry (ETAAS. An 8-μL drop of ionic liquid, 1-hexyl-3-methylimidazolium hexafluorophosphate, [C6MIM][PF6], was used for the extraction of silver and copper ions as dithizone complex. Important variables affecting microextraction efficiency and ETAAS signal, such as pyrolysis and atomization temperature, dithizone concentration, extraction time, drop volume and stirring rate were investigated and optimized. Under the optimum experimental conditions, the detection limits (3 s of the method were 4 and 8 ng L-1, for Ag and Cu, respectively and corresponding relative standard deviations (0.1 μg L-1, n = 6 were 4.2% and 4.8%. The developed method was successfully applied to the determination of copper and silver in food and water samples.

  2. Hard turning micro-machine tool

    Science.gov (United States)

    DeVor, Richard E; Adair, Kurt; Kapoor, Shiv G

    2013-10-22

    A micro-scale apparatus for supporting a tool for hard turning comprises a base, a pivot coupled to the base, an actuator coupled to the base, and at least one member coupled to the actuator at one end and rotatably coupled to the pivot at another end. A tool mount is disposed on the at least one member. The at least one member defines a first lever arm between the pivot and the tool mount, and a second lever arm between the pivot and the actuator. The first lever arm has a length that is less than a length of the second lever arm. The actuator moves the tool mount along an arc.

  3. Turned Back: Mad Men as Intermedial Melodrama

    Directory of Open Access Journals (Sweden)

    Monique Rooney

    2012-09-01

    Full Text Available This essay draws on definitions of gesture (Giorgio Agamben and Peter Brooks and catachresis (Peter Brooks, Jacques Derrida to examine the primacy of non-verbal signifiers as communicators of meaning in AMC’s Mad Men. Beginning with an analysis of Mad Men’s credit sequence, it draws attention to Mad Men’s use of gesture and catachresis in relation to melodrama’s privileging of non-verbal and naturalistic expression and its persistence as an intermedial mode that has moved back and forth between various media (theatre, novel, cinema, television and now digital formats. It argues that Mad Men’s melodramatic aesthetic is one that obliquely, and via a gestural and rhetorical ‘turned back’, communicates its relation to the past and the present.

  4. MEDIACRACY TURNS INTO A SYNONYM OF MEDIOCRITY?

    Directory of Open Access Journals (Sweden)

    Valentina CHIPER

    2014-11-01

    Full Text Available The link between freedom of speech and democracy is based on ideological legitimacy report. A new phenomenon which is worth noticing is the conversion of the freedom of expression from a freedom seen in certain aspects as a solitary freedom into a communication of the masses. Another challenge is prompted by the change of the traditional communication system at the dawn of technology, Internet and its various applications, as well as of the channels used. A weak point is the change in the values scale. If a journalist or a book is deemed good or valuable in terms of competence and ideas, these values are now unfortunately inspired by what we watch on TV. In this train of thoughts, reliable opinion leaders are no longer the same. Mediacracy turns into a synonym of mediocrity with affectivity and emotion prevailing over reason and instead of the communication of thoughts and opinions.

  5. Autism genes keep turning up chromatin.

    Science.gov (United States)

    Lasalle, Janine M

    2013-06-19

    Autism-spectrum disorders (ASD) are complex genetic disorders collectively characterized by impaired social interactions and language as well as repetitive and restrictive behaviors. Of the hundreds of genes implicated in ASD, those encoding proteins acting at neuronal synapses have been most characterized by candidate gene studies. However, recent unbiased genome-wide analyses have turned up a multitude of novel candidate genes encoding nuclear factors implicated in chromatin remodeling, histone demethylation, histone variants, and the recognition of DNA methylation. Furthermore, the chromatin landscape of the human genome has been shown to influence the location of de novo mutations observed in ASD as well as the landscape of DNA methylation underlying neurodevelopmental and synaptic processes. Understanding the interactions of nuclear chromatin proteins and DNA with signal transduction pathways and environmental influences in the developing brain will be critical to understanding the relevance of these ASD candidate genes and continued uncovering of the "roots" of autism etiology.

  6. Introduction: The Participatory Turn in Urbanism

    Directory of Open Access Journals (Sweden)

    Maroš Krivý

    2014-08-01

    Full Text Available This issue of Footprint examines the recent participatory turn in urban planning and urban design. It discusses the co-opting of participatory processes by planning departments, the systematic disregard of inequalities, and the empowering of the market resulting from the ‘anti-statism’ present in many participatory schemes.What is the relationship between the institutionalisation of participation and the practices of autonomy, self-organisation, and inclusion? When and how does genuine empowerment of collectives take place? Does the demand for the empowerment of local organisations and communities strengthen the market forces at the expense of central government?This issue attempts to problematise ‘participation’, to call attentions to some of its shortcomings, deficits, and limitations, not in order to necessarily bypass the demand for the democratisation of the urban, but in order to rectify and strengthen it.

  7. The experience turn as ‘bandwagon’

    DEFF Research Database (Denmark)

    Fuglsang, Lars; Eide, Dorthe

    2013-01-01

    further central processes, namely appropriation and narrowing the workspace. One Norwegian and one Danish network are studied using a case methodology. They are two rural networks of mainly small tourism firms. The empirical study confirms and illustrates how the bandwagon effect involves these three core......This paper uses the bandwagon metaphor to analyse, in two rural contexts, how small tourism firms become engaged in the idea of the experience economy and how the idea is turned into practice through network formation and innovation. In developing a practice-based approach we use the bandwagon...... metaphor to conceptualize network formation and innovation in terms of a ‘journey’. Following the practice-based literature on bandwagons, the journey starts by labelling an idea that is broad enough to give meaning to, and pull together, a number of diverse supporters. The journey also depends on two...

  8. Turning Video Resource Management into Cloud Computing

    Directory of Open Access Journals (Sweden)

    Weili Kou

    2016-07-01

    Full Text Available Big data makes cloud computing more and more popular in various fields. Video resources are very useful and important to education, security monitoring, and so on. However, issues of their huge volumes, complex data types, inefficient processing performance, weak security, and long times for loading pose challenges in video resource management. The Hadoop Distributed File System (HDFS is an open-source framework, which can provide cloud-based platforms and presents an opportunity for solving these problems. This paper presents video resource management architecture based on HDFS to provide a uniform framework and a five-layer model for standardizing the current various algorithms and applications. The architecture, basic model, and key algorithms are designed for turning video resources into a cloud computing environment. The design was tested by establishing a simulation system prototype.

  9. Reshape of the bunch-by-bunch BPM signal to turn-by-turn matrix during the fast rf frequency sweeping time in Booster

    International Nuclear Information System (INIS)

    Yang, Xi; Ankenbrandt, Charles M.; Lackey, James; Scarpine, Vic

    2004-01-01

    The bunch-by-bunch BPM signal array has to be reshaped into a turn-by-turn (TBT) matrix in order to make the TBT beam position information of a single bunch available for further data analysis, such as via the Fourier transform to obtain the synchrotron tune and betatron tune, etc. Since the RF frequency sweeps more than 10 MHz in the first 8 ms of a Booster cycle, the revolution time decreases more than 20%. The number of data points for each Booster turn (BT) should be varied in the same pace with the revolution time since the sampling rate of a digital oscilloscope is usually fixed. And this can be done by pre-determining the relationship between the RF frequency and the time in a cycle via the curve fit

  10. Turning frequency in adult bedridden patients to prevent hospital-acquired pressure ulcer: A scoping review.

    Science.gov (United States)

    Jocelyn Chew, H-S; Thiara, Emelia; Lopez, Violeta; Shorey, Shefaly

    2018-04-01

    The aim of this study was to identify current research on turning frequencies of adult bed-bound patients and inform future turning practices for hospitals based on evidence-based practice. We undertook a scoping review framework that provided a transparent and systematic methodology using 8 electronic databases (CINAHL, PubMed, Cochrane Library, ScienceDirect, PsycINFO, Scopus, ProQuest, and Web of Science) to identify articles published from 2000 to 2016. Articles were included if they focused on the prevention of hospital-acquired pressure ulcers related to the frequency of turning or repositioning of bed-bound patients. Literature search and data extraction were performed independently by 3 authors. The study followed the PRISMA guidelines. In total, 911 articles were identified, of which 10 were eligible. Of the eligible articles, 8 studies could not reach a conclusion on the effective frequency of turning and duration for repositioning patients to prevent the development of pressure ulcers. Only 2 studies found significant differences among the intervention and control groups. Results regarding turning and repositioning schedules are inconclusive; however, the topic needs further exploration to improve the outdated guidelines surrounding pressure ulcer prevention. This may, in turn, make the work of nurses more efficient and make treatment cost-effective for both the patients and the hospitals. © 2017 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

  11. Performance of Single-Use FlexorVue vs Reusable BoaVision Ureteroscope for Visualization of Calices and Stone Extraction in an Artificial Kidney Model.

    Science.gov (United States)

    Schlager, Daniel; Hein, Simon; Obaid, Moaaz Abdulghani; Wilhelm, Konrad; Miernik, Arkadiusz; Schoenthaler, Martin

    2017-11-01

    To evaluate and compare Flexor ® Vue™, a semidisposable endoscopic deflection system with disposable ureteral sheath and reusable visualization source, and a nondisposable fiber optic ureteroscope in a standard in vitro setting. FlexorVue and a reusable fiber optic flexible ureteroscope were each tested in an artificial kidney model. The experimental setup included the visualization of colored pearls and the extraction of calculi with two different extraction devices (NCircle ® and NGage ® ). The procedures were performed by six experienced surgeons. Visualization time, access to calices, successful stone retraction, and time required were recorded. In addition, the surgeons' workload and subjective performance were determined according to the National Aeronautics and Space Administration-task load index (NASA-TLX). We referred to the Likert scale to assess maneuverability, handling, and image quality. Nearly all calices (99%) were correctly identified using the reusable scope, indicating full kidney access, whereas 74% of the calices were visualized using FlexorVue, of which 81% were correctly identified. Access to the lower poles of the kidney model was significantly less likely with the disposable device, and time to completion was significantly longer (755 s vs 153 s, p < 0.001). The stone clearance success rate with the disposable device was 23% using the NGage and 13% using the NCircle basket. Overall NASA-TLX scores were significantly higher using FlexorVue. The conventional reusable device also demonstrated superior maneuverability, handling, and image quality. FlexorVue offers a semidisposable deflecting endoscopic system allowing basic ureteroscopic and cystoscopic procedures. For its use as an addition or replacement for current reusable scopes, it requires substantial technical improvements.

  12. Turning to Ontology in STS? Turning to STS through ‘Ontology’

    NARCIS (Netherlands)

    van Heur, B.; Leydesdorff, L.; Wyatt, S.

    2012-01-01

    We examine the evidence for the claim of an ‘ontological turn’ in science and technology studies (STS). Despite an increase in references to ‘ontology’ in STS since 1989, we show that there has not so much been an ontological turn as multiple discussions deploying the language of ontology,

  13. A time-motion analysis of turns performed by highly ranked viennese waltz dancers.

    Science.gov (United States)

    Prosen, Jerneja; James, Nic; Dimitriou, Lygeri; Perš, Janez; Vučković, Goran

    2013-01-01

    Twenty-four dance couples performing at the 2011 IDSF (International DanceSport Federation) International Slovenia Open were divided into two groups: the first twelve placed couples (top ranked) and the last twelve placed couples (lower ranked). Video recordings were processed automatically using computer vision tracking algorithms under operator supervision to calculate movement parameters. Time and speed of movement were analysed during single natural (right) and reverse (left) turns performed during the Viennese waltz. Both top and lower ranked dancers tended to perform similar proportionate frequencies of reverse (≈ 35%) and natural (≈ 65%) turns. Analysis of reverse turns showed that the top ranked dancers performed less turns on a curved trajectory (16%) than the lower ranked dancers (33%). The top ranked couples performed all turns at similar speeds (F = 1.31, df = 3, p = 0.27; mean = 2.09m/s) all of which were significantly quicker than the lower ranked couples (mean = 1.94m/s), the greatest differences found for reverse turns (12.43% faster for curved trajectories, 8.42% for straight trajectories). This suggests that the ability to maintain a high speed in the more difficult turns, particularly the reverse turns on a curved trajectory, results in the overall dance appearing more fluent as the speed of movement does not fluctuate as much. This aspect of performance needs to be improved by lower ranked dancers if they wish to improve rating of their performance. Future research should determine which factors relate to the speed of turns.

  14. Europe joins the race to turn the Internet into one vast computer

    CERN Multimedia

    Butler, D

    2000-01-01

    CERN is coordinating an European proposal to design internet and software protocols to turn the internet into a single gigantic computer - a 'grid'. The impetus has come from the challenges surrounding the analysis of the vast amounts of data which will be generated by the LHC (1 page).

  15. Mimicry by asx- and ST-turns of the four main types of beta-turn in proteins.

    Science.gov (United States)

    Duddy, William J; Nissink, J Willem M; Allen, Frank H; Milner-White, E James

    2004-11-01

    Hydrogen-bonded beta-turns in proteins occur in four categories: type I (the most common), type II, type II', and type I'. Asx-turns resemble beta-turns, in that both have an NH. . .OC hydrogen bond forming a ring of 10 atoms. Serine and threonine side chains also commonly form hydrogen-bonded turns, here called ST-turns. Asx-turns and ST-turns can be categorized into four classes, based on side chain rotamers and the conformation of the central turn residue, which are geometrically equivalent to the four types of beta-turns. We propose asx- and ST-turns be named using the type I, II, I', and II' beta-turn nomenclature. Using this, the frequency of occurrence of both asx- and ST-turns is: type II' > type I > type II > type I', whereas for beta-turns it is type I > type II > type I' > type II'. Almost all type II asx-turns occur as a recently described three residue feature named an asx-nest.

  16. Mimicry by asx- and ST-turns of the four main types of β-turn in proteins

    Science.gov (United States)

    Duddy, William J.; Nissink, J. Willem M.; Allen, Frank H.; Milner-White, E. James

    2004-01-01

    Hydrogen-bonded β-turns in proteins occur in four categories: type I (the most common), type II, type II’, and type I’. Asx-turns resemble β-turns, in that both have an NH. . .OC hydrogen bond forming a ring of 10 atoms. Serine and threonine side chains also commonly form hydrogen-bonded turns, here called ST-turns. Asx-turns and ST-turns can be categorized into four classes, based on side chain rotamers and the conformation of the central turn residue, which are geometrically equivalent to the four types of β-turns. We propose asx- and ST-turns be named using the type I, II, I’, and II’ β-turn nomenclature. Using this, the frequency of occurrence of both asx- and ST-turns is: type II’ > type I > type II > type I’, whereas for β-turns it is type I > type II > type I’ > type II’. Almost all type II asx-turns occur as a recently described three residue feature named an asx-nest. PMID:15459339

  17. Predicting turns in proteins with a unified model.

    Directory of Open Access Journals (Sweden)

    Qi Song

    Full Text Available MOTIVATION: Turns are a critical element of the structure of a protein; turns play a crucial role in loops, folds, and interactions. Current prediction methods are well developed for the prediction of individual turn types, including α-turn, β-turn, and γ-turn, etc. However, for further protein structure and function prediction it is necessary to develop a uniform model that can accurately predict all types of turns simultaneously. RESULTS: In this study, we present a novel approach, TurnP, which offers the ability to investigate all the turns in a protein based on a unified model. The main characteristics of TurnP are: (i using newly exploited features of structural evolution information (secondary structure and shape string of protein based on structure homologies, (ii considering all types of turns in a unified model, and (iii practical capability of accurate prediction of all turns simultaneously for a query. TurnP utilizes predicted secondary structures and predicted shape strings, both of which have greater accuracy, based on innovative technologies which were both developed by our group. Then, sequence and structural evolution features, which are profile of sequence, profile of secondary structures and profile of shape strings are generated by sequence and structure alignment. When TurnP was validated on a non-redundant dataset (4,107 entries by five-fold cross-validation, we achieved an accuracy of 88.8% and a sensitivity of 71.8%, which exceeded the most state-of-the-art predictors of certain type of turn. Newly determined sequences, the EVA and CASP9 datasets were used as independent tests and the results we achieved were outstanding for turn predictions and confirmed the good performance of TurnP for practical applications.

  18. Immediate, immediate-delayed (6 weeks) and delayed (4 months) post-extractive single implants: 1-year post-loading data from a randomised controlled trial.

    Science.gov (United States)

    Esposito, Marco; Zucchelli, Giovanni; Cannizzaro, Gioacchino; Checchi, Luigi; Barausse, Carlo; Trullenque-Eriksson, Anna; Felice, Pietro

    To compare the clinical outcome of single implants placed immediately after tooth extraction with implants placed 6 weeks after tooth extraction (immediate-delayed placement), and with implants placed after 4-month extraction and socket healing (delayed placement). Two-hundred and ten (210) patients requiring a single implant-supported crown to replace a tooth to be extracted were randomised to receive immediate post-extractive implants (70 patients), immediate-delayed implants at 6 weeks (70 patients), and delayed implants after 4 months of healing (70 patients) according to a parallel group design. When needed, patients of the immediate and immediate-delayed group had the socket grafted with a bone substitute and covered with a resorbable membrane at implant placement. Sockets randomised to delayed implants were grafted in the same manner if poorly preserved or in the aesthetic areas (from second upper to second upper premolars). Implants inserted with at least 25 Ncm torque were left to heal unloaded for 4 months, whereas those inserted with less than 25 Ncm were left to heal unloaded for 6 months. Temporary crowns were delivered and were to be replaced by definitive ones after 4 months. Outcome measures were crown and implant failures, complications, peri-implant marginal bone level changes, aesthetically assessed using the pink esthetic score (PES), and patient satisfaction recorded by blinded assessors. Patients were followed up to 1 year post-loading. One year after loading, three patients dropped out from the immediate group, five from the immediate-delayed group, and six from the delayed group. Four implants (6%) failed in the immediate, four (6.2%) in the immediate-delayed, and one (1.6%) from the delayed group (P (chi-square test) = 0.369). Apart from the crowns (which failed due to implant losses), no other crown had to be remade. Six immediate, six immediate-delayed and four delayed implants were affected by one complication each (P

  19. Immediate, immediate-delayed (6 weeks) and delayed (4 months) post-extractive single implants: 4-month post-loading data from a randomised controlled trial.

    Science.gov (United States)

    Felice, Pietro; Zucchelli, Giovanni; Cannizzaro, Gioacchino; Barausse, Carlo; Diazzi, Michele; Trullenque-Eriksson, Anna; Esposito, Marco

    To compare the clinical outcome of single implants placed immediately after tooth extraction with implants placed 6 weeks after tooth extraction (immediate-delayed placement), and with implants placed after 4 months of extraction and socket healing (delayed placement). Two hundred and ten patients requiring a single implant-supported crown to replace a tooth to be extracted were randomised to receive immediate post-extractive implants (70 patients), immediate-delayed implants at 6 weeks (70 patients), and delayed implants after 4 months of healing (70 patients), according to a parallel group design. When needed, patients of the immediate and immediate-delayed group had the socket grafted with a bone substitute and covered with a resorbable membrane at implant placement. Sockets randomised to delayed implants were grafted in the same manner if poorly preserved or in the aesthetic areas (from second upper to second upper premolars). Implants inserted with at least 25 Ncm torque were left to heal unloaded for 4 months, whereas those inserted with less than 25 Ncm were left to heal unloaded for 6 months. Temporary crowns were delivered and were to be replaced by definitive ones after 4 months. Outcome measures were crown and implant failures, complications, peri-implant marginal bone level changes, aesthetics assessed using the pink esthetic score (PES) and patient satisfaction recorded by blinded assessors. Three patients dropped out from the immediate, five from the immediate-delayed and six from the delayed group up to 4-months post-loading. Four implants (6.0%) failed in the immediate, four (6.2%) in the immediate-delayed and one (1.6%) from the delayed group (P (chi-square test) = 0.369). Apart from the crown failures due to implant losses, no other crown had to be remade. Five immediate, six immediate-delayed and three delayed implants were affected by one complication each (P (chi-square test) = 0.601). Mean peri-implant marginal bone

  20. Bioaccumulation of the synthetic dye Basic Violet 3 and heavy metals in single and binary systems by Candida tropicalis grown in a sugarcane bagasse extract medium: Modelling optimal conditions using response surface methodology (RSM) and inhibition kinetics

    International Nuclear Information System (INIS)

    Das, Devlina; Charumathi, D.; Das, Nilanjana

    2011-01-01

    Single and binary effects of dye Basic Violet 3 and heavy metals, 'namely', Pb(II) and Cd(II), were investigated for their role in dye and heavy metal bioaccumulation by Candida tropicalis that was grown in a sugarcane bagasse extract medium containing 8 g/L, 16 g/L or 24 g/L of sugar. The optimum pH was found to be 4.0 in the single system and 5.0 in the binary system. A central composite design was successfully used to analyse the experimental results. Four numerical correlations that were fitted to a second order quadratic equation were used to estimate optimum combinations predicted by response surface methodology. In the dye-Pb(II) binary system, C. tropicalis was capable of bioaccumulating 49.5% of the dye and 49.6% of the Pb(II), in comparison to 15.9% of the dye and 55.5% of the Cd(II) in the dye-Cd(II) binary system. In these two systems, the pollutants were dispersed at minimum working concentration levels. Competitive inhibition was observed in both the single and binary systems, which was suggested by an increase in the saturation constant, K s , and a simultaneous decrease in the specific growth rate that was calculated from Lineweaver-Burk plots. Atomic force microscopy images demonstrated changes in yeast cell morphology by exposure to these contaminants in the dye-Pb(II) binary system grown in a bioaccumulation medium.

  1. THE NEOLIBERAL TURN IN AMERICAN HEALTH CARE.

    Science.gov (United States)

    Gaffney, Adam

    2015-01-01

    Leaving millions both uninsured and underinsured, the Affordable Care Act does not create a system of universal health care in the United States. To understand its shortcomings, we have to understand it as part of a historic shift in the political economy of American health care. This "neoliberal turn" began as a reaction against the welfare state as it expanded during the New Deal and post-World War II period. What began as a movement associated with philosophers like Friedrich Hayek ultimately had a powerful impact via the attraction of powerful corporate sponsors and political supporters, and it was to historically transform American health care thought and organization. In health policy circles, for example, it can be seen in a rising emphasis on "moral hazard," overuse, and cost sharing above a concern with universalism and equity. It was likewise manifested by the corporatization of the health maintenance organization and the rise of the "consumer-driven" health care movement. By the time of the health care reform debate, the influence of corporate "stakeholders" was to prove predominant. These developments, however, must be construed as connected parts of a much larger political transformation, reflected in rising inequality and privatization, occurring both domestically and internationally.

  2. Cosmopolitan Pluralism: Beyond the Cultural Turn

    Directory of Open Access Journals (Sweden)

    Stephanie Lawson

    2011-11-01

    Full Text Available The ‘cultural turn’ has had a profound influence across the humanities and social sciences in the last few decades. In calling into question the universalist basis on which conventional methodological and normative assumptions have been based, the cultural turn has focused on the extent to which specificity and particularity underpin what we can know, how we can know it, and how this affects our being-in-the world. This has opened the way to a range of insights, from issues of pluralism and difference, both within political communities and between them, to the instability if not impossibility of foundations for knowledge. Too few studies embracing this ‘cultural turn’, however, pay more than cursory attention to the culture concept itself. This article suggests that conceptions of culture derived mainly from the discipline of anthropology dominate in political studies, including international relations, while humanist conceptions have been largely ignored or rejected. It argues further that we would do well to reconsider what humanist ideas can contribute to how ‘culture’ is both conceptualized and deployed in political thought and action, especially in countering the overparticularization of social and political phenomena that marks contemporary culturalist approaches.

  3. Now, It's Your Turn: How You Can Take Medicine Safely

    Science.gov (United States)

    ... please turn Javascript on. Feature: Taking Medicines Safely Now, It's Your Turn: How You Can Take Medicine ... a medicine. The pharmacist has filled the prescription. Now it's up to you to take the medicine ...

  4. Immediate non-occlusal loading of immediate post-extractive versus delayed placement of single implants in preserved sockets of the anterior maxilla: 4-month post-loading results from a pragmatic multicentre randomised controlled trial.

    Science.gov (United States)

    Felice, Pietro; Soardi, Elisa; Piattelli, Maurizio; Pistilli, Roberto; Jacotti, Michele; Esposito, Marco

    2011-01-01

    To compare the effectiveness of immediate post-extractive single implants with delayed implants placed in preserved sockets after 4 months of healing. Implants that achieved an insertion torque of at least 35 Ncm were immediately non-occlusally loaded. Just after tooth extraction and in the presence of a loss of the buccal plate bone less than 4 mm, compared to the palatal wall, 106 patients requiring a single immediate postextractive implant in the maxilla from second premolar to second premolar were randomly allocated to immediate implant placement (immediate group; 54 patients) or to socket preservation using anorganic bovine bone covered by a resorbable collagen barrier (delayed group; 52 patients) according to a parallel group design at three different centres. Bone-to-implant gaps were to be filled with anorganic bovine bone, however this was not done in 17 patients (corresponding to 40% of those who should have been grafted). Four months after socket preservation, delayed implants were placed. Implants placed with an insertion torque >35 Ncm were immediately loaded with non-occluding provisional single crowns, replaced, after 4 months, by definitive crowns. Outcome measures were implant failures, complications, aesthetics assessed using the pink esthetic score (PES), and patient satisfaction, recorded by blinded assessors. All patients were followed up to 4 months after loading. Nineteen (35%) implants were not immediately loaded in the immediate group versus 39 (75%) implants in the delayed placement group because an insertion torque >35 Ncm could not be obtained. No patient dropped out. Two implants failed in the immediate group (4%) versus none in the delayed group. More minor complications occurred in the immediate group (8) than the in the delayed group (1) and this was statistically significant (P = 0.032). At delivery of definitive crowns, 4 months after loading, aesthetics were scored as 12.8 and 12.6 in the immediate and delayed groups, respectively

  5. Evaluation of stir-bar sorptive extraction coupled with thermal desorption GC-MS for the detection of leachables from polymer single use systems to drugs.

    Science.gov (United States)

    Scherer, Nicole; Marcseková, Klaudia; Posset, Tobias; Winter, Gerhard

    2018-04-15

    Stir-bar Sorptive Extraction (SBSE) in combination with thermal desorption and gas chromatography-mass spectrometry (TD-GC-MS) is widely accepted as the gold-standard analysis method for trace amounts of organic substances, including leachables in aqueous matrices. Meanwhile, as far as pharmaceutical quality control in protein-based parenteral drugs is concerned, the use of SBSE analysis remains unexplored. Previous studies reported a strong influence of the matrix on the method's recovery. The scope of the present work was to fill in the unexplored territory in a threefold manner 1) by quantifying the effects that various matrices commonly found in pharmaceutical processing have on the recovery, 2) by comparing between different coating materials for stir bar (namely between polydimethylsiloxane (PDMS) material and ethylene-glycol (EG)-PDMS), and 3) by proposing a preparation step for stir-bar to mitigate inhibitory effects. The current study shows no inhibition of SBSE by protein matrices (p > 0.15). Further the influence of various drug matrices on the recovery of leachables with a log K o/w  ≥ 3.6 is negligible (-3.9 to 3.8%). In contrast, the inhibition effect caused by an alkaline media led to a recovery decrease of -42.9%. For leachables with a log K o/w   0.992). On average, the conventional PDMS coating resulted in a 28-fold higher signal-to-noise ratio compared to EG-PDMS. Furthermore, a broader range of leachables was detectable with the PDSM coating. Preceding stir-bar preparation consisting of a simple soaking step improved the enrichment by 14%, effectively lowering the limit of detection. Copyright © 2018 Elsevier B.V. All rights reserved.

  6. Short term study of human skin irritation by single application closed patch test: assessment of four multiple emulsion formulations loaded with botanical extracts.

    Science.gov (United States)

    Mahmood, Tariq; Akhtar, Naveed

    2013-03-01

    Assessment of skin irritation potential is a major concern in safety assessment of cosmetics, when long-term use of these products are expected. Non-invasive bioengineering probes have been used previously to measure skin irritation potential of cosmetic ingredients. Experimentation carried out to weigh up the skin irritation potential of four multiple emulsion formulations via visual and non-invasive measurements. Immediate effects of formulations and comparison of two assessment techniques were also tried to establish. Four multiple emulsion formulations one control (without botanical active) and three containing the functional botanical actives plus additives were tested in this study using the following techniques: transepidermal water loss (TEWL), COLIPA visual scoring method (CVSM), Mexameter MPA 5 (Courage + Khazaka, Germany) and capacitance [Corneometer MPA 5 (Courage + Khazaka, Germany)]. Visual examination and non-invasive measurements were performed at baseline and after 24 h. The formulations were applied on the forearm of 12 healthy volunteers of same sexes aged 20-25 years. We found that none of the formulation produced irritation both on visual and instrumental evaluation. However, formulations MeB and MeC have comparable immediate effects on dryness, erythema, melanin and TEWL. Formulation MeC produced more effective results on different parameters, may be due to synergistic effect of two extracts, while MeA failed to produce any immediate effects on skin parameters. Moreover results of both assessment methods are parallel to each other. None of the formulation produce irritant effects, barrier impairment effects or immediate effects except for the formulation MeC which produced appreciable results than other formulations but statistically these results were insignificant (p > 0.05). Based on these results, it could be concluded that formulations may be implied safely as skin rejuvenating candidates.

  7. Developmental toxicity of clarified slurry oil, syntower bottoms, and distillate aromatic extract administered as a single oral dose to pregnant rats

    Energy Technology Data Exchange (ETDEWEB)

    Feuston, M.H.; Mackerer, C.R. [Stonybrook Labs., Princeton, NJ (United States)

    1996-09-01

    Clarified slurry oil (CSO), syntower bottoms (STB), and distillate aromatic extract (DAE) are refinery streams produced by processing crude oil. Available data indicate that some refinery streams are developmentally toxic by the dermal route of exposure. However, there is no conclusive evidence for their being teratogenic. The present studies were designed to further explore the suspected teratogenic potency of refinery streams while at the same time limiting embryolethality. In general, evidence of maternal toxicity (i.e., decreased body weight gain, decreased thymus weight) was observed at doses greater than or equal to 500 mg/kg. For each refinery stream tested, the incidence of resorption was greatest on GD 11. A common pattern of fetal malformations was observed for all of the refinery streams tested and included cleft palate, diaphragmatic hernia, and paw and tail defects. The incidence and type of malformation observed were influenced by the gestation day of exposure. The incidence and type of malformation observed were influenced by the gestation day of exposure. The incidences of external and skeletal malformations were greatest on GD 11 and 12 for fetuses exposed to CSO; on GD 13 and 14, the incidence of malformation was comparable for CSO- and STB-exposed fetuses. The incidence of visceral anomalies was greatest on GD 11-13 for fetuses exposed to CSO and STB; on Gestation D 14, the incidence was comparable for each of the refinery streams tested. In general, the ability to produce adverse effects on development was greatest for CSO and least for DAE. Effects produced by STB were comparable to or less severe than those observed for CSO. 24 refs., 11 tabs.

  8. 14 CFR 417.209 - Malfunction turn analysis.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Malfunction turn analysis. 417.209 Section...'s turning capability using a set of turn curves. The analysis must account for: (1) All trajectory... the thrusting phases of flight. The analysis must account for trajectory time intervals between...

  9. History of Education in Canada: Historiographic "Turns" and Widening Horizons

    Science.gov (United States)

    Bruno-Jofré, Rosa

    2014-01-01

    This paper explores major historiographic "turns" in history of education with a focus, although not exclusively, on English-speaking Canada. It addresses the transformative intellectual impact of the turn toward social history on the history of education, the impact of cultural history and the linguistic turn, the reception of Michel…

  10. Turn Openings in Academic Talk: Where Goals and Roles Intersect

    Science.gov (United States)

    Evison, Jane

    2013-01-01

    This study uses Corpus Linguistic (CL) techniques to explore multiple turn openings in conjunction with comparative measures of turn-initial priming (the proportion of occurrences of a form that are turn-initial). Using a benchmark corpus of casual conversation as a point of comparison, six frequent items which have a particularly strong affinity…

  11. First turn simulations in the cooler synchrotron COSY

    International Nuclear Information System (INIS)

    Dinev, D.

    1991-07-01

    This paper is devoted to the first turn correction and related problems in particle accelerators of synchrotron type. The paper consists of two parts. The first part is a survey of the existing methods for first turn steering. The second part is entirely devoted to the first turn in the cooler synchrotron COSY which is under assembling in KFA-Julich, Germany. (orig.)

  12. Rapid-Cycling Synchrotron extraction-kicker magent-drive system

    International Nuclear Information System (INIS)

    Suddeth, D.E.; Volk, G.J.

    1981-01-01

    The Rapid-Cycling Synchrotron (RCS) accelerator of the Intense Pulsed Neutron Source-I (IPNS-I) at Argonne National Laboratory utilizes a fast kicker magnet to provide single-turn extraction for a 500-MeV proton beam at a 30 Hz rate. The single-turn, 0.89-m-long ferrite magnet is broken up into two identical cells with four individual windings. Each winding requires a 4863-A magnetizing current into a 7.0-Ω load with a rise time of less than 100 ns and a flattop of about 140 ns. Pulse forming network (PFN) charging and switching techniques along with the components used will be described

  13. Immediate non-occlusal loading of immediate post-extractive versus delayed placement of single implants in preserved sockets of the anterior maxilla: 1-year post-loading outcome of a randomised controlled trial.

    Science.gov (United States)

    Felice, Pietro; Pistilli, Roberto; Barausse, Carlo; Trullenque-Eriksson, Anna; Esposito, Marco

    2015-01-01

    To compare the effectiveness of immediate post-extractive single implants with delayed implants placed in preserved sockets after 4 months of healing. Implants that achieved an insertion torque of at least 35 Ncm were immediately non-occlusally loaded. Just after tooth extraction, and in the presence of less than 4 mm of vertical loss of the buccal bone in relation to the palatal wall, 50 patients requiring a single immediate post-extractive implant in the maxilla from second to second premolar were randomly allocated for either immediate implant placement (immediate group; 25 patients) or for socket preservation using an algae-derived (phycogenic) bone substitute, covered by a resorbable collagen barrier (delayed group; 25 patients), according to a parallel group design in one centre. Bone-to-implant gaps were filled with an algae-derived bone substitute. Four months after socket preservation, delayed implants were placed. Implants inserted with an insertion torque of at least 35 Ncm were immediately loaded with non-occluding provisional single crowns, then replaced, after 4 months, by definitive crowns. Patients were followed up to 1 year after loading. Outcome measures were implant failures, complications, aesthetics assessed using the pink esthetic score (PES), peri-implant marginal bone level changes and patient satisfaction, recorded by blinded assessors. Nine (36%) implants were not immediately loaded in the immediate group versus 19 (76%) implants in the delayed placement group, because an insertion torque superior to 35 Ncm could not be obtained, the difference being statistically significant (difference = - 0.40, 95% CI: -0.652 to -0.148, P = 0.010). Two patients dropped out 4 months after loading in the delayed group versus none in the immediate group. Two implants failed in the immediate group (8%) versus none in the delayed group, with the difference showing no statistical significance (considering 25 and 23 patients, the difference in proportions was

  14. Turn-Based War Chess Model and Its Search Algorithm per Turn

    Directory of Open Access Journals (Sweden)

    Hai Nan

    2016-01-01

    Full Text Available War chess gaming has so far received insufficient attention but is a significant component of turn-based strategy games (TBS and is studied in this paper. First, a common game model is proposed through various existing war chess types. Based on the model, we propose a theory frame involving combinational optimization on the one hand and game tree search on the other hand. We also discuss a key problem, namely, that the number of the branching factors of each turn in the game tree is huge. Then, we propose two algorithms for searching in one turn to solve the problem: (1 enumeration by order; (2 enumeration by recursion. The main difference between these two is the permutation method used: the former uses the dictionary sequence method, while the latter uses the recursive permutation method. Finally, we prove that both of these algorithms are optimal, and we analyze the difference between their efficiencies. An important factor is the total time taken for the unit to expand until it achieves its reachable position. The factor, which is the total number of expansions that each unit makes in its reachable position, is set. The conclusion proposed is in terms of this factor: Enumeration by recursion is better than enumeration by order in all situations.

  15. Residual stress condition monitoring via sensor fusion in turning of Inconel 718

    OpenAIRE

    Simeone, A.; Segreto, T.; Teti, R.

    2013-01-01

    A multiple sensor monitoring system, equipped with cutting force, acoustic emission and vibration sensing units, was employed in association with advanced procedures for signal analysis, sensor fusion and cognitive decision making for residual stress evaluation in turning of Inconel 718 nickel alloy. Two signal processing and feature extraction methodologies, based respectively on sensory data statistical evaluation and Principal Component Analysis, were applied to the sensor signals generate...

  16. A highly efficient type I β-turn mimetic simulating an Asx-Pro-turn-like structure.

    Science.gov (United States)

    Pinsker, Andrea; Einsiedel, Jürgen; Härterich, Steffen; Waibel, Reiner; Gmeiner, Peter

    2011-07-01

    Asx-Pro-turns have been identified with high frequency in protein structures nucleating type I β-turns. By bridging the amino acid side chain in position i with a nitrogen substituent in position i+2 by ring-closing olefin metathesis (RCM), peptide mimetics of type 1 could be developed. NMR based conformational investigations indicated a stable intramolecular H-bond constraining a U-turn conformation that was predicted to simulate a type I β-turn.

  17. A Randomized Single Blind Parallel Group Study Comparing Monoherbal Formulation Containing Holarrhena antidysenterica Extract with Mesalamine in Chronic Ulcerative Colitis Patients

    Directory of Open Access Journals (Sweden)

    Sarika Johari

    2016-01-01

    Full Text Available Background: Incidences of side effects and relapses are very common in chronic ulcerative colitis patients after termination of the treatment. Aims and Objectives: This study aims to compare the treatment with monoherbal formulation of Holarrhena antidysenterica with Mesalamine in chronic ulcerative colitis patients with special emphasis to side effects and relapse. Settings and Design: Patients were enrolled from an Ayurveda Hospital and a private Hospital, Gujarat. The study was randomized, parallel group and single blind design. Materials and Methods: The protocol was approved by Institutional Human Research Ethics Committee of Anand Pharmacy College on 23rd Jan 2013. Three groups (n = 10 were treated with drug Mesalamine (Group I, monoherbal tablet (Group II and combination of both (Group III respectively. Baseline characteristics, factors affecting quality of life, chronicity of disease, signs and symptoms, body weight and laboratory investigations were recorded. Side effects and complications developed, if any were recorded during and after the study. Statistical Analysis Used: Results were expressed as mean ± SEM. Data was statistically evaluated using t-test, Wilcoxon test, Mann Whitney U test, Kruskal Wallis test and ANOVA, wherever applicable, using GraphPad Prism 6. Results: All the groups responded positively to the treatments. All the patients were positive for occult blood in stool which reversed significantly after treatment along with rise in hemoglobin. Patients treated with herbal tablets alone showed maximal reduction in abdominal pain, diarrhea, and bowel frequency and stool consistency scores than Mesalamine treated patients. Treatment with herbal tablet alone and in combination with Mesalamine significantly reduced the stool infection. Patients treated with herbal drug alone and in combination did not report any side effects, relapse or complications while 50% patients treated with Mesalamine exhibited the relapse with

  18. Development of an ultra-fast liquid chromatography-tandem mass spectrometry method for simultaneous determination of seven flavonoids in rat plasma: Application to a comparative pharmacokinetic investigation of Ginkgo biloba extract and single pure ginkgo flavonoids after oral administration.

    Science.gov (United States)

    Wang, Tianyang; Xiao, Jie; Hou, Huiping; Li, Pei; Yuan, Ziyue; Xu, Huarong; Liu, Ran; Li, Qing; Bi, Kaishun

    2017-08-15

    For deeper pharmacokinetic investigation and further curative application of ginkgo flavonoids, a delicate, efficient and precise UFLC-MS/MS technique for synchronous quantitation of seven flavonoids, apigenin, luteolin, naringenin, quercetin, diosmetin, kaempferol and isorhamnetin in rat plasma has been established. After mixing with the internal standard (IS) linarin, bio-samples were pretreated via ethyl acetate for liquid-liquid extraction, then isolated at 0.2ml/min flow rate on a Venusil MP C 18 chromatographic column (100mm×2.1mm, 3μm) by means of gradient elution. 0.1% formic acid-water and methanol system was used as the mobile phase. Mass spectrometric inspection was conducted on a 4000Q UFLC-MS/MS system with turbo ion spray source in patterns of negative ion and multiple reaction-monitoring (MRM). All calibration curves proved favorable linearity (R 2 ≥0.9918) in linear ranges. Intra-day and inter-day precisions didn't exceed 14.0% for all the analytes, and the accuracy was within 6.9%. Extraction recoveries of analytes and IS were less than ±15.0% of nominal concentrations. This method has been under thorough and firm verification for a comparative pharmacokinetic research after gavage between Ginkgo biloba extract and single pure ginkgo flavonoids. The results demonstrated that there're evident pharmacokinetic discrepancies, and possible structural influences were innovatively proposed. Generally, substitution with 3-hydroxylation, a double bond in ring C, ring B methoxylation often confer longer onset period. The existence of ring B catechol group gives rise to faster clearance. Copyright © 2017. Published by Elsevier B.V.

  19. Efficient cleavage of single and clustered AP site lesions within mono-nucleosome templates by CHO-K1 nuclear extract contrasts with retardation of incision by purified APE1

    Science.gov (United States)

    Eccles, Laura J.; Menoni, Hervé; Angelov, Dimitar; Lomax, Martine E.; O’Neill, Peter

    2015-01-01

    Clustered DNA damage is a unique characteristic of radiation-induced DNA damage and the formation of these sites poses a serious challenge to the cell’s repair machinery. Within a cell DNA is compacted, with nucleosomes being the first order of higher level structure. However, few data are reported on the efficiency of clustered-lesion processing within nucleosomal DNA templates. Here, we show retardation of cleavage of a single AP site by purified APE1 when contained in nucleosomal DNA, compared to cleavage of an AP site in non-nucleosomal DNA. This retardation seen in nucleosomal DNA was alleviated by incubation with CHO-K1 nuclear extract. When clustered DNA damage sites containing bistranded AP sites were present in nucleosomal DNA, efficient cleavage of the AP sites was observed after treatment with nuclear extract. The resultant DSB formation led to DNA dissociating from the histone core and nucleosomal dispersion. Clustered damaged sites containing bistranded AP site/8-oxoG residues showed no retardation of cleavage of the AP site but retardation of 8-oxoG excision, compared to isolated lesions, thus DSB formation was not seen. An increased understanding of processing of clustered DNA damage in a nucleosomal environment may lead to new strategies to enhance the cytotoxic effects of radiotherapeutics. PMID:26439176

  20. Costs of switching auditory spatial attention in following conversational turn-taking.

    Science.gov (United States)

    Lin, Gaven; Carlile, Simon

    2015-01-01

    Following a multi-talker conversation relies on the ability to rapidly and efficiently shift the focus of spatial attention from one talker to another. The current study investigated the listening costs associated with shifts in spatial attention during conversational turn-taking in 16 normally-hearing listeners using a novel sentence recall task. Three pairs of syntactically fixed but semantically unpredictable matrix sentences, recorded from a single male talker, were presented concurrently through an array of three loudspeakers (directly ahead and +/-30° azimuth). Subjects attended to one spatial location, cued by a tone, and followed the target conversation from one sentence to the next using the call-sign at the beginning of each sentence. Subjects were required to report the last three words of each sentence (speech recall task) or answer multiple choice questions related to the target material (speech comprehension task). The reading span test, attention network test, and trail making test were also administered to assess working memory, attentional control, and executive function. There was a 10.7 ± 1.3% decrease in word recall, a pronounced primacy effect, and a rise in masker confusion errors and word omissions when the target switched location between sentences. Switching costs were independent of the location, direction, and angular size of the spatial shift but did appear to be load dependent and only significant for complex questions requiring multiple cognitive operations. Reading span scores were positively correlated with total words recalled, and negatively correlated with switching costs and word omissions. Task switching speed (Trail-B time) was also significantly correlated with recall accuracy. Overall, this study highlights (i) the listening costs associated with shifts in spatial attention and (ii) the important role of working memory in maintaining goal relevant information and extracting meaning from dynamic multi-talker conversations.

  1. Costs of switching auditory spatial attention in following conversational turn-taking

    Directory of Open Access Journals (Sweden)

    Gaven eLin

    2015-04-01

    Full Text Available Following a multi-talker conversation relies on the ability to rapidly and efficiently shift the focus of spatial attention from one talker to another. The current study investigated the listening costs associated with shifts in spatial attention during conversational turn-taking in 16 normally-hearing listeners using a novel sentence recall task. Three pairs of syntactically fixed but semantically unpredictable matrix sentences, recorded from a single male talker, were presented concurrently through an array of three loudspeakers (directly ahead and +/-30° azimuth. Subjects attended to one spatial location, cued by a tone, and followed the target conversation from one sentence to the next using the call-sign at the beginning of each sentence. Subjects were required to report the last three words of each sentence (speech recall task or answer multiple choice questions related to the target material (speech comprehension task. The reading span test, attention network test, and trail making test were also administered to assess working memory, attentional control, and executive function. There was a 10.7 ± 1.3% decrease in word recall, a pronounced primacy effect, and a rise in masker confusion errors and word omissions when the target switched location between sentences. Switching costs were independent of the location, direction, and angular size of the spatial shift but did appear to be load dependent and only significant for complex questions requiring multiple cognitive operations. Reading span scores were positively correlated with total words recalled, and negatively correlated with switching costs and word omissions. Task switching speed (Trail-B time was also significantly correlated with recall accuracy. Overall, this study highlights i the listening costs associated with shifts in spatial attention and ii the important role of working memory in maintaining goal relevant information and extracting meaning from dynamic multi

  2. Can helical spring dextrin be composed of higher eight glucose units per turn?

    Science.gov (United States)

    Xu, Jin; Zhao, Wenxiu; Ning, Yawei; Bashari, Mohanad; Jin, Zhengyu; Xu, Baocai; Zhang, Lixia; Duan, Xiang; Chen, Haiying; Wu, Fengfeng; Xu, Xueming

    2013-03-01

    In this study, spring dextrin (SD) has been noncovalently wrapped onto single-wall carbon nanotubes (SWNTs) to explain the number of glucose residues per turn larger than eight. Differential scanning calorimetry (DSC), FR-IR and Raman spectroscopy demonstrated that SD formed supramolecular complex with SWNTs. Furthermore, Atomic force microscope (AFM) micrograph indicated that SD wrap around SWNTs into helical superstructures. Finally, molecular dynamic simulation suggested that the space of helix cavity changed with different diameter of SWNTs, and SD wrapped around SWNTs (1 nm, 1.5 nm and 2 nm) were 11, 14 and 17 glucose units per turn, respectively.

  3. and γγ-turns in proteins revisited: A new set of amino acid turn-type de

    Indian Academy of Sciences (India)

    mine, valine, glutamic acid and alanine has decreased for β-turns. Certain new amino acid preferences were observed for both turn types and individual amino acids showed turn-type dependent positional preferences. The rationale for new amino acid preferences are discussed in the light of hydrogen bonds and other.

  4. China's nuclear industry at a turning point

    International Nuclear Information System (INIS)

    Kubota, Hideo

    2009-01-01

    The China nuclear industry is coming at a turning point since the first Chinese nuclear power plant of Qinshan No.1 was started construction 24 years ago. At the end of year 2008, there are 11 nuclear power plants in operation in China. The total power capacity of the facilities has reached to 9068MW. It resulted in 11th position next to Sweden. Despite the nuclear power was reached to 68.4 billion KWh, it makes up only 2% of the total electric generation in China. The thermal power takes 81% of the total generation, in which the power by coal fuel takes for the most part and the total generation by both natural gas and oil fuel take only as small as a few percentage. In this situation, a nuclear power plant development is being accelerated. As of July 2009, China has 15 nuclear power plants currently under construction with a total capacity of 15260MW, that is more than 24000MW together with ones currently in operation. Furthermore, my research shows that China would have a plan to build 180 new nuclear power plants of 192770MW, though the progress varies widely. The construction speed of China nuclear power plant has become increasingly high since 2008. Starting with the construction of. Ningde unit 1 (PWR, 1110MW) in Fujian Province, February 2008, they continuously started constructions for five more nuclear power plants in year 2008 alone. China still holds momentum in a nuclear power plant construction even in 2009, and continues constructing new nuclear power plants. They include a Liaoning. Hongyanhe unit 3 in March, Sanmen Zhejiang April 19 which lead a construction first in the world for the third generation nuclear power plant of AP1000 (PWR, 1250MW) developed by Westinghouse, Fuqing unit 2 (PWR, 1000MW) June 17, and Fangjiashan unit 2 (PWR, 1000MW) on 17, July. Besides, Shidaowan, Rongcheng phase I (200MW), which is a demonstration reactor of HTGR in Shandong. They even said that China would start construction for approximately 7 to 9 nuclear power

  5. New ways to turn on NKT cells.

    Science.gov (United States)

    Godfrey, Dale Ian; Rossjohn, Jamie

    2011-06-06

    Natural killer T (NKT) cells are CD1d-restricted, lipid antigen-reactive T cells with powerful immunoregulatory potential. The prototypic antigen for NKT cells is a marine sponge-derived glycolipid, α-galactosylceramide (α-GalCer), but this is not normally encountered in the mammalian environment. Thus, there is great interest in the identification of more physiological stimuli for NKT cells, and numerous studies have shown that NKT cells are capable of responding to a range of microbial lipid-based antigens. Two new studies expand our understanding of environmental NKT cell stimuli, with one showing that CD1d-restricted NKT cell antigens are present within common house dust extract (HDE), whereas the other shows that NKT cells can respond to innate stimuli irrespective of the presence of foreign microbial antigens. Collectively, these two investigations indicate that NKT cells are far more likely to encounter foreign antigens, or innate activating signals, than previously recognized, suggesting a more central role for these cells in the immune system.

  6. Influence of Ginkgo biloba extract on the pharmacodynamic effects and pharmacokinetic properties of ticlopidine: an open-label, randomized, two-period, two-treatment, two-sequence, single-dose crossover study in healthy Korean male volunteers.

    Science.gov (United States)

    Kim, Bo-Hyung; Kim, Kyu-Pyo; Lim, Kyoung Soo; Kim, Jung-Ryul; Yoon, Seo Hyun; Cho, Joo-Youn; Lee, Yong-Oh; Lee, Kyung-Hee; Jang, In-Jin; Shin, Sang-Goo; Yu, Kyung-Sang

    2010-02-01

    Ginkgo biloba extract is an herbal medicine used in the treatment of vascular disorders that may be coadministered with antiplatelet agents such as ticlopidine. Regulatory authorities requested evaluation of the pharmacodynamic and pharmacokinetic interactions between these entities, according to the drug-development guidance for fixed-dose combination formulations in Korea. This study was performed to evaluate the potential pharmacodynamic and pharmacokinetic interactions between ticlopidine and Ginkgo biloba extract. An open-label, randomized, 2-period, 2-treatment, 2-sequence, single-dose crossover study was conducted in healthy Korean male volunteers. All volunteers were randomly assigned to a sequence group for the 2 treatments, which consisted of ticlopidine 250 mg alone and ticlopidine 250 mg with Ginkgo biloba extract 80 mg, separated by a 1-week washout period between the treatments. Bleeding time was determined just before dosing and at 5, 12, and 48 hours after dosing. Platelet aggregation was evaluated before dosing and at 4, 8, 26, and 48 hours after dosing. Blood samples (8 mL) from each of the volunteers were collected from an indwelling intravenous cannula inserted into a forearm vein before dosing and at 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8, 12, 24, and 48 hours after dosing. Ticlopidine concentrations were determined by a validated method using HPLC and ultraviolet detection. Adverse events were identified using general health-related questions, vital signs, physical examinations, ECGs, and laboratory tests. A total of 24 healthy men participated in the study (mean [SD] age, 24.1 [4.3] years; weight, 66.6 [7.4] kg; height, 174.7 [5.0] cm). The baseline corrected bleeding times were not significantly different between the ticlopidine-alone and ticlopidine/ Ginkgo biloba groups, and changes in platelet aggregation were not significantly different between the groups. Likewise, the pharmacokinetic parameters of ticlopidine were not significantly different

  7. Mapping the Glocal Turn: Literature Streams, Scholarship Clusters and Debates

    Directory of Open Access Journals (Sweden)

    Victor Roudometof

    2015-12-01

    accidental that the glocal has been invoked in the context of discussions about the “participatory web” or “Web 2.0” (Boyd 2005. It is obviously impossible to address all the twists and turns within the multitude of fields that have employed the terms glocal and glocalization in the course of a single discussion. Inevitably, a full treatment is reserved for a lengthier and more in-depth discussion elsewhere (Roudometof Forthcoming. In the following, then, I restrict myself to an overview of the employment of the glocal. Although I briefly touch on the employment of glocalization in business, I nonetheless concentrate on the humanities and social sciences. The goal is to present an overview of the various bodies of literature, to identify and discuss clusters of scholarship where glocalization is among the important research foci and to offer a brief overview of emerging debates within this nascent field of study. As I have stated elsewhere (Roudometof 2015 the glocal is a new word whose origins most likely lie somewhere in the early 1990s. It stands in sharp contrast to the global, the appearance of which dates back to the late 19th or early 20th centuries. The emergence of the glocal in scholarly discourse is a feature of the post-1989 era, and its rise has been ubiquitous after the turn of the millennium.

  8. Turn me on! Using the “Internet of Things” to turn things on and off

    CSIR Research Space (South Africa)

    Butgereit, L

    2011-10-01

    Full Text Available -directional. The thing in question is automatically posting data to a location on the Internet for people to read. Bi-directional communication between people and things via the Internet is less common. This paper describes a project TurnMeOn where people... traversed numerous times in this project leading to a final conclusion step. 4 General Architecture There are three major components of the platform: ThingMemory, Beachcomber, and UrbanControl. ThingMemory supplies the web interface and a...

  9. Non-local Fast Extraction from the CERN SPS at 100 and 440 GeV

    CERN Document Server

    Velotti, F M; Bartmann, W; Carlier, E; Cornelis, K; Efthymiopoulos, I; Goddard, B; Jensen, L K; Kain, V; Kowalska, M; Mertens, V; Steerenberg, R

    2013-01-01

    The Long Straight Section 2 (LSS2) of the CERN SPS is connected with the North Area (NA), to which the beam to date has always been extracted using a resonant extraction technique. For new proposed short- and long-baseline neutrino experiments, a fast single turn extraction to this experimental area is required. As there are no kickers in LSS2, and the integration of any new kickers with the existing electrostatic septum would be problematic, a solution has been developed to fast extract the beam using non-local extraction with other SPS kickers. Two different kicker systems have been used, the injection kicker in LSS1 and the stronger extraction kicker in LSS6 to extract 100 and 440 GeV beam, respectively. For both solutions a large emittance beam was extracted after 5 or 9 full betatron periods. The concept and simulation details are presented with the analysis of the aperture and beam loss considerations and experimental results collected during a series of beam tests.

  10. Full-turn symplectic map from a generator in a Fourier-spline basis

    International Nuclear Information System (INIS)

    Berg, J.S.; Warnock, R.L.; Ruth, R.D.; Forest, E.

    1993-04-01

    Given an arbitrary symplectic tracking code, one can construct a full-turn symplectic map that approximates the result of the code to high accuracy. The map is defined implicitly by a mixed-variable generating function. The implicit definition is no great drawback in practice, thanks to an efficient use of Newton's method to solve for the explicit map at each iteration. The generator is represented by a Fourier series in angle variables, with coefficients given as B-spline functions of action variables. It is constructed by using results of single-turn tracking from many initial conditions. The method has been appliedto a realistic model of the SSC in three degrees of freedom. Orbits can be mapped symplectically for 10 7 turns on an IBM RS6000 model 320 workstation, in a run of about one day

  11. Diamond-turning HP-21 beryllium to achieve an optical surface

    International Nuclear Information System (INIS)

    Allen, D.K.; Hauschildt, H.W.; Bryan, J.B.

    1975-01-01

    Investigation of diamond turning on beryllium was made in anticipation of obtaining an optical finish. Although results of past experiences were poor, it was decided to continue diamond turning on beryllium beyond initial failures. By changing speed and using coolant, partial success was achieved. Tool wear was the major problem. Tests were made to establish and plot wear as a function of cutting speed and time. Slower speeds did cause lower wear rates, but at no time did wear reach an acceptable level. The machine, tools, and procedure used were chosen based on the results of preliminary attempts and on previous experience. It was unnecessary to use an air-bearing spindle because tool failure governed the best finish that could be expected. All tools of diamond composition, whether single crystal or polycrystalline, wore at unacceptable rates. Based on present technology, it must be concluded that beryllium cannot be feasibly diamond turned to achieve an optical finish. (22 fig.)

  12. Characterization of beta-turn and Asx-turns mimicry in a model peptide: stabilization via C--H . . . O interaction.

    Science.gov (United States)

    Thakur, A K; Kishore, R

    2006-04-15

    The chemical synthesis and single-crystal X-ray diffraction analysis of a model peptide, Boc-Thr-Thr-NH2 (1) comprised of proteinogenic residues bearing an amphiphilic Cbeta -stereogenic center, has been described. Interestingly, the analysis of its molecular structure revealed the existence of a distinct conformation that mimics a typical beta-turn and Asx-turns, i.e., the two Thr residues occupy the left- and right-corner positions. The main-chain torsion angles of the N- and C-terminal residues i.e., semiextended: phi = -68.9 degrees , psi = 128.6 degrees ; semifolded: phi = -138.1 degrees , psi = 2.5 degrees conformations, respectively, in conjunction with a gauche- disposition of the obligatory C-terminus Thr CgammaH3 group, characterize the occurrence of the newly described beta-turn- and Asx-turns-like topology. The preferred molecular structure is suggested to be stabilized by an effective nonconventional main-chain to side-chain Ci=O . . . H--Cgamma(i+2)-type intraturn hydrogen bond. Noteworthy, the observed topology of the resulting 10-membered hydrogen-bonded ring is essentially similar to the one perceived for a classical beta-turn and the Asx-turns, stabilized by a conventional intraturn hydrogen bond. Considering the signs as well as magnitudes of the backbone torsion angles and the orientation of the central peptide bond, the overall mimicked topology resembles the type II beta-turn or type II Asx-turns. An analysis of Xaa-Thr sequences in high-resolution X-ray elucidated protein structures revealed the novel topology prevalence in functional proteins (unpublished). In view of indubitable structural as well as functional importance of nonconventional interactions in bioorganic and biomacromolecules, we intend to highlight the participation of Thr CgammaH in the creation of a short-range C=O . . . H--Cgamma -type interaction in peptides and proteins. Copyright 2006 Wiley Periodicals, Inc.

  13. Spatiotemporal and Kinematic Parameters Relating to Oriented Gait and Turn Performance in Patients with Chronic Stroke.

    Directory of Open Access Journals (Sweden)

    Céline Bonnyaud

    Full Text Available The timed up and go test (TUG is a functional test which is increasingly used to evaluate patients with stroke. The outcome measured is usually global TUG performance-time. Assessment of spatiotemporal and kinematic parameters during the Oriented gait and Turn sub-tasks of the TUG would provide a better understanding of the mechanisms underlying patients' performance and therefore may help to guide rehabilitation. The aim of this study was thus to determine the spatiotemporal and kinematic parameters which were most related to the walking and turning sub-tasks of TUG performance in stroke patients.29 stroke patients carried out the TUG test which was recorded using an optoelectronic system in two conditions: spontaneous and standardized condition (standardized foot position and instructed to turn towards the paretic side. They also underwent a clinical assessment. Stepwise regression was used to determine the parameters most related to Oriented gait and Turn sub-tasks. Relationships between explanatory parameters of Oriented gait and Turn performance and clinical scales were evaluated using Spearman correlations.Step length and cadence explained 82% to 95% of the variance for the walking sub-tasks in both conditions. Percentage single support phase and contralateral swing phase (depending on the condition respectively explained 27% and 56% of the variance during the turning sub-task in the spontaneous and standardized conditions.Step length, cadence, percentage of paretic single support phase and non-paretic swing phase, as well as dynamic stability were the main parameters related to TUG performance and they should be targeted in rehabilitation.

  14. AE Monitoring of Diamond Turned Rapidly Soldified Aluminium 443

    International Nuclear Information System (INIS)

    Onwuka, G; Abou-El-Hossein, K; Mkoko, Z

    2017-01-01

    The fast replacement of conventional aluminium with rapidly solidified aluminium alloys has become a noticeable trend in the current manufacturing industries involved in the production of optics and optical molding inserts. This is as a result of the improved performance and durability of rapidly solidified aluminium alloys when compared to conventional aluminium. Melt spinning process is vital for manufacturing rapidly solidified aluminium alloys like RSA 905, RSA 6061 and RSA 443 which are common in the industries today. RSA 443 is a newly developed alloy with few research findings and huge research potential. There is no available literature focused on monitoring the machining of RSA 443 alloys. In this research, Acoustic Emission sensing technique was applied to monitor the single point diamond turning of RSA 443 on an ultrahigh precision lathe machine. The machining process was carried out after careful selection of feed, speed and depths of cut. The monitoring process was achieved with a high sampling data acquisition system using different tools while concurrent measurement of the surface roughness and tool wear were initiated after covering a total feed distance of 13km. An increasing trend of raw AE spikes and peak to peak signal were observed with an increase in the surface roughness and tool wear values. Hence, acoustic emission sensing technique proves to be an effective monitoring method for the machining of RSA 443 alloy. (paper)

  15. CERN's Community "Log Book" turns 50

    CERN Document Server

    Katarina Anthony

    2015-01-01

    For five decades, the CERN Bulletin has been a staple of the Organization. As CERN has grown as a laboratory and a community, the Bulletin has been there to cover each development as it happens. In honour of the publication's 50th anniversary, we're taking a trip through CERN’s history via the headings and hidden corners of its internal newsletter.     It's 1965 and CERN - now 11 years old - has matured from a simple lab to a fledgling community. While news could once spread in a single afternoon, CERN's growth necessitated a new approach to the sharing of internal information. Meanwhile, the CERN Courier - the only publication in town - was approaching a more global physics audience – an audience for whom CERN road closures were not breaking news. And so, in March 1965, the Weekly Bulletin was born. What was meant as a simple newsletter of events and internal announcements quickly developed into a wider source of news about CERN....

  16. Mechanisms for turn alternation in four invertebrate species.

    Science.gov (United States)

    Hughes, R N

    1987-02-01

    Free-choice behavior following one or more forced turns was observed in representatives of four invertebrate classes (earthworms, woodlice, millipedes, earwigs). While all animals alternated, species differences occurred in free turn angle and the effects of varied angle and number of forced turns. Overall, woodlice and millipedes turned at sharper angles and responded more to the forced turn conditions than earthworms and earwigs. From behavior observed following three forced turns in one direction and then one in the opposite, it was concluded that, in earlier experiments, earthworms alternated via tactile cues, woodlice mainly used kinesthetic but could also use tactile cues, millipedes mainly used tactile but could also use kinesthetic cues and earwigs may have relied on kinesthetic cues alone. Since phyletic differences did not seem appropriate, the results were discussed in terms of other characteristics such as body shape and life style. Copyright © 1987. Published by Elsevier B.V.

  17. Protein Extractability

    African Journals Online (AJOL)

    Results showed that protein extractability was dependent on pH, type of salt, salt concentrations and extraction time. Salts extracted more proteins from the moringa seed flour than water. Maximum extraction of protein was. 85.06% and 84.72% with 0.5 M CaCl and 0.75 M NaCl respectively. On varying the pH, maximum ...

  18. Laterality of the lower limbs and carving turns

    Directory of Open Access Journals (Sweden)

    F Vaverka

    2010-06-01

    Full Text Available The aim of this study is to discover whether the lateral preference of the lower limbs influences the execution of successive carving turns or not. Six skilled skiers (men, right lower limb preference, age 26.5±1.61 years old, height 1.80±0.04 m, body weight 78.83±5.46 kg executed 30 (18 left, 12 right symmetrical carving turns. Kinetic analysis of the final vertical component of reaction force FZ(t measured dynamometrically provided the information about the time of initiation and steering phases of the turn and the maximum force, average force and force impulse. Differences between right and left turns are not statistically significant. Factual analyses of the magnitude of measured variables confirmed that left turns were found to have a longer duration, a shorter initiation and longer steering phase, and higher level of produced force and force impulse in comparison with right turns. Based on the results it can be concluded that the turns where the outer leg is the preferred limb are preferentially used to regulate the speed of the ride. The study of laterality in symmetrical carving turns has proven that lateral preference of lower extremities influences the execution of the turn also by expert skiers.

  19. Injection and extraction for cyclotrons

    CERN Document Server

    Kleeven, W

    2006-01-01

    The main design goals for beam injection are explained and special problems related to a central region with internal ion source are considered. The principle of a PIG source is addressed. The issue of vertical focusing in the cyclotron centre is briefly discussed. Several examples of numerical simulations are given. Different ways of (axial) injection are briefly outlined. A proposal for a magnetostatic axial inflector is given. Different solutions for beam extraction are treated. These include the internal target, extraction by stripping, resonant extraction using a deflector and self-extraction. The different ways of creating a turn-separation are explained. The purpose of different types of extraction devices such as harmonic coils, deflectors and gradient corrector channels are outlined. Several illustrations are given in the form of photographs and drawings.

  20. DESIGN AND INITIAL RESULTS OF A TURN-BY-TURN BEAM POSITION MONITORING SYSTEM FOR MULTIPLE BUNCH OPERATION OF THE ATF DAMPING RING

    CERN Document Server

    Christian, G B; Bett, D R; Burrows, P N; Davis, M R; Gerbershagen, A; Perry, C; Constance, B; Resta-Lopez, J

    2011-01-01

    An FPGA-based monitoring system has been developed to study multi-bunch beam instabilities in the damping ring (DR) of the KEK Accelerator Test Facility (ATF), utilising a stripline beam position monitor (BPM) and existing BPM processor hardware. The system is designed to record the horizontal and/or vertical positions of up to three bunches in the DR in single-bunch multi-train mode or the head bunch of up to three trains in multi-bunch mode, with a bunch spacing of 5.6 ns. The FPGA firmware and data acquisition software were modified to record turn-by-turn data for up to six channels and 1–3 bunches in the DR. An overview of the system and initial results will be presented.

  1. The performative turn at Inhotim: installation art and Baudelairean modernity

    Directory of Open Access Journals (Sweden)

    Lauren S. Weingarden

    2013-12-01

    Full Text Available This article explores the participatory turn in installation art as part of a trajectory from Baudelairean modernity to twentyfirst-century postmodernity, as represented at Inhotim, the outdoor contemporary art museum and botanical gardens in Brumadinho, MG. In his 1862 essay “The Painter of ModernLife,” Charles Baudelaire defined modernity as fleeting, transitory and fragmentary. Baudelairean modernity initiated a breakdown of boundaries between art and life and between high art aesthetics and popular culture, which continues in the work of installation artists. In the sites of installation art, the spectator is compelled to extend – rather than complete – the work of art in his/her own time, prior experiential encounters and transformative after thoughts.The shift from the isolated work of art to the experiential one notonly complicates how and where works of art are viewed, but also radicalizes the materials that constitute the work of art – whether those materials are extracted from the quotidian sphere or complex technologies, each undergoes a process of defamiliarization and reactivation to produce the transformative aesthetic experience.The individual installations in Inhotim’s “outdoor museum” engage the spectator in a dynamic/participatory experience with spatial,temporal and material relationships that define the very essence of art’s reciprocity, or contrast with the natural and man-madeworlds. It is the rarefied setting of Inhotim’s botanical gardens that makes the participatory and transformative experience central to the aesthetic encounter with installation art.

  2. Single post-extractive ultra-wide 7 mm-diameter implants versus implants placed in molar healed sites after socket preservation for molar replacement: 6-month post-loading results from a randomised controlled trial.

    Science.gov (United States)

    Tallarico, Marco; Xhanari, Erta; Pisano, Milena; De Riu, Giacomo; Tullio, Antonio; Meloni, Silvio Mario

    To test the hypothesis that there is no difference in clinical, radiographic and aesthetic outcomes positioning single post-extractive ultra-wide 7 mm-diameter implants or waiting 4 months to place implant, after molar extraction and the socket preservation procedure. Patients requiring one implant-supported single restoration to replace a failed tooth in the molar region of both maxilla and mandible were selected. Patients were randomised according to a parallel group design into two arms: implant installation in fresh extraction sockets augmented with corticocancellous heterologous bone and porcine derma (group A) or delayed implant installation 4 months after tooth extraction and socket preservation using the same materials (group B). Ultra-wide 7 mm-diameter implants were submerged for 4 months. Outcome measures were implant success and survival; complications; horizontal dimensional changes measured on cone beam computed tomography (CBCT) scans at three levels, localised 1, 2 and 3 mm below the most coronal aspect of the bone crest (level A, B and C); peri-implant marginal bone level changes; implant stability quotient (ISQ); and pink esthetic score (PES). Twelve patients were randomised to group A and 12 to group B. No patients dropped out. No implant failed or complications occurred up to 6-months post-loading. Six months after loading there was more horizontal alveolar bone reduction at immediate post-extractive implants, which was statistically significant. At level A was 1.78 mm ± 1.30 in group A, 0.45 mm ± 0.42 in group B, (difference 1.33 mm ± 1.39; 95% CI: 0.38 to 1.95; P = 0.003); at level B was 0.98 mm ± 1.13 in group A, 0.14 mm ± 0.22 in group B, (difference 0.84 mm ± 1.16; 95% CI: 0.24 to 1.07; P = 0.019); at level C was 0.55 mm ± 0.74 in group A, 0.03 mm ± 0.24 in group B, (difference 0.51 mm ± 0.76, 95% CI: 0.01 to 0.87; P = 0.032). One year after implant

  3. Vacuum extraction

    DEFF Research Database (Denmark)

    Nielsen, Mathilde Maagaard; Oestergaard, Jeanett; Johansen, Marianne

    2012-01-01

    Objectives. To develop and validate an Objective Structured Assessment of Technical Skills (OSATS) scale for vacuum extraction. Design. Two part study design: Primarily, development of a procedure-specific checklist for vacuum extraction. Hereafter, validationof the developed OSATS scale for vacuum...... with daily work in the obstetric field were tested. Methods. The Delphi method was used for development of the scale. In a simulated vacuum extraction scenario first-year residents and obstetric chief physicians were rated using the developed OSATS scale for vacuum extraction to test construct validity...... scale for vacuum extraction is a reliable test for differentiating between competence levels in a simulated setting....

  4. A Single-Center, Randomized, Double-Blind, Placebo-Controlled Clinical Trial of the Effectiveness of ANT1 Soybean Extract Cream on Skin Recovery After Nd: YAG Laser Treatment.

    Science.gov (United States)

    Hsieh, Meng-Chien; Wu, Yi-Chia; Huang, Shu-Hung; Kuo, Yur-Ren; Lee, Su-Shin

    2018-02-01

    Nd:YAG laser has been used extensively for its versatility in treating many common aesthetic problems, but numerous adverse effects are often complained by recipients of Nd:YAG laser. This study introduces the ANT1 soybean extract cream, which was formulated to alleviate adverse effects after laser therapy. This study explores whether ANT1 enhances the repair mechanism of the postlaser skin, decreases laser-induced complication, and shortens recovery time. The study also aims to pinpoint the ANT1 concentration that is most effective in improving the skin condition after Nd-YAG laser therapy. This study was a single-center, randomized, double-blind, placebo-controlled trial. Patients eligible for the study were Asian women, aged 25 to 40 years, who were free of dermatological diseases and allergic reaction. There were a total of 45 subjects. Each subject received a session of Nd-YAG laser therapy every 2 weeks, totaling 3 sessions. Facial skin assessment was achieved via VISIA complexion analysis. VISIA complexion analysis quantitatively assessed the skin condition and tracked the recovery progress of each subject at baseline, immediately after all 3 laser sessions, and a week after the final laser treatment. Skin condition was evaluated by VISIA complexion analysis. Skin condition was recorded in aspects of pigmented spots, wrinkles, texture, pores, and red area. After Nd-YAG laser therapy, postlaser inflammation was observed in all subjects. Throughout the laser sessions and the outpatient follow-up clinic, the adverse effects of laser therapy, such as redness, spots, wrinkles, pores, and textures, decreased with the use of ANT1 cream. There has been a marked effect in wrinkle reduction in the patients who received a higher concentration of ANT1 cream (P ≤ 0.05). Statistically significant improvement in spots and pores is also seen (P ≤ 0.05). Through this study, the results suggest that the application of ANT1 soybean extract cream ameliorates the

  5. "Turn-off" fluorescent data array sensor based on double quantum dots coupled with chemometrics for highly sensitive and selective detection of multicomponent pesticides.

    Science.gov (United States)

    Fan, Yao; Liu, Li; Sun, Donglei; Lan, Hanyue; Fu, Haiyan; Yang, Tianming; She, Yuanbin; Ni, Chuang

    2016-04-15

    As a popular detection model, the fluorescence "turn-off" sensor based on quantum dots (QDs) has already been successfully employed in the detections of many materials, especially in the researches on the interactions between pesticides. However, the previous studies are mainly focused on simple single track or the comparison based on similar concentration of drugs. In this work, a new detection method based on the fluorescence "turn-off" model with water-soluble ZnCdSe and CdSe QDs simultaneously as the fluorescent probes is established to detect various pesticides. The fluorescence of the two QDs can be quenched by different pesticides with varying degrees, which leads to the differences in positions and intensities of two peaks. By combining with chemometrics methods, all the pesticides can be qualitative and quantitative respectively even in real samples with the limit of detection was 2 × 10(-8) mol L(-1) and a recognition rate of 100%. This work is, to the best of our knowledge, the first report on the detection of pesticides based on the fluorescence quenching phenomenon of double quantum dots combined with chemometrics methods. What's more, the excellent selectivity of the system has been verified in different mediums such as mixed ion disruption, waste water, tea and water extraction liquid drugs. Copyright © 2016 Elsevier B.V. All rights reserved.

  6. CONNECTION OF TURN AHEAD AND TURN BACK WITH MOTORIC ABILITIES OF THE FOURTH GRADE OF HIGH SCHOOL

    Directory of Open Access Journals (Sweden)

    Jovica Petković

    2008-08-01

    Full Text Available The research is done for the purpose of determination and defining of the level of connection between some motoric abilities with success in realization of programmed contents from the area of gymnastics (turn ahead and turn back. The research is done on the sample of fifty students from the fourth grade of High School, on ten motoric tests and on two specific motoric assignments – turn ahead and turn back. The results of this research clearly point that there exist the multitude of statistically important coefficients of correlation between treated motoric abilities and applied motoric assignments.

  7. Costs of switching auditory spatial attention in following conversational turn-taking

    OpenAIRE

    Lin, Gaven; Carlile, Simon

    2015-01-01

    Following a multi-talker conversation relies on the ability to rapidly and efficiently shift the focus of spatial attention from one talker to another. The current study investigated the listening costs associated with shifts in spatial attention during conversational turn-taking in 16 normally-hearing listeners using a novel sentence recall task. Three pairs of syntactically fixed but semantically unpredictable matrix sentences, recorded from a single male talker, were presented concurrently...

  8. The Benefits of Single-Touch Screens in Intersubjective Meaning Making

    DEFF Research Database (Denmark)

    Davidsen, Jacob; Christiansen, Ellen Tove

    2013-01-01

    What are the benefits of single-touch screens? The paper presents findings of one video extract from ten months of observation of single-touch screen interaction among 8-9 year-old children. Recent studies of collaborative learning mediated by digital touch screens and tabletops emphasize...... the possibilities for equal levels of verbal and physical participation.Additionally, these studies suggest that multi-touch technologies offer more task-oriented activities compared to single-touch screen interaction, in which discussion about turn-taking is more prevalent from the outset. In contrast, applying...... the Embodied Interaction Analysis, we find that the constraints of single-touch screens offer support for intersubjective meaning making in their capacity of constraining the interaction. This “grain of sand” shows how children display and construct a shared work space through embodied interaction...

  9. Density of Plutonium Turnings Generated from Machining Activities

    Energy Technology Data Exchange (ETDEWEB)

    Gonzales, John Robert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Vigil, Duane M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Jachimowski, Thomas A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Archuleta, Alonso [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Arellano, Gerald Joseph [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Melton, Vince Lee [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-10-20

    The purpose of this project was to determine the density of plutonium (Pu) turnings generated from the range of machining activities, using both surrogate material and machined Pu turnings. Verify that 500 grams (g) of plutonium will fit in a one quart container using a surrogate equivalent volume and that 100 grams of Pu will fit in a one quart Savy container.

  10. Cutting forces during turning with variable depth of cut

    Directory of Open Access Journals (Sweden)

    M. Sadílek

    2016-03-01

    The proposed research for the paper is an experimental work – measuring cutting forces and monitoring of the tool wear on the cutting edge. It compares the turning where standard roughing cycle is used and the turning where the proposed roughing cycle with variable depth of cut is applied.

  11. Quasi-Automatic Monitoring System For Turning Operation Using ...

    African Journals Online (AJOL)

    This work discusses the generation of a quasi monitoring system intended for an operator to change cutting tool during turning operation. The monitoring system uses the effects of turning va riables on acoustic emission signal responses and factorial experimental design approach. In cutting operations, acoustic emission ...

  12. Turn-Continuation by Self and by Other

    Science.gov (United States)

    Sidnell, Jack

    2012-01-01

    At the possible completion of a turn constructional unit (TCU) that has not selected a next speaker, a speaker has two available options: either begin a new TCU or continue the one that has just come to a point of possible completion. This article describes some of the complex turns that result from exercising the second option. These can be seen…

  13. Fast Turn-off Mine Transient Electromagnetic Transmitter System

    Directory of Open Access Journals (Sweden)

    ZHENG Xiao-Liang

    2014-05-01

    Full Text Available For solving problems such as short turn-off time, high linear degree of falling edge, measurement of turn-off time and influence of primary signals for transient electromagnetic transmitter, and restrictions because of the environmental conditions of underground coal mine, this thesis aims at designing a new transient electromagnetic transmitter system suitable for coal mine. Supported by damping absorption circuit, such system applies small volume, sectional transmitting coil, with features of short turn-off time, high linear degree of current falling edge. It uses the transmitter monitoring circuit, which accurately measures turn-off time and simultaneously records the current value changes after turn-off, thus to eliminate the influence of primary field as well as to restore earlier secondary field signals for reference and finally to improve the ability to detect the shallow structure. It turns out that the new system has a shorter turn-off time, a higher linear degree of current falling and more accurate data record of turn-off current.

  14. Wittgenstein and the linguistic turn in social theory

    DEFF Research Database (Denmark)

    Hermansen, Jens Christian

    of Winch in social theory, the wider and more recent influence of Wittgenstein in areas such as technology and science studies, social theory, feminist and gender studies and conversation and discourse analysis is also considered. Historically, the readings of Wittgenstein in the social sciences have taken...... the implications of Wittgenstein's philosophy to involve three general theses (what I shall call the three theses of the linguistic turn). According to these (a) social life is organised in and through language (the linguistic thesis), (b) language is a practical activity, a language-in-use (the practical thesis...... of the linguistic turn in social theory, the linguistic turn is a double-edged sword of both profound insights and limits; the claim is that the limits of the linguistic turn are the strengths of functionalist, structuralist and materialist approaches to the social sciences. The approach of the critical turn...

  15. Multi-turn Extraction system of the PS at CERN: information management and planning

    OpenAIRE

    Vergara Fernández, Rocío

    2007-01-01

    CERN es el Consejo Europeo de la Investigación Nuclear. Es el mayor laboratorio de física de partículas, donde científicos de todo el mundo estudian la estructura de la materia y las fuerzas que las mantienen unidas para así conseguir entender mejor el comportamiento y el origen del Universo. Actualmente se está construyendo el mayor acelerador del mundo (ya en su fase de puesta en marcha), el Large Hadron Collider (LHC) situado en la frontera franco-suiza, ocupando un túnel 27...

  16. A general design for coherent transponders with multiple turn-around ratios

    Science.gov (United States)

    Li, Minzhu; Yang, Zhen; Ye, Lei; Zhou, Rong; Guo, Kenping

    2017-10-01

    A general design is proposed to meet the miniaturization requirement for coherent transponders with multiple turn-around ratios. The transponder can be realized with a single LO and a single frequency conversion for both directions, by unifying different LOs, sharing TR channels, and expanding the processing bandwidth of digital circuits, which accords with the idea of software defined radio(SDR) and replace the traditional LOs in intermediate frequency(IF) for frequency up or down conversion. This design is convenient for chip integration and channel expanding, and can be utilized as a general platform for similar transceivers.

  17. Vibration Sensor Monitoring of Nickel-Titanium Alloy Turning for Machinability Evaluation

    Directory of Open Access Journals (Sweden)

    Tiziana Segreto

    2017-12-01

    Full Text Available Nickel-Titanium (Ni-Ti alloys are very difficult-to-machine materials causing notable manufacturing problems due to their unique mechanical properties, including superelasticity, high ductility, and severe strain-hardening. In this framework, the aim of this paper is to assess the machinability of Ni-Ti alloys with reference to turning processes in order to realize a reliable and robust in-process identification of machinability conditions. An on-line sensor monitoring procedure based on the acquisition of vibration signals was implemented during the experimental turning tests. The detected vibration sensorial data were processed through an advanced signal processing method in time-frequency domain based on wavelet packet transform (WPT. The extracted sensorial features were used to construct WPT pattern feature vectors to send as input to suitably configured neural networks (NNs for cognitive pattern recognition in order to evaluate the correlation between input sensorial information and output machinability conditions.

  18. Vibration Sensor Monitoring of Nickel-Titanium Alloy Turning for Machinability Evaluation.

    Science.gov (United States)

    Segreto, Tiziana; Caggiano, Alessandra; Karam, Sara; Teti, Roberto

    2017-12-12

    Nickel-Titanium (Ni-Ti) alloys are very difficult-to-machine materials causing notable manufacturing problems due to their unique mechanical properties, including superelasticity, high ductility, and severe strain-hardening. In this framework, the aim of this paper is to assess the machinability of Ni-Ti alloys with reference to turning processes in order to realize a reliable and robust in-process identification of machinability conditions. An on-line sensor monitoring procedure based on the acquisition of vibration signals was implemented during the experimental turning tests. The detected vibration sensorial data were processed through an advanced signal processing method in time-frequency domain based on wavelet packet transform (WPT). The extracted sensorial features were used to construct WPT pattern feature vectors to send as input to suitably configured neural networks (NNs) for cognitive pattern recognition in order to evaluate the correlation between input sensorial information and output machinability conditions.

  19. Extraction method

    International Nuclear Information System (INIS)

    Stary, J.; Kyrs, M.; Navratil, J.; Havelka, S.; Hala, J.

    1975-01-01

    Definitions of the basic terms and of relations are given and the knowledge is described of the possibilities of the extraction of elements, oxides, covalent-bound halogenides and heteropolyacids. Greatest attention is devoted to the detailed analysis of the extraction of chelates and ion associates using diverse agents. For both types of compounds detailed conditions are given of the separation and the effects of the individual factors are listed. Attention is also devoted to extractions using mixtures of organic agents, the synergic effects thereof, and to extractions in non-aqueous solvents. The effects of radiation on extraction and the main types of apparatus used for extractions carried out in the laboratory are described. (L.K.)

  20. Multiturn Extraction Based on Trapping in Stable Islands at CERN PS: Recent Measurement Advances

    CERN Multimedia

    Cappi, R; Giovannozzi, Massimo; Martini, M; Métral, Elias; Müller, A S; Sakumi, A; Steerenberg, R

    2004-01-01

    Recently a novel approach to perform multi-turn extraction was proposed based on beam splitting in the transverse phase space by means of trapping inside stable islands. During the year 2002, preliminary measurements at the CERN Proton Synchrotron with a low-intensity, singlebunch, proton beam, confirmed the possibility of generating various beamlets starting from a single Gaussian beam. The experimental campaign continued also during the year 2003 to assess a number of key issues, such as the feasibility of trapping with high-intensity beam and capture efficiency. The experimental results are presented and discussed in detail in this paper.

  1. Sharp Turning and Corner Turning: Comparison of Energy Expenditure, Gait Parameters, and Level of Fatigue among Community-Dwelling Elderly

    Directory of Open Access Journals (Sweden)

    Maria Justine

    2014-01-01

    Full Text Available This study compares energy expenditure (EE, gait parameters (GP, and level of fatigue (LOF between 5-minute walking with sharp turning (ST and corner turning (CT. Data were obtained from 29 community-dwelling elderly (mean age, 62.7 ± 3.54 years. For 5 minutes, in ST task, participants walked on a 3-meter pathway with 2 cones placed at each end (180° turning, while in CT task, participants walked on a 6-meter pathway with 4 cones placed at 4 corners (90° turning. The physiological cost index, pedometer, and 10-point Modified Borg Dyspnoea Scale were used to measure EE (beats/min, GP (no of steps, and LOF, respectively. Data were analyzed by using independent t-tests. EE during ST (0.62 ± 0.21 beats/min was significantly higher than CT (0.48 ± 0.17 beats/min (P0.05. Higher EE in ST could be due to the difficulty in changing to a 180° direction, which may involve agility and different turning strategies (step-turn or pivot-turn to adjust the posture carefully. In CT, participants could choose a step-turn strategy to change to a 90° direction, which was less challenging to postural control.

  2. Determination of coupled-lattice properties using turn-by-turn data

    International Nuclear Information System (INIS)

    Bourianoff, G.; Hunt, S.; Mathieson, D.; Pilat, F.; Talman, R.; Morpurgo, G.

    1992-01-01

    A formalism for extracting coupled betatron parameters from multiturn, shock excited, beam position monitor data is described. The most important results are nonperturbative in that they do not rely on the underlying ideal lattice model. Except for damping, which is assumed to be exponential and small enough to be removed empirically, the description is symplectic. As well as simplifying the description, this leads to self-consistency checks that are applied to the data. The most important of these is a ''magic ratio'' of Fourier coefficients that is required to be a lattice invariant, the same at every beam position monitor. All formulas are applied to both real and simulated data. The real data were acquired June 1992 at LEP as part of decoupling studies, using the LEP beam orbit measurement system. Simulated data, obtained by numerical tracking (TEAPOT) in the same (except for unknown errors) lattice, agrees well with real data when subjected to identical analysis. For both datasets, deviations between extracted and design parameters and deviations from self-consistency can be accounted for by noise and signal-processing limitations. This investigation demonstrates that the LEP beam position system yields reliable local coupling measurements. It can be conservatively assumed that systems of similar design at the SSC and LHC will provide the measurements needed for local decoupling

  3. Determination of coupled-lattice properties using turn-by-turn data

    International Nuclear Information System (INIS)

    Bourianoff, G.; Hunt, S.; Mathieson, D.

    1992-12-01

    A formalism for extracting coupled betatron parameters from multiturn, shock excited, beam position monitor data is described. The most important results are nonperturbative in that they do not rely on the underlying ideal lattice model. Except for damping, which is assumed to be exponential and small enough to be removed empirically, the description is symplectic. As well as simplifying the description, this leads to self-consistency checks that are applied to the data. The most important of these is a open-quotes magic ratioclose quotes of Fourier coefficients that is required to be a lattice invariant, the same at every beam position monitor. All formulas are applied to both real and simulated data. The real data was acquired June, 1992 at LEP as part of decoupling studies, using the LEP beam orbit measurement system. Simulated data, obtained by numerical tracking (TEAPOT) in the same (except for unknown errors) lattice, agrees well with real data when subjected to identical analysis. For both datasets, deviations between extracted and design parameters and deviations from self-consistency can be accounted for by noise and signal processing limitations. This investigation demonstrates that the LEP beam position system yields reliable local coupling measurements. It can be conservatively assumed that systems of similar design at the SSC and LHC will provide the measurements needed for local decoupling

  4. Observation of diamond turned OFHC copper using Scanning Tunneling Microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Grigg, D.A.; Russell, P.E.; Dow, T.A.

    1988-12-01

    Diamond turned OFHC copper samples have been observed within the past few months using the Scanning Tunneling Microscope. Initial results have shown evidence of artifacts which may be used to better understand the diamond turning process. The STM`s high resolution capability and three dimensional data representation allows observation and study of surface features unobtainable with conventional profilometry systems. Also, the STM offers a better quantitative means by which to analyze surface structures than the SEM. This paper discusses findings on several diamond turned OFHC copper samples having different cutting conditions. Each sample has been cross referenced using STM and SEM.

  5. APPLIANCE OF COMPETITORS TECHNIQUES IN LEADING THE SKIES IN TURNING

    Directory of Open Access Journals (Sweden)

    Rašid Hadžić

    2009-11-01

    Full Text Available Competitors techniques in skiing characterize driving on edges, without gliding in certain fazes of turning. Today that characteristic is more and more present in all di- scipline, (downhill, super G, giant slalom and slalom so we can talk about appliance of basic technique of leading skies on all disciplines, with differences in position of skies in amplitude of moving and frequencies of changes of edges. From that point of view we distinct three typical shape of moving in turning, which have mutual distinction in influence on ski loading, and that has influence on tur- ning line and acceleration or checking in certain fazes of turning.

  6. Beam polarization during a Siberian snake turn-on

    International Nuclear Information System (INIS)

    Anferov, Vladimir A.

    1999-01-01

    Installing Siberian snakes in a circular proton accelerator allows one to overcome all spin depolarizing resonances even at very high energies. However, Siberian snake application at low energies is technically rather difficult. Turning snake on at some energy during acceleration would allow using Siberian snakes even in rings with low injection energies. It is shown that the beam polarization would be preserved during the snake ramp, provided that the snake is turned on in more than ten turns, and the energy is set near a half-integer Gγ

  7. Electromembrane extraction

    DEFF Research Database (Denmark)

    Huang, Chuixiu; Chen, Zhiliang; Gjelstad, Astrid

    2017-01-01

    Electromembrane extraction (EME) was inspired by solid-phase microextraction and developed from hollow fiber liquid-phase microextraction in 2006 by applying an electric field over the supported liquid membrane (SLM). EME provides rapid extraction, efficient sample clean-up and selectivity based ...

  8. Differences of ballet turns (pirouette) performance between experienced and novice ballet dancers.

    Science.gov (United States)

    Lin, Chia-Wei; Chen, Shing-Jye; Su, Fong-Chin; Wu, Hong-Wen; Lin, Cheng-Feng

    2014-09-01

    This study investigated the different postural control strategies exhibited by experienced and novice dancers in ballet turns (pirouettes). Thirteen novice and 13 experienced dancers performed ballet turns with dominant-leg support. The peak push force was measured in the double-leg support phase. The inclination angles of rotation axis with respect to vertical axis were calculated in the early single-leg support phase as well as the initiation sequence of ankle, knee, and hip joints on the supporting leg. Moreover, the anchoring index of the head was computed in the transverse plane during turning. The novice dancers applied a greater push force, an increased inclination angle of rotation axis, and an insufficient proximal-to-distal extension sequence pattern. The novice dancers also had a smaller head-anchoring index compared with experienced dancers, which meant novice dancers were not using a space target as a stability reference. A poorer performance in novice dancers could result from higher push force in propulsion, lack of a "proximal-to-distal extension sequence" pattern, and lack of visual spotting for postural stability. Training on sequential initiation of lower-extremity joints and rehearsal of visual spotting are essential for novice dancers to obtain better performance on ballet turns.

  9. When the Stakes Turn Toxic: Learn about Problem Gambling

    Science.gov (United States)

    ... 2011 Print this issue When the Stakes Turn Toxic Learn About Problem Gambling Send us your comments ... gambling. you lose a job, educational opportunity or relationship because of gambling. you find that no matter ...

  10. ANALYSIS OF CHIP FORMATION DURING HARD TURNING THROUGH ACOUSTIC EMISSION

    Directory of Open Access Journals (Sweden)

    Miroslav Neslušan

    2012-01-01

    Full Text Available The paper deals with analysis of chip formation and related aspects of the chip formation during turning hardened steel 100Cr6. The paper draws a comparison of some aspects of the chip formation between turning annealed and hardened roll bearing steel. The results of the analysis show that there is the formation of a segmented chip in the case of hard turning. Frequency of segmentation is very high. A conventional piezoelectric dynamometer limits the frequency response to about 3.5 kHz. On the other hand, the frequency of process fluctuation may by obtained by using accelerometers or acoustic emission. This paper reports about the dynamic character of cutting process when hard turning and correlation among the calculated segmentation frequencies and the experimental analysis.

  11. Extended phenotype: nematodes turn ants into bird-dispersed fruits

    DEFF Research Database (Denmark)

    Hughes, D P; Kronauer, D J C; Boomsma, J J

    2008-01-01

    A recent study has discovered a novel extended phenotype of a nematode which alters its ant host to resemble ripe fruit. The infected ants are in turn eaten by frugivorous birds that disperse the nematode's eggs.......A recent study has discovered a novel extended phenotype of a nematode which alters its ant host to resemble ripe fruit. The infected ants are in turn eaten by frugivorous birds that disperse the nematode's eggs....

  12. Reducing gait speed affects axial coordination of walking turns.

    Science.gov (United States)

    Forsell, Caroline; Conradsson, David; Paquette, Caroline; Franzén, Erika

    2017-05-01

    Turning is a common feature of daily life and dynamic coordination of the axial body segments is a cornerstone for safe and efficient turning. Although slow walking speed is a common trait of old age and neurological disorders, little is known about the effect of walking speed on axial coordination during walking turns. The aim of this study was to investigate the influence of walking speed on axial coordination during walking turns in healthy elderly adults. Seventeen healthy elderly adults randomly performed 180° left and right turns while walking in their self-selected comfortable pace and in a slow pace speed. Turning velocity, spatiotemporal gait parameters (step length and step time), angular rotations and angular velocity of the head and pelvis, head-pelvis separation (i.e. the angular difference in degrees between the rotation of the head and pelvis) and head-pelvis velocity were analyzed using Wilcoxon signed-rank tests. During slow walking, turning velocity was 15% lower accompanied by shorter step length and longer step time compared to comfortable walking. Reducing walking speed also led to a decrease in the amplitude and velocity of the axial rotation of the head and pelvis as well as a reduced head-pelvis separation and angular velocity. This study demonstrates that axial coordination during turning is speed dependent as evidenced by a more 'en bloc' movement pattern (i.e. less separation between axial segments) at reduced speeds in healthy older adults. This emphasizes the need for matching speed when comparing groups with diverse walking speeds to differentiate changes due to speed from changes due to disease. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Some topics in process planning of rotational turning

    OpenAIRE

    Kundrák, János; Gyáni, Károly; Deszpoth, István; Sztankovics, István

    2014-01-01

    There could be different procedure variants of chip removal by the applied kinematic relations in turning operations. Recently, some research and analysis of these variants have come to the front since turning can replace grinding in precision machining operations due to the development of tools with geometrically defined cutting edge(s) and tool materials, even in machining of hardened surfaces. This frequently occurs in finish machining, therefore the application ...

  14. Antidiabetic and antioxidant effects of Annona muricata (Annonaceae), aqueous extract on streptozotocin-induced diabetic rats.

    Science.gov (United States)

    Florence, Ngueguim Tsofack; Benoit, Massa Zibi; Jonas, Kouamouo; Alexandra, Tchuidjang; Désiré, Dzeufiet Djomeni Paul; Pierre, Kamtchouing; Théophile, Dimo

    2014-02-03

    The leaves of Annona muricata are used in Cameroon to manage diabetes and its complications. The aim of this study was to evaluate the antidiabetic, antioxidant activities and the potential toxicity of aqueous extract of Annona muricata in streptozotocin-induced diabetic rats. Oral administration of Annona muricata aqueous extract (100mg/kg or 200mg/kg) was studied in normal and streptozotocin-induced diabetic rats. In long term treatment, 2 weeks after streptozotocin-induced diabetic rats, animals received plant extract during 28 consecutive days. For a protective effect, extract was administered 3 days prior to streptozotocin exposure and animals were observed 2 weeks without treatment. The plant extract was not effective in normal rats. In diabetic rats, single administration of the extract significantly reduced blood glucose levels by 75% and 58.22% respectively at the dose of 100mg/kg and 200mg/kg as compared to the initial value. Treatment of normal rats 3 days prior to diabetes induction showed that, Annona muricata extract has no effect within 72h following STZ injection. However, after 14 days post-treatment, the extract at the dose of 100mg/kg significantly reduced blood glucose levels as compared with initial value and diabetic control rats. Immunohistochemical staining of pancreatic β-cells of diabetic rats treated with the dose of 100mg/kg expressed strong staining for β-cell compared to diabetic control. In a long-term study daily administration of Annona muricata aqueous extract for 28 days to diabetic rats, reduced blood glucose levels, serum creatinine, MDA, AST, ALT activity, and nitrite levels LDL-cholesterol. Total cholesterol, triglycerides, SOD, and CAT activity contents were restored. These different results show that the antidiabetic activity of Annona muricata aqueous extract can be explained by its hypolipidaemic effect, its antioxidant and protective action on pancreatic β-cells, which in turn improve glucose metabolism. © 2013

  15. Compensations for increased rotational inertia during human cutting turns.

    Science.gov (United States)

    Qiao, Mu; Brown, Brian; Jindrich, Devin L

    2014-02-01

    Locomotion in a complex environment is often not steady state, but unsteady locomotion (stability and maneuverability) is not well understood. We investigated the strategies used by humans to perform sidestep cutting turns when running. Previous studies have argued that because humans have small yaw rotational moments of inertia relative to body mass, deceleratory forces in the initial velocity direction that occur during the turning step, or 'braking' forces, could function to prevent body over-rotation during turns. We tested this hypothesis by increasing body rotational inertia and testing whether braking forces during stance decreased. We recorded ground reaction force and body kinematics from seven participants performing 45 deg sidestep cutting turns and straight running at five levels of body rotational inertia, with increases up to fourfold. Contrary to our prediction, braking forces remained consistent at different rotational inertias, facilitated by anticipatory changes to body rotational speed. Increasing inertia revealed that the opposing effects of several turning parameters, including rotation due to symmetrical anterior-posterior forces, result in a system that can compensate for fourfold changes in rotational inertia with less than 50% changes to rotational velocity. These results suggest that in submaximal effort turning, legged systems may be robust to changes in morphological parameters, and that compensations can involve relatively minor adjustments between steps to change initial stance conditions.

  16. A single-step pesticide extraction and clean-up multi-residue analytical method by selective pressurized liquid extraction followed by on-line solid phase extraction and ultra-high-performance liquid chromatography-tandem mass spectrometry for complex matrices.

    Science.gov (United States)

    Rodrigues, Elsa Teresa; Pardal, Miguel Ângelo; Salgueiro-González, Noelia; Muniategui-Lorenzo, Soledad; Alpendurada, Maria Fátima

    2016-06-24

    Pesticides, a group of compounds linked to human activity, may, when in toxic levels, have a profound effect on water quality, and hence result in adverse consequences to aquatic life and ultimately to human health. Analytical challenges arise when successfully trying to determine these levels in environmental complex matrices. Therefore, fast, simple, sensitive and selective analytical methodologies for multi-residue determination of pesticides (atrazine, azoxystrobin, bentazon, λ-cyhalothrin, penoxsulam and terbuthylazine) in sediment, macrophytes (algae and aquatic plants) and aquatic animals were developed and validated. The established methods were matrix-dependent and were based on Selective Pressurized Liquid Extraction (SPLE) followed by on-line Solid Phase Extraction and Ultra Performance Liquid Chromatography-tandem Mass Spectrometry (on-line SPE-UPLC-ESI-MS/MS). This cutting-edge research methodology uses a small amount of sample, is time saving and reduces the use of organic solvents in compliance with Green Chemistry principles. The analytical features were adequate for all compounds in all studied matrices. The established methodology was applied on real marine samples and no pesticide concentrations above their respective method quantification limits were measured in sediments or aquatic plants. However, terbuthylazine was found in the macroalgae Ulva spp. (108ngg(-1)dw) and all the prospected pesticides were measured above their respective method quantification limits in the bivalve Scrobicularia plana (atrazine: 48ngg(-1)dw, azoxystrobin: 64ngg(-1)dw, bentazon: 33ngg(-1)dw, λ-cyhalothrin: 2531ngg(-1)dw, penoxsulam: 50ngg(-1)dw, and terbuthylazine: 44ngg(-1)dw). Copyright © 2016 Elsevier B.V. All rights reserved.

  17. Effects of ultrasonic vibrations in micro-groove turning.

    Science.gov (United States)

    Zhang, Chen; Guo, Ping; Ehmann, Kornel F; Li, Yingguang

    2016-04-01

    Ultrasonic vibration cutting is an efficient cutting process for mechanical micro-machining. This process can generate intricate surface textures with different geometric characteristics. Micro-grooves/micro-channels are among the most frequently encountered micro-structures and, as such, are the focus of this paper. The effectiveness of both the linear and ultrasonic elliptical vibration-assisted machining technique in micro-groove turning is analyzed and discussed in the paper. The paper first investigates the mechanisms of micro-groove generation induced by the linear and elliptical vibration modes. A simplified cutting force analysis method is given to compare the effectiveness of the two modes in micro-groove turning. The surface roughness of the generated micro-grooves is analyzed next and theoretical expressions are given for the two cases. Finally, micro-groove turning experiments are conducted to compare the influences of the two vibration modes on the cutting forces and the surface roughness. The experimental results show that linear vibration-assisted micro-groove turning leads to better surface roughness as compared to the elliptical vibration-assisted case, while elliptical vibration-assisted micro-groove turning shows advantages in terms of decreasing the cutting forces. Copyright © 2016 Elsevier B.V. All rights reserved.

  18. Breath holding during the turn in competitive swimming.

    Science.gov (United States)

    Craig, A B

    1986-08-01

    Breath holding times were measured during competition and averaged 5.0 sec in the breaststroke events, 4.3 sec in freestyle, 3.7 sec in butterfly, and 3.3 sec in backstroke. These times represented approximately 30% of the total time of swimming breaststroke and freestyle races but only 20% of the time of backstroke and butterfly events. Pulmonary gas exchanges of O2 and CO2 were studied in eight male swimmers during the first turn after the start of a swim and during the third turn after continuous swimming. It was concluded that biomechanical considerations of optimizing a turn are in most circumstances not limited by the increased PCO2 and the decreased PO2 in the alveoli related to the brief period of breath holding. In turns which last longer than about 5.5 s, the swimmers may experience a strong urge to breathe. This "breaking point" sensation is brief and need not compromise the conclusion of a well-executed turn.

  19. FNAL Booster intensity, extraction, and synchronization control for collider operation

    International Nuclear Information System (INIS)

    Ducar, R.J.; Lackey, J.R.; Tawzer, S.R.

    1987-03-01

    Booster operation for collider physics is considerably different than for fixed target operation. Various scenarios for collider physics, machine studies, and P-Bar targeting may require that the intensity vary from 5E10 PPP to 3E12 PPP at a 15 Hertz machine cycle rate. In addition to the normal Booster single turn extraction mode, collider operations require that the Booster inject into the Main Ring a small number of beam bunches for coalescing into a single high intensity bunch. These bunches must be synchronized such that the center bunch arrives in the RF bucket which corresponds to the zero phase of the coalescing cavity. The system implemented has the ability to deliver a precise fraction of the available 84 Booster beam bunches to Main Ring or to the P-Bar Debuncher via the newly installed AP-4 beam line for tune-up and studies. It is required that all of the various intensity and extraction scenarios be accommodated with minimal operator intervention

  20. Fnal booster intensity, extraction, and synchronization control for collider operation

    International Nuclear Information System (INIS)

    Ducar, R.J.; Lackey, J.R.; Tawzer, S.R.

    1987-01-01

    Booster operation for collider physics is considerably different than for fixed target operation. Various scenarios for collider physics, machine studies, and P-Bar targeting may require that the intensity vary from 5E10 PPP to 3E12 PPP at a 15 Hertz machine cycle rate. In addition to the normal Booster single turn extraction mode, collider operations require that the Booster inject into the Main Ring a small number of beam bunches for coalescing into a single high intensity bunch. These bunches must be synchronized such that the center bunch arrives in the RF bucket which corresponds to the zero phase of the coalescing cavity. The system implemented has the ability to deliver a precise fraction of the availability 84 Booster beam bunches to Main Ring or to the P-Bar Debuncher via the newly installed AP-4 beam line for tune-up and studies. It is required that all of the various intensity and extraction scenarios be accommodated with minimal operator intervention

  1. Wittgenstein and the linguistic turn in social theory

    DEFF Research Database (Denmark)

    Hermansen, Jens Christian

    is to develop a more comprehensive social theory that is sensitive to these strengths and thus supersedes the limits of the linguistic turn. This paper suggests a different approach. Against the critical turn, the paper argues that the limits of the linguistic turn are identical with the very assumptions......Historically, the influence of philosopher Peter Winch on the readings of Wittgenstein in the social sciences has been enormous. Though this paper deals mainly with what Winch took to be the implications for the social sciences of Wittgenstein's late philosophy as well as the later critique...... of Winch in social theory, the wider and more recent influence of Wittgenstein in areas such as technology and science studies, social theory, feminist and gender studies and conversation and discourse analysis is also considered. Historically, the readings of Wittgenstein in the social sciences have taken...

  2. Mechanical deflection analysis of diamond-turned reflective optics

    International Nuclear Information System (INIS)

    Stoneking, J.E.; Gerth, H.L.

    1977-12-01

    An analytical technique has been developed that predicts the amount of warpage that metal reflective mirrors sustain due to various support and load conditions. The laser fusion project being conducted at LASL requires that metal reflective optics be fabricated by diamond turning. The diamond-turning process imposes some unusual loading conditions which result in mirror warpage. The finite-element method is used to compute mirror surface displacements resulting from these support and load conditions. Surface warpage is then determined by a best-fit comparison of these data to the desired surface contour. The technique is not limited to diamond turning, but can be used to predict warpage from a variety of loading conditions placed on the mirrors

  3. The civic integrationist turn in Danish and Swedish school politics.

    Science.gov (United States)

    Fernández, Christian; Jensen, Kristian Kriegbaum

    2017-01-01

    The civic integrationist turn usually refers to the stricter requirements for residence and citizenship that many states have implemented since the late 1990's. But what of other policy spheres that are essential for the formation of citizens? Is there a civic turn in school policy? And does it follow the pattern of residence and citizenship? This article addresses these questions through a comparative study of the EU's allegedly strictest and most liberal immigration regimes, Denmark and Sweden, respectively. The analysis shows a growing concern with citizenship education in both countries, yet with different styles and content. Citizenship education in Denmark concentrates on reproducing a historically derived core of cultural values and knowledge to which minorities are expected to assimilate, while the Swedish model subscribes to a pluralist view that stresses mutual adaptation and intercultural tolerance. Despite claims to the contrary, the analysis shows that Sweden too has experienced a civic turn.

  4. Second language acquisition in Brazil since the social turn

    Directory of Open Access Journals (Sweden)

    Eduardo Henrique Diniz de Figueiredo

    Full Text Available ABSTRACT The present study is an appraisal of the literature that has been published in second language acquisition (SLA in Brazil since what is widely known as the social turn in the field (BLOCK, 2003. The objective of such an examination is to assess the impact that the social turn has had upon SLA research in the country. One hundred forty-one texts (among articles from top-ranked journals, theses, dissertations, and books were systematically reviewed and categorized based on three main criteria: a main topics, b SLA frameworks/approaches, and c methods used. The results show that socially-guided research seems to have gained space in SLA in Brazil since the social turn; however, cognitivist work in the country is still very strong, and little dialog seems to occur among these different perspectives on SLA.

  5. Browsing Through Closed Books: Evaluation of Preprocessing Methods for Page Extraction of a 3-D CT Book Volume

    Science.gov (United States)

    Stromer, D.; Christlein, V.; Schön, T.; Holub, W.; Maier, A.

    2017-09-01

    It is often the case that a document can not be opened, page-turned or touched anymore due to damages caused by aging processes, moisture or fire. To counter this, special imaging systems can be used. One of our earlier work revealed that a common 3-D X-ray micro-CT scanner is well suited for imaging and reconstructing historical documents written with iron gall ink - an ink consisting of metallic particles. We acquired a volume of a self-made book without opening or page-turning with a single 3-D scan. However, when investigating the reconstructed volume, we faced the problem of a proper automatic extraction of single pages within the volume in an acceptable time without losing information of the writings. Within this work, we evaluate different appropriate pre-processing methods with respect to computation time and accuracy which are decisive for a proper extraction of book pages from the reconstructed X-ray volume and the subsequent ink identification. The different methods were tested for an extreme case with low resolution, noisy input data and wavy pages. Finally, we present results of the page extraction after applying the evaluated methods.

  6. Spatial turn and animation practices inspired by cultural anthropology

    Directory of Open Access Journals (Sweden)

    Agnieszka Wieszaczewska

    2016-09-01

    Full Text Available Spatial turn is one of the cultural turns, which have recently occurred in the humanities. It stresses the importance of issues such as space and place and can be successfully used as a theoretical perspective gaining use in thought over issues such as globalisation, transnationality, mapping but also education. In the discourses of pedagogical science space and place are considered through their multidimensional impact on education and learning. As significant concepts rooting pedagogy or pedagogy of borderland. The pedagogical reflection on space could be also used in the field of animation practices, especially in activities, which are related to place somehow colonised.

  7. A survey report for the turning of biped locomotion robot

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Ichiro; Takanishi, Atsuo [Waseda Univ., Tokyo (Japan); Kume, Etsuo

    1992-12-01

    A mechanical design study of biped locomotion robots is going on at JAERI within the scope of the Human Acts Simulation Program (HASP). The design study at JAERI is of an arbitrarily mobile robot for inspection of nuclear facilities. A survey has been performed for collecting useful information from already existing biped locomotion robots. This is a survey report for the turning of biped locomotion robot: the WL-10R designed and developed at Waseda University. This report includes the control method of turning, machine model and control system. (author).

  8. A new inverter topology using GTO commutation. [Gate Turn Off thyristor

    Science.gov (United States)

    Rippel, W. E.

    1983-01-01

    A new N-phase, forced commutated bridge inverter topology has been developed wherein a single Gate Turn Off Thyristor (GTO) is used to commutate each of 2N main Thyristors (SCRs). Since, for most applications, the primary loss mechanism is the SCR forward drop, very high efficiencies are possible. Compared with conventional pure SCR and pure GTO inverters, cost per kW is lower - in the former case due to the large cost differential between GTOs and SCRs. Other advantages of the new inverter include high power density, low switching losses and stresses, modulation flexibility and amenability to high voltage and high frequency operation.

  9. The extractive imperative in Latin America

    NARCIS (Netherlands)

    Arsel, M.; Hogenboom, B.; Pellegrini, L.

    2016-01-01

    One of the main features of contemporary development politics in Latin America is the prominent role of the state. Another feature is the intensification of natural resource extraction. This extractivist drive is especially pronounced in the countries that are part of the ‘turn to the left’, which

  10. The extractive imperative in Latin America

    NARCIS (Netherlands)

    M. Arsel (Murat); Barbara Hogenboom (B.); L. Pellegrini (Lorenzo)

    2016-01-01

    textabstractOne of the main features of contemporary development politics in Latin America is the prominent role of the state. Another feature is the intensification of natural resource extraction. This extractivist drive is especially pronounced in the countries that are part of the ‘turn to the

  11. Study on a magneto-rheological removal process of periodic turning marks

    Science.gov (United States)

    Jeon, Min-Woo; Jeong, Byeong-Joon; Hyun, Sang-Won; Lee, Kye-Sung; Han, Jeong-Yeol; Kim, Geon-Hee

    2017-10-01

    Single Point Diamond Turning (SPDT) has the potential to cost-effectively manufacture optical materials such as metals and plastic types. However, SPDT generally leaves tool marks on the machined surfaces, which creates problems that can deteriorate the optical performance. Several processes have been studied to eliminate the tool marks caused by SPDT, but it was difficult to carry out without the additional defects like sub-surface damages and other tool marks. To overcome this weakness, we investigated the Magneto-Rheological Finishing (MRF) process to effectively remove the periodic micro structures without surface deterioration for optical performance. The workpiece used in the experiment is a mirror plated with electroless nickel-phosphorus. Through the processing of the SPDT, an initial surface gets periodic tool marks, which have a height of 1.1 μm and a pitch of 20 μm. We studied on the reduction rate of the turning marks by the MRF process with some different conditions of uniform removal. The quantitative analysis of the surface roughness and residual marks was performed using a scanning low-coherence interferometer and through the Power Spectral Density (PSD) respectively. The results showed that reduction rates of tool marks depend on the angles (0, 45, and 90 degs) between the turning direction of the tool marks and the rotation direction of MR wheel. In the case of 45 degs, it indicated the fastest reduction rate.

  12. Synthetic Aperture Computation as the Head is Turned in Binaural Direction Finding

    Directory of Open Access Journals (Sweden)

    Duncan Tamsett

    2017-03-01

    Full Text Available Binaural systems measure instantaneous time/level differences between acoustic signals received at the ears to determine angles λ between the auditory axis and directions to acoustic sources. An angle λ locates a source on a small circle of colatitude (a lamda circle on a sphere symmetric about the auditory axis. As the head is turned while listening to a sound, acoustic energy over successive instantaneous lamda circles is integrated in a virtual/subconscious field of audition. The directions in azimuth and elevation to maxima in integrated acoustic energy, or to points of intersection of lamda circles, are the directions to acoustic sources. This process in a robotic system, or in nature in a neural implementation equivalent to it, delivers its solutions to the aurally informed worldview. The process is analogous to migration applied to seismic profiler data, and to that in synthetic aperture radar/sonar systems. A slanting auditory axis, e.g., possessed by species of owl, leads to the auditory axis sweeping the surface of a cone as the head is turned about a single axis. Thus, the plane in which the auditory axis turns continuously changes, enabling robustly unambiguous directions to acoustic sources to be determined.

  13. Vestibular ablation and a semicircular canal prosthesis affect postural stability during head turns

    Science.gov (United States)

    Thompson, Lara A.; Haburcakova, Csilla; Lewis, Richard F.

    2016-01-01

    In our study, we examined postural stability during head turns for two rhesus monkeys: one, single animal study contrasted normal and mild bilateral vestibular ablation and a second animal study contrasted severe bilateral vestibular ablation with and without prosthetic stimulation. The monkeys freely stood, unrestrained on a balance platform and made voluntary head turns between visual targets. To quantify each animals’ posture, motions of the head and trunk, as well as torque about the body’s center-of-mass, were measured. In the mildly ablated animal, we observed less foretrunk sway in comparison to the normal state. When the canal prosthesis provided electric stimulation to the severely ablated animal, it showed a decrease in trunk sway during head turns. Because the rhesus monkey with severe bilateral vestibular loss exhibited a decrease in trunk sway when receiving vestibular prosthetic stimulation, we propose that the prosthetic electrical stimulation partially restored head velocity information. Our results provide an indication that a semicircular canal prosthesis may be an effective way to improve postural stability in patients with severe peripheral vestibular dysfunction. PMID:27405997

  14. Cryogenic tests of bimetallic diamond-turned mirrors for the FRIDA integral field unit

    Science.gov (United States)

    DeWitt, Curtis; Eikenberry, Stephen; Cuevas Cardona, Salvador; Chapa, Oscar; Espejo, Carlos; Keiman, Carolina; Sanchez, Beatriz

    2008-07-01

    We describe diamond-turned material tests for the integral field unit (IFU) for the FRIDA instrument (inFRared Imager and Dissector for the Adaptive optics system of the Gran Telescopio Canarias). FRIDA is closely based on the design of the successful FISICA cryogenic infrared image slicing device, which used "monolithic" mirror arrays, diamond turned into single pieces of metal. FRIDA, however, will require better roughness characteristics than the 15nm RMS of FISICA to avoid light scatter in FRIDA's shorter wavelength limit (900nm). Al 6061 seems to be limited to this roughness level by its silicate inclusions so some new combination of materials that are compatible with FRIDA's Al 6061 structure must be found. To this end, we have tested six diamond-turned mirrors with different materials and different platings. We used the Zygo interferometer facility at IA-UNAM to do warm and cold profile measurements of the mirrors to investigate possible bimetallic deformation effects. We present a detailed comparison of the various performance characteristics of the test mirrors.

  15. Optimization of surface integrity in dry hard turning using RSM

    Indian Academy of Sciences (India)

    Abstract. This paper investigates the effect of different cutting parameters (cutting speed, feed rate, and depth of cut) on surface integrity defined in terms of surface roughness and microhardness in dry hard turning process. The workpiece material used was hardened alloy steel AISI 52100 and it was machined on a CNC ...

  16. The Effect of Organic Matter Content and Turning Cycle on ...

    African Journals Online (AJOL)

    Composting is an old technology and farmers have applied it in sustainable agriculture. In municipal solid waste management, composting can form part of an integrated system in handling waste for disposal. This study investigated the effect of organic matter content and turning cycle on the composting process of ...

  17. Understanding the Linguistic Turn and the Quest for Meaning ...

    African Journals Online (AJOL)

    Apart from Dilthey the linguistic turn penetrated also the thought of thinkers such as Freud, Wittgenstein, Frankl, Heidegger, Habermas, Dooyeweerd and Gadamer, all of them (implicitly or explicitly) elaborated the initial criticism raised by Herder, Jacobi, Hamann, Heidegger and Gadamer against Kant's Critique of Pure ...

  18. Universals and cultural variation in turn-taking in conversation

    NARCIS (Netherlands)

    Stivers, Tanya; Enfield, N. J.; Brown, Penelope; Englert, Christina; Hayashi, Makoto; Heinemann, Trine; Hoymann, Gertie; Rossano, Federico; de Ruiter, Jan Peter; Yoon, Kyung-Eun; Levinson, Stephen C.

    2009-01-01

    Informal verbal interaction is the core matrix for human social life. A mechanism for coordinating this basic mode of interaction is a system of turn-taking that regulates who is to speak and when. Yet relatively little is known about how this system varies across cultures. The anthropological

  19. A jump persistent turning walker to model zebrafish locomotion.

    Science.gov (United States)

    Mwaffo, Violet; Anderson, Ross P; Butail, Sachit; Porfiri, Maurizio

    2015-01-06

    Zebrafish are gaining momentum as a laboratory animal species for the investigation of several functional and dysfunctional biological processes. Mathematical models of zebrafish behaviour are expected to considerably aid in the design of hypothesis-driven studies by enabling preliminary in silico tests that can be used to infer possible experimental outcomes without the use of zebrafish. This study is motivated by observations of sudden, drastic changes in zebrafish locomotion in the form of large deviations in turn rate. We demonstrate that such deviations can be captured through a stochastic mean reverting jump diffusion model, a process that is commonly used in financial engineering to describe large changes in the price of an asset. The jump process-based model is validated on trajectory data of adult subjects swimming in a shallow circular tank obtained from an overhead camera. Through statistical comparison of the empirical distribution of the turn rate against theoretical predictions, we demonstrate the feasibility of describing zebrafish as a jump persistent turning walker. The critical role of the jump term is assessed through comparison with a simplified mean reversion diffusion model, which does not allow for describing the heavy-tailed distributions observed in the fish turn rate. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

  20. Diamond turning and polishing tests on new RSP aluminium alloys

    NARCIS (Netherlands)

    Horst, R. ter; Haan, M. de; Gubbels, G.P.H.; Senden, R.; Venrooy, B.W.H. van; Hoogstrate, A.M.

    2012-01-01

    For years now conventional aluminium 6061 T6 has widely been used for mirrors in astronomical instruments, being diamond turned or since a few years also being optically polished. This allows the development of optical systems that can be tested and operated at any temperature, without being

  1. Supply and demand of timber for wood turning in Maine

    Science.gov (United States)

    Eric H. Wharton; Robert L., Jr. Nevel; Douglas S. Powell; Douglas S. Powell

    1987-01-01

    An analytical report on the volume of wood used by the wood-turning industry in Maine, and the volume of timber from the state's timberlands that may be suitable for turnstock. Findings are based on the third forest resource survey of Maine timberlands, and an industry canvass of primary manufacturing mills using wood from Maine timberlands, both conducted in 1982...

  2. Performances of cutting fluids in turning. Mineral oil - RM

    DEFF Research Database (Denmark)

    Axinte, Dragos Aurelian; Belluco, Walter

    1999-01-01

    Scope of the present measurement campaign is the evaluation of the cutting fluid performance. The report presents the standard routine and the results obtained when turning stainless steel and brass with a commercial vegetable based oil called RM. The methods were developed to be applicable...

  3. Performances of cutting fluids in turning. Vegetable based oil - RV

    DEFF Research Database (Denmark)

    Axinte, Dragos Aurelian; Belluco, Walter

    1999-01-01

    Scope of the present measurement campaign is the evaluation of the cutting fluid performance. The report presents the standard routine and the results obtained when turning stainless steel and brass with a commercial vegetable based oil called RV. The methods were developed to be applicable...

  4. Online Memorials 2.0: When Mourning Turns Social

    DEFF Research Database (Denmark)

    Gotved, Stine

    This paper investigates the turn from individual to social online mourning rituals and introduces a research project that follows a new memorial platform where the best from both sides are sought combined. The Danish online memorial site from 2000, mindet.dk, is about to launch in a version 2...

  5. A Rhetoric of Turns: Signs and Symbols in Education

    Science.gov (United States)

    Rutten, Kris; Soetaert, Ronald

    2014-01-01

    In our research and teaching we explore the value and the place of rhetoric in education. From a theoretical perspective we situate our work in different disciplines, inspired by major "turns": linguistic, cultural, anthropological/ethnographic, interpretive, semiotic, narrative, literary, rhetorical etc. In this article we engage in the…

  6. Optimization of turning process parameters by using grey-Taguchi ...

    African Journals Online (AJOL)

    The main objective of this study is to improve toughness and hardness of engineering material by changing the machining parameters of turning process. By applying Taguchi method the quality of manufactured goods, and engineering designs are developed by studying variations. In this work, an attempt has been made to ...

  7. Turning shopping habits of young consumers into green

    NARCIS (Netherlands)

    Bialkova, Svetlana; van 't Erve, Sanne; van Hoof, Joris Jasper; Pruyn, Adriaan T.H.; Bigné, Enrique

    2014-01-01

    Consumers have strong shopping habits, and although being aware of sustainable issues, they hardly do green shopping. Therefore, a challenging question is: how to break the old shopping habits and turn those into green? The current study addresses this question looking at barriers and potential

  8. The turning of the wind in the atmospheric boundary layer

    DEFF Research Database (Denmark)

    Pena Diaz, Alfredo; Gryning, Sven-Erik; Floors, Rogier Ralph

    2014-01-01

    at the Høvsøre site in Denmark, which is a flat farmland area with a nearly homogeneous easterly upstream sector. Therefore, within that sector, the turning of the wind is caused by a combination of atmospheric stability, Coriolis, roughness, horizontal pressure gradient and baroclinity effects. Atmospheric...

  9. On Kinesic Triadic Relations in Turn-Taking

    Science.gov (United States)

    Pike, Kenneth L.

    1975-01-01

    This article discusses three characteristics useful in defining the relations between speakers in the turn-taking aspects of conversation: the derivational history of personal relationships, stop-action pseudo-history versus dynamic compacted posing, and the criss-crossing of verbal versus kinetic axes. (Available from Semiotica, Co-Libri, P.O.…

  10. Turn me on 100 easy ways to use solar energy

    CERN Document Server

    Kodis, Michelle

    2009-01-01

    HERE COMES THE SUN! With page after page of creative and innovative ideas for using this limitless form of energy, as well as thoughtfully compiled lists of useful resources, Turn Me On is an introductory guide to understanding the exciting advances in a progressing technology that harnesses the boundless power of the sun to bring us clean, renewable energy.

  11. Stuart Cloete's construction of voortrekker religion in Turning Wheels ...

    African Journals Online (AJOL)

    Stuart Cloete's novel of 1937, Turning Wheels, was unquestionably the most controversial of many fictional reconstructions of the Great Trek, a book which fell foul of Afrikaner nationalism and whose further importation into the Union of South Africa was long consequently banned. Religious motifs reflecting the popularised ...

  12. Turning of materials with high-speed abrasive waterjet

    Czech Academy of Sciences Publication Activity Database

    Sitek, Libor; Hlaváček, Petr

    -, October 2016 (2016), s. 1160-1165 ISSN 1805-0476 R&D Projects: GA MŠk ED2.1.00/03.0082; GA MŠk(CZ) LO1406 Institutional support: RVO:68145535 Keywords : abrasive water jet machining * turning * steel * rock * wood Subject RIV: JQ - Machines ; Tools http://www.mmscience.eu/content/file/archives/MM_Science_201692.pdf

  13. Optimization of surface integrity in dry hard turning using RSM

    Indian Academy of Sciences (India)

    This paper investigates the effect of different cutting parameters (cutting speed, feed rate, and depth of cut) on surface integrity defined in terms of surface roughness and microhardness in dry hard turning process. The workpiece material used was hardened alloy steel AISI 52100 and it was machined on a CNC lathe with ...

  14. Spanish and American Turn-Taking Styles: A Comparative Study.

    Science.gov (United States)

    Berry, Anne

    A comparative study of turn-taking in North American and Spanish conversation investigated (1) differences in styles for the two cultures and (2) any resulting misinterpretation of communicative intentions. Data for the first were drawn from two dinner parties, one with four American women, conducted in English, and one with four Spanish-speaking…

  15. Optimization of surface integrity in dry hard turning using RSM

    Indian Academy of Sciences (India)

    power transmission components. Bearing steels (e.g., AISI 52100) are the most common exam- ples of these materials, which are conventionally finished by grinding (Diniz et al 2003; Ramesh et al 2005; Umbrello et al 2008; Paiva et al 2009; Thiele & Melkote 1999). Hard turning is generally used as a substitute to grinding ...

  16. CNC Turning Technician. A Competency-Based Instructional System.

    Science.gov (United States)

    Sloan, Kelly; Hilley, Robert

    This competency-based curriculum guide for instructing students in using computer numerically controlled (CNC) turning machines is one of a series of instructional guides for the machinist field developed in Oklahoma. Although developed jointly with Baxter Technologies Corporation and oriented toward the Baxter Vo-Tec 2000 Future Builder CNC…

  17. Cutting power prediction model for turning of GFRP composites ...

    African Journals Online (AJOL)

    user

    Glass fiber reinforced plastic (GFRP) composite materials are replacing traditional engineering materials owing to their superior properties ... highly corrosive industrial applications. They are ... (2000) turning operation is one of the most important operation used for machine elements construction in manufacturing industries ...

  18. Characterization of jellyfish turning using 3D-PTV

    Science.gov (United States)

    Xu, Nicole; Dabiri, John

    2017-11-01

    Aurelia aurita are oblate, radially symmetric jellyfish that consist of a gelatinous bell and subumbrellar muscle ring, which contracts to provide motive force. Swimming is typically modeled as a purely vertical motion; however, asymmetric activations of swim pacemakers (sensory organs that innervate the muscle at eight locations around the bell margin) result in turning and more complicated swim behaviors. More recent studies have examined flow fields around turning jellyfish, but the input/output relationship between locomotive controls and swim trajectories is unclear. To address this, bell kinematics for both straight swimming and turning are obtained using 3D particle tracking velocimetry (3D-PTV) by injecting biocompatible elastomer tags into the bell, illuminating the tank with ultraviolet light, and tracking the resulting fluorescent particles in a multi-camera setup. By understanding these kinematics in both natural and externally controlled free-swimming animals, we can connect neuromuscular control mechanisms to existing flow measurements of jellyfish turning for applications in designing more energy efficient biohybrid robots and underwater vehicles. NSF GRFP.

  19. Postcolonial turn : re-imagining anthropology and Africa

    NARCIS (Netherlands)

    Devisch, R.; Nyamnjoh, F.

    2011-01-01

    This book is a reflection on the mental decolonization of the postcolonialist turn in Africanist scholarship and is simultaneously a tribute to the late Professor Archibald Mafeje. A number of the articles, including the Introduction by A. Olukoshi and F. Nyamnjoh, are reprinted from the Codesria

  20. The 'Turn to Parenting': Paradigm shift or work in progress?

    NARCIS (Netherlands)

    Hopman, M.; Knijn, G.C.M.

    In the field of child and youth support, preventive and parent-oriented support programs are currently emphasized. This is understood as a new paradigm of parenting support, which is sometimes referred to as “the turn to parenting.” Using Campbell’s (Annual Review of Sociology, 28:21–38, 2002),

  1. Diplomas Count 2013: Second Chances--Turning Dropouts into Graduates

    Science.gov (United States)

    Education Week, 2013

    2013-01-01

    The 2013 edition of "Diplomas Count," entitled "Second Chances: Turning Dropouts into Graduates," examines dropout recovery and innovative strategies for returning to the educational fold the 1 million students who leave school without a diploma each year. "Education Week's" journalists investigate interventions that…

  2. Student Wellbeing and the Therapeutic Turn in Education

    Science.gov (United States)

    Wright, Katie

    2014-01-01

    This article considers current concerns with promoting student mental health and wellbeing against the backdrop of critiques of the "therapeutic turn" in education. It begins by situating accounts of "therapeutic education" within broader theorisation of therapeutic culture. In doing so, the importance of this work is…

  3. The Digital Turn. How the internet transforms our existence

    NARCIS (Netherlands)

    Westera, Wim

    2014-01-01

    The presentation is based on my book The Dital Turn. The swift virtualisation of the world implies a radical change of the conditions of life. We have to cope with the fact that our experiences of the world will largely be mediated experiences, fuelled by data, cameras, sensors, indicators and

  4. Getting 'Entangled': Reflexivity and the 'Critical Turn' in Tourism Studies

    NARCIS (Netherlands)

    Ateljevic, I.; Harris, C.; Wilson, E.; Collins, F.L.

    2005-01-01

    Reflecting a broader postmodern shift to unmask the cultural politics of research and knowledge-making in academia, tourism studies as a field is demonstrating a notable `critical turn¿ ¿ a shift in thought that serves to provide and legitimise a space for more interpretative and critical modes of

  5. Turning Sunlight into Electricity-Inorganic Solar Cells and Beyond

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 16; Issue 12. Turning Sunlight into Electricity - Inorganic Solar Cells and Beyond. A K Shukla. Volume 16 Issue 12 December 2011 pp 1294-1302. Fulltext. Click here to view fulltext PDF. Permanent link:

  6. Ten-metre walk, with or without a turn?

    NARCIS (Netherlands)

    van Herk, IEH; Arendzen, J. Hans; Rispens, P

    Objective: To compare results obtained using different procedures to measure 10-metre walking time. Design: Walking was limed over a straight 10 m, and over 5 m with return, Further, the time taken to turn was measured directly. Setting: Rehabilitation department of a university hospital. Subjects:

  7. Using Facebook Data to Turn Introductory Statistics Students into Consultants

    Science.gov (United States)

    Childers, Adam F.

    2017-01-01

    Facebook provides businesses and organizations with copious data that describe how users are interacting with their page. This data affords an excellent opportunity to turn introductory statistics students into consultants to analyze the Facebook data using descriptive and inferential statistics. This paper details a semester-long project that…

  8. Intelligent Tool Condition Monitoring In High-Speed Turning Of ...

    African Journals Online (AJOL)

    In this paper, a Multi-Layered Perceptron (MLP) neural net-work model has been developed for on-line condition monitoring of tool wear in high-speed turning of Titanium-based alloy (Ti-6Al-4V). Machining trials were ... The neural network model was designed using Matlab® neural toolbox. Accuracy of model for the ...

  9. Investing in Training and Development. Turning Interest into Capital.

    Science.gov (United States)

    Pont, Tony

    This book, which is intended for individuals responsible for human resource development (HRD) programs, examines a number of issues in turning investments in training and development into human capital and examines ways of making the workplace an arena for development. The following topics are discussed: the nature and role of training and…

  10. Causal Role of Motor Simulation in Turn-Taking Behavior.

    Science.gov (United States)

    Hadley, Lauren V; Novembre, Giacomo; Keller, Peter E; Pickering, Martin J

    2015-12-16

    Overlap between sensory and motor representations has been documented for a range of human actions, from grasping (Rizzolatti et al., 1996b) to playing a musical instrument (Novembre and Keller, 2014). Such overlap suggests that individuals use motor simulation to predict the outcome of observed actions (Wolpert, 1997). Here we investigate motor simulation as a basis of human communication. Using a musical turn-taking task, we show that pianists call on motor representations of their partner's part to predict when to come in for their own turn. Pianists played alternating solos with a videoed partner, and double-pulse transcranial magnetic stimulation was applied around the turn-switch to temporarily disrupt processing in two cortical regions implicated previously in different forms of motor simulation: (1) the dorsal premotor cortex (dPMC), associated with automatic motor resonance during passive observation of hand actions, especially when the actions are familiar (Lahav et al., 2007); and (2) the supplementary motor area (SMA), involved in active motor imagery, especially when the actions are familiar (Baumann et al., 2007). Stimulation of the right dPMC decreased the temporal accuracy of pianists' (right-hand) entries relative to sham when the partner's (left-hand) part had been rehearsed previously. This effect did not occur for dPMC stimulation without rehearsal or for SMA stimulation. These findings support the role of the dPMC in predicting the time course of observed actions via resonance-based motor simulation during turn-taking. Because turn-taking spans multiple modes of human interaction, we suggest that simulation is a foundational mechanism underlying the temporal dynamics of joint action. Even during passive observation, seeing or hearing somebody execute an action from within our repertoire activates motor cortices of our brain. But what is the functional relevance of such "motor simulation"? By combining a musical duet task with a real

  11. EXPANDING EXTRACTIONS

    NARCIS (Netherlands)

    Dietzenbacher, Erik; Lahr, Michael L.

    2013-01-01

    In this paper, we generalize hypothetical extraction techniques. We suggest that the effect of certain economic phenomena can be measured by removing them from an input-output (I-O) table and by rebalancing the set of I-O accounts. The difference between the two sets of accounts yields the

  12. Transient Behaviour of Interacting Extractive System

    International Nuclear Information System (INIS)

    El-Bialy, S.H.; Elsherbiny, A.E.

    2000-01-01

    The aim of this study is to investigate the dynamic behaviour of mixer-settler extractive system, which represents an interacting one. When a stimulus single is introduced to aqueous feed; the response of the aqueous phase of the first stage is considered as stimulus signals to both organic phase in the same stage and the aqueous phase of the second one. The response of the last phase represents-in turn- stimulus signals to both organic phase in the same stage and the aqueous phase in the next one. Mathematical model was derived for a system consisting of two stages in the cascade. The model assumed a continuous stirred tank reactor (CSTR) for mixer zone and variable holdups and flow rates of both aqueous and organic phases during operation. Non-linear equilibrium was considered. The obtained model-being non-linear- was linearized and Laplace transformation method was used to solve the model. The system constants are those corresponding to extraction of uranyl nitrate from 3 N nitric acid solution using Tbp dissolved in kerosene at 30% of the former. Stimulus-response test was carried out on the model by considering a step increase in solute concentration in aqueous feed stream. The system behaviour was tested at different values of operating parameters. First order behaviour for the first stage was observed and higher order for the rest of the system. A general relation for the difference in the power of the denominator and numerator of the transfer function of the i th stage was concluded for aqueous phase. The study showed that the system overdamp over the practical range of chosen parameters as explained from the values of transfer function roots

  13. Turn-off” fluorescent data array sensor based on double quantum dots coupled with chemometrics for highly sensitive and selective detection of multicomponent pesticides

    Energy Technology Data Exchange (ETDEWEB)

    Fan, Yao; Liu, Li; Sun, Donglei; Lan, Hanyue [The Modernization Engineering Technology Research Center of Ethnic Minority Medicine of Hubei Province, College of Pharmacy, South-Central University for Nationalities, Wuhan 430074 (China); Fu, Haiyan, E-mail: fuhaiyan@mail.scuec.edu.cn [The Modernization Engineering Technology Research Center of Ethnic Minority Medicine of Hubei Province, College of Pharmacy, South-Central University for Nationalities, Wuhan 430074 (China); Yang, Tianming, E-mail: tmyang@mail.scuec.edu.cn [The Modernization Engineering Technology Research Center of Ethnic Minority Medicine of Hubei Province, College of Pharmacy, South-Central University for Nationalities, Wuhan 430074 (China); She, Yuanbin, E-mail: sheyb@zjut.edu.cn [State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310032 (China); Ni, Chuang [The Modernization Engineering Technology Research Center of Ethnic Minority Medicine of Hubei Province, College of Pharmacy, South-Central University for Nationalities, Wuhan 430074 (China)

    2016-04-15

    As a popular detection model, the fluorescence “turn-off” sensor based on quantum dots (QDs) has already been successfully employed in the detections of many materials, especially in the researches on the interactions between pesticides. However, the previous studies are mainly focused on simple single track or the comparison based on similar concentration of drugs. In this work, a new detection method based on the fluorescence “turn-off” model with water-soluble ZnCdSe and CdSe QDs simultaneously as the fluorescent probes is established to detect various pesticides. The fluorescence of the two QDs can be quenched by different pesticides with varying degrees, which leads to the differences in positions and intensities of two peaks. By combining with chemometrics methods, all the pesticides can be qualitative and quantitative respectively even in real samples with the limit of detection was 2 × 10{sup −8} mol L{sup −1} and a recognition rate of 100%. This work is, to the best of our knowledge, the first report on the detection of pesticides based on the fluorescence quenching phenomenon of double quantum dots combined with chemometrics methods. What's more, the excellent selectivity of the system has been verified in different mediums such as mixed ion disruption, waste water, tea and water extraction liquid drugs. - Highlights: • A new model based on double QDs is established for pesticide residues detection. • The fluorescent data array sensor is coupled with chmometrics methods. • The sensor can be highly sensitive and selective detection in actual samples.

  14. Power losses in the international linear collider 20 mrad extraction ...

    Indian Academy of Sciences (India)

    to the emission of hard beamstrahlung photons, which can then turn into coherent pairs. A careful design of the extraction line must be performed in order to transport the outgoing charged beams and beamstrahlung photons from the interaction point to their dump. In this study, we estimate the beam losses in the extraction ...

  15. Turn around management of open-cast lignite mines in Kosovo; Turn Around Management der Braunkohletagebaue im Kosovo

    Energy Technology Data Exchange (ETDEWEB)

    Hoehna, U. [Vattenfall Europe Mining AG, Cottbus (Germany). Vattenfall Mining Consulting

    2008-03-15

    In their cooperation in turn around management of KEK, Vattenfall Europe Mining Consulting made an important contribution to supporting the Kosovo. In spite of limited resources and a short time available, many practical steps were taken, and effective, sustainable and safe operation of the open-cast mine was achieved. (orig.)

  16. Morphing of Building Footprints Using a Turning Angle Function

    Directory of Open Access Journals (Sweden)

    Jingzhong Li

    2017-06-01

    Full Text Available We study the problem of morphing two polygons of building footprints at two different scales. This problem frequently occurs during the continuous zooming of interactive maps. The ground plan of a building footprint on a map has orthogonal characteristics, but traditional morphing methods cannot preserve these geographic characteristics at intermediate scales. We attempt to address this issue by presenting a turning angle function-based morphing model (TAFBM that can generate polygons at an intermediate scale with an identical turning angle for each side. Thus, the orthogonal characteristics can be preserved during the entire interpolation. A case study demonstrates that the model yields good results when applied to data from a building map at various scales. During the continuous generalization, the orthogonal characteristics and their relationships with the spatial direction and topology are well preserved.

  17. Turn-key SRF accelerators to drive subcritical reactors

    International Nuclear Information System (INIS)

    Johnson, Rolland P.

    2011-01-01

    Large particle accelerator projects, both accomplished and proposed, have been used to engage US industry through contracts and grants to develop efficient capabilities to design, develop, produce, and deliver entire accelerator systems or any needed subsystems. Staffed in many cases by experienced scientists and engineers from National Laboratories and Universities, existing companies could extend their portfolios to offer turn-key accelerators with parameters to match the needs of ADS. If the reactors were based on molten salt fuel such that trip rate requirements were relaxed, the developments needed for a multi-MW proton accelerator for ADS would be minimal. Turn-key SRF proton linacs for ADS operation can be ordered now to enable GW-level power generation from natural thorium, natural uranium, or nuclear waste from conventional reactors. (author)

  18. Welcome to the revolution: The sensory turn and art history

    Directory of Open Access Journals (Sweden)

    Jenni Lauwrens

    2012-12-01

    Full Text Available Discourses concerned with the sensorially embodied subject have emerged since the 1990s in various disciplines including history, anthropology, sociology, geography, film studies and literary studies. The purpose of this article is to bring the conversation regarding audiences’ embodied engagement in culture closer to art history by investigating the implications of what has been termed the sensory turn for this discipline. One of the accusations lodged against art history by supporters of the multi-sensoriality of embodied human experience is its alleged ocularcentrism, the implication of which is a detached autonomous subject. In this article, the sensory turn is defined and contextualized, particularly in light of the body of criticism targeted at art history’s emphasis on the visual. The proposed ways in which art historians might usefully deal with audience’s embodied experiences of not only immersive installation works of art, but also artworks in traditional media, such as painting and photography, are teased apart.

  19. Turned trochoidal disturbance on a liquid jet surface

    Science.gov (United States)

    Sadik, Shalom; Kirzhner, Felix; Kramarenko, Denis

    2014-07-01

    This paper shows that a turned trochoidal function disturbance may lead to peripheral drops production. The resulting model is used to describe that a turned trochoidal disturbance leads to peripheral drops production on the liquid jet surface without the necessity for superimposed disturbances. The trochoid is a non-unique parametric function. Only non-unique parametric functions disturbances may lead to peripheral drops production. The trochoidal function disturbance is decomposed to Fourier series. Every Fourier element receives an amplification factor in accordance to the Rayleigh inviscid jet model. Peripheral drops are received on the jet surface. The paper shows that all trochoidal disturbance functions, prolate cycloid, cycloid and curtate cycloid have a capability of peripheral drops producing. A limited capability of peripheral drops production is introduced for the trochoidal curtate cycloid. Produced drops size are reduced for increasing the jet velocity and wave number. Smaller drops are also received by transition from the prolate cycloid to curtate cycloid disturbance.

  20. Left-handed helical preference in an achiral peptide chain is induced by an L-amino acid in an N-terminal type II β-turn.

    Science.gov (United States)

    De Poli, Matteo; De Zotti, Marta; Raftery, James; Aguilar, Juan A; Morris, Gareth A; Clayden, Jonathan

    2013-03-15

    Oligomers of the achiral amino acid Aib adopt helical conformations in which the screw-sense may be controlled by a single N-terminal residue. Using crystallographic and NMR techniques, we show that the left- or right-handed sense of helical induction arises from the nature of the β-turn at the N terminus: the tertiary amino acid L-Val induces a left-handed type II β-turn in both the solid state and in solution, while the corresponding quaternary amino acid L-α-methylvaline induces a right-handed type III β-turn.

  1. Turning the tide : tidal power in the UK

    OpenAIRE

    Sustainable Development Commission

    2007-01-01

    Contents: Turning the tide : tidal power in the UK -- Executive summary -- Tidal power in the UK : research report 1 : UK tidal resource assessment -- Tidal power in the UK : research report 2 : tidal technologies overview -- Tidal power in the UK : research report 3 : Severn barrage proposals -- Tidal power in the UK : research report 4 : Severn non-barrage options -- Tidal power in the UK : research report 5 : UK case studies. Summarised in the Welsh language version of the executive ...

  2. Performances of cutting fluids in turning. Formulated oil - E

    DEFF Research Database (Denmark)

    Axinte, Dragos A.; Steffanato, Simone

    Tool life is a parameter closely connected to the lubricating effect of a cutting fluid. Long tool life in turning corresponds to good lubrication and a process with good lubrication is preferred, since it normally results in lower tool wear and better surface quality. Cutting forces are mainly...... important for understanding the mechanism of the cutting process itself and to perform in this way data about the influence of the cutting fluids....

  3. Turning an Urban Scene Video into a Cinemagraph

    OpenAIRE

    Yan, Hang; Liu, Yebin; Furukawa, Yasutaka

    2016-01-01

    This paper proposes an algorithm that turns a regular video capturing urban scenes into a high-quality endless animation, known as a Cinemagraph. The creation of a Cinemagraph usually requires a static camera in a carefully configured scene. The task becomes challenging for a regular video with a moving camera and objects. Our approach first warps an input video into the viewpoint of a reference camera. Based on the warped video, we propose effective temporal analysis algorithms to detect reg...

  4. Analysis of the influence of tool dynamics in diamond turning

    Energy Technology Data Exchange (ETDEWEB)

    Fawcett, S.C.; Luttrell, D.E.; Keltie, R.F.

    1988-12-01

    This report describes the progress in defining the role of machine and interface dynamics on the surface finish in diamond turning. It contains a review of literature from conventional and diamond machining processes relating tool dynamics, material interactions and tool wear to surface finish. Data from experimental measurements of tool/work piece interface dynamics are presented as well as machine dynamics for the DTM at the Center.

  5. The performative turn at Inhotim: installation art and Baudelairean modernity

    OpenAIRE

    Lauren S. Weingarden

    2013-01-01

    This article explores the participatory turn in installation art as part of a trajectory from Baudelairean modernity to twentyfirst-century postmodernity, as represented at Inhotim, the outdoor contemporary art museum and botanical gardens in Brumadinho, MG. In his 1862 essay “The Painter of ModernLife,” Charles Baudelaire defined modernity as fleeting, transitory and fragmentary. Baudelairean modernity initiated a breakdown of boundaries between art and life and between high art aesthetics a...

  6. Fuzzy Linguistic Optimization on Surface Roughness for CNC Turning

    OpenAIRE

    Lan, Tian-Syung

    2010-01-01

    Surface roughness is often considered the main purpose in contemporary computer numerical controlled (CNC) machining industry. Most existing optimization researches for CNC finish turning were either accomplished within certain manufacturing circumstances or achieved through numerous equipment operations. Therefore, a general deduction optimization scheme is deemed to be necessary for the industry. In this paper, the cutting depth, feed rate, speed, and tool nose runoff with low, medium, and...

  7. Ribosomal RNA Kink-turn motif - A flexible molecular hinge

    Czech Academy of Sciences Publication Activity Database

    Rázga, F.; Špačková, Naďa; Réblová, K.; Koča, J.; Leontis, N. B.; Šponer, Jiří

    2004-01-01

    Roč. 22, č. 2 (2004), s. 183-193 ISSN 0739-1102 R&D Projects: GA MŠk LN00A016 Grant - others:Wellcome Trust(GB) GR067507MF; National Institutes of Health(US) 2R15 GM55898 Institutional research plan: CEZ:AV0Z5004920 Keywords : ribosomal RNA * K-turn * molecular dynamics Subject RIV: BO - Biophysics Impact factor: 1.113, year: 2004

  8. Ribosomal RNA Kink-turn motif - a flexible molecular hinge

    Czech Academy of Sciences Publication Activity Database

    Rázga, Filip; Špačková, Naďa; Réblová, K.; Koča, J.; Leontis, Neocles B.; Šponer, Jiří

    2005-01-01

    Roč. 12, č. 1 (2005), s. 38-38 ISSN 1211-5894. [Setkání českých a slovenských strukturních biologů 2005. Nové Hrady, 15.09.2005-20.09.2005] Institutional research plan: CEZ:AV0Z50040507 Keywords : Kink-turn motif Subject RIV: BO - Biophysics

  9. Mycoleptodiscus terrestris: An Endophyte Turned Latent Pathogen of Eurasian Watermilfoil

    Science.gov (United States)

    2009-03-01

    Clavicipitaceous fungal endophytes of grasses: Coevolution and the change from parasitism to mutualism. In Co-evolution of fungi with plants and animals, ed...Recovery of endophytic fungi from Myriophyllum spicatum. APCRP Technical Notes Collection. ERDC TN-APCRP-BC-03. Vicksburg, MS: U.S. Army Engineer...ERDC/TN APCRP-BC-11 March 2009 1 Mycoleptodiscus terrestris: An Endophyte Turned Latent Pathogen of Eurasian Watermilfoil by Judy F

  10. Machining parameter optimization in turning process for sustainable manufacturing

    OpenAIRE

    S. G. Dambhare; S. J. Deshmukh; A. B. Borade

    2015-01-01

    There is an increase in awareness about sustainable manufacturing process. Manufacturing industries are backbone of a country’s economy. Although it is important but there is a great concern about consumption of resources and waste creation. The primary aim of this study was to explore sustainability concern in turning process in an Indian machining industry. The effect of cutting parameters, Speed/Feed/Depth of Cut, the machining environment, Dry/MQL/Wet, and the type of cutting tool on sust...

  11. Enhanced ultrasonically assisted turning of a β-titanium alloy.

    Science.gov (United States)

    Maurotto, Agostino; Muhammad, Riaz; Roy, Anish; Silberschmidt, Vadim V

    2013-09-01

    Although titanium alloys have outstanding mechanical properties such as high hot hardness, a good strength-to-weight ratio and high corrosion resistance; their low thermal conductivity, high chemical affinity to tool materials severely impair their machinability. Ultrasonically assisted machining (UAM) is an advanced machining technique, which has been shown to improve machinability of a β-titanium alloy, namely, Ti-15-3-3-3, when compared to conventional turning processes. Copyright © 2013 Elsevier B.V. All rights reserved.

  12. Computational modeling of turn-taking dynamics in spoken conversations

    OpenAIRE

    Chowdhury, Shammur Absar

    2017-01-01

    The study of human interaction dynamics has been at the center for multiple research disciplines in- cluding computer and social sciences, conversational analysis and psychology, for over decades. Recent interest has been shown with the aim of designing computational models to improve human-machine interaction system as well as support humans in their decision-making process. Turn-taking is one of the key aspects of conversational dynamics in dyadic conversations and is an integral part of hu...

  13. Turning palm leaves into wood: Opportunities for Egypt's rural ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    friendly techniques for solar drying and gluing together midribs to form wooden blocks. El-Mously's team developed a ground-breaking extraction technique that, unlike the traditional cutting, is free of noise and pollution, reduces energy ...

  14. Capturing the Cranio-Caudal Signature of a Turn with Inertial Measurement Systems: Methods, Parameters Robustness and Reliability

    Directory of Open Access Journals (Sweden)

    Karina Lebel

    2017-08-01

    Full Text Available BackgroundTurning is a challenging mobility task requiring coordination and postural stability. Optimal turning involves a cranio-caudal sequence (i.e., the head initiates the motion, followed by the trunk and the pelvis, which has been shown to be altered in patients with neurodegenerative diseases, such as Parkinson’s disease as well as in fallers and frails. Previous studies have suggested that the cranio-caudal sequence exhibits a specific signature corresponding to the adopted turn strategy. Currently, the assessment of cranio-caudal sequence is limited to biomechanical labs which use camera-based systems; however, there is a growing trend to assess human kinematics with wearable sensors, such as attitude and heading reference systems (AHRS, which enable recording of raw inertial signals (acceleration and angular velocity from which the orientation of the platform is estimated. In order to enhance the comprehension of complex processes, such as turning, signal modeling can be performed.AimThe current study investigates the use of a kinematic-based model, the sigma-lognormal model, to characterize the turn cranio-caudal signature as assessed with AHRS.MethodsSixteen asymptomatic adults (mean age = 69.1 ± 7.5 years old performed repeated 10-m Timed-Up-and-Go (TUG with 180° turns, at varying speed. Head and trunk kinematics were assessed with AHRS positioned on each segments. Relative orientation of the head to the trunk was then computed for each trial and relative angular velocity profile was derived for the turn phase. Peak relative angle (variable and relative velocity profiles modeled using a sigma-lognormal approach (variables: Neuromuscular command amplitudes and timing parameters were used to extract and characterize the cranio-caudal signature of each individual during the turn phase.ResultsThe methodology has shown good ability to reconstruct the cranio-caudal signature (signal-to-noise median of 17.7. All variables

  15. Capturing the Cranio-Caudal Signature of a Turn with Inertial Measurement Systems: Methods, Parameters Robustness and Reliability.

    Science.gov (United States)

    Lebel, Karina; Nguyen, Hung; Duval, Christian; Plamondon, Réjean; Boissy, Patrick

    2017-01-01

    Turning is a challenging mobility task requiring coordination and postural stability. Optimal turning involves a cranio-caudal sequence (i.e., the head initiates the motion, followed by the trunk and the pelvis), which has been shown to be altered in patients with neurodegenerative diseases, such as Parkinson's disease as well as in fallers and frails. Previous studies have suggested that the cranio-caudal sequence exhibits a specific signature corresponding to the adopted turn strategy. Currently, the assessment of cranio-caudal sequence is limited to biomechanical labs which use camera-based systems; however, there is a growing trend to assess human kinematics with wearable sensors, such as attitude and heading reference systems (AHRS), which enable recording of raw inertial signals (acceleration and angular velocity) from which the orientation of the platform is estimated. In order to enhance the comprehension of complex processes, such as turning, signal modeling can be performed. The current study investigates the use of a kinematic-based model, the sigma-lognormal model, to characterize the turn cranio-caudal signature as assessed with AHRS. Sixteen asymptomatic adults (mean age = 69.1 ± 7.5 years old) performed repeated 10-m Timed-Up-and-Go (TUG) with 180° turns, at varying speed. Head and trunk kinematics were assessed with AHRS positioned on each segments. Relative orientation of the head to the trunk was then computed for each trial and relative angular velocity profile was derived for the turn phase. Peak relative angle (variable) and relative velocity profiles modeled using a sigma-lognormal approach (variables: Neuromuscular command amplitudes and timing parameters) were used to extract and characterize the cranio-caudal signature of each individual during the turn phase. The methodology has shown good ability to reconstruct the cranio-caudal signature (signal-to-noise median of 17.7). All variables were robust to speed variations ( p

  16. Fuzzy Linguistic Optimization on Surface Roughness for CNC Turning

    Directory of Open Access Journals (Sweden)

    Tian-Syung Lan

    2010-01-01

    Full Text Available Surface roughness is often considered the main purpose in contemporary computer numerical controlled (CNC machining industry. Most existing optimization researches for CNC finish turning were either accomplished within certain manufacturing circumstances or achieved through numerous equipment operations. Therefore, a general deduction optimization scheme is deemed to be necessary for the industry. In this paper, the cutting depth, feed rate, speed, and tool nose runoff with low, medium, and high level are considered to optimize the surface roughness for finish turning based on L9(34 orthogonal array. Additionally, nine fuzzy control rules using triangle membership function with respective to five linguistic grades for surface roughness are constructed. Considering four input and twenty output intervals, the defuzzification using center of gravity is then completed. Thus, the optimum general fuzzy linguistic parameters can then be received. The confirmation experiment result showed that the surface roughness from the fuzzy linguistic optimization parameters is significantly advanced compared to that from the benchmark. This paper certainly proposes a general optimization scheme using orthogonal array fuzzy linguistic approach to the surface roughness for CNC turning with profound insight.

  17. A Rationally Designed Reversible 'Turn-Off' Sensor for Glutathione.

    Science.gov (United States)

    Heng, Sabrina; Zhang, Xiaozhou; Pei, Jinxin; Abell, Andrew D

    2017-09-06

    γ-Glutamyl-cysteinyl-glycine (GSH) plays a critical role in maintaining redox homeostasis in biological systems and a decrease in its cellular levels is associated with diseases. Existing fluorescence-based chemosensors for GSH acts as irreversible reaction-based probes that exhibit a maximum fluorescence ('turn-on') once the reaction is complete, regardless of the actual concentration of GSH. A reversible, reaction-based 'turn-off' probe ( 1 ) is reported here to sense the decreasing levels of GSH, a situation known to occur at the onset of various diseases. The more fluorescent merocyanine (MC) isomer of 1 exists in aqueous solution and this reacts with GSH to induce formation of the ring-closed spiropyran (SP) isomer, with a measurable decrease in absorbance and fluorescence ('turn-off'). Sensor 1 has good aqueous solubility and shows an excellent selectivity for GSH over other biologically relevant metal ions and aminothiol analytes. The sensor permeates HEK 293 cells and an increase in fluorescence is observed on adding buthionine sulfoximine, an inhibitor of GSH synthesis.

  18. Leibniz, Lefebvre and the spatial turn in law

    Directory of Open Access Journals (Sweden)

    Isolde de Villiers

    2016-11-01

    Full Text Available This contribution takes as its point of departure the spatial turn in law and the notion of spatial justice. It traces the term ‘spatial justice’ as introduced through the Spatial Planning and Land Use Management Act and it looks at the underlying view of space that has influenced the spatial turn in law. It furthermore investigates the ways in which the spatial turn in law has been influenced by the thinking of Henri Lefebvre, who relies on a Leibnizian conception of space. Lastly the link between Leibniz and legal positivism is considered in order to reach the final conclusion in the form of a caution against merely adding the language of spatial justice to an approach to space that remains caught up in abstract space. This will only further entrench existing fault lines in society. For this conclusion the work of Roger Berkowitz is central. Berkowitz argues convincingly that the work of Leibniz was central in the development of legal positivism, despite Leibniz in general being considered as a natural law thinker. The same applies to spatial justice theory, where the work of Leibniz is central: it may present the possibilities of another law – the law as it ought to be. The law conceptualised as ‘ought’ instead of ‘is’ would promote reconciliation. Alternatively, spatial justice can simply present the law as it ‘is’ and reconfirm and deepen the chasms in our world.

  19. [From waste to treasure: turning activated sludge into bioplastic poly-3-hydroxybutyrate].

    Science.gov (United States)

    Chen, Jia'ni

    2017-12-25

    Large quantity of activated sludge is generated from wastewater treatment but without yet an appropriate deposition. High temperature can lyse the activate sludge so that nitrogen and phosphorus containing nutrients are released. Halomonas CJN was found to grow on the heat lysed activated sludge and glucose for production of bioplastic poly-3-hydroxybutyrate (PHB) in the absence of yeast extract, nitrogen and phosphorus sources as well as trace elements. This reduces the PHB production cost significantly. Furthermore, acetic acid formed from anaerobic fermentation of heat lysed activated sludge can be used to replace glucose for cell growth but not much for PHB production. After construction of an additional PHB synthesis pathway in Halomonas CJN, we can produce PHB entirely from heat lysed activated sludge, reducing production cost of PHB roughly from ¥ 30 000 Yuan/ton to ¥ 20 000 Yuan/ton, thus turning waste activated sludge to valuable raw material resource.

  20. Influence of turning Treatments on Al6061 by Offline Inspection Technique

    Science.gov (United States)

    Annigeri, Ulhas K.; Sandeep, K. L. G.; Prasanna Chaitanya, M.; Sairam Varma, G.; Datta, B. Arun

    2018-02-01

    Aluminium is mostly extracted from bauxite and is frequently being utilised in the manufacture of sea, land and air vehicles. Since, it has the merit of resistance to corrosion it is frequently being used in sea vehicles. Another outstanding merit of aluminium is its weight which is very less compared to other ferrous materials. In our study, we have selected Al6061 as the material and based on full factorial design the surface roughness has been observed with three base parameters speed, feed and depth of cut. A mathematical model has been developed to predict the surface roughness and also the dominant factor affecting the turning process has been determined. The plots such as main effects, interaction and Pareto chart have been analysed to give an effective conclusion to the process followed in the study. The purpose of these experiments to compare the effect of process treatments in all possible pairs to select the best treatment to the process has been done satisfactorily.

  1. Identification of helix capping and β-turn motifs from NMR chemical shifts

    International Nuclear Information System (INIS)

    Shen Yang; Bax, Ad

    2012-01-01

    We present an empirical method for identification of distinct structural motifs in proteins on the basis of experimentally determined backbone and 13 C β chemical shifts. Elements identified include the N-terminal and C-terminal helix capping motifs and five types of β-turns: I, II, I′, II′ and VIII. Using a database of proteins of known structure, the NMR chemical shifts, together with the PDB-extracted amino acid preference of the helix capping and β-turn motifs are used as input data for training an artificial neural network algorithm, which outputs the statistical probability of finding each motif at any given position in the protein. The trained neural networks, contained in the MICS (motif identification from chemical shifts) program, also provide a confidence level for each of their predictions, and values ranging from ca 0.7–0.9 for the Matthews correlation coefficient of its predictions far exceed those attainable by sequence analysis. MICS is anticipated to be useful both in the conventional NMR structure determination process and for enhancing on-going efforts to determine protein structures solely on the basis of chemical shift information, where it can aid in identifying protein database fragments suitable for use in building such structures.

  2. Identification of helix capping and {beta}-turn motifs from NMR chemical shifts

    Energy Technology Data Exchange (ETDEWEB)

    Shen Yang; Bax, Ad, E-mail: bax@nih.gov [National Institutes of Health, Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases (United States)

    2012-03-15

    We present an empirical method for identification of distinct structural motifs in proteins on the basis of experimentally determined backbone and {sup 13}C{sup {beta}} chemical shifts. Elements identified include the N-terminal and C-terminal helix capping motifs and five types of {beta}-turns: I, II, I Prime , II Prime and VIII. Using a database of proteins of known structure, the NMR chemical shifts, together with the PDB-extracted amino acid preference of the helix capping and {beta}-turn motifs are used as input data for training an artificial neural network algorithm, which outputs the statistical probability of finding each motif at any given position in the protein. The trained neural networks, contained in the MICS (motif identification from chemical shifts) program, also provide a confidence level for each of their predictions, and values ranging from ca 0.7-0.9 for the Matthews correlation coefficient of its predictions far exceed those attainable by sequence analysis. MICS is anticipated to be useful both in the conventional NMR structure determination process and for enhancing on-going efforts to determine protein structures solely on the basis of chemical shift information, where it can aid in identifying protein database fragments suitable for use in building such structures.

  3. Microcystis extracts and single cells have differential impacts on the demography of cladocerans: a case study on Moina cf. micrura isolated from the Mediterranean coastal shallow lake (L'Albufera, Spain)

    NARCIS (Netherlands)

    Nandini, S.; Miracle, M. R.; Vicente, E.; Sarma, S. S. S.; Gulati, R. D.

    2017-01-01

    Cyanobacteria often have a deleterious effect on zooplankton. We hypothesized that the presence of either M. aeruginosa cells or microcystin extracts from M. aeruginosa would have a significant impact on the population growth rate, survivorship, and fecundity of Moina cf. micrura isolated from

  4. Medium dependent dual turn on/turn off fluorescence sensing for Cu2+ions using AMI/SDS assemblies.

    Science.gov (United States)

    Gujar, Varsha B; Ottoor, Divya

    2017-02-15

    Behavior of Amiloride (AMI) as a metal ion sensor in anionic surfactant assemblies of varying concentrations at different pH is depicted in this work. From a non-sensor fluorophore, AMI has been transformed in to a tunable fluorosensor for Cu 2+ ions in various SDS concentrations. At premicellar concentration of SDS, ion-pair complex is expected to be formed between AMI and SDS due to electrostatic interactions between them. However at CMC concentrations of SDS, fluorescence intensity of AMI is greatly enhanced with red shift in emission, due to the incorporation of AMI molecule in the hydrophobic micellar interface. The behavior of metal sensing by AMI-SDS assemblies gives rise to several interesting observations. Micellation of SDS has been greatly enhanced by increasing copper ion concentrations, as these counter ions screens the charge on monomers of SDS which lead to the aggregation at premicellar concentrations only. Concentrations and pH dependent discrete trends of interactions between SDS-AMI and SDS-Cu 2+ ions, have given tunable fluorescence responses (fluorescence turn on/turn off) of AMI for added Cu 2+ ions. The electrostatic interaction between the metal cations and the anionic surfactants is the driving force for bringing the metal ions near to the vicinity of micelle where AMI resides. Thus, a comprehensive understanding of the mechanism related to the 'turn on-turn off' fluorescence response of AMI with respect to pH and SDS concentration for effective Cu 2+ ion sensing is illustrated in this work. Copyright © 2016 Elsevier B.V. All rights reserved.

  5. Simulation of turn-by-turn passage of protons through the H-minus stripping foil in booster

    Energy Technology Data Exchange (ETDEWEB)

    Gardner, C. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2017-07-06

    Equations for transverse emittance growth due to multiple passes of circulating proton beam through the H-minus stripping foil in Booster were developed in [1]. These were based on simple principles of statistics and simple assumptions about the initial distribution of particles incident on the foil. It was assumed there that the foil dimensions and position of the incoming beam are such that all particles hit the foil on every turn around the machine. In the present note we assume only that all incoming H-minus ions from Linac hit the foil and are stripped of their electrons. The resulting protons circulate indefinitely around the machine. Setups in which the foil width is reduced so that not all protons hit the foil on every turn are studied here by simulation. The aim is to determine the effectiveness of such setups in reducing the emittance growth of circulating proton beam during the injection of H-minus beam. The simulations also serve as a check of the equations developed in [1], and vice versa. The particulars of the simulation setup are given in Sections 1 through 11. Figures 1 through 12 show simulation results for the case in which all particles hit the foil on every turn. The results are in good agreement with those obtained from the equations of reference [1]. Figures 13 through 19 show simulation results for various setups in which the foil width is reduced. These results are summarized in Section 12. In all gures the horizontal axis gives the turn number. The unit of the vertical axis is micrometers ( m) in all plots of emittance.

  6. A falling of the veils: turning points and momentous turning points in leadership and the creation of CSR

    OpenAIRE

    Hemingway, C.; Starkey, Kenneth

    2017-01-01

    This article uses the life stories approach to leadership and leadership development. Using exploratory, qualitative data from a Forbes Global 2000 and FTSE 100 company, we discuss the role of the turning point (TP) as an important antecedent of leadership in corporate social responsibility. We argue that TPs are causally efficacious, linking them to the development of life narratives concerned with an evolving sense of personal identity. Using both a multi-disciplinary perspective and a mult...

  7. Inflation of Unreefed and Reefed Extraction Parachutes

    Science.gov (United States)

    Ray, Eric S.; Varela, Jose G.

    2015-01-01

    Data from the Orion and several other test programs have been used to reconstruct inflation parameters for 28 ft Do extraction parachutes as well as the parent aircraft pitch response during extraction. The inflation force generated by extraction parachutes is recorded directly during tow tests but is usually inferred from the payload accelerometer during Low Velocity Airdrop Delivery (LVAD) flight test extractions. Inflation parameters are dependent on the type of parent aircraft, number of canopies, and standard vs. high altitude extraction conditions. For standard altitudes, single canopy inflations are modeled as infinite mass, but the non-symmetric inflations in a cluster are modeled as finite mass. High altitude extractions have necessitated reefing the extraction parachutes, which are best modeled as infinite mass for those conditions. Distributions of aircraft pitch profiles and inflation parameters have been generated for use in Monte Carlo simulations of payload extractions.

  8. Assessment of the rate of premolar extraction space closure in the maxillary arch with the AcceleDent Aura appliance vs no appliance in adolescents: A single-blind randomized clinical trial.

    Science.gov (United States)

    Miles, Peter; Fisher, Elizabeth; Pandis, Nikolaos

    2018-01-01

    The purpose of this 2-arm parallel trial was to assess the effect of the AcceleDent Aura appliance (OrthoAccel Technologies, Houston, Tex) on the rate of maxillary premolar extraction space closure in adolescent patients. Forty Class II adolescents treated with full fixed appliances and maxillary premolar extractions participated in this randomized clinical trial. They were recruited in a private practice and treated by 1 clinician. Randomization was accomplished in blocks of 10 patients assigned to either a no-appliance group or the AcceleDent Aura appliance group with the allocations concealed in opaque, sealed envelopes. Both the operator and the outcome assessor were blinded; however, it was not feasible to blind the patients. Models were taken of the maxillary arch at the start of space closure and just before complete space closure. The space was measured parallel to the occlusal plane from the cusp tips of the teeth mesial and distal to the extraction spaces. There was no clinically (0.05 mm per month; 95% confidence interval [CI], -0.24, 0.34) or statistically significant difference in the rate of space closure (P = 0.74). In both the univariable and multivariable analyses, the mean rate of tooth movement was slower by 0.13 mm per month (95% CI, -.26, .005) on the left side compared with the right side, but this was not statistically significant (P = 0.06). The AcceleDent Aura appliance had no effect on the rate of maxillary premolar extraction space closure. Only a few participants were considered to be good compliers with the appliance. However, the rate of space closure in the good compliers was similar to the overall group and did not appear to influence the result. This trial was not registered. The protocol was not published before trial commencement. Copyright © 2017 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.

  9. The Opportunities and Threats of Turning Airports into Hubs

    Science.gov (United States)

    Kraus, Andreas; Koch, Benjamin

    2006-01-01

    This paper examines the opportunities and threats which arise when turning origin/destination airports into hubs. The analysis focuses on market development trends, competitive structures, especially in the light of airline network strategies and the growing rivalry between airports, and finally the potential financial impacts for the airport, including both investment efforts and the financial results from hub operations. We argue that in most cases a decision against converting a traditional origin/destination airport into a major transfer point is preferable to the transformation into a hub.

  10. Varieties of publication patterns in neuroscience at the cognitive turn.

    Science.gov (United States)

    Christen, Markus

    2008-01-01

    The quantification of publication activity and impact has become a key element in the evaluation of scientific excellence. However, it is unclear to what extent this grasps the diversity of research communication that accompanies the transition of scientific fields. This contribution investigates number, categorization, and impact of publications (i.e., publication patterns) of six scientists active at the cognitive turn, which promoted the information processing perspective on neuronal processes in different communities: Horace Barlow, Theodore Bullock, Ralph Gerard, Donald MacKay, Warren McCulloch, and Werner Reichardt. The large variety of publication patterns revealed indicates the limits of standardized evaluation procedures based on publication activity.

  11. Turning a Poor Ion Channel into a Good Pump

    Science.gov (United States)

    Astumian, Dean

    2003-05-01

    We consider a membrane protein that can exist in two configurations, either one of which acts as a poor ion channel, allowing ions to slowly leak across the membrane from high to low elctrochemical potential. We show that random external fluctuations can provide the energy to turn this poor channel into a good pump that drives ion transport from low to high electrochemical potential. We discuss this result in terms of a gambling analogy, and point to possible implications for fields as far ranging as population biology, economics, and actuarial science.

  12. Why nature doesn't turn off neurosis.

    Science.gov (United States)

    Badalamenti, Anthony F

    2013-03-01

    This paper develops an integration of psychoanalytic and wisdom tradition concepts to answer the question as to why nature does not turn off neurosis, The proposed answer is that nature wants a person to exploit the neurosis for two gains, one being the increase in adaptive capacity resulting from releasing it and the second involving the difficulty in the release itself, the latter related to gains proffered by the world's wisdom traditions. These see a movement from the psyche's creation by passive, unconscious means of finite promise rooted in parental love to creation by active, consciously chosen means of unlimited promise involving a direct relationship with nature and the Cosmos.

  13. Big data analytics turning big data into big money

    CERN Document Server

    Ohlhorst, Frank J

    2012-01-01

    Unique insights to implement big data analytics and reap big returns to your bottom line Focusing on the business and financial value of big data analytics, respected technology journalist Frank J. Ohlhorst shares his insights on the newly emerging field of big data analytics in Big Data Analytics. This breakthrough book demonstrates the importance of analytics, defines the processes, highlights the tangible and intangible values and discusses how you can turn a business liability into actionable material that can be used to redefine markets, improve profits and identify new business opportuni

  14. The embodied turn in research on language and social interaction

    DEFF Research Database (Denmark)

    Nevile, Maurice

    2015-01-01

    I use the term the embodied turn to mean the point when interest in the body became established among researchers on language and social interaction, exploiting the greater ease of video-recording. This review paper tracks the growth of "embodiment" in over 400 papers published in Research...... on Language and Social Interaction from 1987-2013. I consider closely two areas where analysts have confronted challenges, and how they have responded: settling on precise and analytically helpful terminology for the body; and transcribing and representing the body, particularly its temporality and manner....

  15. Tool life of ceramic wedges during precise turning of tungsten

    Directory of Open Access Journals (Sweden)

    Legutko Stanislaw

    2017-01-01

    Full Text Available Properties, application and machinability of tungsten and its alloys have been demonstrated. The comparison of the tool life and wear of the wedges made of SiAlON and whisker ceramics during the precise turning at different cutting parameters have been presented. The CNC lathe DMG CTX 310 Ecoline and tungsten of 99.7 % purity were used during the experiments. Only the wedge of whisker ceramics has proved to be sufficiently suitable and only for relatively low cutting speeds.

  16. Serials cataloging at the turn of the century

    CERN Document Server

    Williams, James W

    2014-01-01

    An overview of the research topics and trends that have appeared over the last five years, Serials Cataloging at the Turn of the Century doesn't just tell you that there has been a lot of change--that the information environment is something of a chameleon, always beguiling and slipping out of grasp. Instead, it gives you the plain facts on the specific challenges serials catalogers have been facing and how they're meeting adversity head-on, ready to gain the advantage in the rumble with proliferating information and formats.Comprehensive, resource-packed, and easy-to-digest, Serials Catalogin

  17. Orbiter 'Enterprise' turns and banks during second ALT

    Science.gov (United States)

    1977-01-01

    The Orbiter 101 'Enterprise' makes a turn and bank maneuver during the second free flight of the Shuttle Apporach and Landing Tests (ALTs) conducted on September 13, 1977 at Dryden Flight Research Center in Southern California. The 'Enterprise' separated form the NASA 747 carrier aircraft and after a five-minute, 28-second unpowered flight landed on a runway below. Astronauts Joe H. Engle, and Richard H. Truly were the crew of the 'Enterprise.' The ALT free flights are designed to verify Orbiter subsonic airworthiness, integrated systems operations and pilot-guided approach and landing capability and satisfying prerequisites to automatic flight control and navigation mode.

  18. Turn and jump: how time & place fell apart

    CERN Document Server

    Mansfield, Howard

    2013-01-01

    Before Thomas Edison, light and fire were thought to be one and the same. Turns out, they were separate things altogether. This book takes a similar relationship, that of time and place, and shows how they, too, were once inseparable. Time keeping was once a local affair, when small towns set their own pace according to the rising and setting of the sun. Then, in 1883, the expanding railroads necessitated the creation of Standard Time zones, and communities became linked by a universal time. Here Howard Mansfield explores how our sudden interconnectedness, both physically, as through the railroad, and through inventions like the telegraph, changed our concept of time and place forever.

  19. Direct conversion of inulin and extract of tubers of Jerusalem artichoke into single cell oil by co-cultures of Rhodotorula mucilaginosa TJY15a and immobilized inulinase-producing yeast cells.

    Science.gov (United States)

    Zhao, Chun-Hai; Chi, Zhe; Zhang, Fang; Guo, Feng-Jun; Li, Mei; Song, Wei-Bo; Chi, Zhen-Ming

    2011-05-01

    In this study, it was found that the immobilized inulinase-producing cells of Pichia guilliermondii M-30 could produce 169.3 U/ml of inulinase activity while the free cells of the same yeast strain only produced 124.3 U/ml of inulinase activity within 48 h. When the immobilized inulinase-producing yeast cells were co-cultivated with the free cells of Rhodotorula mucilaginosa TJY15a, R. mucilaginosa TJY15a could accumulate 53.2% oil from inulin in its cells and cell dry weight reached 12.2g/l. Under the similar conditions, R. mucilaginosa TJY15a could accumulate 55.4% (w/w) oil from the extract of Jerusalem artichoke tubers in its cells and cell dry weight reached 12.8 g/l within 48 h. When the co-cultures were grown in 2l fermentor, R. mucilaginosa TJY15a could accumulate 56.6% (w/w) oil from the extract of Jerusalem artichoke tubers in its cells and cell dry weight reached 19.6g/l within 48 h. Over 90.0% of the fatty acids from the yeast strain TJY15a grown in the extract of Jerusalem artichoke tubers was C(16:0), C(18:1) and C(18:2), especially C(18:1) (50.6%). Copyright © 2011 Elsevier Ltd. All rights reserved.

  20. Initiating Interactive Turn Spaces in Japanese Conversation: Local Projection and Collaborative Action

    Science.gov (United States)

    Iwasaki, Shimako

    2009-01-01

    Shifting from a focus on transitions between speakers at turn boundaries, this study examines projective and multimodal structures "inside" a turn-constructional unit (TCU), out of which any turn is built. It analyzes how particular noun-phrasal components within a TCU become projective and shape interactive turn spaces (ITSs) where…

  1. Model-based chatter stability prediction and detection for the turning of a flexible workpiece

    Science.gov (United States)

    Lu, Kaibo; Lian, Zisheng; Gu, Fengshou; Liu, Hunju

    2018-02-01

    Machining long slender workpieces still presents a technical challenge on the shop floor due to their low stiffness and damping. Regenerative chatter is a major hindrance in machining processes, reducing the geometric accuracies and dynamic stability of the cutting system. This study has been motivated by the fact that chatter occurrence is generally in relation to the cutting position in straight turning of slender workpieces, which has seldom been investigated comprehensively in literature. In the present paper, a predictive chatter model of turning a tailstock supported slender workpiece considering the cutting position change during machining is explored. Based on linear stability analysis and stiffness distribution at different cutting positions along the workpiece, the effect of the cutting tool movement along the length of the workpiece on chatter stability is studied. As a result, an entire stability chart for a single cutting pass is constructed. Through this stability chart the critical cutting condition and the chatter onset location along the workpiece in a turning operation can be estimated. The difference between the predicted tool locations and the experimental results was within 9% at high speed cutting. Also, on the basis of the predictive model the dynamic behavior during chatter that when chatter arises at some cutting location it will continue for a period of time until another specified location is arrived at, can be inferred. The experimental observation is in good agreement with the theoretical inference. In chatter detection respect, besides the delay strategy and overlap processing technique, a relative threshold algorithm is proposed to detect chatter by comparing the spectrum and variance of the acquired acceleration signals with the reference saved during stable cutting. The chatter monitoring method has shown reliability for various machining conditions.

  2. Ultra-precision turning of complex spiral optical delay line

    Science.gov (United States)

    Zhang, Xiaodong; Li, Po; Fang, Fengzhou; Wang, Qichang

    2011-11-01

    Optical delay line (ODL) implements the vertical or depth scanning of optical coherence tomography, which is the most important factor affecting the scanning resolution and speed. The spinning spiral mirror is found as an excellent optical delay device because of the high-speed and high-repetition-rate. However, it is one difficult task to machine the mirror due to the special shape and precision requirement. In this paper, the spiral mirror with titled parabolic generatrix is proposed, and the ultra-precision turning method is studied for its machining using the spiral mathematic model. Another type of ODL with the segmental shape is also introduced and machined to make rotation balance for the mass equalization when scanning. The efficiency improvement is considered in details, including the rough cutting with the 5- axis milling machine, the machining coordinates unification, and the selection of layer direction in turning. The onmachine measuring method based on stylus gauge is designed to analyze the shape deviation. The air bearing is used as the measuring staff and the laser interferometer sensor as the position sensor, whose repeatability accuracy is proved up to 10nm and the stable feature keeps well. With this method developed, the complex mirror with nanometric finish of 10.7nm in Ra and the form error within 1um are achieved.

  3. Beyond Cultural History? The Material Turn, Praxiography, and Body History

    Directory of Open Access Journals (Sweden)

    Iris Clever

    2014-10-01

    Full Text Available The body came to be taken seriously as a topic of cultural history during the “corporeal” or “bodily” turn in the 1980s and 1990s. Soon, however, critique was raised against these studies’ conceptualization of the body as discursively shaped and socially disciplined: individual bodily agency and feeling were felt to be absent in the idea of the material body. This article critically analyzes new approaches in the field of body history, particularly the so-called “material turn”. It argues that the material turn, especially in the guise of praxiography, has a lot to offer historians of the body, such as more attention to material practices, to different kinds of actors and a more open eye to encounters. Potential problems of praxiographical analyses of the body in history include the complicated relationship between discourses and practices and the neglect of the political and feminist potential of deconstructive discourse analyses. However, a focus on the relationship between practices of knowledge production and the representation of the body may also provide new ways of opening up historical power relations.

  4. Development of a Low Cost MQL Setup for Turning Operations

    Directory of Open Access Journals (Sweden)

    Islam Sumaiya

    2017-01-01

    Full Text Available In this study, the effect of MQL application on the tool wear, surface roughness and chip formation in turning Aluminum alloy 6061 is investigated. Experiments were carried out by plain turning of an Aluminum bar with varying depth of cut, cutting speeds (spindle speed and cutting environments (Dry, Wet and MQL. A newly designed, cost efficient and portable MQL setup was developed for this study. For each experimental trial, five passes were carried out in order to promote the formation of tool wear. After each pass, the tool surface was examined under a microscope and the surface roughness was measured using a stylus based surface tester. The extent of tool wear from each pass is measured by using ImageJ software. Chips were collected after the five passes and were physically examined. The newly designed MQL delivery system was successful in delivering a fine mist of lubricant at the cutting point. MQL lubrication provided lower surface roughness and tool wear values compared to wet and dry conditions due to effective temperature reduction and improved lubrication penetration of cutting zones, as well as better chip flushing. Chip formed under MQL conditions had reduced chip thickness due to reduced temperatures. MQL was found to have the greatest positive impact on tool wear and surface roughness parameters based on ANOVA results.

  5. Energy-Based Analysis of Ultrasonically Assisted Turning

    Directory of Open Access Journals (Sweden)

    G.A. Volkov

    2011-01-01

    Full Text Available The process of ultrasonically-assisted turning (UAT is a superposition of vibration of a cutting tool on its standard movement in conventional turning (CT. The former technique has several advantages compared with the latter, one of the main being a significant decrease in the level of cutting forces. In this paper the effects observed in UAT are analysed employing ideas of dynamic fracture mechanics. The active stage of loading duration depends heavily on ultrasonic frequency and the cutting speed; he application of the fracture criterion based on the notion of incubation time makes it possible to calculate a dependence of this duration on its threshold amplitude. An estimation of energy, necessary to create a threshold pulse in the material, is made by solving the contact Hertz problem. The obtained time dependence of energy has a marked minimum. Thus, the existence of energy-efficient loading duration is demonstrated. This explains the decrease in the cutting force resulting from superimposed ultrasonic vibration. The obtained results are in agreement with experiments on ultrasonic assisted machining of aluminium and Inconel 718 alloy.

  6. Surface roughness when diamond turning RSA 905 optical aluminium

    Science.gov (United States)

    Otieno, T.; Abou-El-Hossein, K.; Hsu, W. Y.; Cheng, Y. C.; Mkoko, Z.

    2015-08-01

    Ultra-high precision machining is used intensively in the photonics industry for the production of various optical components. Aluminium alloys have proven to be advantageous and are most commonly used over other materials to make various optical components. Recently, the increasing demand from optical systems for optical aluminium with consistent material properties has led to the development of newly modified grades of aluminium alloys produced by rapid solidification in the foundry process. These new aluminium grades are characterised by their finer microstructures and refined mechanical and physical properties. However the machining database of these new optical aluminium grades is limited and more research is still required to investigate their machinability performance when they are diamond turned in ultrahigh precision manufacturing environment. This work investigates the machinability of rapidly solidified aluminium RSA 905 by varying a number of diamond-turning cutting parameters and measuring the surface roughness over a cutting distance of 4 km. The machining parameters varied in this study were the cutting speed, feed rate and depth of cut. The results showed a common trend of decrease in surface roughness with increasing cutting distance. The lowest surface roughness Ra result obtained after 4 km in this study was 3.2 nm. This roughness values was achieved using a cutting speed of 1750 rpm, feed rate of 5 mm/min and depth of cut equal to 25 μm.

  7. SURFACE INTEGRITY EVALUATION OF TURNING WITH AUTO-ROTATING TOOL

    Directory of Open Access Journals (Sweden)

    Jozef Struharnansky

    2016-09-01

    Full Text Available The technical practice requirements comes to have increased demands on higher productivity, speed and quality of the machining process of various materials. Hard to machine materials, whose machining led to the development of turning with rotating cutting edge are not an exception. The machining process of auto-rotating tool is more complicated than the conventional process of turning, especially for the process of reshaping cutting layers into chips. There is a significant load in the system, that may affect the life of the cutting edge of the tool as well as the whole system and also in the final extent of the qualitative parameters of the workpiece (product / product. The article specifies the knowledge and findings of measurement in machining material 100Cr6 with an auto-rotating tool. The measurements were conducted to evaluate the integrity of the surface (roughness of the workpiece to the impacts of cutting conditions, in particular the feed and the cutting edge inclination. It also analyzes the presence (size, character, action of residual stresses concentrated in the surface layers of the workpiece by changing the cutting conditions.

  8. Machining parameter optimization in turning process for sustainable manufacturing

    Directory of Open Access Journals (Sweden)

    S. G. Dambhare

    2015-09-01

    Full Text Available There is an increase in awareness about sustainable manufacturing process. Manufacturing industries are backbone of a country’s economy. Although it is important but there is a great concern about consumption of resources and waste creation. The primary aim of this study was to explore sustainability concern in turning process in an Indian machining industry. The effect of cutting parameters, Speed/Feed/Depth of Cut, the machining environment, Dry/MQL/Wet, and the type of cutting tool on sustainability factors under study were observed. Analysis of Variance (ANOVA was used to analyse the data obtained from experimentation in a small scale machining industry. The process is modelled mathematically using response surface methodology (RSM.The economic and environmental aspect like surface roughness, material removal rate and energy consumption were considered as sustainability factors. The model helps to understand the effect of the cutting parameters and conditions on surface finish, energy consumption, and material removal rate. The process was optimized for minimum power consumption considering environmental concern as prime importance. Studies suggest that the cutting environment and tool type influenced on the power consumption during turning process. Extended form of the proposed model could be useful to predict the environmental impact due to machining process, which would bring environmental concern into conventional machining.

  9. NetTurnP – Neural Network Prediction of Beta-turns by Use of Evolutionary Information and Predicted Protein Sequence Features

    DEFF Research Database (Denmark)

    Petersen, Bent; Lundegaard, Claus; Petersen, Thomas Nordahl

    2010-01-01

    is the highest reported performance on a two-class prediction of β-turn and not-β-turn. Furthermore NetTurnP shows improved performance on some of the specific β-turn types. In the present work, neural network methods have been trained to predict β-turn or not and individual β-turn types from the primary amino......β-turns are the most common type of non-repetitive structures, and constitute on average 25% of the amino acids in proteins. The formation of β-turns plays an important role in protein folding, protein stability and molecular recognition processes. In this work we present the neural network method...... NetTurnP, for prediction of two-class β-turns and prediction of the individual β-turn types, by use of evolutionary information and predicted protein sequence features. It has been evaluated against a commonly used dataset BT426, and achieves a Matthews correlation coefficient of 0.50, which...

  10. Turning gene function ON and OFF using sense and antisense photo-morpholinos in zebrafish

    Science.gov (United States)

    Tallafuss, Alexandra; Gibson, Dan; Morcos, Paul; Li, Yongfu; Seredick, Steve; Eisen, Judith; Washbourne, Philip

    2012-01-01

    To understand the molecular mechanisms of development it is essential to be able to turn genes on and off at will and in a spatially restricted fashion. Morpholino oligonucleotides (MOs) are very common tools used in several model organisms with which it is possible to block gene expression. Recently developed photo-activated MOs allow control over the onset of MO activity. However, deactivation of photo-cleavable MO activity has remained elusive. Here, we describe photo-cleavable MOs with which it is possible to activate or de-activate MO function by UV exposure in a temporal and spatial manner. We show, using several different genes as examples, that it is possible to turn gene expression on or off both in the entire zebrafish embryo and in single cells. We use these tools to demonstrate the sufficiency of no tail expression as late as tailbud stage to drive medial precursor cells towards the notochord cell fate. As a broader approach for the use of photo-cleavable MOs, we show temporal control over gal4 function, which has many potential applications in multiple transgenic lines. We demonstrate temporal manipulation of Gal4 transgene expression in only primary motoneurons and not secondary motoneurons, heretofore impossible with conventional transgenic approaches. In another example, we follow and analyze neural crest cells that regained sox10 function after deactivation of a photo-cleavable sox10-MO at different time points. Our results suggest that sox10 function might not be critical during neural crest formation. PMID:22492359

  11. Turning gene function ON and OFF using sense and antisense photo-morpholinos in zebrafish.

    Science.gov (United States)

    Tallafuss, Alexandra; Gibson, Dan; Morcos, Paul; Li, Yongfu; Seredick, Steve; Eisen, Judith; Washbourne, Philip

    2012-05-01

    To understand the molecular mechanisms of development it is essential to be able to turn genes on and off at will and in a spatially restricted fashion. Morpholino oligonucleotides (MOs) are very common tools used in several model organisms with which it is possible to block gene expression. Recently developed photo-activated MOs allow control over the onset of MO activity. However, deactivation of photo-cleavable MO activity has remained elusive. Here, we describe photo-cleavable MOs with which it is possible to activate or de-activate MO function by UV exposure in a temporal and spatial manner. We show, using several different genes as examples, that it is possible to turn gene expression on or off both in the entire zebrafish embryo and in single cells. We use these tools to demonstrate the sufficiency of no tail expression as late as tailbud stage to drive medial precursor cells towards the notochord cell fate. As a broader approach for the use of photo-cleavable MOs, we show temporal control over gal4 function, which has many potential applications in multiple transgenic lines. We demonstrate temporal manipulation of Gal4 transgene expression in only primary motoneurons and not secondary motoneurons, heretofore impossible with conventional transgenic approaches. In another example, we follow and analyze neural crest cells that regained sox10 function after deactivation of a photo-cleavable sox10-MO at different time points. Our results suggest that sox10 function might not be critical during neural crest formation.

  12. A comparative study on performance of CBN inserts when turning steel under dry and wet conditions

    Science.gov (United States)

    Abdullah Bagaber, Salem; Razlan Yusoff, Ahmad

    2017-10-01

    Cutting fluids is the most unsustainable components of machining processes, it is negatively impacting on the environmental and additional energy required. Due to its high strength and corrosion resistance, the machinability of stainless steel has attracted considerable interest. This study aims to evaluate performance of cubic boron nitride (CBN) inserts for the machining parameters includes the power consumption and surface roughness. Due to the high single cutting-edge cost of CBN, the performance of significant is importance for hard finish turning. The present work also deals with a comparative study on power consumption and surface roughness under dry and flood conditions. Turning process of the stainless steel 316 was performed. A response surface methodology based box-behnken design (BBD) was utilized for statistical analysis. The optimum process parameters are determined as the overall performance index. The comparison study has been done between dry and wet stainless-steel cut in terms of minimum value of energy and surface roughness. The result shows the stainless still can be machined under dry condition with 18.57% improvement of power consumption and acceptable quality compare to the wet cutting. The CBN tools under dry cutting stainless steel can be used to reduce the environment impacts in terms of no cutting fluid use and less energy required which is effected in machining productivity and profit.

  13. Single solid phase extraction method for the simultaneous analysis of polar and non-polar pesticides in urine samples by gas chromatography and ultra high pressure liquid chromatography coupled to tandem mass spectrometry.

    Science.gov (United States)

    Cazorla-Reyes, Rocío; Fernández-Moreno, José Luis; Romero-González, Roberto; Frenich, Antonia Garrido; Vidal, José Luis Martínez

    2011-07-15

    A new multiresidue method has been developed and validated for the simultaneous extraction of more than two hundred pesticides, including non-polar and polar pesticides (carbamates, organochlorine, organophosphorous, pyrethroids, herbicides and insecticides) in urine at trace levels by gas and ultra high pressure liquid chromatography coupled to ion trap and triple quadrupole mass spectrometry, respectively (GC-IT-MS/MS, UHPLC-QqQ-MS/MS). Non-polar and polar pesticides were simultaneously extracted from urine samples by a simple and fast solid phase extraction (SPE) procedure using C(18) cartridges as sorbent, and dichloromethane as elution solvent. Recovery was in the range of 60-120%. Precision values expressed as relative standard deviation (RSD) were lower than 25%. Identification and confirmation of the compounds were performed by the use of retention time windows, comparison of spectra (GC-amenable compounds) or the estimation of the ion ratio (LC-amenable compounds). For GC-amenable pesticides, limits of detection (LODs) ranged from 0.001 to 0.436 μg L(-1) and limits of quantification (LOQs) from 0.003 to 1.452 μg L(-1). For LC-amenable pesticides, LODs ranged from 0.003 to 1.048 μg L(-1) and LOQs ranged from 0.011 to 3.494 μg L(-1). Finally, the optimized method was applied to the analysis of fourteen real samples of infants from agricultural population. Some pesticides such as methoxyfenozide, tebufenozide, piperonyl butoxide and propoxur were found at concentrations ranged from 1.61 to 24.4 μg L(-1), whereas methiocarb sulfoxide was detected at trace levels in two samples. Copyright © 2011 Elsevier B.V. All rights reserved.

  14. Where Could an Anthropological Turn Lead the Humanities and the Arts

    Directory of Open Access Journals (Sweden)

    Hans Ulrich Gumbrecht

    2012-05-01

    Full Text Available This paper discusses the possible significations of a so-called anthropological turn in the field of the Humanities and Arts. The text focuses on the meaning of Anthropology and its application in these fields. In this sense, two great conceptions of Anthropology are distinguished: an understanding of Anthropology as an attempt at a singular, meta-historical and transcultural determination of a valid definition of what it means to be human; and another whose use predominates in the Anglo-American contemporary context, in which different ways of being human are considered, instead of a single conception. The text also discusses the word ‘reviravolta’ [overturn] which the Humanities and the Arts have been trying to point out and identify as what is or should be the contemporary thought in those fields.

  15. Analysis of single biological cells

    International Nuclear Information System (INIS)

    Watt, Frank

    2002-01-01

    The extraction of elemental information from single cultured cells using nuclear microscopy is an area of great potential because it can provide both quantitative information on the uptake of elements by the cell, and also its elemental response to a wide variety of external stimuli. A recent technique based on nuclear physics technology enables the analysis of single cells down to the parts per million level to be achieved

  16. Solvent Extraction of Pr and Nd from Chloride Solution by Mixtures of Acidic Extractants and LIX 63

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Yang; Lee, Man Seung [Mokpo National University, Chonnam (Korea, Republic of); Jeon, Ho Seok [Korea Institute of Geoscience and Mineral Resources (KIGAM), Daejon (Korea, Republic of)

    2016-08-15

    Mixtures of acidic extractants and LIX 63 were employed to improve the extraction efficiency of Pr and Nd from chloride solutions. The effect of the composition of the extractant mixtures has been studied. The order of metal extraction by single acidic extractant was D2EHPA > PC88A > Cyanex 272 > Cyanex 301. The addition of LIX 63 to the acidic extractants resulted in a synergistic effect, and the strength of the effect was the reverse order of that found for extraction by single extractants. Moreover, mixing of saponified Cyanex 272 and LIX 63 enhanced the extraction, while the addition of Alamine 336 to the mixtures of Cyanex 272 and LIX 63 depressed the extraction.

  17. Optical characteristics of two electrode and three electrode extraction system of an ECR-ion source

    International Nuclear Information System (INIS)

    Siljegovic, M.; Dobrosavljevic, A.

    2001-01-01

    Two extraction systems, single gap extraction system and accel-decel three electrode extraction system, are investigated. The extraction of ions from ECR-sources is usually done in a single extraction gap. But, this type of extraction system has the disadvantage of a low flexibility during operation. In the case of accel-decel system, optimisation of its optical characteristics, in respect to certain ion species, is simply performed by changing the negative potential on the screening electrode (author)

  18. Supercritical fluid extraction (SFE) of ketamine metabolites from dried urine and on-line quantification by supercritical fluid chromatography and single mass detection (on-line SFE-SFC-MS).

    Science.gov (United States)

    Hofstetter, Robert; Fassauer, Georg M; Link, Andreas

    2018-02-15

    On-line solid-phase supercritical fluid extraction (SFE) and chromatography (SFC) coupled to mass spectrometry (MS) has been evaluated for its usefulness with respect to metabolic profiling and pharmacological investigations of ketamine in humans. The aim of this study was to develop and validate a rapid, highly selective and sensitive SFE-SFC-MS method for the quantification of ketamine and its metabolites in miniature amounts in human urine excluding liquid-liquid extraction (LLE). Several conditions were optimized systematically following the requirements of the European Medicines Agency: selectivity, carry-over, calibration curve parameters (LLOQ, range and linearity), within- and between-run accuracy and precision, dilution integrity, matrix effect, and stability. The method, which required a relatively small volume of human urine (20 μL per sample), was validated for pharmacologically and toxicologically relevant concentrations ranging from 25.0 to 1000 ng/mL (r 2  > 0.995). The lower limit of quantification (LLOQ) for all compounds was found to be as low as 0.5 ng. In addition, stability of analytes during removal of water from the urine samples using different conditions (filter paper or ISOLUTE® HM-N) was studied. In conclusion, the method developed in this study can be successfully applied to studies of ketamine metabolites in humans, and may pave the way for routine application of on-line SFE-SFC-MS in clinical investigations. Copyright © 2018 Elsevier B.V. All rights reserved.

  19. O turning point da grande reportagem multimídia

    OpenAIRE

    Longhi, Raquel Ritter; Universidade Federal de Santa Catarina / Campus Reitor João David Ferreira Lima. Florianópolis, Santa Catarina. Brasil. CEP: 88049-900 Tel: (48) 3721.9000

    2015-01-01

    Este artigo analisa o estado da arte da grande reportagem multimídia no jornalismo online, atentando para um momento que se pode definir como “turning point”, ou ponto de virada desse tipo de formato noticioso. A partir de uma sistematização da evolução dos formatos expressivos multimidiáticos da notícia no jornalismo digital, o artigo identifica três momentos principais dessa trajetória: o slide-show noticioso, no início dos anos 2000; os especiais multimídia, de meados de 2000 a 2011 e a gr...

  20. The Turn to Precarity in Twenty-First Century Fiction

    Directory of Open Access Journals (Sweden)

    Morrison Jago

    2014-01-01

    Full Text Available Recent years have seen several attempts by writers and critics to understand the changed sensibility in post-9/11 fiction through a variety of new -isms. This essay explores this cultural shift in a different way, finding a ‘turn to precarity’ in twenty-first century fiction characterised by a renewal of interest in the flow and foreclosure of affect, the resurgence of questions about vulnerability and our relationships to the other, and a heightened awareness of the social dynamics of seeing. The essay draws these tendencies together via the work of Judith Butler in Frames of War, in an analysis of Trezza Azzopardi’s quasi-biographical study of precarious life, Remember Me.