WorldWideScience

Sample records for single time window

  1. Development of windows based software to analyze fluorescence decay with time-correlated single photon counting (TCSPC) setup

    CERN Document Server

    Mallick, M B; Ravindranath, S V G

    2002-01-01

    A VUV spectroscopic facility for studies in photophysics and photochemistry is being set up at INDUS-I synchrotron source, CAT, Indore. For this purpose, a data acquisition system based on time-correlated single photon counting method is being developed for fluorescence lifetime measurement. To estimate fluorescence lifetime from the data collected with this sytem, a Windows based program has been developed using Visual Basic 5.0. It uses instrument response function (IRF) and observed decay curve and estimates parameters of single exponential decay by least square analysis and Marquardt method as convergence mechanism. Estimation of parameters was performed using data collected with a commercial setup. Goodness of fit was judged by evaluating chi R sup 2 , weighted residuals and autocorrelation function. Performance is compared with two commercial software packages and found to be satisfactory.

  2. Single pairing spike-timing dependent plasticity in BiFeO3 memristors with a time window of 25ms to 125µs

    Directory of Open Access Journals (Sweden)

    Nan eDu

    2015-06-01

    Full Text Available Memristive devices are popular among neuromorphic engineers for their ability to emulate forms of spike-driven synaptic plasticity by applying specific voltage and current waveforms at their two terminals. In this paper, we investigate spike-timing dependent plasticity (STDP with a single pairing of one presynaptic voltage spike and one postsynaptic voltage spike in a BiFeO3 memristive device. In most memristive materials the learning window is primarily a function of the material characteristics and not of the applied waveform. In contrast, we show that the analog resistive switching of the developed artificial synapses allows to adjust the learning time constant of the STDP function from 25ms to 125μs via the duration of applied voltage spikes. Also, as the induced weight change may degrade, we investigate the remanence of the resistance change for several hours after analog resistive switching, thus emulating the processes expected in biological synapses. As the power consumption is a major constraint in neuromorphic circuits, we show methods to reduce the consumed energy per setting pulse to only 4.5 pJ in the developed artificial synapses.

  3. Time Modeling: Salvatore Sciarrino, Windows and Beclouding

    Directory of Open Access Journals (Sweden)

    Acácio Tadeu de Camargo Piedade

    2017-08-01

    Full Text Available In this article I intend to discuss one of the figures created by the Italian composer Salvatore Sciarrino: the windowed form. After the composer's explanation of this figure, I argue that windows in composition can open inwards and outwards the musical discourse. On one side, they point to the composition's inner ambiences and constitute an internal remission. On the other, they instigate the audience to comprehend the external reference, thereby constructing intertextuality. After the outward window form, I will consider some techniques of distortion, particularly one that I call beclouding. To conclude, I will comment the question of memory and of compostition as time modeling.

  4. Rumor Detection over Varying Time Windows.

    Science.gov (United States)

    Kwon, Sejeong; Cha, Meeyoung; Jung, Kyomin

    2017-01-01

    This study determines the major difference between rumors and non-rumors and explores rumor classification performance levels over varying time windows-from the first three days to nearly two months. A comprehensive set of user, structural, linguistic, and temporal features was examined and their relative strength was compared from near-complete date of Twitter. Our contribution is at providing deep insight into the cumulative spreading patterns of rumors over time as well as at tracking the precise changes in predictive powers across rumor features. Statistical analysis finds that structural and temporal features distinguish rumors from non-rumors over a long-term window, yet they are not available during the initial propagation phase. In contrast, user and linguistic features are readily available and act as a good indicator during the initial propagation phase. Based on these findings, we suggest a new rumor classification algorithm that achieves competitive accuracy over both short and long time windows. These findings provide new insights for explaining rumor mechanism theories and for identifying features of early rumor detection.

  5. Real time programming environment for Windows

    Energy Technology Data Exchange (ETDEWEB)

    LaBelle, D.R. [LaBelle (Dennis R.), Clifton Park, NY (United States)

    1998-04-01

    This document provides a description of the Real Time Programming Environment (RTProE). RTProE tools allow a programmer to create soft real time projects under general, multi-purpose operating systems. The basic features necessary for real time applications are provided by RTProE, leaving the programmer free to concentrate efforts on his specific project. The current version supports Microsoft Windows{trademark} 95 and NT. The tasks of real time synchronization and communication with other programs are handled by RTProE. RTProE includes a generic method for connecting a graphical user interface (GUI) to allow real time control and interaction with the programmer`s product. Topics covered in this paper include real time performance issues, portability, details of shared memory management, code scheduling, application control, Operating System specific concerns and the use of Computer Aided Software Engineering (CASE) tools. The development of RTProE is an important step in the expansion of the real time programming community. The financial costs associated with using the system are minimal. All source code for RTProE has been made publicly available. Any person with access to a personal computer, Windows 95 or NT, and C or FORTRAN compilers can quickly enter the world of real time modeling and simulation.

  6. Radiation attenuation by single-crystal diamond windows

    Energy Technology Data Exchange (ETDEWEB)

    Guthrie, M.; Pruteanu, C. G.; Donnelly, M. -E.; Molaison, J. J.; dos Santos, A. M.; Loveday, J. S.; Boehler, R.; Tulk, C. A.

    2017-02-01

    As artificial diamond becomes more cost effective it is likely to see increasing use as a window for sample environment equipment used in diffraction experiments. Such windows are particularly useful as they exhibit exceptional mechanical properties in addition to being highly transparent to both X-ray and neutron radiation. A key application is in high-pressure studies, where diamond anvil cells (DACs) are used to access extreme sample conditions. However, despite their utility, an important consideration when using single-crystal diamond windows is their interaction with the incident beam. In particular, the Bragg condition will be satisfied for specific angles and wavelengths, leading to the appearance of diamond Bragg spots on the diffraction detectors but also, unavoidably, to loss of transmitted intensity of the beam that interacts with the sample. This effect can be particularly significant for energy-dispersive measurements, for example, in time-of-flight neutron diffraction work using DACs. This article presents a semi-empirical approach that can be used to correct for this effect, which is a prerequisite for the accurate determination of diffraction intensities.

  7. Quantitative assessment of time trends: influence of time window selection

    International Nuclear Information System (INIS)

    Prosek, A.; Mavko, B.

    2004-01-01

    Quantitative assessment of thermalhydraulic system code predictions is today indispensable for code verification and validation. It is also needed for standard nuclear power plant nodalization development and qualification. Initially the Fast Fourier Transform Based Method (FFTBM) was proposed for accuracy quantification. Later a few new methods were proposed like Automated Code Assessment Program (ACAP) and Stochastic Approximation Ratio Based Method (SARBM). Recently, the review of FFTBM applications was done and reference FFTBM database was proposed consisting of most accurate international standard problems, standard problem exercises or organization calculations as judged by FFTBM. The calculations were presented by primary pressure average amplitude and total accuracy for the whole transient duration. The objective of this study was to investigate how the time window selection influences on the results. For the quantitative assessment various BETHSY experiments and Mochovce plant transient were selected and calculations obtained by RELAP5/MOD3.2 and RELAP5/MOD3.2.2 code, respectively. In the accuracy analysis each transient is subdivided into phases that define the time window and time interval. The time window is time duration of phase. The time interval is time window from the start time of first phase to the end time of selected phase. The analysis was performed for moving time window (sequence of narrow time windows) and increasing time interval (sequence of time intervals). The results for moving time window showed that accuracy measures were very time dependent and they efficiently showed the instantaneous discrepancies occurring in the calculated signal. They also give picture how complex is the transient. The average amplitude (AA) was compared with relative error function (the difference between calculated and measured signal divided by measured signal) and SARBM results. The trends for accuracy measures were similar. These results suggest that for

  8. Single-Sided Natural Ventilation through a Velux Roof Window

    DEFF Research Database (Denmark)

    Li, Zhigang; Nielsen, Peter Vilhelm; Fransson, J.

    2004-01-01

    This paper investigates the single-sided natural ventilation through a VELUX centre pivot roof window under natural weather conditions. The aim of the investigation is to develop an empirical formulation for air flow rate through a roof window based on CFD and tracer gas decay measurement methods....... CFD can separate buoyancy and wind effects in the calculation of the air flow rate through a window opening, but it is difficult to isolate wind effect from buoyancy forces during measurements. The ?Warren-plot? method can be used to separate and analyse the measured data which are dominated by stack...

  9. Market volatility modeling for short time window

    Science.gov (United States)

    de Mattos Neto, Paulo S. G.; Silva, David A.; Ferreira, Tiago A. E.; Cavalcanti, George D. C.

    2011-10-01

    The gain or loss of an investment can be defined by the movement of the market. This movement can be estimated by the difference between the magnitudes of two stock prices in distinct periods and this difference can be used to calculate the volatility of the markets. The volatility characterizes the sensitivity of a market change in the world economy. Traditionally, the probability density function (pdf) of the movement of the markets is analyzed by using power laws. The contributions of this work is two-fold: (i) an analysis of the volatility dynamic of the world market indexes is performed by using a two-year window time data. In this case, the experiments show that the pdf of the volatility is better fitted by exponential function than power laws, in all range of pdf; (ii) after that, we investigate a relationship between the volatility of the markets and the coefficient of the exponential function based on the Maxwell-Boltzmann ideal gas theory. The results show an inverse relationship between the volatility and the coefficient of the exponential function. This information can be used, for example, to predict the future behavior of the markets or to cluster the markets in order to analyze economic patterns.

  10. Reachability cuts for the vehicle routing problem with time windows

    DEFF Research Database (Denmark)

    Lysgaard, Jens

    2004-01-01

    This paper introduces a class of cuts, called reachability cuts, for the Vehicle Routing Problem with Time Windows (VRPTW). Reachability cuts are closely related to cuts derived from precedence constraints in the Asymmetric Traveling Salesman Problem with Time Windows and to k-path cuts...

  11. Windows

    DEFF Research Database (Denmark)

    Heiselberg, Per; Svidt, Kjeld; Nielsen, Peter V.

    In natural ventilation systems fresh air is often provided through opening of windows. However, the knowledge of the performance of windows is rather limited. Computation of natural ventilation air flow through windows is most commonly made using discharge coefficients, that are regarded as being...... constant. The reported results show that the discharge coefficient for a window opening cannot be regarded as a constant and that it varies considerably with the size of the opening area, the window type and the temperature difference. Therefore, the use of a constant value can lead to serious errors...

  12. The vehicle routing problem with time windows and temporal dependencies

    DEFF Research Database (Denmark)

    Dohn, Anders Høeg; Rasmussen, Matias Sevel; Larsen, Jesper

    2011-01-01

    In this article, we formulate the vehicle routing problem with time windows and temporal dependencies. The problem is an extension of the well studied vehicle routing problem with time windows. In addition to the usual constraints, a scheduled time of one visit may restrain the scheduling options...... dependencies are modeled by generalized precedence constraints. Four different master problem formulations are proposed and it is shown that the formulations can be ranked according to the tightness with which they describe the solution space. A tailored time window branching is used to enforce feasibility...

  13. Vehicle Routing Problem with Backhaul, Multiple Trips and Time Window

    Directory of Open Access Journals (Sweden)

    Johan Oscar Ong

    2011-01-01

    Full Text Available Transportation planning is one of the important components to increase efficiency and effectiveness in the supply chain system. Good planning will give a saving in total cost of the supply chain. This paper develops the new VRP variants’, VRP with backhauls, multiple trips, and time window (VRPBMTTW along with its problem solving techniques by using Ant Colony Optimization (ACO and Sequential Insertion as initial solution algorithm. ACO is modified by adding the decoding process in order to determine the number of vehicles, total duration time, and range of duration time regardless of checking capacity constraint and time window. This algorithm is tested by using set of random data and verified as well as analyzed its parameter changing’s. The computational results for hypothetical data with 50% backhaul and mix time windows are reported.

  14. Parallelization of the Vehicle Routing Problem with Time Windows

    DEFF Research Database (Denmark)

    Larsen, Jesper

    1999-01-01

    of customers. In the VRPTW each customer has a time window. Service of a customer must begin within the interval given by the time window. The objective is to minimize some aspect of operating costs (e.g. total distance traveled, number of vehicles needed or a combination of parameters). Since the late 80's......This dissertation presents a number of algorithms for solving the Vehicle Routing Problem with Time Windows (VRPTW). The VRPTW is a generalization of the well known capacity constrained Vehicle Routing Problem (VRP). In the VRP a fleet of vehicles based at a central depot must service a set...... obtained using Lagrange relaxation. This dissertation is divided into three parts. First the theoretical framework is described. Thereafter a number of techniques to improve the performance of the column-generation framework are proposed and analyzed. Finally a parallel algorithm based on the sequential...

  15. Developmental time windows for axon growth influence neuronal network topology.

    Science.gov (United States)

    Lim, Sol; Kaiser, Marcus

    2015-04-01

    Early brain connectivity development consists of multiple stages: birth of neurons, their migration and the subsequent growth of axons and dendrites. Each stage occurs within a certain period of time depending on types of neurons and cortical layers. Forming synapses between neurons either by growing axons starting at similar times for all neurons (much-overlapped time windows) or at different time points (less-overlapped) may affect the topological and spatial properties of neuronal networks. Here, we explore the extreme cases of axon formation during early development, either starting at the same time for all neurons (parallel, i.e., maximally overlapped time windows) or occurring for each neuron separately one neuron after another (serial, i.e., no overlaps in time windows). For both cases, the number of potential and established synapses remained comparable. Topological and spatial properties, however, differed: Neurons that started axon growth early on in serial growth achieved higher out-degrees, higher local efficiency and longer axon lengths while neurons demonstrated more homogeneous connectivity patterns for parallel growth. Second, connection probability decreased more rapidly with distance between neurons for parallel growth than for serial growth. Third, bidirectional connections were more numerous for parallel growth. Finally, we tested our predictions with C. elegans data. Together, this indicates that time windows for axon growth influence the topological and spatial properties of neuronal networks opening up the possibility to a posteriori estimate developmental mechanisms based on network properties of a developed network.

  16. The Electric Traveling Salesman Problem with Time Windows

    DEFF Research Database (Denmark)

    Roberti, Roberto; Wen, Min

    2016-01-01

    To minimize greenhouse gas emissions, the logistic field has seen an increasing usage of electric vehicles. The resulting distribution planning problems present new computational challenges.We address a problem, called Electric Traveling Salesman Problem with Time Windows. We propose a mixed...

  17. A simple metaheuristic for the fleetsize and mix problem with TimeWindows

    NARCIS (Netherlands)

    Bräysy, Olli; Dullaert, Wout; Porkka, Pasi P.

    2018-01-01

    This paper presents a powerful new single-parameter metaheuristic to solve the Fleet Size and Mix Vehicle Routing Problem with Time Windows. The key idea of the new metaheuristic is to perform a random number of random-sized jumps in random order through four well-known local search operators.

  18. Path inequalities for the vehicle routing problem with time windows

    DEFF Research Database (Denmark)

    Kallehauge, Brian; Boland, Natashia; Madsen, Oli B.G.

    2007-01-01

    the advantage of avoiding additional variables and linking constraints. In the new formulation, time windows are modeled using path inequalities that eliminate time and capacity infeasible paths. We present a new class of strengthened path inequalities based on the polyhedral results obtained by Mak (Ph.......D. Thesis, 2001) for a variant of the TSP. We study the VRPTW polytope and determine its dimension. We show that the lifted path inequalities are facet defining under certain assumptions. We also introduce precedence constraints in the context of the VRPTW. Computational experiments are performed...... with a branch and cut algorithm on the Solomon test problems with wide time windows. Based on results on 25-node problems, the outcome is promising compared to leading algorithms in the literature. In particular, we report a solution to a previously unsolved 50-node Solomon test problem R208. The conclusion...

  19. Single-sided natural ventilation through a centre-pivot roof window

    DEFF Research Database (Denmark)

    Iqbal, Ahsan; Nielsen, Peter V.; Gunner, Amalie

    2014-01-01

    The characteristics of centre pivot roof windows for wind driven single-sided ventilation has not been studied before. These types of windows are dominating roof windows in Europe. Knowledge of flow characteristics of this kind of window is essential for accurate designing of natural ventilation...... systems. In this study, numerical methods were used to characterise a centre-pivot roof window for wind-driven single-sided ventilation. A 1:20 scale model house of the Energy Flex House (Denmark) was used in this study. The roof slope was 36o. It was found that the single-sided ventilation through...... the centre-pivot roof window can be characterised by a factor called the flow factor. The flow factor was a function of the sash opening-angle and wind direction. The flow factor increased with increase in opening-angle and decreased with increase in wind direction....

  20. On the vehicle routing problem with time windows

    DEFF Research Database (Denmark)

    Kallehauge, Brian

    2006-01-01

    constrained shortest path subproblems because less negative cycles are introduced and it leads to faster multiplier convergence due to a stabilization of the dual variables. We have embedded the stabilized cutting-plane algorithm in a branch-and-bound search and introduce strong valid inequalities...... inequalities are facet defining under certain assumptions. We also introduce precedence constraints in the context of the VRPTW. Computational experiments are performed with a branch-and-cut algorithm on the Solomon test problems with wide time windows. Based on results on 25-node problems the outcome...... of the exact algorithms proposed in the last three decades for the solution of the vehicle routing problem with time windows. A detailed analysis of the formulations of the VRPTW is presented together with a review of the literature related to the different formulations. We present the two main lines...

  1. Lagged kernel machine regression for identifying time windows of susceptibility to exposures of complex mixtures.

    Science.gov (United States)

    Liu, Shelley H; Bobb, Jennifer F; Lee, Kyu Ha; Gennings, Chris; Claus Henn, Birgit; Bellinger, David; Austin, Christine; Schnaas, Lourdes; Tellez-Rojo, Martha M; Hu, Howard; Wright, Robert O; Arora, Manish; Coull, Brent A

    2017-09-06

    The impact of neurotoxic chemical mixtures on children's health is a critical public health concern. It is well known that during early life, toxic exposures may impact cognitive function during critical time intervals of increased vulnerability, known as windows of susceptibility. Knowledge on time windows of susceptibility can help inform treatment and prevention strategies, as chemical mixtures may affect a developmental process that is operating at a specific life phase. There are several statistical challenges in estimating the health effects of time-varying exposures to multi-pollutant mixtures, such as: multi-collinearity among the exposures both within time points and across time points, and complex exposure-response relationships. To address these concerns, we develop a flexible statistical method, called lagged kernel machine regression (LKMR). LKMR identifies critical exposure windows of chemical mixtures, and accounts for complex non-linear and non-additive effects of the mixture at any given exposure window. Specifically, LKMR estimates how the effects of a mixture of exposures change with the exposure time window using a Bayesian formulation of a grouped, fused lasso penalty within a kernel machine regression (KMR) framework. A simulation study demonstrates the performance of LKMR under realistic exposure-response scenarios, and demonstrates large gains over approaches that consider each time window separately, particularly when serial correlation among the time-varying exposures is high. Furthermore, LKMR demonstrates gains over another approach that inputs all time-specific chemical concentrations together into a single KMR. We apply LKMR to estimate associations between neurodevelopment and metal mixtures in Early Life Exposures in Mexico and Neurotoxicology, a prospective cohort study of child health in Mexico City. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  2. The A-priori Traveling Salesman Problem with Time Windows

    DEFF Research Database (Denmark)

    Larsen, Allan; Madsen, Oli B.G.; Solomon, Marius M.

    2004-01-01

    In this paper we examine the traveling saleman problem with time windows for various degrees of dynamism. In contrast to the static problem, where the dispatcher can plan ahead, in the dynamic version, part or all of the necessary information becomes available only during the day of operation. We...... seek to minimize lateness and examine the impact of this criterion choice on the distance traveled. Our focus on lateness is motivated by the problem faced by overnight mail service providers. We propose a real-time solution method that requires the vehicle, when idle, to wait at the current customer...

  3. Refurbishment of single and double-glazed windows; Sanierung von einfach- und doppeltverglasten Fenstern

    Energy Technology Data Exchange (ETDEWEB)

    Eicher, H.; Erb, M.

    2001-01-15

    This report for the Swiss Federal Office of Energy (SFOE) as part of the research program on the efficient use of energy in buildings takes a look at the refurbishment of single and double-glazed windows. Topics examined include the assessment of window frame condition and the addition of seals as a cost-effective measure. Replacement of the window panes with various single and double glazing as well the installation of such glazing with special coatings is discussed. Further topics examined include the grey energy involved and noise protection aspects.

  4. Resource on-demand reservation based on time-window in optical grid network

    Science.gov (United States)

    Wu, Runze; Ji, Yuefeng

    2007-11-01

    On-demand reservation strategy is proposed for optical network resource scheduling. The proposed approach introduces time window reservation on grid integrated with wavelength-routed optical network, according to the application request with anticipant time range and rate. The time window deploys variable size, when time-window is not suitable for current application requirement, the resource scheduler can negotiate the next time window allocation with the switch. Time-window resource reservation approach loans dividing time multiplexing mechanism. Considering with multiple parallel lightpaths' monopolization, the proposed reservation approach improves network resource request service rate and makes the application having the QoS-aware ability.

  5. Real-time windowing in imaging radar using FPGA technique

    Science.gov (United States)

    Ponomaryov, Volodymyr I.; Escamilla-Hernandez, Enrique

    2005-02-01

    The imaging radar uses the high frequency electromagnetic waves reflected from different objects for estimating of its parameters. Pulse compression is a standard signal processing technique used to minimize the peak transmission power and to maximize SNR, and to get a better resolution. Usually the pulse compression can be achieved using a matched filter. The level of the side-lobes in the imaging radar can be reduced using the special weighting function processing. There are very known different weighting functions: Hamming, Hanning, Blackman, Chebyshev, Blackman-Harris, Kaiser-Bessel, etc., widely used in the signal processing applications. Field Programmable Gate Arrays (FPGAs) offers great benefits like instantaneous implementation, dynamic reconfiguration, design, and field programmability. This reconfiguration makes FPGAs a better solution over custom-made integrated circuits. This work aims at demonstrating a reasonably flexible implementation of FM-linear signal and pulse compression using Matlab, Simulink, and System Generator. Employing FPGA and mentioned software we have proposed the pulse compression design on FPGA using classical and novel windows technique to reduce the side-lobes level. This permits increasing the detection ability of the small or nearly placed targets in imaging radar. The advantage of FPGA that can do parallelism in real time processing permits to realize the proposed algorithms. The paper also presents the experimental results of proposed windowing procedure in the marine radar with such the parameters: signal is linear FM (Chirp); frequency deviation DF is 9.375MHz; the pulse width T is 3.2μs taps number in the matched filter is 800 taps; sampling frequency 253.125*106 MHz. It has been realized the reducing of side-lobes levels in real time permitting better resolution of the small targets.

  6. A window-based time series feature extraction method.

    Science.gov (United States)

    Katircioglu-Öztürk, Deniz; Güvenir, H Altay; Ravens, Ursula; Baykal, Nazife

    2017-10-01

    This study proposes a robust similarity score-based time series feature extraction method that is termed as Window-based Time series Feature ExtraCtion (WTC). Specifically, WTC generates domain-interpretable results and involves significantly low computational complexity thereby rendering itself useful for densely sampled and populated time series datasets. In this study, WTC is applied to a proprietary action potential (AP) time series dataset on human cardiomyocytes and three precordial leads from a publicly available electrocardiogram (ECG) dataset. This is followed by comparing WTC in terms of predictive accuracy and computational complexity with shapelet transform and fast shapelet transform (which constitutes an accelerated variant of the shapelet transform). The results indicate that WTC achieves a slightly higher classification performance with significantly lower execution time when compared to its shapelet-based alternatives. With respect to its interpretable features, WTC has a potential to enable medical experts to explore definitive common trends in novel datasets. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Multi-objective Mobile Robot Scheduling Problem with Dynamic Time Windows

    DEFF Research Database (Denmark)

    Dang, Vinh Quang; Nielsen, Izabela Ewa; Steger-Jensen, Kenn

    2012-01-01

    This paper deals with the problem of scheduling feeding tasks of a single mobile robot which has capability of supplying parts to feeders on pro-duction lines. The performance criterion is to minimize the total traveling time of the robot and the total tardiness of the feeding tasks being scheduled......, simul-taneously. In operation, the feeders have to be replenished a number of times so as to maintain the manufacture of products during a planning horizon. A meth-od based on predefined characteristics of the feeders is presented to generate dynamic time windows of the feeding tasks which are dependent...

  8. Vehicle routing problem with time windows using natural inspired algorithms

    Science.gov (United States)

    Pratiwi, A. B.; Pratama, A.; Sa’diyah, I.; Suprajitno, H.

    2018-03-01

    Process of distribution of goods needs a strategy to make the total cost spent for operational activities minimized. But there are several constrains have to be satisfied which are the capacity of the vehicles and the service time of the customers. This Vehicle Routing Problem with Time Windows (VRPTW) gives complex constrains problem. This paper proposes natural inspired algorithms for dealing with constrains of VRPTW which involves Bat Algorithm and Cat Swarm Optimization. Bat Algorithm is being hybrid with Simulated Annealing, the worst solution of Bat Algorithm is replaced by the solution from Simulated Annealing. Algorithm which is based on behavior of cats, Cat Swarm Optimization, is improved using Crow Search Algorithm to make simplier and faster convergence. From the computational result, these algorithms give good performances in finding the minimized total distance. Higher number of population causes better computational performance. The improved Cat Swarm Optimization with Crow Search gives better performance than the hybridization of Bat Algorithm and Simulated Annealing in dealing with big data.

  9. Improved hybrid information filtering based on limited time window

    Science.gov (United States)

    Song, Wen-Jun; Guo, Qiang; Liu, Jian-Guo

    2014-12-01

    Adopting the entire collecting information of users, the hybrid information filtering of heat conduction and mass diffusion (HHM) (Zhou et al., 2010) was successfully proposed to solve the apparent diversity-accuracy dilemma. Since the recent behaviors are more effective to capture the users' potential interests, we present an improved hybrid information filtering of adopting the partial recent information. We expand the time window to generate a series of training sets, each of which is treated as known information to predict the future links proven by the testing set. The experimental results on one benchmark dataset Netflix indicate that by only using approximately 31% recent rating records, the accuracy could be improved by an average of 4.22% and the diversity could be improved by 13.74%. In addition, the performance on the dataset MovieLens could be preserved by considering approximately 60% recent records. Furthermore, we find that the improved algorithm is effective to solve the cold-start problem. This work could improve the information filtering performance and shorten the computational time.

  10. Single top polarisation as a window to new physics

    Energy Technology Data Exchange (ETDEWEB)

    Aguilar-Saavedra, J.A., E-mail: jaas@ugr.es [Departamento de Física Teórica y del Cosmos, Universidad de Granada, E-18071 Granada (Spain); Degrande, C. [CERN, Theory Department, Geneva 23 CH-1211 (Switzerland); Khatibi, S. [School of Particles and Accelerators, Institute for Research in Fundamental Sciences (IPM), P.O. Box 19395-5531, Tehran (Iran, Islamic Republic of)

    2017-06-10

    We discuss the effect of heavy new physics, parameterised in terms of four-fermion operators, in the polarisation of single top (anti-)quarks in the t-channel process at the LHC. It is found that for operators involving a right-handed top quark field the relative effect on the longitudinal polarisation is twice larger than the relative effect on the total cross section. This enhanced dependence on possible four-fermion contributions makes the polarisation measurements specially interesting, in particular at high momenta.

  11. Experimental analysis of single sided ventilation through a centre pivot roof window

    DEFF Research Database (Denmark)

    Iqbal, Ahsan; Afshari, Alireza; Heiselberg, Per

    2015-01-01

    In the present study bidirectional airflow characteristics of a centre-pivot roof window were analysed in-situ. Both wind and temperature differences were present at the time of measurements. Tracer gas technique using N2O gas was used to estimate the air change rates in the experimental space....... Leakages through the experimental space were estimated using the blower door tests. Air-change rates increased with increase in the window sash opening angle. When the window was open all the way, with an average wind speed of 4 m/s, the average air-change rate was 2. Flow factor was used to characterise...... the bidirectional airflow rates through window. The flow factor of the window increased with increase in the sash opening angle....

  12. Traversing Time and Space from the Blessing Window

    Science.gov (United States)

    Huang, Ya-Ling

    2013-02-01

    The visual graphics for the holographic artwork "Blessing Window" were created from observations of Tainan city, with a focus on the beauty of Chinese characters, their typographic. The concept of movement in the artwork is from a traditional Chinese philosophy, "When the mountain does not move, the road extends, when the road does not extend to the destination, the heart will extend". One multiplex-hologram and an interactive installation were used to combine the visual concepts of typography and the philosophy.

  13. Branch-and-Cut-and-Price for the Pickup and Delivery Problem with Time Windows

    DEFF Research Database (Denmark)

    Røpke, Stefan; Cordeau, Jean-Francois

    2009-01-01

    In the pickup and delivery problem with time windows (PDPTW), vehicle routes must be designed to satisfy a set of transportation requests, each involving a pickup and a delivery location, under capacity, time window, and precedence constraints. This paper introduces a new branch...

  14. A hybrid metaheuristic for the time-dependent vehicle routing problem with hard time windows

    Directory of Open Access Journals (Sweden)

    N. Rincon-Garcia

    2017-01-01

    Full Text Available This article paper presents a hybrid metaheuristic algorithm to solve the time-dependent vehicle routing problem with hard time windows. Time-dependent travel times are influenced by different congestion levels experienced throughout the day. Vehicle scheduling without consideration of congestion might lead to underestimation of travel times and consequently missed deliveries. The algorithm presented in this paper makes use of Large Neighbourhood Search approaches and Variable Neighbourhood Search techniques to guide the search. A first stage is specifically designed to reduce the number of vehicles required in a search space by the reduction of penalties generated by time-window violations with Large Neighbourhood Search procedures. A second stage minimises the travel distance and travel time in an ‘always feasible’ search space. Comparison of results with available test instances shows that the proposed algorithm is capable of obtaining a reduction in the number of vehicles (4.15%, travel distance (10.88% and travel time (12.00% compared to previous implementations in reasonable time.

  15. Two mathematical formulations for the containers drayage problem with time windows

    Directory of Open Access Journals (Sweden)

    Popović, D.

    2012-01-01

    Full Text Available The containers drayage problem studied here arise in ISO container distribution and collecting processes, in regions which are oriented to container sea ports or inland terminals. Containers of different sizes, but mostly 20ft, and 40ft empty and/or loaded should be delivered to, or collected from the customers. Therefore, the problem studied here is closely related to the vehicle routing problem with the time windows that finds an optimal set of or routes visiting deliveries and pickups customers. The specificity of the container drayage problem analyzed here lies in the fact that a truck may simultaneously carry one 40ft, or two 20ft containers, using an appropriate trailer type. This means that in one route two, three or four nodes can be visited, which is equivalent to the problem of matching nodes in single routes which provide a total travel distance shorter than in the case when nodes are visited separately. The paper presents two optimal MIP mathematical formulations for the case when pickup and delivery nodes could be visited only in specific time interals - time windows. Proposed approaches are tested on numerical examples.

  16. Computation of the Short-Time Linear Canonical Transform with Dual Window

    Directory of Open Access Journals (Sweden)

    Lei Huang

    2017-01-01

    Full Text Available The short-time linear canonical transform (STLCT, which maps the time domain signal into the joint time and frequency domain, has recently attracted some attention in the area of signal processing. However, its applications are still limited due to the fact that selection of coefficients of the short-time linear canonical series (STLCS is not unique, because time and frequency elementary functions (together known as basis function of STLCS do not constitute an orthogonal basis. To solve this problem, this paper investigates a dual window solution. First, the nonorthogonal problem that suffered from original window is fulfilled by orthogonal condition with dual window. Then based on the obtained condition, a dual window computation approach of the GT is extended to the STLCS. In addition, simulations verify the validity of the proposed condition and solutions. Furthermore, some possible applied directions are discussed.

  17. A multimodal logistics service network design with time windows and environmental concerns.

    Science.gov (United States)

    Zhang, Dezhi; He, Runzhong; Li, Shuangyan; Wang, Zhongwei

    2017-01-01

    The design of a multimodal logistics service network with customer service time windows and environmental costs is an important and challenging issue. Accordingly, this work established a model to minimize the total cost of multimodal logistics service network design with time windows and environmental concerns. The proposed model incorporates CO2 emission costs to determine the optimal transportation mode combinations and investment selections for transfer nodes, which consider transport cost, transport time, carbon emission, and logistics service time window constraints. Furthermore, genetic and heuristic algorithms are proposed to set up the abovementioned optimal model. A numerical example is provided to validate the model and the abovementioned two algorithms. Then, comparisons of the performance of the two algorithms are provided. Finally, this work investigates the effects of the logistics service time windows and CO2 emission taxes on the optimal solution. Several important management insights are obtained.

  18. A Moving Window Technique in Parallel Finite Element Time Domain Electromagnetic Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Lie-Quan; Candel, Arno; Ng, Cho; Ko, Kwok; /SLAC

    2010-06-07

    A moving window technique for the finite element time domain (FETD) method is developed to simulate the propagation of electromagnetic waves induced by the transit of a charged particle beam inside large and long structures. The window moving along with the beam in the computational domain adopts high-order finite-element basis functions through p refinement and/or a high-resolution mesh through h refinement so that a sufficient accuracy is attained with substantially reduced computational costs. Algorithms to transfer discretized fields from one mesh to another, which are the key to implementing a moving window in a finite-element unstructured mesh, are presented. Numerical experiments are carried out using the moving window technique to compute short-range wakefields in long accelerator structures. The results are compared with those obtained from the normal FETD method and the advantages of using the moving window technique are discussed.

  19. Iterated local search algorithm for solving the orienteering problem with soft time windows.

    Science.gov (United States)

    Aghezzaf, Brahim; Fahim, Hassan El

    2016-01-01

    In this paper we study the orienteering problem with time windows (OPTW) and the impact of relaxing the time windows on the profit collected by the vehicle. The way of relaxing time windows adopted in the orienteering problem with soft time windows (OPSTW) that we study in this research is a late service relaxation that allows linearly penalized late services to customers. We solve this problem heuristically by considering a hybrid iterated local search. The results of the computational study show that the proposed approach is able to achieve promising solutions on the OPTW test instances available in the literature, one new best solution is found. On the newly generated test instances of the OPSTW, the results show that the profit collected by the OPSTW is better than the profit collected by the OPTW.

  20. Dynamic Allan Variance Analysis Method with Time-Variant Window Length Based on Fuzzy Control

    Directory of Open Access Journals (Sweden)

    Shanshan Gu

    2015-01-01

    Full Text Available To solve the problem that dynamic Allan variance (DAVAR with fixed length of window cannot meet the identification accuracy requirement of fiber optic gyro (FOG signal over all time domains, a dynamic Allan variance analysis method with time-variant window length based on fuzzy control is proposed. According to the characteristic of FOG signal, a fuzzy controller with the inputs of the first and second derivatives of FOG signal is designed to estimate the window length of the DAVAR. Then the Allan variances of the signals during the time-variant window are simulated to obtain the DAVAR of the FOG signal to describe the dynamic characteristic of the time-varying FOG signal. Additionally, a performance evaluation index of the algorithm based on radar chart is proposed. Experiment results show that, compared with different fixed window lengths DAVAR methods, the change of FOG signal with time can be identified effectively and the evaluation index of performance can be enhanced by 30% at least by the DAVAR method with time-variant window length based on fuzzy control.

  1. Location-routing Problem with Fuzzy time windows and Traffic time

    Directory of Open Access Journals (Sweden)

    Shima Teimoori

    2014-05-01

    Full Text Available The location-routing problem is a relatively new branch of logistics system. Its objective is to determine a suitable location for constructing distribution warehouses and proper transportation routing from warehouse to the customer. In this study, the location-routing problem is investigated with considering fuzzy servicing time window for each customer. Another important issue in this regard is the existence of congested times during the service time and distributing goods to the customer. This caused a delay in providing service for customer and imposed additional costs to distribution system. Thus we have provided a mathematical model for designing optimal distributing system. Since the vehicle location-routing problem is Np-hard, thus a solution method using genetic meta-heuristic algorithm was developed and the optimal sequence of servicing for the vehicle and optimal location for the warehouses were determined through an example.

  2. Fully automatic time-window selection using machine learning for global adjoint tomography

    Science.gov (United States)

    Chen, Y.; Hill, J.; Lei, W.; Lefebvre, M. P.; Bozdag, E.; Komatitsch, D.; Tromp, J.

    2017-12-01

    Selecting time windows from seismograms such that the synthetic measurements (from simulations) and measured observations are sufficiently close is indispensable in a global adjoint tomography framework. The increasing amount of seismic data collected everyday around the world demands "intelligent" algorithms for seismic window selection. While the traditional FLEXWIN algorithm can be "automatic" to some extent, it still requires both human input and human knowledge or experience, and thus is not deemed to be fully automatic. The goal of intelligent window selection is to automatically select windows based on a learnt engine that is built upon a huge number of existing windows generated through the adjoint tomography project. We have formulated the automatic window selection problem as a classification problem. All possible misfit calculation windows are classified as either usable or unusable. Given a large number of windows with a known selection mode (select or not select), we train a neural network to predict the selection mode of an arbitrary input window. Currently, the five features we extract from the windows are its cross-correlation value, cross-correlation time lag, amplitude ratio between observed and synthetic data, window length, and minimum STA/LTA value. More features can be included in the future. We use these features to characterize each window for training a multilayer perceptron neural network (MPNN). Training the MPNN is equivalent to solve a non-linear optimization problem. We use backward propagation to derive the gradient of the loss function with respect to the weighting matrices and bias vectors and use the mini-batch stochastic gradient method to iteratively optimize the MPNN. Numerical tests show that with a careful selection of the training data and a sufficient amount of training data, we are able to train a robust neural network that is capable of detecting the waveforms in an arbitrary earthquake data with negligible detection error

  3. Optimal time window for measurement of renal output parameters.

    Science.gov (United States)

    Kuyvenhoven, Jacob D; Ham, Hamphrey R; Piepsz, Amy

    2002-01-01

    Although normalised residual activity (NORA) and output efficiency (OE) are usually measured at a fixed time t, their dependency on t may affect the prediction of mean transit time (MTT). This study aimed to evaluate their degree of dependency on t and to determine an optimal time of measurement by assessment of their relationship with MTT for various times t. A simulation model generated 232 cortical renograms by convolving one plasma disappearance curve with 232 created cortical retention functions. The results show that considerable changes are observed for NORA and OE, depending on the time of measurement t. The choice of this time significantly influences the predictive value of these parameters for estimating MTT. The optimal time for measurement of NORA and OE should be close to the MTT, at the moment when emptying takes place. In the clinical practice, it should be adapted to the clinical problem under investigation.

  4. Residual Motion and Duty Time in Respiratory Gating Radiotherapy Using Individualized or Population-Based Windows

    International Nuclear Information System (INIS)

    Fuji, Hiroshi; Asada, Yoshihiro; Numano, Masumi; Yamashita, Haruo; Nishimura, Tetsuo; Hashimoto, Takayuki; Harada, Hideyuki; Asakura, Hirofumi; Murayama, Shigeyuki

    2009-01-01

    Purpose: The efficiency and precision of respiratory gated radiation therapy for tumors is affected by variations in respiration-induced tumor motion. We evaluated the use of individualized and population-based parameters for such treatment. Methods and Materials: External respiratory signal records and images of respiration-induced tumor motion were obtained from 42 patients undergoing respiratory gated radiation therapy for liver tumors. Gating window widths were calculated for each patient, with 2, 4, and 10 mm of residual motion, and the mean was defined as the population-based window width. Residual motions based on population-based and predefined window widths were compared. Duty times based on whole treatment sessions, at various window levels, were calculated. The window level giving the longest duty time was defined as the individualized most efficient level (MEL). MELs were also calculated based on the first 10 breathing cycles. The duty times for population-based MELs (defined as mean MELs) and individualized MELs were compared. Results: Tracks of respiration-induced tumor motion ranged from 3 to 50 mm. Half of the patients had larger actual residual motions than the assigned residual motions. Duty times were greater when based on individualized, rather than population-based, window widths. The MELs established during whole treatment sessions for 2 mm and 4 mm of residual motion gave significantly increased duty times, whereas those calculated using the first 10 breathing cycles showed only marginal increases. Conclusions: Using individualized window widths and levels provided more precise and efficient respiratory gated radiation therapy. However, methods for predicting individualized window levels before treatment remain to be explored.

  5. Seismic signal time-frequency analysis based on multi-directional window using greedy strategy

    Science.gov (United States)

    Chen, Yingpin; Peng, Zhenming; Cheng, Zhuyuan; Tian, Lin

    2017-08-01

    Wigner-Ville distribution (WVD) is an important time-frequency analysis technology with a high energy distribution in seismic signal processing. However, it is interfered by many cross terms. To suppress the cross terms of the WVD and keep the concentration of its high energy distribution, an adaptive multi-directional filtering window in the ambiguity domain is proposed. This begins with the relationship of the Cohen distribution and the Gabor transform combining the greedy strategy and the rotational invariance property of the fractional Fourier transform in order to propose the multi-directional window, which extends the one-dimensional, one directional, optimal window function of the optimal fractional Gabor transform (OFrGT) to a two-dimensional, multi-directional window in the ambiguity domain. In this way, the multi-directional window matches the main auto terms of the WVD more precisely. Using the greedy strategy, the proposed window takes into account the optimal and other suboptimal directions, which also solves the problem of the OFrGT, called the local concentration phenomenon, when encountering a multi-component signal. Experiments on different types of both the signal models and the real seismic signals reveal that the proposed window can overcome the drawbacks of the WVD and the OFrGT mentioned above. Finally, the proposed method is applied to a seismic signal's spectral decomposition. The results show that the proposed method can explore the space distribution of a reservoir more precisely.

  6. Evaluating scaled windowed variance methods for estimating the Hurst coefficient of time series

    OpenAIRE

    Cannon, Michael J.; Percival, Donald B.; Caccia, David C.; Raymond, Gary M.; Bassingthwaighte, James B.

    1997-01-01

    Three-scaled windowed variance methods (standard, linear regression detrended, and brdge detrended) for estimating the Hurst coefficient (H) are evaluated. The Hurst coefficient, with 0 < H < 1, characterizes self-similar decay in the time-series autocorrelation function. The scaled windowed variance methods estimate H for fractional Brownian motion (fBm) signals which are cumulative sums of fractional Gaussian noise (fGn) signals. For all three methods both the bias and standard deviation of...

  7. A Nonadaptive Window-Based PLL for Single-Phase Applications

    DEFF Research Database (Denmark)

    Golestan, Saeed; Guerrero, Josep M.; Quintero, Juan Carlos Vasquez

    2018-01-01

    The rectangular window filter, typically known as the moving average filter (MAF), is a quasi-ideal low-pass filter that has found wide application in designing advanced single-phase phase-locked loops (PLLs). Most often, the MAF is employed as an in-loop filter within the control loop of the sin......The rectangular window filter, typically known as the moving average filter (MAF), is a quasi-ideal low-pass filter that has found wide application in designing advanced single-phase phase-locked loops (PLLs). Most often, the MAF is employed as an in-loop filter within the control loop...... response is avoided. Nevertheless, the PLL implementation complexity considerably increases as MAFs are frequency-adaptive and, therefore, they require an additional frequency detector for estimating the grid frequency. To reduce the implementation complexity while maintaining a good performance, using...... a nonadaptive MAF-based QSG with some error compensators is suggested in this letter. The effectiveness of the resultant PLL, which is briefly called the nonadaptive MAF-based PLL, is verified using experimental results....

  8. A Fast Evolutionary Metaheuristic for VRP with Time Windows

    NARCIS (Netherlands)

    Bräysy, Olli; Dullaert, Wout

    2003-01-01

    This paper presents a new evolutionary metaheuristic for the vehicle routing problem with time windiows. Ideas on multi-start local search, ejection chains, simulated annealing and evolutionary computation are combined in a heuristic that is both robust and efficient. the proposed method produces

  9. Refinements of the column generation process for the Vehicle Routing Problem with Time Windows

    DEFF Research Database (Denmark)

    Larsen, Jesper

    2004-01-01

    interval denoted the time window. The objective is to determine routes for the vehicles that minimizes the accumulated cost (or distance) with respect to the above mentioned constraints. Currently the best approaches for determining optimal solutions are based on column generation and Branch......-and-Bound, also known as Branch-and-Price. This paper presents two ideas for run-time improvements of the Branch-and-Price framework for the Vehicle Routing Problem with Time Windows. Both ideas reveal a significant potential for using run-time refinements when speeding up an exact approach without compromising...

  10. The Vehicle Routing Problem with Time Windows and Temporal Dependencies

    DEFF Research Database (Denmark)

    Rasmussen, Matias Sevel; Dohn, Anders Høeg; Larsen, Jesper

    on minimum or maximum gaps between visits. There is a vast amount of literature on VRPTW and its variants. VRPTW is known to be NP-hard, nevertheless exact solution of the problem has received a lot of attention. The most successful approach is based on a Dantzig-Wolfe decomposition of the mathematical model...... to arrive at high-quality feasible solutions. A problem from the Port of Singapore, where technicians are allocated to service jobs has previously been studied. For each job, a certain combination of technicians with individual skills is needed. The technicians must be present at the same time, and hence...

  11. Effect of the time window on the heat-conduction information filtering model

    Science.gov (United States)

    Guo, Qiang; Song, Wen-Jun; Hou, Lei; Zhang, Yi-Lu; Liu, Jian-Guo

    2014-05-01

    Recommendation systems have been proposed to filter out the potential tastes and preferences of the normal users online, however, the physics of the time window effect on the performance is missing, which is critical for saving the memory and decreasing the computation complexity. In this paper, by gradually expanding the time window, we investigate the impact of the time window on the heat-conduction information filtering model with ten similarity measures. The experimental results on the benchmark dataset Netflix indicate that by only using approximately 11.11% recent rating records, the accuracy could be improved by an average of 33.16% and the diversity could be improved by 30.62%. In addition, the recommendation performance on the dataset MovieLens could be preserved by only considering approximately 10.91% recent records. Under the circumstance of improving the recommendation performance, our discoveries possess significant practical value by largely reducing the computational time and shortening the data storage space.

  12. Optimizing Time Windows For Managing Export Container Arrivals At Chinese Container Terminals

    DEFF Research Database (Denmark)

    Chen, Gang; Yang, Zhongzhen

    2010-01-01

    Management of truck transport in a port area is important for Chinese container ports as heavy traffic congestion not only limits the terminal capacity but also generates serious air pollution. This paper explores an effective way to manage the truck traffic of export containers based on a time...... and the length of each time window. Finally, the model and the heuristic are tested using real data from a Chinese container terminal, and the result indicates that optimization of the time window can effectively flatten the peak traffic of export container trucks - one of the primary causes of road traffic...

  13. The Linehaul-Feeder Vehicle Routing Problem with Virtual Depots and Time Windows

    Directory of Open Access Journals (Sweden)

    Huey-Kuo Chen

    2011-01-01

    Full Text Available This paper addresses the linehaul-feeder vehicle routing problem with virtual depots and time windows (LFVRPTW. Small and large vehicles deliver services to customers within time constraints; small vehicles en route may reload commodities from either the physical depot or from the larger vehicle at a virtual depot before continuing onward. A two-stage solution heuristic involving Tabu search is proposed to solve this problem. The test results show that the LFVRPTW performs better than the vehicle routing problem with time windows in terms of both objective value and the number of small vehicles dispatched.

  14. Opening a New Time Window for Treatment of Stroke by Targeting HDAC2.

    Science.gov (United States)

    Lin, Yu-Hui; Dong, Jian; Tang, Ying; Ni, Huan-Yu; Zhang, Yu; Su, Ping; Liang, Hai-Ying; Yao, Meng-Cheng; Yuan, Hong-Jin; Wang, Dong-Liang; Chang, Lei; Wu, Hai-Yin; Luo, Chun-Xia; Zhu, Dong-Ya

    2017-07-12

    Narrow therapeutic window limits treatments with thrombolysis and neuroprotection for most stroke patients. Widening therapeutic window remains a critical challenge. Understanding the key mechanisms underlying the pathophysiological events in the peri-infarct area where secondary injury coexists with neuroplasticity over days to weeks may offer an opportunity for expanding the therapeutic window. Here we show that ischemia-induced histone deacetylase 2 (HDAC2) upregulation from 5 to 7 d after stroke plays a crucial role. In this window phase, suppressing HDAC2 in the peri-infarct cortex of rodents by HDAC inhibitors, knockdown or knock-out of Hdac2 promoted recovery of motor function from stroke via epigenetically enhancing cells survival and neuroplasticity of surviving neurons as well as reducing neuroinflammation, whereas overexpressing HDAC2 worsened stroke-induced functional impairment of both WT and Hdac2 conditional knock-out mice. More importantly, inhibiting other isoforms of HDACs had no effect. Thus, the intervention by precisely targeting HDAC2 in this window phase is a novel strategy for the functional recovery of stroke survivors. SIGNIFICANCE STATEMENT Narrow time window phase impedes current therapies for stroke patients. Understanding the key mechanisms underlying secondary injury may open a new window for pharmacological interventions to promote recovery from stroke. Our study indicates that ischemia-induced histone deacetylase 2 upregulation from 5 to 7 d after stroke mediates the secondary functional loss by reducing survival and neuroplasticity of peri-infarct neurons as well as augmenting neuroinflammation. Thus, precisely targeting histone deacetylase 2 in the window phase provides a novel therapeutic strategy for stroke recovery. Copyright © 2017 the authors 0270-6474/17/376712-17$15.00/0.

  15. Reducing Marine Container Terminal Gate Congestion with Vessel-Dependent Time Windows For Truck Entries

    DEFF Research Database (Denmark)

    Chen, Gang; Yang, Zhongzhen; Jiang, Liping

    In recent years, marine container terminal gate congestion has become a serious issue, because it not only limits the efficiency of the logistics system but also generates serious air pollution. The direct reason has been recognized to be the unmanaged container truck arrivals. One of the possible...... solutions is that the terminal operator provides vessel-dependent time windows for the truck entries, which has already been used in many Chinese seaports. Previously, the authors proposed the idea of time window optimization and analyzed its economic feasibility in the context of the export direction gate...... operation. This paper, as a following study, addresses the practical application of this solution. First, a framework is developed for the application of time window optimization in container terminals. Based on the framework, the optimization model is modified with more practical constraints...

  16. WinGraphics: An optimized windowing environment for interactive real-time simulations

    International Nuclear Information System (INIS)

    Verboncoeur, J.P.; Vahedi, V.

    1989-01-01

    We have developed a customized windowing environment, Win Graphics, which provides particle simulation codes with an interactive user interface. The environment supports real-time animation of the simulation, displaying multiple diagnostics as they evolve in time. In addition, keyboard and printer (PostScript and dot matrix) support is provided. This paper describes this environment

  17. A Threshold Accepting Metaheuristic for the Vehicle Routing Problem with Time Windows

    NARCIS (Netherlands)

    Bräysy, Olli; Berger, Jean; Barkaoui, Mohamed; Dullaert, Wout

    2003-01-01

    Threshold Accepting, a variant of Simulated Annealing, is applied for the first time to a set of 356 benchmark instances for the Vehicle Routing with Time Windows. The Threshold Accepting metaheuristic is used to improve upon results obtained with a recent parallel genetic algorithm and a

  18. A Threshold Accepting Metaheuristic for the Vehicle Routing Problem with Time Windows.

    NARCIS (Netherlands)

    Bräysy, Olli; Berger, Jean; Barkaoui, Mohamed; Dullaert, Wout

    2003-01-01

    Threshold Accepting, a variant of Simulated, Annealing, is applied for the first time to a set of 356 benchmark instances for the Vehicle Routing with Time Windows. The Threshold Accepting metaheuristic is used to improve upon results obtained with a recent parallel genetic algorithm and a

  19. Optimizing Time Windows For Managing Export Container Arrivals At Chinese Container Terminals

    DEFF Research Database (Denmark)

    Chen, Gang; Yang, Zhongzhen

    2010-01-01

    window management programme that is widely used in Chinese terminals to facilitate terminal and truck delivery operations. Firstly, the arrangement of time windows is assumed to follow the principle of minimizing transport costs. A cost function is defined that includes the costs of truck and driver......Management of truck transport in a port area is important for Chinese container ports as heavy traffic congestion not only limits the terminal capacity but also generates serious air pollution. This paper explores an effective way to manage the truck traffic of export containers based on a time...

  20. Efficient Constraint Handling in Electromagnetism-Like Algorithm for Traveling Salesman Problem with Time Windows

    Directory of Open Access Journals (Sweden)

    Alkın Yurtkuran

    2014-01-01

    Full Text Available The traveling salesman problem with time windows (TSPTW is a variant of the traveling salesman problem in which each customer should be visited within a given time window. In this paper, we propose an electromagnetism-like algorithm (EMA that uses a new constraint handling technique to minimize the travel cost in TSPTW problems. The EMA utilizes the attraction-repulsion mechanism between charged particles in a multidimensional space for global optimization. This paper investigates the problem-specific constraint handling capability of the EMA framework using a new variable bounding strategy, in which real-coded particle’s boundary constraints associated with the corresponding time windows of customers, is introduced and combined with the penalty approach to eliminate infeasibilities regarding time window violations. The performance of the proposed algorithm and the effectiveness of the constraint handling technique have been studied extensively, comparing it to that of state-of-the-art metaheuristics using several sets of benchmark problems reported in the literature. The results of the numerical experiments show that the EMA generates feasible and near-optimal results within shorter computational times compared to the test algorithms.

  1. Efficient Constraint Handling in Electromagnetism-Like Algorithm for Traveling Salesman Problem with Time Windows

    Science.gov (United States)

    Yurtkuran, Alkın

    2014-01-01

    The traveling salesman problem with time windows (TSPTW) is a variant of the traveling salesman problem in which each customer should be visited within a given time window. In this paper, we propose an electromagnetism-like algorithm (EMA) that uses a new constraint handling technique to minimize the travel cost in TSPTW problems. The EMA utilizes the attraction-repulsion mechanism between charged particles in a multidimensional space for global optimization. This paper investigates the problem-specific constraint handling capability of the EMA framework using a new variable bounding strategy, in which real-coded particle's boundary constraints associated with the corresponding time windows of customers, is introduced and combined with the penalty approach to eliminate infeasibilities regarding time window violations. The performance of the proposed algorithm and the effectiveness of the constraint handling technique have been studied extensively, comparing it to that of state-of-the-art metaheuristics using several sets of benchmark problems reported in the literature. The results of the numerical experiments show that the EMA generates feasible and near-optimal results within shorter computational times compared to the test algorithms. PMID:24723834

  2. Efficient constraint handling in electromagnetism-like algorithm for traveling salesman problem with time windows.

    Science.gov (United States)

    Yurtkuran, Alkın; Emel, Erdal

    2014-01-01

    The traveling salesman problem with time windows (TSPTW) is a variant of the traveling salesman problem in which each customer should be visited within a given time window. In this paper, we propose an electromagnetism-like algorithm (EMA) that uses a new constraint handling technique to minimize the travel cost in TSPTW problems. The EMA utilizes the attraction-repulsion mechanism between charged particles in a multidimensional space for global optimization. This paper investigates the problem-specific constraint handling capability of the EMA framework using a new variable bounding strategy, in which real-coded particle's boundary constraints associated with the corresponding time windows of customers, is introduced and combined with the penalty approach to eliminate infeasibilities regarding time window violations. The performance of the proposed algorithm and the effectiveness of the constraint handling technique have been studied extensively, comparing it to that of state-of-the-art metaheuristics using several sets of benchmark problems reported in the literature. The results of the numerical experiments show that the EMA generates feasible and near-optimal results within shorter computational times compared to the test algorithms.

  3. New design for photonic temporal integration with combined high processing speed and long operation time window.

    Science.gov (United States)

    Asghari, Mohammad H; Park, Yongwoo; Azaña, José

    2011-01-17

    We propose and experimentally prove a novel design for implementing photonic temporal integrators simultaneously offering a high processing bandwidth and a long operation time window, namely a large time-bandwidth product. The proposed scheme is based on concatenating in series a time-limited ultrafast photonic temporal integrator, e.g. implemented using a fiber Bragg grating (FBG), with a discrete-time (bandwidth limited) optical integrator, e.g. implemented using an optical resonant cavity. This design combines the advantages of these two previously demonstrated photonic integrator solutions, providing a processing speed as high as that of the time-limited ultrafast integrator and an operation time window fixed by the discrete-time integrator. Proof-of-concept experiments are reported using a uniform fiber Bragg grating (as the original time-limited integrator) connected in series with a bulk-optics coherent interferometers' system (as a passive 4-points discrete-time photonic temporal integrator). Using this setup, we demonstrate accurate temporal integration of complex-field optical signals with time-features as fast as ~6 ps, only limited by the processing bandwidth of the FBG integrator, over time durations as long as ~200 ps, which represents a 4-fold improvement over the operation time window (~50 ps) of the original FBG integrator.

  4. Formulations and exact algorithms for the vehicle routing problem with time windows

    DEFF Research Database (Denmark)

    Kallehauge, Brian

    2008-01-01

    In this paper we review the exact algorithms proposed in the last three decades for the solution of the vehicle routing problem with time windows (VRPTW). The exact algorithms for the VRPTW are in many aspects inherited from work on the traveling salesman problem (TSP). In recognition of this fact...

  5. A penalty-based edge assembly memetic algorithm for the vehicle routing problem with time windows

    NARCIS (Netherlands)

    Nagata, Yuichi; Bräysy, Olli; Dullaert, Wout

    In this paper, we present an effective memetic algorithm for the vehicle routing problem with time windows (VRPTW). The paper builds upon an existing edge assembly crossover (EAX) developed for the capacitated VRP. The adjustments of the EAX operator and the introduction of a novel penalty function

  6. Lagrangean Duality Applied on Vehicle Routing with Time Windows - Experimental Results

    DEFF Research Database (Denmark)

    Kallehauge, Brian; Larsen, Jesper; Madsen, Oli B.G.

    2001-01-01

    This report presents the results of the application of a non-differentiable optimization method in connection with the Vehicle Routing Problem with Time Windows (VRPTW). The VRPTW is an extension of the Vehicle Routing Problem. In the VRPTW the service at each customer must start within an associ...

  7. A Fast Evolutionary Metaheuristic for the Vehicle Routing Problem with Time Windows

    NARCIS (Netherlands)

    Bräysy, Olli; Dullaert, W.

    2003-01-01

    This paper presents a new evolutionary metaheuristic for the vehicle routing problem with time windows. Ideas on multi-start local search, ejection chains, simulated annealing and evolutionary computation are combined in a heuristic that is both robust and efficient. The proposed method produces

  8. Controlled time of arrival windows for already initiated energy-neutral continuous descent operations

    OpenAIRE

    Dalmau Codina, Ramon; Prats Menéndez, Xavier

    2017-01-01

    Continuous descent operations with controlled times of arrival at one or several metering fixes could enable environmentally friendly procedures without compromising terminal airspace capacity. This paper focuses on controlled time of arrival updates once the descent has been already initiated, assessing the feasible time window (and associated fuel consumption) of continuous descent operations requiring neither thrust nor speed-brake usage along the whole descent (i.e. only elevator control ...

  9. Optical access network using centralized light source, single-mode fiber + broad wavelength window multimode fiber

    Science.gov (United States)

    Yam, Scott S.-H.; Kim, Jaedon; Gutierrez, David; Achten, Frank

    2006-08-01

    Access networks based on a single-mode fiber (SMF) using a centralized light source (CLS) have attracted much attention recently due to their wavelength management flexibility and potential for cost reduction at customers' premises. Future networks, in addition, are likely to contain segments of multimode fiber (MMF), whose core dimension is relatively large in comparison with its single-mode counterpart, substantially reducing fiber alignment constraints and the subsequent network construction and installation cost. In this study, a CLS-based passive optical network (PON) is proposed, which will use a new generation of high-performance MMF optimized for a broad wavelength transmission window spanning from 1300to1550 nm, with a bandwidth distance product (BDP) of 40 Gbit/s-km. The proposed architecture is implemented in a test bed, and its performance is verified by bit error ratio (BER) measurement. Results show that we can implement high-performance CLS-based PONs containing both an SMF and an MMF infrastructure, simultaneously.

  10. Calculation of retention time tolerance windows with absolute confidence from shared liquid chromatographic retention data.

    Science.gov (United States)

    Boswell, Paul G; Abate-Pella, Daniel; Hewitt, Joshua T

    2015-09-18

    Compound identification by liquid chromatography-mass spectrometry (LC-MS) is a tedious process, mainly because authentic standards must be run on a user's system to be able to confidently reject a potential identity from its retention time and mass spectral properties. Instead, it would be preferable to use shared retention time/index data to narrow down the identity, but shared data cannot be used to reject candidates with an absolute level of confidence because the data are strongly affected by differences between HPLC systems and experimental conditions. However, a technique called "retention projection" was recently shown to account for many of the differences. In this manuscript, we discuss an approach to calculate appropriate retention time tolerance windows for projected retention times, potentially making it possible to exclude candidates with an absolute level of confidence, without needing to have authentic standards of each candidate on hand. In a range of multi-segment gradients and flow rates run among seven different labs, the new approach calculated tolerance windows that were significantly more appropriate for each retention projection than global tolerance windows calculated for retention projections or linear retention indices. Though there were still some small differences between the labs that evidently were not taken into account, the calculated tolerance windows only needed to be relaxed by 50% to make them appropriate for all labs. Even then, 42% of the tolerance windows calculated in this study without standards were narrower than those required by WADA for positive identification, where standards must be run contemporaneously. Copyright © 2015 Elsevier B.V. All rights reserved.

  11. Windowing of THz time-domain spectroscopy signals: A study based on lactose

    Science.gov (United States)

    Vázquez-Cabo, José; Chamorro-Posada, Pedro; Fraile-Peláez, Francisco Javier; Rubiños-López, Óscar; López-Santos, José María; Martín-Ramos, Pablo

    2016-05-01

    Time-domain spectroscopy has established itself as a reference method for determining material parameters in the terahertz spectral range. This procedure requires the processing of the measured time-domain signals in order to estimate the spectral data. In this work, we present a thorough study of the properties of the signal windowing, a step previous to the parameter extraction algorithm, that permits to improve the accuracy of the results. Lactose has been used as sample material in the study.

  12. Mutual Information-Based Planning for Informative Windowed Forecasting of Continuous-Time Linear Systems

    OpenAIRE

    Choi, Han-Lim

    2013-01-01

    This paper presents expression of mutual information that defines the information gain in planning of sensing resources, when the goal is to reduce the forecast uncertainty of some quantities of interest and the system dynamics is described as a continuous-time linear system. The method extends the smoother approach in [5] to handle more general notion of verification entity - continuous sequence of variables over some finite time window in the future. The expression of mutual information for...

  13. GA microwave window development

    International Nuclear Information System (INIS)

    Moeller, C.P.; Kasugai, A.; Sakamoto, K.; Takahashi, K.

    1994-10-01

    The GA prototype distributed window was tested in a 32 mm diam. waveguide system at a power density suitable for a MW gyrotron, using the JAERI/Toshiba 110 GHz long pulse internal converter gyrotron in the JAERI test stand. The presence of the untilted distributed window had no adverse effect on the gyrotron operation. A pulse length of 10 times the calculated thermal equilibrium time (1/e time) of 30 msec was reached, and the window passed at least 750 pulses greater than 30 msec and 343 pulses greater than 60 msec. Beyond 100 msec, the window calorimetry reached steady state, allowing the window dissipation to be measured in a single pulse. The measured loss of 4.0% agrees both with the estimated loss, on which the stress calculations are based, and with the attenuation measured at low power in the HE 11 mode. After the end of the tests, the window was examined; no evidence of arcing air coating was found in the part of the window directly illuminated by the microwaves, although there was discoloration in a recess containing an optical diagnostic which outgassed, causing a local discharge to occur in that recess. Finally, there was no failure of the metal-sapphire joints during a total operating time of 50 seconds consisting of pulses longer than 30 msec

  14. INTRODUCING ELECTRONIC MARITIME SINGLE WINDOW BY PORT COMMUNITIES IN THE ADRIATIC REGION

    Directory of Open Access Journals (Sweden)

    Bojan BEŠKOVNIK

    2015-12-01

    Full Text Available The article analysis specific fields of procedures for ship arrival and acceptance in the port, that are predefined by the Directive 2010/65/EU. The directive poses the framework for the Maritime Single Window (MSW development in EU. The article brings original and scientific contribution, as it presents the model for Slovenian MSW (SI MSW. The model covers the need of different groups of stakeholder from the local port community. The proposed MSW architecture unifies communication channels and reduces interfaces in business to port (B2P and business to administration (B2A operational processes for ship formalities. Consequently, the business to customer (B2C relationship benefits from lean operation procedures. The focus is also on information exchange standardization. The paper presents principal benefits of the model implementation in the Slovenian port community. The SI MSW model might be adopted also in other port communities in the Adriatic region or to be used as the main platform for further local improvement.

  15. Applying Particle Swarm Optimization for Solving Team Orienteering Problem with Time Windows

    Directory of Open Access Journals (Sweden)

    The Jin Ai

    2014-01-01

    Full Text Available The Team Orienteering Problem With Time Windows (TOPTW is a transportation problem case that have a set of vertices with a score, service time, and the time windows, start and final at a depot location. A number of paths are constructed to maximize the total collected score by the vertices which is visited. Each vertice can be visited only once and the visit can only start during the  time window of vertices. This paper proposes a Particle Swarm Optimization algorithm for solving the TOPTW, by defining a specific particle for representing the solution of TOPTW within the PSO algorithm and two alternatives, called PSO_TOPTW1 and PSO_TOPTW2, for translating the particle position to form the routes of the path. The performance of the proposed PSO algorithm is evaluated through some benchmark data problem available in the literature. The computational results show that the proposed PSO is able to produce sufficiently good TOPTW solutions that are comparable with corresponding solutions from other existing methods for solving the TOPTW.

  16. An effective multirestart deterministic annealing metaheuristic for the fleet size and mix vehicle-routing problem with time windows

    NARCIS (Netherlands)

    Bräysy, Olli; Dullaert, Wout; Hasle, Geir; Mester, David; Gendreau, Michel

    This paper presents a new deterministic annealing metaheuristic for the fleet size and mix vehicle-routing problem with time windows. The objective is to service, at minimal total cost, a set of customers within their time windows by a heterogeneous capacitated vehicle fleet. First, we motivate and

  17. Multiple Charging Station Location-Routing Problem with Time Window of Electric Vehicle

    Directory of Open Access Journals (Sweden)

    Wang Li-ying

    2015-11-01

    Full Text Available This paper presents the electric vehicle (EV multiple charging station location-routing problem with time window to optimize the routing plan of capacitated EVs and the strategy of charging stations. In particular, the strategy of charging stations includes both infrastructure-type selection and station location decisions. The problem accounts for two critical constraints in logistic practice: the vehicle loading capacity and the customer time windows. A hybrid heuristic that incorporates an adaptive variable neighborhood search (AVNS with the tabu search algorithm for intensification was developed to address the problem. The specialized neighborhood structures and the selection methods of charging station used in the shaking step of AVNS were proposed. In contrast to the commercial solver CPLEX, experimental results on small-scale test instances demonstrate that the algorithm can find nearly optimal solutions on small-scale instances. The results on large-scale instances also show the effectiveness of the algorithm.

  18. Managing truck arrivals with time windows to alleviate gate congestion at container terminals

    DEFF Research Database (Denmark)

    Chen, G.; Govindan, Kannan; Yang, Z.

    2013-01-01

    Long truck queues at gates often limit the efficiency of a container terminal and generate serious air pollution. To reduce the gate congestion, this paper proposes a method called'vessel dependent time windows (VDTWs)' to control truck arrivals, which involves partitioning truck entries into gro......Long truck queues at gates often limit the efficiency of a container terminal and generate serious air pollution. To reduce the gate congestion, this paper proposes a method called'vessel dependent time windows (VDTWs)' to control truck arrivals, which involves partitioning truck entries...... in the system. A conventional Genetic Algorithm (GA), a multi-society GA, and a hybrid algorithm using GA and Simulated Annealing are used to solve the optimization problem. A case study based on a real container terminal in China is performed, which shows the VDTWs method can flatten the truck arrivals...

  19. OPTIMIZING TIME WINDOWS FOR MANAGING ARRIVALS OF EXPORT CONTAINERS AT CHINESE CONTAINER TERMINALS

    DEFF Research Database (Denmark)

    Chen, Gang; Yang, Zhongzhen

    2009-01-01

      Managing the truck transport in a port area is important for Chinese container ports as heavy traffic congestion not only limits the terminal capacity but also generates serious air pollution. This paper explores an effective way to manage the truck traffic of export containers based on a time...... of driver and truck waiting time, the cost of container cargo storage time, the truck idle cost and terminal yard fee. Secondly, to minimize the costs, a heuristic is developed based on a genetic algorithm to optimize the time window arrangement. The optimal solution involves the position and the length...

  20. The waste collection vehicle routing problem with time windows in a city logistics context

    DEFF Research Database (Denmark)

    Buhrkal, Katja Frederik; Larsen, Allan; Røpke, Stefan

    2012-01-01

    Collection of waste is an important logistic activity within any city. In this paper we study how to collect waste in an efficient way. We study the Waste Collection Vehicle Routing Problem with Time Window which is concerned with finding cost optimal routes for garbage trucks such that all garbage...... by showing that the algorithm can improve the objective of a set of instances from the literature as well as for instances provided by a Danish garbage collection company....

  1. New heuristics for traveling salesman and vehicle routing problems with time windows

    Energy Technology Data Exchange (ETDEWEB)

    Gendreau, M.; Hertz, A.; Laporte, G.; Mihnea, S.

    1994-12-31

    We consider variants of the Traveling Salesman (TSP) and Vehicle Routing (VRP) Problems in which each customer can only be visited within a pre-specified (hard) time-window. We first present a two-phase (construction and post-optimization) generalized insertion heuristic for the TSPTW. This insertion heuristic is then imbedded in a tabu search metaheuristic in order to solve the VRPTW. Computational results on standard benchmark problems will be reported.

  2. Optimizing Ship Speed to Minimize Total Fuel Consumption with Multiple Time Windows

    Directory of Open Access Journals (Sweden)

    Jae-Gon Kim

    2016-01-01

    Full Text Available We study the ship speed optimization problem with the objective of minimizing the total fuel consumption. We consider multiple time windows for each port call as constraints and formulate the problem as a nonlinear mixed integer program. We derive intrinsic properties of the problem and develop an exact algorithm based on the properties. Computational experiments show that the suggested algorithm is very efficient in finding an optimal solution.

  3. Precise time-window for the onset of glacial termination found

    Science.gov (United States)

    Lai, C.-C.; Tseng, Y.-H.; Dietrich, D. E.

    2009-04-01

    MH and subsequent methane oxidation via bacteria. We postulate that the cooling of deep seawater when the insolation is weak leads to more hydrates ascending through seawater to the level for dissociation (which is a process depending on seawater temperature and pressure). The oxidation of CH4 and H2S after hydrate-dissociation is a multi-step process/phenomenon that we refer to as ocean slow-burn (OSB). It generates the maximum heat per mole of atom-C among all carbon-containing compounds, including sugars. Through oxidation, the CETP is now released as heat that is transferred via biomass, eventually being deposited into the seawater. Since the heat generated in the OSB is greater than that required to dissociate hydrates, they become self-sustained and run-away as long as all players (MH, bacteria, and methane ice worms (Fisher et al. 2000)) are present. So, the glacial termination is a process to release the stored CETP instead of trapping more insolation energy. (H4) Having accumulated enough energy sources, the OGT will happen when the joint effect of the three parameters triggers the discharge of the HCs. The trigger is an abrupt reduction in insolation over the Southern Oceans, especially South Atlantic under which lies the active Mid-Atlantic Ridge. The three rules were found through following steps: (1) finding a wide time-window (WTW) within which the energy (stored in hydrates) required to sustain a GT can be accumulated. (2) Then, we find a narrow time-window (NTW) (within that WTW) when the HC is abruptly cooled down due to a quick reduction in insolation. That NTW shall be the ideal time for the OGT. The variation of eccentricity is the factor controlling the annual global integral of insolation (AGII). The bigger the eccentricity the greater the AGII is. The greater the AGII the more the global CETP capture is. Presume that eccentricity varies like a sinusoidal function of time with a single period of 95 Ky. Then, the CETP being stored into the HCs

  4. Comparative Study of Single-glazed and Double-glazed Windows in Terms of Energy Efficiency and Economic Expenses

    Directory of Open Access Journals (Sweden)

    Samaneh Forughian

    2017-06-01

    Full Text Available Saving fossil fuels and the use of clean sources of energy lead to reduce in building operating costs, protect the environment and people's health. Windows are the most vulnerable part of building where energy loss occurs. Double-glazed windows are very effective in keeping inside temperature isolated from outside; thereby, saving electrical and thermal energy. The current study estimates the numerical changes in cooling and heating load in case of replacement double-glazed window with single-glazed window and calculates saving level for this replacement. In this context, this paper presents a model of real samples taken in Mashhad climate. To ensure the accuracy of the simulation results, real results were compared with electricity and gas bills. To calculate energy related parameters such as cooling load, heating load, the consumption of gas and electricity, the energy simulation software (Design Builder was used. The research method was a quantitative analysis based on energy consumption modeling, associated with building windows which comes in four sections. The field study was also used to compare with real electricity and gas bills. As the first stage, samples of the plan were identified, based on the observation of climate models and library studies. Then, simulation parameters such as window materials and internal and external walls were considered. The simulation was performed based software’s parameters and model limitations were determined based on thermal, lighting, climatic and architectural parameters. Finally, the experimental and practical data were used to determine the validity of the model under Mashhad climate conditions. Overall, the results indicated that double-glazed windows could save 50% of entire building loads, 0.2% on power consumption, 16.2% on gas and 12.4% on overall households’ energy consumption.

  5. CAVE WINDOW

    Science.gov (United States)

    Levenson, M.

    1960-10-25

    A cave window is described. It is constructed of thick glass panes arranged so that interior panes have smaller windowpane areas and exterior panes have larger areas. Exterior panes on the radiation exposure side are remotely replaceable when darkened excessively. Metal shutters minimize exposure time to extend window life.

  6. RENEW: a real-time and effective network emulator of windows for IPv6

    Science.gov (United States)

    Zhao, Bing; Jin, Zhigang; Shu, Yantai; Li, Yu; Cen, Dan

    2007-09-01

    Although IPv4 is still working, IPv6 is considered as the backbone and characteristic of the NGI. With the development of Internet, new protocols and network equipments are required to develop. It is necessary to test the new protocols and network equipments extensively before deployment. This paper proposes the design and implementation of RENEW, a useable and accurate network emulator which supports both IPv4 and IPv6 protocols. Besides, it also works on Windows platform. In our IPv6 testbed, we use RENEW to emulate various network characteristics and conditions including bandwidth, delay packet loss and jitter. Compared with the expected values, results are acceptable. Through implementation and experimentation study, we have shown that RENEW does provide the real-time control and change on the parameters of IPv6 network conditions effectively and expediently on Windows. It also gives enough accuracy and more satisfactory convenience to the development and test work for the new protocols.

  7. Lagrangian duality applied to the vehicle routing problem with time windows

    DEFF Research Database (Denmark)

    Kallehauge, Brian; Larsen, Jesper; Madsen, Oli B.G.

    2006-01-01

    This paper considers the vehicle routing problem with time windows, where the service of each customer must start within a specified time interval. We consider the Lagrangian relaxation of the constraint set requiring that each customer must be served by exactly one vehicle yielding a constrained......) algorithm for the VRPTW. Making use of this acceleration strategy at the master problem level gives a significant speed-up compared to algorithms in the literature based on traditional column generation. We have solved two test problems introduced in 2001 by Gehring and Homberger with 400 and 1000 customers...

  8. Reporting time of ischemic stroke patients within the time window for thrombolysis in a tertiary care hospital at rawalpindi

    International Nuclear Information System (INIS)

    Tariq, M.; Ishtiaq, S.; Anwar, S.O.

    2014-01-01

    To determine the reporting time of ischemic stroke patients within the time window for thrombolysis at Military Hospital (MH) Rawalpindi. Design: A descriptive study. Place and duration of Study: Military Hospital Rawalpindi over a period of four months from Dec 2013 to Mar 2014. Patients and Methods: Patients admitted to MH Rawalpindi with symptoms suggestive of stroke and having objective focal neurologic deficits consistent with stroke were included in the study. A CT scan of brain was carried out immediately to rule out intracranial bleed. The CT scan of brain was either normal or revealed radiological findings suggestive of an infarct. Results: A total of 86 patients met the inclusion criteria of the study. Only 19 (22%) patients with ischemic stroke presented to the hospital within 4.5 hours after onset of their symptoms. Conclusion: Only a small number of ischemic stroke patients report to the hospital within the therapeutic window for thrombolytic therapy. (author)

  9. Time relative single-photon (photoelectron) method

    International Nuclear Information System (INIS)

    Luo Binqiao

    1988-01-01

    A single-photon (photoelectron) measuring system is designed. It researches various problems in single-photon (photoelectron) method. The electronic resolving time is less than 25 ps. The resolving time of single-photon (photoelectron) measuring system is 25 to 65 ps

  10. A constructive heuristic for time-dependent multi-depot vehicle routing problem with time-windows and heterogeneous fleet

    Directory of Open Access Journals (Sweden)

    Behrouz Afshar-Nadjafi

    2017-01-01

    Full Text Available In this paper, we consider the time-dependent multi-depot vehicle routing problem. The objective is to minimize the total heterogeneous fleet cost assuming that the travel time between locations depends on the departure time. Also, hard time window constraints for the customers and limitation on maximum number of the vehicles in depots must be satisfied. The problem is formulated as a mixed integer programming model. A constructive heuristic procedure is proposed for the problem. Also, the efficiency of the proposed algorithm is evaluated on 180 test problems. The obtained computational results indicate that the procedure is capable to obtain a satisfying solution.

  11. Digitized detection of gamma-ray signals concentrated in narrow time windows for transient positron annihilation lifetime spectroscopy.

    Science.gov (United States)

    Kinomura, A; Suzuki, R; Oshima, N; O'Rourke, B E; Nishijima, T; Ogawa, H

    2014-12-01

    A pulsed slow-positron beam generated by an electron linear accelerator was directly used for positron annihilation lifetime spectroscopy without any positron storage devices. A waveform digitizer was introduced to simultaneously capture multiple gamma-ray signals originating from positron annihilation events during a single accelerator pulse. The positron pulse was chopped and bunched with the chopper signals also sent to the waveform digitizer. Time differences between the annihilation gamma-ray and chopper peaks were calculated and accumulated as lifetime spectra in a computer. The developed technique indicated that positron annihilation lifetime spectroscopy can be performed in a 20 μs time window at a pulse repetition rate synchronous with the linear accelerator. Lifetime spectra of a Kapton sheet and a thermally grown SiO2 layer on Si were successfully measured. Synchronization of positron lifetime measurements with pulsed ion irradiation was demonstrated by this technique.

  12. Analysis on Time Window of Shared Parking in Hospitals Based on Parking Behaviors

    Directory of Open Access Journals (Sweden)

    Qin Chen

    2017-01-01

    Full Text Available Hospitals are essential components of a city; huge traffic demand is generated and attracted, causing contradiction between parking supply and demand. By sharing parking berths, limited space can serve more demand which is beneficial to alleviating parking problems. Aimed at improving the capacity of shared parking, the paper analyzes four parking groups in typical hospitals, which are medical staff, outpatients, emergency patients, and visiting groups. The parking demand of medical staff is rigid. For outpatients and visiting groups, longer walking distance is acceptable and more attention is paid to parking fee. By contrast, emergency patients can accept shorter walking distance and focus more on convenience due to urgency. Under this circumstance, parking behaviors selection models are established by means of Multinomial Logit Model. On this basis, time value is adopted to calculate the tolerance of alterative parking time. Moreover, this paper explores the variation of time window, under different parking impedance. A case study is conducted and suggests that start and end point of a certain time window can be influenced by external factors.

  13. Impact of the time window on plasma volume measurement with indocyanine green

    International Nuclear Information System (INIS)

    Jacob, M; Chappell, D; Conzen, P; Finsterer, U; Rehm, M; Krafft, A; Becker, B F

    2008-01-01

    Recent reports have questioned the accuracy of the indocyanine green dilution technique for measuring plasma volume. Our objective was to evaluate the impact of different time windows for monoexponential extrapolation. We retrospectively analysed 31 indocyanine green decay curves to investigate the problem in principle (group 1) and prospectively performed another 21 plasma volume measurements to estimate its practical impact (group 2). To monoexponentially extrapolate back to the specific extinction at the time of dye injection, two different time windows were applied to each decay curve, comparing the plasma volumes resulting from sampling within a short (≤5 min) versus a longer (>5 min) period of time. Extrapolating back from the longer period led to a higher apparent plasma volume relative to the shorter period in both groups, the difference being 348 ± 171 ml (group 1) and 384 ± 131 ml (group 2; mean ± SD; p < 0.05 each). This result was due to a reliable monoexponentiality of decay only up to the 5th min after dye injection. Thus, to estimate the initial distribution space of indocyanine green via monoexponential extrapolation, the first linear kinetic of indocyanine green decay should be taken

  14. Collateral status affects the onset-to-reperfusion time window for good outcome.

    Science.gov (United States)

    Kim, Byung Moon; Baek, Jang-Hyun; Heo, Ji Hoe; Nam, Hyo Suk; Kim, Young Dae; Yoo, Joonsang; Kim, Dong Joon; Jeon, Pyoung; Baik, Seung Kug; Suh, Sang Hyun; Lee, Kyung Yol; Kwak, Hyo Sung; Roh, Hong Gee; Lee, Young-Jun; Kim, Sang Heum; Ryu, Chang-Woo; Ihn, Yon-Kwon; Kim, Byungjoon; Jeon, Hong Jun; Kim, Jin Woo; Byun, Jun Soo; Suh, Sangil; Park, Jeong Jin; Lee, Woong Jae; Roh, Jieun; Shin, Byoung-Soo; Bang, Oh Young

    2018-03-08

    To characterise the time window in which endovascular thrombectomy (EVT) is associated with good outcome, and to test the differential relationship between functional outcome and onset-to-reperfusion time (ORT), depending on collateral status. This was a retrospective analysis of clinical and imaging data of 554 consecutive patients, who had recanalisation success by EVT for anterior circulation large artery occlusion, from the prospectively maintained registries of 16 comprehensive stroke centres between September 2010 and December 2015. The patients were dichotomised into good and poor collateral groups, based on CT angiography. We tested whether the likelihood of good outcome (modified Rankin Scale, 0-2) by ORT was different between two groups. ORT was 298 min±113 min (range, 81-665 min), and 84.5% of patients had good collaterals. Age, diabetes mellitus, previous infarction, National Institutes of Health Stroke Scale, good collaterals (OR 40.766; 95% CI 10.668 to 155.78; pcollateral group (OR 0.305 for every 30 min; 95% CI 0.113 to 0.822) than in good collateral group (OR 0.926 for every 30 min; 95% CI 0.875 to 0.980). Earlier successful recanalisation was strongly associated with good outcome in poor collateral group; however, this association was weak during the tested time window in good collateral group. This suggests that the ORT window for good outcome can be adjusted according to collateral status. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  15. Partial path column generation for the vehicle routing problem with time windows

    DEFF Research Database (Denmark)

    Petersen, Bjørn; Jepsen, Mads Kehlet

    2009-01-01

    This paper presents a column generation algorithm for the Vehicle Routing Problem with Time Windows (VRPTW). Traditionally, column generation models of the VRPTW have consisted of a Set Partitioning master problem with each column representing a route, i.e., a resource feasible path starting...... number of customers. We suggest to relax that ‘each column is a route’ into ‘each column is a part of the giant tour’; a so-called partial path, i.e., not necessarily starting and ending in the depot. This way, the length of the partial path can be bounded and a better control of the size of the solution...

  16. VLSI Architectures for Sliding-Window-Based Space-Time Turbo Trellis Code Decoders

    Directory of Open Access Journals (Sweden)

    Georgios Passas

    2012-01-01

    Full Text Available The VLSI implementation of SISO-MAP decoders used for traditional iterative turbo coding has been investigated in the literature. In this paper, a complete architectural model of a space-time turbo code receiver that includes elementary decoders is presented. These architectures are based on newly proposed building blocks such as a recursive add-compare-select-offset (ACSO unit, A-, B-, Γ-, and LLR output calculation modules. Measurements of complexity and decoding delay of several sliding-window-technique-based MAP decoder architectures and a proposed parameter set lead to defining equations and comparison between those architectures.

  17. Methodology of mixed load customized bus lines and adjustment based on time windows

    Science.gov (United States)

    Song, Rui

    2018-01-01

    Custom bus routes need to be optimized to meet the needs of a customized bus for personalized trips of different passengers. This paper introduced a customized bus routing problem in which trips for each depot are given, and each bus stop has a fixed time window within which trips should be completed. Treating a trip as a virtual stop was the first consideration in solving the school bus routing problem (SBRP). Then, the mixed load custom bus routing model was established with a time window that satisfies its requirement and the result were solved by Cplex software. Finally, a simple network diagram with three depots, four pickup stops, and five delivery stops was structured to verify the correctness of the model, and based on the actual example, the result is that all the buses ran 124.42 kilometers, the sum of kilometers was 10.35 kilometers less than before. The paths and departure times of the different busses that were provided by the model were evaluated to meet the needs of the given conditions, thus providing valuable information for actual work. PMID:29320505

  18. A Hyperheuristic for the Dial-a-Ride Problem with Time Windows

    Directory of Open Access Journals (Sweden)

    Enrique Urra

    2015-01-01

    Full Text Available The dial-a-ride problem with time windows (DARPTW is a combinatorial optimization problem related to transportation, in which a set of customers must be picked up from an origin location and they have to be delivered to a destination location. A transportation schedule must be constructed for a set of available vehicles, and several constraints have to be considered, particularly time windows, which define an upper and lower time bound for each customer request in which a vehicle must arrive to perform the service. Because of the complexity of DARPTW, a number of algorithms have been proposed for solving the problem, mainly based on metaheuristics such as Genetic Algorithms and Simulated Annealing. In this work, a different approach for solving DARPTW is proposed, designed, and evaluated: hyperheuristics, which are alternative heuristic methods that operate at a higher abstraction level than metaheuristics, because rather than searching in the problem space directly, they search in a space of low-level heuristics to find the best strategy through which good solutions can be found. Although the proposed hyperheuristic uses simple and easy-to-implement operators, the experimental results demonstrate efficient and competitive performance on DARPTW when compared to other metaheuristics from the literature.

  19. No Specific Time Window Distinguishes between Community-, Healthcare-, and Hospital-Acquired Bacteremia, but They Are Prognostically Robust

    DEFF Research Database (Denmark)

    Gradel, Kim Oren; Nielsen, Stig Lønberg; Pedersen, Court

    2014-01-01

    mortality pertaining to bacteremia 0, 1, 2, …, 30, and 31 days and later after admission. Next, we assessed whether different admission (0-1, 0-2, 0-3, 0-7 days) and HCA (30, 90 days) time windows were associated with changes in odds ratio (OR) and area under the receiver operating characteristic (ROC......Objective. We examined whether specific time windows after hospital admission reflected a sharp transition between community and hospital acquisition of bacteremia. We further examined whether different time windows to distinguish between community acquisition, healthcare association (HCA......) curve for 30-day mortality, adjusting for sex, age, comorbidity, and microorganisms. Results. For 56,606 bacteremic episodes, no sharp transitions were detected on a specific day after admission. Among the 8 combined time windows, ORs for 30-day mortality varied from 1.30 (95% confidence interval [CI...

  20. Mathematical Formulation and Comparison of Solution Approaches for the Vehicle Routing Problem with Access Time Windows

    Directory of Open Access Journals (Sweden)

    Rafael Grosso

    2018-01-01

    Full Text Available The application of the principles of sustainability to the implementation of urban freight policies requires the estimation of all the costs and externalities involved. We focus here on the case of access time windows, which ban the access of freight vehicles to central urban areas in many European cities. Even though this measure seeks to reduce congestion and emissions in the most crowded periods of the day, it also imposes additional costs for carriers and results in higher emissions and energy consumption. We present here a mathematical model for the Vehicle Routing Problem with Access Time Windows, a variant of the VRP suitable for planning delivery routes in a city subject to this type of accessibility restriction. We use the model to find exact solutions to small problem instances based on a case study and then compare the performance over larger instances of a modified savings algorithm, a genetic algorithm, and a tabu search procedure, with the results showing no clear prevalence of any of them, but confirming the significance of those additional costs and externalities.

  1. The window of opportunity: decision theory and the timing of prognostic tests for newborn infants.

    Science.gov (United States)

    Wilkinson, Dominic

    2009-11-01

    In many forms of severe acute brain injury there is an early phase when prognosis is uncertain, followed later by physiological recovery and the possibility of more certain predictions of future impairment. There may be a window of opportunity for withdrawal of life support early, but if decisions are delayed there is the risk that the patient will survive with severe impairment. In this paper I focus on the example of neonatal encephalopathy and the question of the timing of prognostic tests and decisions to continue or to withdraw life-sustaining treatment. Should testing be performed early or later; and how should parents decide what to do given the conflicting values at stake? I apply decision theory to the problem, using sensitivity analysis to assess how different features of the tests or different values would affect a decision to perform early or late prognostic testing. I draw some general conclusions from this model for decisions about the timing of testing in neonatal encephalopathy. Finally I consider possible solutions to the problem posed by the window of opportunity. Decision theory highlights the costs of uncertainty. This may prompt further research into improving prognostic tests. But it may also prompt us to reconsider our current attitudes towards the palliative care of newborn infants predicted to be severely impaired.

  2. Predicting progression of mild cognitive impairment to dementia using neuropsychological data: a supervised learning approach using time windows.

    Science.gov (United States)

    Pereira, Telma; Lemos, Luís; Cardoso, Sandra; Silva, Dina; Rodrigues, Ana; Santana, Isabel; de Mendonça, Alexandre; Guerreiro, Manuela; Madeira, Sara C

    2017-07-19

    Predicting progression from a stage of Mild Cognitive Impairment to dementia is a major pursuit in current research. It is broadly accepted that cognition declines with a continuum between MCI and dementia. As such, cohorts of MCI patients are usually heterogeneous, containing patients at different stages of the neurodegenerative process. This hampers the prognostic task. Nevertheless, when learning prognostic models, most studies use the entire cohort of MCI patients regardless of their disease stages. In this paper, we propose a Time Windows approach to predict conversion to dementia, learning with patients stratified using time windows, thus fine-tuning the prognosis regarding the time to conversion. In the proposed Time Windows approach, we grouped patients based on the clinical information of whether they converted (converter MCI) or remained MCI (stable MCI) within a specific time window. We tested time windows of 2, 3, 4 and 5 years. We developed a prognostic model for each time window using clinical and neuropsychological data and compared this approach with the commonly used in the literature, where all patients are used to learn the models, named as First Last approach. This enables to move from the traditional question "Will a MCI patient convert to dementia somewhere in the future" to the question "Will a MCI patient convert to dementia in a specific time window". The proposed Time Windows approach outperformed the First Last approach. The results showed that we can predict conversion to dementia as early as 5 years before the event with an AUC of 0.88 in the cross-validation set and 0.76 in an independent validation set. Prognostic models using time windows have higher performance when predicting progression from MCI to dementia, when compared to the prognostic approach commonly used in the literature. Furthermore, the proposed Time Windows approach is more relevant from a clinical point of view, predicting conversion within a temporal interval

  3. Penanganan Fuzzy Time Window pada Travelling Salesman Problem (TSP dengan Penerapan Algoritma Genetika

    Directory of Open Access Journals (Sweden)

    Gusti Eka Yuliastuti

    2017-03-01

    Full Text Available The route of the travel tour packages offered by travel agents is not considered optimum, so the level of satisfaction the tourist is not maximal. Selection of the route of the travel packages included in the traveling salesman problem (TSP. The problem that occurs is uncertain tourists visiting destinations at the best destinations timing hereinafter be referred to as the fuzzy time window problem. Therefore, the authors apply the genetic algorithm to solve the problem. Based on test results obtained optimum solution with the fitness value of 1.3291, a population size of 100, the number of generations of 1000, a combination of CR=0,4 and MR=0.6.

  4. The Electric Fleet Size and Mix Vehicle Routing Problem with Time Windows and Recharging Stations

    DEFF Research Database (Denmark)

    Hiermann, Gerhard; Puchinger, Jakob; Røpke, Stefan

    2016-01-01

    Due to new regulations and further technological progress in the field of electric vehicles, the research community faces the new challenge of incorporating the electric energy based restrictions into vehicle routing problems. One of these restrictions is the limited battery capacity which makes......-FSMFTW) to model decisions to be made with regards to fleet composition and the actual vehicle routes including the choice of recharging times and locations. The available vehicle types differ in their transport capacity, battery size and acquisition cost. Furthermore, we consider time windows at customer...... locations, which is a common and important constraint in real-world routing and planning problems. We solve this problem by means of branch-and-price as well as proposing a hybrid heuristic, which combines an Adaptive Large Neighbourhood Search with an embedded local search and labeling procedure...

  5. Subset-row inequalities applied to the vehicle routing problem with time windows

    DEFF Research Database (Denmark)

    Jepsen, Mads Kehlet; Petersen, Bjørn; Spoorendonk, Simon

    2008-01-01

    constraints as the pricing problem. We introduce the subset-row inequalities, which are Chvatal-Gomory rank-1 cuts based on a subset of the constraints in the master problem. Applying a subset-row inequality in the master problem increases the complexity of the label-setting algorithm used to solve......This paper presents a branch-and-cut-and-price algorithm for the vehicle-routing problem with time windows. The standard Dantzig-Wolfe decomposition of the arc flow formulation leads to a set-partitioning problem as the master problem and an elementary shortest-path problem with resource...... the pricing problem because an additional resource is added for each inequality. We propose a modified dominance criterion that makes it possible to dominate more labels by exploiting the step-like structure of the objective function of the pricing problem. Computational experiments have been performed...

  6. Clique inequalities applied to the vehicle routing problem with time windows

    DEFF Research Database (Denmark)

    Spoorendonk, Simon; Desaulniers, Guy

    2010-01-01

    This work presents an exact branch-cut-and-price algorithm for the vehicle routing problem with time windows (VRPTW) where the well-known clique inequalities are used as cutting planes defined on the set partitioning master problem variables. It shows how these cutting planes affect the dominance...... criterion applied in the pricing algorithm, which is a labeling algorithm for solving resource-constrained elementary shortest path problems. The idea of using cutting planes defined on the master problem variables for the VRPTW has been recently developed: Chva´tal-Gomory rank-1 cuts were applied. However......, to our knowledge, this is a first attempt at incorporating for the VRPTW a set of valid inequalities specialized for the set partitioning polytope. Computational results show that the use of clique inequalities improves the lower bound at the root node of the search tree and reduces the number of nodes...

  7. A Combination of Genetic Algorithm and Particle Swarm Optimization for Vehicle Routing Problem with Time Windows

    Science.gov (United States)

    Xu, Sheng-Hua; Liu, Ji-Ping; Zhang, Fu-Hao; Wang, Liang; Sun, Li-Jian

    2015-01-01

    A combination of genetic algorithm and particle swarm optimization (PSO) for vehicle routing problems with time windows (VRPTW) is proposed in this paper. The improvements of the proposed algorithm include: using the particle real number encoding method to decode the route to alleviate the computation burden, applying a linear decreasing function based on the number of the iterations to provide balance between global and local exploration abilities, and integrating with the crossover operator of genetic algorithm to avoid the premature convergence and the local minimum. The experimental results show that the proposed algorithm is not only more efficient and competitive with other published results but can also obtain more optimal solutions for solving the VRPTW issue. One new well-known solution for this benchmark problem is also outlined in the following. PMID:26343655

  8. A critical time window for organismal interactions in a pelagic ecosystem.

    Directory of Open Access Journals (Sweden)

    Kelly J Benoit-Bird

    Full Text Available To measure organismal coherence in a pelagic ecosystem, we used moored sensors to describe the vertical dynamics of each step in the food chain in shelf waters off the west shore of Oahu, Hawaii. Horizontally extensive, intense aggregations of phytoplankton, zooplankton, and micronekton exhibited strong diel patterns in abundance and vertical distribution, resulting in a highly variable potential for interaction amongst trophic levels. Only around dusk did zooplankton layers overlap with phytoplankton layers. Shortly after sunset, micronekton ascended from the deep, aggregating on the island's shelf. Short-lived departures in migration patterns were detected in depth, vertical distribution, density, and total abundance of micronekton when zooplankton layers were present with typical patterns resuming within one hour. Layers of zooplankton began to disappear within 20 minutes of the arrival of micronekton with no layers present after 50 minutes. The effects of zooplankton layers cascaded even further up the food chain, affecting many behaviors of dolphins observed at dusk including their depth, group size, and inter-individual spacing. As a result of these changes in behavior, during a 30-minute window just after dusk, the number of feeding events observed for each dolphin and consequently the feeding time for each individual more than doubled when zooplankton layers were present. Dusk is a critical period for interactions amongst species in this system from phytoplankton to top predators. Our observations that short time windows can drive the structure and function of a complex suite of organisms highlight the importance of explicitly adding a temporal dimension at a scale relevant to individual organisms to our descriptions of heterogeneity in ocean ecosystems.

  9. Application of the multi-objective cross-entropy method to the vehicle routing problem with soft time windows

    Directory of Open Access Journals (Sweden)

    C Hauman

    2014-06-01

    Full Text Available The vehicle routing problem with time windows is a widely studied problem with many real-world applications. The problem considered here entails the construction of routes that a number of identical vehicles travel to service different nodes within a certain time window. New benchmark problems with multi-objective features were recently suggested in the literature and the multi-objective optimisation cross-entropy method is applied to these problems to investigate the feasibility of the method and to determine and propose reference solutions for the benchmark problems. The application of the cross-entropy method to the multi-objective vehicle routing problem with soft time windows is investigated. The objectives that are evaluated include the minimisation of the total distance travelled, the number of vehicles and/or routes, the total waiting time and delay time of the vehicles and the makespan of a route.

  10. Branch and price for the time-dependent vehicle routing problem with time windows

    DEFF Research Database (Denmark)

    Dabia, Said; Dabia, Said; Van Woensel, Tom

    2013-01-01

    solution methods to the DM-TDVRPTW are based on (meta-)heuristics. The decomposition of an arc-based formulation leads to a setpartitioning problem as the master problem, and a time-dependent shortest path problem with resource constraints as the pricing problem. The master problem is solved by means...

  11. Window Regression: A Spatial-Temporal Analysis to Estimate Pixels Classified as Low-Quality in MODIS NDVI Time Series

    Directory of Open Access Journals (Sweden)

    Julio Cesar de Oliveira

    2014-04-01

    Full Text Available MODerate resolution Imaging Spectroradiometer (MODIS data are largely used in multitemporal analysis of various Earth-related phenomena, such as vegetation phenology, land use/land cover change, deforestation monitoring, and time series analysis. In general, the MODIS products used to undertake multitemporal analysis are composite mosaics of the best pixels over a certain period of time. However, it is common to find bad pixels in the composition that affect the time series analysis. We present a filtering methodology that considers the pixel position (location in space and time (position in the temporal data series to define a new value for the bad pixel. This methodology, called Window Regression (WR, estimates the value of the point of interest, based on the regression analysis of the data selected by a spatial-temporal window. The spatial window is represented by eight pixels neighboring the pixel under evaluation, and the temporal window selects a set of dates close to the date of interest (either earlier or later. Intensities of noises were simulated over time and space, using the MOD13Q1 product. The method presented and other techniques (4253H twice, Mean Value Iteration (MVI and Savitzky–Golay were evaluated using the Mean Absolute Percentage Error (MAPE and Akaike Information Criteria (AIC. The tests revealed the consistently superior performance of the Window Regression approach to estimate new Normalized Difference Vegetation Index (NDVI values irrespective of the intensity of the noise simulated.

  12. Mining Frequent Item Sets in Asynchronous Transactional Data Streams over Time Sensitive Sliding Windows Model

    International Nuclear Information System (INIS)

    Javaid, Q.; Memon, F.; Talpur, S.; Arif, M.; Awan, M.D.

    2016-01-01

    EPs (Extracting Frequent Patterns) from the continuous transactional data streams is a challenging and critical task in some of the applications, such as web mining, data analysis and retail market, prediction and network monitoring, or analysis of stock market exchange data. Many algorithms have been developed previously for mining FPs (Frequent Patterns) from a data stream. Such algorithms are currently highly required to develop new solutions and approaches to the precise handling of data streams. New techniques, solutions, or approaches are developed to address unbounded, ordered, and continuous sequences of data and for the generation of data at a rapid speed from data streams. Hence, extracting FPs using fresh or recent data involves the high-level analysis of data streams. We have suggested an efficient technique for the window sliding model; this technique extracts new and fresh FPs from high-speed data streams. In this study, a CPILT (Compacted Tree Compact Pattern Tree) is developed to capture the latest contents in the stream and to efficiently remove outdated contents from the data stream. The main concept introduced in this work on CPILT is the dynamic restructuring of a tree, which is helpful in producing a compacted tree and the frequency descending structure of a tree on runtime. With the help of the mining technique of FP growth, a complete list of new and fresh FPs is obtained from a CPILT using an existing window. The memory usage and time complexity of the latest FPs in high-speed data streams can efficiently be determined through proper experimentation and analysis. (author)

  13. The multi-depot electric vehicle location routing problem with time windows

    Directory of Open Access Journals (Sweden)

    Juan Camilo Paz

    2018-01-01

    Full Text Available In this paper, the Multi-Depot Electric Vehicle Location Routing Problem with Time Windows (MDVLRP is addressed. This problem is an extension of the MDVLRP, where electric vehicles are used instead of internal combustion engine vehicles. The recent development of this model is explained by the advantages of this technology, such as the diminution of carbon dioxide emissions, and the support that they can provide to the design of the logistic and energy-support structure of electric vehicle fleets. There are many models that extend the classical VRP model to take electric vehicles into consideration, but the multi-depot case for location-routing models has not been worked out yet. Moreover, we consider the availability of two energy supply technologies: the “Plug-in” Conventional Charge technology, and Battery Swapping Stations; options in which the recharging time is a function of the amount of energy to charge and a fixed time, respectively. Three models are proposed: one for each of the technologies mentioned above, and another in which both options are taken in consideration. The models were solved for small scale instances using C++ and Cplex 12.5. The results show that the models can be used to design logistic and energy-support structures, and compare the performance of the different options of energy supply, as well as measure the impact of these decisions on the overall distance traveled or other optimization objectives that could be worked on in the future.

  14. Nutrient timing revisited: is there a post-exercise anabolic window?

    Directory of Open Access Journals (Sweden)

    Aragon Alan Albert

    2013-01-01

    Full Text Available Abstract Nutrient timing is a popular nutritional strategy that involves the consumption of combinations of nutrients--primarily protein and carbohydrate--in and around an exercise session. Some have claimed that this approach can produce dramatic improvements in body composition. It has even been postulated that the timing of nutritional consumption may be more important than the absolute daily intake of nutrients. The post-exercise period is widely considered the most critical part of nutrient timing. Theoretically, consuming the proper ratio of nutrients during this time not only initiates the rebuilding of damaged muscle tissue and restoration of energy reserves, but it does so in a supercompensated fashion that enhances both body composition and exercise performance. Several researchers have made reference to an anabolic “window of opportunity” whereby a limited time exists after training to optimize training-related muscular adaptations. However, the importance - and even the existence - of a post-exercise ‘window’ can vary according to a number of factors. Not only is nutrient timing research open to question in terms of applicability, but recent evidence has directly challenged the classical view of the relevance of post-exercise nutritional intake with respect to anabolism. Therefore, the purpose of this paper will be twofold: 1 to review the existing literature on the effects of nutrient timing with respect to post-exercise muscular adaptations, and; 2 to draw relevant conclusions that allow practical, evidence-based nutritional recommendations to be made for maximizing the anabolic response to exercise.

  15. Time stamping of single optical photons with 10 ns resolution

    Science.gov (United States)

    Chakaberia, Irakli; Cotlet, Mircea; Fisher-Levine, Merlin; Hodges, Diedra R.; Nguyen, Jayke; Nomerotski, Andrei

    2017-05-01

    High spatial and temporal resolution are key features for many modern applications, e.g. mass spectrometry, probing the structure of materials via neutron scattering, studying molecular structure, etc.1-5 Fast imaging also provides the capability of coincidence detection, and the further addition of sensitivity to single optical photons with the capability of timestamping them further broadens the field of potential applications. Photon counting is already widely used in X-ray imaging,6 where the high energy of the photons makes their detection easier. TimepixCam is a novel optical imager,7 which achieves high spatial resolution using an array of 256×256 55 μm × 55μm pixels which have individually controlled functionality. It is based on a thin-entrance-window silicon sensor, bump-bonded to a Timepix ASIC.8 TimepixCam provides high quantum efficiency in the optical wavelength range (400-1000 nm). We perform the timestamping of single photons with a time resolution of 20 ns, by coupling TimepixCam to a fast image-intensifier with a P47 phosphor screen. The fast emission time of the P479 allows us to preserve good time resolution while maintaining the capability to focus the optical output of the intensifier onto the 256×256 pixel Timepix sensor area. We demonstrate the capability of the (TimepixCam + image intensifier) setup to provide high-resolution single-photon timestamping, with an effective frame rate of 50 MHz.

  16. MASMA: a versatile multifunctional unit (gated window amplifier, analog memory, and height-to-time converter)

    International Nuclear Information System (INIS)

    Goursky, V.; Thenes, P.

    1969-01-01

    This multipurpose unit is designed to accomplish one of the following functions: - gated window amplifier, - Analog memory and - Amplitude-to-time converter. The first function is mainly devoted to improve the poor resolution of pulse-height analyzers with a small number of channels. The analog memory, a new function in the standard range of plug-in modules, is capable of performing a number of operations: 1) fixed delay, or variable delay dependent on an external parameter (application to the analog processing of non-coincident pulses), 2) de-randomiser to increase the efficiency of the pulse height analysis in a spectrometry experiment, 3) linear multiplexer to allow an analyser to serve as many spectrometry devices as memory elements that it possesses. Associated with a coding scaler, this unit, if used as a amplitude-to-time converter, constitutes a Wilkinson A.D.C with a capability of 10 bits (or more) and with a 100 MHz clock frequency. (authors) [fr

  17. Therapeutic Time Window for Edaravone Treatment of Traumatic Brain Injury in Mice

    Directory of Open Access Journals (Sweden)

    Kazuyuki Miyamoto

    2013-01-01

    Full Text Available Traumatic brain injury (TBI is a major cause of death and disability in young people. No effective therapy is available to ameliorate its damaging effects. Our aim was to investigate the optimal therapeutic time window of edaravone, a free radical scavenger which is currently used in Japan. We also determined the temporal profile of reactive oxygen species (ROS production, oxidative stress, and neuronal death. Male C57Bl/6 mice were subjected to a controlled cortical impact (CCI. Edaravone (3.0 mg/kg, or vehicle, was administered intravenously at 0, 3, or 6 hours following CCI. The production of superoxide radicals (O2∙- as a marker of ROS, of nitrotyrosine (NT as an indicator of oxidative stress, and neuronal death were measured for 24 hours following CCI. Superoxide radical production was clearly evident 3 hours after CCI, with oxidative stress and neuronal cell death becoming apparent after 6 hours. Edaravone administration after CCI resulted in a significant reduction in the injury volume and oxidative stress, particularly at the 3-hour time point. Moreover, the greatest decrease in O2∙- levels was observed when edaravone was administered 3 hours following CCI. These findings suggest that edaravone could prove clinically useful to ameliorate the devastating effects of TBI.

  18. Multisensory integration: the case of a time window of gesture-speech integration.

    Science.gov (United States)

    Obermeier, Christian; Gunter, Thomas C

    2015-02-01

    This experiment investigates the integration of gesture and speech from a multisensory perspective. In a disambiguation paradigm, participants were presented with short videos of an actress uttering sentences like "She was impressed by the BALL, because the GAME/DANCE...." The ambiguous noun (BALL) was accompanied by an iconic gesture fragment containing information to disambiguate the noun toward its dominant or subordinate meaning. We used four different temporal alignments between noun and gesture fragment: the identification point (IP) of the noun was either prior to (+120 msec), synchronous with (0 msec), or lagging behind the end of the gesture fragment (-200 and -600 msec). ERPs triggered to the IP of the noun showed significant differences for the integration of dominant and subordinate gesture fragments in the -200, 0, and +120 msec conditions. The outcome of this integration was revealed at the target words. These data suggest a time window for direct semantic gesture-speech integration ranging from at least -200 up to +120 msec. Although the -600 msec condition did not show any signs of direct integration at the homonym, significant disambiguation was found at the target word. An explorative analysis suggested that gesture information was directly integrated at the verb, indicating that there are multiple positions in a sentence where direct gesture-speech integration takes place. Ultimately, this would implicate that in natural communication, where a gesture lasts for some time, several aspects of that gesture will have their specific and possibly distinct impact on different positions in an utterance.

  19. A HYBRID GENETIC ALGORITHM IMPLEMENTATION FOR VEHICLE ROUTING PROBLEM WITH TIME WINDOWS

    Directory of Open Access Journals (Sweden)

    Muhammad Faisal Ibrahim

    2016-01-01

    Full Text Available This article is related to approach development in order to determine the most appropriate route for bottled water delivery from warehouse to retail from particular boundaries such as a limit on number of vehicle, vehicle capacity, and time windows to each retail. A mathematical model of VRPTW is adopted to solve the problem. Malang is one of the drinking water production centers in Indonesia, definitely it will be difficult for the company to determine the optimal delivery route with the existing restrictions. In this research hybrid genetic algorithm is use to determine the route shipping companies with the Java programming language. After analyzing the results obtained show that the results of the implementation of hybrid genetic algorithm is better than the company actual route. Moreover, authors also analyze the effect the number of iterations for the computation time, and the influence the number of iterations for the fitness value or violation. This algorithm can be applied for the routing and the result obtained is an optimal solution

  20. Determination of Equine Cytochrome c Backbone Amide Hydrogen/Deuterium Exchange Rates by Mass Spectrometry Using a Wider Time Window and Isotope Envelope.

    Science.gov (United States)

    Hamuro, Yoshitomo

    2017-03-01

    A new strategy to analyze amide hydrogen/deuterium exchange mass spectrometry (HDX-MS) data is proposed, utilizing a wider time window and isotope envelope analysis of each peptide. While most current scientific reports present HDX-MS data as a set of time-dependent deuteration levels of peptides, the ideal HDX-MS data presentation is a complete set of backbone amide hydrogen exchange rates. The ideal data set can provide single amide resolution, coverage of all exchange events, and the open/close ratio of each amide hydrogen in EX2 mechanism. Toward this goal, a typical HDX-MS protocol was modified in two aspects: measurement of a wider time window in HDX-MS experiments and deconvolution of isotope envelope of each peptide. Measurement of a wider time window enabled the observation of deuterium incorporation of most backbone amide hydrogens. Analysis of the isotope envelope instead of centroid value provides the deuterium distribution instead of the sum of deuteration levels in each peptide. A one-step, global-fitting algorithm optimized exchange rate and deuterium retention during the analysis of each amide hydrogen by fitting the deuterated isotope envelopes at all time points of all peptides in a region. Application of this strategy to cytochrome c yielded 97 out of 100 amide hydrogen exchange rates. A set of exchange rates determined by this approach is more appropriate for a patent or regulatory filing of a biopharmaceutical than a set of peptide deuteration levels obtained by a typical protocol. A wider time window of this method also eliminates false negatives in protein-ligand binding site identification. Graphical Abstract ᅟ.

  1. Determination of Equine Cytochrome c Backbone Amide Hydrogen/Deuterium Exchange Rates by Mass Spectrometry Using a Wider Time Window and Isotope Envelope

    Science.gov (United States)

    Hamuro, Yoshitomo

    2017-03-01

    A new strategy to analyze amide hydrogen/deuterium exchange mass spectrometry (HDX-MS) data is proposed, utilizing a wider time window and isotope envelope analysis of each peptide. While most current scientific reports present HDX-MS data as a set of time-dependent deuteration levels of peptides, the ideal HDX-MS data presentation is a complete set of backbone amide hydrogen exchange rates. The ideal data set can provide single amide resolution, coverage of all exchange events, and the open/close ratio of each amide hydrogen in EX2 mechanism. Toward this goal, a typical HDX-MS protocol was modified in two aspects: measurement of a wider time window in HDX-MS experiments and deconvolution of isotope envelope of each peptide. Measurement of a wider time window enabled the observation of deuterium incorporation of most backbone amide hydrogens. Analysis of the isotope envelope instead of centroid value provides the deuterium distribution instead of the sum of deuteration levels in each peptide. A one-step, global-fitting algorithm optimized exchange rate and deuterium retention during the analysis of each amide hydrogen by fitting the deuterated isotope envelopes at all time points of all peptides in a region. Application of this strategy to cytochrome c yielded 97 out of 100 amide hydrogen exchange rates. A set of exchange rates determined by this approach is more appropriate for a patent or regulatory filing of a biopharmaceutical than a set of peptide deuteration levels obtained by a typical protocol. A wider time window of this method also eliminates false negatives in protein-ligand binding site identification.

  2. Comparison of the Time Domain Windows Specified in the ISO 18431 Standards Used to Estimate Modal Parameters in Steel Plates

    Directory of Open Access Journals (Sweden)

    Jhonatan Camacho-Navarro

    2016-01-01

    Full Text Available The procedures used to estimate structural modal parameters as natural frequency, damping ratios, and mode shapes are generally based on frequency methods. However, methods of time-frequency analysis are highly sensible to the parameters used to calculate the discrete Fourier transform: windowing, resolution, and preprocessing. Thus, the uncertainty of the modal parameters is increased if a proper parameter selection is not considered. In this work, the influence of three different time domain windows functions (Hanning, flat-top, and rectangular used to estimate modal parameters are discussed in the framework of ISO 18431 standard. Experimental results are conducted over an AISI 1020 steel plate, which is excited by means of a hammer element. Vibration response is acquired by using acceleration records according to the ISO 7626-5 reference guides. The results are compared with a theoretical method and it is obtained that the flat-top window is the best function for experimental modal analysis.

  3. Face perception is tuned to horizontal orientation in the N170 time window.

    Science.gov (United States)

    Jacques, Corentin; Schiltz, Christine; Goffaux, Valerie

    2014-02-07

    The specificity of face perception is thought to reside both in its dramatic vulnerability to picture-plane inversion and its strong reliance on horizontally oriented image content. Here we asked when in the visual processing stream face-specific perception is tuned to horizontal information. We measured the behavioral performance and scalp event-related potentials (ERP) when participants viewed upright and inverted images of faces and cars (and natural scenes) that were phase-randomized in a narrow orientation band centered either on vertical or horizontal orientation. For faces, the magnitude of the inversion effect (IE) on behavioral discrimination performance was significantly reduced for horizontally randomized compared to vertically or nonrandomized images, confirming the importance of horizontal information for the recruitment of face-specific processing. Inversion affected the processing of nonrandomized and vertically randomized faces early, in the N170 time window. In contrast, the magnitude of the N170 IE was much smaller for horizontally randomized faces. The present research indicates that the early face-specific neural representations are preferentially tuned to horizontal information and offers new perspectives for a description of the visual information feeding face-specific perception.

  4. Modified artificial bee colony for the vehicle routing problems with time windows.

    Science.gov (United States)

    Alzaqebah, Malek; Abdullah, Salwani; Jawarneh, Sana

    2016-01-01

    The natural behaviour of the honeybee has attracted the attention of researchers in recent years and several algorithms have been developed that mimic swarm behaviour to solve optimisation problems. This paper introduces an artificial bee colony (ABC) algorithm for the vehicle routing problem with time windows (VRPTW). A Modified ABC algorithm is proposed to improve the solution quality of the original ABC. The high exploration ability of the ABC slows-down its convergence speed, which may due to the mechanism used by scout bees in replacing abandoned (unimproved) solutions with new ones. In the Modified ABC a list of abandoned solutions is used by the scout bees to memorise the abandoned solutions, then the scout bees select a solution from the list based on roulette wheel selection and replace by a new solution with random routs selected from the best solution. The performance of the Modified ABC is evaluated on Solomon benchmark datasets and compared with the original ABC. The computational results demonstrate that the Modified ABC outperforms the original ABC also produce good solutions when compared with the best-known results in the literature. Computational investigations show that the proposed algorithm is a good and promising approach for the VRPTW.

  5. Spatial, temporal, and hybrid decompositions for large-scale vehicle routing with time windows

    Energy Technology Data Exchange (ETDEWEB)

    Bent, Russell W [Los Alamos National Laboratory

    2010-01-01

    This paper studies the use of decomposition techniques to quickly find high-quality solutions to large-scale vehicle routing problems with time windows. It considers an adaptive decomposition scheme which iteratively decouples a routing problem based on the current solution. Earlier work considered vehicle-based decompositions that partitions the vehicles across the subproblems. The subproblems can then be optimized independently and merged easily. This paper argues that vehicle-based decompositions, although very effective on various problem classes also have limitations. In particular, they do not accommodate temporal decompositions and may produce spatial decompositions that are not focused enough. This paper then proposes customer-based decompositions which generalize vehicle-based decouplings and allows for focused spatial and temporal decompositions. Experimental results on class R2 of the extended Solomon benchmarks demonstrates the benefits of the customer-based adaptive decomposition scheme and its spatial, temporal, and hybrid instantiations. In particular, they show that customer-based decompositions bring significant benefits over large neighborhood search in contrast to vehicle-based decompositions.

  6. A Hybrid Chaos-Particle Swarm Optimization Algorithm for the Vehicle Routing Problem with Time Window

    Directory of Open Access Journals (Sweden)

    Qi Hu

    2013-04-01

    Full Text Available State-of-the-art heuristic algorithms to solve the vehicle routing problem with time windows (VRPTW usually present slow speeds during the early iterations and easily fall into local optimal solutions. Focusing on solving the above problems, this paper analyzes the particle encoding and decoding strategy of the particle swarm optimization algorithm, the construction of the vehicle route and the judgment of the local optimal solution. Based on these, a hybrid chaos-particle swarm optimization algorithm (HPSO is proposed to solve VRPTW. The chaos algorithm is employed to re-initialize the particle swarm. An efficient insertion heuristic algorithm is also proposed to build the valid vehicle route in the particle decoding process. A particle swarm premature convergence judgment mechanism is formulated and combined with the chaos algorithm and Gaussian mutation into HPSO when the particle swarm falls into the local convergence. Extensive experiments are carried out to test the parameter settings in the insertion heuristic algorithm and to evaluate that they are corresponding to the data’s real-distribution in the concrete problem. It is also revealed that the HPSO achieves a better performance than the other state-of-the-art algorithms on solving VRPTW.

  7. Stress within a Restricted Time Window Selectively Affects the Persistence of Long-Term Memory

    Science.gov (United States)

    Fang, Qin; Chai, Ning; Zhao, Li-Yan; Xue, Yan-Xue; Luo, Yi-Xiao; Jian, Min; Han, Ying; Shi, Hai-Shui; Lu, Lin; Wu, Ping; Wang, Ji-Shi

    2013-01-01

    The effects of stress on emotional memory are distinct and depend on the stages of memory. Memory undergoes consolidation and reconsolidation after acquisition and retrieval, respectively. Stress facilitates the consolidation but disrupts the reconsolidation of emotional memory. Previous research on the effects of stress on memory have focused on long-term memory (LTM) formation (tested 24 h later), but the effects of stress on the persistence of LTM (tested at least 1 week later) are unclear. Recent findings indicated that the persistence of LTM requires late-phase protein synthesis in the dorsal hippocampus. The present study investigated the effect of stress (i.e., cold water stress) during the late phase after the acquisition and retrieval of contextual fear memory in rats. We found that stress and corticosterone administration during the late phase (12 h) after acquisition, referred to as late consolidation, selectively enhanced the persistence of LTM, whereas stress during the late phase (12 h) after retrieval, referred to as late reconsolidation, selectively disrupted the restabilized persistence of LTM. Moreover, the effects of stress on the persistence of LTM were blocked by the corticosterone synthesis inhibitor metyrapone, which was administered before stress, suggesting that the glucocorticoid system is involved in the effects of stress on the persistence of LTM. We conclude that stress within a restricted time window after acquisition or retrieval selectively affects the persistence of LTM and depends on the glucocorticoid system. PMID:23544051

  8. The time window for successful right-hemispheric language reorganization in children.

    Science.gov (United States)

    Lidzba, Karen; Küpper, Hanna; Kluger, Gerhard; Staudt, Martin

    2017-09-01

    To identify, in a retrospective, observational study, the time window during which successful right-hemispheric language reorganization is possible after left-hemispheric brain damage. 25 patients (10 females; age 6-41 years; ≥12 months after insult; age at insult 0;3-15;11 years) with acute, language-relevant left-hemispheric insults acquired during childhood and adolescence completed questionnaires for self-assessment of language problems. 12 patients of those reporting no (n = 8) or only moderate (n = 4) language problems participated in language fMRI. Language outcome of lesions occurring before 5 years of age (n = 7) was always favorable, and language was right-lateralized (2 patients: age at lesion reorganization (fMRI available in 4). The combination of normal language outcome and right-hemispheric language reorganization after a left-hemispheric lesion sustained after the neonatal period is extremely rare. Functionally sufficient right-hemispheric language was documented in only two patients with lesions acquired before two years of age. Copyright © 2017 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

  9. Stress within a restricted time window selectively affects the persistence of long-term memory.

    Directory of Open Access Journals (Sweden)

    Chang Yang

    Full Text Available The effects of stress on emotional memory are distinct and depend on the stages of memory. Memory undergoes consolidation and reconsolidation after acquisition and retrieval, respectively. Stress facilitates the consolidation but disrupts the reconsolidation of emotional memory. Previous research on the effects of stress on memory have focused on long-term memory (LTM formation (tested 24 h later, but the effects of stress on the persistence of LTM (tested at least 1 week later are unclear. Recent findings indicated that the persistence of LTM requires late-phase protein synthesis in the dorsal hippocampus. The present study investigated the effect of stress (i.e., cold water stress during the late phase after the acquisition and retrieval of contextual fear memory in rats. We found that stress and corticosterone administration during the late phase (12 h after acquisition, referred to as late consolidation, selectively enhanced the persistence of LTM, whereas stress during the late phase (12 h after retrieval, referred to as late reconsolidation, selectively disrupted the restabilized persistence of LTM. Moreover, the effects of stress on the persistence of LTM were blocked by the corticosterone synthesis inhibitor metyrapone, which was administered before stress, suggesting that the glucocorticoid system is involved in the effects of stress on the persistence of LTM. We conclude that stress within a restricted time window after acquisition or retrieval selectively affects the persistence of LTM and depends on the glucocorticoid system.

  10. Impact of an observational time window on coupled data assimilation: simulation with a simple climate model

    Directory of Open Access Journals (Sweden)

    Y. Zhao

    2017-11-01

    Full Text Available Climate signals are the results of interactions of multiple timescale media such as the atmosphere and ocean in the coupled earth system. Coupled data assimilation (CDA pursues balanced and coherent climate analysis and prediction initialization by incorporating observations from multiple media into a coupled model. In practice, an observational time window (OTW is usually used to collect measured data for an assimilation cycle to increase observational samples that are sequentially assimilated with their original error scales. Given different timescales of characteristic variability in different media, what are the optimal OTWs for the coupled media so that climate signals can be most accurately recovered by CDA? With a simple coupled model that simulates typical scale interactions in the climate system and twin CDA experiments, we address this issue here. Results show that in each coupled medium, an optimal OTW can provide maximal observational information that best fits the characteristic variability of the medium during the data blending process. Maintaining correct scale interactions, the resulting CDA improves the analysis of climate signals greatly. These simple model results provide a guideline for when the real observations are assimilated into a coupled general circulation model for improving climate analysis and prediction initialization by accurately recovering important characteristic variability such as sub-diurnal in the atmosphere and diurnal in the ocean.

  11. Gas flushing through hyper-acidic crater lakes: the next steps within a reframed monitoring time window

    Science.gov (United States)

    Rouwet, Dmitri

    2016-04-01

    evaporative degassing plumes can be useful as monitoring tool on the short-term, but only if the underlying process of gas flushing through acidic lakes is better understood, and linked with the lake water chemistry; (2) The second method forgets about chemical kinetics, degassing models and dynamics of phreatic eruptions, and sticks to the classical principle in geology of "the past is the key for the future". How did lake chemistry parameters vary during the various stages of unrest and eruption, on a purely mathematical basis? Can we recognise patterns in the numerical values related to the changes in volcanic activity? Water chemistry only as a monitoring tool for extremely dynamic and erupting crater lake systems, is inefficient in revealing short-term precursors for single phreatic eruptions, within the current perspective of the residence time dependent monitoring time window. The monitoring rules established since decades based only on water chemistry have thus somehow become obsolete and need revision.

  12. Prognostic models based on patient snapshots and time windows: Predicting disease progression to assisted ventilation in Amyotrophic Lateral Sclerosis.

    Science.gov (United States)

    Carreiro, André V; Amaral, Pedro M T; Pinto, Susana; Tomás, Pedro; de Carvalho, Mamede; Madeira, Sara C

    2015-12-01

    Amyotrophic Lateral Sclerosis (ALS) is a devastating disease and the most common neurodegenerative disorder of young adults. ALS patients present a rapidly progressive motor weakness. This usually leads to death in a few years by respiratory failure. The correct prediction of respiratory insufficiency is thus key for patient management. In this context, we propose an innovative approach for prognostic prediction based on patient snapshots and time windows. We first cluster temporally-related tests to obtain snapshots of the patient's condition at a given time (patient snapshots). Then we use the snapshots to predict the probability of an ALS patient to require assisted ventilation after k days from the time of clinical evaluation (time window). This probability is based on the patient's current condition, evaluated using clinical features, including functional impairment assessments and a complete set of respiratory tests. The prognostic models include three temporal windows allowing to perform short, medium and long term prognosis regarding progression to assisted ventilation. Experimental results show an area under the receiver operating characteristics curve (AUC) in the test set of approximately 79% for time windows of 90, 180 and 365 days. Creating patient snapshots using hierarchical clustering with constraints outperforms the state of the art, and the proposed prognostic model becomes the first non population-based approach for prognostic prediction in ALS. The results are promising and should enhance the current clinical practice, largely supported by non-standardized tests and clinicians' experience. Copyright © 2015 Elsevier Inc. All rights reserved.

  13. The Manpower Allocation Problem with Time Windows and Job-Teaming Constraints: A Branch-and-Price Approach

    DEFF Research Database (Denmark)

    Hansen, Anders Dohn; Kolind, Esben; Clausen, Jens

    2009-01-01

    In this paper, we consider the Manpower Allocation Problem with Time Windows, Job-Teaming Constraints and a limited number of teams (m-MAPTWTC). Given a set of teams and a set of tasks, the problem is to assign to each team a sequential order of tasks to maximize the total number of assigned tasks...

  14. The Manpower Allocation Problem with Time Windows and Job-Teaming Constraints: A Branch-and-Price Approach - Technical Report

    DEFF Research Database (Denmark)

    Hansen, Anders Dohn; Kolind, Esben; Clausen, Jens

    In this paper, we consider the Manpower Allocation Problem with Time Windows, Job-Teaming Constraints and a limited number of teams (m-MAPTWTC). Given a set of teams and a set of tasks, the problem is to assign to each team a sequential order of tasks to maximize the total number of assigned tasks...

  15. A well-scalable metaheuristic for the fleet size and mix vehicle routing problem with time windows

    NARCIS (Netherlands)

    Bräysy, Olli; Porkka, Pasi P.; Dullaert, Wout; Repoussis, Panagiotis P.; Tarantilis, Christos D.

    This paper presents an efficient and well-scalable metaheuristic for fleet size and mix vehicle routing with time windows. The suggested solution method combines the strengths of well-known threshold accepting and guided local search metaheuristics to guide a set of four local search heuristics. The

  16. Time Window Is Important for Adenosine Preventing Cold-induced Injury to the Endothelium.

    Science.gov (United States)

    Li, Yan; Hu, Xiao-Xia; Fu, Li; Chen, Jing; Lu, Li-He; Liu, Xiang; Xu, Zhe; Zhou, Li; Wang, Zhi-Ping; Zhang, Xi; Ou, Zhi-Jun; Ou, Jing-Song

    2017-06-01

    Cold cardioplegia is used to induce heart arrest during cardiac surgery. However, endothelial function may be compromised after this procedure. Accordingly, interventions such as adenosine, that mimic the effects of preconditioning, may minimize endothelial injury. Herein, we investigated whether adenosine prevents cold-induced injury to the endothelium. Cultured human cardiac microvascular endothelial cells were treated with adenosine for different durations. Phosphorylation and expression of endothelial nitric oxide synthase (eNOS), p38MAPK, ERK1/2, and p70S6K6 were measured along with nitric oxide (NO) production using diaminofluorescein-2 diacetate (DAF-2DA) probe. Cold-induced injury by hypothermia to 4°C for 45 minutes to mimic conditions of cold cardioplegia during open heart surgery was induced in human cardiac microvascular endothelial cells. Under basal conditions, adenosine stimulated NO production, eNOS phosphorylation at serine 1177 from 5 minutes to 4 hours and inhibited eNOS phosphorylation at threonine 495 from 5 minutes to 6 hours, but increased phosphorylation of ERK1/2, p38MAPK, and p70S6K only after exposure for 5 minutes. Cold-induced injury inhibited NO production and the phosphorylation of the different enzymes. Importantly, adenosine prevented these effects of hypothermic injury. Our data demonstrated that adenosine prevents hypothermic injury to the endothelium by activating ERK1/2, eNOS, p70S6K, and p38MAPK signaling pathways at early time points. These findings also indicated that 5 minutes after administration of adenosine or release of adenosine is an important time window for cardioprotection during cardiac surgery.

  17. Cerebellar potentiation and learning a whisker-based object localization task with a time response window.

    Science.gov (United States)

    Rahmati, Negah; Owens, Cullen B; Bosman, Laurens W J; Spanke, Jochen K; Lindeman, Sander; Gong, Wei; Potters, Jan-Willem; Romano, Vincenzo; Voges, Kai; Moscato, Letizia; Koekkoek, Sebastiaan K E; Negrello, Mario; De Zeeuw, Chris I

    2014-01-29

    Whisker-based object localization requires activation and plasticity of somatosensory and motor cortex. These parts of the cerebral cortex receive strong projections from the cerebellum via the thalamus, but it is unclear whether and to what extent cerebellar processing may contribute to such a sensorimotor task. Here, we subjected knock-out mice, which suffer from impaired intrinsic plasticity in their Purkinje cells and long-term potentiation at their parallel fiber-to-Purkinje cell synapses (L7-PP2B), to an object localization task with a time response window (RW). Water-deprived animals had to learn to localize an object with their whiskers, and based upon this location they were trained to lick within a particular period ("go" trial) or refrain from licking ("no-go" trial). L7-PP2B mice were not ataxic and showed proper basic motor performance during whisking and licking, but were severely impaired in learning this task compared with wild-type littermates. Significantly fewer L7-PP2B mice were able to learn the task at long RWs. Those L7-PP2B mice that eventually learned the task made unstable progress, were significantly slower in learning, and showed deficiencies in temporal tuning. These differences became greater as the RW became narrower. Trained wild-type mice, but not L7-PP2B mice, showed a net increase in simple spikes and complex spikes of their Purkinje cells during the task. We conclude that cerebellar processing, and potentiation in particular, can contribute to learning a whisker-based object localization task when timing is relevant. This study points toward a relevant role of cerebellum-cerebrum interaction in a sophisticated cognitive task requiring strict temporal processing.

  18. Continuous monitoring of distributed data streams over a time-based sliding window

    DEFF Research Database (Denmark)

    Chan, Ho-Leung; Lam, Tak-Wah; Lee, Lap Kei

    2012-01-01

    statistics of all streams within a given error bound. This paper presents communication-efficient algorithms for three classical statistics, namely, basic counting, frequent items and quantiles. The worst-case communication cost over a window is O(k ε logεN k ) bits for basic counting, O(k ε logN k ) words...... for frequent items and O(k ε 2 logN k ) words for quantiles, where k is the number of distributed data streams, N is the total number of items in the streams that arrive or expire in the window, and ε

  19. The impact of skin decontamination on the time window for effective treatment of percutaneous VX exposure.

    Science.gov (United States)

    Joosen, M J A; van den Berg, R M; de Jong, A L; van der Schans, M J; Noort, D; Langenberg, J P

    2017-04-01

    The main goal of the present study was to obtain insight into depot formation and penetration following percutaneous VX poisoning, in order to identify an appropriate decontamination window that can enhance or support medical countermeasures. The study was executed in two phases, using the hairless guinea pig as an animal model. In the first phase the effect of various decontamination regimens on levels of free VX in skin and plasma were studied as well as on blood cholinesterase levels. Animals were exposed to 0.5 mg/kg VX and were not decontaminated (control), decontaminated with RSDL once at 15 or 90 min after exposure or three times at 15, 25 and 35 (10-min interval) or 15, 45 and 75 min after exposure (30-min interval). There was no significant effect of any of the decontamination regimens on the 6-h survival rate of the animals. However, all animals that had been decontaminated 15 min after exposure, showed a survival rate of more than 90%, compared to 50-60% in animals that were not decontaminated or decontaminated at 90 min after exposure. In the second phase of the study, hairless guinea pigs were exposed to 1 mg/kg VX on the shoulder, followed either by decontamination with RSDL (10 min interval), conventional treatment on indication of clinical signs or a combination thereof. It appeared that a thorough, repeated decontamination alone could not save the majority of the animals. A 100% survival rate was observed in the group that received a combination of decontamination and treatment. In conclusion, the effects of VX exposure could be influenced by various RSDL decontamination regimens. The results in freely moving animals showed that skin decontamination, although not fully effective in removing all VX from the skin and skin depot is crucial to support pharmacological intervention. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  20. The impact of skin decontamination on the time window for effective treatment of percutaneous VX exposure

    NARCIS (Netherlands)

    Joosen, M.J.A.; Berg, R.M. van den; Jong, A.L. de; Schans, M.J. van der; Noort, D.; Langenberg, J.P.

    2017-01-01

    The main goal of the present study was to obtain insight into depot formation and penetration following percutaneous VX poisoning, in order to identify an appropriate decontamination window that can enhance or support medical countermeasures. The study was executed in two phases, using the hairless

  1. Windows 10 for dummies

    CERN Document Server

    Rathbone, Andy

    2015-01-01

    The fast and easy way to get up and running with Windows 10 Windows 10 For Dummies covers the latest version of Windows and gets you up and running with the changes and new features you'll find in this updated operating system. Packed with time-saving tips to help you get the most out of the software, this helpful Windows 10 guide shows you how to manage Windows tasks like navigating the interface with a mouse or touchscreen, connecting to the web, and troubleshooting problems and making quick fixes. Assuming no prior knowledge of the software, Windows 10 For Dummies addresses the updates to

  2. Therapeutic time window and underlying therapeutic mechanism of breviscapine injection against cerebral ischemia/reperfusion injury in rats.

    Science.gov (United States)

    Guo, Chao; Zhu, Yanrong; Weng, Yan; Wang, Shiquan; Guan, Yue; Wei, Guo; Yin, Ying; Xi, Miaomaio; Wen, Aidong

    2014-01-01

    Breviscapine injection is a Chinese herbal medicine standardized product extracted from Erigeron breviscapus (Vant.) Hand.-Mazz. It has been widely used for treating cardiovascular and cerebrovascular diseases. However, the therapeutic time window and the action mechanism of breviscapine are still unclear. The present study was designed to investigate the therapeutic time window and underlying therapeutic mechanism of breviscapine injection against cerebral ischemic/reperfusion injury. Sprague-Dawley rats were subjected to middle cerebral artery occlusion for 2h followed by 24h of reperfusion. Experiment part 1 was used to investigate the therapeutic time window of breviscapine. Rats were injected intravenously with 50mg/kg breviscapine at different time-points of reperfusion. After 24h of reperfusion, neurologic score, infarct volume, brain water content and serum level of neuron specific enolase (NSE) were measured in a masked fashion. Part 2 was used to explore the therapeutic mechanism of breviscapine. 4-Hydroxy-2-nonenal (4-HNE), 8-hydroxyl-2'- deoxyguanosine (8-OHdG) and the antioxidant capacity of ischemia cortex were measured by ELISA and ferric-reducing antioxidant power (FRAP) assay, respectively. Immunofluorescence and western blot analysis were used to analyze the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1). Part 1: breviscapine injection significantly ameliorated neurologic deficit, reduced infarct volume and water content, and suppressed the levels of NSE in a time-dependent manner. Part 2: breviscapine inhibited the increased levels of 4-HNE and 8-OHdG, and enhanced the antioxidant capacity of cortex tissue. Moreover, breviscapine obviously raised the expression of Nrf2 and HO-1 proteins after 24h of reperfusion. The therapeutic time window of breviscapine injection for cerebral ischemia/reperfusion injury seemed to be within 5h after reperfusion. By up-regulating the expression of Nrf2/HO-1 pathway

  3. Ultrafast time measurements by time-correlated single photon counting coupled with superconducting single photon detector

    Energy Technology Data Exchange (ETDEWEB)

    Shcheslavskiy, V., E-mail: vis@becker-hickl.de; Becker, W. [Becker & Hickl GmbH, Nahmitzer Damm 30, 12277 Berlin (Germany); Morozov, P.; Divochiy, A. [Scontel, Rossolimo St., 5/22-1, Moscow 119021 (Russian Federation); Vakhtomin, Yu. [Scontel, Rossolimo St., 5/22-1, Moscow 119021 (Russian Federation); Moscow State Pedagogical University, 1/1 M. Pirogovskaya St., Moscow 119991 (Russian Federation); Smirnov, K. [Scontel, Rossolimo St., 5/22-1, Moscow 119021 (Russian Federation); Moscow State Pedagogical University, 1/1 M. Pirogovskaya St., Moscow 119991 (Russian Federation); National Research University Higher School of Economics, 20 Myasnitskaya St., Moscow 101000 (Russian Federation)

    2016-05-15

    Time resolution is one of the main characteristics of the single photon detectors besides quantum efficiency and dark count rate. We demonstrate here an ultrafast time-correlated single photon counting (TCSPC) setup consisting of a newly developed single photon counting board SPC-150NX and a superconducting NbN single photon detector with a sensitive area of 7 × 7 μm. The combination delivers a record instrument response function with a full width at half maximum of 17.8 ps and system quantum efficiency ∼15% at wavelength of 1560 nm. A calculation of the root mean square value of the timing jitter for channels with counts more than 1% of the peak value yielded about 7.6 ps. The setup has also good timing stability of the detector–TCSPC board.

  4. Strategic Windows

    DEFF Research Database (Denmark)

    Risberg, Annette; King, David R.; Meglio, Olimpia

    We examine the importance of speed and timing in acquisitions with a framework that identifies management considerations for three interrelated acquisition phases (selection, deal closure and integration) from an acquiring firm’s perspective. Using a process perspective, we pinpoint items within...... acquisition phases that relate to speed. In particular, we present the idea of time-bounded strategic windows in acquisitions consistent with the notion of kairòs, where opportunities appear and must be pursued at the right time for success to occur....

  5. A comparative study between a simplified Kalman filter and Sliding Window Averaging for single trial dynamical estimation of event-related potentials

    DEFF Research Database (Denmark)

    Vedel-Larsen, Esben; Fuglø, Jacob; Channir, Fouad

    2010-01-01

    , are variable and depend on cognitive function. This study compares the performance of a simplified Kalman filter with Sliding Window Averaging in tracking dynamical changes in single trial P300. The comparison is performed on simulated P300 data with added background noise consisting of both simulated and real...

  6. Embryonic pig liver, pancreas, and lung as a source for transplantation: Optimal organogenesis without teratoma depends on distinct time windows

    OpenAIRE

    Eventov-Friedman, Smadar; Katchman, Helena; Shezen, Elias; Aronovich, Anna; Tchorsh, Dalit; Dekel, Benjamin; Freud, Enrique; Reisner, Yair

    2005-01-01

    Pig embryonic tissues represent an attractive option for organ transplantation. However, the achievement of optimal organogenesis after transplantation, namely, maximal organ growth and function without teratoma development, represents a major challenge. In this study, we determined distinct gestational time windows for the growth of pig embryonic liver, pancreas, and lung precursors. Transplantation of embryonic-tissue precursors at various gestational ages [from E (embryonic day) 21 to E100...

  7. Optimal scanning time window for 18F-FP-(+)-DTBZ (18F-AV-133) summed uptake measurements

    International Nuclear Information System (INIS)

    Lin, Kun-Ju; Lin, Wey-Yil; Hsieh, Chia-Ju; Weng, Yi-Hsin; Wey, Shiaw-Pyng; Lu, Chin-Song; Skovronsky, Daniel; Yen, Tzu-Chen; Chang, Chee-Jen; Kung, Mei-Ping

    2011-01-01

    18 F-9-fluoropropyl-(+)-dihydrotetrabenazine ( 18 F-AV-133) is a novel positron emission tomography tracer for imaging the vesicular monoamine transporter II in dopaminergic neuron degeneration, which might be indicative for Parkinson's disease (PD) and other parkinsonism. Studies were performed to optimize the imaging time window for calculating standardized uptake value ratio (SUVR) with correlation to distribution volume ratio (DVR) and in differentiating PD from normal controls (NCs). Methods: Thirteen 18 F-AV-133 positron emission tomography studies were conducted on four NCs (age, 62.3±4.9 years) and nine PD patients (age, 60.8±6.0 years) with Hoehn and Yahr stages 2 to 3. Dynamic images were acquired within 180 min (0–30, 50–140 and 160–180 min) and were rearranged into 14 of 10-min scans. The contralateral striatum was defined as the opposite striatum to the predominantly affected limbs. Volumes of interest (VOIs) of bilateral putamen, caudate nuclei and occipital cortex (OC; as the reference region) were delineated from individual magnetic resonance imaging. SUVRs of striatum to OC were computed from 14 dynamic image sets. The DVRs were computed from Logan graphic analysis by using OC as the input. The performance of SUVR was evaluated based on the correlation of SUVR at each time window to DVR, as well as the Cohen effect size (group mean SUVR difference between PD and NC/standard deviation). Results: 18 F-AV-133 uptake decreased in PD subjects at bilateral striatum especially at contralateral side with posterior putamen predominant as compared with NC. Consistent higher correlations of SUVRs to DVR for all VOIs were observed at later time window and reached to its maximal value of 0.9917 at 90–100 min. The group mean SUVR differences between NC and PD subjects increased and reached relatively stable values after 90 min. The effect sizes for all VOIs were stable across different time window and with the largest value around 90∼120 min

  8. A comparative study between a simplified Kalman filter and Sliding Window Averaging for single trial dynamical estimation of event-related potentials

    DEFF Research Database (Denmark)

    Vedel-Larsen, Esben; Fuglø, Jacob; Channir, Fouad

    2010-01-01

    , are variable and depend on cognitive function. This study compares the performance of a simplified Kalman filter with Sliding Window Averaging in tracking dynamical changes in single trial P300. The comparison is performed on simulated P300 data with added background noise consisting of both simulated and real...... background EEG in various input signal to noise ratios. While both methods can be applied to track dynamical changes, the simplified Kalman filter has an advantage over the Sliding Window Averaging, most notable in a better noise suppression when both are optimized for faster changing latency and amplitude...

  9. Accuracy of rate coding: When shorter time window and higher spontaneous activity help

    Czech Academy of Sciences Publication Activity Database

    Leváková, Marie; Tamborrino, M.; Košťál, Lubomír; Lánský, Petr

    2017-01-01

    Roč. 95, č. 2 (2017), č. článku 022310. ISSN 2470-0045 R&D Projects: GA ČR(CZ) GA15-08066S; GA MŠk(CZ) 7AMB17AT048 Institutional support: RVO:67985823 Keywords : rate coding * observation window * spontaneous activity * Fisher information * perfect integrate- and -fire model * Wiener process Subject RIV: BB - Applied Statistics, Operational Research OBOR OECD: Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology Impact factor: 2.366, year: 2016

  10. Strategies of statistical windows in PET image reconstruction to improve the user’s real time experience

    Science.gov (United States)

    Moliner, L.; Correcher, C.; Gimenez-Alventosa, V.; Ilisie, V.; Alvarez, J.; Sanchez, S.; Rodríguez-Alvarez, M. J.

    2017-11-01

    Nowadays, with the increase of the computational power of modern computers together with the state-of-the-art reconstruction algorithms, it is possible to obtain Positron Emission Tomography (PET) images in practically real time. These facts open the door to new applications such as radio-pharmaceuticals tracking inside the body or the use of PET for image-guided procedures, such as biopsy interventions, among others. This work is a proof of concept that aims to improve the user experience with real time PET images. Fixed, incremental, overlapping, sliding and hybrid windows are the different statistical combinations of data blocks used to generate intermediate images in order to follow the path of the activity in the Field Of View (FOV). To evaluate these different combinations, a point source is placed in a dedicated breast PET device and moved along the FOV. These acquisitions are reconstructed according to the different statistical windows, resulting in a smoother transition of positions for the image reconstructions that use the sliding and hybrid window.

  11. Windows Azure

    CERN Document Server

    Johnson, Bruce; Chambers, James; Garber, Danny; Malik, Jamal; Fazio, Adam

    2013-01-01

    A collection of five must-have Azure titles, from some of the biggest names in the field Available individually, but at a discounted rate for the collection, this bundle of five e-books covers key developer and IT topics of Windows Azure, including ASP.NET, mobile services, web sites, data storage, and the hybrid cloud. A host of Microsoft employees and MPVs come together to cover the biggest challenges that professionals face when working with Windows Azure. The e-books included are as follows: Windows Azure and ASP.NET MVC MigrationWindows Azure Mobile ServicesWindows Azure Web SitesWindows

  12. Characteristics of single- and dual-photopeak energy window acquisitions with thallium-201 IQ-SPECT/CT system.

    Science.gov (United States)

    Shibutani, Takayuki; Onoguchi, Masahisa; Yoneyama, Hiroto; Konishi, Takahiro; Matsuo, Shinro; Nakajima, Kenichi; Kinuya, Seigo

    2017-08-01

    Although dual-energy (DE) acquisition with conventional 201 Tl myocardial perfusion SPECT has several advantages such as improved attenuation of the inferior wall and increased acquisition counts, the characteristics of IQ-SPECT have not been fully evaluated. We evaluate the difference of characteristics between single-energy (SE) and dual-energy (DE) imaging using 201 Tl myocardial IQ-SPECT. Two myocardial phantoms were created simulating normal myocardium and infarction of the inferior wall. Energy windows were set at 70 keV ± 10% for SE, and an additional 167 keV ± 7.5% for DE. SPECT images were reconstructed using the ordered subset conjugates gradient minimizer (OSCGM) method. We visually and quantitatively compared short-axis images of correction for no (NC), for attenuation (AC) or for both AC and scatter (ACSC) images. The average counts of SE and DE projection data were 17.5 and 20.3 counts/pixel, respectively. The DE data increased acquisition counts by approximately 16% compared with the SE data. The average visual score of normal myocardium did not differ significantly between the SE and DE images. However, the DE image of defective myocardium showed a significantly lower score in AC than SE images. The % uptake values of DE image with both NC and AC were significantly higher than those of SE images. The DE images of the inferior defective areas (segments 4 and 10) showed approximately 5-10% higher uptake compared with the SE images. The DE image with NC improved attenuation of the inferior wall. However, DE image with AC showed low defect detectability. Thus, AC should be used with SE rather than DE. Furthermore, while the SE image with ACSC can be used to detect perfusion defects, it must be interpreted carefully including the possibility of artificial inhomogeneity even in the normal myocardium.

  13. Dynamic species classification of microorganisms across time, abiotic and biotic environments-A sliding window approach.

    Directory of Open Access Journals (Sweden)

    Frank Pennekamp

    Full Text Available The development of video-based monitoring methods allows for rapid, dynamic and accurate monitoring of individuals or communities, compared to slower traditional methods, with far reaching ecological and evolutionary applications. Large amounts of data are generated using video-based methods, which can be effectively processed using machine learning (ML algorithms into meaningful ecological information. ML uses user defined classes (e.g. species, derived from a subset (i.e. training data of video-observed quantitative features (e.g. phenotypic variation, to infer classes in subsequent observations. However, phenotypic variation often changes due to environmental conditions, which may lead to poor classification, if environmentally induced variation in phenotypes is not accounted for. Here we describe a framework for classifying species under changing environmental conditions based on the random forest classification. A sliding window approach was developed that restricts temporal and environmentally conditions to improve the classification. We tested our approach by applying the classification framework to experimental data. The experiment used a set of six ciliate species to monitor changes in community structure and behavior over hundreds of generations, in dozens of species combinations and across a temperature gradient. Differences in biotic and abiotic conditions caused simplistic classification approaches to be unsuccessful. In contrast, the sliding window approach allowed classification to be highly successful, as phenotypic differences driven by environmental change, could be captured by the classifier. Importantly, classification using the random forest algorithm showed comparable success when validated against traditional, slower, manual identification. Our framework allows for reliable classification in dynamic environments, and may help to improve strategies for long-term monitoring of species in changing environments. Our

  14. Dynamic species classification of microorganisms across time, abiotic and biotic environments-A sliding window approach.

    Science.gov (United States)

    Pennekamp, Frank; Griffiths, Jason I; Fronhofer, Emanuel A; Garnier, Aurélie; Seymour, Mathew; Altermatt, Florian; Petchey, Owen L

    2017-01-01

    The development of video-based monitoring methods allows for rapid, dynamic and accurate monitoring of individuals or communities, compared to slower traditional methods, with far reaching ecological and evolutionary applications. Large amounts of data are generated using video-based methods, which can be effectively processed using machine learning (ML) algorithms into meaningful ecological information. ML uses user defined classes (e.g. species), derived from a subset (i.e. training data) of video-observed quantitative features (e.g. phenotypic variation), to infer classes in subsequent observations. However, phenotypic variation often changes due to environmental conditions, which may lead to poor classification, if environmentally induced variation in phenotypes is not accounted for. Here we describe a framework for classifying species under changing environmental conditions based on the random forest classification. A sliding window approach was developed that restricts temporal and environmentally conditions to improve the classification. We tested our approach by applying the classification framework to experimental data. The experiment used a set of six ciliate species to monitor changes in community structure and behavior over hundreds of generations, in dozens of species combinations and across a temperature gradient. Differences in biotic and abiotic conditions caused simplistic classification approaches to be unsuccessful. In contrast, the sliding window approach allowed classification to be highly successful, as phenotypic differences driven by environmental change, could be captured by the classifier. Importantly, classification using the random forest algorithm showed comparable success when validated against traditional, slower, manual identification. Our framework allows for reliable classification in dynamic environments, and may help to improve strategies for long-term monitoring of species in changing environments. Our classification pipeline

  15. Advanced energy efficient windows

    DEFF Research Database (Denmark)

    Thomsen, Kirsten Engelund

    2007-01-01

    energy savings. In terms of energy, windows occupy a special position compared with other thermal envelope structures due to their many functions: 1) windows let daylight into the building and provide occupants with visual contact with their surroundings 2) windows protect against the outdoor climate 3......) windows transmit solar energy that may contribute to a reduction of energy consumption, but which may also lead to unpleasant overheating. In the following paragraphs the current use of windows is reviewed with an emphasis on energy, while special products like solar protection glazing and security......Windows should be paid special attention as they contribute a significant part of the total heat-loss coefficient of the building. Contrary to other parts of the thermal envelope the windows are not only heat loosers, but may gain heat in the day-time. Therefore there are possibilities for large...

  16. An Analysis of Peer-Reviewed Scores and Impact Factors with Different Citation Time Windows: A Case Study of 28 Ophthalmologic Journals.

    Science.gov (United States)

    Liu, Xue-Li; Gai, Shuang-Shuang; Zhang, Shi-Le; Wang, Pu

    2015-01-01

    An important attribute of the traditional impact factor was the controversial 2-year citation window. So far, several scholars have proposed using different citation time windows for evaluating journals. However, there is no confirmation whether a longer citation time window would be better. How did the journal evaluation effects of 3IF, 4IF, and 6IF comparing with 2IF and 5IF? In order to understand these questions, we made a comparative study of impact factors with different citation time windows with the peer-reviewed scores of ophthalmologic journals indexed by Science Citation Index Expanded (SCIE) database. The peer-reviewed scores of 28 ophthalmologic journals were obtained through a self-designed survey questionnaire. Impact factors with different citation time windows (including 2IF, 3IF, 4IF, 5IF, and 6IF) of 28 ophthalmologic journals were computed and compared in accordance with each impact factor's definition and formula, using the citation analysis function of the Web of Science (WoS) database. An analysis of the correlation between impact factors with different citation time windows and peer-reviewed scores was carried out. Although impact factor values with different citation time windows were different, there was a high level of correlation between them when it came to evaluating journals. In the current study, for ophthalmologic journals' impact factors with different time windows in 2013, 3IF and 4IF seemed the ideal ranges for comparison, when assessed in relation to peer-reviewed scores. In addition, the 3-year and 4-year windows were quite consistent with the cited peak age of documents published by ophthalmologic journals. Our study is based on ophthalmology journals and we only analyze the impact factors with different citation time window in 2013, so it has yet to be ascertained whether other disciplines (especially those with a later cited peak) or other years would follow the same or similar patterns. We designed the survey questionnaire

  17. Inventions on Displaying and Resizing Windows

    OpenAIRE

    Mishra, Umakant

    2014-01-01

    Windows are used quite frequently in a GUI environment. The greatest advantage of using windows is that each window creates a virtual screen space. Hence, although the physical screen space is limited to a few inches, use of windows can create unlimited screen space to display innumerable items. The use of windows facilitates the user to open and interact with multiple programs or documents simultaneously in different windows. Sometimes a single program may also open multiple windows to displ...

  18. Parenthetical Windows

    DEFF Research Database (Denmark)

    Lemi, Esther; Triantafyllidis, Georgios

    2016-01-01

    artificial from natural stimuli and detects common and individual needs by measuring heart pulse and body temperature. The focal point here is light and how light affects human perception while at the same time the perception of sound and how gesture can provide the best possible cognition of actual needs...... light is a form that adapts natures’ properties and modifies the artificial environment as a stage direction, implying at the same time mood and modifying it in collaboration with sound. Having evaluated how this affects the body and human perception in this particular time that we experience nowadays......Parenthetical Window is a project that engages scientific research in human perception providing a platform for users to experience their own limits and needs in their individual circadian rhythm. The presentation focuses on a case study in a community of dancers where the individual needs in light...

  19. Time series analytics using sliding window metaheuristic optimization-based machine learning system for identifying building energy consumption patterns

    International Nuclear Information System (INIS)

    Chou, Jui-Sheng; Ngo, Ngoc-Tri

    2016-01-01

    Highlights: • This study develops a novel time-series sliding window forecast system. • The system integrates metaheuristics, machine learning and time-series models. • Site experiment of smart grid infrastructure is installed to retrieve real-time data. • The proposed system accurately predicts energy consumption in residential buildings. • The forecasting system can help users minimize their electricity usage. - Abstract: Smart grids are a promising solution to the rapidly growing power demand because they can considerably increase building energy efficiency. This study developed a novel time-series sliding window metaheuristic optimization-based machine learning system for predicting real-time building energy consumption data collected by a smart grid. The proposed system integrates a seasonal autoregressive integrated moving average (SARIMA) model and metaheuristic firefly algorithm-based least squares support vector regression (MetaFA-LSSVR) model. Specifically, the proposed system fits the SARIMA model to linear data components in the first stage, and the MetaFA-LSSVR model captures nonlinear data components in the second stage. Real-time data retrieved from an experimental smart grid installed in a building were used to evaluate the efficacy and effectiveness of the proposed system. A k-week sliding window approach is proposed for employing historical data as input for the novel time-series forecasting system. The prediction system yielded high and reliable accuracy rates in 1-day-ahead predictions of building energy consumption, with a total error rate of 1.181% and mean absolute error of 0.026 kW h. Notably, the system demonstrates an improved accuracy rate in the range of 36.8–113.2% relative to those of the linear forecasting model (i.e., SARIMA) and nonlinear forecasting models (i.e., LSSVR and MetaFA-LSSVR). Therefore, end users can further apply the forecasted information to enhance efficiency of energy usage in their buildings, especially

  20. Neural basis of the time window for subjective motor-auditory integration

    Directory of Open Access Journals (Sweden)

    Koichi eToida

    2016-01-01

    Full Text Available Temporal contiguity between an action and corresponding auditory feedback is crucial to the perception of self-generated sound. However, the neural mechanisms underlying motor–auditory temporal integration are unclear. Here, we conducted four experiments with an oddball paradigm to examine the specific event-related potentials (ERPs elicited by delayed auditory feedback for a self-generated action. The first experiment confirmed that a pitch-deviant auditory stimulus elicits mismatch negativity (MMN and P300, both when it is generated passively and by the participant’s action. In our second and third experiments, we investigated the ERP components elicited by delayed auditory feedback of for a self-generated action. We found that delayed auditory feedback elicited an enhancement of P2 (enhanced-P2 and a N300 component, which were apparently different from the MMN and P300 components observed in the first experiment. We further investigated the sensitivity of the enhanced-P2 and N300 to delay length in our fourth experiment. Strikingly, the amplitude of the N300 increased as a function of the delay length. Additionally, the N300 amplitude was significantly correlated with the conscious detection of the delay (the 50% detection point was around 200 ms, and hence reduction in the feeling of authorship of the sound (the sense of agency. In contrast, the enhanced-P2 was most prominent in short-delay (≤ 200 ms conditions and diminished in long-delay conditions. Our results suggest that different neural mechanisms are employed for the processing of temporally-deviant and pitch-deviant auditory feedback. Additionally, the temporal window for subjective motor–auditory integration is likely about 200 ms, as indicated by these auditory ERP components.

  1. Vehicle Routing Problem with Soft Time Windows Based on Improved Genetic Algorithm for Fruits and Vegetables Distribution

    Directory of Open Access Journals (Sweden)

    Peiqing Li

    2015-01-01

    Full Text Available Fresh fruits and vegetables, perishable by nature, are subject to additional deterioration and bruising in the distribution process due to vibration and shock caused by road irregularities. A nonlinear mathematical model was developed that considered not only the vehicle routing problem with time windows but also the effect of road irregularities on the bruising of fresh fruits and vegetables. The main objective of this work was to obtain the optimal distribution routes for fresh fruits and vegetables considering different road classes with the least amount of logistics costs. An improved genetic algorithm was used to solve the problem. A fruit delivery route among the 13 cities in Jiangsu Province was used as a real analysis case. The simulation results showed that the vehicle routing problem with time windows, considering road irregularities and different classes of toll roads, can significantly influence total delivery costs compared with traditional VRP models. The comparison between four models to predict the total cost and actual total cost in distribution showed that the improved genetic algorithm is superior to the Group-based pattern, CW pattern, and O-X type cross pattern.

  2. An Integer Programming Model For Solving Heterogeneous Vehicle Routing Problem With Hard Time Window considering Service Choice

    Science.gov (United States)

    Susilawati, Enny; Mawengkang, Herman; Efendi, Syahril

    2018-01-01

    Generally a Vehicle Routing Problem with time windows (VRPTW) can be defined as a problem to determine the optimal set of routes used by a fleet of vehicles to serve a given set of customers with service time restrictions; the objective is to minimize the total travel cost (related to the travel times or distances) and operational cost (related to the number of vehicles used). In this paper we address a variant of the VRPTW in which the fleet of vehicle is heterogenic due to the different size of demand from customers. The problem, called Heterogeneous VRP (HVRP) also includes service levels. We use integer programming model to describe the problem. A feasible neighbourhood approach is proposed to solve the model.

  3. Cyclic multiple-robot scheduling with time-window constraints using a critical path approach

    NARCIS (Netherlands)

    Alcaide, David; Chu, Chengbin; Kats, Vladimir; Levner, Eugene; Sierksma, Gerard

    2007-01-01

    An automated production system is considered in which several robots are used for transporting parts between workstations following a given route in a carousel mode. The problem is to maximize the throughput rate. Extending previous works treating scheduling problems for a single robot, we consider

  4. Computed Tomography Window Blending: Feasibility in Thoracic Trauma.

    Science.gov (United States)

    Mandell, Jacob C; Wortman, Jeremy R; Rocha, Tatiana C; Folio, Les R; Andriole, Katherine P; Khurana, Bharti

    2018-02-07

    This study aims to demonstrate the feasibility of processing computed tomography (CT) images with a custom window blending algorithm that combines soft-tissue, bone, and lung window settings into a single image; to compare the time for interpretation of chest CT for thoracic trauma with window blending and conventional window settings; and to assess diagnostic performance of both techniques. Adobe Photoshop was scripted to process axial DICOM images from retrospective contrast-enhanced chest CTs performed for trauma with a window-blending algorithm. Two emergency radiologists independently interpreted the axial images from 103 chest CTs with both blended and conventional windows. Interpretation time and diagnostic performance were compared with Wilcoxon signed-rank test and McNemar test, respectively. Agreement with Nexus CT Chest injury severity was assessed with the weighted kappa statistic. A total of 13,295 images were processed without error. Interpretation was faster with window blending, resulting in a 20.3% time saving (P window-blended cases was 82.7%, compared to 81.6% for conventional windows. The specificity of the window-blended cases was 93.1%, compared to 90.5% for conventional windows. All injuries of major clinical significance (per Nexus CT Chest criteria) were correctly identified in all reading sessions, and all negative cases were correctly classified. All readers demonstrated near-perfect agreement with injury severity classification with both window settings. In this pilot study utilizing retrospective data, window blending allows faster preliminary interpretation of axial chest CT performed for trauma, with no significant difference in diagnostic performance compared to conventional window settings. Future studies would be required to assess the utility of window blending in clinical practice. Copyright © 2018 The Association of University Radiologists. All rights reserved.

  5. Fast X-Ray Timing: A Window into the Strong-Field Regime

    Science.gov (United States)

    Strohmayer, Tod

    2010-01-01

    The dynamical time-scales in the vicinity of neutron star surfaces and black hole horizons are in the millisecond range. Over the past decade, timing signatures on such scales, either quasi-periodic oscillations (QPOs) and/or coherent pulsations, have been discovered and studied from both neutron stars and black holes with NASA's Rossi X-ray Timing Explorer, Although theoretical interpretations are still hotly debated, these timing properties almost certainly reflect the dynamics of matter in regions dominated by relativistic gravity. I will survey our current understanding of these timing properties, with a focus on how they might he used as probes of fundamental physics.

  6. A new supply chain management method with one-way time window: A hybrid PSO-SA approach

    Directory of Open Access Journals (Sweden)

    Reza Tavakkoli-Moghaddam

    2012-01-01

    Full Text Available In this paper, we study a supply chain problem where a whole seller/producer distributes goods among different retailers. The proposed model of this paper is formulated as a more general and realistic form of traditional vehicle routing problem (VRP. The main advantages of the new proposed model are twofold. First, the time window does not consider any lower bound and second, it treats setup time as separate cost components. The resulted problem is solved using a hybrid of particle swarm optimization and simulated annealing (PSO-SA. The results are compared with other hybrid method, which is a combination of Ant colony and Tabu search. We use some well-known benchmark problems to compare the results of our proposed model with other method. The preliminary results indicate that the proposed model of this paper performs reasonably well.

  7. Windows Powershell Pocket Reference

    CERN Document Server

    Holmes, Lee

    2009-01-01

    This portable reference to Windows PowerShell summarizes both the command shell and scripting language, and provides a concise reference to the major tasks that make PowerShell so successful. Written by Microsoft PowerShell team member Lee Holmes, and excerpted from his Windows PowerShell Cookbook, Windows PowerShell Pocket Reference offers up-to-date coverage of PowerShell's 1.0 release. It's an ideal on-the-job tool for Windows administrators who don't have time to plow through huge books or search online.

  8. M13 phage-functionalized single-walled carbon nanotubes as nanoprobes for second near-infrared window fluorescence imaging of targeted tumors.

    Science.gov (United States)

    Yi, Hyunjung; Ghosh, Debadyuti; Ham, Moon-Ho; Qi, Jifa; Barone, Paul W; Strano, Michael S; Belcher, Angela M

    2012-03-14

    Second near-infrared (NIR) window light (950-1400 nm) is attractive for in vivo fluorescence imaging due to its deep penetration depth in tissues and low tissue autofluorescence. Here we show genetically engineered multifunctional M13 phage can assemble fluorescent single-walled carbon nanotubes (SWNTs) and ligands for targeted fluorescence imaging of tumors. M13-SWNT probe is detectable in deep tissues even at a low dosage of 2 μg/mL and up to 2.5 cm in tissue-like phantoms. Moreover, targeted probes show specific and up to 4-fold improved uptake in prostate specific membrane antigen positive prostate tumors compared to control nontargeted probes. This M13 phage-based second NIR window fluorescence imaging probe has great potential for specific detection and therapy monitoring of hard-to-detect areas. © 2012 American Chemical Society

  9. Minimum vehicle fleet size under time window constraints at a container terminal

    NARCIS (Netherlands)

    Vis, I.F.A.; de Koster, R.; Savelsbergh, M.W.P.

    2005-01-01

    Products can be transported in containers from one port to another. At a container terminal these containers are transshipped from one mode of transportation to another. Cranes remove containers from a ship and put them at a certain time (i.e., release time) into a buffer area with limited capacity.

  10. Surgery for subacromial impingement syndrome in relation to intensities of occupational mechanical exposures across 10-year exposure time windows.

    Science.gov (United States)

    Dalbøge, Annett; Frost, Poul; Andersen, Johan Hviid; Svendsen, Susanne Wulff

    2018-03-01

    We aimed to identify intensities of occupational mechanical exposures (force, arm elevation and repetition) that do not entail an increased risk of surgery for subacromial impingement syndrome (SIS) even after prolonged durations of exposure. Additionally, we wanted to evaluate if exposure to hand-arm vibration (HAV) is an independent risk factor. We used data from a register-based cohort study of the entire Danish working population (n=2 374 403). During follow-up (2003-2008), 14 118 first-time events of surgery for SIS occurred. For each person, we linked register-based occupational codes (1993-2007) to a general population job exposure matrix to obtain year-by-year exposure intensities on measurement scales for force, upper arm elevation >90° and repetition and expert rated intensities of exposure to HAV. For 10-year exposure time windows, we calculated the duration of exposure at specific intensities above minimal (low, medium and high). We used a logistic regression technique equivalent to discrete survival analysis adjusting for cumulative effects of other mechanical exposures. We found indications of safe exposure intensities for repetition (median angular velocity 90° >2 min/day implied an increased risk reaching ORs of 1.7 and 1.5 after 10 years at low intensities. No associations were found for HAV. We found indications of safe exposure intensities for repetition. Any intensities of force and upper arm elevation >90° above minimal implied an increased risk across 10-year exposure time windows. No independent associations were found for HAV. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  11. UAV Scheduling via the Vehicle Routing Problem with Time Windows (Preprint)

    National Research Council Canada - National Science Library

    Weinstein, Amanda L; Schumacher, Corey

    2007-01-01

    .... Whatever the task, the air vehicles must cooperate by efficiently communicating with each other and optimally assigning each UAV to the appropriate task at the appropriate target and at the appropriate time...

  12. Space-Time Windowing of Angle-Beam Wavefield Data to Characterize Scattering from Defects (Preprint)

    Science.gov (United States)

    2017-10-12

    baseline alignment [4] is helpful to compensate for temporal and spatial misalignment, neither the incident waves nor scattered waves from geometrical...4 mm notch emanating from a 6.35 mm diameter through-hole. As can be seen from Figure 2, the 2nd and 3rd incident shear wave skips interfere with...energy curve need to be time- aligned to the current wavefield before the baseline and current energy curves can be compared; this time alignment corrects

  13. The Luminaire Window

    DEFF Research Database (Denmark)

    Hansen, Ellen Kathrine; Horóczi, Eszter

    2017-01-01

    integrated into the window. A qualitative experiment is carried out by integrating controllable LED in the frame of a façade window in a full-scale mock-up. It is examined how this set-up can support the colour spectrum and intensity of the daylight intake during the transmission time from daylight...

  14. An Adaptive Large Neighborhood Search-based Three-Stage Matheuristic for the Vehicle Routing Problem with Time Windows

    DEFF Research Database (Denmark)

    Christensen, Jonas Mark; Røpke, Stefan

    The Vehicle Routing Problem with Time Windows (VRPTW) consist of determining a set of feasible vehicle routes to deliver goods to a set of customers using a hierarchical objective; first minimising the number of vehicles used and, second, the total driving distance. A three-stage method is proposed...... for the VRPTW. The first stage aims at minimising the number of vehicle used, whereas the second and third phase aims at minimising the travel distance. The first stage maintains an ejection pool with temporarily unserved customers, and tries to insert these customer into the existing solution. If a new...... candidate solution for the minimum number of vehicles is found, a route is removed and the customers from the route is placed in the ejection pool. If the heuristic terminates without finding a new candidate solution where all customers are served, the first stage returns the last found candidate solution...

  15. Human synapses show a wide temporal window for spike-timing-dependent plasticity

    NARCIS (Netherlands)

    Testa-Silva, G.; Verhoog, M.B.; Goriounova, N.A.; Loebel, A.; Hjorth, J.; Baayen, J.C.; de Kock, C.P.J.; Mansvelder, H.D.

    2010-01-01

    Throughout our lifetime, activity-dependent changes in neuronal connection strength enable the brain to refine neural circuits and learn based on experience. Synapses can bi-directionally alter strength and the magnitude and sign depend on the millisecond timing of presynaptic and postsynaptic

  16. Window Stories

    DEFF Research Database (Denmark)

    Hauge, Bettina

    This research project has investigated 17 households in Germany (cities and rural areas). The main aim was to learn about the significance of the window to these people: What they think of their windows, how, when and why they use them in their everyday life, if they have a favorite window and why......, as well as the opposite. The report also includes a special focus on overheating and people’s strategies against this. Knowing about what people appreciate in a window and their actual practices and the reasons for their behaviour may be useful in many different ways, for instance to inform public...... of ethnographic tools that required their involvement, such as making a diary of their heating experiences during a random week in the summer of 2014, taking photos of windows and sending postcards with specific tasks....

  17. Estimation of temporary change of activation areas by moving an analysis time window in fMRI measurement

    Science.gov (United States)

    Fukami, Tadanori; Shimada, Takamasa; Akatsuka, Takao; Ishikawa, Fumito; Saito, Yoichi

    2004-12-01

    In this paper, we propose a method to acquire temporal changes of activations by moving an analysis time window. An advantage of this method is that it can acquire rough changes of activated areas even with the data having low time resolution. We ascertained that activations from our method do not contradict previous reports on the oddball paradigm, thus showing its effectiveness. Eight normal subjects participated in the study, which consisted of a random series of 30 target and 70 nontarget stimuli. We investigated the activated area in three kinds of analysis time sections, from stimulus onset to 5 s after the stimulus (time section A), from 2 to 7 s after (B) and from 4 to 9 s after (C). In time section A, representative activated areas were regions including the left and supplementary motor areas (SMA), and cerebellum. In B, regions including the left motor area and SMA, right parahippocampal gyrus (Broadmann Area (BA) 30), right limbic lobe and cerebellum were activated. In C, bilaterally postcentral gyrus (BA 3,40), right anterior cingulate (ACC, BA 32), left middle frontal gyrus (BA 9) and right parahippocampal gyrus were activated. Most activations were consistent with previous studies.

  18. The window of visibility: A psychological theory of fidelity in time-sampled visual motion displays

    Science.gov (United States)

    Watson, A. B.; Ahumada, A. J., Jr.; Farrell, J. E.

    1983-01-01

    Many visual displays, such as movies and television, rely upon sampling in the time domain. The spatiotemporal frequency spectra for some simple moving images are derived and illustrations of how these spectra are altered by sampling in the time domain are provided. A simple model of the human perceiver which predicts the critical sample rate required to render sampled and continuous moving images indistinguishable is constructed. The rate is shown to depend upon the spatial and temporal acuity of the observer, and upon the velocity and spatial frequency content of the image. Several predictions of this model are tested and confirmed. The model is offered as an explanation of many of the phenomena known as apparent motion. Finally, the implications of the model for computer-generated imagery are discussed.

  19. A Rare Window Into Magmatic Conduit Processes: Time Series Observations From Active Lava Lakes

    Science.gov (United States)

    Lev, E.; Ruprecht, P.; Patrick, M.; Oppenheimer, C.; Peters, N.; Spampinato, L.; Hernandez Perez, P. A.; Unglert, K.; Barreyre, T.

    2015-12-01

    Time-lapse thermal images of the lake surface are used to investigate the circulation and cooling patterns of three lava lakes: Kilauea's Halema'uma'u crater, Mount Erebus, and Nyiragongo. We report results for the time-dependent, two-dimensional velocity and temperature fields of the lake surface. These data sets constrain the locations of flow divergence (upwelling) and convergence (downwelling), the distribution of distinct "plates" and "rifts", the dominant time scales for changes in flow pattern at each lake, and the physical properties of the magma. Upwelling and downwelling locations are strikingly different between the three lakes. Upwelling at Nyiragongo and Erebus occurs dominantly in the interior of the lake, where it is occasionally interrupted by catastrophic downwellings. At Halema'uma'u upwelling and downwelling occur consistently along the perimeter. It remains to be seen whether these differences are dictated merely by the system's geometry or are indicative of intrinsic factors such as melt viscosity, temperature and volatile and crystal content, or of conduit processes such as gas pistoning or slug flow. The availability of high resolution data at Halema'uma'u allows as us to document the evolution of crustal plates and rifts and to investigate the physical properties of the lava and the crust. The physical properties of the lake's surface control lake cooling rates, and thus need to be included in lake circulation and thermal evolution models. We produce time-temperature cooling curves from surface temperature profiles normal to surface rifts and by tracking the cooling of intra-plate bubble bursts. By comparing observations to analytical cooling models, we estimate a porosity of > 80% during the high stand of the lake, slightly higher than estimates of 70% for the upper 120 meters based on gravity data, and close to the porosity of clasts ejected from the lake during recent minor explosions. Furthermore,we find that the number of surface plates

  20. A behavioral window on the mind of the market: an application of the response time paradigm.

    Science.gov (United States)

    Mast, Fred W; Zaltman, Gerald

    2005-11-15

    This article focuses on the role of implicit knowledge consumers have about particular brands, products or names. The major findings of several studies, conducted at the Mind of the Market Laboratory at Harvard Business School, are presented with specific emphasis on studies in which response time measurements were the core method. The results revealed that implicit measures provide a rich understanding of the meaning conveyed by a product or brand. Moreover, there is also considerable evidence that implicit measures may be better than traditional explicit measures as predictors of consumer behavior. We discuss the implications for the study of consumer behavior and the importance of combining several methods including neuroimaging, which has received recent attention by marketers, economists and social scientists.

  1. Impact of Expanding the Prehospital Stroke Bypass Time Window in a Large Geographic Region.

    Science.gov (United States)

    Stiell, Ian G; Clement, Catherine M; Campbell, Kristy; Sharma, Mukul; Socha, Doug; Sivilotti, Marco L A; Jin, Albert; Perry, Jeffrey J; Lumsden, Jim; Martin, Cally; Froats, Mark; Dionne, Richard; Trickett, John

    2017-03-01

    The Ontario Acute Stroke Medical Redirect Paramedic Protocol (ASMRPP) was revised to allow paramedics to bypass to designated stroke centers if total transport time would be stroke symptoms. A total of 1317 basic and advanced life support paramedics, of 9 land services in 10 rural counties and 5 cities, used the Revised ASMRPP to take appropriate patients directly to 6 designated stroke centers. We enrolled 1277 patients with 98.8% paramedic compliance in form completion. Of these, 755 (61.2%) met the redirect criteria and had these characteristics: mean age 72.1 (range 16-101), male 51.1%, mean time scene to hospital 16.7 minutes (range 0-92). Paramedics demonstrated excellent interobserver agreement (κ, 0.94; 95% confidence interval, 0.91-0.96) and 97.9% accuracy in interpretation of the Revised ASMRPP. Prehospital adverse events occurred in 14.7% of patients, but few were life-threatening. Overall, 71.4% of 755 cases had a stroke code activated at the hospital and 23.2% received thrombolysis. For the 189 potential stroke patients picked up in 1 city, the ASMRPP classified thrombolysis administration with sensitivity 100% and specificity 37.3% and a final diagnosis of stroke, with sensitivity 86.1% and specificity 41.9%. In a large urban-rural area with 9 paramedic services, we demonstrated accurate, safe, and effective implementation of the Revised ASMRPP. These revisions will allow more patients with stroke to benefit from early treatment. © 2017 American Heart Association, Inc.

  2. Single Motherhood, Living Arrangements, and Time With Children in Japan.

    Science.gov (United States)

    Raymo, James M; Park, Hyunjoon; Iwasawa, Miho; Zhou, Yanfei

    2014-08-01

    The authors examined relationships between single parenthood and mothers' time with children in Japan. Using data from the 2011 National Survey of Households with Children (N = 1,926), they first demonstrate that time spent with children and the frequency of shared dinners are significantly lower for single mothers than for their married counterparts. For single mothers living alone, less time with children reflects long work hours and work-related stress. Single mothers coresiding with parents spend less time with children and eat dinner together less frequently than either married mothers or their unmarried counterparts not living with parents, net of (grand)parental support, work hours, income, and stress. The findings suggest that rising divorce rates and associated growth in single-mother families may have a detrimental impact on parents' time with children in Japan and that the relatively high prevalence of intergenerational coresidence among single mothers may do little to temper this impact.

  3. EVALUTION OF THE SINGLE INTERCITY FREIGHT TRANSPORTATION WAITING TIME

    Directory of Open Access Journals (Sweden)

    N. Ponomariova

    2015-07-01

    Full Text Available The example of vechicle operation on the pendulum intercity route during single freightages processing is considered. Two approaches to the definition of the single freightage waiting time by the carrier are proposed. These approaches allow to take into account the probability of the single freightage obtaining by the carrier during the different load level of the transport enterprise capacity.

  4. Air transparent soundproof window

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sang-Hoon, E-mail: shkim@mmu.ac.kr [Division of Marine Engineering, Mokpo National Maritime University, Mokpo 530-729, R. O. Korea (Korea, Republic of); Lee, Seong-Hyun [Korea Institute of Machinery and Materials, Yuseong-Gu, Daejeon 305-343, R. O. Korea (Korea, Republic of)

    2014-11-15

    A soundproof window or wall which is transparent to airflow is presented. The design is based on two wave theories: the theory of diffraction and the theory of acoustic metamaterials. It consists of a three-dimensional array of strong diffraction-type resonators with many holes centered on each individual resonator. The negative effective bulk modulus of the resonators produces evanescent wave, and at the same time the air holes with subwavelength diameter existed on the surfaces of the window for macroscopic air ventilation. The acoustic performance levels of two soundproof windows with air holes of 20mm and 50mm diameters were measured. The sound level was reduced by about 30 - 35dB in the frequency range of 400 - 5,000Hz with the 20mm window, and by about 20 - 35dB in the frequency range of 700 - 2,200Hz with the 50mm window. Multi stop-band was created by the multi-layers of the window. The attenuation length or the thickness of the window was limited by background noise. The effectiveness of the soundproof window with airflow was demonstrated by a real installation.

  5. Air transparent soundproof window

    Directory of Open Access Journals (Sweden)

    Sang-Hoon Kim

    2014-11-01

    Full Text Available A soundproof window or wall which is transparent to airflow is presented. The design is based on two wave theories: the theory of diffraction and the theory of acoustic metamaterials. It consists of a three-dimensional array of strong diffraction-type resonators with many holes centered on each individual resonator. The negative effective bulk modulus of the resonators produces evanescent wave, and at the same time the air holes with subwavelength diameter existed on the surfaces of the window for macroscopic air ventilation. The acoustic performance levels of two soundproof windows with air holes of 20mm and 50mm diameters were measured. The sound level was reduced by about 30 - 35dB in the frequency range of 400 - 5,000Hz with the 20mm window, and by about 20 - 35dB in the frequency range of 700 - 2,200Hz with the 50mm window. Multi stop-band was created by the multi-layers of the window. The attenuation length or the thickness of the window was limited by background noise. The effectiveness of the soundproof window with airflow was demonstrated by a real installation.

  6. Interaction between workers during a short time window is required for bacterial symbiont transmission in Acromyrmex leaf-cutting ants.

    Science.gov (United States)

    Marsh, Sarah E; Poulsen, Michael; Pinto-Tomás, Adrián; Currie, Cameron R

    2014-01-01

    Stable associations between partners over time are critical for the evolution of mutualism. Hosts employ a variety of mechanisms to maintain specificity with bacterial associates. Acromyrmex leaf-cutting ants farm a fungal cultivar as their primary nutrient source. These ants also carry a Pseudonocardia Actinobacteria exosymbiont on their bodies that produces antifungal compounds that help inhibit specialized parasites of the ants' fungal garden. Major workers emerge from their pupal cases (eclose) symbiont-free, but exhibit visible Actinobacterial coverage within 14 days post-eclosion. Using subcolony experiments, we investigate exosymbiont transmission within Acromyrmex colonies. We found successful transmission to newly eclosed major workers fostered by major workers with visible Actinobacteria in all cases (100% acquiring, n = 19). In contrast, newly eclosed major workers reared without exosymbiont-carrying major workers did not acquire visible Actinobacteria (0% acquiring, n = 73). We further show that the majority of ants exposed to major workers with exosymbionts within 2 hours of eclosion acquired bacteria (60.7% acquiring, n = 28), while normal acquisition did not occur when exposure occurred later than 2 hours post-eclosion (0% acquiring, n = 18). Our findings show that transmission of exosymbionts to newly eclosed major workers occurs through interactions with exosymbiont-covered workers within a narrow time window after eclosion. This mode of transmission likely helps ensure the defensive function within colonies, as well as specificity and partner fidelity in the ant-bacterium association.

  7. Catch the wave! Time-window sequential analysis of alertness stimulation in individuals with profound intellectual and multiple disabilities.

    Science.gov (United States)

    Munde, V S; Vlaskamp, C; Maes, B; Ruijssenaars, A J J M

    2014-01-01

    While optimally activities are provided at those moments when the individual with profound intellectual and multiple disabilities (PIMD) is 'focused on the environment' or 'alert', detailed information about the impact that the design and timing of the activity has on alertness is lacking. Therefore, the aim of the present study is to shed light on the sequential relationship between different stimuli and alertness levels in individuals with PIMD. Video observations were conducted for 24 participants during one-on-one interactions with a direct support person in multisensory environments. Time-window sequential analyses were conducted for the 120 s following four different stimuli. For the different stimuli, different patterns in terms of alertness became apparent. Following visual stimuli, the alertness levels of the individuals with PIMD changed in waves of about 20 s from 'active alert' to 'passive alert'. While auditory and tactile stimuli led to 'alert' reactions shortly after the stimulation, alertness levels decreased between seconds 20 and 120. Reactions to vestibular stimuli were only visible after 60 s; these were 'active alert' or 'withdrawn'. The results of the present study show that individuals with PIMD show their reactions to stimuli only slightly, so that 'waves' might reflect the optimal alertness pattern for learning and development. Consequently, it is especially important that direct support persons follow and stimulate these individual 'waves' in the activities they provide to their clients. © 2012 John Wiley & Sons Ltd.

  8. On single-time reduction in quantum field theory

    International Nuclear Information System (INIS)

    Arkhipov, A.A.

    1984-01-01

    It is shown, how the causality and spectrality properties in qUantum field theory may help one to carry out a single-time reduction of the Bethe-Salpeter wave fUnction. The single-time reduction technique is not based on any concrete model of the quantum field theory. Axiomatic formulations underline the quantum field theory

  9. A Window-Washing Challenge

    Science.gov (United States)

    Roman, Harry T.

    2010-01-01

    Skyscrapers sure do have a lot of windows, and these windows are cleaned and checked regularly. All this takes time, money, and puts workers at potential risk. Might there be a better way to do it? In this article, the author discusses a window-washing challenge and describes how students can tackle this task, pick up the challenge, and creatively…

  10. Biased random key genetic algorithm with insertion and gender selection for capacitated vehicle routing problem with time windows

    Science.gov (United States)

    Rochman, Auliya Noor; Prasetyo, Hari; Nugroho, Munajat Tri

    2017-06-01

    Vehicle Routing Problem (VRP) often occurs when the manufacturers need to distribute their product to some customers/outlets. The distribution process is typically restricted by the capacity of the vehicle and the working hours at the distributor. This type of VRP is also known as Capacitated Vehicle Routing Problem with Time Windows (CVRPTW). A Biased Random Key Genetic Algorithm (BRKGA) was designed and coded in MATLAB to solve the CVRPTW case of soft drink distribution. The standard BRKGA was then modified by applying chromosome insertion into the initial population and defining chromosome gender for parent undergoing crossover operation. The performance of the established algorithms was then compared to a heuristic procedure for solving a soft drink distribution. Some findings are revealed (1) the total distribution cost of BRKGA with insertion (BRKGA-I) results in a cost saving of 39% compared to the total cost of heuristic method, (2) BRKGA with the gender selection (BRKGA-GS) could further improve the performance of the heuristic method. However, the BRKGA-GS tends to yield worse results compared to that obtained from the standard BRKGA.

  11. Two phase genetic algorithm for vehicle routing and scheduling problem with cross-docking and time windows considering customer satisfaction

    Science.gov (United States)

    Baniamerian, Ali; Bashiri, Mahdi; Zabihi, Fahime

    2018-03-01

    Cross-docking is a new warehousing policy in logistics which is widely used all over the world and attracts many researchers attention to study about in last decade. In the literature, economic aspects has been often studied, while one of the most significant factors for being successful in the competitive global market is improving quality of customer servicing and focusing on customer satisfaction. In this paper, we introduce a vehicle routing and scheduling problem with cross-docking and time windows in a three-echelon supply chain that considers customer satisfaction. A set of homogeneous vehicles collect products from suppliers and after consolidation process in the cross-dock, immediately deliver them to customers. A mixed integer linear programming model is presented for this problem to minimize transportation cost and early/tardy deliveries with scheduling of inbound and outbound vehicles to increase customer satisfaction. A two phase genetic algorithm (GA) is developed for the problem. For investigating the performance of the algorithm, it was compared with exact and lower bound solutions in small and large-size instances, respectively. Results show that there are at least 86.6% customer satisfaction by the proposed method, whereas customer satisfaction in the classical model is at most 33.3%. Numerical examples results show that the proposed two phase algorithm could achieve optimal solutions in small-size instances. Also in large-size instances, the proposed two phase algorithm could achieve better solutions with less gap from the lower bound in less computational time in comparison with the classic GA.

  12. Assessment of Mono- and Split-Window Approaches for Time Series Processing of LST from AVHRR—A TIMELINE Round Robin

    Directory of Open Access Journals (Sweden)

    Corinne Myrtha Frey

    2017-01-01

    Full Text Available Processing of land surface temperature from long time series of AVHRR (Advanced Very High Resolution Radiometer requires stable algorithms, which are well characterized in terms of accuracy, precision and sensitivity. This assessment presents a comparison of four mono-window (Price 1983, Qin et al., 2001, Jiménez-Muñoz and Sobrino 2003, linear approach and six split-window algorithms (Price 1984, Becker and Li 1990, Ulivieri et al., 1994, Wan and Dozier 1996, Yu 2008, Jiménez-Muñoz and Sobrino 2008 to estimate LST from top of atmosphere brightness temperatures, emissivity and columnar water vapour. Where possible, new coefficients were estimated matching the spectral response curves of the different AVHRR sensors of the past and present. The consideration of unique spectral response curves is necessary to avoid artificial anomalies and wrong trends when processing time series data. Using simulated data on the base of a large atmospheric profile database covering many different states of the atmosphere, biomes and geographical regions, it was assessed (a to what accuracy and precision LST can be estimated using before mentioned algorithms and (b how sensitive the algorithms are to errors in their input variables. It was found, that the split-window algorithms performed almost equally well, differences were found mainly in their sensitivity to input bands, resulting in the Becker and Li 1990 and Price 1984 split-window algorithm to perform best. Amongst the mono-window algorithms, larger deviations occurred in terms of accuracy, precision and sensitivity. The Qin et al., 2001 algorithm was found to be the best performing mono-window algorithm. A short comparison of the application of the Becker and Li 1990 coefficients to AVHRR with the MODIS LST product confirmed the approach to be physically sound.

  13. Gendered Expectations? Reconsidering Single Fathers' Child-Care Time

    Science.gov (United States)

    Hook, Jennifer L.; Chalasani, Satvika

    2008-01-01

    We take a fresh look at an important question in the sociology of gender and family: Do single fathers "mother"? We add to the theoretical debate by proposing that single fathers face competing interactional pressures, to simultaneously act like mothers and men. Using nationally representative data from the American Time Use Survey 2003-2006 (N =…

  14. Large-scale analysis of acute ethanol exposure in zebrafish development: a critical time window and resilience.

    Directory of Open Access Journals (Sweden)

    Shaukat Ali

    Full Text Available BACKGROUND: In humans, ethanol exposure during pregnancy causes a spectrum of developmental defects (fetal alcohol syndrome or FAS. Individuals vary in phenotypic expression. Zebrafish embryos develop FAS-like features after ethanol exposure. In this study, we ask whether stage-specific effects of ethanol can be identified in the zebrafish, and if so, whether they allow the pinpointing of sensitive developmental mechanisms. We have therefore conducted the first large-scale (>1500 embryos analysis of acute, stage-specific drug effects on zebrafish development, with a large panel of readouts. METHODOLOGY/PRINCIPAL FINDINGS: Zebrafish embryos were raised in 96-well plates. Range-finding indicated that 10% ethanol for 1 h was suitable for an acute exposure regime. High-resolution magic-angle spinning proton magnetic resonance spectroscopy showed that this produced a transient pulse of 0.86% concentration of ethanol in the embryo within the chorion. Survivors at 5 days postfertilisation were analysed. Phenotypes ranged from normal (resilient to severely malformed. Ethanol exposure at early stages caused high mortality (≥88%. At later stages of exposure, mortality declined and malformations developed. Pharyngeal arch hypoplasia and behavioral impairment were most common after prim-6 and prim-16 exposure. By contrast, microphthalmia and growth retardation were stage-independent. CONCLUSIONS: Our findings show that some ethanol effects are strongly stage-dependent. The phenotypes mimic key aspects of FAS including craniofacial abnormality, microphthalmia, growth retardation and behavioral impairment. We also identify a critical time window (prim-6 and prim-16 for ethanol sensitivity. Finally, our identification of a wide phenotypic spectrum is reminiscent of human FAS, and may provide a useful model for studying disease resilience.

  15. The time window for therapy with peptide nanofibers combined with autologous bone marrow cells in pigs after acute myocardial infarction.

    Directory of Open Access Journals (Sweden)

    Ming-Yao Chang

    Full Text Available We previously showed that injection of peptide nanofibers (NF combined with autologous bone marrow mononuclear cells (MNC immediately after coronary artery ligation improves cardiac performance in pigs. To evaluate the clinical feasibility, this study was performed to determine the therapeutic time window for NF/MNC therapy in acute myocardial infarction (MI.A total of 45 adult minipigs were randomly grouped into 7 groups: sham or MI plus treatment with NS (normal saline, or NF or MNC alone at 1 day (1D post-MI, or NF/MNC at 1, 4, or 7 days post-MI (N≥6. Cardiac function was assessed by echocardiography and ventricular catheterization. Compared with the NS control, pigs treated with NF/MNC at 1 day post-MI (NF/MC-1D had the greatest improvement in left ventricle ejection fraction (LVEF; 55.1±1.6%; P<0.01 vs. NS 2 months after MI. In contrast, pigs treated with either NF/MNC-4D or NF/MNC-7D showed 48.9±0.8% (P<0.05 vs. NS and 43.5±2.3% (n.s. vs. NS improvements, respectively. The +dP/dt and -dP/dt, infarct size and interstitial collagen content were also improved in the NF/MNC-1D and -4D groups but not in the -7D group. Mechanistically, MNC quality and the states of systemic inflammation and damaged heart tissue influence the therapeutic efficiency of NF/MNC therapy, as revealed by another independent study using 16 pigs.Injection of NF/MNC at 1 or 4 days, but not at 7 days post-MI, improves cardiac performance and prevents ventricular remodeling, confirming the importance of early intervention when using this therapy for acute MI.

  16. Modeling and Solving the Multi-depot Vehicle Routing Problem with Time Window by Considering the Flexible end Depot in Each Route

    Directory of Open Access Journals (Sweden)

    Mohammad Mirabi

    2016-11-01

    Full Text Available This paper considers the multi-depot vehicle routing problem with time window in which each vehicle starts from a depot and there is no need to return to its primary depot after serving customers. The mathematical model which is developed by new approach aims to minimizing the transportation cost including the travelled distance, the latest and the earliest arrival time penalties. Furthermore, in order to reduce the problem searching space, a novel GA clustering method is developed. Finally, Experiments are run on number problems of varying depots and time window, and customer sizes. The method is compared to two other clustering techniques, fuzzy C means (FCM and K-means algorithm. Experimental results show the robustness and effectiveness of the proposed algorithm.

  17. Applications of a saving method with max-min ant system to a vehicle routing problem with time windows and speed limits

    Directory of Open Access Journals (Sweden)

    Suphan Sodsoon

    2014-06-01

    Full Text Available This study aims to solve a Vehicle Routing Problem with Time Windows and Speed Limits (VRPTWSL, which has received considerable attention in recent years. The vehicle routing problem with time windows is an extension of the well-known Vehicle Routing Problem (VRP and involves a fleet of vehicles set of from a depot to serve a number of customers at different geographic locations with various demands within specific time and speed limits before returning to the depot eventually. To solve the problem, an efficient Saving Method-Max Min Ant System (Saving-MMAS with Local Search algorithm is applied. Using minimization of the total transportation costs as the objective of the extension VRPTWSL, a mathematic model is constructed. Finally, the Saving-MMAS algorithms indicated the good quality of the method in this problem.

  18. Optimization of time-correlated single photon counting spectrometer

    International Nuclear Information System (INIS)

    Zhang Xiufeng; Du Haiying; Sun Jinsheng

    2011-01-01

    The paper proposes a performance improving scheme for the conventional time-correlated single photon counting spectrometer and develops a high speed data acquisition card based on PCI bus and FPGA technologies. The card is used to replace the multi-channel analyzer to improve the capability and decrease the volume of the spectrometer. The process of operation is introduced along with the integration of the spectrometer system. Many standard samples are measured. The experimental results show that the sensitivity of the spectrometer is single photon counting, and the time resolution of fluorescence lifetime measurement can be picosecond level. The instrument could measure the time-resolved spectroscopy. (authors)

  19. Enhanced local bioavailability of single or compound drugs delivery to the inner ear through application of PLGA nanoparticles via round window administration.

    Science.gov (United States)

    Cai, Hui; Wen, Xingxing; Wen, Lu; Tirelli, Nicola; Zhang, Xiao; Zhang, Yue; Su, Huanpeng; Yang, Fan; Chen, Gang

    2014-01-01

    In this paper, the potential of poly(D,L-lactide-co-glycolide acid) (PLGA) nanoparticles (NPs) for carrying single or compound drugs traversing the round window membrane (RWM) was examined after the round window (RW) administration of different NPs to guinea pigs. First, coumarin-6 was incorporated into PLGA NPs as a fluorescent probe to investigate its ability to cross the RWM. Then, PLGA NPs with salvianolic acid B (Sal B), tanshinone IIA (TS IIA), and total panax notoginsenoside (PNS) including notoginsenoside R1 (R1), ginsenoside Rg1 (Rg1), and ginsenoside Rb1 (Rb1) were developed to evaluate whether NPs loaded with compound drugs would pass through the RWM and improve the local bioavailability of these agents. PLGA NPs loaded with single or compound drugs were prepared by the emulsification solvent evaporation method, and their particle size distribution, particle morphology, and encapsulation efficiency were characterized. In vitro release study showed sustained-release profiles of Sal B, TS IIA, and PNS from the NPs. The pharmacokinetic results showed that NPs applied to the RWM significantly improved drug distribution within the inner ear. The AUC0-t of coumarin-6 in the perilymph (PL) following RW administration of NPs was 4.7-fold higher than that of coumarin-6 solution, and the Cmax was 10.9-fold higher. Furthermore, the AUC(0-t) of R1, Rg1, and Rb1 were 4.0-, 3.1-, and 7.1-fold greater, respectively, after the application of NPs compared to the compound solution, and the Cmax were, respectively, 14.4-, 10.0-, and 16.7-fold higher. These findings suggest that PLGA NPs with unique properties at the nanoscale dimensions have a powerful ability to transport single or compound drugs into the PL through the RWM and remarkably enhance the local bioavailability of the encapsulated drugs in the inner ear. The use of PLGA NPs as nanoscale delivery vehicles to carry drugs across the RWM may be a promising strategy for the treatment of inner ear diseases.

  20. Sunlight Responsive Thermochromic Window System

    Energy Technology Data Exchange (ETDEWEB)

    Millett, F,A; Byker,H, J

    2006-10-27

    Pleotint has embarked on a novel approach with our Sunlight Responsive Thermochromic, SRT™, windows. We are integrating dynamic sunlight control, high insulation values and low solar heat gain together in a high performance window. The Pleotint SRT window is dynamic because it reversibly changes light transmission based on thermochromics activated directly by the heating effect of sunlight. We can achieve a window package with low solar heat gain coefficient (SHGC), a low U value and high insulation. At the same time our windows provide good daylighting. Our innovative window design offers architects and building designers the opportunity to choose their desired energy performance, excellent sound reduction, external pane can be self-cleaning, or a resistance to wind load, blasts, bullets or hurricanes. SRT windows would provide energy savings that are estimated at up to 30% over traditional window systems. Glass fabricators will be able to use existing equipment to make the SRT window while adding value and flexibility to the basic design. Glazing installers will have the ability to fit the windows with traditional methods without wires, power supplies and controllers. SRT windows can be retrofit into existing buildings,

  1. Simple cryogenic infrared window

    NARCIS (Netherlands)

    Hartemink, M.; Hartemink, M.; Godfried, H.P; Godfried, Herman

    1991-01-01

    A simple, cheap technique is reported that allows materials with both large and small thermal expansion coefficients to be mounted as windows in low temperature cryostats while at the same time avoiding thermal stresses. The construction may be thermally cycled many times with no change in its

  2. A granular t abu search algorithm for a real case study of a vehicle routing problem with a heterogeneous fleet and time windows

    Energy Technology Data Exchange (ETDEWEB)

    Bernal, Jose; Escobar, John Willmer; Linfati, Rodrigo

    2017-07-01

    We consider a real case study of a vehicle routing problem with a heterogeneous fleet and time windows (HFVRPTW) for a franchise company bottling Coca-Cola products in Colombia. This study aims to determine the routes to be performed to fulfill the demand of the customers by using a heterogeneous fleet and considering soft time windows. The objective is to minimize the distance traveled by the performed routes. Design/methodology/approach: We propose a two-phase heuristic algorithm. In the proposed approach, after an initial phase (first phase), a granular tabu search is applied during the improvement phase (second phase). Two additional procedures are considered to help that the algorithm could escape from local optimum, given that during a given number of iterations there has been no improvement. Findings: Computational experiments on real instances show that the proposed algorithm is able to obtain high-quality solutions within a short computing time compared to the results found by the software that the company currently uses to plan the daily routes. Originality/value: We propose a novel metaheuristic algorithm for solving a real routing problem by considering heterogeneous fleet and time windows. The efficiency of the proposed approach has been tested on real instances, and the computational experiments shown its applicability and performance for solving NP-Hard Problems related with routing problems with similar characteristics. The proposed algorithm was able to improve some of the current solutions applied by the company by reducing the route length and the number of vehicles.

  3. A granular t abu search algorithm for a real case study of a vehicle routing problem with a heterogeneous fleet and time windows

    International Nuclear Information System (INIS)

    Bernal, Jose; Escobar, John Willmer; Linfati, Rodrigo

    2017-01-01

    We consider a real case study of a vehicle routing problem with a heterogeneous fleet and time windows (HFVRPTW) for a franchise company bottling Coca-Cola products in Colombia. This study aims to determine the routes to be performed to fulfill the demand of the customers by using a heterogeneous fleet and considering soft time windows. The objective is to minimize the distance traveled by the performed routes. Design/methodology/approach: We propose a two-phase heuristic algorithm. In the proposed approach, after an initial phase (first phase), a granular tabu search is applied during the improvement phase (second phase). Two additional procedures are considered to help that the algorithm could escape from local optimum, given that during a given number of iterations there has been no improvement. Findings: Computational experiments on real instances show that the proposed algorithm is able to obtain high-quality solutions within a short computing time compared to the results found by the software that the company currently uses to plan the daily routes. Originality/value: We propose a novel metaheuristic algorithm for solving a real routing problem by considering heterogeneous fleet and time windows. The efficiency of the proposed approach has been tested on real instances, and the computational experiments shown its applicability and performance for solving NP-Hard Problems related with routing problems with similar characteristics. The proposed algorithm was able to improve some of the current solutions applied by the company by reducing the route length and the number of vehicles.

  4. Advanced time-correlated single photon counting applications

    CERN Document Server

    Becker, Wolfgang

    2015-01-01

    This book is an attempt to bridge the gap between the instrumental principles of multi-dimensional time-correlated single photon counting (TCSPC) and typical applications of the technique. Written by an originator of the technique and by sucessful users, it covers the basic principles of the technique, its interaction with optical imaging methods and its application to a wide range of experimental tasks in life sciences and clinical research. The book is recommended for all users of time-resolved detection techniques in biology, bio-chemistry, spectroscopy of live systems, live cell microscopy, clinical imaging, spectroscopy of single molecules, and other applications that require the detection of low-level light signals at single-photon sensitivity and picosecond time resolution.

  5. Delayed intrinsic activation of an NMDA-independent CaM-kinase II in a critical time window is necessary for late consolidation of an associative memory.

    Science.gov (United States)

    Wan, Huimin; Mackay, Beth; Iqbal, Hassan; Naskar, Souvik; Kemenes, György

    2010-01-06

    Calcium/calmodulin-dependent kinases (CaM-kinases) are central to various forms of long-term memory (LTM) in a number of evolutionarily diverse organisms. However, it is still largely unknown what contributions specific CaM-kinases make to different phases of the same specific type of memory, such as acquisition, or early, intermediate, and late consolidation of associative LTM after classical conditioning. Here, we investigated the involvement of CaM-kinase II (CaMKII) in different phases of associative LTM induced by single-trial reward classical conditioning in Lymnaea, a well established invertebrate experimental system for studying molecular mechanisms of learning and memory. First, by using a general CaM-kinase inhibitor, KN-62, we found that CaM-kinase activation was necessary for acquisition and late consolidation, but not early or intermediate consolidation or retrieval of LTM. Then, we used Western blot-based phosphorylation assays and treatment with CaMKIINtide to identify CaMKII as the main CaM-kinase, the intrinsic activation of which, in a critical time window ( approximately 24 h after learning), is central to late consolidation of LTM. Additionally, using MK-801 and CaMKIINtide we found that acquisition was dependent on both NMDA receptor and CaMKII activation. However, unlike acquisition, CaMKII-dependent late memory consolidation does not require the activation of NMDA receptors. Our new findings support the notion that even apparently stable memory traces may undergo further molecular changes and identify NMDA-independent intrinsic activation of CaMKII as a mechanism underlying this "lingering consolidation." This process may facilitate the preservation of LTM in the face of protein turnover or active molecular processes that underlie forgetting.

  6. Window shopping

    OpenAIRE

    Oz Shy

    2013-01-01

    The terms "window shopping" and "showrooming" refer to the activity in which potential buyers visit a brick-and-mortar store to examine a product but end up either not buying it or buying the product from an online retailer. This paper analyzes potential buyers who differ in their preference for after-sale service that is not offered by online retailers. For some buyers, making a trip to the brick-and-mortar store is costly; however, going to the store to examine the product has the advantage...

  7. Window materials for high power gyrotron

    Energy Technology Data Exchange (ETDEWEB)

    Afsar, M.N.; Chi, H. [Tufts Univ., Medford, MA (United States)

    1994-07-01

    The room temperature application of sapphire as window material at higher frequencies is not feasible since its absorption coefficient increases almost linearly with increasing frequency in the millimeter wavelength region. At cryogenic temperature the absorption coefficient value decreases only by a few factors (factor of 2 to 3) in the 90-200 GHz region. The earlier reported temperature squared dependence (decrease) in the absorption coefficient or the loss tangent value is totally absent in the broad band continuous wave data the authors are reporting here (at 6.5 K, 35K, 77K and 300K) and one they reported at conferences earlier. These results are verified by another technique. The authors utilize their precision millimeter wave dispersive Fourier transform spectroscopic techniques at room temperature and at cryogenic temperatures. The extra high resistivity single crystal compensated silicon is no doubt the lowest loss material available at room temperature in the entire millimeter wavelength region. At higher millimeter wave frequencies an extra high resistivity silicon window or a window made with extra high resistivity silicon coated with diamond film would certainly make a better candidate in the future. A single free standing synthetic diamond window seems to have higher absorption coefficient values at millimeter wavelength region at this time although it is claimed that it possesses good mechanical strength and higher thermal conductivity characteristics. It certainly does not rule out the use of diamond film on a single crystal high resistivity silicon to improve its mechanical strength and thermal conductivity.

  8. Psychological Effects of Resting in Natural Environments: Improved choice reaction time and more efficient heart rate restoration as a function of resting with a window view of nature

    OpenAIRE

    Engell, Thomas

    2013-01-01

    Research indicates that natural environments can induce restorative effects on cognitive capacity and autonomic arousal, yielding improvements in cognitive functioning and more efficient heart rate restoration. The present study investigates differences in choice reaction time (CRT) and heart rate variability (HRV) in students (N=10) resting with or without a window view of a natural environment after a minor physical exertion. Subjects performed a pre-test of a Deary-Liewald choice reaction ...

  9. Time expansion chamber and single ionization cluster measurement

    International Nuclear Information System (INIS)

    Walenta, A.H.

    1978-10-01

    The time expansion chamber (TEC), a new type of drift chamber, allows the measurement of microscopic details of ionization. The mean drift time interval from subsequent sngle ionization clusters of a relativistic particle in the TEC can be made large enough compared to the width of a anode signal to allow the recording of the clusters separately. Since single primary electrons can be detected, the cluster counting would allow an improved particle separation using the relativistic rise of primary ionization. In another application, very high position accuracy for track detectors or improved energy resolution may be obtained. Basic ionization phenomena and drift properties can be measured at the single electron level

  10. Online Scheduling on a Single Machine with Grouped Processing Times

    Directory of Open Access Journals (Sweden)

    Qijia Liu

    2015-01-01

    Full Text Available We consider the online scheduling problem on a single machine with the assumption that all jobs have their processing times in [p,(1+αp], where p>0 and α=(5-1/2. All jobs arrive over time, and each job and its processing time become known at its arrival time. The jobs should be first processed on a single machine and then delivered by a vehicle to some customer. When the capacity of the vehicle is infinite, we provide an online algorithm with the best competitive ratio of (5+1/2. When the capacity of the vehicle is finite, that is, the vehicle can deliver at most c jobs at a time, we provide another best possible online algorithm with the competitive ratio of (5+1/2.

  11. Feasible Initial Population with Genetic Diversity for a Population-Based Algorithm Applied to the Vehicle Routing Problem with Time Windows

    Directory of Open Access Journals (Sweden)

    Marco Antonio Cruz-Chávez

    2016-01-01

    Full Text Available A stochastic algorithm for obtaining feasible initial populations to the Vehicle Routing Problem with Time Windows is presented. The theoretical formulation for the Vehicle Routing Problem with Time Windows is explained. The proposed method is primarily divided into a clustering algorithm and a two-phase algorithm. The first step is the application of a modified k-means clustering algorithm which is proposed in this paper. The two-phase algorithm evaluates a partial solution to transform it into a feasible individual. The two-phase algorithm consists of a hybridization of four kinds of insertions which interact randomly to obtain feasible individuals. It has been proven that different kinds of insertions impact the diversity among individuals in initial populations, which is crucial for population-based algorithm behavior. A modification to the Hamming distance method is applied to the populations generated for the Vehicle Routing Problem with Time Windows to evaluate their diversity. Experimental tests were performed based on the Solomon benchmarking. Experimental results show that the proposed method facilitates generation of highly diverse populations, which vary according to the type and distribution of the instances.

  12. Window observers for linear systems

    Directory of Open Access Journals (Sweden)

    Utkin Vadim

    2000-01-01

    Full Text Available Given a linear system x ˙ = A x + B u with output y = C x and a window function ω ( t , i.e., ∀ t , ω ( t ∈ {0,1 }, and assuming that the window function is Lebesgue measurable, we refer to the following observer, x ˆ = A x + B u + ω ( t L C ( x − x ˆ as a window observer. The stability issue is treated in this paper. It is proven that for linear time-invariant systems, the window observer can be stabilized by an appropriate design under a very mild condition on the window functions, albeit for linear time-varying system, some regularity of the window functions is required to achieve observer designs with the asymptotic stability. The corresponding design methods are developed. An example is included to illustrate the possible applications

  13. Time-resolved single-shot terahertz time-domain spectroscopy for ultrafast irreversible processes

    Science.gov (United States)

    Zhai, Zhao-Hui; Zhong, Sen-Cheng; Li, Jun; Zhu, Li-Guo; Meng, Kun; Li, Jiang; Liu, Qiao; Peng, Qi-Xian; Li, Ze-Ren; Zhao, Jian-Heng

    2016-09-01

    Pulsed terahertz spectroscopy is suitable for spectroscopic diagnostics of ultrafast events. However, the study of irreversible or single shot ultrafast events requires ability to record transient properties at multiple time delays, i.e., time resolved at single shot level, which is not available currently. Here by angular multiplexing use of femtosecond laser pulses, we developed and demonstrated a time resolved, transient terahertz time domain spectroscopy technique, where burst mode THz pulses were generated and then detected in a single shot measurement manner. The burst mode THz pulses contain 2 sub-THz pulses, and the time gap between them is adjustable up to 1 ns with picosecond accuracy, thus it can be used to probe the single shot event at two different time delays. The system can detect the sub-THz pulses at 0.1 THz-2.5 THz range with signal to noise ratio (SNR) of ˜400 and spectrum resolution of 0.05 THz. System design was described here, and optimizations of single shot measurement of THz pulses were discussed in detail. Methods to improve SNR were also discussed in detail. A system application was demonstrated where pulsed THz signals at different time delays of the ultrafast process were successfully acquired within single shot measurement. This time resolved transient terahertz time domain spectroscopy technique provides a new diagnostic tool for irreversible or single shot ultrafast events where dynamic information can be extracted at terahertz range within one-shot experiment.

  14. A Timing Single Channel Analyzer with pileup rejection

    International Nuclear Information System (INIS)

    Lauch, J.; Nachbar, H.U.

    1981-07-01

    A Timing Single Channel Analyzer is described as normally used in nuclear physics applications for measuring certain ranges of energy spectra. The unit accepts unipolar or bipolar gaussian shaped or rectangular pulses and includes a special pileup rejection circuit. Because of its good timing performance high resolution timing and coincidence measurements are possible. The differential analyzer, trigger and timing modes and the function of external strobe and gate signals are explained. Parts of the circuit are illustrated by help of block diagrams and pulse schematics. An essential part of the unit is the pileup rejection circuit. Following theoretical reflections the circuit is described and some measurement results are reported. (orig.) [de

  15. Opening the Literature Window

    Science.gov (United States)

    Jago, Carol

    2012-01-01

    Great literature gives students a window to other places and times, but it often requires students to step outside their comfort zones and take on challenges they wouldn't usually attempt. Unfortunately, research shows that many schools are not assigning literature that pushes students beyond their current reading level. Jago encourages teachers…

  16. A single dose of dexamethasone encapsulated in polyethylene glycol-coated polylactic acid nanoparticles attenuates cisplatin-induced hearing loss following round window membrane administration.

    Science.gov (United States)

    Sun, Changling; Wang, Xueling; Zheng, Zhaozhu; Chen, Dongye; Wang, Xiaoqin; Shi, Fuxin; Yu, Dehong; Wu, Hao

    2015-01-01

    This study aimed to investigate the sustained drug release properties and hearing protection effect of polyethylene glycol-coated polylactic acid (PEG-PLA) stealth nanoparticles loaded with dexamethasone (DEX). DEX was fabricated into PEG-PLA nanoparticles using an emulsion and evaporation technique, as previously reported. The DEX-loaded PEG-PLA nanoparticles (DEX-NPs) had a hydrodynamic diameter of 130±4.78 nm, and a zeta potential of -26.13±3.28 mV. The in vitro release of DEX from DEX-NPs lasted 24 days in phosphate buffered saline (pH 7.4), 5 days in artificial perilymph (pH 7.4), and 1 day in rat plasma. Coumarin 6-labeled NPs placed onto the round window membrane (RWM) of guinea pigs penetrated RWM quickly and accumulated to the organs of Corti, stria vascularis, and spiral ganglion cells after 1 hour of administration. The DEX-NPs locally applied onto the RWM of guinea pigs by a single-dose administration continuously released DEX in 48 hours, which was significantly longer than the free DEX that was cleared out within 12 hours after administration at the same dose. Further functional studies showed that locally administrated single-dose DEX-NPs effectively preserved outer hair cells in guinea pigs after cisplatin insult and thus significantly attenuated hearing loss at 4 kHz and 8 kHz frequencies when compared to the control of free DEX formulation. Histological analyses indicated that the administration of DEX-NPs did not induce local inflammatory responses. Therefore, prolonged delivery of DEX by PEG-PLA nanoparticles through local RWM diffusion (administration) significantly protected the hair cells and auditory function in guinea pigs from cisplatin toxicity, as determined at both histological and functional levels, suggesting the potential therapeutic benefits in clinical applications.

  17. A versatile optical microscope for time-dependent single-molecule and single-particle spectroscopy.

    Science.gov (United States)

    Li, Hao; Yang, Haw

    2018-03-28

    This work reports the design and implementation of a multi-function optical microscope for time-dependent spectroscopy on single molecules and single nanoparticles. It integrates the now-routine single-object measurements into one standalone platform so that no reconfiguration is needed when switching between different types of sample or spectroscopy modes. The illumination modes include evanescent field through total internal reflection, dark-field illumination, and epi-excitation onto a diffraction-limited spot suitable for confocal detection. The detection modes include spectrally resolved line imaging, wide-field imaging with dual-color capability, and two-color single-element photon-counting detection. The switch between different spectroscopy and data acquisition modes is fully automated and executed through computer programming. The capability of this microscope is demonstrated through selected proof-of-principle experiments.

  18. A versatile optical microscope for time-dependent single-molecule and single-particle spectroscopy

    Science.gov (United States)

    Li, Hao; Yang, Haw

    2018-03-01

    This work reports the design and implementation of a multi-function optical microscope for time-dependent spectroscopy on single molecules and single nanoparticles. It integrates the now-routine single-object measurements into one standalone platform so that no reconfiguration is needed when switching between different types of sample or spectroscopy modes. The illumination modes include evanescent field through total internal reflection, dark-field illumination, and epi-excitation onto a diffraction-limited spot suitable for confocal detection. The detection modes include spectrally resolved line imaging, wide-field imaging with dual-color capability, and two-color single-element photon-counting detection. The switch between different spectroscopy and data acquisition modes is fully automated and executed through computer programming. The capability of this microscope is demonstrated through selected proof-of-principle experiments.

  19. Reaction-time-resolved measurements of laser-induced fluorescence in a shock tube with a single laser pulse

    Science.gov (United States)

    Zabeti, S.; Fikri, M.; Schulz, C.

    2017-11-01

    Shock tubes allow for the study of ultra-fast gas-phase reactions on the microsecond time scale. Because the repetition rate of the experiments is low, it is crucial to gain as much information as possible from each individual measurement. While reaction-time-resolved species concentration and temperature measurements with fast absorption methods are established, conventional laser-induced fluorescence (LIF) measurements with pulsed lasers provide data only at a single reaction time. Therefore, fluorescence methods have rarely been used in shock-tube diagnostics. In this paper, a novel experimental concept is presented that allows reaction-time-resolved LIF measurements with one single laser pulse using a test section that is equipped with several optical ports. After the passage of the shock wave, the reactive mixture is excited along the center of the tube with a 266-nm laser beam directed through a window in the end wall of the shock tube. The emitted LIF signal is collected through elongated sidewall windows and focused onto the entrance slit of an imaging spectrometer coupled to an intensified CCD camera. The one-dimensional spatial resolution of the measurement translates into a reaction-time-resolved measurement while the species information can be gained from the spectral axis of the detected two-dimensional image. Anisole pyrolysis was selected as the benchmark reaction to demonstrate the new apparatus.

  20. Activin/Nodal Signaling Supports Retinal Progenitor Specification in a Narrow Time Window during Pluripotent Stem Cell Neuralization

    Directory of Open Access Journals (Sweden)

    Michele Bertacchi

    2015-10-01

    Full Text Available Retinal progenitors are initially found in the anterior neural plate region known as the eye field, whereas neighboring areas undertake telencephalic or hypothalamic development. Eye field cells become specified by switching on a network of eye field transcription factors, but the extracellular cues activating this network remain unclear. In this study, we used chemically defined media to induce in vitro differentiation of mouse embryonic stem cells (ESCs toward eye field fates. Inhibition of Wnt/β-catenin signaling was sufficient to drive ESCs to telencephalic, but not retinal, fates. Instead, retinal progenitors could be generated from competent differentiating mouse ESCs by activation of Activin/Nodal signaling within a narrow temporal window corresponding to the emergence of primitive anterior neural progenitors. Activin also promoted eye field gene expression in differentiating human ESCs. Our results reveal insights into the mechanisms of eye field specification and open new avenues toward the generation of retinal progenitors for translational medicine.

  1. A granular tabu search algorithm for a real case study of a vehicle routing problem with a heterogeneous fleet and time windows

    Directory of Open Access Journals (Sweden)

    Jose Bernal

    2017-10-01

    Full Text Available Purpose: We consider a real case study of a vehicle routing problem with a heterogeneous fleet and time windows (HFVRPTW for a franchise company bottling Coca-Cola products in Colombia. This study aims to determine the routes to be performed to fulfill the demand of the customers by using a heterogeneous fleet and considering soft time windows. The objective is to minimize the distance traveled by the performed routes. Design/methodology/approach: We propose a two-phase heuristic algorithm. In the proposed approach, after an initial phase (first phase, a granular tabu search is applied during the improvement phase (second phase. Two additional procedures are considered to help that the algorithm could escape from local optimum, given that during a given number of iterations there has been no improvement. Findings: Computational experiments on real instances show that the proposed algorithm is able to obtain high-quality solutions within a short computing time compared to the results found by the software that the company currently uses to plan the daily routes. Originality/value: We propose a novel metaheuristic algorithm for solving a real routing problem by considering heterogeneous fleet and time windows. The efficiency of the proposed approach has been tested on real instances, and the computational experiments shown its applicability and performance for solving NP-Hard Problems related with routing problems with similar characteristics. The proposed algorithm was able to improve some of the current solutions applied by the company by reducing the route length and the number of vehicles.

  2. Particulate air pollution and circulating biomarkers among type 2 diabetic mellitus patients: the roles of particle size and time windows of exposure.

    Science.gov (United States)

    Wang, Cuicui; Chen, Renjie; Zhao, Zhuohui; Cai, Jing; Lu, Jianxiong; Ha, Sandie; Xu, Xiaohui; Chen, Xuan; Kan, Haidong

    2015-07-01

    Short-term associations between size-fractionated particulate matter (PM) air pollution and circulating biomarkers are not well established, especially among diabetes patients. We conducted a longitudinal panel study involving 6 repeated measurements of 12 circulating biomarkers among 35 diabetes patients from April to June, 2013 in Shanghai, China. Real-time number and mass concentrations of PM with multiple size fractions between 0.25 and 10 μm were measured. Linear mixed-effect models were used to explore the associations between size-fractionated PM concentrations and blood biomarkers at different time windows. Short-term exposure to PM was significantly associated with elevated levels of 5 biomarkers of inflammation, 3 biomarkers of coagulation and 1 vasoconstrictor. The effects varied considerably by particle size and time windows. Overall, PM with smaller size had stronger associations, and the most significant size fractions were 0.25-0.40 μm. Even 2 h exposure to PM can lead to a significant increase in biomarkers. The effects on biomarkers of inflammation and vasoconstriction were restricted to the first 12h after exposure, but the effects on coagulation persisted for 24-72 h. For example, an interquartile range increase in 2h average exposure to PM(0.25-0.40) was associated with 6-20% increase in biomarkers of inflammation, 19-38% in coagulation and 17% in vasoconstriction. PM had a stronger effect among male patients than female patients. Our results provided important evidence on the roles of the size and time windows of exposure in the PM-mediated effects on circulating biomarkers of inflammation, coagulation and vasoconstriction in diabetes patients in China. Copyright © 2015 Elsevier Inc. All rights reserved.

  3. Early administration of pyrrolidine dithiocarbamate extends the therapeutic time window of tissue plasminogen activator in a male rat model of embolic stroke.

    Science.gov (United States)

    Wang, Zhongxing; Shan, Weiran; Cao, Jiangbei; Wintermark, Max; Huang, Wenqi; Zuo, Zhiyi

    2018-03-01

    Tissue plasminogen activator (tPA) is used in fewer than 4% of patients after ischemic stroke because of its narrow therapeutic time window. We tested whether pyrrolidine dithiocarbamate (PDTC), a drug with multiple mechanisms to provide neuroprotection, can be used to extend the therapeutic time window of tPA. Three-month-old male Sprague-Dawley rats were subjected to embolic stroke in the area supplied by the right middle cerebral artery. tPA at 10 mg/kg was given intravenously 4 h after the onset of stroke. PDTC at 50 mg/kg was given via gastric gavage at 30 min or 4 h after the onset of stroke. Two days after the stroke, neurological outcome was evaluated and the right frontal cortex area 1 (Fr1), an ischemic penumbral region, was harvested for analysis. PDTC given at 30 min after the stroke reduced infarct volumes and improved neurological functions no matter whether the rats received tPA. PDTC also reduced tPA-increased hemorrhagic volumes. Consistent with these results, PDTC in the presence or absence of tPA treatment attenuated the increase of proinflammatory cytokines, oxidative stress and matrix metalloprotease 2 activity in the right Fr1. However, PDTC given at 4 h after the onset of stroke did not improve the neurological outcome of rats treated with or without tPA. Our results suggest that PDTC given at an early time point but not in a delayed phase provides neuroprotection against embolic stroke and may be used to extend the therapeutic time window of tPA. © 2017 Wiley Periodicals, Inc.

  4. A Temperature Window for the Synthesis of Single-Walled Carbon Nanotubes by Catalytic Chemical Vapor Deposition of CH4over Mo2-Fe10/MgO Catalyst

    Directory of Open Access Journals (Sweden)

    Yu Ouyang

    2009-01-01

    Full Text Available Abstract A temperature window for the synthesis of single-walled carbon nanotubes by catalytic chemical vapor deposition of CH4over Mo2-Fe10/MgO catalyst has been studied by Raman spectroscopy. The results showed that when the temperature is lower than 750 °C, there were few SWCNTs formed, and when the temperature is higher than 950 °C, mass amorphous carbons were formed in the SWCNTs bundles due to the self-decomposition of CH4. The temperature window of SWCNTs efficient growth is between 800 and 950 °C, and the optimum growth temperature is about 900 °C. These results were supported by transmission electron microscope images of samples formed under different temperatures. The temperature window is important for large-scale production of SWCNTs by catalytic chemical vapor deposition method.

  5. Thermal monitoring of gyrotron windows

    International Nuclear Information System (INIS)

    Huey, H.E.; Choi, E.; Hu, G.; Mundie, L.

    1983-01-01

    In a practical gyrotron device, the design of a reliable vacuum window to withstand high mean power densities is of utmost importance. Computer modelling of an actual window assumes a number of conditions including the power density profile, the electromagnetic wave attenuation constant of the window material and heat transfer coefficients. The last two factors can vary significantly with temperature. A technique for actually monitoring the real time temperature distribution over the window surface with an IR camera while the gyrotron is in operation has been developed. This measurement serves as an aid for developing the analysis of window designs. The ability to observe small hot spots due to tiny metallic specks on the window surface is also of great value in quality control and window failure prevention. The experimental arrangement involves an infrared camera (AGA780) with an indium antimonide detector (3-5 μm) observing the window through a grid pattern of tiny holes (cutoff for the 3rd harmonic of 60 GHz). A 12 0 FOV lens with a 12mm extension ring was used to defocus the grid. The thermal emissivity E /sub w/ approx. = 0.95. Thus, an IR measurement of the window is a surface temperature measurement. To minimize the problem of external reflections, the outside surface of the waveguide was painted black. This then requires a cool waveguide; room temperature is sufficient

  6. Holography through optically active windows

    Science.gov (United States)

    Decker, A. J.

    1979-01-01

    By using two orthogonally polarized reference beams, holograms can be recorded through stressed windows and the reconstructed virtual image will show no stress pattern. As shown analytically, the stress-pattern-free hologram is recordable for any polarization state of the object illumination. Hence, the more efficient nondepolarizing diffuser can be used in performing holography through stressed windows if two reference beams are used. Results are presented for a pair of machined polysulfone windows intended for use in a holographic flow-visualization setup in a single-stage-compressor test rig.

  7. Accuracy of single photoelectron time spread measurement of fast photomultipliers

    International Nuclear Information System (INIS)

    Leskovar, B.

    1975-01-01

    The accuracy of time spread measurements of fast photomultipliers was investigated, using single photoelectrons. The effect of the finite light pulse width on the measurement accuracy was determined and discussed. Experimental data were obtained on a special measuring system for light pulse widths ranging from 200 psec to 10 nsec, using fast photomultipliers 8850 and C31024 with optimized operating conditions for minimum transit time spread. A modified exponential function expression and curve-fitting parameters are given, which fit closely the experimentally obtained data over a wide dynamic range of light pulse widths. (U.S.)

  8. Influence of scanning time window on the binding potentials of dopamine transporter in the brain of healthy volunteers with 11C-CFT PET imaging

    International Nuclear Information System (INIS)

    Qiu Chun; Zuo Chuantao; Zhang Zhengwei; Wu Ping; Zhang Huiwei; Guan Yihui

    2013-01-01

    Objective: To find the optimal scanning time window and then set up the normal binding potentials (BPs) of 2β-carbomethoxy-3β-(4-fluorophenyl)-(N- 11 C-methyl) tropane ( 11 C-CFT) DAT PET/CT imaging. Methods: Thirty-one healthy volunteers (20 males, 11 females, average age: (55.7±2.3) years), who all gave written informed consent, were divided into three age and gender-matched groups according to block randomization. Each group underwent static PET/CT scan in different time windows from 40-60 min, 60-80 min to 80-100 min after 11 C-CFT injection. To determine the best scanning time window, the ratios of caudate and putamen of all volunteers were analyzed using automatic ROI method (caudate (putamen)/parieto-occipital cotex-1) and compared by one-way analysis of variance and the least significant difference (LSD) t test. The ratio of the same area between different age-groups and gender-groups was compared with independent two-sample t test. Results: Ratios of left caudate (2.08±0.06, 1.75±0.07 and 1.77±0.12 respectively), right anterior putamen (2.33±0.06, 1.95±0.09 and 2.08±0.12 respectively) and bilateral posterior putamen (left: 1.88±0.66, 1.55±0.88 and 1.72±0.09; right: 1.98±0.07, 1.61±0.09 and 1.69±0.12) were all different in three time windows (F=3.588, 3.345, 4.479, 3.557, all P<0.05). There were significant differences in ratios of left caudate, right anterior and bilateral posterior putamen between 40-60 min and the 60-80 min (all P<0.05), as well as the ratios of left caudate between 40-60 min and the 80-100 min group (P<0.05). While no valid differences in ratios of those areas were shown between the groups of 60-80 min and 80-100 min scanning time window (all P>0.05). DAT densities in right and left side of caudate, anterior and posterior putamen were significantly lower in the group over 60 years of age than those under 60 years (t=-3.260, -3.090, -3.270, -3.190, -2.270, -3.110, all P<0.05), but were not different between gender

  9. Alternative approach for management of an electrical storm in Brugada syndrome:Importance of primary ablation within a narrow time window

    Directory of Open Access Journals (Sweden)

    Ahmed Karim Talib, MD, PhD

    2016-06-01

    Full Text Available Placement of an implantable cardioverter–defibrillator (ICD is the only powerful treatment modality for Brugada syndrome in patients presenting with ventricular fibrillation (VF. For those whose first presentation is an electrical storm, pharmacologic therapy is typically used to control VF followed by ICD implantation. We report an alternative approach whereby, before ICD implantation, emergency catheter ablation of the VF-triggering premature ventricular contraction (PVC resulted in long-term VF-free survival. The results suggest that, because VF triggers appear in a narrow time window, ablation of the culprit PVCs that initiate VF before the index PVCs subside is a reasonable alternative approach.

  10. False Windows - Yesterday and Today

    Science.gov (United States)

    Niewitecki, Stefan

    2017-10-01

    The article is concerned with a very interesting aspect of architectural design, namely, a contradiction between the building functions and the necessity of giving the building a desired external appearance. One of the possibilities of reconciling this contradiction is using pseudo windows that are visible on the elevation and generally have the form of a black painted recess accompanied by frames and sashes and often single glazing. Of course, there are no windows or openings in the corresponding places in the walls inside the building. The article discusses the differences between false windows and blind widows (German: blende), also known as blank windows, which, in fact, are shallow recesses in the wall having the external appearance of an arcade or a window and which had already been used in Gothic architecture mostly for aesthetic reasons and sometimes to reduce the load of the wall. Moreover, the article describes various false windows that appeared later than blind windows because they did not appear until the 17th century. Contemporary false windows are also discussed and it is shown that contrary to the common belief they are widely used. In his research, the author not only used the Internet data but also carried out his own in situ exploration. The false windows constitute very interesting albeit rare elements of the architectural design of buildings. They have been used successfully for a few hundred years. It might seem that they should have been discarded by now but this has not happened. Quite contrary, since the second half of the 20th century there has been a rapid development of glass curtain walls that serve a similar function in contemporary buildings as the false windows once did, only in a more extensive way.

  11. Can a quantum state over time resemble a quantum state at a single time?

    Science.gov (United States)

    Horsman, Dominic; Heunen, Chris; Pusey, Matthew F; Barrett, Jonathan; Spekkens, Robert W

    2017-09-01

    The standard formalism of quantum theory treats space and time in fundamentally different ways. In particular, a composite system at a given time is represented by a joint state, but the formalism does not prescribe a joint state for a composite of systems at different times. If there were a way of defining such a joint state, this would potentially permit a more even-handed treatment of space and time, and would strengthen the existing analogy between quantum states and classical probability distributions. Under the assumption that the joint state over time is an operator on the tensor product of single-time Hilbert spaces, we analyse various proposals for such a joint state, including one due to Leifer and Spekkens, one due to Fitzsimons, Jones and Vedral, and another based on discrete Wigner functions. Finding various problems with each, we identify five criteria for a quantum joint state over time to satisfy if it is to play a role similar to the standard joint state for a composite system: that it is a Hermitian operator on the tensor product of the single-time Hilbert spaces; that it represents probabilistic mixing appropriately; that it has the appropriate classical limit; that it has the appropriate single-time marginals; that composing over multiple time steps is associative. We show that no construction satisfies all these requirements. If Hermiticity is dropped, then there is an essentially unique construction that satisfies the remaining four criteria.

  12. Relativity theory and time perception: single or multiple clocks?

    Science.gov (United States)

    Buhusi, Catalin V; Meck, Warren H

    2009-07-22

    Current theories of interval timing assume that humans and other animals time as if using a single, absolute stopwatch that can be stopped or reset on command. Here we evaluate the alternative view that psychological time is represented by multiple clocks, and that these clocks create separate temporal contexts by which duration is judged in a relative manner. Two predictions of the multiple-clock hypothesis were tested. First, that the multiple clocks can be manipulated (stopped and/or reset) independently. Second, that an event of a given physical duration would be perceived as having different durations in different temporal contexts, i.e., would be judged differently by each clock. Rats were trained to time three durations (e.g., 10, 30, and 90 s). When timing was interrupted by an unexpected gap in the signal, rats reset the clock used to time the "short" duration, stopped the "medium" duration clock, and continued to run the "long" duration clock. When the duration of the gap was manipulated, the rats reset these clocks in a hierarchical order, first the "short", then the "medium", and finally the "long" clock. Quantitative modeling assuming re-allocation of cognitive resources in proportion to the relative duration of the gap to the multiple, simultaneously timed event durations was used to account for the results. These results indicate that the three event durations were effectively timed by separate clocks operated independently, and that the same gap duration was judged relative to these three temporal contexts. Results suggest that the brain processes the duration of an event in a manner similar to Einstein's special relativity theory: A given time interval is registered differently by independent clocks dependent upon the context.

  13. Relativity theory and time perception: single or multiple clocks?

    Directory of Open Access Journals (Sweden)

    Catalin V Buhusi

    2009-07-01

    Full Text Available Current theories of interval timing assume that humans and other animals time as if using a single, absolute stopwatch that can be stopped or reset on command. Here we evaluate the alternative view that psychological time is represented by multiple clocks, and that these clocks create separate temporal contexts by which duration is judged in a relative manner. Two predictions of the multiple-clock hypothesis were tested. First, that the multiple clocks can be manipulated (stopped and/or reset independently. Second, that an event of a given physical duration would be perceived as having different durations in different temporal contexts, i.e., would be judged differently by each clock.Rats were trained to time three durations (e.g., 10, 30, and 90 s. When timing was interrupted by an unexpected gap in the signal, rats reset the clock used to time the "short" duration, stopped the "medium" duration clock, and continued to run the "long" duration clock. When the duration of the gap was manipulated, the rats reset these clocks in a hierarchical order, first the "short", then the "medium", and finally the "long" clock. Quantitative modeling assuming re-allocation of cognitive resources in proportion to the relative duration of the gap to the multiple, simultaneously timed event durations was used to account for the results.These results indicate that the three event durations were effectively timed by separate clocks operated independently, and that the same gap duration was judged relative to these three temporal contexts. Results suggest that the brain processes the duration of an event in a manner similar to Einstein's special relativity theory: A given time interval is registered differently by independent clocks dependent upon the context.

  14. Effects of Thermal Mass, Window Size, and Night-Time Ventilation on Peak Indoor Air Temperature in the Warm-Humid Climate of Ghana

    Directory of Open Access Journals (Sweden)

    S. Amos-Abanyie

    2013-01-01

    Full Text Available Most office buildings in the warm-humid sub-Saharan countries experience high cooling load because of the predominant use of sandcrete blocks which are of low thermal mass in construction and extensive use of glazing. Relatively, low night-time temperatures are not harnessed in cooling buildings because office openings remain closed after work hours. An optimization was performed through a sensitivity analysis-based simulation, using the Energy Plus (E+ simulation software to assess the effects of thermal mass, window size, and night ventilation on peak indoor air temperature (PIAT. An experimental system was designed based on the features of the most promising simulation model, constructed and monitored, and the experimental data used to validate the simulation model. The results show that an optimization of thermal mass and window size coupled with activation of night-time ventilation provides a synergistic effect to obtain reduced peak indoor air temperature. An expression that predicts, indoor maximum temperature has been derived for models of various thermal masses.

  15. Total Body Irradiation Mitigates Inflammation and Extends the Therapeutic Time Window for Anti-Ricin Antibody Treatment against Pulmonary Ricinosis in Mice

    Directory of Open Access Journals (Sweden)

    Yoav Gal

    2017-09-01

    Full Text Available Ricin, a highly toxic plant-derived toxin, is considered a potential weapon in biowarfare and bioterrorism due to its pronounced toxicity, high availability, and ease of preparation. Pulmonary exposure to ricin results in the generation of an acute edematous inflammation followed by respiratory insufficiency and death. Massive neutrophil recruitment to the lungs may contribute significantly to ricin-mediated morbidity. In this study, total body irradiation (TBI served as a non-pharmacological tool to decrease the potential neutrophil-induced lung injury. TBI significantly postponed the time to death of intranasally ricin-intoxicated mice, given that leukopenia remained stable following intoxication. This increase in time to death coincided with a significant reduction in pro-inflammatory marker levels, and led to marked extension of the therapeutic time window for anti-ricin antibody treatment.

  16. Time-resolved gamma spectroscopy of single events

    Science.gov (United States)

    Wolszczak, W.; Dorenbos, P.

    2018-04-01

    In this article we present a method of characterizing scintillating materials by digitization of each individual scintillation pulse followed by digital signal processing. With this technique it is possible to measure the pulse shape and the energy of an absorbed gamma photon on an event-by-event basis. In contrast to time-correlated single photon counting technique, the digital approach provides a faster measurement, an active noise suppression, and enables characterization of scintillation pulses simultaneously in two domains: time and energy. We applied this method to study the pulse shape change of a CsI(Tl) scintillator with energy of gamma excitation. We confirmed previously published results and revealed new details of the phenomenon.

  17. A single dose of dexamethasone encapsulated in polyethylene glycol-coated polylactic acid nanoparticles attenuates cisplatin-induced hearing loss following round window membrane administration

    Directory of Open Access Journals (Sweden)

    Sun CL

    2015-05-01

    Full Text Available Changling Sun,1,3,* Xueling Wang,1,* Zhaozhu Zheng,2 Dongye Chen,1 Xiaoqin Wang,2 Fuxin Shi,1 Dehong Yu,1 Hao Wu11Department of Otolaryngology–Head and Neck Surgery, Xinhua Hospital, Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, 2National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, 3Department of Otolaryngology–Head and Neck Surgery, Affiliated Hospital of Jiangnan University, The Fourth People’s Hospital of Wuxi City, Wuxi, People’s Republic of China*These authors have contributed equally to this workAbstract: This study aimed to investigate the sustained drug release properties and hearing protection effect of polyethylene glycol-coated polylactic acid (PEG-PLA stealth nanoparticles loaded with dexamethasone (DEX. DEX was fabricated into PEG-PLA nanoparticles using an emulsion and evaporation technique, as previously reported. The DEX-loaded PEG-PLA nanoparticles (DEX-NPs had a hydrodynamic diameter of 130±4.78 nm, and a zeta potential of -26.13±3.28 mV. The in vitro release of DEX from DEX-NPs lasted 24 days in phosphate buffered saline (pH 7.4, 5 days in artificial perilymph (pH 7.4, and 1 day in rat plasma. Coumarin 6-labeled NPs placed onto the round window membrane (RWM of guinea pigs penetrated RWM quickly and accumulated to the organs of Corti, stria vascularis, and spiral ganglion cells after 1 hour of administration. The DEX-NPs locally applied onto the RWM of guinea pigs by a single-dose administration continuously released DEX in 48 hours, which was significantly longer than the free DEX that was cleared out within 12 hours after administration at the same dose. Further functional studies showed that locally administrated single-dose DEX-NPs effectively preserved outer hair cells in guinea pigs after cisplatin insult and thus significantly attenuated hearing loss at 4 kHz and 8

  18. Time-window of early detection of response to concurrent chemoradiation in cervical cancer by using diffusion-weighted MR imaging: a pilot study

    International Nuclear Information System (INIS)

    Liu, Ying; Sun, Haoran; Bai, Renju; Ye, Zhaoxiang

    2015-01-01

    To investigate the feasibility of DWI in evaluating early therapeutic response of uterine cervical cancer to concurrent chemoradiation (CCR) and establish optimal time window for early detection of treatment response. This was a prospective study and informed consent was obtained from all patients. Thirty-three patients with uterine cervical cancer who received CCR underwent conventional MRI and DWI examinations prior to therapy (base-line) and at 3 days (postT1), 7 days (postT2), 14 days (postT3), 1 month (postT4) and 2 months (postT5) after the therapy initiated. Tumor response was determined by comparing the base-line and postT5 MRI by using RECIST criterion. Percentage ADC change (γADC) of complete response (CR) group at each follow up time was greater than that of partial response (PR) group, and the differences were significant at postT3 (p = 0.007), postT4 (p = 0.001), and postT5 (p = 0.019). There was positive correlation between γADC at each follow-up time and percentage size reduction at postT5. The day of 14 after the therapy initiated can be considered as the optimal time for monitoring early treatment response of uterine cervical cancer to CCR, and the representative and sensitive index was γADC. With the cut-off value of 35.4 %, the sensitivity and specificity for prediction of CR group were 100 % and 73.1 %, respectively. It is feasible to use DWI to predict and monitor early treatment response in patients with uterine cervical cancer that undergoing CCR, and optimal time window for early detection of tumor response is the day of 14 after therapy initiated

  19. Real-time single-shot electron bunch length measurements

    CERN Document Server

    Wilke, I; Gillespie, W A; Berden, G; Knippels, G M H; Meer, A F G

    2002-01-01

    Linear accelerators employed as drivers for X-ray free electron lasers (FELs) require relativistic electron bunch with sub-picosecond bunch length. Precise bunch length measurements are important for the tuning and operation of the FELs. Previously, we have demonstrated that electro-optic detection is a powerful technique for sub-picosecond electron bunch length measurements. In those experiments, the measured bunch length was the average of all electron bunches within a macropulse. Here, for the first time, we present the measurement of the length of individual electron bunches using a development of our previous technique. In this experiment, the longitudinal electron bunch shape is encoded electro-optically on to the frequency spectrum of a chirped laser pulse. Subsequently, the laser pulse is dispersed by a grating and the spectrum is imaged with a CCD camera. Single bunch measurements are achieved by using a nanosecond gated camera, and synchronizing the gate with both the electron bunch and the laser pu...

  20. Single-Index Additive Vector Autoregressive Time Series Models

    KAUST Repository

    LI, YEHUA

    2009-09-01

    We study a new class of nonlinear autoregressive models for vector time series, where the current vector depends on single-indexes defined on the past lags and the effects of different lags have an additive form. A sufficient condition is provided for stationarity of such models. We also study estimation of the proposed model using P-splines, hypothesis testing, asymptotics, selection of the order of the autoregression and of the smoothing parameters and nonlinear forecasting. We perform simulation experiments to evaluate our model in various settings. We illustrate our methodology on a climate data set and show that our model provides more accurate yearly forecasts of the El Niño phenomenon, the unusual warming of water in the Pacific Ocean. © 2009 Board of the Foundation of the Scandinavian Journal of Statistics.

  1. Three-dimensional window analysis for detecting positive selection at structural regions of proteins.

    Science.gov (United States)

    Suzuki, Yoshiyuki

    2004-12-01

    Detection of natural selection operating at the amino acid sequence level is important in the study of molecular evolution. Single-site analysis and one-dimensional window analysis can be used to detect selection when the biological functions of amino acid sites are unknown. Single-site analysis is useful when selection operates more or less constantly over evolutionary time, but less so when selection operates temporarily. One-dimensional window analysis is more sensitive than single-site analysis when the functions of amino acid sites in close proximity in the linear sequence are similar, although this is not always the case. Here I present a three-dimensional window analysis method for detecting selection given the three-dimensional structure of the protein of interest. In the three-dimensional structure, the window is defined as the sphere centered on the alpha-carbon of an amino acid site. The window size is the radius of the sphere. The sites whose alpha-carbons are included in the window are grouped for the neutrality test. The window is moved within the three-dimensional structure by sequentially moving the central site along the primary amino acid sequence. To detect positive selection, it may also be useful to group the surface-exposed sites in the window separately. Three-dimensional window analysis appears not only to be more sensitive than single-site analysis and one-dimensional window analysis but also to provide similar specificity for inferring positive selection in the analyses of the hemagglutinin and neuraminidase genes of human influenza A viruses. This method, however, may fail to detect selection when it operates only on a particular site, in which case single-site analysis may be preferred, although a large number of sequences is required.

  2. Generating a Square Switching Window for Timing Jitter Tolerant 160 Gb/s Demultiplexing by the Optical Fourier Transform Technique

    DEFF Research Database (Denmark)

    Oxenløwe, Leif Katsuo; Galili, Michael; Clausen, A. T:

    2006-01-01

    A square spectrum is optically Fourier transformed into a square pulse in the time domain. This is used to demultiplex a 160 Gb/s data signal with a significant increase in jitter tolerance to 2.6 ps.......A square spectrum is optically Fourier transformed into a square pulse in the time domain. This is used to demultiplex a 160 Gb/s data signal with a significant increase in jitter tolerance to 2.6 ps....

  3. Single Molecule 3D Orientation in Time and Space

    NARCIS (Netherlands)

    Börner, Richard; Ehrlich, Nicky; Hohlbein, Johannes; Hübner, Christian G.

    2016-01-01

    Interactions between single molecules profoundly depend on their mutual three-dimensional orientation. Recently, we demonstrated a technique that allows for orientation determination of single dipole emitters using a polarization-resolved distribution of fluorescence into several detection

  4. Active control of time-varying broadband noise and vibrations using a sliding-window Kalman filter

    NARCIS (Netherlands)

    van Ophem, S.; Berkhoff, Arthur P.; Sas, P.; Moens, D.; Denayer, H.

    2014-01-01

    Recently, a multiple-input/multiple-output Kalman filter technique was presented to control time-varying broadband noise and vibrations. By describing the feed-forward broadband active noise control problem in terms of a state estimation problem it was possible to achieve a faster rate of

  5. Characteristics of electromagnetic wave propagation in time-varying magnetized plasma in magnetic window region of reentry blackout mitigation

    Directory of Open Access Journals (Sweden)

    Hui Zhou

    2017-02-01

    Full Text Available The “magnetic window” is considered a promising means to eliminate reentry communication blackout. However, the turbulence of plasma sheath results in phase jitter and amplitude turbulence of electromagnetic (EM wave and may influence the eliminating effect. Therefore, the effect of fluctuating property of reentry plasma sheath on EM wave propagation when a magnetic field is used for eliminating blackout is investigated. For this purpose, a time-varying electron density model, which includes both temporal variation and spatial turbulence, is proposed. Hybrid matrix method is also employed to investigate the interaction between time-varying magnetized plasma and EM wave. The EM wave transmission coefficients in time-varying magnetized and unmagnetized plasmas are likewise compared. Simulation results show that amplitude variation and phase jitter also exist on transmitted EM wave, and the turbulent deviation increases as the degree of plasma fluctuates. Meanwhile, the fluctuation of transmitted EM wave attenuates at low-frequency passband and increases at high-frequency passband with the increasing magnetic field. That is, comparing with unmagnetized time-varying plasma, the fluctuation effect can be mitigated by using a magnetic field when the EM wave frequency is at low-frequency passband. However, the mitigating effect can be influenced by the nonuniformity of magnetic field.

  6. Catch the wave! Time-window sequential analysis of alertness stimulation in individuals with profound intellectual and multiple disabilities

    NARCIS (Netherlands)

    Munde, V. S.; Vlaskamp, C.; Maes, B.; Ruijssenaars, A. J. J. M.

    BackgroundWhile optimally activities are provided at those moments when the individual with profound intellectual and multiple disabilities (PIMD) is focused on the environment' or alert', detailed information about the impact that the design and timing of the activity has on alertness is lacking.

  7. Selecting suitable coherent processing time window lengths for ground-based ISAR imaging of cooperative sea vessels

    CSIR Research Space (South Africa)

    Abdul Gaffar, MY

    2009-09-01

    Full Text Available show that the vessels also possess roll and pitch motion as indicated by their bank and elevation angles, respectively, and this causes each vessel’s image-generating Doppler components to change with time. In addition, the period of the bank...-range information can be obtained by simply separating scatterers according to their Doppler frequency, as described by Wehner [5]. ISAR imaging of maritime vessels is a challenging task because their 3-D rotational motion (roll, pitch, and yaw rates) causes a...

  8. Surgery for subacromial impingement syndrome in relation to intensities of occupational mechanical exposures across 10-year exposure time windows

    DEFF Research Database (Denmark)

    Dalbøge, Annett; Frost, Poul; Andersen, Johan Hviid

    2018-01-01

    OBJECTIVES: We aimed to identify intensities of occupational mechanical exposures (force, arm elevation and repetition) that do not entail an increased risk of surgery for subacromial impingement syndrome (SIS) even after prolonged durations of exposure. Additionally, we wanted to evaluate...... if exposure to hand-arm vibration (HAV) is an independent risk factor. METHODS: We used data from a register-based cohort study of the entire Danish working population (n=2 374 403). During follow-up (2003-2008), 14 118 first-time events of surgery for SIS occurred. For each person, we linked register...... of exposure at specific intensities above minimal (low, medium and high). We used a logistic regression technique equivalent to discrete survival analysis adjusting for cumulative effects of other mechanical exposures. RESULTS: We found indications of safe exposure intensities for repetition (median angular...

  9. Windows 10 simplified

    CERN Document Server

    McFedries, Paul

    2015-01-01

    Learn Windows 10 quickly and painlessly with this beginner's guide Windows 10 Simplified is your absolute beginner's guide to the ins and outs of Windows. Fully updated to cover Windows 10, this highly visual guide covers all the new features in addition to the basics, giving you a one-stop resource for complete Windows 10 mastery. Every page features step-by-step screen shots and plain-English instructions that walk you through everything you need to know, no matter how new you are to Windows. You'll master the basics as you learn how to navigate the user interface, work with files, create

  10. Windows Terminal Servers Orchestration

    Science.gov (United States)

    Bukowiec, Sebastian; Gaspar, Ricardo; Smith, Tim

    2017-10-01

    Windows Terminal Servers provide application gateways for various parts of the CERN accelerator complex, used by hundreds of CERN users every day. The combination of new tools such as Puppet, HAProxy and Microsoft System Center suite enable automation of provisioning workflows to provide a terminal server infrastructure that can scale up and down in an automated manner. The orchestration does not only reduce the time and effort necessary to deploy new instances, but also facilitates operations such as patching, analysis and recreation of compromised nodes as well as catering for workload peaks.

  11. Time window for positive cerebrospinal fluid broad-range bacterial PCR and Streptococcus pneumoniae immunochromatographic test in acute bacterial meningitis.

    Science.gov (United States)

    Brink, Magnus; Welinder-Olsson, Christina; Hagberg, Lars

    2015-01-01

    Reliable microbiological tests are essential for the diagnosis of acute bacterial meningitis (ABM). In this study we investigated the time period after the start of antibiotic therapy during which culture, polymerase chain reaction (PCR) and the immunochromatographic test (ICT) are able to detect bacteria in cerebrospinal fluid (CSF). The study was performed on CSF samples from adults with ABM admitted to the Department of Infectious Diseases, Sahlgrenska University Hospital, Gothenburg, Sweden, from January 2007 to April 2014. In addition to the initial lumbar puncture (LP), the participants underwent one or two more LPs during 10 days following the start of antibiotics. The analyses performed on the CSF samples were culture, PCR and ICT. The study comprised 70 CSF samples from 25 patients with ABM. A bacterium could be identified by CSF culture in 44%, by blood culture in 58% and by PCR in 100% of the patients. There were no positive CSF cultures in samples taken later than the day of starting antibiotics. PCR was positive in 89% on days 1-3, 70% on days 4-6 and 33% on days 7-10. For cases of pneumococcal meningitis, the ICT was positive in 88% on days 1-3, 90% on days 4-6 and 75% on days 7-10. This study shows that PCR is highly sensitive for bacterial detection in CSF samples taken up to 1 week into antibiotic therapy. The ICT is highly sensitive for the detection of pneumococci in CSF samples taken during the first week of antibiotic treatment.

  12. Riparian woody vegetation history in the campos region, southeastern South America, during two time windows: late Pleistocene and late Holocene

    Science.gov (United States)

    Mourelle, Dominique; Prieto, Aldo R.; García-Rodríguez, Felipe

    2017-07-01

    A detailed palynological record from Laguna Formosa (northeastern campos region, 31°S; 54°W) documents the dynamic balance between grasslands and riparian forests during the late Pleistocene (14,570 to 13,500 cal yr BP) and late Holocene (3280 cal yr BP to the present). Modern pollen-vegetation relationships and the woody pollen dispersal capacity analyses were used to improve the vegetation reconstruction. Grasslands were regionally dominant throughout the record. However, at 14,570 cal yr BP hydrophilous taxa reflect the development of riparian hydrophilous shrublands along freshwater bodies, promoting the fixation of the riverbanks, maintaining shallow, calm and clear water conditions under a relatively wet and not so cool climate. This is the first evidence of woody riparian vegetation development along freshwater bodies for the lowlands of the northern campos during the late glacial period. At 3280 cal yr BP riparian forests consisted of both hydrophilous and mesophilous woody taxa. Since 2270 cal yr BP woody vegetation gradually increased, accompanied by the incorporation of other taxa by 940 cal yr BP, and achieving a composition similar to that of the contemporary time at ca. 540 cal yr BP. The increased woody vegetation since ca. 2270 cal yr BP, and the more frequent and intense flooding events between 1800 and 1200 cal yr BP, could be related to higher precipitation over La Plata Drainage Basin, related with the high ENSO amplitude. In addition, pollen from taxa that currently no longer develops in the study area suggests connections between southern Brazil and Uruguay, and between the campos and the Chaco phytogeographic province.

  13. Schematic Window Methodology Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The aim of this IRAD is to produce a generic launch window analyzer (SWM) that allows for large-scale rapid analysis of a launch window and orbit design trade space....

  14. Wide-field time-correlated single photon counting (TCSPC) microscopy with time resolution below the frame exposure time

    Energy Technology Data Exchange (ETDEWEB)

    Hirvonen, Liisa M. [Department of Physics, King' s College London, Strand, London WC2R 2LS (United Kingdom); Petrášek, Zdeněk [Max Planck Institute of Biochemistry, Department of Cellular and Molecular Biophysics, Am Klopferspitz 18, D-82152 Martinsried (Germany); Suhling, Klaus, E-mail: klaus.suhling@kcl.ac.uk [Department of Physics, King' s College London, Strand, London WC2R 2LS (United Kingdom)

    2015-07-01

    Fast frame rate CMOS cameras in combination with photon counting intensifiers can be used for fluorescence imaging with single photon sensitivity at kHz frame rates. We show here how the phosphor decay of the image intensifier can be exploited for accurate timing of photon arrival well below the camera exposure time. This is achieved by taking ratios of the intensity of the photon events in two subsequent frames, and effectively allows wide-field TCSPC. This technique was used for measuring decays of ruthenium compound Ru(dpp) with lifetimes as low as 1 μs with 18.5 μs frame exposure time, including in living HeLa cells, using around 0.1 μW excitation power. We speculate that by using an image intensifier with a faster phosphor decay to match a higher camera frame rate, photon arrival time measurements on the nanosecond time scale could well be possible.

  15. Pengaruh Window Level Dan Window Width Pada Lung Window Dan Mediastinum Window Pada Kualitas Citra CT-Scan Thorax

    OpenAIRE

    Gaol, Syahnaro Lumban

    2015-01-01

    This Research of image CT-SCAN thorax with influence of window level and window width, to obtain, get value of window level and optimal window width lung window and mediastinum window, so that get image of CT-SCAN thorax which with image quality. Image of CT-SCAN thorax obtained for mediastinum window use window width 350, 400, 450, 500 HU. And Window level 50,100,150 HU. While for lung window use window width 1000,1100 HU. The window level - 500-,600,-700,-800,-900,-1000 HU, by three observe...

  16. Windows for Intel Macs

    CERN Document Server

    Ogasawara, Todd

    2008-01-01

    Even the most devoted Mac OS X user may need to use Windows XP, or may just be curious about XP and its applications. This Short Cut is a concise guide for OS X users who need to quickly get comfortable and become productive with Windows XP basics on their Macs. It covers: Security Networking ApplicationsMac users can easily install and use Windows thanks to Boot Camp and Parallels Desktop for Mac. Boot Camp lets an Intel-based Mac install and boot Windows XP on its own hard drive partition. Parallels Desktop for Mac uses virtualization technology to run Windows XP (or other operating systems

  17. Windows® Internals

    CERN Document Server

    Russinovich, Mark E; Ionescu, Alex

    2009-01-01

    See how the core components of the Windows operating system work behind the scenes-guided by a team of internationally renowned internals experts. Fully updated for Windows Server 2008 and Windows Vista, this classic guide delivers key architectural insights on system design, debugging, performance, and support-along with hands-on experiments to experience Windows internal behavior firsthand.Delve inside Windows architecture and internals:Understand how the core system and management mechanisms work-from the object manager to services to the registryExplore internal system data structures usin

  18. Single item inventory models : A time- and event- averages approach

    NARCIS (Netherlands)

    E.M. Bazsa-Oldenkamp; P. den Iseger

    2003-01-01

    textabstractThis paper extends a fundamental result about single-item inventory systems. This approach allows more general performance measures, demand processes and order policies, and leads to easier analysis and implementation, than prior research. We obtain closed form expressions for the

  19. MRI versus CT-based thrombolysis treatment within and beyond the 3 h time window after stroke onset: a cohort study.

    Science.gov (United States)

    Köhrmann, Martin; Jüttler, Eric; Fiebach, Jochen B; Huttner, Hagen B; Siebert, Stefan; Schwark, Christian; Ringleb, Peter A; Schellinger, Peter D; Hacke, Werner

    2006-08-01

    Thrombolytic treatment with recombinant tissue plasminogen activator (rtPA) is approved for use within 3 h after stroke onset. Thus only a small percentage of patients can benefit. Meta-analyses and more recent studies suggest a benefit for a subset of patients beyond 3 h. We assessed the safety and efficacy of an MRI-based selection protocol for stroke treatment within and beyond 3 h compared with standard CT-based treatment. We assessed clinical outcome and incidence of symptomatic intracerebral haemorrhage (ICH) in 400 consecutive patients treated with intravenous rtPA. Patients eligible for thrombolysis within 3 h were selected by CT or MRI and beyond 3 h only by MRI. 18 patients were excluded from analysis because of violation of that algorithm. The remaining 382 patients were divided into three groups: CT-based treatment within 3 h (n=209); MRI-based treatment within 3 h (n=103); and MRI-based treatment beyond 3 h (n=70). Patients in group 3 (MRI > 3 h) had a similar 90 day outcome to those in the other two groups (48% were independent in the CT < or = 3 h group, 51% in the MRI < or = 3 h group, and 56% in group 3), but without an increased risk for symptomatic ICH (9%, 1%, 6%) or mortality (21%, 13%, 11%). MRI-selected patients overall had a significantly lower risk than CT-selected patients for symptomatic ICH (3% vs 9%; p=0.013) and mortality (12% vs 21%; p=0.021). Time to treatment did not affect outcomes in univariate and multivariate analyses. Our data suggest that beyond 3 h and maybe even within 3 h, patient selection is more important than time to treatment for a good outcome. Furthermore, MRI-based thrombolysis, irrespective of the time window, shows an improved safety profile while being at least as effective as standard CT-based treatment within 3 h.

  20. Windows 8.1 for dummies

    CERN Document Server

    Rathbone, Andy

    2013-01-01

    The bestselling book on Windows, now updated for the new 8.1 features Microsoft has fine-tuned Windows 8 with some important new features, and veteran author Andy Rathbone explains every one in this all-new edition of a long-time bestseller. Whether you're using Windows for the first time, upgrading from an older version, or just moving from Windows 8 to 8.1, here's what you need to know. Learn about the dual interfaces, the new Start button, how to customize the interface and boot operations, and how to work with programs and files, use the web and social media, manage music and photos, and

  1. MULTIPLE ANT COLONY SYSTEM FOR A VRP WITH TIME WINDOWS AND SCHEDULED LOADING MÚLTIPLES SISTEMAS DE COLONIAS DE HORMIGAS PARA UN VRP CON VENTANAS DE TIEMPO Y PROGRAMACIÓN DE LA CARGA

    Directory of Open Access Journals (Sweden)

    Pablo Ortega

    2009-12-01

    Full Text Available The vehicle routing problem with time windows and scheduled loading [VRPTWSL] requires not only the design of routes with time windows and capacity constraints, but also a schedule of the departures of vehicles from the depot given a load time due to the limited resources available to load the demand in the vehicles. A mathematical formulation of the vehicle routing problem with time windows and scheduled loading is presented and a metaheuristics based on Multiple Ant Colony System is proposed and implemented where two ant colonies, each with a single objective function, are organized in a hierarchical way. A time update procedure is incorporated into the ant constructive procedure to update and schedule the departure of a vehicle from the depot when each ant moves to a new customer-node. Constraint programming is used to determine a feasible move to a new customer-node. As [VRPTWSL] incorporates the vehicle departure scheduling, the algorithm presented in this paper has a direct application to real problems, in this way [VRPTWSL] can be taken as an important advance for practical vehicle routing problems.El problema de rutas para vehículos con ventanas de tiempo y programación de la carga no solo requiere el diseño de las rutas que satisfagan las restricciones temporales y de capacidad de los vehículos sino que también la programación de las salidas de los vehículos desde un terminal dado un tiempo de carga debido a los recursos limitados disponibles para cargar las demandas de los clientes en los vehículos. No solo se presenta una formulación del problema de diseño de rutas para vehículos con ventanas de tiempo y programación de la carga, sino que también se propone e implementa una metaheurística basada en múltiples sistemas de colonias de hormigas, cada una con una sola función objetivo, organizadas de manera jerárquica. Se incorpora una forma de actualización de tiempo dentro del procedimiento constructivo para actualizar

  2. High Power Coax Window

    International Nuclear Information System (INIS)

    Neubauer, M.L.; Dudas, A.; Sah, R.; Elliott, T.S.; Rimmer, R.A.; Stirbet, M.

    2010-01-01

    A superconducting RF (SRF) power coupler capable of handling 500 kW CW RF power is required for present and future storage rings and linacs. There are over 35 coupler designs for SRF cavities ranging in frequency from 325 to 1500 MHz. Coupler windows vary from cylinders to cones to disks, and RF power couplers are limited by the ability of ceramic windows to withstand the stresses due to heating and mechanical flexure. We propose a novel robust co-axial SRF coupler design which uses compressed window technology. This technology will allow the use of highly thermally conductive materials for cryogenic windows. Using compressed window techniques on disk co-axial windows will make significant improvements in the power handling of SRF couplers. We present the bench test results of two window assemblies back to back, as well as individual window VSWR in EIA3.125 coax. A vacuum test assembly was made and the windows baked out at 155C. The processes used to build windows is scalable to larger diameter coax and to higher power levels.

  3. Optimization of single injection liver arterial phase gadolinium enhanced MRI using bolus track real-time imaging.

    Science.gov (United States)

    Sharma, Puneet; Kalb, Bobby; Kitajima, Hiroumi D; Salman, Khalil N; Burrow, Bobbie; Ray, Gaye L; Martin, Diego R

    2011-01-01

    To measure contrast agent enhancement kinetics in the liver and to further evaluate and develop an optimized gadolinium enhanced MRI using a single injection real-time bolus-tracking method for reproducible imaging of the transient arterial-phase. A total of 18 subjects with hypervascular liver lesions were imaged with four dimensional (4D) perfusion scans to measure time-to-peak (TTP) delays of arterial (aorta-celiac axis), liver parenchyma, liver lesion, portal, and hepatic veins. Time delays were calculated from the TTP-aorta signal, and then related to the gradient echo (GRE) k-space acquisition design, to determine optimized timing for real-time bolus-track triggering methodology. As another measure of significance, 200 clinical patients were imaged with 3D-GRE using either a fixed time-interval or by individualized arterial bolus real-time triggering. Bolus TTP-aorta was calculated and arterial-phase acquisitions were compared for accuracy and reproducibility using specific vascular enhancement indicators. The mean bolus transit-time to peak-lesion contrast was 8.1 ± 2.7 seconds following arterial detection, compared to 32.1 ± 5.4 seconds from contrast injection, representing a 62.1% reduction in the time-variability among subjects (N = 18). The real-time bolus-triggered technique more consistently captured the targeted arterial phase (94%), compared to the fixed timing technique (73%), representing an expected improvement of timing accuracy in 28% of patients (P = 0.0001389). Our results show detailed timing window analysis required for optimized arterial real-time bolus-triggering acquisition of transient arterial phase features of liver lesions, with optimized arterial triggering expected to improve reproducibility in a significant number of patients. Copyright © 2010 Wiley-Liss, Inc.

  4. Solving a bi-objective mathematical model for location-routing problem with time windows in multi-echelon reverse logistics using metaheuristic procedure

    Science.gov (United States)

    Ghezavati, V. R.; Beigi, M.

    2016-12-01

    During the last decade, the stringent pressures from environmental and social requirements have spurred an interest in designing a reverse logistics (RL) network. The success of a logistics system may depend on the decisions of the facilities locations and vehicle routings. The location-routing problem (LRP) simultaneously locates the facilities and designs the travel routes for vehicles among established facilities and existing demand points. In this paper, the location-routing problem with time window (LRPTW) and homogeneous fleet type and designing a multi-echelon, and capacitated reverse logistics network, are considered which may arise in many real-life situations in logistics management. Our proposed RL network consists of hybrid collection/inspection centers, recovery centers and disposal centers. Here, we present a new bi-objective mathematical programming (BOMP) for LRPTW in reverse logistic. Since this type of problem is NP-hard, the non-dominated sorting genetic algorithm II (NSGA-II) is proposed to obtain the Pareto frontier for the given problem. Several numerical examples are presented to illustrate the effectiveness of the proposed model and algorithm. Also, the present work is an effort to effectively implement the ɛ-constraint method in GAMS software for producing the Pareto-optimal solutions in a BOMP. The results of the proposed algorithm have been compared with the ɛ-constraint method. The computational results show that the ɛ-constraint method is able to solve small-size instances to optimality within reasonable computing times, and for medium-to-large-sized problems, the proposed NSGA-II works better than the ɛ-constraint.

  5. Round window stimulation for conductive and mixed hearing loss.

    Science.gov (United States)

    Dillon, Margaret T; Tubbs, Rhonda S; Adunka, Marcia C; King, English R; Hillman, Todd A; Adunka, Oliver F; Chen, Douglas A; Buchman, Craig A

    2014-10-01

    Assess surgical complications, postoperative residual hearing, and speech perception outcomes of placement of a middle ear implant on the round window in conductive and mixed hearing loss cases. Single-subject, repeated-measures design where each subject served as his or her own control. Tertiary referral medical systems. Eighteen subjects with either conductive or mixed hearing loss who could not benefit from conventional amplification were enrolled in a clinical trial investigating vibratory stimulation of the round window. The floating mass transducer (FMT) was positioned in the round window niche. Unaided residual hearing, and aided sound field thresholds and speech perception abilities were evaluated preoperatively, and at 1, 3, 6, and 10 months post-activation of the external speech processor. Six subjects experienced complications that either required further medical management or resolved on their own. There was no difference in residual bone conduction thresholds or unaided word discrimination over time. All subjects experienced a significant improvement in aided speech perception abilities as compared to preoperative performance. Subjects with conductive and mixed hearing loss with placement of the FMT in the round window niche experienced improved sound field thresholds and speech perception, without compromising residual hearing thresholds. Vibratory stimulation of the round window via a middle ear implant may be an appropriate treatment option for patients with conductive and mixed hearing loss. Additional research is needed on the preferred placement of the FMT, improvement of functional gain, and methods to limit postoperative complications and need for revision surgery.

  6. SNS Proton Beam Window Disposal

    Directory of Open Access Journals (Sweden)

    Popova Irina

    2017-01-01

    Full Text Available In order to support the disposal of the proton beam window assembly of the Spallation Neutron Source beamline to the target station, waste classification analyses are performed. The window has a limited life-time due to radiation-induced material damage. Analyses include calculation of the radionuclide inventory and shielding analyses for the transport package/container to ensure that the container is compliant with the transportation and waste management regulations. In order to automate this procedure and minimize manual work a script in Perl language was written.

  7. Oscillatory integration windows in neurons

    Science.gov (United States)

    Gupta, Nitin; Singh, Swikriti Saran; Stopfer, Mark

    2016-01-01

    Oscillatory synchrony among neurons occurs in many species and brain areas, and has been proposed to help neural circuits process information. One hypothesis states that oscillatory input creates cyclic integration windows: specific times in each oscillatory cycle when postsynaptic neurons become especially responsive to inputs. With paired local field potential (LFP) and intracellular recordings and controlled stimulus manipulations we directly test this idea in the locust olfactory system. We find that inputs arriving in Kenyon cells (KCs) sum most effectively in a preferred window of the oscillation cycle. With a computational model, we show that the non-uniform structure of noise in the membrane potential helps mediate this process. Further experiments performed in vivo demonstrate that integration windows can form in the absence of inhibition and at a broad range of oscillation frequencies. Our results reveal how a fundamental coincidence-detection mechanism in a neural circuit functions to decode temporally organized spiking. PMID:27976720

  8. Magnetoresistive sensor for real-time single nucleotide polymorphism genotyping

    DEFF Research Database (Denmark)

    Rizzi, Giovanni; Østerberg, Frederik Westergaard; Dufva, Martin

    2014-01-01

    We demonstrate a magnetoresistive sensor platform that allows for the real-time detection of point mutations in DNA targets. Specifically, we detect point mutations at two sites in the human beta globin gene. For DNA detection, the present sensor technology has a detection limit of about 160p...... of magnetic beads, which enables real-time quantification of the specific binding of magnetic beads to the sensor surface under varying experimental conditions....

  9. Selective post-training time window for memory consolidation interference of cannabidiol into the prefrontal cortex: Reduced dopaminergic modulation and immediate gene expression in limbic circuits.

    Science.gov (United States)

    Rossignoli, Matheus Teixeira; Lopes-Aguiar, Cleiton; Ruggiero, Rafael Naime; Do Val da Silva, Raquel Araujo; Bueno-Junior, Lezio Soares; Kandratavicius, Ludmyla; Peixoto-Santos, José Eduardo; Crippa, José Alexandre; Cecilio Hallak, Jaime Eduardo; Zuardi, Antonio Waldo; Szawka, Raphael Escorsim; Anselmo-Franci, Janete; Leite, João Pereira; Romcy-Pereira, Rodrigo Neves

    2017-05-14

    The prefrontal cortex (PFC), amygdala and hippocampus display a coordinated activity during acquisition of associative fear memories. Evidence indicates that PFC engagement in aversive memory formation does not progress linearly as previously thought. Instead, it seems to be recruited at specific time windows after memory acquisition, which has implications for the treatment of post-traumatic stress disorders. Cannabidiol (CBD), the major non-psychotomimetic phytocannabinoid of the Cannabis sativa plant, is known to modulate contextual fear memory acquisition in rodents. However, it is still not clear how CBD interferes with PFC-dependent processes during post-training memory consolidation. Here, we tested whether intra-PFC infusions of CBD immediately after or 5h following contextual fear conditioning was able to interfere with memory consolidation. Neurochemical and cellular correlates of the CBD treatment were evaluated by the quantification of extracellular levels of dopamine (DA), serotonin, and their metabolites in the PFC and by measuring the cellular expression of activity-dependent transcription factors in cortical and limbic regions. Our results indicate that bilateral intra-PFC CBD infusion impaired contextual fear memory consolidation when applied 5h after conditioning, but had no effect when applied immediately after it. This effect was associated with a reduction in DA turnover in the PFC following retrieval 5days after training. We also observed that post-conditioning infusion of CBD reduced c-fos and zif-268 protein expression in the hippocampus, PFC, and thalamus. Our findings support that CBD interferes with contextual fear memory consolidation by reducing PFC influence on cortico-limbic circuits. Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

  10. Windows 8 secrets

    CERN Document Server

    Thurrott, Paul

    2012-01-01

    Tips, tricks, treats, and secrets revealed on Windows 8 Microsoft is introducing a major new release of its Windows operating system, Windows 8, and what better way to learn all its ins and outs than from two internationally recognized Windows experts and Microsoft insiders, authors Paul Thurrott and Rafael Rivera? They cut through the hype to get at useful information you'll not find anywhere else, including what role this new OS plays in a mobile and tablet world. Regardless of your level of knowledge, you'll discover little-known facts about how things work, what's new and different, and h

  11. Programming Windows Azure

    CERN Document Server

    Krishnan, Sriram

    2010-01-01

    Learn the nuts and bolts of cloud computing with Windows Azure, Microsoft's new Internet services platform. Written by a key member of the product development team, this book shows you how to build, deploy, host, and manage applications using Windows Azure's programming model and essential storage services. Chapters in Programming Windows Azure are organized to reflect the platform's buffet of services. The book's first half focuses on how to write and host application code on Windows Azure, while the second half explains all of the options you have for storing and accessing data on the plat

  12. Beginning Windows 8

    CERN Document Server

    Halsey, Mike

    2012-01-01

    Windows 8 has been described by Microsoft as its 'boldest' Windows release ever. Beginning Windows 8 takes you through the new features and helps you get more out of the familiar to reveal the possibilities for this amazing new operating system. You will learn, with non-technical language used throughout, how to get up and running in the new Windows interface, minimize downtime, maximize productivity, and harness the features you never knew existed to take control of your computer and enjoy the peace of mind and excitement that comes with it. From tips and tweaks to easy-to-follow guides and d

  13. Mastering Windows 7 Deployment

    CERN Document Server

    Finn, Aidan; van Surksum, Kenneth

    2011-01-01

    Get professional-level instruction on Windows 7 deployment tools Enterprise-level operating system deployment is challenging and requires knowledge of specific tools. It is expected that Windows 7 will be extensively deployed in businesses worldwide. This comprehensive Sybex guide provides thorough coverage of the Microsoft deployment tools that were specifically created for Windows 7, preparing system administrators, MIS professionals, and corporate programmers to tackle the task effectively.Companies worldwide are expected to deploy Windows 7 as their enterprise operating system; system admi

  14. Least Squares Moving-Window Spectral Analysis.

    Science.gov (United States)

    Lee, Young Jong

    2017-08-01

    Least squares regression is proposed as a moving-windows method for analysis of a series of spectra acquired as a function of external perturbation. The least squares moving-window (LSMW) method can be considered an extended form of the Savitzky-Golay differentiation for nonuniform perturbation spacing. LSMW is characterized in terms of moving-window size, perturbation spacing type, and intensity noise. Simulation results from LSMW are compared with results from other numerical differentiation methods, such as single-interval differentiation, autocorrelation moving-window, and perturbation correlation moving-window methods. It is demonstrated that this simple LSMW method can be useful for quantitative analysis of nonuniformly spaced spectral data with high frequency noise.

  15. Single photon imaging and timing array sensor apparatus and method

    Science.gov (United States)

    Smith, R. Clayton

    2003-06-24

    An apparatus and method are disclosed for generating a three-dimension image of an object or target. The apparatus is comprised of a photon source for emitting a photon at a target. The emitted photons are received by a photon receiver for receiving the photon when reflected from the target. The photon receiver determines a reflection time of the photon and further determines an arrival position of the photon on the photon receiver. An analyzer is communicatively coupled to the photon receiver, wherein the analyzer generates a three-dimensional image of the object based upon the reflection time and the arrival position.

  16. Single particle aerodynamic relaxation time analyzer. [for aerosol pollutants

    Science.gov (United States)

    Mazumder, M. K.; Kirsch, K. J.

    1977-01-01

    An instrument employing a laser Doppler velocimeter and a microphone to measure the phase lag of the motion of aerosol particulates relative to the motion of the fluid medium within an acoustic field is described. The relaxation times and aerodynamic diameters of the particles or droplets are determined in real time from the measured values of phase lag; thus, the size analysis is independent of the electrostatic charges and refractive indices of the particulates. The instrument is suitable for analyzing the aerodynamic size spectrum of atmospheric particulate pollutants with aerodynamic diameters ranging from 0.1 to 10.0 microns.

  17. Vehicle speed prediction via a sliding-window time series analysis and an evolutionary least learning machine: A case study on San Francisco urban roads

    Directory of Open Access Journals (Sweden)

    Ladan Mozaffari

    2015-06-01

    Full Text Available The main goal of the current study is to take advantage of advanced numerical and intelligent tools to predict the speed of a vehicle using time series. It is clear that the uncertainty caused by temporal behavior of the driver as well as various external disturbances on the road will affect the vehicle speed, and thus, the vehicle power demands. The prediction of upcoming power demands can be employed by the vehicle powertrain control systems to improve significantly the fuel economy and emission performance. Therefore, it is important to systems design engineers and automotive industrialists to develop efficient numerical tools to overcome the risk of unpredictability associated with the vehicle speed profile on roads. In this study, the authors propose an intelligent tool called evolutionary least learning machine (E-LLM to forecast the vehicle speed sequence. To have a practical evaluation regarding the efficacy of E-LLM, the authors use the driving data collected on the San Francisco urban roads by a private Honda Insight vehicle. The concept of sliding window time series (SWTS analysis is used to prepare the database for the speed forecasting process. To evaluate the performance of the proposed technique, a number of well-known approaches, such as auto regressive (AR method, back-propagation neural network (BPNN, evolutionary extreme learning machine (E-ELM, extreme learning machine (ELM, and radial basis function neural network (RBFNN, are considered. The performances of the rival methods are then compared in terms of the mean square error (MSE, root mean square error (RMSE, mean absolute percentage error (MAPE, median absolute percentage error (MDAPE, and absolute fraction of variances (R2 metrics. Through an exhaustive comparative study, the authors observed that E-LLM is a powerful tool for predicting the vehicle speed profiles. The outcomes of the current study can be of use for the engineers of automotive industry who have been

  18. Economic resources and remaining single: trends over time

    NARCIS (Netherlands)

    Dykstra, P.A.; Poortman, A.

    2010-01-01

    An influential hypothesis in family research is that having many economic resources decreases women’s and increases men’s rate of entering a union. A more recent hypothesis is that the strength of the association between economic resources and union formation has weakened over time, given decreasing

  19. Economic resources and remaining single : trends over time.

    NARCIS (Netherlands)

    Dykstra, Pearl A.; Poortman, Anne-Rigt

    2010-01-01

    An influential hypothesis in family research is that having many economic resources decreases women’s and increases men’s rate of entering a union. A more recent hypothesis is that the strength of the association between economic resources and union formation has weakened over time, given decreasing

  20. Cavity-Enhanced Real-Time Monitoring of Single-Charge Jumps at the Microsecond Time Scale

    Science.gov (United States)

    Arnold, C.; Loo, V.; Lemaître, A.; Sagnes, I.; Krebs, O.; Voisin, P.; Senellart, P.; Lanco, L.

    2014-04-01

    We use fast coherent reflectivity measurements, in a strongly coupled quantum dot micropillar device, to monitor in real time single-charge jumps at the microsecond time scale. Thanks to the strong enhancement of light-matter interaction inside the cavity, and to a close to shot-noise-limited detection setup, the measurement rate is 5 orders of magnitude faster than with previous optical experiments of direct single-charge sensing with quantum dots. The monitored transitions, identified at any given time with a less than 0.2% error probability, correspond to a carrier being captured and then released by a single material defect. This high-speed technique opens the way for the real-time monitoring of other rapid single quantum events, such as the quantum jumps of a single spin.

  1. Window selection for dual photopeak window scatter correction in Tc-99m imaging

    International Nuclear Information System (INIS)

    Vries, D.J. de; King, M.A.

    1994-01-01

    The width and placement of the windows for the dual photopeak window (DPW) scatter subtraction method for Tc-99m imaging is investigated in order to obtain a method that is stable on a multihead detector system for single photon emission computed tomography (SPECT) and is capable of providing a good scatter estimate for extended objects. For various window pairs, stability and noise were examined with experiments using a SPECT system, while Monte Carlo simulations were used to predict the accuracy of scatter estimates for a variety of objects and to guide the development of regression relations for various window pairs. The DPW method that resulted from this study was implemented with a symmetric 20% photopeak window composed of a 15% asymmetric photopeak window and a 5% lower window abutted at 7 keV below the peak. A power function regression was used to relate the scatter-to-total ratio to the lower window-to-total ratio at each pixel, from which an estimated scatter image was calculated. DPW demonstrated good stability, achieved by abutting the two windows away from the peak. Performance was assessed and compared with Compton window subtraction (CWS). For simulated extended objects, DPW generally produced a less biased scatter estimate than the commonly used CWS method with k = 0.5. In acquisitions of a clinical SPECT phantom, contrast recovery was comparable for both DPW and CWS; however, DPW showed greater visual contrast in clinical SPECT bone studies

  2. Assessing the scientific relevance of a single publication over time

    Directory of Open Access Journals (Sweden)

    Philipp A. Bloching

    2013-09-01

    Full Text Available Quantitatively assessing the scientific relevance of a research paper is challenging for two reasons. Firstly, scientific relevance may change over time, and secondly, it is unclear how to evaluate a recently published paper. The temporally averaged paper-specific impact factor is defined as the yearly average of citations to the paper until now including bonus citations equal to the journal impact factor in the publication year. This new measure subsequently allows relevance rankings and annual updates of all (i.e. both recent and older scientific papers of a department, or even a whole scientific field, on a more objective basis. It can also be used to assess both the average and overall time-dependent scientific relevance of researchers in a specific department or scientific field.

  3. Efficient Windows Collaborative

    Energy Technology Data Exchange (ETDEWEB)

    Nils Petermann

    2010-02-28

    The project goals covered both the residential and commercial windows markets and involved a range of audiences such as window manufacturers, builders, homeowners, design professionals, utilities, and public agencies. Essential goals included: (1) Creation of 'Master Toolkits' of information that integrate diverse tools, rating systems, and incentive programs, customized for key audiences such as window manufacturers, design professionals, and utility programs. (2) Delivery of education and outreach programs to multiple audiences through conference presentations, publication of articles for builders and other industry professionals, and targeted dissemination of efficient window curricula to professionals and students. (3) Design and implementation of mechanisms to encourage and track sales of more efficient products through the existing Window Products Database as an incentive for manufacturers to improve products and participate in programs such as NFRC and ENERGY STAR. (4) Development of utility incentive programs to promote more efficient residential and commercial windows. Partnership with regional and local entities on the development of programs and customized information to move the market toward the highest performing products. An overarching project goal was to ensure that different audiences adopt and use the developed information, design and promotion tools and thus increase the market penetration of energy efficient fenestration products. In particular, a crucial success criterion was to move gas and electric utilities to increase the promotion of energy efficient windows through demand side management programs as an important step toward increasing the market share of energy efficient windows.

  4. The windows method

    DEFF Research Database (Denmark)

    Neighbour, Roger; Larsen, Jan-Helge

    2017-01-01

    through in sequence, each one opening a different viewpoint or window on the case. To experienced tutors, the windows method’s prescriptive structure may at first seem somewhat rigid. However, for learners with less experience of reflection and self-disclosure, it provides the security necessary...

  5. Color Wheel Windows

    Science.gov (United States)

    Leonard, Stephanie

    2012-01-01

    In this article, the author describes a painting and drawing lesson which was inspired by the beautiful circular windows found in cathedrals and churches (also known as "rose windows"). This two-week lesson would reinforce both the concept of symmetry and students' understanding of the color wheel. (Contains 1 online resource.)

  6. Improving performance of single-path code through a time-predictable memory hierarchy

    DEFF Research Database (Denmark)

    Cilku, Bekim; Puffitsch, Wolfgang; Prokesch, Daniel

    2017-01-01

    . The single-path code generation overcomes these problems by generating time-predictable code that has a single execution trace. However, the simplicity of this approach comes at the cost of longer execution times. This paper addresses performance improvements for single-path code. We propose a time......-predictable memory hierarchy with a prefetcher that exploits the predictability of execution traces in single-path code to speed up code execution. The new memory hierarchy reduces both the cache-miss penalty time and the cache-miss rate on the instruction cache. The benefit of the approach is demonstrated through...

  7. Visual merchandising window display

    Directory of Open Access Journals (Sweden)

    Opris (Cas. Stanila M.

    2013-12-01

    Full Text Available Window display plays a major part in the selling strategies; it does not only include the simple display of goods, nowadays it is a form of art, also having the purpose of sustaining the brand image. This article wants to reveal the tools that are essential in creating a fabulous window display. Being a window designer is not an easy job, you have to always think ahead trends, to have a sense of colour, to know how to use light to attract customers in the store after only one glance at the window. The big store window displays are theatre scenes: with expensive backgrounds, special effects and high fashion mannequins. The final role of the displays is to convince customers to enter the store and trigger the purchasing act which is the final goal of the retail activity.

  8. Windows 8 & Office 2010 for dummies

    CERN Document Server

    Rathbone, Andy

    2012-01-01

    Two complete e-books covering Windows and Office for one low price! This unique value-priced e-book set brings together two bestselling For Dummies books in a single e-book file. Including a comprehensive table of contents and the full text of each book, complete with cover, this e-book set gives you in-depth information on the leading PC productivity tools: Windows 8 and Office 2010. Best of all, you'll pay less than the cost of each book purchased separately. You'll get the complete text of: Windows 8 For Dummies, which covers The core component

  9. Cascaded Window Memoization for Medical Imaging

    OpenAIRE

    Khalvati , Farzad; Kianpour , Mehdi; Tizhoosh , Hamid ,

    2011-01-01

    Part 12: Medical Applications of ANN and Ethics of AI; International audience; Window Memoization is a performance improvement technique for image processing algorithms. It is based on removing computational redundancy in an algorithm applied to a single image, which is inherited from data redundancy in the image. The technique employs a fuzzy reuse mechanism to eliminate unnecessary computations. This paper extends the window memoization technique such that in addition to exploiting the data...

  10. Single-molecule stochastic times in a reversible bimolecular reaction.

    Science.gov (United States)

    Keller, Peter; Valleriani, Angelo

    2012-08-28

    In this work, we consider the reversible reaction between reactants of species A and B to form the product C. We consider this reaction as a prototype of many pseudobiomolecular reactions in biology, such as for instance molecular motors. We derive the exact probability density for the stochastic waiting time that a molecule of species A needs until the reaction with a molecule of species B takes place. We perform this computation taking fully into account the stochastic fluctuations in the number of molecules of species B. We show that at low numbers of participating molecules, the exact probability density differs from the exponential density derived by assuming the law of mass action. Finally, we discuss the condition of detailed balance in the exact stochastic and in the approximate treatment.

  11. Selecting windows for energy efficiency

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-05-01

    New window technologies have increased energy benefits and comfort, and have provided more practical options for consumers. This selection guide will help homeowners, architects, and builders take advantage of the expanding window market. The guide contains three sections: an explanation of energy-related window characteristics, a discussion of window energy performance ratings, and a convenient checklist for window selection.

  12. The Efficient Windows Collaborative

    Energy Technology Data Exchange (ETDEWEB)

    Petermann, Nils

    2006-03-31

    The Efficient Windows Collaborative (EWC) is a coalition of manufacturers, component suppliers, government agencies, research institutions, and others who partner to expand the market for energy efficient window products. Funded through a cooperative agreement with the U.S. Department of Energy, the EWC provides education, communication and outreach in order to transform the residential window market to 70% energy efficient products by 2005. Implementation of the EWC is managed by the Alliance to Save Energy, with support from the University of Minnesota and Lawrence Berkeley National Laboratory.

  13. Rails on Windows

    CERN Document Server

    Hibbs, Curt

    2007-01-01

    It's no secret that the entire Ruby onRails core team uses OS X as their preferreddevelopment environment. Becauseof this, it is very easy to findauthoritative information on the webabout using Rails on OS X. But the truthis that Windows developers using Railsprobably outnumber those using otherplatforms. A Windows development environmentcan be just as productive asany other platform. This is a guide to developing with Rubyon Rails under Windows. It won't teachyou how to write Ruby on Rails web applications,but it will show you what toolsto use and how to set them up to createa complete Rail

  14. Windows 8 simplified

    CERN Document Server

    McFedries, Paul

    2012-01-01

    The easiest way for visual learners to get started with Windows 8 The popular Simplified series makes visual learning easier than ever, and with more than 360,000 copies sold, previous Windows editions are among the bestselling Visual books. This guide goes straight to the point with easy-to-follow, two-page tutorials for each task. With full-color screen shots and step-by-step directions, it gets beginners up and running on the newest version of Windows right away. Learn to work with the new interface and improved Internet Explorer, manage files, share your computer, and much more. Perfect fo

  15. Windows 95 Beslutningsguide

    DEFF Research Database (Denmark)

    Sørensen, Jens Otto

    1996-01-01

    Mange virksomheder der bruger pc'er står netop nu over for valget: Skal vi fortsætte med DOS/Windows 3.x som operativsystem, eller skal vi skifte til efterfølgeren Windows 95? Skal vi/kan vi skifte successivt, eller skal det være en "alt eller intet beslutning". Hvornår er det rigtige tidspunkt...... at skifte? Denne artikel vil forsøge at give en baggrundsviden om Windows 95, der kan hjælpe virksomhederne igennem denne beslutningsfase....

  16. Windows 7 resource kit

    CERN Document Server

    Northrup, Tony; Honeycutt, Jerry; Wilson, Ed

    2009-01-01

    In-depth and comprehensive, this RESOURCE KIT delivers the information you need to administer your Windows 7 system. You get authoritative technical guidance from those who know the technology best-Microsoft Most Valuable Professionals (MVPs) and the Windows 7 product team-along with essential scripts and resources. In addition, "Direct from the Source" sidebars offer deep insights and troubleshooting tips from the Windows 7 team. Get expert guidance on how to: Use Microsoft Deployment Toolkit best practices and tools. Plan user-state migration and test application compatibility.

  17. Destiny's Earth Observation Window

    Science.gov (United States)

    2002-01-01

    Astronaut Michael J. Bloomfield, STS-110 mission commander, looks through the Earth observation window in the Destiny laboratory aboard the International Space Station (ISS). The STS-110 mission prepared the ISS for future spacewalks by installing and outfitting the S0 (S-zero) truss and the Mobile Transporter. The 43-foot-long S0 Truss, weighing in at 27,000 pounds, was the first of 9 segments that will make up the Station's external framework that will eventually stretch 356 feet (109 meters), or approximately the length of a football field. This central truss segment also includes a flatcar called the Mobile Transporter and rails that will become the first 'space railroad,' which will allow the Station's robotic arm to travel up and down the finished truss for future assembly and maintenance. The completed truss structure will hold solar arrays and radiators to provide power and cooling for additional international research laboratories from Japan and Europe that will be attached to the Station. Milestones of the STS-110 mission included the first time the ISS robotic arm was used to maneuver spacewalkers around the Station and marked the first time all spacewalks were based out of the Station's Quest Airlock. It was also the first Shuttle to use three Block II Main Engines. The Space Shuttle Orbiter Atlantis, STS-110 mission, was launched April 8, 2002 and returned to Earth April 19, 2002.

  18. Windows 10 Technical Preview

    OpenAIRE

    Jyväsjärvi, Teppo

    2015-01-01

    Tässä opinnäytetyössä tutustaan uuden kesällä 2015 virallisesti julkaistavan Windows 10 -käyttöjärjestelmän Technical Preview -kehitysversioon. Ensimmäinen Technical Preview -versio julkaistiin syksyllä 2014. Opinnäytetyössä tutustaan Windows 10:n uusin ominaisuuksiin ja tehdään vertailua aiemman Windows 8.1 -version kanssa. Työssä Windows 10 Technical Preview asennetaan virtuaalikoneelle, käydään läpi asennuksen eri vaiheet sekä suurimmat muutokset käyttöliittymässä ja sovelluksissa. Op...

  19. SAF for Windows

    DEFF Research Database (Denmark)

    Hansen, Timme

    2001-01-01

    SAF for Windows er et computerprogram til parametrisk konstruktion af translationsskaller. Skaloverfladernes tredimensionelle, facetterede form fremkommer ved en kombination af to todimensionelle formbestemmende kurver, som kan vælges og redigeres af brugeren. Programmet kan udfolde de genererede...

  20. Diffusion escape through a cluster of small absorbing windows

    Energy Technology Data Exchange (ETDEWEB)

    Holcman, D [Department of Mathematics, Weizmann Institute of Science, Rehovot 76100 (Israel); Schuss, Z [Department of Mathematics, Tel-Aviv University, Tel-Aviv 69978 (Israel)

    2008-04-18

    We study the first eigenvalue of the Laplace equation in a bounded domain in R{sup d} (d=2,3) with mixed Neumann-Dirichlet (Zaremba) boundary conditions. The Neumann condition is imposed on most of the boundary and the Dirichlet boundary consists of a cluster of small windows. When the windows are well separated the first eigenvalue is asymptotically the sum of eigenvalues of mixed problems with a single Dirichlet window. However, when two or more Dirichlet windows cluster tightly together they interact nonlinearly. We compare our asymptotic approximation of the eigenvalue to the escape rate of simulated Brownian particles through the small windows.

  1. Windows Security patch required

    CERN Multimedia

    3004-01-01

    This concerns Windows PCs (XP, 2000, NT) which are NOT centrally managed at CERN for security patches, e.g. home PCs, experiment PCs, portables,... A security hole which can give full privileges on Windows systems needs to be URGENTLY patched. Details of the security hole and hotfix are at: http://cern.ch/it-div/news/hotfix-MS03-026.asp http://www.microsoft.com/technet/security/bulletin/MS03-026.asp

  2. Delineating the conformal window

    DEFF Research Database (Denmark)

    Frandsen, Mads Toudal; Pickup, Thomas; Teper, Michael

    2011-01-01

    We identify and characterise the conformal window in gauge theories relevant for beyond the standard model building, e.g. Technicolour, using the criteria of metric confinement and causal analytic couplings, which are known to be consistent with the phase diagram of supersymmetric QCD from Seiberg...... duality. Using these criteria we find perturbation theory to be consistent throughout the predicted conformal window for several of these gauge theories and we discuss recent lattice results in the light of our findings....

  3. Windows Security patch required

    CERN Multimedia

    2003-01-01

    This concerns Windows PCs (XP, 2000, NT) which are NOT centrally managed at CERN for security patches, e.g. home PCs, experiment PCs, portables, ... A security hole which can give full privileges on Windows systems needs to be URGENTLY patched. Details of the security hole and hotfix are at: http://cern.ch/it-div/news/hotfix-MS03-026.asp http://www.microsoft.com/technet/security/bulletin/MS03-026.asp

  4. Windows Security patch required

    CERN Multimedia

    2003-01-01

    This concerns Windows PCs (XP, 2000, NT) which are NOT centrally managed at CERN for security patches, e.g. home PCs, experiment PCs, portables,... A security hole which can give full privileges on Windows systems needs to be URGENTLY patched. Details of the security hole and hotfix are at: http://cern.ch/it-div/news/hotfix-MS03-026.asp http://www.microsoft.com/technet/security/bulletin/MS03-026.asp

  5. Multi-gamma windows coincidence method

    International Nuclear Information System (INIS)

    Liu Yunpeng

    1998-10-01

    In 4πβ-γ coincidence measurement of radioactivity, efficiency extrapolation method has been applied for a long time. According to the principle developed by P. J. Campion, usually a single gamma window is selected, and also an useful assumption is introduced that efficiency of individual β-branch are linearly related to one another, resulting in a simply linear efficiency function. Generally, the extrapolation curve is not linear so in practice an unspecified efficiency function which is usually defined simply as a polynomial in N c /N γ is introduced. Because of the unspecification of the efficiency function, systematic errors may arise theoretically from which the polynominal function is either inaccurate or unsuitable for extrapolation. To solve this problem, a new method, which is called multi-gamma windows coincidence method is proposed, and a new linear extrapolation equation based on average β efficiency is strictly derived from the basic coincidence equations with the least approximation. Theoretically, this method is applicable to any simple or complex decay (except pure β decay and some decay with long life metastable energy level) with minimum systematic errors

  6. Infecting Windows, Linux & Mac in one go

    CERN Multimedia

    Computer Security Team

    2012-01-01

    Still love bashing on Windows as you believe it is an insecure operating system? Hold on a second! Just recently, a vulnerability has been published for Java 7.   It affects Windows/Linux PCs and Macs, Internet Explorer, Safari and Firefox. In fact, it affects all computers that have enabled the Java 7 plug-in in their browser (Java 6 and earlier is not affected). Once you visit a malicious website (and there are plenty already out in the wild), your computer is infected… That's "Game Over" for you.      And this is not the first time. For a while now, attackers have not been targeting the operating system itself, but rather aiming at vulnerabilities inherent in e.g. your Acrobat Reader, Adobe Flash or Java programmes. All these are standard plug-ins added into your favourite web browser which make your web-surfing comfortable (or impossible when you un-install them). A single compromised web-site, however, is sufficient to prob...

  7. High Performance Window Retrofit

    Energy Technology Data Exchange (ETDEWEB)

    Shrestha, Som S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hun, Diana E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Desjarlais, Andre Omer [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2013-12-01

    The US Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) and Traco partnered to develop high-performance windows for commercial building that are cost-effective. The main performance requirement for these windows was that they needed to have an R-value of at least 5 ft2∙ F∙h/Btu. This project seeks to quantify the potential energy savings from installing these windows in commercial buildings that are at least 20 years old. To this end, we are conducting evaluations at a two-story test facility that is representative of a commercial building from the 1980s, and are gathering measurements on the performance of its windows before and after double-pane, clear-glazed units are upgraded with R5 windows. Additionally, we will use these data to calibrate EnergyPlus models that we will allow us to extrapolate results to other climates. Findings from this project will provide empirical data on the benefits from high-performance windows, which will help promote their adoption in new and existing commercial buildings. This report describes the experimental setup, and includes some of the field and simulation results.

  8. Quasi-Real Time Estimation of Angular Kinematics Using Single-Axis Accelerometers

    Directory of Open Access Journals (Sweden)

    Angelo Cappello

    2013-01-01

    Full Text Available In human movement modeling, the problem of multi-link kinematics estimation by means of inertial measurement units has been investigated by several authors through efficient sensor fusion algorithms. In this perspective a single inertial measurement unit per link is required. This set-up is not cost-effective compared with a solution in which a single-axis accelerometer per link is used. In this paper, a novel fast technique is presented for the estimation of the sway angle in a multi-link chain by using a single-axis accelerometer per segment and by setting the boundary conditions through an ad hoc algorithm. The technique, based on the windowing of the accelerometer output, was firstly tested on a mechanical arm equipped with a single-axis accelerometer and a reference encoder. The technique is then tested on a subject performing a squat task for the knee flexion-extension angle evaluation by using two single-axis accelerometers placed on the thigh and shank segments, respectively. A stereo-photogrammetric system was used for validation. RMSEs (mean ± std are 0.40 ± 0.02° (mean peak-to-peak range of 147.2 ± 4.9° for the mechanical inverted pendulum and 1.01 ± 0.11° (mean peak-to-peak range of 59.29 ± 2.02° for the knee flexion-extension angle. Results obtained in terms of RMSE were successfully compared with an Extended Kalman Filter applied to an inertial measurement unit. These results suggest the usability of the proposed algorithm in several fields, from automatic control to biomechanics, and open new opportunities to increase the accuracy of the existing tools for orientation evaluation.

  9. Quasi-real time estimation of angular kinematics using single-axis accelerometers.

    Science.gov (United States)

    Caroselli, Alessio; Bagalà, Fabio; Cappello, Angelo

    2013-01-15

    In human movement modeling, the problem of multi-link kinematics estimation by means of inertial measurement units has been investigated by several authors through efficient sensor fusion algorithms. In this perspective a single inertial measurement unit per link is required. This set-up is not cost-effective compared with a solution in which a single-axis accelerometer per link is used. In this paper, a novel fast technique is presented for the estimation of the sway angle in a multi-link chain by using a single-axis accelerometer per segment and by setting the boundary conditions through an ad hoc algorithm. The technique, based on the windowing of the accelerometer output, was firstly tested on a mechanical arm equipped with a single-axis accelerometer and a reference encoder. The technique is then tested on a subject performing a squat task for the knee flexion-extension angle evaluation by using two single-axis accelerometers placed on the thigh and shank segments, respectively. A stereo-photogrammetric system was used for validation. RMSEs (mean ± std) are 0.40 ± 0.02° (mean peak-to-peak range of 147.2 ± 4.9°) for the mechanical inverted pendulum and 1.01 ± 0.11° (mean peak-to-peak range of 59.29 ± 2.02°) for the knee flexion-extension angle. Results obtained in terms of RMSE were successfully compared with an Extended Kalman Filter applied to an inertial measurement unit. These results suggest the usability of the proposed algorithm in several fields, from automatic control to biomechanics, and open new opportunities to increase the accuracy of the existing tools for orientation evaluation.

  10. Thin Film & Deposition Systems (Windows)

    Data.gov (United States)

    Federal Laboratory Consortium — Coating Lab: Contains chambers for growing thin film window coatings. Plasma Applications Coating Lab: Contains chambers for growing thin film window coatings. Solar...

  11. Lung Injury; Relates to Real-Time Endoscopic Monitoring of Single Cells Respiratory Health in Lung

    Science.gov (United States)

    2017-09-01

    AWARD NUMBER: W81XWH-16-1-0253 TITLE: Lung Injury; Relates to Real- Time Endoscopic Monitoring of Single Cells Respiratory Health in Lung...response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and...Sep 2016 - 31 Aug 2017 5a. CONTRACT NUMBER 4. TITLE AND SUBTITLE Lung Injury; Relates to Real- Time Endoscopic Monitoring of Single Cells Respiratory

  12. Efficient use of single molecule time traces to resolve kinetic rates, models and uncertainties

    Science.gov (United States)

    Schmid, Sonja; Hugel, Thorsten

    2018-03-01

    Single molecule time traces reveal the time evolution of unsynchronized kinetic systems. Especially single molecule Förster resonance energy transfer (smFRET) provides access to enzymatically important time scales, combined with molecular distance resolution and minimal interference with the sample. Yet the kinetic analysis of smFRET time traces is complicated by experimental shortcomings—such as photo-bleaching and noise. Here we recapitulate the fundamental limits of single molecule fluorescence that render the classic, dwell-time based kinetic analysis unsuitable. In contrast, our Single Molecule Analysis of Complex Kinetic Sequences (SMACKS) considers every data point and combines the information of many short traces in one global kinetic rate model. We demonstrate the potential of SMACKS by resolving the small kinetic effects caused by different ionic strengths in the chaperone protein Hsp90. These results show an unexpected interrelation between conformational dynamics and ATPase activity in Hsp90.

  13. Window modelling in Syrthes

    Energy Technology Data Exchange (ETDEWEB)

    Manias, V.; Peniguel, C. [Electricite de France, 78 - Chatou (France); Rupp, I. [Simulog, N3S, Estet, Simail, 78 - Saint Quentin en Yvelyne (France)

    1997-12-31

    Developments to take into account windows from a thermal point of view have been implemented in SYRTHES. Windows are discretized along their lateral surfaces in several independent patches. Then a one-dimensional analytical model solves the semi-transparent radiation and conduction problem occurring across the window for each patch. The spectral dependence of the absorption coefficient (`non grey` medium) is taken into account through a multi-band model. This window model is coupled with the conduction and radiation capabilities already existing in SYRTHES. When convection is taking place, it is handled by ESTET. This development will be applied to an infra-red system designed to dry paper. The simplified test case presented here consists very schematically in two cavities separated by a window (vitro-ceramic). The top cavity contains a very hot tungsten wire (the infrared source) surrounded by a tube made of quartz. The bottom cavity is where the fast moving sheet of paper will be located. Of Course the real geometry is much more complex. (authors)

  14. Single Sources in the Low-Frequency Gravitational Wave Sky:properties and time to detection by pulsar timing arrays

    Science.gov (United States)

    Kelley, Luke Zoltan; Blecha, Laura; Hernquist, Lars; Sesana, Alberto; Taylor, Stephen R.

    2018-03-01

    We calculate the properties, occurrence rates and detection prospects of individually resolvable `single sources' in the low frequency gravitational wave (GW) spectrum. Our simulations use the population of galaxies and massive black hole binaries from the Illustris cosmological hydrodynamic simulations, coupled to comprehensive semi-analytic models of the binary merger process. Using mock pulsar timing arrays (PTA) with, for the first time, varying red-noise models, we calculate plausible detection prospects for GW single sources and the stochastic GW background (GWB). Contrary to previous results, we find that single sources are at least as detectable as the GW background. Using mock PTA, we find that these `foreground' sources (also `deterministic'/`continuous') are likely to be detected with ˜ 20 yr total observing baselines. Detection prospects, and indeed the overall properties of single sources, are only moderately sensitive to binary evolution parameters—namely eccentricity & environmental coupling, which can lead to differences of ˜ 5 yr in times to detection. Red noise has a stronger effect, roughly doubling the time to detection of the foreground between a white-noise only model (˜ 10 - 15 yr) and severe red noise (˜20 - 30 yr). The effect of red noise on the GWB is even stronger, suggesting that single source detections may be more robust. We find that typical signal-to-noise ratios for the foreground peak near f = 0.1 yr-1, and are much less sensitive to the continued addition of new pulsars to PTA.

  15. A windowing and mapping strategy for gear tooth fault detection of a planetary gearbox

    Science.gov (United States)

    Liang, Xihui; Zuo, Ming J.; Liu, Libin

    2016-12-01

    When there is a single cracked tooth in a planet gear, the cracked tooth is enmeshed for very short time duration in comparison to the total time of a full revolution of the planet gear. The fault symptom generated by the single cracked tooth may be very weak. This study aims to develop a windowing and mapping strategy to interpret the vibration signal of a planetary gear at the tooth level. The fault symptoms generated by a single cracked tooth of the planet gear of interest can be extracted. The health condition of the planet gear can be assessed by comparing the differences among the signals of all teeth of the planet gear. The proposed windowing and mapping strategy is tested with both simulated vibration signals and experimental vibration signals. The tooth signals can be successfully decomposed and a single tooth fault on a planet gear can be effectively detected.

  16. Conformational analysis of single perfluoroalkyl chains by single-molecule real-time transmission electron microscopic imaging.

    Science.gov (United States)

    Harano, Koji; Takenaga, Shinya; Okada, Satoshi; Niimi, Yoshiko; Yoshikai, Naohiko; Isobe, Hiroyuki; Suenaga, Kazu; Kataura, Hiromichi; Koshino, Masanori; Nakamura, Eiichi

    2014-01-08

    Whereas a statistical average of molecular ensembles has been the conventional source of information on molecular structures, atomic resolution movies of single organic molecules obtained by single-molecule real-time transmission electron microscopy have recently emerged as a new tool to study the time evolution of the structures of individual molecules. The present work describes a proof-of-principle study of the determination of the conformation of each C-C bond in single perfluoroalkyl fullerene molecules encapsulated in a single-walled carbon nanotube (CNT) as well as those attached to the outer surface of a carbon nanohorn (CNH). Analysis of 82 individual molecules in CNTs under a 120 kV electron beam indicated that 6% of the CF2-CF2 bonds and about 20% of the CH2-CH2 bonds in the corresponding hydrocarbon analogue are in the gauche conformation. This comparison qualitatively matches the known conformational data based on time- and molecular-average as determined for ensembles. The transmission electron microscopy images also showed that the molecules entered the CNTs predominantly in one orientation. The molecules attached on a CNH surface moved more freely and exhibited more diverse conformation than those in a CNT, suggesting the potential applicability of this method for the determination of the dynamic shape of flexible molecules and of detailed conformations. We observed little sign of any decomposition of the specimen molecules, at least up to 10(7) e·nm(-2) (electrons/nm(2)) at 120 kV acceleration voltage. Decomposition of CNHs under irradiation with a 300 kV electron beam was suppressed by cooling to 77 K, suggesting that the decomposition is a chemical process. Several lines of evidence suggest that the graphitic substrate and the attached molecules are very cold.

  17. Development of vacuum barrier windows for high power gyrotrons

    International Nuclear Information System (INIS)

    Shimozuma, Takashi

    1997-01-01

    Problems in the realization of vacuum barrier windows for 1MW CW gyrotrons are reviewed from the viewpoint of removing heat generation in the window materials. The merits and demerits of various window structures currently in use or under proposal are explained in detail. The design of a multiple disk window, including RF design and thermal stress analysis, is also described. As an example of a recent successful window structure, the experimental results of a forced gas-cooled single disk window with low loss silicon nitride composite are presented. By this window structure, 130kW CW (8kW/cm 2 ) transmission was achieved with an effective diameter of only 88.9 mm. (author)

  18. Online evolution reconstruction from a single measurement record with random time intervals for quantum communication

    Science.gov (United States)

    Zhou, Hua; Su, Yang; Wang, Rong; Zhu, Yong; Shen, Huiping; Pu, Tao; Wu, Chuanxin; Zhao, Jiyong; Zhang, Baofu; Xu, Zhiyong

    2017-10-01

    Online reconstruction of a time-variant quantum state from the encoding/decoding results of quantum communication is addressed by developing a method of evolution reconstruction from a single measurement record with random time intervals. A time-variant two-dimensional state is reconstructed on the basis of recovering its expectation value functions of three nonorthogonal projectors from a random single measurement record, which is composed from the discarded qubits of the six-state protocol. The simulated results prove that our method is robust to typical metro quantum channels. Our work extends the Fourier-based method of evolution reconstruction from the version for a regular single measurement record with equal time intervals to a unified one, which can be applied to arbitrary single measurement records. The proposed protocol of evolution reconstruction runs concurrently with the one of quantum communication, which can facilitate the online quantum tomography.

  19. Real-time visualization of intracellular hydrodynamics in single living cells

    NARCIS (Netherlands)

    Potma, Eric O.; Boeij, Wim P. de; Haastert, Peter J.M. van; Wiersma, Douwe A.

    2001-01-01

    Intracellular water concentrations in single living cells were visualized by nonlinear coherent anti-Stokes Raman scattering (CARS) microscopy. In combination with isotopic exchange measurements, CARS microscopy allowed the real-time observation of transient intracellular hydrodynamics at a high

  20. Adaptive Liquid Crystal Windows

    Energy Technology Data Exchange (ETDEWEB)

    Taheri, Bahman; Bodnar, Volodymyr

    2011-12-31

    Energy consumption by private and commercial sectors in the U.S. has steadily grown over the last decade. The uncertainty in future availability of imported oil, on which the energy consumption relies strongly, resulted in a dramatic increase in the cost of energy. About 20% of this consumption are used to heat and cool houses and commercial buildings. To reduce dependence on the foreign oil and cut down emission of greenhouse gases, it is necessary to eliminate losses and reduce total energy consumption by buildings. To achieve this goal it is necessary to redefine the role of the conventional windows. At a minimum, windows should stop being a source for energy loss. Ideally, windows should become a source of energy, providing net gain to reduce energy used to heat and cool homes. It is possible to have a net energy gain from a window if its light transmission can be dynamically altered, ideally electronically without the need of operator assistance, providing optimal control of the solar gain that varies with season and climate in the U.S. In addition, the window must not require power from the building for operation. Resolution of this problem is a societal challenge and of national interest and will have a broad global impact. For this purpose, the year-round, allclimate window solution to provide an electronically variable solar heat gain coefficient (SHGC) with a wide dynamic range is needed. AlphaMicron, Inc. (AMI) developed and manufactured 1ft × 1ft prototype panels for the world’s first auto-adjusting Adaptive Liquid Crystal Windows (ALCWs) that can operate from sunlight without the need for external power source and demonstrate an electronically adjustable SHGC. This novel windows are based on AlphaMicron’s patented e-Tint® technology, a guesthost liquid crystal system implemented on flexible, optically clear plastic films. This technology is suitable both for OEM and aftermarket (retro-fitting) lamination to new and existing windows. Low level of

  1. Occupants' window opening behaviour

    DEFF Research Database (Denmark)

    Fabi, Valentina; Andersen, Rune Korsholm; Corgnati, Stefano

    2012-01-01

    systems is proposed, based on studies presented in literature and a general process leading to the effects on energy consumptions is identified.Existing studies on the topic of window opening behaviour are highlighted and a theoretical framework to deal with occupants' interactions with building controls......, aimed at improving or maintaining the preferred indoor environmental conditions, is elaborated. This approach is used to look into the drivers for the actions taken by the occupants (windows opening and closing) and to investigate the existing models in literature of these actions for both residential...... and office buildings. The analysis of the literature highlights how a shared approach on identifying the driving forces for occupants' window opening and closing behaviour has not yet been reached. However, the reporting of variables found not to be drivers may reveal contradictions in the obtained results...

  2. Impact of three window configurations on daylight conditions

    DEFF Research Database (Denmark)

    Dubois, Marie-Claude; Sørensen, Karl Grau; Traberg-Borup, Steen

    The report describes the results of a pilot study on daylight conditions in simple rooms of residential buildings. As a tool for the analyses the Radiance Lighting Simulating System was used to simulate one room with three different window configurations, a vertical window, a dormer window......, and a roof window. The simulations were performed for overcast sky conditions and under one sunny sky, for two different times of the day. The study shows that the window configuration affects the daylight conditions (distribution and intensity) significantly. The roof window results in a higher (average......) daylight factor on a horizontal plane, i.e. more than twice as high compared with the vertical window, and more than triple as high compared with the dormer window....

  3. Windows 8.1 bible

    CERN Document Server

    Boyce, Jim; Tidrow, Rob

    2014-01-01

    Windows 8.1 coverage that goes above and beyond all competitors? Serving as an evolutionary update to Windows 8, Windows 8.1 provides critical changes to parts of Windows 8, such as greater customization of the interface and boot operations, return of a 'start button' that reveals apps, greater integration between the two interfaces, and updates to apps. Weighing in at nearly 1000 pages, Windows 8.1 Bible provides deeper Windows insight than any other book on the market. It's valuable for both professionals needing a guide to the nooks and crannies of Windows and regular users wanting a wide

  4. Windows Deployment Services : Esiasennuspalvelin

    OpenAIRE

    Ahonen, Arto

    2010-01-01

    Opinnäytetyöni aiheena on Windows Deployment Services, jonka tarkoituksena on toimia esiasennus-palvelimena Windows-käyttöjärjestelmien levykuvien jakamiseen sekä asentamiseen. Opinnäytetyö to-teutettiin yhteistyössä Concept.10 IT:n ja tuotannon kanssa. Concept.10:n tuotannon lähtökohtana on valmistaa ja asentaa Suomen markkinoille tietokonelaitteistoja ohjelmistoineen ja tukipalveluineen. Tuo-tantoon olennaisena osana kuuluu esiasennuspalvelin, jolla voidaan asentaa useita tietokoneita samaa...

  5. Microsoft Windows networking essentials

    CERN Document Server

    Gibson, Darril

    2011-01-01

    The core concepts and technologies of Windows networking Networking can be a complex topic, especially for those new to the field of IT. This focused, full-color book takes a unique approach to teaching Windows networking to beginners by stripping down a network to its bare basics, thereby making each topic clear and easy to understand. Focusing on the new Microsoft Technology Associate (MTA) program, this book pares down to just the essentials, showing beginners how to gain a solid foundation for understanding networking concepts upon which more advanced topics and technologies can be built.

  6. Windows Azure Platform

    CERN Document Server

    Redkar, Tejaswi

    2010-01-01

    The Azure Services Platform is a brand-new cloud-computing technology from Microsoft. It is composed of four core components-Windows Azure, .NET Services, SQL Services, and Live Services-each with a unique role in the functioning of your cloud service. It is the goal of this book to show you how to use these components, both separately and together, to build flawless cloud services. At its heart Windows Azure Platform is a down-to-earth, code-centric book. This book aims to show you precisely how the components are employed and to demonstrate the techniques and best practices you need to know

  7. Microsoft Windows Security Essentials

    CERN Document Server

    Gibson, Darril

    2011-01-01

    Windows security concepts and technologies for IT beginners IT security can be a complex topic, especially for those new to the field of IT. This full-color book, with a focus on the Microsoft Technology Associate (MTA) program, offers a clear and easy-to-understand approach to Windows security risks and attacks for newcomers to the world of IT. By paring down to just the essentials, beginners gain a solid foundation of security concepts upon which more advanced topics and technologies can be built. This straightforward guide begins each chapter by laying out a list of topics to be discussed,

  8. "Stained Glass" Landscape Windows

    Science.gov (United States)

    Vannata, Janine

    2008-01-01

    Both adults and children alike marvel at the grand vivid stained-glass windows created by American artist Louis Comfort Tiffany. Today he is commonly recognized as one of America's most influential designers and artists throughout the last nineteenth and early twentieth century. In the lesson described in this article, students created their own…

  9. Exploring Shop Window Displays

    Science.gov (United States)

    Christopoulou, Martha

    2011-01-01

    Using visual resources from everyday life in art lessons can enrich students' knowledge about the creation of visual images, artifacts, and sites, and develop their critical understanding about the cultural impact of these images and their effects on people's lives. Through examining an exhibition in the windows of Selfridges department store in…

  10. SINCERITIES: Inferring gene regulatory networks from time-stamped single cell transcriptional expression profiles.

    Science.gov (United States)

    Papili Gao, Nan; Ud-Dean, S M Minhaz; Gandrillon, Olivier; Gunawan, Rudiyanto

    2017-09-14

    Single cell transcriptional profiling opens up a new avenue in studying the functional role of cell-to-cell variability in physiological processes. The analysis of single cell expression profiles creates new challenges due to the distributive nature of the data and the stochastic dynamics of gene transcription process. The reconstruction of gene regulatory networks (GRNs) using single cell transcriptional profiles is particularly challenging, especially when directed gene-gene relationships are desired. We developed SINCERITIES (SINgle CEll Regularized Inference using TIme-stamped Expression profileS) for the inference of GRNs from single cell transcriptional profiles. We focused on time-stamped cross-sectional expression data, commonly generated from transcriptional profiling of single cells collected at multiple time points after cell stimulation. SINCERITIES recovers directed regulatory relationships among genes by employing regularized linear regression (ridge regression), using temporal changes in the distributions of gene expressions. Meanwhile, the modes of the gene regulations (activation and repression) come from partial correlation analyses between pairs of genes. We demonstrated the efficacy of SINCERITIES in inferring GRNs using in silico time-stamped single cell expression data and single cell transcriptional profiles of THP-1 monocytic human leukemia cells. The case studies showed that SINCERITIES could provide accurate GRN predictions, significantly better than other GRN inference algorithms such as TSNI, GENIE3 and JUMP3. Moreover, SINCERITIES has a low computational complexity and is amenable to problems of extremely large dimensionality. Finally, an application of SINCERITIES to single cell expression data of T2EC chicken erythrocytes pointed to BATF as a candidate novel regulator of erythroid development. The MATLAB and R version of SINCERITIES is freely available from the following websites: http://www.cabsel.ethz.ch/tools/sincerities.html and

  11. A test of multiple correlation temporal window characteristic of non-Markov processes

    Science.gov (United States)

    Arecchi, F. T.; Farini, A.; Megna, N.

    2016-03-01

    We introduce a sensitive test of memory effects in successive events. The test consists of a combination K of binary correlations at successive times. K decays monotonically from K = 1 for uncorrelated events as a Markov process. For a monotonic memory fading, K1 temporal window in cognitive tasks consisting of the visual identification of the front face of the Necker cube after a previous presentation of the same. We speculate that memory effects provide a temporal window with K>1 and this experiment could be a possible first step towards a better comprehension of this phenomenon. The K>1 behaviour is maximal at an inter-measurement time τ around 2s with inter-subject differences. The K>1 persists over a time window of 1s around τ; outside this window the K1 window in pairs of successive perceptions suggests that, at variance with single visual stimuli eliciting a suitable response, a pair of stimuli shortly separated in time displays mutual correlations.

  12. Regularity of Dual Gabor Windows

    Directory of Open Access Journals (Sweden)

    Ole Christensen

    2013-01-01

    Full Text Available We present a construction of dual windows associated with Gabor frames with compactly supported windows. The size of the support of the dual windows is comparable to that of the given window. Under certain conditions, we prove that there exist dual windows with higher regularity than the canonical dual window. On the other hand, there are cases where no differentiable dual window exists, even in the overcomplete case. As a special case of our results, we show that there exists a common smooth dual window for an interesting class of Gabor frames. In particular, for any value of K∈ℕ, there is a smooth function h which simultaneously is a dual window for all B-spline generated Gabor frames {EmbTnBN(x/2}m,n∈ℕ for B-splines BN of order N=1,…,2K+1 with a fixed and sufficiently small value of b.

  13. Time-gated single-photon detection module with 110 ps transition time and up to 80 MHz repetition rate

    Energy Technology Data Exchange (ETDEWEB)

    Buttafava, Mauro, E-mail: mauro.buttafava@polimi.it; Boso, Gianluca; Ruggeri, Alessandro; Tosi, Alberto [Politecnico di Milano, Dipartimento di Elettronica, Informazione e Bioingegneria, Piazza Leonardo Da Vinci 32, 20133 Milano (Italy); Dalla Mora, Alberto [Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo Da Vinci 32, 20133 Milano (Italy)

    2014-08-15

    We present the design and characterization of a complete single-photon counting module capable of time-gating a silicon single-photon avalanche diode with ON and OFF transition times down to 110 ps, at repetition rates up to 80 MHz. Thanks to this sharp temporal filtering of incoming photons, it is possible to reject undesired strong light pulses preceding (or following) the signal of interest, allowing to increase the dynamic range of optical acquisitions up to 7 decades. A complete experimental characterization of the module highlights its very flat temporal response, with a time resolution of the order of 30 ps. The instrument is fully user-configurable via a PC interface and can be easily integrated in any optical setup, thanks to its small and compact form factor.

  14. A 30 ps Timing Resolution for Single Photons with Multi-pixel Burle MCP-PMT

    Energy Technology Data Exchange (ETDEWEB)

    Va' vra, J.; Benitez, J.; Coleman, J.; Leith, D.W.G.S.; Mazaheri, G.; Ratcliff, B.; Schwiening, J.; /SLAC

    2006-07-05

    We have achieved {approx}30 psec single-photoelectron and {approx}12ps for multi-photoelectron timing resolution with a new 64 pixel Burle MCP-PMT with 10 micron microchannel holes. We have also demonstrated that this detector works in a magnetic field of 15kG, and achieved a single-photoelectron timing resolution of better than 60 psec. The study is relevant for a new focusing DIRC RICH detector for particle identification at future Colliders such as the super B-factory or ILC, and for future TOF techniques. This study shows that a highly pixilated MCP-PMT can deliver excellent timing resolution.

  15. Time-incremental creep–fatigue damage rule for single crystal Ni-base

    NARCIS (Netherlands)

    W.A.M. Brekelmans; T. Tinga; M.G.D. Geers

    2009-01-01

    In the present paper a damage model for single crystal Ni-base superalloys is proposed that integrates time-dependent and cyclic damage into a generally applicable time-incremental damage rule. A criterion based on the Orowan stress is introduced to detect slip reversal on the microscopic level

  16. Time-incremental creep–fatigue damage rule for single crystal Ni-base superalloys

    NARCIS (Netherlands)

    Tinga, Tiedo; Brekelmans, W.A.M.; Geers, M.G.D.

    2009-01-01

    In the present paper a damage model for single crystal Ni-base superalloys is proposed that integrates time-dependent and cyclic damage into a generally applicable time-incremental damage rule. A criterion based on the Orowan stress is introduced to detect slip reversal on the microscopic level and

  17. Analysis of single-photon time resolution of FBK silicon photomultipliers

    International Nuclear Information System (INIS)

    Acerbi, Fabio; Ferri, Alessandro; Gola, Alberto; Zorzi, Nicola; Piemonte, Claudio

    2015-01-01

    We characterized and analyzed an important feature of silicon photomultipliers: the single-photon time resolution (SPTR). We characterized the SPTR of new RGB (Red–Green–Blue) type Silicon Photomultipliers and SPADs produced at FBK (Trento, Italy), studying its main limiting factors. We compared time resolution of 1×1 mm 2 and 3×3 mm 2 SiPMs and a single SiPM cell (i.e. a SPAD with integrated passive-quenching), employing a mode-locked pulsed laser with 2-ps wide pulses. We estimated the contribution of front-end electronic-noise, of cell-to-cell uniformity, and intrinsic cell time-resolution. At a single-cell level, we compared the results obtained with different layouts. With a circular cell with a top metallization covering part of the edge and enhancing the signal extraction, we reached ~20 ps FWHM of time resolution

  18. Analysis of single-photon time resolution of FBK silicon photomultipliers

    Energy Technology Data Exchange (ETDEWEB)

    Acerbi, Fabio, E-mail: acerbi@fbk.eu; Ferri, Alessandro; Gola, Alberto; Zorzi, Nicola; Piemonte, Claudio

    2015-07-01

    We characterized and analyzed an important feature of silicon photomultipliers: the single-photon time resolution (SPTR). We characterized the SPTR of new RGB (Red–Green–Blue) type Silicon Photomultipliers and SPADs produced at FBK (Trento, Italy), studying its main limiting factors. We compared time resolution of 1×1 mm{sup 2} and 3×3 mm{sup 2} SiPMs and a single SiPM cell (i.e. a SPAD with integrated passive-quenching), employing a mode-locked pulsed laser with 2-ps wide pulses. We estimated the contribution of front-end electronic-noise, of cell-to-cell uniformity, and intrinsic cell time-resolution. At a single-cell level, we compared the results obtained with different layouts. With a circular cell with a top metallization covering part of the edge and enhancing the signal extraction, we reached ~20 ps FWHM of time resolution.

  19. High-throughput gated photon counter with two detection windows programmable down to 70 ps width

    Energy Technology Data Exchange (ETDEWEB)

    Boso, Gianluca; Tosi, Alberto, E-mail: alberto.tosi@polimi.it; Zappa, Franco [Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Piazza Leonardo Da Vinci 32, 20133 Milano (Italy); Mora, Alberto Dalla [Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo Da Vinci 32, 20133 Milano (Italy)

    2014-01-15

    We present the design and characterization of a high-throughput gated photon counter able to count electrical pulses occurring within two well-defined and programmable detection windows. We extensively characterized and validated this instrument up to 100 Mcounts/s and with detection window width down to 70 ps. This instrument is suitable for many applications and proves to be a cost-effective and compact alternative to time-correlated single-photon counting equipment, thanks to its easy configurability, user-friendly interface, and fully adjustable settings via a Universal Serial Bus (USB) link to a remote computer.

  20. Optimal Estimation of Diffusion Coefficients from Noisy Time-Lapse-Recorded Single-Particle Trajectories

    DEFF Research Database (Denmark)

    Vestergaard, Christian Lyngby

    2012-01-01

    Optimal Estimation of Diusion Coecients from Noisy Time-Lapse- Measurements of Single-Particle Trajectories Single-particle tracking techniques allow quantitative measurements of diusion at the single-molecule level. Recorded time-series are mostly short and contain considerable measurement noise....... The standard method for estimating diusion coecients from single-particle trajectories is based on leastsquares tting to the experimentally measured mean square displacements. This method is highly inecient, since it ignores the high correlations inherent in these. We derive the exact maximum likelihood...... parameter values. We extend the methods to particles diusing on a uctuating substrate, e.g., exible or semi exible polymers such as DNA, and show that uctuations induce an important bias in the estimates of diusion coecients if they are not accounted for. We apply the methods to obtain precise estimates...

  1. Ultrasound-guided identification of cardiac imaging windows.

    Science.gov (United States)

    Liu, Garry; Qi, Xiu-Ling; Robert, Normand; Dick, Alexander J; Wright, Graham A

    2012-06-01

    -ray gating windows were relatively weaker: R = 0.63 (p = 0.13) and R = 0.86 (p = 0.01). For IVS gating windows, the average estimated vessel blurs during single and multiple heartbeats were 0.5 and 0.66 mm, respectively. For x-ray gating windows, the corresponding values were 0.26 and 0.44 mm, respectively. In this study, the authors showed that IVS velocity can be used to identify periods of diastasis for coronary arteries. Despite variability in mid-diastolic rest positions over multiple steady rate heartbeats, vessel blurring of 0.5-1 mm was found to be achievable using the IVS gating technique. The authors envision this leading to a new cardiac gating system that, compared with conventional ECG gating, provides better resolution and shorter scan times for coronary MRA. © 2012 American Association of Physicists in Medicine.

  2. Potential for Bias When Estimating Critical Windows for Air Pollution in Children's Health.

    Science.gov (United States)

    Wilson, Ander; Chiu, Yueh-Hsiu Mathilda; Hsu, Hsiao-Hsien Leon; Wright, Robert O; Wright, Rosalind J; Coull, Brent A

    2017-12-01

    Evidence supports an association between maternal exposure to air pollution during pregnancy and children's health outcomes. Recent interest has focused on identifying critical windows of vulnerability. An analysis based on a distributed lag model (DLM) can yield estimates of a critical window that are different from those from an analysis that regresses the outcome on each of the 3 trimester-average exposures (TAEs). Using a simulation study, we assessed bias in estimates of critical windows obtained using 3 regression approaches: 1) 3 separate models to estimate the association with each of the 3 TAEs; 2) a single model to jointly estimate the association between the outcome and all 3 TAEs; and 3) a DLM. We used weekly fine-particulate-matter exposure data for 238 births in a birth cohort in and around Boston, Massachusetts, and a simulated outcome and time-varying exposure effect. Estimates using separate models for each TAE were biased and identified incorrect windows. This bias arose from seasonal trends in particulate matter that induced correlation between TAEs. Including all TAEs in a single model reduced bias. DLM produced unbiased estimates and added flexibility to identify windows. Analysis of body mass index z score and fat mass in the same cohort highlighted inconsistent estimates from the 3 methods. © The Author(s) 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  3. Single passband microwave photonic filter using continuous-time impulse response.

    Science.gov (United States)

    Huang, Thomas X H; Yi, Xiaoke; Minasian, Robert A

    2011-03-28

    A single passband microwave photonic signal processor based on continuous time impulse response that has high resolution, multiple-taps and baseband-free response as well as exhibiting a square-top passband and tunability, is presented. The design and synthesis of the frequency response are based on a full systematic model for single passband microwave photonic filters to account for arbitrary spectrum slice shapes, which for the first time investigates the combined effects from both the dispersion-induced carrier suppression effect and the RF decay effect due to the spectrum slice width, to enable the optimum design to be realized by utilizing the carrier suppression effect to improve the filter performance. Experimental results demonstrate a high order microwave filter showing high resolution single passband filtering as well as exhibiting reconfiguration, square-top passband and tunability, for the first time to our best knowledge.

  4. Dynamically Switching among Bundled and Single Tickets with Time-Dependent Demand Rates

    Directory of Open Access Journals (Sweden)

    Serhan Duran

    2012-01-01

    Full Text Available The most important market segmentation in sports and entertainment industry is the competition between customers that buy bundled and single tickets. A common selling practice is starting the selling season with bundled ticket sales and switching to selling single tickets later on. The aim of this practice is to increase the number of customers that buy bundles, which in return increases the load factor of the events with low demand. In this paper, we investigate the effect of time dependent demand on dynamic switching times from bundled to single ticket sales and the potential revenue gain over the case where the demand rate of events is assumed to be constant with time.

  5. Can multivariable risk-benefit profiling be used to select treatment-favorable patients for thrombolysis in stroke in the 3- to 6-hour time window?

    Science.gov (United States)

    Kent, David M; Selker, Harry P; Ruthazer, Robin; Bluhmki, Erich; Hacke, Werner

    2006-12-01

    The Stroke-Thrombolytic Predictive Instrument (Stroke-TPI) uses multivariate equations to predict outcomes with and without thrombolysis. We sought to examine whether such a multivariate predictive instrument might be useful in selecting patients with a favorable risk-benefit treatment profile for therapy after 3 hours. We explored outcomes in patients from 5 major randomized clinical trials testing intravenous recombinant tissue plasminogen activator (rt-PA) classified by the Stroke-TPI as "treatment-favorable" or "treatment-unfavorable." We used iterative bootstrap re-sampling to estimate how such a model would perform on independent test data. Among patients treated within the 3- to 6-hour window, 67% of patients were classified by Stroke-TPI predicted outcomes as "treatment-favorable" and 33% were classified as "treatment-unfavorable." Outcomes in the treatment-favorable group demonstrated benefit for thrombolysis (modified Rankin Scale score < or =1: 44.0% with rt-PA versus 34.2 with placebo, P=0.005), whereas harm was demonstrated in the treatment-unfavorable group (modified Rankin Scale score < or =1: 31.3% with rt-PA versus 38.3% with placebo; P=0.004). Bootstrap resampling with complete cross-validation showed that the absolute margin of benefit in the treatment-favorable group diminished on average by 36% between derivation and independent validation sets, but still represented a significant tripling of improvement in benefit compared with conventional inclusion criteria (5.2% [interquartile range, 1.7% to 8.6%] versus 1.8% [interquartile range, -0.5 to 4.1], P<0.0001). Such multivariable risk-benefit profiling may be useful in the selection of acute stroke patients for rt-PA therapy even more than 3 hours after symptom onset. Prospective testing is indicated.

  6. Improving the counting efficiency in time-correlated single photon counting experiments by dead-time optimization

    Energy Technology Data Exchange (ETDEWEB)

    Peronio, P.; Acconcia, G.; Rech, I.; Ghioni, M. [Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano (Italy)

    2015-11-15

    Time-Correlated Single Photon Counting (TCSPC) has been long recognized as the most sensitive method for fluorescence lifetime measurements, but often requiring “long” data acquisition times. This drawback is related to the limited counting capability of the TCSPC technique, due to pile-up and counting loss effects. In recent years, multi-module TCSPC systems have been introduced to overcome this issue. Splitting the light into several detectors connected to independent TCSPC modules proportionally increases the counting capability. Of course, multi-module operation also increases the system cost and can cause space and power supply problems. In this paper, we propose an alternative approach based on a new detector and processing electronics designed to reduce the overall system dead time, thus enabling efficient photon collection at high excitation rate. We present a fast active quenching circuit for single-photon avalanche diodes which features a minimum dead time of 12.4 ns. We also introduce a new Time-to-Amplitude Converter (TAC) able to attain extra-short dead time thanks to the combination of a scalable array of monolithically integrated TACs and a sequential router. The fast TAC (F-TAC) makes it possible to operate the system towards the upper limit of detector count rate capability (∼80 Mcps) with reduced pile-up losses, addressing one of the historic criticisms of TCSPC. Preliminary measurements on the F-TAC are presented and discussed.

  7. Improving the counting efficiency in time-correlated single photon counting experiments by dead-time optimization

    Science.gov (United States)

    Peronio, P.; Acconcia, G.; Rech, I.; Ghioni, M.

    2015-11-01

    Time-Correlated Single Photon Counting (TCSPC) has been long recognized as the most sensitive method for fluorescence lifetime measurements, but often requiring "long" data acquisition times. This drawback is related to the limited counting capability of the TCSPC technique, due to pile-up and counting loss effects. In recent years, multi-module TCSPC systems have been introduced to overcome this issue. Splitting the light into several detectors connected to independent TCSPC modules proportionally increases the counting capability. Of course, multi-module operation also increases the system cost and can cause space and power supply problems. In this paper, we propose an alternative approach based on a new detector and processing electronics designed to reduce the overall system dead time, thus enabling efficient photon collection at high excitation rate. We present a fast active quenching circuit for single-photon avalanche diodes which features a minimum dead time of 12.4 ns. We also introduce a new Time-to-Amplitude Converter (TAC) able to attain extra-short dead time thanks to the combination of a scalable array of monolithically integrated TACs and a sequential router. The fast TAC (F-TAC) makes it possible to operate the system towards the upper limit of detector count rate capability (˜80 Mcps) with reduced pile-up losses, addressing one of the historic criticisms of TCSPC. Preliminary measurements on the F-TAC are presented and discussed.

  8. Daylight Redirecting Window Films

    Science.gov (United States)

    2013-09-01

    The open office area (Figure 9) is 48’ deep with a sloped ceiling designed to disperse light down into the cubicle workstations. The sloped ceiling...Ceiling Ht. 9’ , 10’* Window VT 40%, 70%* Office Furniture 60” Cubicle * Lighting Schedule ASHRAE 90.1* Blinds Control Always Closed, Automated...2829 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) ESTCP Program Office Dr. James

  9. Windows with improved energy performances

    DEFF Research Database (Denmark)

    Laustsen, Jacob Birck; Svendsen, Svend

    2003-01-01

    Heat loss through windows represents a considerable part of the total heat loss from houses. However, apart from providing daylight access and view, windows offer a unique potential for solar gain to be exploited during the heating season. Until now valuation of the energy performance of windows...... has primary focused on the heat loss coefficient, U-value. However, as the U-value, especially for the glazing part, has improved considerably during the last years, the total solar energy transmittance, g-value, has become equally important to the total energy performance of windows. Improved energy...... performance of windows can be reached by development of each element of the window, but to gain a considerable improvement in the overall energy performance all elements of the windows need to be examined together and the construction optimised. This paper describes potential improvements of window elements...

  10. Time delay between singly and doubly ionizing wavepackets in laser-driven helium

    International Nuclear Information System (INIS)

    Parker, J S; Doherty, B J S; Meharg, K J; Taylor, K T

    2003-01-01

    We present calculations of the time delay between single and double ionization of helium, obtained from full-dimensionality numerical integrations of the helium-laser Schroedinger equation. The notion of a quantum mechanical time delay is defined in terms of the interval between correlated bursts of single and double ionization. Calculations are performed at 390 and 780 nm in laser intensities that range from 2 x 10 14 to 14 x 10 14 Wcm -2 . We find results consistent with the rescattering model of double ionization but supporting its classical interpretation only at 780 nm. (letter to the editor)

  11. Design of the beryllium window for Brookhaven Linac Isotope Producer

    Energy Technology Data Exchange (ETDEWEB)

    Nayak, S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Mapes, M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Raparia, D. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-11-01

    In the Brookhaven Linac Isotope Producer (BLIP) beam line, there were two Beryllium (Be) windows with an air gap to separate the high vacuum upstream side from low vacuum downstream side. There had been frequent window failures in the past which affected the machine productivity and increased the radiation dose received by workers due to unplanned maintenance. To improve the window life, design of Be window is reexamined. Detailed structural and thermal simulations are carried out on Be window for different design parameters and loading conditions to come up with better design to improve the window life. The new design removed the air gap and connect the both beam lines with a Be window in-between. The new design has multiple advantages such as 1) reduces the beam energy loss (because of one window with no air gap), 2) reduces air activation due to nuclear radiation and 3) increased the machine reliability as there is no direct pressure load during operation. For quick replacement of this window, an aluminum bellow coupled with load binder was designed. There hasn’t been a single window failure since the new design was implemented in 2012.

  12. Design of the beryllium window for Brookhaven Linac Isotope Producer

    International Nuclear Information System (INIS)

    Nayak, S.; Mapes, M.; Raparia, D.

    2015-01-01

    In the Brookhaven Linac Isotope Producer (BLIP) beam line, there were two Beryllium (Be) windows with an air gap to separate the high vacuum upstream side from low vacuum downstream side. There had been frequent window failures in the past which affected the machine productivity and increased the radiation dose received by workers due to unplanned maintenance. To improve the window life, design of Be window is reexamined. Detailed structural and thermal simulations are carried out on Be window for different design parameters and loading conditions to come up with better design to improve the window life. The new design removed the air gap and connect the both beam lines with a Be window in-between. The new design has multiple advantages such as 1) reduces the beam energy loss (because of one window with no air gap), 2) reduces air activation due to nuclear radiation and 3) increased the machine reliability as there is no direct pressure load during operation. For quick replacement of this window, an aluminum bellow coupled with load binder was designed. There hasn't been a single window failure since the new design was implemented in 2012.

  13. USB Storage Device Forensics for Windows 10.

    Science.gov (United States)

    Arshad, Ayesha; Iqbal, Waseem; Abbas, Haider

    2017-07-18

    Significantly increased use of USB devices due to their user-friendliness and large storage capacities poses various threats for many users/companies in terms of data theft that becomes easier due to their efficient mobility. Investigations for such data theft activities would require gathering critical digital information capable of recovering digital forensics artifacts like date, time, and device information. This research gathers three sets of registry and logs data: first, before insertion; second, during insertion; and the third, after removal of a USB device. These sets are analyzed to gather evidentiary information from Registry and Windows Event log that helps in tracking a USB device. This research furthers the prior research on earlier versions of Microsoft Windows and compares it with latest Windows 10 system. Comparison of Windows 8 and Windows 10 does not show much difference except for new subkey under USB Key in registry. However, comparison of Windows 7 with latest version indicates significant variances. © 2017 American Academy of Forensic Sciences.

  14. Rugged sensor window materials for harsh environments

    Science.gov (United States)

    Bayya, Shyam; Villalobos, Guillermo; Kim, Woohong; Sanghera, Jasbinger; Hunt, Michael; Aggarwal, Ishwar D.

    2014-09-01

    There are several military or commercial systems operating in very harsh environments that require rugged windows. On some of these systems, windows become the single point of failure. These applications include sensor or imaging systems, high-energy laser weapons systems, submarine photonic masts, IR countermeasures and missiles. Based on the sea or land or air based platforms the window or dome on these systems must withstand wave slap, underwater or ground based explosions, or survive flight through heavy rain and sand storms while maintaining good optical transmission in the desired wavelength range. Some of these applications still use softer ZnS or fused silica windows because of lack of availability of rugged materials in shapes or sizes required. Sapphire, ALON and spinel are very rugged materials with significantly higher strengths compared to ZnS and fused silica. There have been recent developments in spinel, ALON and sapphire materials to fabricate in large sizes and conformal shapes. We have been developing spinel ceramics for several of these applications. We are also developing β-SiC as a transparent window material as it has higher hardness, strength, and toughness than sapphire, ALON and spinel. This paper gives a summary of our recent findings.

  15. A tabu search algorithm for scheduling a single robot in a job-shop environment

    OpenAIRE

    Hurink, Johann; Knust, Sigrid

    2002-01-01

    We consider a single-machine scheduling problem which arises as a subproblem in a job-shop environment where the jobs have to be transported between the machines by a single transport robot. The robot scheduling problem may be regarded as a generalization of the travelling-salesman problem with time windows, where additionally generalized precedence constraints have to be respected. The objective is to determine a sequence of all nodes and corresponding starting times in the given time window...

  16. Digital atom interferometer with single particle control on a discretized space-time geometry.

    Science.gov (United States)

    Steffen, Andreas; Alberti, Andrea; Alt, Wolfgang; Belmechri, Noomen; Hild, Sebastian; Karski, Michał; Widera, Artur; Meschede, Dieter

    2012-06-19

    Engineering quantum particle systems, such as quantum simulators and quantum cellular automata, relies on full coherent control of quantum paths at the single particle level. Here we present an atom interferometer operating with single trapped atoms, where single particle wave packets are controlled through spin-dependent potentials. The interferometer is constructed from a sequence of discrete operations based on a set of elementary building blocks, which permit composing arbitrary interferometer geometries in a digital manner. We use this modularity to devise a space-time analogue of the well-known spin echo technique, yielding insight into decoherence mechanisms. We also demonstrate mesoscopic delocalization of single atoms with a separation-to-localization ratio exceeding 500; this result suggests their utilization beyond quantum logic applications as nano-resolution quantum probes in precision measurements, being able to measure potential gradients with precision 5 x 10(-4) in units of gravitational acceleration g.

  17. Understanding and Supporting Window Switching

    NARCIS (Netherlands)

    Tak, S.

    2011-01-01

    Switching between windows on a computer is a frequent activity, but finding and switching to the target window can be inefficient. This thesis aims to better un-derstand and support window switching. It explores two issues: (1) the lack of knowledge of how people currently interact with and switch

  18. Pulsed single-photon spectrometer by frequency-to-time mapping using chirped fiber Bragg gratings.

    Science.gov (United States)

    Davis, Alex O C; Saulnier, Paul M; Karpiński, Michał; Smith, Brian J

    2017-05-29

    A fiber-integrated spectrometer for single-photon pulses outside the telecommunications wavelength range based upon frequency-to-time mapping, implemented by chromatic group delay dispersion (GDD), and precise temporally-resolved single-photon counting, is presented. A chirped fiber Bragg grating provides low-loss GDD, mapping the frequency distribution of an input pulse onto the temporal envelope of the output pulse. Time-resolved detection with fast single-photon-counting modules enables monitoring of a wavelength range from 825 nm to 835 nm with nearly uniform efficiency at 55 pm resolution (24 GHz at 830 nm). To demonstrate the versatility of this technique, spectral interference of heralded single photons and the joint spectral intensity distribution of a photon-pair source are measured. This approach to single-photon-level spectral measurements provides a route to realize applications of time-frequency quantum optics at visible and near-infrared wavelengths, where multiple spectral channels must be simultaneously monitored.

  19. Single-molecule three-color FRET with both negligible spectral overlap and long observation time.

    Directory of Open Access Journals (Sweden)

    Sanghwa Lee

    Full Text Available Full understanding of complex biological interactions frequently requires multi-color detection capability in doing single-molecule fluorescence resonance energy transfer (FRET experiments. Existing single-molecule three-color FRET techniques, however, suffer from severe photobleaching of Alexa 488, or its alternative dyes, and have been limitedly used for kinetics studies. In this work, we developed a single-molecule three-color FRET technique based on the Cy3-Cy5-Cy7 dye trio, thus providing enhanced observation time and improved data quality. Because the absorption spectra of three fluorophores are well separated, real-time monitoring of three FRET efficiencies was possible by incorporating the alternating laser excitation (ALEX technique both in confocal microscopy and in total-internal-reflection fluorescence (TIRF microscopy.

  20. Design considerations for foil windows for PET radioisotope targets

    International Nuclear Information System (INIS)

    Hughey, B.J.; Shefer, R.E.; Klinkowstein, R.E.; Welch, M.J.

    1992-01-01

    This paper describes the results of a study performed at SRL to develop analytical and computational techniques for optimizing the design of conduction-cooled foil windows for PET targets. Single foil conduction cooled windows have been found to be good target entrance windows for both low energy accelerators and medium energy cyclotrons. Detailed thermal analysis has given an approximate analytical expression for the maximum temperature reached in a foil window under conditions of realistic ion beam bombardment. The effects of 'hot spots' in the beam density profile were investigated. It was shown that a factor of two safety margin in window design should be adequate to compensate for any possible beam hot spots. In addition, the reduction of foil stress by slack mounting was verified by experiments. The properties of conventional and novel foil materials were investigated for use in conduction cooled windows. Novel foil materials include two-component Al/Ti and Al/Havar foil. Results on the testing of candidate foil materials for thermal conductivity and mechanical strength at elevated temperature were presented. Two optimum foil window geometries were analyzed: a high aspect ratio window and a multiply slotted window. The multiply slotted window combines the advantages of a high aspect ratio foil window with a circular beam strike and is a promising window design for both TCA and cyclotron targets. A multiply slotted window for a N 2 gas target for 15 O production was designed using the methodologies discussed above. This prototype target was successfully tested using the TCA beam at SRL. (author) 6 figs., 3 tabs., 10 refs

  1. Anti-control of chaos of single time-scale brushless DC motor.

    Science.gov (United States)

    Ge, Zheng-Ming; Chang, Ching-Ming; Chen, Yen-Sheng

    2006-09-15

    Anti-control of chaos of single time-scale brushless DC motors is studied in this paper. In order to analyse a variety of periodic and chaotic phenomena, we employ several numerical techniques such as phase portraits, bifurcation diagrams and Lyapunov exponents. Anti-control of chaos can be achieved by adding an external constant term or an external periodic term.

  2. Testing the Efficacy of a Scholarship Program for Single Parent, Post-Freshmen, Full Time Undergraduates

    Science.gov (United States)

    Carpenter, Dick M., II; Kaka, Sarah J.; Tygret, Jennifer A.; Cathcart, Katy

    2018-01-01

    This study examines the efficacy of a scholarship program designed to assist single parent, post-freshmen, full time undergraduate students and predictors of success among a sample of said students, where success is defined as progress toward completion, academic achievement, and degree completion. Results of fixed effects regression and…

  3. Insensitivity of single particle time domain measurements to laser velocimeter 'Doppler ambiguity.'

    Science.gov (United States)

    Johnson, D. A.

    1973-01-01

    It is shown that single particle time domain measurements in high speed gas flows obtained by a laser velocimeter technique developed for use in wind tunnels are not affected by the so-called 'Doppler ambiguity.' A comparison of hot-wire anemometer and laser velocimeter measurements taken under similar flow conditions is used for the demonstration.

  4. Analysis of Kinetic Intermediates in Single-Particle Dwell-Time Distributions

    NARCIS (Netherlands)

    Floyd, Daniel L.; Harrison, Stephen C.; Oijen, Antoine M. van

    2010-01-01

    Many biological and chemical processes proceed through one or more intermediate steps. Statistical analysis of dwell-time distributions from single molecule trajectories enables the study of intermediate steps that are not directly observable. Here, we discuss the application of the randomness

  5. Single-machine scheduling with release dates, due dates, and family setup times

    NARCIS (Netherlands)

    J.M.J. Schutten (Marco); S.L. van de Velde (Steef); W.H.M. Zijm

    1996-01-01

    textabstractWe address the NP-hard problem of scheduling n independent jobs with release dates, due dates, and family setup times on a single machine to minimize the maximum lateness. This problem arises from the constant tug-of-war going on in manufacturing between efficient production and delivery

  6. Cleaning of the first mirrors and diagnostic windows by YAG laser on HL-2A

    International Nuclear Information System (INIS)

    Zhou, Y; Zheng, L; Li, Y G; Li, L C; Jiao, Y M; Gao, H; Zhao, G

    2009-01-01

    A laser cleaning system for HL-2A tokamak first mirrors and diagnostic windows has been developed recently. A detailed description of the laser cleaning procedure is presented. The optical transmission performance measured before and after the laser cleaning of the impurity film deposited on the optical elements is investigated. HL-2A deposited layers on metal mirrors and glass windows with thicknesses of about 1 and 4 μm, respectively, are clearly removed by irradiation with a single pulse of a Q-switched Nd:YAG laser with energy density of 0.4 and 2.8 J cm -2 , respectively. The feasibility of cleaning ECE windows is demonstrated. A cleaning time of about 5 min is suitable for application in fusion devices. The comparison of results obtained at different laser wavelengths shows that there is a greater probability of damage to the metallic mirror surface with a short laser wavelength than with longer wavelength.

  7. Monitoring of Optimal Cerebral Perfusion Pressure in Traumatic Brain Injured Patients Using a Multi-Window Weighting Algorithm.

    Science.gov (United States)

    Liu, Xiuyun; Maurits, Natasha M; Aries, Marcel J H; Czosnyka, Marek; Ercole, Ari; Donnelly, Joseph; Cardim, Danilo; Kim, Dong-Joo; Dias, Celeste; Cabeleira, Manuel; Smielewski, Peter

    2017-11-15

    Methods to identify an autoregulation guided "optimal" cerebral perfusion pressure (CPPopt) for traumatic brain injury patients (TBI) have been reported through several studies. An important drawback of existing methodology is that CPPopt can be calculated only in ∼50-60% of the monitoring time. In this study, we hypothesized that the CPPopt yield and the continuity can be improved significantly through application of a multi-window and weighting calculation algorithm, without adversely affecting preservation of its prognostic value. Data of 526 severe TBI patients admitted between 2003 and 2015 were studied. The multi-window CPPopt calculation was based on automated curve fitting in pressure reactivity index (PRx)-CPP plots using data from 36 increasing length time windows (2-8 h). The resulting matrix of CPPopts was then averaged in a weighted manner. The yield, continuity, and stability of CPPopt were studied. The difference between patients' actual CPP and CPPopt (ΔCPP) was calculated and the association with outcome was analyzed. Overall, the multi-window method demonstrated more continuous and stable presentation of CPPopt in this cohort. The new method resulted in a mean (±SE) CPPopt yield of 94% ± 2.1%, as opposed to the previous single-window-based CPPopt yield of 51% ± 0.94%. The stability of CPPopt across the whole monitoring period was significantly improved by using the new algorithm (p window algorithm and outcome was similar to that for CPPopt calculated on the basis of a single window. In conclusion, this study validates the use of a new multi-window and weighting algorithm for significant improvement of CPPopt yield in TBI patients. This methodological improvement is essential for its clinical application in future CPPopt trials.

  8. Single view reflectance capture using multiplexed scattering and time-of-flight imaging

    OpenAIRE

    Zhao, Shuang; Velten, Andreas; Raskar, Ramesh; Bala, Kavita; Naik, Nikhil Deepak

    2011-01-01

    This paper introduces the concept of time-of-flight reflectance estimation, and demonstrates a new technique that allows a camera to rapidly acquire reflectance properties of objects from a single view-point, over relatively long distances and without encircling equipment. We measure material properties by indirectly illuminating an object by a laser source, and observing its reflected light indirectly using a time-of-flight camera. The configuration collectively acquires dense angular, but l...

  9. Single-Server Queueing System with Markov-Modulated Arrivals and Service Times

    OpenAIRE

    Dimitrov, Mitko

    2011-01-01

    Key words: Markov-modulated queues, waiting time, heavy traffic. Markov-modulated queueing systems are those in which the input process or service mechanism is influenced by an underlying Markov chain. Several models for such systems have been investigated. In this paper we present heavy traffic analysis of single queueing system with Poisson arrival process whose arrival rate is a function of the state of Markov chain and service times depend on the state of the same Markov chain at the e...

  10. Pseudospectral operational matrix for numerical solution of single and multiterm time fractional diffusion equation

    OpenAIRE

    GHOLAMI, SAEID; BABOLIAN, ESMAIL; JAVIDI, MOHAMMAD

    2016-01-01

    This paper presents a new numerical approach to solve single and multiterm time fractional diffusion equations. In this work, the space dimension is discretized to the Gauss$-$Lobatto points. We use the normalized Grunwald approximation for the time dimension and a pseudospectral successive integration matrix for the space dimension. This approach shows that with fewer numbers of points, we can approximate the solution with more accuracy. Some examples with numerical results in tables and fig...

  11. Multiple linear regression to estimate time-frequency electrophysiological responses in single trials.

    Science.gov (United States)

    Hu, L; Zhang, Z G; Mouraux, A; Iannetti, G D

    2015-05-01

    Transient sensory, motor or cognitive event elicit not only phase-locked event-related potentials (ERPs) in the ongoing electroencephalogram (EEG), but also induce non-phase-locked modulations of ongoing EEG oscillations. These modulations can be detected when single-trial waveforms are analysed in the time-frequency domain, and consist in stimulus-induced decreases (event-related desynchronization, ERD) or increases (event-related synchronization, ERS) of synchrony in the activity of the underlying neuronal populations. ERD and ERS reflect changes in the parameters that control oscillations in neuronal networks and, depending on the frequency at which they occur, represent neuronal mechanisms involved in cortical activation, inhibition and binding. ERD and ERS are commonly estimated by averaging the time-frequency decomposition of single trials. However, their trial-to-trial variability that can reflect physiologically-important information is lost by across-trial averaging. Here, we aim to (1) develop novel approaches to explore single-trial parameters (including latency, frequency and magnitude) of ERP/ERD/ERS; (2) disclose the relationship between estimated single-trial parameters and other experimental factors (e.g., perceived intensity). We found that (1) stimulus-elicited ERP/ERD/ERS can be correctly separated using principal component analysis (PCA) decomposition with Varimax rotation on the single-trial time-frequency distributions; (2) time-frequency multiple linear regression with dispersion term (TF-MLRd) enhances the signal-to-noise ratio of ERP/ERD/ERS in single trials, and provides an unbiased estimation of their latency, frequency, and magnitude at single-trial level; (3) these estimates can be meaningfully correlated with each other and with other experimental factors at single-trial level (e.g., perceived stimulus intensity and ERP magnitude). The methods described in this article allow exploring fully non-phase-locked stimulus-induced cortical

  12. Windows Home Server users guide

    CERN Document Server

    Edney, Andrew

    2008-01-01

    Windows Home Server brings the idea of centralized storage, backup and computer management out of the enterprise and into the home. Windows Home Server is built for people with multiple computers at home and helps to synchronize them, keep them updated, stream media between them, and back them up centrally. Built on a similar foundation as the Microsoft server operating products, it's essentially Small Business Server for the home.This book details how to install, configure, and use Windows Home Server and explains how to connect to and manage different clients such as Windows XP, Windows Vist

  13. Teach yourself visually Windows 10

    CERN Document Server

    McFedries, Paul

    2015-01-01

    Learn Windows 10 visually with step-by-step instructions Teach Yourself VISUALLY Windows 10 is the visual learner's guide to the latest Windows upgrade. Completely updated to cover all the latest features, this book walks you step-by-step through over 150 essential Windows tasks. Using full color screen shots and clear instruction, you'll learn your way around the interface, set up user accounts, play media files, download photos from your camera, go online, set up email, and much more. You'll even learn how to customize Windows 10 to suit the way you work best, troubleshoot and repair common

  14. Detecting shifts in gene regulatory networks during time-course experiments at single-time-point temporal resolution.

    Science.gov (United States)

    Takenaka, Yoichi; Seno, Shigeto; Matsuda, Hideo

    2015-10-01

    Comprehensively understanding the dynamics of biological systems is one of the greatest challenges in biology. Vastly improved biological technologies have provided vast amounts of information that must be understood by bioinformatics and systems biology researchers. Gene regulations have been frequently modeled by ordinary differential equations or graphical models based on time-course gene expression profiles. The state-of-the-art computational approaches for analyzing gene regulations assume that their models are same throughout time-course experiments. However, these approaches cannot easily analyze transient changes at a time point, such as diauxic shift. We propose a score that analyzes the gene regulations at each time point. The score is based on the information gains of information criterion values. The method detects the shifts in gene regulatory networks (GRNs) during time-course experiments with single-time-point resolution. The effectiveness of the method is evaluated on the diauxic shift from glucose to lactose in Escherichia coli. Gene regulation shifts were detected at two time points: the first corresponding to the time at which the growth of E. coli ceased and the second corresponding to the end of the experiment, when the nutrient sources (glucose and lactose) had become exhausted. According to these results, the proposed score and method can appropriately detect the time of gene regulation shifts. The method based on the proposed score provides a new tool for analyzing dynamic biological systems. Because the score value indicates the strength of gene regulation at each time point in a gene expression profile, it can potentially infer hidden GRNs from time-course experiments.

  15. Windows Azure web sites

    CERN Document Server

    Chambers, James

    2013-01-01

    A no-nonsense guide to maintaining websites in Windows Azure If you're looking for a straightforward, practical guide to get Azure websites up and running, then this is the book for you. This to-the-point guide provides you with the tools you need to move and maintain a website in the cloud. You'll discover the features that most affect developers and learn how they can be leveraged to work to your advantage. Accompanying projects enhance your learning experience and help you to walk away with a thorough understanding of Azure's supported technologies, site deployment, and manageme

  16. Transparent aerogel Windows

    DEFF Research Database (Denmark)

    Jensen, Karsten Ingerslev; Schultz, Jørgen Munthe

    In a recent EU FP5 project, monolithic silica aerogel was further developed with respect to the production process at pilot-scale, its properties and the application as transparent insulation material in highly insulating and transparent windows. The aerogel production process has been optimised......-value of 0.7 W/m²K for about 14 mm aerogel thickness, which for a 20 mm thickness corresponds to a U-value of approximately 0.5 W/m²K. No other known glazing exhibits such an excellent combination of solar transmittance and heat loss coefficient. At a Danish location and North facing, the energy balance...

  17. Windows on animal minds.

    Science.gov (United States)

    Griffin, D R

    1995-06-01

    The simple kinds of conscious thinking that probably occur in nonhuman animals can be studied objectively by utilizing the same basic procedure that we use every day to infer what our human companions think and feel. This is to base such inferences on communicative behavior, broadly defined to include human language, nonverbal communication, and semantic communication in apes, dolphins, parrots, and honeybees. It seems likely that animals often experience something similar to the messages they communicate. Although this figurative window on other minds is obviously imperfect, it is already contributing significantly to our growing understanding and appreciation of animal mentality.

  18. Invariant sets for Windows

    CERN Document Server

    Morozov, Albert D; Dragunov, Timothy N; Malysheva, Olga V

    1999-01-01

    This book deals with the visualization and exploration of invariant sets (fractals, strange attractors, resonance structures, patterns etc.) for various kinds of nonlinear dynamical systems. The authors have created a special Windows 95 application called WInSet, which allows one to visualize the invariant sets. A WInSet installation disk is enclosed with the book.The book consists of two parts. Part I contains a description of WInSet and a list of the built-in invariant sets which can be plotted using the program. This part is intended for a wide audience with interests ranging from dynamical

  19. Windows Azure Platform

    CERN Document Server

    Redkar, Tejaswi

    2011-01-01

    The Windows Azure Platform has rapidly established itself as one of the most sophisticated cloud computing platforms available. With Microsoft working to continually update their product and keep it at the cutting edge, the future looks bright - if you have the skills to harness it. In particular, new features such as remote desktop access, dynamic content caching and secure content delivery using SSL make the latest version of Azure a more powerful solution than ever before. It's widely agreed that cloud computing has produced a paradigm shift in traditional architectural concepts by providin

  20. Windows XP ends its life at CERN – register for Windows 7 training!

    CERN Multimedia

    Michał Kwiatek (IT-OIS)

    2012-01-01

    Windows XP has been around for over 10 years and it is now time to move on. At CERN, general support for Windows XP will end in December 2012, and before this date users are requested to schedule a migration to the next version of WindowsWindows 7.   Windows 7 is already well established at CERN – it is used by a large majority of users. In fact, there was a considerable user demand even before its official release in October 2009 and its adoption has been smooth. Users praise Windows 7 for its improved stability and a clear advantage on laptops is a much more efficient implementation of offline files. The migration to Windows 7 involves a reinstallation of the operating system. Files stored in user home folders on DFS will be immediately available after the reinstallation. Applications will be upgraded to more recent versions and in certain cases, an application may even be replaced by another application providing the same functionality. Microsoft Office suite is a good ...

  1. Real-time Bacterial Detection by Single Cell Based Sensors UsingSynchrotron FTIR Spectromicroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Veiseh, Mandana; Veiseh, Omid; Martin, Michael C.; Bertozzi,Carolyn; Zhang, Miqin

    2005-08-10

    Microarrays of single macrophage cell based sensors weredeveloped and demonstrated for real time bacterium detection bysynchrotron FTIR microscopy. The cells were patterned on gold-SiO2substrates via a surface engineering technique by which the goldelectrodes were immobilized with fibronectin to mediate cell adhesion andthe silicon oxide background were passivated with PEG to resist proteinadsorption and cell adhesion. Cellular morphology and IR spectra ofsingle, double, and triple cells on gold electrodes exposed tolipopolysaccharide (LPS) of different concentrations were compared toreveal the detection capabilities of these biosensors. The single-cellbased sensors were found to generate the most significant IR wave numbervariation and thus provide the highest detection sensitivity. Changes inmorphology and IR spectrum for single cells exposed to LPS were found tobe time- and concentration-dependent and correlated with each other verywell. FTIR spectra from single cell arrays of gold electrodes withsurface area of 25 mu-m2, 100 mu-m2, and 400 mu-m2 were acquired usingboth synchrotron and conventional FTIR spectromicroscopes to study thesensitivity of detection. The results indicated that the developedsingle-cell platform can be used with conventional FTIRspectromicroscopy. This technique provides real-time, label-free, andrapid bacterial detection, and may allow for statistic and highthroughput analyses, and portability.

  2. Time-domain single-source integral equations for analyzing scattering from homogeneous penetrable objects

    KAUST Repository

    Valdés, Felipe

    2013-03-01

    Single-source time-domain electric-and magnetic-field integral equations for analyzing scattering from homogeneous penetrable objects are presented. Their temporal discretization is effected by using shifted piecewise polynomial temporal basis functions and a collocation testing procedure, thus allowing for a marching-on-in-time (MOT) solution scheme. Unlike dual-source formulations, single-source equations involve space-time domain operator products, for which spatial discretization techniques developed for standalone operators do not apply. Here, the spatial discretization of the single-source time-domain integral equations is achieved by using the high-order divergence-conforming basis functions developed by Graglia alongside the high-order divergence-and quasi curl-conforming (DQCC) basis functions of Valdés The combination of these two sets allows for a well-conditioned mapping from div-to curl-conforming function spaces that fully respects the space-mapping properties of the space-time operators involved. Numerical results corroborate the fact that the proposed procedure guarantees accuracy and stability of the MOT scheme. © 2012 IEEE.

  3. Invariant operator theory for the single-photon energy in time-varying media

    International Nuclear Information System (INIS)

    Jeong-Ryeol, Choi

    2010-01-01

    After the birth of quantum mechanics, the notion in physics that the frequency of light is the only factor that determines the energy of a single photon has played a fundamental role. However, under the assumption that the theory of Lewis–Riesenfeld invariants is applicable in quantum optics, it is shown in the present work that this widely accepted notion is valid only for light described by a time-independent Hamiltonian, i.e., for light in media satisfying the conditions, ε(i) = ε(0), μ(t) = μ(0), and σ(t) = 0 simultaneously. The use of the Lewis–Riesenfeld invariant operator method in quantum optics leads to a marvelous result: the energy of a single photon propagating through time-varying linear media exhibits nontrivial time dependence without a change of frequency. (general)

  4. A natural-color mapping for single-band night-time image based on FPGA

    Science.gov (United States)

    Wang, Yilun; Qian, Yunsheng

    2018-01-01

    A natural-color mapping for single-band night-time image method based on FPGA can transmit the color of the reference image to single-band night-time image, which is consistent with human visual habits and can help observers identify the target. This paper introduces the processing of the natural-color mapping algorithm based on FPGA. Firstly, the image can be transformed based on histogram equalization, and the intensity features and standard deviation features of reference image are stored in SRAM. Then, the real-time digital images' intensity features and standard deviation features are calculated by FPGA. At last, FPGA completes the color mapping through matching pixels between images using the features in luminance channel.

  5. Reentrant behaviors in the phase diagram of spin-1 planar ferromagnets with easy-axis single-ion anisotropy via the Devlin two-time Green function framework

    Science.gov (United States)

    Mercaldo, M. T.; Rabuffo, I.; De Cesare, L.; Caramico D'Auria, A.

    2017-10-01

    The Devlin two-time Green function framework is used to investigate the role played by the easy-axis single-ion anisotropy on the phase diagram of (d > 2) -dimensional spin-1 planar ferromagnets which exhibit a magnetic-field-induced quantum phase transition (QPT). In this scheme, the exchange anisotropy terms in the equations of motion are treated at the Tyablikov decoupling level while the crystal field anisotropy contribution is handled exactly. The emerging key result is a reentrant structure of the phase diagram close to the quantum critical point for a well defined window of values of the single-ion anisotropy parameter. This experimentally interesting feature was recently recovered by employing the Anderson-Callen decoupling (ACD) which is considered to provide meaningful results only for small values of the single-ion anisotropy parameter. In this context, our findings suggest that the simplest ACD treatment offers the possibility to have, at least qualitatively, a correct physical scenario of quantum criticality close to a field-induced QPT avoiding the limiting mathematical difficulties involved in the Devlin scheme.

  6. Using machine learning to identify structural breaks in single-group interrupted time series designs.

    Science.gov (United States)

    Linden, Ariel; Yarnold, Paul R

    2016-12-01

    Single-group interrupted time series analysis (ITSA) is a popular evaluation methodology in which a single unit of observation is being studied, the outcome variable is serially ordered as a time series and the intervention is expected to 'interrupt' the level and/or trend of the time series, subsequent to its introduction. Given that the internal validity of the design rests on the premise that the interruption in the time series is associated with the introduction of the treatment, treatment effects may seem less plausible if a parallel trend already exists in the time series prior to the actual intervention. Thus, sensitivity analyses should focus on detecting structural breaks in the time series before the intervention. In this paper, we introduce a machine-learning algorithm called optimal discriminant analysis (ODA) as an approach to determine if structural breaks can be identified in years prior to the initiation of the intervention, using data from California's 1988 voter-initiated Proposition 99 to reduce smoking rates. The ODA analysis indicates that numerous structural breaks occurred prior to the actual initiation of Proposition 99 in 1989, including perfect structural breaks in 1983 and 1985, thereby casting doubt on the validity of treatment effects estimated for the actual intervention when using a single-group ITSA design. Given the widespread use of ITSA for evaluating observational data and the increasing use of machine-learning techniques in traditional research, we recommend that structural break sensitivity analysis is routinely incorporated in all research using the single-group ITSA design. © 2016 John Wiley & Sons, Ltd.

  7. Windows on the axion

    International Nuclear Information System (INIS)

    Turner, M.S.

    1989-04-01

    Peccei-Quinn symmetry with attendant axion is a most compelling, and perhaps the most minimal, extension of the standard model, as it provides a very elegant solution to the nagging strong CP-problem associated with the Θ vacuum structure of QCD. However, particle physics gives little guidance as to the axion mass; a priori, the plausible values span the range: 10/sup /minus/12/ eV /approx lt/ m/sub a/ /approx lt/ 10 6 eV, some 18 orders-of-magnitude. Axions have a host of interesting astrophysical and cosmological effects, including, modifying the evolution of stars of all types (our sun, red giants, white dwarfs, and neutron stars), contributing significantly to the mass density of the Universe today, and producing detectable line radiation through the decays of relic axions. Consideration of these effects has probed 14 orders-of-magnitude in axion mass, and has left open only two windows for further exploration: 10/sup /minus/6/ eV /approx lt/ m/sub a/ /approx lt/ 10/sup /minus/3/ eV and 1 eV /approx lt/ m/sub a/ /approx lt/ 5 eV (hadronic axions only). Both these windows are accessible to experiment, and a variety of very interesting experiments, all of which involve ''heavenly axions,'' are being planned or are underway. 58 refs., 6 figs., 1 tab

  8. WINDOW-CLEANING

    CERN Multimedia

    Environmental Section / ST-TFM

    2001-01-01

    The two-month window-cleaning session on the Meyrin, Prévessin and LEP sites will soon begin. The cleaning contractors will work from Monday to Saturday, every week from 4.00 a.m. to 8.00 p.m. The work will be organised so as to disturb users as little as possible. In any event, a work notice will be left in each office 24 hours beforehand. To prevent any damage to documents or items which could occur despite the precautions taken, please clear completely the window-sills and the area immediately around them. If, however, for valid reasons, the work cannot be done on the scheduled day, please inform the Environmental Section by telephoning: 73753 / 74233 / 72242 If you are going to be absent during this two-month period, we should be grateful if you would clear the above mentioned areas before your departure. REMINDER To allow more thorough cleaning of the entrance doors to buildings and also facilitate the weekly work of the cleaning contractors, we ask you to make use of the notice boards at the...

  9. Windows on the axion

    Energy Technology Data Exchange (ETDEWEB)

    Turner, M.S.

    1989-04-01

    Peccei-Quinn symmetry with attendant axion is a most compelling, and perhaps the most minimal, extension of the standard model, as it provides a very elegant solution to the nagging strong CP-problem associated with the THETA vacuum structure of QCD. However, particle physics gives little guidance as to the axion mass; a priori, the plausible values span the range: 10/sup /minus/12/ eV /approx lt/ m/sub a/ /approx lt/ 10/sup 6/ eV, some 18 orders-of-magnitude. Axions have a host of interesting astrophysical and cosmological effects, including, modifying the evolution of stars of all types (our sun, red giants, white dwarfs, and neutron stars), contributing significantly to the mass density of the Universe today, and producing detectable line radiation through the decays of relic axions. Consideration of these effects has probed 14 orders-of-magnitude in axion mass, and has left open only two windows for further exploration: 10/sup /minus/6/ eV /approx lt/ m/sub a/ /approx lt/ 10/sup /minus/3/ eV and 1 eV /approx lt/ m/sub a/ /approx lt/ 5 eV (hadronic axions only). Both these windows are accessible to experiment, and a variety of very interesting experiments, all of which involve ''heavenly axions,'' are being planned or are underway. 58 refs., 6 figs., 1 tab.

  10. Dead time effect on single photon counting for the longitudinal density monitor of LHC

    CERN Document Server

    Bravin, E

    2005-01-01

    The longitudinal distribution of the protons in the two LHC rings needs to be known with high accuracy. This is required for both: the correct operation of the machine and the understanding of beam dynamics effects that can influence the performances of the collider. One possible way of achieving the required time resolution of 50 ps and dynamic range of 10.4 is single photons counting of the synchrotron radiation emitted by the beams using avalanche photo diodes (APDs). Although this kind of devices have very short rise times and allow precise time stamping of detected photons, they also have long recovery times (dead time) of the order of hundreds of nanoseconds, much longer than the bunch length of the LHC beams. For this reason it is important to evaluate the masking effect introduced by this dead time, where photons emitted by protons in different longitudinal positions will have different probabilities of being detected.

  11. Dead time effect on single photon counting for the longitudinal density monitor LHC

    CERN Document Server

    Bravin, E

    2005-01-01

    The longitudinal distribution of the protons in the two LHC rings needs to be known with high accuracy. This is required for both: the correct operation of the machine and the understanding of beam dynamics effects that can influence the performances of the collider. One possible way of achieving the required time resolution of 50 ps and dynamic range of 10.4 is single photons counting of the synchrotron radiation emitted by the beams using avalanche photo diodes (APDs). Although this kind of devices have very short rise times and allow precise time stamping of detected photons, they also have long recovery times (dead time) of the order of humdreds of nanoseconds, much longer than the bunch length of the LHC beams. For this reason it is important to evaluate the masking effect introduced by this dead time, where photons emitted by protons in different longitudinal positions will have different probabilities of being detected.

  12. Working with Windows 7 at CERN (EN)

    CERN Multimedia

    CERN. Geneva

    2010-01-01

    Overview of new concepts and user interface changes in Windows 7 as compared with older versions of Windows: XP or Vista. Availability of Windows 7 at CERN and its integration with CERN Windows infrastructure will be discussed.

  13. Long term monitoring of window opening behaviour in Danish dwellings

    DEFF Research Database (Denmark)

    Andersen, Rune Vinther; Toftum, Jørn; Olesen, Bjarne W.

    2009-01-01

    with the findings in the literature. The measured variables just prior to an opening/closing event were compared to variables where no events occurred. Indoor air quality and solar radiation where found to be the main drivers in the occupants’ determination of when to open a window. The indoor air quality...... and outdoor temperature affected when the window was closed and finally the time of day had an impact on the window opening behaviour of the occupants....

  14. Real-Time Single Frequency Precise Point Positioning Using SBAS Corrections

    Directory of Open Access Journals (Sweden)

    Liang Li

    2016-08-01

    Full Text Available Real-time single frequency precise point positioning (PPP is a promising technique for high-precision navigation with sub-meter or even centimeter-level accuracy because of its convenience and low cost. The navigation performance of single frequency PPP heavily depends on the real-time availability and quality of correction products for satellite orbits and satellite clocks. Satellite-based augmentation system (SBAS provides the correction products in real-time, but they are intended to be used for wide area differential positioning at 1 meter level precision. By imposing the constraints for ionosphere error, we have developed a real-time single frequency PPP method by sufficiently utilizing SBAS correction products. The proposed PPP method are tested with static and kinematic data, respectively. The static experimental results show that the position accuracy of the proposed PPP method can reach decimeter level, and achieve an improvement of at least 30% when compared with the traditional SBAS method. The positioning convergence of the proposed PPP method can be achieved in 636 epochs at most in static mode. In the kinematic experiment, the position accuracy of the proposed PPP method can be improved by at least 20 cm relative to the SBAS method. Furthermore, it has revealed that the proposed PPP method can achieve decimeter level convergence within 500 s in the kinematic mode.

  15. NONLINEAR SYSTEM MODELING USING SINGLE NEURON CASCADED NEURAL NETWORK FOR REAL-TIME APPLICATIONS

    Directory of Open Access Journals (Sweden)

    S. Himavathi

    2012-04-01

    Full Text Available Neural Networks (NN have proved its efficacy for nonlinear system modeling. NN based controllers and estimators for nonlinear systems provide promising alternatives to the conventional counterpart. However, NN models have to meet the stringent requirements on execution time for its effective use in real time applications. This requires the NN model to be structurally compact and computationally less complex. In this paper a parametric method of analysis is adopted to determine the compact and faster NN model among various neural network architectures. This work proves through analysis and examples that the Single Neuron Cascaded (SNC architecture is distinct in providing compact and simpler models requiring lower execution time. The unique structural growth of SNC architecture enables automation in design. The SNC Network is shown to combine the advantages of both single and multilayer neural network architectures. Extensive analysis on selected architectures and their models for four benchmark nonlinear theoretical plants and a practical application are tested. A performance comparison of the NN models is presented to demonstrate the superiority of the single neuron cascaded architecture for online real time applications.

  16. Reduction in the ionospheric error for a single-frequency GPS timing solution using tomography

    Directory of Open Access Journals (Sweden)

    Cathryn N. Mitchell

    2009-06-01

    Full Text Available

    Times;">Abstract

    Times;">Single-frequency Global Positioning System (GPS receivers do not accurately compensate for the ionospheric delay imposed upon a GPS signal. They rely upon models to compensate for the ionosphere. This delay compensation can be improved by measuring it directly with a dual-frequency receiver, or by monitoring the ionosphere using real-time maps. This investigation uses a 4D tomographic algorithm, Multi Instrument Data Analysis System (MIDAS, to correct for the ionospheric delay and compares the results to existing single and dualfrequency techniques. Maps of the ionospheric electron density, across Europe, are produced by using data collected from a fixed network of dual-frequency GPS receivers. Single-frequency pseudorange observations are corrected by using the maps to find the excess propagation delay on the GPS L1 signals. Days during the solar maximum year 2002 and the October 2003 storm have been chosen to display results when the ionospheric delays are large and variable. Results that improve upon the use of existing ionospheric models are achieved by applying MIDAS to fixed and mobile single-frequency GPS timing solutions. The approach offers the potential for corrections to be broadcast over a local region, or provided via the internet and allows timing accuracies to within 10 ns to be achieved.



  17. Measurement of the Rise-Time in a Single Sided Ladder Detector

    International Nuclear Information System (INIS)

    Gerber, C.E.

    1997-01-01

    In this note we report on the measurement of the preamplifier output rise time for a SVXII chip mounted on a D0 single sided ladder. The measurements were performed on the ladder 001-883-L, using the laser test stand of Lab D. The rise time was measured for different values of the response (or bandwidth) of the preamplifier. As a bigger bandwidth results in longer rise times and therefore in less noise, the largest possible bandwidth consistent with the time between bunch crossings should be chosen to operate the detectors. The rise time is defined as the time elapsed between 10% and 90% of the charge is collected. It is also interesting to measure the time for full charge collection and the percentage of charge collected in 132 ns and 396 ns. The results are shown in table 1, for bandwidths between 2 and 63 (binary numbers). The uncertainty on the time measurement is considered to be ∼ 10 ns. Figure 1 schematically defines the four quantities measured: rise time, time of full charge collection, and percentage of charge collected in 132 ns and 396 ns. Figures 2 to 8 are the actual measurements for bandwidths of 2, 4, 8, 12, 24, 32 and 63. Figure 9 is a second measurement for BW=24, used as a consistency check of the system and the time measurement performed on the plots. The data indicate that the single sided ladders can be operated at BW=63 for 396 ns and BW=12 for 132 ns, achieving full charge collection. This will result in smaller noise than originally anticipated.

  18. Single-Particle Time-of-Flight Mass Spectrometry Utilizing a Femtosecond Desorption and Ionization Laser.

    Science.gov (United States)

    Zawadowicz, Maria A; Abdelmonem, Ahmed; Mohr, Claudia; Saathoff, Harald; Froyd, Karl D; Murphy, Daniel M; Leisner, Thomas; Cziczo, Daniel J

    2015-12-15

    Single-particle time-of-flight mass spectrometry has now been used since the 1990s to determine particle-to-particle variability and internal mixing state. Instruments commonly use 193 nm excimer or 266 nm frequency-quadrupled Nd:YAG lasers to ablate and ionize particles in a single step. We describe the use of a femtosecond laser system (800 nm wavelength, 100 fs pulse duration) in combination with an existing single-particle time-of-flight mass spectrometer. The goal of this project was to determine the suitability of a femtosecond laser for single-particle studies via direct comparison to the excimer laser (193 nm wavelength, ∼10 ns pulse duration) usually used with the instrument. Laser power, frequency, and polarization were varied to determine the effect on mass spectra. Atmospherically relevant materials that are often used in laboratory studies, ammonium nitrate and sodium chloride, were used for the aerosol. Detection of trace amounts of a heavy metal, lead, in an ammonium nitrate matrix was also investigated. The femtosecond ionization had a large air background not present with the 193 nm excimer and produced more multiply charged ions. Overall, we find that femtosecond laser ablation and ionization of aerosol particles is not radically different than that provided by a 193 nm excimer.

  19. Single trial time-frequency domain analysis of error processing in post-traumatic stress disorder.

    Science.gov (United States)

    Clemans, Zachary A; El-Baz, Ayman S; Hollifield, Michael; Sokhadze, Estate M

    2012-09-13

    Error processing studies in psychology and psychiatry are relatively common. Event-related potentials (ERPs) are often used as measures of error processing, two such response-locked ERPs being the error-related negativity (ERN) and the error-related positivity (Pe). The ERN and Pe occur following committed error in reaction time tasks as low frequency (4-8 Hz) electroencephalographic (EEG) oscillations registered at the midline fronto-central sites. We created an alternative method for analyzing error processing using time-frequency analysis in the form of a wavelet transform. A study was conducted in which subjects with PTSD and healthy control completed a forced-choice task. Single trial EEG data from errors in the task were processed using a continuous wavelet transform. Coefficients from the transform that corresponded to the theta range were averaged to isolate a theta waveform in the time-frequency domain. Measures called the time-frequency ERN and Pe were obtained from these waveforms for five different channels and then averaged to obtain a single time-frequency ERN and Pe for each error trial. A comparison of the amplitude and latency for the time-frequency ERN and Pe between the PTSD and control group was performed. A significant group effect was found on the amplitude of both measures. These results indicate that the developed single trial time-frequency error analysis method is suitable for examining error processing in PTSD and possibly other psychiatric disorders. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  20. Novel algorithm and MATLAB-based program for automated power law analysis of single particle, time-dependent mean-square displacement

    Science.gov (United States)

    Umansky, Moti; Weihs, Daphne

    2012-08-01

    should also be backwards compatible. Symbolic Math Toolboxes (5.5) is required. The Curve Fitting Toolbox (3.0) is recommended. Computer: Tested on Windows only, yet should work on any computer running MATLAB. In Windows 7, should be used as administrator, if the user is not the administrator the program may not be able to save outputs and temporary outputs to all locations. Operating system: Any supporting MATLAB (MathWorks Inc.) v7.11 / 2010b or higher. Supplementary material: Sample output files (approx. 30 MBytes) are available. Classification: 12 External routines: Several MATLAB subfunctions (m-files), freely available on the web, were used as part of and included in, this code: count, NaN suite, parseArgs, roundsd, subaxis, wcov, wmean, and the executable pdfTK.exe. Nature of problem: In many physical and biophysical areas employing single-particle tracking, having the time-dependent power-laws governing the time-averaged meansquare displacement (MSD) of a single particle is crucial. Those power laws determine the mode-of-motion and hint at the underlying mechanisms driving motion. Accurate determination of the power laws that describe each trajectory will allow categorization into groups for further analysis of single trajectories or ensemble analysis, e.g. ensemble and time-averaged MSD. Solution method: The algorithm in the provided program automatically analyzes and fits time-dependent power laws to single particle trajectories, then group particles according to user defined cutoffs. It accepts time-dependent trajectories of several particles, each trajectory is run through the program, its time-averaged MSD is calculated, and power laws are determined in regions where the MSD is linear on a log-log scale. Our algorithm searches for high-curvature points in experimental data, here time-dependent MSD. Those serve as anchor points for determining the ranges of the power-law fits. Power-law scaling is then accurately determined and error estimations of the

  1. Single-photon detectors combining high efficiency, high detection rates, and ultra-high timing resolution

    Directory of Open Access Journals (Sweden)

    Iman Esmaeil Zadeh

    2017-11-01

    Full Text Available Single-photon detection with high efficiency, high time resolution, low dark counts, and high photon detection rates is crucial for a wide range of optical measurements. Although efficient detectors have been reported before, combining all performance parameters in a single device remains a challenge. Here, we show a broadband NbTiN superconducting nanowire detector with an efficiency exceeding 92%, over 150 MHz photon detection rate, and a dark count rate below 130 Hz operated in a Gifford-McMahon cryostat. Furthermore, with careful optimization of the detector design and readout electronics, we reach an ultra-low system timing jitter of 14.80 ps (13.95 ps decoupled while maintaining high detection efficiencies (>75%.

  2. Memory effect in silicon time-gated single-photon avalanche diodes

    Energy Technology Data Exchange (ETDEWEB)

    Dalla Mora, A.; Contini, D., E-mail: davide.contini@polimi.it; Di Sieno, L. [Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133 Milano (Italy); Tosi, A.; Boso, G.; Villa, F. [Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133 Milano (Italy); Pifferi, A. [Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133 Milano (Italy); CNR, Istituto di Fotonica e Nanotecnologie, Piazza Leonardo da Vinci 32, I-20133 Milano (Italy)

    2015-03-21

    We present a comprehensive characterization of the memory effect arising in thin-junction silicon Single-Photon Avalanche Diodes (SPADs) when exposed to strong illumination. This partially unknown afterpulsing-like noise represents the main limiting factor when time-gated acquisitions are exploited to increase the measurement dynamic range of very fast (picosecond scale) and faint (single-photon) optical signals following a strong stray one. We report the dependences of this unwelcome signal-related noise on photon wavelength, detector temperature, and biasing conditions. Our results suggest that this so-called “memory effect” is generated in the deep regions of the detector, well below the depleted region, and its contribution on detector response is visible only when time-gated SPADs are exploited to reject a strong burst of photons.

  3. Time domain spectral phase encoding/DPSK data modulation using single phase modulator for OCDMA application.

    Science.gov (United States)

    Wang, Xu; Gao, Zhensen; Kataoka, Nobuyuki; Wada, Naoya

    2010-05-10

    A novel scheme using single phase modulator for simultaneous time domain spectral phase encoding (SPE) signal generation and DPSK data modulation is proposed and experimentally demonstrated. Array- Waveguide-Grating and Variable-Bandwidth-Spectrum-Shaper based devices can be used for decoding the signal directly in spectral domain. The effects of fiber dispersion, light pulse width and timing error on the coding performance have been investigated by simulation and verified in experiment. In the experiment, SPE signal with 8-chip, 20GHz/chip optical code patterns has been generated and modulated with 2.5 Gbps DPSK data using single modulator. Transmission of the 2.5 Gbps data over 34km fiber with BEROCDMA) and secure optical communication applications. (c) 2010 Optical Society of America.

  4. Reduction In Setup Time By Single Minute Exchange Of Dies SMED Methodology

    Directory of Open Access Journals (Sweden)

    Pallavi A. Gade

    2015-08-01

    Full Text Available Life is a race if you dont chase it someone is definitely chase you and will go ahead. Hence to survive in todays business world every manufacturer has to have some idea and plans for their betterment. Market scenario has nearly change after 1990s that every manufacturer must go through the global competition demand for short lead time demand for variety small lot sizes and also proliferation of OEMs. If we have to increase the frequency of delivery without compromising the quality Single Minute Exchange of Dies is the answer. Single Minute Exchange of Dies is not only apply to bottleneck machines it is to be implemented company wide and aim must be to bring all setup time to less than ten minutes in this paper some techniques basic procedure problems faced by companies are discussed and solution for them are suggested.

  5. Time profile of harmonics generated by a single atom in a strong electromagnetic field

    International Nuclear Information System (INIS)

    Antoine, P.; Piraux, B.; Maquet, A.

    1995-01-01

    We show that the time profile of the harmonics emitted by a single atom exposed to a strong electromagnetic field may be obtained through a wavelet or a Gabor analysis of the acceleration of the atomic dipole. This analysis is extremely sensitive to the details of the dynamics and sheds some light on the competition between the atomic excitation or ionization processes and photon emission. For illustration we study the interaction of atomic hydrogen with an intense laser pulse

  6. Rise time of voltage pulses in NbN superconducting single photon detectors

    International Nuclear Information System (INIS)

    Smirnov, K. V.; Divochiy, A. V.; Karpova, U. V.; Morozov, P. V.; Vakhtomin, Yu. B.; Seleznev, V. A.; Sidorova, M. V.; Zotova, A. N.; Vodolazov, D. Yu.

    2016-01-01

    We have found experimentally that the rise time of voltage pulse in NbN superconducting single photon detectors increases nonlinearly with increasing the length of the detector L. The effect is connected with dependence of resistance of the detector R n , which appears after photon absorption, on its kinetic inductance L k and, hence, on the length of the detector. This conclusion is confirmed by our calculations in the framework of two temperature model.

  7. Rise time of voltage pulses in NbN superconducting single photon detectors

    Energy Technology Data Exchange (ETDEWEB)

    Smirnov, K. V. [Moscow State Pedagogical University, 1 Malaya Pirogovskaya St., 119435 Moscow (Russian Federation); CJSC “Superconducting Nanotechnology” (Scontel), 5/22-1 Rossolimo St., 119021 Moscow (Russian Federation); National Research University Higher School of Economics, Moscow Institute of Electronics and Mathematics, 34 Tallinskaya St., 109028 Moscow (Russian Federation); Divochiy, A. V.; Karpova, U. V.; Morozov, P. V. [CJSC “Superconducting Nanotechnology” (Scontel), 5/22-1 Rossolimo St., 119021 Moscow (Russian Federation); Vakhtomin, Yu. B.; Seleznev, V. A. [Moscow State Pedagogical University, 1 Malaya Pirogovskaya St., 119435 Moscow (Russian Federation); CJSC “Superconducting Nanotechnology” (Scontel), 5/22-1 Rossolimo St., 119021 Moscow (Russian Federation); Sidorova, M. V. [Moscow State Pedagogical University, 1 Malaya Pirogovskaya St., 119435 Moscow (Russian Federation); Zotova, A. N.; Vodolazov, D. Yu. [Institute for Physics of Microstructure, Russian Academy of Sciences, GSP-105, 603950 Nizhny Novgorod (Russian Federation); Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Avenue, 603950 Nizhny Novgorod (Russian Federation)

    2016-08-01

    We have found experimentally that the rise time of voltage pulse in NbN superconducting single photon detectors increases nonlinearly with increasing the length of the detector L. The effect is connected with dependence of resistance of the detector R{sub n}, which appears after photon absorption, on its kinetic inductance L{sub k} and, hence, on the length of the detector. This conclusion is confirmed by our calculations in the framework of two temperature model.

  8. The workplace window view

    DEFF Research Database (Denmark)

    Lottrup, Lene Birgitte Poulsen; Stigsdotter, Ulrika K.; Meilby, Henrik

    2015-01-01

    Office workers’ job satisfaction and ability to work are two important factors for the viability and competitiveness of most companies, and existing studies in contexts other than workplaces show relationships between a view of natural elements and, for example, student performance...... and neighbourhood satisfaction. This study investigates whether relationships between window view, and work ability and job satisfaction also exist in the context of the workplace by focusing on office workers’ view satisfaction. The results showed that a view of natural elements was related to high view...... satisfaction, and that high view satisfaction was related to high work ability and high job satisfaction. Furthermore, the results indicated that job satisfaction mediated the effect of view satisfaction on work ability. These findings show that a view of a green outdoor environment at the workplace can...

  9. Beam line windows at LAMPF

    International Nuclear Information System (INIS)

    Brown, R.D.; Grisham, D.L.; Lambert, J.E.

    1985-01-01

    The A-6 main beam-line window at LAMPF separates the vacuum of the main beam line from the isotope production station, proton irradiation ports, and the beam stop, which operate in air. This window must withstand the design beam current of 1 mA at 800 MeV for periods of at least 3000 hours without failure. The window is water cooled and must be strong enough to withstand the 2.1 MPa (300 psig) cooling water pressure, as well as beam-induced thermal stresses. Two designs have been used to meet these goals, a stepped-plate window and a hemispherical window, both made from a precipitation-hardened nickel base alloy, Alloy 718. Calculations of the temperatures and stresses in each of these windows are presented

  10. Windows with improved energy performance

    DEFF Research Database (Denmark)

    Noyé, Peter Anders; Laustsen, Jacob Birck; Svendsen, Svend

    2002-01-01

    . Heat loss through windows represents a considerably part of the total heat loss from houses. However windows provide a unique potential of solar energy gain to the building besides from providing daylight access and view. This results in a need for development of windows with improved energy...... performances. During the last 20 years the U-value of the glazing part of windows has been improved considerably, but the frame part has not followed the same development with respect to energy performance. Therefore an increasingly large part of the total heat loss through windows is relating to the frame...... part, for which reason, as far as energy efficiency and total economy are concerned, it has become more interesting to further develop frame structures. Traditionally, the energy performance of windows has primarily been characterised by the heat loss coefficient, U-value. However as the heat loss has...

  11. Improved Windows for Cold Climates

    DEFF Research Database (Denmark)

    Laustsen, Jacob Birck; Svendsen, Svend

    2005-01-01

    A large part of the energy consumption in countries in Nordic and Arctic climates is used for space heating in buildings. In typical buildings the windows are responsible for a con-siderable part of the heat losses. Therefore there is a large potential for energy savings by developing and using...... windows with improved energy performance. Traditionally evaluation of the energy performance of windows has focused on the thermal transmittance, but as windows differ from the rest of the building envelope by allowing solar energy to enter the building, the total solar energy transmittance is equally...... important. In the heating season in cold climates the solar gain through windows can be utilized for space heating which results in a corresponding reduction in the energy production that is often based on fossil fuels. A suitable quantity for evaluating the energy performance of windows in a simple...

  12. Optically transmissive window on ITER port cell door

    International Nuclear Information System (INIS)

    Patel, Kunal; Walsh, Mike; Phillips, Guy; Parsons, Phil; Balshaw, Nick; Hank, Simon

    2009-01-01

    In the ITER Thomson Scattering Core LIDAR system there are currently three concepts for collecting scattered light from the plasma and delivering it to the diagnostic room. An option to use a broadband mirror in Cassegrain configuration has been explored. In this concept a large optical window, 1.5 m in diameter, is required in the port cell door. This could be manufactured in a number of ways, including using a single thick window or mosaic arrangement with a supporting structure. Challenges associated with this design include maintaining the secondary confinement barrier, withstanding a pressure differential of 0.5 bar across the window in foreseeable fault conditions, and maintaining the optical properties of the window. It must also be possible to protect the window when work is being carried out in the area. Fracture analysis for brittle material was carried out, for a flaw size with a length to depth ratio of 80/20, which gave a safety reserve factor of 4. The flaw size was based on a standard optical transmissive lens for collection light. A static analysis was carried out on both options of having a single thick glass window or a mosaic arrangement. The principal stress for a single window arrangement is 12 MPa and for a proposed mosaic arrangement is 12.5 MPa. The analyses have demonstrated that a single glass window with a thickness of 42 mm would be mechanically acceptable but expensive to manufacture and it would be difficult to polish glass of that size to lens quality. By comparison in the proposed mosaic window arrangement, the glass thickness is reduced by 50% with the aid of the supporting structure. As a result of the supporting structure the geometrical optical losses are 4%, which are mechanically and optically acceptable, whilst significantly reducing the cost of manufacturing.

  13. Real-time, single-step bioassay using nanoplasmonic resonator with ultra-high sensitivity

    Science.gov (United States)

    Zhang, Xiang; Ellman, Jonathan A; Chen, Fanqing Frank; Su, Kai-Hang; Wei, Qi-Huo; Sun, Cheng

    2014-04-01

    A nanoplasmonic resonator (NPR) comprising a metallic nanodisk with alternating shielding layer(s), having a tagged biomolecule conjugated or tethered to the surface of the nanoplasmonic resonator for highly sensitive measurement of enzymatic activity. NPRs enhance Raman signals in a highly reproducible manner, enabling fast detection of protease and enzyme activity, such as Prostate Specific Antigen (paPSA), in real-time, at picomolar sensitivity levels. Experiments on extracellular fluid (ECF) from paPSA-positive cells demonstrate specific detection in a complex bio-fluid background in real-time single-step detection in very small sample volumes.

  14. Using a single RGB frame for real time 3D hand pose estimation in the wild

    OpenAIRE

    Panteleris, Paschalis; Oikonomidis, Iason; Argyros, Antonis

    2017-01-01

    We present a method for the real-time estimation of the full 3D pose of one or more human hands using a single commodity RGB camera. Recent work in the area has displayed impressive progress using RGBD input. However, since the introduction of RGBD sensors, there has been little progress for the case of monocular color input. We capitalize on the latest advancements of deep learning, combining them with the power of generative hand pose estimation techniques to achieve real-time monocular 3D ...

  15. Non-Markovian theory for the waiting time distributions of single electron transfers.

    Science.gov (United States)

    Welack, Sven; Yan, YiJing

    2009-09-21

    We derive a non-Markovian theory for waiting time distributions of consecutive single electron transfer events. The presented microscopic Pauli rate equation formalism couples the open electrodes to the many-body system, allowing to take finite bias and temperature into consideration. Numerical results reveal transient oscillations of distinct system frequencies due to memory in the waiting time distributions. Memory effects can be approximated by an expansion in non-Markovian corrections. This method is employed to calculate memory landscapes displaying preservation of memory over multiple consecutive electron transfers.

  16. Time-of-flight camera via a single-pixel correlation image sensor

    Science.gov (United States)

    Mao, Tianyi; Chen, Qian; He, Weiji; Dai, Huidong; Ye, Ling; Gu, Guohua

    2018-04-01

    A time-of-flight imager based on single-pixel correlation image sensors is proposed for noise-free depth map acquisition in presence of ambient light. Digital micro-mirror device and time-modulated IR-laser provide spatial and temporal illumination on the unknown object. Compressed sensing and ‘four bucket principle’ method are combined to reconstruct the depth map from a sequence of measurements at a low sampling rate. Second-order correlation transform is also introduced to reduce the noise from the detector itself and direct ambient light. Computer simulations are presented to validate the computational models and improvement of reconstructions.

  17. Real-time analysis and visualization for single-molecule based super-resolution microscopy.

    Directory of Open Access Journals (Sweden)

    Adel Kechkar

    Full Text Available Accurate multidimensional localization of isolated fluorescent emitters is a time consuming process in single-molecule based super-resolution microscopy. We demonstrate a functional method for real-time reconstruction with automatic feedback control, without compromising the localization accuracy. Compatible with high frame rates of EM-CCD cameras, it relies on a wavelet segmentation algorithm, together with a mix of CPU/GPU implementation. A combination with Gaussian fitting allows direct access to 3D localization. Automatic feedback control ensures optimal molecule density throughout the acquisition process. With this method, we significantly improve the efficiency and feasibility of localization-based super-resolution microscopy.

  18. On the thermal inertia and time constant of single-family houses

    Energy Technology Data Exchange (ETDEWEB)

    Hedbrant, J.

    2001-08-01

    Since the 1970s, electricity has become a common heating source in Swedish single-family houses. About one million small houses can use electricity for heating, about 600.000 have electricity as the only heating source, A liberalised European electricity market would most likely raise the Swedish electricity prices during daytime on weekdays and lower it at other times. In the long run, electrical heating of houses would be replaced by fuels, but in the shorter perspective, other strategies may be considered. This report evaluates the use of electricity for heating a dwelling, or part of it, at night when both the demand and the price are low. The stored heat is utilised in the daytime some hours later, when the electricity price is high. Essential for heat storage is the thermal time constant. The report gives a simple theoretical framework for the calculation of the time constant for a single-family house with furniture. Furthermore the comfort time constant, that is, the time for a house to cool down from a maximum to a minimum acceptable temperature, is derived. Two theoretical model houses are calculated, and the results are compared to data from empirical studies in three inhabited test houses. The results show that it was possible to store about 8 kWh/K in a house from the seventies and about 5 kWh/K in a house from the eighties. The time constants were 34 h and 53 h, respectively. During winter conditions with 0 deg C outdoor, the 'comfort' time constants with maximum and minimum indoor temperatures of 23 and 20 deg C were 6 h and 10 h. The results indicate that the maximum load-shifting potential of an average single family house is about 1 kw during 16 daytime hours shifted into 2 kw during 8 night hours. Upscaled to the one million Swedish single-family houses that can use electricity as a heating source, the maximum potential is 1000 MW daytime time-shifted into 2000 MW at night.

  19. Iterative algorithms to approximate canonieal Gabor windows: Computational aspects

    DEFF Research Database (Denmark)

    Janssen, A. J. E. M.; Søndergaard, Peter Lempel

    2007-01-01

    In this article we investigate the computational aspects of some recently proposed iterative methods for approximating the canonical tight and canonical dual window of a Gabor frame (g, a, b). The iterations start with the window g while the iteration steps comprise the window g, the k(th) iterand...... convergence constants. The iteratious, initially formulated for time-continuous Gabor systems, are considered and tested in a discrete setting in which one passes to the appropriately sampled-and-periodized windows and frame operators. Furthermore, they are compared with respect to accuracy and efficiency...

  20. Iterative algorithms to approximate canonical Gabor windows: Computational aspects

    DEFF Research Database (Denmark)

    Janssen, A.J.E.M; Søndergaard, Peter Lempel

    In this paper we investigate the computational aspects of some recently proposed iterative methods for approximating the canonical tight and canonical dual window of a Gabor frame (g,a,b). The iterations start with the window g while the iteration steps comprise the window g, the k^th iterand...... convergence constants. The iterations, initially formulated for time-continuous Gabor systems, are considered and tested in a discrete setting in which one passes to the appropriately sampled-and-periodized windows and frame operators. Furthermore, they are compared with respect to accuracy and efficiency...

  1. Windows 7 The Missing Manual

    CERN Document Server

    Pogue, David

    2010-01-01

    In early reviews, geeks raved about Windows 7. But if you're an ordinary mortal, learning what this new system is all about will be challenging. Fear not: David Pogue's Windows 7: The Missing Manual comes to the rescue. Like its predecessors, this book illuminates its subject with reader-friendly insight, plenty of wit, and hardnosed objectivity for beginners as well as veteran PC users. Windows 7 fixes many of Vista's most painful shortcomings. It's speedier, has fewer intrusive and nagging screens, and is more compatible with peripherals. Plus, Windows 7 introduces a slew of new features,

  2. Subject Responses to Electrochromic Windows

    Energy Technology Data Exchange (ETDEWEB)

    Clear, Robert; Inkarojrit, Vorapat; Lee, Eleanor

    2006-03-03

    Forty-three subjects worked in a private office with switchable electrochromic windows, manually-operated Venetian blinds, and dimmable fluorescent lights. The electrochromic window had a visible transmittance range of approximately 3-60%. Analysis of subject responses and physical data collected during the work sessions showed that the electrochromic windows reduced the incidence of glare compared to working under a fixed transmittance (60%) condition. Subjects used the Venetian blinds less often and preferred the variable transmittance condition, but used slightly more electric lighting with it than they did when window transmittance was fixed.

  3. Live histograms in moving windows

    International Nuclear Information System (INIS)

    Zhil'tsov, V.E.

    1989-01-01

    Application of computer graphics for specific hardware testing is discussed. The hardware is position sensitive detector (multiwire proportional chamber) which is used in high energy physics experiments, and real-out electronics for it. Testing program is described (XPERT), which utilises multi-window user interface. Data are represented as histograms in windows. The windows on the screen may be moved, reordered, their sizes may be changed. Histograms may be put to any window, and hardcopy may be made. Some program internals are discussed. The computer environment is quite simple: MS-DOS IBM PC/XT, 256 KB RAM, CGA, 5.25'' FD, Epson MX. 4 refs.; 7 figs

  4. Microsoft Windows Operating System Essentials

    CERN Document Server

    Carpenter, Tom

    2012-01-01

    A full-color guide to key Windows 7 administration concepts and topics Windows 7 is the leading desktop software, yet it can be a difficult concept to grasp, especially for those new to the field of IT. Microsoft Windows Operating System Essentials is an ideal resource for anyone new to computer administration and looking for a career in computers. Delving into areas such as fundamental Windows 7 administration concepts and various desktop OS topics, this full-color book addresses the skills necessary for individuals looking to break into a career in IT. Each chapter begins with a list of topi

  5. Beginning Windows 8.1

    CERN Document Server

    Halsey, Mike

    2013-01-01

    Windows 8 has been described by Microsoft as its 'boldest' Windows release ever and the 8.1 update enhances the paradigm further. Beginning Windows 8.1 takes you through the new features and helps you get more out of the familiar to reveal the fullest possibilities for this amazing new operating system. You will learn, with non-technical language used throughout, how to get up and running in the new Windows interface, minimize downtime, maximize productivity, and harness the features you never knew existed to take control of your computer and enjoy the peace of mind and excitement that comes w

  6. Windows 7 the definitive guide

    CERN Document Server

    Stanek, William R

    2010-01-01

    This book provides everything you need to manage and maintain Windows 7. You'll learn all of the features and enhancements in complete detail, along with specifics for configuring the operating system to put you in full control. Bestselling author and Windows expert William Stanek doesn't just show you the steps you need to follow, he also tells you how features work, why they work, and how you can customize them to meet your needs. Learn how to squeeze every bit of power out of Windows 7 to take full advantage of its features and programs. Set up, customize, and tune Windows 7-Optimize its

  7. The Discharge Coefficient of a Centre-Pivot Roof Window

    DEFF Research Database (Denmark)

    Iqbal, Ahsan; Afshari, Alireza; Nielsen, Peter V.

    2012-01-01

    Accuracy in estimation of airflow through windows is the key parameter for modelling and designing of naturally ventilated buildings. The flow through windows is usually described by the orifice flow plate equation. This equation involves the discharge coefficient. In practice, often a constant...... value of discharge coefficient is used. The constant value of discharge coefficient leads to deceptive airflow estimation in the cases of centre-pivot roof windows. The object of this paper is to study and evaluate the discharge coefficient of the centre pivot roof window. Focus is given...... on unidirectional flows i.e. inflow and outflow. CFD techniques are used to predict the airflow through the modelled window. Analytical orifice flow equation is used to calculate the discharge coefficient. Results are compared with experimental results. It is concluded that the single value of the discharge...

  8. Extending single molecule fluorescence observation time by amplitude-modulated excitation

    Science.gov (United States)

    Kisley, Lydia; Chang, Wei-Shun; Cooper, David; Mansur, Andrea P.; Landes, Christy F.

    2013-09-01

    We present a hardware-based method that can improve single molecule fluorophore observation time by up to 1500% and super-localization by 47% for the experimental conditions used. The excitation was modulated using an acousto-optic modulator (AOM) synchronized to the data acquisition and inherent data conversion time of the detector. The observation time and precision in super-localization of four commonly used fluorophores were compared under modulated and traditional continuous excitation, including direct total internal reflectance excitation of Alexa 555 and Cy3, non-radiative Förster resonance energy transfer (FRET) excited Cy5, and direct epi-fluorescence wide field excitation of Rhodamine 6G. The proposed amplitude-modulated excitation does not perturb the chemical makeup of the system or sacrifice signal and is compatible with multiple types of fluorophores. Amplitude-modulated excitation has practical applications for any fluorescent study utilizing an instrumental setup with time-delayed detectors.

  9. Extending single molecule fluorescence observation time by amplitude-modulated excitation

    International Nuclear Information System (INIS)

    Kisley, Lydia; Chang, Wei-Shun; Cooper, David; Mansur, Andrea P; Landes, Christy F

    2013-01-01

    We present a hardware-based method that can improve single molecule fluorophore observation time by up to 1500% and super-localization by 47% for the experimental conditions used. The excitation was modulated using an acousto-optic modulator (AOM) synchronized to the data acquisition and inherent data conversion time of the detector. The observation time and precision in super-localization of four commonly used fluorophores were compared under modulated and traditional continuous excitation, including direct total internal reflectance excitation of Alexa 555 and Cy3, non-radiative Förster resonance energy transfer (FRET) excited Cy5, and direct epi-fluorescence wide field excitation of Rhodamine 6G. The proposed amplitude-modulated excitation does not perturb the chemical makeup of the system or sacrifice signal and is compatible with multiple types of fluorophores. Amplitude-modulated excitation has practical applications for any fluorescent study utilizing an instrumental setup with time-delayed detectors. (technical note)

  10. An Efficient Channel Model for OFDM and Time Domain Single Carrier Transmission Using Impulse Responses

    Directory of Open Access Journals (Sweden)

    Tariq Jamil Saifullah Khanzada

    2012-01-01

    Full Text Available The OFDM (Orthogonal Frequency Division Multiplexing is well-known, most utilized wideband communication technique of the current era. SCT (Single Carrier Transmission provides equivalent performance in time domain while decision equalizer is implemented in frequency domain. SCT annihilates the ICT (Inter Carrier Interference and the PAPR (Peak to Average Power Ratio which is inherent to OFDM and degrades its performance in time varying channels. An efficient channel model is presented in this contribution, to implement OFDM and SCT in time domain using impulse responses. Both OFDM and SCT models are derived dialectically to model the channel impulse responses. Our model enhances the performance of time domain SCT compared with OFDM and subsides the PAPR and ICI problems of OFDM. SCT is implemented at symbol level contained in blocks. Simulation results implementing Digital Radio Monadiale (DRM assert the performance gain of SCT over OFDM.

  11. Mixed response and time-to-event endpoints for multistage single-arm phase II design.

    Science.gov (United States)

    Lai, Xin; Zee, Benny Chung-Ying

    2015-06-04

    The objective of phase II cancer clinical trials is to determine if a treatment has sufficient activity to warrant further study. The efficiency of a conventional phase II trial design has been the object of considerable debate, particularly when the study regimen is characteristically cytostatic. At the time of development of a phase II cancer trial, we accumulated clinical experience regarding the time to progression (TTP) for similar classes of drugs and for standard therapy. By considering the time to event (TTE) in addition to the tumor response endpoint, a mixed-endpoint phase II design may increase the efficiency and ability of selecting promising cytotoxic and cytostatic agents for further development. We proposed a single-arm phase II trial design by extending the Zee multinomial method to fully use mixed endpoints with tumor response and the TTE. In this design, the dependence between the probability of response and the TTE outcome is modeled through a Gaussian copula. Given the type I and type II errors and the hypothesis as defined by the response rate (RR) and median TTE, such as median TTP, the decision rules for a two-stage phase II trial design can be generated. We demonstrated through simulation that the proposed design has a smaller expected sample size and higher early stopping probability under the null hypothesis than designs based on a single-response endpoint or a single TTE endpoint. The proposed design is more efficient for screening new cytotoxic or cytostatic agents and less likely to miss an effective agent than the alternative single-arm design.

  12. Masked repetition and translation priming in second language learners: a window on the time-course of form and meaning activation using erps.

    Science.gov (United States)

    Midgley, Katherine J; Holcomb, Phillip J; Grainger, Jonathan

    2009-05-01

    Event-related potentials (ERPs) and masked translation priming served to examine the time-course of form and meaning activation during word recognition in second language learners. Targets were repetitions of, translations of, or were unrelated to the immediately preceding prime. In Experiment 1 all targets were in the participants' L2. In Experiment 2 all targets were in the participants' L1. In Exp 1 both within-language repetition and L1-L2 translation priming produced effects on the N250 component and the N400 component. In Experiment 2 only within-language repetition produced N250 effects, while both types of priming produced N400 effects. These results suggest rapid involvement of semantic representations during on-going form-level processing of printed words, and an absence of facilitatory connections between the form representations of non-cognate translation equivalents in L2 learners. The implications for bilingual theories of word processing are discussed.

  13. Windows forensic analysis toolkit advanced analysis techniques for Windows 7

    CERN Document Server

    Carvey, Harlan

    2012-01-01

    Now in its third edition, Harlan Carvey has updated "Windows Forensic Analysis Toolkit" to cover Windows 7 systems. The primary focus of this edition is on analyzing Windows 7 systems and on processes using free and open-source tools. The book covers live response, file analysis, malware detection, timeline, and much more. The author presents real-life experiences from the trenches, making the material realistic and showing the why behind the how. New to this edition, the companion and toolkit materials are now hosted online. This material consists of electronic printable checklists, cheat sheets, free custom tools, and walk-through demos. This edition complements "Windows Forensic Analysis Toolkit, 2nd Edition", (ISBN: 9781597494229), which focuses primarily on XP. It includes complete coverage and examples on Windows 7 systems. It contains Lessons from the Field, Case Studies, and War Stories. It features companion online material, including electronic printable checklists, cheat sheets, free custom tools, ...

  14. Optimization of NANOGrav's time allocation for maximum sensitivity to single sources

    International Nuclear Information System (INIS)

    Christy, Brian; Anella, Ryan; Lommen, Andrea; Camuccio, Richard; Handzo, Emma; Finn, Lee Samuel

    2014-01-01

    Pulsar timing arrays (PTAs) are a collection of precisely timed millisecond pulsars (MSPs) that can search for gravitational waves (GWs) in the nanohertz frequency range by observing characteristic signatures in the timing residuals. The sensitivity of a PTA depends on the direction of the propagating GW source, the timing accuracy of the pulsars, and the allocation of the available observing time. The goal of this paper is to determine the optimal time allocation strategy among the MSPs in the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) for a single source of GW under a particular set of assumptions. We consider both an isotropic distribution of sources across the sky and a specific source in the Virgo cluster. This work improves on previous efforts by modeling the effect of intrinsic spin noise for each pulsar. We find that, in general, the array is optimized by maximizing time spent on the best-timed pulsars, with sensitivity improvements typically ranging from a factor of 1.5 to 4.

  15. Acceleration for 2D time-domain elastic full waveform inversion using a single GPU card

    Science.gov (United States)

    Jiang, Jinpeng; Zhu, Peimin

    2018-05-01

    Full waveform inversion (FWI) is a challenging procedure due to the high computational cost related to the modeling, especially for the elastic case. The graphics processing unit (GPU) has become a popular device for the high-performance computing (HPC). To reduce the long computation time, we design and implement the GPU-based 2D elastic FWI (EFWI) in time domain using a single GPU card. We parallelize the forward modeling and gradient calculations using the CUDA programming language. To overcome the limitation of relatively small global memory on GPU, the boundary saving strategy is exploited to reconstruct the forward wavefield. Moreover, the L-BFGS optimization method used in the inversion increases the convergence of the misfit function. A multiscale inversion strategy is performed in the workflow to obtain the accurate inversion results. In our tests, the GPU-based implementations using a single GPU device achieve >15 times speedup in forward modeling, and about 12 times speedup in gradient calculation, compared with the eight-core CPU implementations optimized by OpenMP. The test results from the GPU implementations are verified to have enough accuracy by comparing the results obtained from the CPU implementations.

  16. 8-channel acquisition system for time-correlated single-photon counting

    Science.gov (United States)

    Antonioli, S.; Miari, L.; Cuccato, A.; Crotti, M.; Rech, I.; Ghioni, M.

    2013-06-01

    Nowadays, an increasing number of applications require high-performance analytical instruments capable to detect the temporal trend of weak and fast light signals with picosecond time resolution. The Time-Correlated Single-Photon Counting (TCSPC) technique is currently one of the preferable solutions when such critical optical signals have to be analyzed and it is fully exploited in biomedical and chemical research fields, as well as in security and space applications. Recent progress in the field of single-photon detector arrays is pushing research towards the development of high performance multichannel TCSPC systems, opening the way to modern time-resolved multi-dimensional optical analysis. In this paper we describe a new 8-channel high-performance TCSPC acquisition system, designed to be compact and versatile, to be used in modern TCSPC measurement setups. We designed a novel integrated circuit including a multichannel Time-to-Amplitude Converter with variable full-scale range, a D/A converter, and a parallel adder stage. The latter is used to adapt each converter output to the input dynamic range of a commercial 8-channel Analog-to-Digital Converter, while the integrated DAC implements the dithering technique with as small as possible area occupation. The use of this monolithic circuit made the design of a scalable system of very small dimensions (95 × 40 mm) and low power consumption (6 W) possible. Data acquired from the TCSPC measurement are digitally processed and stored inside an FPGA (Field-Programmable Gate Array), while a USB transceiver allows real-time transmission of up to eight TCSPC histograms to a remote PC. Eventually, the experimental results demonstrate that the acquisition system performs TCSPC measurements with high conversion rate (up to 5 MHz/channel), extremely low differential nonlinearity (<0.04 peak-to-peak of the time bin width), high time resolution (down to 20 ps Full-Width Half-Maximum), and very low crosstalk between channels.

  17. Timing the start of division in E. coli: a single-cell study

    Science.gov (United States)

    Reshes, G.; Vanounou, S.; Fishov, I.; Feingold, M.

    2008-12-01

    We monitor the shape dynamics of individual E. coli cells using time-lapse microscopy together with accurate image analysis. This allows measuring the dynamics of single-cell parameters throughout the cell cycle. In previous work, we have used this approach to characterize the main features of single-cell morphogenesis between successive divisions. Here, we focus on the behavior of the parameters that are related to cell division and study their variation over a population of 30 cells. In particular, we show that the single-cell data for the constriction width dynamics collapse onto a unique curve following appropriate rescaling of the corresponding variables. This suggests the presence of an underlying time scale that determines the rate at which the cell cycle advances in each individual cell. For the case of cell length dynamics a similar rescaling of variables emphasizes the presence of a breakpoint in the growth rate at the time when division starts, τc. We also find that the τc of individual cells is correlated with their generation time, τg, and inversely correlated with the corresponding length at birth, L0. Moreover, the extent of the T-period, τg - τc, is apparently independent of τg. The relations between τc, τg and L0 indicate possible compensation mechanisms that maintain cell length variability at about 10%. Similar behavior was observed for both fast-growing cells in a rich medium (LB) and for slower growth in a minimal medium (M9-glucose). To reveal the molecular mechanisms that lead to the observed organization of the cell cycle, we should further extend our approach to monitor the formation of the divisome.

  18. Wind damage to windows as estimated from explosion tests

    International Nuclear Information System (INIS)

    Reed, J.W.

    1973-01-01

    Window damage data from chemical and nuclear explosions were analyzed to provide information on the realistic behavior of installed glass. The results, in terms of blast overpressure, were transformed to wind gust loadings of comparable time scales, and can be used to predict window breakage probability for various wind speeds. (U.S.)

  19. Learning Windows Azure Mobile Services for Windows 8 and Windows Phone 8

    CERN Document Server

    Webber-Cross, Geoff

    2014-01-01

    This book is based around a case study game which was written for the book. This means that the chapters progress in a logical way and build upon lessons learned as we go. Real-world examples are provided for each topic that are practical and not given out-of-context so they can be applied directly to other applications.If you are a developer who wishes to build Windows 8 and Phone 8 applications and integrate them with Windows Azure Mobile Services, this book is for you. Basic C# and JavaScript skills are advantageous, as well as some knowledge of building Windows 8 or Windows Phone 8 applica

  20. Highly reconfigurable microwave photonic single-bandpass filter with complex continuous-time impulse responses.

    Science.gov (United States)

    Xue, Xiaoxiao; Zheng, Xiaoping; Zhang, Hanyi; Zhou, Bingkun

    2012-11-19

    We propose a novel structure of complex-tap microwave photonic filter (MPF) employing an incoherent broadband optical source (BOS) and a programmable optical spectrum processor. By tailoring the optical spectral amplitude and phase, arbitrary complex continuous-time impulse responses of the MPF can be constructed. Frequency responses with a single flat-top, highly chirped, or arbitrary-shape passband are demonstrated, respectively. The passband center can also be tuned in a wide range only limited by the opto-electrical devices. To the best of our knowledge, it is the first demonstration of an incoherent-BOS-based MPF which is single-bandpass, widely tunable, and highly reconfigurable with complex taps.

  1. Modeling Windows in Energy Plus with Simple Performance Indices

    Energy Technology Data Exchange (ETDEWEB)

    Arasteh, Dariush; Kohler, Christian; Griffith, Brent

    2009-10-12

    The building energy simulation program, Energy Plus (E+), cannot use standard window performance indices (U, SHGC, VT) to model window energy impacts. Rather, E+ uses more accurate methods which require a physical description of the window. E+ needs to be able to accept U and SHGC indices as window descriptors because, often, these are all that is known about a window and because building codes, standards, and voluntary programs are developed using these terms. This paper outlines a procedure, developed for E+, which will allow it to use standard window performance indices to model window energy impacts. In this 'Block' model, a given U, SHGC, VT are mapped to the properties of a fictitious 'layer' in E+. For thermal conductance calculations, the 'Block' functions as a single solid layer. For solar optical calculations, the model begins by defining a solar transmittance (Ts) at normal incidence based on the SHGC. For properties at non-normal incidence angles, the 'Block' takes on the angular properties of multiple glazing layers; the number and type of layers defined by the U and SHGC. While this procedure is specific to E+, parts of it may have applicability to other window/building simulation programs.

  2. Comprehensive GMO detection using real-time PCR array: single-laboratory validation.

    Science.gov (United States)

    Mano, Junichi; Harada, Mioko; Takabatake, Reona; Furui, Satoshi; Kitta, Kazumi; Nakamura, Kosuke; Akiyama, Hiroshi; Teshima, Reiko; Noritake, Hiromichi; Hatano, Shuko; Futo, Satoshi; Minegishi, Yasutaka; Iizuka, Tayoshi

    2012-01-01

    We have developed a real-time PCR array method to comprehensively detect genetically modified (GM) organisms. In the method, genomic DNA extracted from an agricultural product is analyzed using various qualitative real-time PCR assays on a 96-well PCR plate, targeting for individual GM events, recombinant DNA (r-DNA) segments, taxon-specific DNAs, and donor organisms of the respective r-DNAs. In this article, we report the single-laboratory validation of both DNA extraction methods and component PCR assays constituting the real-time PCR array. We selected some DNA extraction methods for specified plant matrixes, i.e., maize flour, soybean flour, and ground canola seeds, then evaluated the DNA quantity, DNA fragmentation, and PCR inhibition of the resultant DNA extracts. For the component PCR assays, we evaluated the specificity and LOD. All DNA extraction methods and component PCR assays satisfied the criteria set on the basis of previous reports.

  3. Method for single-shot measurement of picosecond laser pulse-lengths without electronic time dispersion

    International Nuclear Information System (INIS)

    Kyrala, G.A.

    1987-01-01

    A two-source shear pattern recording is proposed as a method for single-shot measurement of the pulse shape from nearly monochromatic sources whose pulse lengths are shorter than their coherence times. The basis of this method relies on the assertion that if two identical electromagnetic pulses are recombined with a time delay greater than the sum of their pulse widths, the recordable spatial pattern has no fringes in it. At an arbitrary delay, translated into an actual spatial recording position, the recorded modulated intensity will sample the corresponding laser intensity at that delay time, but with a modulation due to the coherence function of the electromagnetic pulse. Two arrangements are proposed for recording the pattern. The principles, the design parameters, and the methodologies of these arrangements are presented. Resolutions of the configurations and their limitations are given as well

  4. Window prototypes during the project

    DEFF Research Database (Denmark)

    Schultz, Jørgen Munthe

    1996-01-01

    The conditions for the PASSYS test and the results of the measurements on one of the aerogel window prototypes are described.......The conditions for the PASSYS test and the results of the measurements on one of the aerogel window prototypes are described....

  5. Thermal bridges of modern windows

    DEFF Research Database (Denmark)

    Hansen, Ernst Jan de Place; Møller, Eva B.; Nielsen, Anker

    2013-01-01

    With its focus on reduced energy consumption, contemporary housing construction requires a highly insulated and airtight building envelope with as few thermal bridges as possible.Windows must be carefully designed, as thermal bridges can lead to surface condensation or mold growth, even if the wi......With its focus on reduced energy consumption, contemporary housing construction requires a highly insulated and airtight building envelope with as few thermal bridges as possible.Windows must be carefully designed, as thermal bridges can lead to surface condensation or mold growth, even...... if the window has an U-factor of 1 W/(m2·K) or lower. This paper describes the development of modern, energy efficient Danish windows with reduced thermal bridges. It focuses on materials, geometry, and sealing of window panes based on a literature review. Examples of modern windows are presented. Experience...... been an important driver for the development of new window solutions in Denmark, increasing the inner-surface temperature at the sealing of window panes. However, it will not stop complaints fromconsumers, as this temperature is calculated under standardized conditions. Increasing requirements...

  6. Improved Windows for Cold Climates

    DEFF Research Database (Denmark)

    Laustsen, Jacob Birck; Svendsen, Svend

    2005-01-01

    considerably by reducing the frame width, which results in a larger transparent area causing a larger solar gain but still main-taining a low thermal transmittance. Using three layers of glass with large gaps, using very slim frame profiles, and omitting the edge constructions that normally causes thermal...... windows with improved energy performance. Traditionally evaluation of the energy performance of windows has focused on the thermal transmittance, but as windows differ from the rest of the building envelope by allowing solar energy to enter the building, the total solar energy transmittance is equally...... important. In the heating season in cold climates the solar gain through windows can be utilized for space heating which results in a corresponding reduction in the energy production that is often based on fossil fuels. A suitable quantity for evaluating the energy performance of windows in a simple...

  7. Windows for tablets for dummies

    CERN Document Server

    Rathbone, Andy

    2013-01-01

    Just for you--Windows 8 from the tablet user's perspective If you're an experienced Windows user, you don't need a guide to everything that Windows 8 can do, just to those tools and functions that work on your tablet. And so here it is. This new book zeros in on what you need to know to work best on your tablet with Windows 8. Topics include navigating the new Windows 8 interface and how it works on a touchscreen, how to safely connect to the Internet, how to work with apps or share your tablet in a group, and much more. If you're a new tablet user, you'll particularly appre

  8. Handbook on Windows and Energy

    DEFF Research Database (Denmark)

    Thomsen, Kirsten Engelund; Schultz, Jørgen Munthe; Svendsen, Sv Aa Højgaard

    transmission through windows is described in detail including radiation, convection and conduction as well as solar transmittance of window glazing. The most used terms related to characterization of window energy performance are defined and calculation methods according to international standards...... flow and detailed calculation of light and solar transmittance is given.Different measurement techniques for characterization of window heat loss coefficient and total solar energy transmittance is described and references to interantional standards are given.Finally, the handbook includes...... a comprehensive list of window related standards and a list of Nordic research and development projects.Two programs are encloased in the handbook for calculation of solar radiation on inclined surfaces including a shadow correction and a simple program for evaluation of energy savings and risk of overtemperature....

  9. 32-channel time-correlated-single-photon-counting system for high-throughput lifetime imaging.

    Science.gov (United States)

    Peronio, P; Labanca, I; Acconcia, G; Ruggeri, A; Lavdas, A A; Hicks, A A; Pramstaller, P P; Ghioni, M; Rech, I

    2017-08-01

    Time-Correlated Single Photon Counting (TCSPC) is a very efficient technique for measuring weak and fast optical signals, but it is mainly limited by the relatively "long" measurement time. Multichannel systems have been developed in recent years aiming to overcome this limitation by managing several detectors or TCSPC devices in parallel. Nevertheless, if we look at state-of-the-art systems, there is still a strong trade-off between the parallelism level and performance: the higher the number of channels, the poorer the performance. In 2013, we presented a complete and compact 32 × 1 TCSPC system, composed of an array of 32 single-photon avalanche diodes connected to 32 time-to-amplitude converters, which showed that it was possible to overcome the existing trade-off. In this paper, we present an evolution of the previous work that is conceived for high-throughput fluorescence lifetime imaging microscopy. This application can be addressed by the new system thanks to a centralized logic, fast data management and an interface to a microscope. The new conceived hardware structure is presented, as well as the firmware developed to manage the operation of the module. Finally, preliminary results, obtained from the practical application of the technology, are shown to validate the developed system.

  10. 32-channel time-correlated-single-photon-counting system for high-throughput lifetime imaging

    Science.gov (United States)

    Peronio, P.; Labanca, I.; Acconcia, G.; Ruggeri, A.; Lavdas, A. A.; Hicks, A. A.; Pramstaller, P. P.; Ghioni, M.; Rech, I.

    2017-08-01

    Time-Correlated Single Photon Counting (TCSPC) is a very efficient technique for measuring weak and fast optical signals, but it is mainly limited by the relatively "long" measurement time. Multichannel systems have been developed in recent years aiming to overcome this limitation by managing several detectors or TCSPC devices in parallel. Nevertheless, if we look at state-of-the-art systems, there is still a strong trade-off between the parallelism level and performance: the higher the number of channels, the poorer the performance. In 2013, we presented a complete and compact 32 × 1 TCSPC system, composed of an array of 32 single-photon avalanche diodes connected to 32 time-to-amplitude converters, which showed that it was possible to overcome the existing trade-off. In this paper, we present an evolution of the previous work that is conceived for high-throughput fluorescence lifetime imaging microscopy. This application can be addressed by the new system thanks to a centralized logic, fast data management and an interface to a microscope. The new conceived hardware structure is presented, as well as the firmware developed to manage the operation of the module. Finally, preliminary results, obtained from the practical application of the technology, are shown to validate the developed system.

  11. Real-time MPEG video codec on a single-chip multiprocessor

    Science.gov (United States)

    Lee, Woobin; Golston, Jeremiah; Gove, Robert J.; Kim, Yongmin

    1994-05-01

    We present a software implementation of a real-time MPEG video codec on the MediaStation 5000 multimedia system. Unlike other compression systems whose sole function is the encoding or decoding of video data, the MediaStation 5000 is capable of performing various real-time operations involving a wide range of multimedia data, including image, graphics, video, and even audio. This programmability is provided by Texas Instruments TMS320C80, better known as Multimedia Video Processor (MVP), which is a single-chip multiprocessing device with highly parallel internal architecture. The MVP integrates a RISC processor, four DSP-like processors, an intelligent DMA controller, video controllers, and a large amount of SRAMs onto a single chip. Since the MVP contains such a high degree of parallel features, developing the MPEG software and mapping it to the MVP requires a thorough study of the algorithms and a good understanding of the processor architecture. By exploiting the advanced features of the MVP, the MediaStation 5000 can achieve the MPEG compression and decompression of video sequences in real time.

  12. ROS wrapper for real-time multi-person pose estimation with a single camera

    OpenAIRE

    Arduengo García, Miguel; Jorgensen, Steven Jens; Hambuchen, Kimberly; Sentis, Luis; Moreno-Noguer, Francesc; Alenyà Ribas, Guillem

    2017-01-01

    For robots to be deployable in human occupied environments, the robots must have human-awareness and generate human-aware behaviors and policies. OpenPose is a library for real-time multi-person keypoint detection. We have considered the implementation of a ROS package that would allow the estimation of 2d pose from simple RGB images, for which we have introduced a ROS wrapper that automatically recovers the pose of several people from a single camera using OpenPose. Additionally, a ROS node ...

  13. Integration of neutron time-of-flight single-crystal Bragg peaks in reciprocal space

    Energy Technology Data Exchange (ETDEWEB)

    Schultz, Arthur J [ORNL; Joergensen, Mads [ORNL; Wang, Xiaoping [ORNL; Mikkelson, Ruth L [ORNL; Mikkelson, Dennis J [ORNL; Lynch, Vickie E [ORNL; Peterson, Peter F [ORNL; Green, Mark L [ORNL; Hoffmann, Christina [ORNL

    2014-01-01

    The intensity of single crystal Bragg peaks obtained by mapping neutron time-of-flight event data into reciprocal space and integrating in various ways are compared. These include spherical integration with a fixed radius, ellipsoid fitting and integrating of the peak intensity and one-dimensional peak profile fitting. In comparison to intensities obtained by integrating in real detector histogram space, the data integrated in reciprocal space results in better agreement factors and more accurate atomic parameters. Furthermore, structure refinement using integrated intensities from one-dimensional profile fitting is demonstrated to be more accurate than simple peak-minus-background integration.

  14. Profiling of Oral Microbiota in Early Childhood Caries Using Single-Molecule Real-Time Sequencing

    OpenAIRE

    Yuan Wang; Jie Zhang; Xi Chen; Wen Jiang; Sa Wang; Lei Xu; Yan Tu; Pei Zheng; Ying Wang; Xiaolong Lin; Hui Chen

    2017-01-01

    Background: Alterations of oral microbiota are the main cause of the progression of caries. The goal of this study was to characterize the oral microbiota in childhood caries based on single-molecule real-time sequencing.Methods: A total of 21 preschoolers, aged 3–5 years old with severe early childhood caries, and 20 age-matched, caries-free children as controls were recruited. Saliva samples were collected, followed by DNA extraction, Pacbio sequencing, and phylogenetic analyses of the oral...

  15. Single photon timing resolution and detection efficiency of the IRST silicon photo-multipliers

    International Nuclear Information System (INIS)

    Collazuol, G.; Ambrosi, G.; Boscardin, M.; Corsi, F.; Dalla Betta, G.F.; Del Guerra, A.; Dinu, N.; Galimberti, M.; Giulietti, D.; Gizzi, L.A.; Labate, L.; Llosa, G.; Marcatili, S.; Morsani, F.; Piemonte, C.; Pozza, A.; Zaccarelli, L.; Zorzi, N.

    2007-01-01

    Silicon photo-multipliers (SiPM) consist in matrices of tiny, passive quenched avalanche photo-diode cells connected in parallel via integrated resistors and operated in Geiger mode. Novel types of SiPM are being developed at FBK-IRST (Trento, Italy). Despite their classical shallow junction n-on-p structure the devices are unique in their enhanced photo-detection efficiency (PDE) for short-wavelengths and in their low level of dark rate and excess noise factor. After a summary of the extensive SiPM characterization we will focus on the study of PDE and the single photon timing resolution

  16. Two-Player Reachability-Price Games on Single-Clock Timed Automata

    Directory of Open Access Journals (Sweden)

    Michal Rutkowski

    2011-07-01

    Full Text Available We study two player reachability-price games on single-clock timed automata. The problem is as follows: given a state of the automaton, determine whether the first player can guarantee reaching one of the designated goal locations. If a goal location can be reached then we also want to compute the optimum price of doing so. Our contribution is twofold. First, we develop a theory of cost functions, which provide a comprehensive methodology for the analysis of this problem. This theory allows us to establish our second contribution, an EXPTIME algorithm for computing the optimum reachability price, which improves the existing 3EXPTIME upper bound.

  17. Timing Solution and Single-pulse Properties for Eight Rotating Radio Transients

    Energy Technology Data Exchange (ETDEWEB)

    Cui, B.-Y.; McLaughlin, M. A. [Department of Physics and Astronomy West Virginia University Morgantown, WV 26506 (United States); Boyles, J. [Department of Physics and Astronomy West Kentucky University Bowling Green, KY 42101 (United States); Palliyaguru, N. [Physics and Astronomy Department Texas Tech University Lubbock, TX 79409-1051 (United States)

    2017-05-01

    Rotating radio transients (RRATs), loosely defined as objects that are discovered through only their single pulses, are sporadic pulsars that have a wide range of emission properties. For many of them, we must measure their periods and determine timing solutions relying on the timing of their individual pulses, while some of the less sporadic RRATs can be timed by using folding techniques as we do for other pulsars. Here, based on Parkes and Green Bank Telescope (GBT) observations, we introduce our results on eight RRATs including their timing-derived rotation parameters, positions, and dispersion measures (DMs), along with a comparison of the spin-down properties of RRATs and normal pulsars. Using data for 24 RRATs, we find that their period derivatives are generally larger than those of normal pulsars, independent of any intrinsic correlation with period, indicating that RRATs’ highly sporadic emission may be associated with intrinsically larger magnetic fields. We carry out Lomb–Scargle tests to search for periodicities in RRATs’ pulse detection times with long timescales. Periodicities are detected for all targets, with significant candidates of roughly 3.4 hr for PSR J1623−0841 and 0.7 hr for PSR J1839−0141. We also analyze their single-pulse amplitude distributions, finding that log-normal distributions provide the best fits, as is the case for most pulsars. However, several RRATs exhibit power-law tails, as seen for pulsars emitting giant pulses. This, along with consideration of the selection effects against the detection of weak pulses, imply that RRAT pulses generally represent the tail of a normal intensity distribution.

  18. Timing Solution and Single-pulse Properties for Eight Rotating Radio Transients

    Science.gov (United States)

    Cui, B.-Y.; Boyles, J.; McLaughlin, M. A.; Palliyaguru, N.

    2017-05-01

    Rotating radio transients (RRATs), loosely defined as objects that are discovered through only their single pulses, are sporadic pulsars that have a wide range of emission properties. For many of them, we must measure their periods and determine timing solutions relying on the timing of their individual pulses, while some of the less sporadic RRATs can be timed by using folding techniques as we do for other pulsars. Here, based on Parkes and Green Bank Telescope (GBT) observations, we introduce our results on eight RRATs including their timing-derived rotation parameters, positions, and dispersion measures (DMs), along with a comparison of the spin-down properties of RRATs and normal pulsars. Using data for 24 RRATs, we find that their period derivatives are generally larger than those of normal pulsars, independent of any intrinsic correlation with period, indicating that RRATs’ highly sporadic emission may be associated with intrinsically larger magnetic fields. We carry out Lomb-Scargle tests to search for periodicities in RRATs’ pulse detection times with long timescales. Periodicities are detected for all targets, with significant candidates of roughly 3.4 hr for PSR J1623-0841 and 0.7 hr for PSR J1839-0141. We also analyze their single-pulse amplitude distributions, finding that log-normal distributions provide the best fits, as is the case for most pulsars. However, several RRATs exhibit power-law tails, as seen for pulsars emitting giant pulses. This, along with consideration of the selection effects against the detection of weak pulses, imply that RRAT pulses generally represent the tail of a normal intensity distribution.

  19. Single-shot echo-planar imaging of multiple sclerosis: effects of varying echo time

    International Nuclear Information System (INIS)

    Wolansky, L.J.; Chong, S.; Liu, W.C.; Kang, E.; Simpson, S.W.; Karimi, S.; Akbari, H.

    1999-01-01

    Our aim was to determine the relative merits of short and long echo times (TE) with single-shot echo-planar imaging for imaging cerebral lesions such as multiple sclerosis. We examined seven patients with clinically definite multiple sclerosis were imaged at 1.5 T. Patients were scanned with spin-echo, single-shot echo-planar imaging, using TEs of 45, 75, 105, and 135 ms. Region of interest (ROI) measurements were performed on 36 lesions at or above the level of the corona radiata. The mean image contrast (IC) was highest (231.1) for a TE of 45 ms, followed by 75 ms (218.9), 105 ms (217.9), and 135 ms (191.6). When mean contrast-to-noise ratios (C/N) were compared, the value was again highest (29.7) for TE 45 ms, followed by 75 ms (28.9), 105 ms (28.5), and 135 ms (26.3). In a lesion-by-lesion comparison, TE 45 ms had the highest IC and C/N in the largest number of cases (50 % and 47.2 %, respectively). IC and C/N for TE 45 ms were superior to those of 75 ms in 64 % and 58 %, respectively. These results support the use of relatively short TEs for single-shot echo-planar imaging in the setting of cerebral lesions such as multiple sclerosis. (orig.) (orig.)

  20. [The principle and application of the single-molecule real-time sequencing technology].

    Science.gov (United States)

    Yanhu, Liu; Lu, Wang; Li, Yu

    2015-03-01

    Last decade witnessed the explosive development of the third-generation sequencing strategy, including single-molecule real-time sequencing (SMRT), true single-molecule sequencing (tSMSTM) and the single-molecule nanopore DNA sequencing. In this review, we summarize the principle, performance and application of the SMRT sequencing technology. Compared with the traditional Sanger method and the next-generation sequencing (NGS) technologies, the SMRT approach has several advantages, including long read length, high speed, PCR-free and the capability of direct detection of epigenetic modifications. However, the disadvantage of its low accuracy, most of which resulted from insertions and deletions, is also notable. So, the raw sequence data need to be corrected before assembly. Up to now, the SMRT is a good fit for applications in the de novo genomic sequencing and the high-quality assemblies of small genomes. In the future, it is expected to play an important role in epigenetics, transcriptomic sequencing, and assemblies of large genomes.

  1. SENJU: a new time-of-flight single-crystal neutron diffractometer at J-PARC.

    Science.gov (United States)

    Ohhara, Takashi; Kiyanagi, Ryoji; Oikawa, Kenichi; Kaneko, Koji; Kawasaki, Takuro; Tamura, Itaru; Nakao, Akiko; Hanashima, Takayasu; Munakata, Koji; Moyoshi, Taketo; Kuroda, Tetsuya; Kimura, Hiroyuki; Sakakura, Terutoshi; Lee, Chang-Hee; Takahashi, Miwako; Ohshima, Ken-Ichi; Kiyotani, Tamiko; Noda, Yukio; Arai, Masatoshi

    2016-02-01

    SENJU is a new single-crystal time-of-flight neutron diffractometer installed at BL18 at the Materials and Life Science Experimental Facility of the Japan Accelerator Research Complex (J-PARC). The diffractometer was designed for precise crystal and magnetic structure analyses under multiple extreme sample environments such as low temperature, high pressure and high magnetic field, and for diffraction measurements of small single crystals down to 0.1 mm 3 in volume. SENJU comprises three choppers, an elliptical shape straight supermirror guide, a vacuum sample chamber and 37 scintillator area detectors. The moderator-to-sample distance is 34.8 m, and the sample-to-detector distance is 800 mm. The wavelength of incident neutrons is 0.4-4.4 Å (first frame). Because short-wavelength neutrons are available and the large solid angle around the sample position is covered by the area detectors, a large reciprocal space can be simultaneously measured. Furthermore, the vacuum sample chamber and collimator have been designed to produce a very low background level. Thus, the measurement of a small single crystal is possible. As sample environment devices, a newly developed cryostat with a two-axis (ω and φ axes) goniometer and some extreme environment devices, e.g. a vertical-field magnet, high-temperature furnace and high-pressure cell, are available. The structure analysis of a sub-millimetre size (0.1 mm 3 ) single organic crystal, taurine, and a magnetic structure analysis of the antiferromagnetic phase of MnF 2 have been performed. These results demonstrate that SENJU can be a powerful tool to promote materials science research.

  2. Managing customer arrivals with time windows

    DEFF Research Database (Denmark)

    Chen, Gang; Jiang, Liping

    2016-01-01

    Due to increasing container traffic and mega-ships, many seaports face challenges of huge amounts of truck arrivals and congestion problem at terminal gates, which affect port efficiency and generate serious air pollution. To solve this congestion problem, we propose a solution of managing truck...... are conducted based on real data. The result shows that (1) good planning coordination is essential for the proposed method; and (2) FEP is found to be a better strategy than the other two....

  3. Recalculation of the unitary single planar dual loop in the critical dimension of space time

    CERN Document Server

    Brink, L

    1973-01-01

    The single planar dual-loop amplitudes are recalculated in the critical dimension of space time paying particular attention to the unitarity property by ensuring that the only states propagating internally in the loop are those needed to factorize tree diagram residues in a positive definite way. The two new technical features which make this possible are (i) a newly discovered physical state projection operator valid if the space- time dimension takes the critical value; (ii) the use of Feynman's tree theorem whereby it is sufficient to have the above projection operator on the mass shell. The final result agrees with a previous conjecture in that it differs from the original calculations with unprojected propagators by two inverse power of a certain partition function. The results apply to both the ordinary dual model and the Neveu-Schwarz model. (12 refs).

  4. Reward-timing-dependent bidirectional modulation of cortical microcircuits during optical single-neuron operant conditioning.

    Science.gov (United States)

    Hira, Riichiro; Ohkubo, Fuki; Masamizu, Yoshito; Ohkura, Masamichi; Nakai, Junichi; Okada, Takashi; Matsuzaki, Masanori

    2014-11-24

    Animals rapidly adapt to environmental change. To reveal how cortical microcircuits are rapidly reorganized when an animal recognizes novel reward contingency, we conduct two-photon calcium imaging of layer 2/3 motor cortex neurons in mice and simultaneously reinforce the activity of a single cortical neuron with water delivery. Here we show that when the target neuron is not relevant to a pre-trained forelimb movement, the mouse increases the target neuron activity and the number of rewards delivered during 15-min operant conditioning without changing forelimb movement behaviour. The reinforcement bidirectionally modulates the activity of subsets of non-target neurons, independent of distance from the target neuron. The bidirectional modulation depends on the relative timing between the reward delivery and the neuronal activity, and is recreated by pairing reward delivery and photoactivation of a subset of neurons. Reward-timing-dependent bidirectional modulation may be one of the fundamental processes in microcircuit reorganization for rapid adaptation.

  5. Single-pixel three-dimensional imaging with time-based depth resolution

    Science.gov (United States)

    Sun, Ming-Jie; Edgar, Matthew P.; Gibson, Graham M.; Sun, Baoqing; Radwell, Neal; Lamb, Robert; Padgett, Miles J.

    2016-07-01

    Time-of-flight three-dimensional imaging is an important tool for applications such as object recognition and remote sensing. Conventional time-of-flight three-dimensional imaging systems frequently use a raster scanned laser to measure the range of each pixel in the scene sequentially. Here we show a modified time-of-flight three-dimensional imaging system, which can use compressed sensing techniques to reduce acquisition times, whilst distributing the optical illumination over the full field of view. Our system is based on a single-pixel camera using short-pulsed structured illumination and a high-speed photodiode, and is capable of reconstructing 128 × 128-pixel resolution three-dimensional scenes to an accuracy of ~3 mm at a range of ~5 m. Furthermore, by using a compressive sampling strategy, we demonstrate continuous real-time three-dimensional video with a frame-rate up to 12 Hz. The simplicity of the system hardware could enable low-cost three-dimensional imaging devices for precision ranging at wavelengths beyond the visible spectrum.

  6. Single Machine Problem with Multi-Rate-Modifying Activities under a Time-Dependent Deterioration

    Directory of Open Access Journals (Sweden)

    M. Huang

    2013-01-01

    Full Text Available The single machine scheduling problem with multi-rate-modifying activities under a time-dependent deterioration to minimize makespan is studied. After examining the characteristics of the problem, a number of properties and a lower bound are proposed. A branch and bound algorithm and a heuristic algorithm are used in the solution, and two special cases are also examined. The computational experiments show that, for the situation with a rate-modifying activity, the proposed branch and bound algorithm can solve situations with 50 jobs within a reasonable time, and the heuristic algorithm can obtain the near-optimal solution with an error percentage less than 0.053 in a very short time. In situations with multi-rate-modifying activities, the proposed branch and bound algorithm can solve the case with 15 jobs within a reasonable time, and the heuristic algorithm can obtain the near-optimal with an error percentage less than 0.070 in a very short time. The branch and bound algorithm and the heuristic algorithm are both shown to be efficient and effective.

  7. The giant acoustic atom - a single quantum system with a deterministic time delay

    Science.gov (United States)

    Guo, Lingzhen; Grimsmo, Arne; Frisk Kockum, Anton; Pletyukhov, Mikhail; Johansson, Göran

    2017-04-01

    We investigate the quantum dynamics of a single transmon qubit coupled to surface acoustic waves (SAWs) via two distant connection points. Since the acoustic speed is five orders of magnitude slower than the speed of light, the travelling time between the two connection points needs to be taken into account. Therefore, we treat the transmon qubit as a giant atom with a deterministic time delay. We find that the spontaneous emission of the system, formed by the giant atom and the SAWs between its connection points, initially follows a polynomial decay law instead of an exponential one, as would be the case for a small atom. We obtain exact analytical results for the scattering properties of the giant atom up to two-phonon processes by using a diagrammatic approach. The time delay gives rise to novel features in the reflection, transmission, power spectra, and second-order correlation functions of the system. Furthermore, we find the short-time dynamics of the giant atom for arbitrary drive strength by a numerically exact method for open quantum systems with a finite-time-delay feedback loop. L. G. acknowledges financial support from Carl-Zeiss Stiftung (0563-2.8/508/2).

  8. Time-correlated single-photon counting study of multiple photoluminescence lifetime components of silicon nanoclusters

    Energy Technology Data Exchange (ETDEWEB)

    Diamare, D., E-mail: d.diamare@ee.ucl.ac.uk [Department of Electronic and Electrical Engineering, University College London, Torrington Place, London, WC1E 7JE (United Kingdom); Wojdak, M. [Department of Electronic and Electrical Engineering, University College London, Torrington Place, London, WC1E 7JE (United Kingdom); Lettieri, S. [Institute for Superconductors and Innovative Materials, National Council of Research (CNR-SPIN), Via Cintia 80126, Naples (Italy); Department of Physical Sciences, University of Naples “Federico II”, Via Cintia 80126, Naples (Italy); Kenyon, A.J. [Department of Electronic and Electrical Engineering, University College London, Torrington Place, London, WC1E 7JE (United Kingdom)

    2013-04-15

    We report time-resolved photoluminescence measurements of thin films of silica containing silicon nanoclusters (Si NCs), produced by PECVD and annealed at temperatures between 700 °C and 1150 °C. While the near infrared emission of Si NCs has long been studied, visible light emission has only recently attracted interest due to its very short decay times and its recently-reported redshift with decreasing NCs size. We analyse the PL decay dynamics in the range 450–700 nm with picosecond time resolution using Time Correlated Single Photon Counting. In the resultant multi-exponential decays two dominant components can clearly be distinguished: a very short component, in the range of hundreds of picoseconds, and a nanosecond component. In this wavelength range we do not detect the microsecond component generally associated with excitonic recombination. We associate the nanosecond component to defect relaxation: it decreases in intensity in the sample annealed at higher temperature, suggesting that the contribution from defects decreases with increasing temperature. The origin of the very fast PL component (ps time region) is also discussed. We show that it is consistent with the Auger recombination times of multiple excitons. Further work needs to be done in order to assess the contribution of the Auger-controlled recombinations to the defect-assisted mechanism of photoluminescence. -- Highlights: ► We report time-resolved PL measurements of Si-Ncs embedded in SiO{sub 2} matrix. ► Net decrease of PL with increasing the annealing temperature has been observed. ► Lifetime distribution analysis revealed a multiexponential decay with ns and ps components. ► Ps components are consistent with the lifetime range of the Auger recombination times. ► No evidence for a fast direct transition at the Brillouin zone centre.

  9. New real-time heartbeat detection method using the angle of a single-lead electrocardiogram.

    Science.gov (United States)

    Song, Mi-Hye; Cho, Sung-Pil; Kim, Wonky; Lee, Kyoung-Joung

    2015-04-01

    This study presents a new real-time heartbeat detection algorithm using the geometric angle between two consecutive samples of single-lead electrocardiogram (ECG) signals. The angle was adopted as a new index representing the slope of ECG signal. The method consists of three steps: elimination of high-frequency noise, calculation of the angle of ECG signal, and detection of R-waves using a simple adaptive thresholding technique. The MIT-BIH arrhythmia database, QT database, European ST-T database, T-wave alternans database and synthesized ECG signals were used to evaluate the performance of the proposed algorithm and compare with the results of other methods suggested in literature. The proposed method shows a high detection rate-99.95% of the sensitivity, 99.95% of the positive predictivity, and 0.10% of the fail detection rate on the four databases. The result shows that the proposed method can yield better or comparable performance than other literature despite the relatively simple process. The proposed algorithm needs only a single-lead ECG, and involves a simple and quick calculation. Moreover, it does not require post-processing to enhance the detection. Thus, it can be effectively applied to various real-time healthcare and medical devices. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. Single trap in liquid gated nanowire FETs: Capture time behavior as a function of current

    Science.gov (United States)

    Gasparyan, F.; Zadorozhnyi, I.; Vitusevich, S.

    2015-05-01

    The basic reason for enhanced electron capture time, τ c , of the oxide single trap dependence on drain current in the linear operation regime of p+-p-p+ silicon field effect transistors (FETs) was established, using a quantum-mechanical approach. A strong increase of τ c slope dependence on channel current is explained using quantization and tunneling concepts in terms of strong field dependence of the oxide layer single trap effective cross-section, which can be described by an amplification factor. Physical interpretation of this parameter deals with the amplification of the electron cross-section determined by both decreasing the critical field influence as a result of the minority carrier depletion and the potential barrier growth for electron capture. For the NW channel of n+-p-n+ FETs, the experimentally observed slope of τ c equals (-1). On the contrary, for the case of p+-p-p+ Si FETs in the accumulation regime, the experimentally observed slope of τ c equals (-2.8). It can be achieved when the amplification factor is about 12. Extraordinary high capture time slope values versus current are explained by the effective capture cross-section growth with decreasing electron concentration close to the nanowire-oxide interface.

  11. Real-time, profile-corrected single snapshot imaging of optical properties

    Science.gov (United States)

    van de Giessen, Martijn; Angelo, Joseph P.; Gioux, Sylvain

    2015-01-01

    A novel acquisition and processing method that enables real-time, single snapshot of optical properties (SSOP) and 3-dimensional (3D) profile measurements in the spatial frequency domain is described. This method makes use of a dual sinusoidal wave projection pattern permitting to extract the DC and AC components in the frequency domain to recover optical properties as well as the phase for measuring the 3D profile. In this method, the 3D profile is used to correct for the effect of sample’s height and angle and directly obtain profile-corrected absorption and reduced scattering maps from a single acquired image. In this manuscript, the 3D-SSOP method is described and validated on tissue-mimicking phantoms as well as in vivo, in comparison with the standard profile-corrected SFDI (3D-SFDI) method. On average, in comparison with 3D-SFDI method, the 3D-SSOP method allows to recover the profile within 1.2mm and profile-corrected optical properties within 12% for absorption and 6% for reduced scattering over a large field-of-view and in real-time. PMID:26504653

  12. Real-time observation of conformational switching in single conjugated polymer chains.

    Science.gov (United States)

    Tenopala-Carmona, Francisco; Fronk, Stephanie; Bazan, Guillermo C; Samuel, Ifor D W; Penedo, J Carlos

    2018-02-01

    Conjugated polymers (CPs) are an important class of organic semiconductors that combine novel optoelectronic properties with simple processing from organic solvents. It is important to study CP conformation in solution to understand the physics of these materials and because it affects the properties of solution-processed films. Single-molecule techniques are unique in their ability to extract information on a chain-to-chain basis; however, in the context of CPs, technical challenges have limited their general application to host matrices or semiliquid environments that constrain the conformational dynamics of the polymer. We introduce a conceptually different methodology that enables measurements in organic solvents using the single-end anchoring of polymer chains to avoid diffusion while preserving polymer flexibility. We explore the effect of organic solvents and show that, in addition to chain-to-chain conformational heterogeneity, collapsed and extended polymer segments can coexist within the same chain. The technique enables real-time solvent-exchange measurements, which show that anchored CP chains respond to sudden changes in solvent conditions on a subsecond time scale. Our results give an unprecedented glimpse into the mechanism of solvent-induced reorganization of CPs and can be expected to lead to a new range of techniques to investigate and conformationally manipulate CPs.

  13. High-Reliability Waveguide Vacuum/Pressure Window

    Science.gov (United States)

    Britcliffe, Michael J.; Hanson, Theodore R.; Long, Ezra M.; Montanez, Steven

    2013-01-01

    The NASA Deep Space Network (DSN) uses commercial waveguide windows on the output waveguide of Ka-band (32 GHz) low-noise amplifiers. Mechanical failure of these windows resulted in an unacceptable loss in tracking time. To address this issue, a new Ka-band WR-28 waveguide window has been designed, fabricated, and tested. The window uses a slab of low-loss, low-dielectric constant foam that is bonded into a 1/2-wave-thick waveguide/flange. The foam is a commercially available, rigid, closed-cell polymethacrylimide. It has excellent electrical properties with a dielectric constant of 1.04, and a loss tangent of 0.01. It is relatively strong with a tensile strength of 1 MPa. The material is virtually impermeable to helium. The finished window exhibits a leak rate of less than 3x10(exp -3)cu cm/s with helium. The material is also chemically resistant and can be cleaned with acetone. The window is constructed by fabricating a window body by brazing a short length of WR-28 copper waveguide into a standard rectangular flange, and machining the resulting part to a thickness of 4.6 mm. The foam is machined to a rectangular shape with a dimension of 7.06x3.53 mm. The foam is bonded into the body with a two-part epoxy. After curing, the excess glue and foam are knife-trimmed by hand. The finished window has a loss of less than 0.08 dB (2%) and a return loss of greater than 25 dB at 32 GHz. This meets the requirements for the DSN application. The window is usable for most applications over the entire 26-to-40-GHz waveguide band. The window return loss can be tuned to a required frequency by var y in g the thickness of the window slightly. Most standard waveguide windows use a thin membrane of material bonded into a recess in a waveguide flange, or sandwiched between two flanges with a polymer seal. Designs using the recessed window are prone to mechanical failure over time due to constraints on the dimensions of the recess that allow the bond to fail. Designs using the

  14. Windows 8 visual quick tips

    CERN Document Server

    McFedries, Paul

    2012-01-01

    Easy-in, easy-out format covers all the bells and whistles of Windows 8 If you want to learn how to work smarter and faster in Microsoft's Windows 8 operating system, this easy-to-use, compact guide delivers the goods. Designed for visual learners, it features short explanations and full-color screen shots on almost every page, and it's packed with timesaving tips and helpful productivity tricks. From enhancing performance and managing digital content to setting up security and much more, this handy guide will help you get more out of Windows 8. Uses full-color screen shots and short, step-by-

  15. Transparent solar cell window module

    Energy Technology Data Exchange (ETDEWEB)

    Chau, Joseph Lik Hang; Chen, Ruei-Tang; Hwang, Gan-Lin; Tsai, Ping-Yuan [Nanopowder and Thin Film Technology Center, ITRI South, Industrial Technology Research Institute, Tainan County 709 (China); Lin, Chien-Chu [I-Lai Acrylic Corporation, Tainan City (China)

    2010-03-15

    A transparent solar cell window module based on the integration of traditional silicon solar cells and organic-inorganic nanocomposite material was designed and fabricated. The transparent solar cell window module was composed of a nanocomposite light-guide plate and traditional silicon solar cells. The preparation of the nanocomposite light-guide plate is easy without modification of the traditional casting process, the nanoparticles sol can be added directly to the polymethyl methacrylate (PMMA) monomer syrup during the process. The solar energy collected by this window can be used to power up small household electrical appliances. (author)

  16. Big Book of Windows Hacks

    CERN Document Server

    Gralla, Preston

    2008-01-01

    Bigger, better, and broader in scope, the Big Book of Windows Hacks gives you everything you need to get the most out of your Windows Vista or XP system, including its related applications and the hardware it runs on or connects to. Whether you want to tweak Vista's Aero interface, build customized sidebar gadgets and run them from a USB key, or hack the "unhackable" screensavers, you'll find quick and ingenious ways to bend these recalcitrant operating systems to your will. The Big Book of Windows Hacks focuses on Vista, the new bad boy on Microsoft's block, with hacks and workarounds that

  17. Windows Phone 7 Made Simple

    CERN Document Server

    Trautschold, Martin

    2011-01-01

    With Windows Phone 7, Microsoft has created a completely new smartphone operating system that focuses on allowing users to be productive with their smartphone in new ways, while offering seamless integration and use of Microsoft Office Mobile as well as other productivity apps available in the Microsoft App Store. Windows Phone 7 Made Simple offers a clear, visual, step-by-step approach to using your Windows Phone 7 smartphone, no matter what the manufacturer. Author Jon Westfall is an expert in mobile devices, recognized by Microsoft as a "Most Valuable Professional" with experience

  18. Custom single-photon avalanche diode with integrated front-end for parallel photon timing applications

    Science.gov (United States)

    Cammi, C.; Panzeri, F.; Gulinatti, A.; Rech, I.; Ghioni, M.

    2012-03-01

    Emerged as a solid state alternative to photo multiplier tubes (PMTs), single-photon avalanche diodes (SPADs) are nowadays widely used in the field of single-photon timing applications. Custom technology SPADs assure remarkable performance, in particular a 10 counts/s dark count rate (DCR) at low temperature, a high photon detection efficiency (PDE) with a 50% peak at 550 nm and a 30 ps (full width at half maximum, FWHM) temporal resolution, even with large area devices, have been obtained. Over the past few years, the birth of novel techniques of analysis has led to the parallelization of the measurement systems and to a consequent increasing demand for the development of monolithic arrays of detectors. Unfortunately, the implementation of a multidimensional system is a challenging task from the electrical point of view; in particular, the avalanche current pick-up circuit, used to obtain the previously reported performance, has to be modified in order to enable high parallel temporal resolution, while minimizing the electrical crosstalk probability between channels. In the past, the problem has been solved by integrating the front-end electronics next to the photodetector, in order to reduce the parasitic capacitances and consequently the filtering action on the current signal of the SPAD, leading to an improvement of the timing jitter at higher threshold. This solution has been implemented by using standard complementary metal-oxide-semiconductor (CMOS) technologies, which, however, do not allow a complete control on the SPAD structure; for this reason the intrinsic performance of CMOS SPADs, such as DCR, PDE, and afterpulsing probability, are worse than those attainable with custom detectors. In this paper, we propose a pixel architecture, which enables the development of custom SPAD arrays in which every channel maintains the performance of the best single photodetector. The system relies on the integration of the timing signal pick-up circuit next to the

  19. Grab Windows training opportunities; check CERN Windows roadmap!

    CERN Multimedia

    IT Department

    2011-01-01

    CERN Operating Systems and Information Services group (IT-OIS) actively monitors market trends to check how new software products correspond to CERN needs. In the Windows world, Windows 7 has been a big hit, with over 1500 Windows 7 PCs within less than a year since its support was introduced at CERN. No wonder: Windows XP is nearly 10 years old and is steadily approaching the end of its life-cycle. At CERN, support for Windows XP will stop at the end of December 2012. Compared to Vista, Windows 7 has the same basic hardware requirements, but offers higher performance, so the decision to upgrade is rather straightforward. CERN support for Vista will end in June 2011. In the world of Microsoft Office, version 2007 offers better integration with the central services than the older version 2003. Progressive upgrade from 2003 to 2007 is planned to finish in September 2011, but users are encouraged to pro-actively upgrade at their convenience. Please note that Office 2007 brings an important change in the area of ...

  20. Window area and development drive spatial variation in bird-window collisions in an urban landscape.

    Science.gov (United States)

    Hager, Stephen B; Cosentino, Bradley J; McKay, Kelly J; Monson, Cathleen; Zuurdeeg, Walt; Blevins, Brian

    2013-01-01

    Collisions with windows are an important human-related threat to birds in urban landscapes. However, the proximate drivers of collisions are not well understood, and no study has examined spatial variation in mortality in an urban setting. We hypothesized that the number of fatalities at buildings varies with window area and habitat features that influence avian community structure. In 2010 we documented bird-window collisions (BWCs) and characterized avian community structure at 20 buildings in an urban landscape in northwestern Illinois, USA. For each building and season, we conducted 21 daily surveys for carcasses and nine point count surveys to estimate relative abundance, richness, and diversity. Our sampling design was informed by experimentally estimated carcass persistence times and detection probabilities. We used linear and generalized linear mixed models to evaluate how habitat features influenced community structure and how mortality was affected by window area and factors that correlated with community structure. The most-supported model was consistent for all community indices and included effects of season, development, and distance to vegetated lots. BWCs were related positively to window area and negatively to development. We documented mortalities for 16/72 (22%) species (34 total carcasses) recorded at buildings, and BWCs were greater for juveniles than adults. Based on the most-supported model of BWCs, the median number of annual predicted fatalities at study buildings was 3 (range = 0-52). These results suggest that patchily distributed environmental resources and levels of window area in buildings create spatial variation in BWCs within and among urban areas. Current mortality estimates place little emphasis on spatial variation, which precludes a fundamental understanding of the issue. To focus conservation efforts, we illustrate how knowledge of the structural and environmental factors that influence bird-window collisions can be used to

  1. Window area and development drive spatial variation in bird-window collisions in an urban landscape.

    Directory of Open Access Journals (Sweden)

    Stephen B Hager

    Full Text Available Collisions with windows are an important human-related threat to birds in urban landscapes. However, the proximate drivers of collisions are not well understood, and no study has examined spatial variation in mortality in an urban setting. We hypothesized that the number of fatalities at buildings varies with window area and habitat features that influence avian community structure. In 2010 we documented bird-window collisions (BWCs and characterized avian community structure at 20 buildings in an urban landscape in northwestern Illinois, USA. For each building and season, we conducted 21 daily surveys for carcasses and nine point count surveys to estimate relative abundance, richness, and diversity. Our sampling design was informed by experimentally estimated carcass persistence times and detection probabilities. We used linear and generalized linear mixed models to evaluate how habitat features influenced community structure and how mortality was affected by window area and factors that correlated with community structure. The most-supported model was consistent for all community indices and included effects of season, development, and distance to vegetated lots. BWCs were related positively to window area and negatively to development. We documented mortalities for 16/72 (22% species (34 total carcasses recorded at buildings, and BWCs were greater for juveniles than adults. Based on the most-supported model of BWCs, the median number of annual predicted fatalities at study buildings was 3 (range = 0-52. These results suggest that patchily distributed environmental resources and levels of window area in buildings create spatial variation in BWCs within and among urban areas. Current mortality estimates place little emphasis on spatial variation, which precludes a fundamental understanding of the issue. To focus conservation efforts, we illustrate how knowledge of the structural and environmental factors that influence bird-window

  2. On-chip real-time single-copy polymerase chain reaction in picoliter droplets

    Energy Technology Data Exchange (ETDEWEB)

    Beer, N R; Hindson, B; Wheeler, E; Hall, S B; Rose, K A; Kennedy, I; Colston, B

    2007-04-20

    The first lab-on-chip system for picoliter droplet generation and PCR amplification with real-time fluorescence detection has performed PCR in isolated droplets at volumes 10{sup 6} smaller than commercial real-time PCR systems. The system utilized a shearing T-junction in a silicon device to generate a stream of monodisperse picoliter droplets that were isolated from the microfluidic channel walls and each other by the oil phase carrier. An off-chip valving system stopped the droplets on-chip, allowing them to be thermal cycled through the PCR protocol without droplet motion. With this system a 10-pL droplet, encapsulating less than one copy of viral genomic DNA through Poisson statistics, showed real-time PCR amplification curves with a cycle threshold of {approx}18, twenty cycles earlier than commercial instruments. This combination of the established real-time PCR assay with digital microfluidics is ideal for isolating single-copy nucleic acids in a complex environment.

  3. Timetable Design for Minimizing Passenger Travel Time and Congestion for a Single Metro Line

    Directory of Open Access Journals (Sweden)

    Yi Shen

    2018-02-01

    Full Text Available This paper brings a proposal for a timetable optimization model for minimizing the passenger travel time and congestion for a single metro line under time-dependent demand. The model is an integer-programming model that systemically considers the passenger travel time, the capacity of trains, and the capacity of platforms. A multi-objective function and a recursive optimization method are presented to solve the optimization problem. Using the model we can obtain an efficient timetable with minimal passenger travel time and minimal number of congestion events on platforms. Moreover, by increasing the number of dispatches, the critical point from congestion state to free-flow state and the optimal timetable with minimal cost for avoiding congestion on platforms can be obtained. The effectiveness of the model is evaluated by a real example. A half-regular timetable with fixed headways in each operation period and an irregular timetable with unfixed headway are investigated for comparison.

  4. Study of time-frequency characteristics of single snores: extracting new information for sleep apnea diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Castillo Escario, Y.; Blanco Almazan, D.; Camara Vazquez, M.A.; Jane Campos, R.

    2016-07-01

    Obstructive sleep apnea (OSA) is a highly prevalent chronic disease, especially in elderly and obese population. Despite constituting a huge health and economic problem, most patients remain undiagnosed due to limitations in current strategies. Therefore, it is essential to find cost-effective diagnostic alternatives. One of these novel approaches is the analysis of acoustic snoring signals. Snoring is an early symptom of OSA which carries pathophysiological information of high diagnostic value. For this reason, the main objective of this work is to study the characteristics of single snores of different types, from healthy and OSA subjects. To do that, we analyzed snoring signals from previous databases and developed an experimental protocol to record simulated OSA-related sounds and characterize the response of two commercial tracheal microphones. Automatic programs for filtering, downsampling, event detection and time-frequency analysis were built in MATLAB. We found that time-frequency maps and spectral parameters (central, mean and peak frequency and energy in the 100-500 Hz band) allow distinguishing regular snores of healthy subjects from non-regular snores and snores of OSA subjects. Regarding the two commercial microphones, we found that one of them was a suitable snoring sensor, while the other had a too restricted frequency response. Future work shall include a higher number of episodes and subjects, but our study has contributed to show how important the differences between regular and non-regular snores can be for OSA diagnosis, and how much clinically relevant information can be extracted from time-frequency maps and spectral parameters of single snores. (Author)

  5. Timed Stair Climbing is the Single Strongest Predictor of Perioperative Complications in Patients Undergoing Abdominal Surgery

    Science.gov (United States)

    Reddy, Sushanth; Contreras, Carlo M; Singletary, Brandon; Bradford, T Miller; Waldrop, Mary G; Mims, Andrew H; Smedley, W Andrew; Swords, Jacob A; Thomas N, Wang; Martin J, Heslin

    2016-01-01

    Background Current methods to predict patients' peri-operative morbidity utilize complex algorithms with multiple clinical variables focusing primarily on organ-specific compromise. The aim of the present study is to determine the value of a timed stair climb (SC) in predicting peri-operative complications for patients undergoing abdominal surgery. Study Design From March 2014 to July 2015, 362 patients attempted SC while being timed prior to undergoing elective abdominal surgery. Vital signs were measured before and after SC. Ninety day post-operative complications were assessed by the Accordion Severity Grading System. The prognostic value of SC was compared to the ACS NSQIP risk calculator. Results A total of 264 (97.4%) patients were able to complete SC. SC time directly correlated to changes in both mean arterial pressure and heart rate as an indicator of stress. An Accordion grade 2 or higher complication occurred in 84 (25%) patients. There were 8 mortalities (2.4%). Patients with slower SC times had an increased complication rate (P<0.0001). In multivariable analysis SC time was the single strongest predictor of complications (OR=1.029, P<0.0001), and no other clinical co-morbidity reached statistical significance. Receiver operative characteristic curves predicting post-operative morbidity by SC time was superior to that of the ACS risk calculator (AUC 0.81 vs. 0.62, P<0.0001). Additionally slower patients had a greater deviation from predicted length of hospital stay (P=0.034) Conclusions SC provides measurable stress, accurately predicts post-operative complications, and is easy to administer in patients undergoing abdominal surgery. Larger patient populations with a diverse group of operations will be needed to further validate the use of SC in risk prediction models. PMID:26920993

  6. Real-Time Single-Frequency GPS/MEMS-IMU Attitude Determination of Lightweight UAVs

    Directory of Open Access Journals (Sweden)

    Christian Eling

    2015-10-01

    Full Text Available In this paper, a newly-developed direct georeferencing system for the guidance, navigation and control of lightweight unmanned aerial vehicles (UAVs, having a weight limit of 5 kg and a size limit of 1.5 m, and for UAV-based surveying and remote sensing applications is presented. The system is intended to provide highly accurate positions and attitudes (better than 5 cm and 0.5° in real time, using lightweight components. The main focus of this paper is on the attitude determination with the system. This attitude determination is based on an onboard single-frequency GPS baseline, MEMS (micro-electro-mechanical systems inertial sensor readings, magnetic field observations and a 3D position measurement. All of this information is integrated in a sixteen-state error space Kalman filter. Special attention in the algorithm development is paid to the carrier phase ambiguity resolution of the single-frequency GPS baseline observations. We aim at a reliable and instantaneous ambiguity resolution, since the system is used in urban areas, where frequent losses of the GPS signal lock occur and the GPS measurement conditions are challenging. Flight tests and a comparison to a navigation-grade inertial navigation system illustrate the performance of the developed system in dynamic situations. Evaluations show that the accuracies of the system are 0.05° for the roll and the pitch angle and 0.2° for the yaw angle. The ambiguities of the single-frequency GPS baseline can be resolved instantaneously in more than 90% of the cases.

  7. Real-time single-frequency GPS/MEMS-IMU attitude determination of lightweight UAVs.

    Science.gov (United States)

    Eling, Christian; Klingbeil, Lasse; Kuhlmann, Heiner

    2015-10-16

    In this paper, a newly-developed direct georeferencing system for the guidance, navigation and control of lightweight unmanned aerial vehicles (UAVs), having a weight limit of 5 kg and a size limit of 1.5 m, and for UAV-based surveying and remote sensing applications is presented. The system is intended to provide highly accurate positions and attitudes (better than 5 cm and 0.5°) in real time, using lightweight components. The main focus of this paper is on the attitude determination with the system. This attitude determination is based on an onboard single-frequency GPS baseline, MEMS (micro-electro-mechanical systems) inertial sensor readings, magnetic field observations and a 3D position measurement. All of this information is integrated in a sixteen-state error space Kalman filter. Special attention in the algorithm development is paid to the carrier phase ambiguity resolution of the single-frequency GPS baseline observations. We aim at a reliable and instantaneous ambiguity resolution, since the system is used in urban areas, where frequent losses of the GPS signal lock occur and the GPS measurement conditions are challenging. Flight tests and a comparison to a navigation-grade inertial navigation system illustrate the performance of the developed system in dynamic situations. Evaluations show that the accuracies of the system are 0.05° for the roll and the pitch angle and 0.2° for the yaw angle. The ambiguities of the single-frequency GPS baseline can be resolved instantaneously in more than 90% of the cases.

  8. Infrared monitoring of gyrotron windows

    International Nuclear Information System (INIS)

    Huey, H.; Lopez, N.; Hu, G.; Choi, E.; Mundie, L.

    1983-01-01

    A technique for monitoring the gyrotron output window surface temperature with an infrared camera while the gyrotron is in operation has been developed. The IR camera views the window through a perforated waveguide wall, and serves both as a guide for the safe operation at high average power of the tube, as well as an aid in the analysis of new window designs. Window temperatures were studied as a function of a number of parameters, including gun anode voltage, beam current, magnetic field, coolant flow, and load matching. The IR technique is applicable to many types of high average power microwave and millimeter wave tubes. Successful operation of the Varian 60 GHz gyrotron to 214 kW CW was guided by the infrared camera. Analyses on 28, 56 and 60 GHz gyrotrons have led to a number of design changes. A comparison with computer calculations is also presented

  9. Attosecond light sources in the water window

    Science.gov (United States)

    Ren, Xiaoming; Li, Jie; Yin, Yanchun; Zhao, Kun; Chew, Andrew; Wang, Yang; Hu, Shuyuan; Cheng, Yan; Cunningham, Eric; Wu, Yi; Chini, Michael; Chang, Zenghu

    2018-02-01

    As a compact and burgeoning alternative to synchrotron radiation and free-electron lasers, high harmonic generation (HHG) has proven its superiority in static and time-resolved extreme ultraviolet spectroscopy for the past two decades and has recently gained many interests and successes in generating soft x-ray emissions covering the biologically important water window spectral region. Unlike synchrotron and free-electron sources, which suffer from relatively long pulse width or large time jitter, soft x-ray sources from HHG could offer attosecond time resolution and be synchronized with their driving field to investigate time-resolved near edge absorption spectroscopy, which could reveal rich structural and dynamical information of the interrogated samples. In this paper, we review recent progresses on generating and characterizing attosecond light sources in the water window region. We show our development of an energetic, two-cycle, carrier-envelope phase stable laser source at 1.7 μm and our achievement in producing a 53 as soft x-ray pulse covering the carbon K-edge in the water window. Such source paves the ways for the next generation x-ray spectroscopy with unprecedented temporal resolution.

  10. Building America's Low-e Storm Window Adoption Program Plan (FY2014)

    Energy Technology Data Exchange (ETDEWEB)

    Cort, Katherine A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2013-12-23

    Low emissivity (low-e) storm windows/panels appear to hold promise for effectively reducing existing home heating, ventilation, and air-conditioning (HVAC) consumption. Due to the affordability of low-e storm windows and the large numbers of existing homes that have low-performing single-pane or double-pane clear windows, a tremendous opportunity exists to provide energy savings by transforming the low-e storm window market and increasing market adoption. This report outlines U.S. Department of Energy (DOE) Building America’s planned market transformation activities in support of low-e storm window adoption during fiscal year (FY) 2014.

  11. Feasibility study of a cryogenically cooled window for high-power gyrotrons

    International Nuclear Information System (INIS)

    Haste, G.R.; Kimrey, H.D.; Prosise, J.D.

    1986-07-01

    Single-crystal sapphire is currently in use as the material for output windows in high-power microwave tubes, particularly gyrotrons. These windows are currently being cooled by fluorocarbon fluids at near-room temperatures. There are, however, several advantages in operating the window at very low temperatures: less absorption and consequent heating of the window, greater material strength, improved resistance to crack formation, greater thermal conductivity, and reduced thermal expansion. Operation at cryogenic temperatures is shown to be feasible. The output power, which is currently limited by window constraints, could be increased by an order of magnitude or more

  12. Measurement system of correlation functions of microwave single photon source in real time

    Science.gov (United States)

    Korenkov, A.; Dmitriev, A.; Astafiev, O.

    2018-02-01

    Several quantum setups, such as quantum key distribution networks[1] and quantum simulators (e.g. boson sampling), by their design rely on single photon sources (SPSs). These quantum setups were demonstrated to operate in optical frequency domain. However, following the steady advances in circuit quantum electrodynamics, a proposal has been made recently[2] to demonstrate boson sampling with microwave photons. This in turn requires the development of reliable microwave SPS. It's one of the most important characteristics are the first-order and the second-order correlation functions g1 and g2. The measurement technique of g1 and g2 is significantly different from that in the optical domain [3],[4] because of the current unavailability of microwave single-photon detectors. In particular, due to high levels of noise present in the system a substantial amount of statistics in needed to be acquired. This work presents a platform for measurement of g1 and g2 that processes the incoming data in real time, maximizing the efficiency of data acquisition. The use of field-programmable gate array (FPGA) electronics, common in similar experiments[3] but complex in programming, is avoided; instead, the calculations are performed on a standard desktop computer. The platform is used to perform the measurements of the first-order and the second-order correlation functions of the microwave SPS.

  13. Sensitivity of bimodal listeners to interaural time differences with modulated single- and multiple-channel stimuli.

    Science.gov (United States)

    Francart, Tom; Lenssen, Anneke; Wouters, Jan

    2011-01-01

    In a previous study, it was shown that users of a cochlear implant and a contralateral hearing aid are sensitive to interaural time differences (ITDs). In the current study, we investigated (1) the influence on ITD sensitivity of bilaterally varying the place of excitation in the cochlea and of modulation frequency, and (2) the sensitivity to ITD with a 3-channel stimulus generated using continuous-interleaved-sampling (CIS)-like processing. The stimuli were (1) a high-frequency carrier (acoustic sinusoid and single-electrode electric pulse train), modulated with a half-wave-rectified low-frequency sinusoid (a so-called transposed stimulus), and (2) a 3-channel stimulus, generated by sending an acoustic click train through processing similar to the CIS strategy. Four bimodal listeners were sensitive to ITD for both stimulus types. For the first stimulus type, there was no significant influence on ITD sensitivity of the acoustic carrier frequency. Performance decreased with increasing modulation frequency with a limit of sensitivity at around 150-200 Hz. Sensitivity was similar for the single- and 3-channel stimulus. The results indicate the possibility of ITD perception with adapted clinical processors, which can lead to improved sound source localization and binaural unmasking. Copyright © 2010 S. Karger AG, Basel.

  14. Using the time shift in single pushbroom datatakes to detect ships and their heading

    Science.gov (United States)

    Willburger, Katharina A. M.; Schwenk, Kurt

    2017-10-01

    The detection of ships from remote sensing data has become an essential task for maritime security. The variety of application scenarios includes piracy, illegal fishery, ocean dumping and ships carrying refugees. While techniques using data from SAR sensors for ship detection are widely common, there is only few literature discussing algorithms based on imagery of optical camera systems. A ship detection algorithm for optical pushbroom data has been developed. It takes advantage of the special detector assembly of most of those scanners, which allows apart from the detection of a ship also the calculation of its heading out of a single acquisition. The proposed algorithm for the detection of moving ships was developed with RapidEye imagery. It algorithm consists mainly of three steps: the creation of a land-watermask, the object extraction and the deeper examination of each single object. The latter step is built up by several spectral and geometric filters, making heavy use of the inter-channel displacement typical for pushbroom sensors with multiple CCD lines, finally yielding a set of ships and their direction of movement. The working principle of time-shifted pushbroom sensors and the developed algorithm is explained in detail. Furthermore, we present our first results and give an outlook to future improvements.

  15. Anterior single-tooth dental implant restorations: now is the perfect time to recall significant contributions.

    Science.gov (United States)

    Sullivan, Daniel Y

    2003-01-01

    Significant contributions by clinicians, researchers, and manufacturers have brought us to a previously almost unimaginable point in time, where it is possible to place and restore a single dental implant in the esthetic zone with a success rate above 96% and with the probability that it will look very much like a natural tooth. In addition, in select cases it is possible to do the extraction, implant placement, and provisional restoration on the same day. There is very little trauma at the implant site, which results in greater comfort for the patient and ultimately greater tissue preservation long-term. We have now observed single-tooth anterior implant cases for 15 years and have every belief that these implants will continue to function in health for many years. So what is next? We will have to wait and see, but it is this clinician's hope that the next 15 years will bring us more of these cooperative efforts that have so dramatically improved our patients' lives.

  16. climwin: An R Toolbox for Climate Window Analysis

    Science.gov (United States)

    van de Pol, Martijn

    2016-01-01

    When studying the impacts of climate change, there is a tendency to select climate data from a small set of arbitrary time periods or climate windows (e.g., spring temperature). However, these arbitrary windows may not encompass the strongest periods of climatic sensitivity and may lead to erroneous biological interpretations. Therefore, there is a need to consider a wider range of climate windows to better predict the impacts of future climate change. We introduce the R package climwin that provides a number of methods to test the effect of different climate windows on a chosen response variable and compare these windows to identify potential climate signals. climwin extracts the relevant data for each possible climate window and uses this data to fit a statistical model, the structure of which is chosen by the user. Models are then compared using an information criteria approach. This allows users to determine how well each window explains variation in the response variable and compare model support between windows. climwin also contains methods to detect type I and II errors, which are often a problem with this type of exploratory analysis. This article presents the statistical framework and technical details behind the climwin package and demonstrates the applicability of the method with a number of worked examples. PMID:27973534

  17. Imaging windows for long-term intravital imaging

    Science.gov (United States)

    Alieva, Maria; Ritsma, Laila; Giedt, Randy J; Weissleder, Ralph; van Rheenen, Jacco

    2014-01-01

    Intravital microscopy is increasingly used to visualize and quantitate dynamic biological processes at the (sub)cellular level in live animals. By visualizing tissues through imaging windows, individual cells (e.g., cancer, host, or stem cells) can be tracked and studied over a time-span of days to months. Several imaging windows have been developed to access tissues including the brain, superficial fascia, mammary glands, liver, kidney, pancreas, and small intestine among others. Here, we review the development of imaging windows and compare the most commonly used long-term imaging windows for cancer biology: the cranial imaging window, the dorsal skin fold chamber, the mammary imaging window, and the abdominal imaging window. Moreover, we provide technical details, considerations, and trouble-shooting tips on the surgical procedures and microscopy setups for each imaging window and explain different strategies to assure imaging of the same area over multiple imaging sessions. This review aims to be a useful resource for establishing the long-term intravital imaging procedure. PMID:28243510

  18. Optimisation of sampling windows design for population pharmacokinetic experiments.

    Science.gov (United States)

    Ogungbenro, Kayode; Aarons, Leon

    2008-08-01

    This paper describes an approach for optimising sampling windows for population pharmacokinetic experiments. Sampling windows designs are more practical in late phase drug development where patients are enrolled in many centres and in out-patient clinic settings. Collection of samples under the uncontrolled environment at these centres at fixed times may be problematic and can result in uninformative data. Population pharmacokinetic sampling windows design provides an opportunity to control when samples are collected by allowing some flexibility and yet provide satisfactory parameter estimation. This approach uses information obtained from previous experiments about the model and parameter estimates to optimise sampling windows for population pharmacokinetic experiments within a space of admissible sampling windows sequences. The optimisation is based on a continuous design and in addition to sampling windows the structure of the population design in terms of the proportion of subjects in elementary designs, number of elementary designs in the population design and number of sampling windows per elementary design is also optimised. The results obtained showed that optimal sampling windows designs obtained using this approach are very efficient for estimating population PK parameters and provide greater flexibility in terms of when samples are collected. The results obtained also showed that the generalized equivalence theorem holds for this approach.

  19. A window on urban sustainability

    International Nuclear Information System (INIS)

    Stigt, Rien van; Driessen, Peter P.J.; Spit, Tejo J.M.

    2013-01-01

    Sustainable urban development requires the integration of environmental interests in urban planning. Although various methods of environmental assessment have been developed, plan outcomes are often disappointing due to the complex nature of decision-making in urban planning, which takes place in multiple arenas within multiple policy networks involving diverse stakeholders. We argue that the concept of ‘decision windows’ can structure this seemingly chaotic chain of interrelated decisions. First, explicitly considering the dynamics of the decision-making process, we further conceptualized decision windows as moments in an intricate web of substantively connected deliberative processes where issues are reframed within a decision-making arena, and interests may be linked within and across arenas. Adopting this perspective in two case studies, we then explored how decision windows arise, which factors determine their effectiveness and how their occurrence can be influenced so as to arrive at more sustainable solutions. We conclude that the integration of environmental interests in urban planning is highly dependent on the ability of the professionals involved to recognize and manipulate decision windows. Finally, we explore how decision windows may be opened. -- Highlights: • Decision-making about sustainable urban development occurs in networks. • The concept of ‘decision windows’ was further elaborated. • Decision windows help understand how environmental interests enter decision-making. • Decision windows can, to some extent, be influenced

  20. Moving scanning emitter tracking by a single observer using time of interception: Observability analysis and algorithm

    Directory of Open Access Journals (Sweden)

    Yifei ZHANG

    2017-06-01

    Full Text Available The target motion analysis (TMA for a moving scanning emitter with known fixed scan rate by a single observer using the time of interception (TOI measurements only is investigated in this paper. By transforming the TOI of multiple scan cycles into the direction difference of arrival (DDOA model, the observability analysis for the TMA problem is performed. Some necessary conditions for uniquely identifying the scanning emitter trajectory are obtained. This paper also proposes a weighted instrumental variable (WIV estimator for the scanning emitter TMA, which does not require any initial solution guess and is closed-form and computationally attractive. More importantly, simulations show that the proposed algorithm can provide estimation mean square error close to the Cramer-Rao lower bound (CRLB at moderate noise levels with significantly lower estimation bias than the conventional pseudo-linear least square (PLS estimator.