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Sample records for single residue bordering

  1. A KAS2 cDNA complements the phenotypes of the Arabidopsis fab1 mutant that differs in a single residue bordering the substrate binding pocket

    DEFF Research Database (Denmark)

    Carlsson, A.S.; LaBrie, S.T.; Kinney, A.J.

    2002-01-01

    The fab1 mutant of Arabidopsis is partially deficient in activity of ß-ketoacyl-[acyl carrier protein] synthase II (KAS II). This defect results in increased levels of 16 : 0 fatty acid and is associated with damage and death of the mutants at low temperature. Transformation of fab1 plants with a c......DNA from Brassica napus encoding a KAS II enzyme resulted in complementation of both mutant phenotypes. The dual complementation by expression of the single gene proves that low-temperature damage is a consequence of altered membrane unsaturation. The fab1 mutation is a single nucleotide change...... chain to bend. For functional analysis the equivalent Leu207Phe mutation was introduced into the fabB gene encoding the E. coli KAS I enzyme. Compared to wild-type, the Leu207Phe protein showed a 10-fold decrease in binding affinity for the fatty acid substrate, exhibited a modified behavior during size...

  2. Drop coalescence and liquid flow in a single Plateau border

    Science.gov (United States)

    Cohen, Alexandre; Fraysse, Nathalie; Raufaste, Christophe

    2015-05-01

    We report a comprehensive study of the flow of liquid triggered by injecting a droplet into a liquid foam microchannel, also called a Plateau border. This drop-injected experiment reveals an intricate dynamics for the liquid redistribution, with two contrasting regimes observed, ruled either by inertia or viscosity. We devoted a previous study [A. Cohen et al., Phys. Rev. Lett. 112, 218303 (2014), 10.1103/PhysRevLett.112.218303] to the inertial imbibition regime, unexpected at such small length scales. Here we report other features of interest of the drop-injected experiment, related to the coalescence of the droplet with the liquid microchannel, to both the inertial and viscous regimes, and to the occurrence of liquid flow through the soap films as well as effects of the interfacial rheology. The transition between the two regimes is investigated and qualitatively accounted for. The relevance of our results to liquid foam drainage is tackled by considering the flow of liquid at the nodes of the network of interconnected microchannels. Extensions of our study to liquid foams are discussed.

  3. Palinspastic reconstruction and geological evolution of Permian residual marine basins bordering China and Mongolia

    Directory of Open Access Journals (Sweden)

    Gen-Yao Wu

    2014-04-01

    Full Text Available One main feature of the tectono-paleogeographic evolution of the southern branch of the Paleo-Asian Ocean was that there developed residual marine basins in former backarc/forearc regions after the disappearance of oceanic crust. The paper illustrates the viewpoint taking the evolution of Dalandzadgad and Solonker oceanic basins as examples. The Dalandzadgad ocean subducted southwards during the Silurian-Devonian, created an intra-oceanic arc and a backarc basin in southern Mongolia. In addition, a continent marginal arc formed along the national boundary between China and Mongolia, the south of which was a backarc basin. The oceanic basin closed and arc–arc (continent collision occurred during the early Early Permian, followed by two residual marine basins developing in the former backarc regions, named the South Gobi Basin in southern Mongolia and the Guaizihu Basin in western Inner Mongolia. The Solonker ocean subducted southwards and finally disappeared during the early Middle Permian. Afterwards, two residual marine basins occurred in northern China, the Zhesi Basin being situated in the former backarc region and the Wujiatun Basin in the former forearc region. The late Middle Permian was the most optimum period for the developing residual marine basins, when they covered a vast area. The basin evolution differentiated during the early Late Permian, with a general trend of uplift in the east and of subsidence in the west. The Upper Permian in the South Gobi Basin was characterized by coal-bearing strata hosting economically valuable coal fields. A transgression invaded westwards and the Chandmani-Bayanleg Basin was created in southwest Mongolia during the middle-late stage of the Late Permian. Correspondingly, the coal formation entered a flourishing time, with thick coal beds and sedimentary interbeds. All of these basins, namely, both the marine and nonmarine residual basins, reversed and closed by the end of Permian.

  4. Analysis of residual stress state in sheet metal parts processed by single point incremental forming

    Science.gov (United States)

    Maaß, F.; Gies, S.; Dobecki, M.; Brömmelhoff, K.; Tekkaya, A. E.; Reimers, W.

    2018-05-01

    The mechanical properties of formed metal components are highly affected by the prevailing residual stress state. A selective induction of residual compressive stresses in the component, can improve the product properties such as the fatigue strength. By means of single point incremental forming (SPIF), the residual stress state can be influenced by adjusting the process parameters during the manufacturing process. To achieve a fundamental understanding of the residual stress formation caused by the SPIF process, a valid numerical process model is essential. Within the scope of this paper the significance of kinematic hardening effects on the determined residual stress state is presented based on numerical simulations. The effect of the unclamping step after the manufacturing process is also analyzed. An average deviation of the residual stress amplitudes in the clamped and unclamped condition of 18 % reveals, that the unclamping step needs to be considered to reach a high numerical prediction quality.

  5. Virtual Campus Hub: A single sign-on system for cross-border collaboration

    DEFF Research Database (Denmark)

    Badger, Merete; Vercoulen, F.; Monaco, L.

    2013-01-01

    laboratory exercises, examination tools, courses, collaboration tools, and tools to support the incubation of new small or medium size enterprises (SMEs). All of the applications serve as use cases for the demonstration of how the technology behind Virtual Campus Hub works. They can be accessed via...... in connection with joint educational programs and courses. These experiences are gained through a series of virtual events where users from the partners are invited to test each other’s applications. So far, testing of remote laboratory exercises, examination tools and an online course in wind energy has shown......Four technical universities in Europe work together in the EU-funded project Virtual Campus Hub (FP7 RI-283746, www.virtualcampushub.eu) to lower the technical barriers for cross-border collaboration. Universities have many connections to the outside world (e.g. to other universities, to joint...

  6. Single Stage Silicone Border Molded Closed Mouth Impression Technique-Part II.

    Science.gov (United States)

    Solomon, E G R

    2011-09-01

    Functioning of a complete denture depends to a great extent on the impression technique. Several impression techniques have been described in the literature since the turn of this century when Greene [Clinical courses in dental prothesis, 1916] brothers introduced the first scientific system of recording dental impression. Advocates of each technique have their own claim of superiority over the other. The introduction of elastomeric impression materials [Skinner and Cooper, J Am Dent Assoc 51:523-536, 1955] has made possible new techniques of recording impression for complete denture construction. These rubber like materials are of two types; one has a polysulfide base and is popularily known as polysulfide rubber (Thiokol and Mercaptan). The other variety has a silicone base known as silicone rubber or silicone elastomer. Silicone elastomers are available in four different consistencies; a thin easy flowing light bodied material,a creamy medium bodied material, a highly viscous heavy bodied material and a kneadable putty material. This paper describes an active closed mouth impression technique with one stage border molding using putty silicone material as a substitute for low fusing compound.

  7. Effect of residual stress on the nanoindentation response of (100) copper single crystal

    International Nuclear Information System (INIS)

    Zhu, Li-na; Xu, Bin-shi; Wang, Hai-dou; Wang, Cheng-biao

    2012-01-01

    Experimental measurements were used to investigate the effect of residual stress on the nanoindentation of (100) copper single crystal. Equi-biaxial tensile and compressive stresses were applied to the copper single crystal using a special designed apparatus. It was found that residual stresses greatly affected peak load, curvature of the loading curve, elastically recovered depth, residual depth, indentation work, pile-up amount and contact area. The Suresh and Giannakopoulos and Lee and Kwon methods were used to calculate the residual stresses from load-depth data and morphology observation of nanoindents using atomic force microscopy. Comparison of the obtained results with stress values from strain gage showed that the residual stresses analyzed from the Suresh and Giannakopoulos model agreed well with the applied stresses. -- Highlights: ► Residual stresses greatly affected various nanoindentation parameters. ► The contact area can be accurately measured from AFM observation. ► The residual stresses analyzed from the S and G model agreed well with applied stresses.

  8. Residual Stress State in Single-Edge Notched Tension Specimen Caused by the Local Compression Technique

    Directory of Open Access Journals (Sweden)

    Huang Yifan

    2016-12-01

    Full Text Available Three-dimensional (3D finite element analyses (FEA are performed to simulate the local compression (LC technique on the clamped single-edge notched tension (SE(T specimens. The analysis includes three types of indenters, which are single pair of cylinder indenters (SPCI, double pairs of cylinder indenters (DPCI and single pair of ring indenters (SPRI. The distribution of the residual stress in the crack opening direction in the uncracked ligament of the specimen is evaluated. The outcome of this study can facilitate the use of LC technique on SE(T specimens.

  9. Contaminant Release from Residual Waste in Single Shell Tanks at the Hanford Site, Washington, USA - 9276

    International Nuclear Information System (INIS)

    Cantrell, Kirk J.; Krupka, Kenneth M.; Deutsch, William J.; Lindberg, Michael J.

    2009-01-01

    Determinations of elemental and solid-phase compositions, and contaminant release studies have been applied in an ongoing study of residual tank wastes (i.e., waste remaining after final retrieval operations) from five of 149 underground single-shell storage tanks (241-C-103, 241-C-106, 241-C-202, 241-C-203, and 241-S-112) at the U.S. Department of Energy's Hanford Site in Washington State. This work is being conducted to support performance assessments that will be required to evaluate long-term health and safety risks associated with tank site closure. The results of studies completed to date show significant variability in the compositions, solid phase properties, and contaminant release characteristics from these residual tank wastes. This variability is the result of differences in waste chemistry/composition of wastes produced from several different spent fuel reprocessing schemes, subsequent waste reprocessing to remove certain target constituents, tank farm operations that concentrated wastes and mixed wastes between tanks, and differences in retrieval processes used to remove the wastes from the tanks. Release models were developed based upon results of chemical characterization of the bulk residual waste, solid-phase characterization (see companion paper 9277 by Krupka et al.), leaching and extraction experiments, and geochemical modeling. In most cases empirical release models were required to describe contaminant release from these wastes. Release of contaminants from residual waste was frequently found to be controlled by the solubility of phases that could not be identified and/or for which thermodynamic data and/or dissolution rates have not been measured. For example, significant fractions of Tc-99, I-129, and Cr appear to be coprecipitated at trace concentrations in metal oxide phases that could not be identified unambiguously. In the case of U release from tank 241-C-103 residual waste, geochemical calculations indicated that leachate

  10. Investigations of Residual Stresses and Mechanical Properties of Single Crystal Niobium for SRF Cavities

    Science.gov (United States)

    Gnäupel-Herold, Thomas; Myneni, Ganapati Rao; Ricker, Richard E.

    2007-08-01

    This work investigates properties of large grained, high purity niobium with respect to the forming of superconducting radio frequency (SRF) cavities from such large grained sheets. The yield stresses were examined using tensile specimens that were essentially single crystals in orientations evenly distributed in the standard projection triangle. No distinct yield anisotropy was found, however, vacuum annealing increased the yield strength by a factor 2…3. The deep drawing forming operation of the half cells raises the issues of elastic shape changes after the release of the forming tool (springback) and residual stresses, both of which are indicated to be negligible. This is a consequence of the low yield stress (sheet metal forming). However, the significant anisotropy of the transversal plastic strains after uniaxial deformation points to potentially critical thickness variations for large grained / single crystal half cells, thus raising the issue of controlling grain orientation or using single crystal sheet material.

  11. Border markets

    DEFF Research Database (Denmark)

    Walther, Olivier

    2014-01-01

    The objective of this issue of Articulo – Journal of Urban Research is to examine the characteristics of border markets in a comparative perspective. In this introductory paper, I first discuss what makes African border markets different from other markets, and examine several factors that explain...... their unequal economic development: the presence of a trade community, the combination of trading and productive activities, and the relative porosity of borders. In a second part, I examine how border markets on the U.S.-Mexico border must simultaneously guarantee the security of the state while favoring...... regional trade. The last part of the paper argues that more policy attention should be paid to border markets which, despite being at the margin of states, are a vital component of their economy. Fifty years after most West African states became independent and just as NAFTA turns 20, it is high time...

  12. Residual strain evolution during the deformation of single fiber metal matrix composites

    Energy Technology Data Exchange (ETDEWEB)

    Hanan, J.C.; Uestuendag, E.; Clausen, B. [Dept. of Materials Science, California Inst. of Tech., Pasadena, CA (United States); Sivasambu, M.; Beyerlein, I.J. [Theoretical Div., Los Alamos National Lab., Los Alamos, NM (United States); Brown, D.W.; Bourke, M.A.M. [Materials Science and Technology Div., Los Alamos National Lab., Los Alamos, NM (United States)

    2002-07-01

    Successful application of metal matrix composites often requires strength and lifetime predictions that account for the deformation of each phase. Yet, the deformation of individual phases in composites usually differs significantly from their respective monolithic behaviors. An approach is presented that quantifies the deformation parameters of each phase using neutron diffraction measurements before, during, and after failure under tensile loading in model composites consisting of a single alumina fiber embedded in an aluminum matrix. The evolution of residual strains after loading was examined including the effects of fiber failure. (orig.)

  13. Analysis of cosmetic residues on a single human hair by ATR FT-IR microspectroscopy

    Science.gov (United States)

    Pienpinijtham, Prompong; Thammacharoen, Chuchaat; Naranitad, Suwimol; Ekgasit, Sanong

    2018-05-01

    In this work, ATR FT-IR spectra of single human hair and cosmetic residues on hair surface are successfully collected using a homemade dome-shaped Ge μIRE accessary installed on an infrared microscope. By collecting ATR spectra of hairs from the same person, the spectral patterns are identical and superimposed while different spectral features are observed from ATR spectra of hairs collected from different persons. The spectral differences depend on individual hair characteristics, chemical treatments, and cosmetics on hair surface. The "Contact-and-Collect" technique that transfers remarkable materials on the hair surface to the tip of the Ge μIRE enables an identification of cosmetics on a single hair. Moreover, the differences between un-split and split hairs are also studied in this report. These highly specific spectral features can be employed for unique identification or for differentiation of hairs based on the molecular structures of hairs and cosmetics on hairs.

  14. Effects of residual aberrations explored on single-walled carbon nanotubes

    International Nuclear Information System (INIS)

    Biskupek, Johannes; Hartel, Peter; Haider, Maximilian; Kaiser, Ute

    2012-01-01

    The effects of geometric residual aberrations such as coma B 2 and two-fold astigmatism A 1 on the contrast in aberration corrected high resolution transmission electron microscopy (HRTEM) images are investigated on single-walled carbon nanotubes (SWNT). The individual aberrations are adjusted and set up manually using an imaging C S -corrector. We demonstrate how coma B 2 can be recognized by an experienced user directly in the image and how it blurs the contrast. Even with uncorrected (resolution limiting) spherical aberration C S the coma B 2 has to be considered and must be minimized. Limits for a tolerable coma are given. The experiments are confirmed by image simulations. -- Highlights: ► Individual effects of residual aberrations such as B 2 , A 1 , and C S are demonstrated. ► Experimental HRTEM and simulated images of carbon nanotubes are compared. ► A detection limit of 50 nm B 2 in a single HRTEM image is determined.

  15. Single-well experimental design for studying residual trapping of superciritcal carbon dioxide

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Y.; Freifeld, B.; Finsterle, S.; Leahy, M.; Ennis-King, J.; Paterson, L.; Dance, T.

    2010-06-15

    The objective of our research is to design a single-well injection-withdrawal test to evaluate residual phase trapping at potential CO{sub 2} geological storage sites. Given the significant depths targeted for CO{sub 2} storage and the resulting high costs associated with drilling to those depths, it is attractive to develop a single-well test that can provide data to assess reservoir properties and reduce uncertainties in the appraisal phase of site investigation. The main challenges in a single-well test design include (1) difficulty in quantifying the amount of CO{sub 2} that has dissolved into brine or migrated away from the borehole; (2) non-uniqueness and uncertainty in the estimate of the residual gas saturation (S{sub gr}) due to correlations among various parameters; and (3) the potential biased S{sub gr} estimate due to unaccounted heterogeneity of the geological medium. To address each of these challenges, we propose (1) to use a physical-based model to simulation test sequence and inverse modeling to analyze data information content and to quantify uncertainty; (2) to jointly use multiple data types generated from different kinds of tests to constrain the Sgr estimate; and (3) to reduce the sensitivity of the designed tests to geological heterogeneity by conducting the same test sequence in both a water-saturated system and a system with residual gas saturation. To perform the design calculation, we build a synthetic model and conduct a formal analysis for sensitivity and uncertain quantification. Both parametric uncertainty and geological uncertainty are considered in the analysis. Results show (1) uncertainty in the estimation of Sgr can be reduced by jointly using multiple data types and repeated tests; and (2) geological uncertainty is essential and needs to be accounted for in the estimation of S{sub gr} and its uncertainty. The proposed methodology is applied to the design of a CO{sub 2} injection test at CO2CRC's Otway Project Site, Victoria

  16. Border installations

    International Nuclear Information System (INIS)

    Lenaerts, Koen

    1988-01-01

    Border installations cover all nuclear plants located near the border with a neighbouring state. However, the actual distance depends on the context. The distance can vary considerably. Also the prohibition on siting near a heavily populated area also defines the actual distance variably. The distance criteria may be modified by other factors of topography, prevailing climate and so on. Various examples which illustrate the problems are given. For example, the Creys-Melville nuclear power plant is 80km from Geneva and the Cattonam installation is 12km from the French border with Luxembourg and Germany. The Cattenom case is explained and the legal position within the European Institutions is discussed. The French licensing procedures for nuclear power stations are described with special reference to the Cattenom power plant. Border installations are discussed in the context of European Community Law and Public International Law. (U.K.)

  17. Investigations of Residual Stresses and Mechanical Properties of Single Crystal Niobium for SRF Cavities

    International Nuclear Information System (INIS)

    Gnaeupel-Herold, Thomas; Myneni, Ganapati Rao; Ricker, Richard E.

    2007-01-01

    This work investigates properties of large grained, high purity niobium with respect to the forming of superconducting radio frequency (SRF) cavities from such large grained sheets. The yield stresses were examined using tensile specimens that were essentially single crystals in orientations evenly distributed in the standard projection triangle. No distinct yield anisotropy was found, however, vacuum annealing increased the yield strength by a factor 2...3. The deep drawing forming operation of the half cells raises the issues of elastic shape changes after the release of the forming tool (springback) and residual stresses, both of which are indicated to be negligible. This is a consequence of the low yield stress (< 100 MPa) and the large thickness (compared to typical thicknesses in sheet metal forming). However, the significant anisotropy of the transversal plastic strains after uniaxial deformation points to potentially critical thickness variations for large grained / single crystal half cells, thus raising the issue of controlling grain orientation or using single crystal sheet material

  18. Residual toxicity in hematopoietic cells following a single dose of methylnitrosourea

    Energy Technology Data Exchange (ETDEWEB)

    Inoue, T.; Cronkite, E.P.; Commerford, S.L.; Carsten, A.L.

    1984-01-01

    The residual injury to the proliferation capability of hemopoietic stem cells (CFU-S) which results from their exposure to leukemogenic agents was evaluated in mice given a single leukemogenic dose of methol nitrosourea. Bone marrow cellularity, splenic weight, number of CFU-S and the proportion of cycling to noncycling CFU-S were measured in an effort to detect acute and residual injury to the CFU-S from mice given MNU 21 and 3 days earlier. Marrow cells were also transferred into lethally irradiated mice to observe the self-renewal capability of the CFU-S in the recipient spleen and bone marrow. The results of these measurements show that the CFU-S in marrow from mice given 50 mg/kg of MNU 21 days earlier still have a defective ability for self-renewal, although the total cellularity, number of CFU-S and proportion of cycling and noncycling CFU-S in the donor have returned to the normal range. The relationship of this self-renewal defect to the development of leukemia after this leukemogenic dose of MNU is not known. 21 references, 9 figures, 3 tables.

  19. Analysis of cosmetic residues on a single human hair by ATR FT-IR microspectroscopy.

    Science.gov (United States)

    Pienpinijtham, Prompong; Thammacharoen, Chuchaat; Naranitad, Suwimol; Ekgasit, Sanong

    2018-05-15

    In this work, ATR FT-IR spectra of single human hair and cosmetic residues on hair surface are successfully collected using a homemade dome-shaped Ge μIRE accessary installed on an infrared microscope. By collecting ATR spectra of hairs from the same person, the spectral patterns are identical and superimposed while different spectral features are observed from ATR spectra of hairs collected from different persons. The spectral differences depend on individual hair characteristics, chemical treatments, and cosmetics on hair surface. The "Contact-and-Collect" technique that transfers remarkable materials on the hair surface to the tip of the Ge μIRE enables an identification of cosmetics on a single hair. Moreover, the differences between un-split and split hairs are also studied in this report. These highly specific spectral features can be employed for unique identification or for differentiation of hairs based on the molecular structures of hairs and cosmetics on hairs. Copyright © 2018 Elsevier B.V. All rights reserved.

  20. Functional diversity of Csk, Chk, and Src SH2 domains due to a single residue variation.

    Science.gov (United States)

    Ayrapetov, Marina K; Nam, Nguyen Hai; Ye, Guofeng; Kumar, Anil; Parang, Keykavous; Sun, Gongqin

    2005-07-08

    The C-terminal Src kinase (Csk) family of protein tyrosine kinases contains two members: Csk and Csk homologous kinase (Chk). Both phosphorylate and inactivate Src family kinases. Recent reports suggest that the Src homology (SH) 2 domains of Csk and Chk may bind to different phosphoproteins, which provides a basis for different cellular functions for Csk and Chk. To verify and characterize such a functional divergence, we compared the binding properties of the Csk, Chk, and Src SH2 domains and investigated the structural basis for the functional divergence. First, the study demonstrated striking functional differences between the Csk and Chk SH2 domains and revealed functional similarities between the Chk and Src SH2 domains. Second, structural analysis and mutagenic studies revealed that the functional differences among the three SH2 domains were largely controlled by one residue, Glu127 in Csk, Ile167 in Chk, and Lys200 in Src. Mutating these residues in the Csk or Chk SH2 domain to the Src counterpart resulted in dramatic gain of function similar to Src SH2 domain, whereas mutating Lys200 in Src SH2 domain to Glu (the Csk counterpart) resulted in loss of Src SH2 function. Third, a single point mutation of E127K rendered Csk responsive to activation by a Src SH2 domain ligand. Finally, the optimal phosphopeptide sequence for the Chk SH2 domain was determined. These results provide a compelling explanation for the functional differences between two homologous protein tyrosine kinases and reveal a new structure-function relationship for the SH2 domains.

  1. High frequency of a single nucleotide substitution (c.-6-180T>G) of the canine MDR1/ABCB1 gene associated with phenobarbital-resistant idiopathic epilepsy in Border Collie dogs.

    Science.gov (United States)

    Mizukami, Keijiro; Yabuki, Akira; Chang, Hye-Sook; Uddin, Mohammad Mejbah; Rahman, Mohammad Mahbubur; Kushida, Kazuya; Kohyama, Moeko; Yamato, Osamu

    2013-01-01

    A single nucleotide substitution (c.-6-180T>G) associated with resistance to phenobarbital therapy has been found in the canine MDR1/ABCB1 gene in Border Collies with idiopathic epilepsy. In the present study, a PCR-restriction fragment length polymorphism assay was developed for genotyping this mutation, and a genotyping survey was carried out in a population of 472 Border Collies in Japan to determine the current allele frequency. The survey demonstrated the frequencies of the T/T wild type, T/G heterozygote, and G/G mutant homozygote to be 60.0%, 30.3%, and 9.8%, respectively, indicating that the frequency of the mutant G allele is extremely high (24.9%) in Border Collies. The results suggest that this high mutation frequency of the mutation is likely to cause a high prevalence of phenobarbital-resistant epilepsy in Border Collies.

  2. High Frequency of a Single Nucleotide Substitution (c.-6-180T>G of the Canine MDR1/ABCB1 Gene Associated with Phenobarbital-Resistant Idiopathic Epilepsy in Border Collie Dogs

    Directory of Open Access Journals (Sweden)

    Keijiro Mizukami

    2013-01-01

    Full Text Available A single nucleotide substitution (c.-6-180T>G associated with resistance to phenobarbital therapy has been found in the canine MDR1/ABCB1 gene in Border Collies with idiopathic epilepsy. In the present study, a PCR-restriction fragment length polymorphism assay was developed for genotyping this mutation, and a genotyping survey was carried out in a population of 472 Border Collies in Japan to determine the current allele frequency. The survey demonstrated the frequencies of the T/T wild type, T/G heterozygote, and G/G mutant homozygote to be 60.0%, 30.3%, and 9.8%, respectively, indicating that the frequency of the mutant G allele is extremely high (24.9% in Border Collies. The results suggest that this high mutation frequency of the mutation is likely to cause a high prevalence of phenobarbital-resistant epilepsy in Border Collies.

  3. A single amino acid residue controls Ca2+ signaling by an octopamine receptor from Drosophila melanogaster.

    Science.gov (United States)

    Hoff, Max; Balfanz, Sabine; Ehling, Petra; Gensch, Thomas; Baumann, Arnd

    2011-07-01

    Rhythmic activity of cells and cellular networks plays an important role in physiology. In the nervous system oscillations of electrical activity and/or second messenger concentrations are important to synchronize neuronal activity. At the molecular level, rhythmic activity can be initiated by different routes. We have recently shown that an octopamine-activated G-protein-coupled receptor (GPCR; DmOctα1Rb, CG3856) from Drosophila initiates Ca(2+) oscillations. Here, we have unraveled the molecular basis of cellular Ca(2+) signaling controlled by the DmOctα1Rb receptor using a combination of pharmacological intervention, site-directed mutagenesis, and functional cellular Ca(2+) imaging on heterologously expressed receptors. Phosphorylation of a single amino acid residue in the third intracellular loop of the GPCR by PKC is necessary and sufficient to desensitize the receptor. From its desensitized state, DmOctα1Rb is resensitized by dephosphorylation, and a new Ca(2+) signal occurs on octopamine stimulation. Our findings show that transient changes of the receptor's surface profile have a strong effect on its physiological signaling properties. We expect that the detailed knowledge of DmOctα1Rb-dependent signal transduction fosters the identification of specific drugs that can be used for GPCR-mediated pest control, since octopamine serves important physiological and behavioral functions in arthropods.

  4. Regulatory Closure Options for the Residue in the Hanford Site Single-Shell Tanks

    International Nuclear Information System (INIS)

    Cochran, J.R.; Shyr, L.J.

    1998-01-01

    Liquid, mixed, high-level radioactive waste (HLW) has been stored in 149 single-shell tanks (SSTS) located in tank farms on the U.S. Department of Energy's (DOE's) Hanford Site. The DOE is developing technologies to retrieve as much remaining HLW as technically possible prior to physically closing the tank farms. In support of the Hanford Tanks Initiative, Sandia National Laboratories has addressed the requirements for the regulatory closure of the radioactive component of any SST residue that may remain after physical closure. There is significant uncertainty about the end state of each of the 149 SSTS; that is, the nature and amount of wastes remaining in the SSTS after retrieval is uncertain. As a means of proceeding in the face of these uncertainties, this report links possible end-states with associated closure options. Requirements for disposal of HLW and low-level radioactive waste (LLW) are reviewed in detail. Incidental waste, which is radioactive waste produced incidental to the further processing of HLW, is then discussed. If the low activity waste (LAW) fraction from the further processing of HLW is determined to be incidental waste, then DOE can dispose of that incidental waste onsite without a license from the U.S. Nuclear Regulatory Commissions (NRC). The NRC has proposed three Incidental Waste Criteria for determining if a LAW fraction is incidental waste. One of the three Criteria is that the LAW fraction should not exceed the NRC's Class C limits

  5. Regulatory Closure Options for the Residue in the Hanford Site Single-Shell Tanks

    Energy Technology Data Exchange (ETDEWEB)

    Cochran, J.R. Shyr, L.J.

    1998-10-05

    Liquid, mixed, high-level radioactive waste (HLW) has been stored in 149 single-shell tanks (SSTS) located in tank farms on the U.S. Department of Energy's (DOE's) Hanford Site. The DOE is developing technologies to retrieve as much remaining HLW as technically possible prior to physically closing the tank farms. In support of the Hanford Tanks Initiative, Sandia National Laboratories has addressed the requirements for the regulatory closure of the radioactive component of any SST residue that may remain after physical closure. There is significant uncertainty about the end state of each of the 149 SSTS; that is, the nature and amount of wastes remaining in the SSTS after retrieval is uncertain. As a means of proceeding in the face of these uncertainties, this report links possible end-states with associated closure options. Requirements for disposal of HLW and low-level radioactive waste (LLW) are reviewed in detail. Incidental waste, which is radioactive waste produced incidental to the further processing of HLW, is then discussed. If the low activity waste (LAW) fraction from the further processing of HLW is determined to be incidental waste, then DOE can dispose of that incidental waste onsite without a license from the U.S. Nuclear Regulatory Commissions (NRC). The NRC has proposed three Incidental Waste Criteria for determining if a LAW fraction is incidental waste. One of the three Criteria is that the LAW fraction should not exceed the NRC's Class C limits.

  6. Effect of increased exposure times on amount of residual monomer released from single-step self-etch adhesives.

    Science.gov (United States)

    Altunsoy, Mustafa; Botsali, Murat Selim; Tosun, Gonca; Yasar, Ahmet

    2015-10-16

    The aim of this study was to evaluate the effect of increased exposure times on the amount of residual Bis-GMA, TEGDMA, HEMA and UDMA released from single-step self-etch adhesive systems. Two adhesive systems were used. The adhesives were applied to bovine dentin surface according to the manufacturer's instructions and were polymerized using an LED curing unit for 10, 20 and 40 seconds (n = 5). After polymerization, the specimens were stored in 75% ethanol-water solution (6 mL). Residual monomers (Bis-GMA, TEGDMA, UDMA and HEMA) that were eluted from the adhesives (after 10 minutes, 1 hour, 1 day, 7 days and 30 days) were analyzed by high-performance liquid chromatography (HPLC). The data were analyzed using 1-way analysis of variance and Tukey HSD tests. Among the time periods, the highest amount of released residual monomers from adhesives was observed in the 10th minute. There were statistically significant differences regarding released Bis-GMA, UDMA, HEMA and TEGDMA between the adhesive systems (p<0.05). There were no significant differences among the 10, 20 and 40 second polymerization times according to their effect on residual monomer release from adhesives (p>0.05). Increasing the polymerization time did not have an effect on residual monomer release from single-step self-etch adhesives.

  7. The mining of toxin-like polypeptides from EST database by single residue distribution analysis.

    Science.gov (United States)

    Kozlov, Sergey; Grishin, Eugene

    2011-01-31

    Novel high throughput sequencing technologies require permanent development of bioinformatics data processing methods. Among them, rapid and reliable identification of encoded proteins plays a pivotal role. To search for particular protein families, the amino acid sequence motifs suitable for selective screening of nucleotide sequence databases may be used. In this work, we suggest a novel method for simplified representation of protein amino acid sequences named Single Residue Distribution Analysis, which is applicable both for homology search and database screening. Using the procedure developed, a search for amino acid sequence motifs in sea anemone polypeptides was performed, and 14 different motifs with broad and low specificity were discriminated. The adequacy of motifs for mining toxin-like sequences was confirmed by their ability to identify 100% toxin-like anemone polypeptides in the reference polypeptide database. The employment of novel motifs for the search of polypeptide toxins in Anemonia viridis EST dataset allowed us to identify 89 putative toxin precursors. The translated and modified ESTs were scanned using a special algorithm. In addition to direct comparison with the motifs developed, the putative signal peptides were predicted and homology with known structures was examined. The suggested method may be used to retrieve structures of interest from the EST databases using simple amino acid sequence motifs as templates. The efficiency of the procedure for directed search of polypeptides is higher than that of most currently used methods. Analysis of 39939 ESTs of sea anemone Anemonia viridis resulted in identification of five protein precursors of earlier described toxins, discovery of 43 novel polypeptide toxins, and prediction of 39 putative polypeptide toxin sequences. In addition, two precursors of novel peptides presumably displaying neuronal function were disclosed.

  8. The mining of toxin-like polypeptides from EST database by single residue distribution analysis

    Directory of Open Access Journals (Sweden)

    Grishin Eugene

    2011-01-01

    Full Text Available Abstract Background Novel high throughput sequencing technologies require permanent development of bioinformatics data processing methods. Among them, rapid and reliable identification of encoded proteins plays a pivotal role. To search for particular protein families, the amino acid sequence motifs suitable for selective screening of nucleotide sequence databases may be used. In this work, we suggest a novel method for simplified representation of protein amino acid sequences named Single Residue Distribution Analysis, which is applicable both for homology search and database screening. Results Using the procedure developed, a search for amino acid sequence motifs in sea anemone polypeptides was performed, and 14 different motifs with broad and low specificity were discriminated. The adequacy of motifs for mining toxin-like sequences was confirmed by their ability to identify 100% toxin-like anemone polypeptides in the reference polypeptide database. The employment of novel motifs for the search of polypeptide toxins in Anemonia viridis EST dataset allowed us to identify 89 putative toxin precursors. The translated and modified ESTs were scanned using a special algorithm. In addition to direct comparison with the motifs developed, the putative signal peptides were predicted and homology with known structures was examined. Conclusions The suggested method may be used to retrieve structures of interest from the EST databases using simple amino acid sequence motifs as templates. The efficiency of the procedure for directed search of polypeptides is higher than that of most currently used methods. Analysis of 39939 ESTs of sea anemone Anemonia viridis resulted in identification of five protein precursors of earlier described toxins, discovery of 43 novel polypeptide toxins, and prediction of 39 putative polypeptide toxin sequences. In addition, two precursors of novel peptides presumably displaying neuronal function were disclosed.

  9. Correlation Between the Microstructural Defects and Residual Stress in a Single Crystal Nickel-Based Superalloy During Different Creep Stages

    Science.gov (United States)

    Mo, Fangjie; Wu, Erdong; Zhang, Changsheng; Wang, Hong; Zhong, Zhengye; Zhang, Jian; Chen, Bo; Hofmann, Michael; Gan, Weimin; Sun, Guangai

    2018-03-01

    The present work attempts to reveal the correlation between the microstructural defects and residual stress in the single crystal nickel-based superalloy, both of which play the significant role on properties and performance. Neutron diffraction was employed to investigate the microstructural defects and residual stresses in a single crystal (SC) nickel-based superalloy, which was subjected to creeping under 220 MPa and 1000 °C for different times. The measured superlattice and fundamental lattice reflections confirm that the mismatch and tetragonal distortions with c/a > 1 exist in the SC superalloy. At the initially unstrained state, there exists the angular distortion between γ and γ' phases with small triaxial compressive stresses, ensuring the structural stability of the superalloy. After creeping, the tetragonal distortion for the γ phase is larger than that for the γ' phase. With increasing the creeping time, the mismatch between γ and γ' phases increases to the maximum, then decreases gradually and finally remains unchanged. The macroscopic residual stress shows a similar behavior with the mismatch, indicating the correlation between them. Based on the model of shear and dislocations, the evolution of microstructural defects and residual stress are reasonably explained. The effect of shear is dominant at the primary creep stage, which greatly enlarges the mismatch and the residual stress. The dislocations weaken the effect of shear for the further creep stage, resulting in the decrease of the mismatch and relaxation of the residual stress. Those findings add some helpful understanding into the microstructure-performance relationship in the SC nickel-based superalloy, which might provide the insight to materials design and applications.

  10. Border poetics

    Directory of Open Access Journals (Sweden)

    Liv Lundberg

    2014-07-01

    Full Text Available The language of poetry is a language of inquiry, not the language of a genre. Poetry has the capacity of entering those zones known as borderlands, where you meet strange things and foreign people. In this poetic world view, the border is not an edge along the fringe of lands, societies and experiences, but rather their very middle – and their in-between. The structures of language are social structures in which meanings and intentions are already in place, always fighting for power and dominance, with rhetorical figures and more violent weapons.

  11. High Frequency of a Single Nucleotide Substitution (c.-6-180T>G) of the Canine MDR1/ABCB1 Gene Associated with Phenobarbital-Resistant Idiopathic Epilepsy in Border Collie Dogs

    OpenAIRE

    Mizukami, Keijiro; Yabuki, Akira; Chang, Hye-Sook; Uddin, Mohammad Mejbah; Rahman, Mohammad Mahbubur; Kushida, Kazuya; Kohyama, Moeko; Yamato, Osamu

    2013-01-01

    A single nucleotide substitution (c.-6-180T>G) associated with resistance to phenobarbital therapy has been found in the canine MDR1/ABCB1 gene in Border Collies with idiopathic epilepsy. In the present study, a PCR-restriction fragment length polymorphism assay was developed for genotyping this mutation, and a genotyping survey was carried out in a population of 472 Border Collies in Japan to determine the current allele frequency. The survey demonstrated the frequencies of the T/T wild type...

  12. Residual strains and microstructure development in single and sequential double sided friction stir welds in RQT-701 steel

    Energy Technology Data Exchange (ETDEWEB)

    Barnes, S.J. [School of Materials, University of Manchester, Grosvenor Street, Manchester M1 7HS (United Kingdom)], E-mail: simon.barnes-2@manchester.ac.uk; Steuwer, A. [FaME38, ILL ESRF, 6 rue J.Horowitz, 38042 Grenoble, Cedex (France); University of Plymouth, Drake Circus, Plymouth PL4 8AA (United Kingdom); Mahawish, S. [School of Materials, University of Manchester, Grosvenor Street, Manchester M1 7HS (United Kingdom); Johnson, R. [TWI Yorkshire, Wallis Way, Catcliffe, Rotherham S60 5TZ (United Kingdom); Withers, P.J. [School of Materials, University of Manchester, Grosvenor Street, Manchester M1 7HS (United Kingdom)

    2008-09-25

    Single and double sided partial penetration friction stir butt welds, in a rolled, quenched and tempered steel (RQT-701), were produced at The Welding Institute (TWI) under controlled process conditions. The residual strain distributions in the longitudinal and transverse directions have been measured using energy dispersive synchrotron X-ray diffraction. The measured strains were indicative of longitudinal tensile residual stresses at levels greater than the 0.2% yield stress of the parent metal in both the single and double pass welds. In both cases, the maximum tensile strain was found in the parent metal at the boundary of the heat affected zone (HAZ). Microstructural analysis of the welds was carried out using optical microscopy and hardness variations were also mapped across the weld-plate cross-section. The maximum hardness was observed in the mixed bainite/martensite structure of the weld nugget on the advancing side of the stir zone. The minimum hardness was observed in the HAZ.

  13. Residual strains and microstructure development in single and sequential double sided friction stir welds in RQT-701 steel

    International Nuclear Information System (INIS)

    Barnes, S.J.; Steuwer, A.; Mahawish, S.; Johnson, R.; Withers, P.J.

    2008-01-01

    Single and double sided partial penetration friction stir butt welds, in a rolled, quenched and tempered steel (RQT-701), were produced at The Welding Institute (TWI) under controlled process conditions. The residual strain distributions in the longitudinal and transverse directions have been measured using energy dispersive synchrotron X-ray diffraction. The measured strains were indicative of longitudinal tensile residual stresses at levels greater than the 0.2% yield stress of the parent metal in both the single and double pass welds. In both cases, the maximum tensile strain was found in the parent metal at the boundary of the heat affected zone (HAZ). Microstructural analysis of the welds was carried out using optical microscopy and hardness variations were also mapped across the weld-plate cross-section. The maximum hardness was observed in the mixed bainite/martensite structure of the weld nugget on the advancing side of the stir zone. The minimum hardness was observed in the HAZ

  14. Detecting single-abasic residues within a DNA strand immobilized in a biological nanopore using an integrated CMOS sensor.

    Science.gov (United States)

    Kim, Jungsuk; Maitra, Raj D; Pedrotti, Ken; Dunbar, William B

    2013-02-01

    In this paper, we demonstrate the application of a novel current-measuring sensor (CMS) customized for nanopore applications. The low-noise CMS is fabricated in a 0.35μm CMOS process and is implemented in experiments involving DNA captured in an α-hemolysin (α-HL) nanopore. Specifically, the CMS is used to build a current amplitude map as a function of varying positions of a single-abasic residue within a homopolymer cytosine single-stranded DNA (ssDNA) that is captured and held in the pore. Each ssDNA is immobilized using a biotin-streptavidin linkage. Five different DNA templates are measured and compared: one all-cytosine ssDNA, and four with a single-abasic residue substitution that resides in or near the ~1.5nm aperture of the α-HL channel when the strand is immobilized. The CMOS CMS is shown to resolves the ~5Å displacements of the abasic residue within the varying templates. The demonstration represents an advance in application-specific circuitry that is optimized for small-footprint nanopore applications, including genomic sequencing.

  15. Characterization of Solids in Residual Wastes from Single-Shell Tanks at the Hanford Site, Washington, USA - 9277

    International Nuclear Information System (INIS)

    Krupka, Kenneth M.; Cantrell, Kirk J.; Schaef, Herbert T.; Arey, Bruce W.; Heald, Steve M.; Deutsch, William J.; Lindberg, Michael J.

    2009-01-01

    Solid-phase characterization methods have been used in an ongoing study of residual wastes (i.e., waste remaining after final retrieval operations) from the underground single-shell storage tanks 241-C-103, 241-C-106, 241-C-202, 241-C-203, and 241-S-112 at the U.S. Department of Energy's Hanford Site in Washington State. The results of studies completed to date show significant variability in the compositions of those residual wastes and the compositions, morphologies, and crystallinities of the individual phases that make up these wastes. These differences undoubtedly result from the various waste types stored and transferred in and out each tank and the sluicing and retrieval operations used for waste retrieval. Our studies indicate that these residual wastes are chemically-complex assemblages of crystalline and amorphous solids that contain contaminants as discrete phases and/or co-precipitated within oxide phases. Depending on the specific tank, various solids (e.g., gibbsite; boehmite; dawsonite; cancrinite; Fe oxides such as hematite, goethite, and maghemite; rhodochrosite; lindbergite; whewellite; nitratine; and numerous amorphous or poorly crystalline phases) have been identified by X-ray diffraction and scanning electron microscopy/energy dispersive X-ray spectroscopy in residual wastes studied to date. Our studies also show that contact of residual wastes with Ca(OH)2- and CaCO3-saturated aqueous solutions, which were used as surrogates for the compositions of pore-fluid leachants derived from young and aged cements respectively, may alter the compositions of solid phases present in the contacted wastes. Fe oxides/hydroxides have been identified in all residual wastes studied to date. They occur in these wastes as discrete particles, particles intergrown within a matrix of other phases, and surface coatings on other particles or particle aggregates. These Fe oxides/hydroxides typically contain trace concentrations of other transition metals, such Cr, Mn

  16. A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles

    Science.gov (United States)

    2016-09-07

    VH-2) is resistant to infection in an NPC1-36   dependent manner . We found that VH-2 cells are resistant to EBOV infection because the Rus-37...infection in a host species-dependent manner (24). Here, we demonstrate that an adjacent 89   residue, 503, highly conserved in the domain C of NPC1...Tyr sequence 194   change at residue 503 might influence EBOV GPCL–NPC1 binding in a bidirectional manner . 195   Accordingly, we expressed and

  17. Border installations

    International Nuclear Information System (INIS)

    Lenaerts, K.

    1988-01-01

    This chapter highlights the legal problems raised by the concept of a border installation. Using the Cattenom nuclear power plant as an example, the author describes the different stages of the legal conflict raised by construction of the plant and analyses the relationship between French administrative law and some provisions of the Euratom Treaty. Based on the Treaty, the Community institutions have adopted directives to strengthen inter-State co-operation and consultation between neighbouring countries. He observes that these principles of co-operation, consultation and vigilance already exist in public international law; however, international case law has not yet made it possible to establish the strict liability of the constructing state in case of a nuclear accident (NEA) [fr

  18. Modification of a single tryptophan residue in human Cu,Zn-superoxide dismutase by peroxynitrite in the presence of bicarbonate.

    Science.gov (United States)

    Yamakura, F; Matsumoto, T; Fujimura, T; Taka, H; Murayama, K; Imai, T; Uchida, K

    2001-07-09

    Human recombinant Cu,Zn-SOD was reacted with peroxynitrite in a reaction mixture containing 150 mM potassium phosphate buffer (pH 7.4) 25 mM sodium bicarbonate, and 0.1 mM diethylenetriamine pentaacetic acid. Disappearance of fluorescence emission at 350 nm, which could be attributed to modification of a single tryptophan residue, was observed in the modified enzyme with a pH optimum of around 8.4. A fluorescence decrease with the same pH optimum was also observed without sodium bicarbonate, but with less efficiency. Amino acid contents of the modified enzyme showed no significant difference in all amino acids except the loss of a single tryptophan residue of the enzyme. The peroxynitrite-modified enzyme showed an increase in optical absorption around 350 nm and 30% reduced enzyme activity based on the copper contents. The modified enzyme showed the same electron paramagnetic resonance spectrum as that of the control enzyme. The modified Cu,Zn-SOD showed a single protein band in sodium dodecyl sulfate--polyacrylamide gel electrophoresis (SDS--PAGE) and five protein bands in non-denaturing PAGE. From this evidence, we conclude that nitration and/or oxidation of the single tryptophan 32 and partial inactivation of the enzyme activity of Cu,Zn-SOD is caused by a peroxynitrite-carbon dioxide adduct without perturbation of the active site copper integrity.

  19. Single particle measurements of the chemical composition of cirrus ice residue during CRYSTAL-FACE

    Science.gov (United States)

    Cziczo, D. J.; Murphy, D. M.; Hudson, P. K.; Thomson, D. S.

    2004-02-01

    The first real-time, in situ, investigation of the chemical composition of the residue of cirrus ice crystals was performed during July 2002. This study was undertaken on a NASA WB-57F high-altitude research aircraft as part of CRYSTAL-FACE, a field campaign which sought to further our understanding of the relation of clouds, water vapor, and climate by characterizing, among other parameters, anvil cirrus formed about the Florida peninsula. A counter flow virtual impactor (CVI) was used to separate cirrus ice from the unactivated interstitial aerosol particles and evaporate condensed-phase water. Residual material, on a crystal-by-crystal basis, was subsequently analyzed using the NOAA Aeronomy Laboratory's Particle Analysis by Laser Mass Spectrometry (PALMS) instrument. Sampling was performed from 5 to 15 km altitude and from 12° to 28° north latitude within cirrus originating over land and ocean. Chemical composition measurements provided several important results. Sea salt was often incorporated into cirrus, consistent with homogeneous ice formation by aerosol particles from the marine boundary layer. Size measurements showed that large particles preferentially froze over smaller ones. Meteoritic material was found within ice crystals, indicative of a relation between stratospheric aerosol particles and tropospheric clouds. Mineral dust was the dominant residue observed in clouds formed during a dust transport event from the Sahara, consistent with a heterogeneous freezing mechanism. These results show that chemical composition and size are important determinants of which aerosol particles form cirrus ice crystals.

  20. Construction of a recombinant single chain antibody recognizing nonreducing terminal mannose residues applicable to immunohistochemistry.

    Science.gov (United States)

    Yuasa, Noriyuki; Iida, Noriko; Sakaue, Hiroyuki; Zhang, Wei; Wilczynski, Sharon; Fujita-Yamaguchi, Yoko

    2007-10-01

    We recently reported characterization of 25 clones isolated from a phage library displaying human scFvs using a neoglycolipid Man3-DPPE, which was synthesized from mannotriose (Man3) and dipalmitoylphosphatidylethanolamine (DPPE). Of those, 5A3 scFv was successfully expressed and purified as a humanized scFv-Fc form (Sakai et al., Biochemistry 46:253, 2007, Zhang et al. ibid 263). To carry out immunohistochemistry (IHC) in human tissues, a HA tag sequence was introduced to the 5A3 scFv-Fc gene and the resulting construct was transfected to murine myeloma NS0 cells. The 5A3 scFv-Fc protein expressed was affinity-purified. Sodium dodecyl sulfate polyacrylamide gel electrophoresis under nonreducing and reducing conditions and enzyme-linked immunosorbent assay confirmed that 5A3 scFv-Fc protein is dimeric and retained the ability to recognize nonreducing terminal mannose residues. IHC staining of non-neoplastic tissues by this recombinant antibody revealed that no immunoreactivity was detectable in most of 16 tissues examined. Exceptions were found in IHC staining of kidney and pancreas, which demonstrated clear staining of proximal tubules and islet of Langerhans, respectively. These results demonstrated that nonreducing terminal mannose residues are not usually present under normal physiological conditions. This study thus provided a potentially useful tool for examination of the nonreducing terminal mannose residues, which may become exposed under certain pathophysiologycal conditions.

  1. Single-Residue Sensitivity in Neutron Reflectivity and Resonant X-ray Reflectivity from Langmuir Monolayers of Synthetic Peptides

    Science.gov (United States)

    Strzalka, Joseph; Satija, Sushil; Dimasi, Elaine; Kuzmenko, Ivan; Gog, Thomas; Blasie, J. Kent

    2004-03-01

    Labeling groups with ^2H to distinguish them in the scattering length density (SLD) profile constitutes the chief advantage of neutron reflectivity (NR) in studying Langmuir monolayers (LM) of lipids and proteins. Solid phase synthesis (SPPS) permits the labeling of a single residue in a peptide. Recent work demonstrates the sensitivity of NR to single ^2H-labeled residues in LM of vectorially oriented α -helical bundle peptides. NR requires comparison of isomorphic samples of all-^1H and ^2H-labeled peptides. Alternately, resonant x-ray reflectivity (RXR) uses only one sample. RXR exploits energy-dependent changes in the scattering factor from heavy atoms to distinguish them within the SLD profile. Peptides may be labeled by SPPS (e.g. Br-Phe), or may have inherent labels (e.g. Fe in heme proteins). As test cases, we studied LM of Br-labeled lipids and peptides with RXR. Both approaches require a model-independent means of obtaining SLD profiles from the reflectivity data. We have applied box-refinement to obtain the gradient SLD profile. This is fit uniquely with a sum of Gaussians and integrated analytically [Blasie et al., PRB 67 224201 (2003)] to provide the SLD profile. Label positions can then be determined to sub-Ångstrom accuracy. This work supported by the NIH (GM55876).

  2. Assessment of single-shell tank residual-liquid issues at Hanford Site, Washington

    International Nuclear Information System (INIS)

    Murthy, K.S.; Stout, L.A.; Napier, B.A.; Reisenauer, A.E.; Landstrom, D.K.

    1983-06-01

    This report provides an assessment of the overall effectiveness and implications of jet pumping the interstitial liquids (IL) from single-shell tanks at Hanford. The jet-pumping program, currently in progress at Hanford, involves the planned removal of IL contained in 89 of the 149 single-shell tanks and its transfer to double-shell tanks after volume reduction by evaporation. The purpose of this report is to estimate the public and worker doses associated with (1) terminating pumping immediately, (2) pumping to a 100,000-gal limit per tank, (3) pumping to a 50,000-gal limit per tank, and (4) pumping to the maximum practical liquid removal level of 30,000 gal. Assessment of the cost-effectiveness of these various levels of pumping in minimizing any undue health and safety risks to the public or worker is also presented

  3. Allergy medication in Japanese volunteers: treatment effect of single doses on nocturnal sleep architecture and next day residual effects.

    Science.gov (United States)

    Boyle, Julia; Eriksson, Malin; Stanley, Neil; Fujita, Tomoe; Kumagi, Yuji

    2006-07-01

    To evaluate the acute effects of two histamine H(1)-receptor antagonists on nocturnal sleep architecture and on next day cognitive function and psychomotor performance. This was a single-site, randomized, double-blind, 3-way crossover study, comparing the effects of a single dose of chlorpheniramine (6 mg), fexofenadine (120 mg) and placebo in 18 healthy (male and female) Japanese volunteers aged 20-55 years. Volunteers were resident for 3 days and each period was separated by a minimum 5-day washout period. The three treatments were administered at 23.00 h. Overnight sleep was measured from 23.00 h to 07.00 h using polysomnography. Residual effects were studied at 07.00 h and 9.00 h the next morning, with the latency to sleep (sleep latency test) measured at 09.30 h. Compared with placebo, chlorpheniramine increased the latencies to sleep onset and rapid eye movement (REM) sleep (p < or = 0.05 for both), and reduced the duration of REM sleep (p residual effects the next morning were concerned there were decrements in performance with chlorpheniramine, but not with fexofenadine. Chlorpheniramine 6 mg impaired divided attention (p < 0.001), vigilance (p < 0.05), working memory (p < 0.0001) and sensori-motor performance (p < 0.01), and the latency to daytime sleep was reduced (p < 0.0001). Six adverse events possibly related to study medication were reported during the study, three of which were related to placebo, two to fexofenadine and one to chlorpheniramine. These findings suggest that a single nocturnal dose of fexofenadine has advantages over the first-generation antihistamine chlorpheniramine, being free of disruption of night-time sleep and detrimental effects on cognitive performance the next day. It is likely that this advantage will remain with chronic ingestion, but this would need to be confirmed.

  4. "Ico-Alone" single nocturnal exchange to initiate peritoneal dialysis in patients with residual renal function-Five year, single centre experience

    Directory of Open Access Journals (Sweden)

    T Jeloka

    2013-01-01

    Full Text Available We analyzed the outcome of incremental dialysis with single nocturnal icodextrin exchange peritoneal dialysis (PD as the initial treatment for end-stage kidney failure in patients who have significant residual renal function. All adult patients opting for PD as renal replacement therapy, having residual renal function, and urinary KT/V of 1.0 were offered incremental dialysis with single nocturnal icodextrin exchange as initial treatment. Adequacy of dialysis was calculated at 1, 3, and 6 months and then 6 monthly. Patients were shifted to conventional PD if short of adequacy or if clinically indicated. Median period on "Ico-alone," peritonitis, exit site infection rates, and patient survival, while on this protocol, were calculated. These outcomes were compared with the cohort of contemporary patients on conventional PD. Thirteen patients were initiated on "Ico-alone" dialysis between October 2006 and October 2011. The baseline characteristics were similar when compared with cohort of conventional PD patients, except urine volume, which was more in "Ico-alone" group (1265 ± 316 vs. 551 ± 504, P = 0.000. Total KT/V at 3 months (1.63 ± 0.6 vs. 1.7 ± 0.2, P = 0.6 and at 1 year (1.64 ± 0.5 vs. 1.53 ± 0.3, P = 0.6 was similar to the cohort of conventional PD patients. Median period on "Ico-alone" was 9.6 months. Peritonitis rate was 1 episode in 56.22 vs 25.29 patient-months and exit site infection was 1 episode in 56.2 vs 189.71 patient-months in "Ico-alone" and conventional group, respectively. Patient survival was 42.84 months in "Ico-alone′ vs 25.29 months in conventional dialysis ( P = 0.01. In conclusion, single icodextrin exchange offers adequate dialysis in patients with residual renal function (KT/V = 1 for a median period of 9 months.

  5. Simulation investigation of thermal phase transformation and residual stress in single pulse EDM of Ti-6Al-4V

    Science.gov (United States)

    Tang, Jiajing; Yang, Xiaodong

    2018-04-01

    The thermal phase transformation and residual stress are ineluctable in the electrical discharge machining (EDM) process, and they will greatly affect the working performances of the machined surface. This paper presents a simulation study on the thermal phase transformation and residual stress in single-pulse EDM of Ti-6Al-4V, which is the most popular titanium alloy in fields such as aircraft engine and some other leading industries. A multi-physics model including thermal, hydraulic, metallography and structural mechanics was developed. Based on the proposed model, the thickness and metallographic structure of the recast layer and heat affected layer (HAZ) were investigated. The distribution and characteristics of residual stress around the discharge crater were obtained. The recast layer and HAZ at the center of crater are found to be the thinnest, and their thicknesses gradually increase approaching the periphery of the crater. The recast layer undergoes a complete α‧ (martensitic) transformation, while the HAZ is mainly composed by the α  +  β  +  α‧ three-phase microstructure. Along the depth direction of crater, the Von Mises stress increases first and then decreases, reaching its maximal value near the interface of recast layer and HAZ. In the recast layer, both compressive stress component and tensile stress component are observed. ANOVA results showed that the influence of discharge current on maximal tensile stress is more significant than that of pulse duration, while the pulse duration has more significant influence on average thickness of the recast layer and the depth location of the maximal tensile stress. The works conducted in this study will help to evaluate the quality and integrity of EDMed surface, especially when the non-destructive testing is difficult to achieve.

  6. A residual-based a posteriori error estimator for single-phase Darcy flow in fractured porous media

    KAUST Repository

    Chen, Huangxin

    2016-12-09

    In this paper we develop an a posteriori error estimator for a mixed finite element method for single-phase Darcy flow in a two-dimensional fractured porous media. The discrete fracture model is applied to model the fractures by one-dimensional fractures in a two-dimensional domain. We consider Raviart–Thomas mixed finite element method for the approximation of the coupled Darcy flows in the fractures and the surrounding porous media. We derive a robust residual-based a posteriori error estimator for the problem with non-intersecting fractures. The reliability and efficiency of the a posteriori error estimator are established for the error measured in an energy norm. Numerical results verifying the robustness of the proposed a posteriori error estimator are given. Moreover, our numerical results indicate that the a posteriori error estimator also works well for the problem with intersecting fractures.

  7. Contaminant Release from Residual Waste in Closed Single-Shell Tanks and Other Waste Forms Associated with the Tanks

    International Nuclear Information System (INIS)

    Deutsch, William J.

    2008-01-01

    This chapter describes the release of contaminants from the various waste forms that are anticipated to be associated with closure of the single-shell tanks. These waste forms include residual sludge or saltcake that will remain in the tanks after waste retrieval. Other waste forms include engineered glass and cementitious materials as well as contaminated soil impacted by previous tank leaks. This chapter also describes laboratory testing to quantify contaminant release and how the release data are used in performance/risk assessments for the tank waste management units and the onsite waste disposal facilities. The chapter ends with a discussion of the surprises and lessons learned to date from the testing of waste materials and the development of contaminant release models

  8. Border information flow architecture

    Science.gov (United States)

    2006-04-01

    This brochure describes the Border Information Flow Architecture (BIFA). The Transportation Border Working Group, a bi-national group that works to enhance coordination and planning between the United States and Canada, identified collaboration on th...

  9. A single gp120 residue can affect HIV-1 tropism in macaques.

    Directory of Open Access Journals (Sweden)

    Gregory Q Del Prete

    2017-09-01

    Full Text Available Species-dependent variation in proteins that aid or limit virus replication determines the ability of lentiviruses to jump between host species. Identifying and overcoming these differences facilitates the development of animal models for HIV-1, including models based on chimeric SIVs that express HIV-1 envelope (Env glycoproteins, (SHIVs and simian-tropic HIV-1 (stHIV strains. Here, we demonstrate that the inherently poor ability of most HIV-1 Env proteins to use macaque CD4 as a receptor is improved during adaptation by virus passage in macaques. We identify a single amino acid, A281, in HIV-1 Env that consistently changes during adaptation in macaques and affects the ability of HIV-1 Env to use macaque CD4. Importantly, mutations at A281 do not markedly affect HIV-1 Env neutralization properties. Our findings should facilitate the design of HIV-1 Env proteins for use in non-human primate models and thus expedite the development of clinically relevant reagents for testing interventions against HIV-1.

  10. The Border Multiple

    DEFF Research Database (Denmark)

    of European borders by looking at border practices in the light of the mobility turn, and thus as dynamic, multiple, diverse and best expressed in everyday experiences of people living at and with borders, rather than focusing on static territorial divisions between states and regions at geopolitical level...

  11. The Border Multiple

    DEFF Research Database (Denmark)

    Addressing and conceptualizing the changing character of borders in contemporary Europe, this book examines developments occurring in the light of European integration processes and an on-going tightening of Europe's external borders. Moreover, the book suggests new ways of investigating the nature...... of European borders by looking at border practices in the light of the mobility turn, and thus as dynamic, multiple, diverse and best expressed in everyday experiences of people living at and with borders, rather than focusing on static territorial divisions between states and regions at geopolitical level...

  12. Conformation-specific spectroscopy of capped glutamine-containing peptides: role of a single glutamine residue on peptide backbone preferences.

    Science.gov (United States)

    Walsh, Patrick S; Dean, Jacob C; McBurney, Carl; Kang, Hyuk; Gellman, Samuel H; Zwier, Timothy S

    2016-04-28

    The conformational preferences of a series of short, aromatic-capped, glutamine-containing peptides have been studied under jet-cooled conditions in the gas phase. This work seeks a bottom-up understanding of the role played by glutamine residues in directing peptide structures that lead to neurodegenerative diseases. Resonant ion-dip infrared (RIDIR) spectroscopy is used to record single-conformation infrared spectra in the NH stretch, amide I and amide II regions. Comparison of the experimental spectra with the predictions of calculations carried out at the DFT M05-2X/6-31+G(d) level of theory lead to firm assignments for the H-bonding architectures of a total of eight conformers of four molecules, including three in Z-Gln-OH, one in Z-Gln-NHMe, three in Ac-Gln-NHBn, and one in Ac-Ala-Gln-NHBn. The Gln side chain engages actively in forming H-bonds with nearest-neighbor amide groups, forming C8 H-bonds to the C-terminal side, C9 H-bonds to the N-terminal side, and an amide-stacked geometry, all with an extended (C5) peptide backbone about the Gln residue. The Gln side chain also stabilizes an inverse γ-turn in the peptide backbone by forming a pair of H-bonds that bridge the γ-turn and stabilize it. Finally, the entire conformer population of Ac-Ala-Gln-NHBn is funneled into a single structure that incorporates the peptide backbone in a type I β-turn, stabilized by the Gln side chain forming a C7 H-bond to the central amide group in the β-turn not otherwise involved in a hydrogen bond. This β-turn backbone structure is nearly identical to that observed in a series of X-(AQ)-Y β-turns in the protein data bank, demonstrating that the gas-phase structure is robust to perturbations imposed by the crystalline protein environment.

  13. Evolution and function of the Mycoplasma hyopneumoniae peroxiredoxin, a 2-Cys-like enzyme with a single Cys residue.

    Science.gov (United States)

    Gonchoroski, Taylor; Virginio, Veridiana G; Thompson, Claudia E; Paes, Jéssica A; Machado, Cláudio X; Ferreira, Henrique B

    2017-04-01

    The minimal genome of the mollicute Mycoplasma hyopneumoniae, the etiological agent of porcine enzootic pneumonia, encodes a limited repertoire of antioxidant enzymes that include a single and atypical peroxiredoxin (MhPrx), whose evolution and function were studied here. MhPrx has only one catalytic cysteine, in contrast with some of its possible ancestors (2-Cys peroxiredoxins), which have two. Although it is more similar to 2-Cys orthologs, MhPrx can still function with a single peroxidatic cysteine (Cys P ), using non-thiolic electron donors to reduce it. Therefore, MhPrx could be a representative of a possible group of 2-Cys peroxiredoxins, which have lost the resolving cysteine (Cys R ) residue without losing their catalytic properties. To further investigate MhPrx evolution, we performed a comprehensive phylogenetic analysis in the context of several bacterial families, including Prxs belonging to Tpx and AhpE families, shedding light on the evolutionary history of Mycoplasmataceae Prxs and giving support to the hypothesis of a relatively recent loss of the Cys R within this family. Moreover, mutational analyses provided insights into MhPrx function with one, two, or without catalytic cysteines. While removal of the MhPrx putative Cys P caused complete activity loss, confirming its catalytic role, the introduction of a second cysteine in a site correspondent to that of the Cys R of a 2-Cys orthologue, as in the MhPrx supposed ancestral form, was compatible with enzyme activity. Overall, our phylogenetic and mutational studies support that MhPrx recently diverged from a 2-Cys Prx ancestor and pave the way for future studies addressing structural, functional, and evolutive aspects of peroxiredoxin subfamilies in Mollicutes and other bacteria.

  14. Control of peptide nanotube diameter by chemical modifications of an aromatic residue involved in a single close contact

    Science.gov (United States)

    Tarabout, Christophe; Roux, Stéphane; Gobeaux, Frédéric; Fay, Nicolas; Pouget, Emilie; Meriadec, Cristelle; Ligeti, Melinda; Thomas, Daniel; IJsselstijn, Maarten; Besselievre, François; Buisson, David-Alexandre; Verbavatz, Jean-Marc; Petitjean, Michel; Valéry, Céline; Perrin, Lionel; Rousseau, Bernard; Artzner, Franck; Paternostre, Maité; Cintrat, Jean-Christophe

    2011-01-01

    Supramolecular self-assembly is an attractive pathway for bottom-up synthesis of novel nanomaterials. In particular, this approach allows the spontaneous formation of structures of well-defined shapes and monodisperse characteristic sizes. Because nanotechnology mainly relies on size-dependent physical phenomena, the control of monodispersity is required, but the possibility of tuning the size is also essential. For self-assembling systems, shape, size, and monodispersity are mainly settled by the chemical structure of the building block. Attempts to change the size notably by chemical modification usually end up with the loss of self-assembly. Here, we generated a library of 17 peptides forming nanotubes of monodisperse diameter ranging from 10 to 36 nm. A structural model taking into account close contacts explains how a modification of a few Å of a single aromatic residue induces a fourfold increase in nanotube diameter. The application of such a strategy is demonstrated by the formation of silica nanotubes of various diameters. PMID:21518895

  15. Characterization of an endoprotease from rat small intestinal mucosal secretory granules which generates somatostatin-28 from prosomatostatin by cleavage after a single arginine residue

    NARCIS (Netherlands)

    Beinfeld, M. C.; Bourdais, J.; Kuks, P.; Morel, A.; Cohen, P.

    1989-01-01

    We have extracted, characterized, and partially purified an enzyme from secretory granules from rat small intestinal mucosa which cleaves a synthetic prosomatostatin substrate on the carboxyl side of a single arginine residue. This substrate Leu-Gln-Arg-Ser-Ala-Asn-Ser-NH2 contains the monobasic

  16. Border Crossings, US-Mexico Border, 2010, NAVTEQ

    Data.gov (United States)

    U.S. Environmental Protection Agency — NAVTEQ Border Crossings for Region 9. The Border Crossing layer contains all international border crossings for all motorway crossings, as well as other important...

  17. Border Crossing Points, US-Mexico Border, 2015, NAVTEQ

    Data.gov (United States)

    U.S. Environmental Protection Agency — NAVTEQ Border Crossings for the United States. The Border Crossing layer contains all international border crossings for all motorway crossings, as well as other...

  18. Straddling the border

    DEFF Research Database (Denmark)

    Eilenberg, Michael

    2011-01-01

    border between the Indonesian province of West Kalimantan and the Malaysian state of Sarawak on the island of Borneo. Based on local narratives, the aim of this paper is to unravel the little known history of how the Iban segment of the border population in West Kalimantan became entangled in the highly...

  19. The Border Pedagogy Revisited

    Science.gov (United States)

    Kazanjian, Christopher John

    2011-01-01

    Border pedagogy is a multicultural educational approach utilized in multicultural settings to help students understand their histories and experiences and how it affects their identities and cultures. The approach seeks to produce intellectuals that transcend physical and metaphysical boundaries. The goal of border pedagogy is to remove cultural…

  20. Business, brokers and borders

    DEFF Research Database (Denmark)

    Walther, Olivier

    Using social network analysis, this paper studies the structure of trade networks that developed across West African borders. The first part aims to understand the centralization of cross-border trade networks. In a business environment where transaction costs are extremely high, we find...... developed with foreign partners from a different origin, religion or culture. In the second part, we study the spatial structure of trade networks and the influence of national borders on the development of social ties. The paper shows that the spatial form of trade networks is constrained by the historical...... origin of the traders engaged in cross-border activities. In those markets where trade is recent and where most of the traders are not native of the region, national borders are likely to exert a greater influence than in those regions where trade has pre-colonial roots....

  1. Why Border Enforcement Backfired.

    Science.gov (United States)

    Massey, Douglas S; Durand, Jorge; Pren, Karen A

    2016-03-01

    In this article we undertake a systematic analysis of why border enforcement backfired as a strategy of immigration control in the United States. We argue theoretically that border enforcement emerged as a policy response to a moral panic about the perceived threat of Latino immigration to the United States propounded by self-interested bureaucrats, politicians, and pundits who sought to mobilize political and material resources for their own benefit. The end result was a self-perpetuating cycle of rising enforcement and increased apprehensions that resulted in the militarization of the border in a way that was disconnected from the actual size of the undocumented flow. Using an instrumental variable approach, we show how border militarization affected the behavior of unauthorized migrants and border outcomes to transform undocumented Mexican migration from a circular flow of male workers going to three states into an eleven-million person population of settled families living in 50 states.

  2. Changing European borders: from separation to interface? An introduction

    Directory of Open Access Journals (Sweden)

    Jen Nelles

    2011-03-01

    Full Text Available The aim of this special issue is to address the evolution of European borders from a comparative perspective. This collection of papers spans a wide variety of topics in the realm of borderland studies. Although each engages with a single empirical or theoretical case collectively they identify nuances relevant to the theoretical elaboration of borders, and particularly contribute to the field of sub-national cross-border cooperation. In the course of its analysis each paper contributes to a broader understanding of the definition of cross-border regions; identifies a set of barriers to cooperation in these contexts; explores the role of identities on cooperation and of the role of borders in constructing those identities; and reflects on the socio-political meanings and uses of these international boundaries. This introduction discusses theoretical significance of these contributions to major debates in the study of borders and border regions.

  3. Comparison between total lung capacity and residual volume values obtained by pletysmography and single breath methods with methane

    Directory of Open Access Journals (Sweden)

    Ricardo Marques Dias

    2006-11-01

    Full Text Available We analyzed pulmonary function tests of twenty asthmatic patients from Gaffrée e Guinle University Hospital, classified according to Brazilian Guidelines for Asthma (2002, similar to GINA, into mild persistent or moderate (9 or severe (11 asthma. We obtained parameters from spirometry, plethysmograph(PL and single breath technique for diffusion capacity (SB, with methane. Total lung capacity and residual volume were called TLCPL and RVPL when measured by pletysmography and TLCSB and RVSB when determined by single breath test. There were 13 women and 7 men with mean age of 47.6 years. The pulmonary dysfunction degree to FEV1/FVC was 58.8% with CI95=53.9 to 63.6. The mean values in litres for TLCPL (5.94 and RVPL (2.55 were significantly higher than for TLCSB (4.73 and RVSB (1.66. Multiple regression equations were determined for TLCPL e RVPL using only single breath values, TLCSB or RVSB, and spirographic parameters, with significant regression coefficients. However, the inclusion of spirometric parameters, except for FVC, did not improve the predicted capacity for the equations. Considering only the TLCSB, r2=0.79, the equation is: TLCPL=(TLCSB*1.025+1.088, with EPE=0.64. The regression for RVPL, r2=0.23, is: RVPL=(RVSB*0.9268+1.012. The results obtained after bronchodilation with 400 mcg of salbutamol did not improve the regression. We concluded that the SB technique did not obtain the same results as pletysmography for TLC and RV, but for TLC this difference can be predicted. Resumo: Foram analisados exames de função pulmonar de 20 asmáticos, em acompanhamento no HU Gaffrée Guinle, classificados, segundo o Consenso Brasileiro (2002, em asma leve persistente ou moderada (9 e grave (11. Foram obtidos os valores dos parâmetros da espirografia, da pletismografia e da técnica de respiração única, com metano, para a medida da difusão pulmonar (DLco. Assim, a capacidade pulmonar total e o volume residual, quando

  4. Single particle analysis of ice crystal residuals observed in orographic wave clouds over Scandinavia during INTACC experiment

    Directory of Open Access Journals (Sweden)

    A. C. Targino

    2006-01-01

    Full Text Available Individual ice crystal residual particles collected over Scandinavia during the INTACC (INTeraction of Aerosol and Cold Clouds experiment in October 1999 were analyzed by Scanning Electron Microscopy (SEM equipped with Energy-Dispersive X-ray Analysis (EDX. Samples were collected onboard the British Met Office Hercules C-130 aircraft using a Counterflow Virtual Impactor (CVI. This study is based on six samples collected in orographic clouds. The main aim of this study is to characterize cloud residual elemental composition in conditions affected by different airmasses. In total 609 particles larger than 0.1 μm diameter were analyzed and their elemental composition and morphology were determined. Thereafter a hierarchical cluster analysis was performed on the signal detected with SEM-EDX in order to identify the major particle classes and their abundance. A cluster containing mineral dust, represented by aluminosilicates, Fe-rich and Si-rich particles, was the dominating class of particles, accounting for about 57.5% of the particles analyzed, followed by low-Z particles, 23.3% (presumably organic material and sea salt (6.7%. Sulfur was detected often across all groups, indicating ageing and in-cloud processing of particles. A detailed inspection of samples individually unveiled a relationship between ice crystal residual composition and airmass origin. Cloud residual samples from clean airmasses (that is, trajectories confined to the Atlantic and Arctic Oceans and/or with source altitude in the free troposphere were dominated primarily by low-Z and sea salt particles, while continentally-influenced airmasses (with trajectories that originated or traveled over continental areas and with source altitude in the continental boundary layer contained mainly mineral dust residuals. Comparison of residual composition for similar cloud ambient temperatures around –27°C revealed that supercooled clouds are more likely to persist in conditions where

  5. Border Crossing Entry Data

    Data.gov (United States)

    Department of Transportation — The Bureau of Transportation Statistics (BTS) Border Crossing/Entry Data provides summary statistics for inbound crossings at the U.S.-Canadian and the U.S.-Mexican...

  6. Border of spacetime

    International Nuclear Information System (INIS)

    Harada, Tomohiro; Nakao, Ken-ichi

    2004-01-01

    It is still uncertain whether the cosmic censorship conjecture is true or not. To get a new insight into this issue, we propose the concept of the border of spacetime as a generalization of the spacetime singularity and discuss its visibility. The visible border, corresponding to the naked singularity, is not only relevant to mathematical completeness of general relativity but also a window into new physics in strongly curved spacetimes, which is in principle observable

  7. Border effects without borders: What divides Japan's internal trade?

    OpenAIRE

    Wrona, Jens

    2015-01-01

    Over the last 20 years the trade literature repeatedly documented the trade-reducing effects of inter- and intra-national borders. Thereby, the puzzling size and persistence of observed border effects from the beginning raised doubts on the role of underlying political borders. However, when observed border effects are not caused by political trade barriers, why should their spatial dimension then inevitably coincide with the geography of present or past political borders? This paper identifi...

  8. Leaching of APC residues from secondary Pb metallurgy using single extraction tests: the mineralogical and the geochemical approach.

    Science.gov (United States)

    Ettler, Vojtech; Mihaljevic, Martin; Sebek, Ondrej; Strnad, Ladislav

    2005-05-20

    Two air-pollution-control (APC) residues--one from flue gas cooling with alkaline water and one from deionized water cooling--from secondary lead metallurgy were submitted to two different standardized short-term leaching protocols: US EPA toxicity characteristic leaching procedure (TCLP) and static leaching according to Czech/European norm EN 12457-2. The experimental procedure was coupled with detailed mineralogical investigation of the solid material (SEM, XRPD) and speciation-solubility calculations using the PHREEQC-2 geochemical code. Both types of residues were considered as hazardous materials exhibiting substantial leaching of Pb (up to 7130 mg/l) and other inorganic contaminants. However, the APC residue produced by flue gas cooling with alkaline water (sample B) exhibits more favourable leaching and environmental characteristics than that produced by simple deionised water cooling (sample A). At pH 6, phosgenite (PbCl2.PbCO3) became the dominant secondary phase. The results are consistent with the mineralogical and geochemical studies focused on acidic forest soils highly polluted by smelter emissions, where anglesite, as a unique Pb-bearing phase, has been detected. From the technological point of view, the mixing of APC residue with alkaline water, followed by an increase in the suspension pH and equilibration with atmospheric CO2, may be used to ensure the precipitation of less soluble Pb carbonates, which are more easily recycled in the Pb recovery process in the metallurgical plant.

  9. A single arginine residue is required for the interaction of the electron transferring flavoprotein (ETF) with three of its dehydrogenase partners.

    Science.gov (United States)

    Parker, Antony R

    2003-12-01

    The interaction of several dehydrogenases with the electron transferring flavoprotein (ETF) is a crucial step required for the successful transfer of electrons into the electron transport chain. The exact determinants regarding the interaction of ETF with its dehydrogenase partners are still unknown. Chemical modification of ETF with arginine-specific reagents resulted in the loss, to varying degrees, of activity with medium chain acyl-coenzyme A dehydrogenase (MCAD). The kinetic profiles showed the inactivations followed pseudo-first-order kinetics for all reagents used. For activity with MCAD, maximum inactivation of ETF was accomplished by 2,3-butanedione (4% residual activity after 120 min) and it was shown that modification of one arginine residue was responsible for the inactivation. Almost 100% restoration of this ETF activity was achieved upon incubation with free arginine. However, the same 2,3-butanedione modified ETF only possessed decreased activity with dimethylglycine-(DMGDH, 44%) and sarcosine- (SDH, 27%) dehydrogenases unlike the abolition with MCAD. Full protection of ETF from arginine modification by 2,3-butanedione was achieved using substrate-protected DMGDH, MCAD and SDH respectively. Cross-protection studies of ETF with the three dehydrogenases implied use of the same single arginine residue in the binding of all three dehydrogenases. These results lead us to conclude that this single arginine residue is essential in the binding of the ETF to MCAD, but only contributes partially to the binding of ETF to SDH and DMGDH and thus, the determinants of the dehydrogenase binding sites overlap but are not identical.

  10. Border region studies

    DEFF Research Database (Denmark)

    Makkonen, Teemu; Williams, Allan

    2016-01-01

    The contemporary conditions of academic capitalism exert pressures on researchers to avoid ‘peripheral’ journals and ‘unfashionable’ topics. Here an attempt is made to shed light onto the structure of one such ‘offbeat’ field, namely ‘border region studies’, by discussing its geographical...... distribution, key themes, significance and impact. The review suggests that border region studies can be considered a significant and important ‘branch’ of regional studies, which accounts for a small but increasing proportion of regional studies research particularly in Europe and North America. Four main...

  11. From Borders to Margins

    DEFF Research Database (Denmark)

    Parker, Noel

    2009-01-01

    of entities that are ever open to identity shifts.  The concept of the margin possesses a much wider reach than borders, and focuses continual attention on the meetings and interactions between a range of indeterminate entities whose interactions may determine both themselves and the types of entity...... upon Deleuze's philosophy to set out an ontology in which the continual reformulation of entities in play in ‘post-international' society can be grasped.  This entails a strategic shift from speaking about the ‘borders' between sovereign states to referring instead to the ‘margins' between a plethora...

  12. Errors in Computing the Normalized Protein Catabolic Rate due to Use of Single-pool Urea Kinetic Modeling or to Omission of the Residual Kidney Urea Clearance.

    Science.gov (United States)

    Daugirdas, John T

    2017-07-01

    The protein catabolic rate normalized to body size (PCRn) often is computed in dialysis units to obtain information about protein ingestion. However, errors can manifest when inappropriate modeling methods are used. We used a variable volume 2-pool urea kinetic model to examine the percent errors in PCRn due to use of a 1-pool urea kinetic model or after omission of residual urea clearance (Kru). When a single-pool model was used, 2 sources of errors were identified. The first, dependent on the ratio of dialyzer urea clearance to urea distribution volume (K/V), resulted in a 7% inflation of the PCRn when K/V was in the range of 6 mL/min per L. A second, larger error appeared when Kt/V values were below 1.0 and was related to underestimation of urea distribution volume (due to overestimation of effective clearance) by the single-pool model. A previously reported prediction equation for PCRn was valid, but data suggest that it should be modified using 2-pool eKt/V and V coefficients instead of single-pool values. A third source of error, this one unrelated to use of a single-pool model, namely omission of Kru, was shown to result in an underestimation of PCRn, such that each ml/minute Kru per 35 L of V caused a 5.6% underestimate in PCRn. Marked overestimation of PCRn can result due to inappropriate use of a single-pool urea kinetic model, particularly when Kt/V <1.0 (as in short daily dialysis), or after omission of residual native kidney clearance. Copyright © 2017 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

  13. A single acidic residue can guide binding site selection but does not govern QacR cationic-drug affinity.

    Directory of Open Access Journals (Sweden)

    Kate M Peters

    Full Text Available Structures of the multidrug-binding repressor protein QacR with monovalent and bivalent cationic drugs revealed that the carboxylate side-chains of E90 and E120 were proximal to the positively charged nitrogens of the ligands ethidium, malachite green and rhodamine 6G, and therefore may contribute to drug neutralization and binding affinity. Here, we report structural, biochemical and in vivo effects of substituting these glutamate residues. Unexpectedly, substitutions had little impact on ligand affinity or in vivo induction capabilities. Structures of QacR(E90Q and QacR(E120Q with ethidium or malachite green took similar global conformations that differed significantly from all previously described QacR-drug complexes but still prohibited binding to cognate DNA. Strikingly, the QacR(E90Q-rhodamine 6G complex revealed two mutually exclusive rhodamine 6G binding sites. Despite multiple structural changes, all drug binding was essentially isoenergetic. Thus, these data strongly suggest that rather than contributing significantly to ligand binding affinity, the role of acidic residues lining the QacR multidrug-binding pocket is primarily to attract and guide cationic drugs to the "best available" positions within the pocket that elicit QacR induction.

  14. Exchanging a single amino acid residue generates or weakens a +2 cellooligosaccharide binding subsite in rice β-glucosidases.

    Science.gov (United States)

    Sansenya, Sompong; Maneesan, Janjira; Cairns, James R Ketudat

    2012-04-01

    Os3BGlu6, Os3BGlu7, and Os4BGlu12 are rice glycoside hydrolase family 1 β-glucosidases, the structures of which have been solved by X-ray crystallography. In complex structures, Os3BGlu7 residue Asn245 hydrogen bonds to the second sugar in the +1 subsite for laminaribiose and the third sugar in the +2 subsite for cellotetraose and cellopentaose. The corresponding Os3BGlu6 residue, Met251, appears to block the binding of cellooligosaccharides at the +2 subsite, whereas His252 in this position in Os4BGlu12 could hydrogen bond to oligosaccharides. Mutation of Os3BGlu6 Met251 to Asn resulted in a 15-fold increased k(cat)/K(m) value for hydrolysis of laminaribiose compared to wild type Os3BGlu6 and 9 to 24-fold increases for cellooligosaccharides with degrees of polymerization (DP) of 2-5. On the other hand, mutation of Os3BGlu7 Asn245 to Met decreased the k(cat)/K(m) of hydrolysis by 6.5-fold for laminaribiose and 17 to 30-fold for cellooligosaccharides with DP >2, while mutation of Os4BGlu12 His252 to Met decreased the corresponding k(cat)/K(m) values 2 to 6-fold. Copyright © 2012 Elsevier Ltd. All rights reserved.

  15. Notice of Violation of IEEE Publication PrinciplesJoint Redundant Residue Number Systems and Module Isolation for Mitigating Single Event Multiple Bit Upsets in Datapath

    Science.gov (United States)

    Li, Lei; Hu, Jianhao

    2010-12-01

    Notice of Violation of IEEE Publication Principles"Joint Redundant Residue Number Systems and Module Isolation for Mitigating Single Event Multiple Bit Upsets in Datapath"by Lei Li and Jianhao Hu,in the IEEE Transactions on Nuclear Science, vol.57, no.6, Dec. 2010, pp. 3779-3786After careful and considered review of the content and authorship of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE's Publication Principles.This paper contains substantial duplication of original text from the paper cited below. The original text was copied without attribution (including appropriate references to the original author(s) and/or paper title) and without permission.Due to the nature of this violation, reasonable effort should be made to remove all past references to this paper, and future references should be made to the following articles:"Multiple Error Detection and Correction Based on Redundant Residue Number Systems"by Vik Tor Goh and M.U. Siddiqi,in the IEEE Transactions on Communications, vol.56, no.3, March 2008, pp.325-330"A Coding Theory Approach to Error Control in Redundant Residue Number Systems. I: Theory and Single Error Correction"by H. Krishna, K-Y. Lin, and J-D. Sun, in the IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing, vol.39, no.1, Jan 1992, pp.8-17In this paper, we propose a joint scheme which combines redundant residue number systems (RRNS) with module isolation (MI) for mitigating single event multiple bit upsets (SEMBUs) in datapath. The proposed hardening scheme employs redundant residues to improve the fault tolerance for datapath and module spacings to guarantee that SEMBUs caused by charge sharing do not propagate among the operation channels of different moduli. The features of RRNS, such as independence, parallel and error correction, are exploited to establish the radiation hardening architecture for the datapath in radiation environments. In the proposed

  16. Illela border market: origin and contributions to trans-border ...

    African Journals Online (AJOL)

    Illela border market: origin and contributions to trans-border relations between Nigeria and Niger republic. ... cordial relations between her and her immediate neighbours and thus stem the scourge of smuggling and other trans-border crimes which have negatively affected the Nigerian economy and her international image.

  17. Comparison of sample digestion techniques for the determination of trace and residual catalyst metal content in single-wall carbon nanotubes by inductively coupled plasma mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Grinberg, Patricia, E-mail: patricia.grinberg@nrc.ca [Measurement Science and Standards, National Research Council Canada, Ottawa (Canada); Sturgeon, Ralph E. [Measurement Science and Standards, National Research Council Canada, Ottawa (Canada); Diehl, Liange de O.; Bizzi, Cezar A. [Measurement Science and Standards, National Research Council Canada, Ottawa (Canada); Chemistry Department, Universidade Federal de Santa Maria, Santa Maria (Brazil); Flores, Erico M.M. [Chemistry Department, Universidade Federal de Santa Maria, Santa Maria (Brazil)

    2015-03-01

    A single-wall carbon nanotube material produced by laser ablation of renewable biochar in the presence of Ni and Co catalyst was characterized for residual catalyst (Co and Ni) as well as trace metal impurity content (Fe, Mo, Cr, Pb and Hg) by isotope dilution ICP-MS following sample digestion. Several matrix destruction procedures were evaluated, including a multi-step microwave-assisted acid digestion, dry ashing at 450 °C and microwave-induced combustion with oxygen. Results were benchmarked against those derived from neutron activation analysis and also supported by solid sampling continuum source GF-AAS for several of the elements. Although laborious to execute, the multi-step microwave-assisted acid digestion proved to be most reliable for recovery of the majority of the analytes, although content of Cr remained biased low for each approach, likely due to its presence as refractory carbide. - Highlights: • Determination of trace and residual catalyst metal content in Single-Wall Carbon Nanotubes by Inductively Coupled Plasma Mass Spectrometry. • Comparative study of digestion methodology combined with high precision isotope dilution ICP-MS for quantitation of elements of toxicologic relevance. • Results were benchmarked against those derived from neutron activation analysis and also supported by solid sampling continuum source GF-AAS for several of the elements.

  18. Border Crossing/Entry Data

    Data.gov (United States)

    Department of Transportation — The dataset is known as “Border Crossing/Entry Data.” The Bureau of Transportation Statistics (BTS) Border Crossing/Entry Data provides summary statistics to the...

  19. Canada and Mexico Border Crossings

    Data.gov (United States)

    Department of Homeland Security — Border Crossing Ports are points of entry for land modes along the U.S. - Canadian and U.S.- Mexcian borders. The ports of entry are located in 15 states along the...

  20. Single-particle characterization of ice-nucleating particles and ice particles residuals sampled by three different techniques

    Science.gov (United States)

    Kandler, Konrad; Worringen, Annette; Benker, Nathalie; Dirsch, Thomas; Mertes, Stephan; Schenk, Ludwig; Kästner, Udo; Frank, Fabian; Nillius, Björn; Bundke, Ulrich; Rose, Diana; Curtius, Joachim; Kupiszewski, Piotr; Weingartner, Ernest; Vochezer, Paul; Schneider, Johannes; Schmidt, Susan; Weinbruch, Stephan; Ebert, Martin

    2015-04-01

    During January/February 2013, at the High Alpine Research Station Jungfraujoch a measurement campaign was carried out, which was centered on atmospheric ice-nucleating particles (INP) and ice particle residuals (IPR). Three different techniques for separation of INP and IPR from the non-ice-active particles are compared. The Ice Selective Inlet (ISI) and the Ice Counterflow Virtual Impactor (Ice-CVI) sample ice particles from mixed phase clouds and allow for the analysis of the residuals. The combination of the Fast Ice Nucleus Chamber (FINCH) and the Ice Nuclei Pumped Counterflow Virtual Impactor (IN-PCVI) provides ice-activating conditions to aerosol particles and extracts the activated INP for analysis. Collected particles were analyzed by scanning electron microscopy and energy-dispersive X-ray microanalysis to determine size, chemical composition and mixing state. All INP/IPR-separating techniques had considerable abundances (median 20 - 70 %) of instrumental contamination artifacts (ISI: Si-O spheres, probably calibration aerosol; Ice-CVI: Al-O particles; FINCH+IN-PCVI: steel particles). Also, potential sampling artifacts (e.g., pure soluble material) occurred with a median abundance of separated by all three techniques. Soot was a minor contributor. Lead was detected in less than 10 % of the particles, of which the majority were internal mixtures with other particle types. Sea-salt and sulfates were identified by all three methods as INP/IPR. Most samples showed a maximum of the INP/IPR size distribution at 400 nm geometric diameter. In a few cases, a second super-micron maximum was identified. Soot/carbonaceous material and metal oxides were present mainly in the submicron range. ISI and FINCH yielded silicates and Ca-rich particles mainly with diameters above 1 µm, while the Ice-CVI also separated many submicron IPR. As strictly parallel sampling could not be performed, a part of the discrepancies between the different techniques may result from

  1. Charged residues in the H-NS linker drive DNA binding and gene silencing in single cells.

    Science.gov (United States)

    Gao, Yunfeng; Foo, Yong Hwee; Winardhi, Ricksen S; Tang, Qingnan; Yan, Jie; Kenney, Linda J

    2017-11-21

    Nucleoid-associated proteins (NAPs) facilitate chromosome organization in bacteria, but the precise mechanism remains elusive. H-NS is a NAP that also plays a major role in silencing pathogen genes. We used genetics, single-particle tracking in live cells, superresolution microscopy, atomic force microscopy, and molecular dynamics simulations to examine H-NS/DNA interactions in single cells. We discovered a role for the unstructured linker region connecting the N-terminal oligomerization and C-terminal DNA binding domains. In the present work we demonstrate that linker amino acids promote engagement with DNA. In the absence of linker contacts, H-NS binding is significantly reduced, although no change in chromosome compaction is observed. H-NS is not localized to two distinct foci; rather, it is scattered all around the nucleoid. The linker makes DNA contacts that are required for gene silencing, while chromosome compaction does not appear to be an important H-NS function.

  2. Chimeras Reveal a Single Lipid-Interface Residue that Controls MscL Channel Kinetics as well as Mechanosensitivity

    Directory of Open Access Journals (Sweden)

    Li-Min Yang

    2013-02-01

    Full Text Available MscL, the highly conserved bacterial mechanosensitive channel of large conductance, serves as an osmotic “emergency release valve,” is among the best-studied mechanosensors, and is a paradigm of how a channel senses and responds to membrane tension. Although all homologs tested thus far encode channel activity, many show functional differences. We tested Escherichia coli and Staphylococcus aureus chimeras and found that the periplasmic region of the protein, particularly E. coli I49 and the equivalent S. aureus F47 at the periplasmic lipid-aqueous interface of the first transmembrane domain, drastically influences both the open dwell time and the threshold of channel opening. One mutant shows a severe hysteresis, confirming the importance of this residue in determining the energy barriers for channel gating. We propose that this site acts similarly to a spring for a clasp knife, adjusting the resistance for obtaining and stabilizing an open or closed channel structure.

  3. Business, brokers and borders

    DEFF Research Database (Denmark)

    Walther, Olivier

    2015-01-01

    The objective of this paper is to show how a formal approach to networks can make a significant contribution to the study of cross-border trade in West Africa. Building on the formal tools and theories developed by Social Network Analysis, we examine the network organization of 136 large traders...... in two border regions between Niger, Nigeria, and Benin. In a business environment where transaction costs are extremely high, we find that decentralized networks are well adapted to the various uncertainties induced by long-distance trade. We also find that long-distance trade relies both on the trust...... and cooperation shared among local traders, and on the distant ties developed with foreign partners from a different origin, religion or culture. Studying the spatial structure of trade networks, we find that in those markets where trade is recent and where most of the traders are not native of the region...

  4. Border cell release

    DEFF Research Database (Denmark)

    Mravec, Jozef

    2017-01-01

    Plant border cells are specialised cells derived from the root cap with roles in the biomechanics of root growth and in forming a barrier against pathogens. The mechanism of highly localised cell separation which is essential for their release to the environment is little understood. Here I present...... in situ analysis of Brachypodium distachyon, a model organism for grasses which possess type II primary cell walls poor in pectin content. Results suggest similarity in spatial dynamics of pectic homogalacturonan during dicot and monocot border cell release. Integration of observations from different...... species leads to the hypothesis that this process most likely does not involve degradation of cell wall material but rather employs unique cell wall structural and compositional means enabling both the rigidity of the root cap as well as detachability of given cells on its surface....

  5. Stretching the Border

    DEFF Research Database (Denmark)

    Horstmann, Alexander

    2014-01-01

    In this paper, I hope to add a complementary perspective to James Scott’s recent work on avoidance strategies of subaltern mountain people by focusing on what I call the refugee public. The educated Karen elite uses the space of exile in the Thai borderland to reconstitute resources and to re-ent......-based organizations succeed to stretch the border by establishing a firm presence that is supported by the international humanitarian economy in the refugee camps in Northwestern Thailand....

  6. Single-particle characterization of ice-nucleating particles and ice particle residuals sampled by three different techniques

    Science.gov (United States)

    Worringen, A.; Kandler, K.; Benker, N.; Dirsch, T.; Mertes, S.; Schenk, L.; Kästner, U.; Frank, F.; Nillius, B.; Bundke, U.; Rose, D.; Curtius, J.; Kupiszewski, P.; Weingartner, E.; Vochezer, P.; Schneider, J.; Schmidt, S.; Weinbruch, S.; Ebert, M.

    2015-04-01

    In the present work, three different techniques to separate ice-nucleating particles (INPs) as well as ice particle residuals (IPRs) from non-ice-active particles are compared. The Ice Selective Inlet (ISI) and the Ice Counterflow Virtual Impactor (Ice-CVI) sample ice particles from mixed-phase clouds and allow after evaporation in the instrument for the analysis of the residuals. The Fast Ice Nucleus Chamber (FINCH) coupled with the Ice Nuclei Pumped Counterflow Virtual Impactor (IN-PCVI) provides ice-activating conditions to aerosol particles and extracts the activated particles for analysis. The instruments were run during a joint field campaign which took place in January and February 2013 at the High Alpine Research Station Jungfraujoch (Switzerland). INPs and IPRs were analyzed offline by scanning electron microscopy and energy-dispersive X-ray microanalysis to determine their size, chemical composition and mixing state. Online analysis of the size and chemical composition of INP activated in FINCH was performed by laser ablation mass spectrometry. With all three INP/IPR separation techniques high abundances (median 20-70%) of instrumental contamination artifacts were observed (ISI: Si-O spheres, probably calibration aerosol; Ice-CVI: Al-O particles; FINCH + IN-PCVI: steel particles). After removal of the instrumental contamination particles, silicates, Ca-rich particles, carbonaceous material and metal oxides were the major INP/IPR particle types obtained by all three techniques. In addition, considerable amounts (median abundance mostly a few percent) of soluble material (e.g., sea salt, sulfates) were observed. As these soluble particles are often not expected to act as INP/IPR, we consider them as potential measurement artifacts. Minor types of INP/IPR include soot and Pb-bearing particles. The Pb-bearing particles are mainly present as an internal mixture with other particle types. Most samples showed a maximum of the INP/IPR size distribution at 200

  7. Metrics for border management systems.

    Energy Technology Data Exchange (ETDEWEB)

    Duggan, Ruth Ann

    2009-07-01

    There are as many unique and disparate manifestations of border systems as there are borders to protect. Border Security is a highly complex system analysis problem with global, regional, national, sector, and border element dimensions for land, water, and air domains. The complexity increases with the multiple, and sometimes conflicting, missions for regulating the flow of people and goods across borders, while securing them for national security. These systems include frontier border surveillance, immigration management and customs functions that must operate in a variety of weather, terrain, operational conditions, cultural constraints, and geopolitical contexts. As part of a Laboratory Directed Research and Development Project 08-684 (Year 1), the team developed a reference framework to decompose this complex system into international/regional, national, and border elements levels covering customs, immigration, and border policing functions. This generalized architecture is relevant to both domestic and international borders. As part of year two of this project (09-1204), the team determined relevant relative measures to better understand border management performance. This paper describes those relative metrics and how they can be used to improve border management systems.

  8. BORDERS AS AN INTERDISCPLINARY PROBLEM

    Directory of Open Access Journals (Sweden)

    Duško Vrban

    2018-04-01

    Full Text Available This article deals with the concepts of space and territoriality in law and politics seen through reflexion on borders, which are understood primarily as forms of identification and the basis for nation-building. While in the classical antiquity, borders were seen as exclusionary defensive structures, in modern international law in the 18th and 19th centuries, they became spaces for the delimitation of states sovereign territories. The author attempts to enligthen the symbolic significance of borders in modern European history, which have been connected with imperial designs, nationalist discourses and political imaginaries. Border rhetoric often emphasised territorial inclusions and exclusions relied to the concepts such as sovereignty, security and natural living space (“natural borders”. The concept of borders is also related to the understanding of the division of Earth’s surface into areas defined as regions. Regions may construct and transcend natural and political borders. Although, borders have been through world history sites of conflict, they also build ways of interconnections between locals and neighbours. The struggle over cultural and political domination and attempts to integrate and assimilate border populations were mostly reflected into deliberate linguistic policies relating to the language of administration and the public sphere. After the Second world war, the perception of borders have changed and the new understanding of borders have prevailed, based upon the idea of cooperation and the recognition of local traditions and minority rights. The principle of uti possidetis iuris was applied in order to prevent redrawing of the borders of new states and to maintain the territorial stability of the regions. But the recent migration crisis and security concerns in Europe and America have re-actualised the perception of state borders as defensive structures. Moreover, introduction of new technologies, such as ICT and the

  9. Overcoming the problem of residual microbial contamination in dental suction units left by conventional disinfection using novel single component suction handpieces in combination with automated flood disinfection.

    Science.gov (United States)

    Boyle, M A; O'Donnell, M J; Russell, R J; Galvin, N; Swan, J; Coleman, D C

    2015-10-01

    Decontaminating dental chair unit (DCU) suction systems in a convenient, safe and effective manner is problematic. This study aimed to identify and quantify the extent of the problems using 25 DCUs, methodically eliminate these problems and develop an efficient approach for reliable, effective, automated disinfection. DCU suction system residual contamination by environmental and human-derived bacteria was evaluated by microbiological culture following standard aspiration disinfection with a quaternary ammonium disinfectant or alternatively, a novel flooding approach to disinfection. Disinfection of multicomponent suction handpieces, assembled and disassembled, was also studied. A prototype manual and a novel automated Suction Tube Cleaning System (STCS) were developed and tested, as were novel single component suction handpieces. Standard aspiration disinfection consistently failed to decontaminate DCU suction systems effectively. Semi-confluent bacterial growth (101-500 colony forming units (CFU) per culture plate) was recovered from up to 60% of suction filter housings and from up to 19% of high and 37% of low volume suction hoses. Manual and automated flood disinfection of DCU suction systems reduced this dramatically (ranges for filter cage and high and low volume hoses of 0-22, 0-16 and 0-14CFU/plate, respectively) (P<0.0001). Multicomponent suction handpieces could not be adequately disinfected without prior removal and disassembly. Novel single component handpieces, allowed their effective disinfection in situ using the STCS, which virtually eliminated contamination from the entire suction system. Flood disinfection of DCU suction systems and single component handpieces radically improves disinfection efficacy and considerably reduces potential cross-infection and cross-contamination risks. DCU suction systems become heavily contaminated during use. Conventional disinfection does not adequately control this. Furthermore, multicomponent suction handpieces

  10. Atmospheric Science Without Borders

    Science.gov (United States)

    Panday, Arnico; Praveen, Ps; Adhikary, Bhupesh; Bhave, Prakash; Surapipith, Vanisa; Pradhan, Bidya; Karki, Anita; Ghimire, Shreta; Thapa, Alpha; Shrestha, Sujan

    2016-04-01

    The Indo-Gangetic Plains (IGP) in northern South Asia are among the most polluted and most densely populated places in the world, and they are upwind of vulnerable ecosystems in the Himalaya mountains. They are also fragmented across 5 countries between which movement of people, data, instruments and scientific understanding have been very limited. ICIMOD's Atmosphere Initiative has for the past three years been working on filling data gaps in the region, while facilitating collaborations across borders. It has established several atmospheric observatories at low and mid elevations in Bhutan and Nepal that provide new data on the inflow of pollutants from the IGP towards the mountains, as well as quantify the effects of local emissions on air quality in mountain cities. EGU will be the first international conference where these data will be presented. ICIMOD is in the process of setting up data servers through which data from the region will be shared with scientists and the general public across borders. Meanwhile, to promote cross-border collaboration among scientists in the region, while addressing an atmospheric phenomenon that affects the lives of the several hundred million people, ICIMOD' Atmosphere Initiative has been coordinating an interdisciplinary multi-year study of persistent winter fog over the Indo-Gangetic Plains, with participation by researchers from Pakistan, India, China, Nepal, Bhutan and Bangladesh. Using a combination of in-situ measurements and sample collection, remote sensing, modeling and community based research, the researchers are studying how changing moisture availability and air pollution have led to increases in fog frequency and duration, as well as the fog's impacts on local communities and energy demand that may affect air pollution emissions. Preliminary results of the Winter 2015-2016 field campaign will be shown.

  11. UNESCO Without Borders

    DEFF Research Database (Denmark)

    The United Nations Educational, Scientific, and Cultural Organization (UNESCO) was established in 1945 with twin aims: to rebuild various institutions of the world destroyed by war, and to promote international understanding and peaceful cooperation among nations. Based on empirical and historical...... research and with a particular focus on history teaching, international understanding and peace, UNESCO Without Borders offers a new research trajectory for understanding the roles played by UNESCO and other international organizations, as well as the effects of globalization on education. With fifteen...

  12. An optimized single chain TCR scaffold relying on the assembly with the native CD3-complex prevents residual mispairing with endogenous TCRs in human T-cells

    Science.gov (United States)

    Knies, Diana; Klobuch, Sebastian; Xue, Shao-An; Birtel, Matthias; Echchannaoui, Hakim; Yildiz, Oezlem; Omokoko, Tana; Guillaume, Philippe; Romero, Pedro; Stauss, Hans; Sahin, Ugur; Herr, Wolfgang; Theobald, Matthias; Thomas, Simone; Voss, Ralf-Holger

    2016-01-01

    Immunotherapy of cancer envisions the adoptive transfer of T-cells genetically engineered with tumor-specific heterodimeric α/β T-cell receptors (TCRα/β). However, potential mispairing of introduced TCRα/β-chains with endogenous β/α-ones may evoke unpredictable autoimmune reactivities. A novel single chain (sc)TCR format relies on the fusion of the Vα-Linker-Vβ-fragment to the TCR Cβ-domain and coexpression of the TCR Cα-domain capable of recruiting the natural CD3-complex for full and hence, native T-cell signaling. Here, we tested whether such a gp100(280-288)- or p53(264-272) tumor antigen-specific scTCR is still prone to mispairing with TCRα. In a human Jurkat-76 T-cell line lacking endogenous TCRs, surface expression and function of a scTCR could be reconstituted by any cointroduced TCRα-chain indicating mispairing to take place on a molecular basis. In contrast, transduction into human TCRα/β-positive T-cells revealed that mispairing is largely reduced. Competition experiments in Jurkat-76 confirmed the preference of dcTCR to selfpair and to spare scTCR. This also allowed for the generation of dc/scTCR-modified cytomegalovirus/tumor antigen-bispecific T-cells to augment T-cell activation in CMV-infected tumor patients. Residual mispairing was prevented by strenghtening the Vα-Li-Vβ-fragment through the design of a novel disulfide bond between a Vα- and a linker-resident residue close to Vβ. Multimer-stainings, and cytotoxicity-, IFNγ-secretion-, and CFSE-proliferation-assays, the latter towards dendritic cells endogenously processing RNA-electroporated gp100 antigen proved the absence of hybrid scTCR/TCRα-formation without impairing avidity of scTCR/Cα in T-cells. Moreover, a fragile cytomegalovirus pp65(495-503)-specific scTCR modified this way acquired enhanced cytotoxicity. Thus, optimized scTCR/Cα inhibits residual TCR mispairing to accomplish safe adoptive immunotherapy for bulk endogenous TCRα/β-positive T-cells. PMID:27028870

  13. Eficiência dos testes COPAN (Microplate e Single na detecção de resíduos de antimicrobianos no leite Efficacy of COPAN (Microplate and Single kits in detection of antimicrobials residues in milk

    Directory of Open Access Journals (Sweden)

    C.G.M.S.C. Tenório

    2009-04-01

    Full Text Available Avaliou-se a eficiência dos testes microbiológicos COPAN (Microplate e Single para detecção de resíduos de 13 antimicrobianos inoculados em leite isento de resíduos. Foram utilizadas quatro concentrações, sendo a primeira equivalente à metade do limite de detecção declarado pelo fabricante (C1; a segunda equivalente ao limite máximo de resíduos (LMR estabelecido pela legislação brasileira (C2; a terceira equivalente ao limite de detecção declarado pelo fabricante (C3; e a quarta equivalente ao dobro do limite de detecção declarado pelo fabricante (C4. Os testes apresentaram 100% de sensibilidade na detecção de amoxicilina, ampicilina, cloxacilina, penicilina, tilosina, sulfadiazina, sulfametoxazol, e 96,7% na detecção de oxacilina para as concentrações informadas pelo fabricante como limite de detecção. Em relação às concentrações estabelecidas pela legislação brasileira, verificou-se que os testes foram capazes de detectá-las para a maioria dos antimicrobianos avaliados. Os testes não se mostraram eficientes na detecção das concentrações estabelecidas pela legislação para eritromicina, oxitetraciclina, tetraciclina, trimetoprim e gentamicina (Microplate.The efficacy of the microbiological kits COPAN (Microplate and Single for detection of antimicrobials residues was tested. Thirteen drugs were inoculated into milk without residues at four concentration levels: C1 - half of the detection threshold declared by the manufacturer, C2 - the maximum residues threshold established by the Brazilian legislation, C3 - the detection threshold declared by the manufacturer, and C4 - two fold the detection threshold declared by the manufacturer. The tests showed 100% efficient in detection of amoxicillin, cloxacillin, penicillin, tilosin, sulfadiazine, and sulfa methoxazol; and 96.7% for oxacillin considering the concentration stated by the manufacturer as threshold level. Regarding the concentrations established by

  14. Does knowledge have borders?

    DEFF Research Database (Denmark)

    Tange, Hanne

    International education is often promoted through discourses of openness, cross-cultural relationship-building and global understanding. But how inclusive is the kind of knowledge offered in the so-called “global” learning environments? The paper explores possible limits to knowledge production a...... and represented within their course and academic discipline. We will present in the paper the preliminary findings of our research, pointing to some of the visible and invisible borders that one finds within the field of global education....... system embedded in a specific national and institutional environment, and from this research follows that certain frames of reference, or contexts, are taken for granted by local staff and students. With internationalization, however, comes a change in the make-up of the student cohort, including...

  15. Cross border relationships

    DEFF Research Database (Denmark)

    Singla, Rashmi; Sriram, Sujata

    2010-01-01

    in which they were born. These movements also imply human relationships across the borders in different contexts with various cultural, psychological consequences. Relationships of members of migrant groups with each other, and also with the host community have important implications on the health and well......-being of not just the migrant population, but also the host communities. These relationships represent the microcosm of societal and cultural integration and cohesion at the broader levels. Studies of how and how well migrants, especially youth handle migration indicate transformations in paradigms as both...... acculturative stress and developmental possibilities are realities experienced in the search of new worlds and new opportunities. The symposia will include such changes from Denmark, India, UK and the USA, covering theoretical, methodological issues including the ethical aspects. Themes involved in crossing...

  16. Border mythology: Turner and modernity

    Directory of Open Access Journals (Sweden)

    Jorge E. Brenna B.

    2011-07-01

    Full Text Available Modernity has been creating spaces, new boundaries and borders, as metaphysical, mythological and symbolic marks of physical and imaginary territories. Modern space and its borders are metaphors, boundaries that are created, walls that rise to identify with some and categorize others. In this short paper we want to approach the problem of the transformation of the idea of border (geographical, cultural, symbolic, etc., for a reflection on the transformations of that civilized obsession called border. The border has always been a reference in facing the identities, names, symbols, different imaginary: it is more confrontational line between two otherness. From the previous framework, we reflect on Turnerian mythology, as we believe that behind the creation of the imagination of the northern border is the mythical vision of the American frontier as ideological canon that explains and confirms the presence of the white race in a border re–made in the image and likeness of the “American Dream”. Frederick Turner’s reflection on the role of the frontier in American history is not only the study of the importance of progress towards the West but –even more so, is the analysis of meaning that had the American frontier as a historical process that ended in 1893, as Turner said, but rather extended into the twentieth century and continues to constantly shaping the process of territorialization of the border.

  17. Border trees of complex networks

    International Nuclear Information System (INIS)

    Villas Boas, Paulino R; Rodrigues, Francisco A; Travieso, Gonzalo; Fontoura Costa, Luciano da

    2008-01-01

    The comprehensive characterization of the structure of complex networks is essential to understand the dynamical processes which guide their evolution. The discovery of the scale-free distribution and the small-world properties of real networks were fundamental to stimulate more realistic models and to understand important dynamical processes related to network growth. However, the properties of the network borders (nodes with degree equal to 1), one of its most fragile parts, remained little investigated and understood. The border nodes may be involved in the evolution of structures such as geographical networks. Here we analyze the border trees of complex networks, which are defined as the subgraphs without cycles connected to the remainder of the network (containing cycles) and terminating into border nodes. In addition to describing an algorithm for identification of such tree subgraphs, we also consider how their topological properties can be quantified in terms of their depth and number of leaves. We investigate the properties of border trees for several theoretical models as well as real-world networks. Among the obtained results, we found that more than half of the nodes of some real-world networks belong to the border trees. A power-law with cut-off was observed for the distribution of the depth and number of leaves of the border trees. An analysis of the local role of the nodes in the border trees was also performed

  18. Conserved gene regulatory module specifies lateral neural borders across bilaterians.

    Science.gov (United States)

    Li, Yongbin; Zhao, Di; Horie, Takeo; Chen, Geng; Bao, Hongcun; Chen, Siyu; Liu, Weihong; Horie, Ryoko; Liang, Tao; Dong, Biyu; Feng, Qianqian; Tao, Qinghua; Liu, Xiao

    2017-08-01

    The lateral neural plate border (NPB), the neural part of the vertebrate neural border, is composed of central nervous system (CNS) progenitors and peripheral nervous system (PNS) progenitors. In invertebrates, PNS progenitors are also juxtaposed to the lateral boundary of the CNS. Whether there are conserved molecular mechanisms determining vertebrate and invertebrate lateral neural borders remains unclear. Using single-cell-resolution gene-expression profiling and genetic analysis, we present evidence that orthologs of the NPB specification module specify the invertebrate lateral neural border, which is composed of CNS and PNS progenitors. First, like in vertebrates, the conserved neuroectoderm lateral border specifier Msx/vab-15 specifies lateral neuroblasts in Caenorhabditis elegans Second, orthologs of the vertebrate NPB specification module ( Msx/vab-15 , Pax3/7/pax-3 , and Zic/ref-2 ) are significantly enriched in worm lateral neuroblasts. In addition, like in other bilaterians, the expression domain of Msx/vab-15 is more lateral than those of Pax3/7/pax-3 and Zic/ref- 2 in C. elegans Third, we show that Msx/vab-15 regulates the development of mechanosensory neurons derived from lateral neural progenitors in multiple invertebrate species, including C. elegans , Drosophila melanogaster , and Ciona intestinalis We also identify a novel lateral neural border specifier, ZNF703/tlp-1 , which functions synergistically with Msx/vab- 15 in both C. elegans and Xenopus laevis These data suggest a common origin of the molecular mechanism specifying lateral neural borders across bilaterians.

  19. Coumarins as turn on/off fluorescent probes for detection of residual acetone in cosmetics following headspace single-drop microextraction.

    Science.gov (United States)

    Cabaleiro, N; de la Calle, I; Bendicho, C; Lavilla, I

    2014-11-01

    In this work, a new method based on headspace-single drop microextraction for the determination of residual acetone in cosmetics by microfluorospectrometry is proposed. Acetone causes fluorescence changes in a 2.5 µL-ethanolic drop (40% v/v) containing 3.10(-4) mol L(-1) 7-hydroxy-4-methylcoumarin ('turn off') or 6.10(-6) mol L(-1) 7-diethylamino-4-methylcoumarin ('turn on'). Polarity and ability to form hydrogen bonds of short chain alcohols (polar protic solvents) were crucial in order to observe these changes in the presence of acetone (polar aprotic solvent). Parameters related with the HS-SDME procedure were studied, namely headspace volume, composition, volume and temperature of drop, microextraction time, stirring rate, mass and temperature of sample, as well as the effect of potential interferents (alcohols and fragrances). The high volatility of acetone allows its extraction from an untreated cosmetic sample within 3 min. A detection limit of 0.26 µg g(-1) and repeatability, expressed as relative standard deviation, around 5% were reached. Accuracy of the proposed methodology was evaluated by means of recovery studies. The method was successfully used to analyze different cosmetics. Simplicity and high sample throughput can be highlighted. Copyright © 2014 Elsevier B.V. All rights reserved.

  20. Cross border transport of vitrified residues from France to Germany

    International Nuclear Information System (INIS)

    Graf, W.; Jussofie, A.

    2016-01-01

    Until 1994 reprocessing was the only legal way to manage German spent fuel. Since in 1984 the national reprocessing concept was abandoned the reprocessing abroad was the only existing disposal route. With the amendment of the Atomic Energy Act in 2002 spent fuel management changed completely since from 1 June 2005 any delivery of spent fuel to reprocessing plants was prohibited and the direct disposal of spent fuel became mandatory. Until 2005 the total amount of spent fuel to be reprocessed abroad added up to 6080 t HM, 5309 t HM thereof in France. According to the commercial contracts signed between the German utilities and COGEMA, now AREVA NC, in France and BNFL, now INS in UK, and to the intergovernmental agreements concluded between Germany and France or UK the waste generated from reprocessing has to be returned to Germany. The return of high active vitrified waste from La Hague to the interim storage facility at Gorleben was not only demanding from the view of safety ensured by the cask design but especially for security reasons since the Gorleben area served as a target for nuclear opponents from the first transport in 1996 to the latest one in 2010. The protection against sabotage of the railway lines and mass protests needed improved security measures. Special working forces and projects have been set up in France and Germany to cope with this situation. A complex transport organization was necessary to involve all parties in line with the German and French security requirements during transport. All transports have been completed successfully so far thus confirming the efficiency of the applied measures. (author)

  1. Structure of the human vitreoretinal border region

    DEFF Research Database (Denmark)

    Heegaard, Steffen

    1994-01-01

    Øjenpatologi, vitreoretinal border region, inner limiting membrane, retina, topographical variation, human......Øjenpatologi, vitreoretinal border region, inner limiting membrane, retina, topographical variation, human...

  2. three intelligence methodologies for border defence and border

    African Journals Online (AJOL)

    Administrator

    Of these there are three intelligence methodologies applicable to this article – trends ..... globalisation associated with open and artificial borders and ever increasing costs of weapon ..... the technological development of mass tourist transport.

  3. Securing the Borders: Creation of the Border Patrol Auxiliary

    Science.gov (United States)

    2007-05-05

    DATES COVERED 00-00-2007 to 00-00-2007 4. TITLE AND SUBTITLE Securing the Borders: Creation of the Border Patrol Auxillary 5a. CONTRACT NUMBER...Substantial work experience which demonstrates an ability to (1) take charge, make sound decisions , and maintain composure in stressful situations; (2...applicable laws, court decisions , and law enforcement procedures; and 4. Develop and maintain contact with the network of informants. ¾ To qualify at

  4. Border Security: Barriers Along the U.S. International Border

    Science.gov (United States)

    2009-03-16

    1980). 120 Mexican Government Press Release, “Crecimiento con Calidad: El Presidente Vicente Fox encabezará la cena de gala de la XI Cumbre Anual...and Roads at Various Project Areas Located in California, Arizona, New Mexico , and Texas...Diego Border Primary Fence The USBP’s San Diego sector extends along the first 66 miles from the Pacific Ocean of the international border with Mexico

  5. Firemen without borders

    CERN Multimedia

    2005-01-01

    Fire knows no borders and neither should the tools for fighting it. It was with this aim in mind that delegates from 14 different countries came to CERN at the beginning of April to take part in the twentieth of a series of twice-yearly international conferences organised by the Federation of European Union Fire Officer Associations (FEU). This latest conference allowed participants to keep abreast of new developments with a view to improving the safety techniques used in their own countries. The first in the series was held in Tampere, Finland, in 1994. The FEU network's objective is to harmonise safety policies and modernise the fire-fighting programme. In particular, it aims to develop an international system for testing hotels' fire alarm systems and to improve language learning in all countries' fire-fighting services. "We want authorities throughout Europe to be aware of the importance of a good joint fire-prevention policy in order to avoid catastrophes such as the fire that destroyed Madrid's Winds...

  6. Internet-Based Cognitive Behavioral Therapy for Residual Symptoms in Bipolar Disorder Type II: A Single-Subject Design Pilot Study.

    Science.gov (United States)

    Holländare, Fredrik; Eriksson, Annsofi; Lövgren, Lisa; Humble, Mats B; Boersma, Katja

    2015-04-23

    Bipolar disorder is a chronic condition with recurring episodes that often lead to suffering, decreased functioning, and sick leave. Pharmacotherapy in the form of mood stabilizers is widely available, but does not eliminate the risk of a new depressive or (hypo)manic episode. One way to reduce the risk of future episodes is to combine pharmacological treatment with individual or group psychological interventions. However, access to such interventions is often limited due to a shortage of trained therapists. In unipolar depression there is now robust evidence of the effectiveness of Internet-based psychological interventions, usually comprising psychoeducation and cognitive behavioral therapy (CBT). Internet-based interventions for persons suffering from bipolar disorder could increase access to psychological treatment. The aim of this study was to investigate the feasibility of an Internet-based intervention, as well as its effect on residual depressive symptoms in persons diagnosed with bipolar disorder type II (BP-II). The most important outcomes were depressive symptoms, treatment adherence, and whether the patient perceived the intervention as helpful. A total of 7 patients diagnosed with bipolar disorder type II at a Swedish psychiatric outpatient clinic were offered the opportunity to participate. Of the 7 patients, 3 (43%) dropped out before treatment began, and 4 (57%) were treated by means of an online, Internet-based intervention based on CBT (iCBT). The intervention was primarily aimed at psychoeducation, treatment of residual depressive symptoms, emotion regulation, and improved sleep. All patients had ongoing pharmacological treatment at recruitment and established contact with a psychiatrist. The duration of BP-II among the treated patients was between 6 and 31 years. A single-subject design was used and the results of the 4 participating patients were presented individually. Initiating treatment was perceived as too demanding under current life

  7. Cross-border innovation cooperation

    DEFF Research Database (Denmark)

    Hjaltadóttir, Rannveig Edda; Makkonen, Teemu; Sørensen, Nils Karl

    2017-01-01

    Finding a suitable partner is paramount for the success of innovation cooperation. Thus, this paper sets out to analyse the determinants of cross-border innovation cooperation in Denmark by focusing on partner selection. The aim of the article is to investigate determinants of partner selection...... by taking the location of the partners into account. In particular, the discussion is tied to the notion of varying knowledge bases firms utilize in their innovation creation processes. Firm level data from the 2010 Community Innovation Survey in Denmark was utilized to analyse cross-border innovation...... of innovativeness increase the likelihood of cross-border innovation cooperation. Accordingly, geographical proximity to international borders is found to have a significant, positive effect on selecting partners within the European Union. The multivariate probit model shows that the decision of choosing a domestic...

  8. Crossing borders via mental bridges

    DEFF Research Database (Denmark)

    Keil, Dirk

    The project studies cross-border regional integration in Europe drawing on the example of the emerging Danish-German Femern Belt Region. It focuses on cross-border networking within public administration as part of regional integra- tion. My central question is how national-cultural differences...... influence coopera- tion, coordination and collaboration in administrative cross-border networks. In this connection the project asks after the perception of regional integration seen from the different national backgrounds. The research concentrates on the group of decision makers within the field of public...... administration, and in specific on the attempt to initiate and promote cross-border regional integration via the building of mental bridges between Danish and German parts of the Femern Belt Region. Here one of the first projects aiming primarily at building mental bridges in the Femern Belt Region...

  9. Structure-function paradigm in human myoglobin: how a single-residue substitution affects NO reactivity at low pO2.

    Science.gov (United States)

    Scorciapino, Mariano Andrea; Spiga, Enrico; Vezzoli, Alessandra; Mrakic-Sposta, Simona; Russo, Rosaria; Fink, Bruno; Casu, Mariano; Gussoni, Maristella; Ceccarelli, Matteo

    2013-05-22

    This work is focused on the two more expressed human myoglobin isoforms. In the literature, their different overexpression in high-altitude natives was proposed to be related to alternative/complementary functions in hypoxia. Interestingly, they differ only at residue-54, lysine or glutamate, which is external and far from the main binding site. In order to ascertain whether these two almost identical myoglobins might exert different functions and to contribute to a deeper understanding about myoglobin's oxygen-level dependent functioning, they have been compared with respect to dynamics, heme electronic structure, and NO reactivity at different O2 levels. Electron paramagnetic resonance (EPR) spectroscopy was employed to investigate the electronic structure of the nitrosyl-form, obtaining fundamental clues about a different bond interaction between the heme-iron and the proximal histidine and highlighting striking differences in NO reactivity, especially at a very low pO2. The experimental results well matched with the information provided by molecular dynamics simulations, which showed a significantly different dynamics for the two proteins only in the absence of O2. The single mutation differentiating the two myoglobins resulted in strongly affecting the plasticity of the CD-region (C-helix-loop-D-helix), whose fluctuations, being coupled to the solvent, were found to be correlated with the dynamics of the distal binding site. In the absence of O2, on the one hand a significantly different probability for the histidine-gate opening has been shown by MD simulations, and on the other a different yield of myoglobin-NO formation was experimentally observed through EPR.

  10. Online single particle analysis of ice particle residuals from mountain-top mixed-phase clouds using laboratory derived particle type assignment

    Science.gov (United States)

    Schmidt, Susan; Schneider, Johannes; Klimach, Thomas; Mertes, Stephan; Schenk, Ludwig Paul; Kupiszewski, Piotr; Curtius, Joachim; Borrmann, Stephan

    2017-01-01

    In situ single particle analysis of ice particle residuals (IPRs) and out-of-cloud aerosol particles was conducted by means of laser ablation mass spectrometry during the intensive INUIT-JFJ/CLACE campaign at the high alpine research station Jungfraujoch (3580 m a.s.l.) in January-February 2013. During the 4-week campaign more than 70 000 out-of-cloud aerosol particles and 595 IPRs were analyzed covering a particle size diameter range from 100 nm to 3 µm. The IPRs were sampled during 273 h while the station was covered by mixed-phase clouds at ambient temperatures between -27 and -6 °C. The identification of particle types is based on laboratory studies of different types of biological, mineral and anthropogenic aerosol particles. The outcome of these laboratory studies was characteristic marker peaks for each investigated particle type. These marker peaks were applied to the field data. In the sampled IPRs we identified a larger number fraction of primary aerosol particles, like soil dust (13 ± 5 %) and minerals (11 ± 5 %), in comparison to out-of-cloud aerosol particles (2.4 ± 0.4 and 0.4 ± 0.1 %, respectively). Additionally, anthropogenic aerosol particles, such as particles from industrial emissions and lead-containing particles, were found to be more abundant in the IPRs than in the out-of-cloud aerosol. In the out-of-cloud aerosol we identified a large fraction of aged particles (31 ± 5 %), including organic material and secondary inorganics, whereas this particle type was much less abundant (2.7 ± 1.3 %) in the IPRs. In a selected subset of the data where a direct comparison between out-of-cloud aerosol particles and IPRs in air masses with similar origin was possible, a pronounced enhancement of biological particles was found in the IPRs.

  11. Liouville gravity on bordered surfaces

    International Nuclear Information System (INIS)

    Jaskolski, Z.

    1991-11-01

    The functional quantization of the Liouville gravity on bordered surfaces in the conformal gauge is developed. It was shown that the geometrical interpretation of the Polyakov path integral as a sum over bordered surfaces uniquely determines the boundary conditions for the fields involved. The gravitational scaling dimensions of boundary and bulk operators and the critical exponents are derived. In particular, the boundary Hausdorff dimension is calculated. (author). 21 refs

  12. In-situ single particle composition analysis of free tropospheric ice nuclei and ice residues in mixed-phase clouds during INUIT-JFJ 2013

    Science.gov (United States)

    Schmidt, Susan; Schneider, Johannes; Thomas, Klimach; Stephan, Mertes; Ludwig, Schenk; Udo, Kästner; Frank, Stratmann; Joachim, Curtius; Piotr, Kupiszewski; Ernest, Weingartner; Emanuel, Hammer; Paul, Vochezer; Martin, Schnaiter; Stephan, Borrmann

    2014-05-01

    In the framework of the DFG (deutsche Forschungsgemeinschaft)-funded research unit INUIT (Ice Nuclei research UnIT) a field campaign at the High Alpine Research Station Jungfraujoch (JFJ, Swiss Alps, Sphinx Laboratory, 3580 m asl; 7°59'2''E, 46°32'53''N) took place in January/February 2013 (INUIT-JFJ 2013). The goal of the measurements was to investigate the chemical composition of ice particle residues (IPR) in ambient air as well as the background aerosol particles. Previous investigations conducted at the JFJ showed that particles consisting of mineral components dominate the ice particle residue number (Kamphus et al., 2008) but also particles consisting of black carbon were found to be enriched in IPR (Mertes et al., 2007; Cozic et al., 2008). Cziczo et al. find out that lead as well is a good ice nucleus and was measured in IPR at previous measurements at the JFJ. During INUIT-JFJ 2013, the IPR were sampled out of mixed-phase clouds by an Ice-CVI (Ice Counterflow Virtual Impactor, Mertes et al., 2007) and an ISI (Ice Selective Inlet, Kupiszewski et al., 2013) and analyzed by the single particle mass spectrometer ALABAMA (Aircraft-based Laser Ablation Aerosol Mass Spectrometer; Brands et al., 2011). Additionally, the ALABAMA was connected to a total aerosol-inlet to investigate the chemical composition of background aerosol particles. During 217 hours of background aerosol measurements we analyzed more than 27000 aerosol particles, which consisted mainly of pure organic components or organics mixed with ammonium, metals or mineral components. During six cloud events with approximately 63 h measurement time we detected 162 IPR sampled by the Ice-CVI. The main part of these IPR were also composed of organic material mixed with other chemical compounds. Additionally, we found particles which consisted of mineral components (approximately 23 %). Sampling mixed-phase cloud through the ISI we measured during four cloud events 34 ice residues in approximately 30 h

  13. Residual stresses

    International Nuclear Information System (INIS)

    Sahotra, I.M.

    2006-01-01

    The principal effect of unloading a material strained into the plastic range is to create a permanent set (plastic deformation), which if restricted somehow, gives rise to a system of self-balancing within the same member or reaction balanced by other members of the structure., known as residual stresses. These stresses stay there as locked-in stresses, in the body or a part of it in the absence of any external loading. Residual stresses are induced during hot-rolling and welding differential cooling, cold-forming and extruding: cold straightening and spot heating, fabrication and forced fitting of components constraining the structure to a particular geometry. The areas which cool more quickly develop residual compressive stresses, while the slower cooling areas develop residual tensile stresses, and a self-balancing or reaction balanced system of residual stresses is formed. The phenomenon of residual stresses is the most challenging in its application in surface modification techniques determining endurance mechanism against fracture and fatigue failures. This paper discusses the mechanism of residual stresses, that how the residual stresses are fanned and what their behavior is under the action of external forces. Such as in the case of a circular bar under limit torque, rectangular beam under limt moment, reclaiming of shafts welds and peening etc. (author)

  14. Residual stresses

    International Nuclear Information System (INIS)

    Macherauch, E.

    1978-01-01

    Residual stresses are stresses which exist in a material without the influence of external powers and moments. They come into existence when the volume of a material constantly changes its form as a consequence of mechanical, thermal, and/or chemical processes and is hindered by neighbouring volumes. Bodies with residual stress are in mechanical balance. These residual stresses can be manifested by means of all mechanical interventions disturbing this balance. Acoustical, optical, radiological, and magnetical methods involving material changes caused by residual stress can also serve for determining residual stress. Residual stresses have an ambivalent character. In technical practice, they are feared and liked at the same time. They cause trouble because they can be the cause for unexpected behaviour of construction elements. They are feared since they can cause failure, in the worst case with catastrophical consequences. They are appreciated, on the other hand, because, in many cases, they can contribute to improvements of the material behaviour under certain circumstances. But they are especially liked for their giving convenient and (this is most important) mostly uncontrollable explanations. For only in very few cases we have enough knowledge and possibilities for the objective evaluation of residual stresses. (orig.) [de

  15. Border detection in complex networks

    International Nuclear Information System (INIS)

    Travencolo, Bruno A N; Viana, Matheus Palhares; Costa, Luciano da Fontoura

    2009-01-01

    One important issue implied by the finite nature of real-world networks regards the identification of their more external (border) and internal nodes. The present work proposes a formal and objective definition of these properties, founded on the recently introduced concept of node diversity. It is shown that this feature does not exhibit any relevant correlation with several well-established complex networks measurements. A methodology for the identification of the borders of complex networks is described and illustrated with respect to theoretical (geographical and knitted networks) as well as real-world networks (urban and word association networks), yielding interesting results and insights in both cases.

  16. The 'border within': inhabiting the border in Trieste

    NARCIS (Netherlands)

    Bialasiewicz, L.; Minca, C.

    2010-01-01

    In this paper we look to the Italian border city of Trieste-at various points in its past, a cosmopolitan port, Austria's urbs europeissima, but also a battleground for competing understandings of territoriality, identity, and belonging and a paragon of the violent application of an ethnoterritorial

  17. Border Security: Barriers Along the U.S. International Border

    Science.gov (United States)

    2006-10-30

    Congressional Research Service ˜ The Library of Congress CRS Report for Congress Received through the CRS Web Order Code RL33659 Border Security...Presidencia,” May 12, 2005. Translation by CRS. Available at [http://www.presidencia.gob.mx/actividades/crecimiento/?contenido=18195& pagina =31]. Last

  18. Border Crossing/Entry Data - Boarder Crossing

    Data.gov (United States)

    Department of Transportation — Border Crossing/Entry Data provides summary statistics for incoming crossings at the U.S.-Canadian and the U.S.-Mexican border at the port level. Data are available...

  19. Structure of the animal vitreoretinal border region

    DEFF Research Database (Denmark)

    Heegaard, Steffen

    1994-01-01

    Øjenpatologi, vitreoretinal border region, inner limiting membrane of the retina, animals, ultrastructure, comparative anatomy......Øjenpatologi, vitreoretinal border region, inner limiting membrane of the retina, animals, ultrastructure, comparative anatomy...

  20. Developing a simulation for border safeguarding

    CSIR Research Space (South Africa)

    Van Rooyen, S

    2011-09-01

    Full Text Available Border safeguarding is the defence of territorial integrity and sovereignty, and this is a joint responsibility of the military and the police. Military doctrine for conventional warfare is not sufficient for Border Safeguarding operations due...

  1. Single molecule TPM analysis of the catalytic pentad mutants of Cre and Flp site-specific recombinases: contributions of the pentad residues to the pre-chemical steps of recombination

    Science.gov (United States)

    Fan, Hsiu-Fang; Cheng, Yong-Song; Ma, Chien-Hui; Jayaram, Makkuni

    2015-01-01

    Cre and Flp site-specific recombinase variants harboring point mutations at their conserved catalytic pentad positions were characterized using single molecule tethered particle motion (TPM) analysis. The findings reveal contributions of these amino acids to the pre-chemical steps of recombination. They suggest functional differences between positionally conserved residues in how they influence recombinase-target site association and formation of ‘non-productive’, ‘pre-synaptic’ and ‘synaptic’ complexes. The most striking difference between the two systems is noted for the single conserved lysine. The pentad residues in Cre enhance commitment to recombination by kinetically favoring the formation of pre-synaptic complexes. These residues in Flp serve a similar function by promoting Flp binding to target sites, reducing non-productive binding and/or enhancing the rate of assembly of synaptic complexes. Kinetic comparisons between Cre and Flp, and between their derivatives lacking the tyrosine nucleophile, are consistent with a stronger commitment to recombination in the Flp system. The effect of target site orientation (head-to-head or head-to-tail) on the TPM behavior of synapsed DNA molecules supports the selection of anti-parallel target site alignment prior to the chemical steps. The integrity of the synapse, whose establishment/stability is fostered by strand cleavage in the case of Flp but not Cre, appears to be compromised by the pentad mutations. PMID:25765648

  2. Multi-TSO cross border balancing mechanism

    Energy Technology Data Exchange (ETDEWEB)

    Llorens, Maria Luisa; Moreno, Laura; Fuente, Jose Ignacio de la; Junco, Paula; Arenillas, Jorge [Red Electrica de Espana (REE) S.A.U., Madrid (Spain). Operation Markets Dept.; Pereira, Pedro [REN - Servicos, S.A., Lisbon (Portugal). Gabinete Mercado e Liquidacoes; Chabanne, Colas [RTE Reseau de Transport d' Electricite, Paris (France). Markets Dept.; Apoyan, Lalake; Barbieri, Galileo [RTE Reseau de Transport d' Electricite, Paris (France). Cross-Border Market Design

    2012-07-01

    The balancing market integration has been highlighted as a necessary step to reach the European Union goal for the development of an effective, competitive single market for electricity across Europe. In this paper it is described the work done by RTE, REE and REN regarding the design of a non-discriminatory, efficient and reliable multi-TSO Cross Border Balancing Mechanism at regional level, extendible to other control areas. The implementation of this multi-TSO Cross Border Balancing Mechanism will aim at increasing the operational security, enhancing the Liquidity and Competition of balancing markets, facilitating the integration of energy produced by Renewable Energy Sources while optimizing the use of Interconnection capacities. With this mechanism, the three TSOs will be able to exchange to each other balancing energy through the available interconnection capacities after the last intraday market sessions. This mechanism will be based on a common IT platform where TSOs will share their available surplus of reserves and communicate their balancing needs. The available interconnection capacities will be taken into account in an automatic and centralized way. Two main options are investigated regarding the allocation method: on the one hand, the first come first served approach (FCFS), on the other hand, the ''social welfare'' optimization approach. (orig.)

  3. Introduction: Borders in Translation and Intercultural Communication

    Directory of Open Access Journals (Sweden)

    Jonathan Evans

    2017-09-01

    Full Text Available The introduction to this special issue discusses the notion of border and its position in current scholarship in translation studies and intercultural communication. It then analyses ways in which borders can be useful for thinking, focusing particularly on Walter Mignolo’s notion of “border thinking”. It reviews how borders are viewed in both translation studies and intercultural communication and offers some possible directions for future research before introducing the papers in this special issue.

  4. Solid residues

    International Nuclear Information System (INIS)

    Mulder, E.; Duin, P.J. van; Grootenboer, G.J.

    1995-01-01

    A summary is presented of the many investigations that have been done on solid residues of atmospheric fluid bed combustion (AFBC). These residues are bed ash, cyclone ash and bag filter ash. Physical and chemical properties are discussed and then the various uses of residues (in fillers, bricks, gravel, and for recovery of aluminium) are summarised. Toxicological properties of fly ash and stack ash are discussed as are risks of pneumoconiosis for workers handling fly ash, and contamination of water by ashes. On the basis of present information it is concluded that risks to public health from exposure to emissions of coal fly ash from AFBC appear small or negligible as are health risk to workers in the coal fly ash processing industry. 35 refs., 5 figs., 12 tabs

  5. Single residue mutation in active site of serine acetyltransferase isoform 3 from Entamoeba histolytica assists in partial regaining of feedback inhibition by cysteine.

    Directory of Open Access Journals (Sweden)

    Sudhir Kumar

    Full Text Available The cysteine biosynthetic pathway is essential for survival of the protist pathogen Entamoeba histolytica, and functions by producing cysteine for countering oxidative attack during infection in human hosts. Serine acetyltransferase (SAT and O-acetylserine sulfhydrylase (OASS are involved in cysteine biosynthesis and are present in three isoforms each. While EhSAT1 and EhSAT2 are feedback inhibited by end product cysteine, EhSAT3 is nearly insensitive to such inhibition. The active site residues of EhSAT1 and of EhSAT3 are identical except for position 208, which is a histidine residue in EhSAT1 and a serine residue in EhSAT3. A combination of comparative modeling, multiple molecular dynamics simulations and free energy calculation studies showed a difference in binding energies of native EhSAT3 and of a S208H-EhSAT3 mutant for cysteine. Mutants have also been generated in vitro, replacing serine with histidine at position 208 in EhSAT3 and replacing histidine 208 with serine in EhSAT1. These mutants showed decreased affinity for substrate serine, as indicated by K(m, compared to the native enzymes. Inhibition kinetics in the presence of physiological concentrations of serine show that IC50 of EhSAT1 increases by about 18 folds from 9.59 µM for native to 169.88 µM for H208S-EhSAT1 mutant. Similar measurements with EhSAT3 confirm it to be insensitive to cysteine inhibition while its mutant (S208H-EhSAT3 shows a gain of cysteine inhibition by 36% and the IC50 of 3.5 mM. Histidine 208 appears to be one of the important residues that distinguish the serine substrate from the cysteine inhibitor.

  6. Research of nitroxynil residues in bovine milk following a single administration in the dry period by ultra-performance liquid chromatography tandem mass spectrometry

    Directory of Open Access Journals (Sweden)

    Claudia Chirollo

    2013-10-01

    Full Text Available Nitroxynil (NIT is a halogenated phenol used to control fascioliasis in cattle and sheep. The Commission Regulation EU No 37/2010 has established maximum residue limits for NIT in bovine and ovine muscle (400 μg kg−1, fat (200 μg kg−1, liver (20 μg kg−1 and kidney (400 μg kg−1, and more recently in bovine and ovine milk (20 μg kg−1. Thirty-five pregnant dairy cows were treated in this study with nitroxynil (340 mg/mL solution for injection at the recommended dose of 10 mg/kg body weight at the start of the dry period, i.e. 53 to 74 days before the expected calving. Calving occurred between 43 days and 79 days after treatment. The concentrations of NIT in the milk were monitored for up to 120 days after calving. NIT residues were extracted using acetonitrile; magnesium sulfate and sodium chloride were added to induce liquid-liquid partitioning and purified by dispersive solid phase extraction for clean-up. NIT was detected by ultra high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS in negative ionization mode. The highest concentrations of this drug were found in two animals at the first milking, 48 and 53 day post treatment with levels of 362 and 657 μg kg–1, respectively. NIT residues were below the limit of detection of the method (0.24 μg/kg–1 between 67 and 106 day post-treatment. Following calving, residues rapidly depleted in animals and were non-detectable from 10 to 38 days post-calving. In particular, in all animals milk resulted compliant (<20 μg/kg−1 three days post partum.

  7. The impact of Border policy effect on cross-border ethnic areas

    Science.gov (United States)

    Bie, Q. L.; Zhou, S. Y.; Li, C. S.

    2013-11-01

    Boundary effect analysis is related to border policy making in the cross-border ethnic area. The border effect literatures show that geographic boundaries have obvious impacts on economic, social and cultural relations in both sides of a nation border. Particularly in cross-border ethnic areas, each ethnic group has strong internal spatial structure relevance, and the boundary effect is more obvious. However, most of China's border areas are cross-border ethnic areas, each of border issues is unique. Under this perspective, we analyze the border effects of various boundaries can provide basis for formulating border management policies. For small scale of cross-border ethnic minority areas, how to formulate the boundary management policy is a good question to explore. This paper is demonstrated by a study of the impact of border management policies in Dehong Dai and Jingpo Autonomous Prefecture in Yunnan Province at the border area to Burma. The comparative method is used to analysis the border management policies in past 50 decades for the border area of Yunnan Province .This research aims to define trends within border policy and its influences to national security. This paper also examines Wendy Brown's liberal theory of border management policy. We found that it is not suitable for Sino-Burma border area. The conclusion is that the changes or instability of international economic and political situation has more influence to this cross-border ethnic area, and only innovative policy will be effective in cross-border ethnic area. So the border management policies should reflect the change of international context.

  8. Briefing : the Eritrean-Ethiopian border dispute

    NARCIS (Netherlands)

    Abbink, G.J.

    1998-01-01

    On 6 May 1998, a violent conflict erupted in the Ethiopian-Eritrean border area. This article contends that this border crisis is neither unexpected nor the result of a real border dispute. Rather, it is due to three factors: the particular history and relationship of the two insurgent movements

  9. European Banks Straddling Borders: Risky or Rewarding?

    NARCIS (Netherlands)

    P. Duijm (Patty); D. Schoenmaker (Dirk)

    2017-01-01

    textabstractTheory suggests that cross-border banking is beneficial as long as there is a non-perfect correlation across country-specific risks. Using a unique hand-collected dataset with cross-border loans for the 61 largest European banks, we find that cross-border banking in general decreases

  10. Cross-Border Exposures and Financial Contagion

    NARCIS (Netherlands)

    Degryse, H.A.; Elahi, M.A.; Penas, M.F.

    2009-01-01

    Integrated financial markets provide opportunities for expansion and improved risk sharing, but also pose threats of contagion risk through cross-border exposures. This paper examines cross-border contagion risk over the period 1999-2006. To that purpose we use aggregate cross-border exposures of

  11. Recent trends in cross-border banking

    NARCIS (Netherlands)

    De Haas, Ralph; van Horen, Neeltje; Beck, Thorsten; Casu, Barbara

    2017-01-01

    This chapter identifies a number of recent trends in European cross-border banking. The authors first distinguish between two main modes of international banking: cross-border versus multinational banking. Cross-border banking occurs when a bank in country A lends directly to a borrower in country

  12. Old Borders and New Bordering Capabilities: Cities as Frontier Zones

    Directory of Open Access Journals (Sweden)

    Saskia Sassen

    2015-12-01

    Full Text Available The global city is a new frontier zone. Deregulation, privatization, and new fiscal and monetary policies create the formal instruments to construct their equivalent of the old military “fort”. The city is also a strategic frontier zone for those who lack power, and allows the making of informal politics. At the same time the border is a mix of regimes, marked by protections and opportunities for corporations and high-level professionals, and implies confinement, capture and detention for migrants. The essay discusses the transformation of the city in a frontier zone and analyses the separation between the capabilities entailed by territoriality and the geographic territory tout court. The analysis focuses on the effects of neoliberal policies that, far from making this a borderless world, have actually multiplied the bordered spaces that allow firms and markets to move across conventional borders. Cities are therefore one of the key sites where new neoliberal norms are made and where new identities emerge.

  13. Internal Border Controls in the European Union

    DEFF Research Database (Denmark)

    Jørgensen, Carsten Willemoes; Sørensen, Karsten Engsig

    2012-01-01

    Recent events, involving inter alia France and Denmark, have stimulated renewed interest in the introduction of different forms of border controls at the internal borders within the European Union. These border control measures are aimed at checking either persons or goods or both. Against...... the background of these events, this article analyses the existing rules regulating controls of persons and goods, and explores how these rules may or may not stand in the way of introducing border controls at the European Union’s internal borders. These events have resulted in a call for reforms of the current...

  14. Acetyl coenzyme A synthetase is acetylated on multiple lysine residues by a protein acetyltransferase with a single Gcn5-type N-acetyltransferase (GNAT) domain in Saccharopolyspora erythraea.

    Science.gov (United States)

    You, Di; Yao, Li-Li; Huang, Dan; Escalante-Semerena, Jorge C; Ye, Bang-Ce

    2014-09-01

    Reversible lysine acetylation (RLA) is used by cells of all domains of life to modulate protein function. To date, bacterial acetylation/deacetylation systems have been studied in a few bacteria (e.g., Salmonella enterica, Bacillus subtilis, Escherichia coli, Erwinia amylovora, Mycobacterium tuberculosis, and Geobacillus kaustophilus), but little is known about RLA in antibiotic-producing actinomycetes. Here, we identify the Gcn5-like protein acetyltransferase AcuA of Saccharopolyspora erythraea (SacAcuA, SACE_5148) as the enzyme responsible for the acetylation of the AMP-forming acetyl coenzyme A synthetase (SacAcsA, SACE_2375). Acetylated SacAcsA was deacetylated by a sirtuin-type NAD(+)-dependent consuming deacetylase (SacSrtN, SACE_3798). In vitro acetylation/deacetylation of SacAcsA enzyme was studied by Western blotting, and acetylation of lysine residues Lys(237), Lys(380), Lys(611), and Lys(628) was confirmed by mass spectrometry. In a strain devoid of SacAcuA, none of the above-mentioned Lys residues of SacAcsA was acetylated. To our knowledge, the ability of SacAcuA to acetylate multiple Lys residues is unique among AcuA-type acetyltransferases. Results from site-specific mutagenesis experiments showed that the activity of SacAcsA was controlled by lysine acetylation. Lastly, immunoprecipitation data showed that in vivo acetylation of SacAcsA was influenced by glucose and acetate availability. These results suggested that reversible acetylation may also be a conserved regulatory posttranslational modification strategy in antibiotic-producing actinomycetes. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

  15. Cross-border reprogenetic services.

    Science.gov (United States)

    Couture, V; Drouin, R; Tan, S-L; Moutquin, J-M; Bouffard, C

    2015-01-01

    The purpose of this review is to synthesize the current knowledge on the international movement of patients and biopsied embryo cells for pre-implantation genetic diagnosis and its different applications. Thus far, few attempts have been made to identify the specific nature of this phenomenon called 'cross-border reprogenetic services'. There is scattered evidence, both empirical and speculative, suggesting that these services raise major issues in terms of service provision, risks for patients and the children-to-come, the legal liabilities of physicians, as well as social justice. To compile this evidence, this review uses the narrative overview protocol combined with thematic analysis. Five major themes have emerged from the literature at the conjunction of cross-border treatments and reprogenetics: 'scope', 'scale', 'motivations', 'concerns', and 'governance'. Similar themes have already been observed in the case of other medical tourism activities, but this review highlights their singularity with reprogenetic services. It emphasizes the diagnostic and autologous feature of reprogenetics, the constant risk of misdiagnosis, the restriction on certain tests for medically controversial conditions, and the uncertain accessibility of genetic counseling in cross-border settings. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  16. Strengthening border control and management

    International Nuclear Information System (INIS)

    Chatzis, I.

    2008-01-01

    The world has experienced monumental changes in recent years. Globalization has brought many benefits. Business and commerce have increased and, as a result, brought us cheaper, more accessible goods from all regions of the world. We have access to relatively cheap and certainly much easier travel. We now live in a world of instant communications with mobile phones, laptops and 'BlackBerries'. However, there is a downside to globalization - transnationally organized crime and the reality of terrorism have grown. As more people cross borders, it is harder to detect criminals and terrorists. In the European Union, the internal borders of the now 27 member States have been dismantled. Effective international measures to counter organized crime and terrorist groups are of crucial importance. It is important to think globally and to act locally. The paper looks at some of the crime challenges and provides insight into the role and work of the United Nations Office on Drugs and Crime (UNODC) in drugs and crime control. It focuses on border control initiatives conducted by the UNODC. (author)

  17. Residues at a Single Site Differentiate Animal Cryptochromes from Cyclobutane Pyrimidine Dimer Photolyases by Affecting the Proteins' Preferences for Reduced FAD.

    Science.gov (United States)

    Xu, Lei; Wen, Bin; Wang, Yuan; Tian, Changqing; Wu, Mingcai; Zhu, Guoping

    2017-06-19

    Cryptochromes (CRYs) and photolyases belong to the cryptochrome/photolyase family (CPF). Reduced FAD is essential for photolyases to photorepair UV-induced cyclobutane pyrimidine dimers (CPDs) or 6-4 photoproducts in DNA. In Drosophila CRY (dCRY, a type I animal CRY), FAD is converted to the anionic radical but not to the reduced state upon illumination, which might induce a conformational change in the protein to relay the light signal downstream. To explore the foundation of these differences, multiple sequence alignment of 650 CPF protein sequences was performed. We identified a site facing FAD (Ala377 in Escherichia coli CPD photolyase and Val415 in dCRY), hereafter referred to as "site 377", that was distinctly conserved across these sequences: CPD photolyases often had Ala, Ser, or Asn at this site, whereas animal CRYs had Ile, Leu, or Val. The binding affinity for reduced FAD, but not the photorepair activity of E. coli photolyase, was dramatically impaired when replacing Ala377 with any of the three CRY residues. Conversely, in V415S and V415N mutants of dCRY, FAD was photoreduced to its fully reduced state after prolonged illumination, and light-dependent conformational changes of these mutants were severely inhibited. We speculate that the residues at site 377 play a key role in the different preferences of CPF proteins for reduced FAD, which differentiate animal CRYs from CPD photolyases. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. Cross-border shipment route selection utilizing analytic hierarchy process (AHP method

    Directory of Open Access Journals (Sweden)

    Veeris Ammarapala

    2018-02-01

    Full Text Available Becoming a member of ASEAN Economic Community (AEC, Thailand expects a growth of cross-border trade with neighboring countries, especially the agricultural products shipment. To facilitate this, a number of strategies are set, such as the utilization of single check point, the Asian Highway (AH route development, and the truck lane initiation. However, majority of agricultural products traded through the borders are transported using the rural roads, from growing area to the factory, before continuing to the borders using different highways. It is, therefore, necessary for the Department of Rural Roads (DRR to plan for rural road improvement to accommodate the growth of the cross-border trades in the near future. This research, thus, aims to select potential rural roads to support cross-border shipment utilizing the analytic hierarchy process (AHP method. Seven key factors affecting rural roads selection, with references from transport and other related literatures, are extracted. They include:1 cross-border trade value, 2 distance from border to rural road, 3 agriculture and processed agriculture goods transported across the border, 4 compatibility with national strategies, 5 area characteristics around the rural road, 6 truck volume, and 7 number of rural roads in the radius of 50 kilometers from the border. Interviews are conducted with the experts based on seven key factors to collect data for the AHP analysis. The results identify the weight of each factor with an acceptable consistency ratio. It shows that the cross-border trade value is the most important factor as it achieves the highest weight. The distance from border to rural road and the compatibility with national strategies are also found crucial when making rural road selection decision. The Department of Rural Roads could use the results to select suitable roads, and plan for road improvement to support the crossborder shipment when the AEC is fully implemented.

  19. Residual basins

    International Nuclear Information System (INIS)

    D'Elboux, C.V.; Paiva, I.B.

    1980-01-01

    Exploration for uranium carried out over a major portion of the Rio Grande do Sul Shield has revealed a number of small residual basins developed along glacially eroded channels of pre-Permian age. Mineralization of uranium occurs in two distinct sedimentary units. The lower unit consists of rhythmites overlain by a sequence of black shales, siltstones and coal seams, while the upper one is dominated by sandstones of probable fluvial origin. (Author) [pt

  20. B-ALL minimal residual disease flow cytometry: an application of a novel method for optimization of a single-tube model.

    Science.gov (United States)

    Shaver, Aaron C; Greig, Bruce W; Mosse, Claudio A; Seegmiller, Adam C

    2015-05-01

    Optimizing a clinical flow cytometry panel can be a subjective process dependent on experience. We develop a quantitative method to make this process more rigorous and apply it to B lymphoblastic leukemia/lymphoma (B-ALL) minimal residual disease (MRD) testing. We retrospectively analyzed our existing three-tube, seven-color B-ALL MRD panel and used our novel method to develop an optimized one-tube, eight-color panel, which was tested prospectively. The optimized one-tube, eight-color panel resulted in greater efficiency of time and resources with no loss in diagnostic power. Constructing a flow cytometry panel using a rigorous, objective, quantitative method permits optimization and avoids problems of interdependence and redundancy in a large, multiantigen panel. Copyright© by the American Society for Clinical Pathology.

  1. Frontier Government: The Folding of the Canada-US Border

    Directory of Open Access Journals (Sweden)

    Daniel O'Connor

    2009-10-01

    Full Text Available In this paper the border is evaluated as a fold of power relations in which sovereign capacity and competence is marshalled alongside strategies of control, surveillance, and risk management to constitute, what we call, a zone of frontier government. We advance the argument that the border is a site for both negative and positive power, for insertion and subtraction, and that the assemblage of surveillance and compliance regimes are "run" not so much in the furtherance of a precautionary or pre-emptive end-state, but as intermediate values that are sufficiently malleable by an invigorated sovereign, expressed in the residue of discretion in and between the many border agencies.  Our analysis is based on extensive policy and program documents, as well as twenty-five interviews with officials in various agencies engaged in the US-Canada and, particularly, the Windsor-Detroit corridor. Normal 0 false false false EN-CA X-NONE X-NONE

  2. Introduction : Borders, Informality, International Trade and Customs

    OpenAIRE

    Cantens, Thomas; Ireland, Robert; Raballand, Gael

    2015-01-01

    Trading goods is an original human activity that precedes borders (Renfrew, 1969). With the rise of nation-states with demarcated political boundaries, trade that crosses borders became regulated by government institutions such as Customs, with tariffs, quotas, or outright prohibitions. While borders are perhaps not quite “the dead, the fixed, the undialectical, the immobile” (Foucault, 1970, p. 70), they are a formal structure that places less flexibility on trade activities. Focusing on inf...

  3. Network communities within and across borders

    OpenAIRE

    Cerina, Federica; Chessa, Alessandro; Pammolli, Fabio; Riccaboni, Massimo

    2014-01-01

    We investigate the impact of borders on the topology of spatially embedded networks. Indeed territorial subdivisions and geographical borders significantly hamper the geographical span of networks thus playing a key role in the formation of network communities. This is especially important in scientific and technological policy-making, highlighting the interplay between pressure for the internationalization to lead towards a global innovation system and the administrative borders imposed by t...

  4. Aymara paradiplomacy: Empowerment in the border

    Directory of Open Access Journals (Sweden)

    Gilberto Aranda Bustamante

    2017-01-01

    Full Text Available This article analyzes the border paradiplomacy used by more than 50 municipalities from Bolivia, Chile and Peru, named “Aymaras without Borders Strategic Alliance”. In spite of the differentiated historical construction of national identities, according to a literature review, it could be argued that there is an unprecedented border relation between these three countries. Furthermore, it is possible to conclude that this non-violent strategy has been successful in the last 15 years.

  5. Competitive implications of cross-border banking

    OpenAIRE

    Claessens, Stijn

    2006-01-01

    This paper reviews the recent literature on cross-border banking, with a focus on policy implications. Cross-border banking has increased sharply in recent decades, particularly in the form of entry, and has affected the development of financial systems, access to financial services, and stability. Reviewing the empirical literature, the author finds much, although not uniform, evidence that cross-border banking supports the development of an efficient and stable financial system that offers ...

  6. A model for international border management systems.

    Energy Technology Data Exchange (ETDEWEB)

    Duggan, Ruth Ann

    2008-09-01

    To effectively manage the security or control of its borders, a country must understand its border management activities as a system. Using its systems engineering and security foundations as a Department of Energy National Security Laboratory, Sandia National Laboratories has developed such an approach to modeling and analyzing border management systems. This paper describes the basic model and its elements developed under Laboratory Directed Research and Development project 08-684.

  7. Phenotypic covariance at species' borders.

    Science.gov (United States)

    Caley, M Julian; Cripps, Edward; Game, Edward T

    2013-05-28

    Understanding the evolution of species limits is important in ecology, evolution, and conservation biology. Despite its likely importance in the evolution of these limits, little is known about phenotypic covariance in geographically marginal populations, and the degree to which it constrains, or facilitates, responses to selection. We investigated phenotypic covariance in morphological traits at species' borders by comparing phenotypic covariance matrices (P), including the degree of shared structure, the distribution of strengths of pair-wise correlations between traits, the degree of morphological integration of traits, and the ranks of matricies, between central and marginal populations of three species-pairs of coral reef fishes. Greater structural differences in P were observed between populations close to range margins and conspecific populations toward range centres, than between pairs of conspecific populations that were both more centrally located within their ranges. Approximately 80% of all pair-wise trait correlations within populations were greater in the north, but these differences were unrelated to the position of the sampled population with respect to the geographic range of the species. Neither the degree of morphological integration, nor ranks of P, indicated greater evolutionary constraint at range edges. Characteristics of P observed here provide no support for constraint contributing to the formation of these species' borders, but may instead reflect structural change in P caused by selection or drift, and their potential to evolve in the future.

  8. Nuclear risk behind the border?

    International Nuclear Information System (INIS)

    Varjoranta, T.

    1995-01-01

    The condition of nuclear wastes and facilities in Russia and in the Baltic countries arouses concern in Finland. Russia has two large nuclear power plants, nuclear weapons, over 300 nuclear submarine reactors and more than ten icebreaker reactors in close proximity to Finland's eastern border. The Lithuanian Ingalina nuclear power plant is also situated close to Finland. Following the Chernobyl accident, considerable improvements have been made to the technology and safety culture of Russian nuclear power plants, for instance, through international support programmes. The unstable social climate in Russia is, however, slowing progress down. Yet it is certain that no accident in the power plants near Finland's borders would cause immediate health risks in Finland, or would threaten the health of large numbers of people in the long term, either. Russia has not always taken proper care of its nuclear waste. In particular, spent fuel from nuclear submarines stored in Northern Russia causes problems. Russians have disposed of some waste by dumping ship reactors, with their fuel, into the Arctic Ocean. Some nuclear-powered submarines have sunk with all their crew. Russia has also conducted many nuclear tests in the vicinity of Finland. (orig.)

  9. Border Crossing/Entry Data - Border Crossing/Entry Data Time Series tool

    Data.gov (United States)

    Department of Transportation — The dataset is known as “Border Crossing/Entry Data.” The Bureau of Transportation Statistics (BTS) Border Crossing/Entry Data provides summary statistics to the...

  10. International Issues, High-Stakes Testing, and Border Pedagogy: Social Studies at Border High School

    Science.gov (United States)

    Cashman, Timothy G.; McDermott, Benjamin R.

    2013-01-01

    A recently constructed border wall stands within walking distance of Border High School (BHS) and was created to impede the flow of people, goods, fauna, and contraband from Mexico into the United States (U.S.). The reality, however, is that this geopolitical border is fluid, allowing connections between sociopolitical zones. The researchers…

  11. The Intersectionality of Border Pedagogy and Latino/a Youth: Enacting Border Pedagogy in Multiple Spaces

    Science.gov (United States)

    Ramirez, Pablo C.; Ross, Lydia; Jimenez-Silva, Margarita

    2016-01-01

    In this one-year qualitative study, the authors examined how border pedagogy is enacted by two Latino/a high school teachers in a border community in Southern California. Through classroom observations, the authors documented powerful student discussions that named complex borders (Giroux, 1992) that existed in their daily lives. We drew from…

  12. Entry of a Six-Residue Antimicrobial Peptide Derived from Lactoferricin B into Single Vesicles and Escherichia coli Cells without Damaging their Membranes.

    Science.gov (United States)

    Moniruzzaman, Md; Islam, Md Zahidul; Sharmin, Sabrina; Dohra, Hideo; Yamazaki, Masahito

    2017-08-22

    Lactoferricin B (LfcinB) and shorter versions of this peptide have antimicrobial activity. However, the elementary processes of interactions of these peptides with lipid membranes and bacteria are still not well understood. To elucidate the mechanism of their antimicrobial activity, we investigated the interactions of LfcinB (4-9) (its sequence of RRWQWR) with Escherichia coli cells and giant unilamellar vesicles (GUVs). LfcinB (4-9) and lissamine rhodamine B red-labeled LfcinB (4-9) (Rh-LfcinB (4-9)) did not induce an influx of a membrane-impermeant fluorescent probe, SYTOX green, from the outside of E. coli cells into their cytoplasm, indicating that no damage occurred in their plasma membrane. To examine the activity of LfcinB (4-9) to enter E. coli cytoplasm, we investigated the interaction of Rh-LfcinB (4-9) with single cells of E. coli containing calcein using confocal microscopy. We found that Rh-LfcinB (4-9) entered the cytoplasm without leakage of calcein. Next, we investigated the interactions of Rh-LfcinB (4-9) with single GUVs of dioleoylphosphatidylglycerol (DOPG) and dioleoylphosphatidylcholine (DOPC) mixtures containing a fluorescent probe, Alexa Fluor 647 hydrazide (AF647), using the single GUV method. The results indicate that Rh-LfcinB (4-9) outside the GUV translocated through the GUV membrane and entered its lumen without leakage of AF647. Interaction of Rh-LfcinB (4-9) with DNA increased its fluorescence intensity greatly. Therefore, we can conclude that Rh-LfcinB (4-9) can translocate across lipid membrane regions of the plasma membrane of E. coli cells to enter their cytoplasm without leakage of calcein and its antimicrobial activity is not due to damage of their plasma membranes.

  13. Residual nilpotence and residual solubility of groups

    International Nuclear Information System (INIS)

    Mikhailov, R V

    2005-01-01

    The properties of the residual nilpotence and the residual solubility of groups are studied. The main objects under investigation are the class of residually nilpotent groups such that each central extension of these groups is also residually nilpotent and the class of residually soluble groups such that each Abelian extension of these groups is residually soluble. Various examples of groups not belonging to these classes are constructed by homological methods and methods of the theory of modules over group rings. Several applications of the theory under consideration are presented and problems concerning the residual nilpotence of one-relator groups are considered.

  14. Infectious Disease Border Issues Conference: Meeting Synopsis

    Science.gov (United States)

    2012-04-03

    methicillin - resistant Staphylococcus aureus (MRSA). Operation MECACAR 1998 was highlighted as a successful example of cross-border coordination...training courses, no joint public health investigation teams) and illegal animal transportation across borders were identified as some of the existing...Work (2007), including fostering global partnerships; strengthening public health security in travel and transport ; improving the WHO global alert

  15. Sprouting of dormant buds on border trees

    Science.gov (United States)

    G.R., Jr. Trimble; H. Clay Smith; H. Clay Smith

    1970-01-01

    As part of an evaluation of silvicultura1 systems used in managing Appalachian hardwoods, we are studying degrade of border trees surrounding harvest-cut openings made in the patch cutting and group selection systems. One facet of this research dealt with determining what portion of visually evident dormant buds on border tree boles sprouted when the openings were cut...

  16. Green Belt Europe - borders separate, nature unites

    Science.gov (United States)

    Uwe Friedel

    2015-01-01

    During the period of the Cold War between 1945 and 1989, a "Green Belt" of valuable pristine landscapes developed along the border line between Eastern and Western Europe, the intensively fortified and guarded so called Iron Curtain. Due to the remoteness of the border areas, a high number of national parks and other large conservation areas can be found...

  17. Residue specific hydration of primary cell wall potato pectin identified by solid-state 13C single-pulse MAS and CP/MAS NMR spectroscopy

    DEFF Research Database (Denmark)

    Larsen, Flemming Hofmann; Chrestensen, Inge Byg; Damager, Iben

    2011-01-01

    Hydration of rhamnogalacturonan-I (RG-I) derived from potato cell wall was analyzed by 13C single-pulse (SP) magic-angle-spinning (MAS) and 13C cross-polarization (CP) MAS nuclear magnetic resonance (NMR) and supported by 2H SP/MAS NMR experiments. The study shows that the arabinan side chains...... hydrate more readily than the galactan side chains and suggests that the overall hydration properties can be controlled by modifying the ratio of these side chains. Enzymatic modification of native (NA) RG-I provided samples with reduced content of arabinan (sample DA), galactan (sample DG), or both side...... chains (sample DB). Results of these samples suggested that hydration properties were determined by the length and character of the side chains. NA and DA exhibited similar hydration characteristics, whereas DG and DB were difficult to hydrate because of the less hydrophilic properties of the rhamnose...

  18. Border Encounters: American Cultural Politics and the U.S.-Mexico Border

    OpenAIRE

    Reimer, Jennifer Andrea

    2011-01-01

    AbstractBorder Encounters: American Cultural Politics and the U.S.-Mexico BorderbyJennifer Andrea ReimerDoctor of Philosophy in Ethnic StudiesUniversity of California, BerkeleyProfessor José David Saldívar, Co-ChairProfessor Laura E. Pérez, Co-ChairBorder Encounters: American Cultural Politics and the U.S.-Mexico Border is a transnational, interdisciplinary cultural study of the contemporary U.S.-Mexico border that argues for the critical role of the international border in the racial past, p...

  19. Revitalising Borders: Memory, Mobility and Materiality in a Latvian-Russian Border Region

    Directory of Open Access Journals (Sweden)

    Aija Lulle

    2016-04-01

    Full Text Available In this paper I investigate how an international border is 'revitalised' in political discourses as opposed to lived experiences. Based on narratives I have collected from border dwellers on both sides of the current border between Latvia and Rus-sia and placing them into a broader context of current border debates, I analyse how geographical and social mobility is remembered from Soviet times and reworked in current contexts. I argue that while politically the border is revitalised through aban-doning and forgetting the Soviet past and through the idea of constant threats in the future, locally it is revitalised through giving a life to the abandoned: memories of 'vigorous times' in life-courses and material things. People who dwell at the border did not move themselves: the international border moved several times in one cen-tury leaving border dwellers' memories and significant places on the 'other' side. I focus on how these borders were crossed in the past, how they are (not crossed now, and the social meanings assigned to these circumstances. In the current con-text I follow diverse paths of reasoning that describe how the uneven flow of goods and people through the Latvian-Russian border shapes the power dynamic against which the people living in the border area used to reconstruct imaginaries of 'Soviet times' versus 'Europe' and 'vigorous times' versus decline.

  20. Single residue AAV capsid mutation improves transduction of photoreceptors in the Abca4-/- mouse and bipolar cells in the rd1 mouse and human retina ex vivo.

    Science.gov (United States)

    De Silva, Samantha R; Charbel Issa, Peter; Singh, Mandeep S; Lipinski, Daniel M; Barnea-Cramer, Alona O; Walker, Nathan J; Barnard, Alun R; Hankins, Mark W; MacLaren, Robert E

    2016-11-01

    Gene therapy using adeno-associated viral (AAV) vectors for the treatment of retinal degenerations has shown safety and efficacy in clinical trials. However, very high levels of vector expression may be necessary for the treatment of conditions such as Stargardt disease where a dual vector approach is potentially needed, or in optogenetic strategies for end-stage degeneration in order to achieve maximal light sensitivity. In this study, we assessed two vectors with single capsid mutations, rAAV2/2(Y444F) and rAAV2/8(Y733F) in their ability to transduce retina in the Abca4 -/- and rd1 mouse models of retinal degeneration. We noted significantly increased photoreceptor transduction using rAAV2/8(Y733F) in the Abca4 -/- mouse, in contrast to previous work where vectors tested in this model have shown low levels of photoreceptor transduction. Bipolar cell transduction was achieved following subretinal delivery of both vectors in the rd1 mouse, and via intravitreal delivery of rAAV2/2(Y444F). The successful use of rAAV2/8(Y733F) to target bipolar cells was further validated on human tissue using an ex vivo culture system of retinal explants. Capsid mutant AAV vectors transduce human retinal cells and may be particularly suited to treat retinal degenerations in which high levels of transgene expression are required.

  1. Characterization of individual ice residual particles by the single droplet freezing method: a case study in the Asian dust outflow region

    Science.gov (United States)

    Iwata, Ayumi; Matsuki, Atsushi

    2018-02-01

    pure or fresh calcite, Ca(NO3)2, and (NH4)2SO4 particles were more often found in the non-active fraction. In this study, we demonstrated the capability of the combined single droplet freezing method and thorough individual particle analysis to characterize the ice nucleation activity of atmospheric aerosols. We also found that dramatic changes in the particle mixing states during long-range transport had a complex effect on the ice nucleation activity of the host aerosol particles. A case study in the Asian dust outflow region highlighted the need to consider particle mixing states, which can dramatically influence ice nucleation activity.

  2. Characterization of individual ice residual particles by the single droplet freezing method: a case study in the Asian dust outflow region

    Directory of Open Access Journals (Sweden)

    A. Iwata

    2018-02-01

    dust particles. Also, relatively pure or fresh calcite, Ca(NO32, and (NH42SO4 particles were more often found in the non-active fraction. In this study, we demonstrated the capability of the combined single droplet freezing method and thorough individual particle analysis to characterize the ice nucleation activity of atmospheric aerosols. We also found that dramatic changes in the particle mixing states during long-range transport had a complex effect on the ice nucleation activity of the host aerosol particles. A case study in the Asian dust outflow region highlighted the need to consider particle mixing states, which can dramatically influence ice nucleation activity.

  3. Why Sociology Is Silent Concerning Borders

    Directory of Open Access Journals (Sweden)

    S.E. Nikolov

    2015-08-01

    Full Text Available Border in sociological sense means a barrier that separates social groups, strata, their values, and the difference between ways of life between particular social groups. Such groups may be separated by many dividing lines, or borders: social/living conditions, opportunities/prospects, legal rights/customs, viewpoints, and so on. Sometimes mobility does not permit other than individual, or small-group, crossing of these borders. It seems really strange why border topic is almost completely absent from the sociology. It is so pertinent to the fate and shaping of various social groups, depending from the location of the border. We think of a boundary whenever we think of an entity demarcated from its surroundings. Events, too, have boundaries – temporal ones: their beginning, climax, final. All our lives are bounded in the continuum between our births and our deaths. A philosopher would imply also that even imaginary, abstract entities, such as concepts or layouts, have boundaries of their own. One may say that condition for all this boundary/border talk is coherent, and whether it reproduces the world around us’ structure, or the organizing activity of our intellect, are matters of deep philosophical controversy. Borders are difficult to disappear totally even within the European Union, providing some obstacles to the freedom of movement to those left still outside the Schengen agreement.

  4. Languaging the Borders of Europe

    Directory of Open Access Journals (Sweden)

    Olivier Kramsch

    2015-11-01

    Full Text Available Emerging from a discomfort with the blind spots encountered within and across theorizations of language and space in the field of human geography, in this article, we argue for “making space” for conceptualizations that speak from and through the everyday territories of migrants in Europe today. Inspired by a range of writers thinking postcolonially and multi/trans-lingually, the authors draw on their own embodied migrant experience to argue for re-envisioning Europe’s borders through multiple languaging practices. “Languaging”, in this view, takes linguistic practices in a migrant context as an inherently prosthetic activity, whereby any dominant, national host language is inevitably subject to the subterranean rumblings of all the languages a migrant brings with her on her global journeys. Conceived as being saturated with prosthetic “absence(s”, migrant languaging practices rework cultural geography’s bounded, inward-looking, and security-fixated understanding of the language/territory nexus, the better to open a vital space for re-envisioning language’s everyday territories as sites for translational solidarity and becoming.

  5. Borders, boundaries and desirable wishes

    Directory of Open Access Journals (Sweden)

    Luca Pinciaroli

    2015-05-01

    Full Text Available “Borders, boundaries and desirable wishes” is the title of the residential workshop offered to a group of young adults (aged 18-25 of the Centro di Salute Mentale (Mental Health Center of the DSM Basaglia of ASL TO2 in Turin. The idea of the workshop, the definition of the objectives and the topics, which are clearly expressed in the title, come from the work of the team dedicated to group psychotherapies, which has been offering group psychodrama sessions to young adults of this age since 2008. In the delicate move to the adult age, these young adults are lost and stuck in static realities where it is not possible to open up to the dimension of desire nor to the transforming encounter with the Other, since they didn’t have the experience of boundaries and lack. These two elements are necessary to acquire the ability to make projects for oneself. During the workshop the following instruments were used: group, psychodrama and art therapy. The group, as a paternal function, ensured the presence of safe boundaries enabling individuals to experiment; psychodrama and art therapy enabled the bodies to experience encounters and transformations, using doing as a metaphor for the movement against the inhibition of doing and as a way to show oneself to the Other and be able to see the Other. 

  6. Cross-border shopping and tourism destination marketing

    DEFF Research Database (Denmark)

    Makkonen, Teemu

    2016-01-01

    This article addresses the economic impact that cross-border shopping has on the local tourism industry and the ways that cross-border shopping is taken advantage of in tourism destination marketing. Southern Jutland–situated in Denmark just north of the German border, where border shops situated......-border shopping into tourism destination marketing strategies. The results have wider relevance for other border regions.......This article addresses the economic impact that cross-border shopping has on the local tourism industry and the ways that cross-border shopping is taken advantage of in tourism destination marketing. Southern Jutland–situated in Denmark just north of the German border, where border shops situated...... just south of the same border enable Danes to capitalize on the lower value added tax levels in Germany–is utilized as an illustrative case example. The data was collected by analysing the relevant tourism destination marketing material and via interviews with local destination marketing organizations...

  7. Borders as barriers to tourism: tourists experiences at the Beitbridge Border Post (Zimbabwean side

    Directory of Open Access Journals (Sweden)

    Getrude Kwanisai

    2014-01-01

    Full Text Available International borders greatly influence tourism development. In 2012 and 2013, a decline in tourists to Zimbabwe from South Africa was partially attributed to tourist border facilitation issues. It is against this background that this study sought to establish the nature of challenges faced by tourists when using the Beitbridge border post (Zimbabwean side. Questionnaire responses were thematically analysed and the study concluded that border administrative management related issues are a major barrier to tourism. Key among the study's recommendations is that the depressed tourists' border experiences obtaining at Beitbridge border post among other constraints have to be addressed as a matter of urgency. This will enhance Zimbabwe's accessibility, tourist satisfaction and the image of the country as a destination. The paper further identifies several destination managerial implications and future research priorities.

  8. The Migrant Border Crossing Study: A methodological overview of research along the Sonora-Arizona border.

    Science.gov (United States)

    Martínez, Daniel E; Slack, Jeremy; Beyerlein, Kraig; Vandervoet, Prescott; Klingman, Kristin; Molina, Paola; Manning, Shiras; Burham, Melissa; Walzak, Kylie; Valencia, Kristen; Gamboa, Lorenzo

    2017-07-01

    Increased border enforcement efforts have redistributed unauthorized Mexican migration to the United States (US) away from traditional points of crossing, such as San Diego and El Paso, and into more remote areas along the US-Mexico border, including southern Arizona. Yet relatively little quantitative scholarly work exists examining Mexican migrants' crossing, apprehension, and repatriation experiences in southern Arizona. We contend that if scholars truly want to understand the experiences of unauthorized migrants in transit, such migrants should be interviewed either at the border after being removed from the US, or during their trajectories across the border, or both. This paper provides a methodological overview of the Migrant Border Crossing Study (MBCS), a unique data source on Mexican migrants who attempted an unauthorized crossing along the Sonora-Arizona border, were apprehended, and repatriated to Nogales, Sonora in 2007-09. We also discuss substantive and theoretical contributions of the MBCS.

  9. Conservative Libertarianism and the Ethics of Borders

    Directory of Open Access Journals (Sweden)

    Enrique Camacho Beltran

    2015-06-01

    Full Text Available Many conservatives endorse a defence of closed borders grounded in basic liberal rights such as the basic right of association. Some conservatives also endorse libertarian principles of legitimacy. It is not clear though that this sort of defence of closed borders is somehow coherent with these libertarian ideals. I argue that conservative libertarians of this kind must reject this defence of closed borders because either it collapses into a form of statism incoherent with libertarian principles of legitimacy, or into an ideal precept without appeal regarding reality in the here and now that could only be applied to changing the very nature of the societies we know. As a result, at least conservative libertarians need to find a different source of justification for closed borders.

  10. Abuses at Europe’s borders

    Directory of Open Access Journals (Sweden)

    Duncan Breen

    2016-01-01

    Full Text Available Refugees and migrants have been regularly subjected to widespread rights violations by officials at some European borders. The EU needs to allow more legal avenues for people seeking protection to reach Europe safely.

  11. Measuring cross-border regional STI integration

    Energy Technology Data Exchange (ETDEWEB)

    Makkonen, T

    2016-07-01

    Earlier quantitative studies on cross-border regional integration processes have commonly neglected science, technology and innovation (STI) indicators: even the most notable example of a composite indicator approach to measuring cross-border regional integration, i.e. the Oresund index, lacks a sub-category for STI. Consequently, by ignoring cross-border innovation and knowledge flows, the Oresund integration index fails to take into account one of the most important drivers of economic growth in cross-border regions. Therefore, a new composite STI indicator (sub-category) was introduced to strengthen the Oresund integration index. This was compiled from patent, publication and collaborative R&D project data. The findings show that this index performs reasonably well in depicting STI integration, while at the same time remaining simple and straightforward enough to be adopted in other crossborder regions. (Author)

  12. Nuclear security at Zimbabwe’s borders

    International Nuclear Information System (INIS)

    Dahlstrom, Danielle

    2016-01-01

    Enhancing detection capabilities at the Victoria Falls border crossing provides confidence to people visiting Zimbabwe that measures are in place to prevent disruption caused by radioactive materials and helps to protect the local environment.

  13. The development of cross-border economic relations

    NARCIS (Netherlands)

    van Houtum, H.J.

    1998-01-01

    This dissertation investigates the influence of a state border on the development of cross-border economic relations in the European Union. The focus is on the frequency, number, and success of cross-border relations between firms in the border regions of the Netherlands and Belgium. The study fills

  14. Detection of metal residues on bone using SEM-EDS. Part I: Blunt force injury.

    Science.gov (United States)

    Pechníková, Markéta; Porta, Davide; Mazzarelli, Debora; Rizzi, Agostino; Drozdová, Eva; Gibelli, Daniele; Cattaneo, Cristina

    2012-11-30

    Previous studies have indicated that metal particles remain on bone after sharp force injury or gunshot and that their detection by scanning electron microscopy with energy dispersive X-ray spectrometry (SEM-EDS) could greatly help in tool identification. However, the presence of metal particles on bone surfaces in the context of blunt force trauma has never been assessed experimentally. For this reason the present paper represents an experimental study of the behaviour of metal residues on bone following blunt force injury. Ten fresh sub-adult bovine metatarsal bones were manually cleaned of soft tissues. They were then struck by metal bars (copper, iron or aluminium) on the external surface of the mid-diaphysis. All blunt metal instruments used in this study left a sign in the form of single particles, a smear or a powder-like deposit on the bone surface. The residues of all three metal implements were detected on the bone surface, 0.3-10 mm from the fracture border. The presence of metal particles was confirmed in all samples struck with iron and copper and in two of six aluminium samples; no particles were detected on the negative control. Chemical composition of residues highly corresponded with the composition of applied bars. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  15. The California Border Health Collaborative: A Strategy for Leading the Border to Better Health

    Directory of Open Access Journals (Sweden)

    Charles Edwards Matthews III

    2015-05-01

    Full Text Available There are hundreds of departments and organizations working on border health issues in the California/Baja California border region trying to protect and improve health without a collaborative structure that integrates jurisdictions and organizations. As a result, there is a need to effectively improve the health in the border region by coordinating these organizations to work together and benefit from each other’s best practices. The newly developed California Border Health Collaborative (CBHC can provide the leadership and collaborative culture to positively improve the health of the border region. This article aims to describe the development process of this collaborative to include key ingredients to success, the roles of mulit-level jurisdictions, and policy implications.This article describes the methods used to develop key aspects of collaborative leadership, strategic alignment and a common vision toward the building of this collective impact approach to border health. In addition, we describe the role of key local County (County of San Diego Live Well San Diego initiative, State, (California Department of Public Health- Office of Binational Border Health, Federal (US-Mexico Border Health Commission’s Leaders across Borders, Academia (e.g., University of California San Diego and San Diego State University and non-profit entities (e.g., Project Concern International, San Ysidro Health Center in forming the BHCC. Evaluating the consortium development process included a literature review of similar processes, a review of internal documents and an analysis of developmental events. To this point the CBHC has built a strong, cohesive collaborative on the U.S. side of the border. It is sharing and leveraging local expertise to address many border health issues. Even more importantly, the BHCC has reached a key stage in which it can effectively engage its Baja California, Mexico counterparts in a manner that will prove extremely powerful

  16. Single histidine residue in head-group region is sufficient to impart remarkable gene transfection properties to cationic lipids: evidence for histidine-mediated membrane fusion at acidic pH.

    Science.gov (United States)

    Kumar, V V; Pichon, C; Refregiers, M; Guerin, B; Midoux, P; Chaudhuri, A

    2003-08-01

    Presence of endosome-disrupting multiple histidine functionalities in the molecular architecture of cationic polymers, such as polylysine, has previously been demonstrated to significantly enhance their in vitro gene delivery efficiencies. Towards harnessing improved transfection property through covalent grafting of endosome-disrupting single histidine functionality in the molecular structure of cationic lipids, herein, we report on the design, the synthesis and the transfection efficiency of two novel nonglycerol-based histidylated cationic amphiphiles. We found that L-histidine-(N,N-di-n-hexadecylamine)ethylamide (lipid 1) and L-histidine-(N,N-di-n-hexadecylamine,-N-methyl)ethylamide (lipid 2) in combination with cholesterol gave efficient transfections into various cell lines. The transfection efficiency of Chol/lipid 1 lipoplexes into HepG2 cells was two order of magnitude higher than that of FuGENE(TM)6 and DC-Chol lipoplexes, whereas it was similar into A549, 293T7 and HeLa cells. A better efficiency was obtained with Chol/lipid 2 lipoplexes when using the cytosolic luciferase expression vector (pT7Luc) under the control of the bacterial T7 promoter. Membrane fusion activity measurements using fluorescence resonance energy transfer (FRET) technique showed that the histidine head-groups of Chol/lipid 1 liposomes mediated membrane fusion in the pH range 5-7. In addition, the transgene expression results using the T7Luc expression vector convincingly support the endosome-disrupting role of the presently described mono-histidylated cationic transfection lipids and the release of DNA into the cytosol. We conclude that covalent grafting of a single histidine amino acid residue to suitable twin-chain hydrophobic compounds is able to impart remarkable transfection properties on the resulting mono-histidylated cationic amphiphile, presumably via the endosome-disrupting characteristics of the histidine functionalities.

  17. Radiation safety without borders initiative

    International Nuclear Information System (INIS)

    Dibblee, Martha; Dickson, Howard; Krieger, Ken; Lopez, Jose; Waite, David; Weaver, Ken

    2008-01-01

    The Radiation Safety Without Borders (RSWB) initiative provides peer support to radiation safety professionals in developing countries, which bolsters the country's infrastructure and may lead the way for IRPA Associate membership. The Health Physics Society (HPS) recognizes that many nations do not possess the infrastructure to adequately control and beneficially use ionizing radiation. In a substantial number of countries, organized radiation protection programs are minimal. The RSWB initiative relies on HPS volunteers to assist their counterparts in developing countries with emerging health physics and radiation safety programs, but whose resources are limited, to provide tools that promote and support infrastructure and help these professionals help themselves. RSWB experience to date has shown that by providing refurbished instruments, promoting visits to a HPS venue, or visiting a country just to look provide valuable technical and social infrastructure experiences often missing in the developing nation's cadre of radiation safety professionals. HPS/RSWB with the assistance of the International Atomic Energy Agency (IAEA) pairs chapters with a country, with the expectation that the country's professional radiation safety personnel will form a foreign HPS chapter, and the country eventually will become an IRPA Associate. Although still in its formative stage, RSWB nonetheless has gotten valuable information in spite of the small number of missions. The RSWB initiative continues to have significant beneficial impacts, including: Improving the radiation safety infrastructure of the countries that participate; Assisting those countries without professional radiation safety societies to form one; Strengthening the humanitarian efforts of the United States; Enhancing Homeland Security efforts through improved control of radioactive material internationally. Developing countries, including those in Latin America, underwritten by IAEA, may take advantage of resources

  18. Decision Model for U.S.- Mexico Border Security Measures

    Science.gov (United States)

    2017-09-01

    missions that the I&A focuses on is, “border security, including narcotics smuggling, alien and human smuggling, and money laundering ...and money assigned to border security investments. 14. SUBJECT TERMS Department of Homeland Security (DHS), border security, U.S.–Mexico border...and money assigned to border security investments. vi THIS PAGE INTENTIONALLY LEFT BLANK vii TABLE OF CONTENTS I. INTRODUCTION

  19. Creditor protection in cross-border mergers; unfinished business

    Directory of Open Access Journals (Sweden)

    Geert T.M.J. Raaijmakers

    2008-03-01

    Full Text Available In cross-border mergers, creditor protection is important to facilitate a smooth, efficient and transparent process necessary to facilitate the single market. As all assets and liabilities are being transferred and there is a risk that the liabilities of the acquiring company will exceed the assets, creditor protection needs to be safeguarded in legal mergers. As the title suggests, creditor protection in the context of cross-border mergers and the recently adopted directive is examined in this paper, as well as the position of creditors under Dutch law and the Third Directive. The ex-ante and ex-post systems of creditor protection, both existing in the Member States of the EU, and which are both supported by strong arguments, are also discussed. The fact that differences in creditor protection rules nevertheless remain may create unjustifiable differences in the position of various groups of creditors involved in one single cross-border merger. The authors conclude that the case for leaving creditor protection to the Member States is weakening. Differences in national legislation on creditor protection, defendable as they may be, are ultimately of a technical nature and create unnecessary and unjustifiable impediments. There are strong arguments, in other words, to adopt the same provisions for all transactions for the sake of simplicity, but while this may be attractive, it can lead to undesired delay. Amending the Directive at this point in time thus seems equally unfeasible. This stresses the need to make haste with at least some further harmonization of creditor protection rules related to the Third Directive.

  20. Myocardial blood flow rate and capillary permeability for 99mTc-DTPA in patients with angiographically normal coronary arteries. Evaluation of the single-injection, residue detection method with intracoronary indicator bolus injection and the use of a mobile gamma camera

    DEFF Research Database (Denmark)

    Svendsen, Jesper Hastrup; Kelbaek, H; Efsen, F

    1994-01-01

    The aims of the present study were to quantitate myocardial perfusion and capillary permeability in the human heart by means of the single-injection, residue detection method using a mobile gamma camera. With this method, the intravascular mean transit time and the capillary extraction fraction (E...

  1. Organizing cross-border fire brigade response in the Dutch-German border region

    NARCIS (Netherlands)

    Boersma, F.K.; Engelman, E.

    2012-01-01

    This article addresses the opportunities and problems with cross-border collaboration between the Dutch and German fire brigades. The following are the main problems: 1) no uniformity in concluding and using the cross-border agreements for emergency assistance, 2) the language problem, 3) the

  2. Regional Joint Border Commands: A Pathway to Improving Collaboration and Effectiveness for Border Control

    Science.gov (United States)

    2009-12-01

    Police xii SBI Secure Border Initiative SES Senior Executive Service SSP Secretaria de Seguridad Publica TSA Transportation Security...also been involvement from the Mexican law enforcement agency, Secretaria de Seguridad Publica (SSP) on the southwest border (CBP, 2009; ICE, 2009, p. 5

  3. Measuring cross-border travel times for freight : Otay Mesa international border crossing.

    Science.gov (United States)

    2010-09-01

    Cross border movement of people and goods is a vital part of the North American economy. Accurate real-time data on travel times along the US-Mexico border can help generate a range of tangible benefits covering improved operations and security, lowe...

  4. Small Border Traffic and Cross-Border Tourism Between Poland and the Kaliningrad Oblast of the Russian Federation

    OpenAIRE

    Anisiewicz Renata; Palmowski Tadeusz

    2014-01-01

    Polish and Russian cross-border cooperation is governed by lawful agreements. The enlargement of the Schengen Area had a significant impact on Kaliningrad Oblast relations and cross-border cooperation with its neighbours. The introduction of visas between Poland and Russia hindered and restricted local border trade which had for years been the only measure mitigating social and economic problems of the cross-border regions. Nevertheless, border traffic between Poland and Kaliningrad grew stea...

  5. Network communities within and across borders.

    Science.gov (United States)

    Cerina, Federica; Chessa, Alessandro; Pammolli, Fabio; Riccaboni, Massimo

    2014-04-01

    We investigate the impact of borders on the topology of spatially embedded networks. Indeed territorial subdivisions and geographical borders significantly hamper the geographical span of networks thus playing a key role in the formation of network communities. This is especially important in scientific and technological policy-making, highlighting the interplay between pressure for the internationalization to lead towards a global innovation system and the administrative borders imposed by the national and regional institutions. In this study we introduce an outreach index to quantify the impact of borders on the community structure and apply it to the case of the European and US patent co-inventors networks. We find that (a) the US connectivity decays as a power of distance, whereas we observe a faster exponential decay for Europe; (b) European network communities essentially correspond to nations and contiguous regions while US communities span multiple states across the whole country without any characteristic geographic scale. We confirm our findings by means of a set of simulations aimed at exploring the relationship between different patterns of cross-border community structures and the outreach index.

  6. Cross-Border Mergers and Market Segmentation (Replaces TILEC DP 2010-035)

    NARCIS (Netherlands)

    Ray Chaudhuri, A.

    2011-01-01

    This paper shows that cross-border mergers are more likely to occur in industries which serve multiple segmented markets rather than a single integrated market, given that cost functions are strictly convex. The product price rises in the market where an acquisition is made but falls in the other,

  7. Cross-Border Mergers and Market Segmentation (Replaces CentER DP 2010-096)

    NARCIS (Netherlands)

    Ray Chaudhuri, A.

    2011-01-01

    This paper shows that cross-border mergers are more likely to occur in industries which serve multiple segmented markets rather than a single integrated market, given that cost functions are strictly convex. The product price rises in the market where an acquisition is made but falls in the other,

  8. Advancing Border Pedagogies: Understandings of Citizenship through Comparisons of Home to School Contexts

    Science.gov (United States)

    Salinas, Cinthia; Vickery, Amanda E.; Franquiz, Maria

    2016-01-01

    Border pedagogies recognize citizenship as a contentious privilege afforded to some but not others. In reconciling the multiple and often conflicting renditions of citizen/ citizenship, this qualitative single case study found that preservice teachers benefit from examining the great civic divide between home and school and in confronting spaces…

  9. Cross-border regional innovation system integration

    DEFF Research Database (Denmark)

    Makkonen, Teemu; Weidenfeld, Adi; Williams, Allan

    2017-01-01

    The importance of inter-regional cooperation and innovation are widely accepted in the development rhetoric of the European Union. The highlighted importance of both themes in the context of borderlands has recently led to the coining of a new concept, cross-border regional innovation system...... of cross-border cooperation in a regional innovation system setting. The framework was further tested with illustrative empirical cases that demonstrate its feasibility........ However, little attention has been given to the empirical analysis of the concept. This paper suggests a framework for empirically validating the concept by examining the levels of integration between cross-border regions. The outcome is a proposed framework can be operationalized by measurable indicators...

  10. BTFS: The Border Trade Facilitation System

    Energy Technology Data Exchange (ETDEWEB)

    Phillips, L.R.

    1999-03-18

    The author demonstrates the Border Trade Facilitation System (BTFS), an agent-based bilingual e-commerce system built to expedite the regulation, control, and execution of commercial trans-border shipments during the delivery phase. The system was built to serve maquila industries at the US/Mexican border. The BTFS uses foundation technology developed here at Sandia Laboratories' Advanced Information Systems Lab (AISL), including a distributed object substrate, a general-purpose agent development framework, dynamically generated agent-human interaction via the World-Wide Web, and a collaborative agent architecture. This technology is also the substrate for the Multi-Agent Simulation Management System (MASMAS) proposed for demonstration at this conference. The BTFS executes authenticated transactions among agents performing open trading over the Internet. With the BTFS in place, one could conduct secure international transactions from any site with an Internet connection and a web browser. The BTFS is currently being evaluated for commercialization.

  11. Use of border information in the classification of mammographic masses

    International Nuclear Information System (INIS)

    Varela, C; Timp, S; Karssemeijer, N

    2006-01-01

    We are developing a new method to characterize the margin of a mammographic mass lesion to improve the classification of benign and malignant masses. Towards this goal, we designed features that measure the degree of sharpness and microlobulation of mass margins. We calculated these features in a border region of the mass defined as a thin band along the mass contour. The importance of these features in the classification of benign and malignant masses was studied in relation to existing features used for mammographic mass detection. Features were divided into three groups, each representing a different mass segment: the interior region of a mass, the border and the outer area. The interior and the outer area of a mass were characterized using contrast and spiculation measures. Classification was done in two steps. First, features representing each of the three mass segments were merged into a neural network classifier resulting in a single regional classification score for each segment. Secondly, a classifier combined the three single scores into a final output to discriminate between benign and malignant lesions. We compared the classification performance of each regional classifier and the combined classifier on a data set of 1076 biopsy proved masses (590 malignant and 486 benign) from 481 women included in the Digital Database for Screening Mammography. Receiver operating characteristic (ROC) analysis was used to evaluate the accuracy of the classifiers. The area under the ROC curve (A z ) was 0.69 for the interior mass segment, 0.76 for the border segment and 0.75 for the outer mass segment. The performance of the combined classifier was 0.81 for image-based and 0.83 for case-based evaluation. These results show that the combination of information from different mass segments is an effective approach for computer-aided characterization of mammographic masses. An advantage of this approach is that it allows the assessment of the contribution of regions rather

  12. Externalization and Border-induced Displacement

    DEFF Research Database (Denmark)

    Lemberg-Pedersen, Martin

    seeking children in Denmark is assessed as a form of liberal nationalism. Several problematic features with this system are discussed, such as the lacking Danish implementation of the Convention of the Rights of the Child, and the use of cultural generalizations in case evaluations. Chapter four conducts...... and the international banking sector all have overlapping interests in privatized border control. Chapter five identifies the multiple flows, technological, personnel, funds and data, maintaining Europe’s border infrastructure, As migrants are circulated between detention camps and countries, dumped in deserts...

  13. DIRECT TUNNELLING AND MOSFET BORDER TRAPS

    Directory of Open Access Journals (Sweden)

    Vladimir Drach

    2015-09-01

    Full Text Available The border traps, in particular slow border traps, are being investigated in metal-oxide-semiconductor structures, utilizing n-channel MOSFET as a test sample. The industrial process technology of test samples manufacturing is described. The automated experimental setup is discussed, the implementation of the experimental setup had made it possible to complete the entire set of measurements. The schematic diagram of automated experimental setup is shown. The charging time characteristic of the ID-VG shift reveals that the charging process is a direct tunnelling process and highly bias dependent.

  14. Cross-border regional innovation systems

    DEFF Research Database (Denmark)

    Makkonen, Teemu; Rohde, Stephan

    2016-01-01

    . This paper discusses the reasons behind this mismatch which means that the concept still rests upon and draws policy suggestions based on a thin evidence base. Directions for further research are pointed out by underlining the need for holistic empirical validations of the concept together with the need......The concept of cross-border regional innovation systems (CBRIS) surfaced in the literature on economic geography through discourses that highlighted the need of broadening innovation systems to cross-border contexts. Since these early discussions, the theoretical backgrounds of CBRIS have been...

  15. Border installations: the experience of Wackersdorf

    International Nuclear Information System (INIS)

    Heller, K.

    1988-01-01

    Following the decision of the Government of the Federal Republic of Germany to construct a fuel reprocessing plant (in the wider context of organising radioactive waste disposal) at Wackersdorf, 130 km from the Austrian border, actions were brought against the German constructor before Austrian and German courts. The author describes the mechanisms governing administrative procedures in both countries and their connection with public international law. He analyses the legal argumentations developed before the different courts as well as the debate on the concept of territoriality and border installations (NEA) [fr

  16. Meteors Without Borders: a global campaign

    Science.gov (United States)

    Heenatigala, T.

    2012-01-01

    "Meteors Without Borders" is a global project, organized by Astronomers Without Borders and launched during the Global Astronomy Month in 2010 for the Lyrid meteor shower. The project focused on encouraging amateur astronomy groups to hold public outreach events for major meteor showers, conduct meteor-related classroom activities, photography, poetry and art work. It also uses social-media platforms to connect groups around the world to share their observations and photography, live during the events. At the International Meteor Conference 2011, the progress of the project was presented along with an extended invitation for collaborations for further improvements of the project.

  17. Dimeric assembly of enterocyte brush border enzymes

    DEFF Research Database (Denmark)

    Danielsen, E M

    1994-01-01

    The noncovalent, dimeric assembly of small intestinal brush border enzymes was studied by sedimentation analysis in density gradients of extracts of pulse-labeled pig jejunal mucosal explants. Like aminopeptidase N (EC 3.4.11.2), sucrase-isomaltase (EC 3.2.1.48-10), aminopeptidase A (EC 3...... appearance of the liposome-reconstituted enzyme [Norén et al. (1986) J. Biol. Chem. 261, 12306-12309], showing only the inner, membrane-anchored domains of the monomers to be in close contact with one another while the outer domains are far apart. In contrast to the other brush border enzymes studied...

  18. Leptogenesis and residual CP symmetry

    International Nuclear Information System (INIS)

    Chen, Peng; Ding, Gui-Jun; King, Stephen F.

    2016-01-01

    We discuss flavour dependent leptogenesis in the framework of lepton flavour models based on discrete flavour and CP symmetries applied to the type-I seesaw model. Working in the flavour basis, we analyse the case of two general residual CP symmetries in the neutrino sector, which corresponds to all possible semi-direct models based on a preserved Z 2 in the neutrino sector, together with a CP symmetry, which constrains the PMNS matrix up to a single free parameter which may be fixed by the reactor angle. We systematically study and classify this case for all possible residual CP symmetries, and show that the R-matrix is tightly constrained up to a single free parameter, with only certain forms being consistent with successful leptogenesis, leading to possible connections between leptogenesis and PMNS parameters. The formalism is completely general in the sense that the two residual CP symmetries could result from any high energy discrete flavour theory which respects any CP symmetry. As a simple example, we apply the formalism to a high energy S 4 flavour symmetry with a generalized CP symmetry, broken to two residual CP symmetries in the neutrino sector, recovering familiar results for PMNS predictions, together with new results for flavour dependent leptogenesis.

  19. Determination of C10-chloroalkane residues in fish matrices by short column gas chromatography/electron capture negative ion low resolution mass spectrometry applying single pure and representative synthesised chlorodecanes as standards

    International Nuclear Information System (INIS)

    Beaume, Florence; Coelhan, Mehmet; Parlar, Harun

    2006-01-01

    A new chlorodecane (CD) standard was developed consisting of five single compounds with 5-9 Cl-atoms, with which it was possible to determine chlorodecane residues in fish matrices from different countries using short column gas chromatography/electron capture negative ion low resolution mass spectrometry (SCGC/ECNI-LRMS). The concentrations found were between 4.8 and 30.2 ng/g fat. Pentachlorodecanes could not be detected in all samples. For an evaluation of the new CD-standard, the fish matrices were also quantified by several other polychlorinated decane (CP10) standards with different chlorine grade: 50, 55, 63.5, 65, and 70%. The concentrations found differed unsurprisingly considerable among the applied standards. Considering only these CP10:50-70% standards that showed the highest similarity in peak patterns with the fish samples, the differences in observed chlorodecane concentrations between these standards and the new CD-standard were low, varying only 1-16%. The CP10:50-70% standards were further quantified with the new CD-standard (chlorine content, 58.2%) with neglectable observed differences to the CP10:60, 63.5, and 65% standards. Highest differences were observed to the CP10:50, 55, and 70% standards. By this work, the quantification of eco-toxicologically relevant C10-chloroparaffins using the new CD-standard has led to reproducible and reliable results, which indicates further that these compounds are still a concerning class of substances in environmental fish samples

  20. Novel insertion mutation of ABCB1 gene in an ivermectin-sensitive Border Collie.

    Science.gov (United States)

    Han, Jae-Ik; Son, Hyoung-Won; Park, Seung-Cheol; Na, Ki-Jeong

    2010-12-01

    P-glycoprotein (P-gp) is encoded by the ABCB1 gene and acts as an efflux pump for xenobiotics. In the Border Collie, a nonsense mutation caused by a 4-base pair deletion in the ABCB1 gene is associated with a premature stop to P-gp synthesis. In this study, we examined the full-length coding sequence of the ABCB1 gene in an ivermectin-sensitive Border Collie that lacked the aforementioned deletion mutation. The sequence was compared to the corresponding sequences of a wild-type Beagle and seven ivermectin-tolerant family members of the Border Collie. When compared to the wild-type Beagle sequence, that of the ivermectin-sensitive Border Collie was found to have one insertion mutation and eight single nucleotide polymorphisms (SNPs) in the coding sequence of the ABCB1 gene. While the eight SNPs were also found in the family members' sequences, the insertion mutation was found only in the ivermectin-sensitive dog. These results suggest the possibility that the SNPs are species-specific features of the ABCB1 gene in Border Collies, and that the insertion mutation may be related to ivermectin intolerance.

  1. Antecedents of Cross-Border Acquisition Performance

    DEFF Research Database (Denmark)

    Wang, Daojuan; Moini, Hamid; Kuada, John Ernest

    2017-01-01

    This study investigates the impacts of main implementation activities on the success of cross-border acquisitions (CBAs), using survey data from a sample of 103 CBAs conducted by the companies in Nordic countries. The results of OLS regression analysis indicate that due diligence, integration...

  2. Implementation Issues of Cross-border Acquisitions

    DEFF Research Database (Denmark)

    Wang, Daojuan; Moini, Hamid; Kuada, John

    This study investigates the impacts of main implementation activities on the success of cross-border acquisitions (CBAs) using the survey data from a sample of 103 CBAs conducted by the companies in Scandinavia. The results of regression analysis indicate that due diligence, integration extent...

  3. Border Lakes land-cover classification

    Science.gov (United States)

    Marvin Bauer; Brian Loeffelholz; Doug. Shinneman

    2009-01-01

    This document contains metadata and description of land-cover classification of approximately 5.1 million acres of land bordering Minnesota, U.S.A. and Ontario, Canada. The classification focused on the separation and identification of specific forest-cover types. Some separation of the nonforest classes also was performed. The classification was derived from multi-...

  4. Stress Resilience among Border Mexican American Women

    Science.gov (United States)

    Guinn, Bobby; Vincent, Vern; Dugas, Donna

    2009-01-01

    The purpose of this study was to identify factors distinguishing Mexican American women living near the U.S.-Mexican border who are resilient to the experience of stress from those who are not. The study sample consisted of 418 participants ranging in age from 20 to 61 years. Data were gathered through a self-report survey instrument composed of…

  5. Border Disease Virus among Chamois, Spain

    Science.gov (United States)

    Rosell, Rosa; Cabezón, Oscar; Mentaberre, Gregorio; Casas, Encarna; Velarde, Roser; Lavín, Santiago

    2009-01-01

    Approximately 3,000 Pyrenean chamois (Rupicapra pyrenaica pyrenaica) died in northeastern Spain during 2005–2007. Border disease virus infection was identified by reverse transcription–PCR and sequencing analysis. These results implicate this virus as the primary cause of death, similar to findings in the previous epizootic in 2001. PMID:19239761

  6. International taxation and cross-border banking

    NARCIS (Netherlands)

    Huizinga, H.P.; Voget, J.; Wagner, W.B.

    This paper examines empirically how international taxation affects the volume and pricing of cross-border banking activities for a sample of banks in 38 countries over the 1998�2008 period. International double taxation of foreign-source bank income is found to reduce banking-sector FDI.

  7. Cross-border Mergers and Acquisitions

    DEFF Research Database (Denmark)

    Wang, Daojuan

    This paper focuses on three topics in cross-border mergers and acquisitions (CBM&As) field: motivations for CBM&As, valuation techniques and CBM&A performance (assessment and the determinants). By taking an overview of what have been found so far in academic field and investigating...

  8. International Taxation and Cross-Border Banking

    NARCIS (Netherlands)

    Huizinga, H.P.; Voget, J.; Wagner, W.B.

    2011-01-01

    This paper examines empirically how international taxation affects the volume and pricing of cross-border banking activities for a sample of banks in 38 countries over the 1998-2008 - period. Home country corporate income taxation of foreign-source bank income is found to reduce banking-sector FDI.

  9. Cross-border flow of health information

    DEFF Research Database (Denmark)

    Di Iorio, Concetta Tania; Carinci, Fabrizio; Brillante, Massimo

    2013-01-01

    The EUBIROD project aims to perform a cross-border flow of diabetes information across 19 European countries using the BIRO information system, which embeds privacy principles and data protection mechanisms in its architecture (privacy by design). A specific task of EUBIROD was to investigate...

  10. Border Protection and National Security of Mongolia

    Science.gov (United States)

    2006-09-01

    simple acts, such as a cartographer labeling an island “Turkish” instead of “ Greek ,” have triggered the mobilization of armed forces on both sides as...been replaced with marble columns that are guaranteed to last for a century. Parts of the state borders in some directions have been negotiated and

  11. Crossing Pedagogical Borders in the Yucatan Peninsula

    Science.gov (United States)

    Willhauck, Susan

    2009-01-01

    A challenging intercultural teaching experience provided an opportunity for engaging embodied pedagogies that facilitated border crossings of language, age, gender, and experience. Influenced by the work of Augusto Boal, the author describes how improvisation, role-play, music, and drawing led seminary students in Mexico into sacred time and space…

  12. THE LESSONS OF THE BORDER WAR

    African Journals Online (AJOL)

    Willem Scholtz

    At the time of writing, the Border War has been over for 24 years. Some of .... artillery together with other support troops were learnt.5 ..... Beforehand they were as excited as naïve children before a picnic; ..... and a tank squadron (which was later augmented with a second squadron). ..... They are distanced so far from reality.

  13. Sensory neuropathy in two Border collie puppies.

    Science.gov (United States)

    Vermeersch, K; Van Ham, L; Braund, K G; Bhatti, S; Tshamala, M; Chiers, K; Schrauwen, E

    2005-06-01

    A peripheral sensory neuropathy was diagnosed in two Border collie puppies. Neurological, electrophysiological and histopathological examinations suggested a purely sensory neuropathy with mainly distal involvement. Urinary incontinence was observed in one of the puppies and histological examination of the vagus nerve revealed degenerative changes. An inherited disorder was suspected.

  14. Legal aspects of cross-border teleradiology

    International Nuclear Information System (INIS)

    Pattynama, Peter M.T.

    2010-01-01

    The growth of cross-border teleradiology has created legal challenges that are insufficiently addressed by nation health laws. New legislation is currently under development at the European level. This article will look at the details of the existing and proposed legislation and the still unsettled issues and will discuss the implications for international teleradiology.

  15. Border Security: The Role of the U.S. Border Patrol

    National Research Council Canada - National Science Library

    Nunez-Neto, Blas

    2005-01-01

    .... Today, the USBP's primary mission is to detect and prevent the entry of terrorists, weapons of mass destruction, and illegal aliens into the country, and to interdict drug smugglers and other criminals along the border...

  16. Border Security: Immigration Issues in the 108th Congress

    National Research Council Canada - National Science Library

    Seghetti, Lisa M

    2004-01-01

    .... Prior to the terrorist attacks, the priorities for border security policy were beginning to shift from immigration-related issues to issues related to facilitating legitimate cross-border commerce...

  17. Border Security -- One Step Toward Resolving the Conflict in Iraq

    National Research Council Canada - National Science Library

    Bennett, Mark S

    2005-01-01

    .... It will do this by proving that border security is a key component to suppressing the Iraqi insurgency and that border security operations have been hindered by a lack of interagency coordination...

  18. Crossing borders: The Case of ethnic Dagestani in Georgia

    OpenAIRE

    Meurmishvili, Giorgi

    2014-01-01

    According to William Zartman Borders run across land but through people. On maps they appear as fine one-dimensional lines, whereas on the ground they have many dimensions. Borders are boundaries in depth, space around a line, place where state meets society" (Zartman 2010:16). It is impossible to understand borders, without peripheral relations between the states and societies they contain. Itself borders are zones in which people create special relationship with other people. ...

  19. International Border Management Systems (IBMS) Program : visions and strategies.

    Energy Technology Data Exchange (ETDEWEB)

    McDaniel, Michael; Mohagheghi, Amir Hossein

    2011-02-01

    Sandia National Laboratories (SNL), International Border Management Systems (IBMS) Program is working to establish a long-term border security strategy with United States Central Command (CENTCOM). Efforts are being made to synthesize border security capabilities and technologies maintained at the Laboratories, and coordinate with subject matter expertise from both the New Mexico and California offices. The vision for SNL is to provide science and technology support for international projects and engagements on border security.

  20. Hmong Across Borders or Borders Across Hmong? Social and Political Influences Upon Hmong People

    Directory of Open Access Journals (Sweden)

    Prasit Leepreecha

    2014-12-01

    Full Text Available The Hmong are a transnational ethnic people, because of their dispersal from China into Southeast Asia in the early 19th century and from Southeast Asia to Western countries from 1975 onward. However, even within the context of Southeast Asia and southern China, the Hmong are a transnational ethnic group, due to state boundaries and the enforcement of international laws.Scholars speak as though the Hmong population has crossed political and legal borders by their movement across state boundaries and international borders. However, I argue that it is the political, social, and legal borders that have cut across the Hmong people and subjected them to be citizens of different modern nation-states. Even in the present time, these borders still, and continuously, play important roles that cross and divide the Hmong people into distinctive subgroups and fragments. In this article, I will start by describing the generally understood situation of Hmong being across national borders, and then will explain my argument that borders are across the Hmong.

  1. 8 CFR 1212.6 - Border crossing identification cards.

    Science.gov (United States)

    2010-01-01

    ... combined B-1/B-2 visitor visa and non-biometric border crossing identification card or (a similar stamp in... non-biometric border crossing identification card (or similar stamp in a passport), issued by the DOS... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Border crossing identification cards. 1212...

  2. 76 FR 65207 - U.S. Customs and Border Protection

    Science.gov (United States)

    2011-10-20

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Notice of Cancellation of Customs Broker Licenses AGENCY: U.S. Customs and Border Protection, U.S. Department of Homeland Security.... 1641) and the U.S. Customs and Border Protection regulations (19 CFR 111.51), the following Customs...

  3. 76 FR 50883 - U.S. Customs and Border Protection

    Science.gov (United States)

    2011-08-17

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection DEPARTMENT OF THE TREASURY 19... of Liquidation AGENCY: Customs and Border Protection, Department of Homeland Security; Department of... Regulations (``CFR'') pertaining to the method by which U.S. Customs and Border Protection (``CBP'') issues...

  4. 78 FR 35044 - U.S. Customs and Border Protection

    Science.gov (United States)

    2013-06-11

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Visa Waiver Program Carrier Agreement (CBP Form I-775) AGENCY: U.S. Customs and Border Protection... information collection: 1651-0110. SUMMARY: U.S. Customs and Border Protection (CBP) of the Department of...

  5. 77 FR 59206 - U.S. Customs and Border Protection

    Science.gov (United States)

    2012-09-26

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Foreign Assembler's Declaration AGENCY: U.S. Customs and Border Protection (CBP), Department of... written comments to U.S. Customs and Border Protection, Attn: Tracey Denning, Regulations and Rulings...

  6. Picking and Choosing the ‘Sovereign’Border

    DEFF Research Database (Denmark)

    Parker, Noel; Adler-Nissen, Rebecca

    2012-01-01

    We argue that the continued persistence of borders is an effect of their constitutive role for the many dimensions of a social particular. States cannot choose to have a border; but they can and do make choices amongst the materials available on the various planes of inscription for bordering. Fo...

  7. IDentity, crude data and narrative at the border

    DEFF Research Database (Denmark)

    Møhl, Perle

    Based on ethnographic fieldwork among border control agents at a Schengen border point, the paper explores the linkages and dissociations between human and computer intelligence work in the daily operation of border control where voyagers are profiled, their IDs verified and their intentions scru...

  8. Gender, Cross-border Migrant Workers and Citizenship : Case Study ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... of the Burmese-Thai border; final technical report. Documents. Border industrialization and labour mobility : a case of Burmese migrant workers in border area factories. Rapports. Round Table Discussion on Past and Current Research on Migrant Workers in Thailand, Miracle Grand Convention Hotel, 17 January 2007 ...

  9. U.S. Border Patrol Fiscal Year Statistics Southwest border sector deaths - FY 1998 through FY 2013

    Data.gov (United States)

    Department of Homeland Security — Southwest Border Sectors include: Del Rio, El Centro, El Paso, Laredo, Rio Grande Valley, San Diego, Tucson, Yuma Southwest Border Deaths By Fiscal Year (Oct. 1st...

  10. Border patrol: insights into the unique role of perlecan/heparan sulfate proteoglycan 2 at cell and tissue borders.

    Science.gov (United States)

    Farach-Carson, Mary C; Warren, Curtis R; Harrington, Daniel A; Carson, Daniel D

    2014-02-01

    The extracellular matrix proteoglycan (ECM) perlecan, also known as heparan sulfate proteoglycan 2 or HSPG2, is one of the largest (>200 nm) and oldest (>550 M years) extracellular matrix molecules. In vertebrates, perlecan's five-domain structure contains numerous independently folding modules with sequence similarities to other ECM proteins, all connected like cars into one long, diverse complex train following a unique N-terminal domain I decorated with three long glycosaminoglycan chains, and an additional glycosaminoglycan attachment site in the C-terminal domain V. In lower invertebrates, perlecan is not typically a proteoglycan, possessing the majority of the core protein modules, but lacking domain I where the attachment sites for glycosaminoglycan chains are located. This suggests that uniting the heparan sulfate binding growth factor functions of domain I and the core protein functions of the rest of the molecule in domains II-V occurred later in evolution for a new functional purpose. In this review, we surveyed several decades of pertinent literature to ask a fundamental question: Why did nature design this protein uniquely as an extraordinarily long multifunctional proteoglycan with a single promoter regulating expression, rather than separating these functions into individual proteins that could be independently regulated? We arrived at the conclusion that the concentration of perlecan at functional borders separating tissues and tissue layers is an ancient key function of the core protein. The addition of the heparan sulfate chains in domain I likely occurred as an additional means of binding the core protein to other ECM proteins in territorial matrices and basement membranes, and as a means to reserve growth factors in an on-site depot to assist with rapid repair of those borders when compromised, such as would occur during wounding. We propose a function for perlecan that extends its role from that of an extracellular scaffold, as we previously

  11. [Development of residual voltage testing equipment].

    Science.gov (United States)

    Zeng, Xiaohui; Wu, Mingjun; Cao, Li; He, Jinyi; Deng, Zhensheng

    2014-07-01

    For the existing measurement methods of residual voltage which can't turn the power off at peak voltage exactly and simultaneously display waveforms, a new residual voltage detection method is put forward in this paper. First, the zero point of the power supply is detected with zero cross detection circuit and is inputted to a single-chip microcomputer in the form of pulse signal. Secend, when the zero point delays to the peak voltage, the single-chip microcomputer sends control signal to power off the relay. At last, the waveform of the residual voltage is displayed on a principal computer or oscilloscope. The experimental results show that the device designed in this paper can turn the power off at peak voltage and is able to accurately display the voltage waveform immediately after power off and the standard deviation of the residual voltage is less than 0.2 V at exactly one second and later.

  12. The Nature and Functions of European Political Borders

    Directory of Open Access Journals (Sweden)

    Jernej Zupančič

    2008-07-01

    Full Text Available The political border limits a state’s territory and symbolizes the extent of a state’s power and ownership. Borders give integrity to the inner state territory which they enclose (the role of establishing national integrity and at the same time form an outer boundary segregating the state territory from the surrounding politicial entities (the segregation role. European borders are old and reflect the political history of an old continent. The last major border changes happened after World War II. Over the centuries borders were merely lines separating one territory from another. Such borders were understood as »frontiers«. Forming an effective barrier against enemies was the overriding function of borders. Many borders were fortified and further enhanced by means of various defensive systems. In the second half of the 20th century the character of political borders changed. They became a contact area between countries, nations and cultures. Contemporary European borders reflect the colourful history of an old continent. They are predominantely functional markers: they represent the political and juridical delimitation of territories, they mark economic barriers and show their defensive nature and reveal the extent of cultural contact. As a result of European integration processes, the nature of political borders has changed: instead of division, their integration role is brought to the fore. A united Europe is nevertheless still not a borderless Europe! The borders within the »Schengen-area« have retained their political and administrative functions, it is just that the customs and security checks at the borders have been removed. During the period of European integration, borderlines were stabilized in accordance with the 1974 Helsinki Agreement. But despite this we can still observe ongoing changes to state borders, particularly in areas of conflict such as the Balkan peninsula. It seems after all that the process of demarcation

  13. The resurgence of cultural borders in international finance during the financial crisis: Evidence from Eurozone cross-border depositing

    NARCIS (Netherlands)

    Kleimeier, S.; Sander, H.; Heuchemer, S.

    2014-01-01

    In this paper, we demonstrate that cultural borders in international finance resurge during financial crises. To investigate the role of cultural borders during both tranquil and crisis periods, we employ a unique data set that focuses on Eurozone cross-border depositing in a gravity-model

  14. Opportunities for Cross-Border Entrepreneurship Development in a Cluster Model Exemplified by the Polish–Czech Border Region

    Directory of Open Access Journals (Sweden)

    Joanna Kurowska-Pysz

    2016-03-01

    Full Text Available The subject of the paper is the analysis and evaluation of cross-border entrepreneurship development opportunities on the basis of cross-border cooperation, which has gradually evolved from consisting of bilateral partnerships to a networking model or even a cluster. The study conducted at the Polish–Czech border area indicates that, in terms of the development of cross-border cooperation, the economic sphere is lagging far behind social activities such as culture, education and tourism. At the same time, Polish and Czech enterprises are not sufficiently mobilized to develop cross-border entrepreneurship, although a number of support instruments in this regard have been proposed. Sustainable development of the border should take into account both social and economic aspects. An important research problem therefore becomes determining the possibility of boosting the development of cross-border entrepreneurship on the basis of the existing forms of cross-border cooperation, including cooperation in the social sphere. The aim of this paper is to define the conditions and opportunities for the development of cluster cooperation in the area of cross-border entrepreneurship. The author has attempted to resolve whether the intensity of cross-border cooperation can be a factor which mobilizes companies to develop their cross-border entrepreneurship and whether cross-border entrepreneurship can be further developed within the cluster model.

  15. Cross-border cooperation potential in fostering redevelopment of degraded border areas - a case study approach.

    Science.gov (United States)

    Alexandre Castanho, Rui; Ramírez, Beatriz; Loures, Luis; Fernández-Pozo, Luis; Cabezas, José

    2017-04-01

    Border interactions have reached unprecedented levels in recent decades, not only due to their potential for territorial integration but also considering their role in supranational processes, such as landscape reclamation, infrastructure development and land use planning on European territory. In this scenario, successful examples related to the redevelopment of degraded areas have been showing positive impacts at several levels, such as the social, economic, environmental and aesthetic ones which have ultimately related this process, positively, to sustainability issues. However, concerning to border areas, and due to their inherent legislative and bureaucratic conflicts, the intervention in these areas is more complex. Still, and taking into account previously developed projects and strategies of cross-border cooperation (CBC) in European territory it is possible to identified that the definition of common master plans and common objectives are critical issues to achieve the desired territorial success. Additionally, recent studies have put forward some noteworthy ideas highlighting that it is possible to establish a positive correlation between CBC processes and an increasing redevelopment of degraded border areas, with special focus on the reclamation of derelict landscapes fostering soil reuse and redevelopment. The present research, throughout case study analysis at the Mediterranean level - considering case studies from Portugal, Spain, Monaco and Italy - which presents specific data on border landscape redevelopment, enables us to conclude that CBC processes have a positive influence on the potential redevelopment of degraded border areas, considering not only urban but also rural land. Furthermore, this paper presents data obtained through a public participation process which highlights that these areas present a greater potential for landscape reclamation, fostering resource sustainability and sustainable growth. Keywords: Spatial planning; Land

  16. DEVELOPMENT OF CROSS-BORDER AREAS. STUDY CASES REVIEW

    Directory of Open Access Journals (Sweden)

    Marcela\tȘLUSARCIUC

    2015-06-01

    Full Text Available The paper aims to review study cases found in the scientific literature concerning the development of cross- border areas in European Union and its neighbourhood. The introductory part of the paper is drawing few considerations about the cross-border areas. Further we identified in the specific literature relevant study cases that provide lessons learned, tools and models that can contribute to the development of the cross-border areas. The last part of the paper is focusing on an inquiry about how this lessons, learned, tools and models may be adapted in case of cross-border areas along the Romanian border with the EU Eastern Neighbourhood.

  17. Measuring cross-border regional integration with composite indicators

    DEFF Research Database (Denmark)

    Makkonen, Teemu

    2016-01-01

    Earlier quantitative studies on cross-border regional integration processes have commonly neglected science, technology and innovation (STI) indicators: even the most notable example of a composite indicator approach to measuring cross-border regional integration, i.e. the Oresund index, lacks...... a sub-category for STI. Consequently, by ignoring cross-border innovation and knowledge flows, the Oresund integration index fails to take into account one of the most important drivers of economic growth in cross-border regions. Therefore, a new composite STI indicator (sub-category) was introduced......-border regions....

  18. Astronomers Without Borders: A Global Astronomy Community

    Science.gov (United States)

    Simmons, M.

    2011-10-01

    Astronomers Without Borders (AWB) brings together astronomy enthusiasts of all types - amateur astronomers, educators, professionals and "armchair" astronomers for a variety of online and physicalworld programs. The AWB web site provides social networking and a base for online programs that engage people worldwide in astronomy activities that transcend geopolitical and cultural borders. There is universal interest in astronomy, which has been present in all cultures throughout recorded history. Astronomy is also among the most accessible of sciences with the natural laboratory of the sky being available to people worldwide. There are few other interests for which people widely separated geographically can engage in activities involving the same objects. AWB builds on those advantages to bring people together. AWB also provides a platform where projects can reach a global audience. AWB also provides unique opportunities for multidisciplinary collaboration in EPO programs. Several programs including The World at Night, Global Astronomy Month and others will be described along with lessons learned.

  19. Centronuclear myopathy in a Border collie dog.

    Science.gov (United States)

    Eminaga, S; Cherubini, G B; Shelton, G D

    2012-10-01

    A two-year old, male entire Border collie was presented with a one-year history of exercise-induced collapsing on the pelvic limbs. Physical examination revealed generalised muscle atrophy. Neurological examination supported a generalised neuromuscular disorder. Electromyography revealed spontaneous electrical activity in almost all muscles. Unfixed and formaldehyde-fixed biopsy samples were collected from the triceps brachii, longissimus and vastus lateralis muscles. Histopathological, histochemical and ultrastructural examinations of biopsy specimens were consistent with either centronuclear or myotubular myopathy. The dog clinically improved with supportive treatment with L-carnitine, co-enzyme Q10 and vitamin B compound. To the authors' knowledge, this is the first report of centronuclear/myotubular myopathy in a Border collie. © 2012 British Small Animal Veterinary Association.

  20. Borders and Borderlands in the Americas

    Science.gov (United States)

    2012-08-01

    both licit and illicit networks. Traditional territorial security concerns declined in the Americas following the end of the Cold War, and NAFTA in...deepen economic ties and liberalize regimes, privileging development over security.12 Similarly, trade, fostered through NAFTA , has shaped and affected...FOR FURTHER RESEARCH States determine what a “problem” at the border is through their constitutions , legal regimes, and policies. This means that

  1. International Taxation and Cross-Border Banking

    OpenAIRE

    Huizinga, H.P.; Voget, J.; Wagner, W.B.

    2011-01-01

    This paper examines empirically how international taxation affects the volume and pricing of cross-border banking activities for a sample of banks in 38 countries over the 1998-2008 - period. Home country corporate income taxation of foreign-source bank income is found to reduce banking-sector FDI. Furthermore, such taxation is almost fully passed on into higher interest margins charged abroad. These results imply that international double taxation distorts the activities of international ban...

  2. Cross border M and A environment

    International Nuclear Information System (INIS)

    Hill, M.B.

    1998-01-01

    An overview of the Canada-U.S. cross-border merger and acquisition environment and exchangeable share structure within the petroleum industry is provided. Recent U.S. acquisitions in Canada, Canadian investment conditions, indexed price analysis from January 1, 1997 to October 16, 1998, and a variety of other share price/cash flow statistics relevant to mergers and acquisitions are examined. tabs., figs

  3. Vocal and Tangible Interaction Crossing Borders

    OpenAIRE

    Andersson, Anders-Petter; Cappelen, Birgitta

    2013-01-01

    Our voice and body are important parts of our self-expression and self-experience for all of us. They are also essential for our way to communicate and build relations cross borders such as abilities, ages, locations and backgrounds. Voice, body and tangibility gradually become more important for ICT, due to increased development of tangible interaction and mobile communication. The voice and tangible interaction therefore also become more important for the Universal Design field. In this pap...

  4. Culture as a Moving Symbolic Border.

    Science.gov (United States)

    Simão, Lívia Mathias

    2016-03-01

    The aim of this paper is to propose the notion of culture as a symbolic moving border. Departing from both, Boesch's (1991) concept of culture as a symbolic field of action, and Herbst's (1995) co-genetic logic, I will discuss the dynamics of self-other relationships in terms of their potentiality as sources of movement in culture. A brief analysis of an empirical material is given in illustrative character of the ideas here exposed.

  5. Of States and Borders on the Internet

    DEFF Research Database (Denmark)

    Shklovski, Irina; Struthers, David

    2010-01-01

    their activity on the Internet as happening within or outside the space of the state to which they felt allegiance and belonging. National borders are demarcated on the Internet through naming via ccTLDs and can result in individual expressions of various types of nationalism online. We find that cc......TLDs are not just symbolic markers but have real meaning and their importance increases in locations where notions of statehood are in flux....

  6. Type 2 diabetes mortality at Mexican borders

    OpenAIRE

    Manzanares Rivera, José Luis

    2017-01-01

    Abstract:Objective: To analyze type II diabetes mortality rates geographic distribution and evolution in time across both Mexican border regions during the period 1998-2013.Methods: The work is based on exploratory and inferential data analysis conducted using death reports from the national health information system. The analysis considers social determinants of health as a theoretical paradigm and includes microdata on consumption patterns at household level for the US-Mexico and Mexico- Gu...

  7. Ceroid-lipofuscinosis in border collie dogs.

    Science.gov (United States)

    Taylor, R M; Farrow, B R

    1988-01-01

    Five Border Collie dogs with ceroid-lipofuscinosis developed progressive neurological disease between 18 and 22 months of age. These dogs had behavioural abnormalities, gait and visual deficits and became progressively demented. All dogs examined had common ancestors. Light microscopic examination of tissues demonstrated extensive accumulation of granular, sudan black-staining autofluorescent material in the cytoplasm of neurones, retinal ganglion cells and some visceral cells. At ultrastructural examination inclusions of variable morphology were observed.

  8. The structure of borders in a small world.

    Science.gov (United States)

    Thiemann, Christian; Theis, Fabian; Grady, Daniel; Brune, Rafael; Brockmann, Dirk

    2010-11-18

    Territorial subdivisions and geographic borders are essential for understanding phenomena in sociology, political science, history, and economics. They influence the interregional flow of information and cross-border trade and affect the diffusion of innovation and technology. However, it is unclear if existing administrative subdivisions that typically evolved decades ago still reflect the most plausible organizational structure of today. The complexity of modern human communication, the ease of long-distance movement, and increased interaction across political borders complicate the operational definition and assessment of geographic borders that optimally reflect the multi-scale nature of today's human connectivity patterns. What border structures emerge directly from the interplay of scales in human interactions is an open question. Based on a massive proxy dataset, we analyze a multi-scale human mobility network and compute effective geographic borders inherent to human mobility patterns in the United States. We propose two computational techniques for extracting these borders and for quantifying their strength. We find that effective borders only partially overlap with existing administrative borders, and show that some of the strongest mobility borders exist in unexpected regions. We show that the observed structures cannot be generated by gravity models for human traffic. Finally, we introduce the concept of link significance that clarifies the observed structure of effective borders. Our approach represents a novel type of quantitative, comparative analysis framework for spatially embedded multi-scale interaction networks in general and may yield important insight into a multitude of spatiotemporal phenomena generated by human activity.

  9. [Antituberculosis-drug resistance in the border of Brazil with Paraguay and Bolivia].

    Science.gov (United States)

    Marques, Marli; Cunha, Eunice Atsuko Totumi; Evangelista, Maria do Socorro Nantua; Basta, Paulo Cesar; Marques, Ana Maria Campos; Croda, Julio; de Andrade, Sonia Maria Oliveira

    2017-04-20

    To estimate the rate of drug resistance among pulmonary tuberculosis (PTB) cases in the state of Mato Grosso do Sul, Brazil, and specifically in the border areas with Paraguay and Bolivia, as well as to identify associated risk factors. The present cross-sectional, epidemiological study focused on PTB cases recorded between January 2007 and December 2010 in the State Reportable Disease Information System with results of susceptibility tests to rifampicin, isoniazid, ethambutol, and streptomycin. Dependent variables were development of resistance to a single drug or any combination of drugs. Independent variables were being a new or treated case, living in border areas, presence/absence of diabetes, and history of alcoholism. There were 789 TBP cases with susceptibility testing. The following characteristics were associated with resistance: treated case (P = 0.0001), border region (P = 0.0142), alcoholism (P = 0.0451), and diabetes (P = 0.0708). The rates of combined, primary, and acquired resistance for the state were 16.3%, 10.6%, and 39.0%, vs. 22.3%, 19.2%, and 37.5% for the border region. The rates of combined, primary, and acquired multidrug resistance for the state were 1.8%, 0.6%, and 6.3%, vs. 3.1%, 1.2%, and 12.5% for the border region. In the border region, the state should investigate drug resistance in all patients with respiratory symptoms, determine the pattern of resistance in confirmed cases, adopt directly observed treatment for cases of PTB, and develop health actions together with neighboring countries. Across the state, the levels of acquired resistance should be monitored, with investigation of resistance in all treated cases and implementation of directly observed treatment especially among patients with diabetes or alcoholism.

  10. EU Outer Borders and Radiation - An Urgent Need for Standardization, New Detector Technologies and Education Harmonization

    International Nuclear Information System (INIS)

    Prlic, Ivica; Suric Mihic, Marija; Kosmina, Domagoj; Shaw, Peter; Hajdinjak, Mladen; Cerovac, Zdravko; Bozina, Zeljko

    2014-01-01

    It appears that new IAEA transport regulations are s tarting to bite - as now there is a definite requirement for assessments of all relevant radio-nuclides in n on-equilibrium mixes': It is heard that several shipments that were either delayed significantly or rejected all together in ports in the EU. Things like synthetic rutile, zirconia, copper concentrates, and so on... Devise a NORM Passport for NORM shipments : including a text description of the material and photographs, radionuclide content plus some radiological data (dose rates, gamma spectrum and maybe also something on trigger levels for border monitoring alarms). Produce a guidance booklet for border control authorities. The two suggestions are connected, and Ii is suggested that they form a single project of how to equip the EU border contort facilities. Denial of shipment due to border alarms is an issue that affects industry- that is why it is hoped that they would be interested in being involved. Clearly it is needed to address world-wide transport (i.e. because that's where most of the NORM comes from). The whole EU outer border customs protocol is th be added to above mentioned monitoring of NORM. The new radiation technologies are used to fulfill the security issues (like stowaways, smuggling, ilicit trafficking etc..). All above mentioned forces us to standardize the customs protocols, to upgrade the education of involved workers and fo harmonize the issue throughout the EU. Croatia is a front point in the moment because of the very long and 'soft' outer EU border. (authors)

  11. Small Border Traffic and Cross-Border Tourism Between Poland and the Kaliningrad Oblast of the Russian Federation

    Directory of Open Access Journals (Sweden)

    Anisiewicz Renata

    2014-06-01

    Full Text Available Polish and Russian cross-border cooperation is governed by lawful agreements. The enlargement of the Schengen Area had a significant impact on Kaliningrad Oblast relations and cross-border cooperation with its neighbours. The introduction of visas between Poland and Russia hindered and restricted local border trade which had for years been the only measure mitigating social and economic problems of the cross-border regions. Nevertheless, border traffic between Poland and Kaliningrad grew steadily, to exceed four million in 2012.

  12. Residual gas analysis

    International Nuclear Information System (INIS)

    Berecz, I.

    1982-01-01

    Determination of the residual gas composition in vacuum systems by a special mass spectrometric method was presented. The quadrupole mass spectrometer (QMS) and its application in thin film technology was discussed. Results, partial pressure versus time curves as well as the line spectra of the residual gases in case of the vaporization of a Ti-Pd-Au alloy were demonstrated together with the possible construction schemes of QMS residual gas analysers. (Sz.J.)

  13. Border Malaria Associated with Multidrug Resistance on Thailand-Myanmar and Thailand-Cambodia Borders: Transmission Dynamic, Vulnerability, and Surveillance

    Science.gov (United States)

    Bhumiratana, Adisak; Intarapuk, Apiradee; Sorosjinda-Nunthawarasilp, Prapa; Maneekan, Pannamas; Koyadun, Surachart

    2013-01-01

    This systematic review elaborates the concepts and impacts of border malaria, particularly on the emergence and spread of Plasmodium falciparum and Plasmodium vivax multidrug resistance (MDR) malaria on Thailand-Myanmar and Thailand-Cambodia borders. Border malaria encompasses any complex epidemiological settings of forest-related and forest fringe-related malaria, both regularly occurring in certain transmission areas and manifesting a trend of increased incidence in transmission prone areas along these borders, as the result of interconnections of human settlements and movement activities, cross-border population migrations, ecological changes, vector population dynamics, and multidrug resistance. For regional and global perspectives, this review analyzes and synthesizes the rationales pertaining to transmission dynamics and the vulnerabilities of border malaria that constrain surveillance and control of the world's most MDR falciparum and vivax malaria on these chaotic borders. PMID:23865048

  14. Border Malaria Associated with Multidrug Resistance on Thailand-Myanmar and Thailand-Cambodia Borders: Transmission Dynamic, Vulnerability, and Surveillance

    Directory of Open Access Journals (Sweden)

    Adisak Bhumiratana

    2013-01-01

    Full Text Available This systematic review elaborates the concepts and impacts of border malaria, particularly on the emergence and spread of Plasmodium falciparum and Plasmodium vivax multidrug resistance (MDR malaria on Thailand-Myanmar and Thailand-Cambodia borders. Border malaria encompasses any complex epidemiological settings of forest-related and forest fringe-related malaria, both regularly occurring in certain transmission areas and manifesting a trend of increased incidence in transmission prone areas along these borders, as the result of interconnections of human settlements and movement activities, cross-border population migrations, ecological changes, vector population dynamics, and multidrug resistance. For regional and global perspectives, this review analyzes and synthesizes the rationales pertaining to transmission dynamics and the vulnerabilities of border malaria that constrain surveillance and control of the world’s most MDR falciparum and vivax malaria on these chaotic borders.

  15. Cross-border policy effects on alcohol outcomes: drinking without thinking on the u.s.-Mexico border?

    Science.gov (United States)

    Mills, Britain A; Caetano, Raul; Vaeth, Patrice

    2014-11-01

    Rates of alcohol-related outcomes are sensitive to policy differences in politically distinct, adjacent territories. Factors that shape these cross-border effects, particularly when the policy differences are longstanding, remain poorly understood. We compared the ability of 2 classes of variables with theoretical relevance to the U.S.-Mexico border context-bar attendance and alcohol-related social-cognitive variables-to explain elevated drinking on the U.S. side of the border relative to other areas of the United States. Data were collected from multistage cluster samples of adult Mexican Americans on and off the U.S.-Mexico border (current drinker N = 1,351). Structural equation models were used to test drinking context (frequency of bar attendance) and 6 different social-cognitive variables (including alcohol-related attitudes, norms, motives, and beliefs) as mediators of border effects on a composite drinking index. The border effect on drinking varied by age (with younger adults showing a stronger effect), consistent with previous findings and known risk factors in the region. Contrary to theoretical expectations, 6 different social-cognitive variables-despite relating strongly with drinking-were comparable in border and nonborder areas (within and across age) and played no role in elevated drinking on the border. Conversely, elevated drinking among border youth was mediated by bar attendance. This mediated moderation effect held after adjusting for potential sociodemographic and neighborhood-level confounders. Increased drinking among U.S.-Mexico border youth is explained by patterns of bar attendance, but not by more permissive alcohol-related social-cognitive variables in border areas: Border youth attend bars and drink more than their nonborder counterparts, despite having comparable alcohol-related beliefs, attitudes, norms, and motives for use. Alcohol's heightened availability and visibility on both sides of the border may create opportunities for

  16. Borders as membranes :metaphors and models for improved policy in border regions.

    Energy Technology Data Exchange (ETDEWEB)

    Malczynski, Leonard A.; Passell, Howard David; Forster, Craig B. (University of Utah, Salt Lake City, UT); Cockerill, Kristan (Cockerill Consulting, Boone, NC)

    2005-10-01

    Political borders are controversial and contested spaces. In an attempt to better understand movement along and through political borders, this project applied the metaphor of a membrane to look at how people, ideas, and things ''move'' through a border. More specifically, the research team employed this metaphor in a system dynamics framework to construct a computer model to assess legal and illegal migration on the US-Mexico border. Employing a metaphor can be helpful, as it was in this project, to gain different perspectives on a complex system. In addition to the metaphor, the multidisciplinary team utilized an array of methods to gather data including traditional literature searches, an experts workshop, a focus group, interviews, and culling expertise from the individuals on the research team. Results from the qualitative efforts revealed strong social as well as economic drivers that motivate individuals to cross the border legally. Based on the information gathered, the team concluded that legal migration dynamics were of a scope we did not want to consider hence, available demographic models sufficiently capture migration at the local level. Results from both the quantitative and qualitative data searches were used to modify a 1977 border model to demonstrate the dynamic nature of illegal migration. Model runs reveal that current US-policies based on neo-classic economic theory have proven ineffective in curbing illegal migration, and that proposed enforcement policies are also likely to be ineffective. We suggest, based on model results, that improvement in economic conditions within Mexico may have the biggest impact on illegal migration to the U.S. The modeling also supports the views expressed in the current literature suggesting that demographic and economic changes within Mexico are likely to slow illegal migration by 2060 with no special interventions made by either government.

  17. Smart border initiative: a Franco-German cross-border energy optimisation project

    International Nuclear Information System (INIS)

    2017-01-01

    Integrated and optimised local energy systems will play a key role in achieving the energy transition objectives set by France and Germany, in line with the Energy Union's goals, and contribute to ensuring a secure, affordable and climate-friendly energy supply in the EU. In order to capitalise on the French and German expertise and experiences in developing such systems and to continue strengthening the cross-border cooperation towards a fully integrated European energy market, both Governments have decided to launch a common initiative to identify and structure a cross-border energy optimisation project. Tilia and Dena have undertaken this mission to jointly develop the Smart Border Initiative (SBI). The SBI will, on the one hand, connect policies designed by France and Germany in order to support their cities and territories in their energy transition strategies and European market integration. It is currently a paradox that, though more balanced and resilient energy systems build up, bottom-up, at the local level, borders remain an obstacle to this local integration, in spite of the numerous complementarities observed in cross-border regions, and of their specific needs, in terms of smart mobility for example. The SBI project aims at enabling European neighbouring regions separated by a border to jointly build up optimised local energy systems, and jointly develop their local economies following an integrated, sustainable and low-carbon model. On the other hand, this showcase project will initiate a new stage in the EU electricity market integration, by completing high voltage interconnections with local, low voltage integration at DSO level, opening new optimisation possibilities in managing the electricity balance, and enabling DSOs to jointly overcome some of the current challenges, notably the increased share of renewable energy (RE) and ensuring Europe's security of supply

  18. Bordering Binarities and Cognitive Cartography: What on Earth Does Literature Have to do with Border Transactions?

    Directory of Open Access Journals (Sweden)

    Ruben Moi

    2009-03-01

    Full Text Available Although literature and poetry have numerous borders of their own,these are rarely assumed to have any significance for the world out-side the text itself. A number of reasons for this distinctive division certainly stem from the literary field itself. This paper intends to indicate the exclusivist stance of some theories of literature, and the inclucivist of others, before exploring the possibilities of bridging between borders in text and territory by reference to the life and literature of Oscar Wilde and a performative and imaginative analysis of Paul Muldoon's epigrammatic poem The Plot.

  19. Robust simultaneous detection of coronary borders in complex images

    International Nuclear Information System (INIS)

    Sonka, M.; Winniford, M.D.; Collins, S.M.

    1995-01-01

    Visual estimation of coronary obstruction severity from angiograms suffers from poor inter- and intraobserver reproducibility and is often inaccurate. In spite of the widely recognized limitations of visual analysis, automated methods have not found widespread clinical use, in part because they too frequently fail to accurately identify vessel borders. The authors have developed a robust method for simultaneous detection of left and right coronary borders that is suitable for analysis of complex images with poor contrast, nearby or overlapping structures, or branching vessels. The reliability of the simultaneous border detection method and that of their previously reported conventional border detection method were tested in 130 complex images, selected because conventional automated border detection might be expected to fail. Conventional analysis failed to yield acceptable borders in 65/130 or 50% of images. Simultaneous border detection was much more robust (p < .001) and failed in only 15/130 or 12% of complex images. Simultaneous border detection identified stenosis diameters that correlated significantly better with observer-derived stenosis diameters than did diameters obtained with conventional border detection (p < 0.001). Simultaneous detection of left and right coronary borders is highly robust and has substantial promise for enhancing the utility of quantitative coronary angiography in the clinical setting

  20. Cross-Border Patent Disputes: Unified Patent Court or International Commercial Arbitration?

    OpenAIRE

    Alba Betancourt, Ana

    2016-01-01

    Currently, the enforcement of a patent that is registered in several countries involves the risk of getting different and conflicting decisions from the national courts. In 2013, 25 European countries entered in an agreement that aims to homogenise the patent system by creating the European patent with unitary effect and a Unified Patent Court (UPC). This article focuses on the UPC, which aims to have a single court proceeding for cross-border patent conflicts. Does the UPC system represent a...

  1. Prevalence, heritability and genetic correlations of congenital sensorineural deafness and pigmentation phenotypes in the Border Collie.

    Science.gov (United States)

    De Risio, Luisa; Lewis, Tom; Freeman, Julia; de Stefani, Alberta; Matiasek, Lara; Blott, Sarah

    2011-06-01

    The objectives of this study were to estimate prevalence, heritability and genetic correlations of congenital sensorineural deafness (CSD) and pigmentation phenotypes in the Border Collie. Entire litters of Border Collies that presented to the Animal Health Trust (1994-2008) for assessment of hearing status by brain stem auditory evoked response (BAER) at 4-10 weeks of age were included. Heritability and genetic correlations were estimated using residual maximum likelihood (REML). Of 4143 puppies that met the inclusion criteria, 97.6% had normal hearing status, 2.0% were unilaterally deaf and 0.4% were bilaterally deaf. Heritability of deafness as a trichotomous trait (normal/unilaterally deaf/bilaterally deaf) was estimated at 0.42 using multivariate analysis. Genetic correlations of deafness with iris colour and merle coat colour were 0.58 and 0.26, respectively. These results indicate that there is a significant genetic effect on CSD in Border Collies and that some of the genes determining deafness also influence pigmentation phenotypes. Copyright © 2010 Elsevier Ltd. All rights reserved.

  2. Nuclear Security in Action at Malaysian Borders

    International Nuclear Information System (INIS)

    Dahlstrom Danielle

    2013-01-01

    ''For Malaysia, trade has to be a transparent'', explained Raja Adnan, the Director General of the Malaysian Atomic Energy Licensing Board (AELB). ''Goods are imported and exported, not just between two countries, but are in transit between several countries. Nuclear security measures help to guarantee open trade and makes sure that everyone is trading responsibly,'' emphasized Adnan. Officials from AELB prepare for a joint Indonesian-Malaysian exercise in effective border control by reviewing their national standard operating procedures (SOPs) on nuclear security, which were developed in close coordination with the IAEA

  3. Comparative balance of border regulations in four neighboring Caribbean countries

    Directory of Open Access Journals (Sweden)

    Silvia Cristina Mantilla Valbuena

    2016-07-01

    Full Text Available This article seeks to investigate whether there is a potential for border integration among four adjoining Caribbean countries: Colombia, Nicaragua, Panama and Costa Rica. The discussion is part of the “cross-border” concept and the integration of subnational entities in two or more nation states, with particular emphasis on the role played by the societies that inhabit border regions. A comparative analysis model is used to assess border regulations in each country’s various territorial levels based on relevant legal elements, autonomous processes and decentralization. The article concludes that the more modern each country’s border regulations and constitutional, political and administrative reforms are, the greater the likelihood of cross-border integration. Colombia and Nicaragua have the highest potential for integrating their borders, whereas Panama and Costa Rica have the lowest potential.

  4. Temporary reintroduction of border controls at French borders inside the Schengen Area

    CERN Multimedia

    2015-01-01

    The French authorities have informed CERN that, in view of the upcoming COP21 Paris Climate Conference, France will exceptionally reintroduce controls at its borders with Schengen states for one month from 13 November to 13 December 2015. All border posts and crossing points between France and Switzerland will be affected by this measure.   Members of the personnel are therefore reminded that, when crossing borders within the Schengen Area*, they must carry: either, in the case of citizens of European Economic Area (EEA) countries and Switzerland, an official identity document (identity card or passport); or, in the case of non-EEA and non-Swiss citizens, an identity document together with a Schengen visa if they are subject to this obligation, or an identity document together with a residence permit issued by a Schengen state** if they have one.   The French authorities will make every effort to limit the impact of this measure on cross-border traffic, and wish to thank the members of th...

  5. Over the border - the problems of uncontrolled radioactive materials crossing national borders

    Energy Technology Data Exchange (ETDEWEB)

    Duftschmid, K.E. E-mail: k.duftschmid@aon.at

    2002-03-01

    Cross-border movement of radioactive materials and contaminated items, in particular metallurgical scrap, has become a problem of increasing importance. Radioactive sources out of regulatory control, now often called 'orphan sources', have frequently caused serious, even deadly, radiation exposures and widespread contamination. The United States Nuclear Regulatory Commission reported over 2300 incidents of radioactive materials found in recycled metal scrap and more than 50 accidental smeltings of radioactive sources. A further potentially serious problem is illicit trafficking in nuclear and other radioactive materials. In 1995 the International Atomic Energy Agency (IAEA) started a programme to combat illicit trafficking in nuclear and other radioactive materials, which includes an international database on incidents of illicit trafficking, receiving reports from some 80 member states. For the period 1993-2000 the IAEA database includes 345 confirmed incidents. While from 1994-1996 the frequency declined significantly, this trend has been reversed since 1997, largely due to radioactive sources rather than nuclear material. This paper compares monitoring techniques for radioactive materials in scrap applied at steel plants and scrap yards with monitoring at borders, a completely different situation. It discusses the results of the 'Illicit Trafficking Radiation Detection Assessment Program', a large international pilot study, conducted in cooperation between the IAEA, the Austrian Government and the Austrian Research Centre Seibersdorf. The aim of this exercise was to derive realistic and internationally agreed requirements for border monitoring instrumentation. Finally the present extent of border monitoring installations is discussed. (author)

  6. Sustainable Planning of Cross-Border Cooperation: A Strategy for Alliances in Border Cities

    Directory of Open Access Journals (Sweden)

    Joanna Kurowska-Pysz

    2018-05-01

    Full Text Available In recent years, cooperation among nations has become a critical issue towards sustainable development of neighbor cities in border areas. In this regard, sustainable common planning approaches and policies are an increasing reality, particularly in European territories. Considering the significant amount of cross-border cooperation (CBC projects and strategies within Europe, it is crucial to promote research approaches that are able to identify the most positive approaches towards the establishment of alliances in border territories, serving as pivotal methodologies for achieving success. Contextually, the present study considered direct and indirect research methods and tools, literature reviews, data collection, computer-assisted telephone interviewing (CATI and computer-assisted web interview (CAWI, all applied over two European border cities: Cieszyn (Poland and Cesky Tesin (Czech Republic. These methods enabled the assembly of perspectives of local authorities, public and private institutions, non-governmental organizations, and entrepreneurs from the cities under study. Through the analysis of the collected data, five conditions have been identified for the success of strategic alliances in CBC projects: (i well defining the alliance goals; (ii ensuring participation in the alliance of various groups of stakeholders; (iii involvement of both partners with extensive experience in CBC; (iv ensuring the coherence of the key objective; and (v guaranteeing the alliance benefits both sides. These conditions might effectively contribute to achieve more successful outputs in CBC projects, highlighting the relevance of previously developed strategies on the definition of future approaches.

  7. Handling of Solid Residues

    International Nuclear Information System (INIS)

    Medina Bermudez, Clara Ines

    1999-01-01

    The topic of solid residues is specifically of great interest and concern for the authorities, institutions and community that identify in them a true threat against the human health and the atmosphere in the related with the aesthetic deterioration of the urban centers and of the natural landscape; in the proliferation of vectorial transmitters of illnesses and the effect on the biodiversity. Inside the wide spectrum of topics that they keep relationship with the environmental protection, the inadequate handling of solid residues and residues dangerous squatter an important line in the definition of political and practical environmentally sustainable. The industrial development and the population's growth have originated a continuous increase in the production of solid residues; of equal it forms, their composition day after day is more heterogeneous. The base for the good handling includes the appropriate intervention of the different stages of an integral administration of residues, which include the separation in the source, the gathering, the handling, the use, treatment, final disposition and the institutional organization of the administration. The topic of the dangerous residues generates more expectation. These residues understand from those of pathogen type that are generated in the establishments of health that of hospital attention, until those of combustible, inflammable type, explosive, radio-active, volatile, corrosive, reagent or toxic, associated to numerous industrial processes, common in our countries in development

  8. Beneficial Insect Borders Provide Northern Bobwhite Brood Habitat

    Science.gov (United States)

    Moorman, Christopher E.; Plush, Charles J.; Orr, David B.; Reberg-Horton, Chris

    2013-01-01

    Strips of fallow vegetation along cropland borders are an effective strategy for providing brood habitat for declining populations of upland game birds (Order: Galliformes), including northern bobwhite (Colinus virginianus), but fallow borders lack nectar-producing vegetation needed to sustain many beneficial insect populations (e.g., crop pest predators, parasitoids, and pollinator species). Planted borders that contain mixes of prairie flowers and grasses are designed to harbor more diverse arthropod communities, but the relative value of these borders as brood habitat is unknown. We used groups of six human-imprinted northern bobwhite chicks as a bioassay for comparing four different border treatments (planted native grass and prairie flowers, planted prairie flowers only, fallow vegetation, or mowed vegetation) as northern bobwhite brood habitat from June-August 2009 and 2010. All field border treatments were established around nine organic crop fields. Groups of chicks were led through borders for 30-min foraging trials and immediately euthanized, and eaten arthropods in crops and gizzards were measured to calculate a foraging rate for each border treatment. We estimated arthropod prey availability within each border treatment using a modified blower-vac to sample arthropods at the vegetation strata where chicks foraged. Foraging rate did not differ among border treatments in 2009 or 2010. Total arthropod prey densities calculated from blower-vac samples did not differ among border treatments in 2009 or 2010. Our results showed plant communities established to attract beneficial insects should maximize the biodiversity potential of field border establishment by providing habitat for beneficial insects and young upland game birds. PMID:24376759

  9. "Crossing Borders" ja valmimislootuses Eesti Muusika- ja Teatriakadeemia / Malle Maltis

    Index Scriptorium Estoniae

    Maltis, Malle, 1977-

    2010-01-01

    19. - 29. augustini EMTAs toimunud rahvusvahelisest suvekursusest "Crossing Borders in Interpretation of Classical Music and Jazz". Kooli välissuhete prorektor sellest projektist ja muusikaakadeemia juurdeehitusest

  10. Divided we fall... or rise? Tajikistan–Kyrgyzstan border dilemma

    Directory of Open Access Journals (Sweden)

    Anna Matveeva

    2017-02-01

    Full Text Available The Kyrgyzstan–Tajikistan border remains one of the last undefined frontiers in the Commonwealth of Independent States, where the governments are reluctant to act against the wishes of their border communities and force delimitation solutions that may cause social protests. Uncertainty of territorial arrangements persists; however, the era of commonality and interdependence may be at its end due to the establishment of a border as a means of spatial control. Border drawing reflects the divergent development trajectories of the new states, seeking to break out of an interdependence pattern. Borderlands’ interactions become more conflictual. Generation change and a loss of common language work to widen the inter-communal gap. Ethnicity and identity factors grew in significance as association with the nation-states increased, and a border expresses a symbol of nationhood in this paradigm. Crucially, a border justifies a security regime, reinforced by international assistance policies, to project power over the territory. Actions of security structures cause grievances but also signify a protective arm of the state, a role that the border communities appreciate, themselves acting as a collective border guard and projecting their fears of encroachment onto the borders. The expansion of the Eurasian Economic Union became a new factor that could have served to alleviate the pressure to divide territory and assets, but this could work only if two countries joined it at the same period. With this option unavailable, a territorial impasse has been reached.

  11. Cross-border entrepreneurship in a global world

    DEFF Research Database (Denmark)

    Emontspool, Julie; Servais, Per

    2017-01-01

    This paper shows that international entrepreneurship and immigrant entrepreneurship increasingly intersect in a global world. Both research streams address cross-border entrepreneurial activity in parallel to each other. International entrepreneurship focuses on outgoing entrepreneurial activity......, while immigrant entrepreneurship mainly considers incoming entrepreneurial activity. This paper critically discusses such a dichotomy, highlighting how differentiating immigrant entrepreneurs and international entrepreneurs perpetuates orientalist assumptions about cross-border business activity....... Focusing on a entrepreneurship as behaviour, the paper proposes an alternative perspective to cross-border entrepreneurship, discussing cross-border opportunity identification and exploitation between an entrepreneur’s country of residence and a foreign country. This perspective provides a number...

  12. Berlin: Emergency shelters and contemporary border struggles

    Directory of Open Access Journals (Sweden)

    Žiga Podgornik-Jakil

    2016-06-01

    Full Text Available Researching the developments of present political economy must necessarily include investigating the tools of contemporary border regime. These are used for surveillance and control of populations in order to create new divisions of labour and enable extraction of rent by using peoples’ bodies. The article focuses on emergency shelters in Berlin, that is, on their function and ways in which the asylum seekers accommodated there spontaneously struggle against them. The research was done as a militant and cooperative work of the network Lager Mobilisation Network in Berlin’s district Wedding, which builds connections with people housed in the sports halls in the mentioned district. The author underlines that exhausting the aslyum seekers psychically is one of the strategies for filtering the ‘unwanted’ from the ‘wanted’, that is the ones that are interesting for the labour market. At the same time, the restriction of movement and limited access to civil rights confine asylum seekers in emergency shelters run by private companies, which seek profits on their account. Far from claiming that non-profit companies have a ‘better’ shelter administration, since the boundaries between them and profit-oriented companies are often blurred, the author rather speaks of new forms of anticolonial struggles by the people living inside. He understands these struggles as the struggles against the contemporary border regime in Germany and the EU and as a potential for building an inclusive society.

  13. First Philosophy in the Border Zone

    Directory of Open Access Journals (Sweden)

    Viggo Rossvaer

    2016-09-01

    Full Text Available The article will be devoted to such problems as a idea of subsidiarity, a cosmopolitan right and a visitor figure in context and interpretation of ancient and modern philosophy. The article deals with the concept of subsidiarity which is taken as a point of departure for the discipline of borderology, an academic study with Kantian roots. Borderology, according to the principle of subsidiarity, can present as a new field of investigation which invites philosophers and social scientists to replace a “top down” with a “bottom up” procedure. The figure of the visitor is close linked with the experience of subsidiarity which means the freedom and initiative below the level of State. In Immanuel Kant’s strategy for perpetual peace, the figure of the visitor launches a critique of a tendency to self-aggrandizement, characteristic of the modern State and thereby a defense of the political independence of local border regions. The visitor also invites us to see, think and work to liberate our own subjectivity from false voices of sovereignty. Kant articulates the offer of the visitor by bringing in the term Verkehr. Using Kant scholar Otfried Höffe,s methodology we show how idea of subsidiarity is overlooked in international political theory, explain some constitutive principles of borderology, from which is more important is the methodological principle of an intercultural discourse and presents borderology as an anti-Huntingtonian model for border studies.

  14. Spectrum of critical illness in undocumented border crossers. The Arizona-Mexico border experience.

    Science.gov (United States)

    Wong, Candy; Hsu, Wendy; Carr, Gordon E

    2015-03-01

    Approximately 150-250 migrants die each year while attempting to cross the border from Mexico to the Southwest United States. Many border crossers survive the journey, but some develop life-threatening medical complications. Such complications have been subject to little formal analysis. We sought to determine the causes of critical illness in this population and to analyze the hospital course and outcomes of these patients. We retrospectively identified border crossers admitted to the intensive care units (ICUs) of two major teaching hospitals in southern Arizona. We recorded admitting diagnoses, severity of illness, length of stay, resource use, discharge diagnoses, and mortality. Our investigation identified 55 admissions to adult ICUs between January 1, 2010 and December 31, 2012. The median age of patients was 27 years. The median hospital length of stay was 7 days, with a median ICU length of stay of 3 days. The median temperature on arrival to the emergency department was 36.8°C. The most common admission diagnoses included trauma (40), rhabdomyolysis (27), acute liver injury (25), dehydration (24), acute kidney injury (19), and encephalopathy (17). Thirteen patients presented with respiratory failure, six patients with severe sepsis, and two with septic shock. A total of 19 patients required ventilator support during their hospital stay, and 30 required at least one surgical intervention. One patient required renal replacement therapy. The median Acute Physiology and Chronic Health Evaluation II score was 6. All but one patient survived to discharge from the hospital. Border crossers are a unique population of young individuals exposed to high temperatures and extreme conditions. Our review of border crosser admissions showed that most patients demonstrated signs of dehydration and leukocytosis, despite a normal median temperature. The median ICU stay was short, despite a high number of patients requiring ventilator support and surgical intervention. Only

  15. Effect of the US-Mexico border region in cardiovascular mortality: ecological time trend analysis of Mexican border and non-border municipalities from 1998 to 2012.

    Science.gov (United States)

    Anaya, Gabriel; Al-Delaimy, Wael K

    2017-05-06

    An array of risk factors has been associated with cardiovascular diseases, and developing nations are becoming disproportionately affected by such diseases. Cardiovascular diseases have been reported to be highly prevalent in the Mexican population, but local mortality data is poor. The Mexican side of the US-Mexico border has a culture that is closely related to a developed nation and therefore may share the same risk factors of cardiovascular diseases. We wanted to explore if there was higher cardiovascular mortality in the border region of Mexico compared to the rest of the nation. We conducted a population based cross-sectional time series analysis to estimate the effects of education, insurance and municipal size in Mexican border (n = 38) and non-border municipalities (n = 2360) and its association with cardiovascular age-adjusted mortality rates between the years 1998-2012. We used a mixed effect linear model with random effect estimation and repeated measurements to compare the main outcome variable (mortality rate), the covariates (education, insurance and population size) and the geographic delimiter (border/non-border). Mortality due to cardiovascular disease was consistently higher in the municipalities along the US-Mexico border, showing a difference of 78 · 5 (95% CI 58 · 7-98 · 3, p Insurance coverage showed an increase in cardiovascular mortality of 3 · 6 (95% CI 3 · 1-4 · 0, p Mexico border region is disproportionately affected by cardiovascular disease mortality as compared to the non-border region of Mexico. This was not explained by education, population density, or insurance coverage. Proximity to the US culture and related diet and habits can be explanations of the increasing mortality trend.

  16. Who’s Who at the Border? A rights-based approach to identifying human trafficking at international borders

    Directory of Open Access Journals (Sweden)

    Marika McAdam

    2013-09-01

    Full Text Available International borders are widely touted as bastions in the fight against trafficking in persons. This article acknowledges the important role border officials play in preventing human trafficking, but calls for expectations to be tempered by deference to the conceptual complexity of cross-border trafficking and the migration processes involved. The fact that many trafficked victims begin their journeys as irregular or smuggled migrants highlights the challenge posed to border officials in identifying trafficked persons among the people they encounter. Indicators of trafficking generally relate to the exploitation phase, leaving border officials with little guidance as to how persons vulnerable to trafficking can be accurately identified before any exploitation has occurred. Ultimately, this paper advocates a pragmatic rights-based approach in designating anti-trafficking functions to border officials. A rights-based approach to border control acknowledges the core work of border officials as being to uphold border integrity, while ensuring that their performance of this role does not jeopardise the rights of those they intercept nor result in missed opportunities for specialists to identify trafficked persons and other vulnerable people among them.

  17. Characterization of Hospital Residuals

    International Nuclear Information System (INIS)

    Blanco Meza, A.; Bonilla Jimenez, S.

    1997-01-01

    The main objective of this investigation is the characterization of the solid residuals. A description of the handling of the liquid and gassy waste generated in hospitals is also given, identifying the source where they originate. To achieve the proposed objective the work was divided in three stages: The first one was the planning and the coordination with each hospital center, in this way, to determine the schedule of gathering of the waste can be possible. In the second stage a fieldwork was made; it consisted in gathering the quantitative and qualitative information of the general state of the handling of residuals. In the third and last stage, the information previously obtained was organized to express the results as the production rate per day by bed, generation of solid residuals for sampled services, type of solid residuals and density of the same ones. With the obtained results, approaches are settled down to either determine design parameters for final disposition whether for incineration, trituration, sanitary filler or recycling of some materials, and storage politics of the solid residuals that allow to determine the gathering frequency. The study concludes that it is necessary to improve the conditions of the residuals handling in some aspects, to provide the cleaning personnel of the equipment for gathering disposition and of security, minimum to carry out this work efficiently, and to maintain a control of all the dangerous waste, like sharp or polluted materials. In this way, an appreciable reduction is guaranteed in the impact on the atmosphere. (Author) [es

  18. Inverting the Telescope on Borders that Matter: Conversations in Café Europa

    DEFF Research Database (Denmark)

    Andersen, Dorte Jagetic; Kramsch, Olivier Thomas; Sandberg, Marie

    2017-01-01

    and questions the often taken for granted relationships between borders, borderers and the bordered. While each chapter concentrates on a different (but overlapping) border issue or perspective, they are united through their focus on the level of everyday bordering practices and experiences, as well...

  19. Cross-Border Patent Disputes: Unified Patent Court or International Commercial Arbitration?

    Directory of Open Access Journals (Sweden)

    Ana Alba Betancourt

    2016-04-01

    Full Text Available Currently, the enforcement of a patent that is registered in several countries involves the risk of getting different and conflicting decisions from the national courts. In 2013, 25 European countries entered in an agreement that aims to homogenise the patent system by creating the European patent with unitary effect and a Unified Patent Court (UPC. This article focuses on the UPC, which aims to have a single court proceeding for cross-border patent conflicts. Does the UPC system represent an advantage compared to the current litigation system? The paper argues that it does and explores what it considers to be the two main advantages of a UPC over the current system of cross-border litigation of patents: the ability to drag several conflicts to a single procedure and the neutrality of the decision makers. These advantages are consequently compared to the characteristics of arbitration. Then, an explanation is provided with regards to how the UPC system is going to work in terms of jurisdiction, preliminary injunctions, the choice of law and enforcement of decisions, comparing those same procedural aspects to arbitration. The article finds that arbitration involves many of the same advantages (as compared to the UPC and that the procedural issues studied in both means are, so too, similar. Therefore, arbitration represents a viable alternative to the UPC when it comes to reducing the risks in solving cross-border patent conflicts.

  20. Highly macroscopically degenerated single-point ground states as source of specific heat capacity anomalies in magnetic frustrated systems

    Science.gov (United States)

    Jurčišinová, E.; Jurčišin, M.

    2018-04-01

    Anomalies of the specific heat capacity are investigated in the framework of the exactly solvable antiferromagnetic spin- 1 / 2 Ising model in the external magnetic field on the geometrically frustrated tetrahedron recursive lattice. It is shown that the Schottky-type anomaly in the behavior of the specific heat capacity is related to the existence of unique highly macroscopically degenerated single-point ground states which are formed on the borders between neighboring plateau-like ground states. It is also shown that the very existence of these single-point ground states with large residual entropies predicts the appearance of another anomaly in the behavior of the specific heat capacity for low temperatures, namely, the field-induced double-peak structure, which exists, and should be observed experimentally, along with the Schottky-type anomaly in various frustrated magnetic system.

  1. Frontiers, territoriality and tensions in bordering spaces

    Directory of Open Access Journals (Sweden)

    María Eugenia Comerci

    2012-01-01

    Full Text Available The expansión of the agricultural frontier in the Argentine pampas implied a re-valuation of "bordering" spaces, which were considered "marginal" by capital. This paper aims at interpreting the socio-territorial impact -from both a material and a symbolic level- being caused by the expansión of the productive, business-profile [agricultural and oil] frontier in the center-west of the province of La Pampa. With the interpretative approach provided by qualitative methodologies, we intend to analyze -in a case study- how these frontier expansión processes altered and re-defined the social arena between the years 2000 and 2010, the social construction of the space and the power relations in Chos Malal

  2. [Crossing borders. The motivation of extreme sportsmen].

    Science.gov (United States)

    Opaschowski, H W

    2005-08-01

    In his article "Crossing borders -- the motivation of extreme sportsmen" the author gets systematically to the bottom of the question of why extreme sportsmen voluntarily take risks and endanger themselves. Within the scope of a representative sampling 217 extreme sportsmen -- from the fields of mountain biking, trekking and free climbing, canoyning, river rafting and deep sea diving, paragliding, parachuting, bungee jumping and survival training -- give information about their personal motives. What fascinates them? The attraction of risk? The search for sensation? Or the drop out of everyday life? And what comes afterwards? Does in the end the whole life become an extreme sport? Fact is: they live extremely, because they want to move beyond well-trodden paths. To escape the boredom of everyday life they are searching for the kick, the thrill, the no-limit experience. It's about calculated risk between altitude flight and deep sea adventure.

  3. Globalization and Cross-Border Labor Organizing

    Directory of Open Access Journals (Sweden)

    Ralph Armbruster

    2015-08-01

    Full Text Available The globalization of the world economy has opened up new possibilities for cross-border labor organizing. In fact, several U.S. unions are working together with unions from Mexico, Honduras, Guatemala, the Dominican Republic, Japan, South Korea, and many European nations. For example, over the last several years, UNITE (Union of Needletrades, Industrial, and Textile Employees, the AFL-CIO, and the international garment workers trade secretariat have worked directly with maquiladora workers in Honduras and the Dominican Republic. These efforts led to the formation of several labor unions and the first contracts ever negotiated in the maquiladoras in the Dominican Republic. In addition, labor rights and solidarity organizations, like the Campaign for Labor Rights, Witness for Peace, and the US/Guatemala Labor Education Project (US/GLEP, along with many other groups, have also played key roles in the formation of maquiladora unions in Nicaragua and Guatemala.

  4. Nuclear Plants in the Vicinity of Borders

    International Nuclear Information System (INIS)

    Wertz, Elmar.

    1979-01-01

    The siting of nuclear power plants in border areas is decided according to 'national criteria' which are governed by the cost/benefit principle, i.e. a comparison between investment and profit; human values are taken into consideration by transforming them into financial values according to the 'quantification' procedure. However ecology cannot be quantified as it is linked to the great complexity of the natural system. To harmonize technical criteria and ecological requirements, the jurist suggests a legal system of indemnity which takes into account both damage which has already occurred and the degree of probability of its occurrence. Thus a new criterion would be introduced in the decision-making process on plant siting: compensation costs for the national population and for the neighbouring countries would then be a factor in cost/benefit calculations. (NEA) [fr

  5. European Enlargement Across Rounds and Beyond Borders

    DEFF Research Database (Denmark)

    Enlargement has been an almost constant part of European integration history – going from an improvised exercise to the EU’s most developed foreign policy tool. However, neither the longevity nor the complexity of enlargement has been properly historicised. European Enlargement across Rounds...... and Beyond Borders offers three interdisciplinary, innovative, and indeed radical, new ways of understanding and analysing EC/EU enlargements: first, tracing Longue Durée developments; second, investigating enlargement Beyond the Road to Membership; and third, exploring the Entangled Exchanges and synergies...... scholars, should engage with it. This publication will be of key interest to scholars and students of modern European history and politics, the European integration process, EU studies, and more broadly multilateral international institutions, history, law and the social sciences....

  6. Cross border mobility of nurse educators: Case studies from ...

    African Journals Online (AJOL)

    The purpose of the study was to raise awareness on cross border mobility of nurse educators and draw on Foucault's analysis to conceptualise the means by which cross border migration of nurse educators could be revisited. A case study design of seven nurse educators who had migrated and came back to their countries ...

  7. The Lessons of the Border War | Scholtz | Scientia Militaria: South ...

    African Journals Online (AJOL)

    A quarter of a century after the end of the Border War, the SANDF's institutional memory of the conflict is slowly fading. And yet there are several ... about war as well. Key words: Border War, SADF, SANDF, combined arms, reserve force, Operation Savannah, Operation Moduler, mobile warfare doctrine, military education ...

  8. 75 FR 70937 - U.S. Customs and Border Protection

    Science.gov (United States)

    2010-11-19

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Accreditation and Approval of... Protection, Department of Homeland Security. ACTION: Notice of accreditation and approval of Robinson... Border Protection to conduct the specific test or gauger service requested. Alternatively, inquires...

  9. 77 FR 38076 - U.S. Customs and Border Protection

    Science.gov (United States)

    2012-06-26

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Accreditation and Approval of... Protection, Department of Homeland Security. ACTION: Notice of accreditation and approval of SGS North... and Border Protection to conduct the specific test or gauger service requested. Alternatively...

  10. The Refugee Crisis, Non-Citizens, Border Politics and Education

    Science.gov (United States)

    Gerrard, Jessica

    2017-01-01

    In the midst of the most serious refugee crisis since WWII, nation states are buttressing their borders. This paper explores the border politics of the nation state in response to the refugee crisis. Drawing on the work of Susan Sontag, Judith Butler and Imogen Tyler it considers the ways in which the imagery of the pain and suffering of Others is…

  11. Geology of the border region between Coahuila and Zacatecas, Mexico

    NARCIS (Netherlands)

    Vloten, van Roger

    1954-01-01

    The border region between Coahuila and Zacatecas is part of the mountainous country south of Parras in northeastern Mexico. It includes a thickness of about 2,600 meters of Jurassic and Cretaceous rocks that were deposited along the northern border of the Mexican geosyncline along the southern

  12. On the assessment of cross-border regions' development potential

    Directory of Open Access Journals (Sweden)

    Bilchak Mikhail

    2011-06-01

    Full Text Available This article sets out to assess the potential of cross-border region development on the basis of theoretical and methodological materials. The study examines the Kaliningrad region and Warmian-Masurian Voivodeship. The article is focused on the modelling of interindustry balance and export/import functions of border territories.

  13. 15 CFR 30.17 - Customs and Border Protection regulations.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Customs and Border Protection regulations. 30.17 Section 30.17 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... Requirements § 30.17 Customs and Border Protection regulations. Refer to the DHS's CBP regulations, 19 CFR 192...

  14. Permeability of Czech-Polish Border Using by Selected Criteria

    Czech Academy of Sciences Publication Activity Database

    Kolejka, Jaromír; Zyszkowska, K.; Batelková, Kateřina; Ciok, S.; Dolzblasz, K.; Kirchner, Karel; Krejčí, Tomáš; Raczyk, A.; Spaller, W.; Zapletalová, Jana

    2015-01-01

    Roč. 10, č. 1 (2015), s. 51-65 ISSN 1842-5135 Institutional support: RVO:68145535 Keywords : natural barrier * cross border co-operation * population pressure * border segments * Poland and Czech Republic Subject RIV: DE - Earth Magnetism, Geodesy, Geography http://technicalgeography.org/pdf/1_2015/06_kolejka.pdf

  15. Cross-border insolvencies as a global economic problem | Stander ...

    African Journals Online (AJOL)

    As a result of the continuing expansion of international trade and investment, there has been an increase in the occurrence of cross-border insolvencies. National insolvency laws have not kept pace with the trend, and there is a need to develop an efficient and fair system for the administration of cross-border insolvencies.

  16. Cross-Border Banking in Europe : What's Next?

    NARCIS (Netherlands)

    Allen, F.; Beck, T.H.L.; Carletti, E.; Lane, P.; Schoenmaker, D.; Wagner, W.B.

    2011-01-01

    Understanding the role of banks in cross-border finance has become an urgent priority. Cross-border banks have played a central role in the dynamics of the global crisis of 2007-2009. First, European banks had a surprisingly large exposure to the US securitised asset markets, which arose to a

  17. Cross border reproductive care in six European countries

    DEFF Research Database (Denmark)

    de Mouzon, J; Pennings, G; Ferraretti, A P

    2010-01-01

    The quantity and the reasons for seeking cross border reproductive care are unknown. The present article provides a picture of this activity in six selected European countries receiving patients.......The quantity and the reasons for seeking cross border reproductive care are unknown. The present article provides a picture of this activity in six selected European countries receiving patients....

  18. Male preventive health behaviors: perceptions from men, women, and clinical staff along the U.S. Mexico border.

    Science.gov (United States)

    Hunter, Jennifer B; Fernandez, Maria Lourdes; Lacy-Martinez, Charles R; Dunne-Sosa, Andrea M; Coe, M Kathryn

    2007-12-01

    Mexican American males have higher levels of total cholesterol and triglycerides, higher body mass indexes, and a higher prevalence of diabetes than do non-Hispanic White males. They are the least likely Hispanic subgroup to be insured, to have recently visited a physician, or to have preventive exams. To explore factors related to the use of preventive exams among mature men, and specifically among Mexican American men residing along the Arizona, United States/Sonora, Mexico border, information on barriers and motivating factors to male participation in preventive screening exams was collected. Interviews were conducted with mature men and women from a single border community and with clinical staff from three different border communities who deliver services to similar populations. Responses were triangulated. Common themes identified include health education/information/advertisement and female/family support as motivating factors and machismo/denial/fatalism as a barrier to male health-seeking behavior.

  19. Interactions of a didomain fragment of the Drosophila Sex-lethal protein with single-stranded uridine-rich oligoribonucleotides derived from the transformer and Sex-lethal messenger RNA precursors: NMR with residue-selective [5-2H]uridine substitutions

    International Nuclear Information System (INIS)

    Kim, Insil; Muto, Yutaka; Watanabe, Satoru; Kitamura, Aya; Futamura, Yasuhiro; Yokoyama, Shigeyuki; Hosono, Kazumi; Kawai, Gota; Takaku, Hiroshi; Dohmae, Naoshi; Takio, Koji; Sakamoto, Hiroshi; Shimura, Yoshiro

    2000-01-01

    Proteins that contain two or more copies of the RNA-binding domain [ribonucleoprotein (RNP) domain or RNA recognition motif (RRM)] are considered to be involved in the recognition of single-stranded RNA, but the mechanisms of this recognition are poorly understood at the molecular level. For an NMR analysis of a single-stranded RNA complexed with a multi-RBD protein, residue-selective stable-isotope labeling techniques are necessary, rather than common assignment methods based on the secondary structure of RNA. In the present study, we analyzed the interaction of a Drosophila Sex-lethal (Sxl) protein fragment, consisting of two RBDs (RBD1-RBD2), with two distinct target RNAs derived from the tra and Sxl mRNA precursors with guanosine and adenosine, respectively, in a position near the 5'-terminus of a uridine stretch. First, we prepared a [5- 2 H]uridine phosphoramidite, and synthesized a series of 2 H-labeled RNAs, in which all of the uridine residues except one were replaced by [5- 2 H]uridine in the target sequence, GU 8 C. By observing the H5-H6 TOCSY cross peaks of the series of 2 H-labeled RNAs complexed with the Sxl RBD1-RBD2, all of the base H5-H6 proton resonances of the target RNA were unambiguously assigned. Then, the H5-H6 cross peaks of other target RNAs, GU 2 GU 8 , AU 8 , and UAU 8 , were assigned by comparison with those of GU 8 C. We found that the uridine residue prior to the G or A residue is essential for proper interaction with the protein, and that the interaction is tighter for A than for G. Moreover, the H1' resonance assignments were achieved from the H5-H6 assignments. The results revealed that all of the protein-bound nucleotide residues, except for only two, are in the unusual C2'-endo ribose conformation in the complex

  20. Interactions of a didomain fragment of the Drosophila Sex-lethal protein with single-stranded uridine-rich oligoribonucleotides derived from the transformer and Sex-lethal messenger RNA precursors: NMR with residue-selective [5-2H]uridine substitutions

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Insil; Muto, Yutaka; Watanabe, Satoru; Kitamura, Aya; Futamura, Yasuhiro; Yokoyama, Shigeyuki [University of Tokyo, Department of Biophysics and Biochemistry, Graduate School of Science (Japan); Hosono, Kazumi; Kawai, Gota; Takaku, Hiroshi [Chiba Institute of Technology, Department of Industrial Chemistry (Japan); Dohmae, Naoshi; Takio, Koji [Institute of Physical and Chemical Research (RIKEN) (Japan); Sakamoto, Hiroshi [Kobe University, Department of Biology, Faculty of Science (Japan); Shimura, Yoshiro [Biomolecular Engineering Research Institute (Japan)

    2000-06-15

    Proteins that contain two or more copies of the RNA-binding domain [ribonucleoprotein (RNP) domain or RNA recognition motif (RRM)] are considered to be involved in the recognition of single-stranded RNA, but the mechanisms of this recognition are poorly understood at the molecular level. For an NMR analysis of a single-stranded RNA complexed with a multi-RBD protein, residue-selective stable-isotope labeling techniques are necessary, rather than common assignment methods based on the secondary structure of RNA. In the present study, we analyzed the interaction of a Drosophila Sex-lethal (Sxl) protein fragment, consisting of two RBDs (RBD1-RBD2), with two distinct target RNAs derived from the tra and Sxl mRNA precursors with guanosine and adenosine, respectively, in a position near the 5'-terminus of a uridine stretch. First, we prepared a [5-{sup 2}H]uridine phosphoramidite, and synthesized a series of {sup 2}H-labeled RNAs, in which all of the uridine residues except one were replaced by [5-{sup 2}H]uridine in the target sequence, GU{sub 8}C. By observing the H5-H6 TOCSY cross peaks of the series of {sup 2}H-labeled RNAs complexed with the Sxl RBD1-RBD2, all of the base H5-H6 proton resonances of the target RNA were unambiguously assigned. Then, the H5-H6 cross peaks of other target RNAs, GU{sub 2}GU{sub 8}, AU{sub 8}, and UAU{sub 8}, were assigned by comparison with those of GU{sub 8}C. We found that the uridine residue prior to the G or A residue is essential for proper interaction with the protein, and that the interaction is tighter for A than for G. Moreover, the H1' resonance assignments were achieved from the H5-H6 assignments. The results revealed that all of the protein-bound nucleotide residues, except for only two, are in the unusual C2'-endo ribose conformation in the complex.

  1. Cross-Border Brides: Vietnamese Wives, Chinese Husbands in a Border-Area Fishing Village

    Directory of Open Access Journals (Sweden)

    Nguyễn Thị Phương Châm

    2014-06-01

    Full Text Available This article traces the lives of a group of Vietnamese women driven by poverty and loss of marriageability to cross the border into China to marry men from the fishing village of Wanwei. Wanwei’s location, only 25 kilometers from the border with Vietnam, enables these women to make fairly regular trips back to their native villages to visit their birth families. Yet, despite the fact that they now live in a designated Jing (ethnic Vietnamese village, where a significant proportion of the population shares their ethnicity, their illegal residential status and recent arrival excludes them from the community of villagers who claim descent from Vietnamese immigrants in the sixteenth century. Despite the hardships these women face as a result of continuing poverty, lack of emotional intimacy in their marriages, and marginal social status, few see themselves as victims of human trafficking. Instead, most take pride in their agency and achievements.

  2. Parhelic-like circle from light scattering in Plateau borders

    Energy Technology Data Exchange (ETDEWEB)

    Tufaile, A., E-mail: tufaile@usp.br; Tufaile, A.P.B.

    2015-03-06

    We are reporting a new simple optical element to generate halos. We have observed interesting patterns of light scattering in Plateau borders in foams. In analogy to the atmospheric phenomena known as parhelic circle, sun dogs, and sun pillars, we have named the features of the patterns observed as parlaseric circle, laser dogs, and laser pillars. The triangular symmetry of the Plateau borders is analogous to the hexagonal symmetry of ice crystals which produce these atmospheric phenomena. Working with one Plateau border at a time, we have observed wave optics phenomena that are not perceived in the atmospheric phenomena, such as diffraction and interference. - Highlights: • We obtained halo formation from light scattering in a Plateau border using an experiment. • We explained halo formation using geometrical theory of diffraction. • An optical element based on a Plateau border is proposed. • We compared some aspects of the parhelic circle with the parlaseric circle.

  3. Does smoke cross the border? Cigarette tax avoidance in France.

    Science.gov (United States)

    Ben Lakhdar, Christian; Vaillant, Nicolas Gérard; Wolff, François-Charles

    2016-12-01

    This paper examines the impact on cigarette sales of the successive increases in cigarette prices in France from 2002 to 2004. Since the price differential between France and neighboring countries increased over the period in question, cross-border purchases became more financially attractive for smokers living near borders. Results from difference-in-differences estimates indicate that the decrease in cigarette sales observed in French border departments was around 20 % higher from 2004 to 2007 compared to non-border departments. The loss of fiscal revenue due to cross-border shopping since the tax increase amounts to 2 billion euros over the period 2002-2007. Our findings highlight the need for improved coordination of policies aimed at reducing tobacco consumption across European Union countries.

  4. Fast and slow border traps in MOS devices

    International Nuclear Information System (INIS)

    Fleetwood, D.M.

    1996-01-01

    Convergent lines of evidence are reviewed which show that near-interfacial oxide traps (border traps) that exchange charge with the Si can strongly affect the performance, radiation response, and long-term reliability of MOS devices. Observable effects of border traps include capacitance-voltage (C-V) hysteresis, enhanced l/f noise, compensation of trapped holes, and increased thermally stimulated current in MOS capacitors. Effects of faster (switching times between ∼10 -6 s and ∼1 s) and slower (switching times greater than ∼1 s) border traps have been resolved via a dual-transistor technique. In conjunction with studies of MOS electrical response, electron paramagnetic resonance and spin dependent recombination studies suggest that E' defects (trivalent Si centers in SiO 2 associated with O vacancies) can function as border traps in MOS devices exposed to ionizing radiation or high-field stress. Hydrogen-related centers may also be border traps

  5. Cross-Border Tourism and its Significance for Tourism Destinations

    Directory of Open Access Journals (Sweden)

    Roman LIVANDOVSCHI

    2017-06-01

    Full Text Available This article is concerned with cross-border tourism. It enhances the importance of cross-border cooperation in tourism. Cross-border cooperation is a form of international cooperation, along with interregional, transitional and trans-frontier cooperation. Cross-border regions often share the same historical and cultural traditions and attractive natural landscapes, such is the case of the Republic of Moldova and Romania. In both cases, cross-border regions can benefit from cooperation – cooperation can help create greater diversity and differentiation of the range of tourism and environmental products; create economies of scale and make promotion more effective, and can help better address specific problems or issues for tourism development.

  6. [The Swiss border veterinary service in the 20th century].

    Science.gov (United States)

    Schluep, J

    2018-01-01

    The first animal disease act of Switzerland was released in 1872. Its revision in 1886 brought the basis for establishing a border veterinary inspection service. This service was first reporting to the federal Ministry of Agriculture; after 1914, the newly created Federal Veterinary Office became responsible for it. The border checks were first limited to live biungulate animals and horses; later on they were extended to meat and meat products and finally to venison and fishery products. At the beginning, part-time veterinarians with own practice were engaged. As the traffic increased, full time border veterinary inspectors joined the team; these were mainly active at the most important border posts (like Basel, St. Margrethen, Buchs, Chiasso, Geneva, more recently the international airports). The border veterinary inspection service, including the relevant instruction of the personnel, was (and is) financed with weight depending fees which included until 1966 a fee intended for financing the efforts to control livestocks epidemics.

  7. Rethinking Borders in Japan: Internal, Cultural, and Geopolitical

    Directory of Open Access Journals (Sweden)

    Ingyu Oh

    2016-03-01

    Full Text Available Christopher Bondy. Voice, Silence, and Self: Negotiations of Buraku Identity in Contemporary Japan. Cambridge, MA: Harvard University Asia Center, 2015. 184 pp. $40 (cloth. Koichi Iwabuchi. Resilient Borders and Cultural Diversity. Lanham, MD: Lexington Books, 2015. 137 pp. $75 (cloth/e-book. Akihiro Iwashita. Japan’s Border Issues: Pitfalls and Prospects. New York: Routledge, 2016. 144 pp. $160 (cloth. The books reviewed here address three different borders in present-day Japanese society: internal, cultural, and geopolitical. It is rare for three different authors to concurrently publish monographs on Japanese borders from three different angles. This may be a sign of increasing consciousness within Japan on the issues of diversity, multiethnicity, old and new forms of discrimination, and continuing border conflicts with neighboring countries...

  8. Management of NORM Residues

    International Nuclear Information System (INIS)

    2013-06-01

    The IAEA attaches great importance to the dissemination of information that can assist Member States in the development, implementation, maintenance and continuous improvement of systems, programmes and activities that support the nuclear fuel cycle and nuclear applications, and that address the legacy of past practices and accidents. However, radioactive residues are found not only in nuclear fuel cycle activities, but also in a range of other industrial activities, including: - Mining and milling of metalliferous and non-metallic ores; - Production of non-nuclear fuels, including coal, oil and gas; - Extraction and purification of water (e.g. in the generation of geothermal energy, as drinking and industrial process water; in paper and pulp manufacturing processes); - Production of industrial minerals, including phosphate, clay and building materials; - Use of radionuclides, such as thorium, for properties other than their radioactivity. Naturally occurring radioactive material (NORM) may lead to exposures at some stage of these processes and in the use or reuse of products, residues or wastes. Several IAEA publications address NORM issues with a special focus on some of the more relevant industrial operations. This publication attempts to provide guidance on managing residues arising from different NORM type industries, and on pertinent residue management strategies and technologies, to help Member States gain perspectives on the management of NORM residues

  9. School Social Workers in Texas: A Comparative Demographic Analysis of the Texas-Mexico Border and Non-Border Regions

    Science.gov (United States)

    Garza, Cecilia; Landeck, Michael

    2007-01-01

    This study examines the role of school social workers as potential agents of change in the educational system, with a special focus on their major demographic characteristics in Texas and along the Mexico border region. The border region of the state has chronic poverty and limited educational attainment levels and demonstrates a need for…

  10. Symmetry or asymmetry? Cross-border openness of service providers in Polish-Czech and Polish-German border towns

    Directory of Open Access Journals (Sweden)

    Dołzbłasz Sylwia

    2015-03-01

    Full Text Available The symmetry and/or asymmetry in terms of cross-border openness of service providers is examined in this article, for the cases of two border twin towns: Cieszyn/Český Těšín at the Polish-Czech border, and Gubin/Guben at the Polish-German border. To assess the level of openness of firms towards clients from the other side of the border, four trans-border categories were examined: neighbour’s language visible at store location; business offers in the language of the neighbour; the possibilities of payment in the neighbour’s currency; and the staff’s knowledge of the language. This enabled a comparison of both parts of the particular twin towns in relation to the character of cross-border openness, as well as an assessment of their symmetry/asymmetry. Comparisons of Gubin/Guben and Cieszyn/Český Těšín with respect to the analysed features were also carried out. The analysis shows significant variation in the level of cross-border openness towards clients from neighbouring countries. Whereas in the Polish-Czech town a relative symmetry was observed, in the Polish-German case, significant asymmetry was noted.

  11. Experiences in Regional Cross Border Co-operation in River Management. Comparing Three Cases at the Dutch–German Border

    NARCIS (Netherlands)

    Wiering, M.A.; Verwijmeren, J.A.; Lulofs, K.; Feld, C.

    2010-01-01

    Cross border co-operation is increasingly viewed as an obvious and logical consequence of an integrated perspective on river management. Consequently, we would expect an increase of cross border co-operation and collaboration in EU member states, through joint planning, co-management or

  12. The Humanitarian Drone and the Borders: Unveiling the Rationales Underlying the Deployment of Drones in Border Surveillance

    NARCIS (Netherlands)

    Marin, Luisa; Custers, Bart

    2016-01-01

    In these days economic and political pressures push for the deployment of drones’ technology in civil and commercial domains. This chapter focuses in particular on the deployment of drones in the context of border surveillance. Border surveillance is a shared competence between the European Union,

  13. Cooperative Monitoring Center Occasional Paper/7: A Generic Model for Cooperative Border Security

    Energy Technology Data Exchange (ETDEWEB)

    Netzer, Colonel Gideon

    1999-03-01

    This paper presents a generic model for dealing with security problems along borders between countries. It presents descriptions and characteristics of various borders and identifies the threats to border security, while emphasizing cooperative monitoring solutions.

  14. Residual-stress measurements

    Energy Technology Data Exchange (ETDEWEB)

    Ezeilo, A N; Webster, G A [Imperial College, London (United Kingdom); Webster, P J [Salford Univ. (United Kingdom)

    1997-04-01

    Because neutrons can penetrate distances of up to 50 mm in most engineering materials, this makes them unique for establishing residual-stress distributions non-destructively. D1A is particularly suited for through-surface measurements as it does not suffer from instrumental surface aberrations commonly found on multidetector instruments, while D20 is best for fast internal-strain scanning. Two examples for residual-stress measurements in a shot-peened material, and in a weld are presented to demonstrate the attractive features of both instruments. (author).

  15. Detection of radioactive materials at borders

    International Nuclear Information System (INIS)

    2003-08-01

    of Understanding (MOU) (1998) to promote co-operation at the international level in order to improve the control of radioactive materials. At the time of the drafting of this report, a similar MOU between the IAEA and the International Criminal Police Organization (INTERPOL) is pending. There are a number of measures that must be undertaken by States to combat the illicit trafficking and inadvertent movements of radioactive materials. These measures are, generally, shared between the regulatory and law enforcement agencies as part of a State's national arrangements. One of these measures id the subject of this TECDOC, namely detection of radioactive materials at borders. While effective detection involves many components of regulatory and law enforcement strategies, the major focus of this publication is on radiation detection and in particular, the instrumentation necessary for such purposes. Its intent is to assist Member State organizations in effectively detecting radioactive materials crossing their borders, whether importations, exportations, or shipments in transit. The purpose of this publication is to provide guidance for Member States for use by customs, police or other law enforcement bodies on the radiation monitoring of vehicles, people and commodities at border crossing facilities as a countermeasure to illicit trafficking and also to find inadvertent movement of radioactive materials. Such monitoring may be one component of efforts towards finding radioactive materials that have been lost from control and which may enter a Member State

  16. Detection of radioactive materials at borders

    International Nuclear Information System (INIS)

    2002-09-01

    of Understanding (MOU) (1998) to promote co-operation at the international level in order to improve the control of radioactive materials. At the time of the drafting of this report, a similar MOU between the IAEA and the International Criminal Police Organization (INTERPOL) is pending. There are a number of measures that must be undertaken by States to combat the illicit trafficking and inadvertent movements of radioactive materials. These measures are, generally, shared between the regulatory and law enforcement agencies as part of a State's national arrangements. One of these measures id the subject of this TECDOC, namely detection of radioactive materials at borders. While effective detection involves many components of regulatory and law enforcement strategies, the major focus of this publication is on radiation detection and in particular, the instrumentation necessary for such purposes. Its intent is to assist Member State organizations in effectively detecting radioactive materials crossing their borders, whether importations, exportations, or shipments in transit. The purpose of this publication is to provide guidance for Member States for use by customs, police or other law enforcement bodies on the radiation monitoring of vehicles, people and commodities at border crossing facilities as a countermeasure to illicit trafficking and also to find inadvertent movement of radioactive materials. Such monitoring may be one component of efforts towards finding radioactive materials that have been lost from control and which may enter a Member State

  17. Detection of radioactive materials at borders

    International Nuclear Information System (INIS)

    2004-05-01

    of Understanding (MOU) (1998) to promote co-operation at the international level in order to improve the control of radioactive materials. At the time of the drafting of this report, a similar MOU between the IAEA and the International Criminal Police Organization (INTERPOL) is pending. There are a number of measures that must be undertaken by States to combat the illicit trafficking and inadvertent movements of radioactive materials. These measures are, generally, shared between the regulatory and law enforcement agencies as part of a State's national arrangements. One of these measures id the subject of this TECDOC, namely detection of radioactive materials at borders. While effective detection involves many components of regulatory and law enforcement strategies, the major focus of this publication is on radiation detection and in particular, the instrumentation necessary for such purposes. Its intent is to assist Member State organizations in effectively detecting radioactive materials crossing their borders, whether importations, exportations, or shipments in transit. The purpose of this publication is to provide guidance for Member States for use by customs, police or other law enforcement bodies on the radiation monitoring of vehicles, people and commodities at border crossing facilities as a countermeasure to illicit trafficking and also to find inadvertent movement of radioactive materials. Such monitoring may be one component of efforts towards finding radioactive materials that have been lost from control and which may enter a Member State

  18. Environmental exposure of road borders to zinc

    Energy Technology Data Exchange (ETDEWEB)

    Blok, J. [Royal Haskoning, P.O. Box 151, 6500 Ad Nijmegen (Netherlands)]. E-mail: Han.Blok@royalhaskoning.com

    2005-09-15

    The emissions of zinc along roads originating from tyre wear, corrosion of safety fence and other traffic-related sources have been quantified and validated by measured long-term loads in road run-off and airborne solids (drift) for 29 published case studies. The distribution pattern over the road border at various distances from the edge of the paved surface is assessed on the basis of 38 published case studies with measured concentrations in soil. For the impact assessment, the road border is differentiated into a zone that is part of the 'technosphere' and the 'target zone' beyond that technosphere that can be considered as part of the receiving environment. The 'technosphere' of the road includes the central reservation, the hard and the soft shoulder or, if one or both shoulders are not present, the so-called obstacle 'free zone' that is defined by road engineers. Pollution within the technosphere may require appropriate management of solid disposal and isolation from groundwater to prevent further distribution of pollutants to the environment. In the target zone along regional roads, the zinc load is about 4 mg/m{sup 2} year and this is of the same order of magnitude as that of atmospheric deposition in areas beyond the influence of roads (background). In the target zone along highways, the zinc load is increased in comparison to the background deposition. The average load of about 38 mg/m{sup 2} year is similar to that in fertilised agricultural land. Because most of the emitted zinc stays in the technosphere, the total amount entering this target zone along highways is limited. From the 140 tons of zinc per year that is released from tyre wear in The Netherlands, 64 tons is emitted in the urban area, 6.5 tons reaches to the target zones of all roads and only 1.1 tons of zinc will enter the target zone along highways. This amount will be further decreased by the application of porous asphalt in the near future. The

  19. An open mind to closed borders

    Science.gov (United States)

    Fallet, Ulrike; Lefeber, Bob

    2017-04-01

    One aspect of "Science in tomorrow's classroom" is teaching geography students the basic skills and knowledge to play an active role in society as citizens. Topics that frame the development of good citizenship are wide-ranged and include climate change, migration and integration as well as democracy and identity. Often these kinds of topics do not allow for right or wrong answers or classroom lectures; it is more important to encourage students to find and discuss arguments with which to underpin their opinion. In this way, civic education is very suitable for active learning. Active learning is described as a method of learning in which students are actively involved in the learning process through (group) discussion, experiments or games. By doing so, students are stimulated to engage in higher-order thinking tasks such as analysis, synthesis, and evaluation, which are inherent to becoming responsible, reflective and critical citizens as well as (future) scientists. It has also been shown that the use of active learning methods significantly increased the number of meaningful geographical relationships that students give in tests (Karkdijk, 2012). I, therefore, propose to use active learning to approach civic education in the classroom. Specifically, I used a "mystery" to engage students in active learning on the highly polarizing subject of migration. A mystery (Leat, 1990) is a didactic method that uses short bits of information to solve an intriguing question. A current polarizing subject in society and in the classroom is the migration from Northern Africa and the Middle East to Europe and the increasing number of terrorist attacks by individuals who have radicalised before, during or after their journey over the Mediterranean. In class, students were asked to solve this migration mystery: "Could the terrorist attack in Berlin have been stopped by closing the borders of the Mediterranean countries to migrants?" In order to solve this mystery and to find an

  20. Environmental exposure of road borders to zinc

    International Nuclear Information System (INIS)

    Blok, J.

    2005-01-01

    The emissions of zinc along roads originating from tyre wear, corrosion of safety fence and other traffic-related sources have been quantified and validated by measured long-term loads in road run-off and airborne solids (drift) for 29 published case studies. The distribution pattern over the road border at various distances from the edge of the paved surface is assessed on the basis of 38 published case studies with measured concentrations in soil. For the impact assessment, the road border is differentiated into a zone that is part of the 'technosphere' and the 'target zone' beyond that technosphere that can be considered as part of the receiving environment. The 'technosphere' of the road includes the central reservation, the hard and the soft shoulder or, if one or both shoulders are not present, the so-called obstacle 'free zone' that is defined by road engineers. Pollution within the technosphere may require appropriate management of solid disposal and isolation from groundwater to prevent further distribution of pollutants to the environment. In the target zone along regional roads, the zinc load is about 4 mg/m 2 year and this is of the same order of magnitude as that of atmospheric deposition in areas beyond the influence of roads (background). In the target zone along highways, the zinc load is increased in comparison to the background deposition. The average load of about 38 mg/m 2 year is similar to that in fertilised agricultural land. Because most of the emitted zinc stays in the technosphere, the total amount entering this target zone along highways is limited. From the 140 tons of zinc per year that is released from tyre wear in The Netherlands, 64 tons is emitted in the urban area, 6.5 tons reaches to the target zones of all roads and only 1.1 tons of zinc will enter the target zone along highways. This amount will be further decreased by the application of porous asphalt in the near future. The emission from safety fence corrosion does not enter

  1. The Cosmopolitanization of the EU’s Borders?

    Directory of Open Access Journals (Sweden)

    Damian Spruce

    2007-08-01

    Full Text Available For centuries the political geography of Europe has been based around borders of its nation states. The ability of the nation state to control its territory has been essential to the practices of war and diplomacy, the legitimacy of governments, immigration policies and trade. But processes of globalization and EU integration have transformed the borders of the European nation state. While globalization theorists tend to posit an opening up of borders to global flows of capital, information and people, the changed nature of the border is itself often left unexamined and is assumed to have simply disappeared. But scholars and activists are now arguing that, rather than fading away, borders are proliferating in the globalized world and their functions spreading into many different areas of society. This article examines the transformation of the ‘classical’ border of the nation-state into its recent forms, using the work of theorists such as Balibar, Mezzadra, Rigo and Walters. It then examines how these theories have been applied in recent literature, and in particular Chris Rumford’s analysis of the European Neighbourhood policy and his argument that this represents a ‘cosmopolitanisation’ of European borders.

  2. Designing with residual materials

    NARCIS (Netherlands)

    Walhout, W.; Wever, R.; Blom, E.; Addink-Dölle, L.; Tempelman, E.

    2013-01-01

    Many entrepreneurial businesses have attempted to create value based on the residual material streams of third parties. Based on ‘waste’ materials they designed products, around which they built their company. Such activities have the potential to yield sustainable products. Many of such companies

  3. Market Intergration and Border Effects in Eastern Africa

    OpenAIRE

    Bruno Versailles

    2012-01-01

    This paper studies border efects in Eastern Africa by exploiting a consumer price data set covering 4 out of 5 EAC member states, 39 cities and 24 goods over the period 2004-2008. The Law-of-One-Price (LOP) is tested by running level regressions on relative prices with city-pairs the unit of observation. Unsurprisingly, distance plays an important role in explaining relative price movements, both within and between countries. The border efect as measured by the coef?cient on a border dummy is...

  4. Border Collision Route to Quasiperiodicity: Numerical Investigation and Experimental Confirmation

    DEFF Research Database (Denmark)

    Zhusubaliyev, Zhanybai; Mosekilde, Erik; Maity, S.

    2006-01-01

    Numerical studies of higher-dimensional piecewise-smooth systems have recently shown how a torus can arise from a periodic cycle through a special type of border-collision bifurcation. The present article investigates this new route to quasiperiodicity in the two-dimensional piecewise-linear normal...... form map. We have obtained the chart of the dynamical modes for this map and showed that border-collision bifurcations can lead to the birth of a stable closed invariant curve associated with quasiperiodic or periodic dynamics. In the parameter regions leading to the existence of an invariant closed...... to quasiperiodicity through a border-collision bifurcation. ©2006 American Institute of Physics...

  5. Social and cultural influences among Mexican border entrepreneurs.

    Science.gov (United States)

    Díaz Bretones, Francisco; Cappello, Héctor M; Garcia, Pedro A

    2009-06-01

    Social and cultural conditions (including U.S. border and inland influence, role models within the family, and educational background) which affect locus of control and achievement motivation among Mexican entrepreneurs were explored among 64 selected entrepreneurs in two Mexican towns, one on the Mexico-U.S. border, the other located inland. Analyses showed that the border subsample scored higher on External locus of control; however, in both subsamples the father was an important element in the locus of control variable and the entrepreneur status. No statistically significant mean difference was noted for achievement motivation. Practical applications and limitations are discussed.

  6. CHANGING BORDERS, RETHINKING SOVEREIGNTY: TOWARDS A RIGHT TO MIGRATE

    Directory of Open Access Journals (Sweden)

    Maribel Casas-Cortes

    Full Text Available Abstract The intervention of European Union border authorities in countries of Africa, Asia and Eastern Europe has shown how the European state “border” has been displaced from its national moorings and externalized across the territories of neighboring states. Our research examines the outsourcing of the southern European Union border, focusing on the case of Spain and its relationship with Morocco and countries of Western Africa. In this paper we describe the development and implementation of this strategy of migration management, signaling implications of border externalization from the point of geopolitics and legality, including a suggestive call to reclaim the legal tradition of the Right to Migrate.

  7. Satisfaction in border tourism: An analysis with structural equations

    Directory of Open Access Journals (Sweden)

    Juan Antonio Jimber del Río

    2017-05-01

    Full Text Available Border tourism is the temporary displacement of people to the dividing line between two countries contiguous areas. This activity promotes the economic development of these geographical regions. The aim of this research is to analyze visitors from the Dominican Republic and Haiti border. We propose the results of an empirical study with structural equations that show correlations between the attitude factor towards the border tourism, the value factors perceived by the tourist, satisfaction and loyalty of the visitor in the destination place.

  8. Learning from Cross-Border Reproduction

    Science.gov (United States)

    Millbank, Jenni; Karpin, Isabel; Stuhmcke, Anita

    2017-01-01

    Abstract Drawing upon the preliminary findings of an Australian empirical project on cross-border reproduction (CBR), this article argues that regulators and policymakers could learn from the experiences of those who travel overseas in order to access fertility treatment and surrogacy. It makes four principal observations. First, the distinction between so-called ‘altruistic’ and ‘commercial’ gamete donation and surrogacy is increasingly unsustainable and is not experienced as meaningful by many participants in CBR. Secondly, the status of the law in CBR is profoundly equivocal; for participants it is often there and not there at the same time. Thirdly, self-sourced information, from the internet and more specifically social media such as Facebook, is now the principal source of information and peer support for reproductive travellers. Fourthly, and relatedly, domestic reproductive services providers are often sidestepped. If one of the goals of regulation is to minimise the risk of harm to participants, it is not clear that it is currently achieving this aim, and this article argues that any reforms will only work if they are more responsive to the reality of CBR. PMID:28073821

  9. Contributions for studies’ epistemology regarding international borders

    Directory of Open Access Journals (Sweden)

    Eusebio Medina García

    2006-01-01

    Full Text Available In this paper, we propose an interpretative model to be used from an interdisciplinary perspective when undertaking international border studies. Inspired by the theory of social dynamic fields (Sztompka, 1995, this model is articulated in four basic dimensions: ideational, normative, materialist and agentive. The model is both dynamic and interactive; it presupposes the existence of multiple and complex relationships among the four field dimensions, as well as a certain degree of autonomy in each one. The model is also governed by two fundamental vectors: space and time. The spatial dimension refers to the physical and material base, as well as the territorial, and to other aspects such as the psychological apprehension of space and of imaginary space. It its temporal, or historical, dimension, we consider the model to be in constant evolution, on an oneness basis, to the extent that it can be studied as a social fact. We stress the need to construct an eclectic methodology in order to reach a balanced conjunction among various aspects: the tangible and intangible, quantitative and qualitative, interpretive and comprehensive singular and shared, functional and rational-critical.

  10. Learning from Cross-Border Reproduction.

    Science.gov (United States)

    Jackson, Emily; Millbank, Jenni; Karpin, Isabel; Stuhmcke, Anita

    2017-02-01

    Drawing upon the preliminary findings of an Australian empirical project on cross-border reproduction (CBR), this article argues that regulators and policymakers could learn from the experiences of those who travel overseas in order to access fertility treatment and surrogacy. It makes four principal observations. First, the distinction between so-called 'altruistic' and 'commercial' gamete donation and surrogacy is increasingly unsustainable and is not experienced as meaningful by many participants in CBR. Secondly, the status of the law in CBR is profoundly equivocal; for participants it is often there and not there at the same time. Thirdly, self-sourced information, from the internet and more specifically social media such as Facebook, is now the principal source of information and peer support for reproductive travellers. Fourthly, and relatedly, domestic reproductive services providers are often sidestepped. If one of the goals of regulation is to minimise the risk of harm to participants, it is not clear that it is currently achieving this aim, and this article argues that any reforms will only work if they are more responsive to the reality of CBR. © The Author 2017. Published by Oxford University Press.

  11. Extrahepatic biliary atresia in a border collie.

    Science.gov (United States)

    Schulze, C; Rothuizen, J; van Sluijs, F J; Hazewinkel, H A; van den Ingh, T S

    2000-01-01

    Progressive lameness and leg pain were the predominant clinical signs in a 17-week-old male border collie presented for examination. On clinical investigation, extrahepatic cholestasis in association with rickets due to inadequate vitamin D resorption was diagnosed. The dog was treated parenterally with vitamin D and a cholecystoduodenostomy was performed. At 25 days postsurgery the lameness had resolved and bone structure was radiographically normal. However, at six weeks postsurgery, the dog's condition deteriorated rapidly and euthanasia was finally performed at eight weeks postsurgery. At postmortem examination, Toxocara canis nematodes were found to have invaded the biliary system via the anastomosis between the gallbladder and duodenum, causing biliary and hepatic toxocariasis. The cause of the primary extrahepatic cholestasis was atresia of the common bile duct at the hepatic end. The liver tissue showed microscopic lesions of chronic extrahepatic cholestasis as well as acute inflammation associated with the nematode invasion. There was no postmortem evidence of bone lesions. Extrahepatic biliary atresia is extremely rare in animals and has not been described before in dogs. In contrast, it represents the most common cause of congenital cholestasis in children, occurring in approximately one per 10,000 to 15,000 live births.

  12. Structure and headship of northern border homes in the last decade

    Directory of Open Access Journals (Sweden)

    Eunice D. Vargas Valle

    2013-01-01

    Full Text Available The objective of this study was to describe the trends in household structure and female headship on the northern border of Mexico between 2000 and 2010, as well as the changes in their demographic profiles. There were three relevant trends: the increase in single person households, the slight decrease in extended households and the rise in female headship. These trends indicate the intersection of complex structural and conjunctural processes. On the one hand, population aging is an ongoing process, and the cultural processes linked to the value of individual autonomy versus familial altruism continue advancing as seen by the rise in men living alone and women heading households. On the other hand, conjunctural processes such as the economic crises and the recent migratory and security policies of the United States have influenced the reduction of internal immigration to the border and the increase of return migration from this country, which in turn have contributed to modifying the composition of border households.

  13. Scent marking in a territorial African antelope: I. The maintenance of borders between male oribi.

    Science.gov (United States)

    Brashares; Arcese

    1999-01-01

    Scent marking is ubiquitous among the dwarf antelope and gazelles of Africa, but its function has been the subject of debate. This study examined preorbital gland scent marking in the oribi, Ourebia ourebi, a territorial African antelope. Several hypotheses for the function of scent marking by territorial antelope were tested with observational data. Of these, the hypotheses that scent marking is driven by intrasexual competition between neighbouring males, and that marks serve as an honest advertisement of a male's ability to defend his territory from rivals, were supported best. Thirty-three territorial male oribi on 23 territories marked most at borders shared with other territorial males, and territorial males marked more often at borders shared with multimale groups than at borders shared with a single male. This suggests that males perceived neighbouring male groups as a greater threat to territory ownership than neighbouring males that defended their territories without the aid of adult subordinates. Marking rate was unrelated to territory size or the number of females on adjacent territories, but males with many male neighbours marked at higher rates than those with fewer male neighbours. These results suggest that the presence of male neighbours has a greater effect on the scent marking behaviour of territorial antelope than has been considered previously. Copyright 1999 The Association for the Study of Animal Behaviour.

  14. Joint malaria surveys lead towards improved cross-border cooperation between Savannakhet province, Laos and Quang Tri province, Vietnam

    Directory of Open Access Journals (Sweden)

    Pongvongsa Tiengkham

    2012-08-01

    Full Text Available Abstract Background In Savannakhet province, Laos and Quang Tri province, Vietnam, malaria is still an important health problem and most cases are found in the mountainous, forested border areas where ethnic minority groups live. The objectives of this study were to obtain a better joint understanding of the malaria situation along the border and, on the basis of that, improve malaria control methods through better cooperation between the two countries. Methods Fourteen villages in Savannakhet and 22 villages in Quang Tri were randomly selected within 5 km from the border where a blood survey for microscopic diagnosis (n = 1256 and n = 1803, respectively, household interviews (n = 400, both sides and vector surveys were conducted between August and October 2010. Satellite images were used to examine the forest density around the study villages. Results Malaria prevalence was significantly higher in Laos (5.2% than in Vietnam (1.8% and many other differences were found over the short distance across the border. Bed net coverage was high (> 90% in both Laos and Vietnam but, while in Laos more than 60% of the nets were long-lasting insecticide-treated, Vietnam used indoor residual spraying in this area and the nets were untreated. Anopheles mosquitoes were more abundant in Laos than in Vietnam, especially many Anopheles dirus were captured in indoor light traps while none were collected in Vietnam. The forest cover was higher around the Lao than the Vietnamese villages. After this study routine exchange of malaria surveillance data was institutionalized and for the first time indoor residual spraying was applied in some Lao villages. Conclusions The abundance of indoor-collected An. dirus on the Laos side raises doubts about the effectiveness of a sole reliance on long-lasting insecticide-treated nets in this area. Next to strengthening the early detection, correct diagnosis and prompt, adequate treatment of malaria infections, it is

  15. Evaluation of residue-residue contact predictions in CASP9

    KAUST Repository

    Monastyrskyy, Bohdan; Fidelis, Krzysztof; Tramontano, Anna; Kryshtafovych, Andriy

    2011-01-01

    This work presents the results of the assessment of the intramolecular residue-residue contact predictions submitted to CASP9. The methodology for the assessment does not differ from that used in previous CASPs, with two basic evaluation measures

  16. Shaping the Victim: Borders, security, and human trafficking in Albania

    Directory of Open Access Journals (Sweden)

    James Campbell

    2013-09-01

    Full Text Available Borders are productive sites where knowledge is gathered and migrant populations are formed. The knowledge gathered from victims of trafficking reinforces a victim narrative that represents a perceived threat to society by highlighting violence, criminality, coercion, and naivety. Using Albania as a case in point, the article looks at trafficked people and the narratives of victimhood that surround them. In the case of trafficked people, the border projected out towards other states produces a discursively defined victim of trafficking. When projected back within the national territory, the border essentially produces a criminalised sex worker. To argue this point, the article discusses the role victims of trafficking play in the EU and looks at how international norms espoused by the OSCE and IOM have prepped the Albanian border for EU ascension and created the means for governable populations within Albania.

  17. Health and Borders across Time and Cultures: Introduction

    Directory of Open Access Journals (Sweden)

    Beatriz Carrillo Garcia

    2011-12-01

    Full Text Available This special issue of Portal brings together papers examining the intersection of health and borders. In this analysis health is understood not only as the absence of illness, but also as knowledge, as a right, and as the pursuit of identity and self-transformation. Similarly, borders here are used as both physical and mental constructs. The special issue represent a multidisciplinary effort that looks at health from a social science perspective through historical, socio-economic, and cultural approaches. It is also concerned with the health inequities across and within national borders, due to economic imperatives, changing technologies and environments. The articles in this special issue explore lessons learned and new ways of understanding health across time and borders, with specific reference to the cases of India, Australia, Hong Kong and China, Pakistan, and Thailand.

  18. Regional trade and border markets between Niger, Benin and Nigeria

    DEFF Research Database (Denmark)

    Walther, Olivier; Tenikué, Michel; Kuepié, Mathias

    The objective of this methodological paper is to identify a number of products or sectors whose trade is relevant for border regions in West Africa. Focusing on Niger, Benin and Nigeria, we start with contextualising the importance of border markets by quantifying the changes in the relative values...... and volumes of imports and exports passing through border posts. In a second step, we determine which are the products most commonly found among the imports and exports of the border posts. The study shows that seven products are recognised as being heavily imported, subject to significant trade from large...... traders, and considered as re-export products: building materials, cereals and flour, textile, used clothing, used vehicles, cigarettes and oil....

  19. Borders in Education and Living- a Case of Trench Warfare.

    Science.gov (United States)

    Hviid, Pernille

    2016-03-01

    In this paper the notion of border will be examined in a cultural life course perspective. I will investigate borders as psycho-cultural constructions created to enable and control meaning-making in the intersection between subjects engagements and concerns and collectively constructed and guiding meanings. An empirical analysis of one boy's life course in and between home, school and a Leisure Time Activity Center in the years 1st to 3rd grade demonstrates a systemic construction of borders involving him, his teachers and his parents and renders the boy to choose between becoming an engaged pupil or a dedicated son. As such, the analysis can illuminate processes of school - home interactions that work opposite of what is intended and become detrimental to children's life. In a cultural life course perspective borders show how life is maintained as meaningful and not only guide the present living but also serve as directional guides into the future.

  20. Status of mangroves along the countries bordering the Arabian Sea

    Digital Repository Service at National Institute of Oceanography (India)

    Untawale, A.G.; Wafar, S.; Jagtap, T.G.

    Distribution of mangroves in the countries bordering the Arabian Sea, including Gulf of Oman, Persian Gulf, Gulf of Aden and Red Sea, is reviewed and their present status is discussed. The estimated area of mangrove vegetation is 1140 sq. km...

  1. Smuggling and cross border shopping of tobacco in Europe.

    Science.gov (United States)

    Joossens, L; Raw, M

    1995-05-27

    Governments have recently become concerned about cross border shopping and smuggling because it can decrease tax revenue. The tobacco industry predicted that, with the removal of border controls in the European Union, price differences between neighbouring countries would lead to a diversion of tobacco trade, legally and illegally, to countries with cheaper cigarettes. According to them this diversion would be through increased cross border shopping for personal consumption or through increased smuggling of cheap cigarettes from countries with low tax to countries with high tax, where cigarettes are more expensive. These arguments have been used to urge governments not to increase tax on tobacco products. The evidence suggests, however, that cross border shopping is not yet a problem in Europe and that smuggling is not of cheap cigarettes to expensive countries. Instead, more expensive "international" brands are smuggled into northern Europe and sold illegally on the streets of the cheaper countries of southern Europe.

  2. Dose distributions of pendulum fields in the field border plane

    International Nuclear Information System (INIS)

    Schrader, R.

    1986-01-01

    Calculations (program SIDOS-U2) and LiF measurements taken in a cylindric water phantom are used to investigate the isodose distributions of different pendulum irradiation methods (Co-60) in a plane which is parallel to the central ray plane and crosses the field borders at the depth of the axis. The dose values compared to the maximum values of the central ray plane are completely different for each pendulum method. In case of monoaxial pendulum methods around small angles, the maximum dose value found in the border plane is less than 50% of the dose in the central ray plane. The relative maximum of the border plane moves to tissues laying in a greater depth. In case of bi-axial methods, the maximum value of the border plane can be much more than 50% of the maximum dose measured in the central ray plane. (orig.) [de

  3. Galectin-4 and small intestinal brush border enzymes form clusters

    DEFF Research Database (Denmark)

    Danielsen, E M; van Deurs, B

    1997-01-01

    that galectin-4 is indeed an intestinal brush border protein; we also localized galectin-4 throughout the cell, mainly associated with membraneous structures, including small vesicles, and to the rootlets of microvillar actin filaments. This was confirmed by subcellular fractionation, showing about half...... by a nonclassical pathway, and the brush border enzymes represent a novel class of natural ligands for a member of the galectin family. Newly synthesized galectin-4 is rapidly "trapped" by association with intracellular structures prior to its apical secretion, but once externalized, association with brush border......Detergent-insoluble complexes prepared from pig small intestine are highly enriched in several transmembrane brush border enzymes including aminopeptidase N and sucrase-isomaltase, indicating that they reside in a glycolipid-rich environment in vivo. In the present work galectin-4, an animal lectin...

  4. Time to Put the Military on the Border

    National Research Council Canada - National Science Library

    Deforge, Robert D

    2006-01-01

    .... It is well documented that the U.S. Border Patrol is undermanned, under-equipped, and under-trained to deal with the increasing numbers of illegal immigrants, escalating violent gang activity, and in the increasing incidents...

  5. Integrated control of the South African border environment

    CSIR Research Space (South Africa)

    Taute, BJE

    2007-03-01

    Full Text Available flights enter our airspace. To control/coordinate the border environment effectively requires a vast range of information sources, reconnaissance and surveillance sensors, a communications infrastructure and a hub where information can be collected...

  6. Border Security and Military Support: Legal Authorizations and Restrictions

    National Research Council Canada - National Science Library

    Vina, Stephen R

    2006-01-01

    .... Reported escalations in criminal activity and illegal immigration, however, have prompted some law makers to reevaluate the extent and type of military support that occurs in the Mexico-United States border region...

  7. Situational crime prevention and cross-border crime

    NARCIS (Netherlands)

    Kleemans, Edward R.; Soudijn, Melvin R J; Weenink, Anton W.

    2013-01-01

    This chapter explores the consequences of cross-border crime for situational crime prevention. Many types of organised crime involve international smuggling activities – such as drug trafficking, money laundering, smuggling illegal immigrants, and other transnational illegal activities. Based on

  8. Geopolitics in the Forest: A Border of Wilderness

    Czech Academy of Sciences Publication Activity Database

    Grygar, Jakub

    2016-01-01

    Roč. 14, 1/2 (2016), s. 5-23 ISSN 1212-4923 Institutional support: RVO:68378076 Keywords : borders * Białowieża Forest * identity * Europeanization * environmental movement Subject RIV: AC - Archeology, Anthropology, Ethnology

  9. The asymmetry of tourist images for the international cross border ...

    African Journals Online (AJOL)

    The asymmetry of tourist images for the international cross border three- ... of images promotion strategy, which is called “positioning” in Marketing. ... Keywords: tourism, tourist brand, Chita region, Mongolia, tourist and recreational activities ...

  10. Isolated medial meniscal tear in a Border Collie.

    Science.gov (United States)

    Ridge, P A

    2006-01-01

    A three-year-old, female Border Collie was successfully treated for an isolated, torn, medial meniscus by arthroscopic meniscal tear resection. The dog returned to agility competition without recurrence of lameness.

  11. Sharing Residual Liability

    DEFF Research Database (Denmark)

    Carbonara, Emanuela; Guerra, Alice; Parisi, Francesco

    2016-01-01

    Economic models of tort law evaluate the efficiency of liability rules in terms of care and activity levels. A liability regime is optimal when it creates incentives to maximize the value of risky activities net of accident and precaution costs. The allocation of primary and residual liability...... for policy makers and courts in awarding damages in a large number of real-world accident cases....

  12. The Structure of Borders in a Small World

    OpenAIRE

    Thiemann, Christian; Theis, Fabian; Grady, Daniel; Brune, Rafael; Brockmann, Dirk

    2010-01-01

    Territorial subdivisions and geographic borders are essential for understanding phenomena in sociology, political science, history, and economics. They influence the interregional flow of information and cross-border trade and affect the diffusion of innovation and technology. However, it is unclear if existing administrative subdivisions that typically evolved decades ago still reflect the most plausible organizational structure of today. The complexity of modern human communication, the eas...

  13. Transboundary data management for nuclear plants near national borders

    International Nuclear Information System (INIS)

    Narrog, J.; Obrecht, R.

    1998-01-01

    Transboundary data management was decided in the EU in case of incidents and accidents. The information is sent by codified messages in accordance with the Convention Information Structure (CIS). Within the international collaboration regarding nuclear installations near national borders, fixed telephone and tele-copy connections are used. In addition to that an online data exchange between France and Germany is being installed. This facilitates and accelerates ascertaining the radiological situation for both partners across the national borders. (author)

  14. The SPS was the second cross-border accelerator

    CERN Multimedia

    2004-01-01

    In the Golden Jubilee article in the issue 25/2004 (14 June) we should have written that the SPS was the first big cross-border accelerator. In fact, the SPS was not the first cross-border accelerator: that title goes to the PS Booster which became operational in 1972. The PS Booster passes beams to the PS and to the ISOLDE facility. We are sorry for the mistake and thank our vigilant readers.

  15. Border Biofuels Limited - maintaining a sense of balance

    International Nuclear Information System (INIS)

    Seed, J.M.

    1994-01-01

    A brief description is given of a renewable energy initiative to grow wood fuel in the Scottish and English border region. The aim is to develop a new rural industry based on wood fuel feeding a power plant in a central location in the Borders area. The financial arrangements to grow short rotation coppice are outlined as are the environmental impacts and energy balance. (UK)

  16. Using automatic identification system technology to improve maritime border security

    OpenAIRE

    Lindstrom, Tedric R.

    2014-01-01

    Approved for public release; distribution is unlimited Our coastal waters are the United States’ most open and vulnerable borders. This vast maritime domain harbors critical threats from terrorism, criminal activities, and natural disasters. Maritime borders pose significant security challenges, as nefarious entities have used small boats to conduct illegal activities for years, and they continue to do so today. Illegal drugs, money, weapons, and migrants flow both directions across our ma...

  17.   Border Carbon Adjustments, the UNFCCC and WTO Rules

    DEFF Research Database (Denmark)

    Nielsen, Laura

    2010-01-01

      My presentation on Trade and Climate Change concludes that border carbon adjustments can be consistent with both the climate change and WTO rules - depending of course on their design - but that they are not necessarily attractive. ......  My presentation on Trade and Climate Change concludes that border carbon adjustments can be consistent with both the climate change and WTO rules - depending of course on their design - but that they are not necessarily attractive. ...

  18. The financial implications of certain types of cross-border pollution: The polluter-pays principle

    International Nuclear Information System (INIS)

    Montmayeul, J.P.

    2001-01-01

    Favorable Paris Convention regulations: absolute liability, exclusive liability, channeling of liability to the operator in case of nuclear damage, financial security, limited maximum liability, single legal forum, ten-year time limit. Difficulties of application for certain types of cross-border pollution not covered by the Paris Convention: so-called orphan sources (stolen, lost, or abandoned sealed sources or confiscated contaminated metallurgical scrap). Benefits of the polluter-pays principle: identification of the polluter, identification of the holder of the polluted materials, responsible parties held accountable, financial reparations. Analysis of the polluter-pays principle already recognized in numerous international texts on environmental law. (author)

  19. Abortion checks at German-Dutch border.

    Science.gov (United States)

    Von Baross, J

    1991-05-01

    The commentary on West German abortion law, particularly in illegal abortion in the Netherlands, finds the law restrictive and in violation of the dignity and rights of women. The Max-Planck Institute in 1990 published a study that found that a main point of prosecution between 1976 and 1986, as reported by Der Spiegal, was in border crossings from the Netherlands. It is estimated that 10,000 annually have abortions abroad, and 6,000 to 7,000 in the Netherlands. The procedure was for an official to stop a young person and query about drugs; later the woman would admit to an abortion, and be forced into a medical examination. The German Penal Code Section 218 stipulates abortion only for certain reasons testified to by a doctor other than the one performing the abortion. Counseling on available social assistance must be completed 3 days prior to the abortion. Many counseling offices are church related and opposed to abortions. Many doctors refuse legally to certify, and access to abortion is limited. The required hospital stay is 3-4 nights with no day care facilities. Penal Code Section 5 No. 9 allows prosecution for uncounseled illegal abortion. Abortion law reform is anticipated by the end of 1992 in the Bundestag due to the Treaty or the Unification of Germany. The Treaty states that the rights of the unborn child must be protected and that pregnant women relieve their distress in a way compatible with the Constitution, but improved over legal regulations from either West or East Germany, which permits abortion on request within 12 weeks of conception without counseling. It is hoped that the law will be liberalized and Penal Code Section 5 No. 9 will be abolished.

  20. The Treaty of Lisbon and the European Border Control Regime

    Directory of Open Access Journals (Sweden)

    Marianne Takle

    2012-08-01

    Full Text Available The question raised in the article is how the new provisions of the Lisbon Treaty and the Stockholm programme concerning the EU’s asylum and migration policy might consolidate existing trends within the European border control regime. The regime is defined by a combination of three features: (i a harmonisation of categories among the EU/Schengen member states, (ii a growing use of new technology in networked databases and (iii an increasing sorting of individuals based on security concerns. Although none of these features is new, the combination gives a new impetus to the European border control regime. The article concludes that the Lisbon Treaty and the Stockholm programme consolidate and strengthen existing trends. This implies that policies on border control, asylum, immigration, judicial cooperation and police cooperation are consolidated in a broader approach to border control, and that there is a strengthening of EU foreign policy within the European border control regime. The boundaries between previously dispersed policy areas are blurred. The combination of different aspects of security and various levels of authority requires coordination of policies with substantially different goals, and goes beyond mere border control.

  1. A soft kinetic data structure for lesion border detection.

    Science.gov (United States)

    Kockara, Sinan; Mete, Mutlu; Yip, Vincent; Lee, Brendan; Aydin, Kemal

    2010-06-15

    The medical imaging and image processing techniques, ranging from microscopic to macroscopic, has become one of the main components of diagnostic procedures to assist dermatologists in their medical decision-making processes. Computer-aided segmentation and border detection on dermoscopic images is one of the core components of diagnostic procedures and therapeutic interventions for skin cancer. Automated assessment tools for dermoscopic images have become an important research field mainly because of inter- and intra-observer variations in human interpretations. In this study, a novel approach-graph spanner-for automatic border detection in dermoscopic images is proposed. In this approach, a proximity graph representation of dermoscopic images in order to detect regions and borders in skin lesion is presented. Graph spanner approach is examined on a set of 100 dermoscopic images whose manually drawn borders by a dermatologist are used as the ground truth. Error rates, false positives and false negatives along with true positives and true negatives are quantified by digitally comparing results with manually determined borders from a dermatologist. The results show that the highest precision and recall rates obtained to determine lesion boundaries are 100%. However, accuracy of assessment averages out at 97.72% and borders errors' mean is 2.28% for whole dataset.

  2. Mapping and assessing the environmental impacts of border tactical infrastructure in the Sky Island Region

    Science.gov (United States)

    Caroline Patrick-Birdwell; Sergio Avila-Villegas; Jenny Neeley; Louise Misztal

    2013-01-01

    In this project we mapped the different types of border barriers, identified impacts of border infrastructure on public and private lands and conducted spatial analyses within the approximately 200 miles of international border in the Sky Island region. The Sky Island region, bisected by the U.S.-Mexico border, is critically important for its biodiversity and...

  3. 78 FR 35103 - Extension of Border Zone in the State of New Mexico

    Science.gov (United States)

    2013-06-12

    ..., established in 1953, was intended to promote the economic stability of the border region by allowing for freer... having to obtain a Form I-94. Although the border zone was intended to promote the economic stability of... maintain security of the border while increasing economic activity in New Mexico's border region and...

  4. Effect of the US-Mexico border region in cardiovascular mortality: ecological time trend analysis of Mexican border and non-border municipalities from 1998 to 2012

    Directory of Open Access Journals (Sweden)

    Gabriel Anaya

    2017-05-01

    Full Text Available Abstract Background An array of risk factors has been associated with cardiovascular diseases, and developing nations are becoming disproportionately affected by such diseases. Cardiovascular diseases have been reported to be highly prevalent in the Mexican population, but local mortality data is poor. The Mexican side of the US-Mexico border has a culture that is closely related to a developed nation and therefore may share the same risk factors of cardiovascular diseases. We wanted to explore if there was higher cardiovascular mortality in the border region of Mexico compared to the rest of the nation. Methods We conducted a population based cross-sectional time series analysis to estimate the effects of education, insurance and municipal size in Mexican border (n = 38 and non-border municipalities (n = 2360 and its association with cardiovascular age-adjusted mortality rates between the years 1998–2012. We used a mixed effect linear model with random effect estimation and repeated measurements to compare the main outcome variable (mortality rate, the covariates (education, insurance and population size and the geographic delimiter (border/non-border. Results Mortality due to cardiovascular disease was consistently higher in the municipalities along the US-Mexico border, showing a difference of 78 · 5 (95% CI 58 · 7-98 · 3, p < 0 · 001 more cardiovascular deaths after adjusting for covariates. Larger municipal size and higher education levels showed a reduction in cardiovascular mortality of 12 · 6 (95% CI 11 · 4-13 · 8, p < 0 · 001 deaths and 8 · 6 (95% CI 5 · 5-11 · 8, p < 0 · 001 deaths respectively. Insurance coverage showed an increase in cardiovascular mortality of 3 · 6 (95% CI 3 · 1-4 · 0, p < 0 · 001 deaths per decile point increase. There was an increase in cardiovascular mortality of 0 · 3 (95% CI −0 · 001-0 · 6

  5. Machine for compacting solid residues

    International Nuclear Information System (INIS)

    Herzog, J.

    1981-11-01

    Machine for compacting solid residues, particularly bulky radioactive residues, constituted of a horizontally actuated punch and a fixed compression anvil, in which the residues are first compacted horizontally and then vertically. Its salient characteristic is that the punch and the compression anvil have embossments on the compression side and interpenetrating plates in the compression position [fr

  6. Quadratic residues and non-residues selected topics

    CERN Document Server

    Wright, Steve

    2016-01-01

    This book offers an account of the classical theory of quadratic residues and non-residues with the goal of using that theory as a lens through which to view the development of some of the fundamental methods employed in modern elementary, algebraic, and analytic number theory. The first three chapters present some basic facts and the history of quadratic residues and non-residues and discuss various proofs of the Law of Quadratic Reciprosity in depth, with an emphasis on the six proofs that Gauss published. The remaining seven chapters explore some interesting applications of the Law of Quadratic Reciprocity, prove some results concerning the distribution and arithmetic structure of quadratic residues and non-residues, provide a detailed proof of Dirichlet’s Class-Number Formula, and discuss the question of whether quadratic residues are randomly distributed. The text is a valuable resource for graduate and advanced undergraduate students as well as for mathematicians interested in number theory.

  7. Insecticide residues in stored grains in Sonora, Mexico: quantification and toxicity testing.

    Science.gov (United States)

    Aldana-Madrid, M L; Valdez-Hurtado, S; Vargas-Valdez, N D; Salazar-Lopez, N J; Silveira-Gramont, M I; Loarca-Piña, F G; Rodríguez-Olibarria, G; Wong-Corral, F J; Borboa-Flores, J; Burgos-Hernández, A

    2008-02-01

    Food safety has acquired great attention by food importer and exporters. Food rejection or acceptance across international borders is based on the compliance with international food regulations. Due to the lack of recent data on pesticide residues in Mexican grains, this study focused on detecting and quantifying insecticide residues in stored wheat, corn, chickpeas, and beans, as well as to determine their mutagenic potential. Grains were sampled from primary storage sites in Sonora, Mexico. Malathion, chlorpyrifos, deltamethrin, cypermethrin, 4,4-DDE, 4,4-DDD and 4,4-DDT were analyzed in 135 samples. Grain samples were not mutagenic and most pesticide levels were within regulation limits.

  8. Food security in a world without borders.

    Science.gov (United States)

    de Haen, Hartwig; Thompson, Brian

    2003-01-01

    is through community nutrition programmes that encourage the full participation and co-operation of the entire community, maximise the utilisation of local resources, grasp the benefits of new technologies for productivity gains, involve multiple sectors and engage strong political commitment. The international community will be judged by its treatment of its most vulnerable members. The international community has repeatedly declared that it is dedicated to the eradication of poverty. Eliminating hunger and malnutrition is a vital first step. The political will to fight hunger and a firm commitment to invest in agriculture' and rural development are critical elements in any effort to achieve sustainable alleviation of hunger and poverty. This meeting and the WFS:FYL provide the additional impetus to meet the challenge of achieving food and nutritional security in a world without borders and free from hunger and malnutrition.

  9. A neural model of border-ownership from kinetic occlusion.

    Science.gov (United States)

    Layton, Oliver W; Yazdanbakhsh, Arash

    2015-01-01

    Camouflaged animals that have very similar textures to their surroundings are difficult to detect when stationary. However, when an animal moves, humans readily see a figure at a different depth than the background. How do humans perceive a figure breaking camouflage, even though the texture of the figure and its background may be statistically identical in luminance? We present a model that demonstrates how the primate visual system performs figure-ground segregation in extreme cases of breaking camouflage based on motion alone. Border-ownership signals develop as an emergent property in model V2 units whose receptive fields are nearby kinetically defined borders that separate the figure and background. Model simulations support border-ownership as a general mechanism by which the visual system performs figure-ground segregation, despite whether figure-ground boundaries are defined by luminance or motion contrast. The gradient of motion- and luminance-related border-ownership signals explains the perceived depth ordering of the foreground and background surfaces. Our model predicts that V2 neurons, which are sensitive to kinetic edges, are selective to border-ownership (magnocellular B cells). A distinct population of model V2 neurons is selective to border-ownership in figures defined by luminance contrast (parvocellular B cells). B cells in model V2 receive feedback from neurons in V4 and MT with larger receptive fields to bias border-ownership signals toward the figure. We predict that neurons in V4 and MT sensitive to kinetically defined figures play a crucial role in determining whether the foreground surface accretes, deletes, or produces a shearing motion with respect to the background. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. Protein secondary structure prediction for a single-sequence using hidden semi-Markov models

    Directory of Open Access Journals (Sweden)

    Borodovsky Mark

    2006-03-01

    Full Text Available Abstract Background The accuracy of protein secondary structure prediction has been improving steadily towards the 88% estimated theoretical limit. There are two types of prediction algorithms: Single-sequence prediction algorithms imply that information about other (homologous proteins is not available, while algorithms of the second type imply that information about homologous proteins is available, and use it intensively. The single-sequence algorithms could make an important contribution to studies of proteins with no detected homologs, however the accuracy of protein secondary structure prediction from a single-sequence is not as high as when the additional evolutionary information is present. Results In this paper, we further refine and extend the hidden semi-Markov model (HSMM initially considered in the BSPSS algorithm. We introduce an improved residue dependency model by considering the patterns of statistically significant amino acid correlation at structural segment borders. We also derive models that specialize on different sections of the dependency structure and incorporate them into HSMM. In addition, we implement an iterative training method to refine estimates of HSMM parameters. The three-state-per-residue accuracy and other accuracy measures of the new method, IPSSP, are shown to be comparable or better than ones for BSPSS as well as for PSIPRED, tested under the single-sequence condition. Conclusions We have shown that new dependency models and training methods bring further improvements to single-sequence protein secondary structure prediction. The results are obtained under cross-validation conditions using a dataset with no pair of sequences having significant sequence similarity. As new sequences are added to the database it is possible to augment the dependency structure and obtain even higher accuracy. Current and future advances should contribute to the improvement of function prediction for orphan proteins inscrutable

  11. Bending the law and crossing borders

    DEFF Research Database (Denmark)

    Willum Adrian, Stine

    In recent years, Denmark has become a European destination for sperm donation. One reason is that the current regulation on both private sperm banking and donor insemination is liberal, compared to neighboring countries. The Danish legislation enables both single women, lesbians and heterosexual...

  12. Bioenergy from sisal residues

    Energy Technology Data Exchange (ETDEWEB)

    Jungersen, G. [Dansk Teknologisk Inst. (Denmark); Kivaisi, A.; Rubindamayugi, M. [Univ. of Dar es Salaam (Tanzania, United Republic of)

    1998-05-01

    The main objectives of this report are: To analyse the bioenergy potential of the Tanzanian agro-industries, with special emphasis on the Sisal industry, the largest producer of agro-industrial residues in Tanzania; and to upgrade the human capacity and research potential of the Applied Microbiology Unit at the University of Dar es Salaam, in order to ensure a scientific and technological support for future operation and implementation of biogas facilities and anaerobic water treatment systems. The experimental work on sisal residues contains the following issues: Optimal reactor set-up and performance; Pre-treatment methods for treatment of fibre fraction in order to increase the methane yield; Evaluation of the requirement for nutrient addition; Evaluation of the potential for bioethanol production from sisal bulbs. The processing of sisal leaves into dry fibres (decortication) has traditionally been done by the wet processing method, which consumes considerable quantities of water and produces large quantities of waste water. The Tanzania Sisal Authority (TSA) is now developing a dry decortication method, which consumes less water and produces a waste product with 12-15% TS, which is feasible for treatment in CSTR systems (Continously Stirred Tank Reactors). (EG)

  13. Public health and terrorism preparedness: cross-border issues.

    Science.gov (United States)

    Olson, Debra; Leitheiser, Aggie; Atchison, Christopher; Larson, Susan; Homzik, Cassandra

    2005-01-01

    On December 15, 2003, the Centers for Public Health Preparedness at the University of Minnesota and the University of Iowa convened the "Public Health and Terrorism Preparedness: Cross-Border Issues Roundtable." The purpose of the roundtable was to gather public health professionals and government agency representatives at the state, provincial, and local levels to identify unmet cross-border emergency preparedness and response needs and develop strategies for addressing these needs. Representatives from six state and local public health departments and three provincial governments were invited to identify cross-border needs and issues using a nominal group process. The result of the roundtable was identification of the needs considered most important and most doable across all the focus groups. The need to collaborate on and exchange plans and protocols among agencies was identified as most important and most doable across all groups. Development of contact protocols and creation and maintenance of a contact database was also considered important and doable for a majority of groups. Other needs ranked important across the majority of groups included specific isolation and quarantine protocols for multi-state responses; a system for rapid and secure exchange of information; specific protocols for sharing human resources across borders, including emergency credentials for physicians and health care workers; and a specific protocol to coordinate Strategic National Stockpile mechanisms across border communities.

  14. Art and cartography as a critique of borders

    Science.gov (United States)

    Melo Ribeiro, Daniel

    2018-05-01

    This study focuses on the relationship between art and cartography. The main objective is to analyze how contemporary art uses maps to criticize borders. Inspired by the arguments raised by the Critical Cartography against the false neutrality of maps, we emphasize the potential of artworks to communicate different insights about how we experience and live the contemporary space. In that sense, art plays an important role not only to discuss the articulation of power and knowledge in cartography, but also to propose other categories of thought. Considering that borders are one of the most relevant visual elements on a map, we propose the following question: how the intersection between art and cartography can improve the critical thinking about borders? By questioning borders, art underlines that physical world is characterized by liminal spaces, not by absolute or strict separations. We briefly analyzed some examples of artworks that deal with political issues regarding this topic. Our findings suggest that art could reveal the impact of imposing borders in a space, whose arbitrary delimitation reflects power relations.

  15. Being thought from beyond our borders: Towards ethical global citizenship

    Directory of Open Access Journals (Sweden)

    Johann-Albrecht Meylahn

    2009-09-01

    Full Text Available This article is a response to the challenge of global citizenship in an age of global crisis. Citizenship has to do with where one feels �at home�, namely the space that gifts identity and life. What kind of narrative is necessary to transform global space into a home from where we can go beyond our borders to embrace the other in multidisciplinary research or interfaith praxis? The different models for multidisciplinary research are made possible by the idea that research seeks that which is beyond its borders. This search could be a common space where the different traditions can accommodate one another, but it is not a home. The dominant discourse of this common space is to seek commonality and identities across borders while being aware of but ignoring differences � identity at the expense of differences. A home founded on identity at the expense of difference will always exclude. Theology can either be interpreted as thinking beyond the borders toward the Divine, or the Divine thinking us. The Exodus, the Incarnation and the Cross are all narratives of the Other crossing borders, liberating from boundaries, deconstructing the laws and norms that exclude. The religious traditions of these sacred narratives have something to offer, namely: to be thought by the Other, to receive life and (alien identity from the Other, the gift of a home which is continuously deconstructed by the home still to come, therefore always open for the Other.

  16. The role of immigration age on alcohol and drug use among border and non-border Mexican Americans.

    Science.gov (United States)

    Reingle, Jennifer M; Caetano, Raul; Mills, Britain A; Vaeth, Patrice A C

    2014-07-01

    To determine the age of immigration at which the marked increase in risk for alcohol- and drug-use problems in adulthood is observed among Mexican American adults residing in 2 distinct contexts: the U.S.-Mexico border, and cities not proximal to the border. We used 2 samples of Mexican American adults: specifically, 1,307 who resided along the U.S.-Mexico border, and 1,288 non-border adults who were interviewed as a part of the 2006 Hispanic Americans Baseline Alcohol Survey study. Survey logistic and Poisson regression methods were used to examine how immigration age during adolescence is related to alcohol- and drug-use behavior in adulthood. We found that participants who immigrate to the United States prior to age 14 have qualitatively different alcohol- and drug-related outcomes compared to those who immigrate later in life. Adults who immigrated at younger ages have alcohol- and drug-use patterns similar to those who were U.S.-born. Adults who immigrated at young ages and reside distal from the U.S.-Mexico border are at greater risk for alcohol and drug use than those who live in border contexts. Immigration from Mexico to the U.S. before age 14 results in alcohol- and drug-related behavior that mirrors the behavior of U.S.-born residents, and the alcohol- and drug-use effects were more pronounced among adults who did not reside proximal to the U.S.-Mexico border. Copyright © 2014 by the Research Society on Alcoholism.

  17. Analysis of the highly diverse gene borders in Ebola virus reveals a distinct mechanism of transcriptional regulation.

    Science.gov (United States)

    Brauburger, Kristina; Boehmann, Yannik; Tsuda, Yoshimi; Hoenen, Thomas; Olejnik, Judith; Schümann, Michael; Ebihara, Hideki; Mühlberger, Elke

    2014-11-01

    Ebola virus (EBOV) belongs to the group of nonsegmented negative-sense RNA viruses. The seven EBOV genes are separated by variable gene borders, including short (4- or 5-nucleotide) intergenic regions (IRs), a single long (144-nucleotide) IR, and gene overlaps, where the neighboring gene end and start signals share five conserved nucleotides. The unique structure of the gene overlaps and the presence of a single long IR are conserved among all filoviruses. Here, we sought to determine the impact of the EBOV gene borders during viral transcription. We show that readthrough mRNA synthesis occurs in EBOV-infected cells irrespective of the structure of the gene border, indicating that the gene overlaps do not promote recognition of the gene end signal. However, two consecutive gene end signals at the VP24 gene might improve termination at the VP24-L gene border, ensuring efficient L gene expression. We further demonstrate that the long IR is not essential for but regulates transcription reinitiation in a length-dependent but sequence-independent manner. Mutational analysis of bicistronic minigenomes and recombinant EBOVs showed no direct correlation between IR length and reinitiation rates but demonstrated that specific IR lengths not found naturally in filoviruses profoundly inhibit downstream gene expression. Intriguingly, although truncation of the 144-nucleotide-long IR to 5 nucleotides did not substantially affect EBOV transcription, it led to a significant reduction of viral growth. Our current understanding of EBOV transcription regulation is limited due to the requirement for high-containment conditions to study this highly pathogenic virus. EBOV is thought to share many mechanistic features with well-analyzed prototype nonsegmented negative-sense RNA viruses. A single polymerase entry site at the 3' end of the genome determines that transcription of the genes is mainly controlled by gene order and cis-acting signals found at the gene borders. Here, we examined

  18. Geochemical Testing And Model Development - Residual Tank Waste Test Plan

    International Nuclear Information System (INIS)

    Cantrell, K.J.; Connelly, M.P.

    2010-01-01

    This Test Plan describes the testing and chemical analyses release rate studies on tank residual samples collected following the retrieval of waste from the tank. This work will provide the data required to develop a contaminant release model for the tank residuals from both sludge and salt cake single-shell tanks. The data are intended for use in the long-term performance assessment and conceptual model development.

  19. Process for measuring residual stresses

    International Nuclear Information System (INIS)

    Elfinger, F.X.; Peiter, A.; Theiner, W.A.; Stuecker, E.

    1982-01-01

    No single process can at present solve all problems. The complete destructive processes only have a limited field of application, as the component cannot be reused. However, they are essential for the basic determination of stress distributions in the field of research and development. Destructive and non-destructive processes are mainly used if investigations have to be carried out on original components. With increasing component size, the part of destructive tests becomes smaller. The main applications are: quality assurance, testing of manufactured parts and characteristics of components. Among the non-destructive test procedures, X-raying has been developed most. It gives residual stresses on the surface and on surface layers near the edges. Further development is desirable - in assessment - in measuring techniques. Ultrasonic and magnetic crack detection processes are at present mainly used in research and development, and also in quality assurance. Because of the variable depth of penetration and the possibility of automation they are gaining in importance. (orig./RW) [de

  20. State borders in ETRS89 coordinates – reality or fiction ?

    Directory of Open Access Journals (Sweden)

    Jiří Poláček

    2015-12-01

    Full Text Available Common unique ETRS89 coordinates of the state boundaries are crucial for cross-border data harmonization for international projects. In the frame of European Location Framework (ELF project Czech Office for Surveying, Mapping and Cadastre (ČÚZK cooperates with Poland on egde-matching on the state border. During the preliminary phase of the project was some difficulty identified. If the state boundary is measured and administered in the national coordinate system, the accuracy of the transformation into the ETRS89 is influenced by discrepancies of the local trigonometric network, which results in two slightly different state boundaries. Final solution for Europe – international treaties on the state borders based on the ETRS89 coordinates – is necessary, but it will take years.

  1. Tracing of border trap behavior by noise analysis in microelectronics

    International Nuclear Information System (INIS)

    Sharshar, K.A.A.; Shaalan, A.A.M.; Gomaa, E.I.

    2008-01-01

    The present state of art of this work is to study the electrical defects of the silicon- silicon dioxide interface created by gamma rays (Co 60 ) in submicron MOS devices used in telecommunication systems. We focus our investigation on a particular class of trapped charge located near the interface characterized as the border traps. The expected physical location and chemical structure of the traps were discussed. The low frequency 1/f noise measurement is used in the estimation of border trap densities before and after irradiation; the results are reported for n-MOS transistor exposed to doses (0.3, 0.5, 1 and 10 Mrad). The border trap population in the irradiated samples increased from 7.6*10 10 up to 1.03*10 11 eV -1 Cm -2

  2. Border-ownership-dependent tilt aftereffect in incomplete figures

    Science.gov (United States)

    Sugihara, Tadashi; Tsuji, Yoshihisa; Sakai, Ko

    2007-01-01

    A recent physiological finding of neural coding for border ownership (BO) that defines the direction of a figure with respect to the border has provided a possible basis for figure-ground segregation. To explore the underlying neural mechanisms of BO, we investigated stimulus configurations that activate BO circuitry through psychophysical investigation of the BO-dependent tilt aftereffect (BO-TAE). Specifically, we examined robustness of the border ownership signal by determining whether the BO-TAE is observed when gestalt factors are broken. The results showed significant BO-TAEs even when a global shape was not explicitly given due to the ambiguity of the contour, suggesting a contour-independent mechanism for BO coding.

  3. Forecasting the electricity consumption of the Mexican border states maquiladoras

    Energy Technology Data Exchange (ETDEWEB)

    Flores, C.E.; Phelan, P.E. [Arizona State Univ., Dept. of Mechanical and Aerospace Engineering, Tempe, AZ (United States); Mou, J.-I. [Taiwan Semiconductor Manufacturing Co., Operation Planning Div., Hsin-Chu (Taiwan); Bryan, H. [Arizona State Univ., School of Architecture, Tempe, AZ (United States)

    2004-07-01

    The consumption of electricity by maquiladora industries in the Mexican border states is an important driver for determining future powerplant needs in that area. An industrial electricity forecasting model is developed for the border states' maquiladoras, and the outputs are compared with a reference forecasting model developed for the US industrial sector, for which considerably more data are available. This model enables the prediction of the effect of implementing various energy efficiency measures in the industrial sector. As an illustration, here the impact of implementing energy-efficient lighting and motors in the Mexican border states' maquiladoras was determined to be substantial. Without such energy efficiency measures, electricity consumption for these industries is predicted to rise by 64% from 2001 to 2010, but if these measures are implemented on a gradual basis over the same time period, electricity consumption is forecast to rise by only 36%. (Author)

  4. MATRIX FOR COOPERATION IN THE CROSS-BORDER AREAS

    Directory of Open Access Journals (Sweden)

    Marcela ȘLUSARCIUC

    2014-06-01

    Full Text Available The crossborder areas have no constitutional competences, therefore most of the times they are not part of the decision making process in the agreements in cross-border relationships. Although the states are the ones to decide the policies and the agreements based on their own legal rules, considering the shape of the new European Union, they should more and more accept the conditionality of a regional overstate structure linked only to some geographical parts of the countries. The present paper proposes a theoretical and intuitive frame for assessing the cross-border areas based on the factors that are influencing it, starting from a listing of them, secondly grouping them in separating and uniting, then finding the significant differences. The matrix of factors can be used for conflict resolution or for development of cross-border areas as long as it shows the points that will be a potential obstacle or a source for cooperation.

  5. Displaced Borders: The Written Traumatic Borderline between Pskov Province and Chechnya

    Directory of Open Access Journals (Sweden)

    Mari Ristolainen

    2014-12-01

    Full Text Available This article examines the narrative construction of borders through an analysis of "non-professional writing" produced by the residents of Pskov. It discusses the construction of national borders and the symbolic meanings invested in them, with the empirical focus being placed on the symbolic Russian-Chechen border. The theoretical essence is the realization that due to the constructive and narrative na-tures of border production, the creation of a national borderline does not necessarily pre-suppose that the two sides share a geographical border. The article also addresses questions of traumatic memory and links border production with the concept of cultural trauma. By asking where Russia's borders currently located, this article provides an example of the cultural construction and symbolic displacement of the "national border", and a representation of how the national b/ordering processes differ when viewed from both "bottom up" and "top-down" perspectives in the contemporary Russian Federation.

  6. Factors Associated with Depression Among Mexican Americans Living in U.S.-Mexico Border and Non-Border Areas.

    Science.gov (United States)

    Vaeth, Patrice A C; Caetano, Raul; Mills, Britain A

    2016-08-01

    Factors associated with CES-D depression among Mexican Americans living on and off the U.S.-Mexico border are examined. Data are from two studies of Mexican American adults. The Border Survey conducted face-to-face interviews in urban U.S.-Mexico border counties of California, Arizona, New Mexico, and Texas (N = 1307). The non-border HABLAS survey conducted face-to-face interviews in Houston, Los Angeles, New York, Philadelphia, and Miami (N = 1288). Both surveys used a multistage cluster sample design with response rates of 67 and 76 %, respectively. The multivariate analysis showed that border residence and higher perceived neighborhood collective efficacy were protective for depression among men. Among men, lower education, unemployment, increased weekly drinking, and poor health status were associated with depression. Among women, alcohol-related problems and poorer health status were also associated with depression. Further examinations of how neighborhood perceptions vary by gender and how these perceptions influence the likelihood of depression are warranted.

  7. [Transnational solidarity? Cross-border heath-care in the European Union].

    Science.gov (United States)

    Schmucker, R

    2010-03-01

    The responsibilities of the European Union surrounding public health are concentrated on co-ordinating and complementary practices. A mandatory European harmonization of standards and policies is in effect in only a few areas such as pharmaceutical authorization and health protection at the workplace. The implementation of single market rights over the national health-care systems (negative integration) is growing at the European level. This has ambivalent repercussions. Whilst the rights of patients on the basis of the four fundamental freedoms in the context of cross-border health-care have got stronger, national governments see themselves confronted with a limitation of scope for their health-care policies. The basic principles of the integration project place European pressure on national governments. They are subject to sanctions if their policies are not directly in accordance with the single market concept. Georg Thieme Verlag KG Stuttgart. New York.

  8. Conception of integrator in cross-border E-commerce

    Directory of Open Access Journals (Sweden)

    Arkadiusz Kawa

    2016-03-01

    Full Text Available Background:  E-commerce is one of the most dynamic and important sectors of the economy. The latest trend in this market is cross-border trade. It is based on selling products to customers who are located in other countries. However, it is connected to several problems, such as a high cost and long time of delivery, language barriers, different legal and tax conditionings, etc. Methods: The studies were conducted on the basis of the authors' experience in the field of e-commerce. The issue of cross-border commerce was mainly analysed with the use of reports of the European Commission. The aim of the article is to propose a conception of an integrator of cross-border e-commerce, which will make it possible, among other things, to solve logistic problems. Results: The article presents an authorial conception of an integrator in cross-border e-commerce. Its main task is to integrate the whole supply chain. Thanks to the economies of scale, obtained as a result of consolidation of parcels from many e-shops, the integrator is able to achieve lower delivery costs in international transport, make returns of goods more effective and serve customers from different countries better. Conclusions: The conception of an integrator in cross-border commerce proposed in the article may increase competitiveness of micro and small e-enterprises, especially in the international arena. Moreover, applying this conception may contribute to a rise in the attractiveness of cross-border commerce, which, as result of a greater sale level, would contribute to an increase in the total e-commerce.

  9. Information Analysis Methodology for Border Security Deployment Prioritization and Post Deployment Evaluation

    International Nuclear Information System (INIS)

    Booker, Paul M.; Maple, Scott A.

    2010-01-01

    Due to international commerce, cross-border conflicts, and corruption, a holistic, information driven, approach to border security is required to best understand how resources should be applied to affect sustainable improvements in border security. The ability to transport goods and people by land, sea, and air across international borders with relative ease for legitimate commercial purposes creates a challenging environment to detect illicit smuggling activities that destabilize national level border security. Smuggling activities operated for profit or smuggling operations driven by cross border conflicts where militant or terrorist organizations facilitate the transport of materials and or extremists to advance a cause add complexity to smuggling interdiction efforts. Border security efforts are further hampered when corruption thwarts interdiction efforts or reduces the effectiveness of technology deployed to enhance border security. These issues necessitate the implementation of a holistic approach to border security that leverages all available data. Large amounts of information found in hundreds of thousands of documents can be compiled to assess national or regional borders to identify variables that influence border security. Location data associated with border topics of interest may be extracted and plotted to better characterize the current border security environment for a given country or region. This baseline assessment enables further analysis, but also documents the initial state of border security that can be used to evaluate progress after border security improvements are made. Then, border security threats are prioritized via a systems analysis approach. Mitigation factors to address risks can be developed and evaluated against inhibiting factor such as corruption. This holistic approach to border security helps address the dynamic smuggling interdiction environment where illicit activities divert to a new location that provides less resistance

  10. Fuel tourism in border regions: The case of Switzerland

    International Nuclear Information System (INIS)

    Banfi, S.; Filippini, M.; Universita della Svizzera italiana, Lugano; Hunt, L.C.

    2005-01-01

    This paper explores the issue of 'fuel tourism' in Switzerland. For the period 1985-1997, a panel data model for the border regions of Switzerland, (Italy, France, and Germany) is estimated. The results show a significant impact of the gasoline price differential on demand, suggesting that a decrease of 10% in the Swiss gasoline price leads to an increase in demand in the border areas of nearly 17.5%. It is shown that fuel tourism accounted for about 9% of overall gasoline sales in the three regions during the period 1985-1997 and that the recently proposed Swiss CO 2 -tax might, given current conditions, eliminate net fuel tourism. (author)

  11. Cross-border mergers and acquisitions and European integration

    OpenAIRE

    Coeurdacier, Nicolas; de Santis, Roberto A.; Aviat, Antonin

    2009-01-01

    Cross-border mergers and acquisitions activities (M&As) sharply increased over the last two decades, partly as a result of financial liberalization policies, government policies and regional agreements. In this paper, we identify some of the main forces driving M&As, using a unique database on bilateral cross-border M&As at the sectoral level (in manufacturing and services) over the period 1985-2004. The key empirical findings are: (1) EMU helped the restructuring of capital within the same s...

  12. Border collisions inside the stability domain of a fixed point

    DEFF Research Database (Denmark)

    Avrutin, Viktor; Zhusubaliyev, Zhanybai T.; Mosekilde, Erik

    2016-01-01

    a complicated interior structure formed by boundaries defined by persistence border collisions. We describe a simple approach that is based on symbolic dynamics and makes it possible to detect such boundaries numerically. Using this approach we describe several regions in the parameter space leading......Recent studies on a power electronic DC/AC converter (inverter) have demonstrated that such systems may undergo a transition from regular dynamics (associated with a globally attracting fixed point of a suitable stroboscopic map) to chaos through an irregular sequence of border-collision events...

  13. Surface reconstruction, figure-ground modulation, and border-ownership.

    Science.gov (United States)

    Jeurissen, Danique; Self, Matthew W; Roelfsema, Pieter R

    2013-01-01

    The Differentiation-Integration for Surface Completion (DISC) model aims to explain the reconstruction of visual surfaces. We find the model a valuable contribution to our understanding of figure-ground organization. We point out that, next to border-ownership, neurons in visual cortex code whether surface elements belong to a figure or the background and that this is influenced by attention. We furthermore suggest that there must be strong links between object recognition and figure-ground assignment in order to resolve the status of interior contours. Incorporation of these factors in neurocomputational models will further improve our understanding of surface reconstruction, figure-ground organization, and border-ownership.

  14. Brujeria and the U.S.-Mexico Border Outlaw

    Directory of Open Access Journals (Sweden)

    Rachel Conover

    2007-12-01

    Full Text Available This paper investigates the death metal band Brujeria, their use of both traditional and contemporary outlaw imagery, and their connection to the narcocorrido, in order to examine the tenacity of the outlaw paradigm as an expression of resistance by subordinate groups in situations of social inequality. It deals with the contemporary figure of the outlaw in connection to the U.S.-Mexico border region, as influenced by outlaw traditions in the area, and as an expression of specific contemporary historical circumstances of that region, including Mexican economic crisis, globalization, and border conflicts surrounding immigration, drug trafficking, and labor.

  15. A Philosophical vs. a Psychological Perspective on Borders.

    Science.gov (United States)

    Klempe, Sven Hroar

    2016-03-01

    This paper questions to what extent borders are to be understood from a philosophical or a psychological perspective. This is done by investigating the distinction between philosophy and psychology that comes up as a result of Immanuel Kant's investigation of the pure reason. Ontology is found as a demarcation criterion between the two fields in the sense that it is of crucial importance in philosophy, but not of certain interest from a psychological point of view. An investigation of three assumptions in the perspective of affective loading follows this up, which confirms the efficiency of borders in psychological meaning production.

  16. Accountings of Selecting Sperm on the (ethical) border

    DEFF Research Database (Denmark)

    Willum Adrian, Stine

    During the past years, Denmark has become a destination for fertility travellers, in need for donated sperm. Today, treatment is possible no matter of marital status or sexuality. Furthermore, users of sperm donation can choose between anonymous and non-anonymous sperm, with either basic...... will analyze how women and their partners crossing the Danish border accounts for their donor choice, and their practices of choosing. I will be exploring the question: How are women and their partners accounting for choosing a sperm donor, crossing the (ethical) border to Denmark? The use of the term...

  17. Disentangling contributions of bar attendance, drinking, and other factors to elevated acute alcohol problems on the U.S.-Mexico border.

    Science.gov (United States)

    Mills, Britain A; Caetano, Raul; Vaeth, Patrice A C; Reingle Gonzalez, Jennifer M

    2015-11-01

    Levels of drinking are unusually elevated among young adults on the U.S.-Mexico border, and this elevation can be largely explained by young border residents' unusually high frequency of bar attendance. However, this explanation complicates interpretation of high alcohol problem rates that have also been observed in this group. Because bar environments can lower the threshold for many types of problems, the extent to which elevated alcohol problems among young border residents can be attributed to drinking per se-versus this common drinking context-is not clear. Data were collected from multistage cluster samples of adult Mexican Americans on and off the U.S.-Mexico border (current drinker N = 1,351). After developing structural models of acute alcohol problems, estimates were subjected to path decompositions to disentangle the common and distinct contributions of drinking and bar attendance to problem disparities on and off the border. Additionally, models were estimated under varying degrees of adjustment to gauge the sensitivity of the results to sociodemographic, social-cognitive, and environmental sources of confounding. Consistent with previous findings for both drinking and other problem measures, acute alcohol problems were particularly elevated among young adults on the border. This elevation was entirely explained by a single common pathway involving bar attendance frequency and drinking. Bar attendance did not predict acute alcohol problems independently of drinking, and its effect was not moderated by border proximity or age. The common indirect effect and its component effects (of border youth on bar attendance, of bar attendance on drinking, and of drinking on problems) were surprisingly robust to adjustment for confounding in all parts of the model (e.g., fully adjusted indirect effect: b = 0.11, SE = 0.04, p Bar attendance and associated increases in drinking play a key, unique role in the high levels of acute alcohol problems among the border

  18. Residual Stress Analysis Based on Acoustic and Optical Methods

    Directory of Open Access Journals (Sweden)

    Sanichiro Yoshida

    2016-02-01

    Full Text Available Co-application of acoustoelasticity and optical interferometry to residual stress analysis is discussed. The underlying idea is to combine the advantages of both methods. Acoustoelasticity is capable of evaluating a residual stress absolutely but it is a single point measurement. Optical interferometry is able to measure deformation yielding two-dimensional, full-field data, but it is not suitable for absolute evaluation of residual stresses. By theoretically relating the deformation data to residual stresses, and calibrating it with absolute residual stress evaluated at a reference point, it is possible to measure residual stresses quantitatively, nondestructively and two-dimensionally. The feasibility of the idea has been tested with a butt-jointed dissimilar plate specimen. A steel plate 18.5 mm wide, 50 mm long and 3.37 mm thick is braze-jointed to a cemented carbide plate of the same dimension along the 18.5 mm-side. Acoustoelasticity evaluates the elastic modulus at reference points via acoustic velocity measurement. A tensile load is applied to the specimen at a constant pulling rate in a stress range substantially lower than the yield stress. Optical interferometry measures the resulting acceleration field. Based on the theory of harmonic oscillation, the acceleration field is correlated to compressive and tensile residual stresses qualitatively. The acoustic and optical results show reasonable agreement in the compressive and tensile residual stresses, indicating the feasibility of the idea.

  19. Immobilization of acid digestion residue

    International Nuclear Information System (INIS)

    Greenhalgh, W.O.; Allen, C.R.

    1983-01-01

    Acid digestion treatment of nuclear waste is similar to incineration processes and results in the bulk of the waste being reduced in volume and weight to some residual solids termed residue. The residue is composed of various dispersible solid materials and typically contains the resultant radioactivity from the waste. This report describes the immobilization of the residue in portland cement, borosilicate glass, and some other waste forms. Diagrams showing the cement and glass virtification parameters are included in the report as well as process steps and candidate waste product forms. Cement immobilization is simplest and probably least expensive; glass vitrification exhibits the best overall volume reduction ratio

  20. Effect of the US-Mexico border region in cardiovascular mortality: ecological time trend analysis of Mexican border and non-border municipalities from 1998 to 2012

    OpenAIRE

    Gabriel Anaya; Wael K Al-Delaimy

    2017-01-01

    Abstract Background An array of risk factors has been associated with cardiovascular diseases, and developing nations are becoming disproportionately affected by such diseases. Cardiovascular diseases have been reported to be highly prevalent in the Mexican population, but local mortality data is poor. The Mexican side of the US-Mexico border has a culture that is closely related to a developed nation and therefore may share the same risk factors of cardiovascular diseases. We wanted to explo...

  1. Evaluation of residue-residue contact predictions in CASP9

    KAUST Repository

    Monastyrskyy, Bohdan

    2011-01-01

    This work presents the results of the assessment of the intramolecular residue-residue contact predictions submitted to CASP9. The methodology for the assessment does not differ from that used in previous CASPs, with two basic evaluation measures being the precision in recognizing contacts and the difference between the distribution of distances in the subset of predicted contact pairs versus all pairs of residues in the structure. The emphasis is placed on the prediction of long-range contacts (i.e., contacts between residues separated by at least 24 residues along sequence) in target proteins that cannot be easily modeled by homology. Although there is considerable activity in the field, the current analysis reports no discernable progress since CASP8.

  2. Tuberculosis-diabetes epidemiology in the border and non-border regions of Tamaulipas, Mexico.

    Science.gov (United States)

    Abdelbary, Bassent E; Garcia-Viveros, Moncerrato; Ramirez-Oropesa, Horacio; Rahbar, Mohammad H; Restrepo, Blanca I

    2016-12-01

    Type 2 diabetes mellitus (DM) is a re-emerging risk factor for TB development and adverse TB outcomes. As a follow-up of our previous study in 1998-2004, we reassessed prevalence of DM and its associated factors among 8431 TB patients using surveillance data from 2006 to 2013 for the Mexican state of Tamaulipas, across the border with Texas. Prevalence of DM was 25.2%, with an increase of at least 2.8% over the study period. Newly discovered factors associated with TB-DM (versus no DM) were lower education and higher unemployment (p pulmonary (versus extra-pulmonary) and drug-resistant TB (1.9-, 3.8- and 1.4-fold, respectively). During treatment, TB-DM patients were more likely to be smear-positive, and less likely to die or abandon TB treatment. Thus, the increasing prevalence of DM among TB, and its association with low education, features of a more contagious TB, and drug resistance, highlight the need for design of TB management programs in DM patients, blood testing of all new TB patients for DM, and if positive for DM, testing for drug resistance. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Processes Underlying Rabies Virus Incursions across US-Canada Border as Revealed by Whole-Genome Phylogeography.

    Science.gov (United States)

    Trewby, Hannah; Nadin-Davis, Susan A; Real, Leslie A; Biek, Roman

    2017-09-01

    Disease control programs aim to constrain and reduce the spread of infection. Human disease interventions such as wildlife vaccination play a major role in determining the limits of a pathogen's spatial distribution. Over the past few decades, a raccoon-specific variant of rabies virus (RRV) has invaded large areas of eastern North America. Although expansion into Canada has been largely prevented through vaccination along the US border, several outbreaks have occurred in Canada. Applying phylogeographic approaches to 289 RRV whole-genome sequences derived from isolates collected in Canada and adjacent US states, we examined the processes underlying these outbreaks. RRV incursions were attributable predominantly to systematic virus leakage of local strains across areas along the border where vaccination has been conducted but also to single stochastic events such as long-distance translocations. These results demonstrate the utility of phylogeographic analysis of pathogen genomes for understanding transboundary outbreaks.

  4. The Ising model for prediction of disordered residues from protein sequence alone

    International Nuclear Information System (INIS)

    Lobanov, Michail Yu; Galzitskaya, Oxana V

    2011-01-01

    Intrinsically disordered regions serve as molecular recognition elements, which play an important role in the control of many cellular processes and signaling pathways. It is useful to be able to predict positions of disordered residues and disordered regions in protein chains using protein sequence alone. A new method (IsUnstruct) based on the Ising model for prediction of disordered residues from protein sequence alone has been developed. According to this model, each residue can be in one of two states: ordered or disordered. The model is an approximation of the Ising model in which the interaction term between neighbors has been replaced by a penalty for changing between states (the energy of border). The IsUnstruct has been compared with other available methods and found to perform well. The method correctly finds 77% of disordered residues as well as 87% of ordered residues in the CASP8 database, and 72% of disordered residues as well as 85% of ordered residues in the DisProt database

  5. 8 CFR 212.6 - Border crossing identification cards.

    Science.gov (United States)

    2010-01-01

    ... Section 212.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS DOCUMENTARY... valid on or after October 1, 2002, the non-biometric border crossing card portion of the document is not... contain a machine-readable biometric identifier, may be admitted on the basis of the nonimmigrant visa...

  6. The Idea of Open Borders: For and Against | Mekonnen | Ethiopian ...

    African Journals Online (AJOL)

    What position one is likely to take concerning immigration depends upon one's general view about the nature of the state, what membership to a political community constitutes and about the legitimacy of state borders. This paper examines the discord of opinions that has marked recent discourses on immigration. After a ...

  7. How Neighbours Communicate: The Role of Language in Border Relations

    Directory of Open Access Journals (Sweden)

    Sonni Olsen

    2014-10-01

    Full Text Available This paper reports on a study of the linguistic situation in the border region where Norway meets Russia in the north. The aim of the study was to investigate language use when contact is revitalised after a long period with closed borders. The Norwegian and Russian languages are very different in vocabulary and structure, which makes communication difficult. How are the two languages affected by extended contact and migration across the border? The study was carried out by the author and Marit Bjerkeng through interviews, a questionnaire and observation of the linguistic situations in two Norwegian communities. The results show an ongoing development where the neighbouring language is increasingly noticeable, and there is a clear link between attitudes, identity and language use. The role of public policy seems to play an important role for the developing linguistic situation, as the Barents region as a political concept introduced in the 1990s has led to cross-border contact within various fields and also inspired local language policy, contributing to cultural pride an

  8. Cross-border Mobility of the Companies in EU

    Directory of Open Access Journals (Sweden)

    Saša Prelič

    2015-01-01

    Full Text Available The fr eedom of establishment, provided by the Treaty on the Functioning of the European Union, is a suitable legal basis for effective cross-border corporate restructuring of companies in European Union. There are some possible methods to exercise this freedom, specially regulated with secondary acts, like cross-border mergers and the establishment and economic operation in the legal form of Societas Europaea, whereas the cross-border transfer of the company (its seat shall be in the light of the case law of the Court of Justice of the European Union admitted on the basis of the Treaty on the Functioning of the European Union. Companies therefore in their intention for cross-border mobility do not need to reconstruct by using the general provisions on establishment and liquidation of companies and through the way of singular succession. There are possibilities, regulated on the EU level, through which companies shall emigrate or spread their business activities to other Member States much simpler and with less cost on the basis of universal succession. The regulation of procedures and the advantages of the mentioned reconstruction methods will be analysed in this article.

  9. 76 FR 41993 - Customs and Border Protection Officer Retirement

    Science.gov (United States)

    2011-07-18

    ... mandatory retirement age); (2) early optional retirement eligibility; (3) enhanced annuity provisions (to... barred from reemployment in any position except a primary position after age 60. Service by a reemployed... Act provides early retirement and enhanced annuity benefits for customs and border protection officers...

  10. Border Crossing Knowledge Systems: A PNG Teacher's Autoethnography

    Science.gov (United States)

    Reta, Medi

    2010-01-01

    Narratives have always been integral to Indigenous knowledge transfer. In this autoethnography the author shares her border crossings between her Indigenous knowledge systems and the often dominant Western knowledge system. Pertinent to these experiences are the stark contrasts that exist between the two knowledge systems and their educational…

  11. Problems concerned with scrap metal monitoring at borders

    International Nuclear Information System (INIS)

    Duftschmid, K.E.

    1997-01-01

    Since the early 1980's numerous incidents have been reported in which radioactive material or empty labelled containers for radioactive sources have been found in scrap metal. Apart from the potential health hazard to employees and the general public resulting costs for decontamination, shutdown of production and waste of products already amounted to multi-million dollar figures. Since the opening of the ''iron border'' in Europe, incidents of illicit trafficking of radioactive sources across borders and contamination of scrap metal imported from the former ''Eastern Countries'' have considerably increased, as a result of the lack of a suitable radiation protection infrastructure in some of these countries. This initiated monitoring of scrap metal transports at the borders of several European countries, such as Austria, Finland, Germany and Italy. Up to now neither universally accepted clearance levels for scrap contamination, nor an agreed standardised procedure for its control exist, although the IAEA as well as the European Commission have proposed some recommendations. As a pragmatic solution for border monitoring it is suggested to apply, as practical clearance level, a dose rate on the outside of the vehicle in the order of 0,1 μSv/h, which is approximately equivalent to double natural environmental background. This dose rate would correspond to an activity concentration for 60 Co in the order of 1 kBq/kg and therefore be in a tolerable range, even in view of products coming in close contact with the public. (author)

  12. Rethinking borders in a mobile world: An alternative model

    DEFF Research Database (Denmark)

    Walther, Olivier; Retaillé, Denis

    2015-01-01

    national borders. The second section elaborates the fundamentals of an alternative model that is not reliant, as is classical spatial analysis, on points, lines and surfaces to represent movement. The article then presents three types of limits: the confines, the threshold and the horizon, which result...

  13. Rethinking borders in a mobile world: An alternative model

    DEFF Research Database (Denmark)

    Walther, Olivier; Retaillé, Denis

    national borders. The second section elaborates the fundamentals of an alternative model that is not reliant, as is classical spatial analysis, on points, lines and surfaces to represent movement. The article then presents three types of limits: the confines, the threshold and the horizon, which result...

  14. Border Pedagogy as a Conduit to Greater Understanding

    Science.gov (United States)

    Cashman, Timothy G.

    2013-01-01

    The article describes a study that was conducted in Malaysia, and at the borders of Chihuahua, Mexico, and Ontario, Canada, to compare the reactions of social studies teachers from Canada, Malaysia, and Mexico to the bombing of Iraq by the U.S. on March 20, 2003. The key objective of the investigations in all three countries was to uncover…

  15. Cross-border Insurance in Europe : Challenges for Supervision

    NARCIS (Netherlands)

    D. Schoenmaker (Dirk); J. Sass (Jan)

    2016-01-01

    markdownabstractAt the start of Solvency II in January 2016, there is no overview of the insurance market in Europe. This paper develops a methodology to link various data sets on foreign branches and subsidiaries. The result is a new and comprehensive data set of cross-border insurance in Europe.

  16. Developing survey metrics for analysing cross-border proximity

    DEFF Research Database (Denmark)

    Makkonen, Teemu; Williams, Allan

    2018-01-01

    attempts to operationalize the varying types of proximity – in relation to CBIC – in the form of a questionnaire tested through pilot studies of two CBRs, at the Finnish–Swedish and Danish–German border, and for two contrasting service industries, namely knowledge-intensive business services and tourism...

  17. Neurodata Without Borders: Creating a Common Data Format for Neurophysiology.

    Science.gov (United States)

    Teeters, Jeffery L; Godfrey, Keith; Young, Rob; Dang, Chinh; Friedsam, Claudia; Wark, Barry; Asari, Hiroki; Peron, Simon; Li, Nuo; Peyrache, Adrien; Denisov, Gennady; Siegle, Joshua H; Olsen, Shawn R; Martin, Christopher; Chun, Miyoung; Tripathy, Shreejoy; Blanche, Timothy J; Harris, Kenneth; Buzsáki, György; Koch, Christof; Meister, Markus; Svoboda, Karel; Sommer, Friedrich T

    2015-11-18

    The Neurodata Without Borders (NWB) initiative promotes data standardization in neuroscience to increase research reproducibility and opportunities. In the first NWB pilot project, neurophysiologists and software developers produced a common data format for recordings and metadata of cellular electrophysiology and optical imaging experiments. The format specification, application programming interfaces, and sample datasets have been released. Copyright © 2015 Elsevier Inc. All rights reserved.

  18. Neurodata Without Borders: Creating a Common Data Format for Neurophysiology

    OpenAIRE

    Teeters, Jeffery L.; Godfrey, Keith; Young, Rob; Dang, Chinh; Friedsam, Claudia; Wark, Barry; Asari, Hiroki; Peron, Simon; Li, Nuo; Peyrache, Adrien; Denisov, Gennady; Siegle, Joshua H.; Olsen, Shawn R.; Martin, Christopher; Chun, Miyoung

    2015-01-01

    The Neurodata Without Borders (NWB) initiative promotes data standardization in neuroscience to increase research reproducibility and opportunities. In the first NWB pilot project, neurophysiologists and software developers produced a common data format for recordings and metadata of cellular electrophysiology and optical imaging experiments. The format specification, application programming interfaces, and sample datasets have been released.

  19. Implementing Problem Based Learning through Engineers without Borders Student Projects

    Science.gov (United States)

    Wittig, Ann

    2013-01-01

    Engineers Without Borders USA (EWB) is a nonprofit organization that partners student chapters with communities in fundamental need of potable water, clean air, sanitation, irrigation, energy, basic structures for schools and clinics, roads and bridges, etc. While EWB projects may vary in complexity, they are all realistic, ill-structured and…

  20. Acculturation and cross-border utilization of health services.

    Science.gov (United States)

    Su, Dejun; Wang, Daphne

    2012-08-01

    Health services from Mexico constitute an important source of care for U.S. residents living along the U.S.-Mexico border. Data from The Cross-Border Utilization of Health Care Survey (n = 966) were used to estimate logit models that related acculturation, as measured by generational status, to the use of medication, physician, dental, and inpatient services from Mexico by U.S. residents in the Texas border region. Relative to first-generation Mexican immigrants, later-generation Mexican-Americans were progressively less likely to go to Mexico for health services. This finding holds with or without adjusting for the effects of selected demographic and socioeconomic variables. Addressing unmet needs in medical care in the southwestern U.S. border area should go beyond a simple expansion of health insurance coverage--it is also important to deliver health services that are sensitive to generational differences within the population in terms of linguistic and cultural barriers to health care access.

  1. Borders in Nigeria’s Relations with Cameroun

    Directory of Open Access Journals (Sweden)

    Omolara Akinyemi

    2014-10-01

    Full Text Available Border incidences are sources of irritants in the relationships between Nigeria and Cameroun. Examples are not far-fetched from Bakassi Peninsula imbroglio leading to hostile relationship between the two countries, and subsequent ruling of Bakassi Peninsula to Cameroun by the International Court of Justice in 2002. Indeed, this also led to the revival of the Joint Cameroun-Nigeria Border Commission entrusted with the task of demarcation of the Land and Maritime boundaries between the two countries, as mandated by the 2002 judgment. However, the demarcation exercise has caused confusion and anxiety with the inhabitants of the Cross River State, Nigeria, resulting in the inability of the team to locate pillar 133A, thereby erecting a new pillar. This exercise is lacking in proper consideration of the effects on the people in the demarcation of the land boundary. Thus, the paper finds out that the demarcationof the Land boundary which the International Court of Justice perceived as the antidote to the border skirmishes between Nigeria and Cameroun is likely to generate to another border conflicts between the two countries. This is so because, the erecting of new pillars will lead to another claim of some parts of Nigeria to Cameroun. Hence, the demarcation of Land boundary if not properly checked may be an outcome of future skirmishes and chaos.

  2. EUROPEAN CROSS-BORDER MERGERS AND ACQUISITIONS- REALITIES AND PERSPECTIVES

    Directory of Open Access Journals (Sweden)

    Vancea Mariana

    2011-07-01

    Full Text Available This paper analyses the impact of the economic and financial crisis on merger and acquisition activity in Europe and the latest trends manifested on the cross-border merger and acquisition market involving European companies. Thus, a first objective of this research is to reveal the evolution of the European cross-border merger and acquisition activity in terms of dynamics, volume and structure. Another objective of this research is to reveal the short and medium term perspectives on mergers and acquisitions in Europe. Thus, under the continuous economic recovery of the European countries and the other worldwide economies, the recovery of financial markets and the growth of corporate profits, we shall witness an intensive cross-border merger and acquisition activity in Europe. The expansion engine of these operations seems to be represented by the emerging economies. This research is based on a systematic, logical and comparative analysis of scientific literature and statistical data regarding the cross-border mergers and acquisitions that involve European companies in recent years. This paper is part of the doctoral thesis Mergers and acquisitions- strategies of growth and development of enterprises. European and national particularities, coordinated by professor Ph.D. Alina Bădulescu from University of Oradea, Faculty of Economics. The doctoral research is supported by The Sectorial Operational Program for Human Resources Development 2007-2013, Contract POSDRU 59/1.5/S/1- Romanian researchers through modern and efficient doctoral programs.

  3. Border Crossing in the Classroom through Performed Ethnography

    Science.gov (United States)

    Goldstein, Tara

    2016-01-01

    In this essay I share the ways I have used performed ethnography to explore the notion of border crossing in an undergraduate course called "Equity and Activism in Education." Performed ethnography involves turning the findings of ethnographic research into a play script. My students read two performed ethnographies, "Harriet's…

  4. Radioactivity in groundwater along the borders of Oman and UAE

    DEFF Research Database (Denmark)

    Murad, A.; Alshamsi, D.; Hou, Xiaolin

    2014-01-01

    Characterizing the quality and radioactivity of groundwater is vital as it represents valuable resource in arid regions. Here we present radioactivity level in groundwater collected from wells in a region along the border between Sultanate of Oman and United Arab Emirates (UAE). The aquifers...

  5. Shifting Institutional Boundaries through Cross-Border Higher Education

    Science.gov (United States)

    Amaral, Alberto; Tavares, Orlanda; Cardoso, Sónia; Sin, Cristina

    2016-01-01

    Cross-border higher education (CBHE) has been changing the organizational boundaries of higher education institutions (HEIs). This study aims to analyze the shifting boundaries of Portuguese HEIs through the lens of the identity concept in organization theories, considering three contexts with different levels of regulation: African…

  6. Surface reconstruction, figure-ground modulation, and border-ownership

    NARCIS (Netherlands)

    Jeurissen, D.; Self, M.W.; Roelfsema, P.R.

    2013-01-01

    The Differentiation-Integration for Surface Completion (DISC) model aims to explain the reconstruction of visual surfaces. We find the model a valuable contribution to our understanding of figure-ground organization. We point out that, next to border-ownership, neurons in visual cortex code whether

  7. Surface reconstruction, figure-ground modulation, and border-ownership

    NARCIS (Netherlands)

    Jeurissen, Danique; Self, Matthew W.; Roelfsema, Pieter R.

    2013-01-01

    Abstract The Differentiation-Integration for Surface Completion (DISC) model aims to explain the reconstruction of visual surfaces. We find the model a valuable contribution to our understanding of figure-ground organization. We point out that, next to border-ownership, neurons in visual cortex code

  8. Cross-Border Takeovers, Corruption, and Related Aspects of Governance

    NARCIS (Netherlands)

    Weitzel, U.; Berns, S.

    We use a panel of 4979 cross-border and domestic takeovers to test the relation between host country corruption and premiums paid for local targets. Host country corruption is negatively associated with target premiums, after correcting for other governance related factors such as political

  9. Bridging Borders: Toward a Pedagogy of Preparedness for Visiting Faculty

    Science.gov (United States)

    Mizzi, Robert C.

    2017-01-01

    This analytical article largely draws on the experiences of visiting faculty teaching at post-secondary institutions overseas. What is largely understood in the literature is that visiting faculty need to navigate the sociocultural, professional, and contextual differences that shape the work context. Drawing on the theory of border pedagogy, this…

  10. Global Liquidity and Drivers of Cross-Border Bank Flows

    NARCIS (Netherlands)

    Cerutti, E.; Claessens, S.; Ratnovski, L.

    2014-01-01

    This paper provides a definition of global liquidity consistent with its meaning as the "ease of financing" in international financial markets. Using a longer time series and broader sample of countries than in previous studies, it identifies global factors driving cross-border bank flows, alongside

  11. beyond the border war: new perspectives on southern africa's late ...

    African Journals Online (AJOL)

    hennie

    In the northern part of Namibia (then called South West Africa) the bush war (or ... they viewed as necessary cross-border-, deep penetration and/or pre-emptive .... The role which media and films can play and have played is illuminated ... Africa like Nazi-Germany years after the Second World War painfully entered this.

  12. The principle of territoriality and cross-border loss compensation

    NARCIS (Netherlands)

    Marres, O.

    2011-01-01

    Member States are free to define their income tax base. They may in principle disregard foreign-sourced income, resulting in the impossibility of cross-border loss compensation. The European Court of Justice (ECJ) has accepted the principle of territoriality as a criterion for the division of the

  13. Leading Change with Slogans: Border University in Transition

    Science.gov (United States)

    Gonzales, Leslie D.; Pacheco, Arturo

    2012-01-01

    In this study, the authors problematize the use of slogans when it comes to leading major organizational change. Specifically, they outline the slogans that Border University leaders used to explain and justify the university's transition from a regional, primarily teaching-focused university to an aspiring nationally recognized, Tier One research…

  14. School Leadership Challenges along Kenya's Borabu-Sotik Border

    Science.gov (United States)

    Abaya, Joel

    2016-01-01

    This article is based on a qualitative multi-case study carried out in southwestern Kenya along the border areas of Nyanza and Rift Valley province. The purpose of the research was to examine the challenges public secondary school principals faced in their leadership roles and suggest efforts they might adopt to minimize the effects of these…

  15. Gender, Cross-border Migrant Workers and Citizenship : Case Study ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Burmese women workers in Thai border factories are generally excluded from the benefits and protection that define citizenship entitlements. ... have little or no access to basic services, including health and education for themselves or their dependents. ... New funding opportunity for gender equality and climate change.

  16. Frontier and Border Regions in Early Modern Europe

    NARCIS (Netherlands)

    Esser, R.M.; Ellis, Steven G.

    2013-01-01

    That regional identities are constructed is now something of a truism in academic research. More recently regions have been conceptualized in the framework of Frontier and Border Studies, thus emphasizing their relationship to their neighbours in another state across a boundary line. In early modern

  17. beyond the border war: new perspectives on southern africa's late ...

    African Journals Online (AJOL)

    hennie

    Price: R 265.00 (SA): R273.00 ; Euros: 34.00 ; (R578.00 through Kalahari.net) ... they viewed as necessary cross-border-, deep penetration and/or pre-emptive .... transgressions with long term consequences which will evoke international law.

  18. Winning hearts and minds in the Namibian border war

    African Journals Online (AJOL)

    Lieneke

    2010-08-13

    Aug 13, 2010 ... During the Namibian border war, South African counterinsurgency doctrine ... US Army General Staff in 1966 his book, The Art of Counter-Revolutionary War –. The Strategy of Counter-Insurgency, was published. .... of ability, management capabilities or work ethic, the white civil servant opted to do the job ...

  19. Cross-border Co-operation Networks in West Africa

    DEFF Research Database (Denmark)

    Walther, Olivier

    Long seen as artificial barriers inherited from decolonisation, West African borders now lie at the heart of policies designed to encourage regional trade and combat political instability. This rediscovery of the peripheries of the nation state has fostered a proliferation of institutional...

  20. Eliminating national borders as labour market barriers in the EU

    NARCIS (Netherlands)

    van Lieshout, Harm

    2012-01-01

    This paper addresses one important mechanism through which the EU tries to improve the operation of its labour markets: the opening up of national borders for free worker movement within the EU. Free worker movement is a fundamental EU right; but EU enlargement begged the question of how and when to

  1. Cross-Border Movements, Female Migration and Human Rights : a ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    This project will examine the relationship between migration, prostitution and trafficking with respect to cross-border movement of women between three South Asian countries: Bangladesh, India and Nepal. Researchers will. conduct an extensive review of the literature on female migration in the three countries;; examine ...

  2. Airline loyalty (programs) across borders : A geographic discontinuity approach

    NARCIS (Netherlands)

    de Jong, Gerben; Behrens, Christiaan; van Ommeren, Jos

    2018-01-01

    We analyze brand loyalty advantages of national airlines in their domestic countries using geocoded data from a major international frequent flier program. We employ a geographic discontinuity design that estimates discontinuities in program activity at the national borders of the program's

  3. Taeniasis among Refugees Living on Thailand-Myanmar Border, 2012.

    Science.gov (United States)

    McCleery, Ellen J; Patchanee, Prapas; Pongsopawijit, Pornsawan; Chailangkarn, Sasisophin; Tiwananthagorn, Saruda; Jongchansittoe, Papaspong; Dantrakool, Anchalee; Morakote, Nimit; Phyu, Hnin; Wilkins, Patricia P; Noh, John C; Phares, Christina; O'Neal, Seth

    2015-10-01

    We tested refugee camp residents on the Thailand-Myanmar border for Taenia solium infection. Taeniasis prevalence was consistent with that for other disease-endemic regions, but seropositivity indicating T. solium taeniasis was rare. Seropositivity indicating cysticercosis was 5.5% in humans, and 3.2% in pigs. Corralling pigs and providing latrines may control transmission of these tapeworms within this camp.

  4. Immunoelectrophoretic studies on pig intestinal brush border proteins

    DEFF Research Database (Denmark)

    Danielsen, Erik Michael; Sjöström, H; Norén, O

    1977-01-01

    Brush borders were prepared from pig intestinal mucosa and the membrane proteins solubilized with either Triton X-100 or papain. Proteins, thus released, were used as antigens to raise antisera in rabbits. The immunoglobulin G fractions were isolated and shown by the double layer immunofluorescence...

  5. Landfilling of waste incineration residues

    DEFF Research Database (Denmark)

    Christensen, Thomas Højlund; Astrup, Thomas; Cai, Zuansi

    2002-01-01

    Residues from waste incineration are bottom ashes and air-pollution-control (APC) residues including fly ashes. The leaching of heavy metals and salts from the ashes is substantial and a wide spectrum of leaching tests and corresponding criteria have been introduced to regulate the landfilling...

  6. Mapping the membrane-aqueous border for the voltage-sensing domain of a potassium channel.

    Science.gov (United States)

    Neale, Edward J; Rong, Honglin; Cockcroft, Christopher J; Sivaprasadarao, Asipu

    2007-12-28

    Voltage-sensing domains (VSDs) play diverse roles in biology. As integral components, they can detect changes in the membrane potential of a cell and couple these changes to activity of ion channels and enzymes. As independent proteins, homologues of the VSD can function as voltage-dependent proton channels. To sense voltage changes, the positively charged fourth transmembrane segment, S4, must move across the energetically unfavorable hydrophobic core of the bilayer, which presents a barrier to movement of both charged species and protons. To reduce the barrier to S4 movement, it has been suggested that aqueous crevices may penetrate the protein, reducing the extent of total movement. To investigate this hypothesis in a system containing fully functional channels in a native environment with an intact membrane potential, we have determined the contour of the membrane-aqueous border of the VSD of KvAP in Escherichia coli by examining the chemical accessibility of introduced cysteines. The results revealed the contour of the membrane-aqueous border of the VSD in its activated conformation. The water-inaccessible regions of S1 and S2 correspond to the standard width of the membrane bilayer (~28 A), but those of S3 and S4 are considerably shorter (> or = 40%), consistent with aqueous crevices pervading both the extracellular and intracellular ends. One face of S3b and the entire S3a were water-accessible, reducing the water-inaccessible region of S3 to just 10 residues, significantly shorter than for S4. The results suggest a key role for S3 in reducing the distance S4 needs to move to elicit gating.

  7. Early evidence of San material culture represented by organic artifacts from Border Cave, South Africa.

    Science.gov (United States)

    d'Errico, Francesco; Backwell, Lucinda; Villa, Paola; Degano, Ilaria; Lucejko, Jeannette J; Bamford, Marion K; Higham, Thomas F G; Colombini, Maria Perla; Beaumont, Peter B

    2012-08-14

    Recent archaeological discoveries have revealed that pigment use, beads, engravings, and sophisticated stone and bone tools were already present in southern Africa 75,000 y ago. Many of these artifacts disappeared by 60,000 y ago, suggesting that modern behavior appeared in the past and was subsequently lost before becoming firmly established. Most archaeologists think that San hunter-gatherer cultural adaptation emerged 20,000 y ago. However, reanalysis of organic artifacts from Border Cave, South Africa, shows that the Early Later Stone Age inhabitants of this cave used notched bones for notational purposes, wooden digging sticks, bone awls, and bone points similar to those used by San as arrowheads. A point is decorated with a spiral groove filled with red ochre, which closely parallels similar marks that San make to identify their arrowheads when hunting. A mixture of beeswax, Euphorbia resin, and possibly egg, wrapped in vegetal fibers, dated to ∼40,000 BP, may have been used for hafting. Ornaments include marine shell beads and ostrich eggshell beads, directly dated to ∼42,000 BP. A digging stick, dated to ∼39,000 BP, is made of Flueggea virosa. A wooden poison applicator, dated to ∼24,000 BP, retains residues with ricinoleic acid, derived from poisonous castor beans. Reappraisal of radiocarbon age estimates through bayesian modeling, and the identification of key elements of San material culture at Border Cave, places the emergence of modern hunter-gatherer adaptation, as we know it, to ∼44,000 y ago.

  8. Statistical inference on residual life

    CERN Document Server

    Jeong, Jong-Hyeon

    2014-01-01

    This is a monograph on the concept of residual life, which is an alternative summary measure of time-to-event data, or survival data. The mean residual life has been used for many years under the name of life expectancy, so it is a natural concept for summarizing survival or reliability data. It is also more interpretable than the popular hazard function, especially for communications between patients and physicians regarding the efficacy of a new drug in the medical field. This book reviews existing statistical methods to infer the residual life distribution. The review and comparison includes existing inference methods for mean and median, or quantile, residual life analysis through medical data examples. The concept of the residual life is also extended to competing risks analysis. The targeted audience includes biostatisticians, graduate students, and PhD (bio)statisticians. Knowledge in survival analysis at an introductory graduate level is advisable prior to reading this book.

  9. Risk management of infrastructure development in border area Indonesia - Malaysia

    Science.gov (United States)

    Fitri, Suryani; Trikariastoto, Reinita, Ita

    2017-11-01

    Border area is geographically adjacent to neighboring countries with the primary function of maintaining state sovereignty and public welfare. Area in question is part of the provinces, districts or cities that directly intersect with national boundaries (or territory) and / or that have a functional relationship (linkage) and has a strategic value for the state. The border area is considered strategic because it involves the national lives of many people in terms of the interests of political, economic, social and cultural as well as defense and security (poleksosbudhankam) both located on land, sea or air. The border area is geographically adjacent to neighboring countries with the primary function of maintaining state sovereignty and public welfare. Area in question is part of the provinces, districts or cities that directly intersect with national boundaries (or territory) and / or that have a functional relationship (linkage) and has a strategic value for the state. To realize the necessary research on the development of the area, based on good practices from other countries some of the city that can meet all these challenges and at least can be applied with minor changes / adjustments. Furthermore, the application must be supported by the availability of funds. This study to discuss about any problems either obstacles or things that drive to develop function becomes an ideal border area with major support infrastructure for housing, transportation, energy availability, and distribution of clean water which will strengthen in its function which consists of five pillars, namely: central community service; trade and distribution center; financial center; tourism center; related to the field of community development. Articulation between key stakeholders such as government, private, and community is a major concern in this study, including in determining the appropriate financing schemes. The results of this study will be recommended to the government to improve

  10. A Voice of the US Southwestern Border: The 2012 “We the Border: Envisioning a Narrative for Our Future” Conference

    Directory of Open Access Journals (Sweden)

    Josiah McC. Heyman

    2013-08-01

    Full Text Available In July 2012, a diverse group of US residents living near the US-Mexico border met in El Paso, Texas for a conference entitled, We the Border: Envisioning a Narrative for Our Future.  This paper describes a vision for the US-Mexico border by diverse border residents that is at odds with the widespread view of the border as a threat to the United States. These border residents viewed their region as a set of human communities with rights, capacities, and valuable insights and knowledge. They embraced an alternative vision of border enforcement that would focus on “quality” (dangerous entrants and contraband over “quantity” (mass migration enforcement.  They called for investments in the functionality and security of ports of entry, rather than in between ports of entry.  They noted the low crime rate in US border cities, and examined how policies of not mixing local law enforcement with federal immigration enforcement contributed to this achievement. They saw the border region as the key transportation and brokerage zone of the emerging, integrated North American economy. In their view, the bilingual, bicultural, and binational skills that characterize border residents form part of a wider border culture that embraces diversity and engenders creativity. Under this vision the border region is not an empty enforcement zone, but is part of the national community and its residents should enjoy the same constitutional and human rights as other US residents. The conference participants emphasized the necessity and value of accountability and oversight of central government enforcement operations, and the need for border communities to participate in federal decision-making that affects their lives. 

  11. Jobs at the Borders: What policies can promote gender equality and ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Jobs at the Borders: What policies can promote gender equality and growth ... The development of border economic zones represents an important ... provides opportunities for two of its poor neighbouring countries, Cambodia and Myanmar.

  12. Virtual Borders Between Chile and Its Neighbors: Argentina, Peru and Bolivia

    National Research Council Canada - National Science Library

    Palma, Alberto E

    2007-01-01

    .... It is based on which economy breaks with the previous scheme, and the possibilities of conflict beyond the borders of countries, where the interests collide, although that geographic space is distant from the recognized borders.

  13. Structure of the vitreoretinal border region in spontaneously hypertensive rats (SHR rats)

    DEFF Research Database (Denmark)

    Heegaard, Steffen

    1993-01-01

    Øjenpatologi, vitreoretinal border region, inner limiting membrane of the retina, spontaneously hypertensive rats, SHR rats, ultrastructure......Øjenpatologi, vitreoretinal border region, inner limiting membrane of the retina, spontaneously hypertensive rats, SHR rats, ultrastructure...

  14. Barreloid Borders and Neuronal Activity Shape Panglial Gap Junction-Coupled Networks in the Mouse Thalamus.

    Science.gov (United States)

    Claus, Lena; Philippot, Camille; Griemsmann, Stephanie; Timmermann, Aline; Jabs, Ronald; Henneberger, Christian; Kettenmann, Helmut; Steinhäuser, Christian

    2018-01-01

    The ventral posterior nucleus of the thalamus plays an important role in somatosensory information processing. It contains elongated cellular domains called barreloids, which are the structural basis for the somatotopic organization of vibrissae representation. So far, the organization of glial networks in these barreloid structures and its modulation by neuronal activity has not been studied. We have developed a method to visualize thalamic barreloid fields in acute slices. Combining electrophysiology, immunohistochemistry, and electroporation in transgenic mice with cell type-specific fluorescence labeling, we provide the first structure-function analyses of barreloidal glial gap junction networks. We observed coupled networks, which comprised both astrocytes and oligodendrocytes. The spread of tracers or a fluorescent glucose derivative through these networks was dependent on neuronal activity and limited by the barreloid borders, which were formed by uncoupled or weakly coupled oligodendrocytes. Neuronal somata were distributed homogeneously across barreloid fields with their processes running in parallel to the barreloid borders. Many astrocytes and oligodendrocytes were not part of the panglial networks. Thus, oligodendrocytes are the cellular elements limiting the communicating panglial network to a single barreloid, which might be important to ensure proper metabolic support to active neurons located within a particular vibrissae signaling pathway. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  15. Institutionalizing cross-border cooperatives on European level in the energy sector

    International Nuclear Information System (INIS)

    Paulusma, A.C.

    2008-01-01

    The third energy package proposes the establishment of an Agency for the Cooperation of Energy Regulators (ACER) and the establishment of a European Network of Transmission System Operators for Electricity (ENTSOE) and a European Network of Transmission System Operators for Gas (ENTSOG). This legislative initiative is a response to the need to further liberalise the energy sector and to create one single energy market. The proposals wish to remedy the lack of regulatory oversight for cross border issues and the existence of a regulatory gap on cross-border issues. This article addresses these proposals and places them in a historical context. The proposals indicate that the European legislator to some degree intends to institutionalize cross border cooperation of regulators and of transmission system operators. So far cross-border cooperation mostly has been brought about on a voluntary basis and not on the basis of European law. Also this cooperation takes place on a voluntary basis and largely outside the scope of the European Commission. If the proposals are excepted they will result in new forms of cooperation in the energy sector. The Agency will be a community body with legal personality that, besides having an advisory role, will in some circumstances be able to take binding decisions. Therefore it will entail more than voluntary cooperation and be a step closer to the establishment of a European regulator. With the creation of ENTSOG and ENTSOE cooperation between transmission system operators will for the first time be obligatory and take place on the basis of European legislation. It will therefore be a new phenomenon. Nevertheless, it is not always clear from the proposals what the result in practice will be nor how the new organizations will relate to each other, to the Commission and to the national regulators and transmission system operators. Currently, the main question is whether the proposals will be adopted by the Council and the European

  16. The Utopia of Cross-border Regions. Territorial transformation and Cross-Border Governance on Espace Mont-Blanc

    NARCIS (Netherlands)

    Lissandrello, E.

    2006-01-01

    The theories on globalisation, internationalisation, post-nationalism or trans-nationalism dismiss the concept of 'territoriality' within the paradigm of the beyond the 'nation-state' sovereignty. In this work, a diverse idea is sustained: borders and territoriality are not just lost terms within

  17. The borders that divide, the borders that unite: (Re)interpreting Garo Processes of identification in India and Bangladesh

    NARCIS (Netherlands)

    Bal, E.W.; Claquin-Chambugong, T.

    2014-01-01

    The people known as Garos, from the Garo Hills and adjacent (lowland) areas in India and Bangladesh, have never constituted one unified and self-defined in-group, although British colonial rule indeed produced a feeble notion of an imagined Garo community. Hence, the international border of 1947

  18. Cross-border transitions : Navigating conflict and political change through community education practices in Myanmar and the Thai border

    NARCIS (Netherlands)

    Maber, E.J.T.

    2016-01-01

    Political oscillations in Myanmar and Thailand, between militarisation and democratic reform, have prompted a rapid renegotiation of the alignments, goals and priorities of non-state education providers, both international and community-based, along the two countries’ border. This paper explores the

  19. Literacies Crossing Borders: Transfronterizo Literacy Practices of Students in a Dual Language Program on the USA-Mexico Border

    Science.gov (United States)

    de la Piedra, Maria Teresa; Araujo, Blanca E.

    2012-01-01

    Research on transnational literacies has generally focused on youth who live in one country and communicate using digital literacies across national boundaries. Our work contributes to this literature by providing a view of transnational literacies that are unique to the USA-Mexico border region. The students in this ethnographic study navigate…

  20. Cross-Border Transitions: Navigating Conflict and Political Change through Community Education Practices in Myanmar and the Thai Border

    Science.gov (United States)

    Maber, Elizabeth J. T.

    2016-01-01

    Political oscillations in Myanmar and Thailand, between militarisation and democratic reform, have prompted a rapid renegotiation of the alignments, goals and priorities of non-state education providers, both international and community-based, along the two countries' border. This paper explores the responses to shifts in political environment…

  1. Changing Destinations: Ideal Attraction and Actual Movement of Cross-Border Tertiary Students from Mainland China

    Science.gov (United States)

    Ghazarian, Peter G.

    2014-01-01

    Globalization has driven growth in the market for cross-border students. Mainland China, with a burgeoning economy and the largest national population, has become an important source of cross-border students. This study identifies ideal attraction in mainland China to destinations for cross-border tertiary education, as expressed by ideal first…

  2. Stories of the "Boring Border". The Dutch-German Borderscape in People's Minds

    NARCIS (Netherlands)

    Strüver, A.

    2004-01-01

    This dissertation examines the 'open' Dutch-German border and people's everyday practices in relation to this border within the context of Dutch-German relations and the process of European integration. For, despite the opening of this border in 1993, it has not disappeared and continues to form an

  3. The U.S.-Canada Border Effect : Smaller Than Previously Thought and Becoming Smaller

    Science.gov (United States)

    2012-05-30

    We revisit the effect of the U.S.-Canada national border on trade, considering to what extent the border reduces trade when : observable economic factors are controlled. A reexamination of the data yields estimates of the border effect that are 50% :...

  4. Inverting the Telescope on Borders that Matter: Conversations in Café Europa

    NARCIS (Netherlands)

    Anderson, D.J.; Kramsch, O.T.; Sandberg, M.

    2015-01-01

    Proposing an ‘inverted telescope’ for border studies, we problematized existing calls to ‘see like a border’, arguing that such moves miss an opportunity to define what is properly political about b/ordering space. Inverting the telescope on borders that matter reveals an ontologically grounded

  5. Caught on the Mexican-US Border: The Insecurity and Desire of Collaboration between Two Universities

    Science.gov (United States)

    Maldonado-Maldonado, Alma; Cantwell, Brendan

    2008-01-01

    Understandings of cross-border university collaboration are often informed by a concept of internationalisation that privileges the rationales of university administrators. A case study of two asymmetric universities along the border of Mexico and the United States--one of the most active and problematic borders in the world--found that, rather…

  6. Socio-cultural proximity, daily life and shopping tourism in the Dutch–German border region

    NARCIS (Netherlands)

    Szytniewski, Bianca B.; Spierings, Bas; van der Velde, Martin

    2017-01-01

    This paper analyses feelings of socio-cultural proximity and distance with a specific focus on the tourist experience in cross-border shopping and everyday life practices in border regions. We examined shopping practices of Dutch border crossers who visit the German town Kleve in the Dutch–German

  7. Residual stress by repair welds

    International Nuclear Information System (INIS)

    Mochizuki, Masahito; Toyoda, Masao

    2003-01-01

    Residual stress by repair welds is computed using the thermal elastic-plastic analysis with phase-transformation effect. Coupling phenomena of temperature, microstructure, and stress-strain fields are simulated in the finite-element analysis. Weld bond of a plate butt-welded joint is gouged and then deposited by weld metal in repair process. Heat source is synchronously moved with the deposition of the finite-element as the weld deposition. Microstructure is considered by using CCT diagram and the transformation behavior in the repair weld is also simulated. The effects of initial stress, heat input, and weld length on residual stress distribution are studied from the organic results of numerical analysis. Initial residual stress before repair weld has no influence on the residual stress after repair treatment near weld metal, because the initial stress near weld metal releases due to high temperature of repair weld and then stress by repair weld regenerates. Heat input has an effect for residual stress distribution, for not its magnitude but distribution zone. Weld length should be considered reducing the magnitude of residual stress in the edge of weld bead; short bead induces high tensile residual stress. (author)

  8. Illegal Immigration: Is the Use of Military Force in Policing the United states' Border with Mexico a Viable Option?

    National Research Council Canada - National Science Library

    Lopez, David

    2001-01-01

    Illegal immigration across the United States' borders, in particular the Southern Border with Mexico, has been a continual problem confronting our local, state and national political decision makers...

  9. Niclosamide residues in milk and organs of lactating goats

    International Nuclear Information System (INIS)

    El Hindi, A.M.; Sidra, M.S.

    1986-01-01

    14 C-Niclosamide was administered to two groups of lactating goats at levels of 2ppm for five consecutive days and 10ppm as a single dose. Residues of the molluscicide in milk, if at all present, did not exceed 0.001 ppm at any time. About 50% of the administered activity was excreted in faeces, while 30% excreted through urine in animals surviving 6 days after withdrawal. The unchanged molluscicide is present only in relatively trace amounts. The highest residues in organs were found in the liver of both groups (0.01-0.04 ppm). From the results it could be concluded that absorbed niclosamide is completely metabolised and rapidly eliminated through urine, leaving little or no residues of the unchanged molluscicide. Little or no residues were detected in lean muscles and milk which are consumed by humans. There is no preferential deposition of the molluscicide or its metabolites in fat

  10. RESIDUAL RISK ASSESSMENT: ETHYLENE OXIDE ...

    Science.gov (United States)

    This document describes the residual risk assessment for the Ethylene Oxide Commercial Sterilization source category. For stationary sources, section 112 (f) of the Clean Air Act requires EPA to assess risks to human health and the environment following implementation of technology-based control standards. If these technology-based control standards do not provide an ample margin of safety, then EPA is required to promulgate addtional standards. This document describes the methodology and results of the residual risk assessment performed for the Ethylene Oxide Commercial Sterilization source category. The results of this analyiss will assist EPA in determining whether a residual risk rule for this source category is appropriate.

  11. ITRAP - an international pilot study on border monitoring systems

    International Nuclear Information System (INIS)

    Beck, P.; Duftschmid, K.E.

    1999-01-01

    The paper describes the design and preliminary results of an extended pilot study of commercially available monitoring systems for the detection of nuclear and other radioactive materials at borders. The study consists of a laboratory test phase and field tests at the Austrian/Hungarian border and the Vienna airport, each for a duration of one year. The results will be used to derive realistic performance requirements for border control systems in view of optimized technical and economic conditions as well as to propose an 'investigation level'. The ITRAP study consists of three phases. In the first phase equipment currently available on the market is subjected to laboratory testing at the Austrian Research Centres Seibersdorf. The instrument categories include hand-held, portable, and fixed-installed equipment. The test criteria defined as minimum requirements have been established together with the manufacturers. The laboratory tests started in May 1998 and will last until end of this year. During the second phase, the field study, equipment passing the laboratory tests will be installed at a major Austrian-Hungarian border crossing (Nickelsdorf) for monitoring of cars, trucks and trains, as well as at the Vienna airport for pedestrians, luggage and cargo. In this phase the results gained from the lab tests about the 'fitness for use' will be verified in practice, in close co-operation with the law enforcement officers at the borders. Also training issues and questions of maintenance and support shall be evaluated. In the third phase, realistic specifications and performance requirements shall be derived with the help of international experts and selected specialists from the users and manufacturers. The results of the field study will focus not only on the technical aspects of monitoring equipment (e.g. detection threshold and rate of false alarms) but also on the operational (e.g. ease of use, reliability, training requirements, field support) and economic

  12. The Hippo pathway controls border cell migration through distinct mechanisms in outer border cells and polar cells of the Drosophila ovary.

    Science.gov (United States)

    Lin, Tzu-Huai; Yeh, Tsung-Han; Wang, Tsu-Wei; Yu, Jenn-Yah

    2014-11-01

    The Hippo pathway is a key signaling cascade in controlling organ size. The core components of this pathway are two kinases, Hippo (Hpo) and Warts (Wts), and a transcriptional coactivator, Yorkie (Yki). Yes-associated protein (YAP, a Yki homolog in mammals) promotes epithelial-mesenchymal transition and cell migration in vitro. Here, we use border cells in the Drosophila ovary as a model to study Hippo pathway functions in cell migration in vivo. During oogenesis, polar cells secrete Unpaired (Upd), which activates JAK/STAT signaling of neighboring cells and specifies them into outer border cells. The outer border cells form a cluster with polar cells and undergo migration. We find that hpo and wts are required for migration of the border cell cluster. In outer border cells, overexpression of hpo disrupts polarization of the actin cytoskeleton and attenuates migration. In polar cells, knockdown of hpo and wts or overexpression of yki impairs border cell induction and disrupts migration. These manipulations in polar cells reduce JAK/STAT activity in outer border cells. Expression of upd-lacZ is increased and decreased in yki and hpo mutant polar cells, respectively. Furthermore, forced expression of upd in polar cells rescues defects of border cell induction and migration caused by wts knockdown. These results suggest that Yki negatively regulates border cell induction by inhibiting JAK/STAT signaling. Together, our data elucidate two distinct mechanisms of the Hippo pathway in controlling border cell migration: (1) in outer border cells, it regulates polarized distribution of the actin cytoskeleton; (2) in polar cells, it regulates upd expression to control border cell induction and migration. Copyright © 2014 by the Genetics Society of America.

  13. Nitrogen availability of biogas residues

    Energy Technology Data Exchange (ETDEWEB)

    El-Sayed Fouda, Sara

    2011-09-07

    The objectives of this study were to characterize biogas residues either unseparated or separated into a liquid and a solid phase from the fermentation of different substrates with respect to their N and C content. In addition, short and long term effects of the application of these biogas residues on the N availability and N utilization by ryegrass was investigated. It is concluded that unseparated or liquid separated biogas residues provide N at least corresponding to their ammonium content and that after the first fertilizer application the C{sub org}:N{sub org} ratio of the biogas residues was a crucial factor for the N availability. After long term application, the organic N accumulated in the soil leads to an increased release of N.

  14. Technical note: Equivalent genomic models with a residual polygenic effect.

    Science.gov (United States)

    Liu, Z; Goddard, M E; Hayes, B J; Reinhardt, F; Reents, R

    2016-03-01

    Routine genomic evaluations in animal breeding are usually based on either a BLUP with genomic relationship matrix (GBLUP) or single nucleotide polymorphism (SNP) BLUP model. For a multi-step genomic evaluation, these 2 alternative genomic models were proven to give equivalent predictions for genomic reference animals. The model equivalence was verified also for young genotyped animals without phenotypes. Due to incomplete linkage disequilibrium of SNP markers to genes or causal mutations responsible for genetic inheritance of quantitative traits, SNP markers cannot explain all the genetic variance. A residual polygenic effect is normally fitted in the genomic model to account for the incomplete linkage disequilibrium. In this study, we start by showing the proof that the multi-step GBLUP and SNP BLUP models are equivalent for the reference animals, when they have a residual polygenic effect included. Second, the equivalence of both multi-step genomic models with a residual polygenic effect was also verified for young genotyped animals without phenotypes. Additionally, we derived formulas to convert genomic estimated breeding values of the GBLUP model to its components, direct genomic values and residual polygenic effect. Third, we made a proof that the equivalence of these 2 genomic models with a residual polygenic effect holds also for single-step genomic evaluation. Both the single-step GBLUP and SNP BLUP models lead to equal prediction for genotyped animals with phenotypes (e.g., reference animals), as well as for (young) genotyped animals without phenotypes. Finally, these 2 single-step genomic models with a residual polygenic effect were proven to be equivalent for estimation of SNP effects, too. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  15. Valve arrangement for a nuclear plant residual heat removal system

    International Nuclear Information System (INIS)

    Fidler, G.L.; Hill, R.A.; Carrera, J.P.

    1978-01-01

    Disclosed is an improved valve arrangement for a two-train Residual Heat Removal System (RHRS) of a nuclear reactor plant which ensures operational integrity of the system under single failure circumstances including loss of one of two electrical power sources

  16. AN ALTERNATIVE APPROACH TO THE USE OF HEAVY OIL RESIDUE

    Directory of Open Access Journals (Sweden)

    Eugene Dashut

    2013-01-01

    Full Text Available We consider an alternative approach to the existing oil refining, in which instead of a single priority that emerged in the traditional approach, we consider two: get the light component and a heavy residue used for the production of new construction materials.

  17. Disentangling value creation mechanism in cross-border acquisitions

    DEFF Research Database (Denmark)

    Wang, Daojuan; Sørensen, Olav Jull; Moini, Hamid

    2016-01-01

    This study investigates the value creation mechanism in cross-border acquisitions ( CBAs ) by employing a structural equation modeling technique and surveying 103 CBAs performed by Nordic firms. The results reveal that resource possession, resource picking, and resource utilization are three impo...... in this study, is an important step forward in merger and acquisition (M&A) research. Moreover, numerous research findings offer tactical implications for international acquirers.......This study investigates the value creation mechanism in cross-border acquisitions ( CBAs ) by employing a structural equation modeling technique and surveying 103 CBAs performed by Nordic firms. The results reveal that resource possession, resource picking, and resource utilization are three...... important strategic dimensions for realizing synergy and creating value in CBAs . Furthermore, mediation analysis shows that the two acquisition-based dynamic capabilities—value identification and resource reconfiguration—act as important mediators in how the joining firms’ resource base impacts acquisition...

  18. Fuel tourism in border regions: The case of Switzerland

    Energy Technology Data Exchange (ETDEWEB)

    Banfi, S.; Filippini, M. [Swiss Federal Institute of Technology, Zurich (Switzerland). Department of Management, Technology and Economics, Centre for Energy Policy and Economics; Universita della Svizzera italiana, Lugano (Switzerland). Istituto di microeconomia e economia Pubblica; Hunt, L.C. [University of Surrey (United Kingdom). Department of Economics, Surrey Energy Economics Centre

    2005-09-01

    This paper explores the issue of 'fuel tourism' in Switzerland. For the period 1985-1997, a panel data model for the border regions of Switzerland, (Italy, France, and Germany) is estimated. The results show a significant impact of the gasoline price differential on demand, suggesting that a decrease of 10% in the Swiss gasoline price leads to an increase in demand in the border areas of nearly 17.5%. It is shown that fuel tourism accounted for about 9% of overall gasoline sales in the three regions during the period 1985-1997 and that the recently proposed Swiss CO{sub 2}-tax might, given current conditions, eliminate net fuel tourism. (author)

  19. Radiation Control on Uzbekistan Borders - Results and Perspectives

    International Nuclear Information System (INIS)

    Petrenko, Vitaliy; Yuldashev, Bekhzod; Ismailov, Ulughbek; Shipilov, Nikolay; Chipizubov, Sergey; Avezov, Anvar

    2009-01-01

    The measures and actions on prevention, detection and response to criminal or unauthorized acts involving radioactive materials in Uzbekistan are presented. In frames of program of radiation monitoring to prevent illicit trafficking of nuclear and radioactive materials main customs border checkpoints were equipped with commercial radiation portal monitors. Special radiation monitors elaborated and manufactured in INP AS RU are installed in INP(main gates, research reactor and laboratory building) to provide nuclear security of Institute facilities. The experience of Uzbekistan in establishing radiation monitoring systems on its borders, their operation and maintenance would be useful for realization of proposed plan of strengthening measures to prevent illicit trafficking in Republics of Central Asia region.

  20. Nationalist Reconstructions in the Face of the Disappearance of Borders

    Directory of Open Access Journals (Sweden)

    Ferhat Kentel

    2008-09-01

    Full Text Available Together with the conflictive negotiation abouth the definition and the feeling of nation, on a strategic level, the repercussions of globalisation (and especially the negotiations with the European Union are complicating the border issue and, as a consequence, the issue of unity (which is “always in danger”, according to the nationalist-Kemalist elites. The nationalist discourse is consumed on a popular level but, rather than simple consumption or pure strategic production, it is constituted as the production of different nationalisms in the tactics of everyday life. In this way, this article tackles the subject of the new nationalist productions, examining more deeply the tactics that range from survival to subversion or new religious rites in a situation of uncertainties and ambivalences brought about by globalisation, by a new encounter with the West and by the disappearance of borders.

  1. The complete mitochondrial genome of the Border Collie dog.

    Science.gov (United States)

    Wu, An-Quan; Zhang, Yong-Liang; Li, Li-Li; Chen, Long; Yang, Tong-Wen

    2016-01-01

    Border Collie dog is one of the famous breed of dog. In the present work we report the complete mitochondrial genome sequence of Border Collie dog for the first time. The total length of the mitogenome was 16,730 bp with the base composition of 31.6% for A, 28.7% for T, 25.5% for C, and 14.2% for G and an A-T (60.3%)-rich feature was detected. It harbored 13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNA genes and one non-coding control region (D-loop region). The arrangement of all genes was identical to the typical mitochondrial genomes of dogs.

  2. Vesícula residual

    Directory of Open Access Journals (Sweden)

    Júlio C. U. Coelho

    Full Text Available Our objective is to report three patients with recurrent severe upper abdominal pain secondary to residual gallbladder. All patients had been subjected to cholecystectomy from 1 to 20 years before. The diagnosis was established after several episodes of severe upper abdominal pain by imaging exams: ultrasonography, tomography, or endoscopic retrograde cholangiography. Removal of the residual gallbladder led to complete resolution of symptoms. Partial removal of the gallbladder is a very rare cause of postcholecystectomy symptoms.

  3. Residual number processing in dyscalculia ?

    OpenAIRE

    Cappelletti, Marinella; Price, Cathy J.

    2013-01-01

    Developmental dyscalculia – a congenital learning disability in understanding numerical concepts – is typically associated with parietal lobe abnormality. However, people with dyscalculia often retain some residual numerical abilities, reported in studies that otherwise focused on abnormalities in the dyscalculic brain. Here we took a different perspective by focusing on brain regions that support residual number processing in dyscalculia. All participants accurately performed semantic and ca...

  4. Americium recovery from reduction residues

    Science.gov (United States)

    Conner, W.V.; Proctor, S.G.

    1973-12-25

    A process for separation and recovery of americium values from container or bomb'' reduction residues comprising dissolving the residues in a suitable acid, adjusting the hydrogen ion concentration to a desired level by adding a base, precipitating the americium as americium oxalate by adding oxalic acid, digesting the solution, separating the precipitate, and thereafter calcining the americium oxalate precipitate to form americium oxide. (Official Gazette)

  5. Identification of Key Residues for Enzymatic Carboxylate Reduction

    Directory of Open Access Journals (Sweden)

    Holly Stolterfoht

    2018-02-01

    Full Text Available Carboxylate reductases (CARs, E.C. 1.2.1.30 generate aldehydes from their corresponding carboxylic acid with high selectivity. Little is known about the structure of CARs and their catalytically important amino acid residues. The identification of key residues for carboxylate reduction provides a starting point to gain deeper understanding of enzymatic carboxylate reduction. A multiple sequence alignment of CARs with confirmed activity recently identified in our lab and from the literature revealed a fingerprint of conserved amino acids. We studied the function of conserved residues by multiple sequence alignments and mutational replacements of these residues. In this study, single-site alanine variants of Neurospora crassa CAR were investigated to determine the contribution of conserved residues to the function, expressability or stability of the enzyme. The effect of amino acid replacements was investigated by analyzing enzymatic activity of the variants in vivo and in vitro. Supported by molecular modeling, we interpreted that five of these residues are essential for catalytic activity, or substrate and co-substrate binding. We identified amino acid residues having significant impact on CAR activity. Replacement of His 237, Glu 433, Ser 595, Tyr 844, and Lys 848 by Ala abolish CAR activity, indicating their key role in acid reduction. These results may assist in the functional annotation of CAR coding genes in genomic databases. While some other conserved residues decreased activity or had no significant impact, four residues increased the specific activity of NcCAR variants when replaced by alanine. Finally, we showed that NcCAR wild-type and mutants efficiently reduce aliphatic acids.

  6. [The health of migrants at the Greece-Macedonia border].

    Science.gov (United States)

    Moutamalle, Raphaël

    2016-01-01

    At the border between Greece and Macedonia, a transit camp for refugees is turning into a permanent camp. The management of the health emergency is assured by international teams from several humanitarian organisations, including the French Red Cross. The organisation of the care team, the cultural differences and the lack of resources are just some of the factors to be considered. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  7. The Sino-Indian Border: Is Conflict Inevitable?

    Science.gov (United States)

    2013-12-13

    relationship between China and India may be thought in terms of a gestalt theory . The basis of the gestalt theory is that before perceiving different...greater than the sum of the parts” is often used to explain gestalt theory .33 Analysts on both sides often view their relations as the sum of border...Most often, hawkish views grab the headlines.”56 This adds to the Sino-Indian gestalt and form perception about each other based on viewpoints of

  8. Survey of Technologies for the Airport Border of the Future

    Science.gov (United States)

    2014-04-01

    layout; they are burgundy in colour with the words "European Union" printed on the cover, accompanied by the name of the issuing EU State. Schengen...34 psychological priming" or " psychological cueing" or crowd w/2 (density or model* or control or management) Airport Border of the Future March 2014...http://en.wikipedia.org/wiki/Handwriting_recognition Iris recognition Iris recognition involves analyzing the features in the coloured tissue

  9. Cross-Border Patent Infringement Litigation within the European Union

    OpenAIRE

    Kant, Michael Christian Alexander

    2015-01-01

    In our modern industrial society, intellectual property (IP) rights, and in particular patents, constitute for many companies and individuals the essential basis for their business activity. In light of this, adequate protection of IP rights is of crucial importance for such entities. Within the European legal framework, the Brussels Ibis Regulation provides for specific rules with regard to cross-border patent infringement proceedings which however contain considerable deficiencies when it c...

  10. Istrian folk narrative tradition from the perspective of changing borders:

    OpenAIRE

    Kropej, Monika

    2013-01-01

    This paper focuses on the folk narrative tradition of Istria, which reflect the area's cultural landscape as well as the everyday life of its inhabitants. Presented is an overview of the changing narrative tradition in the area situated along presently disappearing formal state borders within the expanded European Union. The author explores older studies and research conducted by contemporary scholars who focused their scholarly interest in the spiritual culture of this area. Special interest...

  11. Bastion on the Border: Fort Bliss, 1854-1943

    Science.gov (United States)

    1993-01-01

    Journals , Record Group (RG) 165, Records of the War Department General and Special Staffs, National Archives, Washington, D.C. "’Richard Estrada, Border...it was the Fort Bliss garrison and the other troops deployed by Steever in the El Paso Patrol District that would have to provide the figurative glue ...little military value. For example, on March 30 three carloads of oats, flour , corn, and hay were dispatched; on April 7 fourteen carloads of hay, gasoline

  12. Refining borders of genome-rearrangements including repetitions

    Directory of Open Access Journals (Sweden)

    JA Arjona-Medina

    2016-10-01

    Full Text Available Abstract Background DNA rearrangement events have been widely studied in comparative genomic for many years. The importance of these events resides not only in the study about relatedness among different species, but also to determine the mechanisms behind evolution. Although there are many methods to identify genome-rearrangements (GR, the refinement of their borders has become a huge challenge. Until now no accepted method exists to achieve accurate fine-tuning: i.e. the notion of breakpoint (BP is still an open issue, and despite repeated regions are vital to understand evolution they are not taken into account in most of the GR detection and refinement methods. Methods and results We propose a method to refine the borders of GR including repeated regions. Instead of removing these repetitions to facilitate computation, we take advantage of them using a consensus alignment sequence of the repeated region in between two blocks. Using the concept of identity vectors for Synteny Blocks (SB and repetitions, a Finite State Machine is designed to detect transition points in the difference between such vectors. The method does not force the BP to be a region or a point but depends on the alignment transitions within the SBs and repetitions. Conclusion The accurate definition of the borders of SB and repeated genomic regions and consequently the detection of BP might help to understand the evolutionary model of species. In this manuscript we present a new proposal for such a refinement. Features of the SBs borders and BPs are different and fit with what is expected. SBs with more diversity in annotations and BPs short and richer in DNA replication and stress response, which are strongly linked with rearrangements.

  13. Measuring the Effectiveness of Border Security Between Ports of Entry

    Science.gov (United States)

    2010-01-01

    ts of migration. Massey, Durand, and Malone (2003) argue that neoclassical theory has limited explanatory power and, in fact, that immigration is...interpreted in the context of dif- ferent theories of how and why immigration occurs. Various theories explain immigration— for example, as a migrant’s...Durand, and Malone, 2003). One theory of how border security aff ects migration is that migrants employ a cost-benefi t calculation when deciding

  14. The Uzbekistan Kyrgyzstan Border: Institutional Legitimacy and Regional Stability

    Science.gov (United States)

    2017-06-01

    and Lenzi Sherfedinov, “Land, Water, and Ecology ,” in Ferghana Valley, edited by Starr, 255. 18 challenges face this region, including terrorism...see Robert Nisbet, The Quest for Community: A Study in the Ethics of Order and Freedom (Wilmington, DE: ISI Books, 2010), originally published by... ecological problems.”377 These security challenges are not only interrelated but also dependent on the condition of state borders. As Karimov

  15. Keseimbangan Kerja Keluarga pada Perempuan Bekerja: Tinjauan Teori Border

    OpenAIRE

    Arri Handayani

    2015-01-01

    Nowadays, working women are common phenomena. However, the involvement of women in the working career has both positive and negative impacts for the individual women, their family and their organisation as well. To minimize those negative impacts, these working women are required to balance their roles both in working and family ranahs. Border theory was used for discussing the work family balance, with the assumption that the interaction between working environment and family environme...

  16. Cross-Border Takeovers, Corruption, and Related Aspects of Governance

    OpenAIRE

    U. Weitzel; S. Berns

    2006-01-01

    We use a panel of 4979 cross-border and domestic takeovers to test the relation between host country corruption and premiums paid for local targets. Host country corruption is negatively associated with target premiums, after correcting for other governance-related factors such as political stability, legal systems, and financial disclosure standards. We estimate that deterioration in the corruption index by one point (on a 10-point scale) is, on average, associated with a reduction of 21&per...

  17. Nationalist Reconstructions in the Face of the Disappearance of Borders

    OpenAIRE

    Ferhat Kentel

    2008-01-01

    Together with the conflictive negotiation abouth the definition and the feeling of nation, on a strategic level, the repercussions of globalisation (and especially the negotiations with the European Union) are complicating the border issue and, as a consequence, the issue of unity (which is “always in danger”, according to the nationalist-Kemalist elites). The nationalist discourse is consumed on a popular level but, rather than simple consumption or pure strategic production, it is constitut...

  18. Progressive Retinal Atrophy in the Border Collie: A new XLPRA

    OpenAIRE

    Vilboux, Thierry; Chaudieu, Gilles; Jeannin, Patricia; Delattre, Delphine; Hedan, Benoit; Bourgain, Catherine; Queney, Guillaume; Galibert, Francis; Thomas, Anne; André, Catherine

    2008-01-01

    Abstract Background Several forms of progressive retinal atrophy (PRA) segregate in more than 100 breeds of dog with each PRA segregating in one or a few breeds. This breed specificity may be accounted for by founder effects and genetic drift, which have reduced the genetic heterogeneity of each breed, thereby facilitating the identification of causal mutations. We report here a new form of PRA segregating in the Border Collie breed. The clinical signs, including the loss of night vision and ...

  19. Corneal squamous cell carcinoma in a Border Collie.

    Science.gov (United States)

    Busse, Claudia; Sansom, Jane; Dubielzig, R R; Hayes, Alison

    2008-01-01

    A 6-year-old, female, spayed Border Collie was presented to the Unit of Comparative Ophthalmology at the Animal Health Trust with a 6-month history of a progressive nonpainful opacity of the left cornea. A keratectomy was performed and the tissue submitted for histopathology. The diagnosis was squamous cell carcinoma. There has been no recurrence of the neoplasm to date (5 months). Canine corneal squamous cell carcinoma (SCC) has not been reported previously in the UK.

  20. Taeniasis among Refugees Living on Thailand–Myanmar Border, 2012

    Science.gov (United States)

    Patchanee, Prapas; Pongsopawijit, Pornsawan; Chailangkarn, Sasisophin; Tiwananthagorn, Saruda; Jongchansittoe, Papaspong; Dantrakool, Anchalee; Morakote, Nimit; Phyu, Hnin; Wilkins, Patricia P.; Noh, John C.; Phares, Christina; O’Neal, Seth

    2015-01-01

    We tested refugee camp residents on the Thailand–Myanmar border for Taenia solium infection. Taeniasis prevalence was consistent with that for other disease-endemic regions, but seropositivity indicating T. solium taeniasis was rare. Seropositivity indicating cysticercosis was 5.5% in humans, and 3.2% in pigs. Corralling pigs and providing latrines may control transmission of these tapeworms within this camp. PMID:26401787