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Sample records for single point turning

  1. Geometry of single-point turning tools and drills

    CERN Document Server

    Astakhov, Viktor P

    2010-01-01

    Tools for metal cutting have many shapes and features, each of which is described by its angles or geometries. The selection of the right cutting tool geometry is critical because it directly affects the integrity of the machined surface, tool life, power needed for machining, and thus the overall machining efficiency. ""Geometry of Single-Point Turning Tools and Drills"" outlines clear objectives of cutting tool geometry selection and optimization, using multiple examples to provide a thorough explanation. The establishment of clear bridges between cutting theory, tool geometry, and shop prac

  2. An application of eddy current damping effect on single point diamond turning of titanium alloys

    Science.gov (United States)

    Yip, W. S.; To, S.

    2017-11-01

    Titanium alloys Ti6Al4V (TC4) have been popularly applied in many industries. They have superior material properties including an excellent strength-to-weight ratio and corrosion resistance. However, they are regarded as difficult to cut materials; serious tool wear, a high level of cutting vibration and low surface integrity are always involved in machining processes especially in ultra-precision machining (UPM). In this paper, a novel hybrid machining technology using an eddy current damping effect is firstly introduced in UPM to suppress machining vibration and improve the machining performance of titanium alloys. A magnetic field was superimposed on samples during single point diamond turning (SPDT) by exposing the samples in between two permanent magnets. When the titanium alloys were rotated within a magnetic field in the SPDT, an eddy current was generated through a stationary magnetic field inside the titanium alloys. An eddy current generated its own magnetic field with the opposite direction of the external magnetic field leading a repulsive force, compensating for the machining vibration induced by the turning process. The experimental results showed a remarkable improvement in cutting force variation, a significant reduction in adhesive tool wear and an extreme long chip formation in comparison to normal SPDT of titanium alloys, suggesting the enhancement of the machinability of titanium alloys using an eddy current damping effect. An eddy current damping effect was firstly introduced in the area of UPM to deliver the results of outstanding machining performance.

  3. An application of eddy current damping effect on single point diamond turning of titanium alloys

    International Nuclear Information System (INIS)

    Yip, W S; To, S

    2017-01-01

    Titanium alloys Ti6Al4V (TC4) have been popularly applied in many industries. They have superior material properties including an excellent strength-to-weight ratio and corrosion resistance. However, they are regarded as difficult to cut materials; serious tool wear, a high level of cutting vibration and low surface integrity are always involved in machining processes especially in ultra-precision machining (UPM). In this paper, a novel hybrid machining technology using an eddy current damping effect is firstly introduced in UPM to suppress machining vibration and improve the machining performance of titanium alloys. A magnetic field was superimposed on samples during single point diamond turning (SPDT) by exposing the samples in between two permanent magnets. When the titanium alloys were rotated within a magnetic field in the SPDT, an eddy current was generated through a stationary magnetic field inside the titanium alloys. An eddy current generated its own magnetic field with the opposite direction of the external magnetic field leading a repulsive force, compensating for the machining vibration induced by the turning process. The experimental results showed a remarkable improvement in cutting force variation, a significant reduction in adhesive tool wear and an extreme long chip formation in comparison to normal SPDT of titanium alloys, suggesting the enhancement of the machinability of titanium alloys using an eddy current damping effect. An eddy current damping effect was firstly introduced in the area of UPM to deliver the results of outstanding machining performance. (paper)

  4. Ultrasonically Assisted Single Point Diamond Turning of Optical Mold of Tungsten Carbide

    Directory of Open Access Journals (Sweden)

    Zhanjie Li

    2018-02-01

    Full Text Available To realize high efficiency, low/no damage and high precision machining of tungsten carbide used for lens mold, a high frequency ultrasonic vibration cutting system was developed at first. Then, tungsten carbide was precisely machined with a polycrystalline diamond (PCD tool assisted by the self-developed high frequency ultrasonic vibration cutting system. Tool wear mechanism was investigated in ductile regime machining of tungsten carbide. The cutter back-off phenomenon in the process was analyzed. The subsequent experimental results of ultra-precision machining with a single crystal diamond tool showed that: under the condition of high frequency ultrasonic vibration cutting, nano-scale surface roughness can be obtained by the diamond tool with smaller tip radius and no defects like those of ground surface were found on the machined surface. Tool wear mechanisms of the single crystal diamond tool are mainly abrasive wear and micro-chipping. To solve the problem, a method of inclined ultrasonic vibration cutting with negative rake angle was put forward according to force analysis, which can further reduce tool wear and roughness of the machined surface. The investigation was important to high efficiency and quality ultra-precision machining of tungsten carbide.

  5. The Philosophy of Turning Points

    DEFF Research Database (Denmark)

    Turcan, Romeo V.

    2013-01-01

    This paper introduces and discusses the concept of turning points from the ontological, epistemological, and methodological perspectives, applying it to the de-internationalization phenomenon to exemplify its deployment. As a concept that adds to the variance and complexity of the international b...

  6. Turning points in reactor design

    Energy Technology Data Exchange (ETDEWEB)

    Beckjord, E.S.

    1995-09-01

    This article provides some historical aspects on nuclear reactor design, beginning with PWR development for Naval Propulsion and the first commercial application at Yankee Rowe. Five turning points in reactor design and some safety problems associated with them are reviewed: (1) stability of Dresden-1, (2) ECCS, (3) PRA, (4) TMI-2, and (5) advanced passive LWR designs. While the emphasis is on the thermal-hydraulic aspects, the discussion is also about reactor systems.

  7. Turning points in reactor design

    International Nuclear Information System (INIS)

    Beckjord, E.S.

    1995-01-01

    This article provides some historical aspects on nuclear reactor design, beginning with PWR development for Naval Propulsion and the first commercial application at Yankee Rowe. Five turning points in reactor design and some safety problems associated with them are reviewed: (1) stability of Dresden-1, (2) ECCS, (3) PRA, (4) TMI-2, and (5) advanced passive LWR designs. While the emphasis is on the thermal-hydraulic aspects, the discussion is also about reactor systems

  8. Kantian Turning Point in Gadamer's Philosophical Hermeneutics

    Directory of Open Access Journals (Sweden)

    Kristína Bosáková

    2016-11-01

    Full Text Available The paper is treating the theme of a Kantian turning-point in the philosophical hermeneutics of H.- G. Gadamer based on of the harmonic relationship between metaphysics and science in Kantian philosophy from the point of view of the philosophical hermeneutics of Gadamer. The philosophical work of Kant had such an influence on Gadamer that without exaggerating we can talk about the Kantian turning-point in Gadamerian hermeneutics. Grondin, a former student of Gadamer, is talking about Kantian turning-point on the field of aesthetics, but in reality Kantian turning-point means much more than a mere change in the reception of the concept of judgement. It is a discovery of harmonical relationship between the beauty and the moral, between the reason and the sensitivity, between the modern sciences and the metaphysical tradition in the Kantian philosophy, made by Gadamer. This is what we call the Kantian turning-point in Gadamerian hermeneutics.

  9. Turning points in the history of mathematics

    CERN Document Server

    Grant, Hardy

    2015-01-01

    This book explores some of the major turning points in the history of mathematics, ranging from ancient Greece to the present, demonstrating the drama that has often been a part of its evolution. Studying these breakthroughs, transitions, and revolutions, their stumbling-blocks and their triumphs, can help illuminate the importance of the history of mathematics for its teaching, learning, and appreciation. Some of the turning points considered are the rise of the axiomatic method (most famously in Euclid), and the subsequent major changes in it (for example, by David Hilbert); the “wedding,” via analytic geometry, of algebra and geometry; the “taming” of the infinitely small and the infinitely large; the passages from algebra to algebras, from geometry to geometries, and from arithmetic to arithmetics; and the revolutions in the late nineteenth and early twentieth centuries that resulted from Georg Cantor’s creation of transfinite set theory. The origin of each turning point is discussed, along with...

  10. Turning points in climate change adaptation

    Directory of Open Access Journals (Sweden)

    Saskia Elisabeth. Werners

    2015-12-01

    Full Text Available Concerned decision makers increasingly pose questions as to whether current management practices are able to cope with climate change and increased climate variability. This signifies a shift in the framing of climate change from asking what its potential impacts are to asking whether it induces policy failure and unacceptable change. In this paper, we explore the background, feasibility, and consequences of this new framing. We focus on the specific situation in which a social-political threshold of concern is likely to be exceeded as a result of climate change, requiring consideration of alternative strategies. Action is imperative when such a situation is conceivable, and at this point climate change becomes particularly relevant to decision makers. We call this situation an "adaptation turning point." The assessment of adaptation turning points converts uncertainty surrounding the extent of a climate impact into a time range over which it is likely that specific thresholds will be exceeded. This can then be used to take adaptive action. Despite the difficulty in identifying adaptation turning points and the relative newness of the approach, experience so far suggests that the assessment generates a meaningful dialogue between stakeholders and scientists. Discussion revolves around the amount of change that is acceptable; how likely it is that unacceptable, or more favorable, conditions will be reached; and the adaptation pathways that need to be considered under these circumstances. Defining and renegotiating policy objectives under climate change are important topics in the governance of adaptation.

  11. Diamond turning of Si and Ge single crystals

    Energy Technology Data Exchange (ETDEWEB)

    Blake, P.; Scattergood, R.O.

    1988-12-01

    Single-point diamond turning studies have been completed on Si and Ge crystals. A new process model was developed for diamond turning which is based on a critical depth of cut for plastic flow-to-brittle fracture transitions. This concept, when combined with the actual machining geometry for single-point turning, predicts that {open_quotes}ductile{close_quotes} machining is a combined action of plasticity and fracture. Interrupted cutting experiments also provide a meant to directly measure the critical depth parameter for given machining conditions.

  12. China's nuclear industry at a turning point

    International Nuclear Information System (INIS)

    Kubota, Hideo

    2009-01-01

    The China nuclear industry is coming at a turning point since the first Chinese nuclear power plant of Qinshan No.1 was started construction 24 years ago. At the end of year 2008, there are 11 nuclear power plants in operation in China. The total power capacity of the facilities has reached to 9068MW. It resulted in 11th position next to Sweden. Despite the nuclear power was reached to 68.4 billion KWh, it makes up only 2% of the total electric generation in China. The thermal power takes 81% of the total generation, in which the power by coal fuel takes for the most part and the total generation by both natural gas and oil fuel take only as small as a few percentage. In this situation, a nuclear power plant development is being accelerated. As of July 2009, China has 15 nuclear power plants currently under construction with a total capacity of 15260MW, that is more than 24000MW together with ones currently in operation. Furthermore, my research shows that China would have a plan to build 180 new nuclear power plants of 192770MW, though the progress varies widely. The construction speed of China nuclear power plant has become increasingly high since 2008. Starting with the construction of. Ningde unit 1 (PWR, 1110MW) in Fujian Province, February 2008, they continuously started constructions for five more nuclear power plants in year 2008 alone. China still holds momentum in a nuclear power plant construction even in 2009, and continues constructing new nuclear power plants. They include a Liaoning. Hongyanhe unit 3 in March, Sanmen Zhejiang April 19 which lead a construction first in the world for the third generation nuclear power plant of AP1000 (PWR, 1250MW) developed by Westinghouse, Fuqing unit 2 (PWR, 1000MW) June 17, and Fangjiashan unit 2 (PWR, 1000MW) on 17, July. Besides, Shidaowan, Rongcheng phase I (200MW), which is a demonstration reactor of HTGR in Shandong. They even said that China would start construction for approximately 7 to 9 nuclear power

  13. A falling of the veils: turning points and momentous turning points in leadership and the creation of CSR

    OpenAIRE

    Hemingway, C.; Starkey, Kenneth

    2017-01-01

    This article uses the life stories approach to leadership and leadership development. Using exploratory, qualitative data from a Forbes Global 2000 and FTSE 100 company, we discuss the role of the turning point (TP) as an important antecedent of leadership in corporate social responsibility. We argue that TPs are causally efficacious, linking them to the development of life narratives concerned with an evolving sense of personal identity. Using both a multi-disciplinary perspective and a mult...

  14. Brokdorf - the symbol for a political turning-point

    International Nuclear Information System (INIS)

    Aust, S.

    1981-01-01

    Brokdorf - this spot in the North of the F.R. of Germany designates a front which is no longer the only place where the argument of 'yes' or 'no' to nuclear energy is discussed. The citizens have lost their confidence in the competence of those governing, some concerns have betrayed them, politicians have lied, and the sufficiently-known German shortsightedness has kept up celebrating tradition - this is what has happened during the seven years' war about the Brokdorf nuclear power plant. For even without nuclear power the lights won't go out and the unemployment figures will not increase. In the meantime the heavy protests of environmentally-minded citizens against an industrial power which is solely orientated towards competition has seized all strata of our society. Now, since a handful of politicians are also timidly beginning to refuse to submit themselves to the alleged forces underlying the existing circumstances, the conflict between big industry and governmental power is programmed at least as far as topics of energy policy are concerned. A political turning-point. Or does the atomic state show its teeth because it is afraid of the democratic formation of a common will of those who it used to consider as an incapacitated herd of voters. (orig.) [de

  15. [Adult health problems and coping at life turning points].

    Science.gov (United States)

    Lee, Sheuan; Lu, Ying-Chi; Yen, Wen-Jiuan; Lin, Shu-Chin

    2004-02-01

    At important life turning points, middle-aged adults face many physiological changes (e.g., aging, changes in hormone levels) and alterations in family structure (e.g., children growing up and leaving home). In addition to facing these changes and their impacts, adults must also take on challenges in terms of self-concept, body image, life goals, and life meaning. Illnesses that commonly occur during this life stage include menopausal depression, substance abuse, and anxiety. Traditional treatment models are medical-oriented, but curative effects are limited and hospital visits still occur at high frequencies, resulting in increased medical expenses and disruptions in family life. The authors review the current literature on curative models in this area, and discuss the potential of a combination of physical therapy, cognitive, and existential-humanistic therapy to improve patients' physical strength, self-concept, self-esteem, and self-confidence in an effort to overcome physio-psycho-social disorders and to increase vitality.

  16. The German energetic turning point: year n+2

    International Nuclear Information System (INIS)

    Cruciani, Michel

    2013-07-01

    This publication proposes an analysis of the evolution of the German energy sector, two years after the adoption of a new energy policy. It notably aims at identifying the consequences of this important turning point which was characterised by the decision to phase out nuclear while keeping on reducing energy consumption and greenhouse gas emissions, and developing renewable energies. In a first part, the author comments the objectives associated with the present evolution in terms of reducing the primary energy consumption, reducing raw electric power consumption, energy consumption in transports, CO 2 emissions, of increasing the share of renewable energies and power production from renewable sources, and of complying with European objectives. The second part discusses technical aspects of the development of power generation from renewable sources by addressing the following issues: prospective, grid extension and strengthening, intermittency management, industrial orientation. The third part addresses economic aspects of this development: promotion of electricity production from renewable sources, relationship between power generation from renewable sources and electricity price, public debate on electricity price, employment and economic benefits, financing the energy transition, and the European dimension. In conclusion, the author discusses whether the German energy shift is a model or a counter-example

  17. What can be seen beyond the turning points?

    International Nuclear Information System (INIS)

    Morita, Koji

    1997-01-01

    LNG markets in Asia has faced turning points in 1990s. There is sluggish growth of Japanese demand, rapid demand growth of Korea and Taiwan, and increase of dependency on the Middle East. Will these situation continue after 2000? In Japan, energy demand will grow steadily, and development of nuclear power stations will not proceed without difficulty. Considering the emission of carbon dioxide, LNG demand will expand more than the Government outlook of 68 ∼ 60 mil. tons in 2010. IEEJ (Institute of Energy Economics Japan) forecasts that it will come to 58 mil. tons in 2010, including 1 ∼ 2 mil. tons of indigenous production. Korea secured two LNG projects newly, Ras Laffan (Qatar) and Oman. Considering the secured volume, LNG consumption will continue to expand even after 2000. But thinking of the lesser population of 21 mil. and warm climate of Taiwan, the extent of LNG demand expansion may not be so large. Big unknown factors exist in Asia: China and India. Their large population can give a great influence on LNG market in Asia. Several gas-fired power projects by IPP are already being planned. According to the Indian Government, as annual production capacity of natural gas is limited, more than 40 bil. m 3 must be fulfilled by import in 2005. Some indicators of China, GDP, energy consumption and so on, are saying that Shanghai and some cities may have already prepared conditions to introduce LNG. They may begin to utilize LNG by taking surplus of existing LNG projects in the later half of 2000s. (LN)

  18. O turning point da grande reportagem multimídia

    OpenAIRE

    Longhi, Raquel Ritter; Universidade Federal de Santa Catarina / Campus Reitor João David Ferreira Lima. Florianópolis, Santa Catarina. Brasil. CEP: 88049-900 Tel: (48) 3721.9000

    2015-01-01

    Este artigo analisa o estado da arte da grande reportagem multimídia no jornalismo online, atentando para um momento que se pode definir como “turning point”, ou ponto de virada desse tipo de formato noticioso. A partir de uma sistematização da evolução dos formatos expressivos multimidiáticos da notícia no jornalismo digital, o artigo identifica três momentos principais dessa trajetória: o slide-show noticioso, no início dos anos 2000; os especiais multimídia, de meados de 2000 a 2011 e a gr...

  19. Refugees and Europe: a dilemma or a turning point?

    Directory of Open Access Journals (Sweden)

    Helgard Mahrdt

    2015-04-01

    Full Text Available Europe is facing a wave of refugees and migrants. To solve the many inherent problems is primarily a practical political task. However, there are existential experiences, democratic values, human attitudes, and political principles involved, and I am going to look particularly to the following three aspects of the refugee crisis, 1 the existential (I refer to the philosopher Martin Heidegger and to the political thinker Hannah Arendt, 2 the political (I turn to the EU’s steps for a common refugee policy, and 3 the legal (I refer to Immanuel Kant’s notion of hospitality and Seyla Benhabib’s notes on Human Rights. Finally, I will make a concluding remark on education’s task (I refer to Hannah Arendt’s and Aristotle’s notion of philia.

  20. Single-Mode WGM Resonators Fabricated by Diamond Turning

    Science.gov (United States)

    Grudinin, Ivan; Maleki, Lute; Savchenkov, Anatoliy; Matsko, Andrewy; Strekalov, Dmitry; Iltchenko, Vladimir

    2008-01-01

    A diamond turning process has made possible a significant advance in the art of whispering-gallery-mode (WGM) optical resonators. By use of this process, it is possible to fashion crystalline materials into WGM resonators that have ultrahigh resonance quality factors (high Q values), are compact (ranging in size from millimeters down to tens of microns), and support single electromagnetic modes. This development combines and extends the developments reported in "Few- Mode Whispering-Gallery-Mode Resonators" (NPO-41256), NASA Tech Briefs, Vol. 30, No. 1 (January 2006), page 16a and "Fabrication of Submillimeter Axisymmetric Optical Components" (NPO-42056), NASA Tech Briefs, Vol. 31, No. 5 (May 2007), page 10a. To recapitulate from the first cited prior article: A WGM resonator of this special type consists of a rod, made of a suitable transparent material, from which protrudes a thin circumferential belt of the same material. The belt is integral with the rest of the rod and acts as a circumferential waveguide. If the depth and width of the belt are made appropriately small, then the belt acts as though it were the core of a single-mode optical fiber: the belt and the rod material adjacent to it support a single, circumferentially propagating mode or family of modes. To recapitulate from the second cited prior article: A major step in the fabrication of a WGM resonator of this special type is diamond turning or computer numerically controlled machining of a rod of a suitable transparent crystalline material on an ultrahigh-precision lathe. During the rotation of a spindle in which the rod is mounted, a diamond tool is used to cut the rod. A computer program is used to control stepping motors that move the diamond tool, thereby controlling the shape cut by the tool. Because the shape can be controlled via software, it is possible to choose a shape designed to optimize a resonator spectrum, including, if desired, to limit the resonator to supporting a single mode

  1. EU ECONOMIC GOVERNANCE REFORM: ARE WE AT A TURNING POINT?

    Directory of Open Access Journals (Sweden)

    Daniel Daianu

    2011-03-01

    Full Text Available The sovereign debt crisis is creating enormous anguish in the European Monetary Union (EMU. Not surprisingly, emergency measures continue to be used at a time when a sort of economic recovery seems to be underway. Against this background the European Council summit of last October considered a Task Force report with a telling name: "Strengthening economic governance in the EU". This document is to be examined in conjunction with the governance reform proposals issued by the European Commission at the end of September and related documents. For the depth of this financial crisis and the "Great Recession" have forced EU governments and EU institutions to take a hard look at the governance structure of the Union. But it would be wrong to say that this demarche is an attempt to explore a terra incognita. From the very beginning of the European Monetary Union (EMU there was some discomfort with its institutional underpinnings and there were misgivings regarding its optimality as a currency area. This explains why a train of thought underlines a political rationale, too, for the creation of the EMU. Likewise, criticism regarding the way regulation and supervision have been established in the Union is not of recent vintage. And insufficiencies of the Stability and Growth Pact (SGP, with almost all member states flouting its rules at various points in time, have been repeatedly pointed out. This said, however, the flaws of financial intermediation have been less tackled by policy-makers and central bankers for reasons which, partially, are to be found in a paradigm which has dominated economic thinking in recent decades. This paper focuses on roots of the huge strain in the EU (EMU and main policy issues ensuing from the current crisis. It also looks at the stake NMSs have in a reformed EU economic governance structure. The challenges for EU economic governance reform are to be seen from a broad perspective: the crisis of the financial intermediation

  2. Turning Points during the Life of Student Project Teams: A Qualitative Study

    Science.gov (United States)

    Raes, Elisabeth; Kyndt, Eva; Dochy, Filip

    2015-01-01

    In this qualitative study a more flexible alternative of conceptualising changes over time in teams is tested within student project teams. The conceptualisation uses turning points during the lifespan of a team to outline team development, based on work by Erbert, Mearns, & Dena (2005). Turning points are moments that made a significant…

  3. Turning point

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2000-06-30

    A conference of delegates from First Nations communities in coastal British Columbia was held in May 2000 in Vancouver to discuss how they could work together to ensure the protection of ancestral lands and waters for future generations. The conference also provided the opportunity for the First Nations representatives to sign a declaration articulating their collective responsibilities as stewards of the land and expressing strong commitment to cooperation on a regional basis to approach settlement of issues regarding forestry and fisheries in ways that benefit both the communities and the environment. Delegates also expressed frustration with government and industry who continue to make decisions about resources on traditional lands ignoring the constitutional rights of First Nations peoples. The discussions reflected participants' intense concern about current resource management practices to sustain either the ecological system of the region or the communities dependent on them for their livelihood and their cultural identity.

  4. Decision tree learning for detecting turning points in business process orientation: a case of Croatian companies

    Directory of Open Access Journals (Sweden)

    Ljubica Milanović Glavan

    2015-03-01

    Full Text Available Companies worldwide are embracing Business Process Orientation (BPO in order to improve their overall performance. This paper presents research results on key turning points in BPO maturity implementation efforts. A key turning point is defined as a component of business process maturity that leads to the establishment and expansion of other factors that move the organization to the next maturity level. Over the past few years, different methodologies for analyzing maturity state of BPO have been developed. The purpose of this paper is to investigate the possibility of using data mining methods in detecting key turning points in BPO. Based on survey results obtained in 2013, the selected data mining technique of classification and regression trees (C&RT was used to detect key turning points in Croatian companies. These findings present invaluable guidelines for any business that strives to achieve more efficient business processes.

  5. Turning point revisited: launching the next generation of performance management in public health.

    Science.gov (United States)

    DeAngelo, Julia W; Beitsch, Leslie M; Beaudry, Margaret L; Corso, Liza C; Estes, Larissa J; Bialek, Ron G

    2014-01-01

    A decade ago, the Turning Point Performance Management Excellence Collaborative (Turning Point) developed the first public health-specific performance management (PM) system, with accompanying resource materials, assisted by the Public Health Foundation. Since then, dramatic advancements in PM and quality improvement activities have occurred in public health. Public Health Foundation gathered data that revealed Turning Point was still relevant but difficult to implement within public health. To reflect recent advances and current challenges, Public Health Foundation refreshed the Turning Point model and related guidance tools and developed new resources to facilitate PM implementation. In addition, a new fifth component, "Visible Leadership," was added to the 4-quadrant model and the Self-Assessment Tool. In the future, public health organizations should take an active leadership role in innovating and sustaining PM systems, ensuring they become accountable for producing outcomes, leveraging technology advances, and incorporating best practices from all stakeholders.

  6. Leveraging finances for public health system improvement: results from the Turning Point initiative.

    Science.gov (United States)

    Bekemeier, Betty; Riley, Catharine M; Berkowitz, Bobbie

    2007-01-01

    Reforming the public health infrastructure requires substantial system changes at the state level; state health agencies, however, often lack the resources and support for strategic planning and systemwide improvement. The Turning Point Initiative provided support for states to focus on large-scale system changes that resulted in increased funding for public health capacity and infrastructure development. Turning Point provides a test case for obtaining financial and institutional resources focused on systems change and infrastructure development-areas for which it has been historically difficult to obtain long-term support. The purpose of this exploratory, descriptive survey research was to enumerate the actual resources leveraged toward public health system improvement through the partnerships, planning, and implementation activities funded by the Robert Wood Johnson Foundation as a part of the Turning Point Initiative.

  7. Turning points and protective processes in the lives of people with chronic disabilities.

    Science.gov (United States)

    King, Gillian; Cathers, Tamzin; Brown, Elizabeth; Specht, Jacqueline A; Willoughby, Colleen; Polgar, Janice Miller; MacKinnon, Elizabeth; Smith, Linda K; Havens, Lisa

    2003-02-01

    In this qualitative study, the authors examined the nature of resilience in people with chronic disabilities. Fifteen people with disabilities identified the factors that helped or hindered them at major turning points, and the triggers and resolutions to these turning points. Turning points were emotionally compelling experiences and realizations that involved meaning acquired through the routes of belonging, doing, or understanding the self or the world. The major protective factors were social support, traits such as perseverance and determination, and spiritual beliefs. Three new protective processes were identified: replacing a loss with a gain (transcending), recognizing new things about oneself (self-understanding), and making decisions about relinquishing something in life (accommodating). These protective factors, processes, and ways in which people with disabilities draw sense and meaning in life have important implications for service delivery.

  8. The Turning Point for the Recent Acceleration of the Universe with a Cosmological Constant

    Directory of Open Access Journals (Sweden)

    Zhang T. X.

    2012-04-01

    Full Text Available The turning point and acceleration expansion of the universe are investigated according to the standard cosmological theory with a non-zero cosmological constant. Choosing the Hubble constant H 0 , the radius of the present universe R 0 , and the density parameter in matter Ω M , 0 as three independent parameters, we have analytically examined the other properties of the universe such as the density parameter in dark energy, the cosmologi- cal constant, the mass of the universe, the turning point redshift, the age of the present universe, and the time-dependent radius, expansion rate, velocity, and acceleration pa- rameter of the universe. It is shown that the turning point redshift is only dependent of the density parameter in matter, not explicitly on the Hubble constant and the radius of the present universe. The universe turned its expansion from past deceleration to recent acceleration at the moment when its size was about 3 / 5 of the present size if the density parameter in matter is about 0.3 (or the turning point redshift is 0.67. The expansion rate is very large in the early period and decreases with time to approach the Hubble constant at the present time. The expansion velocity exceeds the light speed in the early period. It decreases to the minimum at the turning point and then increases with time. The minimum and present expansion velocities are determined with the independent parameters. The solution of time-dependent radius shows the universe expands all the time. The universe with a larger present radius, smaller Hubble constant, and / or smaller density parameter in matter is elder. The universe with smaller density parameter in matter accelerates recently in a larger rate but less than unity.

  9. Turning point: the Robert Wood Johnson Foundation's effort to revitalize public health at the state level.

    Science.gov (United States)

    Hassmiller, Susan

    2002-01-01

    The Robert Wood Johnson (RWJ) Foundation initiated Turning Point in collaboration with the W.K. Kellogg Foundation (Kellogg) in 1997. The purpose of this major national initiative was to strengthen the public health infrastructure in the United States so that states, local communities, and their public health agencies might respond to the challenge to protect and improve the public's health in the 21st century. RWJ funded 21 states and Kellogg funded 43 communities to work together to create a new way of thinking about how health could be improved and who should be involved. Although the ultimate outcome was to improve health, both foundations expected diverse partnerships to work together to create strategic health improvement plans at both the community and state levels. The foundations funded a variety of strategies within those health improvement plans during an implementation phase. The premise in funding partnerships, as opposed to a single entity, was that effective public health systems would be developed best through a shared responsibility (including the private sector) for the health of a community.

  10. The turning points in the solution of n-queens problem using ...

    African Journals Online (AJOL)

    We also observed that, using a set of even and odd numbers, the odd number experience a turning point before the even numbers. The algorithm of the standard backtracking method was implemented in C programming language and, we used Microsoft Notepad as our output file to display the arrangement of the queens.

  11. 77 FR 25131 - Turning Point Solar LLC: Notice of Finding of No Significant Impact

    Science.gov (United States)

    2012-04-27

    ... monocrystalline photovoltaic panels mounted on fixed solar racking equipment and the construction of access roads... DEPARTMENT OF AGRICULTURE Rural Utilities Service Turning Point Solar LLC: Notice of Finding of No Significant Impact AGENCY: Rural Utilities Service, USDA. ACTION: Notice of Finding of No Significant Impact...

  12. 77 FR 4989 - Turning Point Solar LLC: Notice of Availability of an Environmental Assessment

    Science.gov (United States)

    2012-02-01

    ... monocrystalline photovoltaic panels mounted on fixed solar racking equipment and the construction of access roads... DEPARTMENT OF AGRICULTURE Rural Utilities Service Turning Point Solar LLC: Notice of Availability of an Environmental Assessment AGENCY: Rural Utilities Service, USDA. ACTION: Notice of Availability...

  13. A Systematic Approach to Process Evaluation in the Central Oklahoma Turning Point (COTP) Partnership

    Science.gov (United States)

    Tolma, Eleni L.; Cheney, Marshall K.; Chrislip, David D.; Blankenship, Derek; Troup, Pam; Hann, Neil

    2011-01-01

    Formation is an important stage of partnership development. Purpose: To describe the systematic approach to process evaluation of a Turning Point initiative in central Oklahoma during the formation stage. The nine-month collaborative effort aimed to develop an action plan to promote health. Methods: A sound planning framework was used in the…

  14. The Battle of Okinawa, 1945: Final Turning Point in the Pacific.

    Science.gov (United States)

    Tzeng, Megan

    2000-01-01

    Reviews the last major battle of World War II that occurred at Okinawa (Japan) in 1945. Explains why the Battle of Okinawa was the turning point in World War II. Includes two maps in the appendix and an annotated bibliography. (CMK)

  15. Theory of Single Point Incremental Forming

    DEFF Research Database (Denmark)

    Martins, P.A.F.; Bay, Niels; Skjødt, Martin

    2008-01-01

    This paper presents a closed-form theoretical analysis modelling the fundamentals of single point incremental forming and explaining the experimental and numerical results available in the literature for the past couple of years. The model is based on membrane analysis with bi-directional in-plan...

  16. Influence of acute normobaric hypoxia on physiological variables and lactate turn point determination in trained men.

    Science.gov (United States)

    Ofner, Michael; Wonisch, Manfred; Frei, Mario; Tschakert, Gerhard; Domej, Wolfgang; Kröpfl, Julia M; Hofmann, Peter

    2014-12-01

    The goal of this study is to evaluate the response of physiological variables to acute normobaric hypoxia compared to normoxia and its influence on the lactate turn point determination according to the three-phase model of energy supply (Phase I: metabolically balanced at muscular level; Phase II: metabolically balanced at systemic level; Phase III: not metabolically balanced) during maximal incremental exercise. Ten physically active (VO2max 3.9 [0.49] l·min(-1)), healthy men (mean age [SD]: 25.3 [4.6] yrs.), participated in the study. All participants performed two maximal cycle ergometric exercise tests under normoxic as well as hypoxic conditions (FiO2 = 14%). Blood lactate concentration, heart rate, gas exchange data, and power output at maximum and the first and the second lactate turn point (LTP1, LTP2), the heart rate turn point (HRTP) and the first and the second ventilatory turn point (VETP1, VETP2) were determined. Since in normobaric hypoxia absolute power output (P) was reduced at all reference points (max: 314 / 274 W; LTP2: 218 / 184 W; LTP1: 110 / 96 W), as well as VO2max (max: 3.90 / 3.23 l·min(-1); LTP2: 2.90 / 2.43 l·min(-1); LTP1: 1.66 / 1.52 l·min(-1)), percentages of Pmax at LTP1, LTP2, HRTP and VETP1, VETP2 were almost identical for hypoxic as well as normoxic conditions. Heart rate was significantly reduced at Pmax in hypoxia (max: 190 / 185 bpm), but no significant differences were found at submaximal control points. Blood lactate concentration was not different at maximum, and all reference points in both conditions. Respiratory exchange ratio (RER) (max: 1.28 / 1.08; LTP2: 1.13 / 0.98) and ventilatory equivalents for O2 (max: 43.4 / 34.0; LTP2: 32.1 / 25.4) and CO2 (max: 34.1 / 31.6; LTP2: 29.1 / 26.1) were significantly higher at some reference points in hypoxia. Significant correlations were found between LTP1 and VETP1 (r = 0.778; p better the performance of the athletes the higher is the effect of hypoxiaThe HRTP and LTP2 are

  17. Taking a historical turn: possible points of connection between social pyschology and history.

    Science.gov (United States)

    Knights, Mark

    2012-12-01

    The article confronts methodological differences between (and among) social psychologists and historians about how far the social psychologist should be interested only in contemporary or very recent history and how far general conclusions can be drawn about human behaviour across time and space. The article suggests that social psychology need not be present-centric and might take different forms of a 'historical turn'. In turn, it is suggested, historians can benefit from approaches developed by social psychologists. Seven possible points of connection with the discipline of history are put forward in the hope of fostering future collaborations. These are: the nature of modernity; collective memory and the uses of the past; political discourse and ideologies; partisanship; the public sphere; stereotypes; and languages and images. Indeed, just as they can encourage closer collaboration between historians and social psychologists, these themes might also open a wider inter-disciplinary discussion with anthropologists, sociologists, literary scholars, art historians and scholars of political discourse.

  18. Local Scaling Properties and Market Turning Points at Prague Stock Exchange

    Czech Academy of Sciences Publication Activity Database

    Krištoufek, Ladislav

    2010-01-01

    Roč. 41, č. 6 (2010), s. 1001-1014 ISSN 0587-4254 R&D Projects: GA ČR GA402/09/0965; GA ČR GD402/09/H045 Grant - others:GA UK(CZ) 118310 Institutional research plan: CEZ:AV0Z10750506 Keywords : scaling * Hurst exponent * extreme events Subject RIV: AH - Economics Impact factor: 0.671, year: 2010 http://library.utia.cas.cz/separaty/2010/E/kristoufek-local scaling properties and market turning points at prague stock exchange.pdf

  19. Turning points in physics, a series of lectures given at Oxford University in Trinity Term 1958

    CERN Document Server

    Blin-Stoyle, Roger John; Mendelssohn, Kurt; Temple, G; Waismann, F; Wilkinson, Denys Haigh; De Boer, J; Brinkman, H; Casimir, H B G

    1959-01-01

    Turning Points in Physics is a series of 1958 lectures presented at the Oxford University in Trinity Term. This six-chapter book highlights the interplay between assumptions, theories, and experimental discoveries in physics. The first chapter provides a brief introduction to the physical theory and field physics. The following two chapters cover the basic principles of quantum nature of matter and radiation, as well as the introduction of the probability concept in the field physics. The discussion then shifts to the theory of relativity and the fundamentals of cause and effect. The last chap

  20. Surface finish in ultra-precision diamond turning of single-crystal silicon

    Science.gov (United States)

    Ayomoh, M.; Abou-El-Hossein, K.

    2015-10-01

    Silicon is an optical material widely used in the production of infrared optics. However, silicon as a brittle material exhibits some difficulties when ultra-precision machined by mono-crystalline single point diamond. Finish turning of silicon with mono- crystalline diamond inserts results in accelerated tool wear rates if the right combination of the machining parameters is not properly selected. In this study, we conducted a series of machining tests on an ultra-high precision machine tool using finish turning conditions when using mono-crystalline diamond inserts with negative rake angle and relatively big nose radius. The study yields some recommendations on the best combination of machining parameters that will result in maximum material removal rates with smallest possible surface finish. In this work, standard non-controlled waviness diamond inserts having nose radius of about 1.5 mm, rake angle of negative 25°, and clearance angle of 5° were used to produce flat surfaces on silicon disk. From the results, it has been established that feed rate has the most influential effect followed by the depth of cut and cutting speed.

  1. Streaming instabilities of a non-neutral plasma with turning points

    International Nuclear Information System (INIS)

    Turner, L.; Finn, J.M.

    1995-01-01

    Streaming instabilities of a reflexing beam in a slab model of a beam Penning trap or an inertial electrostatic confinement device are studied. Particles may have turning points that may be between the walls. Linear theory is developed for the case in which the self-field cancels the external potential. If the electric field perturbation is odd about the center, these two-stream modes couple the slow waves on the two beams. Even modes consist of two classes: a class of two-stream modes and another class of complex-frequency modes, coupling the slow and fast waves on the same beam. The latter are unstable over a larger range than the two-stream modes. Thermal spread is stabilizing only when the thermal and streaming velocities are comparable. Numerical results for the general class of equilibria show both two-stream-like modes and oscillating modes

  2. Revealing turning points in ecosystem functioning over the Northern Eurasian agricultural frontier

    DEFF Research Database (Denmark)

    Horion, Stéphanie Marie Anne F; Prishchepov, Alexander; Verbesselt, Jan

    2016-01-01

    The collapse of the Soviet Union in 1991 has been a turning point in the World history that left a unique footprint on the Northern Eurasian ecosystems. Conducting large scale mapping of environmental change and separating between naturogenic and anthropogenic drivers is a difficult endeavor...... in such highly complex systems. In this research a piece-wise linear regression method was used for breakpoint detection in Rain-Use Efficiency (RUE) time series and a classification of ecosystem response types was produced. Supported by earth observation data, field data and expert knowledge, this study...... in the Volgograd region, and to increased salinization and increased grazing intensity around Lake Balkhash. The ecosystem-state assessment method introduced here proved to be a valuable support that highlighted hotspots of potentially altered ecosystems and allowed for disentangling human from climatic...

  3. Nitrate transport and supply limitations quantified using high-frequency stream monitoring and turning point analysis

    Science.gov (United States)

    Jones, Christopher S.; Wang, Bo; Schilling, Keith E.; Chan, Kung-sik

    2017-06-01

    Agricultural landscapes often leak inorganic nitrogen to the stream network, usually in the form of nitrate-nitrite (NOx-N), degrading downstream water quality on both the local and regional scales. While the spatial distribution of nitrate sources has been delineated in many watersheds, less is known about the complicated temporal dynamics that drive stream NOx-N because traditional methods of stream grab sampling are often conducted at a low frequency. Deployment of accurate real-time, continuous measurement devices that have been developed in recent years enables high-frequency sampling that provides detailed information on the concentration-discharge relation and the timing of NOx-N delivery to streams. We aggregated 15-min interval NOx-N and discharge data over a nine-year period into daily averages and then used robust statistical methods to identify how the discharge regime within an artificially-drained agricultural watershed reflected catchment hydrology and NOx-N delivery pathways. We then quantified how transport and supply limitations varied from year-to-year and how dependence of these limitations varied with climate, especially drought. Our results show NOx-N concentrations increased linearly with discharge up to an average "turning point" of 1.42 mm of area-normalized discharge, after which concentrations decline with increasing discharge. We estimate transport and supply limitations to govern 57 and 43 percent, respectively, of the NOx-N flux over the nine-year period. Drought effects on the NOx-N flux linger for multiple years and this is reflected in a greater tendency toward supply limitations in the three years following drought. How the turning point varies with climate may aid in prediction of NOx-N loading in future climate regimes.

  4. Turning points towards sustainability: integrative science and policy for novel (but real landscape futures

    Directory of Open Access Journals (Sweden)

    David J. Brunckhorst

    2004-09-01

    Full Text Available Non-metropolitan landscapes are the major theatre of interactions where large-scale alteration occurs precipitated by local to global forces of economic, social and environmental change. However, these regional landscape effects are critical also to local natural resource and social sustainability, ecosystem health through to larger scales of biospheric functioning. The institutions contributing pressures and responses consequently shape future landscapes and in turn influence how social systems, resource users, governments and policy makers perceive those landscapes and their future. These are, in essence, complex social-ecological systems intertwined in a multitude of ways at many spatial scales across time. Over time, the cycles of complex social-ecological systems also reach crossroads, which might be crisis points at which future options are no longer available (possibly because of resource degradation or loss, or turning points where opportunities arise when it is easier to change direction towards more sustainable activities. This paper provides some examples of interdisciplinary research that has provided a holistic integration through close engagement with residents and communities or through deliberately implementing integrative high-risk ‘on-ground’ experimental models to ‘learn by doing’. In the final analysis, each project has characteristically, however, sought to integrate through spatial (if not temporal synthesis, policy analysis and (new or changed institutional arrangements that are relevant locally and corporately, as well as at broader levels of government and geography. This has provided transferable outcomes that can contribute real options and adaptive capacity for suitable positive futures.

  5. The Nature of Child-Adult Interaction. From Turn-Taking to Understanding Pointing and Use of Pointing Gestures

    Directory of Open Access Journals (Sweden)

    Białek Arkadiusz

    2014-08-01

    Full Text Available Analyses of interactions between an adult and a one-year-old child are often connected with studying early communicative competences, e.g. the child’s participation in turn-taking sequences, in joint attention, and use of pointing gestures. Infants’ communicative behaviors were studied using a structured observational measure - the Early Social Communication Scales (Mundy et al., 2003 in a study of 358 12-month-old children. An exploratory factor analysis revealed: (i a distinction between the categories of initiation and response among the behaviors displayed, (ii simple and complex behavior categories occurring; (iii the presence within one factor of behaviors fulfilling various functions (e.g. requesting and sharing interest. An analysis of the results showed that communicative competences can be classified according to their level and ignoring their function, and made it possible to suggest modifications to the way in which behaviors are coded on the ESCS and to complement the procedure of studying early communicative competences.

  6. Making the case: leveraging resources toward public health system improvement in Turning Point states.

    Science.gov (United States)

    Bekemeier, Betty; Riley, Catharine M; Padgett, Stephen M; Berkowitz, Bobbie

    2007-01-01

    Leveraging funds to sustain the efforts of a grant-funded initiative is often an explicit, or implicit, expectation in philanthropy. However, the magnitude of funds leveraged and the factors that facilitate success in leveraging are rarely researched. An example of one of these grant-funded initiatives is the National Turning Point Initiative. Twenty-one states received funding from The Robert Wood Johnson Foundation as part of this initiative to establish and implement strategic goals for achieving significant statewide public health system improvement through diverse, cross-sector partnerships. Leaders from 17 of these 21 states participated in a two-phased study regarding the leveraging of additional funds for their public health infrastructure improvement activities. This article reports on the second phase of the study. In this phase, key informant interviews were conducted to examine how leveraging of resources occurred as part of this large national initiative. Findings indicate that the combination of a comprehensive planning process and a broad-based partnership was crucial in securing resources to expand their efforts. The ability to strategically respond to unexpected events and opportunities also helped states use their plans and partnerships to "make the case" for additional resources to improve their public health infrastructure.

  7. Is educational achievement a turning point for incarcerated delinquents across race and sex?

    Science.gov (United States)

    Blomberg, Thomas G; Bales, William D; Piquero, Alex R

    2012-02-01

    Research has linked the role of education to delinquency, but much of the focus has been on general population samples and with little attention to demographic differences. Employing a cumulative disadvantage framework that integrates elements of informal social control and labeling theories, this article examines whether academic achievement serves as a positive turning point and re-directs juvenile delinquents away from subsequent offending. Attention is also given to race/sex contingencies. Using a sample of 4,147 delinquents released from Florida correctional institutions (86% male, 57% non-White, average age at release = 16.8 years), propensity score analysis yielded two findings: youth with above average academic achievement while incarcerated were significantly more likely to return to school post-release, and youth with above average attendance in public school were significantly less likely to be re-arrested in the 1-year post-release period. While the academic gains were pronounced among African-American males, the preventive effects of school attendance are similar across race and sex, suggesting that education can be a part of a larger prevention effort that assists juvenile delinquents in successful community re-entry.

  8. Turning points in nonlinear business cycle theories, financial crisis and the 2007-2008 downturn.

    Science.gov (United States)

    Dore, Mohammed H I; Singh, Ragiv G

    2009-10-01

    This paper reviews three nonlinear dynamical business cycle theories of which only one (The Goodwin model) reflects the stylized facts of observed business cycles and has a plausible turning point mechanism. The paper then examines the US (and now global) financial crisis of 2008 and the accompanying downturn in the US. The paper argues that a skewed income distribution could not sustain effective demand and that over the 2001-2006 expansion demand was maintained through massive amounts of credit, with more than 50 percent of sales in the US being maintained through credit. A vector autoregression model confirms the crucial role played by credit. However legislative changes that dismantled the restrictions placed on the financial sector after the crash of 1929 and the consequent structural changes in the financial sector after 1980 enabled the growth of new debt instruments and credit. But overexpansion of credit when profits and house prices were declining in 2005/06 led to a nonlinear shift due to a new realization of the poor quality of some of this debt, namely mortgage backed securities. Bankruptcies, followed by retrenchment at the banks, then led to the bursting of the credit bubble, with the possibility of a severe recession.

  9. 1996, a turning point in the evolution of the EDF with good financial results

    International Nuclear Information System (INIS)

    1997-03-01

    This conference held on March 1997 presents the financial results obtained in 1996 by French Electricity Company EDF (Electricite de France). This year represented a turning point because essential landmarks were established in 1996. An european directive has been adopted in 1996 defining the framework in which european electricity market will function as well as the rules for its opening to competition. Discussions with the trade unions were conducted at the beginning of 1997 and a social agreement aiming at the amelioration of services and hiring of 11,000 to 15,000 young people in the next three years. Finally, a new contract of enterprise with the state has been discussed and approved in March 5, 1997, which redefined the place and the role of EDF in the French economy, in the new stage of electricity market started by the opening to competition. The document contains the following 8 chapters: 1. Financial results and enterprise management; 2. Institutional frame and the relation with the state; 3. Development in France; 4. International development; 5. Alliances, partnerships and cooperation; 6. Management, social and human resources; 7. Environment; 8. Technical results

  10. Postural strategies and sensory integration: no turning point between childhood and adolescence.

    Directory of Open Access Journals (Sweden)

    Sophie Mallau

    reweighting for postural strategies as assessed by very slow support oscillations presents a linear development without any qualitative turning point between childhood and adolescence.

  11. Postural strategies and sensory integration: no turning point between childhood and adolescence.

    Science.gov (United States)

    Mallau, Sophie; Vaugoyeau, Marianne; Assaiante, Christine

    2010-09-29

    strategies as assessed by very slow support oscillations presents a linear development without any qualitative turning point between childhood and adolescence.

  12. Improving the Patron Experience: Sterling Memorial Library's Single Service Point

    Science.gov (United States)

    Sider, Laura Galas

    2016-01-01

    This article describes the planning process and implementation of a single service point at Yale University's Sterling Memorial Library. While much recent scholarship on single service points (SSPs) has focused on the virtues or hazards of eliminating reference desks in libraries nationwide, this essay explores the ways in which single service…

  13. Transistors - From Point Contact to Single Electron

    Indian Academy of Sciences (India)

    development of the energy band theory of solids by Wilson. ... Davydov developed bis theory independently. All these theories had shortcomings as pointed out by Sab. The correct theory of metal-semiconductor diodes based on thermionic emission of majority carriers .... watches and other portable consumer applications.

  14. Single and multispecies reference points for Baltic fish stocks

    DEFF Research Database (Denmark)

    Gislason, Henrik

    1999-01-01

    Single and multispecies models are used to examine the effect of species interaction on biological reference points for cod, herring, and sprat in the Baltic. The results demonstrate that reference points are different in single and multispecies contexts. Reference points for fishing mortality...... based on single-species yield and SSB calculations are difficult to use when natural mortality depends on the absolute abundance of the predators and their alternative prey. Reference points based on maximizing total yield from the system may lead to impractical results when species interact...... reference points. Management advice based on biomass reference points will also differ. In the single species situation the combinations of cod and pelagic fishing effort for which the equilibrium spawning- stock biomass of the three species is above the biomass reference points forms a rectangular area...

  15. Are Mentor Relationships Helping Organizations? An Exploration of Developing Mentee-Mentor-Organizational Identifications Using Turning Point Analysis.

    Science.gov (United States)

    Bullis, Connie; Bach, Betsy Wackernagel

    1989-01-01

    Examines developing mentor relationships and the association between mentor relationships and individual-organizational relationships. Indicates that many turning points occur later than proposed in broad-phase models of mentor relationship development. Finds that mentor relationships should not be assumed to benefit organizations. (SR)

  16. 76 FR 37313 - Turning Point Solar LLC; Notice of Intent To Hold a Public Scoping Meeting and Prepare an...

    Science.gov (United States)

    2011-06-27

    ... and the construction of access roads, a powerhouse, transmission improvements, and other supporting... DEPARTMENT OF AGRICULTURE Rural Utilities Service Turning Point Solar LLC; Notice of Intent To Hold a Public Scoping Meeting and Prepare an Environmental Assessment AGENCY: Rural Utilities Service...

  17. Systematic investigation on the turning point of over-inflammation to immunosuppression in CLP mice model and their characteristics.

    Science.gov (United States)

    Deng, Dongmei; Li, Xiaoli; Liu, Chao; Zhai, Zhaoxia; Li, Bin; Kuang, Mei; Li, Pan; Shang, Shenglan; Song, Yi; Cen, Yanyan; Qin, Rongxin; Lu, Yonglin; Zhao, Yibo; Cheng, Hao; Zheng, Jiang; Zhou, Hong

    2017-01-01

    Immunosuppression is involved in refractory innate and adaptive immune responses and is considered to be the predominant driving force for mortality in sepsis. The cecal ligation and puncture (CLP) model is regarded as a golden standard model for sepsis study, but the turning point of over-inflammation to immunosuppression was reported differently. Herein, systematic investigation on the turning point of over-inflammation to immunosuppression in CLP mice model was carried out. The results showed only the mortality of mice challenged with of Pseudomonas aeruginosa on Day 1 not other days after the surgery was higher than that of other mice with Sham surgery, suggesting Day 1 after the CLP surgery might be the turning point. There was very low mortality even without death in Sham mice but the mortality was 80% after mice were challenged with 2.5×10 7 , 5.0×10 6 and 1.0×10 6 CFU/10g of Pseudomonas aeruginosa, further demonstrating Day 1 after the CLP surgery was the turning point. And, CLP mice presented low levels of pro-inflammatory and anti-inflammatory cytokines, and high bacterial loads on Day 1. Additionally, the amounts and proportion of blood cells and monocytes significantly changed, too. In conclusion, Day 1 after the CLP surgery was the turning point of over-inflammation to immunosuppression, and low levels of cytokines and high bacterial loads were the characteristics of this model on Day 1, which is significant for pharmacological investigation on sepsis. Copyright © 2016 Elsevier B.V. All rights reserved.

  18. Program computes single-point failures in critical system designs

    Science.gov (United States)

    Brown, W. R.

    1967-01-01

    Computer program analyzes the designs of critical systems that will either prove the design is free of single-point failures or detect each member of the population of single-point failures inherent in a system design. This program should find application in the checkout of redundant circuits and digital systems.

  19. Creating Helical Tool Paths for Single Point Incremental Forming

    DEFF Research Database (Denmark)

    Skjødt, Martin; Hancock, Michael H.; Bay, Niels

    2007-01-01

    Single point incremental forming (SPIF) is a relatively new sheet forming process. A sheet is clamped in a rig and formed incrementally using a rotating single point tool in the form of a rod with a spherical end. The process is often performed on a CNC milling machine and the tool movement...

  20. Assessment of single-turn extraction for a superconducting separated-sector cyclotron

    Directory of Open Access Journals (Sweden)

    J.-W. Kim

    1999-04-01

    Full Text Available We have studied the beam dynamics in a high field separated-sector cyclotron to establish conditions required to achieve single-turn extraction. Extraction efficiency above 99% is aimed to avoid beam-induced damages. A sufficient last-turn separation and a preservation of beam quality throughout the acceleration are the prerequisites. The last-turn separation can be enhanced with the orbital precession induced by an off-centering injection as in existent lower field separated-sector cyclotrons. The beam qualities, on the other hand, are affected by the resonances traversed or approached during the acceleration. Acceleration of light nuclei to the energies of 300–400 MeV/u was especially disturbing because of the broadening of radial beamwidth upon crossing the ν_{r}=3/2 resonance. Tolerance to the third harmonic gradient field, which causes the resonance in lowest order, is set to be 0.1 G/cm. The integer resonance ν_{z}=1 can be avoided with a proper design of the yoke. The longitudinal space charge forces were also investigated to estimate the intensity limits determined by the energy spreads of beam assuming simplified charge distributions. Moreover, beam preparations for injection matching are described in view of reducing the beam losses into the extraction elements.

  1. SOCIAL POLICY AND STRUCTURAL HETEROGENEITY IN LATIN AMERICA: THE TURNING POINT OF THE 21ST CENTURY

    Directory of Open Access Journals (Sweden)

    Lena Lavinas

    2017-12-01

    Full Text Available ABSTRACT This article addresses the complementarity between social policy and pro-growth macroeconomic policies, which turned redistribution into a crucial issue to consolidate market societies through the expansion of demand. It focuses on the recent economic history of Latin America, marked by the emergence of new conceptual paradigms so as to grasp the singularities of the region´s development. Three questions are then raised: i which social inclusion model distinguishes the new period of economic growth led by the so called social-developmentalist strategies? ii what role is assigned to the social protection system and to social policies in general in this context? iii which mechanisms enabled the transition towards a mass-consumption society? Brazil will serve as a case study.

  2. The complexity of interior point methods for solving discounted turn-based stochastic games

    DEFF Research Database (Denmark)

    Hansen, Thomas Dueholm; Ibsen-Jensen, Rasmus

    2013-01-01

    We study the problem of solving discounted, two player, turn based, stochastic games (2TBSGs). Jurdziński and Savani showed that in the case of deterministic games the problem can be reduced to solving P-matrix linear complementarity problems (LCPs). We show that the same reduction also works...... in time O((1 + κ)n 3.5 L) and O(−δθn4logϵ−1) , respectively, when applied to an LCP defined by an n ×n matrix M that can be described with L bits, and where the potential reduction algorithm returns an ε-optimal solution. The parameters κ, δ, and θ depend on the matrix M. We show that for 2TBSGs with n...

  3. Trajectories of Affective States in Adolescent Hockey Players: Turning Point and Motivational Antecedents

    Science.gov (United States)

    Gaudreau, Patrick; Amiot, Catherine E.; Vallerand, Robert J.

    2009-01-01

    This study examined longitudinal trajectories of positive and negative affective states with a sample of 265 adolescent elite hockey players followed across 3 measurement points during the 1st 11 weeks of a season. Latent class growth modeling, incorporating a time-varying covariate and a series of predictors assessed at the onset of the season,…

  4. Point defects and electric compensation in gallium arsenide single crystals

    International Nuclear Information System (INIS)

    Kretzer, Ulrich

    2007-01-01

    In the present thesis the point-defect budget of gallium arsenide single crystals with different dopings is studied. It is shown, in which way the concentration of the single point defects depende on the concentration of the dopants, the stoichiometry deviation, and the position of the Fermi level. For this serve the results of the measurement-technical characterization of a large number of samples, in the fabrication of which these parameters were directedly varied. The main topic of this thesis lies in the development of models, which allow a quantitative description of the experimentally studied electrical and optical properties of gallium arsenide single crystals starting from the point-defect concentrations. Because from point defects charge carriers can be set free, their concentration determines essentially the charge-carrier concentration in the bands. In the ionized state point defects act as scattering centers for free charge carriers and influence by this the drift mobility of the charge carriers. A thermodynamic modeling of the point-defect formation yields statements on the equilibrium concentrations of the point defects in dependence on dopant concentration and stoichiometry deviation. It is show that the electrical properties of the crystals observed at room temperature result from the kinetic suppression of processes, via which the adjustment of a thermodynamic equilibrium between the point defects is mediated [de

  5. Bernhard Riemann 1826-1866 Turning Points in the Conception of Mathematics

    CERN Document Server

    Laugwitz, Detlef

    2008-01-01

    The name of Bernard Riemann is well known to mathematicians and physicists around the world. College students encounter the Riemann integral early in their studies. Real and complex function theories are founded on Riemann’s work. Einstein’s theory of gravitation would be unthinkable without Riemannian geometry. In number theory, Riemann’s famous conjecture stands as one of the classic challenges to the best mathematical minds and continues to stimulate deep mathematical research. The name is indelibly stamped on the literature of mathematics and physics. This book, originally written in German and presented here in an English-language translation, examines Riemann’s scientific work from a single unifying perspective. Laugwitz describes Riemann’s development of a conceptual approach to mathematics at a time when conventional algorithmic thinking dictated that formulas and figures, rigid constructs, and transformations of terms were the only legitimate means of studying mathematical objects. David Hi...

  6. A turning point in the concept of justice: from Adam Smith to John Stuart Mill

    Directory of Open Access Journals (Sweden)

    Estrella Trincado Aznar

    2012-01-01

    Full Text Available Classical economists, John Stuart Mill included, based their theories on Adam Smith’s system. At some point, they labelled it as a "utilitarian" theory. However, Smith was non-utilitarian, perhaps even anti-utilitarian. One of the most amazing differences between classical economics versus Smithian theory consists of their concept of justice. Classical economics were based on a utilitarian concept; Smith criticizes the concept of utilitarian justice. Utility being a subjective picture, classical economists find it more difficult to draw limits to state intervention than Smith does. This paper compares Smith’s and John Stuart Mill’s concept of justice when they make the case for land tenure. Mill admits that society cannot properly be said to owe anything to the poor. However, not arguing from 'abstract rights,' but from 'utility' understood in its largest sense, Mill defended the nationalization of land. Mill was unable to draw any limits to state intervention. Conversely, Smith defended that justice is not a utilitarian concept. In this case, limits to state intervention are more easily drawn.

  7. A turning point in the concept of justice: from Adam Smith to John Stuart Mill

    Directory of Open Access Journals (Sweden)

    Estrella Trincado Aznar

    2015-07-01

    Full Text Available Classical economists, John Stuart Mill included, based their theories on Adam Smith’s system. At some point, they labelled it as a "utilitarian" theory. However, Smith was non-utilitarian, perhaps even anti-utilitarian. One of the most amazing differences between classical economics versus Smithian theory consists of their concept of justice. Classical economics were based on a utilitarian concept; Smith criticizes the concept of utilitarian justice. Utility being a subjective picture, classical economists find it more difficult to draw limits to state intervention than Smith does. This paper compares Smith’s and John Stuart Mill’s concept of justice when they make the case for land tenure. Mill admits that society cannot properly be said to owe anything to the poor. However, not arguing from 'abstract rights,' but from 'utility' understood in its largest sense, Mill defended the nationalization of land. Mill was unable to draw any limits to state intervention. Conversely, Smith defended that justice is not a utilitarian concept. In this case, limits to state intervention are more easily drawn.

  8. Turning point or selection? The effect of rustication on subsequent health for the Chinese Cultural Revolution cohort.

    Science.gov (United States)

    Fan, Wen

    2016-05-01

    During the Chinese Cultural Revolution (1966-76), Chairman Mao sent 17 million urban youth to rural areas to be "reeducated." These "sent-down" youth spent years working alongside peasants, enduring inadequate diets, shelter and medical attention. What were the consequences for subsequent health? Was there a benefit to individuals in the leading or trailing edges of this cohort? Was this a fundamental turning point or were selection process at work? Drawing on the 1994 State and Life Chances in Urban China Survey, I find the health disadvantage at midlife is mostly borne by members of the trailing-edge sub-cohort who lived in the countryside for more than five years. Results from propensity-score analysis indicate a selection process: those who suffered most came from disadvantaged backgrounds. Life chances following the rusticates' return home, however, either do not differ from those who stayed in cities or do not relate to health, refuting the turning-point view, at least in terms of midlife health. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. Single-point incremental forming and formability-failure diagrams

    DEFF Research Database (Denmark)

    Silva, M.B.; Skjødt, Martin; Atkins, A.G.

    2008-01-01

    In a recent work [1], the authors constructed a closed-form analytical model that is capable of dealing with the fundamentals of single point incremental forming and explaining the experimental and numerical results published in the literature over the past couple of years. The model is based on ...

  10. Transistors-From Point Contact to Single Electron

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 2; Issue 12. Transistors – From Point Contact to Single Electron. D N Bose. General Article Volume 2 Issue 12 December 1997 pp 39-54. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/002/12/0039-0054 ...

  11. Revisiting the fundamentals of single point incremental forming by

    DEFF Research Database (Denmark)

    Silva, Beatriz; Skjødt, Martin; Martins, Paulo A.F.

    2008-01-01

    Knowledge of the physics behind the fracture of material at the transition between the inclined wall and the corner radius of the sheet is of great importance for understanding the fundamentals of single point incremental forming (SPIF). How the material fractures, what is the state of strain and...

  12. Common fixed points of single-valued and multivalued maps

    Directory of Open Access Journals (Sweden)

    Yicheng Liu

    2005-01-01

    Full Text Available We define a new property which contains the property (EA for a hybrid pair of single- and multivalued maps and give some new common fixed point theorems under hybrid contractive conditions. Our results extend previous ones. As an application, we give a partial answer to the problem raised by Singh and Mishra.

  13. Turning Point - March 1998

    Energy Technology Data Exchange (ETDEWEB)

    1998-03-01

    As a Motor Challenge Showcase Demonstration project partner, the Southeast Resource Recovery Facility in Long Beach, California, improved the overall efficiency of its operating systems enough to garner annual savings of$329,500. Other companies, such as Johnson& Johnson, have shown their commitment to excellence in energy by joining the Motor Challenge Excellence Partnership. Order your copy of the spring issue of the newsletter and discover how your organization can achieve significant energy savings by improving their motor systems.

  14. Laser-induced single point nanowelding of silver nanowires

    Energy Technology Data Exchange (ETDEWEB)

    Dai, Shuowei; Li, Qiang, E-mail: qiangli@zju.edu.cn; Liu, Guoping; Yang, Hangbo; Yang, Yuanqing; Zhao, Ding; Wang, Wei; Qiu, Min, E-mail: minqiu@zju.edu.cn [State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027 (China)

    2016-03-21

    Nanowelding of nanomaterials opens up an emerging set of applications in transparent conductors, thin-film solar cells, nanocatalysis, cancer therapy, and nanoscale patterning. Single point nanowelding (SPNW) is highly demanded for building complex nanostructures. In this letter, the precise control of SPNW of silver nanowires is explored in depth, where the nanowelding is laser-induced through the plasmonic resonance enhanced photothermal effect. It is shown that the illumination position is a critical factor for the nanowelding process. As an example of performance enhancement, output at wire end can be increased by 65% after welding for a plasmonic nanocoupler. Thus, single point nanowelding technique shows great potentials for high-performance electronic and photonic devices based on nanowires, such as nanoelectronic circuits and plasmonic nanodevices.

  15. Creating Helical Tool Paths for Single Point Incremental Forming

    DEFF Research Database (Denmark)

    Skjødt, Martin; Hancock, Michael H.; Bay, Niels

    2007-01-01

    Single point incremental forming (SPIF) is a relatively new sheet forming process. A sheet is clamped in a rig and formed incrementally using a rotating single point tool in the form of a rod with a spherical end. The process is often performed on a CNC milling machine and the tool movement...... is programed using CAM software intended for surface milling. Often the function called profile milling or contour milling is applied. Using this milling function the tool only has a continuous feed rate in two directions X and Y, which is the plane of the undeformed sheet. The feed in the vertical Z direction...... from the profile milling code and converts them into a helical tool path with continuous feed in all three directions. Using the helical tool path the scarring is removed, the part is otherwise unchanged and a major disadvantage of using milling software for SPIF is removed. The solution...

  16. 3D Point Cloud Reconstruction from Single Plenoptic Image

    Directory of Open Access Journals (Sweden)

    F. Murgia

    2016-06-01

    Full Text Available Novel plenoptic cameras sample the light field crossing the main camera lens. The information available in a plenoptic image must be processed, in order to create the depth map of the scene from a single camera shot. In this paper a novel algorithm, for the reconstruction of 3D point cloud of the scene from a single plenoptic image, taken with a consumer plenoptic camera, is proposed. Experimental analysis is conducted on several test images, and results are compared with state of the art methodologies. The results are very promising, as the quality of the 3D point cloud from plenoptic image, is comparable with the quality obtained with current non-plenoptic methodologies, that necessitate more than one image.

  17. Laser-induced single point nanowelding of silver nanowires

    International Nuclear Information System (INIS)

    Dai, Shuowei; Li, Qiang; Liu, Guoping; Yang, Hangbo; Yang, Yuanqing; Zhao, Ding; Wang, Wei; Qiu, Min

    2016-01-01

    Nanowelding of nanomaterials opens up an emerging set of applications in transparent conductors, thin-film solar cells, nanocatalysis, cancer therapy, and nanoscale patterning. Single point nanowelding (SPNW) is highly demanded for building complex nanostructures. In this letter, the precise control of SPNW of silver nanowires is explored in depth, where the nanowelding is laser-induced through the plasmonic resonance enhanced photothermal effect. It is shown that the illumination position is a critical factor for the nanowelding process. As an example of performance enhancement, output at wire end can be increased by 65% after welding for a plasmonic nanocoupler. Thus, single point nanowelding technique shows great potentials for high-performance electronic and photonic devices based on nanowires, such as nanoelectronic circuits and plasmonic nanodevices.

  18. ODMR of single point defects in silicon nanostructures

    Energy Technology Data Exchange (ETDEWEB)

    Bagraev, Nikolay; Danilovsky, Eduard; Gets, Dmitry; Klyachkin, Leonid; Kudryavtsev, Andrey; Kuzmin, Roman; Malyarenko, Anna [Ioffe Physical-Technical Institute, Polytekhnicheskaya st. 26, 194021 St. Petersburg (Russian Federation)

    2012-05-15

    We present the findings of the optically detected magnetic resonance technique (ODMR), which reveal single point defects in the ultra-narrow silicon quantum wells (Si-QW) confined by the superconductor {delta}-barriers. This technique allows the ODMR identification without application of an external cavity, as well as a high frequency source and recorder, and with measuring the transmission spectra within the frameworks of the excitonic normal-mode coupling caused by the microcavities embedded in the Si-QW plane. (copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  19. Testing single point incremental forming molds for thermoforming operations

    Science.gov (United States)

    Afonso, Daniel; de Sousa, Ricardo Alves; Torcato, Ricardo

    2016-10-01

    Low pressure polymer processing processes as thermoforming or rotational molding use much simpler molds then high pressure processes like injection. However, despite the low forces involved with the process, molds manufacturing for this operations is still a very material, energy and time consuming operation. The goal of the research is to develop and validate a method for manufacturing plastically formed sheets metal molds by single point incremental forming (SPIF) operation for thermoforming operation. Stewart platform based SPIF machines allow the forming of thick metal sheets, granting the required structural stiffness for the mold surface, and keeping the short lead time manufacture and low thermal inertia.

  20. Point defects in electron-irradiated oxide single crystals

    Energy Technology Data Exchange (ETDEWEB)

    Caulfield, K.J.; Cooper, R. [Univ. of Melbourne, Parkville, Victoria (Australia). Dept. of Chemistry; Boas, J.F. [Australian Radiation Lab., Yallambie, Victoria (Australia)

    1995-04-01

    Point defects have been produced in CaO, MgO, and {alpha}-Al{sub 2}O{sub 3} single crystals by electron irradiation, and thresholds for atomic displacement have been measured using time-resolved luminescence spectroscopy. Oxygen displacement energies of approximately 50 eV have been determined; however, a temperature-dependent threshold observed for an emission band in MgO may arise from a magnesium displacement. A 300-nm emission in {alpha}-Al{sub 2}O{sub 3} may be due to an F-center transition. Studies of radiative recombination kinetics are consistent with an electron-detrapping model.

  1. Failure mechanisms in single-point incremental forming of metals

    DEFF Research Database (Denmark)

    Silva, Maria B.; Nielsen, Peter Søe; Bay, Niels

    2011-01-01

    The last years saw the development of two different views on how failure develops in single-point incremental forming (SPIF). Today, researchers are split between those claiming that fracture is always preceded by necking and those considering that fracture occurs with suppression of necking. Eac...... and involves independent determination of formability limits by necking and fracture using tensile and hydraulic bulge tests in conjunction with SPIF of benchmark shapes under laboratory conditions.......The last years saw the development of two different views on how failure develops in single-point incremental forming (SPIF). Today, researchers are split between those claiming that fracture is always preceded by necking and those considering that fracture occurs with suppression of necking. Each...... on formability limits and development of fracture. The unified view conciliates the aforementioned different explanations on the role of necking in fracture and is consistent with the experimental observations that have been reported in the past years. The work is performed on aluminium AA1050-H111 sheets...

  2. Managing Contextual Complexity in an Experiential Learning Course: A Dynamic Systems Approach through the Identification of Turning Points in Students' Emotional Trajectories.

    Science.gov (United States)

    Nogueiras, Gloria; Kunnen, E Saskia; Iborra, Alejandro

    2017-01-01

    This study adopts a dynamic systems approach to investigate how individuals successfully manage contextual complexity. To that end, we tracked individuals' emotional trajectories during a challenging training course, seeking qualitative changes-turning points-and we tested their relationship with the perceived complexity of the training. The research context was a 5-day higher education course based on process-oriented experiential learning, and the sample consisted of 17 students. The students used a five-point Likert scale to rate the intensity of 16 emotions and the complexity of the training on 8 measurement points. Monte Carlo permutation tests enabled to identify 30 turning points in the 272 emotional trajectories analyzed (17 students * 16 emotions each). 83% of the turning points indicated a change of pattern in the emotional trajectories that consisted of: (a) increasingly intense positive emotions or (b) decreasingly intense negative emotions. These turning points also coincided with particularly complex periods in the training as perceived by the participants ( p = 0.003, and p = 0.001 respectively). The relationship between positively-trended turning points in the students' emotional trajectories and the complexity of the training may be interpreted as evidence of a successful management of the cognitive conflict arising from the clash between the students' prior ways of meaning-making and the challenging demands of the training. One of the strengths of this study is that it provides a relatively simple procedure for identifying turning points in developmental trajectories, which can be applied to various longitudinal experiences that are very common in educational and developmental contexts. Additionally, the findings contribute to sustaining that the assumption that complex contextual demands lead unfailingly to individuals' learning is incomplete. Instead, it is how individuals manage complexity which may or may not lead to learning. Finally, this

  3. Optical Properties And Thermal Stability Of Single-Point Diamond-Machined Aluminum Alloys

    Science.gov (United States)

    Ogloza, A. A.; Decker, D. L.; Archibald, P. C.; O'Connor, D. A.; Bueltmann, E. R.

    1989-01-01

    This paper presents the results of diamond-turned surfaces of a wide range of aluminum alloys. The alloys machined included a sand-cast A201 alloy manufactured by Specialty Aluminum Inc., conventionally extruded plate alloys 2024, 3003, 5052, 6061, 7075, and for comparison as a best and worst case possible a high-purity aluminum single crystal, and tooling plate. The surfaces were obtained by diamond single-point machining using an interferometrically controlled two-axis, air-bearing lathe. The effect of tool-rake angle and machining fluid on surface quality is examined. Surface characterization was performed by Nomarski microscopy and noncontact optical surface profilometry. The optical properties measured included absolute reflectance at 3.8 μm, total integrated scatter at 752.5 nm, and bidirectional reflection distribution function measurements at 632.8 nm. The dimensional stability of the aluminum alloys subject to thermal cycling is examined.

  4. Managing Contextual Complexity in an Experiential Learning Course: A Dynamic Systems Approach through the Identification of Turning Points in Students' Emotional Trajectories

    Directory of Open Access Journals (Sweden)

    Gloria Nogueiras

    2017-05-01

    Full Text Available This study adopts a dynamic systems approach to investigate how individuals successfully manage contextual complexity. To that end, we tracked individuals' emotional trajectories during a challenging training course, seeking qualitative changes–turning points—and we tested their relationship with the perceived complexity of the training. The research context was a 5-day higher education course based on process-oriented experiential learning, and the sample consisted of 17 students. The students used a five-point Likert scale to rate the intensity of 16 emotions and the complexity of the training on 8 measurement points. Monte Carlo permutation tests enabled to identify 30 turning points in the 272 emotional trajectories analyzed (17 students * 16 emotions each. 83% of the turning points indicated a change of pattern in the emotional trajectories that consisted of: (a increasingly intense positive emotions or (b decreasingly intense negative emotions. These turning points also coincided with particularly complex periods in the training as perceived by the participants (p = 0.003, and p = 0.001 respectively. The relationship between positively-trended turning points in the students' emotional trajectories and the complexity of the training may be interpreted as evidence of a successful management of the cognitive conflict arising from the clash between the students' prior ways of meaning-making and the challenging demands of the training. One of the strengths of this study is that it provides a relatively simple procedure for identifying turning points in developmental trajectories, which can be applied to various longitudinal experiences that are very common in educational and developmental contexts. Additionally, the findings contribute to sustaining that the assumption that complex contextual demands lead unfailingly to individuals' learning is incomplete. Instead, it is how individuals manage complexity which may or may not lead to

  5. Securing Single Points of Compromise (SPoC)

    Energy Technology Data Exchange (ETDEWEB)

    Belangia, David Warren [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-06-25

    Securing the Single Points of Compromise that provide central services to the institution’s environment is paramount to success when trying to protect the business. (Fisk, 2014) Time Based Security mandates protection (erecting and ensuring effective controls) that last longer than the time to detect and react to a compromise. When enterprise protections fail, providing additional layered controls for these central services provides more time to detect and react. While guidance is readily available for securing the individual critical asset, protecting these assets as a group is not often discussed. Using best business practices to protect these resources as individual assets while leveraging holistic defenses for the group increases the opportunity to maximize protection time, allowing detection and reaction time for the SPoCs that is commensurate with the inherent risk of these centralized services.

  6. The Analysis of Forming Forces in Single Point Incremental Forming

    Directory of Open Access Journals (Sweden)

    Koh Kyung Hee

    2016-01-01

    Full Text Available Incremental forming is a process to produce sheet metal parts in quick. Because there is no need for dedicated dies and molds, this process is less cost and time spent. The purpose of this study is to investigate forming forces in single point incremental forming. Producing a cone frustum of aluminum is tested for forming forces. A dynamometer is used to collect forming forces and analyze them. These forces are compared with cutting forces upon producing same geometrical shapes of experimental parts. The forming forces in Z direction are 40 times larger than the machining forces. A spindle and its axis of a forming machine should be designed enough to withstand the forming forces.

  7. Code Single Point Positioning Using Nominal GNSS Constellations (Future Perception)

    Science.gov (United States)

    Farah, A. M. A.

    Global Navigation Satellite Systems (GNSS) have an endless number of applications in industry, science, military, transportation and recreation & sports. Two systems are currently in operation, namely GPS (the USA Global Positioning System) and GLONASS (the Russian GLObal NAvigation Satellite System), and a third is planned, the European satellite navigation system GALILEO. The potential performance improvements achievable through combining these systems could be significant and expectations are high. The need is inevitable to explore the future of positioning from different nominal constellations. In this research paper, Bernese 5.0 software could be modified to simulate and process GNSS observations from three different constellations (GPS, GLONASS and Galileo) using different combinations. This study presents results of code single point positioning for five stations using the three constellations and different combinations.

  8. Single Point Incremental Forming using a Dummy Sheet

    DEFF Research Database (Denmark)

    Skjødt, Martin; Silva, Beatriz; Bay, Niels

    2007-01-01

    A new version of single point incremental forming (SPIF) is presented. This version includes a dummy sheet on top of the work piece, thus forming two sheets instead of one. The dummy sheet, which is in contact with the rotating tool pin, is discarded after forming. The new set-up influences...... the process and furthermore offers a number of new possibilities for solving some of the problems appearing in SPIF. Investigations of the influence of dummy sheet on: formability, wear, surface quality and bulging of planar sides is done by forming to test shapes: a hyperboloid and a truncated pyramid....... The possible influence of friction between the two sheets is furthermore investigated. The results show that the use of a dummy sheet reduces wear of the work piece to almost zero, but also causes a decrease in formability. Bulging of the planar sides of the pyramid is reduced and surface roughness...

  9. Single supplier single retailer inventory model controlled by the reorder and shipping points with sharing information

    Science.gov (United States)

    Ho, Wen-Tsung; Hsiao, Yu-Cheng

    2012-04-01

    This study investigated the integrated stochastic inventory problem for a two-stage supply chain consisting of a single retailer and a single supplier. By using batch shipment policy, the expected total cost can be significantly reduced. An equally sized batch shipment model, controlled by both the reorder and shipping points, with sharing information by enterprise resource planning and radio frequency identification is constructed. The problem is solved optimally by the proposed algorithm that determines the economic lot size, the optimal batch sizes and number of batches. A numerical example is included to illustrate the algorithmic procedures and to prove that the model controlled both by the reorder and shipping points is superior to the classic model controlled only by the reorder point.

  10. TOWARDS COLLABORATION BETWEEN PUBLIC WELFARE AGENCIES AND MASS ENTERTAINMENT MEDIA TO BRING ABOUT A TURNING POINT STAGE IN THE LIVES OF BATTERED WOMEN

    Directory of Open Access Journals (Sweden)

    Nourit Segev

    2010-06-01

    Full Text Available This article examines the promoting and impeding factors that advance the turning point in thelives of battered women. The subject is important because of the contribution of the turning pointstage to the ability of women to leave the violent relationship and the way in which the publicwelfare agencies become involved in order to help the victim to advance towards the turning point.The article also reviews the influence of the entertainment media in shaping the positions of thepublic regarding marital violence, the presentation of battered women in the media, and theconnection between their media presentation and their advancement towards the turning point inreality.The research is based on a combination of qualitative and quantitative data, and focuses on contentanalysis. The qualitative content analysis included 40 journal articles, 1 documentary film and onedrama series, the personal interviews included 8 social workers and 6 journalists, and the focusgroup included 8 battered women. The findings indicate an awareness of battered women in thevarious media, and of a gap between the perception of social workers and the journalists regardingthe role of the media in raising social problems.The article calls for cooperation between the media and the professionals in order to construct messages of empowerment that will enable women to advance towards the turning point in theirlives.

  11. Turn-off failure in multi-finger SOI-LIGBT used for single chip inverter ICs

    Science.gov (United States)

    Zhang, Long; Zhu, Jing; Zhao, Minna; Huang, Xuequan; Chen, Jiajun; Sun, Weifeng; Ding, Desheng

    2017-11-01

    In this paper, the clamped inductive turn-off failure of the Silicon-on-Insulator Lateral Insulated Gate Bipolar Transistor (SOI-LIGBT) with multiple fingers under high-voltage and high-current conditions is investigated. First, the measured turn-off waveforms combining with the on-state I-V characteristics of the failed device are discussed to distinguish the probable cause of the failure. Then, two-dimensional (2-D) electrothermal simulations are performed to reproduce the failure by using Sentaurus TCAD. The failure is originated from an inhomogeneous depletion behavior among the paralleled fingers during the turn-off, which gives rise to the non-uniform current-sharing and the subsequent current crowding in single finger. As a result, the latch-up of the device takes place. The simulation indicates that the current crowding is formed mainly through an internal path in the silicon. In order to verify the failure mechanism, an improved device with deep-oxide trenches arranged between the adjacent fingers is fabricated. The measured results demonstrate that no failure occurs when the improved device turns off under high-voltage and high-current conditions.

  12. Diamond turning of glass

    Energy Technology Data Exchange (ETDEWEB)

    Blackley, W.S.; Scattergood, R.O.

    1988-12-01

    A new research initiative will be undertaken to investigate the critical cutting depth concepts for single point diamond turning of brittle, amorphous materials. Inorganic glasses and a brittle, thermoset polymer (organic glass) are the principal candidate materials. Interrupted cutting tests similar to those done in earlier research are Ge and Si crystals will be made to obtain critical depth values as a function of machining parameters. The results will provide systematic data with which to assess machining performance on glasses and amorphous materials

  13. Comments on Marianne Celce-Murcia, Zoltan Dornyei, and Sarah Thurrell's "Direct Approaches in L2 Instruction: A Turning Point in Communicative Language Teaching."

    Science.gov (United States)

    Thornbury, Scott; Celce-Murcia, Marianne; Dornyei, Zoltan; Thurrell, Sarah; Davidson, Bruce W.; Gieve, Simon; Hawkins, Margaret R.; Atkinson, Dwight

    1998-01-01

    Scott Thornbury's response to the Forum article, "Direct Approaches in L2 Instruction: A Turning Point in Communicative Language Teaching" is followed by a response from the authors of that article. Three readers react to another article, "A Critical Approach to Critical Thinking in TESOL." The author of that article then responds to the comments.…

  14. Wear monitoring of single point cutting tool using acoustic emission ...

    Indian Academy of Sciences (India)

    This paper examines the flank and crater wear characteristics of coated carbide tool inserts during dry turning of steel workpieces. A brief review of tool wear mechanisms is presented together with new evidence showing that wear of the TiC layer on both flank and rake faces is dominated by discrete plastic deformation, ...

  15. Single-frequency, single-receiver terrestrial and spaceborne point positioning

    Science.gov (United States)

    Beran, Tomas

    High-accuracy, point positioning has been an attractive research topic in the GPS community for a number of years. The overall quality of precise point positioning results is also dependent on the quality of the GPS measurements and the user's processing software. Dual-frequency, geodetic-quality GPS receivers are routinely used both in static and kinematic applications for high-accuracy point positioning. However, use of low-cost, single-frequency GPS receivers in similar applications creates a challenge because of difficulty of handling the ionosphere, multipath and other measurement error sources. Potential use of such receivers to provide horizontal positioning accuracies of a few decimetres, and vertical accuracies of less than two metres, will be examined in this dissertation. Practical applications of post-processed, high-accuracy, single-frequency point positioning include a myriad of terrestrial and space-borne applications, where the size and cost of the GPS unit is an issue. The processing technique uses pseudorange and time-differenced carrier-phase measurements in a sequential least-squares filter. In developing the approach, different techniques were investigated. Ionospheric delay grid maps are used to remove the bulk of the ionospheric error, while tropospheric error is handled by a prediction model. Pseudorange multipath errors are mitigated by means of stochastic modelling and carrier-phase cycle slips are detected and corrupted measurements are removed in a quality-control algorithm. The technique was first tested on L1 measurements extracted from datasets from static, high-quality GPS receivers. Accuracies better than two-decimetres in horizontal components (northing and easting r.m.s.), and three-decimetre accuracies in the vertical component (up-component r.m.s.), were obtained. A test dataset from a stationary low-cost GPS receiver has been processed to demonstrate the difference in data quality. Positioning results obtained are worse than

  16. Canard solution and its asymptotic approximation in a second-order nonlinear singularly perturbed boundary value problem with a turning point

    Science.gov (United States)

    Shen, Jianhe; Han, Maoan

    2014-08-01

    This paper considers the existence and uniformly valid asymptotic approximation of canard solutions in a second-order nonlinear singularly perturbed boundary value problem with a turning point. We get the main results by constructing the asymptotic solution first and then defining a couple of upper and lower solutions suitably on the basis of the asymptotic solution. Two examples are carried out to illustrate and verify the theoretical results.

  17. Auto-ethnographical investigation of turning points in dance education – a method for creating awareness of one’s own pre-understanding in qualitative research

    Directory of Open Access Journals (Sweden)

    Trine Ørbæk

    2013-06-01

    Full Text Available This article presents an auto-ethnographical investigation of a pedagogical practice in creative dance education. This research is a part of the PhD-project “To create dance” in physical education teacher education based at The Norwegian School of Sport Sciences and The Norwegian National Graduate School in Teacher Education. The method used is based on life stories, and turning points are used as analytical tools. The turning point analysis highlights that an auto-ethnographical investigation is relevant when it comes to creating awareness of pre-understandings in the development of pedagogical experiences from one’s own research field. In addition, the article shows that the turning point analysis may contribute to increasing knowledge on how one’s own experience can change when narrated in new ways. Finally, the study shows that making use of auto-ethnography may also have value as a reflexive approach for becoming more conscious of one’s own research process.

  18. A turning point for natural product discovery - ESF-EMBO research conference : synthetic biology of antibiotic production

    NARCIS (Netherlands)

    Takano, Eriko; Bovenberg, Roel A. L.; Breitling, Rainer

    Synthetic Biology is in a critical phase of its development: it has finally reached the point where it can move from proof-of-principle studies to real-world applications. Secondary metabolite biosynthesis, especially the discovery and production of antibiotics, is a particularly relevant target

  19. Engineering design and integration of in-vessel single turn segmental coil in vacuum vessel of SST-1

    Science.gov (United States)

    Jayswal, Snehal; Chauhan, P.; Santra, P.; Vasava, K.; Perekh, T.; Patel, H.; Biswas, P.; Pradhan, S.

    2017-04-01

    SST-1 tokamak is having the error field due to unsymmetrical positioning of Toroidal field coils which push the plasma to inner side from its major radius of 1100 mm. hence it is required to install the In-vessel Coil (PF6) at a location of 1350 mm radius and elevation of 350 mm above and below the mid plane of the toroidal field coils. The In-Vessel coil was decided to make in eight segments for futuristic use, to control the individual localized error field correction by supplying the different current. A single turn, eight segments, copper conductor with 18 mm diameter with GFRP insulation and in housed in SS304 L casing to carry 8000 A current for 10 s was designed and installed in vacuum vessel of SST-1. This paper will present the design drivers, material selection, advantages and constraints of the in-vessel coils, its conceptual and engineering design, CAD models, finite element analysis using ANSYS, its fabrication, quality assurance/control and assembly/integration aspects inside vacuum vessel of SST-1.

  20. Learning turning points--in life with long-term illness--visualized with the help of the life-world philosophy.

    Science.gov (United States)

    Berglund, Mia M U

    2014-01-01

    A long-term illness is an occurrence that changes one's life and generates a need to learn how to live with it. This article is based on an empirical study of interviews on people living with different long-term illnesses. The results have shown that the learning process is a complex phenomenon interwoven with life as a whole. The essential meaning of learning to live with long-term illness concerns a movement toward a change of understanding of access to the world. In this movement, in which everyday lives as well as relationships with oneself and others are affected, a continual renegotiation is needed. Texts from existential/lifeworld philosopher, Heidegger and Gadamer, have been used to get a greater understanding of the empirical results. These texts have been analysed with particular focus on learning turning points and the importance of reflection. The results are highlighted under the following themes: Pursuit of balance-the aim of learning, The tense grip-the resistance to learning, To live more really-the possibilities of the learning, Distancing-the how of the learning, and The tense of the learning-the whole of the learning. In those learning turning points are present. Knowledge from this study has been used to make a didactic model designed to give caregivers a tool to support patients' learning. The didactic model is called: The challenge to take charge of life with a long-term illness.

  1. Comparing Single-Point and Multi-point Calibration Methods in Modulated DSC

    Energy Technology Data Exchange (ETDEWEB)

    Van Buskirk, Caleb Griffith [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-06-14

    Heat capacity measurements for High Density Polyethylene (HDPE) and Ultra-high Molecular Weight Polyethylene (UHMWPE) were performed using Modulated Differential Scanning Calorimetry (mDSC) over a wide temperature range, -70 to 115 °C, with a TA Instruments Q2000 mDSC. The default calibration method for this instrument involves measuring the heat capacity of a sapphire standard at a single temperature near the middle of the temperature range of interest. However, this method often fails for temperature ranges that exceed a 50 °C interval, likely because of drift or non-linearity in the instrument's heat capacity readings over time or over the temperature range. Therefore, in this study a method was developed to calibrate the instrument using multiple temperatures and the same sapphire standard.

  2. Is This The Turning Point?

    African Journals Online (AJOL)

    denise

    published with the aim of stimulating debate around the issue of qualitative research in Psychology. This is especially important in view of the ..... structure, content, and function of the stories that we tell each other and ourselves in social ... used in biographical and life-history research (p. 103) but that it can be extended to ...

  3. Is This The Turning Point?

    African Journals Online (AJOL)

    denise

    Readers should note that the paper below - penned by one of the journal's editorial panelists - is being published with the aim of stimulating debate around the issue of qualitative research in Psychology. This is especially important in view of the multiple methodologies that are prevalent within the broad scope of the.

  4. Responsiveness of Myofascial Trigger Points to Single and Multiple Trigger Point Release Massages: A Randomized, Placebo Controlled Trial.

    Science.gov (United States)

    Moraska, Albert F; Schmiege, Sarah J; Mann, John D; Butryn, Nathan; Krutsch, Jason P

    2017-09-01

    This study aimed to assess the effects of single and multiple massage treatments on pressure-pain threshold (PPT) at myofascial trigger points (MTrPs) in people with myofascial pain syndrome expressed as tension-type headache. Individuals (n = 62) with episodic or chronic tension-type headache were randomized to receive 12 twice-weekly 45-min massage or sham ultrasound sessions or wait-list control. Massage focused on trigger point release (ischemic compression) of MTrPs in the bilateral upper trapezius and suboccipital muscles. PPT was measured at MTrPs with a pressure algometer pre and post the first and final (12th) treatments. PPT increased across the study timeframe in all four muscle sites tested for massage, but not sham ultrasound or wait-list groups (P trigger points to myofascial pain; (2) Describe an effective treatment for decreasing tenderness of a myofascial trigger point; and (3) Discuss the relative values of single vs. multiple massage sessions on increasing pressure-pain thresholds at myofascial trigger points. Advanced ACCREDITATION: The Association of Academic Physiatrists is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.The Association of Academic Physiatrists designates this Journal-based CME activity for a maximum of 0.5 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

  5. Keys to Successful Diabetes Self-Management for Uninsured Patients: Social Support, Observational Learning, and Turning Points A Safety Net Providers’ Strategic Alliance Study

    Science.gov (United States)

    Hanahan, Melissa A.; Werner, James J.; Tomsik, Phillip; Weirich, Stephen A.; Reichsman, Ann; Navracruz, Lisa; Clemons-Clark, Terri; Cella, Peggi; Terchek, Joshua; Munson, Michelle R.

    2015-01-01

    Objective To determine how medically uninsured patients with limited material resources successfully manage diabetes. Methods Clinicians at 5 safety net practices enrolled uninsured adult patients (N=26) with prior diagnosis of diabetes for 6 months or longer. Patients were interviewed about enabling factors, motivations, resources, and barriers. Chart reviews and clinician surveys supplemented interview data. Interview, survey, and chart review data were analyzed and findings were summarized. Results Two distinct groups of patients were investigated: 1) “successful,” defined as those with an HbA1c of ≤7% or a recent improvement of at least 2% (n=17); and 2) “unsuccessful,” defined as patients with HbA1c of ≥9% (n=9) without recent improvement. In comparison to unsuccessful patients, successful patients more often reported having friends or family with diabetes, sought information about the disease, used evidence-based self-management strategies, held an accurate perception of their own disease control, and experienced “turning point” events that motivated increased efforts in disease management. Conclusions Uninsured safety net patients who successfully managed diabetes learned from friends and family with diabetes and leveraged disease-related events into motivational turning points. It may be beneficial for clinicians to incorporate social learning and motivational enhancement into diabetes interventions to increase patients’ motivation for improved levels of self-management. PMID:21671529

  6. Keys to successful diabetes self-management for uninsured patients: social support, observational learning, and turning points: a safety net providers' strategic alliance study.

    Science.gov (United States)

    Madden, Melissa Hanahan; Tomsik, Philip; Terchek, Joshua; Navracruz, Lisa; Reichsman, Ann; Clark, Terri Clemons; Cella, Peggi; Weirich, Stephen A; Munson, Michelle R; Werner, James J

    2011-03-01

    To examine how medically uninsured patients who receive health care at federally qualified health centers and free clinics are able to successfully self-manage diabetes compared to patients who are less successful. Two distinct groups of patients with diabetes for 6 months or longer were enrolled: (1) successful, defined as those with glycated hemoglobin (HbA1c) of 7% or less or a recent improvement of at least 2% (n=17); and (2) unsuccessful, defined as patients with HbAlc of at least 9% (n=9) and without recent improvement. Patients were interviewed about enabling factors, motivators, resources, and barriers to diabetes self-management. Data from interviews, chart reviews, and clinician surveys were analyzed using qualitative methods and statistical techniques. African Americans comprised 57.7% of the sample and whites 38.5% (N=26). No significant differences were detected between successful and unsuccessful groups in age, race, education, or employment status. Clinicians rated unsuccessful patients as having more severe diabetes and significantly lower levels of control than successful patients. Compared to unsuccessful patients, successful patients more often reported having friends or family with diabetes, more frequently sought information about the disease, used evidence-based self-management strategies, held more accurate perceptions of their own diabetes control, and experienced "turning point" events that motivated increased efforts in disease management. Patients who successfully managed diabetes learned from diabetic family members and interpreted disease-related events as motivational turning points. It may be beneficial to incorporate social learning and motivational enhancement into diabetes interventions to increase patients' motivation for improved levels of self-management.

  7. Comparison of Single-Point and Continuous Sampling Methods for Estimating Residential Indoor Temperature and Humidity.

    Science.gov (United States)

    Johnston, James D; Magnusson, Brianna M; Eggett, Dennis; Collingwood, Scott C; Bernhardt, Scott A

    2015-01-01

    Residential temperature and humidity are associated with multiple health effects. Studies commonly use single-point measures to estimate indoor temperature and humidity exposures, but there is little evidence to support this sampling strategy. This study evaluated the relationship between single-point and continuous monitoring of air temperature, apparent temperature, relative humidity, and absolute humidity over four exposure intervals (5-min, 30-min, 24-hr, and 12-days) in 9 northern Utah homes, from March-June 2012. Three homes were sampled twice, for a total of 12 observation periods. Continuous data-logged sampling was conducted in homes for 2-3 wks, and simultaneous single-point measures (n = 114) were collected using handheld thermo-hygrometers. Time-centered single-point measures were moderately correlated with short-term (30-min) data logger mean air temperature (r = 0.76, β = 0.74), apparent temperature (r = 0.79, β = 0.79), relative humidity (r = 0.70, β = 0.63), and absolute humidity (r = 0.80, β = 0.80). Data logger 12-day means were also moderately correlated with single-point air temperature (r = 0.64, β = 0.43) and apparent temperature (r = 0.64, β = 0.44), but were weakly correlated with single-point relative humidity (r = 0.53, β = 0.35) and absolute humidity (r = 0.52, β = 0.39). Of the single-point RH measures, 59 (51.8%) deviated more than ±5%, 21 (18.4%) deviated more than ±10%, and 6 (5.3%) deviated more than ±15% from data logger 12-day means. Where continuous indoor monitoring is not feasible, single-point sampling strategies should include multiple measures collected at prescribed time points based on local conditions.

  8. Diamond turning of thermoplastic polymers

    Energy Technology Data Exchange (ETDEWEB)

    Smith, E.; Scattergood, R.O.

    1988-12-01

    Single point diamond turning studies were made using a series of thermoplastic polymers with different glass transition temperatures. Variations in surface morphology and surface roughness were observed as a function of cutting speed. Lower glass transition temperatures facilitate smoother surface cuts and better surface finish. This can be attributed to the frictional heating that occurs during machining. Because of the very low glass transition temperatures in polymeric compared to inorganic glasses, the precision machining response can be very speed sensitive.

  9. Single Point Adjustments: A New Definition with Examples. Acquisition Review Quarterly, Fall 2001

    National Research Council Canada - National Science Library

    Bachman, David

    2002-01-01

    .... A single point adjustment (SPA) is made when a contract's existing cost and/or schedule variances are set to zero and all the remaining work is replanned with the goal of completing the project on schedule and on budget...

  10. Lasing thresholds of helical photonic structures with different positions of a single light-amplifying helix turn

    Energy Technology Data Exchange (ETDEWEB)

    Blinov, L M; Palto, S P [A.V. Shubnikov Institute of Crystallography, Russian Academy of Sciences, Moscow, Russian Federaion (Russian Federation)

    2013-09-30

    Numerical simulation is used to assess the lasing threshold of helical structures of cholesteric liquid crystals (CLCs) in which only one turn amplifies light. This turn is located either in the centre of symmetric structures of various sizes or in an arbitrary place in asymmetric structures of preset size. In all cases, we find singularities in light amplification by a one-dimensional CLC structure for the most important band-edge modes (m1, m2 and m3) and plot the threshold gain coefficient k{sub th} against the position of the amplifying turn. For the symmetric structures, the lasing threshold of the m1 mode is shown to vary linearly with the inverse of the square of the cavity length. Moreover, modes with a lower density of photonic states (DOS) in the cavity may have a lower lasing threshold. This can be accounted for by the dependence of the density of photonic states on the position of the amplifying turn and, accordingly, by the nonuniform electromagnetic field intensity distribution along the cavity for different modes. In the asymmetric structures, the same field energy distribution is responsible for a correlation between k{sub th} and DOS curves. (lasers)

  11. SEE Transient Response of Crane Interpoint Single Output Point of Load DC-DC Converters

    Science.gov (United States)

    Sanders, Anthony B.; Chen, Dakai; Kim, Hak S.; Phan, Anthony M.

    2011-01-01

    This study was undertaken to determine the single event effect and transient susceptibility of the Crane Interpoint Maximum Flexible Power (MFP) Single Output Point of Load DC/DC Converters for transient interruptions in the output signal and for destructive and non destructive events induced by exposing it to a heavy ion beam..

  12. Detection of kinetic change points in piece-wise linear single molecule motion

    Science.gov (United States)

    Hill, Flynn R.; van Oijen, Antoine M.; Duderstadt, Karl E.

    2018-03-01

    Single-molecule approaches present a powerful way to obtain detailed kinetic information at the molecular level. However, the identification of small rate changes is often hindered by the considerable noise present in such single-molecule kinetic data. We present a general method to detect such kinetic change points in trajectories of motion of processive single molecules having Gaussian noise, with a minimum number of parameters and without the need of an assumed kinetic model beyond piece-wise linearity of motion. Kinetic change points are detected using a likelihood ratio test in which the probability of no change is compared to the probability of a change occurring, given the experimental noise. A predetermined confidence interval minimizes the occurrence of false detections. Applying the method recursively to all sub-regions of a single molecule trajectory ensures that all kinetic change points are located. The algorithm presented allows rigorous and quantitative determination of kinetic change points in noisy single molecule observations without the need for filtering or binning, which reduce temporal resolution and obscure dynamics. The statistical framework for the approach and implementation details are discussed. The detection power of the algorithm is assessed using simulations with both single kinetic changes and multiple kinetic changes that typically arise in observations of single-molecule DNA-replication reactions. Implementations of the algorithm are provided in ImageJ plugin format written in Java and in the Julia language for numeric computing, with accompanying Jupyter Notebooks to allow reproduction of the analysis presented here.

  13. Single purse string with four-point traction for better haemorrhoid retraction.

    Science.gov (United States)

    Chen, Shao-Quan; Cai, Ai-Zhen; Wang, Ning; Chen, Lin

    2012-10-01

    Traction method is important to stapled haemorrhoidopexy (SH) for its impact on haemorrhoidal prolapse reduction. Single purse string with one-point traction is most commonly used in SH. This traction method often results in an irregular mucosal doughnut with inadequate height, which leads to insignificant and uneven haemorrhoidal prolapse reduction. Single purse string with two-point traction is a modified traction method. According to some authors, it has significantly improved the height and regularity of the mucosal doughnut in SH. However, the reduction of haemorrhoidal prolapse is not always satisfactory, especially in patients with large prolapse. Our assumption is that single purse string with four-point traction, a more balanced traction method, will provide better control to increase the doughnut height using the same amount of traction. This study was designed to evaluate the outcomes of single purse string with four-point traction as compared with two-point traction in SH. Consecutive patients with symptomatic grade III haemorrhoids were randomized to two groups: Group 1, G(1) ; Group 2, G(2) . Each group underwent SH by colorectal surgeons. The patients in G(1) underwent single purse string with two-point traction. The patients in G(2) underwent SH using single purse string with four-point traction. Preoperative, intraoperative and post-operative patient characteristics were evaluated. Sixty patients with a median age of 44 (range, 21-78) years were identified. Patient demographic and clinical characteristics were similar in the two groups. The height of the mucosectomy specimens significantly increased in patients of G(2) (P string with four-point traction ensures a taller and more regular mucosal doughnut during SH, thus it brings a more satisfactory haemorrhoid retraction. © 2012 The Authors. ANZ Journal of Surgery © 2012 Royal Australasian College of Surgeons.

  14. Estimating Total Heliospheric Magnetic Flux from Single-Point in Situ Measurements

    Science.gov (United States)

    Owens, M. J.; Arge, C. N.; Crooker, N. U.; Schwardron, N. A.; Horbury, T. S.

    2008-01-01

    A fraction of the total photospheric magnetic flux opens to the heliosphere to form the interplanetary magnetic field carried by the solar wind. While this open flux is critical to our understanding of the generation and evolution of the solar magnetic field, direct measurements are generally limited to single-point measurements taken in situ by heliospheric spacecraft. An observed latitude invariance in the radial component of the magnetic field suggests that extrapolation from such single-point measurements to total heliospheric magnetic flux is possible. In this study we test this assumption using estimates of total heliospheric flux from well-separated heliospheric spacecraft and conclude that single-point measurements are indeed adequate proxies for the total heliospheric magnetic flux, though care must be taken when comparing flux estimates from data collected at different heliocentric distances.

  15. Limited effect of dopaminergic medication on straight walking and turning in early to moderate Parkinson’s disease during single and dual tasking

    Directory of Open Access Journals (Sweden)

    Morad eElshehabi

    2016-01-01

    Full Text Available Background: In Parkinson’s disease (PD, the effects of dopaminergic medication on straight walking and turning were mainly investigated under single tasking (ST conditions. However, multitasking situations are considered more daily relevant.Methods: Thirty-nine early to moderate PD patients performed the following standarized ST and dual tasks (DT as fast as possible for one minute during On- and Off-medication while wearing inertial sensors: straight walking and turning, checking boxes, and subtracting serial 7s. Quantitative gait parameters, as well as velocity of the secondary tasks were analyzed.Results: The following parameters improved significantly in On-medication during ST: gait velocity during straight walking (p=0.03; step duration (p=0.048 and peak velocity (p=0.04 during turning; velocity of checking boxes during ST (p=0.04 and DT (p=0.04. Velocity of checking boxes was the only parameter that also improved during DT.Conclusion: These results suggest that dopaminergic medication does not relevantly influence straight walking and turning in early to moderate PD during DT.

  16. Soft-Switched Neutral-Point-Clamped Single-Phase Boost Rectifier

    Science.gov (United States)

    Itoh, Ryozo; Ishizaka, Kouichi

    A soft-switched neutral-point-clamped single-phase boost rectifier capable of compensating the imbalance load voltage is studied. This is based on a single-phase rectifier, in which an inductor is placed in series with the AC supply to resonate with a capacitor connected across the DC output of a full-bridge rectifier and the switching transition is mainly governed by a series resonance. The experimental prototype using insulated-gate bipolar transistors is implemented to investigate the operation under the charge control. The experimental results confirm that the rectifier has a neutral-point-clamp feature providing a good quality AC current.

  17. A Study of Impulsive Multiterm Fractional Differential Equations with Single and Multiple Base Points and Applications

    Directory of Open Access Journals (Sweden)

    Yuji Liu

    2014-01-01

    Full Text Available We discuss the existence and uniqueness of solutions for initial value problems of nonlinear singular multiterm impulsive Caputo type fractional differential equations on the half line. Our study includes the cases for a single base point fractional differential equation as well as multiple base points fractional differential equation. The asymptotic behavior of solutions for the problems is also investigated. We demonstrate the utility of our work by applying the main results to fractional-order logistic models.

  18. The short-term effects of trigger point therapy, stretching and medicine ball exercises on accuracy and back swing hip turn in elite, male golfers - A randomised controlled trial.

    Science.gov (United States)

    Quinn, Samantha-Lynn; Olivier, Benita; Wood, Wendy-Ann

    2016-11-01

    This study aimed to compare the effect of myofascial trigger point therapy (MTPT) and stretching, MTPT and medicine ball exercises, and no intervention, on hip flexor length (HFL), golf swing biomechanics and performance in elite, male golfers. Single blind, randomised controlled trial with two experimental groups (stretch group: MTPT and stretching; and the ball group: MTPT, a single stretch and medicine ball exercises) and one control group (no intervention). Professional golf academy. One hundred, elite, male golfers aged 16-25 years. HFL, 3D biomechanical analysis of the golf swing, club head speed (CHS), smash ratio, accuracy and distance at baseline and after the interventions. Backswing hip turn (BSHT) improved in the ball group relative to the control group (p = 0.0248). Accuracy in the ball group and the stretch group improved relative to the control group (Fisher's exact = 0.016). Other performance parameters such as: smash ratio, distance and CHS were not compromised by either intervention. This study advocates the use of MTPT combined with medicine ball exercises over MTPT combined with stretching in the treatment of golfers with shortened hip flexors - even immediately preceding a tournament. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. SCAP-82, Single Scattering, Albedo Scattering, Point-Kernel Analysis in Complex Geometry

    International Nuclear Information System (INIS)

    Disney, R.K.; Vogtman, S.E.

    1987-01-01

    1 - Description of problem or function: SCAP solves for radiation transport in complex geometries using the single or albedo scatter point kernel method. The program is designed to calculate the neutron or gamma ray radiation level at detector points located within or outside a complex radiation scatter source geometry or a user specified discrete scattering volume. Geometry is describable by zones bounded by intersecting quadratic surfaces within an arbitrary maximum number of boundary surfaces per zone. Anisotropic point sources are describable as pointwise energy dependent distributions of polar angles on a meridian; isotropic point sources may also be specified. The attenuation function for gamma rays is an exponential function on the primary source leg and the scatter leg with a build- up factor approximation to account for multiple scatter on the scat- ter leg. The neutron attenuation function is an exponential function using neutron removal cross sections on the primary source leg and scatter leg. Line or volumetric sources can be represented as a distribution of isotropic point sources, with un-collided line-of-sight attenuation and buildup calculated between each source point and the detector point. 2 - Method of solution: A point kernel method using an anisotropic or isotropic point source representation is used, line-of-sight material attenuation and inverse square spatial attenuation between the source point and scatter points and the scatter points and detector point is employed. A direct summation of individual point source results is obtained. 3 - Restrictions on the complexity of the problem: - The SCAP program is written in complete flexible dimensioning so that no restrictions are imposed on the number of energy groups or geometric zones. The geometric zone description is restricted to zones defined by boundary surfaces defined by the general quadratic equation or one of its degenerate forms. The only restriction in the program is that the total

  20. Bayesian unknown change-point models to investigate immediacy in single case designs.

    Science.gov (United States)

    Natesan, Prathiba; Hedges, Larry V

    2017-12-01

    Although immediacy is one of the necessary criteria to show strong evidence of a causal relation in single case designs (SCDs), no inferential statistical tool is currently used to demonstrate it. We propose a Bayesian unknown change-point model to investigate and quantify immediacy in SCD analysis. Unlike visual analysis that considers only 3-5 observations in consecutive phases to investigate immediacy, this model considers all data points. Immediacy is indicated when the posterior distribution of the unknown change-point is narrow around the true value of the change-point. This model can accommodate delayed effects. Monte Carlo simulation for a 2-phase design shows that the posterior standard deviations of the change-points decrease with increase in standardized mean difference between phases and decrease in test length. This method is illustrated with real data. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  1. Single-Molecule Counting of Point Mutations by Transient DNA Binding

    Science.gov (United States)

    Su, Xin; Li, Lidan; Wang, Shanshan; Hao, Dandan; Wang, Lei; Yu, Changyuan

    2017-03-01

    High-confidence detection of point mutations is important for disease diagnosis and clinical practice. Hybridization probes are extensively used, but are hindered by their poor single-nucleotide selectivity. Shortening the length of DNA hybridization probes weakens the stability of the probe-target duplex, leading to transient binding between complementary sequences. The kinetics of probe-target binding events are highly dependent on the number of complementary base pairs. Here, we present a single-molecule assay for point mutation detection based on transient DNA binding and use of total internal reflection fluorescence microscopy. Statistical analysis of single-molecule kinetics enabled us to effectively discriminate between wild type DNA sequences and single-nucleotide variants at the single-molecule level. A higher single-nucleotide discrimination is achieved than in our previous work by optimizing the assay conditions, which is guided by statistical modeling of kinetics with a gamma distribution. The KRAS c.34 A mutation can be clearly differentiated from the wild type sequence (KRAS c.34 G) at a relative abundance as low as 0.01% mutant to WT. To demonstrate the feasibility of this method for analysis of clinically relevant biological samples, we used this technology to detect mutations in single-stranded DNA generated from asymmetric RT-PCR of mRNA from two cancer cell lines.

  2. Evaluating Change in Behavioral Preferences: Multidimensional Scaling Single-Ideal Point Model

    Science.gov (United States)

    Ding, Cody

    2016-01-01

    The purpose of the article is to propose a multidimensional scaling single-ideal point model as a method to evaluate changes in individuals' preferences under the explicit methodological framework of behavioral preference assessment. One example is used to illustrate the approach for a clear idea of what this approach can accomplish.

  3. Mechanism of DNA–binding loss upon single-point mutation in p53

    Indian Academy of Sciences (India)

    PRAKASH KUMAR

    provides an excellent prototype system to elucidate the different mechanisms underlying the loss in DNA binding affinity and specificity upon single point mutation because over 50% of all human cancers involve p53 mutations, which occur mostly in the sequence–specific DNA–binding central domain (residues 102–292, ...

  4. Single stage buck-boost DC-AC neutral point clamped inverter

    DEFF Research Database (Denmark)

    Mo, Wei; Loh, Poh Chiang; Andrew, A.

    2012-01-01

    This paper proposes a new single stage buck-boost DC-AC neutral point clamped inverter topology which integrates the cascaded configurations of recently introduced inductor-capacitor-capacitor-transformer impedance source network (by Adamowicz) and classic NPC configuration. As a consequence...

  5. Real-time multi-GNSS single-frequency precise point positioning

    NARCIS (Netherlands)

    de Bakker, P.F.; Tiberius, C.C.J.M.

    2017-01-01

    Precise Point Positioning (PPP) is a popular Global Positioning System (GPS) processing strategy, thanks to its high precision without requiring additional GPS infrastructure. Single-Frequency PPP (SF-PPP) takes this one step further by no longer relying on expensive dual-frequency GPS receivers,

  6. SINGLE TREE DETECTION FROM AIRBORNE LASER SCANNING DATA USING A MARKED POINT PROCESS BASED METHOD

    Directory of Open Access Journals (Sweden)

    J. Zhang

    2013-05-01

    Full Text Available Tree detection and reconstruction is of great interest in large-scale city modelling. In this paper, we present a marked point process model to detect single trees from airborne laser scanning (ALS data. We consider single trees in ALS recovered canopy height model (CHM as a realization of point process of circles. Unlike traditional marked point process, we sample the model in a constraint configuration space by making use of image process techniques. A Gibbs energy is defined on the model, containing a data term which judge the fitness of the model with respect to the data, and prior term which incorporate the prior knowledge of object layouts. We search the optimal configuration through a steepest gradient descent algorithm. The presented hybrid framework was test on three forest plots and experiments show the effectiveness of the proposed method.

  7. Generating and executing programs for a floating point single instruction multiple data instruction set architecture

    Science.gov (United States)

    Gschwind, Michael K

    2013-04-16

    Mechanisms for generating and executing programs for a floating point (FP) only single instruction multiple data (SIMD) instruction set architecture (ISA) are provided. A computer program product comprising a computer recordable medium having a computer readable program recorded thereon is provided. The computer readable program, when executed on a computing device, causes the computing device to receive one or more instructions and execute the one or more instructions using logic in an execution unit of the computing device. The logic implements a floating point (FP) only single instruction multiple data (SIMD) instruction set architecture (ISA), based on data stored in a vector register file of the computing device. The vector register file is configured to store both scalar and floating point values as vectors having a plurality of vector elements.

  8. Point defects in lines in single crystalline phosphorene: directional migration and tunable band gaps.

    Science.gov (United States)

    Li, Xiuling; Ma, Liang; Wang, Dayong; Zeng, Xiao Cheng; Wu, Xiaojun; Yang, Jinlong

    2016-10-20

    Extended line defects in two-dimensional (2D) materials can play an important role in modulating their electronic properties. During the experimental synthesis of 2D materials, line defects are commonly generated at grain boundaries between domains of different orientations. In this work, twelve types of line-defect structures in single crystalline phosphorene are examined by using first-principles calculations. These line defects are typically formed via migration and aggregation of intrinsic point defects, including the Stone-Wales (SW), single or double vacancy (SV or DV) defects. Our calculated results demonstrate that the migration of point defects in phosphorene is anisotropic, for instance, the lowest migration energy barriers are 1.39 (or 0.40) and 2.58 (or 0.49) eV for SW (or SV) defects in zigzag and armchair directions, respectively. The aggregation of point defects into lines is energetically favorable compared with the separated point defects in phosphorene. In particular, the axis of line defects in phosphorene is direction-selective, depending on the composed point defects. The presence of line defects effectively modulates the electronic properties of phosphorene, rendering the defect-containing phosphorene either metallic or semiconducting with a tunable band gap. Of particular interest is the fact that the SV-based line defect can behave as a metallic wire, suggesting a possibility to fabricate a circuit with subnanometer widths in the semiconducting phosphorene for nanoscale electronic application.

  9. Design of an omnidirectional single-point photodetector for large-scale spatial coordinate measurement

    Science.gov (United States)

    Xie, Hongbo; Mao, Chensheng; Ren, Yongjie; Zhu, Jigui; Wang, Chao; Yang, Lei

    2017-10-01

    In high precision and large-scale coordinate measurement, one commonly used approach to determine the coordinate of a target point is utilizing the spatial trigonometric relationships between multiple laser transmitter stations and the target point. A light receiving device at the target point is the key element in large-scale coordinate measurement systems. To ensure high-resolution and highly sensitive spatial coordinate measurement, a high-performance and miniaturized omnidirectional single-point photodetector (OSPD) is greatly desired. We report one design of OSPD using an aspheric lens, which achieves an enhanced reception angle of -5 deg to 45 deg in vertical and 360 deg in horizontal. As the heart of our OSPD, the aspheric lens is designed in a geometric model and optimized by LightTools Software, which enables the reflection of a wide-angle incident light beam into the single-point photodiode. The performance of home-made OSPD is characterized with working distances from 1 to 13 m and further analyzed utilizing developed a geometric model. The experimental and analytic results verify that our device is highly suitable for large-scale coordinate metrology. The developed device also holds great potential in various applications such as omnidirectional vision sensor, indoor global positioning system, and optical wireless communication systems.

  10. Identification of Intensity Ratio Break Points from Photon Arrival Trajectories in Ratiometric Single Molecule Spectroscopy

    Science.gov (United States)

    Bingemann, Dieter; Allen, Rachel M.

    2012-01-01

    We describe a statistical method to analyze dual-channel photon arrival trajectories from single molecule spectroscopy model-free to identify break points in the intensity ratio. Photons are binned with a short bin size to calculate the logarithm of the intensity ratio for each bin. Stochastic photon counting noise leads to a near-normal distribution of this logarithm and the standard student t-test is used to find statistically significant changes in this quantity. In stochastic simulations we determine the significance threshold for the t-test’s p-value at a given level of confidence. We test the method’s sensitivity and accuracy indicating that the analysis reliably locates break points with significant changes in the intensity ratio with little or no error in realistic trajectories with large numbers of small change points, while still identifying a large fraction of the frequent break points with small intensity changes. Based on these results we present an approach to estimate confidence intervals for the identified break point locations and recommend a bin size to choose for the analysis. The method proves powerful and reliable in the analysis of simulated and actual data of single molecule reorientation in a glassy matrix. PMID:22837704

  11. Turned on/turned off

    DEFF Research Database (Denmark)

    Petersen, Eva Bendix

    2016-01-01

    position, it attempts to sense into the lived experience of being subject to, and of, turns in social theory. As a whole the paper seeks to work with and allow for multiplicity in tone, focus, researcher positioning, reader positioning, and more, to see what knowledge that does not seek confident closure...

  12. Single point incremental forming of tailored blanks produced by friction stir welding

    DEFF Research Database (Denmark)

    Silva, M.B.; Skjødt, Martin; Vilaca, P.

    2009-01-01

    This paper is focused on the single point incremental forming (SPIF) of tailored welded blanks produced by friction stirwelding (FSW). Special emphasis is placed on the know-how for producing the tailored blanks and on the utilization of innovative forming strategies to protect thewelding joint...... fromthe rotating single point-forming tool. Formability of the tailor welded blanks (TWB) is evaluated by means of benchmark tests carried out on truncated conical and pyramidal shapes and results are compared with similar tests performed on conventional reference blanks of the same material. Results show...... that the combination of SPIF with tailored welded blanks produced by FSW seems promising in the manufacture of complex sheet metal parts with high depths....

  13. Point defects and magnetic properties of neutron irradiated MgO single crystal

    Directory of Open Access Journals (Sweden)

    Mengxiong Cao

    2017-05-01

    Full Text Available (100-oriented MgO single crystals were irradiated to introduce point defects with different neutron doses ranging from 1.0×1016 to 1.0×1020 cm-2. The point defect configurations were studied with X-ray diffuse scattering and UV-Vis absorption spectra. The isointensity profiles of X-ray diffuse scattering caused by the cubic and double-force point defects in MgO were theoretically calculated based on the Huang scattering theory. The magnetic properties at different temperature were measured with superconducting quantum interference device (SQUID. The reciprocal space mappings (RSMs of irradiated MgO revealed notable diffuse scattering. The UV-Vis spectra indicated the presence of O Frenkel defects in irradiated MgO. Neutron-irradiated MgO was diamagnetic at room temperature and became ferromagnetic at low temperature due to O Frenkel defects induced by neutron-irradiation.

  14. Constraining the Pluripotent Fate of Human Embryonic Stem Cells for Tissue Engineering and Cell Therapy - The Turning Point of Cell-Based Regenerative Medicine.

    Science.gov (United States)

    Parsons, Xuejun H

    2013-10-01

    nuclear translocation of the neuronal specific transcription factor Nurr-1. Similarly, nicotinamide was rendered sufficient to induce the specification of cardiomesoderm direct from the pluripotent state of hESCs by promoting the expression of the earliest cardiac-specific transcription factor Csx/Nkx2.5 and triggering progression to cardiac precursors and beating cardiomyocytes with high efficiency. This technology breakthrough enables direct conversion of pluripotent hESCs into a large supply of high purity neuronal cells or heart muscle cells with adequate capacity to regenerate CNS neurons and contractile heart muscles for developing safe and effective stem cell therapies. Transforming pluripotent hESCs into fate-restricted therapy derivatives dramatically increases the clinical efficacy of graft-dependent repair and safety of hESC-derived cellular products. Such milestone advances and medical innovations in hESC research allow generation of a large supply of clinical-grade hESC therapy derivatives targeting for major health problems, bringing cell-based regenerative medicine to a turning point.

  15. Exposure buildup factors for a cobalt-60 point isotropic source for single and two layer slabs

    International Nuclear Information System (INIS)

    Chakarova, R.

    1992-01-01

    Exposure buildup factors for point isotropic cobalt-60 sources are calculated by the Monte Carlo method with statistical errors ranging from 1.5 to 7% for 1-5 mean free paths (mfp) thick water and iron single slabs and for 1 and 2 mfp iron layers followed by water layers 1-5 mfp thick. The computations take into account Compton scattering. The Monte Carlo data for single slab geometries are approximated by Geometric Progression formula. Kalos's formula using the calculated single slab buildup factors may be applied to reproduce the data for two-layered slabs. The presented results and discussion may help when choosing the manner in which the radiation field gamma irradiation units will be described. (author)

  16. The consistency condition for the three-point function in dissipative single-clock inflation

    International Nuclear Information System (INIS)

    Nacir, Diana López; Porto, Rafael A.; Zaldarriaga, Matias

    2012-01-01

    We generalize the consistency condition for the three-point function in single field inflation to the case of dissipative, multi-field, single-clock models. We use the recently introduced extension of the effective field theory of inflation that accounts for dissipative effects, to provide an explicit proof to leading (non-trivial) order in the generalized slow roll parameters and mixing with gravity scales. Our results illustrate the conditions necessary for the validity of the consistency relation in situations with many degrees of freedom relevant during inflation, namely that there is a preferred clock. Departures from this condition in forthcoming experiments would rule out not only single field but also a large class of multi-field models

  17. The consistency condition for the three-point function in dissipative single-clock inflation

    Energy Technology Data Exchange (ETDEWEB)

    Nacir, Diana López [Departamento de Física, Facultad de Ciencias Exactas y Naturales, UBA and IFIBA, CONICET, Ciudad Universitaria, Pabellón 1, 1428, Buenos Aires (Argentina); Porto, Rafael A.; Zaldarriaga, Matias, E-mail: dnacir@df.uba.ar, E-mail: rporto@ias.edu, E-mail: matiasz@ias.edu [School of Natural Sciences, Institute for Advanced Study, Einstein Drive, Princeton, NJ 08540 (United States)

    2012-09-01

    We generalize the consistency condition for the three-point function in single field inflation to the case of dissipative, multi-field, single-clock models. We use the recently introduced extension of the effective field theory of inflation that accounts for dissipative effects, to provide an explicit proof to leading (non-trivial) order in the generalized slow roll parameters and mixing with gravity scales. Our results illustrate the conditions necessary for the validity of the consistency relation in situations with many degrees of freedom relevant during inflation, namely that there is a preferred clock. Departures from this condition in forthcoming experiments would rule out not only single field but also a large class of multi-field models.

  18. Turn Continuation and Clause Combinations

    Science.gov (United States)

    Couper-Kuhlen, Elizabeth

    2012-01-01

    This article explores the viability of the analytic distinction between "turn-constructional unit (TCU) continuation" (i.e., continuing a turn beyond a point of possible completion with grammatically dependent material) and "new TCU" (i.e., continuing a turn with grammatically independent material) when hypotactic clause combinations are involved.…

  19. Tight Turns

    Directory of Open Access Journals (Sweden)

    Jenifer Sutherland

    2013-01-01

    Full Text Available The plain text was task-oriented in a roundabout way, providing detailed instructions for how NOT to build an elaborate sequence of bridges, each one bound to produce, according to chapters one through twenty-three, disastrous results. Graphic novels disguised as illuminated letters twisted the tent-dwelling decipherer into painful self-recognition. The flashlight followed the phases of the moon. Meanwhile one strand of marginalia, written in anxious back-slant, pleaded for some kind of adjustable form for managing the confluence, especially during flood season. I like what we came up with. 'We' is a little big word. In fact the tent turns out to be one of those Borgesian core-tech structures allowing for astonishing internal expansion. There's not much we didn't get in there and not much in there that didn't get us. So I suppose that's it. This tent. This confluence. These children who found me here, turned text into life and made life home.

  20. Coumarins as turn on/off fluorescent probes for detection of residual acetone in cosmetics following headspace single-drop microextraction.

    Science.gov (United States)

    Cabaleiro, N; de la Calle, I; Bendicho, C; Lavilla, I

    2014-11-01

    In this work, a new method based on headspace-single drop microextraction for the determination of residual acetone in cosmetics by microfluorospectrometry is proposed. Acetone causes fluorescence changes in a 2.5 µL-ethanolic drop (40% v/v) containing 3.10(-4) mol L(-1) 7-hydroxy-4-methylcoumarin ('turn off') or 6.10(-6) mol L(-1) 7-diethylamino-4-methylcoumarin ('turn on'). Polarity and ability to form hydrogen bonds of short chain alcohols (polar protic solvents) were crucial in order to observe these changes in the presence of acetone (polar aprotic solvent). Parameters related with the HS-SDME procedure were studied, namely headspace volume, composition, volume and temperature of drop, microextraction time, stirring rate, mass and temperature of sample, as well as the effect of potential interferents (alcohols and fragrances). The high volatility of acetone allows its extraction from an untreated cosmetic sample within 3 min. A detection limit of 0.26 µg g(-1) and repeatability, expressed as relative standard deviation, around 5% were reached. Accuracy of the proposed methodology was evaluated by means of recovery studies. The method was successfully used to analyze different cosmetics. Simplicity and high sample throughput can be highlighted. Copyright © 2014 Elsevier B.V. All rights reserved.

  1. Ultrasonography for suspected deep vein thrombosis: how useful is single-point augmentation?

    Energy Technology Data Exchange (ETDEWEB)

    McQueen, A.S. [Department of Radiology, Freeman Hospital, Newcastle upon Tyne (United Kingdom)], E-mail: andrewmcqueen7@hotmail.com; Elliott, S.T. [Department of Radiology, Freeman Hospital, Newcastle upon Tyne (United Kingdom); Keir, M.J. [Department of Medical Physics, Royal Victoria Infirmary, Newcastle upon Tyne (United Kingdom)

    2009-02-15

    Aims: To assess the role of single-point augmentation of spectral Doppler flow in the diagnosis of acute deep vein thrombosis (DVT). Secondary objectives included identifying the augmentation response in non-DVT diagnoses. Methods: Patients attending the ultrasound departments of two hospitals for investigation of suspected acute DVT during an 8-month period were recruited to the study group. Spectral Doppler assessment of the superficial femoral vein was recorded during Valsalva and calf compression manoeuvres in the asymptomatic and symptomatic legs. The Doppler waveforms from the symptomatic limb were characterized as 'normal' or 'abnormal' by the operator. Standard compression ultrasonography of the symptomatic leg was then performed with the presence of DVT or an alternative diagnosis documented. Results: One hundred and sixty-seven patients underwent ultrasound examinations using the study methodology. Nine patients were subsequently excluded due to bilateral DVT or inability to tolerate calf compression. The mean age of the remaining 158 patients was 65.4 years with 28 DVTs identified (18% of patients). Calf compression elicited a normal response in 118/130 of non-DVT examinations (specificity 91%) and an abnormal response in 18/28 DVT examinations (sensitivity 64%). Diminished or absent augmentation was identified in alternative diagnoses that included haematoma and Baker's cyst. Conclusions: This study demonstrates that single-point augmentation has a low sensitivity in suspected lower-limb DVT, and that the majority of undetected DVTs are isolated to the calf veins. An abnormal augmentation response is a poor predictor of lower-limb DVT as alternative diagnoses can produce diminished or reduced augmentation. Therefore, single-point augmentation does not add to the standard compression ultrasound examination for suspected DVT and should not be routinely performed.

  2. Ultrasonography for suspected deep vein thrombosis: how useful is single-point augmentation?

    International Nuclear Information System (INIS)

    McQueen, A.S.; Elliott, S.T.; Keir, M.J.

    2009-01-01

    Aims: To assess the role of single-point augmentation of spectral Doppler flow in the diagnosis of acute deep vein thrombosis (DVT). Secondary objectives included identifying the augmentation response in non-DVT diagnoses. Methods: Patients attending the ultrasound departments of two hospitals for investigation of suspected acute DVT during an 8-month period were recruited to the study group. Spectral Doppler assessment of the superficial femoral vein was recorded during Valsalva and calf compression manoeuvres in the asymptomatic and symptomatic legs. The Doppler waveforms from the symptomatic limb were characterized as 'normal' or 'abnormal' by the operator. Standard compression ultrasonography of the symptomatic leg was then performed with the presence of DVT or an alternative diagnosis documented. Results: One hundred and sixty-seven patients underwent ultrasound examinations using the study methodology. Nine patients were subsequently excluded due to bilateral DVT or inability to tolerate calf compression. The mean age of the remaining 158 patients was 65.4 years with 28 DVTs identified (18% of patients). Calf compression elicited a normal response in 118/130 of non-DVT examinations (specificity 91%) and an abnormal response in 18/28 DVT examinations (sensitivity 64%). Diminished or absent augmentation was identified in alternative diagnoses that included haematoma and Baker's cyst. Conclusions: This study demonstrates that single-point augmentation has a low sensitivity in suspected lower-limb DVT, and that the majority of undetected DVTs are isolated to the calf veins. An abnormal augmentation response is a poor predictor of lower-limb DVT as alternative diagnoses can produce diminished or reduced augmentation. Therefore, single-point augmentation does not add to the standard compression ultrasound examination for suspected DVT and should not be routinely performed

  3. Assessment of Grade-Level Differences in Coping Behavior among Adolescents Using Multidimensional Scaling Single-Ideal-Point Model

    Science.gov (United States)

    Ding, Cody; Yang, Dong

    2013-01-01

    The purpose of the study was to examine grade-level differences in coping behaviors among adolescents using a probabilistic multidimensional scaling (MDS) single-ideal-point model. Using data from students in middle school and at college, this article illustrated the MDS single-ideal-point model as an alternative to examine students' typical…

  4. Probing Critical Point Energies of Transition Metal Dichalcogenides: Surprising Indirect Gap of Single Layer WSe 2

    KAUST Repository

    Zhang, Chendong

    2015-09-21

    By using a comprehensive form of scanning tunneling spectroscopy, we have revealed detailed quasi-particle electronic structures in transition metal dichalcogenides, including the quasi-particle gaps, critical point energy locations, and their origins in the Brillouin zones. We show that single layer WSe surprisingly has an indirect quasi-particle gap with the conduction band minimum located at the Q-point (instead of K), albeit the two states are nearly degenerate. We have further observed rich quasi-particle electronic structures of transition metal dichalcogenides as a function of atomic structures and spin-orbit couplings. Such a local probe for detailed electronic structures in conduction and valence bands will be ideal to investigate how electronic structures of transition metal dichalcogenides are influenced by variations of local environment.

  5. General Case in Determining Center-To-Center Spacing Between the Screw and the Roller in a Roller Drive, and Initial Contact Point of Their Mating Thread Turns. Development of Calculation Method and Software

    Directory of Open Access Journals (Sweden)

    D. S. Blinov

    2017-01-01

    Full Text Available One of the most important trends in development of machine engineering is to improve load capacity of mechanisms, assemblies and parts without increasing their overall dimensions and weight. This is also relevant to the most promising items so far, i.e. orbital roller drives (ORD, which are the rotational-to-progressive motion converters widely used in vehicles. The previously published article suggested increasing a load capacity (by about 15% through reducing a thread turn section angle of the threaded ORD components and change of the radius of roller thread turn section outline. Due to such ORD modification, a number of the most critical ORD parameters are to be changed thereby demanding further research. Further, the article published suggests a method considering the abovementioned changes to calculate the dimensions of ORD main components and their tolerance ranges.Though this method being not complete as the increment of ORD center-to-center spacing in relation to its rated value, required for assembly, is unknown; and to determine the ORD center-to-center spacing increment, outer diameters of the roller and screw threads are to be known. Hence, these two methods are interconnected.This article presents the numerical calculation method, mathematical support and method to determine the increment of ORD center-to-center spacing and initial contact point of the mating roller and screw thread turns. Due to considerable scope of calculations, the method was turned into the software.Similar calculation methods and techniques were developed to a particular case, where the thread turn section angle of the threaded components was of 90°, and the roller thread turn section outline was a circular arc centered to the roller axis. Hence the developed numerical calculation method, mathematical support and technique refer to the general case which is to determine the ORD center-to-center spacing increment and initial contact point of the mating roller

  6. Efficient Background Segmentation and Seed Point Generation for a Single-Shot Stereo System

    Science.gov (United States)

    Chen, Xiaobo; Xi, Juntong

    2017-01-01

    Single-shot stereo 3D shape measurement is becoming more popular due to its advantages of noise robustness and short acquisition period. One of the key problems is stereo matching, which is related to the efficiency of background segmentation and seed point generation, etc. In this paper, a more efficient and automated matching algorithm based on digital image correlation (DIC) is proposed. The standard deviation of image gradients and an adaptive threshold are employed to segment the background. Scale-invariant feature transform (SIFT)-based feature matching and two-dimensional triangulation are combined to estimate accurate initial parameters for seed point generation. The efficiency of background segmentation and seed point generation, as well as the measuring precision, are evaluated by experimental simulation and real tests. Experimental results show that the average segmentation time for an image with a resolution of 1280 × 960 pixels is 240 milliseconds. The efficiency of seed point generation is verified to be high with different convergence criteria. PMID:29194415

  7. Structure Based Thermostability Prediction Models for Protein Single Point Mutations with Machine Learning Tools.

    Directory of Open Access Journals (Sweden)

    Lei Jia

    Full Text Available Thermostability issue of protein point mutations is a common occurrence in protein engineering. An application which predicts the thermostability of mutants can be helpful for guiding decision making process in protein design via mutagenesis. An in silico point mutation scanning method is frequently used to find "hot spots" in proteins for focused mutagenesis. ProTherm (http://gibk26.bio.kyutech.ac.jp/jouhou/Protherm/protherm.html is a public database that consists of thousands of protein mutants' experimentally measured thermostability. Two data sets based on two differently measured thermostability properties of protein single point mutations, namely the unfolding free energy change (ddG and melting temperature change (dTm were obtained from this database. Folding free energy change calculation from Rosetta, structural information of the point mutations as well as amino acid physical properties were obtained for building thermostability prediction models with informatics modeling tools. Five supervised machine learning methods (support vector machine, random forests, artificial neural network, naïve Bayes classifier, K nearest neighbor and partial least squares regression are used for building the prediction models. Binary and ternary classifications as well as regression models were built and evaluated. Data set redundancy and balancing, the reverse mutations technique, feature selection, and comparison to other published methods were discussed. Rosetta calculated folding free energy change ranked as the most influential features in all prediction models. Other descriptors also made significant contributions to increasing the accuracy of the prediction models.

  8. Detection of Janus Kinase 2 gene single point mutation in real samples with electrochemical DNA biosensor.

    Science.gov (United States)

    Topkaya, Seda Nur; Kosova, Buket; Ozsoz, Mehmet

    2014-02-15

    Janus Kinase 2 (JAK2) gene single point mutations, which have been reported to be associated with myeloproliferative disorders, are usually detected through conventional methods such as melting curve assays, allele-specific and quantitative Polymerase Chain Reactions (PCRs). Herein, an electrochemical biosensor for the detection of a Guanine (G) to Thymine (T) transversion at nucleotide position 1849 of the JAK2 gene was reported. Due to clinical importance of this mutation, easy and sensitive tests are needed to be developed. Our aim was to design a biosensor system that is capable of detecting the mutation within less than 1h with high sensitivity. For these purposes, an electrochemical sensing system was developed based on detecting hybridization. Hybridization between probe and its target and discrimination of single point mutation was investigated by monitoring guanine oxidation signals observed at +1.0 V with Differential Pulse Voltammetry (DPV) by using synthetic oligonucleotides and Polymerase Chain Reaction (PCR) amplicons. Hybridization between probe and PCR amplicons was also determined with Electrochemical Impedance Spectroscopy (EIS). We successfully detect hybridization first in synthetic samples, and ultimately in real samples involving blood samples from patients as well as additional healthy controls. The limit of detection (S/N=3) was calculated as 44 pmol of target sequence in a 40-μl reaction volume in real samples. Copyright © 2013 Elsevier B.V. All rights reserved.

  9. Automatic tracking of vessel-like structures from a single starting point.

    Science.gov (United States)

    Oliveira, Dário Augusto Borges; Leal-Taixé, Laura; Feitosa, Raul Queiroz; Rosenhahn, Bodo

    2016-01-01

    The identification of vascular networks is an important topic in the medical image analysis community. While most methods focus on single vessel tracking, the few solutions that exist for tracking complete vascular networks are usually computationally intensive and require a lot of user interaction. In this paper we present a method to track full vascular networks iteratively using a single starting point. Our approach is based on a cloud of sampling points distributed over concentric spherical layers. We also proposed a vessel model and a metric of how well a sample point fits this model. Then, we implement the network tracking as a min-cost flow problem, and propose a novel optimization scheme to iteratively track the vessel structure by inherently handling bifurcations and paths. The method was tested using both synthetic and real images. On the 9 different data-sets of synthetic blood vessels, we achieved maximum accuracies of more than 98%. We further use the synthetic data-set to analyze the sensibility of our method to parameter setting, showing the robustness of the proposed algorithm. For real images, we used coronary, carotid and pulmonary data to segment vascular structures and present the visual results. Still for real images, we present numerical and visual results for networks of nerve fibers in the olfactory system. Further visual results also show the potential of our approach for identifying vascular networks topologies. The presented method delivers good results for the several different datasets tested and have potential for segmenting vessel-like structures. Also, the topology information, inherently extracted, can be used for further analysis to computed aided diagnosis and surgical planning. Finally, the method's modular aspect holds potential for problem-oriented adjustments and improvements. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. Real-Time Single Frequency Precise Point Positioning Using SBAS Corrections

    Directory of Open Access Journals (Sweden)

    Liang Li

    2016-08-01

    Full Text Available Real-time single frequency precise point positioning (PPP is a promising technique for high-precision navigation with sub-meter or even centimeter-level accuracy because of its convenience and low cost. The navigation performance of single frequency PPP heavily depends on the real-time availability and quality of correction products for satellite orbits and satellite clocks. Satellite-based augmentation system (SBAS provides the correction products in real-time, but they are intended to be used for wide area differential positioning at 1 meter level precision. By imposing the constraints for ionosphere error, we have developed a real-time single frequency PPP method by sufficiently utilizing SBAS correction products. The proposed PPP method are tested with static and kinematic data, respectively. The static experimental results show that the position accuracy of the proposed PPP method can reach decimeter level, and achieve an improvement of at least 30% when compared with the traditional SBAS method. The positioning convergence of the proposed PPP method can be achieved in 636 epochs at most in static mode. In the kinematic experiment, the position accuracy of the proposed PPP method can be improved by at least 20 cm relative to the SBAS method. Furthermore, it has revealed that the proposed PPP method can achieve decimeter level convergence within 500 s in the kinematic mode.

  11. From single point of measurement to distributed sensing in long-term glacier monitoring

    International Nuclear Information System (INIS)

    Cesarini, Daniel; Avvenuti, Marco; Jelicic, Vana; Bilas, Vedran

    2013-01-01

    Glacial environment monitoring is a key task in understanding natural phenomena related to global warming. For the last 30 years, Automatic Weather Stations (AWSs) have been spreading among the meteorological and geophysical community, and are on the way to become a de facto standard to perform long-lasting unattended data acquisitions in single localized points of interest. Sensor Networks (SNs), on the other hand, promise the possibility to perform measurements with a higher spatial density and lower cost. Designing and developing a SN for glacial environment face particular challenges for embedded electronics and sensor systems, which is why SNs are still under research and development in this field. This paper surveys the AWSs and SNs for glacial monitoring applications and compares their characteristics.

  12. Simulation study based on the single-point temperature monitoring system of LabVIEW

    Science.gov (United States)

    Wu, Yongling; Yang, Na; Liu, Shuping; Pan, Xiaohui; Wang, Wenjiang

    2014-12-01

    This paper takes LabVIEW2012 as a development platform, creating a J-type thermocouple sensor and the NI USB-6229 data acquisition card and other hardware emulation circuitry which combined with the PC designed a single-point temperature monitoring system. Through simulation experiments, the system has a collection interval, the sampling rate per channel sampling on the temperature limit set by the user function and it also has the function of real-time display the current temperature, the temperature limit alarm, maximum temperature, minimum temperature display and a temperature history data query. This system can be used for temperature monitoring of life, research, industrial control, environmental monitoring, biomedical, tobacco processing, greenhouse cultivation, livestock breeding and other fields, which has important significance and practical value.

  13. Plastic flow and failure in single point incremental forming of PVC sheets

    Directory of Open Access Journals (Sweden)

    P. A. F. Martins

    2014-05-01

    Full Text Available This paper presents an innovative and effective methodology to characterize plastic flow and failure in single point incremental forming (SPIF of polymers that allows determining the stresses and the accumulated values of ductile damage directly from the experimental values of strain at various positions over the deformed polymer sheets. The approach traces the deformation path of material elements in conical and pyramidal SPIF parts, undergoing linear strain loading paths from beginning until failure, and is built upon the generalization of the analytical framework conditions assumed by Glover et al. [1] to the pressure-sensitive yield surfaces of polymers under incompressible, non-associated, plastic flow. Experimentation in conventional and multi-stage SPIF of Polyvinylchloride (PVC sheets confirms the effectiveness of the proposed methodology and demonstrates that standard non-coupled damage models currently utilized in sheet metal forming are inapplicable to describe failure in polymers. Instead fracture forming limit lines (FFL’s should be employed.

  14. A single quantum dot-based biosensor for DNA point mutation assay.

    Science.gov (United States)

    Tang, Wei; Zhu, Guichi; Liang, Li; Zhang, Chun-Yang

    2015-09-07

    Sensitive and selective detection of point mutation is essential to molecular biology research and early clinical diagnosis. Here, we demonstrate a single quantum dot (QD)-based biosensor for DNA point mutation assay. In this assay, a mutant target (G/C) remains unchanged after the endonuclease treatment, and the polymerase chain reaction (PCR) may be initiated with the assistance of primers and polymerase, generating a large number of mutant targets. The amplified mutant targets can be captured by biotinylated probes during the process of denaturation and annealing, and Cy5-dGTP may be assembled into the biotinylated probe with the catalysis of polymerase, leading to the formation of Cy5-labeled biotinylated probes. The Cy5-labeled biotinylated probes can be further assembled onto the QD surface to obtain a Cy5-DNA-QD complex, resulting in the generation of fluorescence resonance energy transfer (FRET) between the QD donor and the Cy5 receptor. The mutant targets can be quantitatively evaluated by the measurement of Cy5 counts by total internal reflection fluorescence (TIRF) microscopy. While in the presence of wild-type targets (T/A), no Cy5-dGTP can be assembled into the biotinylated probe due to the presence of a mismatch and consequently no FRET is observed. This single QD-based biosensor exhibits high sensitivity with a detection limit of 5.3 aM (or 32 copies) and can even discriminate as low as 0.01% variant frequency from the mixture of mutant targets and wild-type ones. Importantly, this biosensor can be used for genomic analysis in human lung cancer cells, and may be further applied for an early clinical diagnosis and personalized medicine.

  15. Monitoring single event upsets in SRAM-based FPGAs at the SuperKEKB interaction point

    Science.gov (United States)

    Giordano, R.; Tortone, G.; Perrella, S.; Izzo, V.; Aloisio, A.

    2017-07-01

    In February 2016, the SuperKEKB positron-electron high-luminosity collider of the KEK laboratory (Tsukuba, Japan) started being commissioned. A dedicated commissioning detector, named BEAST2, has been used to characterize beam backgrounds before the Belle2 detector was rolled into the beams and to provide tuning parameters for Monte Carlo simulations. BEAST2 consists of a fiberglass support structure and several sub-detectors mounted onto it, including time projection chambers (TPCs) and He-3 tubes. In this work, we present direct measurements of radiation-induced single event upsets in a SRAM-based FPGA device installed in BEAST2 at a distance of ~ 1 m from the beam interaction point. Our goal was to provide experimental results of the expected radiation-induced configuration upset rate and power consumption variation at Belle2 and at other experiments operating in similar radiation environments. Beam currents for both electron and positron rings spanned a range between 50 and 500 mA, therefore providing data about the FPGA operation in different radiation conditions. Even if the machine has not been providing collisions yet, as the beams were not focused to the interaction point, our results show a rate of 0.15 upsets/day averaged over the whole commissioning time frame. We had neither evidence of total dose effects on the FPGA power consumption nor of permanent damage to the device.

  16. Spherical Projection Based Straight Line Segment Extraction for Single Station Terrestrial Laser Point Cloud

    Directory of Open Access Journals (Sweden)

    ZHANG Fan

    2015-06-01

    Full Text Available Due to the discrete distribution computing errors and lack of adaptability are ubiquitous in the current straight line extraction for TLS data methods. A 3D straight line segment extraction method is proposed based on spherical projection for single station terrestrial laser point clouds. Firstly, horizontal and vertical angles of each laser point are calculated by means of spherical coordinates, intensity panoramic image according to the two angles is generated. Secondly, edges which include straight line features are detected from intensity panoramic image by using of edge detection algorithm. Thirdly, great circles are detected from edges of panoramic image using spherical Hough transform. According to the axiom that a straight line segment in 3D space is a spherical great circle after spherical projection, detecting great circles from spherical projected data sets is essentially detecting straight line segments from 3D data sets without spherical projection. Finally, a robust 3D straight line fitting method is employed to fitting the straight lines and calculating parameters of the straight line segments. Experiments using different data sets and comparison with other methods show the accuracy and applicability of the proposed method.

  17. Sensor system for multi-point monitoring using bending loss of single mode optical fiber

    International Nuclear Information System (INIS)

    Kim, Heon Young; Kim, Dae Hyun

    2015-01-01

    Applications of smart sensors have been extended to safety systems in the aerospace, transportation and civil engineering fields. In particular, structural health monitoring techniques using smart sensors have gradually become necessary and have been developed to prevent dangers to human life and damage to assets. Generally, smart sensors are based on electro-magnets and have several weaknesses, including electro-magnetic interference and distortion. Therefore, fiber optic sensors are an outstanding alternative to overcome the weaknesses of electro-magnetic sensors. However, they require expensive devices and complex systems. This paper proposes a new, affordable and simple sensor system that uses a single fiber to monitor pressures at multiple-points. Moreover, a prototype of the sensor system was manufactured and tested for a feasibility study. Based on the results of this experimental test, a relationship was carefully observed between the bend loss conditions and light-intensity. As a result, it was shown that impacts at multiple-points could be monitored.

  18. Criteria for evaluating protection from single points of failure for partially expanded fault trees

    International Nuclear Information System (INIS)

    Aswani, D.; Badreddine, B.; Malone, M.; Gauthier, G.; Proietty, J.

    2008-01-01

    Fault tree analysis (FTA) is a technique that describes the combinations of events in a system which result in an undesirable outcome. FTA is used as a tool to quantitatively assess a system's probability for an undesirable outcome. Time constraints from concept to production in modern engineering often limit the opportunity for a thorough statistical analysis of a system. Furthermore, when undesirable outcomes are considered such as hazard to human(s), it becomes difficult to identify strict statistical targets for what is acceptable. Consequently, when hazard to human(s) is concerned a common design target is to protect the system from single points of failure (SPOF) which means that no failure mode caused by a single event, concern, or error has a critical consequence on the system. Such a design target is common with 'by-wire' systems. FTA can be used to verify if a system is protected from SPOF. In this paper, sufficient criteria for evaluating protection from SPOF for partially expanded fault trees are proposed along with proof. The proposed criteria consider potential interactions between the lowest drawn events of a partial fault tree expansion which otherwise easily leads to an overly optimistic analysis of protection from SPOF. The analysis is limited to fault trees that are coherent and static

  19. Analysis of Point Based Image Registration Errors With Applications in Single Molecule Microscopy.

    Science.gov (United States)

    Cohen, E A K; Ober, R J

    2013-12-15

    We present an asymptotic treatment of errors involved in point-based image registration where control point (CP) localization is subject to heteroscedastic noise; a suitable model for image registration in fluorescence microscopy. Assuming an affine transform, CPs are used to solve a multivariate regression problem. With measurement errors existing for both sets of CPs this is an errors-in-variable problem and linear least squares is inappropriate; the correct method being generalized least squares. To allow for point dependent errors the equivalence of a generalized maximum likelihood and heteroscedastic generalized least squares model is achieved allowing previously published asymptotic results to be extended to image registration. For a particularly useful model of heteroscedastic noise where covariance matrices are scalar multiples of a known matrix (including the case where covariance matrices are multiples of the identity) we provide closed form solutions to estimators and derive their distribution. We consider the target registration error (TRE) and define a new measure called the localization registration error (LRE) believed to be useful, especially in microscopy registration experiments. Assuming Gaussianity of the CP localization errors, it is shown that the asymptotic distribution for the TRE and LRE are themselves Gaussian and the parameterized distributions are derived. Results are successfully applied to registration in single molecule microscopy to derive the key dependence of the TRE and LRE variance on the number of CPs and their associated photon counts. Simulations show asymptotic results are robust for low CP numbers and non-Gaussianity. The method presented here is shown to outperform GLS on real imaging data.

  20. Evaluations of Three-Dimensional Building Model Reconstruction from LiDAR Point Clouds and Single-View Perspective Imagery

    Directory of Open Access Journals (Sweden)

    F. Tsai

    2014-06-01

    Full Text Available This paper briefly presents two approaches for effective three-dimensional (3D building model reconstruction from terrestrial laser scanning (TLS data and single perspective view imagery and assesses their applicability to the reconstruction of 3D models of landmark or historical buildings. The collected LiDAR point clouds are registered based on conjugate points identified using a seven-parameter transformation system. Three dimensional models are generated using plan and surface fitting algorithms. The proposed single-view reconstruction (SVR method is based on vanishing points and single-view metrology. More detailed models can also be generated according to semantic analysis of the façade images. Experimental results presented in this paper demonstrate that both TLS and SVR approaches can successfully produce accurate and detailed 3D building models from LiDAR point clouds or different types of single-view perspective images.

  1. Migration as a turning point in food habits: the early phase of dietary acculturation among women from South Asian, African, and Middle Eastern Countries living in Norway.

    Science.gov (United States)

    Terragni, Laura; Garnweidner, Lisa M; Pettersen, Kjell Sverre; Mosdøl, Annhild

    2014-01-01

    This article explores the early phase of dietary acculturation after migration. South Asian, African and Middle Eastern women (N = 21) living in Norway were interviewed about their early experiences with food in a new context. The findings pointed to abrupt changes in food habits in the first period after migration. To various degrees, women reported unfamiliarity with foods in shops, uncertainty about meal formats and food preparation and fear of eating food prohibited by their religion. Their food consumption tended to be restricted to food items perceived as familiar or safe. Our findings indicate that the first period after migration represents a specific phase in the process of dietary acculturation. Early initiatives aimed at enhancing confidence in food and familiarity with the new food culture are recommended.

  2. Heraclitean logos and flux in T.S. Eliot’s Four Quartets: 'cosmic consciousness' and 'the still point of the turning world'

    Directory of Open Access Journals (Sweden)

    A. Wessels

    2001-08-01

    Full Text Available T.S. Eliot prefaces “Burnt Norton”, the first of his Four Quartets, with two quotations from the Greek philosopher, Heraclitus. By means of these epigrams, Eliot points us to the Heraclitean opposition and paradoxical interdependence between logos and flux as a paradigm in the poem, a paradigm that he uses for an investigation and articulation of a number of philosophical contemplations. In this paper, I discuss Eliot’s different configurations of the logos/flux paradigm in the poem, firstly to illuminate the relationship between temporality and eternity, secondly, to elaborate the relationship between God and humanity, and thirdly to express the relationship between structured art and chaotic experience. In each instance it is not only the opposition between the two elements that is important, but also the point of contact, the intersection. There is some evidence that Eliot’s depiction of this intersection as, for example, the “moment in and out of time”, is based on personal experience of a transcendent, mystical nature. His expression of this experience is also investigated by comparing it to similar experiences described by others, notably by a Canadian psychiatrist, Richard Maurice Bucke. A comparison of Bucke’s description in his evolutionist text of 1901 and Eliot’s poetic rendering reveals not only surprising similarities but also essential differences which highlights Eliot’s purely Christian interpretation in the face of Bucke’s more universalist approach. For T.S. Eliot, eternity or timelessness can only be accessed through the temporal experience of human consciousness, in fleeting moments of exaltation in daily life, in the charged, timeless configurations of art as an imitation of divine creation, and finally in Christ, who embodies the love of God and is for Eliot the ultimate transection of the temporal and eternal, the flux and the logos.

  3. Towards single-valued polylogarithms in two variables for the seven-point remainder function in multi-Regge kinematics

    Directory of Open Access Journals (Sweden)

    Johannes Broedel

    2017-02-01

    Full Text Available We investigate single-valued polylogarithms in two complex variables, which are relevant for the seven-point remainder function in N=4 super-Yang–Mills theory in the multi-Regge regime. After constructing these two-dimensional polylogarithms, we determine the leading logarithmic approximation of the seven-point remainder function up to and including five loops.

  4. Femtosecond few- to single-electron point-projection microscopy for nanoscale dynamic imaging

    Science.gov (United States)

    Bainbridge, A. R.; Barlow Myers, C. W.; Bryan, W. A.

    2016-01-01

    Femtosecond electron microscopy produces real-space images of matter in a series of ultrafast snapshots. Pulses of electrons self-disperse under space-charge broadening, so without compression, the ideal operation mode is a single electron per pulse. Here, we demonstrate femtosecond single-electron point projection microscopy (fs-ePPM) in a laser-pump fs-e-probe configuration. The electrons have an energy of only 150 eV and take tens of picoseconds to propagate to the object under study. Nonetheless, we achieve a temporal resolution with a standard deviation of 114 fs (equivalent to a full-width at half-maximum of 269 ± 40 fs) combined with a spatial resolution of 100 nm, applied to a localized region of charge at the apex of a nanoscale metal tip induced by 30 fs 800 nm laser pulses at 50 kHz. These observations demonstrate real-space imaging of reversible processes, such as tracking charge distributions, is feasible whilst maintaining femtosecond resolution. Our findings could find application as a characterization method, which, depending on geometry, could resolve tens of femtoseconds and tens of nanometres. Dynamically imaging electric and magnetic fields and charge distributions on sub-micron length scales opens new avenues of ultrafast dynamics. Furthermore, through the use of active compression, such pulses are an ideal seed for few-femtosecond to attosecond imaging applications which will access sub-optical cycle processes in nanoplasmonics. PMID:27158637

  5. Femtosecond few- to single-electron point-projection microscopy for nanoscale dynamic imaging

    Directory of Open Access Journals (Sweden)

    A. R. Bainbridge

    2016-03-01

    Full Text Available Femtosecond electron microscopy produces real-space images of matter in a series of ultrafast snapshots. Pulses of electrons self-disperse under space-charge broadening, so without compression, the ideal operation mode is a single electron per pulse. Here, we demonstrate femtosecond single-electron point projection microscopy (fs-ePPM in a laser-pump fs-e-probe configuration. The electrons have an energy of only 150 eV and take tens of picoseconds to propagate to the object under study. Nonetheless, we achieve a temporal resolution with a standard deviation of 114 fs (equivalent to a full-width at half-maximum of 269 ± 40 fs combined with a spatial resolution of 100 nm, applied to a localized region of charge at the apex of a nanoscale metal tip induced by 30 fs 800 nm laser pulses at 50 kHz. These observations demonstrate real-space imaging of reversible processes, such as tracking charge distributions, is feasible whilst maintaining femtosecond resolution. Our findings could find application as a characterization method, which, depending on geometry, could resolve tens of femtoseconds and tens of nanometres. Dynamically imaging electric and magnetic fields and charge distributions on sub-micron length scales opens new avenues of ultrafast dynamics. Furthermore, through the use of active compression, such pulses are an ideal seed for few-femtosecond to attosecond imaging applications which will access sub-optical cycle processes in nanoplasmonics.

  6. Obtaining Global Picture From Single Point Observations by Combining Data Assimilation and Machine Learning Tools

    Science.gov (United States)

    Shprits, Y.; Zhelavskaya, I. S.; Kellerman, A. C.; Spasojevic, M.; Kondrashov, D. A.; Ghil, M.; Aseev, N.; Castillo Tibocha, A. M.; Cervantes Villa, J. S.; Kletzing, C.; Kurth, W. S.

    2017-12-01

    Increasing volume of satellite measurements requires deployment of new tools that can utilize such vast amount of data. Satellite measurements are usually limited to a single location in space, which complicates the data analysis geared towards reproducing the global state of the space environment. In this study we show how measurements can be combined by means of data assimilation and how machine learning can help analyze large amounts of data and can help develop global models that are trained on single point measurement. Data Assimilation: Manual analysis of the satellite measurements is a challenging task, while automated analysis is complicated by the fact that measurements are given at various locations in space, have different instrumental errors, and often vary by orders of magnitude. We show results of the long term reanalysis of radiation belt measurements along with fully operational real-time predictions using data assimilative VERB code. Machine Learning: We present application of the machine learning tools for the analysis of NASA Van Allen Probes upper-hybrid frequency measurements. Using the obtained data set we train a new global predictive neural network. The results for the Van Allen Probes based neural network are compared with historical IMAGE satellite observations. We also show examples of predictions of geomagnetic indices using neural networks. Combination of machine learning and data assimilation: We discuss how data assimilation tools and machine learning tools can be combine so that physics-based insight into the dynamics of the particular system can be combined with empirical knowledge of it's non-linear behavior.

  7. Is equilibrium point control feasible for fast goal-directed single-joint movements?

    Science.gov (United States)

    Kistemaker, Dinant A; Van Soest, Arthur J; Bobbert, Maarten F

    2006-05-01

    Several types of equilibrium point (EP) controllers have been proposed for the control of posture and movement. EP controllers are appealing from a computational perspective because they do not require solving the "inverse dynamic problem" (i.e., computation of the torques required to move a system along a desired trajectory). It has been argued that EP controllers are not capable of controlling fast single-joint movements. To refute this statement, several extensions have been proposed, although these have been tested using models in which only the tendon compliance, force-length-velocity relation, and mechanical interaction between tendon and contractile element were not adequately represented. In the present study, fast elbow-joint movements were measured and an attempt was made to reproduce these using a realistic musculoskeletal model of the human arm. Three types of EP controllers were evaluated: an open-loop alpha-controller, a closed-loop lambda-controller, and a hybrid open- and closed-loop controller. For each controller we considered a continuous version and a version in which the control signals were sent out intermittently. Only the intermittent hybrid EP controller was capable of generating movements that were as fast as those of the subjects. As a result of the nonlinear muscle properties, the hybrid EP controller requires a more detailed representation of static muscle properties than generally assumed in the context of EP control. In sum, this study shows that fast single-joint movements can be realized without explicitly solving the inverse dynamics problem, but in a less straightforward manner than implied by proponents of conventional EP controllers.

  8. Prediction and control of pillow defect in single point incremental forming using numerical simulations

    Energy Technology Data Exchange (ETDEWEB)

    Isidore, B. B. Lemopi [Eastern Mediterranean University, Gazimagusa (Turkmenistan); Hussain, G.; Khan, Wasim A. [GIK Institute of Engineering, Swabi (Pakistan); Shamachi, S. Pourhassan [University of Minho, Guimaraes (Portugal)

    2016-05-15

    Pillows formed at the center of sheets in Single point incremental forming (SPIF) are fabrication defects which adversely affect the geometrical accuracy and formability of manufactured parts. This study is focused on using FEA as a tool to predict and control pillowing in SPIF by varying tool size and shape. 3D Finite element analysis (FEA) and experiments are carried out using annealed Aluminum 1050. From FEA, it is found out that the stress/strain state in the immediate vicinity of the forming tool in the transverse direction plays a determinant role on sheet pillowing. Furthermore, pillow height increases as compression in the sheet-plane increases. The nature of in-plane stresses in the transverse direction varies from compressive to tensile as the tool-end geometry is changed from spherical to flat. Additionally, the magnitude of corresponding in-plane stresses decreases as the tool radius increases. According to measurements from the FEA model, flat end tools and large radii both retard pillow formation. However, the influence of changing tool end shape from hemispherical to flat is observed to be more important than the effect of varying tool radius, because the deformation zone remains in tension in the transverse direction while forming with flat end tools. These findings are verified by conducting a set of experiments. A fair agreement between the FEM and empirical results show that FEM can be employed as a tool to predict and control the pillow defect in SPIF.

  9. Pan European Phenological database (PEP725): a single point of access for European data

    Science.gov (United States)

    Templ, Barbara; Koch, Elisabeth; Bolmgren, Kjell; Ungersböck, Markus; Paul, Anita; Scheifinger, Helfried; Rutishauser, This; Busto, Montserrat; Chmielewski, Frank-M.; Hájková, Lenka; Hodzić, Sabina; Kaspar, Frank; Pietragalla, Barbara; Romero-Fresneda, Ramiro; Tolvanen, Anne; Vučetič, Višnja; Zimmermann, Kirsten; Zust, Ana

    2018-02-01

    The Pan European Phenology (PEP) project is a European infrastructure to promote and facilitate phenological research, education, and environmental monitoring. The main objective is to maintain and develop a Pan European Phenological database (PEP725) with an open, unrestricted data access for science and education. PEP725 is the successor of the database developed through the COST action 725 "Establishing a European phenological data platform for climatological applications" working as a single access point for European-wide plant phenological data. So far, 32 European meteorological services and project partners from across Europe have joined and supplied data collected by volunteers from 1868 to the present for the PEP725 database. Most of the partners actively provide data on a regular basis. The database presently holds almost 12 million records, about 46 growing stages and 265 plant species (including cultivars), and can be accessed via http://www.pep725.eu/. Users of the PEP725 database have studied a diversity of topics ranging from climate change impact, plant physiological question, phenological modeling, and remote sensing of vegetation to ecosystem productivity.

  10. Pan European Phenological database (PEP725): a single point of access for European data.

    Science.gov (United States)

    Templ, Barbara; Koch, Elisabeth; Bolmgren, Kjell; Ungersböck, Markus; Paul, Anita; Scheifinger, Helfried; Rutishauser, This; Busto, Montserrat; Chmielewski, Frank-M; Hájková, Lenka; Hodzić, Sabina; Kaspar, Frank; Pietragalla, Barbara; Romero-Fresneda, Ramiro; Tolvanen, Anne; Vučetič, Višnja; Zimmermann, Kirsten; Zust, Ana

    2018-02-18

    The Pan European Phenology (PEP) project is a European infrastructure to promote and facilitate phenological research, education, and environmental monitoring. The main objective is to maintain and develop a Pan European Phenological database (PEP725) with an open, unrestricted data access for science and education. PEP725 is the successor of the database developed through the COST action 725 "Establishing a European phenological data platform for climatological applications" working as a single access point for European-wide plant phenological data. So far, 32 European meteorological services and project partners from across Europe have joined and supplied data collected by volunteers from 1868 to the present for the PEP725 database. Most of the partners actively provide data on a regular basis. The database presently holds almost 12 million records, about 46 growing stages and 265 plant species (including cultivars), and can be accessed via http://www.pep725.eu/ . Users of the PEP725 database have studied a diversity of topics ranging from climate change impact, plant physiological question, phenological modeling, and remote sensing of vegetation to ecosystem productivity.

  11. Mental Health Conditions and Symptoms in Pediatric Hospitalizations: A Single-Center Point Prevalence Study.

    Science.gov (United States)

    Doupnik, Stephanie K; Henry, M Katherine; Bae, Hanah; Litman, Jessica; Turner, Shanarra; Scharko, Alexander M; Feudtner, Chris

    2017-03-01

    Children and adolescents necessitating hospitalization for physical health conditions are at high risk for mental health conditions; however, the prevalence of mental health conditions and symptoms among hospitalized children and adolescents is uncertain. The objective of this study was to determine the proportion of hospitalized children and adolescents who have diagnosed mental health disorders or undiagnosed mental health problems. In this single-center point prevalence study of hospitalized children between the ages of 4 and 21 years, patients or their parents reported known mental health diagnoses and use of services using the Services Assessment for Children and Adolescent, and they reported patient mental health symptoms using the Pediatric Symptom Checklist, 17-item form (PSC-17). Of 229 eligible patients, 119 agreed to participate. Demographic characteristics of patients who enrolled were not statistically significantly different from those of patients who declined to participate. Among participants, 26% (95% confidence interval [CI], 18%-35%) reported a known mental health diagnosis. On the PSC-17, 29% (95% CI, 21%-38%) of participants had a positive screen for mental health symptoms. Of those with a positive screen, 38% (95% CI, 21%-55%) had no known mental health diagnosis, and 26% (95% CI, 12%-43%) had not received ambulatory mental health services in the 12 months before hospitalization. Mental health conditions and symptoms are common among patients hospitalized in a tertiary children's hospital, and many affected patients are not receiving ambulatory mental health services. Copyright © 2016 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved.

  12. Estimating Uncertainty of Point-Cloud Based Single-Tree Segmentation with Ensemble Based Filtering

    Directory of Open Access Journals (Sweden)

    Matthew Parkan

    2018-02-01

    Full Text Available Individual tree crown segmentation from Airborne Laser Scanning data is a nodal problem in forest remote sensing. Focusing on single layered spruce and fir dominated coniferous forests, this article addresses the problem of directly estimating 3D segment shape uncertainty (i.e., without field/reference surveys, using a probabilistic approach. First, a coarse segmentation (marker controlled watershed is applied. Then, the 3D alpha hull and several descriptors are computed for each segment. Based on these descriptors, the alpha hulls are grouped to form ensembles (i.e., groups of similar tree shapes. By examining how frequently regions of a shape occur within an ensemble, it is possible to assign a shape probability to each point within a segment. The shape probability can subsequently be thresholded to obtain improved (filtered tree segments. Results indicate this approach can be used to produce segmentation reliability maps. A comparison to manually segmented tree crowns also indicates that the approach is able to produce more reliable tree shapes than the initial (unfiltered segmentation.

  13. Single point incremental sheet forming investigated by in-process 3D digital image correlation

    Directory of Open Access Journals (Sweden)

    Bernhart G.

    2010-06-01

    Full Text Available Single Point Incremental Forming (SPIF is a promising sheet metal forming process for prototyping and small batches, in which the blank is formed in a stepwise fashion by a displacement-controlled small-sized tool. Due to specific strain paths induced by the process and limited plastic zones in the contact region between the tool and the workpiece, forming diagrams and forming strategies are different from the classical stamping processes. One major limitation of SPIF is the lack of accuracy of the obtained final parts because of the poor knowledge of the state of stress during the process that requires a good description of the material models and a right choice of the process parameters. In this paper, the SPIF process is experimentally investigated by the mean of surface 3D digital image correlation during the forming of a AW-5086-H111 grade aluminium alloy. Development of strain fields encountered in incremental forming is reported and material formability is evaluated on several formed shapes, taking into account a wide range of straining conditions of this process.

  14. Single point incremental sheet forming investigated by in-process 3D digital image correlation

    Science.gov (United States)

    Decultot, N.; Robert, L.; Velay, V.; Bernhart, G.

    2010-06-01

    Single Point Incremental Forming (SPIF) is a promising sheet metal forming process for prototyping and small batches, in which the blank is formed in a stepwise fashion by a displacement-controlled small-sized tool. Due to specific strain paths induced by the process and limited plastic zones in the contact region between the tool and the workpiece, forming diagrams and forming strategies are different from the classical stamping processes. One major limitation of SPIF is the lack of accuracy of the obtained final parts because of the poor knowledge of the state of stress during the process that requires a good description of the material models and a right choice of the process parameters. In this paper, the SPIF process is experimentally investigated by the mean of surface 3D digital image correlation during the forming of a AW-5086-H111 grade aluminium alloy. Development of strain fields encountered in incremental forming is reported and material formability is evaluated on several formed shapes, taking into account a wide range of straining conditions of this process.

  15. Prediction and control of pillow defect in single point incremental forming using numerical simulations

    International Nuclear Information System (INIS)

    Isidore, B. B. Lemopi; Hussain, G.; Khan, Wasim A.; Shamachi, S. Pourhassan

    2016-01-01

    Pillows formed at the center of sheets in Single point incremental forming (SPIF) are fabrication defects which adversely affect the geometrical accuracy and formability of manufactured parts. This study is focused on using FEA as a tool to predict and control pillowing in SPIF by varying tool size and shape. 3D Finite element analysis (FEA) and experiments are carried out using annealed Aluminum 1050. From FEA, it is found out that the stress/strain state in the immediate vicinity of the forming tool in the transverse direction plays a determinant role on sheet pillowing. Furthermore, pillow height increases as compression in the sheet-plane increases. The nature of in-plane stresses in the transverse direction varies from compressive to tensile as the tool-end geometry is changed from spherical to flat. Additionally, the magnitude of corresponding in-plane stresses decreases as the tool radius increases. According to measurements from the FEA model, flat end tools and large radii both retard pillow formation. However, the influence of changing tool end shape from hemispherical to flat is observed to be more important than the effect of varying tool radius, because the deformation zone remains in tension in the transverse direction while forming with flat end tools. These findings are verified by conducting a set of experiments. A fair agreement between the FEM and empirical results show that FEM can be employed as a tool to predict and control the pillow defect in SPIF.

  16. The use of single point incremental forming for customized implants of unicondylar knee arthroplasty: a review

    Directory of Open Access Journals (Sweden)

    Pankaj Kailasrao Bhoyar

    Full Text Available Abstract Introduction The implantable devices are having enormous market. These products are basically made by traditional manufacturing process, but for the custom-made implants Incremental Sheet Forming is a paramount alternative. Single Point Incremental Forming (SPIF is a manufacturing process to form intricate, asymmetrical components. It forms the component using stretching and bending by maintaining materials crystal structure. SPIF process can be performed using conventional Computer Numerical Control (CNC milling machine. Review This review paper elaborates the various manufacturing processes carried on various biocompatible metallic and nonmetallic customised implantable devices. Conclusion Ti-6Al-4V alloy is broadly used for biomedical implants, but in this alloy, Vanadium is toxic so this alloy is not compatible for implants. The attention of researchers is towards the non toxic and suitable biocompatible materials. For this reason, a novel approach was developed in order to enhance the mechanical properties of this material. . The development of incremental forming technique can improve the formability of existing alloys and may meet the current strict requirements for performance of dies and punches.

  17. Modeling and optimization of surface roughness in single point incremental forming process

    Directory of Open Access Journals (Sweden)

    Suresh Kurra

    2015-07-01

    Full Text Available Single point incremental forming (SPIF is a novel and potential process for sheet metal prototyping and low volume production applications. This article is focuses on the development of predictive models for surface roughness estimation in SPIF process. Surface roughness in SPIF has been modeled using three different techniques namely, Artificial Neural Networks (ANN, Support Vector Regression (SVR and Genetic Programming (GP. In the development of these predictive models, tool diameter, step depth, wall angle, feed rate and lubricant type have been considered as model variables. Arithmetic mean surface roughness (Ra and maximum peak to valley height (Rz are used as response variables to assess the surface roughness of incrementally formed parts. The data required to generate, compare and evaluate the proposed models have been obtained from SPIF experiments performed on Computer Numerical Control (CNC milling machine using Box–Behnken design. The developed models are having satisfactory goodness of fit in predicting the surface roughness. Further, the GP model has been used for optimization of Ra and Rz using genetic algorithm. The optimum process parameters for minimum surface roughness in SPIF have been obtained and validated with the experiments and found highly satisfactory results within 10% error.

  18. Readout of a single electron spin in a double quantum dot using a quantum point contact

    International Nuclear Information System (INIS)

    Zhang Jianping; Ouyang Shihua; You, J Q; Lam, C.-H.

    2008-01-01

    We study the dynamics of a single electron spin in a double quantum dot (DQD) and its readout via a quantum point contact (QPC). We model the system microscopically and derive rate equations for the reduced electron density matrix of the DQD. Two cases with one and two electrons in the DQD are studied. In the one-electron case, with different Zeeman splittings in the two dots, the electron spin states are distinctly characterized by a constant and an oscillatory current through the QPC. In the two-electron case, the readout of the spin state of the electron in one of the dots called the qubit dot is essentially similar after considering hyperfine interactions between the electrons and the nuclear spins of the host materials and a uniform magnetic field applied to the DQD. Moreover, to ensure that an electron is properly injected into the qubit dot, we propose to determine the success of the electron injection from the variations of the QPC current after applying an oscillating magnetic field to the qubit dot

  19. State-of-health monitoring of 18650 4S packs with a single-point impedance diagnostic

    Science.gov (United States)

    Love, Corey T.; Virji, Maheboob B. V.; Rocheleau, Richard E.; Swider-Lyons, Karen E.

    2014-11-01

    The state-of-health (SOH) of Li-ion batteries and battery packs must be monitored effectively for abuse to prevent failure and accidents. In a previous publication, we described a single-point impedance diagnostic method for detecting damage in single prismatic lithium polymer rechargeable cells subjected to overcharge abuse. We now determine whether the single-point impedance diagnostic method is applicable to 4S battery packs. At 316 Hz, commercial 18650 LiCoO2 cells are determined to have the least change in impedance response when cycled between 3.0 and 4.2 V, for states-of-charge (SOC) of 0-100%. The impedance response of single cells at 316 Hz changes dramatically during overcharge (SOC = 125%), presumably due to change in their solid electrolyte interface (SEI) layers at the electrodes. When a single cell is purposely subjected to such overcharge abuse and then integrated into a 4S pack with 3 other healthy cells, the impedance response of the 4S pack at 316 Hz also changes, despite variances in the impedance response of each of the 3 healthy cells. The results suggest that this single-point impedance method could serve as a diagnostic in an all-inclusive battery management system to identify overcharge abuse of single cells without individual cell monitoring.

  20. Detection of Single Tree Stems in Forested Areas from High Density ALS Point Clouds Using 3d Shape Descriptors

    Science.gov (United States)

    Amiri, N.; Polewski, P.; Yao, W.; Krzystek, P.; Skidmore, A. K.

    2017-09-01

    Airborne Laser Scanning (ALS) is a widespread method for forest mapping and management purposes. While common ALS techniques provide valuable information about the forest canopy and intermediate layers, the point density near the ground may be poor due to dense overstory conditions. The current study highlights a new method for detecting stems of single trees in 3D point clouds obtained from high density ALS with a density of 300 points/m2. Compared to standard ALS data, due to lower flight height (150-200 m) this elevated point density leads to more laser reflections from tree stems. In this work, we propose a three-tiered method which works on the point, segment and object levels. First, for each point we calculate the likelihood that it belongs to a tree stem, derived from the radiometric and geometric features of its neighboring points. In the next step, we construct short stem segments based on high-probability stem points, and classify the segments by considering the distribution of points around them as well as their spatial orientation, which encodes the prior knowledge that trees are mainly vertically aligned due to gravity. Finally, we apply hierarchical clustering on the positively classified segments to obtain point sets corresponding to single stems, and perform ℓ1-based orthogonal distance regression to robustly fit lines through each stem point set. The ℓ1-based method is less sensitive to outliers compared to the least square approaches. From the fitted lines, the planimetric tree positions can then be derived. Experiments were performed on two plots from the Hochficht forest in Oberösterreich region located in Austria.We marked a total of 196 reference stems in the point clouds of both plots by visual interpretation. The evaluation of the automatically detected stems showed a classification precision of 0.86 and 0.85, respectively for Plot 1 and 2, with recall values of 0.7 and 0.67.

  1. Turning points in climate change adaptation

    NARCIS (Netherlands)

    Werners, Saskia Elisabeth; van Slobbe, Erik; Bölscher, Tobias; Oost, Albert; Pfenninger, Stefan; Trombi, Giacomo; Bindi, Marco; Moriondo, Marco

    2015-01-01

    Concerned decision makers increasingly pose questions as to whether current management practices are able to cope with climate change and increased climate variability. This signifies a shift in the framing of climate change from asking what its potential impacts are to asking whether it induces

  2. Turning points in climate change adaptation

    NARCIS (Netherlands)

    Werners, Saskia Elisabeth; Slobbe, van Erik; Bölscher, Tobias; Oost, Albert; Pfenninger, Stefan; Trombi, Giacomo; Bindi, Marco; Moriondo, Marco

    2015-01-01

    Concerned decision makers increasingly pose questions as to whether current management practices are able to cope with climate change and increased climate variability. This signifies a shift in the framing of climate change from asking what its potential impacts are to asking whether it induces

  3. Turning Point - Trajectory Analysis for Skiers

    OpenAIRE

    Waegli, A.; Skaloud, J.

    2007-01-01

    As with a growing number of athletes, competitive skiers are looking to GNSS technology to help evaluate and improve their performance. Positions logged during practice runs or races can be transformed into 3-D models of the exact trajectories skied to measure velocity, accelerations, and other performance variables. However, obstructions along a ski run, such as terrain and trees, can block satellite signals - suggesting a need to add low-cost inertial sensors to support continuous, accuract...

  4. At a long-awaited turning point

    Science.gov (United States)

    Ghosh, Arindam; Krishnan, Yamuna

    2014-07-01

    Research in nanotechnology in India is on an upswing given the substantial investments in the past two decades. Making an impact globally will now require investing in education, entrepreneurship, translational science, infrastructure for manufacturing, and changing the administrative mindset.

  5. Training Needs Identification: A Turning Point.

    Science.gov (United States)

    Thomas, Edwin A.

    1982-01-01

    Describes a systematic approach to training needs identification that is directly tied to changing organizational events and performance requirements. The discussion includes nine questions which address performance expectations. (JJD)

  6. [French immigration policy at a turning point?].

    Science.gov (United States)

    Wihtol De Wenden, C

    1995-01-01

    The author examines the changes to French immigration law adopted in 1993 in the light of current trends and pressures affecting migration to France. The focus is on the changes in the rules concerning the acquisition of French nationality, and the assimilation of existing immigrants from developing countries. The difficulties of resolving such problems at the national level while migration regulations are being developed at the European Community level are noted. Problems involving the control of the nation's borders, illegal immigration, and the growing demand for political asylum are also discussed. The author raises the possibility that immigration could be better managed in light of current labor market conditions in France.

  7. Clinical Facts, Turning Points and Complexity Theory

    Science.gov (United States)

    Lush, Margaret

    2011-01-01

    In this paper, I explore how we might link ideas about clinical facts to current issues in child psychotherapy research. I consider what our understanding of clinical facts might contribute to our research methods and how our research methods might better represent the clinical facts. The paper introduces a selection of psychoanalytic writers'…

  8. Canard solutions near a degenerate turning point

    Science.gov (United States)

    Forget, T.

    2006-12-01

    We are interested in the study of canard solutions in a singularly perturbed real first order ODE of the form epsilonu' = Ψ(x, u, a, epsilon), where epsilon > 0 is a small parameter, and a in Script R is a control parameter. An existence result for such solutions is given, and the method used in the demonstration allow us to conjecture the existence of a generalized epsilon1/(p+1)-asymptotic expansion for those solutions.

  9. Canard solutions near a degenerate turning point

    Energy Technology Data Exchange (ETDEWEB)

    Forget, T [Laboratoire de Mathematiques et Applications Pole, Sciences et Technologies - Universite de La Rochelle, Avenue Michel Crepeau, 17042 La Rochelle (France)

    2006-12-01

    We are interested in the study of canard solutions in a singularly perturbed real first order ODE of the form {epsilon}u' = {psi}(x, u, a, {epsilon}), where {epsilon} > 0 is a small parameter, and a element of R is a control parameter. An existence result for such solutions is given, and the method used in the demonstration allow us to conjecture the existence of a generalized {epsilon}{sup 1/(p+1)}-asymptotic expansion for those solutions.

  10. Nuclear energy at the turning point

    International Nuclear Information System (INIS)

    Weinberg, A.M.

    1977-07-01

    In deciding the future course of nuclear energy, it is necessary to re-examine man's long-term energy options, in particular solar energy and the breeder reactor. Both systems pose difficultiies: energy from the sun is likely to be expensive as well as limited, whereas a massive world-wide deployment of nuclear breeders will create problems of safety and of proliferation. Nuclear energy's long-term success depends on resolving both of these problems. Collocation of nuclear facilities with a system of resident inspectors are measures that ought to help increase the proliferation-resistance as well as the safety of a large-scale, long-term nuclear system based on breeders. In such a long-term system a strengthened International Atomic Energy Agency (IAEA) is viewed as playing a central role

  11. German Defense Policy At A Turning Point

    Science.gov (United States)

    2014-04-01

    could not bare more moral authority than “never again another Holocaust in Europe”.36 Lastly, Germany was driven by a desire to support the...War II, Germany has evolved a unique perspective on issues of national and regional security and the stability of the global order shaped largely by...Germany’s role in the major World Wars of the first half of the 20th century. Despite a culture that values “military restraint”2 Germany contributed

  12. A Direct Maximum Power Point Tracking Method for Single-Phase Grid Connected PV Inverters

    DEFF Research Database (Denmark)

    EL Aamri, Faicel; Maker, Hattab; Sera, Dezso

    2018-01-01

    in dynamic conditions, especially in low irradiance when the measurement of signals becomes more sensitive to noise. The proposed MPPT is designed for single-phase single-stage grid-connected PV inverters, and is based on estimating the instantaneous PV power and voltage ripples, using second...

  13. Single-Carrier Modulation for Neutral-Point-Clamped Inverters in Three-Phase Transformerless Photovoltaic Systems

    DEFF Research Database (Denmark)

    Guo, Xiaoqiang; Cavalcanti, Marcelo C.; Farias, Alexandre M.

    2013-01-01

    Modulation strategy is one of the most important issues for three-level neutral-point-clamped inverters in three-phase transformerless photovoltaic systems. A challenge for modulation is how to keep the common-mode voltages constant to reduce the leakage currents. A single-carrier modulation...

  14. Electrically continuous graphene from single crystal copper verified by terahertz conductance spectroscopy and micro four-point probe

    DEFF Research Database (Denmark)

    Buron, Jonas Christian Due; Pizzocchero, Filippo; Jessen, Bjarke Sørensen

    2014-01-01

    . Micro four-point probe resistance values measured on graphene grown on single crystalline copper in two different voltage-current configurations show close agreement with the expected distributions for a continuous 2D conductor, in contrast with previous observations on graphene grown on commercial...... noninvasive conductance characterization methods: ultrabroadband terahertz time-domain spectroscopy and micro four-point probe, which probe the electrical properties of the graphene film on different length scales, 100 nm and 10 μm, respectively. Ultrabroadband terahertz time-domain spectroscopy allows...... copper foil. The terahertz and micro four-point probe conductance values of the graphene grown on single crystalline copper shows a close to unity correlation, in contrast with those of the graphene grown on commercial copper foil, which we explain by the absence of extended defects on the microscale...

  15. A Starting Point for Fluorescence-Based Single-Molecule Measurements in Biomolecular Research

    Directory of Open Access Journals (Sweden)

    Alexander Gust

    2014-09-01

    Full Text Available Single-molecule fluorescence techniques are ideally suited to provide information about the structure-function-dynamics relationship of a biomolecule as static and dynamic heterogeneity can be easily detected. However, what type of single-molecule fluorescence technique is suited for which kind of biological question and what are the obstacles on the way to a successful single-molecule microscopy experiment? In this review, we provide practical insights into fluorescence-based single-molecule experiments aiming for scientists who wish to take their experiments to the single-molecule level. We especially focus on fluorescence resonance energy transfer (FRET experiments as these are a widely employed tool for the investigation of biomolecular mechanisms. We will guide the reader through the most critical steps that determine the success and quality of diffusion-based confocal and immobilization-based total internal reflection fluorescence microscopy. We discuss the specific chemical and photophysical requirements that make fluorescent dyes suitable for single-molecule fluorescence experiments. Most importantly, we review recently emerged photoprotection systems as well as passivation and immobilization strategies that enable the observation of fluorescently labeled molecules under biocompatible conditions. Moreover, we discuss how the optical single-molecule toolkit has been extended in recent years to capture the physiological complexity of a cell making it even more relevant for biological research.

  16. Analysis of single point and continuous wave of condensation root filling techniques by micro-computed tomography

    Directory of Open Access Journals (Sweden)

    Daniele Angerame

    2012-01-01

    Full Text Available The aim of the present microtomographic study was to investigate the quality of root canal filling and the voids formation in canals of extracted teeth instrumented with a simultaneous technique and filled with two different methods. Twenty-four single-rooted teeth were assigned to two experimental groups (no. = 12; canals were shaped with NiTi rotary files, irrigated with NaOCl and filled either with the single point (group 1 or the continuous wave of condensation technique (group 2. Specimens underwent microtomographic scanning. Collected data were statistically analyzed by nonparametric methods. Void mean percentages were found to be limited and similar between the two groups; the single point technique led to greater sealer thickness in partially oval canals.

  17. Single Point Incremental Forming to increase material knowledge and production flexibility

    Science.gov (United States)

    Habraken, A. M.

    2016-08-01

    Nowadays, manufactured pieces can be divided into two groups: mass production and production of low volume number of parts. Within the second group (prototyping or small batch production), an emerging solution relies on Incremental Sheet Forming or ISF. ISF refers to processes where the plastic deformation occurs by repeated contact with a relatively small tool. More specifically, many publications over the past decade investigate Single Point Incremental Forming (SPIF) where the final shape is determined only by the tool movement. This manufacturing process is characterized by the forming of sheets by means of a CNC controlled generic tool stylus, with the sheets clamped by means of a non-workpiece-specific clamping system and in absence of a partial or a full die. The advantage is no tooling requirements and often enhanced formability, however it poses a challenge in term of process control and accuracy assurance. Note that the most commonly used materials in incremental forming are aluminum and steel alloys however other alloys are also used especially for medical industry applications, such as cobalt and chromium alloys, stainless steel and titanium alloys. Some scientists have applied incremental forming on PVC plates and other on sandwich panels composed of propylene with mild steel and aluminum metallic foams with aluminum sheet metal. Micro incremental forming of thin foils has also been developed. Starting from the scattering of the results of Finite Element (FE) simulations, when one tries to predict the tool force (see SPIF benchmark of 2014 Numisheet conference), we will see how SPIF and even micro SPIF (process applied on thin metallic sheet with a few grains within the thickness) allow investigating the material behavior. This lecture will focus on the identification of constitutive laws, on the SPIF forming mechanisms and formability as well as the failure mechanism. Different hypotheses have been proposed to explain SPIF formability, they will be

  18. Single species biofilm-forming ability of root canal isolates on gutta-percha points.

    Science.gov (United States)

    Takemura, Naoki; Noiri, Yuichiro; Ehara, Atsushi; Kawahara, Takashi; Noguchi, Nobuo; Ebisu, Shigeyuki

    2004-12-01

    The participation of bacterial biofilms in the over-filled gutta-percha points associated with refractory periapical periodontitis has recently been reported. This study investigated the initial biofilm-forming ability of root canal isolates (Enterococcus faecalis, Streptococcus sanguis, Strep. intermedius, Strep. pyogenes, Staphylococcus aureus, Fusobacterium nucleatum, Propionibacterium acnes, Porphyromonas gingivalis and Prevotella intermedia) on gutta-percha points in vitro. Each bacterial strain was suspended in 100% cell culture medium or in culture medium containing 4.5, 45 or 90% (vol/vol) serum. The bacterial suspensions were then co-incubated anaerobically with gutta-percha points for 7 d. The gutta-percha points were processed for scanning electron microscopic observation and examined for biofilm presence and thickness. E. faecalis, Strep. sanguis, Strep. intermedius, Strep. pyogenes and Staph. aureus biofilms were generated on the surfaces of the specimens incubated in culture medium supplemented with 45 or 90% (vol/vol) serum. The E. faecalis and Strep. sanguis biofilms were significantly thicker than those of Strep. intermedius, Strep. pyogenes and Staph. aureus. No biofilms were detected on the specimens incubated with F. nucleatum, Prop. acnes, Porph. gingivalis and Prev. intermedia. These findings suggest that Gram-positive facultative anaerobes have the ability to colonize and form extracellular matrices on gutta-percha points, while serum plays a crucial role in biofilm formation. Copyright Eur J Oral Sci, 2004.

  19. X-Ray Radiography of Three-Point Bending of Single Human Trabecula

    Czech Academy of Sciences Publication Activity Database

    Jiroušek, Ondřej; Doktor, Tomáš; Kytýř, Daniel; Zlámal, Petr

    2012-01-01

    Roč. 45, S1 (2012), s. 261-261 ISSN 0021-9290 R&D Projects: GA ČR(CZ) GAP105/10/2305 Institutional support: RVO:68378297 Keywords : microspheres * strain measurement * three-point bending * trabecular bone * X-ray radiography Subject RIV: FI - Traumatology, Orthopedics Impact factor: 2.716, year: 2012

  20. Shape measurement system for single point incremental forming (SPIF) manufacts by using trinocular vision and random pattern

    International Nuclear Information System (INIS)

    Setti, Francesco; Bini, Ruggero; Lunardelli, Massimo; Bosetti, Paolo; Bruschi, Stefania; De Cecco, Mariolino

    2012-01-01

    Many contemporary works show the interest of the scientific community in measuring the shape of artefacts made by single point incremental forming. In this paper, we will present an algorithm able to detect feature points with a random pattern, check the compatibility of associations exploiting multi-stereo constraints and reject outliers and perform a 3D reconstruction by dense random patterns. The algorithm is suitable for a real-time application, in fact it needs just three images and a synchronous relatively fast processing. The proposed method has been tested on a simple geometry and results have been compared with a coordinate measurement machine acquisition. (paper)

  1. A High-Power-Density Single-Phase Rectifier Based on Three-Level Neutral-Point Clamped Circuits

    Directory of Open Access Journals (Sweden)

    Tao Zhou

    2017-05-01

    Full Text Available A single-phase three-level converter is suitable for medium-power applications, with an interface voltage that is higher than that of a traditional two-level configuration. The three-level neutral-point clamped converter is adopted using four switches in each bridge arm, which, compared to a two-level rectifier, leads to less voltage stress, a lower switching frequency, and switching loss on switches. The transient current control strategy is designed to control the active power. The single-phase space vector pulse width modulation (SVPWM with a voltage balance strategy is designed to solve the neutral point voltage fluctuation problem and keep the dc-link voltage stable. A 1.3 kW high-power-density prototype based on SiC MOSFET was built and tested. The experimental results verified the high performance of steady-state and dynamic responses.

  2. Highly macroscopically degenerated single-point ground states as source of specific heat capacity anomalies in magnetic frustrated systems

    Science.gov (United States)

    Jurčišinová, E.; Jurčišin, M.

    2018-04-01

    Anomalies of the specific heat capacity are investigated in the framework of the exactly solvable antiferromagnetic spin- 1 / 2 Ising model in the external magnetic field on the geometrically frustrated tetrahedron recursive lattice. It is shown that the Schottky-type anomaly in the behavior of the specific heat capacity is related to the existence of unique highly macroscopically degenerated single-point ground states which are formed on the borders between neighboring plateau-like ground states. It is also shown that the very existence of these single-point ground states with large residual entropies predicts the appearance of another anomaly in the behavior of the specific heat capacity for low temperatures, namely, the field-induced double-peak structure, which exists, and should be observed experimentally, along with the Schottky-type anomaly in various frustrated magnetic system.

  3. Characteristics of X-point lobe structures in single-null discharges on MAST

    Czech Academy of Sciences Publication Activity Database

    Harrison, J.R.; Kirk, A.; Chapman, I.T.; Cahyna, Pavel; Liu, Y.; Nardon, E.; Thornton, A.J.

    2014-01-01

    Roč. 54, č. 6 (2014), 064015-064015 ISSN 0029-5515 R&D Projects: GA ČR GAP205/11/2341 Institutional support: RVO:61389021 Keywords : tokamak * MAST * X-point * resonant magnetic perturbation Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 3.062, year: 2014 http://iopscience.iop.org/0029-5515/54/6/064015/pdf/0029-5515_54_6_064015.pdf

  4. Characterization of Point Defects in Lithium Aluminate (LiAlO2) Single Crystals

    Science.gov (United States)

    2015-09-17

    insulating wide-band gap material currently under development for tritium breeding and radiation detection and dosimetry appli- cations. Point defects...110 xi List of Tables Table Page 1.1. Anion - Cation Bond Lengths...the valence band from the bottom of the conduction band is known as the band gap energy, and is normally represented by Eg. If a photon with an energy

  5. A QRS Detection and R Point Recognition Method for Wearable Single-Lead ECG Devices.

    Science.gov (United States)

    Chen, Chieh-Li; Chuang, Chun-Te

    2017-08-26

    In the new-generation wearable Electrocardiogram (ECG) system, signal processing with low power consumption is required to transmit data when detecting dangerous rhythms and to record signals when detecting abnormal rhythms. The QRS complex is a combination of three of the graphic deflection seen on a typical ECG. This study proposes a real-time QRS detection and R point recognition method with low computational complexity while maintaining a high accuracy. The enhancement of QRS segments and restraining of P and T waves are carried out by the proposed ECG signal transformation, which also leads to the elimination of baseline wandering. In this study, the QRS fiducial point is determined based on the detected crests and troughs of the transformed signal. Subsequently, the R point can be recognized based on four QRS waveform templates and preliminary heart rhythm classification can be also achieved at the same time. The performance of the proposed approach is demonstrated using the benchmark of the MIT-BIH Arrhythmia Database, where the QRS detected sensitivity (Se) and positive prediction (+P) are 99.82% and 99.81%, respectively. The result reveals the approach's advantage of low computational complexity, as well as the feasibility of the real-time application on a mobile phone and an embedded system.

  6. Optimal fits of diffusion constants from single-time data points of Brownian trajectories.

    Science.gov (United States)

    Boyer, Denis; Dean, David S; Mejía-Monasterio, Carlos; Oshanin, Gleb

    2012-12-01

    Experimental methods based on single particle tracking (SPT) are being increasingly employed in the physical and biological sciences, where nanoscale objects are visualized with high temporal and spatial resolution. SPT can probe interactions between a particle and its environment but the price to be paid is the absence of ensemble averaging and a consequent lack of statistics. Here we address the benchmark question of how to accurately extract the diffusion constant of one single Brownian trajectory. We analyze a class of estimators based on weighted functionals of the square displacement. For a certain choice of the weight function these functionals provide the true ensemble averaged diffusion coefficient, with a precision that increases with the trajectory resolution.

  7. Point defects and electric compensation in gallium arsenide single crystals; Punktdefekte und elektrische Kompensation in Galliumarsenid-Einkristallen

    Energy Technology Data Exchange (ETDEWEB)

    Kretzer, Ulrich

    2007-12-10

    In the present thesis the point-defect budget of gallium arsenide single crystals with different dopings is studied. It is shown, in which way the concentration of the single point defects depende on the concentration of the dopants, the stoichiometry deviation, and the position of the Fermi level. For this serve the results of the measurement-technical characterization of a large number of samples, in the fabrication of which these parameters were directedly varied. The main topic of this thesis lies in the development of models, which allow a quantitative description of the experimentally studied electrical and optical properties of gallium arsenide single crystals starting from the point-defect concentrations. Because from point defects charge carriers can be set free, their concentration determines essentially the charge-carrier concentration in the bands. In the ionized state point defects act as scattering centers for free charge carriers and influence by this the drift mobility of the charge carriers. A thermodynamic modeling of the point-defect formation yields statements on the equilibrium concentrations of the point defects in dependence on dopant concentration and stoichiometry deviation. It is show that the electrical properties of the crystals observed at room temperature result from the kinetic suppression of processes, via which the adjustment of a thermodynamic equilibrium between the point defects is mediated. [German] In der vorliegenden Arbeit wird der Punktdefekthaushalt von Galliumarsenid-Einkristallen mit unterschiedlichen Dotierungen untersucht. Es wird gezeigt, in welcher Weise die Konzentration der einzelnen Punktdefekte von der Konzentration der Dotierstoffe, der Stoechiometrieabweichung und der Lage des Ferminiveaus abhaengen. Dazu dienen die Ergebnisse der messtechnischen Charakterisierung einer grossen Anzahl von Proben, bei deren Herstellung diese Parameter gezielt variiert wurden. Der Schwerpunkt der Arbeit liegt in der Entwicklung

  8. Single-point reactive power control method on voltage rise mitigation in residential networks with high PV penetration

    DEFF Research Database (Denmark)

    Hasheminamin, Maryam; Agelidis, Vassilios; Ahmadi, Abdollah

    2018-01-01

    Voltage rise (VR) due to reverse power flow is an important obstacle for high integration of Photovoltaic (PV) into residential networks. This paper introduces and elaborates a novel methodology of an index-based single-point-reactive power-control (SPRPC) methodology to mitigate voltage rise by ...... system with high r/x ratio. Efficacy, effectiveness and cost study of SPRPC is compared to droop control to evaluate its advantages....... by absorbing adequate reactive power from one selected point. The proposed index utilizes short circuit analysis to select the best point to apply this Volt/Var control method. SPRPC is supported technically and financially by distribution network operator that makes it cost effective, simple and efficient...

  9. New, multi-dimensional reconstructions for the 12-detector, scanned focal point, single-photon tomograph

    International Nuclear Information System (INIS)

    Stoddart, H.A.; Stoddart, H.F.

    1990-01-01

    The heuristic reconstruction process used for the highly-focused, scanned focal-point tomograph described by us in 1979 has remained unchanged until recently. This paper describes an entirely new and completely rigorous reconstruction for this unique geometry which produces dramatically improved images that are least square estimates of the objects. The handling of attenuation, scattering, and object power spectra are discussed. Reconstructions are described for 2D, 3D from three slices, time varying 3D from three slices, and 3D from a large set of slices. Reconstructions for simulated and actual clinical data are shown and the accuracy for quantitation is estimated

  10. [Turning points in world history: urological comments on pathography of famous people: did Napoleon Bonaparte have a cystitis during the battle of Waterloo and was the battle lost because of that?].

    Science.gov (United States)

    Hatzinger, M; Stastny, M; Haferkamp, A

    2011-03-01

    Apparently unimportant diseases of some prominent figures can have a considerable effect on the course of time at turning points in world history. It is quite conceivable that the Battle of Waterloo on 18 June 1815 had been lost by France because Napoleon was not in full possession of his powers, because he was suffering from acute cystitis. Adverse weather conditions with continuous rain and coldness in advance of the battle, extremely primitive hygienic conditions and more than simple quarters for the night led to the development of cystitis. Based on the records of his biographers, his personal physician and the letters to his brother, we know that Napoleon was not able to give the command to attack in the early morning as intended, but in the early noon, only because of his bad general condition. This delay of several hours led, as we all know, to the intervention of Prussia and the devastating defeat of France. Thus it appears that a relatively unimportant urological disease influenced the course of world history crucially.

  11. 1996, a turning point in the evolution of the EDF with good financial results; 1996, une annee charniere dans l'evolution d'EDF avec de bons resultants financiers

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    This conference held on March 1997 presents the financial results obtained in 1996 by French Electricity Company EDF (Electricite de France). This year represented a turning point because essential landmarks were established in 1996. An european directive has been adopted in 1996 defining the framework in which european electricity market will function as well as the rules for its opening to competition. Discussions with the trade unions were conducted at the beginning of 1997and a social agreement aiming at the amelioration of services and hiring of 11,000 to 15,000 young people in the next three years. Finally, a new contract of enterprise with the state has been discussed and approved in March 5, 1997, which redefined the place and the role of EDF in the French economy, in the new stage of electricity market started by the opening to competition. The document contains the following 8 chapters: 1. Financial results and enterprise management; 2. Institutional frame and the relation with the state; 3. Development in France; 4. International development; 5. Alliances, partnerships and cooperation; 6. Management, social and human resources; 7. Environment; 8. Technical results.

  12. CScape: a tool for predicting oncogenic single-point mutations in the cancer genome.

    Science.gov (United States)

    Rogers, Mark F; Shihab, Hashem A; Gaunt, Tom R; Campbell, Colin

    2017-09-14

    For somatic point mutations in coding and non-coding regions of the genome, we propose CScape, an integrative classifier for predicting the likelihood that mutations are cancer drivers. Tested on somatic mutations, CScape tends to outperform alternative methods, reaching 91% balanced accuracy in coding regions and 70% in non-coding regions, while even higher accuracy may be achieved using thresholds to isolate high-confidence predictions. Positive predictions tend to cluster in genomic regions, so we apply a statistical approach to isolate coding and non-coding regions of the cancer genome that appear enriched for high-confidence predicted disease-drivers. Predictions and software are available at http://CScape.biocompute.org.uk/ .

  13. Potential use of point shear wave elastography for the pancreas: A single center prospective study

    Energy Technology Data Exchange (ETDEWEB)

    Kawada, Natsuko, E-mail: kawada-na@mc.pref.osaka.jp [Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari, Osaka 537-8511 (Japan); Department of Gastroenterology, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293 (Japan); Tanaka, Sachiko, E-mail: sachi686@cocoa.plala.or.jp [Osaka Center for Cancer and Cardiovascular Disease Prevention, 1-6-107, Morinomiya, Johtoh, Osaka 536-8588 (Japan); Uehara, Hiroyuki, E-mail: uehara-hi@mc.pref.osaka.jp [Department of Gastroenterology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari, Osaka 537-8511 (Japan); Ohkawa, Kazuyoshi, E-mail: okawa-ka@mc.pref.osaka.jp [Department of Gastroenterology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari, Osaka 537-8511 (Japan); Yamai, Takuo, E-mail: yamai-ta@mc.pref.osaka.jp [Department of Gastroenterology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari, Osaka 537-8511 (Japan); Takada, Ryoji, E-mail: takada-ry@mc.pref.osaka.jp [Department of Gastroenterology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari, Osaka 537-8511 (Japan); Shiroeda, Hisakazu, E-mail: shiroeda@kanazawa-med.ac.jp [Department of Gastroenterology, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293 (Japan); Arisawa, Tomiyasu, E-mail: tarisawa@kanazawa-med.ac.jp [Department of Gastroenterology, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293 (Japan); Tomita, Yasuhiko, E-mail: tomota-ya@mc.pref.osaka.jp [Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari, Osaka 537-8511 (Japan)

    2014-04-15

    Aim: Clinical use of point shear wave elastography for the liver has been established, however, few studies demonstrated its usefulness for the pancreas. A prospective study was conducted to clarify its feasibility for the pancreas and its usefulness for the identification of high risk group for pancreatic cancer. Patients and methods: Consecutive eighty-five patients underwent point shear wave elastography for the pancreas. The success rate of shear wave velocity (SWV) measurement, that is the number of successful measurements over total 10 measurements, was recorded. The SWV of the pancreas measured at non-tumorous area was compared between patients with and without pancreatic cancer. Factors associated with high SWV were determined by logistic regression model. Results: Sixty patients were included, of these 18 had pancreatic cancer. The success rate of 100% was achieved at the head, the body and the tail of the pancreas in 80%, 83%, and 68% of the patients, respectively. The success rate of ≥80% was achieved in 100%, 100%, and 96% of the patients, respectively. Although mean SWV of the pancreas harboring pancreatic cancer tended to be higher compared with that of the pancreas without cancer (1.51 ± 0.45 m/s vs 1.43 ± 0.28 m/s), they did not reach statistical significance. Multivariate analysis showed that increased amount of alcohol intake was associated with high SWV. Conclusion: The SWV of the pancreas was measured with excellent success rate. However, tendency of higher SWV obtained from the pancreas harboring pancreatic cancer needed to be further investigated.

  14. Design of thermostable rhamnogalacturonan lyase mutants from Bacillus licheniformis by combination of targeted single point mutations

    DEFF Research Database (Denmark)

    da Silva, Ines Isabel Cardoso Rodrigues; Jers, Carsten; Otten, Harm

    2014-01-01

    Rhamnogalacturonan I lyases (RGI lyases) (EC 4.2.2.-) catalyze cleavage of α-1,4 bonds between rhamnose and galacturonic acid in the backbone of pectins by β-elimination. In the present study, targeted improvement of the thermostability of a PL family 11 RGI lyase from Bacillus licheniformis (DSM...... the wild-type RGI lyase in Bacillus subtilis as opposed to in Pichia pastoris; this effect is suggested to be a negative result of glycosylation of the P. pastoris expressed enzyme. A ~ twofold improvement in thermal stability at 60 °C, accompanied by less significant increases in Tm of the enzyme mutants......, were obtained due to additive stabilizing effects of single amino acid mutations (E434L, G55V, and G326E) compared to the wild type. The crystal structure of the B. licheniformis wild-type RGI lyase was also determined; the structural analysis corroborated that especially mutation of charged amino...

  15. A study of point defect aggregates in #betta#-irradiated LiF single crystals

    International Nuclear Information System (INIS)

    Frugoli, P.A.; Pimentel, C.A.F.

    1982-11-01

    Diffuse X-ray scattering near the Bragg Reflection and Bragg profile analaysis have been made in #betta#-irradiated LiF single crystal X-ray diffractometer. An estimate of the half-width of the diffraction patterns was done and preferential alteration in the profile parameters was observed. Clusters with mean parameter sizes from hundreds to thousands of angstroms were observed but each sample has presented a set of average size values. The nature of clusters was found to be dependent on the #betta#-dose: vacancy at low dose (approximately 10 MRad) and interstitial at high dose (approximately 50 MRad). Some process of coalescence at 50 MRad seems to occur. (Author) [pt

  16. High-performance analysis of single interphase cells with custom DNA probes spanning translocation break points

    Science.gov (United States)

    Weier, Heinz-Ulli G.; Munne, S.; Lersch, Robert A.; Marquez, C.; Wu, J.; Pedersen, Roger A.; Fung, Jingly

    1999-06-01

    The chromatin organization of interphase cell nuclei, albeit an object of intense investigation, is only poorly understood. In the past, this has hampered the cytogenetic analysis of tissues derived from specimens where only few cells were actively proliferating or a significant number of metaphase cells could be obtained by induction of growth. Typical examples of such hard to analyze cell systems are solid tumors, germ cells and, to a certain extent, fetal cells such as amniocytes, blastomeres or cytotrophoblasts. Balanced reciprocal translocations that do not disrupt essential genes and thus do not led to disease symptoms exit in less than one percent of the general population. Since the presence of translocations interferes with homologue pairing in meiosis, many of these individuals experience problems in their reproduction, such as reduced fertility, infertility or a history of spontaneous abortions. The majority of translocation carriers enrolled in our in vitro fertilization (IVF) programs carry simple translocations involving only two autosomes. While most translocations are relatively easy to spot in metaphase cells, the majority of cells biopsied from embryos produced by IVF are in interphase and thus unsuitable for analysis by chromosome banding or FISH-painting. We therefore set out to analyze single interphase cells for presence or absence of specific translocations. Our assay, based on fluorescence in situ hybridization (FISH) of breakpoint-spanning DNA probes, detects translocations in interphase by visual microscopic inspection of hybridization domains. Probes are prepared so that they span a breakpoint and cover several hundred kb of DNA adjacent to the breakpoint. On normal chromosomes, such probes label a contiguous stretch of DNA and produce a single hybridization domain per chromosome in interphase cells. The translocation disrupts the hybridization domain and the resulting two fragments appear as physically separated hybridization domains in

  17. A Single Phase Doubly Grounded Semi-Z-Source Inverter for Photovoltaic (PV Systems with Maximum Power Point Tracking (MPPT

    Directory of Open Access Journals (Sweden)

    Tofael Ahmed

    2014-06-01

    Full Text Available In this paper, a single phase doubly grounded semi-Z-source inverter with maximum power point tracking (MPPT is proposed for photovoltaic (PV systems. This proposed system utilizes a single-ended primary inductor (SEPIC converter as DC-DC converter to implement the MPPT algorithm for tracking the maximum power from a PV array and a single phase semi-Z-source inverter for integrating the PV with AC power utilities. The MPPT controller utilizes a fast-converging algorithm to track the maximum power point (MPP and the semi-Z-source inverter utilizes a nonlinear SPWM to produce sinusoidal voltage at the output. The proposed system is able to track the MPP of PV arrays and produce an AC voltage at its output by utilizing only three switches. Experimental results show that the fast-converging MPPT algorithm has fast tracking response with appreciable MPP efficiency. In addition, the inverter shows the minimization of common mode leakage current with its ground sharing feature and reduction of the THD as well as DC current components at the output during DC-AC conversion.

  18. Fast computation of quadrupole and hexadecapole approximations in microlensing with a single point-source evaluation

    Science.gov (United States)

    Cassan, Arnaud

    2017-07-01

    The exoplanet detection rate from gravitational microlensing has grown significantly in recent years thanks to a great enhancement of resources and improved observational strategy. Current observatories include ground-based wide-field and/or robotic world-wide networks of telescopes, as well as space-based observatories such as satellites Spitzer or Kepler/K2. This results in a large quantity of data to be processed and analysed, which is a challenge for modelling codes because of the complexity of the parameter space to be explored and the intensive computations required to evaluate the models. In this work, I present a method that allows to compute the quadrupole and hexadecapole approximations of the finite-source magnification with more efficiency than previously available codes, with routines about six times and four times faster, respectively. The quadrupole takes just about twice the time of a point-source evaluation, which advocates for generalizing its use to large portions of the light curves. The corresponding routines are available as open-source python codes.

  19. On the estimation of the current density in space plasmas: Multi- versus single-point techniques

    Science.gov (United States)

    Perri, Silvia; Valentini, Francesco; Sorriso-Valvo, Luca; Reda, Antonio; Malara, Francesco

    2017-06-01

    Thanks to multi-spacecraft mission, it has recently been possible to directly estimate the current density in space plasmas, by using magnetic field time series from four satellites flying in a quasi perfect tetrahedron configuration. The technique developed, commonly called ;curlometer; permits a good estimation of the current density when the magnetic field time series vary linearly in space. This approximation is generally valid for small spacecraft separation. The recent space missions Cluster and Magnetospheric Multiscale (MMS) have provided high resolution measurements with inter-spacecraft separation up to 100 km and 10 km, respectively. The former scale corresponds to the proton gyroradius/ion skin depth in ;typical; solar wind conditions, while the latter to sub-proton scale. However, some works have highlighted an underestimation of the current density via the curlometer technique with respect to the current computed directly from the velocity distribution functions, measured at sub-proton scales resolution with MMS. In this paper we explore the limit of the curlometer technique studying synthetic data sets associated to a cluster of four artificial satellites allowed to fly in a static turbulent field, spanning a wide range of relative separation. This study tries to address the relative importance of measuring plasma moments at very high resolution from a single spacecraft with respect to the multi-spacecraft missions in the current density evaluation.

  20. Ambiguity resolution in precise point positioning with hourly data for global single receiver

    Science.gov (United States)

    Zhang, Xiaohong; Li, Pan; Guo, Fei

    2013-01-01

    Integer ambiguity resolution (IAR) can improve precise point positioning (PPP) performance significantly. IAR for PPP became a highlight topic in global positioning system (GPS) community in recent years. More and more researchers focus on this issue. Progress has been made in the latest years. In this paper, we aim at investigating and demonstrating the performance of a global zero-differenced (ZD) PPP IAR service for GPS users by providing routine ZD uncalibrated fractional offsets (UFOs) for wide-lane and narrow-lane. Data sets from all IGS stations collected on DOY 1, 100, 200 and 300 of 2010 are used to validate and demonstrate this global service. Static experiment results show that an accuracy better than 1 cm in horizontal and 1-2 cm in vertical could be achieved in ambiguity-fixed PPP solution with only hourly data. Compared with PPP float solution, an average improvement reaches 58.2% in east, 28.3% in north and 23.8% in vertical for all tested stations. Results of kinematic experiments show that the RMS of kinematic PPP solutions can be improved from 21.6, 16.6 and 37.7 mm to 12.2, 13.3 and 34.3 mm for the fixed solutions in the east, north and vertical components, respectively. Both static and kinematic experiments show that wide-lane and narrow-lane UFO products of all satellites can be generated and provided in a routine way accompanying satellite orbit and clock products for the PPP user anywhere around the world, to obtain accurate and reliable ambiguity-fixed PPP solutions.

  1. Channel capacity of TDD-OFDM-MIMO for multiple access points in a wireless single-frequency-network

    DEFF Research Database (Denmark)

    Takatori, Y.; Fitzek, Frank; Tsunekawa, K.

    2005-01-01

    MIMO data transmission scheme, which combines Single-Frequency-Network (SFN) with TDD-OFDM-MIMO applied for wireless LAN networks. In our proposal, we advocate to use SFN for multiple access points (MAP) MIMO data transmission. The goal of this approach is to achieve very high channel capacity in both...... LOS and non line of sight (NLOS) environments. The channel capacity of the proposed method is derived for the direct path environments and it confirms the effectiveness of the proposed scheme in the LOS scenario. Moreover, solid computer simulation results confirm the effectiveness of the proposed...

  2. Theoretical Basis for Stochastic Optimization Starting from a Single Point in the Search Space Formed by Real DNA Molecules

    Science.gov (United States)

    Someya, Hiroshi; Yamamura, Masayuki; Sakamoto, Kensaku

    This paper discusses DNA-based stochastic optimizations under the constraint that the search starts from a given point in a search space. Generally speaking, a stochastic optimization method explores a search space and finds out the optimum or a sub-optimum after many cycles of trials and errors. This search process could be implemented efficiently by ``molecular computing'', which processes DNA molecules by the techniques of molecular biology to generate and evaluate a vast number of solution candidates at a time. We assume the exploration starting from a single point, and propose a method to embody DNA-based optimization under this constraint, because this method has a promising application in the research field of protein engineering. In this application, a string of nucleotide bases (a base sequence) encodes a protein possessing a specific activity, which could be given as a value of an objective function. Thus, a problem of obtaining a protein with the optimum or a sub-optimum about the desired activity corresponds to a combinatorial problem of obtaining a base sequence giving the optimum or a sub-optimum in the sequence space. Biologists usually modify a base sequence corresponding to a naturally occurring protein into another sequence giving a desired activity. In other words, they explore the space in the proximity of a natural protein as a start point. We first examined if the optimization methods that involve a single start point, such as simulated annealing, Gibbs sampler, and MH algorithms, can be implemented by DNA-based operations. Then, we proposed an application of genetic algorithm, and examined the performance of this application on a model fitness landscape by computer experiments. These experiments gave helpful guidelines in the embodiments of DNA-based stochastic optimization, including a better design of crossover operator.

  3. Detecting shifts in gene regulatory networks during time-course experiments at single-time-point temporal resolution.

    Science.gov (United States)

    Takenaka, Yoichi; Seno, Shigeto; Matsuda, Hideo

    2015-10-01

    Comprehensively understanding the dynamics of biological systems is one of the greatest challenges in biology. Vastly improved biological technologies have provided vast amounts of information that must be understood by bioinformatics and systems biology researchers. Gene regulations have been frequently modeled by ordinary differential equations or graphical models based on time-course gene expression profiles. The state-of-the-art computational approaches for analyzing gene regulations assume that their models are same throughout time-course experiments. However, these approaches cannot easily analyze transient changes at a time point, such as diauxic shift. We propose a score that analyzes the gene regulations at each time point. The score is based on the information gains of information criterion values. The method detects the shifts in gene regulatory networks (GRNs) during time-course experiments with single-time-point resolution. The effectiveness of the method is evaluated on the diauxic shift from glucose to lactose in Escherichia coli. Gene regulation shifts were detected at two time points: the first corresponding to the time at which the growth of E. coli ceased and the second corresponding to the end of the experiment, when the nutrient sources (glucose and lactose) had become exhausted. According to these results, the proposed score and method can appropriately detect the time of gene regulation shifts. The method based on the proposed score provides a new tool for analyzing dynamic biological systems. Because the score value indicates the strength of gene regulation at each time point in a gene expression profile, it can potentially infer hidden GRNs from time-course experiments.

  4. Enhancement of the point defect pinning effect in Mo-doped Bi2212 single crystals of reduced anisotropy

    CERN Document Server

    Han, S H; Dai, Y; Zhang, Y; Zhang, H; Zhao, Y

    2002-01-01

    High quality Bi sub 2 Sr sub 2 CaCu sub 2 sub - sub x Mo sub x O sub y (x = 0, 0.01 and 0.02) single crystals have been grown by a self-flux method in a horizontal temperature gradient and their flux pinning and irreversibility behaviour have been investigated. The irreversibility lines of the undoped and Mo-doped Bi2212 crystals have been greatly improved by reducing the anisotropy parameter gamma. However, this improvement is much more pronounced for Mo-doped crystals than for the undoped ones. The peak effect of magnetization loops also changes with both Mo-doping and gamma. The results provide strong evidence that the point defect pinning served by Mo is greatly enhanced when the anisotropy of the system is reduced.

  5. Revisiting single-point incremental forming and formability/failure diagrams by means of finite elements and experimentation

    DEFF Research Database (Denmark)

    Silva, M. B.; Skjødt, Martin; Bay, Niels

    2009-01-01

    the forming limits determined by the analytical framework with experimental values. It is shown that agreement between analytical, finite element, and experimental results is good, implying that the previously proposed analytical framework can be utilized to explain the mechanics of deformation......In a previously published work, the current authors presented an analytical framework, built upon the combined utilization of membrane analysis and ductile damage mechanics, that is capable of modelling the fundamentals of single-point incremental forming (SPIF) of metallic sheets. The analytical...... mode of deformation. The study of the morphology of the cracks combined with the experimentally observed suppression of neck formation enabled the authors to conclude that traditional forming limit curves are inapplicable for describing failure. Instead, fracture forming limit curves should be employed...

  6. High performance control strategy for single-phase three-level neutral-point-clamped traction four-quadrant converters

    DEFF Research Database (Denmark)

    Kejian, Song; Konstantinou, Georgios; Jing, Li

    2017-01-01

    multiple unit traction system is proposed in this study. The strategy is based on a multiple frequency tuned quasi-proportional resonant controller in the ac-side current loop and a multiple frequency tuned notch filter in the dc-link voltage loop. Under the typical supply voltage distortion present......Operational data from Chinese railways indicate a number of challenges for traction four-quadrant converter (4QC) control including low-order voltage and current harmonics and reference tracking. A control strategy for a single-phase three-level neutral-point-clamped 4QC employed in the electric...... in the network, the proposed control strategy improves the current tracking performance and reduces the line current harmonics, when compared with conventional control strategies. Experimental results, both under purely sinusoidal and distorted supply voltages, validate the effectiveness of the proposed control...

  7. Experimental and numerical study on optimization of the single point incremental forming of AINSI 304L stainless steel sheet

    Science.gov (United States)

    Saidi, B.; Giraud-Moreau, L.; Cherouat, A.; Nasri, R.

    2017-09-01

    AINSI 304L stainless steel sheets are commonly formed into a variety of shapes for applications in the industrial, architectural, transportation and automobile fields, it’s also used for manufacturing of denture base. In the field of dentistry, there is a need for personalized devises that are custom made for the patient. The single point incremental forming process is highly promising in this area for manufacturing of denture base. The single point incremental forming process (ISF) is an emerging process based on the use of a spherical tool, which is moved along CNC controlled tool path. One of the major advantages of this process is the ability to program several punch trajectories on the same machine in order to obtain different shapes. Several applications of this process exist in the medical field for the manufacturing of personalized titanium prosthesis (cranial plate, knee prosthesis...) due to the need of product customization to each patient. The objective of this paper is to study the incremental forming of AISI 304L stainless steel sheets for future applications in the dentistry field. During the incremental forming process, considerable forces can occur. The control of the forming force is particularly important to ensure the safe use of the CNC milling machine and preserve the tooling and machinery. In this paper, the effect of four different process parameters on the maximum force is studied. The proposed approach consists in using an experimental design based on experimental results. An analysis of variance was conducted with ANOVA to find the input parameters allowing to minimize the maximum forming force. A numerical simulation of the incremental forming process is performed with the optimal input process parameters. Numerical results are compared with the experimental ones.

  8. Investigating the use of multi-point coupling for single-sensor bearing estimation in one direction

    Science.gov (United States)

    Woolard, Americo G.; Phoenix, Austin A.; Tarazaga, Pablo A.

    2018-04-01

    Bearing estimation of radially propagating symmetric waves in solid structures typically requires a minimum of two sensors. As a test specimen, this research investigates the use of multi-point coupling to provide directional inference using a single-sensor. By this provision, the number of sensors required for localization can be reduced. A finite-element model of a beam is constructed with a symmetrically placed bipod that has asymmetric joint-stiffness properties. Impulse loading is applied at different points along the beam, and measurements are taken from the apex of the bipod. A technique is developed to determine the direction-of-arrival of the propagating wave. The accuracy when using the bipod with the developed technique is compared against results gathered without the bipod and measuring from an asymmetric location along the beam. The results show 92% accuracy when the bipod is used, compared to 75% when measuring without the bipod from an asymmetric location. A geometry investigation finds the best accuracy results when one leg of the bipod has a low stiffness and a large diameter relative to the other leg.

  9. Single-Point Incremental Forming of Two Biocompatible Polymers: An Insight into Their Thermal and Structural Properties

    Directory of Open Access Journals (Sweden)

    Luis Marcelo Lozano-Sánchez

    2018-04-01

    Full Text Available Sheets of polycaprolactone (PCL and ultra-high molecular weight polyethylene (UHMWPE were fabricated and shaped by the Single-Point Incremental Forming process (SPIF. The performance of these biocompatible polymers in SPIF was assessed through the variation of four main parameters: the diameter of the forming tool, the spindle speed, the feed rate, and the step size based on a Box–Behnken design of experiments of four variables and three levels. The design of experiments allowed us to identify the parameters that most affect the forming of PCL and UHMWPE. The study was completed by means of a deep characterization of the thermal and structural properties of both polymers. These properties were correlated to the performance of the polymers observed in SPIF, and it was found that the polymer chains are oriented as a consequence of the SPIF processing. Moreover, by X-ray diffraction it was proved that polymer chains behave differently on each surface of the fabricated parts, since the chains on the surface in contact with the forming tool are oriented horizontally, while on the opposite surface they are oriented in the vertical direction. The unit cell of UHMWPE is distorted, passing from an orthorhombic cell to a monoclinic due to the slippage between crystallites. This slippage between crystallites was observed in both PCL and UHMWPE, and was identified as an alpha star thermal transition located in the rubbery region between the glass transition and the melting point of each polymer.

  10. Mitigation of Critical Single Point Failure (SPF) Material - Laminac 4116 Binder Replacement Program for Parachute and Cluster Stars Illuminant Compositions for Hand Held Signals

    National Research Council Canada - National Science Library

    Lakshminarayanan, G. R; Chen, Gary; Ames, Richard; Lee, Wai T; Wejsa, James L

    2006-01-01

    Laminac 4116 binder has been identified as a single point failure (SPF) material since it is being produced by only one company and there is a possibility that the company may discontinue production due to low product demand...

  11. The Local Turn

    NARCIS (Netherlands)

    Warren, Carol; Visser, Leontine

    2016-01-01

    The local turn in good governance theory and practice responded to critiques of the ineffectiveness of state management and the inequity of privatization alternatives in natural resource management. Confounding expectations of greater effectiveness from decentralised governance, including

  12. Evaluation of mixing downstream of tees in duct systems with respect to single point representative air sampling.

    Science.gov (United States)

    Kim, Taehong; O'Neal, Dennis L; Ortiz, Carlos

    2006-09-01

    Air duct systems in nuclear facilities must be monitored with continuous sampling in case of an accidental release of airborne radionuclides. The purpose of this work is to identify the air sampling locations where the velocity and contaminant concentrations fall below the 20% coefficient of variation required by the American National Standards Institute/Health Physics Society N13.1-1999. Experiments of velocity and tracer gas concentration were conducted on a generic "T" mixing system which included combinations of three sub ducts, one main duct, and air velocities from 0.5 to 2 m s (100 to 400 fpm). The experimental results suggest that turbulent mixing provides the accepted velocity coefficients of variation after 6 hydraulic diameters downstream of the T-junction. About 95% of the cases achieved coefficients of variation below 10% by 6 hydraulic diameters. However, above a velocity ratio (velocity in the sub duct/velocity in the main duct) of 2, velocity profiles were uniform in a shorter distance downstream of the T-junction as the velocity ratio went up. For the tracer gas concentration, the distance needed for the coefficients of variation to drop 20% decreased with increasing velocity ratio due to the sub duct airflow momentum. The results may apply to other duct systems with similar geometries and, ultimately, be a basis for selecting a proper sampling location under the requirements of single point representative sampling.

  13. Role of single-point mutations and deletions on transition temperatures in ideal proteinogenic heteropolymer chains in the gas phase.

    Science.gov (United States)

    Olivares-Quiroz, L

    2016-07-01

    A coarse-grained statistical mechanics-based model for ideal heteropolymer proteinogenic chains of non-interacting residues is presented in terms of the size K of the chain and the set of helical propensities [Formula: see text] associated with each residue j along the chain. For this model, we provide an algorithm to compute the degeneracy tensor [Formula: see text] associated with energy level [Formula: see text] where [Formula: see text] is the number of residues with a native contact in a given conformation. From these results, we calculate the equilibrium partition function [Formula: see text] and characteristic temperature [Formula: see text] at which a transition from a low to a high entropy states is observed. The formalism is applied to analyze the effect on characteristic temperatures [Formula: see text] of single-point mutations and deletions of specific amino acids [Formula: see text] along the chain. Two probe systems are considered. First, we address the case of a random heteropolymer of size K and given helical propensities [Formula: see text] on a conformational phase space. Second, we focus our attention to a particular set of neuropentapeptides, [Met-5] and [Leu-5] enkephalins whose thermodynamic stability is a key feature on their coupling to [Formula: see text] and [Formula: see text] receptors and the triggering of biochemical responses.

  14. Influence of Fiber Orientation on Single-Point Cutting Fracture Behavior of Carbon-Fiber/Epoxy Prepreg Sheets

    Directory of Open Access Journals (Sweden)

    Yingying Wei

    2015-10-01

    Full Text Available The purpose of this article is to investigate the influences of carbon fibers on the fracture mechanism of carbon fibers both in macroscopic view and microscopic view by using single-point flying cutting method. Cutting tools with three different materials were used in this research, namely, PCD (polycrystalline diamond tool, CVD (chemical vapor deposition diamond thin film coated carbide tool and uncoated carbide tool. The influence of fiber orientation on the cutting force and fracture topography were analyzed and conclusions were drawn that cutting forces are not affected by cutting speeds but significantly influenced by the fiber orientation. Cutting forces presented smaller values in the fiber orientation of 0/180° and 15/165° but the highest one in 30/150°. The fracture mechanism of carbon fibers was studied in different cutting conditions such as 0° orientation angle, 90° orientation angle, orientation angles along fiber direction, and orientation angles inverse to the fiber direction. In addition, a prediction model on the cutting defects of carbon fiber reinforced plastic was established based on acoustic emission (AE signals.

  15. Accurate mitochondrial DNA sequencing using off-target reads provides a single test to identify pathogenic point mutations.

    Science.gov (United States)

    Griffin, Helen R; Pyle, Angela; Blakely, Emma L; Alston, Charlotte L; Duff, Jennifer; Hudson, Gavin; Horvath, Rita; Wilson, Ian J; Santibanez-Koref, Mauro; Taylor, Robert W; Chinnery, Patrick F

    2014-12-01

    Mitochondrial disorders are a common cause of inherited metabolic disease and can be due to mutations affecting mitochondrial DNA or nuclear DNA. The current diagnostic approach involves the targeted resequencing of mitochondrial DNA and candidate nuclear genes, usually proceeds step by step, and is time consuming and costly. Recent evidence suggests that variations in mitochondrial DNA sequence can be obtained from whole-exome sequence data, raising the possibility of a comprehensive single diagnostic test to detect pathogenic point mutations. We compared the mitochondrial DNA sequence derived from off-target exome reads with conventional mitochondrial DNA Sanger sequencing in 46 subjects. Mitochondrial DNA sequences can be reliably obtained using three different whole-exome sequence capture kits. Coverage correlates with the relative amount of mitochondrial DNA in the original genomic DNA sample, heteroplasmy levels can be determined using variant and total read depths, and-providing there is a minimum read depth of 20-fold-rare sequencing errors occur at a rate similar to that observed with conventional Sanger sequencing. This offers the prospect of using whole-exome sequence in a diagnostic setting to screen not only all protein coding nuclear genes but also all mitochondrial DNA genes for pathogenic mutations. Off-target mitochondrial DNA reads can also be used to assess quality control and maternal ancestry, inform on ethnic origin, and allow genetic disease association studies not previously anticipated with existing whole-exome data sets.

  16. Comparison of plastic strains on AA5052 by single point incremental forming process using digital image processing

    Energy Technology Data Exchange (ETDEWEB)

    Mugendiran, V.; Gnanavelbabu, A. [Anna University, Chennai, Tamilnadu (India)

    2017-06-15

    In this study, a surface based strain measurement was used to determine the formability of the sheet metal. A strain measurement may employ manual calculation of plastic strains based on the reference circle and the deformed circle. The manual calculation method has a greater margin of error in the practical applications. In this paper, an attempt has been made to compare the formability by implementing three different theoretical approaches: Namely conventional method, least square method and digital based strain measurements. As the sheet metal was formed by a single point incremental process the etched circles get deformed into elliptical shapes approximately, image acquisition has been done before and after forming. The plastic strains of the deformed circle grids are calculated based on the non- deformed reference. The coordinates of the deformed circles are measured by various image processing steps. Finally the strains obtained from the deformed circle are used to plot the forming limit diagram. To evaluate the accuracy of the system, the conventional, least square and digital based method of prediction of the forming limit diagram was compared. Conventional method and least square method have marginal error when compared with digital based processing method. Measurement of strain based on image processing agrees well and can be used to improve the accuracy and to reduce the measurement error in prediction of forming limit diagram.

  17. PIV study of non-Marangoni surface flows in thin liquid films induced by single- and multi-point thermodes

    Science.gov (United States)

    Cui, Nai-Yi; Wang, Song-Po

    2018-03-01

    The non-Marangoni directional flows, which can occur in only very thin liquid films, have been studied using particle image velocimetry techniques. Single- and multi-point thermodes have been used in this study for generating the flows. The results show that the direction of these flows is governed by the variation trend of the thickness of the film and the shape of the temperature profile. A hot thermode always drives a thick-to-thin flow, whereas a cold thermode always drives a flow in the opposite direction. Increasing the temperature difference between the thermode and the ambience, or decreasing the thickness of the liquid film, can accelerate the flow speed. However, the flow speed cannot exceed an upper limit. When more than one thermode was used, different flow patterns, including thick-to-thin streams driven by hot thermodes and thin-to-thick streams driven by cold thermodes, could be formed. The experimental results strongly suggest that these flows were not driven by thermo-capillary forces but by a newly proposed thermo-dynamic mechanism.

  18. The affective turn in ethnomusicology

    Directory of Open Access Journals (Sweden)

    Hofman Ana

    2015-01-01

    Full Text Available The affective turn, which has already questioned dominant paradigms in many disciplinary fields including cultural studies, philosophy, political theory, anthropology, psychology and neuroscience, has started to attract more attention in the field of ethnomusicology, becoming a particularly vibrant stream of thought. Drawing on the voices that call for the historicisation of and critical deliberation on the field of affect studies, the article strives to show how theories of affect might expand dominant paradigms in ethnomusicology and also points to their limitations.

  19. Turning Sunlight into Electricity

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 11; Issue 7. Turning Sunlight into Electricity - Inorganic Solar Cells and Beyond. A K Shukla. General Article Volume 11 Issue 7 July 2006 pp 42-50. Fulltext. Click here to view fulltext PDF. Permanent link:

  20. Turning lead into gold

    DEFF Research Database (Denmark)

    Jensen, Steffen Moltrup Ernø

    For years the field of entrepreneurship has been blinded by the alchemical promise of turning lead into gold, of finding the ones most likely to become the next Branson, Zuckerberg or Gates. The promise has been created in the midst of political and scientific agendas where certain individuals...

  1. Turning to alcohol?

    International Nuclear Information System (INIS)

    Reiboro, S.K.

    1998-01-01

    Brazil is examining whether turning to alcohol could solve its problems. The fuel alcohol producers are lobbying hard for the government to increase the use of alcohol to fuel the country's cars. Not only does using alcohol reduce CO 2 , runs the argument, but the Kyoto agreement might just attract international financing for the project. (author)

  2. Low-pressure, single-point grout injection for tank heel sludge mixing and in-situ immobilization

    International Nuclear Information System (INIS)

    Whyatt, G.A.; Hymas, C.R.

    1998-09-01

    This report describes tests conducted in an approximately 9-ft diameter test tank situated outside the 336 building in Hanford's 300 area. The tests were performed to measure the ability of jets of grout slurry to mobilize and mix simulated tank sludge. The technique is intended for in situ immobilization of tank waste heels. The current approach uses a single, rotated, larger-diameter nozzle driven at lower pressure. Due to the larger diameter, the potential for plugging is reduced and the effective radius around an injection point over which the jet is effective in mobilizing sludge from the tank bottom can be made larger. A total of three grout injection tests were conducted in a 9-ft diameter tank. In each case, a 2-in. layer of kaolin clay paste was placed on a dry tank floor to simulate a sludge heel. The clay was covered with 4 inches of water. The grout slurry, consisting of Portland cement, class F fly ash, and eater, was prepared and delivered by an offsite vendor. In the third test, the sludge in half of the tank was replaced by a layer of 20x50 mesh zeolite, and bentonite clay was added to the grout formulation. After injection, the grout was allowed to set and then the entire grout monolith was manually broken up and excavated using a jack hammer. Intact pieces of clay were visually apparent due to a sharp color contrast between the grout and clay. Remaining clay deposits were collected and weighed and suspended clay pieces within the monolith were photographed. The mobilization performance of the grout jets exceeded expectations

  3. Van Allen Probes Science Gateway: Single-Point Access to Long-Term Radiation Belt Measurements and Space Weather Nowcasting

    Science.gov (United States)

    Romeo, G.; Barnes, R. J.; Ukhorskiy, A. Y.; Sotirelis, T.; Stephens, G.

    2017-12-01

    The Science Gateway gives single-point access to over 4.5 years of comprehensive wave and particle measurements from the Van Allen Probes NASA twin-spacecraft mission. The Gateway provides a set of visualization and data analysis tools including: HTML5-based interactive visualization of high-level data products from all instrument teams in the form of: line plots, orbital content plots, dynamical energy spectra, L-shell context plots (including two-spacecraft plotting), FFT spectra of wave data, solar wind and geomagnetic indices data, etc.; download custom multi-instrument CDF data files of selected data products; publication quality plots of digital data; combined orbit predicts for mission planning and coordination including: Van Allen Probes, MMS, THEMIS, Arase (ERG), Cluster, GOES, Geotail, FIREBIRD; magnetic footpoint calculator for coordination with LEO and ground-based assets; real-time computation and processing of empirical magnetic field models - computation of magnetic ephemeris, computation of adiabatic invariants. Van Allen Probes is the first spacecraft mission to provide a nowcast of the radiation environment in the heart of the radiation belts, where the radiation levels are the highest and most dangerous for spacecraft operations. For this purpose, all instruments continuously broadcast a subset of their science data in real time. Van Allen Probes partners with four foreign institutions who operate ground stations that receive the broadcast: Korea (KASI), the Czech republic (CAS), Argentina (CONAE), and Brazil (INPE). The SpWx broadcast is then collected at APL and delivered to the community via the Science Gateway.

  4. Assessment of left ventricular function with single breath-hold highly accelerated cine MRI combined with guide-point modeling

    International Nuclear Information System (INIS)

    Heilmaier, Christina; Nassenstein, Kai; Nielles-Vallespin, Sonia; Zuehlsdorff, Sven; Hunold, Peter; Barkhausen, Joerg

    2010-01-01

    Purpose: To prospectively assess the performance of highly accelerated cine MRI in multi-orientations combined with a new guide-point modeling post-processing technique (GPM approach) for assessment of left ventricular (LV) function compared to the standard summation of slices method based on a stack of short axis views (SoS approach). Materials and methods: 33 consecutive patients were examined on a 1.5 T scanner with a standard steady state free precession (SSFP) sequence (TR, 3.0 ms; TE, 1.5 m; flip angle (FA), 60 o ; acceleration factor (AF), 2) analyzed with the SoS method and a highly accelerated, single breath-hold temporal parallel acquisition SSFP sequence (TR, 4.6 ms; TE, 1.1 ms; AF, 3) post-processed with the GPM method. LV function values were measured by two independent readers with different experience in cardiac MRI and compared by using the paired t-test and F-test. Inter- and intraobserver agreements were calculated using Bland-Altman-Plots. Results: Mean acquisition and post-processing time was significantly shorter with the GPM approach (15 s/3 min versus 360 s/6 min). For all LV function parameters interobserver agreement between the experienced and non-experienced reader was significantly improved when the GPM approach was used. However, end-diastolic and end-systolic volumes were larger for the GPM technique when compared to the SoS method (P 0.121). In both readers and for all parameters variances did not differ significantly (P ≥ 0.409) and the two approaches showed an excellent linear correlation (r > 0.951). Conclusion: Due to its accurate, fast and reproducible assessment of LV function parameters highly accelerated MRI combined with the GPM technique may become the technique of first choice for assessment of LV function in clinical routine.

  5. An elevated neutrophil-lymphocyte ratio is associated with adverse outcomes following single time-point paracetamol (acetaminophen) overdose: a time-course analysis.

    Science.gov (United States)

    Craig, Darren G; Kitto, Laura; Zafar, Sara; Reid, Thomas W D J; Martin, Kirsty G; Davidson, Janice S; Hayes, Peter C; Simpson, Kenneth J

    2014-09-01

    The innate immune system is profoundly dysregulated in paracetamol (acetaminophen)-induced liver injury. The neutrophil-lymphocyte ratio (NLR) is a simple bedside index with prognostic value in a number of inflammatory conditions. To evaluate the prognostic accuracy of the NLR in patients with significant liver injury following single time-point and staggered paracetamol overdoses. Time-course analysis of 100 single time-point and 50 staggered paracetamol overdoses admitted to a tertiary liver centre. Timed laboratory samples were correlated with time elapsed after overdose or admission, respectively, and the NLR was calculated. A total of 49/100 single time-point patients developed hepatic encephalopathy (HE). Median NLRs were higher at both 72 (P=0.0047) and 96 h after overdose (P=0.0041) in single time-point patients who died or were transplanted. Maximum NLR values by 96 h were associated with increasing HE grade (P=0.0005). An NLR of more than 16.7 during the first 96 h following overdose was independently associated with the development of HE [odds ratio 5.65 (95% confidence interval 1.67-19.13), P=0.005]. Maximum NLR values by 96 h were strongly associated with the requirement for intracranial pressure monitoring (Poverdose cohort, the NLR was not associated with adverse outcomes or death/transplantation either at admission or subsequently. The NLR is a simple test which is strongly associated with adverse outcomes following single time-point, but not staggered, paracetamol overdoses. Future studies should assess the value of incorporating the NLR into existing prognostic and triage indices of single time-point paracetamol overdose.

  6. Centrifugal multiplexing fixed-volume dispenser on a plastic lab-on-a-disk for parallel biochemical single-end-point assays.

    Science.gov (United States)

    La, Moonwoo; Park, Sang Min; Kim, Dong Sung

    2015-01-01

    In this study, a multiple sample dispenser for precisely metered fixed volumes was successfully designed, fabricated, and fully characterized on a plastic centrifugal lab-on-a-disk (LOD) for parallel biochemical single-end-point assays. The dispenser, namely, a centrifugal multiplexing fixed-volume dispenser (C-MUFID) was designed with microfluidic structures based on the theoretical modeling about a centrifugal circumferential filling flow. The designed LODs were fabricated with a polystyrene substrate through micromachining and they were thermally bonded with a flat substrate. Furthermore, six parallel metering and dispensing assays were conducted at the same fixed-volume (1.27 μl) with a relative variation of ±0.02 μl. Moreover, the samples were metered and dispensed at different sub-volumes. To visualize the metering and dispensing performances, the C-MUFID was integrated with a serpentine micromixer during parallel centrifugal mixing tests. Parallel biochemical single-end-point assays were successfully conducted on the developed LOD using a standard serum with albumin, glucose, and total protein reagents. The developed LOD could be widely applied to various biochemical single-end-point assays which require different volume ratios of the sample and reagent by controlling the design of the C-MUFID. The proposed LOD is feasible for point-of-care diagnostics because of its mass-producible structures, reliable metering/dispensing performance, and parallel biochemical single-end-point assays, which can identify numerous biochemical.

  7. Hungary's U-Turn

    OpenAIRE

    Kornai, János

    2015-01-01

    For two decades Hungary, like the other Eastern European countries, followed a general policy of establishing and strengthening the institutions of democracy, rule of law, and a market economy based on private property. However, since the elections of 2010, when Viktor Orbán's Fidesz party came to power, Hungary has made a dramatic U-turn. This article investigates the different spheres of society: political institutions, the rule of law, and the influence of state and market on one another, ...

  8. Turning Desirements into Requirements

    Science.gov (United States)

    2015-09-01

    27 Defense AT&L: September–October 2015 Turning “Desirements” into Requirements Charles Court Court is the Requirements Center Director at the...Defense Systems Management College at the Defense Acquisition University at Fort Belvoir, Virginia. He is a former Wild Weasel Electronic Warfare Officer...a Mustang would do much better. (The author wanted the Aston Martin from the movie “Goldfinger.” You know: The one with the ejection seat, automated

  9. CONNECTION OF TURN AHEAD AND TURN BACK WITH MOTORIC ABILITIES OF THE FIFTH GRADE STUDENTS

    Directory of Open Access Journals (Sweden)

    Jovica Petković

    2006-06-01

    Full Text Available The research is done for the purpose of determination and defining of the level of connection between some motoric abilities with success in realization of programmed contents from the area of gymnastics (turn ahead and turn back. The research is done on the sample of fifty one students from the fifth grade of Elementary School, on ten motoric tests and on two specific motoric assignments – turn ahead and turn back. The results of this research clearly point that there exist the multitude of statistically important coefficients of correlation between treated motoric abilities and applied motoric assignments.

  10. Fixed Points of Single- and Set-Valued Mappings in Uniformly Convex Metric Spaces with No Metric Convexity

    Directory of Open Access Journals (Sweden)

    Rafa Espínola

    2010-01-01

    Full Text Available We study the existence of fixed points and convergence of iterates for asymptotic pointwise contractions in uniformly convex metric spaces. We also study the existence of fixed points for set-valued nonexpansive mappings in the same class of spaces. Our results do not assume convexity of the metric which makes a big difference when studying the existence of fixed points for set-valued mappings.

  11. A generic-tee-plenum mixing system for application to single point aerosol sampling in stacks and ducts.

    Science.gov (United States)

    Han, Taewon; O'Neal, Dennis L; Ortiz, Carlos A

    2007-01-01

    The ANSI/HPS-N13.1-1999 standard is based on the concept of obtaining a single point representative sample from a location where the velocity and contaminant profiles are relatively uniform. It is difficult to predict the level of mixing in an arbitrary stack or duct without experimental data to meet the ANSI/HPS N13.1-1999 requirements. The goal of this study was to develop experimental data for a range of conditions in "S" (S-shaped configuration) duct systems with different mixing elements and "S" systems having one or two mixing elements. Results were presented in terms of the coefficients of variation (COVs) for velocity, tracer gas, and 10-mum aerodynamic diameter (AD) aerosol particle profiles at different downstream locations for each mixing element. Five mixing elements were tested, including a 90 degrees elbow, a commercial static mixer, a Small-Horizontal Generic-Tee-Plenum (SH-GTP), a Small-Vertical Generic-Tee-Plenum (SV-GTP), and a Large-Horizontal Generic-Tee-Plenum (LH-GTP) system. The COVs for velocity, gas concentration, and aerosol particles for the three GTP systems were all determined to be less than 8%. Tests with two different sizes of GTPs were conducted, and the results showed the performance of the GTPs was relatively unaffected by either size or velocity as reflected by the Reynolds number. The pressure coefficients were 0.59, 0.57, and 0.65, respectively, for the SH-GTP, SV-GTP, and LH-GTP. The pressure drop for the GTPs was approximately twice that of the round elbow, but a factor of 5 less than a Type IV Air Blender. The GTP was developed to provide a sampling location less than 4-duct diameters downstream of a mixing element with low pressure drop condition. The object of the developmental effort was to provide a system that could be employed in new stack; however, the concept of GTPs could also be retrofitted onto existing system applications as well. Results from these tests show that the system performance is well within the ANSI

  12. X Marks the Spot: Creating and Managing a Single Service Point to Improve Customer Service and Maximize Resources

    Science.gov (United States)

    Venner, Mary Ann; Keshmiripour, Seti

    2016-01-01

    This article will describe how merging service points in an academic library is an opportunity to improve customer service and utilize staffing resources more efficiently. Combining service points provides libraries with the ability to create a more positive library experience for patrons by minimizing the ping-pong effect for assistance. The…

  13. Turn Openings in Academic Talk: Where Goals and Roles Intersect

    Science.gov (United States)

    Evison, Jane

    2013-01-01

    This study uses Corpus Linguistic (CL) techniques to explore multiple turn openings in conjunction with comparative measures of turn-initial priming (the proportion of occurrences of a form that are turn-initial). Using a benchmark corpus of casual conversation as a point of comparison, six frequent items which have a particularly strong affinity…

  14. Turning scar into muscle.

    Science.gov (United States)

    de Carvalho, Antonio Carlos Campos; Carvalho, Adriana Bastos

    2012-09-26

    After the demonstration that somatic cells could be reprogrammed to a pluripotent state, exciting new prospects were opened for the cardiac regeneration field. It did not take long for the development of strategies to convert somatic cells directly into cardiomyocytes. Despite the intrinsic difficulties of cell reprogramming, such as low efficiency, the therapeutic possibilities created by the ability to turn scar into muscle are enormous. Here, we discuss some of the major advances and strategies used in direct cardiac reprogramming and examine discrepancies and concerns that still need to be resolved in the field.

  15. Dynamics of single photon transport in a one-dimensional waveguide two-point coupled with a Jaynes-Cummings system

    KAUST Repository

    Wang, Yuwen

    2016-09-22

    We study the dynamics of an ultrafast single photon pulse in a one-dimensional waveguide two-point coupled with a Jaynes-Cummings system. We find that for any single photon input the transmissivity depends periodically on the separation between the two coupling points. For a pulse containing many plane wave components it is almost impossible to suppress transmission, especially when the width of the pulse is less than 20 times the period. In contrast to plane wave input, the waveform of the pulse can be modified by controlling the coupling between the waveguide and Jaynes-Cummings system. Tailoring of the waveform is important for single photon manipulation in quantum informatics. © The Author(s) 2016.

  16. Tipping point leadership.

    Science.gov (United States)

    Kim, W Chan; Mauborgne, Renée

    2003-04-01

    When William Bratton was appointed police commissioner of New York City in 1994, turf wars over jurisdiction and funding were rife and crime was out of control. Yet in less than two years, and without an increase in his budget, Bratton turned New York into the safest large city in the nation. And the NYPD was only the latest of five law-enforcement agencies Bratton had turned around. In each case, he succeeded in record time despite limited resources, a demotivated staff, opposition from powerful vested interests, and an organization wedded to the status quo. Bratton's turnarounds demonstrate what the authors call tipping point leadership. The theory of tipping points hinges on the insight that in any organization, fundamental changes can occur quickly when the beliefs and energies of a critical mass of people create an epidemic movement toward an idea. Bratton begins by overcoming the cognitive hurdles that block organizations from recognizing the need for change. He does this by putting managers face-to-face with operational problems. Next, he manages around limitations on funds, staff, or equipment by concentrating resources on the areas that are most in need of change and that have the biggest payoffs. He meanwhile solves the motivation problem by singling out key influencers--people with disproportionate power due to their connections or persuasive abilities. Finally, he closes off resistance from powerful opponents. Not every CEO has the personality to be a Bill Bratton, but his successes are due to much more than his personality. He relies on a remarkably consistent method that any manager looking to turn around an organization can use to overcome the forces of inertia and reach the tipping point.

  17. Fermilab turns 50! Congratulations!

    CERN Multimedia

    Staff Association

    2017-01-01

    This year Fermilab turns 50 and the celebrations are ongoing. The ties between CERN and Fermilab are numerous and have been ranging from competition between two labs at the forefront of their field, e.g. with the chase of the top quark, finally discovered by Fermilab, to outright collaboration, e.g. on LHC low-beta quadrupole magnet development and production and in the CMS collaboration. In June, in the name of the CERN staff and scientific community, the CERN Staff Association sent a message to the Fermilab staff and scientific community, through Dr. Nigel Lockyer, Fermilab Director. The letter, and the assurance from Nigel Lockyer that the message has been passed onto the Fermilab community can be found on our website. Congratulations to Fermilab on its fiftieth Anniversary, and to the staff and collaborators who made this laboratory through their hard work, dedication and vision!

  18. The Affective Turn

    Directory of Open Access Journals (Sweden)

    Alí Lara

    2013-11-01

    Full Text Available In the last decade studies on affect and emotions have become relevant in the social sciences. This is not just a fad guideline, but instead a simultaneous reader of public life changes and subjective experience, from which it is also being transformed the knowledge production. Such a trend has been known as ‘The Affective Turn’ within the Anglophone Academy. Here we will translate it as ‘El Giro Afectivo’. This turn, so far, has not dabbled in the social science literature that is written in Spanish. This paper draws on a singular panorama of discussions about contemporary social studies of affect and emotion, and it’s vertebrate by some of its expressions in the contemporary academy.

  19. FoCuS-point: software for STED fluorescence correlation and time-gated single photon counting

    DEFF Research Database (Denmark)

    Waithe, Dominic; Clausen, Mathias P; Sezgin, Erdinc

    2016-01-01

    microscopy (STED-FCS). Specifically, the use of gated detection has shown great potential for enhancing STED-FCS, but has also created a demand for software which is efficient and also implements the latest algorithms. Prior to this study, no open software has been available which would allow practical time...... to be established quickly and efficiently. AVAILABILITY AND IMPLEMENTATION: FoCuS-point is written in python and is available through the github repository: https://github.com/dwaithe/FCS_point_correlator. Furthermore, compiled versions of the code are available as executables which can be run directly in Linux...

  20. Phase transitions and multicritical points in the mixed spin-32 and spin-2 Ising system with a single-ion anisotropy

    International Nuclear Information System (INIS)

    Bobak, A.; Dely, J.

    2007-01-01

    The effect of a single-ion anisotropy on the phase diagram of the mixed spin-32 and spin-2 Ising system is investigated by the use of a mean-field theory based on the Bogoliubov inequality for the free energy. Topologically different kinds of phase diagrams are achieved by changing values of the parameter in the model Hamiltonian. Besides second-order transitions, lines of first-order transitions terminating either at a tricritical point or an isolated critical point, are found

  1. Reshape of the bunch-by-bunch BPM signal to turn-by-turn matrix during the fast rf frequency sweeping time in Booster

    International Nuclear Information System (INIS)

    Yang, Xi; Ankenbrandt, Charles M.; Lackey, James; Scarpine, Vic

    2004-01-01

    The bunch-by-bunch BPM signal array has to be reshaped into a turn-by-turn (TBT) matrix in order to make the TBT beam position information of a single bunch available for further data analysis, such as via the Fourier transform to obtain the synchrotron tune and betatron tune, etc. Since the RF frequency sweeps more than 10 MHz in the first 8 ms of a Booster cycle, the revolution time decreases more than 20%. The number of data points for each Booster turn (BT) should be varied in the same pace with the revolution time since the sampling rate of a digital oscilloscope is usually fixed. And this can be done by pre-determining the relationship between the RF frequency and the time in a cycle via the curve fit

  2. Turning Sunlight into Electricity

    Indian Academy of Sciences (India)

    module' or a 'solar panel' that provides a useful voltage and current. The efficiency of silicon solar cells for the conversion of light energy to electricity has increased steadily over the years to present values of up to 18% for amorphous silicon, and 25% for single crystal cells. At the same time, the cost of cells has fallen.

  3. Childrens' left-turning preference is not modulated by magical ideation.

    Science.gov (United States)

    Streuli, Jürg C; Obrist, Gina; Brugger, Peter

    2017-01-01

    The literature on human turning preferences is inconsistent. While the few studies with children below 14 years of age uniformly describe an overall left-turning (counterclockwise) tendency, a recent Internet study with more than 1500 adults found a right-sided (clockwise) bias. We set out to investigate spontaneous turning behaviour in children age 5-3 years and, based on neuropsychiatric work in adults, also explored a potential association with magical thinking. Findings indicated a clear left-turning preference, independent of a participant's sex and handedness. Whether a child responded a question about the existence of extrasensory communication in the affirmative or not was unrelated to direction and size of turning bias and lateral preference. Our results are consistent with a left-sided turning preference reported for children, but in opposition to the clockwise bias recently described in a large-scale study with adults. Whether they point to a maturational gradient in the preferred direction of spontaneous whole-body rotation or rather to a lack of comparability between measures used in observational versus Internet-based studies remains to be further investigated. Regarding a purported association between body turns and magical thinking, our study is preliminary, as only one single question was used to probe the latter.

  4. SU-E-T-263: Point Dose Variation Using a Single Ir-192 HDR Brachytherapy Plan for Two Treatments with a Single Tandem-Ovoid Insertion for Cervical Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Liang, X; Morrill, S; Hardee, M; Han, E; Penagaricano, J; Zhang, X; Vaneerat, R [University of Arkansas Medical Science, Little Rock, AR (United States)

    2014-06-01

    Purpose: To evaluate the point dose variations between Ir-192 HDR treatments on two consecutive days using a single tandem-ovoid insertion without replanning in cervical cancer patients. Methods: This study includes eleven cervical cancer patients undergoing HDR brachytherapy with a prescribed dose of 28 Gy in 4 fractions. Each patient had two tandemovoid insertions one week apart. Each insertion was treated on consecutive days with rescanning and replanning prior to each treatment. To study the effect of no replanning for day 2 treatments, the day 1 plan dwell position and dwell time with decay were applied to the day 2 CT dataset. The point dose variations on the prescription point H (defined according to American Brachytherapy Society), and normal tissue doses at point B, bladder, rectum and vaginal mucosa (based on ICRU Report 38) were obtained. Results: Without replanning, the mean point H dose variation was 4.6 ± 10.7% on the left; 2.3 ± 2.9% on the right. The mean B point variation was 3.8 ± 4.9% on the left; 3.6 ± 4.7% on the right. The variation in the left vaginal mucosal point was 12.2 ± 10.7%; 9.5 ± 12.5% on the right; the bladder point 5.5 ± 7.4%; and the rectal point 7.9 ± 9.1%. Conclusion: Without replanning, there are variations both in the prescription point and the normal tissue point doses. The latter can vary as much as 10% or more. This is likely due to the steep dose gradient from brachytherapy compounded by shifts in the positions of the applicator in relationship to the patients anatomy. Imaging prior to each treatment and replanning ensure effective and safe brachytherapy are recommended.

  5. Simultaneous estimation of population receptive field and hemodynamic parameters from single point BOLD responses using Metropolis-Hastings sampling.

    Science.gov (United States)

    Adaszewski, Stanisław; Slater, David; Melie-Garcia, Lester; Draganski, Bogdan; Bogorodzki, Piotr

    2018-01-30

    We introduce a new approach to Bayesian pRF model estimation using Markov Chain Monte Carlo (MCMC) sampling for simultaneous estimation of pRF and hemodynamic parameters. To obtain high performance on commonly accessible hardware we present a novel heuristic consisting of interpolation between precomputed responses for predetermined stimuli and a large cross-section of receptive field parameters. We investigate the validity of the proposed approach with respect to MCMC convergence, tuning and biases. We compare different combinations of pRF - Compressive Spatial Summation (CSS), Dumoulin-Wandell (DW) and hemodynamic (5-parameter and 3-parameter Balloon-Windkessel) models within our framework with and without the usage of the new heuristic. We evaluate estimation consistency and log probability across models. We perform as well a comparison of one model with and without lookup table within the RStan framework using its No-U-Turn Sampler. We present accelerated computation of whole-ROI parameters for one subject. Finally, we discuss risks and limitations associated with the usage of the new heuristic as well as the means of resolving them. We found that the new algorithm is a valid sampling approach to joint pRF/hemodynamic parameter estimation and that it exhibits very high performance. Copyright © 2018. Published by Elsevier Inc.

  6. Comparison of single point normalized and modified Gate's method for measurement of glomerular filtration rate by nuclear medicine

    International Nuclear Information System (INIS)

    Fonseca, L.M.B. da; Fonseca, N.M.; Martins, E.; Pereira, E.

    1992-01-01

    Glomerular filtration rate was measured in 22 patients (mean age 30 years) using a noninvasive modified Gates method and the results were compared to the one point normalized technique. The values obtained were 74-11.7 and 82-11.09 ml/min., respectively. The advantages of the method are its reliability, easy adaptation to small laboratories and the avoidance of blood and urine sampling. (author)

  7. Bodily-visual practices and turn continuation.

    Science.gov (United States)

    Ford, Cecilia E; Thompson, Sandra A; Drake, Veronika

    2012-01-01

    This paper considers points in turn construction where conversation researchers have shown that talk routinely continues beyond possible turn completion, but where we find bodily-visual behavior doing such turn extension work. The bodily-visual behaviors we examine share many features with verbal turn extensions, but we argue that embodied movements have distinct properties that make them well-suited for specific kinds of social action, including stance display and by-play in sequences framed as subsidiary to a simultaneous and related verbal exchange. Our study is in line with a research agenda taking seriously the point made by Goodwin (2000a, b, 2003), Hayashi (2003, 2005), Iwasaki (2009), and others that scholars seeking to account for practices in language and social interaction do themselves a disservice if they privilege the verbal dimension; rather, as suggested in Stivers/Sidnell (2005), each semiotic system/modality, while coordinated with others, has its own organization. With the current exploration of bodily-visual turn extensions, we hope to contribute to a growing understanding of how these different modes of organization are managed concurrently and in concert by interactants in carrying out their everyday social actions.

  8. Bee venom acupuncture point injection for central post stroke pain: a preliminary single-blind randomized controlled trial.

    Science.gov (United States)

    Cho, Seung-Yeon; Park, Joo-Young; Jung, Woo-Sang; Moon, Sang-Kwan; Park, Jung-Mi; Ko, Chang-Nam; Park, Seong-Uk

    2013-06-01

    We investigated apipuncture, or acupuncture point injection with diluted bee venom, as a promising new treatment for central post stroke pain (CPSP). Bee venom, diluted to 0.005% in normal saline, was administered to the treatment group, and normal saline given to control group as twice-weekly injections for three weeks. The points were LI15, GB21, LI11, GB31, ST36 and GB39 of the affected side and the amount of injection was 0.05 ml at each point. Eight patients in each group were included in the analysis. After three weeks there were significant decreases in visual analogue pain scores compared with baseline in both groups and the treatment group improved more significantly than the control group (p = 0.009). Apipuncture significantly improved CPSP in this pilot trial. Further studies of its mechanisms and a larger and long-term follow-up trial will be needed to determine more definitely the efficacy of apipuncture and to elucidate duration of improvement. Copyright © 2013 Elsevier Ltd. All rights reserved.

  9. Enhancing the accuracy of GPS point positioning by converting the single frequency data to dual frequency data

    Directory of Open Access Journals (Sweden)

    Aly M. El-naggar

    2011-09-01

    Full Text Available The global positioning system (GPS has been used to support a wide variety of applications, such as high-accuracy positioning and navigation. Differential GPS techniques can largely eliminate common-mode errors between the reference and the rover GPS stations resulting from ionospheric and tropospheric refraction and delays, satellite and receiver clock biases, and orbital errors [1]. The ionospheric delay in the propagation of global positioning system (GPS signals is one of the main sources of error in GPS precise positioning and navigation. A dual-frequency GPS receiver can eliminate (to the first order the ionospheric delay through a linear combination of the L1 and L2 observations [2]. The most significant effect of ionospheric delay appear in case of using single frequency data. In this paper the single frequency data of concerned station are converted to dual frequency data by employing dual frequency data from 11 regional GPS stations distributed around it. Total electron content (TEC was calculated at every GPS station to produce the mathematical model of TEC which is a function of latitude (Φ and longitude (λ. By using this mathematical model the values of TEC and L2 can be predicted at the single frequency GPS station for each satellite, after that the comparison between predicted and observation values of TEC and L2 was performed. The estimation method and test results of the proposed method indicates that the difference between predicted and observation values is very small.

  10. First year's operation experience of the deepest SPM (Single Point Mooring) in the world

    Energy Technology Data Exchange (ETDEWEB)

    Millar, J.L.; Hughes, H.; Dyer, R.C.

    1979-01-01

    The British National Oil Corp. had a Single Anchor Leg Mooring (SALM) installed at the Thistle Field in Apr. 1977 for export loading of tankers pending completion of the Brent System 36 in. pipeline to Sullom-Voe, which became operational in Dec. 1978; the SALM will continue to be maintained in good condition as a standby alternative export outlet. Modification of the original three 80,000 dwt tankers during 1977 provided the original design capacity of an 80,000 dwt tanker, but with added clean ballast capacity to eliminate tank cleaning and treatment of dirty ballast water. A fully integrated tanker/SALM/platform instrumentation system monitors mooring loads, buoy and riser angles, and tanker status; the latter being radio telemetered to the nearby block platform. Operation of the system and necessary modifications are described.

  11. Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution.

    Science.gov (United States)

    Ling, Shaoping; Hu, Zheng; Yang, Zuyu; Yang, Fang; Li, Yawei; Lin, Pei; Chen, Ke; Dong, Lili; Cao, Lihua; Tao, Yong; Hao, Lingtong; Chen, Qingjian; Gong, Qiang; Wu, Dafei; Li, Wenjie; Zhao, Wenming; Tian, Xiuyun; Hao, Chunyi; Hungate, Eric A; Catenacci, Daniel V T; Hudson, Richard R; Li, Wen-Hsiung; Lu, Xuemei; Wu, Chung-I

    2015-11-24

    The prevailing view that the evolution of cells in a tumor is driven by Darwinian selection has never been rigorously tested. Because selection greatly affects the level of intratumor genetic diversity, it is important to assess whether intratumor evolution follows the Darwinian or the non-Darwinian mode of evolution. To provide the statistical power, many regions in a single tumor need to be sampled and analyzed much more extensively than has been attempted in previous intratumor studies. Here, from a hepatocellular carcinoma (HCC) tumor, we evaluated multiregional samples from the tumor, using either whole-exome sequencing (WES) (n = 23 samples) or genotyping (n = 286) under both the infinite-site and infinite-allele models of population genetics. In addition to the many single-nucleotide variations (SNVs) present in all samples, there were 35 "polymorphic" SNVs among samples. High genetic diversity was evident as the 23 WES samples defined 20 unique cell clones. With all 286 samples genotyped, clonal diversity agreed well with the non-Darwinian model with no evidence of positive Darwinian selection. Under the non-Darwinian model, MALL (the number of coding region mutations in the entire tumor) was estimated to be greater than 100 million in this tumor. DNA sequences reveal local diversities in small patches of cells and validate the estimation. In contrast, the genetic diversity under a Darwinian model would generally be orders of magnitude smaller. Because the level of genetic diversity will have implications on therapeutic resistance, non-Darwinian evolution should be heeded in cancer treatments even for microscopic tumors.

  12. Papilla height in relation to the distance between bone crest and interproximal contact point at single-tooth implants: A systematic review.

    Science.gov (United States)

    Roccuzzo, Mario; Roccuzzo, Andrea; Ramanuskaite, Ausra

    2018-03-01

    The aim of this systematic review was to investigate the tooth-implant papilla formation in correlation with the distance between the interproximal bone level and the prosthetic contact point. A comprehensive search of the current literature (01/01/2000-01/01/2017) was performed to identify human trials that included 10 patients or more, with at least 12 months follow-up, in need of the replacement of one single tooth in the anterior maxillary region with an implant-supported single crown. To meet the inclusion criteria, studies had to provide both radiographic and clinical data regarding the distance between the interproximal bone level and the prosthetic contact point. The search yielded 136 records. After evaluation of abstracts and full texts, 12 papers were included in the final review, even though various reference points, for the comparison between the vertical distance and the papilla height, were used. The vertical distance between the interproximal bone level and prosthetic contact point ranged between 2 and 11 mm, and the partial or complete papilla fill (Jemt's score 2-3) ranged between 56.5% and 100% of cases. There is limited evidence that the vertical distance from the base of the interproximal contact point to the crestal bone level seems to affect the interproximal papilla height; that is, the lower is the distance the higher is the percentage of papilla fill. Complete embrasure fill between an implant restoration and the adjacent tooth seems to be correlated with the integrity of the periodontal ligament of the tooth. To reduce the risk of aesthetic failures, interproximal probing on the adjacent teeth should be encouraged before implant placement. © 2018 The Authors. Clinical Oral Implants Research Published by John Wiley & Sons Ltd.

  13. Performance evaluation of thermally treated graphite felt electrodes for vanadium redox flow battery and their four-point single cell characterization

    Science.gov (United States)

    Mazúr, P.; Mrlík, J.; Beneš, J.; Pocedič, J.; Vrána, J.; Dundálek, J.; Kosek, J.

    2018-03-01

    In our contribution we study the electrocatalytic effect of oxygen functionalization of thermally treated graphite felt on kinetics of electrode reactions of vanadium redox flow battery. Chemical and morphological changes of the felts are analysed by standard physico-chemical characterization techniques. A complex method four-point method is developed and employed for characterization of the felts in a laboratory single-cell. The method is based on electrochemical impedance spectroscopy and load curves measurements of positive and negative half-cells using platinum wire pseudo-reference electrodes. The distribution of ohmic and faradaic losses within a single-cell is evaluated for both symmetric and asymmetric electrode set-up with respect to the treatment conditions. Positive effect of oxygen functionalization is observed only for negative electrode, whereas kinetics of positive electrode reaction is almost unaffected by the treatment. This is in a contradiction to the results of typically employed cyclovoltammetric characterization which indicate that both electrodes are enhanced by the treatment to a similar extent. The developed four-point characterization method can be further used e.g., for the component screening and in-situ durability studies on single-cell scale redox flow batteries of various chemistries.

  14. Wind Power: A Turning Point. Worldwatch Paper 45.

    Science.gov (United States)

    Flavin, Christopher

    Recent studies have shown wind power to be an eminently practical and potentially substantial source of electricity and direct mechanical power. Wind machines range from simple water-pumping devices made of wood and cloth to large electricity producing turbines with fiberglass blades nearly 300 feet long. Wind is in effect a form of solar…

  15. Socialization Turning Points: An Examination of Change in Organizational Identification.

    Science.gov (United States)

    Bullis, Connie; Bach, Betsy Wackernagel

    To examine perspectives of change in individual-organizational socialization, a study used the retrospective interview technique (RIT) to reconstruct the history and process of individuals' socialization experiences over an 8-month period. Using the RIT, researchers asked subjects, 28 entering graduate students enrolled in three communication…

  16. The Battle of Moscow - Turning Point of World War II

    Directory of Open Access Journals (Sweden)

    V M Falin

    2015-12-01

    Full Text Available The article is dedicated to the Battle of Moscow in October- December, 1941. Author analyzes the causes of the failure of German army, who tries to encircle and capture Moscow, the events taking place on the outskirts of Moscow, German troops attempts to encircle Moscow. The author presents data on the speech by Adolf Hitler in Berlin on October 5, 1941, in which he acknowledged the failure of the Blitzkrieg and the Battle for Moscow and its suburbs. The researcher uses the documents of the Wehrmacht High Command, which stated that after the Battle of Moscow, German troops could not on any further stage of the war to restore the quality and morale of the armed forces, with whom Reich rushed to a campaign for world domination. The author, a prominent public and political figure of the USSR, also relies on personal recollections, interviews with prominent generals of World War II, including I. Konev.

  17. [The pharmaceutical industry in France: the turning point of 1915].

    Science.gov (United States)

    Bonnemain, Bruno

    2015-12-01

    For several convergent reasons, 1915 was a key period for the pharmaceutical industry in France. The overall realization that France was dependent on Germany for chemical and pharmaceutical products came from shortages of key drugs but also from massive use of poison gas for which France was not able to face this unexpected event. France's shortage for chemists properly trained to answer the needs of industry, the weak relationship between industry and faculty, the uncomfortable situation of specialty drugs, the regulations on patents and trademarks were many subjects of controversies which will contribute to the analysis of the source of this French dependence to Germany. It will be at the origin of new orientations after the war for the pharmaceutical industry and the French society. The objective was to be independent for drugs and consequently to resolve the identified issues, as well as to have a dynamic industrial research. The creation and development of several pharmaceutical companies after the war was a more or less direct benefit from the considerations starting in 1915.

  18. FOOD VS. FUEL – A TURNING POINT FOR BIOETHANOL?

    Directory of Open Access Journals (Sweden)

    Katharina Harlander

    2008-09-01

    Full Text Available Recently concerns have been raised that biofuels would affect food prices. Bioethanol is made from sugar or starch containing plants that are also used in food production. In public perception this led to an emotional resistance against biofuels that in real terms is not substantiated. Generally, biofuels are a political product. Triggered by the oil crisis in the early 1970ies national fuel ethanol programmes were first launched in Brazil and in the United States. Concerns regarding energy security and sustainability together with the option of new markets for surplus agricultural production in recent years led to similar policy measures in the European Union and in numerous countries around the globe. Accordingly the industry invested heavily in new bioethanol plants - especially in the US – and created an additional demand for corn and wheat with some record-breaking prices noted in late 2007. A look back into statistics shows a drastic decline of real prices for decades and by now they are only back at the level of 30 years ago. One important detail is the real portion of grain used for bioethanol, which is still only 1.6 percent in the EU and therefore unlikely to be the real driver for the price development. Moreover the share of raw material is up to 70% of bioethanol production cost that makes the bioethanol industry itself a victim of price increases. Subsequently investor interest in this field slowed down, a development also watched in the US. The prospects of the agricultural markets of the European Commission conclude that Europe can do both, nutrition and biofuels.

  19. The turning point in the number of traffic fatalities

    DEFF Research Database (Denmark)

    Brüde, Ulf; Elvik, Rune

    2015-01-01

    than before. Such a change would suggest that road safety policy became more effective. Analysis of data for six countries (Denmark, Great Britain, Netherlands, Norway, Sweden, United States) lends stronger support to the latter hypothesis than to the former. The lesson for policy makers, in particular...

  20. Averroes' Physics A Turning Point in Medieval Natural Philosophy

    CERN Document Server

    Glasner, Ruth

    2009-01-01

    Ruth Glasner presents an illuminating reappraisal of Averroes' physics. Glasner is the first scholar to base her interpretation on the full range of Averroes' writings, including texts that are extant only in Hebrew manuscripts and have not been hitherto studied. She reveals that Averroes changed his interpretation of the basic notions of physics - the structure of corporeal reality and the definition of motion - more than once. After many hesitations he offers a bold newinterpretation of physics which Glasner calls 'Aristotelian atomism'. Ideas that are usually ascribed to scholastic scholars

  1. Turning Points: Improving Honors Student Preparation for Thesis Completion

    Science.gov (United States)

    Patino, Cynthia

    2012-01-01

    This dissertation is an action research study that had as its primary goal to increase retention of honors college students at Arizona State University by implementing an additional advising session during the fifth semester of their academic career. Introducing additional, strategically-timed support for the honors thesis and demystifying the…

  2. Butane/Propane. An economical and technical turning point

    International Nuclear Information System (INIS)

    Fridman, G.

    1998-01-01

    During 1997, the sales of all energies dropped. Even for the liquid fuel, its consumption came back under the level of three million tons. To fight this regression, liquid fuels producers innovate in the cisterns and the bottles and carry on their efforts in logistic matters. Hopes are allowed thanks to the new taxing and the demand increasing in the car industry, for liquid fuels. (A.L.B.)

  3. Adaptation Turning Points in River Restoration? The Rhine salmon case

    NARCIS (Netherlands)

    Bölscher, T.; Slobbe, van E.J.J.; Vliet, van M.T.H.; Werners, S.E.

    2013-01-01

    Abstract: Bringing a sustainable population of Atlantic salmon (Salmo salar) back into the Rhine, after the species became extinct in the 1950s, is an important environmental ambition with efforts made both by governments and civil society. Our analysis finds a significant risk of failure of salmon

  4. Thirteen and two fairy tales on the energy turning point

    International Nuclear Information System (INIS)

    Keil, Guenter

    2011-01-01

    Inspired by the choices and changes in the German energy policy, the author proposes controversial texts under the form of tales on the German policy and situation regarding energy. These tales ironically address the German energy model, the uselessness of the seven stopped nuclear power plants, the low cost of the energy turnaround made by the German government, the environmental benefit of renewable energies, the high potential of energy savings, the new means of electricity storage, the electric car as means to store electricity, the low cost of solar energy ('Sun does not send any bill'), the wind energy (the wind turbine fleet in such place can supply so much households), the geothermal energy, the so-called technological leap, the benefit of decentralized energy production, the numerous jobs created by renewable energies, the ecologic electric current, and the search for a final nuclear waste disposal site

  5. N. Chomsky am Wendepunkt (N. Chomsky at the Turning Point)?

    Science.gov (United States)

    Weisgerber, Leo

    1971-01-01

    Questions Chomsky's postulation of an innate capacity for language use, and suggests that Chomsky is modifying his theory by including the time factor in his consideration of language acquisition. (RS)

  6. A DAB Converter with Common-Point-Connected Winding Transformers Suitable for a Single-Phase 5-Level SST System

    Directory of Open Access Journals (Sweden)

    Hyeok-Jin Yun

    2018-04-01

    Full Text Available One of the main disadvantages of the multi-level solid-state transformer (SST system is the voltage imbalance on the output of the rectifier modules. This voltage imbalance can be caused by parameter mismatch of the active and passive components, different loads, and the floating structure of the high voltage DC-links. Some studies have been done to solve this voltage imbalance problem. A common way to avoid this imbalance is to balance the voltage of DC-links at the AC/DC conversion stage and balance the power between the modules at the DC/DC conversion stage. Most of these methods require a complex balancing controller or additional circuits. This paper proposes a novel dual active bridge (DAB converter specialized in power balancing in a single-phase 5-level SST system. The proposed DAB converter does not require any additional balancing controllers or techniques for power balancing. The performance of the proposed DAB converter was verified by simulation and experiments using a 3 kW 5-level SST prototype system.

  7. Sandstone Turning by Abrasive Waterjet

    Czech Academy of Sciences Publication Activity Database

    Hlaváček, Petr; Cárach, J.; Hloch, Sergej; Vasilko, K.; Klichová, Dagmar; Klich, Jiří; Lehocká, D.

    2015-01-01

    Roč. 48, č. 6 (2015), s. 2489-2493 ISSN 0723-2632 R&D Projects: GA MŠk ED2.1.00/03.0082; GA MŠk(CZ) LO1406 Institutional support: RVO:68145535 Keywords : turning away from the jet * conventional turning towards the jet * sandstone * abrasive water jet Subject RIV: JQ - Machines ; Tools Impact factor: 2.386, year: 2015 http://www.springerprofessional.de/sandstone-turning-by-abrasive-waterjet/6038028.html

  8. Sandstone Turning by Abrasive Waterjet

    Czech Academy of Sciences Publication Activity Database

    Hlaváček, Petr; Cárach, J.; Hloch, Sergej; Vasilko, K.; Klichová, Dagmar; Klich, Jiří; Lehocká, D.

    2015-01-01

    Roč. 48, č. 6 (2015), s. 2489-2493 ISSN 0723-2632 R&D Projects: GA MŠk ED2.1.00/03.0082; GA MŠk(CZ) LO1406 Institutional support: RVO:68145535 Keywords : turning away from the jet * conventional turning towards the jet * sandstone * abrasive water jet Subject RIV: JQ - Machines ; Tools Impact factor: 2.386, year: 2015 http://www.springerprofessional.de/sandstone-turning-by-abrasive- water jet/6038028.html

  9. Nutritional analysis of gastric contents and body condition score at a single time point in feral horses in Australia.

    Science.gov (United States)

    Hampson, Brian A; Owens, Elizabeth; Watts, Kathryn A; Mills, Paul C; Pollitt, Christopher C; de Laat, Melody A

    2011-09-01

    To determine the impact of a free-choice diet on nutritional intake and body condition of feral horses. Cadavers of 41 feral horses from 5 Australian locations. Body condition score (BCS) was determined (scale of 1 to 9), and the stomach was removed from horses during postmortem examination. Stomach contents were analyzed for nutritional variables and macroelement and microelement concentrations. Data were compared among the locations and also compared with recommended daily intakes for horses. Mean BCS varied by location; all horses were judged to be moderately thin. The BCS for males was 1 to 3 points higher than that of females. Amount of protein in the stomach contents varied from 4.3% to 14.9% and was significantly associated with BCS. Amounts of water-soluble carbohydrate and ethanol-soluble carbohydrate in stomach contents of feral horses from all 5 locations were higher than those expected for horses eating high-quality forage. Some macroelement and microelement concentrations were grossly excessive, whereas others were grossly deficient. There was no evidence of ill health among the horses. Results suggested that the diet for several populations of feral horses in Australia appeared less than optimal. However, neither low BCS nor trace mineral deficiency appeared to affect survival of the horses. Additional studies on food sources in these regions, including analysis of water-soluble carbohydrate, ethanol-soluble carbohydrate, and mineral concentrations, are warranted to determine the provenance of such rich sources of nutrients. Determination of the optimal diet for horses may need revision.

  10. A single point mutation within the coding sequence of cholera toxin B subunit will increase its expression yield.

    Science.gov (United States)

    Bakhshi, Bita; Boustanshenas, Mina; Ghorbani, Masoud

    2014-07-01

    Cholera toxin B subunit (CTB) has been extensively considered as an immunogenic and adjuvant protein, but its yield of expression is not satisfactory in many studies. The aim of this study was to compare the expression of native and mutant recombinant CTB (rCTB) in pQE vector. ctxB fragment from Vibrio cholerae O1 ATCC14035 containing the substitution of mutant ctxB for amino acid S128T was amplified by PCR and cloned in pGETM-T easy vector. It was then transformed to E. coli Top 10F' and cultured on LB agar plate containing ampicillin. Sequence analysis confirmed the mature ctxB gene sequence and the mutant one in both constructs which were further subcloned to pQE-30 vector. Both constructs were subsequently transformed to E. coli M15 (pREP4) for expression of mature and mutant rCTB. SDS-PAGE analysis showed the maximum expression of rCTB in both systems at 5 hours after induction and Western-blot analysis confirmed the presence of rCTB in blotting membranes. The expression of mutant rCTB was much higher than mature rCTB, which may be the result of serine-to-threonine substitution at position 128 of mature rCTB amino acid sequence created by PCR mutagenesis. The mutant rCTB retained pentameric stability and its ability to bind to anti- cholera toxin IgG antibodies. Point mutation in ctxB sequence resulted in over-expression of rCTB, probably due to the increase of solubility of produced rCTB. Consequently, this expression system can be used to produce rCTB in high yield.

  11. Single scan parameterization of space-variant point spread functions in image space via a printed array: the impact for two PET/CT scanners

    Energy Technology Data Exchange (ETDEWEB)

    Kotasidis, F A; Matthews, J C; Angelis, G I; Noonan, P J; Jackson, A [Imaging, Genomics and Proteomics, Wolfson Molecular Imaging Centre, MAHSC, University of Manchester, Manchester (United Kingdom); Price, P [Academic Department of Radiation Oncology, University of Manchester, Manchester (United Kingdom); Lionheart, W R [School of Mathematics, Alan Turing Building, University of Manchester, Manchester (United Kingdom); Reader, A J, E-mail: fotis.kotasidis@mmic.man.ac.uk [Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC (Canada)

    2011-05-21

    Incorporation of a resolution model during statistical image reconstruction often produces images of improved resolution and signal-to-noise ratio. A novel and practical methodology to rapidly and accurately determine the overall emission and detection blurring component of the system matrix using a printed point source array within a custom-made Perspex phantom is presented. The array was scanned at different positions and orientations within the field of view (FOV) to examine the feasibility of extrapolating the measured point source blurring to other locations in the FOV and the robustness of measurements from a single point source array scan. We measured the spatially-variant image-based blurring on two PET/CT scanners, the B-Hi-Rez and the TruePoint TrueV. These measured spatially-variant kernels and the spatially-invariant kernel at the FOV centre were then incorporated within an ordinary Poisson ordered subset expectation maximization (OP-OSEM) algorithm and compared to the manufacturer's implementation using projection space resolution modelling (RM). Comparisons were based on a point source array, the NEMA IEC image quality phantom, the Cologne resolution phantom and two clinical studies (carbon-11 labelled anti-sense oligonucleotide [{sup 11}C]-ASO and fluorine-18 labelled fluoro-l-thymidine [{sup 18}F]-FLT). Robust and accurate measurements of spatially-variant image blurring were successfully obtained from a single scan. Spatially-variant resolution modelling resulted in notable resolution improvements away from the centre of the FOV. Comparison between spatially-variant image-space methods and the projection-space approach (the first such report, using a range of studies) demonstrated very similar performance with our image-based implementation producing slightly better contrast recovery (CR) for the same level of image roughness (IR). These results demonstrate that image-based resolution modelling within reconstruction is a valid alternative to

  12. In-vivo visualisation of the anatomical structures related to the acupuncture points Dai mai and Shen mai by MRI: A single-case pilot study

    International Nuclear Information System (INIS)

    Moncayo, Roy; Rudisch, Ansgar; Diemling, Markus; Kremser, Christian

    2007-01-01

    The concept of acupuncture point localisation in Traditional Chinese Medicine (TCM) is based on millenary practical experience. Modern imaging methods such as PET, MRI and SPECT have been used primary for the investigation of the mechanisms of action of acupuncture. In this pilot single-case study we have evaluated the technical possibilities for in-vivo imaging of the anatomical relations of acupuncture points using state of the art MRI. Preliminary experiments relating to the quality of acupuncture needles under the setting of MRI were done both with stainless steel and gold needles. In a second step, in-vivo imaging was carried out. A licensed acupuncture practitioner (RM) chose two points belonging to the so-called extraordinary vessels. In 2 sequential, separate procedures, he inserted himself gold acupuncture needles using a neutral technique (known as Ping Bu Ping Xie) into the Dai mai and Shen mai points, i.e. gall bladder 26 and bladder 62. Imaging was done on a Siemens Magnetom Avanto MR scanner using a head array and body coil. Mainly T1-weighted imaging sequences, as routinely used for patient exams, were used to obtain multi-slice images. In the preliminary experiments only acupuncture needles made of gold showed enough stability in order to be used for further imaging procedures. Using an onion and a banana as an object, further studies showed that the gold needles produced a void defect that corresponds to the tip of the inserted needle, while at the same time an artefactually increased diameter was observed. The in-vivo experiments showed that the Dai mai point was in relation to the abdominal internal oblique muscle. The Shen mai point artefact showed up close to the longus and brevis peroneal tendons at the fibular malleolus. Side effects related to heating or burning were not observed. Improved anatomical recognition was obtained using 3D-volume rendering techniques. Through an adequate choice of acupuncture material (gold needles) as well as of

  13. Turning patients over in bed

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000426.htm Turning patients over in bed To use the sharing features on this page, ... Patient The following steps should be followed when turning a patient: If you can, raise the bed to a level that reduces back strain for ...

  14. Turn-Continuation by Self and by Other

    Science.gov (United States)

    Sidnell, Jack

    2012-01-01

    At the possible completion of a turn constructional unit (TCU) that has not selected a next speaker, a speaker has two available options: either begin a new TCU or continue the one that has just come to a point of possible completion. This article describes some of the complex turns that result from exercising the second option. These can be seen…

  15. Glutamate Excitotoxicity Is Involved in the Induction of Paralysis in Mice after Infection by a Human Coronavirus with a Single Point Mutation in Its Spike Protein▿

    Science.gov (United States)

    Brison, Elodie; Jacomy, Hélène; Desforges, Marc; Talbot, Pierre J.

    2011-01-01

    Human coronaviruses (HCoV) are recognized respiratory pathogens, and some strains, including HCoV-OC43, can infect human neuronal and glial cells of the central nervous system (CNS) and activate neuroinflammatory mechanisms. Moreover, HCoV-OC43 is neuroinvasive, neurotropic, and neurovirulent in susceptible mice, where it induces chronic encephalitis. Herein, we show that a single point mutation in the viral spike (S) glycoprotein (Y241H), acquired during viral persistence in human neural cells, led to a hind-limb paralytic disease in infected mice. Inhibition of glutamate excitotoxicity using a 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propranoic acid (AMPA) receptor antagonist (GYKI-52466) improved clinical scores related to the paralysis and motor disabilities in S mutant virus-infected mice, as well as protected the CNS from neuronal dysfunctions, as illustrated by restoration of the phosphorylation state of neurofilaments. Expression of the glial glutamate transporter GLT-1, responsible for glutamate homeostasis, was downregulated following infection, and GYKI-52466 also significantly restored its steady-state expression level. Finally, GYKI-52466 treatment of S mutant virus-infected mice led to reduced microglial activation, which may lead to improvement in the regulation of CNS glutamate homeostasis. Taken together, our results strongly suggest an involvement of excitotoxicity in the paralysis-associated neuropathology induced by an HCoV-OC43 mutant which harbors a single point mutation in its spike protein that is acquired upon persistent virus infection. PMID:21957311

  16. A single point mutation in Tomato spotted wilt virus NSs protein is sufficient to overcome Tsw-gene-mediated resistance in pepper.

    Science.gov (United States)

    Almási, Asztéria; Nemes, Katalin; Csömör, Zsófia; Tóbiás, István; Palkovics, László; Salánki, Katalin

    2017-06-01

    The nonstructural protein (NSs) of Tomato spotted wilt virus (TSWV) was previously identified as an avirulence determinant for Tsw-based resistance on pepper. The NSs of wild-type (WT) and resistance-breaking (RB) TSWV strains isolated in Hungary had only two amino acid substitutions (104, 461). We have analysed the ability of the NSs and their point mutant variants to trigger Tsw-mediated hypersensitive responses and RNA silencing suppressor (RSS) activity in patch assays. We identified a single amino acid change at position 104 (T-A) that was responsible for the necrosis induction or loss, while a significant difference was not detected in the RSS activity of the two parental strains. We have successfully complemented the infection of the WT strain on resistant pepper cultivar with the infectious S RNA transcript of the RB strain and the WT-T104A point mutant. Our work provides direct evidence that a single amino acid change can induce an RB phenotype.

  17. A national assessment of underground natural gas storage: identifying wells with designs likely vulnerable to a single-point-of-failure

    Science.gov (United States)

    Michanowicz, Drew R.; Buonocore, Jonathan J.; Rowland, Sebastian T.; Konschnik, Katherine E.; Goho, Shaun A.; Bernstein, Aaron S.

    2017-05-01

    The leak of processed natural gas (PNG) from October 2015 to February 2016 from the Aliso Canyon storage facility, near Los Angeles, California, was the largest single accidental release of greenhouse gases in US history. The Interagency Task Force on Natural Gas Storage Safety and California regulators recently recommended operators phase out single-point-of-failure (SPF) well designs. Here, we develop a national dataset of UGS well activity in the continental US to assess regulatory data availability and uncertainty, and to assess the prevalence of certain well design deficiencies including single-point-of-failure designs. We identified 14 138 active UGS wells associated with 317 active UGS facilities in 29 states using regulatory and company data. State-level wellbore datasets contained numerous reporting inconsistencies that limited data concatenation. We identified 2715 active UGS wells across 160 facilities that, like the failed well at Aliso Canyon, predated the storage facility, and therefore were not originally designed for gas storage. The majority (88%) of these repurposed wells are located in OH, MI, PA, NY, and WV. Repurposed wells have a median age of 74 years, and the 2694 repurposed wells constructed prior to 1979 are particularly likely to exhibit design-related deficiencies. An estimated 210 active repurposed wells were constructed before 1917—before cement zonal isolation methods were utilized. These wells are located in OH, PA, NY, and WV and represent the highest priority related to potential design deficiencies that could lead to containment loss. This national baseline assessment identifies regulatory data uncertainties, highlights a potentially widespread vulnerability of the natural gas supply chain, and can aid in prioritization and oversight for high-risk wells and facilities.

  18. Turning collectors for solar radiation

    Science.gov (United States)

    Barak, Amitzur Z.

    1976-01-01

    A device is provided for turning a solar collector about the polar axis so that the collector is directed toward the sun as the sun tracks the sky each day. It includes two heat-expansive elements and a shadow plate. In the morning a first expansive element is heated, expands to turn the collector to face the sun, while the second expansive element is shaded by the plate. In the afternoon the second element is heated, expands to turn the collector to face the sun, while the first is shaded by the plate.

  19. Train turn restrictions and line plan performance

    DEFF Research Database (Denmark)

    Burggraeve, Sofie; Bull, Simon Henry; Lusby, Richard Martin

    In this paper we study the impact of the `turn conditions' in end stations on the performance of a line plan. If trains have to turn on their platform in an end station, the yoccupy the platform for several minutes. A more preferred option, from a timetabling point of view, would be that a train...... disappears from the platform in its end station after dwelling and only appears again when departing for a subsequent trip. In this case, the train will not interfere with other trains that dwell on the platform during the time between these events. However, this option is only possible if the train can stay...... in a exible and large enough shunt. Starting from a given line plan, we compare two timetables, one where trains have to turn on their platform and one where trains can turn in a shunt. We evaluate the impact on the performance of the line plan by its feasibility for timetabling,the minimum overall buffer...

  20. CONNECTION OF TURN AHEAD AND TURN BACK WITH MOTORIC ABILITIES OF THE FOURTH GRADE OF HIGH SCHOOL

    Directory of Open Access Journals (Sweden)

    Jovica Petković

    2008-08-01

    Full Text Available The research is done for the purpose of determination and defining of the level of connection between some motoric abilities with success in realization of programmed contents from the area of gymnastics (turn ahead and turn back. The research is done on the sample of fifty students from the fourth grade of High School, on ten motoric tests and on two specific motoric assignments – turn ahead and turn back. The results of this research clearly point that there exist the multitude of statistically important coefficients of correlation between treated motoric abilities and applied motoric assignments.

  1. A study on density functional theory of the effect of pressure on the formation and migration enthalpies of intrinsic point defects in growing single crystal Si

    Science.gov (United States)

    Sueoka, Koji; Kamiyama, Eiji; Kariyazaki, Hiroaki

    2012-05-01

    In 1982, Voronkov presented a model describing point defect behavior during the growth of single crystal Si from a melt and derived an expression to predict if the crystal was vacancy- or self-interstitial-rich. Recently, Vanhellemont claimed that one should take into account the impact of compressive stress introduced by the thermal gradient at the melt/solid interface by considering the hydrostatic pressure dependence of the formation enthalpy of the intrinsic point defects. To evaluate the impact of thermal stress more correctly, the pressure dependence of both the formation enthalpy (Hf) and the migration enthalpy (Hm) of the intrinsic point defects should be taken into account. Furthermore, growing single crystal Si is not under hydrostatic pressure but almost free of external pressure (generally in Ar gas under reduced pressure). In the present paper, the dependence of Hf and Hm on the pressure P, or in other words, the pressure dependence of the formation energy (Ef) and the relaxation volume (vf), is quantified by density functional theory calculations. Although a large number of ab initio calculations of the properties of intrinsic point defects have been published during the last years, calculations for Si crystals under pressure are rather scarce. For vacancies V, the reported pressure dependences of HfV are inconsistent. In the present study, by using 216-atom supercells with a sufficient cut-off energy and mesh of k-points, the neutral I and V are found to have nearly constant formation energies EfI and EfV for pressures up to 1 GPa. For the relaxation volume, vfI is almost constant while vfV decreases linearly with increasing pressure P. In case of the hydrostatic pressure Ph, the calculated formation enthalpy HfI and migration enthalpy HmI at the [110] dumbbell site are given by HfI = 3.425 - 0.057 × Ph (eV) and HmI = 0.981 - 0.039 × Ph (eV), respectively, with Ph given in GPa. The calculated HfV and HmV dependencies on Ph given by HfV = 3.543 - 0

  2. What 'empirical turn in bioethics'?

    Science.gov (United States)

    Hurst, Samia

    2010-10-01

    Uncertainty as to how we should articulate empirical data and normative reasoning seems to underlie most difficulties regarding the 'empirical turn' in bioethics. This article examines three different ways in which we could understand 'empirical turn'. Using real facts in normative reasoning is trivial and would not represent a 'turn'. Becoming an empirical discipline through a shift to the social and neurosciences would be a turn away from normative thinking, which we should not take. Conducting empirical research to inform normative reasoning is the usual meaning given to the term 'empirical turn'. In this sense, however, the turn is incomplete. Bioethics has imported methodological tools from empirical disciplines, but too often it has not imported the standards to which researchers in these disciplines are held. Integrating empirical and normative approaches also represents true added difficulties. Addressing these issues from the standpoint of debates on the fact-value distinction can cloud very real methodological concerns by displacing the debate to a level of abstraction where they need not be apparent. Ideally, empirical research in bioethics should meet standards for empirical and normative validity similar to those used in the source disciplines for these methods, and articulate these aspects clearly and appropriately. More modestly, criteria to ensure that none of these standards are completely left aside would improve the quality of empirical bioethics research and partly clear the air of critiques addressing its theoretical justification, when its rigour in the particularly difficult context of interdisciplinarity is what should be at stake.

  3. An experimental investigation on dynamics and heat transfer associated with a single droplet impacting on a hot surface above the Leidenfrost point temperature

    Energy Technology Data Exchange (ETDEWEB)

    Park, J.; Kim, H. [Kyung Hee Univ., Gyeonggi-do (Korea, Republic of). Dept. of Nuclear Engineering

    2016-07-15

    During large loss-of-coolant accidents in nuclear reactors, water splatters as the quench front propagates at the quenching surface, and many droplets of different sizes and velocities are generated and carried with the steam in the cooling channel. Heat transfer due to droplets striking an overheated fuel rod above the Leidenfrost point temperature is important for predicting the peak cladding temperature. This study investigated the dynamics and heat transfer characteristics when a single droplet at room temperature collided with a surface at 425 C experimentally, using synchronized high-speed video and infrared cameras. Various physical parameters related to heat transfer model development were measured, including the residence time, spreading diameter, local heat flux distribution, effective heat transfer area, average vapor film thickness, and total heat transfer per collision. The measured data were compared with the values of the physical parameters predicted by existing mechanistic models.

  4. A Generic Simulation Approach for the Fast and Accurate Estimation of the Outage Probability of Single Hop and Multihop FSO Links Subject to Generalized Pointing Errors

    KAUST Repository

    Ben Issaid, Chaouki

    2017-07-28

    When assessing the performance of the free space optical (FSO) communication systems, the outage probability encountered is generally very small, and thereby the use of nave Monte Carlo simulations becomes prohibitively expensive. To estimate these rare event probabilities, we propose in this work an importance sampling approach which is based on the exponential twisting technique to offer fast and accurate results. In fact, we consider a variety of turbulence regimes, and we investigate the outage probability of FSO communication systems, under a generalized pointing error model based on the Beckmann distribution, for both single and multihop scenarios. Selected numerical simulations are presented to show the accuracy and the efficiency of our approach compared to naive Monte Carlo.

  5. Introduction of a point mutation into an HLA class I single-chain trimer induces enhancement of CTL priming and antitumor immunity

    Directory of Open Access Journals (Sweden)

    Masanori Matsui

    2014-01-01

    Full Text Available We previously discovered one particular HLA-A*02:01 mutant that enhanced peptide-specific cytotoxic T lymphocyte (CTL recognition in vitro compared to wild-type HLA-A*02:01. This mutant contains a single amino acid substitution from histidine to leucine at position 74 (H74L that is located in the peptide-binding groove. To investigate the effect of the H74L mutation on the in vivo CTL priming, we took advantage of the technology of the HLA class I single-chain trimer (SCT in which three components involving a peptide, β2 microglobulin and the HLA class I heavy chain are joined together via flexible linkers. We generated recombinant adenovirus expressing SCT comprised influenza A matrix protein (FMP-derived peptide, β2 microglobulin and the H74L heavy chain. HLA-A*02:01 transgenic mice were immunized with the adenovirus, and the induction of peptide-specific CTLs and antitumor immunity was investigated. It was clearly shown that the H74L mutation enabled the HLA-A*02:01 SCT molecule to dramatically enhance both in vivo priming of FMP-specific CTLs and protection against a lethal challenge of tumor cells expressing FMP. These data present the first evidence that a simple point mutation in the HLA class I heavy chain of SCT is beneficial for improving CTL-based immunotherapy and prophylaxis to control tumors.

  6. Comparison of a multi-breath-hold and a single breath-hold cine imaging approach for 4D guide-point modeling of the left ventricle

    International Nuclear Information System (INIS)

    Heilmaier, C.; Schlosser, T.; Nassenstein, K.; Bruder, O.

    2010-01-01

    Purpose: Guide-point modeling (GPM) enables reliable and time-efficient assessment of left ventricular (LV) volumes when using sequences that allow acquisition of short- and long-axis scans within a single breath-hold. Slice misalignment may influence GPM analysis of standard multi-breath-hold images due to image acquisition in different breath-holds. Thus, our study aimed to assess if such an approach allows for reliable volumetric calculations in the clinical routine. Materials and Methods: 52 patients were examined on a 1.5 T scanner with multi-breath-hold acquisitions on the standard short- and long-axis using an SSFP (TR 3 ms, TE 1.5 ms, FA 60 ) sequence and a TPAT accelerated SSFP (TR 4.6 msec, TE 1.1msec, FA 60 , acceleration factor 3) sequence that covered the LV in 3 short- and 2 long-axis slices within a single breath-hold. For both datasets GPM was used to assess LV volumes. In addition, LV parameters were calculated by applying the summation of slices (SoS) approach (standard of reference) with the short-axis views of the multi-breath-hold dataset. Results: The post-processing times were shorter with both GPM approaches (both, p 0.97). Conclusion: Cine short- and long-axis images that had been acquired in different breath-holds can be reliably evaluated by the GPM approach. (orig.)

  7. Visit of Peters Higgs at Point 2 ALICE Experiment - British theoretical physicist, He worked on proposals to unify the weak and the electromagnetic forces into a single electroweak theory, The Boson of Higgs.

    CERN Multimedia

    Mona Schweizer

    2008-01-01

    Visit of Peters Higgs at Point 2 ALICE Experiment - British theoretical physicist, He worked on proposals to unify the weak and the electromagnetic forces into a single electroweak theory, The Boson of Higgs.

  8. Turning rice meiosis into mitosis.

    Science.gov (United States)

    Mieulet, Delphine; Jolivet, Sylvie; Rivard, Maud; Cromer, Laurence; Vernet, Aurore; Mayonove, Pauline; Pereira, Lucie; Droc, Gaëtan; Courtois, Brigitte; Guiderdoni, Emmanuel; Mercier, Raphael

    2016-11-01

    Introduction of clonal reproduction through seeds (apomixis) in crops has the potential to revolutionize agriculture by allowing self-propagation of any elite variety, in particular F1 hybrids. In the sexual model plant Arabidopsis thaliana synthetic clonal reproduction through seeds can be artificially implemented by (i) combining three mutations to turn meiosis into mitosis (MiMe) and (ii) crossing the obtained clonal gametes with a line expressing modified CENH3 and whose genome is eliminated in the zygote. Here we show that additional combinations of mutations can turn Arabidopsis meiosis into mitosis and that a combination of three mutations in rice (Oryza sativa) efficiently turns meiosis into mitosis, leading to the production of male and female clonal diploid gametes in this major crop. Successful implementation of the MiMe technology in the phylogenetically distant eudicot Arabidopsis and monocot rice opens doors for its application to any flowering plant and paves the way for introducing apomixis in crop species.

  9. Optimum transfer between hyperbolic asymptotes with turn angle less than the maximum natural turn angle.

    Science.gov (United States)

    Walton, J. M.; Marchal, C.; Culp, R. D.

    1971-01-01

    The impulsive transfer of minimum characteristic velocity between two given hyperbolic asymptotes associated with a real planet is considered. The constraint of remaining above the surface of the planet introduces a maximum natural turn angle. This divides the problem naively into two categories. The first is the case when the turn angle required by the given asymptotes is less than or equal to the maximum natural turn angle. This is the more reasonable situation for a swingby maneuver, and is the case considered in this paper. The resulting optimal transfers are of five basic types. In boundary conditions space, by far the largest area of transfers are either single impulse transfers or transfers through the parabolic level requiring two finite impulses. In no case has an optimal transfer been found which uses more than two finite impulses and three infinitesimal impulses. Complete results are presented for the case in which the given turn angle is less than or equal to the maximum natural turn angle.

  10. Turning a page of Agency history

    International Nuclear Information System (INIS)

    1969-01-01

    Recent developments, and especially the new and critical interest of developing countries, have helped to mark the turning of a page in the Agency's history. If the present situation in the economics of nuclear power does not change there is a danger that developing countries will lag further and further behind the advanced countries in its use. Shortage of resources impose a brake on Agency efforts to promote benefits of nuclear techniques, especially by technical assistance. These were some of the points made by Dr. Sigvard Eklund, the Director General, when he presented the Agency's annual report to the Economic and Social Council (ECOSOC) in July. (author)

  11. Os pontos de virada na formação do professor universitário: um estudo sobre o mecanismo da identificação The "turning points" in the formation of the university teacher: a study of the mechanism of identification

    Directory of Open Access Journals (Sweden)

    Claudia Rosa Riolfi

    2007-08-01

    Full Text Available O presente artigo tem como objeto a formação do professor universitário. Volta-se para a elucidação das seguintes questões: a os avanços para a compreensão da natureza do percurso a ser trilhado para que se instale, no professor universitário em formação, um desejo que encontre seu norte no ato de ensinar que são possíveis de se levar em consideração, ao tomar em consideração a psicanálise lacaniana; e b a configuração dos pontos de virada por meio dos quais um sujeito em formação vem a construir um lugar singular de onde possa criar um trabalho próprio de professor universitário. Postula a necessidade do ultrapassamento do que estamos chamando de pontos de virada para que aquele que está em um percurso de formação, para se tornar professor universitário, possa vir a criar um espaço próprio para o exercício da docência, fundando, portanto, a possibilidade da re-invenção de um si próprio. Para tal fim, estamos recorrendo ao conceito de identificação - tal qual é visto na psicanálise de orientação lacaniana - para elucidar a experiência decorrida no âmbito do Programa de Aperfeiçoamento de Ensino (PAE, ao longo de 2005, em duas disciplinas (cujos alunos são prioritariamente oriundos da graduação em Lingüística da Faculdade de Filosofia, Letras e Ciências Humanas da USP, que têm a carga horária de 120 horas cada uma (60 em sala de aula e 60 de estágio supervisionado.This article takes as its object the formation of the university teacher, turning its attention to the elucidation of the following issues: a the developments in the understanding of the nature of the path to be followed so as to instill in the university teacher under formation a will oriented towards the act of teaching, developments that can be assessed from the perspective of Lacanian psychoanalysis; and b the configuration of "turning points" after which a subject under formation builds a singular place where it is possible to

  12. Professional Employees Turn to Unions

    Science.gov (United States)

    Chamot, Dennis

    1976-01-01

    White-collar and professional employees are increasingly turning to unions to combat their loss of independence as employees of large organizations. Managers should realize that they and professional employees have different viewpoints about job situations and that the current trend toward white-collar unionism is apt to continue. (JG)

  13. Hamilton's theory of turns revisited

    Indian Academy of Sciences (India)

    We present a new approach to Hamilton's theory of turns for the groups. SO(3) and SU(2) which renders their properties, in particular their composition law, nearly trivial and immediately evident upon inspection. We show that the entire con- struction can be based on binary rotations rather than mirror reflections. Keywords.

  14. Why Does Hair Turn Gray?

    Science.gov (United States)

    ... out, but people with naturally lighter hair are just as likely to go gray. From the time a person notices a few gray hairs, it may take more than 10 years for all of that person's hair to turn ... really believe that this happens. Just in case, try not to freak out your ...

  15. Phenomenology and the Empirical Turn

    NARCIS (Netherlands)

    Zwier, Jochem; Blok, Vincent; Lemmens, Pieter

    2016-01-01

    This paper provides a phenomenological analysis of postphenomenological philosophy of technology. While acknowledging that the results of its analyses are to be recognized as original, insightful, and valuable, we will argue that in its execution of the empirical turn, postphenomenology forfeits

  16. Hamilton's theory of turns revisited

    Indian Academy of Sciences (India)

    MS received 16 July 2009; accepted 1 September 2009. Abstract. We present a new approach to Hamilton's theory of turns for the groups. SO(3) and SU(2) which renders their properties, in particular their composition law, nearly trivial and immediately evident upon inspection. We show that the entire con- struction can be ...

  17. APPLIANCE OF COMPETITORS TECHNIQUES IN LEADING THE SKIES IN TURNING

    Directory of Open Access Journals (Sweden)

    Rašid Hadžić

    2009-11-01

    Full Text Available Competitors techniques in skiing characterize driving on edges, without gliding in certain fazes of turning. Today that characteristic is more and more present in all di- scipline, (downhill, super G, giant slalom and slalom so we can talk about appliance of basic technique of leading skies on all disciplines, with differences in position of skies in amplitude of moving and frequencies of changes of edges. From that point of view we distinct three typical shape of moving in turning, which have mutual distinction in influence on ski loading, and that has influence on tur- ning line and acceleration or checking in certain fazes of turning.

  18. Opposed turns at signalized intersections

    Energy Technology Data Exchange (ETDEWEB)

    Akcelik, R.

    1989-06-01

    The 1985 Highway Capacity Manual (HCM) brought the U.S. and Australian methodologies for signalized intersections closer together. An important element in this methodology is the techniques used for the estimation of opposed (permissive) turn saturation flows. Although the basic modeling philosophies of the HCM and Australian methods are similar, there are significant differences in the procedures used and therefore in the results from the two methods. In particular, the latest methodology employed in the SIDRA software has eliminated the use of opposed turn adjustment factors for lane groups and adopted an explicit and direct method of modeling individual lanes. The purpose of this paper is to bring these new methods to the attention of the U.S. researchers since it is understood that efforts are being made to improve the 1985 HCM method.

  19. Diamond turning machine controller implementation

    Energy Technology Data Exchange (ETDEWEB)

    Garrard, K.P.; Taylor, L.W.; Knight, B.F.; Fornaro, R.J.

    1988-12-01

    The standard controller for a Pnuemo ASG 2500 Diamond Turning Machine, an Allen Bradley 8200, has been replaced with a custom high-performance design. This controller consists of four major components. Axis position feedback information is provided by a Zygo Axiom 2/20 laser interferometer with 0.1 micro-inch resolution. Hardware interface logic couples the computers digital and analog I/O channels to the diamond turning machine`s analog motor controllers, the laser interferometer, and other machine status and control information. It also provides front panel switches for operator override of the computer controller and implement the emergency stop sequence. The remaining two components, the control computer hardware and software, are discussed in detail below.

  20. Turn-by-Turn Imaging of the Transverse Beam Profile in PEP-II

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, Alan A.; Petree, Mark; /SLAC

    2006-12-18

    During injection or instability, the transverse profile of an individual bunch in a storage ring can change significantly in a few turns. However, most synchrotron-light imaging techniques are not designed for this time scale. We have developed a novel diagnostic that enhances the utility of a fast gated camera by adding, inexpensively, some features of a dual-axis streak camera, in order to watch the turn-by-turn evolution of the transverse profile, in both x and y. The beam's elliptical profile is reshaped using cylindrical lenses to form a tall and narrow ellipse--essentially the projection of the full ellipse onto one transverse axis. We do this projection twice, by splitting the beam into two paths at different heights, and rotating the ellipse by 90{sup o} on one path. A rapidly rotating mirror scans these vertical ''pencils'' of light horizontally across the photocathode of the camera, which is gated for 3 ns on every Nth ring turn. A single readout of the camera captures 100 images, looking like a stroboscopic photograph of a moving object. We have observed the capture of injected charge into a bunch and the rapid change of beam size at the onset of a fast instability.

  1. Relative effectiveness of kinetic analysis vs single point readings for classifying environmental samples based on community-level physiological profiles (CLPP)

    Science.gov (United States)

    Garland, J. L.; Mills, A. L.; Young, J. S.

    2001-01-01

    The relative effectiveness of average-well-color-development-normalized single-point absorbance readings (AWCD) vs the kinetic parameters mu(m), lambda, A, and integral (AREA) of the modified Gompertz equation fit to the color development curve resulting from reduction of a redox sensitive dye from microbial respiration of 95 separate sole carbon sources in microplate wells was compared for a dilution series of rhizosphere samples from hydroponically grown wheat and potato ranging in inoculum densities of 1 x 10(4)-4 x 10(6) cells ml-1. Patterns generated with each parameter were analyzed using principal component analysis (PCA) and discriminant function analysis (DFA) to test relative resolving power. Samples of equivalent cell density (undiluted samples) were correctly classified by rhizosphere type for all parameters based on DFA analysis of the first five PC scores. Analysis of undiluted and 1:4 diluted samples resulted in misclassification of at least two of the wheat samples for all parameters except the AWCD normalized (0.50 abs. units) data, and analysis of undiluted, 1:4, and 1:16 diluted samples resulted in misclassification for all parameter types. Ordination of samples along the first principal component (PC) was correlated to inoculum density in analyses performed on all of the kinetic parameters, but no such influence was seen for AWCD-derived results. The carbon sources responsible for classification differed among the variable types with the exception of AREA and A, which were strongly correlated. These results indicate that the use of kinetic parameters for pattern analysis in CLPP may provide some additional information, but only if the influence of inoculum density is carefully considered. c2001 Elsevier Science Ltd. All rights reserved.

  2. Point-of-Care Determination of Acetaminophen Levels with Multi-Hydrogen Bond Manipulated Single-Molecule Recognition (eMuHSiR).

    Science.gov (United States)

    Zhang, Yan; Huang, Zhongyuan; Wang, Letao; Wang, Chunming; Zhang, Changde; Wiese, Tomas; Wang, Guangdi; Riley, Kevin; Wang, Zhe

    2018-04-03

    This work aims to face the challenge of monitoring small molecule drugs accurately and rapidly for point-of-care (POC) diagnosis in current clinical settings. Overdose of acetaminophen (AP), a commonly used over the counter (OTC) analgesic drug, has been determined to be a major cause of acute liver failure in the US and the UK. However, there is no rapid and accurate detection method available for this drug in the emergency room. The present study examined an AP sensing strategy that relies on a previously unexplored strong interaction between AP and the arginine (Arg) molecule. It was found that as many as 4 hydrogen bonds can be formed between one Arg molecule and one AP molecule. By taking advantages of this structural selectivity and high tenability of hydrogen bonds, Arg, immobilized on a graphene surface via electrostatic interactions, was utilized to structurally capture AP. Interestingly, bonded AP still remained the perfect electrochemical activities. The extent of Arg-AP bonds was quantified using a newly designed electrochemical (EC) sensor. To verify the feasibility of this novel assay, based on multihydrogen bond manipulated single-molecule recognition (eMuHSiR), both pharmaceutical and serum sample were examined. In commercial tablet measurement, no significant difference was seen between the results of eMuHSiR and other standard methods. For measuring AP concentration in the mice blood, the substances in serum, such as sugars and fats, would not bring any interference to the eMuHSiR in a wide concentration range. This eMuHSiR method opens the way for future development of small molecule detection for the POC testing.

  3. Recommendations for collaborative paediatric research including biobanking in Europe: a Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) initiative.

    Science.gov (United States)

    Kuemmerle-Deschner, Jasmin B; Hansmann, Sandra; Wulffraat, Nico M; Vastert, Sebastiaan J; Hens, Kristien; Anton, Jordi; Avcin, Tadej; Martini, Alberto; Koné-Paut, Isabelle; Uziel, Yosef; Ravelli, Angelo; Wouters, Carine; Shaw, David; Özen, Seza; Eikelberg, Andreas; Prakken, Berent J; Ruperto, Nicolino; Horneff, Gerd; Constantin, Tamas; Beresford, Michael W; Sikken, Marijn; Foster, Helen E; Haug, Iris; Schuller, Sabrina; Jägle, Christine; Benseler, Susanne M

    2018-03-01

    Innovative research in childhood rheumatic diseases mandates international collaborations. However, researchers struggle with significant regulatory heterogeneity; an enabling European Union (EU)-wide framework is missing. The aims of the study were to systematically review the evidence for best practice and to establish recommendations for collaborative research. The Paediatric Rheumatology European Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) project enabled a scoping review and expert discussion, which then informed the systematic literature review. Published evidence was synthesised; recommendations were drafted. An iterative review process and consultations with Ethics Committees and European experts for ethical and legal aspects of paediatric research refined the recommendations. SHARE experts and patient representatives vetted the proposed recommendations at a consensus meeting using Nominal Group Technique. Agreement of 80% was mandatory for inclusion. The systematic literature review returned 1319 records. A total of 223 full-text publications plus 22 international normative documents were reviewed; 85 publications and 16 normative documents were included. A total of 21 recommendations were established including general principles (1-3), ethics (4-7), paediatric principles (8 and 9), consent to paediatric research (10-14), paediatric databank and biobank (15 and 16), sharing of data and samples (17-19), and commercialisation and third parties (20 and 21). The refined recommendations resulted in an agreement of >80% for all recommendations. The SHARE initiative established the first recommendations for Paediatric Rheumatology collaborative research across borders in Europe. These provide strong support for an urgently needed European framework and evidence-based guidance for its implementation. Such changes will promote research in children with rheumatic diseases. © Article author(s) (or their employer(s) unless otherwise

  4. Sharp Turning and Corner Turning: Comparison of Energy Expenditure, Gait Parameters, and Level of Fatigue among Community-Dwelling Elderly

    Directory of Open Access Journals (Sweden)

    Maria Justine

    2014-01-01

    Full Text Available This study compares energy expenditure (EE, gait parameters (GP, and level of fatigue (LOF between 5-minute walking with sharp turning (ST and corner turning (CT. Data were obtained from 29 community-dwelling elderly (mean age, 62.7 ± 3.54 years. For 5 minutes, in ST task, participants walked on a 3-meter pathway with 2 cones placed at each end (180° turning, while in CT task, participants walked on a 6-meter pathway with 4 cones placed at 4 corners (90° turning. The physiological cost index, pedometer, and 10-point Modified Borg Dyspnoea Scale were used to measure EE (beats/min, GP (no of steps, and LOF, respectively. Data were analyzed by using independent t-tests. EE during ST (0.62 ± 0.21 beats/min was significantly higher than CT (0.48 ± 0.17 beats/min (P0.05. Higher EE in ST could be due to the difficulty in changing to a 180° direction, which may involve agility and different turning strategies (step-turn or pivot-turn to adjust the posture carefully. In CT, participants could choose a step-turn strategy to change to a 90° direction, which was less challenging to postural control.

  5. Model-independent analysis of the Fermilab Tevatron turn-by-turn beam position monitor measurements

    Energy Technology Data Exchange (ETDEWEB)

    Petrenko, A.V.; /Novosibirsk, IYF; Valishev, A.A.; Lebedev, V.A.; /Fermilab

    2011-09-01

    Coherent transverse beam oscillations in the Tevatron were analyzed with the model-independent analysis (MIA) technique. This allowed one to obtain the model-independent values of coupled betatron amplitudes, phase advances, and dispersion function around the ring from a single dipole kick measurement. In order to solve the MIA mode mixing problem which limits the accuracy of determination of the optical functions, we have developed a new technique of rotational MIA mode untangling. The basic idea is to treat each beam position monitor (BPM) as two BPMs separated in a ring by exactly one turn. This leads to a simple criterion of MIA mode separation: the betatron phase advance between any BPM and its counterpart shifted by one turn should be equal to the betatron tune and therefore should not depend on the BPM position in the ring. Furthermore, we describe a MIA-based technique to locate vibrating magnets in a storage ring.

  6. mTransport: Two-point-correlation function calculator

    Science.gov (United States)

    Dias, Mafalda; Frazer, Jonathan; Seery, David

    2017-10-01

    mTransport computes the 2-point-correlation function of the curvature and tensor perturbations in multifield models of inflation in the presence of a curved field space. It is a Mathematica implementation of the transport method which encompasses scenarios with violations of slow-roll conditions and turns of the trajectory in field space. It can be used for an arbitrary mass spectrum, including massive modes, particle production and models with quasi-single-field dynamics.

  7. MEDIACRACY TURNS INTO A SYNONYM OF MEDIOCRITY?

    Directory of Open Access Journals (Sweden)

    Valentina CHIPER

    2014-11-01

    Full Text Available The link between freedom of speech and democracy is based on ideological legitimacy report. A new phenomenon which is worth noticing is the conversion of the freedom of expression from a freedom seen in certain aspects as a solitary freedom into a communication of the masses. Another challenge is prompted by the change of the traditional communication system at the dawn of technology, Internet and its various applications, as well as of the channels used. A weak point is the change in the values scale. If a journalist or a book is deemed good or valuable in terms of competence and ideas, these values are now unfortunately inspired by what we watch on TV. In this train of thoughts, reliable opinion leaders are no longer the same. Mediacracy turns into a synonym of mediocrity with affectivity and emotion prevailing over reason and instead of the communication of thoughts and opinions.

  8. Recent developments in turning hardened steels - A review

    Science.gov (United States)

    Sivaraman, V.; Prakash, S.

    2017-05-01

    Hard materials ranging from HRC 45 - 68 such as hardened AISI H13, AISI 4340, AISI 52100, D2 STL, D3 STEEL Steel etc., need super hard tool materials to machine. Turning of these hard materials is termed as hard turning. Hard turning makes possible direct machining of the hard materials and also eliminates the lubricant requirement and thus favoring dry machining. Hard turning is a finish turning process and hence conventional grinding is not required. Development of the new advanced super hard tool materials such as ceramic inserts, Cubic Boron Nitride, Polycrystalline Cubic Boron Nitride etc. enabled the turning of these materials. PVD and CVD methods of coating have made easier the production of single and multi layered coated tool inserts. Coatings of TiN, TiAlN, TiC, Al2O3, AlCrN over cemented carbide inserts has lead to the machining of difficult to machine materials. Advancement in the process of hard machining paved way for better surface finish, long tool life, reduced tool wear, cutting force and cutting temperatures. Micro and Nano coated carbide inserts, nanocomposite coated PCBN inserts, micro and nano CBN coated carbide inserts and similar developments have made machining of hardened steels much easier and economical. In this paper, broad literature review on turning of hardened steels including optimizing process parameters, cooling requirements, different tool materials etc., are done.

  9. Single-point ACT2 gene mutation in the Arabidopsis root hair mutant der1-3 affects overall actin organization, root growth and plant development.

    Science.gov (United States)

    Vaškebová, L; Šamaj, J; Ovecka, M

    2017-12-27

    The actin cytoskeleton forms a dynamic network in plant cells. A single-point mutation in the DER1 (deformed root hairs1) locus located in the sequence of ACTIN2, a gene for major actin in vegetative tissues of Arabidopsis thaliana, leads to impaired root hair development (Ringli C, Baumberger N, Diet A, Frey B, Keller B. 2002. ACTIN2 is essential for bulge site selection and tip growth during root hair development of Arabidopsis. Plant Physiology129: 1464-1472). Only root hair phenotypes have been described so far in der1 mutants, but here we demonstrate obvious aberrations in the organization of the actin cytoskeleton and overall plant development. Organization of the actin cytoskeleton in epidermal cells of cotyledons, hypocotyls and roots was studied qualitatively and quantitatively by live-cell imaging of transgenic lines carrying the GFP-FABD2 fusion protein and in fixed cells after phalloidin labelling. Patterns of root growth were characterized by FM4-64 vital staining, light-sheet microscopy imaging and microtubule immunolabelling. Plant phenotyping included analyses of germination, root growth and plant biomass. Speed of germination, plant fresh weight and total leaf area were significantly reduced in the der1-3 mutant in comparison with the C24 wild-type. Actin filaments in root, hypocotyl and cotyledon epidermal cells of the der1-3 mutant were shorter, thinner and arranged in more random orientations, while actin bundles were shorter and had altered orientations. The wavy pattern of root growth in der1-3 mutant was connected with higher frequencies of shifted cell division planes (CDPs) in root cells, which was consistent with the shifted positioning of microtubule-based preprophase bands and phragmoplasts. The organization of cortical microtubules in the root cells of the der1-3 mutant, however, was not altered. Root growth rate of the der1-3 mutant is not reduced, but changes in the actin cytoskeleton organization can induce a wavy root growth pattern

  10. Feasibility of in vivo three-dimensional T2*mapping using dicarboxy-PROXYL and CW-EPR-based single-point imaging.

    Science.gov (United States)

    Kubota, Harue; Komarov, Denis A; Yasui, Hironobu; Matsumoto, Shingo; Inanami, Osamu; Kirilyuk, Igor A; Khramtsov, Valery V; Hirata, Hiroshi

    2017-06-01

    The aim of this study was to demonstrate the feasibility of in vivo three-dimensional (3D) relaxation time T 2 * mapping of a dicarboxy-PROXYL radical using continuous-wave electron paramagnetic resonance (CW-EPR) imaging. Isotopically substituted dicarboxy-PROXYL radicals, 3,4-dicarboxy-2,2,5,5-tetra( 2 H 3 )methylpyrrolidin-(3,4- 2 H 2 )-(1- 15 N)-1-oxyl ( 2 H, 15 N-DCP) and 3,4-dicarboxy-2,2,5,5-tetra( 2 H 3 )methylpyrrolidin-(3,4- 2 H 2 )-1-oxyl ( 2 H-DCP), were used in the study. A clonogenic cell survival assay was performed with the 2 H-DCP radical using squamous cell carcinoma (SCC VII) cells. The time course of EPR signal intensities of intravenously injected 2 H, 15 N-DCP and 2 H-DCP radicals were determined in tumor-bearing hind legs of mice (C3H/HeJ, male, n = 5). CW-EPR-based single-point imaging (SPI) was performed for 3D T 2 * mapping. 2 H-DCP radical did not exhibit cytotoxicity at concentrations below 10 mM. The in vivo half-life of 2 H, 15 N-DCP in tumor tissues was 24.7 ± 2.9 min (mean ± standard deviation [SD], n = 5). The in vivo time course of the EPR signal intensity of the 2 H, 15 N-DCP radical showed a plateau of 10.2 ± 1.2 min (mean ± SD) where the EPR signal intensity remained at more than 90% of the maximum intensity. During the plateau, in vivo 3D T 2 * maps with 2 H, 15 N-DCP were obtained from tumor-bearing hind legs, with a total acquisition time of 7.5 min. EPR signals of 2 H, 15 N-DCP persisted long enough after bolus intravenous injection to conduct in vivo 3D T 2 * mapping with CW-EPR-based SPI.

  11. Cardiac EASE (Ensuring Access and Speedy Evaluation) – the impact of a single-point-of-entry multidisciplinary outpatient cardiology consultation program on wait times in Canada

    Science.gov (United States)

    Bungard, Tammy J; Smigorowsky, Marcie J; Lalonde, Lucille D; Hogan, Terry; Doliszny, Katharine M; Gebreyesus, Ghirmay; Garg, Sipi; Archer, Stephen L

    2009-01-01

    BACKGROUND: Universal access to health care is valued in Canada but increasing wait times for services (eg, cardiology consultation) raise safety questions. Observations suggest that deficiencies in the process of care contribute to wait times. Consequently, an outpatient clinic was designed for Ensuring Access and Speedy Evaluation (Cardiac EASE) in a university group practice, providing cardiac consultative services for northern Alberta. Cardiac EASE has two components: a single-point-of-entry intake service (prospective testing using physician-approved algorithms and previsit triage) and a multidisciplinary clinic (staffed by cardiologists, nurse practitioners and doctoral-trained pharmacists). OBJECTIVES: It was hypothesized that Cardiac EASE would reduce the time to initial consultation and a definitive diagnosis, and also increase the referral capacity. METHODS: The primary and secondary outcomes were time from referral to initial consultation, and time to achieve a definitive diagnosis and management plan, respectively. A conventionally managed historical control group (three-month pre-EASE period in 2003) was compared with the EASE group (2004 to 2006). The conventional referral mechanism continued concurrently with EASE. RESULTS: A comparison between pre-EASE (n=311) and EASE (n=3096) revealed no difference in the mean (± SD) age (60±16 years), sex (55% and 52% men, respectively) or reason for referral, including chest pain (31% and 40%, respectively) and arrhythmia (27% and 29%, respectively). Cardiac EASE reduced the time to initial cardiac consultation (from 71±45 days to 33±19 days) and time to a definitive diagnosis (from 120±86 days to 51±58 days) (P<0.0001). The annual number of new referrals increased from 1512 in 2002 to 2574 in 2006 due to growth in the Cardiac EASE clinic. The number of patients seen through the conventional referral mechanism and their wait times remained constant during the study period. CONCLUSIONS: Cardiac EASE reduced

  12. Models and Algorithms for Tracking Target with Coordinated Turn Motion

    Directory of Open Access Journals (Sweden)

    Xianghui Yuan

    2014-01-01

    Full Text Available Tracking target with coordinated turn (CT motion is highly dependent on the models and algorithms. First, the widely used models are compared in this paper—coordinated turn (CT model with known turn rate, augmented coordinated turn (ACT model with Cartesian velocity, ACT model with polar velocity, CT model using a kinematic constraint, and maneuver centered circular motion model. Then, in the single model tracking framework, the tracking algorithms for the last four models are compared and the suggestions on the choice of models for different practical target tracking problems are given. Finally, in the multiple models (MM framework, the algorithm based on expectation maximization (EM algorithm is derived, including both the batch form and the recursive form. Compared with the widely used interacting multiple model (IMM algorithm, the EM algorithm shows its effectiveness.

  13. Isentropic compression studies using the NHMFL single turn

    Energy Technology Data Exchange (ETDEWEB)

    Tasker, Douglas G [Los Alamos National Laboratory; Mielke, Charles [Los Alamos National Laboratory; Rodriguez, George [Los Alamos National Laboratory; Rickel, Dwight [Los Alamos National Laboratory

    2010-10-19

    Magnetic isentropic compression experiments (ICE) provide the most accurate shock free compression data for materials at megabar stresses. Recent ICE experiments performed on the Sandia Z-machine (Asay, 1999) and at the Los Alamos High Explosive Pulsed Power facility (Tasker, 2006) are providing our nation with data on material properties in extreme dynamic high stress environments. The LANL National High Magnetic Field Laboratory (NHMFL) can offer a less complex ICE experiment at high stresses (up to {approx}1Mbar) with a high sample throughput and relatively low cost. This is not to say that the NHMFL technique will replace the other methods but rather complement them. For example, NHMFL-ICE is ideal for the development of advanced diagnostics, e.g., to detect phase changes. We will discuss the physics of the NHMFL-ICE experiments and present data from the first proof-of-principle experiments that were performed in September 2010.

  14. Turning nuclear communications inside out

    International Nuclear Information System (INIS)

    Besenyei, Elisabeth; Czibolya, Laszlo

    2002-01-01

    Due to debates on the security of energy supply in the European Union, the international efforts on the implementation of Kyoto protocol and the forthcoming liberalization of the electrical energy market the attention of Hungarian decision-makers was focused on energy related problems. Discussions started on the future role of nuclear power and anti-nuclear environmentalists became more active in their criticism. Changes were needed in the approach and practice of communication on nuclear energy. Previous practice turned to be inefficient in dialogue with different social and influential groups. Public information could not be considered any more as an activity explaining measures to cope with incidents and accidents or giving technical answers to mostly superficial statements on allegedly unsafe features and solutions in nuclear industry. It was time to change the paradigm and to turn the communication into a powerful tool to put forward the arguments, to show the achievements and facts and to explain the efforts in addressing public concerns. The new paradigm turned the previous outside-in approach to a new inside-out type of behavior. Instead of reacting to the attacks coming from outside the new approach means first of all commitment to be open and pro-active in communication and to act in close cooperation with all interested organizations and institutions. The three pillars of the new paradigm, commitment, communication and co-operation are applicable not only for the nuclear industry, but also for the governmental agencies (regulatory bodies, health and emergency authorities etc.) and for the wide range of technical, scientific and civil organizations. Public information should be turned from a burden to a challenge for open, technically valid and honest dialogue. This active communication approach is illustrated by some new initiatives in public information in Hungary. Following the successful Nuclear Academy for Journalists formed new Section of Nuclear

  15. AE Monitoring of Diamond Turned Rapidly Soldified Aluminium 443

    International Nuclear Information System (INIS)

    Onwuka, G; Abou-El-Hossein, K; Mkoko, Z

    2017-01-01

    The fast replacement of conventional aluminium with rapidly solidified aluminium alloys has become a noticeable trend in the current manufacturing industries involved in the production of optics and optical molding inserts. This is as a result of the improved performance and durability of rapidly solidified aluminium alloys when compared to conventional aluminium. Melt spinning process is vital for manufacturing rapidly solidified aluminium alloys like RSA 905, RSA 6061 and RSA 443 which are common in the industries today. RSA 443 is a newly developed alloy with few research findings and huge research potential. There is no available literature focused on monitoring the machining of RSA 443 alloys. In this research, Acoustic Emission sensing technique was applied to monitor the single point diamond turning of RSA 443 on an ultrahigh precision lathe machine. The machining process was carried out after careful selection of feed, speed and depths of cut. The monitoring process was achieved with a high sampling data acquisition system using different tools while concurrent measurement of the surface roughness and tool wear were initiated after covering a total feed distance of 13km. An increasing trend of raw AE spikes and peak to peak signal were observed with an increase in the surface roughness and tool wear values. Hence, acoustic emission sensing technique proves to be an effective monitoring method for the machining of RSA 443 alloy. (paper)

  16. Breaking New Ground with High Resolution Turn-By-Turn BPMs at the ESRF

    CERN Document Server

    Farvacque, L; Scheidt, K

    2001-01-01

    This High-Resolution, Turn-by-Turn BPM system is a low-cost extension to the existing BPM system, based on the RF-multiplexing concept, used for slow Closed-Orbit measurements. With this extension Beam Position measurements in both planes, at all (224) BPMs in the 844 m ESRF Storage Ring, for up to 2048 Orbit Turns with 1 μm resolution are performed. The data acquisition is synchronised to a single, flat 1 μs, transverse deflection kick to the 1μs beamfill in the 2.8μs revolution period. The high quality of this synchronisation, together with the good reproducibility of the deflection kick and the overall stability of the Closed Orbit beam allows to repeat the kick and acquisition in many cycles. The subsequent averaging of the data obtained in these cycles yields the 1um resolution. The latter allows lattice measurements with high precision such as the localisation of very small focussing errors and modulation in Beta values and phase advances. It also finds an unique ...

  17. Evaluation of cutting force uncertainty components in turning

    DEFF Research Database (Denmark)

    Axinte, Dragos Aurelian; Belluco, Walter; De Chiffre, Leonardo

    2000-01-01

    A procedure is proposed for the evaluation of those uncertainty components of a single cutting force measurement in turning that are related to the contributions of the dynamometer calibration and the cutting process itself. Based on an empirical model including errors form both sources, the unce...

  18. William Friedman, Geneticist Turned Cryptographer.

    Science.gov (United States)

    Goldman, Irwin L

    2017-05-01

    William Friedman (1891-1969), trained as a plant geneticist at Cornell University, was employed at Riverbank Laboratories by the eccentric millionaire George Fabyan to work on wheat breeding. Friedman, however, soon became intrigued by and started working on a pet project of Fabyan's involving the conjecture that Francis Bacon, a polymath known for the study of ciphers, was the real author of Shakespeare's plays. Thus, beginning in ∼1916, Friedman turned his attention to the so called "Baconian cipher," and developed decryption techniques that bore similarity to approaches for solving problems in population genetics. His most significant, indeed pathbreaking, work used ideas from genetics and statistics, focusing on analysis of the frequencies of letters in language use. Although he had transitioned from being a geneticist to a cryptographer, his earlier work had resonance in his later pursuits. He soon began working directly for the United States government and produced solutions used to solve complex military ciphers, in particular to break the Japanese Purple code during World War II. Another important legacy of his work was the establishment of the Signal Intelligence Service and eventually the National Security Agency. Copyright © 2017 by the Genetics Society of America.

  19. Notes on the Spatial Turn

    Directory of Open Access Journals (Sweden)

    Stipe Grgas

    2012-06-01

    Full Text Available On the basis of ever-mounting evidence, amongst which is the “zone” problematic of the Zadar conference that occassioned these notes, it can be concluded that the spatial turn has insinuated itself as an all-pervading heuristic tool throughout the humanities and the social sciences. The extent to which space and spatiality have usurped the central stage in the various branches of reasearch can be gauged by admonishments that what we are witnessing is a new fundamentalism that has simply inverted the terms of the dualism of time and space (May and Thrift 2001: “Introduction”. According to Michael Dear the sway of space is manifested in multifold ways: in the ubiquity of spatial analysis in social theories and practices; in the explosion of publications devoted to the exploration of the interface of the social and the spatial; in the reintegration of human geography into various domains of knowledge; in the focus given to difference and the consequent diversification of theoretical and empirical practices; in a theoretically informed exploration of the relation between geographical knowledge and social action; and, finally, in the unprecedented proliferation of research agendas and publications pertaining to these isuuses (Dear 2001: 24. Two recent collections of papers are indicative of the ubiquity of spatial issues in scholarly work.

  20. Clinical evaluation of an automated turning bed.

    Science.gov (United States)

    Melland, H I; Langemo, D; Hanson, D; Olson, B; Hunter, S

    1999-01-01

    The purposes of this study were to assess client comfort and sleep quality, client physiologic response (skin and respiratory status), the effect on the need for caregiver assistance, and cost when using an automated turning bed. Nonexperimental, evaluative study. Twenty-four adult home or long-term care resident subjects who had a degenerative disease, spinal cord injury, stroke, cerebral palsy, or back surgery. Each subject agreed to use the automated turning bed for four weeks. Researchers completed a demographic survey and skin assessment, and assessed each subject for pressure ulcer risk and for the need of assistance of a care giver for turning before and after the four weeks of using the turning bed. Subjects rated the turning bed in terms of comfort and sleep quality. Subjects rated the turning bed as more comfortable than their own bed and expressed satisfaction at the pain relief attained when on the turning bed. While using the turning bed, there was a significant improvement in sleep quality. No skin breakdown or deterioration in respiratory status occurred. Fewer subjects required the assistance of a caregiver for turning when on the turning bed. This automated turning bed shows great promise in meeting a need for patients with limited mobility whether they are homebound or in a residential community. Future studies that further investigate use of the turning bed for postoperative back patients while still in the acute care setting are indicated. Replicative studies with a larger sample size are also indicated.

  1. 32 CFR 636.23 - Turning movements.

    Science.gov (United States)

    2010-07-01

    ... Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL... movements. (a) U-turns are prohibited on all streets in the cantonment area. (b) Right-turns will be made from a position as close to the right edge or right curb of the roadway as possible. (c) Left-turns...

  2. Study on a magneto-rheological removal process of periodic turning marks

    Science.gov (United States)

    Jeon, Min-Woo; Jeong, Byeong-Joon; Hyun, Sang-Won; Lee, Kye-Sung; Han, Jeong-Yeol; Kim, Geon-Hee

    2017-10-01

    Single Point Diamond Turning (SPDT) has the potential to cost-effectively manufacture optical materials such as metals and plastic types. However, SPDT generally leaves tool marks on the machined surfaces, which creates problems that can deteriorate the optical performance. Several processes have been studied to eliminate the tool marks caused by SPDT, but it was difficult to carry out without the additional defects like sub-surface damages and other tool marks. To overcome this weakness, we investigated the Magneto-Rheological Finishing (MRF) process to effectively remove the periodic micro structures without surface deterioration for optical performance. The workpiece used in the experiment is a mirror plated with electroless nickel-phosphorus. Through the processing of the SPDT, an initial surface gets periodic tool marks, which have a height of 1.1 μm and a pitch of 20 μm. We studied on the reduction rate of the turning marks by the MRF process with some different conditions of uniform removal. The quantitative analysis of the surface roughness and residual marks was performed using a scanning low-coherence interferometer and through the Power Spectral Density (PSD) respectively. The results showed that reduction rates of tool marks depend on the angles (0, 45, and 90 degs) between the turning direction of the tool marks and the rotation direction of MR wheel. In the case of 45 degs, it indicated the fastest reduction rate.

  3. Synthetic Aperture Computation as the Head is Turned in Binaural Direction Finding

    Directory of Open Access Journals (Sweden)

    Duncan Tamsett

    2017-03-01

    Full Text Available Binaural systems measure instantaneous time/level differences between acoustic signals received at the ears to determine angles λ between the auditory axis and directions to acoustic sources. An angle λ locates a source on a small circle of colatitude (a lamda circle on a sphere symmetric about the auditory axis. As the head is turned while listening to a sound, acoustic energy over successive instantaneous lamda circles is integrated in a virtual/subconscious field of audition. The directions in azimuth and elevation to maxima in integrated acoustic energy, or to points of intersection of lamda circles, are the directions to acoustic sources. This process in a robotic system, or in nature in a neural implementation equivalent to it, delivers its solutions to the aurally informed worldview. The process is analogous to migration applied to seismic profiler data, and to that in synthetic aperture radar/sonar systems. A slanting auditory axis, e.g., possessed by species of owl, leads to the auditory axis sweeping the surface of a cone as the head is turned about a single axis. Thus, the plane in which the auditory axis turns continuously changes, enabling robustly unambiguous directions to acoustic sources to be determined.

  4. Eradication of large solid tumors by gene therapy with a T cell receptor targeting a single cancer-specific point mutation

    Science.gov (United States)

    Leisegang, Matthias; Engels, Boris; Schreiber, Karin; Yew, Poh Yin; Kiyotani, Kazuma; Idel, Christian; Arina, Ainhoa; Duraiswamy, Jaikumar; Weichselbaum, Ralph R.; Uckert, Wolfgang; Nakamura, Yusuke; Schreiber, Hans

    2015-01-01

    Purpose Cancers usually contain multiple unique tumor-specific antigens produced by single amino acid substitutions (AAS) and encoded by somatic non-synonymous single nucleotide substitutions. We determined whether adoptively transferred T cells can reject large, well-established solid tumors when engineered to express a single type of T cell receptor (TCR) that is specific for a single AAS. Experimental Design By exome and RNA sequencing of an UV-induced tumor, we identified an AAS in p68 (mp68), a co-activator of p53. This AAS seemed to be an ideal tumor-specific neoepitope because it is encoded by a trunk mutation in the primary autochthonous cancer and binds with highest affinity to the MHC. A high-avidity mp68-specific TCR was used to genetically engineer T cells as well as to generate TCR-transgenic mice for adoptive therapy. Results When the neoepitope was expressed at high levels and by all cancer cells, their direct recognition sufficed to destroy intra-tumor vessels and eradicate large, long-established solid tumors. When the neoepitope was targeted as autochthonous antigen, T cells caused cancer regression followed by escape of antigen-negative variants. Escape could be thwarted by expressing the antigen at increased levels in all cancer cells or by combining T cell therapy with local irradiation. Therapeutic efficacies of TCR-transduced and TCR-transgenic T cells were similar. Conclusions Gene therapy with a single TCR targeting a single AAS can eradicate large established cancer but a uniform expression and/or sufficient levels of the targeted neoepitope or additional therapy are required to overcome tumor escape. PMID:26667491

  5. Adjacent, distal, or combination of point-selective effects of acupuncture on temporomandibular joint disorders: A randomized, single-blind, assessor-blind controlled trial

    Directory of Open Access Journals (Sweden)

    Kyung-Won Kang

    2012-12-01

    Conclusion: Our results suggest that point-selective effects among adjacent, distal, or a combination of acupoints are hardly associated with pain intensity or palpation index in participants with TMDs. Larger sample size trials are required to overcome the shortcomings of the study.

  6. The information-theoretic turn

    Directory of Open Access Journals (Sweden)

    Blevins James P.

    2013-01-01

    Full Text Available Over the past decade, information theory has been applied to the analysis of a successively broader range of morphological phenomena. Interestingly, this tradition has arisen independently of the linguistic applications of information theory dating from the 1950’s. Instead, the point of origin for current work lies in a series of studies of morphological processing in which Kostić and associates develop a statistical notion of ‘morphological information’ based on ‘uncertainty’ and ‘uncertainty reduction’. From these initial studies, analyses based on statistical notions of information have been applied to general problems of morphological description and typological classification, leading to a formal rehabilitation of the complex system perspective of traditional WP models.

  7. A NOVEL SINGLE IMPEDANCE NETWORK BASED NEUTRAL POINT CLAMPED SEVEN LEVEL THREE PHASE INVETER WITH REDUCED CLAMPING DIODES FOR REGENERATIVE APPLICATIONS

    OpenAIRE

    T. A. Raghavendiran; C.L.Kuppuswamy

    2012-01-01

    A Multilevel Inverter (MLI) can eliminate the need for the step-up transformer and reduce the harmonics produced by the inverter. This paper presents Neutral Point Clamped (NPC) seven level inverter with less number of clamping diodes which is suitable for regenerative loads such as three phase induction motor with regenerative braking. To reduce the stress across the main switches, diodes are clamped anti-parallel to the main switches. In Earlier configurations, the numbers of clamping diode...

  8. Ab initio analysis of a vacancy and a self-interstitial near single crystal silicon surfaces: Implications for intrinsic point defect incorporation during crystal growth from a melt

    Energy Technology Data Exchange (ETDEWEB)

    Kamiyama, Eiji; Sueoka, Koji [Department of Communication Engineering, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719-1197 (Japan); Vanhellemont, Jan [Department of Solid State Sciences, Ghent University, Krijgslaan 281-S1, Gent 9000 (Belgium)

    2012-10-15

    The microscopic model of the Si (001) crystal surface was investigated by first principles calculations to clarify the behavior of intrinsic point defects near crystal surfaces. A c(4 x 2) structure model was used to describe the crystal surface in contact with vacuum. The calculations show lower formation energy near the surface and the existence of formation energy differences between the surface and the bulk for both types of intrinsic point defects. The tetrahedral (T)-site and the dumbbell (DB)-site, in which a Si atom is captured from the surface and forms a self-interstitial, are found as stable sites near the third atomic layer. The T-site has a barrier of 0.48 eV, whereas the DB-site has no barrier for the interstitial to penetrate into the crystal from the vacuum. Si atoms in a melt can migrate and reach at the third layer during crystal growth when bulk diffusion coefficient is used. Therefore, the melt/solid interface is always a source of intrinsic point defects. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  9. The analysis of dyes in ball point pen inks on single paper fibres using laser desorption ionisation time of flight mass spectrometry (LDI-TOFMS).

    Science.gov (United States)

    Matthews, Broderick; Walker, G Stewart; Kobus, Hilton; Pigou, Paul; Bird, Carolyne; Smith, Glyn

    2011-06-15

    An important requisite for the forensic analysis of inks on documents is that damage to the document is avoided or minimised. This paper describes a technique for dye identification in ballpoint pen inks using LDI-TOFMS on single ink bearing paper fibres and its application to a case. A single ink bearing paper fibre can be prised from the surface of the document under a stereo microscope and presented to the instrument for analysis without further treatment. This sampling process causes imperceptible damage to the surface of the document. Clear mass spectrometric identification of the ink dyes is obtained. A case example is provided to illustrate the practical application of the technique. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  10. An SVM-Based Classifier for Estimating the State of Various Rotating Components in Agro-Industrial Machinery with a Vibration Signal Acquired from a Single Point on the Machine Chassis

    Directory of Open Access Journals (Sweden)

    Ruben Ruiz-Gonzalez

    2014-11-01

    Full Text Available The goal of this article is to assess the feasibility of estimating the state of various rotating components in agro-industrial machinery by employing just one vibration signal acquired from a single point on the machine chassis. To do so, a Support Vector Machine (SVM-based system is employed. Experimental tests evaluated this system by acquiring vibration data from a single point of an agricultural harvester, while varying several of its working conditions. The whole process included two major steps. Initially, the vibration data were preprocessed through twelve feature extraction algorithms, after which the Exhaustive Search method selected the most suitable features. Secondly, the SVM-based system accuracy was evaluated by using Leave-One-Out cross-validation, with the selected features as the input data. The results of this study provide evidence that (i accurate estimation of the status of various rotating components in agro-industrial machinery is possible by processing the vibration signal acquired from a single point on the machine structure; (ii the vibration signal can be acquired with a uniaxial accelerometer, the orientation of which does not significantly affect the classification accuracy; and, (iii when using an SVM classifier, an 85% mean cross-validation accuracy can be reached, which only requires a maximum of seven features as its input, and no significant improvements are noted between the use of either nonlinear or linear kernels.

  11. The Bulletin turns the page

    CERN Multimedia

    2006-01-01

    Today, the paper version of the CERN Bulletin has a new look, the first since the 1970s. The new layout, which has been designed to improve readability, is part of an ongoing effort to improve internal communication at CERN. The Bulletin is the Organization's main tool for communication with the CERN community. It keeps everyone abreast of information that is important and essential for our working life at CERN. It plays an important role in keeping us up to date with social and scientific developments at the Laboratory. And it should be a force for cohesion across this very diverse organization. At the same time, the distribution for the printed Bulletin is being changed from individual mailboxes to distribution points around the Laboratory. This reflects changing reading habits, with the on-line version gaining a steadily increasing readership. For some time now, the paper Bulletin has been published fortnightly. However, the on-line version is updated weekly, so I encourage you all to look at it. In addi...

  12. Realistic page-turning of electronic books

    Science.gov (United States)

    Fan, Chaoran; Li, Haisheng; Bai, Yannan

    2014-01-01

    The booming electronic books (e-books), as an extension to the paper book, are popular with readers. Recently, many efforts are put into the realistic page-turning simulation o f e-book to improve its reading experience. This paper presents a new 3D page-turning simulation approach, which employs piecewise time-dependent cylindrical surfaces to describe the turning page and constructs smooth transition method between time-dependent cylinders. The page-turning animation is produced by sequentially mapping the turning page into the cylinders with different radii and positions. Compared to the previous approaches, our method is able to imitate various effects efficiently and obtains more natural animation of turning page.

  13. Breath holding during the turn in competitive swimming.

    Science.gov (United States)

    Craig, A B

    1986-08-01

    Breath holding times were measured during competition and averaged 5.0 sec in the breaststroke events, 4.3 sec in freestyle, 3.7 sec in butterfly, and 3.3 sec in backstroke. These times represented approximately 30% of the total time of swimming breaststroke and freestyle races but only 20% of the time of backstroke and butterfly events. Pulmonary gas exchanges of O2 and CO2 were studied in eight male swimmers during the first turn after the start of a swim and during the third turn after continuous swimming. It was concluded that biomechanical considerations of optimizing a turn are in most circumstances not limited by the increased PCO2 and the decreased PO2 in the alveoli related to the brief period of breath holding. In turns which last longer than about 5.5 s, the swimmers may experience a strong urge to breathe. This "breaking point" sensation is brief and need not compromise the conclusion of a well-executed turn.

  14. Tipping Point

    Medline Plus

    Full Text Available ... en español Blog About OnSafety CPSC Stands for Safety The Tipping Point Home > 60 Seconds of Safety (Videos) > The Tipping Point The Tipping Point by ... danger death electrical fall furniture head injury product safety television tipover tv Watch the video in Adobe ...

  15. The effect of correlated and point defects on the vortex lattice melting transition in single crystal YBa2Cu3O7-δ

    International Nuclear Information System (INIS)

    Kwok, W.K.; Fleshler, S.; Welp, U.; Downey, J.; Crabtree, G.W.; Fendrich, J. Giapintzakis, J.

    1993-08-01

    The vortex melting transition T m in several untwinned and twinned crystals measured resistively in fields up to 8 Tesla. A Lindemann criterion for vortex lattice melting is obtained in addition to a sharp hysteresis in the magnetoresistance at B m supporting a first order phase transition. The anisotropy of twin boundary pinning and its reduction of the ''kink'' in ρ(T) associated with the first order melting transition is discussed in samples with very dilute twin boundaries. We also report on direct suppression of melting transition by intrinsic pinning for H parallel ab and by electron-irradiation-induced point defects

  16. Cost-effectiveness of lumbar discectomy and single-level fusion for spondylolisthesis: experience with the NeuroPoint-SD registry.

    Science.gov (United States)

    Mummaneni, Praveen V; Whitmore, Robert G; Curran, Jill N; Ziewacz, John E; Wadhwa, Rishi; Shaffrey, Christopher I; Asher, Anthony L; Heary, Robert F; Cheng, Joseph S; Hurlbert, R John; Douglas, Andrea F; Smith, Justin S; Malhotra, Neil R; Dante, Stephen J; Magge, Subu N; Kaiser, Michael G; Abbed, Khalid M; Resnick, Daniel K; Ghogawala, Zoher

    2014-06-01

    There is significant practice variation and uncertainty as to the value of surgical treatments for lumbar spine disorders. The authors' aim was to establish a multicenter registry to assess the efficacy and costs of common lumbar spinal procedures by using prospectively collected outcomes. An observational prospective cohort study was completed at 13 academic and community sites. Patients undergoing single-level fusion for spondylolisthesis or single-level lumbar discectomy were included. The 36-Item Short Form Health Survey (SF-36) and Oswestry Disability Index (ODI) data were obtained preoperatively and at 1, 3, 6, and 12 months postoperatively. Power analysis estimated a sample size of 160 patients: lumbar disc (125 patients) and lumbar listhesis (35 patients). The quality-adjusted life year (QALY) data were calculated using 6-dimension utility index scores. Direct costs and complication costs were estimated using Medicare reimbursement values from 2011, and indirect costs were estimated using the human capital approach with the 2011 US national wage index. Total costs equaled $14,980 for lumbar discectomy and $43,852 for surgery for lumbar spondylolisthesis. There were 198 patients enrolled over 1 year. The mean age was 46 years (49% female) for lumbar discectomy (n = 148) and 58.1 years (60% female) for lumbar spondylolisthesis (n = 50). Ten patients with disc herniation (6.8%) and 1 with listhesis (2%) required repeat operation at 1 year. The overall 1-year follow-up rate was 88%. At 30 days, both lumbar discectomy and single-level fusion procedures were associated with significant improvements in ODI, visual analog scale, and SF-36 scores (p = 0.0002), which persisted at the 1-year evaluation (p spondylolisthesis. One-year cost per QALY was obtained, and this cost per QALY is expected to improve further by 2 years. This work sets the stage for real-world analysis of the value of health interventions.

  17. Mechanics of the Fouetté turn.

    Science.gov (United States)

    Imura, Akiko; Yeadon, M R

    2010-12-01

    The Fouetté turn in classical ballet is performed repeatedly on one leg with swinging of the free limbs, producing a continued sequence of turns with one turn leading into the next. The purpose of this study was to determine the possible time history profiles of the twisting torque between the supporting leg and the remainder of the body that will allow continued performances of the Fouetté turn. Simulations were performed using a model which comprised the supporting leg and the remainder of the body to find torque profiles that maintain the initial angular velocity so that the state after one revolution is the same as the initial state. The solution space of torque profiles was determined for various rotation times and coefficients of friction between foot and floor. As the time for one revolution became shorter the solution space became smaller and for a given turn time there was a lower limit on the coefficient of friction. As the frictional coefficient became smaller the solution space became smaller and for a given coefficient there was a lower limit on the turn time. Turns of a given tempo can be performed on floors with different friction by modifying the twisting torque profile. When a turn is completed with a net change in angular velocity this can be compensated for in the next turn by adjusting the twisting torque profile. Copyright © 2010 Elsevier B.V. All rights reserved.

  18. Development and Positioning Accuracy Assessment of Single-Frequency Precise Point Positioning Algorithms by Combining GPS Code-Pseudorange Measurements with Real-Time SSR Corrections

    Directory of Open Access Journals (Sweden)

    Miso Kim

    2017-06-01

    Full Text Available We have developed a suite of real-time precise point positioning programs to process GPS pseudorange observables, and validated their performance through static and kinematic positioning tests. To correct inaccurate broadcast orbits and clocks, and account for signal delays occurring from the ionosphere and troposphere, we applied State Space Representation (SSR error corrections provided by the Seoul Broadcasting System (SBS in South Korea. Site displacements due to solid earth tide loading are also considered for the purpose of improving the positioning accuracy, particularly in the height direction. When the developed algorithm was tested under static positioning, Kalman-filtered solutions produced a root-mean-square error (RMSE of 0.32 and 0.40 m in the horizontal and vertical directions, respectively. For the moving platform, the RMSE was found to be 0.53 and 0.69 m in the horizontal and vertical directions.

  19. A cultural turn in New Testament studies?

    African Journals Online (AJOL)

    2016-06-30

    Jun 30, 2016 ... The late twentieth century's 'linguistic turn' marked the beginning of a new consciousness in hermeneutics and even epistemology in New Testament (NT) studies.1 This turn was related to a larger spectrum of changes sometimes referred to as 'culture wars' in the human and social sciences.2 These ...

  20. performance characteristics of a cam turning attachment

    African Journals Online (AJOL)

    Dr Obe

    up of a suitable flexible shaft, a lathe spindle clutch and a shaft supported in ball bearings to carry and drive the master piece. This is shown in figure. 1. The hydraulic turning unit which is intended for cylindrical turning has been modified and used in conjunction with the drive system, as shown in figure. 2, for non cylindrical ...

  1. Towards a Practice Turn in EU Studies

    DEFF Research Database (Denmark)

    Adler-Nissen, Rebecca

    2016-01-01

    the potential of a practice turn in EU studies for both theory (overcoming dualism, replacing substantialism with processualism and rethinking power) and methods (including unstructured interviews, fieldwork and participant observation). A practice turn will force us to rethink core assumptions about the EU...

  2. Where Could an Anthropological Turn Lead the Humanities and the Arts

    Directory of Open Access Journals (Sweden)

    Hans Ulrich Gumbrecht

    2012-05-01

    Full Text Available This paper discusses the possible significations of a so-called anthropological turn in the field of the Humanities and Arts. The text focuses on the meaning of Anthropology and its application in these fields. In this sense, two great conceptions of Anthropology are distinguished: an understanding of Anthropology as an attempt at a singular, meta-historical and transcultural determination of a valid definition of what it means to be human; and another whose use predominates in the Anglo-American contemporary context, in which different ways of being human are considered, instead of a single conception. The text also discusses the word ‘reviravolta’ [overturn] which the Humanities and the Arts have been trying to point out and identify as what is or should be the contemporary thought in those fields.

  3. Structure-Guided, Single-Point Modifications in the Phosphinic Dipeptide Structure Yield Highly Potent and Selective Inhibitors of Neutral Aminopeptidases

    Energy Technology Data Exchange (ETDEWEB)

    Vassiliou, Stamatia; Węglarz-Tomczak, Ewelina; Berlicki, Łukasz; Pawełczak, Małgorzata; Nocek, Bogusław; Mulligan, Rory; Joachimiak, Andrzej; Mucha, Artur

    2014-10-09

    Seven crystal structures of alanyl aminopeptidase from Neisseria meningitides (the etiological agent of meningitis, NmAPN) complexed with organophosphorus compounds were resolved to determine the optimal inhibitor-enzyme interactions. The enantiomeric phosphonic acid analogs of Leu and hPhe, which correspond to the P1 amino acid residues of well-processed substrates, were used to assess the impact of the absolute configuration and the stereospecific hydrogen bond network formed between the aminophosphonate polar head and the active site residues on the binding affinity. For the hPhe analog, an imperfect stereochemical complementarity could be overcome by incorporating an appropriate P1 side chain. The constitution of P1'-extended structures was rationally designed and the lead, phosphinic dipeptide hPhePψ[CH2]Phe, was modified in a single position. Introducing a heteroatom/heteroatom-based fragment to either the P1 or P1' residue required new synthetic pathways. The compounds in the refined structure were low nanomolar and subnanomolar inhibitors of N. meningitides, porcine and human APNs, and the reference leucine aminopeptidase (LAP). The unnatural phosphinic dipeptide analogs exhibited a high affinity for monozinc APNs associated with a reasonable selectivity versus dizinc LAP. Another set of crystal structures containing the NmAPN dipeptide ligand were used to verify and to confirm the predicted binding modes; furthermore, novel contacts, which were promising for inhibitor development, were identified, including a π-π stacking interaction between a pyridine ring and Tyr372.

  4. Accurate approach for determining fresh-water carbonate (H2CO3(*)) alkalinity, using a single H3PO4 titration point.

    Science.gov (United States)

    Birnhack, Liat; Sabach, Sara; Lahav, Ori

    2012-10-15

    A new, simple and accurate method is introduced for determining H(2)CO(3)(*) alkalinity in fresh waters dominated by the carbonate weak-acid system. The method relies on a single H(3)PO(4) dosage and two pH readings (acidic pH value target: pH~4.0). The computation algorithm is based on the concept that the overall alkalinity mass of a solution does not change upon the addition of a non-proton-accepting species. The accuracy of the new method was assessed batch-wise with both synthetic and actual tap waters and the results were compared to those obtained from two widely used alkalinity analysis methods (titration to pH~4.5 and the Gran titration method). The experimental results, which were deliberately obtained with simple laboratory equipment (glass buret, general-purpose pH electrode, magnetic stirrer) proved the method to be as accurate as the conventional methods at a wide range of alkalinity values (20-400 mg L(-1) as CaCO(3)). Analysis of the relative error attained in the proposed method as a function of the target (acidic) pH showed that at the range 4.0pHalkalinity measurement is also described. Copyright © 2012 Elsevier B.V. All rights reserved.

  5. SAAFEC: Predicting the Effect of Single Point Mutations on Protein Folding Free Energy Using a Knowledge-Modified MM/PBSA Approach.

    Science.gov (United States)

    Getov, Ivan; Petukh, Marharyta; Alexov, Emil

    2016-04-07

    Folding free energy is an important biophysical characteristic of proteins that reflects the overall stability of the 3D structure of macromolecules. Changes in the amino acid sequence, naturally occurring or made in vitro, may affect the stability of the corresponding protein and thus could be associated with disease. Several approaches that predict the changes of the folding free energy caused by mutations have been proposed, but there is no method that is clearly superior to the others. The optimal goal is not only to accurately predict the folding free energy changes, but also to characterize the structural changes induced by mutations and the physical nature of the predicted folding free energy changes. Here we report a new method to predict the Single Amino Acid Folding free Energy Changes (SAAFEC) based on a knowledge-modified Molecular Mechanics Poisson-Boltzmann (MM/PBSA) approach. The method is comprised of two main components: a MM/PBSA component and a set of knowledge based terms delivered from a statistical study of the biophysical characteristics of proteins. The predictor utilizes a multiple linear regression model with weighted coefficients of various terms optimized against a set of experimental data. The aforementioned approach yields a correlation coefficient of 0.65 when benchmarked against 983 cases from 42 proteins in the ProTherm database. the webserver can be accessed via http://compbio.clemson.edu/SAAFEC/.

  6. High genetic homogeneity points to a single introduction event responsible for invasion of Cotton leaf curl Multan virus and its associated betasatellite into China.

    Science.gov (United States)

    Du, Zhenguo; Tang, Yafei; He, Zifu; She, Xiaoman

    2015-10-07

    Cotton leaf curl Multan virus (CLCuMuV) is a Whitefly Transmitted Geminivirus (WTG) endemic to the India subcontinent and is notorious as a causal agent of cotton leaf curl disease (CLCuD), a major constraint to cotton production in south Asia. We found CLCuMuV infecting Hibiscus rosa-sinensis in Guangzhou, China in 2006. The spread and evolution of the invading CLCuMuV were monitored in the following nine years. CLCuMuV spread rapidly in the last nine years and became established in Southern China. It infects at least five malvaceous plant species, H. rosa-sinensis, H. esculentus, Malvaiscus arboreus, Gossypium hirsutum and H. cannabinus. Complete nucleotide sequences of 34 geographically and/or temporally distinct CLCuMuV isolates were determined and analyzed together with six other publicly available genomes of CLCuMuV occurring in China. The 40 CLCuMuV isolates were found to share > 99 % nucleotide sequence identity with each other. In all cases tested, the CLCuMuVs were associated with a CLCuMuB. The 36 CLCuMuBs (30 sequenced by us) shared > 98 % nucleotide sequence identity. The high genetic homogeneity of CLCuMuV and CLCuMuB in China suggests the establishment of them from a single founder event.

  7. Vehicle kinematics in turns and the role of cornering lamps in driver vision.

    Science.gov (United States)

    2010-11-01

    "SAE Recommended Practice J852 and ECE Regulations 119 and 48 for cornering lamps : were compared. Photometric points described in each specification were then compared : to naturalistic low-speed turn trajectories produced by 87 drivers. Future loca...

  8. The Third Turn toward the Social: Nancy Welch's "Living Room," Tony Scott's "Dangerous Writing," and Rhetoric and Composition's Turn toward Grassroots Political Activism

    Science.gov (United States)

    Kinney, Kelly; Girshin, Thomas; Bowlin, Barrett

    2013-01-01

    This review essay examines recent texts by Nancy Welch and Tony Scott, both of which use embodied activism as a starting point for their inquiries. Taken together, these works point to a distinct shift in composition studies' turn toward the social, one that calls on workers both within and outside the academy to actively engage in grassroots…

  9. Tipping Point

    Medline Plus

    Full Text Available ... OnSafety CPSC Stands for Safety The Tipping Point Home > 60 Seconds of Safety (Videos) > The Tipping Point ... 24 hours a day. For young children whose home is a playground, it’s the best way to ...

  10. Fixed Points

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 5; Issue 5. Fixed Points - From Russia with Love - A Primer of Fixed Point Theory. A K Vijaykumar. Book Review Volume 5 Issue 5 May 2000 pp 101-102. Fulltext. Click here to view fulltext PDF. Permanent link:

  11. Kinematical Comparison of the 200 m Backstroke Turns between National and Regional Level Swimmers.

    Science.gov (United States)

    Veiga, Santiago; Cala, Antonio; Frutos, Pablo González; Navarro, Enrique

    2013-01-01

    The aims of this investigation were to determine the evolution of selected turn variables during competitive backstroke races and to compare these kinematic variables between two different levels of swimmers. Sixteen national and regional level male swimmers participant in the 200 m backstroke event at the Spanish Swimming Championships in short course (25 m) were selected to analyze their turn performances. The individual distances method with two-dimensional Direct Linear Transformation (2D-DLT) algorithms was used to perform race analyses. National level swimmers presented a shorter "turn time", a longer "distance in", a faster "underwater velocity" and "normalized underwater velocity", and a faster "stroking velocity" than regional level swimmers, whereas no significant differences were detected between levels for the "underwater distance". National level swimmers maintained similar "turn times" over the event and increased "underwater velocity" and "normalized underwater velocity" in the last (seventh) turn segment, whereas regional level swimmers increased "turn time" in the last half of the race. For both national and regional level swimmers, turn "underwater distance" during the last three turns of the race was significantly shorter while no significant differences in distance into the wall occurred throughout the race. The skill level of the swimmers has an impact on the competitive backstroke turn segments. In a 200 m event, the underwater velocity should be maximized to maintain turn proficiency, whereas turn distance must be subordinated to the average velocity. Key PointsThe underwater turn velocity is as a critical variable related to the swimmers' level of skill in a 200 m backstroke event.Best swimmers perform faster but no longer turn segments during a 200 m backstroke event.Best swimmers maintain their turn performance throughout the 200 m backstroke event by increasing the underwater velocity during the final part of the race.The turn distance

  12. METHODICAL MODEL FOR TEACHING BASIC SKI TURN

    Directory of Open Access Journals (Sweden)

    Danijela Kuna

    2013-07-01

    Full Text Available With the aim of forming an expert model of the most important operators for basic ski turn teaching in ski schools, an experiment was conducted on a sample of 20 ski experts from different countries (Croatia, Bosnia and Herzegovina and Slovenia. From the group of the most commonly used operators for teaching basic ski turn the experts picked the 6 most important: uphill turn and jumping into snowplough, basic turn with hand sideways, basic turn with clapping, ski poles in front, ski poles on neck, uphill turn with active ski guiding. Afterwards, ranking and selection of the most efficient operators was carried out. Due to the set aim of research, a Chi square test was used, as well as the differences between frequencies of chosen operators, differences between values of the most important operators and differences between experts due to their nationality. Statistically significant differences were noticed between frequencies of chosen operators (c2= 24.61; p=0.01, while differences between values of the most important operators were not obvious (c2= 1.94; p=0.91. Meanwhile, the differences between experts concerning thier nationality were only noticeable in the expert evaluation of ski poles on neck operator (c2=7.83; p=0.02. Results of current research are reflected in obtaining useful information about methodological priciples of learning basic ski turn organization in ski schools.

  13. Rapid MR assessment of left ventricular systolic function after acute myocardial infarction using single breath-hold cine imaging with the temporal parallel acquisition technique (TPAT) and 4D guide-point modelling analysis of left ventricular function

    International Nuclear Information System (INIS)

    Eberle, Holger C.; Jensen, Christoph J.; Sabin, Georg V.; Naber, Christoph K.; Bruder, Oliver; Nassenstein, Kai; Schlosser, Thomas

    2010-01-01

    We compared four-dimensional guide-point modelling left ventricular function analysis (4DVF) results of cine images in four short-axis and two long-axis slices acquired in a single breath-hold, obtained with the temporal parallel acquisition technique (TPAT), with standard left ventricular function (LVF) analysis results determined by the summation of discs method, in patients who had recently suffered myocardial infarction. Despite wall motion abnormalities, 4DVF yields results for left ventricular ejection fractions and end-diastolic and end-systolic volumes that are in excellent agreement with standard LVF analysis results in these patients. A shortened cardiac magnetic resonance (CMR) protocol using single breath-hold cine image acquisition could facilitate the assessment of left ventricular function soon after myocardial infarction in critically ill patients who are unable to comply with the multiple breath-holds required for standard LVF analysis. (orig.)

  14. 14 CFR 23.203 - Turning flight and accelerated turning stalls.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Turning flight and accelerated turning stalls. 23.203 Section 23.203 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... a 30 degree bank. Reduce speed by steadily and progressively tightening the turn with the elevator...

  15. Advantages of conducting in-situ U-Pb age dating of multiple U-bearing minerals from a single complex: Case in point - the Oka Carbonatite Complex

    Science.gov (United States)

    Chen, W.; Simonetti, A.

    2012-12-01

    sample. The niocalite for a carbonatite sample Oka153 defines a bimodal age distribution, with weighted average 206Pb/238U ages of 110.1 ±5.0 and 133.2 ±6.1 Ma. Apatite from the same sample also records a similar bimodal age distribution of 111.4 ±2.8 and 126.9 ±1.8 Ma. The combined in situ U-Pb dating results for apatite, pervoskite, niocalite from Oka clearly support a protracted history of magmatic activity (~30 Myr) for this carbonatite complex. Of importance, the U-Pb results from this study clearly indicate the significance of conducting a thorough geochronological investigation rather than defining the age of any one alkaline complex solely on the basis of a single radiometric age determination.

  16. Tipping Point

    Medline Plus

    Full Text Available ... Point by CPSC Blogger September 22, 2009 appliance child Childproofing CPSC danger death electrical fall furniture head ... see news reports about horrible accidents involving young children and furniture, appliance and tv tip-overs. The ...

  17. Cellular Reprogramming–Turning the Clock Back

    Indian Academy of Sciences (India)

    Cellular Reprogramming - Turning the Clock Back - Nobel Prize in Physiology or Medicine, 2012. Deepa Subramanyam ... Keywords. Embryonic stem cells; pluripotency; reprogramming; differentiation; Nobel Prize 2012. ... National Centre for Cell Science University of Pune Campus Ganeshkhind Pune 411 007, India.

  18. Turning university professors into competent learners

    NARCIS (Netherlands)

    Stefanova, Eliza; Ilieva, Miroslava; Nikolova, Nikolina; Stefanov, Krassen

    2008-01-01

    Stefanova, E., Ilieva, M., Nikolova, N, & Stefanov, K. (2008). Turning university professors into competent learners. In H. W. Sligte & R. Koper (Eds.), Proceedings of the 4th TENCompetence Open Workshop. Empowering Learners for Lifelong Competence Development: pedagogical, organisational and

  19. Page turning solutions for musicians: a survey.

    Science.gov (United States)

    Wolberg, George; Schipper, Irene

    2012-01-01

    Musicians have long been hampered by the challenge in turning sheet music while their hands are occupied playing an instrument. The sight of a human page turner assisting a pianist during a performance, for instance, is not uncommon. This need for a page turning solution is no less acute during practice sessions, which account for the vast majority of playing time. Despite widespread appreciation of the problem, there have been virtually no robust and affordable products to assist the musician. Recent progress in assistive technology and electronic reading devices offers promising solutions to this long-standing problem. The objective of this paper is to survey the technology landscape and assess the benefits and drawbacks of page turning solutions for musicians. A full range of mechanical and digital page turning products are reviewed.

  20. Conquering the Downwind Turn - SFTE Paper Followup

    National Research Council Canada - National Science Library

    Kolwey, Herman

    2000-01-01

    ...". That's 64 accidents per year to this problem, one piece of which is the turning downwind problem. It also States that: "The way human beings perceive their own movement is fairly well understood". I'm not so sure.

  1. Cellular Reprogramming–Turning the Clock Back

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 18; Issue 6. Cellular Reprogramming - Turning the Clock Back - Nobel Prize in Physiology or Medicine, 2012. Deepa Subramanyam. General Article Volume 18 Issue 6 June 2013 pp 514-521 ...

  2. Turning gene function ON and OFF using sense and antisense photo-morpholinos in zebrafish

    Science.gov (United States)

    Tallafuss, Alexandra; Gibson, Dan; Morcos, Paul; Li, Yongfu; Seredick, Steve; Eisen, Judith; Washbourne, Philip

    2012-01-01

    To understand the molecular mechanisms of development it is essential to be able to turn genes on and off at will and in a spatially restricted fashion. Morpholino oligonucleotides (MOs) are very common tools used in several model organisms with which it is possible to block gene expression. Recently developed photo-activated MOs allow control over the onset of MO activity. However, deactivation of photo-cleavable MO activity has remained elusive. Here, we describe photo-cleavable MOs with which it is possible to activate or de-activate MO function by UV exposure in a temporal and spatial manner. We show, using several different genes as examples, that it is possible to turn gene expression on or off both in the entire zebrafish embryo and in single cells. We use these tools to demonstrate the sufficiency of no tail expression as late as tailbud stage to drive medial precursor cells towards the notochord cell fate. As a broader approach for the use of photo-cleavable MOs, we show temporal control over gal4 function, which has many potential applications in multiple transgenic lines. We demonstrate temporal manipulation of Gal4 transgene expression in only primary motoneurons and not secondary motoneurons, heretofore impossible with conventional transgenic approaches. In another example, we follow and analyze neural crest cells that regained sox10 function after deactivation of a photo-cleavable sox10-MO at different time points. Our results suggest that sox10 function might not be critical during neural crest formation. PMID:22492359

  3. Turning gene function ON and OFF using sense and antisense photo-morpholinos in zebrafish.

    Science.gov (United States)

    Tallafuss, Alexandra; Gibson, Dan; Morcos, Paul; Li, Yongfu; Seredick, Steve; Eisen, Judith; Washbourne, Philip

    2012-05-01

    To understand the molecular mechanisms of development it is essential to be able to turn genes on and off at will and in a spatially restricted fashion. Morpholino oligonucleotides (MOs) are very common tools used in several model organisms with which it is possible to block gene expression. Recently developed photo-activated MOs allow control over the onset of MO activity. However, deactivation of photo-cleavable MO activity has remained elusive. Here, we describe photo-cleavable MOs with which it is possible to activate or de-activate MO function by UV exposure in a temporal and spatial manner. We show, using several different genes as examples, that it is possible to turn gene expression on or off both in the entire zebrafish embryo and in single cells. We use these tools to demonstrate the sufficiency of no tail expression as late as tailbud stage to drive medial precursor cells towards the notochord cell fate. As a broader approach for the use of photo-cleavable MOs, we show temporal control over gal4 function, which has many potential applications in multiple transgenic lines. We demonstrate temporal manipulation of Gal4 transgene expression in only primary motoneurons and not secondary motoneurons, heretofore impossible with conventional transgenic approaches. In another example, we follow and analyze neural crest cells that regained sox10 function after deactivation of a photo-cleavable sox10-MO at different time points. Our results suggest that sox10 function might not be critical during neural crest formation.

  4. Method of Rotational Turning With Multifaceted Cutters

    Science.gov (United States)

    Indakov, N.; Gordeev, Y.; Binchurov, A.

    2016-04-01

    The proposed method combines the elements of skew turning (in which a cut layer moves along the cutting edge) and rotary turning (in which the sections of the cutting edge are constantly renewed). This leads to better cooling and, hence, a longer tool life. The required cutting speed is ensured by selection of the required number of revolutions of the cutter; the rotation of the machined shaft corresponds to the rotary feed.

  5. Derrida’s Turn to Franciscan Philosophy

    Directory of Open Access Journals (Sweden)

    Marko Zlomislic

    2008-12-01

    Full Text Available Contemporary French philosophers such as Levinas, Bataille, and Derrida, along with the existentialists Kierkegaard and Nietzsche have all made use of Franciscan insights in order to safeguard the ipseity that cannot be reduced or totalized. In keeping with the taste that concerns me, this paper will examine Derrida’s turn to the poetry of Gerard Manley Hopkins and how such a turn may place Derrida within a catholic and Franciscan tradition.

  6. Investigación de la unión soldada entre el vástago y las placas de las cuchillas calzadas // Investigation of the welded joint between plates and tipped single-point lathe tools

    Directory of Open Access Journals (Sweden)

    M. Jacas Cabrera

    2000-01-01

    Full Text Available El presente trabajo está dirigido al incremento de los niveles de producción y calidad, específicamente en la línea defabricación de cuchillas calzadas para torno en el centro fabril “Miguel Saavedra” HERRAMIX.En este caso se realizó un análisis para la sustitución de las pastillas de soldar, fabricadas por CIME por nuevastrimetálicas.En el mismo se determinaron los tiempos de calentamiento necesarios para realizar la soldadura, en las máquinas deinducción (TBCHE, así como los valores de resistencia al cizallamiento de los calzos una vez soldados.Palabras claves: Cuchillas de punta, calzos metalo-ceramicos, placas trimetálicas_____________________________________________________________________Abstract:The present work is directed to increase the production and quality levels of tipped single-point lathe tools at “MiguelSaavedra” plant HERRAMIX.This work deals with a study about the substitution of brazing-pads made by CIME for tri-metallic new ones.The induction brazing heating time’s necessaries at induction machines (TBCHE as well as shear-stress values at the tips afterwelding are determined.Key words: tip single point lathe tool, metal ceramic plate, trimetallic pads.

  7. Kinetic analysis of ski turns based on measured ground reaction forces.

    Science.gov (United States)

    Vaverka, Frantisek; Vodickova, Sona; Elfmark, Milan

    2012-02-01

    The objective of this study was to devise a method of kinetic analysis of the ground reaction force that enables the durations and magnitudes of forces acting during the individual phases of ski turns to be described exactly. The method is based on a theoretical analysis of physical forces acting during the ski turn. Two elementary phases were defined: (1) preparing to turn (initiation) and (2) actual turning, during which the center of gravity of the skier-ski system moves along a curvilinear trajectory (steering). The starting point of the turn analysis is a dynamometric record of the resultant acting ground reaction force applied perpendicularly on the ski surface. The method was applied to six expert skiers. They completed a slalom course comprising five gates arranged on the fall line of a 26° slope at a competition speed using symmetrical carving turns (30 evaluated turns). A dynamometric measurement system was placed on the carving skis (168 cm long, radius 16 m, data were recorded at 100 Hz). MATLAB procedures were used to evaluate eight variables during each turn: five time variables and three force variables. Comparison of the turn analysis results between individuals showed that the method is useful for answering various research questions associated with ski turns.

  8. First turn around strategy for RHIC

    International Nuclear Information System (INIS)

    Milutinovic, J.; Ruggiero, A.G.

    1991-01-01

    The authors present a strategy for achieving the so-called first turn around in RHIC. The strategy is based on the same method proposed to correct a distorted closed orbit in RHIC, i.e. on a generalization of the local three-bump method. They found out that the method is very effective in passing the beam through a non-ideal, insufficiently known, machine. The perturbed lattice was generated by the code PATRIS, which was also adapted to control the newly developed software. In ten distributions of errors the software was capable of passing the beam through in 2-3 injection attempts, at full sextupole strength. It was also determined that once the beam makes the first turn around and all the correctors are energized, it stays in the machine for at least several hundred turns

  9. The Opportunities and Threats of Turning Airports into Hubs

    Science.gov (United States)

    Kraus, Andreas; Koch, Benjamin

    2006-01-01

    This paper examines the opportunities and threats which arise when turning origin/destination airports into hubs. The analysis focuses on market development trends, competitive structures, especially in the light of airline network strategies and the growing rivalry between airports, and finally the potential financial impacts for the airport, including both investment efforts and the financial results from hub operations. We argue that in most cases a decision against converting a traditional origin/destination airport into a major transfer point is preferable to the transformation into a hub.

  10. Turning a Poor Ion Channel into a Good Pump

    Science.gov (United States)

    Astumian, Dean

    2003-05-01

    We consider a membrane protein that can exist in two configurations, either one of which acts as a poor ion channel, allowing ions to slowly leak across the membrane from high to low elctrochemical potential. We show that random external fluctuations can provide the energy to turn this poor channel into a good pump that drives ion transport from low to high electrochemical potential. We discuss this result in terms of a gambling analogy, and point to possible implications for fields as far ranging as population biology, economics, and actuarial science.

  11. The embodied turn in research on language and social interaction

    DEFF Research Database (Denmark)

    Nevile, Maurice

    2015-01-01

    I use the term the embodied turn to mean the point when interest in the body became established among researchers on language and social interaction, exploiting the greater ease of video-recording. This review paper tracks the growth of "embodiment" in over 400 papers published in Research...... on Language and Social Interaction from 1987-2013. I consider closely two areas where analysts have confronted challenges, and how they have responded: settling on precise and analytically helpful terminology for the body; and transcribing and representing the body, particularly its temporality and manner....

  12. BP « Deepwater Horizon » du Golfe du Mexique à l’Afrique : un tournant pour l’industrie pétrolière ? BP “Deepwater Horizon” from the Gulf of Mexico to Africa : a turning point for the Oil Industry ?

    Directory of Open Access Journals (Sweden)

    Géraud Magrin

    2010-09-01

    Full Text Available L’explosion de la plateforme BP Deepwater Horizon du 20 avril 2010 constitue une des plus graves pollutions pétrolières de l’histoire. Sa localisation dans les eaux du premier consommateur mondial, et l’implication d’une des compagnies les plus avancées en matière de responsabilité sociale d’entreprise, sont révélatrices des enjeux actuels de la gestion environnementale des risques pétroliers. Alors que les gisements les plus accessibles sont exploités par des sociétés nationales, les compagnies internationales satisfont l’inextinguible demande en pétrole du système mondial en explorant des situations extrêmes, comme les eaux très profondes. Cela s’accompagne de risques croissants. La catastrophe de BP nous montre le danger de considérer un risque infime comme une absence de risque : l’exemption de planification d’urgence explique la longue durée et l’ampleur de la fuite. Elle rappelle aussi que les impacts du pétrole ne sont bien connus qu’à la surface et le long des côtes : or, cette fuite en eaux profondes causera des dommages écologiques graves dans les zones pélagiques. Cet événement changera les règles du jeu de la régulation environnementale pétrolière dans les zones sensibles. Nous donnons un aperçu des évolutions qu’il pourrait favoriser en Afrique, notamment en Mauritanie. Il reste à savoir si l’augmentation des coûts qui en résultera contribuera à accélérer la transition énergétique mondiale hors de la dépendance des hydrocarbures.On Thursday the 20th april 2010, the blowout of the Deepwater Horizon drilling platform operated by BP in the Gulf of Mexico starts what can be considered one of the major oil spills in the world history. Taking place in the national waters of the world’s first oil consumer and affecting one of the more advanced oil major in Corporate Social Responsibility, this accident may turn out to be a land mark for environmental management in the

  13. Leibniz, Lefebvre and the spatial turn in law

    Directory of Open Access Journals (Sweden)

    Isolde de Villiers

    2016-11-01

    Full Text Available This contribution takes as its point of departure the spatial turn in law and the notion of spatial justice. It traces the term ‘spatial justice’ as introduced through the Spatial Planning and Land Use Management Act and it looks at the underlying view of space that has influenced the spatial turn in law. It furthermore investigates the ways in which the spatial turn in law has been influenced by the thinking of Henri Lefebvre, who relies on a Leibnizian conception of space. Lastly the link between Leibniz and legal positivism is considered in order to reach the final conclusion in the form of a caution against merely adding the language of spatial justice to an approach to space that remains caught up in abstract space. This will only further entrench existing fault lines in society. For this conclusion the work of Roger Berkowitz is central. Berkowitz argues convincingly that the work of Leibniz was central in the development of legal positivism, despite Leibniz in general being considered as a natural law thinker. The same applies to spatial justice theory, where the work of Leibniz is central: it may present the possibilities of another law – the law as it ought to be. The law conceptualised as ‘ought’ instead of ‘is’ would promote reconciliation. Alternatively, spatial justice can simply present the law as it ‘is’ and reconfirm and deepen the chasms in our world.

  14. Scalable single point power extraction for compact mobile and stand-alone solar harvesting power sources based on fully printed organic photovoltaic modules and efficient high voltage DC/DC conversion

    DEFF Research Database (Denmark)

    Garcia Valverde, Rafael; Villarejo, José A.; Hösel, Markus

    2015-01-01

    Patterns for fully printed polymer solar cells are presented that inherently enable scaling of the power output with single point electrical energy connection is presented. Connection is made to only one end of the printed foil that can be rolled out for light energy harvesting. The power level...... (AM1.5G, 1000 W m−2). As a demonstration we present a scalable fully integrated and compact power unit for mobile applications comprising solar energy harvesting OPV modules, power conversion and storage. Applications possible include electrical charging of mobile devices, illumination using LED lamps...... takes place in a HVDC–DC converter that is tailored specifically for operation with polymer solar cells by regulation on the input side. The system charges a lithium-polymer battery thus enabling storage of 82 Wh for a printed OPV foil measuring 0.305 m×9 m having a nominal power output of at least 15 W...

  15. Is It Possible to Detect Activated Brown Adipose Tissue in Humans Using Single-Time-Point Infrared Thermography under Thermoneutral Conditions? Impact of BMI and Subcutaneous Adipose Tissue Thickness.

    Science.gov (United States)

    Gatidis, Sergios; Schmidt, Holger; Pfannenberg, Christina A; Nikolaou, Konstantin; Schick, Fritz; Schwenzer, Nina F

    2016-01-01

    To evaluate the feasibility to detect activated brown adipose tissue (BAT) using single-time-point infrared thermography of the supraclavicular skin region under thermoneutral conditions. To this end, infrared thermography was compared with 18-F-FDG PET, the current reference standard for the detection of activated BAT. 120 patients were enrolled in this study. After exclusion of 18 patients, 102 patients (44 female, 58 male, mean age 58±17 years) were included for final analysis. All patients underwent a clinically indicated 18F-FDG-PET/CT examination. Immediately prior to tracer injection skin temperatures of the supraclavicular, presternal and jugular regions were measured using spatially resolved infrared thermography at room temperature. The presence of activated BAT was determined in PET by typical FDG uptake within the supraclavicular adipose tissue compartments. Local thickness of supraclavicular subcutaneous adipose tissue (SCAT) was measured on CT. Measured skin temperatures were statistically correlated with the presence of activated BAT and anthropometric data. Activated BAT was detected in 9 of 102 patients (8.8%). Local skin temperature of the supraclavicular region was significantly higher in individuals with active BAT compared to individuals without active BAT. However, after statistical correction for the influence of BMI, no predictive value of activated BAT on skin temperature of the supraclavicular region could be observed. Supraclavicular skin temperature was significantly negatively correlated with supraclavicular SCAT thickness. We conclude that supraclavicular SCAT thickness influences supraclavicular skin temperature and thus makes a specific detection of activated BAT using single-time-point thermography difficult. Further studies are necessary to evaluate the possibility of BAT detection using alternative thermographic methods, e.g. dynamic thermography or MR-based thermometry taking into account BMI as a confounding factor.

  16. Is It Possible to Detect Activated Brown Adipose Tissue in Humans Using Single-Time-Point Infrared Thermography under Thermoneutral Conditions? Impact of BMI and Subcutaneous Adipose Tissue Thickness.

    Directory of Open Access Journals (Sweden)

    Sergios Gatidis

    Full Text Available To evaluate the feasibility to detect activated brown adipose tissue (BAT using single-time-point infrared thermography of the supraclavicular skin region under thermoneutral conditions. To this end, infrared thermography was compared with 18-F-FDG PET, the current reference standard for the detection of activated BAT.120 patients were enrolled in this study. After exclusion of 18 patients, 102 patients (44 female, 58 male, mean age 58±17 years were included for final analysis. All patients underwent a clinically indicated 18F-FDG-PET/CT examination. Immediately prior to tracer injection skin temperatures of the supraclavicular, presternal and jugular regions were measured using spatially resolved infrared thermography at room temperature. The presence of activated BAT was determined in PET by typical FDG uptake within the supraclavicular adipose tissue compartments. Local thickness of supraclavicular subcutaneous adipose tissue (SCAT was measured on CT. Measured skin temperatures were statistically correlated with the presence of activated BAT and anthropometric data.Activated BAT was detected in 9 of 102 patients (8.8%. Local skin temperature of the supraclavicular region was significantly higher in individuals with active BAT compared to individuals without active BAT. However, after statistical correction for the influence of BMI, no predictive value of activated BAT on skin temperature of the supraclavicular region could be observed. Supraclavicular skin temperature was significantly negatively correlated with supraclavicular SCAT thickness.We conclude that supraclavicular SCAT thickness influences supraclavicular skin temperature and thus makes a specific detection of activated BAT using single-time-point thermography difficult. Further studies are necessary to evaluate the possibility of BAT detection using alternative thermographic methods, e.g. dynamic thermography or MR-based thermometry taking into account BMI as a confounding factor.

  17. Single point mutations in the helicase domain of the NS3 protein enhance dengue virus replicative capacity in human monocyte-derived dendritic cells and circumvent the type I interferon response.

    Science.gov (United States)

    Silveira, G F; Strottmann, D M; de Borba, L; Mansur, D S; Zanchin, N I T; Bordignon, J; dos Santos, C N Duarte

    2016-01-01

    Dengue is the most prevalent arboviral disease worldwide. The outcome of the infection is determined by the interplay of viral and host factors. In the present study, we evaluated the cellular response of human monocyte-derived DCs (mdDCs) infected with recombinant dengue virus type 1 (DV1) strains carrying a single point mutation in the NS3hel protein (L435S or L480S). Both mutated viruses infect and replicate more efficiently and produce more viral progeny in infected mdDCs compared with the parental, non-mutated virus (vBACDV1). Additionally, global gene expression analysis using cDNA microarrays revealed that the mutated DVs induce the up-regulation of the interferon (IFN) signalling and pattern recognition receptor (PRR) canonical pathways in mdDCs. Pronounced production of type I IFN were detected specifically in mdDCs infected with DV1-NS3hel-mutated virus compared with mdDCs infected with the parental virus. In addition, we showed that the type I IFN produced by mdDCs is able to reduce DV1 infection rates, suggesting that cytokine function is effective but not sufficient to mediate viral clearance of DV1-NS3hel-mutated strains. Our results demonstrate that single point mutations in subdomain 2 have important implications for adenosine triphosphatase (ATPase) activity of DV1-NS3hel. Although a direct functional connection between the increased ATPase activity and viral replication still requires further studies, these mutations speed up viral RNA replication and are sufficient to enhance viral replicative capacity in human primary cell infection and circumvent type I IFN activity. This information may have particular relevance for attenuated vaccine protocols designed for DV. © 2015 British Society for Immunology.

  18. Seismic interferometry-turning noise into signal

    NARCIS (Netherlands)

    Curtis, A.; Gerstoft, P.; Sato, H.; Snieder, R.; Wapenaar, C.P.A.

    2006-01-01

    Turning noise into useful data—every geophysicist's dream? And now it seems possible. The field of seismic interferometry has at its foundation a shift in the way we think about the parts of the signal that are currently filtered out of most analyses—complicated seismic codas (the multiply scattered

  19. Business Intelligence: Turning Knowledge into Power

    Science.gov (United States)

    Endsley, Krista

    2009-01-01

    Today, many school districts are turning to business intelligence tools to retrieve, organize, and share knowledge for faster analysis and more effective, guided decision making. Business intelligence (BI) tools are the technologies and applications that gather and report information to help an organization's leaders make better decisions. BI…

  20. Speed docking: reducing truck turn times

    NARCIS (Netherlands)

    Ploos van Amstel, W.

    2013-01-01

    Truck turn times in FMCG supply chain are unreliable. The Dutch ‘Speed Docking’ project in gave clear evidence to this. The result is too many trucks and drivers. FMCG producers, together with logistics service providers and customers, can realise improvements with the use of mobile communication,

  1. The dynamic turn in quantum logic

    NARCIS (Netherlands)

    Baltag, Alexandru; Smets, Sonja

    In this paper we show how ideas coming from two areas of research in logic can reinforce each other. The first such line of inquiry concerns the "dynamic turn" in logic and especially the formalisms inspired by Propositional Dynamic Logic (PDL); while the second line concerns research into the

  2. Strategy in Generative Planning of Turning Processes

    NARCIS (Netherlands)

    van Houten, Frederikus J.A.M.; Kals, H.J.J.

    1986-01-01

    This paper reports on the process and operations planning system ROUND and the strategies which underlie the decision making processes in the planning of turning operations. At first, an outline is given about the environment for which generative systems like ROUND are being developed. The

  3. Silicon Carbide Emitter Turn-Off Thyristor

    Directory of Open Access Journals (Sweden)

    Jun Wang

    2008-01-01

    Full Text Available A novel MOS-controlled SiC thyristor device, the SiC emitter turn-off thyristor (ETO is a promising technology for future high-voltage switching applications because it integrates the excellent current conduction capability of a SiC thyristor with a simple MOS-control interface. Through unity-gain turn-off, the SiC ETO also achieves excellent Safe Operation Area (SOA and faster switching speeds than silicon ETOs. The world's first 4.5-kV SiC ETO prototype shows a forward voltage drop of 4.26 V at 26.5 A/cm2 current density at room and elevated temperatures. Tested in an inductive circuit with a 2.5 kV DC link voltage and a 9.56-A load current, the SiC ETO shows a fast turn-off time of 1.63 microseconds and a low 9.88 mJ turn-off energy. The low switching loss indicates that the SiC ETO could operate at about 4 kHz if 100 W/cm2 conduction and the 100 W/cm2 turn-off losses can be removed by the thermal management system. This frequency capability is about 4 times higher than 4.5-kV-class silicon power devices. The preliminary demonstration shows that the SiC ETO is a promising candidate for high-frequency, high-voltage power conversion applications, and additional developments to optimize the device for higher voltage (>5 kV and higher frequency (10 kHz are needed.

  4. -and -turns in proteins revisited: A new set of amino acid turn ...

    Indian Academy of Sciences (India)

    -turns (7153) and -turns (911) extracted from these proteins were used to derive a revised set of type-dependent amino acid positional preferences and potentials. Compared with previous results, the preference for proline, methionine and tryptophan has increased and the preference for glutamine, valine, glutamic acid ...

  5. Research of remote control system in turn by turn timing system

    International Nuclear Information System (INIS)

    Zhan Zhifeng; Xiao Yanguo; Ma Kui; Yin Zejie; Wu Xiaoyi

    2003-01-01

    In this paper, we introduce a remote control system which is used in a frequency dividing and time-delay module. This control system is based on client/server architecture, and RS232 serial communication protocol. This control system is used in timing system of NSRL turn by turn beam position monitor

  6. Procalcitonin for selecting the antibiotic regimen in outpatients with low-risk community-acquired pneumonia using a rapid point-of-care testing: A single-arm clinical trial

    Science.gov (United States)

    Masiá, Mar; Padilla, Sergio; Ortiz de la Tabla, Victoria; González, Matilde; Bas, Cristina; Gutiérrez, Félix

    2017-01-01

    Objective We aimed to assess the role of procalcitonin (PCT) to guide the initial selection of the antibiotic regimen for low-risk community-acquired pneumonia (CAP). Methods A single-arm clinical trial was conducted including outpatients with CAP and Pneumonia Severity Index risk classes I-II. Antimicrobial selection was based on the results of PCT measured with a rapid point-of-care testing. According to serum PCT levels, patients were assigned to two treatment strategies: oral azithromycin if PCT was Atypical organisms were more common in patients given azithromycin (18.5% vs 8.1%, respectively). The majority (93%) of patients with atypical pneumonia had low PCT levels. Clinical cure rates were 95.8% in the azithromycin group, 94.6% in the levofloxacin group, and 94.4% in the historical control group. No 30-day mortality or recurrences were observed, and the 3-year rates of recurrence and mortality were very low in both groups. Adverse events occurrence was also infrequent. Conclusion A PCT-guided strategy with a rapid point-of-care testing safely allowed selecting empirical narrow-spectrum antibiotics in outpatients with CAP. Trial registration The study is registered with ClinicalTrials.gov, number NCT02600806 PMID:28426811

  7. Efficacy and Safety of Single Botulinum Toxin Type A (Botox®) Injection for Relief of Upper Trapezius Myofascial Trigger Point: A Randomized, Double-Blind, Placebo-Controlled Study.

    Science.gov (United States)

    Kwanchuay, Photsawee; Petchnumsin, Thavatchai; Yiemsiri, Pichet; Pasuk, Nakkamol; Srikanok, Wannarat; Hathaiareerug, Chanasak

    2015-12-01

    Botulinum toxin injection has been applied for pain relief in various chronic pain syndromes. Recently, systematic review studies reported inconclusive effects of Botulinum toxin in myofascial pain management. The present study aimed to demonstrate the efficacy and safety of Botulinum toxin type A (BTxA) (Botox®) injection for pain reduction in myofascial trigger point (MTrP) of the upper trapezius muscle. Thirty-three patients with 48 MTrP on the upper trapezius muscles over three months with moderate to severe pain intensity diagnosed at physical medicine and rehabilitation outpatient department were recruited between December 2011 and March 2012. Eligible patients were blinded and randomly injected with single 0.2 ml (20 IU) of BTxA for 24 MTrP and 0.2 ml of 0.9% NaCl solution for 24 MTrP at the most tender trigger point on the upper trapezius muscle. All patients were advised for stretching exercise and ergonomic adaptation throughout the study. At 3- and 6-week after injections, visual analogue scale (VAS), the pressure pain threshold (PPT), and reported adverse effects were measured. Both BTxA and control groups demonstrated statistically significant differences in VAS reduction and increased PPT after 3 weeks and 6 weeks compared with before treatment. There were no statistically significant differences in VAS reduction from baseline between the two groups at 3- and 6-week after treatment. A statistically significant difference in improvement of PPT from baseline and 6-week after BTxA injection compared with 0.9% NaCl group was shown (1.0 ± 0.9 and 0.5 ± 0.7, p = 0.036). There was mild degree side-effects that spontaneous resolved within one week in both groups without significant difference in percentage. No severe adverse effects were reported during the study. The efficacy in VAS reduction of a single 20 IU of Botulinum toxin type A (Botox®) injection was not different from 0.9% NaCl for myofascial trigger point at the upper trapezius muscle. However

  8. Immediate Effects of Clock-Turn Strategy on the Pattern and Performance of Narrow Turning in Persons With Parkinson Disease.

    Science.gov (United States)

    Yang, Wen-Chieh; Hsu, Wei-Li; Wu, Ruey-Meei; Lin, Kwan-Hwa

    2016-10-01

    Turning difficulty is common in people with Parkinson disease (PD). The clock-turn strategy is a cognitive movement strategy to improve turning performance in people with PD despite its effects are unverified. Therefore, this study aimed to investigate the effects of the clock-turn strategy on the pattern of turning steps, turning performance, and freezing of gait during a narrow turning, and how these effects were influenced by concurrent performance of a cognitive task (dual task). Twenty-five people with PD were randomly assigned to the clock-turn or usual-turn group. Participants performed the Timed Up and Go test with and without concurrent cognitive task during the medication OFF period. The clock-turn group performed the Timed Up and Go test using the clock-turn strategy, whereas participants in the usual-turn group performed in their usual manner. Measurements were taken during the 180° turn of the Timed Up and Go test. The pattern of turning steps was evaluated by step time variability and step time asymmetry. Turning performance was evaluated by turning time and number of turning steps. The number and duration of freezing of gait were calculated by video review. The clock-turn group had lower step time variability and step time asymmetry than the usual-turn group. Furthermore, the clock-turn group turned faster with fewer freezing of gait episodes than the usual-turn group. Dual task increased the step time variability and step time asymmetry in both groups but did not affect turning performance and freezing severity. The clock-turn strategy reduces turning time and freezing of gait during turning, probably by lowering step time variability and asymmetry. Dual task compromises the effects of the clock-turn strategy, suggesting a competition for attentional resources.Video Abstract available for more insights from the authors (see Supplemental Digital Content 1, http://links.lww.com/JNPT/A141).

  9. Bank-to-turn control technology survey for homing missiles

    Science.gov (United States)

    Riedel, F. W.

    1980-01-01

    The potential advantages of bank-to-turn control are summarized. Recent and current programs actively investigating bank-to-turn steering are reviewed and critical technology areas concerned with bank-to-turn control are assessed.

  10. Turning the Appliance Market Around towards A++

    DEFF Research Database (Denmark)

    Nørgaard, Jørgen; Brange, Birgitte; Guldbrandsen, Tom

    2007-01-01

    in the course of a few years. Where models C, D, E earlier dominated the market, the A, A+ and A++, came to dominate as the standard models in stock. Consequently, their prices dropped significantly. The theory of a rational market behavior is based on some assumptions, one being that full information...... energy efficient model within their specification, and 4) in the website are also listed the shops, where consumers can get the appliances at lowest prices. The latter was the most innovative and maybe also the most effective measure in the package. Results showed up as a permanent U-turn of the market...... is available to all actors. The website identifying to the consumers the shops with the lowest priced efficient models was a step in that direction, and the result did not fail to turn up....

  11. Measurement of tool forces in diamond turning

    Energy Technology Data Exchange (ETDEWEB)

    Drescher, J.; Dow, T.A.

    1988-12-01

    A dynamometer has been designed and built to measure forces in diamond turning. The design includes a 3-component, piezoelectric transducer. Initial experiments with this dynamometer system included verification of its predicted dynamic characteristics as well as a detailed study of cutting parameters. Many cutting experiments have been conducted on OFHC Copper and 6061-T6 Aluminum. Tests have involved investigation of velocity effects, and the effects of depth and feedrate on tool forces. Velocity has been determined to have negligible effects between 4 and 21 m/s. Forces generally increase with increasing depth of cut. Increasing feedrate does not necessarily lead to higher forces. Results suggest that a simple model may not be sufficient to describe the forces produced in the diamond turning process.

  12. When attempts at robbing prey turn fatal

    Science.gov (United States)

    Dejean, Alain; Corbara, Bruno; Azémar, Frédéric; Carpenter, James M.

    2012-07-01

    Because group-hunting arboreal ants spread-eagle insect prey for a long time before retrieving them, these prey can be coveted by predatory flying insects. Yet, attempting to rob these prey is risky if the ant species is also an effective predator. Here, we show that trying to rob prey from Azteca andreae workers is a fatal error as 268 out of 276 potential cleptobionts (97.1 %) were captured in turn. The ant workers hunt in a group and use the "Velcro®" principle to cling firmly to the leaves of their host tree, permitting them to capture very large prey. Exceptions were one social wasp, plus some Trigona spp. workers and flies that landed directly on the prey and were able to take off immediately when attacked. We conclude that in this situation, previously captured prey attract potential cleptobionts that are captured in turn in most of the cases.

  13. Abrasive Waterjet (AWJ) Titanium Tangental Turning Evaluation

    Czech Academy of Sciences Publication Activity Database

    Hloch, Sergej; Hlaváček, Petr; Vasilko, K.; Cárach, J.; Samardžič, I.; Kozak, D.; Ščučka, Jiří; Klich, Jiří; Klichová, Dagmar

    2014-01-01

    Roč. 53, č. 4 (2014), s. 537-540 ISSN 0543-5846 R&D Projects: GA MŠk ED2.1.00/03.0082 Institutional support: RVO:68145535 Keywords : titanium * abrasive waterjet turning * traverse speed Subject RIV: JQ - Machines ; Tools Impact factor: 0.959, year: 2014 http://public.carnet.hr/metalurg/Metalurgija/2014_vol_53/No_4/MET_53_4_537-540_Hloch.pdf

  14. Turning customer satisfaction measurements into action

    OpenAIRE

    Lervik-Olsen, Line; Witell, Lars; Gustafsson, Anders

    2014-01-01

    This is the authors’ final, accepted and refereed manuscript to the article. Publisher’s version available at http://dx.doi.org/10.1108/JOSM-01-2014-0025 Purpose – The purpose of this paper is to contribute to the literature on customer orientation by developing and empirically testing a model that attempts to explain the elements that constitute customer orientation and that, in turn, influence customer satisfaction. In particular, this study focuses on how service firms design, ...

  15. FCC-hh turn-around cycle

    CERN Document Server

    Alemany Fernandez, Reyes; Bartmann, Wolfgang; Buffat, Xavier; Niemi, Arto; Schulte, Daniel; Solfaroli Camillocci, Matteo; Stoel, Linda

    2016-01-01

    The turn-around cycle time of a collider is defined as the time spent between the end of stable beams and the start of the next stable beams period, and its calculation is of fundamental importance. On one side it is a crucial ingredient for the computation of the optimal time spent in luminosity production, which defines the integrated luminosity per fill or store. On the other side, combined with the availability and reliability of the machine, it allows to perform a detailed breakdown of the operational performance of the collider over an operational season, i.e. percentage of time in stable beams and beam in the machine with respect to down time. This paper presents a preliminary operational cycle definition for the hadron-hadron Future Circular Collider, as a base line for estimating the corresponding turn-around time. The cycle definition is based on the Large Hadron Collider (LHC) operational cycle. Two turn-around times are presented, the theoretical one and a more realistic one based on the LHC exper...

  16. Beam Optics Measurements Through Turn by Turn Beam Position Data in the SLS

    CERN Document Server

    Zisopoulos, P; Streun, A; Ziemann, v

    2013-01-01

    Refined Fourier analysis of turn-by-turn (TBT) transverse position data measurements can be used for determining several beam properties of a ring, such as transverse tunes, optics functions, phases, chromatic properties and coupling. In particular, the Numerical Analysis of Fundamental Frequencies (NAFF) algorithm is used to analyse TBT data from the Swiss Light Source (SLS) storage ring in order to estimate on and off-momentum beam characteristics. Of particular interest is the potential of using the full position information within one turn in order to measure beam optics properties.

  17. Point nodes persisting far beyond Tc in Bi2212

    Science.gov (United States)

    Kondo, Takeshi; Malaeb, W.; Ishida, Y.; Sasagawa, T.; Sakamoto, H.; Takeuchi, Tsunehiro; Tohyama, T.; Shin, S.

    2015-01-01

    In contrast to a complex feature of antinodal state, suffering from competing orders, the pairing gap of cuprates is obtained in the nodal region, which therefore holds the key to the superconducting mechanism. One of the biggest question is whether the point nodal state as a hallmark of d-wave pairing collapses at Tc like the BCS-type superconductors, or it instead survives above Tc turning into the preformed pair state. A difficulty in this issue comes from the small magnitude of the nodal gap, which has been preventing experimentalists from solving it. Here we use a laser ARPES capable of ultrahigh-energy resolution, and detect the point nodes surviving far beyond Tc in Bi2212. By tracking the temperature evolution of spectra, we reveal that the superconductivity occurs when the pair-breaking rate is suppressed smaller than the single-particle scattering rate on cooling, which governs the value of Tc in cuprates. PMID:26158431

  18. Toward Real-Time Automated Detection of Turns during Gait Using Wearable Inertial Measurement Units

    Directory of Open Access Journals (Sweden)

    Domen Novak

    2014-10-01

    Full Text Available Previous studies have presented algorithms for detection of turns during gait using wearable sensors, but those algorithms were not built for real-time use. This paper therefore investigates the optimal approach for real-time detection of planned turns during gait using wearable inertial measurement units. Several different sensor positions (head, back and legs and three different detection criteria (orientation, angular velocity and both are compared with regard to their ability to correctly detect turn onset. Furthermore, the different sensor positions are compared with regard to their ability to predict the turn direction and amplitude. The evaluation was performed on ten healthy subjects who performed left/right turns at three amplitudes (22, 45 and 90 degrees. Results showed that turn onset can be most accurately detected with sensors on the back and using a combination of orientation and angular velocity. The same setup also gives the best prediction of turn direction and amplitude. Preliminary measurements with a single amputee were also performed and highlighted important differences such as slower turning that need to be taken into account.

  19. MIMIC: An Innovative Methodology for Determining Mobile Laser Scanning System Point Density

    Directory of Open Access Journals (Sweden)

    Conor Cahalane

    2014-08-01

    Full Text Available Understanding how various Mobile Mapping System (MMS laser hardware configurations and operating parameters exercise different influence on point density is important for assessing system performance, which in turn facilitates system design and MMS benchmarking. Point density also influences data processing, as objects that can be recognised using automated algorithms generally require a minimum point density. Although obtaining the necessary point density impacts on hardware costs, survey time and data storage requirements, a method for accurately and rapidly assessing MMS performance is lacking for generic MMSs. We have developed a method for quantifying point clouds collected by an MMS with respect to known objects at specified distances using 3D surface normals, 2D geometric formulae and line drawing algorithms. These algorithms were combined in a system called the Mobile Mapping Point Density Calculator (MIMIC and were validated using point clouds captured by both a single scanner and a dual scanner MMS. Results from MIMIC were promising: when considering the number of scan profiles striking the target, the average error equated to less than 1 point per scan profile. These tests highlight that MIMIC is capable of accurately calculating point density for both single and dual scanner MMSs.

  20. Assessing lexical, syntactic, and conceptual turn-by-turn alignment in conversations involving conflict and deception

    DEFF Research Database (Denmark)

    Duran, Nicholas; Fusaroli, Riccardo; Paxton, Alexandra

    2015-01-01

    -level linguistic alignment, we turn to a unique conversational context: one in which participants disagree or agree with each other about contentious sociopolitical topics, with the added element of one partner secretly taking a "devil's advocate" position. Our findings reveal that high-level intentional factors......Our goal is to present a novel systematic approach for automatically assessing conversational alignment across turn-by-turn exchanges, examining linguistic behavior at increasing levels of abstractness through lexical, syntactic, and conceptual similarity. Using the latest advances in Python......-based NLP tools, the procedure begins by taking conversational partners' turns and converting each into a lemmatized sequence of words, assigning part-of-speech tags and computing high-dimensional semantic vectors per each utterance. Words and part-of-speech tags are further sequenced into n-g! rams...

  1. Modification and Validation of the Triglyceride-to-HDL Cholesterol Ratio as a Surrogate of Insulin Sensitivity in White Juveniles and Adults without Diabetes Mellitus: The Single Point Insulin Sensitivity Estimator (SPISE).

    Science.gov (United States)

    Paulmichl, Katharina; Hatunic, Mensud; Højlund, Kurt; Jotic, Aleksandra; Krebs, Michael; Mitrakou, Asimina; Porcellati, Francesca; Tura, Andrea; Bergsten, Peter; Forslund, Anders; Manell, Hannes; Widhalm, Kurt; Weghuber, Daniel; Anderwald, Christian-Heinz

    2016-09-01

    The triglyceride-to-HDL cholesterol (TG/HDL-C) ratio was introduced as a tool to estimate insulin resistance, because circulating lipid measurements are available in routine settings. Insulin, C-peptide, and free fatty acids are components of other insulin-sensitivity indices but their measurement is expensive. Easier and more affordable tools are of interest for both pediatric and adult patients. Study participants from the Relationship Between Insulin Sensitivity and Cardiovascular Disease [43.9 (8.3) years, n = 1260] as well as the Beta-Cell Function in Juvenile Diabetes and Obesity study cohorts [15 (1.9) years, n = 29] underwent oral-glucose-tolerance tests and euglycemic clamp tests for estimation of whole-body insulin sensitivity and calculation of insulin sensitivity indices. To refine the TG/HDL ratio, mathematical modeling was applied including body mass index (BMI), fasting TG, and HDL cholesterol and compared to the clamp-derived M-value as an estimate of insulin sensitivity. Each modeling result was scored by identifying insulin resistance and correlation coefficient. The Single Point Insulin Sensitivity Estimator (SPISE) was compared to traditional insulin sensitivity indices using area under the ROC curve (aROC) analysis and χ(2) test. The novel formula for SPISE was computed as follows: SPISE = 600 × HDL-C(0.185)/(TG(0.2) × BMI(1.338)), with fasting HDL-C (mg/dL), fasting TG concentrations (mg/dL), and BMI (kg/m(2)). A cutoff value of 6.61 corresponds to an M-value smaller than 4.7 mg · kg(-1) · min(-1) (aROC, M:0.797). SPISE showed a significantly better aROC than the TG/HDL-C ratio. SPISE aROC was comparable to the Matsuda ISI (insulin sensitivity index) and equal to the QUICKI (quantitative insulin sensitivity check index) and HOMA-IR (homeostasis model assessment-insulin resistance) when calculated with M-values. The SPISE seems well suited to surrogate whole-body insulin sensitivity from inexpensive fasting single-point blood draw and BMI

  2. Procalcitonin for selecting the antibiotic regimen in outpatients with low-risk community-acquired pneumonia using a rapid point-of-care testing: A single-arm clinical trial.

    Directory of Open Access Journals (Sweden)

    Mar Masiá

    Full Text Available We aimed to assess the role of procalcitonin (PCT to guide the initial selection of the antibiotic regimen for low-risk community-acquired pneumonia (CAP.A single-arm clinical trial was conducted including outpatients with CAP and Pneumonia Severity Index risk classes I-II. Antimicrobial selection was based on the results of PCT measured with a rapid point-of-care testing. According to serum PCT levels, patients were assigned to two treatment strategies: oral azithromycin if PCT was <0.5 ng/ml, or levofloxacin if levels were ≥0.5 ng/ml. Primary outcome was clinical cure rate. Short-term and long-term outcomes were assessed. Results were compared with those of a historical standard-of-care control-group treated in our centre.Of 253 subjects included, 216 (85.4% were assigned to azithromycin. Pneumococcal infection was diagnosed in 26 (12% and 21 (56.8% patients allocated to azithromycin and levofloxacin groups, respectively. No patients in the azithromycin group developed bacteraemia. Atypical organisms were more common in patients given azithromycin (18.5% vs 8.1%, respectively. The majority (93% of patients with atypical pneumonia had low PCT levels. Clinical cure rates were 95.8% in the azithromycin group, 94.6% in the levofloxacin group, and 94.4% in the historical control group. No 30-day mortality or recurrences were observed, and the 3-year rates of recurrence and mortality were very low in both groups. Adverse events occurrence was also infrequent.A PCT-guided strategy with a rapid point-of-care testing safely allowed selecting empirical narrow-spectrum antibiotics in outpatients with CAP.The study is registered with ClinicalTrials.gov, number NCT02600806.

  3. Turn-by-Turn Analysis of Proton and Gold Beams at Injection in the AGS Booster

    International Nuclear Information System (INIS)

    Gardner, C.; Ahrens, L.; Williams, N.

    1999-01-01

    In this paper the authors describe the latest version of a program they have used for several years to acquire and analyze turn-by-turn data from pick-up electrodes in the AGS Booster during injection. The program determines several parameters of the injected beam including the tunes and the position and angle of the incoming beam. Examples are given for both proton and gold injection

  4. CERN PS Optical Properties Measured with Turn-By-Turn Orbit Data

    CERN Document Server

    Bach, T; Giovannozzi, M; Hernalsteens, C; Lachaize, A; Sterbini, G; Tom´as, R; Wasef, R

    2013-01-01

    The performance of the CERN Proton Synchrotron (PS) has been constantly increasing over the years both in terms of beam parameters (intensity and brightness) and beam manipulations (transverse and longitudinal splitting). This implies a very good knowledge of the linear and non-linear model of the ring. In this paper we report on a detailed campaign of beam measurements based on turn-by-turn orbit data aimed at measuring the optics in several conditions as well as the resonance driving terms.

  5. Hummingbirds control turning velocity using body orientation and turning radius using asymmetrical wingbeat kinematics.

    Science.gov (United States)

    Read, Tyson J G; Segre, Paolo S; Middleton, Kevin M; Altshuler, Douglas L

    2016-03-01

    Turning in flight requires reorientation of force, which birds, bats and insects accomplish either by shifting body position and total force in concert or by using left-right asymmetries in wingbeat kinematics. Although both mechanisms have been observed in multiple species, it is currently unknown how each is used to control changes in trajectory. We addressed this problem by measuring body and wingbeat kinematics as hummingbirds tracked a revolving feeder, and estimating aerodynamic forces using a quasi-steady model. During arcing turns, hummingbirds symmetrically banked the stroke plane of both wings, and the body, into turns, supporting a body-dependent mechanism. However, several wingbeat asymmetries were present during turning, including a higher and flatter outer wingtip path and a lower more deviated inner wingtip path. A quasi-steady analysis of arcing turns performed with different trajectories revealed that changes in radius were associated with asymmetrical kinematics and forces, and changes in velocity were associated with symmetrical kinematics and forces. Collectively, our results indicate that both body-dependent and -independent force orientation mechanisms are available to hummingbirds, and that these kinematic strategies are used to meet the separate aerodynamic challenges posed by changes in velocity and turning radius. © 2016 The Author(s).

  6. Mimicry by asx- and ST-turns of the four main types of β-turn in proteins

    OpenAIRE

    Duddy, William J.; Nissink, J. Willem M.; Allen, Frank H.; Milner-White, E. James

    2004-01-01

    Hydrogen-bonded β-turns in proteins occur in four categories: type I (the most common), type II, type II’, and type I’. Asx-turns resemble β-turns, in that both have an NH. . .OC hydrogen bond forming a ring of 10 atoms. Serine and threonine side chains also commonly form hydrogen-bonded turns, here called ST-turns. Asx-turns and ST-turns can be categorized into four classes, based on side chain rotamers and the conformation of the central turn residue, which are geometrically equivalent to t...

  7. Fluorescence turn on by cholate aggregates.

    Science.gov (United States)

    Baldridge, Anthony; Amador, Adrian; Tolbert, Laren M

    2011-04-05

    Bile salts, including sodium cholate (NaCh), are amphiphilic molecules with a concave hydrophilic side and a convex hydrophobic side. By forming aggregates in aqueous solution, these natural surfactants fulfill vital biological roles in the solubilization of cholesterol, lipids, and fat-soluble vitamins and thus are involved in the transport and absorption of important biological molecules. Following our success with the encapsulation of fluorescent protein chromophore (FP) analogs by synthetic hydrophobic and hydrophilic hosts, based upon substitution patterns, we now report the binding and turn on of other analogs by bile salt aggregates, observations which may lead to new tools for studying trafficking in these important systems.

  8. Brit Crit: Turning Points in British Rock Criticism 1960-1990

    DEFF Research Database (Denmark)

    Gudmundsson, Gestur; Lindberg, U.; Michelsen, M.

    2002-01-01

    The article examines the development of rock criticism in the United Kingdom from the perspective of a Bourdieuan field-analysis. Early British rock critics, like Nik Cohn, were international pioneers, a few years later there was a strong American influence, but British rock criticism has always ...

  9. Turning Points: Using Teachers' Mathematics Life Stories to Understand the Implementation of Mathematics Education Reform

    Science.gov (United States)

    Drake, Corey

    2006-01-01

    In this study, teachers' narrative descriptions of themselves as learners and teachers of mathematics were used to understand teachers' interpretations and implementations of a reform-oriented mathematics curriculum. Twenty elementary school teachers' mathematics life stories were categorized into six types, based on teachers' descriptions of both…

  10. THE SOMALISATION OF POLITICAL ISLAM: TURNING POINT FOR THE CLASH OF ISLAMISMS IN AFRICA

    Directory of Open Access Journals (Sweden)

    Ignacio Gutiérrez de Terán Gómez-Benita

    2011-04-01

    Full Text Available This article covers – firstly and generally speaking – the gradual process of confrontation between traditional African Islam (and particularly the Sufi brotherhoods and the Salafist tendencies that became established in the continent some time ago. Taking the chronic case of Somalia as an example, the author stresses the fact that in addition to doctrinal differences, it is also important to note that social, economic and cultural factors have also helped to aggravate tensions. These, nevertheless, have even erupted in the heart of organisations backing political Islam, in many cases of Wahhabi origin, owing partly to geostrategic determining factors, and partly to the turbulent debate on the advisability of incorporating processes of national reform and reconciliation. Furthermore, and in a way that is reminiscent of a number of antecedents in countries such as Algeria and Afghanistan, the controversy is focused around which strategy to adopt to fight the local leaders who have been labelled as corrupt, and how to link up with the regional and international powers involved in the conflict. Thus, an extreme Somalisation has also reached African Islamist movements, as can be seen in the current fragmentation of Islamism over much of the continent.

  11. EUROPEAN EMISSION TRADING SCHEME AT A TURNING POINT – FROM THE PILOT PHASE TO POST-2012

    Directory of Open Access Journals (Sweden)

    Aura Carmen Slate

    2011-09-01

    Full Text Available Climate change action has become a top priority for the European governments and for the European Union. Since the polluters are part of the energy-intensive industries, the mechanisms designed to reduce greenhouse gas emissions should focus on the economic sector as a primary source of concern. Therefore, environmental issues interrelate with the economic ones and one viable expression of this relation is the EU ETS, a cap-and-trade mechanism. The ETS started with a pilot phase in year 2005 and will continue with a third phase after 2012, period which coincides with the end of Kyoto’s commitment. Although statistical data prove that the EU ETS is becoming more efficient with each phase, in the absence of global involvement the efforts invested in the scheme will be made in vain.

  12. Direct Approaches in L2 Instruction: A Turning Point in Communicative Language Teaching.

    Science.gov (United States)

    Celce-Murcia, Marianne; And Others

    1997-01-01

    Distinguishes two approaches to teaching speaking skills: (1) a "direct approach" in which new linguistic information is practiced explicitly; (2) and an "indirect approach", involving creating situations that lead learners to acquire communicative skills. Argues that a significant shift is occurring in the second approach and raises questions…

  13. Canine viral vaccines at a turning point--a personal perspective.

    Science.gov (United States)

    Carmichael, L E

    1999-01-01

    The most important canine viral infections are distemper and CPV-2. Problems of variable CD vaccine safety and efficacy persist, but CD vaccines have greatly reduced the prevalence of disease and cases in vaccinated dogs are now rare. Canine hepatitis (ICH, CAV-1 infection) also has been controlled well by vaccines for more than 35 years and it is now rare; the sporadic cases seen in the 1990s have usually occurred in unvaccinated dogs. CAV-2 vaccines should, therefore, continue to be given since they have proved to be safe and effective, and prevent hepatitis as well as adenoviral tracheobronchitis. Failure to vaccinate would likely result in increase in cases of ICH, a serious disease, but never as significant as distemper and CPV infection. "Are we vaccinating too often?" The question is complex, but the dominant opinion is "yes" (Smith, 1995). The question cannot be responded to unequivocally, however, since manufacturers employ different strains that vary in their immunizing capacity and, probably, duration of immunity. This question was frequent with distemper in the 1960s. At that time, many veterinarians tested batches of the vaccine they used by providing pre- and postvaccinal sera to competent diagnostic laboratories. That practice appeared to benefit veterinarians and dogs, as well as the quality of vaccines. Unfortunately, many owners and some veterinarians seem to hold the view that infectious diseases such as parvovirus infection can be controlled by frequent vaccination alone. The common practice of dog breeders of vaccinating their animals several times each year is senseless. Revaccination for distemper and parvovirus infection is suggested at 1 year of age, but recommendations regarding the frequency of most vaccinations given after that time are unclear. Since most distemper and CPV-2 vaccines probably provide immunity that endures several years, vaccination at 3- to 5-year intervals, after the first year, seems a reasonable practice until more data on duration of immunity become available. "Are too many kinds of vaccines being promoted for dogs?" Distemper and parvovirus vaccines are essential; canine adenovirus vaccines are recommended since the few cases brought to our attention in recent years have been in unvaccinated dogs. Vaccination against respiratory infections is recommended for most dogs, especially those in kennels, or if they are to be boarded. Need has not been clearly established for coronavirus vaccines; Lyme disease vaccines (see below) are useful in preventing illness in areas where the disease exists, but are unnecessary elsewhere since dogs respond rapidly to appropriate antibiotics; current Leptospira bacterins are without benefit since they contain serovars that fail to protect in most areas (noted below). Lyme disease (LD) was not considered here, but newer recombinant (OspA) vaccines are now available that appear to be safe and effective for at least 1 year and they have not caused vaccine-induced postvaccinal lameness, which has been documented with certain whole-cell Lyme disease bacterins. Lyme disease vaccines should be restricted to dogs in, or entering, endemic areas where infested ticks reside. More than 85% of LD cases occur in the mid-Atlantic and Northeastern States, about 10% in six Midwestern states (Michigan, Minnesota, and Wisconsin), and a smaller percentage in restricted areas of northern California and the Pacific Northwest. Leptospirosis also was not discussed here, but vaccines are commonly reported as a cause of anaphylaxis and current vaccines do not contain the serovars prevalent in most regions. The vast majority of cases diagnosed at the New York State Diagnostic Lab at Cornell are grippotyphosa and pomona serovars and there have been no recent cases caused by canicola or icterohemorrhagiae serovars. Because leptospirosis is an important disease of dogs, there is an urgent need for more research and the development of safer vaccines that contain the prevalent

  14. Interactive Micro-Processes in Classroom Discourse: Turning Points and Emergent Meanings

    Science.gov (United States)

    Mameli, Consuelo; Molinari, Luisa

    2013-01-01

    Based on a qualitative analysis of classroom discourse in Italian primary schools, this paper analyses the micro-processes that are emergent moment-by-moment in the unfolding interactions between teacher and pupils. More in particular, our purpose is to identify the conditions under which the interactive orientation of a sequence changes. We argue…

  15. Turning Points in the Lives of Chinese and Indian Women Leaders Working toward Social Justice

    Directory of Open Access Journals (Sweden)

    Rosanna Hertz

    2016-10-01

    Full Text Available Institutional change has a human face. This paper explores how a select group of women in China and India experienced economic and political turmoil and why they chose to become change agents. Through in-depth interviews with 40 women from NGOs, government agencies and private business, four broad moments in the evolution of a change agent are identified and discussed: (1 awareness of a double-bind; (2 reframing the tension induced by that double-bind; (3 becoming an agent of change; and (4 building a vibrant network. To highlight these key features, four women’s narratives are discussed in greater depth from recognizing injustice to taking a non-traditional stand. The paper concludes with a call for further comparative work on the role of personal narratives in shaping a movement for change.

  16. Educational Turning Point in Albania: No More Mechanic Parrots but Critical Thinkers

    Science.gov (United States)

    Alhasani, Mirela Dubali

    2015-01-01

    Since 2004 Albanian academics have been making efforts to establish the best Western practices of academic writing associated with critical thinking and writing skills for university students. In this article, I will shed light upon the special challenges and peculiarities the establishment of Academic Writing discipline has encountered in Albania…

  17. The 2015 Paris Climate Conference: A turning point in the world's energy history

    Science.gov (United States)

    Klimenko, V. V.; Mikushina, O. V.; Tereshin, A. G.

    2016-06-01

    It has been established that the consistent implementation of the 2015 Paris Climate Conference implies the quick retire of coal from the global energy balance and its replacement with the energy from unconventional and renewable sources. It is shown that even the full-scale implementation of the agreement will not keep global warming within 2°C.

  18. The still point of the turning world? Building on Balint: A personal view.

    Science.gov (United States)

    Elder, Andrew

    2015-01-01

    In this article, I will respond to the conference title "Building on Balint" by briefly considering some of the inherent obstacles to Balint work, before describing the current state of play in the UK. I will argue that Balint work might benefit from exploring its relationship with attachment theory more fully. In particular, I emphasize an important new role for Balint groups within contemporary health-care organizations-one that enhances a feeling of emotional security for the professional within the organization and also benefits the teamwork and morale of the organization itself. I will give an example of a Balint group in a health-care organization for vulnerable doctors and finish by giving a report on the development of Balint groups for medical students in the UK. © The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  19. Autobiographical Memory and Depression in the Later Age: The Bump Is a Turning Point

    Science.gov (United States)

    Gidron, Yori; Alon, Shirly

    2007-01-01

    This preliminary study integrated previous findings of the distribution of autobiographical memories in the later age according to their age of occurrence, with the overgeneral memory bias predictive of depression. Twenty-five non-demented, Israeli participants between 65-89 years of age provided autobiographical memories to 4 groups of word cues…

  20. ROK-U.S. Security Relations: The China Factor and a Turning Point

    National Research Council Canada - National Science Library

    Kim, Sung

    2002-01-01

    ... to maintaining a tight alliance relationship between Seoul and Washington during the Cold War era, the recently increasing importance of China in South Korea's strategic calculations has become a major...

  1. The Campaign of 1777: Examination of a Turning Point Using DIME

    Science.gov (United States)

    2009-12-11

    databases /efts/AmArch/IMAGE/.1072 (accessed November 2, 2009). 15 Continental Congress, “Declaration and Resolves of the First Continental Congress, October...http://colet.uchicago.edu/cgi-bin/amarch/getdoc.pl?/ projects/artflb/ databases /efts/AmArch/IMAGE/.1072 (accessed November 2, 2009). Continental...The Historical Journal 22, no. 1 (March 1979): 75-91. JSTOR Publications. http://www.jstor.org/stable/ 2639012 (accessed November 13, 2009). Gasset

  2. Turning Point: Operation Allied Force and the Allure of Air Power

    Science.gov (United States)

    2014-06-13

    Air Force Base in Nevada, from “a windowless bunker, lit by constantly flickering computer screens,” a Predator drone operator zoomed in on the...from the air 20 campaign.19 These imaging systems were susceptible to being fooled by Iraq’s use of decoys, camouflage , and digging in of forces...as the barrel of artillery tubes.331 Flying at 15,000 feet, pilots could not tell the difference. Camouflage also hindered air efforts. Many U.S

  3. Stressors and Turning Points in High School and Dropout: A Stress Process, Life Course Framework

    Science.gov (United States)

    Dupéré, Véronique; Leventhal, Tama; Dion, Eric; Crosnoe, Robert; Archambault, Isabelle; Janosz, Michel

    2015-01-01

    High school dropout is commonly seen as the result of a long-term process of failure and disengagement. As useful as it is, this view has obscured the heterogeneity of pathways leading to dropout. Research suggests, for instance, that some students leave school not as a result of protracted difficulties but in response to situations that emerge…

  4. Turning Points in Qualitative Research: Tying Knots in a Handkerchief. Crossroads in Qualitative Inquiry Series.

    Science.gov (United States)

    Lincoln, Yvonna S., Ed.; Denzin, Norman K., Ed.

    The chapters of this volume traces the changes in the discipline of qualitative inquiry over the last five decades. The collection serves as a textbook for training scholars in the history and trajectory of qualitative research. The chapters of part 1, The Revolution of Representation: Feminist and Race/Ethnic Studies Discourses, are: (1) Situated…

  5. Fashoda: Turning Point in Anglo-French Relations: a Study in Military-Political Affairs.

    Science.gov (United States)

    1976-01-01

    Ministere des Affaires Etrang~res, Documents diplomrtiques frangais, 1871-1914 (1st series, 16 volumes, Paris: amprimerin N tioial , 1929-59), XII, no. 152...Minister of Finance Paul Peytral Minister of Foreign Affairs Th~ophile Delcasse Minister of Justice M. Lebret Minister of War Charles-Louis de Freycinet...Michel’s La Mission Marchand is a precise examination of the financing , orga- nization, and support of the Marchand Expedition, as well as its progress, mile

  6. Hatchability of chicken eggs as influenced by turning frequency in ...

    African Journals Online (AJOL)

    An experiment was conducted to determine the influence of turning frequency of chicken eggs on hatchability in hurricane lantern incubator. There were four treatments in which eggs were not turned in treatment one (control), those in treatment two were turned once daily (morning), treatment three turned twice daily ...

  7. Document turn-over analysis to determine need of NPP construction in build-up structures of reinforced concrete

    International Nuclear Information System (INIS)

    Vojpe, D.K.; Lyubavin, V.K.

    1986-01-01

    Document turn-over to determine used of NPP construction in build-up structures of reinforced concrete is carried out. Ways of improving determination of needs of NPP construction board in the mentioned structures are pointed out

  8. Existence of quasi-stationary neutron and x-ray states near the surface of a deformed single crystal

    CERN Document Server

    Iolin, E

    1999-01-01

    The problem of x-ray or neutron multiply internally reflected inside a bent single crystal plate (Bragg geometry) is considered. It is found that such multiple reflections lead to the existence of quasi-stationary (QS) states. QS states are discrete and correspond to the resonance of motion of the tie point between the front surface and a 'turning place' inside a single crystal. (author)

  9. The management of turn transition in signed interaction through the lens of overlaps

    Directory of Open Access Journals (Sweden)

    Simone eGirard-Groeber

    2015-06-01

    Full Text Available There have been relatively few studies on sign language interaction carried out within the framework of conversation analysis (CA. Therefore, questions remain open about how the basic building blocks of social interaction such as turn, turn construction unit (TCU and turn transition relevance place (TRP can be understood and analysed in sign language interaction. Recent studies have shown that signers regularly fine-tune their turn-beginnings to potential completion points of turns (De Vos, Torreira & Levinson, 2015; Groeber, 2014; Groeber & Pochon-Berger, 2014. Moreover, signers deploy practices for overlap resolution as in spoken interaction (McCleary & Leite, 2013. While these studies have highlighted the signers’ orientation to the ‘one-at-a-time’ principle described by Sacks et al., (1974, the present article adds to this line of research by investigating in more detail those sequential environments where overlaps occur. The contribution provides an overview of different types of overlap with a focus of the overlap’s onset with regard to a current signer’s turn. On the basis of a 33-minute video-recording of a multi-party interaction between 4 female signers in Swiss German Sign Language (DSGS, the paper provides evidence for the orderliness of overlapping signing. Furthermore, the contribution demonstrates how participants collaborate in the situated construction of turns as a dynamic and emergent gestalt and how they interactionally achieve turn transition. Thereby the study adds to recent research in spoken and in signed interaction that proposes to rethink turn boundaries and turn transition as flexible and interactionally achieved.

  10. Analysis of forces in ultrasonically assisted turning

    Science.gov (United States)

    Ahmed, N.; Mitrofanov, A. V.; Babitsky, V. I.; Silberschmidt, V. V.

    2007-12-01

    Many modern engineering materials are very difficult to process with conventional machining methods. Ultrasonically assisted turning (UAT) is a new technology, where high frequency vibration (frequency f≈20 kHz, amplitude a≈15 μm) is superimposed on the movement of the cutting tool. Compared to conventional turning (CT), UAT allows significant improvements in processing many intractable materials, such as high-strength aerospace alloys and composites, by producing a noticeable decrease in cutting forces and a superior surface finish. Vibro-impact interaction between the tool and workpiece in UAT during the chip formation leads to a dynamically changing cutting force in the process zone as compared to the quasistatic one in CT. The paper presents an experimental study and computational (finite-element) model of both CT and UAT. Forces acting on the cutting tool in UAT are studied, and their dependence on vibration amplitude, frequency and vibration direction as well as on cutting parameters, such as feed rate and cutting speed, are investigated.

  11. Development of a Low Cost MQL Setup for Turning Operations

    Directory of Open Access Journals (Sweden)

    Islam Sumaiya

    2017-01-01

    Full Text Available In this study, the effect of MQL application on the tool wear, surface roughness and chip formation in turning Aluminum alloy 6061 is investigated. Experiments were carried out by plain turning of an Aluminum bar with varying depth of cut, cutting speeds (spindle speed and cutting environments (Dry, Wet and MQL. A newly designed, cost efficient and portable MQL setup was developed for this study. For each experimental trial, five passes were carried out in order to promote the formation of tool wear. After each pass, the tool surface was examined under a microscope and the surface roughness was measured using a stylus based surface tester. The extent of tool wear from each pass is measured by using ImageJ software. Chips were collected after the five passes and were physically examined. The newly designed MQL delivery system was successful in delivering a fine mist of lubricant at the cutting point. MQL lubrication provided lower surface roughness and tool wear values compared to wet and dry conditions due to effective temperature reduction and improved lubrication penetration of cutting zones, as well as better chip flushing. Chip formed under MQL conditions had reduced chip thickness due to reduced temperatures. MQL was found to have the greatest positive impact on tool wear and surface roughness parameters based on ANOVA results.

  12. Quantum fluctuations and coherence in high-precision single-electron capture.

    Science.gov (United States)

    Kashcheyevs, Vyacheslavs; Timoshenko, Janis

    2012-11-21

    The phase of a single quantum state is undefined unless the history of its creation provides a reference point. Thus, quantum interference may seem hardly relevant for the design of deterministic single-electron sources which strive to isolate individual charge carriers quickly and completely. We provide a counterexample by analyzing the nonadiabatic separation of a localized quantum state from a Fermi sea due to a closing tunnel barrier. We identify the relevant energy scales and suggest ways to separate the contributions of quantum nonadiabatic excitation and back tunneling to the rare noncapture events. In the optimal regime of balanced decay and nonadiabaticity, our simple electron trap turns into a single-lead Landau-Zener back tunneling interferometer, revealing the dynamical phase accumulated between the particle capture and leakage. The predicted "quantum beats in back tunneling" may turn the error of a single-electron source into a valuable signal revealing essentially nonadiabatic energy scales of a dynamic quantum dot.

  13. The performance of stroke survivors in turning-while-walking while carrying out a concurrent cognitive task compared with controls.

    Directory of Open Access Journals (Sweden)

    Wing-Nga Chan

    Full Text Available Turning-while-walking is one of the commonest causes of falls in stroke survivors. It involves cognitive processing and may be challenging when performed concurrently with a cognitive task. Previous studies of dual-tasking involving turning-while-walking in stroke survivors show that the performance of physical tasks is compromised. However, the design of those studies did not address the response of stroke survivors under dual-tasking condition without specifying the task-preference and its effect on the performance of the cognitive task.First, to compare the performance of single-tasking and dual-tasking in stroke survivors. Second, to compare the performance of stroke survivors with non-stroke controls.Fifty-nine stroke survivors and 45 controls were assessed with an auditory Stroop test, a turning-while-walking test, and a combination of the two single tasks. The outcome of the cognitive task was measured by the reaction time and accuracy of the task. The physical task was evaluated by measuring the turning duration, number of steps to turn, and time to complete the turning-while-walking test.Stroke survivors showed a significantly reduced accuracy in the auditory Stroop test when dual-tasking, but there was no change in the reaction time. Their performance in the turning-while-walking task was similar under both single-tasking and dual-tasking condition. Additionally, stroke survivors demonstrated a significantly longer reaction time and lower accuracy than the controls both when single-tasking and dual-tasking. They took longer to turn, with more steps, and needed more time to complete the turning-while-walking task in both tasking conditions.The results show that stroke survivors with high mobility function performed the auditory Stroop test less accurately while preserving simultaneous turning-while-walking performance. They also demonstrated poorer performance in both single-tasking and dual-tasking as compared with controls.

  14. Hard turning micro-machine tool

    Science.gov (United States)

    DeVor, Richard E; Adair, Kurt; Kapoor, Shiv G

    2013-10-22

    A micro-scale apparatus for supporting a tool for hard turning comprises a base, a pivot coupled to the base, an actuator coupled to the base, and at least one member coupled to the actuator at one end and rotatably coupled to the pivot at another end. A tool mount is disposed on the at least one member. The at least one member defines a first lever arm between the pivot and the tool mount, and a second lever arm between the pivot and the actuator. The first lever arm has a length that is less than a length of the second lever arm. The actuator moves the tool mount along an arc.

  15. Turned Back: Mad Men as Intermedial Melodrama

    Directory of Open Access Journals (Sweden)

    Monique Rooney

    2012-09-01

    Full Text Available This essay draws on definitions of gesture (Giorgio Agamben and Peter Brooks and catachresis (Peter Brooks, Jacques Derrida to examine the primacy of non-verbal signifiers as communicators of meaning in AMC’s Mad Men. Beginning with an analysis of Mad Men’s credit sequence, it draws attention to Mad Men’s use of gesture and catachresis in relation to melodrama’s privileging of non-verbal and naturalistic expression and its persistence as an intermedial mode that has moved back and forth between various media (theatre, novel, cinema, television and now digital formats. It argues that Mad Men’s melodramatic aesthetic is one that obliquely, and via a gestural and rhetorical ‘turned back’, communicates its relation to the past and the present.

  16. Autism genes keep turning up chromatin.

    Science.gov (United States)

    Lasalle, Janine M

    2013-06-19

    Autism-spectrum disorders (ASD) are complex genetic disorders collectively characterized by impaired social interactions and language as well as repetitive and restrictive behaviors. Of the hundreds of genes implicated in ASD, those encoding proteins acting at neuronal synapses have been most characterized by candidate gene studies. However, recent unbiased genome-wide analyses have turned up a multitude of novel candidate genes encoding nuclear factors implicated in chromatin remodeling, histone demethylation, histone variants, and the recognition of DNA methylation. Furthermore, the chromatin landscape of the human genome has been shown to influence the location of de novo mutations observed in ASD as well as the landscape of DNA methylation underlying neurodevelopmental and synaptic processes. Understanding the interactions of nuclear chromatin proteins and DNA with signal transduction pathways and environmental influences in the developing brain will be critical to understanding the relevance of these ASD candidate genes and continued uncovering of the "roots" of autism etiology.

  17. Introduction: The Participatory Turn in Urbanism

    Directory of Open Access Journals (Sweden)

    Maroš Krivý

    2014-08-01

    Full Text Available This issue of Footprint examines the recent participatory turn in urban planning and urban design. It discusses the co-opting of participatory processes by planning departments, the systematic disregard of inequalities, and the empowering of the market resulting from the ‘anti-statism’ present in many participatory schemes.What is the relationship between the institutionalisation of participation and the practices of autonomy, self-organisation, and inclusion? When and how does genuine empowerment of collectives take place? Does the demand for the empowerment of local organisations and communities strengthen the market forces at the expense of central government?This issue attempts to problematise ‘participation’, to call attentions to some of its shortcomings, deficits, and limitations, not in order to necessarily bypass the demand for the democratisation of the urban, but in order to rectify and strengthen it.

  18. The experience turn as ‘bandwagon’

    DEFF Research Database (Denmark)

    Fuglsang, Lars; Eide, Dorthe

    2013-01-01

    further central processes, namely appropriation and narrowing the workspace. One Norwegian and one Danish network are studied using a case methodology. They are two rural networks of mainly small tourism firms. The empirical study confirms and illustrates how the bandwagon effect involves these three core......This paper uses the bandwagon metaphor to analyse, in two rural contexts, how small tourism firms become engaged in the idea of the experience economy and how the idea is turned into practice through network formation and innovation. In developing a practice-based approach we use the bandwagon...... metaphor to conceptualize network formation and innovation in terms of a ‘journey’. Following the practice-based literature on bandwagons, the journey starts by labelling an idea that is broad enough to give meaning to, and pull together, a number of diverse supporters. The journey also depends on two...

  19. Turning Video Resource Management into Cloud Computing

    Directory of Open Access Journals (Sweden)

    Weili Kou

    2016-07-01

    Full Text Available Big data makes cloud computing more and more popular in various fields. Video resources are very useful and important to education, security monitoring, and so on. However, issues of their huge volumes, complex data types, inefficient processing performance, weak security, and long times for loading pose challenges in video resource management. The Hadoop Distributed File System (HDFS is an open-source framework, which can provide cloud-based platforms and presents an opportunity for solving these problems. This paper presents video resource management architecture based on HDFS to provide a uniform framework and a five-layer model for standardizing the current various algorithms and applications. The architecture, basic model, and key algorithms are designed for turning video resources into a cloud computing environment. The design was tested by establishing a simulation system prototype.

  20. Exact 2-point function in Hermitian matrix model

    International Nuclear Information System (INIS)

    Morozov, A.; Shakirov, Sh.

    2009-01-01

    J. Harer and D. Zagier have found a strikingly simple generating function [1,2] for exact (all-genera) 1-point correlators in the Gaussian Hermitian matrix model. In this paper we generalize their result to 2-point correlators, using Toda integrability of the model. Remarkably, this exact 2-point correlation function turns out to be an elementary function - arctangent. Relation to the standard 2-point resolvents is pointed out. Some attempts of generalization to 3-point and higher functions are described.

  1. Single gaze gestures

    DEFF Research Database (Denmark)

    Møllenbach, Emilie; Lilholm, Martin; Gail, Alastair

    2010-01-01

    This paper examines gaze gestures and their applicability as a generic selection method for gaze-only controlled interfaces. The method explored here is the Single Gaze Gesture (SGG), i.e. gestures consisting of a single point-to-point eye movement. Horizontal and vertical, long and short SGGs were...

  2. Turning to Ontology in STS? Turning to STS through ‘Ontology’

    NARCIS (Netherlands)

    van Heur, B.; Leydesdorff, L.; Wyatt, S.

    2012-01-01

    We examine the evidence for the claim of an ‘ontological turn’ in science and technology studies (STS). Despite an increase in references to ‘ontology’ in STS since 1989, we show that there has not so much been an ontological turn as multiple discussions deploying the language of ontology,

  3. A time-motion analysis of turns performed by highly ranked viennese waltz dancers.

    Science.gov (United States)

    Prosen, Jerneja; James, Nic; Dimitriou, Lygeri; Perš, Janez; Vučković, Goran

    2013-01-01

    Twenty-four dance couples performing at the 2011 IDSF (International DanceSport Federation) International Slovenia Open were divided into two groups: the first twelve placed couples (top ranked) and the last twelve placed couples (lower ranked). Video recordings were processed automatically using computer vision tracking algorithms under operator supervision to calculate movement parameters. Time and speed of movement were analysed during single natural (right) and reverse (left) turns performed during the Viennese waltz. Both top and lower ranked dancers tended to perform similar proportionate frequencies of reverse (≈ 35%) and natural (≈ 65%) turns. Analysis of reverse turns showed that the top ranked dancers performed less turns on a curved trajectory (16%) than the lower ranked dancers (33%). The top ranked couples performed all turns at similar speeds (F = 1.31, df = 3, p = 0.27; mean = 2.09m/s) all of which were significantly quicker than the lower ranked couples (mean = 1.94m/s), the greatest differences found for reverse turns (12.43% faster for curved trajectories, 8.42% for straight trajectories). This suggests that the ability to maintain a high speed in the more difficult turns, particularly the reverse turns on a curved trajectory, results in the overall dance appearing more fluent as the speed of movement does not fluctuate as much. This aspect of performance needs to be improved by lower ranked dancers if they wish to improve rating of their performance. Future research should determine which factors relate to the speed of turns.

  4. Europe joins the race to turn the Internet into one vast computer

    CERN Multimedia

    Butler, D

    2000-01-01

    CERN is coordinating an European proposal to design internet and software protocols to turn the internet into a single gigantic computer - a 'grid'. The impetus has come from the challenges surrounding the analysis of the vast amounts of data which will be generated by the LHC (1 page).

  5. A Logical OR Redundancy within the Asx-Pro-Asx-Gly Type 1 {Beta}-Turn Motif

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jihun; Dubey, Vikash Kumar; Longo, Lian M.; Blaber, Michael (FSU)

    2008-04-19

    Turn secondary structure is essential to the formation of globular protein architecture. Turn structures are, however, much more complex than either {alpha}-helix or {beta}-sheet, and the thermodynamics and folding kinetics are poorly understood. Type I {beta}-turns are the most common type of reverse turn, and they exhibit a statistical consensus sequence of Asx-Pro-Asx-Gly (where Asx is Asp or Asn). A comprehensive series of individual and combined Asx mutations has been constructed within three separate type I 3:5 G1 bulge {beta}-turns in human fibroblast growth factor-1, and their effects on structure, stability, and folding have been determined. The results show a fundamental logical OR relationship between the Asx residues in the motif, involving H-bond interactions with main-chain amides within the turn. These interactions can be modulated by additional interactions with residues adjacent to the turn at positions i + 4 and i + 6. The results show that the Asx residues in the turn motif make a substantial contribution to the overall stability of the protein, and the Asx logical OR relationship defines a redundant system that can compensate for deleterious point mutations. The results also show that the stability of the turn is unlikely to be the prime determinant of formation of turn structure in the folding transition state.

  6. A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif.

    Science.gov (United States)

    Lee, Jihun; Dubey, Vikash Kumar; Longo, Liam M; Blaber, Michael

    2008-04-04

    Turn secondary structure is essential to the formation of globular protein architecture. Turn structures are, however, much more complex than either alpha-helix or beta-sheet, and the thermodynamics and folding kinetics are poorly understood. Type I beta-turns are the most common type of reverse turn, and they exhibit a statistical consensus sequence of Asx-Pro-Asx-Gly (where Asx is Asp or Asn). A comprehensive series of individual and combined Asx mutations has been constructed within three separate type I 3:5 G1 bulge beta-turns in human fibroblast growth factor-1, and their effects on structure, stability, and folding have been determined. The results show a fundamental logical OR relationship between the Asx residues in the motif, involving H-bond interactions with main-chain amides within the turn. These interactions can be modulated by additional interactions with residues adjacent to the turn at positions i+4 and i+6. The results show that the Asx residues in the turn motif make a substantial contribution to the overall stability of the protein, and the Asx logical OR relationship defines a redundant system that can compensate for deleterious point mutations. The results also show that the stability of the turn is unlikely to be the prime determinant of formation of turn structure in the folding transition state.

  7. A Logical OR Redundancy Within the Asx-Pro-Asx-Gly Type I beta-Turn Motif

    Energy Technology Data Exchange (ETDEWEB)

    Lee,J.; Dubey, V.; Longo, L.; Blaber, M.

    2008-01-01

    Turn secondary structure is essential to the formation of globular protein architecture. Turn structures are, however, much more complex than either ?-helix or ?-sheet, and the thermodynamics and folding kinetics are poorly understood. Type I ?-turns are the most common type of reverse turn, and they exhibit a statistical consensus sequence of Asx-Pro-Asx-Gly (where Asx is Asp or Asn). A comprehensive series of individual and combined Asx mutations has been constructed within three separate type I 3:5 G1 bulge ?-turns in human fibroblast growth factor-1, and their effects on structure, stability, and folding have been determined. The results show a fundamental logical OR relationship between the Asx residues in the motif, involving H-bond interactions with main-chain amides within the turn. These interactions can be modulated by additional interactions with residues adjacent to the turn at positions i + 4 and i + 6. The results show that the Asx residues in the turn motif make a substantial contribution to the overall stability of the protein, and the Asx logical OR relationship defines a redundant system that can compensate for deleterious point mutations. The results also show that the stability of the turn is unlikely to be the prime determinant of formation of turn structure in the folding transition state.

  8. Mimicry by asx- and ST-turns of the four main types of beta-turn in proteins.

    Science.gov (United States)

    Duddy, William J; Nissink, J Willem M; Allen, Frank H; Milner-White, E James

    2004-11-01

    Hydrogen-bonded beta-turns in proteins occur in four categories: type I (the most common), type II, type II', and type I'. Asx-turns resemble beta-turns, in that both have an NH. . .OC hydrogen bond forming a ring of 10 atoms. Serine and threonine side chains also commonly form hydrogen-bonded turns, here called ST-turns. Asx-turns and ST-turns can be categorized into four classes, based on side chain rotamers and the conformation of the central turn residue, which are geometrically equivalent to the four types of beta-turns. We propose asx- and ST-turns be named using the type I, II, I', and II' beta-turn nomenclature. Using this, the frequency of occurrence of both asx- and ST-turns is: type II' > type I > type II > type I', whereas for beta-turns it is type I > type II > type I' > type II'. Almost all type II asx-turns occur as a recently described three residue feature named an asx-nest.

  9. Mimicry by asx- and ST-turns of the four main types of β-turn in proteins

    Science.gov (United States)

    Duddy, William J.; Nissink, J. Willem M.; Allen, Frank H.; Milner-White, E. James

    2004-01-01

    Hydrogen-bonded β-turns in proteins occur in four categories: type I (the most common), type II, type II’, and type I’. Asx-turns resemble β-turns, in that both have an NH. . .OC hydrogen bond forming a ring of 10 atoms. Serine and threonine side chains also commonly form hydrogen-bonded turns, here called ST-turns. Asx-turns and ST-turns can be categorized into four classes, based on side chain rotamers and the conformation of the central turn residue, which are geometrically equivalent to the four types of β-turns. We propose asx- and ST-turns be named using the type I, II, I’, and II’ β-turn nomenclature. Using this, the frequency of occurrence of both asx- and ST-turns is: type II’ > type I > type II > type I’, whereas for β-turns it is type I > type II > type I’ > type II’. Almost all type II asx-turns occur as a recently described three residue feature named an asx-nest. PMID:15459339

  10. Predicting turns in proteins with a unified model.

    Directory of Open Access Journals (Sweden)

    Qi Song

    Full Text Available MOTIVATION: Turns are a critical element of the structure of a protein; turns play a crucial role in loops, folds, and interactions. Current prediction methods are well developed for the prediction of individual turn types, including α-turn, β-turn, and γ-turn, etc. However, for further protein structure and function prediction it is necessary to develop a uniform model that can accurately predict all types of turns simultaneously. RESULTS: In this study, we present a novel approach, TurnP, which offers the ability to investigate all the turns in a protein based on a unified model. The main characteristics of TurnP are: (i using newly exploited features of structural evolution information (secondary structure and shape string of protein based on structure homologies, (ii considering all types of turns in a unified model, and (iii practical capability of accurate prediction of all turns simultaneously for a query. TurnP utilizes predicted secondary structures and predicted shape strings, both of which have greater accuracy, based on innovative technologies which were both developed by our group. Then, sequence and structural evolution features, which are profile of sequence, profile of secondary structures and profile of shape strings are generated by sequence and structure alignment. When TurnP was validated on a non-redundant dataset (4,107 entries by five-fold cross-validation, we achieved an accuracy of 88.8% and a sensitivity of 71.8%, which exceeded the most state-of-the-art predictors of certain type of turn. Newly determined sequences, the EVA and CASP9 datasets were used as independent tests and the results we achieved were outstanding for turn predictions and confirmed the good performance of TurnP for practical applications.

  11. THE NEOLIBERAL TURN IN AMERICAN HEALTH CARE.

    Science.gov (United States)

    Gaffney, Adam

    2015-01-01

    Leaving millions both uninsured and underinsured, the Affordable Care Act does not create a system of universal health care in the United States. To understand its shortcomings, we have to understand it as part of a historic shift in the political economy of American health care. This "neoliberal turn" began as a reaction against the welfare state as it expanded during the New Deal and post-World War II period. What began as a movement associated with philosophers like Friedrich Hayek ultimately had a powerful impact via the attraction of powerful corporate sponsors and political supporters, and it was to historically transform American health care thought and organization. In health policy circles, for example, it can be seen in a rising emphasis on "moral hazard," overuse, and cost sharing above a concern with universalism and equity. It was likewise manifested by the corporatization of the health maintenance organization and the rise of the "consumer-driven" health care movement. By the time of the health care reform debate, the influence of corporate "stakeholders" was to prove predominant. These developments, however, must be construed as connected parts of a much larger political transformation, reflected in rising inequality and privatization, occurring both domestically and internationally.

  12. Cosmopolitan Pluralism: Beyond the Cultural Turn

    Directory of Open Access Journals (Sweden)

    Stephanie Lawson

    2011-11-01

    Full Text Available The ‘cultural turn’ has had a profound influence across the humanities and social sciences in the last few decades. In calling into question the universalist basis on which conventional methodological and normative assumptions have been based, the cultural turn has focused on the extent to which specificity and particularity underpin what we can know, how we can know it, and how this affects our being-in-the world. This has opened the way to a range of insights, from issues of pluralism and difference, both within political communities and between them, to the instability if not impossibility of foundations for knowledge. Too few studies embracing this ‘cultural turn’, however, pay more than cursory attention to the culture concept itself. This article suggests that conceptions of culture derived mainly from the discipline of anthropology dominate in political studies, including international relations, while humanist conceptions have been largely ignored or rejected. It argues further that we would do well to reconsider what humanist ideas can contribute to how ‘culture’ is both conceptualized and deployed in political thought and action, especially in countering the overparticularization of social and political phenomena that marks contemporary culturalist approaches.

  13. Now, It's Your Turn: How You Can Take Medicine Safely

    Science.gov (United States)

    ... please turn Javascript on. Feature: Taking Medicines Safely Now, It's Your Turn: How You Can Take Medicine ... a medicine. The pharmacist has filled the prescription. Now it's up to you to take the medicine ...

  14. Conversion of Human Steroid 5[beta]-Reductase (AKR1D1) into 3[beta]-Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: Example of Perfect Enzyme Engineering

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Mo; Drury, Jason E.; Christianson, David W.; Penning, Trevor M. (UPENN)

    2012-10-10

    Human aldo-keto reductase 1D1 (AKR1D1) and AKR1C enzymes are essential for bile acid biosynthesis and steroid hormone metabolism. AKR1D1 catalyzes the 5{beta}-reduction of {Delta}{sup 4}-3-ketosteroids, whereas AKR1C enzymes are hydroxysteroid dehydrogenases (HSDs). These enzymes share high sequence identity and catalyze 4-pro-(R)-hydride transfer from NADPH to an electrophilic carbon but differ in that one residue in the conserved AKR catalytic tetrad, His120 (AKR1D1 numbering), is substituted by a glutamate in AKR1D1. We find that the AKR1D1 E120H mutant abolishes 5{beta}-reductase activity and introduces HSD activity. However, the E120H mutant unexpectedly favors dihydrosteroids with the 5{alpha}-configuration and, unlike most of the AKR1C enzymes, shows a dominant stereochemical preference to act as a 3{beta}-HSD as opposed to a 3{alpha}-HSD. The catalytic efficiency achieved for 3{beta}-HSD activity is higher than that observed for any AKR to date. High resolution crystal structures of the E120H mutant in complex with epiandrosterone, 5{beta}-dihydrotestosterone, and {Delta}{sup 4}-androstene-3,17-dione elucidated the structural basis for this functional change. The glutamate-histidine substitution prevents a 3-ketosteroid from penetrating the active site so that hydride transfer is directed toward the C3 carbonyl group rather than the {Delta}{sup 4}-double bond and confers 3{beta}-HSD activity on the 5{beta}-reductase. Structures indicate that stereospecificity of HSD activity is achieved because the steroid flips over to present its {alpha}-face to the A-face of NADPH. This is in contrast to the AKR1C enzymes, which can invert stereochemistry when the steroid swings across the binding pocket. These studies show how a single point mutation in AKR1D1 can introduce HSD activity with unexpected configurational and stereochemical preference.

  15. 14 CFR 417.209 - Malfunction turn analysis.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Malfunction turn analysis. 417.209 Section...'s turning capability using a set of turn curves. The analysis must account for: (1) All trajectory... the thrusting phases of flight. The analysis must account for trajectory time intervals between...

  16. History of Education in Canada: Historiographic "Turns" and Widening Horizons

    Science.gov (United States)

    Bruno-Jofré, Rosa

    2014-01-01

    This paper explores major historiographic "turns" in history of education with a focus, although not exclusively, on English-speaking Canada. It addresses the transformative intellectual impact of the turn toward social history on the history of education, the impact of cultural history and the linguistic turn, the reception of Michel…

  17. First turn simulations in the cooler synchrotron COSY

    International Nuclear Information System (INIS)

    Dinev, D.

    1991-07-01

    This paper is devoted to the first turn correction and related problems in particle accelerators of synchrotron type. The paper consists of two parts. The first part is a survey of the existing methods for first turn steering. The second part is entirely devoted to the first turn in the cooler synchrotron COSY which is under assembling in KFA-Julich, Germany. (orig.)

  18. Turn-Based War Chess Model and Its Search Algorithm per Turn

    Directory of Open Access Journals (Sweden)

    Hai Nan

    2016-01-01

    Full Text Available War chess gaming has so far received insufficient attention but is a significant component of turn-based strategy games (TBS and is studied in this paper. First, a common game model is proposed through various existing war chess types. Based on the model, we propose a theory frame involving combinational optimization on the one hand and game tree search on the other hand. We also discuss a key problem, namely, that the number of the branching factors of each turn in the game tree is huge. Then, we propose two algorithms for searching in one turn to solve the problem: (1 enumeration by order; (2 enumeration by recursion. The main difference between these two is the permutation method used: the former uses the dictionary sequence method, while the latter uses the recursive permutation method. Finally, we prove that both of these algorithms are optimal, and we analyze the difference between their efficiencies. An important factor is the total time taken for the unit to expand until it achieves its reachable position. The factor, which is the total number of expansions that each unit makes in its reachable position, is set. The conclusion proposed is in terms of this factor: Enumeration by recursion is better than enumeration by order in all situations.

  19. A highly efficient type I β-turn mimetic simulating an Asx-Pro-turn-like structure.

    Science.gov (United States)

    Pinsker, Andrea; Einsiedel, Jürgen; Härterich, Steffen; Waibel, Reiner; Gmeiner, Peter

    2011-07-01

    Asx-Pro-turns have been identified with high frequency in protein structures nucleating type I β-turns. By bridging the amino acid side chain in position i with a nitrogen substituent in position i+2 by ring-closing olefin metathesis (RCM), peptide mimetics of type 1 could be developed. NMR based conformational investigations indicated a stable intramolecular H-bond constraining a U-turn conformation that was predicted to simulate a type I β-turn.

  20. Some genus 3 curves with many points

    NARCIS (Netherlands)

    Auer, R; Top, J; Fieker, C; Kohel, DR

    2002-01-01

    We explain a naive approach towards the problem of finding genus 3 curves C over any given finite field F-q of odd characteristic, with a number of rational points close to the Hasse-Weil-Serre upper bound q+1+3[2rootq]. The method turns out to be successful at least in characteristic 3.

  1. Out-of-plane integration of a multimode optical fiber for single particle/cell detection at multiple points on a microfluidic device with applications to particle/cell counting, velocimetry, size discrimination and the analysis of single cell lysate injections.

    Science.gov (United States)

    Sadeghi, Jalal; Patabadige, Damith E W; Culbertson, Anne H; Latifi, Hamid; Culbertson, Christopher T

    2016-12-20

    In this paper a single particle/cell-tracking microfluidic device that integrates an out-of-plane multimode optical fiber (OP-MMF) is reported. This OP-MMF is used to generate three excitation light-lines and three detection spots using only one excitation source and one detector. It takes advantage of an optical tunneling mode to create two excitation lines in a microfluidic channel emanating from a single fiber end. This method was used to accurately count particles/cells and perform velocity measurements and size discrimination. The velocity and size distributions of 5, 7, and 10 μm fluorescently labeled polystyrene beads were determined using the OP-MMF. Additionally, this method was used to analyze cell lysates with the third excitation line in the separation channel. The OP-MMF setup accurately detected an intact cell twice ∼2 mm prior to lysis, determined its velocity, and detected the injected cell lysate 3 mm downstream of the injection point in the separation channel. Using this setup, the velocity of cells entering the lysis intersection and the absolute migration times of fluorescently labeled analytes injected into the separation channel were determined in an automated fashion. This method enabled us to determine a lysing/injection efficiency coefficient (K) using signals from the injected lysate signal and from the intact cell before lysing. K provided a reliable measurement of the amount of cell lysate that was injected into the separation channel. The approach reported here could be used in the future to track particles, cells or droplets in a variety of existing microfluidic devices without the need for multiplexed masks, layers, bulky optical elements or complex optical designs.

  2. Can helical spring dextrin be composed of higher eight glucose units per turn?

    Science.gov (United States)

    Xu, Jin; Zhao, Wenxiu; Ning, Yawei; Bashari, Mohanad; Jin, Zhengyu; Xu, Baocai; Zhang, Lixia; Duan, Xiang; Chen, Haiying; Wu, Fengfeng; Xu, Xueming

    2013-03-01

    In this study, spring dextrin (SD) has been noncovalently wrapped onto single-wall carbon nanotubes (SWNTs) to explain the number of glucose residues per turn larger than eight. Differential scanning calorimetry (DSC), FR-IR and Raman spectroscopy demonstrated that SD formed supramolecular complex with SWNTs. Furthermore, Atomic force microscope (AFM) micrograph indicated that SD wrap around SWNTs into helical superstructures. Finally, molecular dynamic simulation suggested that the space of helix cavity changed with different diameter of SWNTs, and SD wrapped around SWNTs (1 nm, 1.5 nm and 2 nm) were 11, 14 and 17 glucose units per turn, respectively.

  3. and γγ-turns in proteins revisited: A new set of amino acid turn-type de

    Indian Academy of Sciences (India)

    mine, valine, glutamic acid and alanine has decreased for β-turns. Certain new amino acid preferences were observed for both turn types and individual amino acids showed turn-type dependent positional preferences. The rationale for new amino acid preferences are discussed in the light of hydrogen bonds and other.

  4. and γγ-turns in proteins revisited: A new set of amino acid turn-type de

    Indian Academy of Sciences (India)

    cent Protein Data Bank has nearly doubled and the number of γ-turns in a representative set of 320 proteins has in- creased over seven times since the previous analysis. β-turns (7153) and γ-turns (911) extracted from these proteins were used to derive a revised set of type-dependent amino acid positional preferences and ...

  5. The spatiotemporal constraint on the swimmer’s decision-making of turning

    Directory of Open Access Journals (Sweden)

    Thiago A. Costa de Oliveira

    2014-09-01

    Full Text Available This study investigated the swimmer’s decision-making process for turning, based on spatiotemporal informational variables. The men and women 50-metre front crawl and backstroke events were selected and analyzed using TACTO software. Participants included 120 adults of both genders aged between 20 and 70 years. The distance to the pool wall at which the swimmers initiated the turn was analyzed with regards to velocity and variability of previous displacement. These factors were split into four groups adopting, quartiles as the cut-off points. Results showed that for all conditions, the swimmers who showed a higher velocity and a lower variability of displacement decided to initiate the turn at a greater distance to the pool wall. Furthermore, the greater distance seemed to be associated with a more successful performance. These results suggest that swimmers should be attuned to spatiotemporal and spatial information in order to maximize their performance.

  6. Experimental study of the diamond turning characteristics of tungsten carbide (Co 0.5%) when using a chamfered diamond bite

    Science.gov (United States)

    Kim, Min Jae; Lee, June Key; Hwang, Yeon; Cha, Du Hwan; Kim, Hye Jeong; Kim, Jeong Ho

    2012-11-01

    Tungsten carbide (WC) is a widely used as a mold material for fabrication of glass lens because of its superior properties. Due to its extremely high hardness (R c > 90), an abrasive machining process, although unproductive and expensive, is used to fabricate the mold. In this research, the authors investigated the machining possibility of tungsten carbide by single-point diamond turning (SPDT) for fabricating high-quality optical surfaces directly. A finite element analysis (FEA) was carried out in order to investigate the effects of the chamfered length on the cutting forces and the strain rate of single-crystal diamond tools. The obtained FEA results showed that a smaller chamfered length decreased the bite strain rate. The performance characteristics in terms of surface roughness (R a ) and tool wear (VB max ) of a conventional bite and a chamfered bite under same machining conditions were studied, the results were compared. Experimental results suggest that the chamfered bite wased a better performance than the conventional bite in terms of tool wear resistance. The WC surface machined by using the chamfered bite showed a 2.26 nm roughness (R a ), which is suitable for the fabrication of glass lenses.

  7. Mapping the Glocal Turn: Literature Streams, Scholarship Clusters and Debates

    Directory of Open Access Journals (Sweden)

    Victor Roudometof

    2015-12-01

    accidental that the glocal has been invoked in the context of discussions about the “participatory web” or “Web 2.0” (Boyd 2005. It is obviously impossible to address all the twists and turns within the multitude of fields that have employed the terms glocal and glocalization in the course of a single discussion. Inevitably, a full treatment is reserved for a lengthier and more in-depth discussion elsewhere (Roudometof Forthcoming. In the following, then, I restrict myself to an overview of the employment of the glocal. Although I briefly touch on the employment of glocalization in business, I nonetheless concentrate on the humanities and social sciences. The goal is to present an overview of the various bodies of literature, to identify and discuss clusters of scholarship where glocalization is among the important research foci and to offer a brief overview of emerging debates within this nascent field of study. As I have stated elsewhere (Roudometof 2015 the glocal is a new word whose origins most likely lie somewhere in the early 1990s. It stands in sharp contrast to the global, the appearance of which dates back to the late 19th or early 20th centuries. The emergence of the glocal in scholarly discourse is a feature of the post-1989 era, and its rise has been ubiquitous after the turn of the millennium.

  8. Turn me on! Using the “Internet of Things” to turn things on and off

    CSIR Research Space (South Africa)

    Butgereit, L

    2011-10-01

    Full Text Available -directional. The thing in question is automatically posting data to a location on the Internet for people to read. Bi-directional communication between people and things via the Internet is less common. This paper describes a project TurnMeOn where people... traversed numerous times in this project leading to a final conclusion step. 4 General Architecture There are three major components of the platform: ThingMemory, Beachcomber, and UrbanControl. ThingMemory supplies the web interface and a...

  9. Equations for arithmetic pointed tori

    NARCIS (Netherlands)

    Sijsling, J.R.

    2010-01-01

    In 1983, Kisao Takeuchi enumerated all 71 arithmetic (1;e)-groups. This is a special set of discrete subgroups of SL(2,R) of finite covolume and signature (1;e). The corresponding quotients of the upper half plane (called (1;e)-curves) have genus equal to 1 and a single elliptic point of order e.

  10. Full-turn symplectic map from a generator in a Fourier-spline basis

    International Nuclear Information System (INIS)

    Berg, J.S.; Warnock, R.L.; Ruth, R.D.; Forest, E.

    1993-04-01

    Given an arbitrary symplectic tracking code, one can construct a full-turn symplectic map that approximates the result of the code to high accuracy. The map is defined implicitly by a mixed-variable generating function. The implicit definition is no great drawback in practice, thanks to an efficient use of Newton's method to solve for the explicit map at each iteration. The generator is represented by a Fourier series in angle variables, with coefficients given as B-spline functions of action variables. It is constructed by using results of single-turn tracking from many initial conditions. The method has been appliedto a realistic model of the SSC in three degrees of freedom. Orbits can be mapped symplectically for 10 7 turns on an IBM RS6000 model 320 workstation, in a run of about one day

  11. Diamond-turning HP-21 beryllium to achieve an optical surface

    International Nuclear Information System (INIS)

    Allen, D.K.; Hauschildt, H.W.; Bryan, J.B.

    1975-01-01

    Investigation of diamond turning on beryllium was made in anticipation of obtaining an optical finish. Although results of past experiences were poor, it was decided to continue diamond turning on beryllium beyond initial failures. By changing speed and using coolant, partial success was achieved. Tool wear was the major problem. Tests were made to establish and plot wear as a function of cutting speed and time. Slower speeds did cause lower wear rates, but at no time did wear reach an acceptable level. The machine, tools, and procedure used were chosen based on the results of preliminary attempts and on previous experience. It was unnecessary to use an air-bearing spindle because tool failure governed the best finish that could be expected. All tools of diamond composition, whether single crystal or polycrystalline, wore at unacceptable rates. Based on present technology, it must be concluded that beryllium cannot be feasibly diamond turned to achieve an optical finish. (22 fig.)

  12. Address Points - Allegheny County Address Points 201601

    Data.gov (United States)

    NSGIC Education | GIS Inventory — This dataset contains Address Points in Allegheny County. The Address Points were created by GDR for the Allegheny County CAD project, October 2008. Data is updated...

  13. Characterization of beta-turn and Asx-turns mimicry in a model peptide: stabilization via C--H . . . O interaction.

    Science.gov (United States)

    Thakur, A K; Kishore, R

    2006-04-15

    The chemical synthesis and single-crystal X-ray diffraction analysis of a model peptide, Boc-Thr-Thr-NH2 (1) comprised of proteinogenic residues bearing an amphiphilic Cbeta -stereogenic center, has been described. Interestingly, the analysis of its molecular structure revealed the existence of a distinct conformation that mimics a typical beta-turn and Asx-turns, i.e., the two Thr residues occupy the left- and right-corner positions. The main-chain torsion angles of the N- and C-terminal residues i.e., semiextended: phi = -68.9 degrees , psi = 128.6 degrees ; semifolded: phi = -138.1 degrees , psi = 2.5 degrees conformations, respectively, in conjunction with a gauche- disposition of the obligatory C-terminus Thr CgammaH3 group, characterize the occurrence of the newly described beta-turn- and Asx-turns-like topology. The preferred molecular structure is suggested to be stabilized by an effective nonconventional main-chain to side-chain Ci=O . . . H--Cgamma(i+2)-type intraturn hydrogen bond. Noteworthy, the observed topology of the resulting 10-membered hydrogen-bonded ring is essentially similar to the one perceived for a classical beta-turn and the Asx-turns, stabilized by a conventional intraturn hydrogen bond. Considering the signs as well as magnitudes of the backbone torsion angles and the orientation of the central peptide bond, the overall mimicked topology resembles the type II beta-turn or type II Asx-turns. An analysis of Xaa-Thr sequences in high-resolution X-ray elucidated protein structures revealed the novel topology prevalence in functional proteins (unpublished). In view of indubitable structural as well as functional importance of nonconventional interactions in bioorganic and biomacromolecules, we intend to highlight the participation of Thr CgammaH in the creation of a short-range C=O . . . H--Cgamma -type interaction in peptides and proteins. Copyright 2006 Wiley Periodicals, Inc.

  14. Swine manure composting by means of experimental turning equipment.

    Science.gov (United States)

    Chiumenti, A; Da Borso, F; Rodar, T; Chiumenti, R

    2007-01-01

    The purpose of research was to test the effectiveness of a prototype of a turning machine and to evaluate the feasability of a farm-scale composting process of the solid fraction of swine manure. A qualitative evaluation of the process and final product was made by monitoring the following parameters: process temperature, oxygen concentration inside the biomass, gaseous emissions (CH4, CO2, NH3, N2O), respiration index, humification index, total and volatile solids, carbon and nitrogen, pH and microbial load. The prototype proved to be very effective from a technical-operational point of view. The composting process exhibited a typical time-history, characterised by a thermophilic phase followed by a curing phase [Chiumenti, A., Chiumenti, R., Diaz, L.F., Savage, G.M., Eggerth, L.L., Goldstein, N., 2005. Modern Composting Technologies. BioCycle-JG Press, Emmaus, PA, USA]. Gas emissions from compost the windrow were more intense during the active phase of the process and showed a decreasing trend from the thermophilic to the curing phase. The final compost was characterized by good qualitative characteristics, a significant level of humification [Rossi, L., Piccinini, S., 1999. La qualità agronomica dei compost derivanti da liquami suinicoli. (Agronomic quality of swine manure compost). L'informatore Agrario 38, 29-31] and no odor emissions. This method of managing manure represents an effective, low cost approach that could be an interesting opportunity for swine farms.

  15. Software engineering turning theory into practice

    CERN Document Server

    Jones, Robert

    1996-01-01

    The term 'Software Engineering' was coined in the mid 1960s, it is said, as a challenge to the software community to start rationalising the software production process. Software engineering is a very young discipline and this challenge still eludes LHC demands software production on a scale far beyond that previously addressed in HEP and we are relying on software engineering to allow a significant number of people address this problem collectively. This series of lectures presents the basics of software engineering from the developer's point of view. The aim is to show how individual developers can improve the quality of the software they produce while avoiding the conflict between the creative process of designing software and the organisational needs of large projects.The Laser Interferometer Gravitanional Wave Observatory (LIGO) is being constructed with a goal to detect these waves and then to use them as a new tool to explore and study The sources of gravitanional waves and techniques for detection wil...

  16. Spatiotemporal and Kinematic Parameters Relating to Oriented Gait and Turn Performance in Patients with Chronic Stroke.

    Directory of Open Access Journals (Sweden)

    Céline Bonnyaud

    Full Text Available The timed up and go test (TUG is a functional test which is increasingly used to evaluate patients with stroke. The outcome measured is usually global TUG performance-time. Assessment of spatiotemporal and kinematic parameters during the Oriented gait and Turn sub-tasks of the TUG would provide a better understanding of the mechanisms underlying patients' performance and therefore may help to guide rehabilitation. The aim of this study was thus to determine the spatiotemporal and kinematic parameters which were most related to the walking and turning sub-tasks of TUG performance in stroke patients.29 stroke patients carried out the TUG test which was recorded using an optoelectronic system in two conditions: spontaneous and standardized condition (standardized foot position and instructed to turn towards the paretic side. They also underwent a clinical assessment. Stepwise regression was used to determine the parameters most related to Oriented gait and Turn sub-tasks. Relationships between explanatory parameters of Oriented gait and Turn performance and clinical scales were evaluated using Spearman correlations.Step length and cadence explained 82% to 95% of the variance for the walking sub-tasks in both conditions. Percentage single support phase and contralateral swing phase (depending on the condition respectively explained 27% and 56% of the variance during the turning sub-task in the spontaneous and standardized conditions.Step length, cadence, percentage of paretic single support phase and non-paretic swing phase, as well as dynamic stability were the main parameters related to TUG performance and they should be targeted in rehabilitation.

  17. CERN's Community "Log Book" turns 50

    CERN Document Server

    Katarina Anthony

    2015-01-01

    For five decades, the CERN Bulletin has been a staple of the Organization. As CERN has grown as a laboratory and a community, the Bulletin has been there to cover each development as it happens. In honour of the publication's 50th anniversary, we're taking a trip through CERN’s history via the headings and hidden corners of its internal newsletter.     It's 1965 and CERN - now 11 years old - has matured from a simple lab to a fledgling community. While news could once spread in a single afternoon, CERN's growth necessitated a new approach to the sharing of internal information. Meanwhile, the CERN Courier - the only publication in town - was approaching a more global physics audience – an audience for whom CERN road closures were not breaking news. And so, in March 1965, the Weekly Bulletin was born. What was meant as a simple newsletter of events and internal announcements quickly developed into a wider source of news about CERN....

  18. The turn team: a novel strategy for reducing pressure ulcers in the surgical intensive care unit.

    Science.gov (United States)

    Still, Mary D; Cross, Linda C; Dunlap, Martha; Rencher, Rugenia; Larkins, Elizabeth R; Carpenter, David L; Buchman, Timothy G; Coopersmith, Craig M

    2013-03-01

    Pressure ulcers cause significant morbidity and mortality in the surgical intensive care unit (SICU). The purpose of this study was to determine if a dedicated team tasked with turning and repositioning all hemodynamically stable SICU patients could decrease the formation of pressure ulcers. A total of 507 patients in a 20-bed SICU in a university hospital were assessed for pressure ulcers using a point prevalence strategy, between December 2008 and September 2010, before and after implementation of a team tasked with turning and repositioning all hemodynamically stable patients every 2 hours around the clock. At baseline, when frequent turning was encouraged but not required, a total of 42 pressure ulcers were identified in 278 patients. After implementation of the turn team, a total of 12 pressure ulcers were identified in 229 patients (p < 0.0001). The preintervention group included 34 stage I and II ulcers and 8 higher stage ulcers. After implementation of the turn team, there were 7 stage I and II ulcers and 5 higher stage ulcers. The average Braden score was 16.5 in the preintervention group and 13.4 in the postintervention group (p = 0.04), suggesting that pressure ulcers were occurring in higher risk patients after implementation of the turn team. A team dedicated to turning SICU patients every 2 hours dramatically decreased the incidence of pressure ulcers. The majority of stage I and stage II ulcers appear to be preventable with an aggressive intervention aimed at pressure ulcer prevention. Copyright © 2013 American College of Surgeons. Published by Elsevier Inc. All rights reserved.

  19. Access to Liver Transplantation in Different ABO-Blood Groups and "Exceptions Points" in a Model for End-Stage Liver Disease Allocation System: A Brazilian Single-Center Study.

    Science.gov (United States)

    Martino, R B; Waisberg, D R; Dias, A P M; Inoue, V B S; Arantes, R M; Haddad, L B P; Rocha-Santos, V; Pinheiro, R S N; Nacif, L S; D'Albuquerque, L A C

    2018-04-01

    In the Model for End-Stage Liver Disease (MELD) system, patients with "MELD exceptions" points may have unfair privilege in the competition for liver grafts. Furthermore, organ distribution following identical ABO blood types may also result in unjust organ allocation. The aim of this study was to investigate access to liver transplantation in a tertiary Brazilian center, regarding "MELD exceptions" situations and among ABO-blood groups. A total of 465 adult patients on the liver waitlist from August 2015 to August 2016 were followed up until August 2017. Patients were divided into groups according to ABO-blood type and presence of "exceptions points." No differences in outcomes were observed among ABO-blood groups. However, patients from B and AB blood types spent less time on the list than patients from A and O groups (median, 46, 176, 415, and 401 days, respectively; P = .03). "Exceptions points" were granted for 141 patients (30.1%), hepatocellular carcinoma being the most common reason (52.4%). Patients with "exceptions points" showed higher transplantation rate, lower mortality on the list, and lower delta-MELD than non-exceptions patients (56.7% vs 19.1% [P blood types, despite shorter time on the waitlist for AB and B groups. The current MELD exception system provides advantages for candidates with "exception points," resulting in superior outcomes compared with those without exceptions. Copyright © 2018 Elsevier Inc. All rights reserved.

  20. Mechanisms for turn alternation in four invertebrate species.

    Science.gov (United States)

    Hughes, R N

    1987-02-01

    Free-choice behavior following one or more forced turns was observed in representatives of four invertebrate classes (earthworms, woodlice, millipedes, earwigs). While all animals alternated, species differences occurred in free turn angle and the effects of varied angle and number of forced turns. Overall, woodlice and millipedes turned at sharper angles and responded more to the forced turn conditions than earthworms and earwigs. From behavior observed following three forced turns in one direction and then one in the opposite, it was concluded that, in earlier experiments, earthworms alternated via tactile cues, woodlice mainly used kinesthetic but could also use tactile cues, millipedes mainly used tactile but could also use kinesthetic cues and earwigs may have relied on kinesthetic cues alone. Since phyletic differences did not seem appropriate, the results were discussed in terms of other characteristics such as body shape and life style. Copyright © 1987. Published by Elsevier B.V.