Sample records for single orbital cycle

  1. Single particle closed orbits in Yukawa potential (United States)

    Mukherjee, R.; Sounda, S.


    Orbit of a single particle moving under the Yukawa potential is studied and there exists precessing ellipse type orbits. The amount of precession can be tuned through the coupling parameter α. With a suitable choice of the coupling parameter; we get a closed bound orbit. In some cases few petals are observed which is possessed of a closed bound nature for suitably chosen coupling parameter. Threshold energy has also been calculated for bound orbits.

  2. Tropical sea surface temperatures and the earth's orbital eccentricity cycles

    Digital Repository Service at National Institute of Oceanography (India)

    Gupta, S.M.; Fernandes, A.A.; Mohan, R.

    cyclicities at ~100- and ~400-ka corresponding to the Earth's orbital eccentricity cycles. Results, therefore imply that the tropical Indian Ocean warm pool persisted during the Quaternary and the paleo-SSTs fluctuating at the orbital eccentricity frequencies...

  3. Continuation of connecting orbits in 3d-ODEs. (ii) cycle-to-cycle connections.

    NARCIS (Netherlands)

    Doedel, E.J.; Kooi, B.W.; van Voorn, G.A.K.; Kuznetzov, Y.A.


    In Part I of this paper we have discussed new methods for the numerical continuation of point-to-cycle connecting orbits in three-dimensional autonomous ODE's using projection boundary conditions. In this second part we extend the method to the numerical continuation of cycle-to-cycle connecting

  4. Orbital forcing of the Paleocene and Eocene carbon cycle (United States)

    Zeebe, Richard E.; Westerhold, Thomas; Littler, Kate; Zachos, James C.


    Multimillion-year proxy records across the Paleocene and Eocene show prominent variations on orbital time scales. The cycles, which have been identified at various sites across the globe, preferentially concentrate spectral power at eccentricity and precessional frequencies. It is evident that these cycles are an expression of changes in global climate and carbon cycling paced by astronomical forcing. However, little is currently known about the link between orbital forcing and the carbon cycle-climate system and the amplitude of associated atmospheric CO2 variations. Here we use simple and complex carbon cycle models to explore the basic effect of different orbital forcing schemes and noise on the carbon cycle. Our primary modeling target is the high-resolution, ˜7.7 Myr long, benthic isotope record at Ocean Drilling Program Site 1262 in the South Atlantic. For direct insolation forcing (as opposed to artificial eccentricity-tilt-precession), one major challenge is understanding how the system transfers spectral power from high to low frequencies. We discuss feasible solutions, including insolation transformations analogous to electronic AC-DC conversion (DC'ing). Regarding mechanisms, we focus on tropical insolation and a long-term carbon imbalance in terrestrial organic burial/oxidation but do not rule out other scenarios. Our analysis shows that high-latitude mechanisms are unlikely drivers of orbitally paced changes in the late Paleocene-early Eocene (LPEE) Earth system. Furthermore, we provide constraints on the origin and isotopic composition of a possible LPEE cyclic carbon imbalance/source responding to astronomical forcing. Our simulations also reveal a mechanism for the large δ13C-eccentricity lag at the 400 kyr period observed in Paleocene, Oligocene, and Miocene sections. We present the first estimates of orbital-scale variations in atmospheric CO2 during the late Paleocene and early Eocene.

  5. Thermo-optical "canard orbits" and excitable limit cycles. (United States)

    Marino, Francesco; Catalán, Gustau; Sánchez, Pedro; Balle, Salvador; Piro, Oreste


    We demonstrate experimentally and theoretically the existence of canard orbits and excitable quasiharmonic limit cycles in the thermo-optical dynamics of semiconductor optical amplifiers. We also observe the phase locking of the noise-induced spikes to the small-amplitude Hopf quasiharmonic oscillations, recently predicted by Makarov, Nekorkin, and Velarde [Phys. Rev. Lett. 86, 3431 (2001)

  6. Intrinsic chirp of single-cycle pulses

    International Nuclear Information System (INIS)

    Lin Qiang; Zheng Jian; Dai Jianming; Ho, I-Chen; Zhang, X.-C.


    The Fourier transform-limited electromagnetic pulse has been regarded to be free of chirps for a long time. This is no longer true if the pulse duration goes down to or less than one optical cycle. We report the experimental observation of intrinsic chirps in such pulses with the sub-single-cycle terahertz (THz) waveforms obtained with a standard THz time-domain spectroscopy system. The results confirm the break down of the carrier-envelope (CE) expression for single-cycle optical pulses, and may influence the experimental measurements and theoretical modeling with single-cycle pulses.

  7. Thermo-Optical ``Canard Orbits'' and Excitable Limit Cycles (United States)

    Marino, Francesco; Catalán, Gustau; Sánchez, Pedro; Balle, Salvador; Piro, Oreste


    We demonstrate experimentally and theoretically the existence of canard orbits and excitable quasiharmonic limit cycles in the thermo-optical dynamics of semiconductor optical amplifiers. We also observe the phase locking of the noise-induced spikes to the small-amplitude Hopf quasiharmonic oscillations, recently predicted by Makarov, Nekorkin, and Velarde [Phys. Rev. Lett.PRLTAO0031-9007 86, 3431 (2001)10.1103/PhysRevLett.86.3431].

  8. Spectrum of 100-kyr glacial cycle: orbital inclination, not eccentricity. (United States)

    Muller, R A; MacDonald, G J


    Spectral analysis of climate data shows a strong narrow peak with period approximately 100 kyr, attributed by the Milankovitch theory to changes in the eccentricity of the earth's orbit. The narrowness of the peak does suggest an astronomical origin; however the shape of the peak is incompatible with both linear and nonlinear models that attribute the cycle to eccentricity or (equivalently) to the envelope of the precession. In contrast, the orbital inclination parameter gives a good match to both the spectrum and bispectrum of the climate data. Extraterrestrial accretion from meteoroids or interplanetary dust is proposed as a mechanism that could link inclination to climate, and experimental tests are described that could prove or disprove this hypothesis.

  9. Manipulating localized molecular orbitals by single-atom contacts. (United States)

    Wang, Weihua; Shi, Xingqiang; Lin, Chensheng; Zhang, Rui Qin; Minot, Christian; Van Hove, Michel A; Hong, Yuning; Tang, Ben Zhong; Lin, Nian


    We have fabricated atom-molecule contacts by attachment of single Cu atoms to terpyridine side groups of bis-terpyridine tetra-phenyl ethylene molecules on a Cu(111) surface. By means of scanning tunneling microscopy, spectroscopy, and density functional calculations, we have found that, due to the localization characteristics of molecular orbitals, the Cu-atom contact modifies the state localized at the terpyridine side group which is in contact with the Cu atom but does not affect the states localized at other parts of the molecule. These results illustrate the contact effects at individual orbitals and offer possibilities to manipulate orbital alignments within molecules.

  10. Single particle orbitals of the heaviest known actinide nuclei

    International Nuclear Information System (INIS)

    Ahmad, I.


    Single particle states in the actinide nuclei have been well characterized by decay scheme, (n, γ) and one nucleon transfer reaction studies. The energies of the single particle states are used to calculate the shell corrections which may give rise to stable superheavy elements. Large shell corrections for the superheavy elements arise from the gaps in the proton single-particle spectrum at Z = 114 and in the neutron single-particle spectrum at N = 184. The gap at Z = 114 is determined by the splitting of the f 7/2 and f 5/2 orbitals and the gap at N = 184 is determined by the locations of the h 11/2 , k 17/2 and j 13/2 spherical orbitals. Many of these states have been identified in very heavy actinide nuclei. Experiments identifying these states and the relation of the observed energies to the stability of superheavy elements are discussed

  11. Effective operators in a single-j orbital (United States)

    Derbali, E.; Van Isacker, P.; Tellili, B.; Souga, C.


    We present an analysis of effective operators in the shell model with up to three-body interactions in the Hamiltonian and two-body terms in electromagnetic transition operators when the nucleons are either neutrons or protons occupying a single-j orbital. We first show that evidence for an effective three-body interaction exists in the N = 50 isotones and in the lead isotopes but that the separate components of such interaction are difficult to obtain empirically. We then determine higher-order terms on more microscopic grounds. The starting point is a realistic two-body interaction in a large shell-model space together with a standard one-body transition operator, which, after restriction to the dominant orbital and with use of stationary perturbation theory, are transformed into effective versions with higher-order terms. An application is presented for the lead isotopes with neutrons in the 1{g}9/2 orbital.

  12. Shuttle orbit IMU alignment. Single-precision computation error (United States)

    Mcclain, C. R.


    The source of computational error in the inertial measurement unit (IMU) onorbit alignment software was investigated. Simulation runs were made on the IBM 360/70 computer with the IMU orbit alignment software coded in hal/s. The results indicate that for small IMU misalignment angles (less than 600 arc seconds), single precision computations in combination with the arc cosine method of eigen rotation angle extraction introduces an additional misalignment error of up to 230 arc seconds per axis. Use of the arc sine method, however, produced negligible misalignment error. As a result of this study, the arc sine method was recommended for use in the IMU onorbit alignment software.

  13. Exo-Milankovitch Cycles. I. Orbits and Rotation States (United States)

    Deitrick, Russell; Barnes, Rory; Quinn, Thomas R.; Armstrong, John; Charnay, Benjamin; Wilhelm, Caitlyn


    The obliquity of the Earth, which controls our seasons, varies by only ∼2.°5 over ∼40,000 years, and its eccentricity varies by only ∼0.05 over 100,000 years. Nonetheless, these small variations influence Earth’s ice ages. For exoplanets, however, variations can be significantly larger. Previous studies of the habitability of moonless Earth-like exoplanets have found that high obliquities, high eccentricities, and dynamical variations can extend the outer edge of the habitable zone by preventing runaway glaciation (snowball states). We expand upon these studies by exploring the orbital dynamics with a semianalytic model that allows us to map broad regions of parameter space. We find that, in general, the largest drivers of obliquity variations are secular spin–orbit resonances. We show how the obliquity varies in several test cases, including Kepler-62 f, across a wide range of orbital and spin parameters. These obliquity variations, alongside orbital variations, will have a dramatic impact on the climates of such planets.

  14. Prediction of orbit decay through next solar cycle solar mesosphere explorer (United States)

    Tobiska, K.; Culp, R. D.; Barth, C. A.


    This study develops an empirical model of the thermospheric densities through the next solar cycle as it relates to the problem of low-earth orbit satellite drag and orbit decay. A comparison is done between the predicted orbit decay using the model and the first 37 months of actual altitude decay of the Solar Mesosphere Explorer (SME) satellite. Predictions of less than a year have led to less than 1 km difference between actual and modeled altitudes. Medium term predictions (5 years) indicate a 5 km range of uncertainty, while the long term prediction points to under a year probable reentry interval during the mid-1990s. Numerical results are given for the model and are compared to the definitive ephemeris data. The simplified semianalytic method of orbit determination with drag perturbation used here is valid only for near circular orbit satellites.

  15. Towards the integration of orbital space use in Life Cycle Impact Assessment. (United States)

    Maury, Thibaut; Loubet, Philippe; Ouziel, Jonathan; Saint-Amand, Maud; Dariol, Ludovic; Sonnemann, Guido


    A rising sustainability concern is occurring in the space sector: 29,000 human-made objects, larger than 10cm are orbiting the Earth but only 6% are operational spacecrafts. Today, space debris is today a significant and constant danger to all space missions. Consequently, it becomes compelled to design new space missions considering End-of-Life requirements in order to ensure the sustainable use of space orbits. Furthermore, Life Cycle Assessment (LCA) has been identified by the European Space Agency as an adequate tool to measure the environmental impact of spacecraft missions. Hence, our challenge is to integrate orbital space use into Life Cycle Impact Assessment (LCIA) to broaden the scope of LCA for space systems. The generation of debris in the near-Earth's orbital regions leads to a decrease in volume availability. The Area-of-Protection (AoP) 'resources' seems to be the most relevant reflection of this depletion. To address orbital space use in a comprehensive way, we propose a first attempt at establishing an impact pathway linking outer space use to resources. This framework will be the basis for defining new indicator(s) related to orbital space use. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Next generation GNSS single receiver cycle slip reliability

    NARCIS (Netherlands)

    Teunissen, P.J.G.; De Bakker, P.F.


    In this contribution we study the multi-frequency, carrier-phase slip detection capabilities of a single receiver. Our analysis is based on an analytical expression that we present for themulti-frequencyminimal detectable carrier phase cycle slip.

  17. Orbits

    CERN Document Server

    Xu, Guochang


    This is the first book of the satellite era which describes orbit theory with analytical solutions of the second order with respect to all possible disturbances. Based on such theory, the algorithms of orbits determination are completely revolutionized.

  18. Circular revisit orbits design for responsive mission over a single target (United States)

    Li, Taibo; Xiang, Junhua; Wang, Zhaokui; Zhang, Yulin


    The responsive orbits play a key role in addressing the mission of Operationally Responsive Space (ORS) because of their capabilities. These capabilities are usually focused on supporting specific targets as opposed to providing global coverage. One subtype of responsive orbits is repeat coverage orbit which is nearly circular in most remote sensing applications. This paper deals with a special kind of repeating ground track orbit, referred to as circular revisit orbit. Different from traditional repeat coverage orbits, a satellite on circular revisit orbit can visit a target site at both the ascending and descending stages in one revisit cycle. This typology of trajectory allows a halving of the traditional revisit time and does a favor to get useful information for responsive applications. However the previous reported numerical methods in some references often cost lots of computation or fail to obtain such orbits. To overcome this difficulty, an analytical method to determine the existence conditions of the solutions to revisit orbits is presented in this paper. To this end, the mathematical model of circular revisit orbit is established under the central gravity model and the J2 perturbation. A constraint function of the circular revisit orbit is introduced, and the monotonicity of that function has been studied. The existent conditions and the number of such orbits are naturally worked out. Taking the launch cost into consideration, optimal design model of circular revisit orbit is established to achieve a best orbit which visits a target twice a day in the morning and in the afternoon respectively for several days. The result shows that it is effective to apply circular revisit orbits in responsive application such as reconnoiter of natural disaster.

  19. Orbital control on carbon cycle and oceanography in the mid-Cretaceous greenhouse (United States)

    Giorgioni, Martino; Weissert, Helmut; Bernasconi, Stefano M.; Hochuli, Peter A.; Coccioni, Rodolfo; Keller, Christina E.


    We established a new high-resolution carbonate carbon isotope record of the Albian interval of the Marne a Fucoidi Formation (Central Apennines, Italy), which was deposited on the southern margin of the western Tethys Ocean. Bulk carbonate sampled with 10-15 cm spacing was used for the construction of a continuous carbon isotope curve through the Albian stage. Spectral analyses reveal prominent 400 kyr cyclicity in the δ13C curve, which correlates with Milankovitch long eccentricity changes. Cycles occurring in our record resemble those observed in several Cenozoic δ13C records, suggesting that a link between orbital forcing and carbon cycling existed also under mid-Cretaceous greenhouse conditions. Based on comparisons with Cenozoic eccentricity-carbon cycle links we hypothesize that 400 kyr cycles in the mid-Cretaceous were related to a fluctuating monsoonal regime, coupled with an unstable oceanic structure, which made the oceanic carbon reservoir sensitive to orbital variations. In the Tethys these oceanographic conditions lasted until the Late Albian, and then were replaced by a more stable circulation mode, less sensitive to orbital forcing.

  20. A long marine history of carbon cycle modulation by orbital-climatic changes. (United States)

    Herbert, T D


    Pacing of the marine carbon cycle by orbital forcing during the Pliocene and Pleistocene Ice Ages [past 2.5 million years (Myr)] is well known. As older deep-sea sediment records are being studied at greater temporal resolution, it is becoming clear that similar fluctuations in the marine carbon system have occurred throughout the late Mesozoic and Tertiary, despite the absence of large continental ice sheets over much of this time. Variations in both the organic and the calcium carbonate components of the marine carbon system seem to have varied cyclically in response to climate forcing, and carbon and carbonate time series appear to accurately characterize the frequency spectrum of ancient climatic change. For the past 35 Myr, much of the variance in carbonate content carries the "polar" signal of obliquity [41,000 years (41 kyr)] forcing. Over the past 125 Myr, there is evidence from marine sediments of the continued role of precessional (approximately 21 kyr) climatic cycles. Repeat patterns of sedimentation at about 100, 400, and 2,400 kyr, the modulation periods of precession, persistently enter into marine carbon cycle records as well. These patterns suggest a nonlinear response of climate and/or the sedimentation of organic carbon and carbonates to precessional orbital perturbations. Nonlinear responses of the carbon system may help to amplify relatively weak orbital insolation anomalies into more significant climatic perturbations through positive feedback effects. Nonlinearities in the carbon cycle may have transformed orbital-climatic cycles into long-wavelength features on time scales comparable to the residence times of carbon and nutrient elements in the ocean.

  1. Orbital


    Yourshaw, Matthew Stephen


    Orbital is a virtual reality gaming experience designed to explore the use of traditional narrative structure to enhance immersion in virtual reality. The story structure of Orbital was developed based on the developmental steps of 'The Hero's Journey,' a narrative pattern identified by Joseph Campbell. Using this standard narrative pattern, Orbital is capable of immersing the player quickly and completely for the entirety of play time. MFA

  2. NOFBX Single-Stage-to-Orbit Mars Ascent Vehicle Engine, Phase II (United States)

    National Aeronautics and Space Administration — We propose the continuation of our research and development of a Nitrous Oxide Fuel Blend (NOFBXTM) Single-Stage-to-Orbit (SSTO) monopropellant propulsion system for...

  3. Spectrum of 100-kyr glacial cycle: Orbital inclination, not eccentricity (United States)

    Muller, Richard A.; MacDonald, Gordon J.


    Spectral analysis of climate data shows a strong narrow peak with period ≈100 kyr, attributed by the Milankovitch theory to changes in the eccentricity of the earth’s orbit. The narrowness of the peak does suggest an astronomical origin; however the shape of the peak is incompatible with both linear and nonlinear models that attribute the cycle to eccentricity or (equivalently) to the envelope of the precession. In contrast, the orbital inclination parameter gives a good match to both the spectrum and bispectrum of the climate data. Extraterrestrial accretion from meteoroids or interplanetary dust is proposed as a mechanism that could link inclination to climate, and experimental tests are described that could prove or disprove this hypothesis. PMID:11607741

  4. Energetic and exergetic Improvement of geothermal single flash cycle

    Directory of Open Access Journals (Sweden)

    Navid Nazari


    Full Text Available This paper presents a detailed analysis of a new method for improving energetic and exergetic efficiencies of single flash cycle. The thermodynamic process of the new method consists of extracting a fraction of hot wellhead geothermal brine for the purpose of superheating saturated steam entering the turbine. Computer programming scripts were developed and optimized based on mathematical proposed models for the different components of the systems. The operating parameters such as separator temperature, geofluid wellhead enthalpy and geothermal source temperature are varied to investigate their effects on both net power output and turbine exhaust quality of the systems. Also, full exergy assessment was performed for the new design. The results of separator temperature optimization revealed that specific net power output of the new design can be boosted up to 8% and turbine exhaust quality can be diminished up to 50% as compared to common single flash cycle. In addition, for wells with higher discharge enthalpy, superheating process improve specific net power output even up to 10%. Finally, it was observed that the overall system exergy efficiency was approximately raised 3%. Article History: Received January 5th 2016; Received in revised form June 25th 2016; Accepted July 3rd 2016; Available online How to Cite This Article: Nazari, N. and Porkhial, S. (2016. Energetic and Exergetic Improvement of Geothermal Single Flash Cycle. Int. Journal of Renewable Energy Development, 5(2,129-138. 

  5. Achievable debris orbit prediction accuracy using laser ranging data from a single station (United States)

    Sang, Jizhang; Bennett, James C.


    Earlier studies have shown that an orbit prediction accuracy of 20 arc sec ground station pointing error for 1-2 day predictions was achievable for low Earth orbit (LEO) debris using two passes of debris laser ranging (DLR) data from a single station, separated by about 24 h. The accuracy was determined by comparing the predicted orbits with subsequent tracking data from the same station. This accuracy statement might be over-optimistic for other parts of orbit far away from the station. This paper presents the achievable orbit prediction accuracy using satellite laser ranging (SLR) data of Starlette and Larets under a similar data scenario as that of DLR. The SLR data is corrupted with random errors of 1 m standard deviation so that its accuracy is similar to that of DLR data. The accurate ILRS Consolidated Prediction Format orbits are used as reference to compute the orbit prediction errors. The study demonstrates that accuracy of 20 arc sec for 1-2 day predictions is achievable.

  6. Chaos and nonlinear dynamics of single-particle orbits in a magnetotaillike magnetic field (United States)

    Chen, J.; Palmadesso, P. J.


    The properties of charged-particle motion in Hamiltonian dynamics are studied in a magnetotaillike magnetic field configuration. It is shown by numerical integration of the equation of motion that the system is generally nonintegrable and that the particle motion can be classified into three distinct types of orbits: bounded integrable orbits, unbounded stochastic orbits, and unbounded transient orbits. It is also shown that different regions of the phase space exhibit qualitatively different responses to external influences. The concept of 'differential memory' in single-particle distributions is proposed. Physical implications for the dynamical properties of the magnetotail plasmas and the possible generation of non-Maxwellian features in the distribution functions are discussed.

  7. Rapid near-optimal trajectory generation and guidance law development for single-stage-to-orbit airbreathing vehicles (United States)

    Calise, A. J.; Flandro, G. A.; Corban, J. E.


    General problems associated with on-board trajectory optimization, propulsion system cycle selection, and with the synthesis of guidance laws were addressed for an ascent to low-earth-orbit of an air-breathing single-stage-to-orbit vehicle. The NASA Generic Hypersonic Aerodynamic Model Example and the Langley Accelerator aerodynamic sets were acquired and implemented. Work related to the development of purely analytic aerodynamic models was also performed at a low level. A generic model of a multi-mode propulsion system was developed that includes turbojet, ramjet, scramjet, and rocket engine cycles. Provisions were made in the dynamic model for a component of thrust normal to the flight path. Computational results, which characterize the nonlinear sensitivity of scramjet performance to changes in vehicle angle of attack, were obtained and incorporated into the engine model. Additional trajectory constraints were introduced: maximum dynamic pressure; maximum aerodynamic heating rate per unit area; angle of attack and lift limits; and limits on acceleration both along and normal to the flight path. The remainder of the effort focused on required modifications to a previously derived algorithm when the model complexity cited above was added. In particular, analytic switching conditions were derived which, under appropriate assumptions, govern optimal transition from one propulsion mode to another for two cases: the case in which engine cycle operations can overlap, and the case in which engine cycle operations are mutually exclusive. The resulting guidance algorithm was implemented in software and exercised extensively. It was found that the approximations associated with the assumed time scale separation employed in this work are reasonable except over the Mach range from roughly 5 to 8. This phenomenon is due to the very large thrust capability of scramjets in this Mach regime when sized to meet the requirement for ascent to orbit. By accounting for flight path

  8. What is the Time Scale for Orbital Forcing of the Martian Water Cycle? (United States)

    Hecht, M. H.


    Calculation of the periodic variations in the martian orbital parameters by Ward and subsequent refinements to the theory have inspired numerous models of variation of the martian water cycle. Most of these models have focused on variations in planetary obliquity on a both a short-term (110 kyr) time scale as well as larger oscillations occuring over millions of years. To a lesser extent, variations in planetary eccentricity have also been considered. The third and fastest mode of variation, the precession of the longitude of perihelion, has generally been deemphasized because, among the three parameters, it is the only one that does not change the integrated annual insolation. But as a result of this precession, the asymmetry in peak summer insolation between the poles exceeds 50%, with the maximum cycling between poles every 25.5 kyrs. The relative contribution of these different elements to orbital forcing of climate takes on particular importance in the context of apparently recent waterrelated features such as gullies or polar layered deposits (PLD). Christensen, for example, recently indentified mantling of heavily gullied crater walls as residual dust-covered snow deposits that were responsible for the formation of the gullies in a previous epoch. Christensen assumed that the snow was originally deposited at a period of high obliquity which was stabilized against sublimation by a lag deposit of dust. It is suggested here that not obliquity, but the shortterm oscillations associated with precession of the perihelion may play the dominant role in the formation of gullies, major strata in the polar layered deposits (PLD), and other water-related features.

  9. Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme.

    Directory of Open Access Journals (Sweden)

    Ping Zhang


    Full Text Available To provide tight spatiotemporal signaling control, the cyclic adenosine monophosphate (cAMP-dependent protein kinase (PKA holoenzyme typically nucleates a macromolecular complex or a "PKA signalosome." Using the RIIβ holoenzyme as a prototype, we show how autophosphorylation/dephosphorylation of the RIIβ subunit, as well as cAMP and metal ions, contribute to the dynamics of PKA signaling. While we showed previously that the RIIβ holoenzyme could undergo a single turnover autophosphorylation with adenosine triphosphate and magnesium (MgATP and trap both products in the crystal lattice, we asked here whether calcium could trap an ATP:RIIβ holoenzyme since the RIIβ holoenzyme is located close to ion channels. The 2.8Å structure of an RIIβp2:C2:(Ca2ADP2 holoenzyme, supported by biochemical and biophysical data, reveals a trapped single phosphorylation event similar to MgATP. Thus, calcium can mediate a single turnover event with either ATP or adenosine-5'-(β,γ-imidotriphosphate (AMP-PNP, even though it cannot support steady-state catalysis efficiently. The holoenzyme serves as a "product trap" because of the slow off-rate of the pRIIβ subunit, which is controlled by cAMP, not by phosphorylation of the inhibitor site. By quantitatively defining the RIIβ signaling cycle, we show that release of pRIIβ in the presence of cAMP is reduced by calcium, whereas autophosphorylation at the phosphorylation site (P-site inhibits holoenzyme reassociation with the catalytic subunit. Adding a single phosphoryl group to the preformed RIIβ holoenzyme thus creates a signaling cycle in which phosphatases become an essential partner. This previously unappreciated molecular mechanism is an integral part of PKA signaling for type II holoenzymes.

  10. Single stage to orbit mass budgets derived from propellant density and specific impulse

    Energy Technology Data Exchange (ETDEWEB)

    Whitehead, J.C.


    The trade between specific impulse (Isp) and density is examined in view of Single Stage To Orbit (SSTO) requirements. Mass allocations for vehicle hardware are derived from these two properties, for several propellant combinations and a dual-fuel case. This comparative analysis, based on flight-proven hardware, indicates that the higher density of several alternative propellants compensates for reduced Isp, when compared with cryogenic oxygen and hydrogen. Approximately half the orbiting mass of a rocket- propelled SSTO vehicle must be allocated to propulsion hardware and residuals. Using hydrogen as the only fuel requires a slightly greater fraction of orbiting mass for propulsion, because hydrogen engines and tanks are heavier than those for denser fuels. The advantage of burning both a dense fuel and hydrogen in succession depends strongly on tripropellant engine weight. The implications of the calculations for SSTO vehicle design are discussed, especially with regard to the necessity to minimize non-tankage structure.

  11. A new seniority scheme for non-degenerate single particle orbits

    International Nuclear Information System (INIS)

    Otsuka, T.; Arima, A.


    A new method is proposed in the treatment of the seniority scheme. The method enables one to evaluate analytically the contribution from J = 0 Cooper pairs in non-degenerate single-particle orbits to many-body matrix elements. It includes the SU(2) quasi-spin and the BCS approximation as two extreme limits. The effect of particle number conservation is properly taken into account. (Auth.)

  12. Orbital control of western North America atmospheric circulation and climate over two glacial cycles. (United States)

    Lachniet, Matthew S; Denniston, Rhawn F; Asmerom, Yemane; Polyak, Victor J


    The now arid Great Basin of western North America hosted expansive late Quaternary pluvial lakes, yet the climate forcings that sustained large ice age hydrologic variations remain controversial. Here we present a 175,000 year oxygen isotope record from precisely-dated speleothems that documents a previously unrecognized and highly sensitive link between Great Basin climate and orbital forcing. Our data match the phasing and amplitudes of 65°N summer insolation, including the classic saw-tooth pattern of global ice volume and on-time terminations. Together with the observation of cold conditions during the marine isotope substage 5d glacial inception, our data document a strong precessional-scale Milankovitch forcing of southwestern paleoclimate. Because the expansion of pluvial lakes was associated with cold glacial conditions, the reappearance of large lakes in the Great Basin is unlikely until ca. 55,000 years into the future as climate remains in a mild non-glacial state over the next half eccentricity cycle.

  13. Coarse Initial Orbit Determination for a Geostationary Satellite Using Single-Epoch GPS Measurements

    Directory of Open Access Journals (Sweden)

    Ghangho Kim


    Full Text Available A practical algorithm is proposed for determining the orbit of a geostationary orbit (GEO satellite using single-epoch measurements from a Global Positioning System (GPS receiver under the sparse visibility of the GPS satellites. The algorithm uses three components of a state vector to determine the satellite’s state, even when it is impossible to apply the classical single-point solutions (SPS. Through consideration of the characteristics of the GEO orbital elements and GPS measurements, the components of the state vector are reduced to three. However, the algorithm remains sufficiently accurate for a GEO satellite. The developed algorithm was tested on simulated measurements from two or three GPS satellites, and the calculated maximum position error was found to be less than approximately 40 km or even several kilometers within the geometric range, even when the classical SPS solution was unattainable. In addition, extended Kalman filter (EKF tests of a GEO satellite with the estimated initial state were performed to validate the algorithm. In the EKF, a reliable dynamic model was adapted to reduce the probability of divergence that can be caused by large errors in the initial state.

  14. High Cycle Life, Low Temperature Lithium Ion Battery for Earth Orbiting and Planetary Missions Project (United States)

    National Aeronautics and Space Administration — NASA requires development of advanced rechargeable electrochemical battery systems for lithium ion batteries to support orbiting spacecraft and planetary missions....

  15. Direct and enantioselective α-allylation of ketones via singly occupied molecular orbital (SOMO) catalysis (United States)

    Mastracchio, Anthony; Warkentin, Alexander A.; Walji, Abbas M.; MacMillan, David W. C.


    The first enantioselective organocatalytic α-allylation of cyclic ketones has been accomplished via singly occupied molecular orbital catalysis. Geometrically constrained radical cations, forged from the one-electron oxidation of transiently generated enamines, readily undergo allylic alkylation with a variety of commercially available allyl silanes. A reasonable latitude in both the ketone and allyl silane components is readily accommodated in this new transformation. Moreover, three new oxidatively stable imidazolidinone catalysts have been developed that allow cyclic ketones to successfully participate in this transformation. The new catalyst platform has also been exploited in the first catalytic enantioselective α-enolation and α-carbooxidation of ketones. PMID:20921367

  16. A single stage to orbit rocket with non-cryogenic propellants (United States)

    Clapp, Mitchell B.; Hunter, Maxwell W.


    Different propellant combinations for single-stage-to-orbit-rocket applications were compared to oxygen/hydrogen, including nitrogen tetroxide/hydrazine, oxygen/methane, oxygen/propane, oxygen/RP-1, solid core nuclear/hydrogen, and hydrogen peroxide/JP-5. Results show that hydrogen peroxide and JP-5, which have a specific impulse of 328 s in vacuum and a density of 1,330 kg/cu m. This high-density jet fuel offers 1.79 times the payload specific energy of oxygen and hydrogen. By catalytically decomposing the hydrogen peroxide to steam and oxygen before injection into the thrust chamber, the JP-5 can be injected as a liquid into a high-temperature gas flow. This would yield superior combustion stability and permit easy throttling of the engine by adjusting the amount of JP-5 in the mixture. It is concluded that development of modern hydrogen peroxide/JP-5 engines, combined with modern structural technology, could lead to a simple, robust, and versatile single-stage-to-orbit capability.

  17. Simulation of the synergistic low Earth orbit effects of vacuum thermal cycling, vacuum UV radiation, and atomic oxygen (United States)

    Dever, Joyce A.; Degroh, Kim K.; Stidham, Curtis R.; Stueber, Thomas J.; Dever, Therese M.; Rodriguez, Elvin; Terlep, Judith A.


    In order to assess the low Earth orbit (LEO) durability of candidate space materials, it is necessary to use ground laboratory facilities which provide LEO environmental effects. A facility combining vacuum thermal cycling and vacuum ultraviolet (VUV) radiation has been designed and constructed at NASA Lewis Research Center for this purpose. This facility can also be operated without the VUV lamps. An additional facility can be used to provide VUV exposure only. By utilizing these facilities, followed by atomic oxygen exposure in an RF plasma asher, the effects of the individual vacuum thermal cycling and VUV environments can be compared to the effect of the combined vacuum thermal cycling/VUV environment on the atomic oxygen durability of materials. The synergistic effects of simulated LEO environmental conditions on materials were evaluated by first exposing materials to vacuum thermal cycling, VUV, and vacuum thermal cycling/VUV environments followed by exposure to atomic oxygen in an RP plasma asher. Candidate space power materials such as atomic oxygen protected polyimides and solar concentrator mirrors were evaluated using these facilities. Characteristics of the Vacuum Thermal Cycling/VUV Exposure Facility which simulates the temperature sequences and solar ultraviolet radiation exposure that would be experienced by a spacecraft surface in LEO are discussed. Results of durability evaluations of some candidate space power materials to the simulated LEO environmental conditions will also be discussed. Such results have indicated that for some materials, atomic oxygen durability is affected by previous exposure to thermal cycling and/or VUV exposure.

  18. Nonlinear pulse propagation in a single-and a few-cycle regimes ...

    Indian Academy of Sciences (India)

    The propagation equation for a single- and a few-cycle pulses was derived in a cubic nonlinear medium including the Raman response. Using this equation, the propagation characteristics of a single- and a 4-cycle pulse, at 0.8 m wavelength, were studied numerically in one spatial dimension. It was shown that Raman ...

  19. Critical hand ischemia treatment via orbital atherectomy-A single center observational retrospective analysis. (United States)

    Bahro, Abdul; Igyarto, Zsuzsanna; Martinsen, Brad


    Critical hand ischemia (CHI) can be devastating and may result in amputation. Distal vessel calcification has been shown to be a major factor in causing CHI. Atherectomy in the upper extremities is not typically considered due to the small anatomy; however, the Diamondback 360° Peripheral Orbital Atherectomy System (OAS) (Cardiovascular Systems, Inc.) can access treatment areas with a reference vessel diameter of 1.5mm. A retrospective, observational, single center (Merit Health Center, Jackson, MS) analysis of 11 CHI patients with calcific disease of the radial artery treated with orbital atherectomy (OAS) was completed. Demographics and procedural to 30-day outcomes were assessed. All patients had good blood flow to the hand after intervention and none experienced complications during or immediately post-procedure. At 30-days the freedom from revascularization and amputation was 100%, and all the wounds were healed. The following important principles were followed during the use of OAS for CHI: (1) ACT was therapeutic (~250s); (2) Gentle wire manipulation; (3) Utilization of a small OAS crown (1.25mm); (4) Aggressive vasodilator use-given through the exchange catheter; (5) Angioplasty balloon was matched to the size of the vessel and long and low pressure inflations were completed. Critical hand ischemia can be treated with endovascular techniques. Obtaining good outflow to the fingers is critical for wound healing and preventing amputation. Orbital atherectomy is a useful tool in preparing vessels for balloon angioplasty; particularly in cases where calcification is present. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  20. Effect of quenched disorder on charge-orbital-spin ordering in single-layer manganites

    International Nuclear Information System (INIS)

    Uchida, Masaya; Mathieu, Roland; He, Jinping; Kaneko, Yoshio; Tokura, Yoshinori; Asamitsu, Atsushi; Kumai, Reiji; Tomioka, Yasuhide; Matsui, Yoshio


    Structural and magnetic properties have been investigated for half-doped single-layer manganites RE 0.5 Sr 1.5 MnO 4 [RE=La, (La, Pr), Pr, Nd, Sm, and Eu]. Analyses of electron diffraction and ac susceptibility measurements have revealed that the long-range charge-orbital ordering (CO-OO) state as observed in La 0.5 Sr 1.5 MnO 4 is suppressed for the other materials: the CO-OO transition temperature, as well as the correlation length decreases with a decrease in the cation size of RE. Such a short-range CO-OO state shows a spin-glass behavior at low temperatures. A new electronic phase diagram is established with quenched disorder as the control parameter. (author)

  1. Degradation of geopotential recovery from short repeat-cycle orbits: application to GRACE monthly fields

    Czech Academy of Sciences Publication Activity Database

    Wagner, C.; McAdoo, D.; Klokočník, Jaroslav; Kostelecký, J.


    Roč. 80, č. 2 (2006), s. 94-103 ISSN 0949-7714 R&D Projects: GA AV ČR IAA3003407 Institutional research plan: CEZ:AV0Z10030501 Keywords : geopotential resolution * repeat orbits * resonances Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 1.210, year: 2006

  2. Design and analysis of a single stage to orbit nuclear thermal rocket reactor engine

    Energy Technology Data Exchange (ETDEWEB)

    Labib, Satira, E-mail:; King, Jeffrey, E-mail:


    Graphical abstract: - Highlights: • Three NTR reactors are optimized for the single stage launch of 1–15 MT payloads. • The proposed rocket engines have specific impulses in excess of 700 s. • Reactivity and submersion criticality requirements are satisfied for each reactor. - Abstract: Recent advances in the development of high power density fuel materials have renewed interest in nuclear thermal rockets (NTRs) as a viable propulsion technology for future space exploration. This paper describes the design of three NTR reactor engines designed for the single stage to orbit launch of payloads from 1 to 15 metric tons. Thermal hydraulic and rocket engine analyses indicate that the proposed rocket engines are able to reach specific impulses in excess of 800 s. Neutronics analyses performed using MCNP5 demonstrate that the hot excess reactivity, shutdown margin, and submersion criticality requirements are satisfied for each NTR reactor. The reactors each consist of a 40 cm diameter core packed with hexagonal tungsten cermet fuel elements. The core is surrounded by radial and axial beryllium reflectors and eight boron carbide control drums. The 40 cm long reactor meets the submersion criticality requirements (a shutdown margin of at least $1 subcritical in all submersion scenarios) with no further modifications. The 80 and 120 cm long reactors include small amounts of gadolinium nitride as a spectral shift absorber to keep them subcritical upon submersion in seawater or wet sand following a launch abort.

  3. Efficiency of single-family houses and harmonisation of their life cycle participants’ interests

    Directory of Open Access Journals (Sweden)

    Nerija Kvederyte


    Full Text Available An efficient single-family house is the main purpose of the life cycle. It determines the necessity to evaluate various decisions of the life cycle of single-family houses and possibilities to satisfy objectives and requirements of the participants of that process. To design and achieve an effective process of the life cycle of a single-family house, it is necessary to take care of its efficiency starting from the determination of needs and objectives and ending with the usage of a building.

  4. Development of a Hemispherical Metal Diaphragm for Single-Cycle Liquid-Metal Positive Expulsion Systems

    National Research Council Canada - National Science Library

    Gorland, Sol


    This report presents experimental results pertaining to the design and development of a metallic expulsion diaphragm for single-cycle positive expulsion of high-temperature liquid in an agravity condition...

  5. Orbital Signals in Carbon Isotopes: Phase Distortion as a Signature of the Carbon Cycle (United States)

    Laurin, Jiří; Rąžek, Bohuslav; Giorgioni, Martino


    Isotopic mass balance models are employed here to study the response of carbon isotope composition (δ13C) of the ocean-atmosphere system to amplitude-modulated perturbations on Milankovitch time scales. We identify a systematic phase distortion, which is inherent to a leakage of power from the carrier precessional signal to the modulating eccentricity terms in the global carbon cycle. The origin is partly analogous to the simple cumulative effect in sinusoidal signals, reflecting the residence time of carbon in the ocean-atmosphere reservoir. The details of origin and practical implications are, however, different. In amplitude-modulated signals, the deformation is manifested as a lag of the 405 kyr eccentricity cycle behind amplitude modulation (AM) of the short ( 100 kyr) eccentricity cycle. Importantly, the phase of AM remains stable during the carbon cycle transfer, thus providing a reference framework against which to evaluate distortion of the 405 kyr term. The phase relationships can help to (1) identify depositional and diagenetic signatures in δ13C and (2) interpret the pathways of astronomical signal through the climate system. The approach is illustrated by case studies of Albian and Oligocene records using a new computational tool EPNOSE (Evaluation of Phase in uNcertain and nOisy SEries). Analogous phase distortions occur in other components of the carbon cycle including atmospheric CO2 levels; hence, to fully understand the causal relationships on astronomical time scales, paleoclimate models may need to incorporate realistic, amplitude-modulated insolation instead of monochromatic sinusoidal approximations. Finally, detection of the lagged δ13C response can help to reduce uncertainties in astrochronological age models that are tuned to the 405 kyr cycle.

  6. Analysis of changes in paper cutting forces during the cutting cycle in single-knife guillotine


    Rusin, Agnieszka; Petriaszwili, Georgij


    Paper presents the results of changes in the three components of cutting forces of paper stacks cutting during the cutting cycle in single-knife guillotine. The changes of the three components of cutting force at different stages of cutting cycle were analyzed.

  7. Millennial cycles of mean sea level excited by earth´s orbital variations

    Czech Academy of Sciences Publication Activity Database

    Chapanov, Y.; Ron, Cyril; Vondrák, Jan


    Roč. 12, č. 3 (2015), s. 259-266 ISSN 1214-9705 R&D Projects: GA ČR GA13-15943S Institutional support: RVO:67985815 Keywords : millenial cycles * mean sea level * Earth's insolation Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 0.561, year: 2015

  8. Orbital signals in carbon isotopes: phase distortion as a signature of the carbon cycle

    Czech Academy of Sciences Publication Activity Database

    Laurin, Jiří; Růžek, Bohuslav; Giorgioni, M.


    Roč. 32, č. 11 (2017), s. 1236-1255 ISSN 0883-8305 R&D Projects: GA ČR GA17-10982S Institutional support: RVO:67985530 Keywords : Eocene thermal maximum * global warming events * Milankovitch cycles Subject RIV: DB - Geology ; Mineralogy OBOR OECD: Geology Impact factor: 3.254, year: 2016

  9. The Plio-Pleistocene climatic evolution as a consequence of orbital forcing on the carbon cycle (United States)

    Paillard, Didier


    Since the discovery of ice ages in the 19th century, a central question of climate science has been to understand the respective role of the astronomical forcing and of greenhouse gases, in particular changes in the atmospheric concentration of carbon dioxide. Glacial-interglacial cycles have been shown to be paced by the astronomy with a dominant periodicity of 100 ka over the last million years, and a periodicity of 41 ka between roughly 1 and 3 million years before present (Myr BP). But the role and dynamics of the carbon cycle over the last 4 million years remain poorly understood. In particular, the transition into the Pleistocene about 2.8 Myr BP or the transition towards larger glaciations about 0.8 Myr BP (sometimes referred to as the mid-Pleistocene transition, or MPT) are not easily explained as direct consequences of the astronomical forcing. Some recent atmospheric CO2 reconstructions suggest slightly higher pCO2 levels before 1 Myr BP and a slow decrease over the last few million years (Bartoli et al., 2011; Seki et al., 2010). But the dynamics and the climatic role of the carbon cycle during the Plio-Pleistocene period remain unclear. Interestingly, the δ13C marine records provide some critical information on the evolution of sources and sinks of carbon. In particular, a clear 400 kyr oscillation has been found at many different time periods and appears to be a robust feature of the carbon cycle throughout at least the last 100 Myr (e.g. Paillard and Donnadieu, 2014). This oscillation is also visible over the last 4 Myr but its relationship with the eccentricity appears less obvious, with the occurrence of longer cycles at the end of the record, and a periodicity which therefore appears shifted towards 500 kyr (see Wang et al., 2004). In the following we present a simple dynamical model that provides an explanation for these carbon cycle variations, and how they relate to the climatic evolution over the last 4 Myr. It also gives an explanation for

  10. Single-neutron orbits near 78Ni: Spectroscopy of the N=49 isotope 79Zn

    Directory of Open Access Journals (Sweden)

    R. Orlandi


    Full Text Available Single-neutron states in the Z=30, N=49 isotope 79Zn have been populated using the 78Zn(d, p79Zn transfer reaction at REX-ISOLDE, CERN. The experimental setup allowed the combined detection of protons ejected in the reaction, and of γ rays emitted by 79Zn. The analysis reveals that the lowest excited states populated in the reaction lie at approximately 1 MeV of excitation, and involve neutron orbits above the N=50 shell gap. From the analysis of γ-ray data and of proton angular distributions, characteristic of the amount of angular momentum transferred, a 5/2+ configuration was assigned to a state at 983 keV. Comparison with large-scale-shell-model calculations supports a robust neutron N=50 shell-closure for 78Ni. These data constitute an important step towards the understanding of the magicity of 78Ni and of the structure of nuclei in the region.

  11. Imprints of Millennial and Orbital forcing of African climates over the last glacial cycle (United States)

    Farrow, Aidan; Singarayer, Joy; Burrough, Sallie; Bailey, Richard


    Paleoclimate records across Late Quaternary Africa reveal high amplitude variability between wet and dry conditions. There is abundant evidence that the extents of arid areas and lakes are not static and that during numerous incursions in the past the African continent has hosted vegetation, lakes and rivers not present today. The spatial distribution and timing of these humid arid transitions is complex. This work explores the possible orbital and millennial scale forcing mechanisms which may be involved in producing the complex patterns within our observations. African monsoon strength is determined by neighbouring sea surface temperatures and the cross continent temperature gradient. Over millennial and longer time scales these factors are controlled by orbital conditions but can also be affected by changes in the thermohaline circulation. Recent work has revealed apparent synchronicity between some lake high stand records and the timing of high latitude Heinrich events. For example lake highstands revealed by dated shoreline deposits from Lake Chilwa, southern Malawi, correlate with the high latitudes Heinrich events. In this work we ask if and where high latitude events impact African humidity. Specific attention is paid to South African records because their complexity suggest that different regions are sensitive to different forcings. We use a unique suite of equilibrium model simulations covering the last 140,000 years generated using the Hadley Centre model HadCM3. Comparison of possible forcing mechanisms is made against simulations of the 17, 24, 32, 38, 46 and 60 kyr B.P Heinrich events. Heinrich events were forced upon the model by initiating a fresh water pulse of 1 Sv across the region 50-70˚N in the Atlantic for 100 years of simulated time. This was sufficient to cause significant thermohaline circulation slowdown in the model and hence provides a mechanism for sea surface temperature change globally. We will show the effects of thermohaline

  12. Configuration interaction singles based on the real-space numerical grid method: Kohn-Sham versus Hartree-Fock orbitals. (United States)

    Kim, Jaewook; Hong, Kwangwoo; Choi, Sunghwan; Hwang, Sang-Yeon; Youn Kim, Woo


    We developed a program code of configuration interaction singles (CIS) based on a numerical grid method. We used Kohn-Sham (KS) as well as Hartree-Fock (HF) orbitals as a reference configuration and Lagrange-sinc functions as a basis set. Our calculations show that KS-CIS is more cost-effective and more accurate than HF-CIS. The former is due to the fact that the non-local HF exchange potential greatly reduces the sparsity of the Hamiltonian matrix in grid-based methods. The latter is because the energy gaps between KS occupied and virtual orbitals are already closer to vertical excitation energies and thus KS-CIS needs small corrections, whereas HF results in much larger energy gaps and more diffuse virtual orbitals. KS-CIS using the Lagrange-sinc basis set also shows a better or a similar accuracy to smaller orbital space compared to the standard HF-CIS using Gaussian basis sets. In particular, KS orbitals from an exact exchange potential by the Krieger-Li-Iafrate approximation lead to more accurate excitation energies than those from conventional (semi-) local exchange-correlation potentials.

  13. A proposal for the measurement of Rashba and Dresselhaus spin–orbit interaction strengths in a single sample

    International Nuclear Information System (INIS)

    Maiti, Santanu K.; Sil, Shreekantha; Chakrabarti, Arunava


    We establish an exact analytical treatment for the determination of the strengths of the Rashba and Dresselhaus spin–orbit interactions in a single sample by measuring persistent spin current. A hidden symmetry is exploited in the Hamiltonian to show that the spin current vanishes when the strength of the Dresselhaus interaction becomes equal to the strength of the Rashba term. The results are sustained even in the presence of disorder and thus an experiment in this regard will be challenging. -- Highlights: ► An exact analytical treatment is given for the measurement of spin–orbit interaction strengths in a single sample. ► Persistent spin current is calculated. ► Our present analysis gives us confidence to propose an experiment in this line.

  14. Latent Membrane Protein 1 as a molecular adjuvant for single-cycle lentiviral vaccines

    Directory of Open Access Journals (Sweden)

    Rahmberg Andrew R


    Full Text Available Abstract Background Molecular adjuvants are a promising method to enhance virus-specific immune responses and protect against HIV-1 infection. Immune activation by ligands for receptors such as CD40 can induce dendritic cell activation and maturation. Here we explore the incorporation of two CD40 mimics, Epstein Barr Virus gene LMP1 or an LMP1-CD40 chimera, into a strain of SIV that was engineered to be limited to a single cycle of infection. Results Full length LMP1 or the chimeric protein LMP1-CD40 was cloned into the nef-locus of single-cycle SIV. Human and Macaque monocyte derived macrophages and DC were infected with these viruses. Infected cells were analyzed for activation surface markers by flow cytometry. Cells were also analyzed for secretion of pro-inflammatory cytokines IL-1β, IL-6, IL-8, IL-12p70 and TNF by cytometric bead array. Conclusions Overall, single-cycle SIV expressing LMP1 and LMP1-CD40 produced a broad and potent TH1-biased immune response in human as well as rhesus macaque macrophages and DC when compared with control virus. Single-cycle SIV-LMP1 also enhanced antigen presentation by lentiviral vector vaccines, suggesting that LMP1-mediated immune activation may enhance lentiviral vector vaccines against HIV-1.

  15. Self-phase modulation of a single-cycle THz pulse

    DEFF Research Database (Denmark)

    Turchinovich, Dmitry; Hvam, Jørn Märcher; Hoffmann, M. C.


    We demonstrate self-phase modulation (SPM) of a single-cycle THz pulse in a semiconductor, using bulk n-GaAs as a model system. The SPM arises from the heating of free electrons in the electric field of the THz pulse. Electron heating leads to an ultrafast reduction of the plasma frequency, which...

  16. Orbit-related long-term climate cycles revealed in a 12-Myr continental record from Lake Baikal. (United States)

    Kashiwaya, K; Ochiai, S; Sakai, H; Kawai, T


    Quaternary records of climate change from terrestrial sources, such as lake sediments and aeolian sediments, in general agree well with marine records. But continuous records that cover more than the past one million years were essentially unavailable until recently, when the high-sedimentation-rate site of Lake Baikal was exploited. Because of its location in the middle latitudes, Lake Baikal is highly sensitive to insolation changes and the entire lake remained uncovered by ice sheets throughout the Pleistocene epoch, making it a valuable archive for past climate. Here we examine long sediment cores from Lake Baikal that cover the past 12 million years. Our record reveals a gradual cooling of the Asian continental interior, with some fluctuations. Spectral analyses reveal periods of about 400 kyr, 600 kyr and 1,000 kyr, which may correspond to Milankovitch periods (reflecting orbital cycles). Our results indicate that changes in insolation were closely related to long-term environmental variations in the deep continental interior, over the past 12 million years.

  17. The analysis of single-electron orbits in a free electron laser based upon a rectangular hybrid wiggler

    International Nuclear Information System (INIS)

    Kordbacheh, A.; Ghahremaninezhad, Roghayeh; Maraghechi, B.


    A three-dimensional analysis of a novel free-electron laser (FEL) based upon a rectangular hybrid wiggler (RHW) is presented. This RHW is designed in a configuration composed of rectangular rings with alternating ferrite and dielectric spacers immersed in a solenoidal magnetic field. An analytic model of RHW is introduced by solution of Laplace's equation for the magnetostatic fields under the appropriate boundary conditions. The single-electron orbits in combined RHW and axial guide magnetic fields are studied when only the first and the third spatial harmonic components of the RHW field are taken into account and the higher order terms are ignored. The results indicate that the third spatial harmonic leads to group III orbits with a strong negative mass regime particularly in large solenoidal magnetic fields. RHW is found to be a promising candidate with favorable characteristics to be used in microwave FEL.

  18. The analysis of single-electron orbits in a free electron laser based upon a rectangular hybrid wiggler (United States)

    Kordbacheh, A.; Ghahremaninezhad, Roghayeh; Maraghechi, B.


    A three-dimensional analysis of a novel free-electron laser (FEL) based upon a rectangular hybrid wiggler (RHW) is presented. This RHW is designed in a configuration composed of rectangular rings with alternating ferrite and dielectric spacers immersed in a solenoidal magnetic field. An analytic model of RHW is introduced by solution of Laplace's equation for the magnetostatic fields under the appropriate boundary conditions. The single-electron orbits in combined RHW and axial guide magnetic fields are studied when only the first and the third spatial harmonic components of the RHW field are taken into account and the higher order terms are ignored. The results indicate that the third spatial harmonic leads to group III orbits with a strong negative mass regime particularly in large solenoidal magnetic fields. RHW is found to be a promising candidate with favorable characteristics to be used in microwave FEL.

  19. Orbital free DFT versus single density equation: a perspective through quantum domain behavior of a classically chaotic system. (United States)

    Chakraborty, Debdutta; Kar, Susmita; Chattaraj, Pratim Kumar


    The orbital free density functional theory and the single density equation approach are formally equivalent. An orbital free density based quantum dynamical strategy is used to study the quantum-classical correspondence in both weakly and strongly coupled van der Pol and Duffing oscillators in the presence of an external electric field in one dimension. The resulting quantum hydrodynamic equations of motion are solved through an implicit Euler type real space method involving a moving weighted least square technique. The Lagrangian framework used here allows the numerical grid points to follow the wave packet trajectory. The associated classical equations of motion are solved using a sixth order Runge-Kutta method and the Ehrenfest dynamics is followed through the solution of the time dependent Schrodinger equation using a time dependent Fourier Grid Hamiltonian technique. Various diagnostics reveal a close parallelism between classical regular as well as chaotic dynamics and that obtained from the Bohmian mechanics.

  20. Redox cycling performance of inert-substrate-supported tubular single cells with nickel anode current collector (United States)

    Zhao, Kai; Kim, Bok-Hee; Xu, Qing; Du, Yanhai; Ahn, Byung-Guk


    An inert-substrate-supported tubular single cell, with a configuration of porous yttria-stabilized zirconia (YSZ) supporter/Ni anode current collector/Ni-Ce0.8Sm0.2O1.9 anode/YSZ/Ce0.8Sm0.2O1.9 bi-layer electrolyte/La0.6Sr0.4Co0.2Fe0.8O3-δ cathode, has been fabricated by extrusion and dip-coating techniques. Thickness of the Ni layer is modified by controlling the number of dip-coatings from one to four. Electrochemical performance and redox cycling stability of the single cell are investigated with respect to the microstructure of the Ni layer. Increasing the thickness of the Ni layer enhances the maximum power density of the cell, while it is unfavorable for the redox cycling stability. Considering the trade-off between these two aspects, an optimum dip-coating time is determined to be two. The cell shows a reasonable maximum power density of 453 mW cm-2 at 800 °C, as well as good redox cycling stability within eight redox cycles. Additionally, 10 vol.% Ce0.8Sm0.2O1.9 ceramic particle is incorporated into the Ni layer to further improve the redox cycling stability. The cell exhibits enhanced redox cycling performance after the Ce0.8Sm0.2O1.9 incorporation. Within seven redox cycles, the cell voltage loss is less than 1% at a current density of 400 mA cm-2, and it maintains 93% of its initial performance after 11 redox cycles.

  1. Mechanically Reconfigurable Single-Arm Spiral Antenna Array for Generation of Broadband Circularly Polarized Orbital Angular Momentum Vortex Waves. (United States)

    Li, Long; Zhou, Xiaoxiao


    In this paper, a mechanically reconfigurable circular array with single-arm spiral antennas (SASAs) is designed, fabricated, and experimentally demonstrated to generate broadband circularly polarized orbital angular momentum (OAM) vortex waves in radio frequency domain. With the symmetrical and broadband properties of single-arm spiral antennas, the vortex waves with different OAM modes can be mechanically reconfigurable generated in a wide band from 3.4 GHz to 4.7 GHz. The prototype of the circular array is proposed, conducted, and fabricated to validate the theoretical analysis. The simulated and experimental results verify that different OAM modes can be effectively generated by rotating the spiral arms of single-arm spiral antennas with corresponding degrees, which greatly simplify the feeding network. The proposed method paves a reconfigurable way to generate multiple OAM vortex waves with spin angular momentum (SAM) in radio and microwave satellite communication applications.

  2. Spin-orbit-induced strong coupling of a single spin to a nanomechanical resonator

    DEFF Research Database (Denmark)

    Pályi, András; Struck, P R; Rudner, Mark


    We theoretically investigate the deflection-induced coupling of an electron spin to vibrational motion due to spin-orbit coupling in suspended carbon nanotube quantum dots. Our estimates indicate that, with current capabilities, a quantum dot with an odd number of electrons can serve....... The strong intrinsic spin-mechanical coupling allows for detection, as well as manipulation of the spin qubit, and may yield enhanced performance of nanotubes in sensing applications....

  3. A Collaborative Analysis Tool for Integrating Hypersonic Aerodynamics, Thermal Protection Systems, and RBCC Engine Performance for Single Stage to Orbit Vehicles (United States)

    Stanley, Thomas Troy; Alexander, Reginald


    Presented is a computer-based tool that connects several disciplines that are needed in the complex and integrated design of high performance reusable single stage to orbit (SSTO) vehicles. Every system is linked to every other system, as is the case of SSTO vehicles with air breathing propulsion, which is currently being studied by NASA. The deficiencies in the scramjet powered concept led to a revival of interest in Rocket-Based Combined-Cycle (RBCC) propulsion systems. An RBCC propulsion system integrates airbreathing and rocket propulsion into a single engine assembly enclosed within a cowl or duct. A typical RBCC propulsion system operates as a ducted rocket up to approximately Mach 3. At this point the transitions to a ramjet mode for supersonic-to-hypersonic acceleration. Around Mach 8 the engine transitions to a scram4jet mode. During the ramjet and scramjet modes, the integral rockets operate as fuel injectors. Around Mach 10-12 (the actual value depends on vehicle and mission requirements), the inlet is physically closed and the engine transitions to an integral rocket mode for orbit insertion. A common feature of RBCC propelled vehicles is the high degree of integration between the propulsion system and airframe. At high speeds the vehicle forebody is fundamentally part of the engine inlet, providing a compression surface for air flowing into the engine. The compressed air is mixed with fuel and burned. The combusted mixture must be expanded to an area larger than the incoming stream to provide thrust. Since a conventional nozzle would be too large, the entire lower after body of the vehicle is used as an expansion surface. Because of the high external temperatures seen during atmospheric flight, the design of an airbreathing SSTO vehicle requires delicate tradeoffs between engine design, vehicle shape, and thermal protection system (TPS) sizing in order to produce an optimum system in terms of weight (and cost) and maximum performance.

  4. ERS orbit control (United States)

    Rosengren, Mats


    The European remote sensing mission orbit control is addressed. For the commissioning phase, the orbit is defined by the following requirements: Sun synchronous, local time of descending node 10:30; three days repeat cycle with 43 orbital revolutions; overhead Venice tower (12.508206 deg east, 45.314222 deg north). The launch, maneuvers for the initial acquisition of the operational orbit, orbit maintenance maneuvers, evaluation of the orbit control, and the drift of the inclination are summarized.

  5. Nonlinear pulse propagation in a single- and a few-cycle regimes ...

    Indian Academy of Sciences (India)

    In this work, we study the effect of the delayed nonlinear response (intrapulse. Raman effect) on the propagation characteristics of a single- and a few-cycle pulse at 0.8 µm wavelength in a silica glass ..... 0.03923 fs2/µm, Tr = 3 fs and σ = 0.7. effect leads to a frequency shift toward higher frequencies, in the trailing edge and.

  6. A fully three-dimensional reconstruction algorithm with the nonstationary filter for improved single-orbit cone beam SPECT

    International Nuclear Information System (INIS)

    Cao, Z.J.; Tsui, B.M.


    Conventional single-orbit cone beam tomography presents special problems. They include incomplete sampling and inadequate three-dimensional (3D) reconstruction algorithm. The commonly used Feldkamp reconstruction algorithm simply extends the two-dimensional (2D) fan beam algorithm to 3D cone beam geometry. A truly 3D reconstruction formulation has been derived for the single-orbit cone beam SPECT based on the 3D Fourier slice theorem. In the formulation, a nonstationary filter which depends on the distance from the central plane of the cone beam was derived. The filter is applied to the 2D projection data in directions along and normal to the axis-of-rotation. The 3D reconstruction algorithm with the nonstationary filter was evaluated using both computer simulation and experimental measurements. Significant improvement in image quality was demonstrated in terms of decreased artifacts and distortions in cone beam reconstructed images. However, compared with the Feldkamp algorithm, a five-fold increase in processing time is required. Further improvement in image quality needs complete sampling in frequency space

  7. Robust synchronization of coupled circadian and cell cycle oscillators in single mammalian cells (United States)

    Bieler, Jonathan; Cannavo, Rosamaria; Gustafson, Kyle; Gobet, Cedric; Gatfield, David; Naef, Felix


    Circadian cycles and cell cycles are two fundamental periodic processes with a period in the range of 1 day. Consequently, coupling between such cycles can lead to synchronization. Here, we estimated the mutual interactions between the two oscillators by time-lapse imaging of single mammalian NIH3T3 fibroblasts during several days. The analysis of thousands of circadian cycles in dividing cells clearly indicated that both oscillators tick in a 1:1 mode-locked state, with cell divisions occurring tightly 5 h before the peak in circadian Rev-Erbα-YFP reporter expression. In principle, such synchrony may be caused by either unidirectional or bidirectional coupling. While gating of cell division by the circadian cycle has been most studied, our data combined with stochastic modeling unambiguously show that the reverse coupling is predominant in NIH3T3 cells. Moreover, temperature, genetic, and pharmacological perturbations showed that the two interacting cellular oscillators adopt a synchronized state that is highly robust over a wide range of parameters. These findings have implications for circadian function in proliferative tissues, including epidermis, immune cells, and cancer. PMID:25028488

  8. Active and Inactive Leg Hemodynamics during Sequential Single-Leg Interval Cycling. (United States)

    Gordon, Nicole; Abbiss, Chris R; Ihsan, Mohammed; Maiorana, Andrew J; Peiffer, Jeremiah J


    Leg order during sequential single-leg cycling (i.e. exercising both legs independently within a single session) may affect local muscular responses potentially influencing adaptations. This study examined the cardiovascular and skeletal muscle hemodynamic responses during double-leg and sequential single-leg cycling. Ten young healthy adults (28 ± 6 y) completed six 1-min double-leg intervals interspersed with one minute of passive recovery and, on a separate occasion, 12 (six with one leg followed by six with the other leg) 1-min single-leg intervals interspersed with one minute of passive recovery. Oxygen consumption, heart rate, blood pressure, muscle oxygenation, muscle blood volume and power output were measured throughout each session. Oxygen consumption, heart rate and power output were not different between sets of single-leg intervals but the average of both sets was lower than the double-leg intervals. Mean arterial pressure was higher during double-leg compared with sequential single-leg intervals (115 ± 9 mmHg vs. 104 ± 9 mmHg; p<0.05) and higher during the initial compared with second set of single-leg intervals (108 ± 10 mmHg vs. 101 ± 10 mmHg; p<0.05). The increase in muscle blood volume from baseline was similar between the active single-leg and double-leg (267 ± 150 μM[BULLET OPERATOR]cm vs. 214 ± 169 μM[BULLET OPERATOR]cm; p=0.26). The pattern of change in muscle blood volume from the initial to second set of intervals was significantly different (p<0.05) when the leg was active in the initial (-52.3 ± 111.6%) compared with second set (65.1 ± 152.9%). These data indicate that the order in which each leg performs sequential single-leg cycling influences the local hemodynamic responses, with the inactive muscle influencing the stimulus experienced by the contralateral leg.

  9. Thermodynamic analysis of single-stage and multi-stage adsorption refrigeration cycles with activated carbon–ammonia working pair

    International Nuclear Information System (INIS)

    Xu, S.Z.; Wang, L.W.; Wang, R.Z.


    Highlights: • Activated carbon–ammonia multi-stage adsorption refrigerator was analyzed. • COP, exergetic efficiency and entropy production of cycles were calculated. • Single-stage cycle usually has the advantages of simple structure and high COP. • Multi-stage cycles adapt to critical conditions better than single-stage cycle. • Boundary conditions for choosing optimal cycle were summarized as tables. - Abstract: Activated carbon–ammonia multi-stage adsorption refrigeration cycle was analyzed in this article, which realized deep-freezing for evaporating temperature under −18 °C with heating source temperature much lower than 100 °C. Cycle mathematical models for single, two and three-stage cycles were established on the basis of thorough thermodynamic analysis. According to simulation results of thermodynamic evaluation indicators such as COP (coefficient of performance), exergetic efficiency and cycle entropy production, multi-stage cycle adapts to high condensing temperature, low evaporating temperature and low heating source temperature well. Proposed cycle with selected working pair can theoretically work under very severe conditions, such as −25 °C evaporating temperature, 40 °C condensing temperature, and 70 °C heating source temperature, but under these working conditions it has the drawback of low cycle adsorption quantity. It was found that both COP and exergetic efficiency are of great reference value in the choice of cycle, whereas entropy production is not so useful for cycle stage selection. Finally, the application boundary conditions of single-stage, two-stage, and three-stage cycles were summarized as tables according to the simulation results, which provides reference for choosing optimal cycle under different conditions.

  10. Single-cell paired-end genome sequencing reveals structural variation per cell cycle (United States)

    Voet, Thierry; Kumar, Parveen; Van Loo, Peter; Cooke, Susanna L.; Marshall, John; Lin, Meng-Lay; Zamani Esteki, Masoud; Van der Aa, Niels; Mateiu, Ligia; McBride, David J.; Bignell, Graham R.; McLaren, Stuart; Teague, Jon; Butler, Adam; Raine, Keiran; Stebbings, Lucy A.; Quail, Michael A.; D’Hooghe, Thomas; Moreau, Yves; Futreal, P. Andrew; Stratton, Michael R.; Vermeesch, Joris R.; Campbell, Peter J.


    The nature and pace of genome mutation is largely unknown. Because standard methods sequence DNA from populations of cells, the genetic composition of individual cells is lost, de novo mutations in cells are concealed within the bulk signal and per cell cycle mutation rates and mechanisms remain elusive. Although single-cell genome analyses could resolve these problems, such analyses are error-prone because of whole-genome amplification (WGA) artefacts and are limited in the types of DNA mutation that can be discerned. We developed methods for paired-end sequence analysis of single-cell WGA products that enable (i) detecting multiple classes of DNA mutation, (ii) distinguishing DNA copy number changes from allelic WGA-amplification artefacts by the discovery of matching aberrantly mapping read pairs among the surfeit of paired-end WGA and mapping artefacts and (iii) delineating the break points and architecture of structural variants. By applying the methods, we capture DNA copy number changes acquired over one cell cycle in breast cancer cells and in blastomeres derived from a human zygote after in vitro fertilization. Furthermore, we were able to discover and fine-map a heritable inter-chromosomal rearrangement t(1;16)(p36;p12) by sequencing a single blastomere. The methods will expedite applications in basic genome research and provide a stepping stone to novel approaches for clinical genetic diagnosis. PMID:23630320

  11. A Rocket Powered Single-Stage-to-Orbit Launch Vehicle With U.S. and Soviet Engineers (United States)

    MacConochie, Ian O.; Stnaley, Douglas O.


    A single-stage-to-orbit launch vehicle is used to assess the applicability of Soviet Energia high-pressure-hydrocarbon engine to advanced U.S. manned space transportation systems. Two of the Soviet engines are used with three Space Shuttle Main Engines. When applied to a baseline vehicle that utilized advanced hydrocarbon engines, the higher weight of the Soviet engines resulted in a 20 percent loss of payload capability and necessitated a change in the crew compartment size and location from mid-body to forebody in order to balance the vehicle. Various combinations of Soviet and Shuttle engines were evaluated for comparison purposes, including an all hydrogen system using all Space Shuttle Main Engines. Operational aspects of the baseline vehicle are also discussed. A new mass properties program entitles Weights and Moments of Inertia (WAMI) is used in the study.

  12. A rapid method for optimization of the rocket propulsion system for single-stage-to-orbit vehicles (United States)

    Eldred, C. H.; Gordon, S. V.


    A rapid analytical method for the optimization of rocket propulsion systems is presented for a vertical take-off, horizontal landing, single-stage-to-orbit launch vehicle. This method utilizes trade-offs between propulsion characteristics affecting flight performance and engine system mass. The performance results from a point-mass trajectory optimization program are combined with a linearized sizing program to establish vehicle sizing trends caused by propulsion system variations. The linearized sizing technique was developed for the class of vehicle systems studied herein. The specific examples treated are the optimization of nozzle expansion ratio and lift-off thrust-to-weight ratio to achieve either minimum gross mass or minimum dry mass. Assumed propulsion system characteristics are high chamber pressure, liquid oxygen and liquid hydrogen propellants, conventional bell nozzles, and the same fixed nozzle expansion ratio for all engines on a vehicle.

  13. Failure of single electron descriptions of molecular orbital collision processes. [Electron promotion mechanism

    Energy Technology Data Exchange (ETDEWEB)

    Elston, S.B.


    Inner-shell excitation occurring in low and moderate (keV range) energy collisions between light atomic and ionic systems is frequently describable in terms of molecular promotion mechanisms, which were extensively explored both theoretically and experimentally. The bulk of such studies have concentrated on processes understandable through the use of single- and independent-electron models. Nonetheless, it is possible to find cases of inner-shell excitation in relatively simple collision systems which involve nearly simultaneous multiple-electron transitions and transitions induced by inherently two-electron interactions. Evidence for these many- and nonindependent-electron phenomena in inner-shell excitation processes and the importance of considering such effects in the interpretation of collisionally induced excitation spectra is discussed. 13 references.

  14. Mitochondrial specialization revealed by single muscle fiber proteomics: focus on the Krebs cycle. (United States)

    Schiaffino, S; Reggiani, C; Kostrominova, T Y; Mann, M; Murgia, M


    We have developed a highly sensitive mass spectrometry-based proteomic workflow to examine the proteome of single muscle fibers. This study revealed significant differences in the mitochondrial proteome of the four major fiber types present in mouse skeletal muscle. Here, we focus on Krebs cycle enzymes and in particular on the differential distribution of the two mitochondrial isocitrate dehydrogenases, IDH2 and IDH3. Type 1/slow fibers contain high levels of IDH2 and relatively low levels of IDH3, whereas fast 2X and 2B fibers show an opposite expression pattern. The findings suggest that in skeletal muscle, IDH2 functions in the forward direction of the Krebs cycle and that substrate flux along the cycle occurs predominantly via IDH2 in type 1 fibers and via IDH3 in 2X and 2B fibers. IDH2-mediated conversion of isocitrate to α-ketoglutarate leads to the generation of NADPH, which is critical to buffering the H2O2 produced by the respiratory chain. Nicotinamide nucleotide transhydrogenase (NNT), the other major mitochondrial enzyme involved in NADPH generation, is also more abundant in type 1 fibers. We suggest that the continuously active type 1 fibers are endowed with a more efficient H2O2 scavenging capacity to cope with the higher levels of reactive oxygen species production. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  15. Separation of Minor Actinides by a Single Cycle Approach using Unsymmetrical Diglycolamide and Diglycolamic Acid

    International Nuclear Information System (INIS)

    Kumaresan, R.; Nayak, P.K.; Venkatesan, K.A.; Prathibha, T.; Rajeswari, S.; Antony, M.P.; Vasudeva Rao, P.R.


    A new class of CHON-extractants, namely unsymmetrical diglycol-amides (UDGA) and diglycolamic acid were developed for the partitioning of minor actinides from high level liquid waste. Group separation of trivalent metal ions (An(III) + Ln(III)) from fast reactor (FR) simulated high-level liquid waste (SHLLW) was demonstrated using UDGA, N,N,-didodecyl-N',N'-dioctyl-3-oxapentane-1,5-diamide (D 3 DODGA)without the addition of organic phase modifier in n-dodecane phase. A single-cycle approach has been explored for the separation of trivalent actinides from FR-SHLLW using the solvent phase composed of D 3 DODGA and di-2-ethylhexyl-diglycolamic acid (HDEHDGA), or tetra-bis(2-ethylhexyl)diglycolamide (TEHDGA) and bis(2-ethylhexyl)phosphoric acid(HDEHP). A procedure was developed to minimise the extraction of unwanted metal ions by using aqueous soluble complexing agents in FR-SHLLW. Based on the optimised conditions, a counter current mixer-settler run was performed to separate Am(III) from FR-SHLLW using a novel ejector based mixer-settler. Quantitative extraction of trivalent (Am(III) + Ln(III)) was observed in both the systems. Am(III) alone was back extracted from loaded organic phase using a solution of diethylenetriaminepentaacetic acid - citric acid. The results showed the possibility of selective separation of trivalent actinides alone from high level liquid waste in a single cycle process. (authors)

  16. Single Event Upset Analysis: On-orbit performance of the Alpha Magnetic Spectrometer Digital Signal Processor Memory aboard the International Space Station (United States)

    Li, Jiaqiang; Choutko, Vitaly; Xiao, Liyi


    Based on the collection of error data from the Alpha Magnetic Spectrometer (AMS) Digital Signal Processors (DSP), on-orbit Single Event Upsets (SEUs) of the DSP program memory are analyzed. The daily error distribution and time intervals between errors are calculated to evaluate the reliability of the system. The particle density distribution of International Space Station (ISS) orbit is presented and the effects from the South Atlantic Anomaly (SAA) and the geomagnetic poles are analyzed. The impact of solar events on the DSP program memory is carried out combining data analysis and Monte Carlo simulation (MC). From the analysis and simulation results, it is concluded that the area corresponding to the SAA is the main source of errors on the ISS orbit. Solar events can also cause errors on DSP program memory, but the effect depends on the on-orbit particle density.

  17. Predicting the Size of Sunspot Cycle 24 on the Basis of Single- and Bi-Variate Geomagnetic Precursor Methods (United States)

    Wilson, Robert M.; Hathaway, David H.


    Examined are single- and bi-variate geomagnetic precursors for predicting the maximum amplitude (RM) of a sunspot cycle several years in advance. The best single-variate fit is one based on the average of the ap index 36 mo prior to cycle minimum occurrence (E(Rm)), having a coefficient of correlation (r) equal to 0.97 and a standard error of estimate (se) equal to 9.3. Presuming cycle 24 not to be a statistical outlier and its minimum in March 2008, the fit suggests cycle 24 s RM to be about 69 +/- 20 (the 90% prediction interval). The weighted mean prediction of 11 statistically important single-variate fits is 116 +/- 34. The best bi-variate fit is one based on the maximum and minimum values of the 12-mma of the ap index; i.e., APM# and APm*, where # means the value post-E(RM) for the preceding cycle and * means the value in the vicinity of cycle minimum, having r = 0.98 and se = 8.2. It predicts cycle 24 s RM to be about 92 +/- 27. The weighted mean prediction of 22 statistically important bi-variate fits is 112 32. Thus, cycle 24's RM is expected to lie somewhere within the range of about 82 to 144. Also examined are the late-cycle 23 behaviors of geomagnetic indices and solar wind velocity in comparison to the mean behaviors of cycles 2023 and the geomagnetic indices of cycle 14 (RM = 64.2), the weakest sunspot cycle of the modern era.

  18. Excitation of random intense single-cycle light-pulse chains in optical fiber

    International Nuclear Information System (INIS)

    Ding, Y C; Zhang, F L; Gao, J B; Chen, Z Y; Lin, C Y; Yu, M Y


    Excitation of intense periodic single-cycle light pulses in a stochastic background arising from continuous wave stimulated Brillouin scattering (SBS) in a long optical fiber with weak optical feedback is found experimentally and modeled theoretically. Such intense light-pulse chains occur randomly and the optical feedback is a requirement for their excitation. The probability of these forms, among the large number of experimental output signals with identifiable waveforms, appearing is only about 3%, with the remainder exhibiting regular SBS characteristics. It is also found that pulses with low period numbers appear more frequently and the probability distribution for their occurrence in terms of the pulse power is roughly L-shaped, like that for rogue waves. The results from a three-wave-coupling model for SBS including feedback phase control agree well qualitatively with the observed phenomena. (paper)

  19. Low Cycle Fatigue of Single Crystal Nickel-based Superalloy DD6 at 1100℃

    Directory of Open Access Journals (Sweden)

    ZHANG Shichao


    Full Text Available The total strain-controlled low cycle fatigue(LCF behaviors of a single crystal superalloy DD6 at 1100℃ for R=-1 and 0.05 were investigated. The results of LCF tests indicated that the cyclic hardening/softening behavior of the alloy not only has the relationship with the microstructure of the material, but also the loading status. The mean stress relaxation occurred under asymmetric straining. The rate of mean stress relaxation increased with the increasing of strain amplitude; when R=-1, the alloy shows tension-compression asymmetry behavior. All the LCF data obtain under various ratios were well correlated by three models for lifetime prediction, the precision rates predicted are fallen into the factor of±2 times scatter band.

  20. Heat transfer and oil flow studies on a single-stage-to-orbit control-configured winged entry vehicle (United States)

    Helms, V. T., III; Bradley, P. F.


    Results are presented for oil flow and phase change paint heat transfer tests conducted on a 0.006 scale model of a proposed single stage to orbit control configured vehicle. The data were taken at angles of attack up to 40 deg at a free stream Mach number of 10 for Reynolds numbers based on model length of 0.5 x 10 to the 6th power, 1.0 x 10 to the 6th power and 2.0 x 10 to the 6th power. The magnitude and distribution of heating are characterized in terms of angle of attack and Reynolds number aided by an analysis of the flow data which are used to suggest the presence of various three dimensional flow structures that produce the observed heating patterns. Of particular interest are streak heating patterns that result in high localized heat transfer rates on the wing windward surface at low to moderate angles of attack. These streaks are caused by the bow-shock/wing-shock interaction and formation of the wing-shock. Embedded vorticity was found to be associated with these interactions.

  1. Orbit analysis

    International Nuclear Information System (INIS)

    Michelotti, L.


    We take an overview of recently developed methods for studying single particle orbits in accelerators and discuss some physics underlying those which involve Lie operators. It will be further argued that object-oriented programming provides the appropriate computing strategy in which to model accelerators and to implement these techniques

  2. Supercharged two-cycle engines employing novel single element reciprocating shuttle inlet valve mechanisms and with a variable compression ratio (United States)

    Wiesen, Bernard (Inventor)


    This invention relates to novel reciprocating shuttle inlet valves, effective with every type of two-cycle engine, from small high-speed single cylinder model engines, to large low-speed multiple cylinder engines, employing spark or compression ignition. Also permitting the elimination of out-of-phase piston arrangements to control scavenging and supercharging of opposed-piston engines. The reciprocating shuttle inlet valve (32) and its operating mechanism (34) is constructed as a single and simple uncomplicated member, in combination with the lost-motion abutments, (46) and (48), formed in a piston skirt, obviating the need for any complex mechanisms or auxiliary drives, unaffected by heat, friction, wear or inertial forces. The reciprocating shuttle inlet valve retains the simplicity and advantages of two-cycle engines, while permitting an increase in volumetric efficiency and performance, thereby increasing the range of usefulness of two-cycle engines into many areas that are now dominated by the four-cycle engine.

  3. Performance comparison of single-stage mixed-refrigerant Joule–Thomson cycle and reverse Brayton cycle for cooling 80 to 120 K temperature-distributed heat loads (United States)

    Wang, H. C.; Chen, G. F.; Gong, M. Q.; Li, X.


    Thermodynamic performance comparison of single-stage mixed-refrigerant Joule–Thomson cycle (MJTR) and pure refrigerant reverse Brayton cycle (RBC) for cooling 80 to 120 K temperature-distributed heat loads was conducted in this paper. Nitrogen under various liquefaction pressures was employed as the heat load. The research was conducted under nonideal conditions by exergy analysis methods. Exergy efficiency and volumetric cooling capacity are two main evaluation parameters. Exergy loss distribution in each process of refrigeration cycle was also investigated. The exergy efficiency and volumetric cooling capacity of MJTR were obviously superior to RBC in 90 to 120 K temperature zone, but still inferior to RBC at 80 K. The performance degradation of MJTR was caused by two main reasons: The high fraction of neon resulted in large entropy generation and exergy loss in throttling process. Larger duty and WLMTD lead to larger exergy losses in recuperator.

  4. Ambulatory urodynamic monitoring of women with overactive bladder syndrome during single voiding cycle. (United States)

    Dokmeci, Fulya; Cetinkaya, S Esra; Seval, M Murat; Dai, Omer


    To present data of standardized ambulatory urodynamic monitoring (AUM) performed in women with overactive bladder syndrome (OAB) and to evaluate the relevance of AUM data with clinical findings of the patients. Records of women with symptoms of OAB were retrospectively reviewed (n=249). Of women fulfilling the Overactive Bladder Awareness Tool (OAB-V8) with a score ≥8 and the 3-day voiding diary (VD) with a frequency >7/day (n=167), those who underwent urodynamic investigation were selected (n=76). The data of this study were retrieved from the records of Ankara University Cebeci Hospital and based on the AUM findings of single voiding cycle of women with OAB. AUM, which is among the institutionally approved primary urodynamic investigation methods, is performed with LUNA ambulatory monitoring recorder (MMS™) in the clinical setting with a standardized technique, in reproducing lower urinary tract symptoms of women since 2011. The relationship of the urodynamic data with the clinical findings were evaluated. AUM traces of women (n=76) with OAB revealed 63.1% DO, 64.4% urgency and 77.7% urinary incontinence of which were 14.4% urgency urinary incontinence (UUI), 25% stress urinary incontinence (SUI) and 38.1% mixed urinary incontinence (MUI). OAB patients with DO reported more urinary incontinence episodes/day, nocturia and mixed urinary incontinence in the voiding diary (p<0.04) and had significantly higher irritative symptom bother reflected by the questionnaires (p<0.04). Women with DO were more likely to be postmenopausal (p=0.02) and were found to have more urgency (p<0.001), urgency episodes (p=0.05) and incontinence (urge and mixed) (p<0.001). However, no association was found between the extent of pelvic organ prolapse and the presence of DO. AUM performed with a standardized technique during single voiding cycle seems to be a reliable method in reproducing symptoms of women with OAB. It provides both clinically relevant findings and objective

  5. Advanced Exo-Brake Development: Parachuting Small Payloads in a Single-Stage from Low Earth Orbit (LEO) (United States)

    National Aeronautics and Space Administration — What is an Exo-Brake/How Does it Work?: The Exo-Brake is a Exo-Atmopsheric drag device that dramatically reduces the ballistic coefficient (above) such that de-orbit...

  6. Optimal design of solid oxide fuel cell, ammonia-water single effect absorption cycle and Rankine steam cycle hybrid system (United States)

    Mehrpooya, Mehdi; Dehghani, Hossein; Ali Moosavian, S. M.


    A combined system containing solid oxide fuel cell-gas turbine power plant, Rankine steam cycle and ammonia-water absorption refrigeration system is introduced and analyzed. In this process, power, heat and cooling are produced. Energy and exergy analyses along with the economic factors are used to distinguish optimum operating point of the system. The developed electrochemical model of the fuel cell is validated with experimental results. Thermodynamic package and main parameters of the absorption refrigeration system are validated. The power output of the system is 500 kW. An optimization problem is defined in order to finding the optimal operating point. Decision variables are current density, temperature of the exhaust gases from the boiler, steam turbine pressure (high and medium), generator temperature and consumed cooling water. Results indicate that electrical efficiency of the combined system is 62.4% (LHV). Produced refrigeration (at -10 °C) and heat recovery are 101 kW and 22.1 kW respectively. Investment cost for the combined system (without absorption cycle) is about 2917 kW-1.

  7. Life cycle cost analysis of single slope hybrid (PV/T) active solar still

    International Nuclear Information System (INIS)

    Kumar, Shiv; Tiwari, G.N.


    This paper presents the life cycle cost analysis of the single slope passive and hybrid photovoltaic (PV/T) active solar stills, based on the annual performance at 0.05 m water depth. Effects of various parameters, namely interest rate, life of the system and the maintenance cost have been taken into account. The comparative cost of distilled water produced from passive solar still (Rs. 0.70/kg) is found to be less than hybrid (PV/T) active solar still (Rs. 1.93/kg) for 30 years life time of the systems. The payback periods of the passive and hybrid (PV/T) active solar still are estimated to be in the range of 1.1-6.2 years and 3.3-23.9 years, respectively, based on selling price of distilled water in the range of Rs. 10/kg to Rs. 2/kg. The energy payback time (EPBT) has been estimated as 2.9 and 4.7 years, respectively. (author)

  8. Dynamic expression of the translational machinery during Bacillus subtilis life cycle at a single cell level.

    Directory of Open Access Journals (Sweden)

    Alex Rosenberg

    Full Text Available The ability of bacteria to responsively regulate the expression of translation components is crucial for rapid adaptation to fluctuating environments. Utilizing Bacillus subtilis (B. subtilis as a model organism, we followed the dynamics of the translational machinery at a single cell resolution during growth and differentiation. By comprehensive monitoring the activity of the major rrn promoters and ribosomal protein production, we revealed diverse dynamics between cells grown in rich and poor medium, with the most prominent dissimilarities exhibited during deep stationary phase. Further, the variability pattern of translational activity varied among the cells, being affected by nutrient availability. We have monitored for the first time translational dynamics during the developmental process of sporulation within the two distinct cellular compartments of forespore and mother-cell. Our study uncovers a transient forespore specific increase in expression of translational components. Finally, the contribution of each rrn promoter throughout the bacterium life cycle was found to be relatively constant, implying that differential expression is not the main purpose for the existence of multiple rrn genes. Instead, we propose that coordination of the rrn operons serves as a strategy to rapidly fine tune translational activities in a synchronized fashion to achieve an optimal translation level for a given condition.

  9. Self-phase modulation of a single-cycle terahertz pulse by nonlinear free-carrier response in a semiconductor

    DEFF Research Database (Denmark)

    Turchinovich, Dmitry; Hvam, Jørn Märcher; Hoffmann, Matthias C.


    We investigate the self-phase modulation (SPM) of a single-cycle terahertz pulse in a semiconductor, using bulk n-GaAs as a model system. The SPM arises from the heating of free electrons in the electric field of the terahertz pulse, leading to an ultrafast reduction of the plasma frequency...

  10. Single versus double intrauterine insemination in stimulated cycles for subfertile couples : a systematic review based on a Cochrane review

    NARCIS (Netherlands)

    Cantineau, AEP; Heineman, MJ; Cohlen, BJ

    BACKGROUND: The objective of this review was to determine, from the best available evidence, the difference in outcome using single versus double intrauterine insemination (IUI) in stimulated cycles for subfertile couples. METHODS: The principles of the Cochrane Menstrual Disorders and Subfertility

  11. Critical firing and misfiring boundary in a spark ignition methanol engine during cold start based on single cycle fuel injection

    International Nuclear Information System (INIS)

    Li, Zhaohui; Gong, Changming; Qu, Xiang; Liu, Fenghua; Sun, Jingzhen; Wang, Kang; Li, Yufeng


    The influence of the mass of methanol injected per cycle, ambient temperature, injection and ignition timing, preheating methods, and supplying additional liquefied petroleum gas (LPG) injection into the intake manifold on the critical firing and misfiring boundary of an electronically injection controlled spark ignition (SI) methanol engine during cold start were investigated experimentally based on a single cycle fuel injection with cycle-by-cycle control strategy. The critical firing and misfiring boundary was restricted by all parameters. For ambient temperatures below 16 °C, methanol engines must use auxiliary start-aids during cold start. Optimal control of the methanol injection and ignition timing can realize ideal next cycle firing combustion after injection. Resistance wire and glow plug preheating can provide critical firing down to ambient temperatures of 5 °C and 0 °C, respectively. Using an additional LPG injection into the intake manifold can provide critical firing down to an ambient temperature of −13 °C during cold start. As the ambient temperature decreases, the optimal angle difference between methanol injection timing and LPG injection timing for critical firing of a methanol engine increases rapidly during cold start. - Highlights: • A single cycle fuel injection and cycle-by-cycle control strategy are used to study. • In-cylinder pressure and instantaneous speed were used to determine firing boundary. • For the ambient temperatures below 16 °C, an auxiliary start-aids must be used. • A preheating and additional LPG were used to expand critical firing boundary. • Additional LPG can result in critical firing down to ambient temperature of −13 °C

  12. Glacial-Interglacial, Orbital and Millennial-Scale Climate Variability for the Last Glacial Cycle at Shackleton Site U1385 based on Dinoflagellate Cysts (United States)

    Datema, M.


    The Shackleton Site (IODP Expedition 339 Site U1385), located off the West-Portuguese Margin, preserves a continuous high-fidelity record of millennial-scale climate variability for the last several glacial cycles (~1.4 Myr) that can be correlated precisely to patterns observed in polar ice cores. In addition, rapid delivery of terrestrial material to the deep-sea environment allows the correlation of these marine records to European terrestrial climate records. This unique marine-ice-terrestrial linkage makes the Shackleton Site the ideal reference section for studying Quaternary abrupt climate change. The main objective of studying Site U1385 is to establish a marine reference section of Pleistocene climate change. We generated (sub)millennial-scale (~600 year interval) dinoflagellate cyst (dinocyst) assemblage records from Shackleton Site U1385 (IODP Expedition 339) to reconstruct sea surface temperature (SST) and productivity/upwelling over the last 152 kyrs. In addition, our approach allows for detailed land-sea correlations, because we also counted assemblages of pollen and spores from higher plants. Dinocyst SST and upwelling proxies, as well as warm/cold pollen proxies from Site U1385 show glacial-interglacial, orbital and stadial-interstadial climate variability and correlate very well to Uk'37, planktic foraminifer δ18O and Ca/Ti proxies of previously drilled Shackleton Sites and Greenland Ice Core δ18O. The palynological proxies capture (almost) all Dansgaard-Oeschger events of the last glacial cycle, also before ~70 ka, where millennial-scale variability is overprinted by precession. We compare the performance and results of the palynology of Site U1385 to proxies of previously drilled Shackleton Sites and conclude that palynology strengthens the potential of this site to form a multi-proxy reference section for millennial scale climate variability across the Pleistocene-Holocene. Finally, we will present a long-term paleoceanographic perspective down

  13. Computational Study on M1/POM Single-Atom Catalysts (M = Cu, Zn, Ag, and Au; POM = [PW12O40]3-): Metal-Support Interactions and Catalytic Cycle for Alkene Epoxidation. (United States)

    Liu, Chun-Guang; Jiang, Meng-Xu; Su, Zhong-Min


    Geometrical structures, metal-support interactions, and infrared (IR) spectroscopy of a series of M 1 /POM (M = Cu, Zn, Ag, and Au; POM = [PW 12 O 40 ] 3- ) single-atom catalysts (SACs), and catalytic cycle for alkene epoxidation catalyzed by M 1 /POM SACs were studied using density functional theory (DFT) calculations. The calculations demonstrate that the most probable anchoring sties for the isolated single atoms studied here in the M 1 /POM SACs are the fourfold hollow sites on the surface of POM support. The bonding interaction between single metal atom and surface of POM support comes from the molecular orbitals with a mixture of d atomic orbital of metal and 2p group orbital of surface oxygen atoms of POM cage. The calculated adsorption energy of isolated metal atoms in these M 1 /POM SACs indicates that the early transition metals (Cu and Zn) have high thermal stability. The DFT-derived IR spectra show that the four characteristic peaks of free Keggin-type POM structure split into six because of introduction of isolated metal atom. Compared with other metal atoms, the Zn 1 /POM SAC has the high reactivity for activity of dioxygen molecule, because the dioxygen moiety in Zn 1 /POM SAC displays O 2 - · radical feature with [POM 4- ·Zn 2+ O 2 - ·] 3- configuration. Finally, a catalytic cycle for ethylene epoxidation by O 2 catalyzed by Zn 1 /POM SAC was proposed based on our DFT calculations. Supported noble-metal SACs are among the most important catalysts currently. However, noble metals are expensive and of limited supply. Development of non-noble-metal SACs is of essential importance. Therefore, the reported Zn 1 /POM SAC would be very useful to guide the search for SACs into non-noble metals.

  14. Administration of single-dose GnRH agonist in the luteal phase in ICSI cycles: a meta-analysis

    Directory of Open Access Journals (Sweden)

    Oliveira João


    Full Text Available Abstract Background The effects of gonadotrophin-releasing hormone agonist (GnRH-a administered in the luteal phase remains controversial. This meta-analysis aimed to evaluate the effect of the administration of a single-dose of GnRH-a in the luteal phase on ICSI clinical outcomes. Methods The research strategy included the online search of databases. Only randomized studies were included. The outcomes analyzed were implantation rate, clinical pregnancy rate (CPR per transfer and ongoing pregnancy rate. The fixed effects model was used for odds ratio. In all trials, a single dose of GnRH-a was administered at day 5/6 after ICSI procedures. Results All cycles presented statistically significantly higher rates of implantation (P Conclusions These findings demonstrate that the luteal-phase single-dose GnRH-a administration can increase implantation rate in all cycles and CPR per transfer and ongoing pregnancy rate in cycles with GnRH antagonist ovarian stimulation protocol. Nevertheless, by considering the heterogeneity between the trials, it seems premature to recommend the use of GnRH-a in the luteal phase. Additional randomized controlled trials are necessary before evidence-based recommendations can be provided.

  15. Universal route to optimal few- to single-cycle pulse generation in hollow-core fiber compressors. (United States)

    Conejero Jarque, E; San Roman, J; Silva, F; Romero, R; Holgado, W; Gonzalez-Galicia, M A; Alonso, B; Sola, I J; Crespo, H


    Gas-filled hollow-core fiber (HCF) pulse post-compressors generating few- to single-cycle pulses are a key enabling tool for attosecond science and ultrafast spectroscopy. Achieving optimum performance in this regime can be extremely challenging due to the ultra-broad bandwidth of the pulses and the need of an adequate temporal diagnostic. These difficulties have hindered the full exploitation of HCF post-compressors, namely the generation of stable and high-quality near-Fourier-transform-limited pulses. Here we show that, independently of conditions such as the type of gas or the laser system used, there is a universal route to obtain the shortest stable output pulse down to the single-cycle regime. Numerical simulations and experimental measurements performed with the dispersion-scan technique reveal that, in quite general conditions, post-compressed pulses exhibit a residual third-order dispersion intrinsic to optimum nonlinear propagation within the fiber, in agreement with measurements independently performed in several laboratories around the world. The understanding of this effect and its adequate correction, e.g. using simple transparent optical media, enables achieving high-quality post-compressed pulses with only minor changes in existing setups. These optimized sources have impact in many fields of science and technology and should enable new and exciting applications in the few- to single-cycle pulse regime.

  16. A new six stroke single cylinder diesel engine referring Rankine cycle

    International Nuclear Information System (INIS)

    Chen, Hao; Guo, Qi; Yang, Lu; Liu, Shenghua; Xie, Xuliang; Chen, Zhaoyang; Liu, Zengqiang


    Six stroke engine presented by Conklin and Szybist is an effective way to recover energy of exhaust gas by adding a partial exhaust stroke and steam expansion stroke. Characteristics of the engine are analyzed and its disadvantages are pointed out. A new six stroke diesel engine is presented here. It refers rankine cycle inside cylinder. Total exhaust gas is recompressed and at a relatively low back pressure in the fourth stroke water is injected to which maintains liquid phase until the piston moves to the TDC. At c′ 720 °CA (crank angle) the water becomes saturated. An ideal thermodynamics model of exhaust gas compression, water injection and expansion is constructed to investigate this modification. Properties at characteristic points are calculated to determine the increased indicated work. Results show that the work increases with the advance of water injection timing and the quality of water. The cycle is more efficient and the new engine has potential for saving energy. Moreover, it is forecasted that HC and PM emissions may reform with steam in reality and H 2 is produced which will react with NO X . - Highlights: • A new six stroke diesel engine is introduced and a new ideal cycle is constructed. • Increased indicated work of the cycle proves that the cycle is more efficient. • In reality steam may reform with HC and PM and produced H 2 may react with NO X emission. • The engine has the potential for energy saving and emission reducing

  17. The Single Cell Proteome Project - Cell-Cycle Dependent Protein Expression in Breast Cancer Cell Lines

    National Research Council Canada - National Science Library

    Dovichi, Norman J


    .... Capillary sieving electrophoresis and capillary micellar electrophoresis were used to characterize proteins in single cells in one-dimensional separations, while the two techniques were combined...

  18. Experimental Comparison Of Working Fluids For Organic Rankine Cycle With Single-Screw Expander


    Gusev, Sergei; Ziviani, Davide; Bell, Ian; De Paepe, Michel; van den Broek, Martijn


    This paper describes the behavior of an Organic Rankine Cycle (ORC) fed by a heat source with adaptable temperature and mass flow. For a suitable choice of working fluid, the setting of its evaporation pressure is crucial for the performance of an ORC installation. The higher the evaporation pressure, the higher the cycle efficiency on the one hand, but the lower the energy recovered from the heat source due to a higher outlet temperature on the other hand. An optimum has to be found to achie...

  19. Optimum Envelope of a Single-Family House Based on Life Cycle Analysis


    Marie-Claude Hamelin; Radu Zmeureanu


    This paper describes the methodology used for the life cycle cost (LCC) and life cycle energy (LCE) analyses of the case study house in Quebec, Canada. The TRNSYS energy analysis program is coupled with GenOpt, a general purpose optimization program, for the purpose of this study. The particle swarm optimization (PSO) algorithm is used for the search for the optimum solution. Results show that the optimum levels of insulation should be higher than the reference values, even for the case of LC...

  20. Orbit analysis

    International Nuclear Information System (INIS)

    Michelotti, L.


    The past fifteen years have witnessed a remarkable development of methods for analyzing single particle orbit dynamics in accelerators. Unlike their more classic counterparts, which act upon differential equations, these methods proceed by manipulating Poincare maps directly. This attribute makes them well matched for studying accelerators whose physics is most naturally modelled in terms of maps, an observation that has been championed most vigorously by Forest. In the following sections the author sketchs a little background, explains some of the physics underlying these techniques, and discusses the best computing strategy for implementing them in conjunction with modeling accelerators

  1. Orbit analysis

    Energy Technology Data Exchange (ETDEWEB)

    Michelotti, L.


    The past fifteen years have witnessed a remarkable development of methods for analyzing single particle orbit dynamics in accelerators. Unlike their more classic counterparts, which act upon differential equations, these methods proceed by manipulating Poincare maps directly. This attribute makes them well matched for studying accelerators whose physics is most naturally modelled in terms of maps, an observation that has been championed most vigorously by Forest. In the following sections the author sketchs a little background, explains some of the physics underlying these techniques, and discusses the best computing strategy for implementing them in conjunction with modeling accelerators.

  2. Single and combined effects of beetroot juice and caffeine supplementation on cycling time trial performance. (United States)

    Lane, Stephen C; Hawley, John A; Desbrow, Ben; Jones, Andrew M; Blackwell, James R; Ross, Megan L; Zemski, Adam J; Burke, Louise M


    Both caffeine and beetroot juice have ergogenic effects on endurance cycling performance. We investigated whether there is an additive effect of these supplements on the performance of a cycling time trial (TT) simulating the 2012 London Olympic Games course. Twelve male and 12 female competitive cyclists each completed 4 experimental trials in a double-blind Latin square design. Trials were undertaken with a caffeinated gum (CAFF) (3 mg·kg(-1) body mass (BM), 40 min prior to the TT), concentrated beetroot juice supplementation (BJ) (8.4 mmol of nitrate (NO3(-)), 2 h prior to the TT), caffeine plus beetroot juice (CAFF+BJ), or a control (CONT). Subjects completed the TT (females: 29.35 km; males: 43.83 km) on a laboratory cycle ergometer under conditions of best practice nutrition: following a carbohydrate-rich pre-event meal, with the ingestion of a carbohydrate-electrolyte drink and regular oral carbohydrate contact during the TT. Compared with CONT, power output was significantly enhanced after CAFF+BJ and CAFF (3.0% and 3.9%, respectively, p caffeine (-0.9%, p = 0.4 compared with CAFF). We conclude that caffeine (3 mg·kg(-1) BM) administered in the form of a caffeinated gum increased cycling TT performance lasting ∼50-60 min by ∼3%-4% in both males and females. Beetroot juice supplementation was not ergogenic under the conditions of this study.

  3. Precise orbit and attitude determination using redundant low-cost single-frequency GNSS receivers on a CubeSat (United States)

    Willi, Daniel; Fisler, Michael; Hollenstein, Christine; Männel, Benjamin; Meindl, Michael; Xu, Hui; Rothacher, Markus


    CubETH is a technology demonstration mission aimed at using low-cost commercial-off-the-shelf GNSS receivers for space applications. Precise orbit and attitude determination, on-board as well as in post-processing, are the main mission goals. The one unit cube-satellite is equipped with five GNSS antennas, each of them connected to two u-blox multi-GNSS receivers. The position estimation on the satellite is based on the receiver navigation solution. We show that (1) the proper correction of the ionospheric path delay and (2) the position propagation in the Kalman filter are of uppermost importance. Based on available data from the GRACE and GOCE missions, we show how an adapted Klobuchar model leads to a better estimation of the path delay in low Earth orbits. Based on recent signal-simulator tests, we illustrate how the linear propagation in the receiver Kalman filter leads to systematic errors and exhibit a method for improvement.

  4. Lineage correlations of single cell division time as a probe of cell-cycle dynamics. (United States)

    Sandler, Oded; Mizrahi, Sivan Pearl; Weiss, Noga; Agam, Oded; Simon, Itamar; Balaban, Nathalie Q


    Stochastic processes in cells are associated with fluctuations in mRNA, protein production and degradation, noisy partition of cellular components at division, and other cell processes. Variability within a clonal population of cells originates from such stochastic processes, which may be amplified or reduced by deterministic factors. Cell-to-cell variability, such as that seen in the heterogeneous response of bacteria to antibiotics, or of cancer cells to treatment, is understood as the inevitable consequence of stochasticity. Variability in cell-cycle duration was observed long ago; however, its sources are still unknown. A central question is whether the variance of the observed distribution originates from stochastic processes, or whether it arises mostly from a deterministic process that only appears to be random. A surprising feature of cell-cycle-duration inheritance is that it seems to be lost within one generation but to be still present in the next generation, generating poor correlation between mother and daughter cells but high correlation between cousin cells. This observation suggests the existence of underlying deterministic factors that determine the main part of cell-to-cell variability. We developed an experimental system that precisely measures the cell-cycle duration of thousands of mammalian cells along several generations and a mathematical framework that allows discrimination between stochastic and deterministic processes in lineages of cells. We show that the inter- and intra-generation correlations reveal complex inheritance of the cell-cycle duration. Finally, we build a deterministic nonlinear toy model for cell-cycle inheritance that reproduces the main features of our data. Our approach constitutes a general method to identify deterministic variability in lineages of cells or organisms, which may help to predict and, eventually, reduce cell-to-cell heterogeneity in various systems, such as cancer cells under treatment.

  5. Weighting and Aggregation in Life Cycle Assessment: Do Present Aggregated Single Scores Provide Correct Decision Support?

    DEFF Research Database (Denmark)

    Kalbar, Pradip; Birkved, Morten; Nygaard, Simon Elsborg


    approach was adopted to facilitate identification of three main problems related to the single-score calculation approach. The prevailing ReCiPe single-score calculation method does not account for either the effect of so-called dominating alternatives (i.e., alternatives having high values across all...... endpoints) or the interdependency of the indicators being aggregated. It was also found that the simple linear weighted sum method, presently used for obtaining single scores, is not capable of accounting for the effect of weighting schemes and thus cannot realistically represent stakeholders' perspectives...

  6. Orbital exenteration--a retrospective study over an 11 year period analyzing all cases from a single unit. (United States)

    Taylor, A; Roberts, F; Kemp, E G


    A retrospective analysis of all cases of orbital exenteration performed at the National Scottish Ocular Oncology Center over an 11 year period. We sought all exenteration cases (1993-2003) from ocular oncology and oculoplastic databases. Fifteen exenterations were performed. One case record was irretrievable. Clinicopathological features and outcome of 14 patients were analyzed. All operations were performed by the same consultant. The male to female ratio was 1:1 and the average age at surgery was 66 years. There was a left sided predominance of pathology demonstrated (right to left orbit ratio was 1:1.3. The average follow up period postsurgery was 35 months. The most common underlying diagnosis was malignant melanoma (9/14). Ocular/orbital discomfort was the most frequent presenting symptom (7/14); a mass lesion (10/14) was the most common presenting sign. The average duration of symptoms/signs prior to tertiary institution referral was 10.9 months (range: 0.5-60 months). Exenteration was performed on average 39.7 months (range: 0.13-204) after initial tertiary center presentation. This included patients managed from the outset who failed treatment(s) and then required exenteration. The eyelids were sacrificed in ten cases (10/14). Sockets were lined with eyelid skin (4/10), split skin (thigh) (3/10) or healed secondarily (7/10). Thirteen cases (13/14) had clear histological margins. The average post operative stay was 8.3 days. The most common complication was socket fistula formation (7/14). Ethmoid sinuses were always involved. The average time to fistula development was 4.9 months (sockets lined by skin = 2.2 months compared with sockets left to heal secondarily = 6.9 months). The majority of patients wore occlusive shields long term. The most common pathology necessitating exenteration was malignant melanoma. Most patients presented with a mass lesion. Histological tumor free margins were obtained in thirteen of fourteen cases. The most common complication

  7. Retinoblastoma presenting with orbital cellulitis. (United States)

    Walinjkar, Jaydeep; Krishnakumar, S; Gopal, Lingam; Ramesh, Anita; Khetan, Vikas


    To study the effectiveness of pre-enucleation steroids in reducing inflammation in patients with retinoblastoma presenting as orbital cellulitis. Medical records of consecutive retinoblastoma patients presenting at a single tertiary eye care center during a period of 3 years were retrospectively reviewed. For those who presented with orbital cellulitis, clinical, radiological, and histopathological variables were assessed. The effect of pre-enucleation steroids was noted in this group of patients. Of 260 retinoblastoma cases reviewed, 14 had retinoblastoma-associated cellulitis (5.39%). Of these 14 patients, 4 received neoadjuvant chemotherapy and were excluded from the series. Of the remaining 10 cases (mean age at presentation, 14.2 months; mean follow-up, 16.4 months), 9 presented with orbital cellulitis and were included in the study. Radiological imaging depicted intraocular tumors occupying 80% to 100% of the globe in each case. All patients underwent enucleation. Five children received pre-enucleation systemic steroids (mean, 5.4 days), which resulted in a prompt decrease in inflammation. Postenucleation chemotherapy was administered in 4 (6 cycles) and external beam radiation therapy in 1 patient with high-risk histopathological characteristics. Advanced necrotic retinoblastoma with anterior segment involvement may present as orbital cellulitis. Pre-enucleation systemic steroids can aid in the surgical management of these tumors. Copyright © 2013 American Association for Pediatric Ophthalmology and Strabismus. Published by Mosby, Inc. All rights reserved.

  8. Using single cell cultivation system for on-chip monitoring of the interdivision timer in Chlamydomonas reinhardtii cell cycle

    Directory of Open Access Journals (Sweden)

    Soloviev Mikhail


    Full Text Available Abstract Regulation of cell cycle progression in changing environments is vital for cell survival and maintenance, and different regulation mechanisms based on cell size and cell cycle time have been proposed. To determine the mechanism of cell cycle regulation in the unicellular green algae Chlamydomonas reinhardtii, we developed an on-chip single-cell cultivation system that allows for the strict control of the extracellular environment. We divided the Chlamydomonas cell cycle into interdivision and division phases on the basis of changes in cell size and found that, regardless of the amount of photosynthetically active radiation (PAR and the extent of illumination, the length of the interdivision phase was inversely proportional to the rate of increase of cell volume. Their product remains constant indicating the existence of an 'interdivision timer'. The length of the division phase, in contrast, remained nearly constant. Cells cultivated under light-dark-light conditions did not divide unless they had grown to twice their initial volume during the first light period. This indicates the existence of a 'commitment sizer'. The ratio of the cell volume at the beginning of the division phase to the initial cell volume determined the number of daughter cells, indicating the existence of a 'mitotic sizer'.

  9. Optimum Envelope of a Single-Family House Based on Life Cycle Analysis

    Directory of Open Access Journals (Sweden)

    Marie-Claude Hamelin


    Full Text Available This paper describes the methodology used for the life cycle cost (LCC and life cycle energy (LCE analyses of the case study house in Quebec, Canada. The TRNSYS energy analysis program is coupled with GenOpt, a general purpose optimization program, for the purpose of this study. The particle swarm optimization (PSO algorithm is used for the search for the optimum solution. Results show that the optimum levels of insulation should be higher than the reference values, even for the case of LCC analysis. The results are for the most part still valid if electricity costs are assumed to increase below the inflation rate for the duration of the study period.

  10. Single SOA based 16 DWDM channels all-optical NRZ-to-RZ format conversions with different duty cycles. (United States)

    Yu, Yu; Zhang, Xinliang; Rosas-Fernández, J B; Huang, Dexiu; Penty, R V; White, I H


    We demonstrate simultaneous NRZ-to-RZ conversion for 16 DWDM channels, using a single SOA and a subsequent delay interferometer (DI) acting as a comb-like filter to control the obtained pulse-width for all of the channels. The SOA is operated in deep saturation, resulting in weak cross gain modulation and cross phase modulation induced crosstalk between different NRZ channels. By adjusting the detuning between the peaks in the DI spectrum and each corresponding carrier, good quality RZ signals with different duty cycles can be achieved. Bit-error-rate measurements show negative power penalties for the obtained RZ signals with different duty cycles. Significant timing jitter reductions for all channels show the good regenerative performance of the proposed converter.

  11. Time-lapse electrical impedance spectroscopy for monitoring the cell cycle of single immobilized S. pombe cells (United States)

    Zhu, Zhen; Frey, Olivier; Haandbaek, Niels; Franke, Felix; Rudolf, Fabian; Hierlemann, Andreas


    As a complement and alternative to optical methods, wide-band electrical impedance spectroscopy (EIS) enables multi-parameter, label-free and real-time detection of cellular and subcellular features. We report on a microfluidics-based system designed to reliably capture single rod-shaped Schizosaccharomyces pombe cells by applying suction through orifices in a channel wall. The system enables subsequent culturing of immobilized cells in an upright position, while dynamic changes in cell-cycle state and morphology were continuously monitored through EIS over a broad frequency range. Besides measuring cell growth, clear impedance signals for nuclear division have been obtained. The EIS system has been characterized with respect to sensitivity and detection limits. The spatial resolution in measuring cell length was 0.25 μm, which corresponds to approximately a 5-min interval of cell growth under standard conditions. The comprehensive impedance data sets were also used to determine the occurrence of nuclear division and cytokinesis. The obtained results have been validated through concurrent confocal imaging and plausibilized through comparison with finite-element modeling data. The possibility to monitor cellular and intracellular features of single S. pombe cells during the cell cycle at high spatiotemporal resolution renders the presented microfluidics-based EIS system a suitable tool for dynamic single-cell investigations.

  12. High-energy electron emission from metallic nano-tips driven by intense single-cycle terahertz pulses (United States)

    Li, Sha; Jones, R. R.


    Electrons ejected from atoms and subsequently driven to high energies in strong laser fields enable techniques from attosecond pulse generation to imaging with rescattered electrons. Analogous processes govern strong-field electron emission from nanostructures, where long wavelength radiation and large local field enhancements hold the promise for producing electrons with substantially higher energies, allowing for higher resolution time-resolved imaging. Here we report on the use of single-cycle terahertz pulses to drive electron emission from unbiased nano-tips. Energies exceeding 5 keV are observed, substantially greater than previously attained at higher drive frequencies. Despite large differences in the magnitude of the respective local fields, we find that the maximum electron energies are only weakly dependent on the tip radius, for 10 nmsingle-cycle nature of the field, the high-energy electron emission is predicted to be confined to a single burst, potentially enabling a variety of applications. PMID:27830701

  13. Transient impairments in single muscle fibre contractile function after prolonged cycling in elite endurance athletes

    DEFF Research Database (Denmark)

    Hvid, L G; Gejl, Kasper Degn; Bech, R D


    Prolonged muscle activity impairs whole-muscle performance and function. However, little is known about the effects of prolonged muscle activity on the contractile function of human single muscle fibres. The purpose of this study was to investigate the effects of prolonged exercise and subsequent...

  14. Spatially multiplexed orbital-angular-momentum-encoded single photon and classical channels in a free-space optical communication link. (United States)

    Ren, Yongxiong; Liu, Cong; Pang, Kai; Zhao, Jiapeng; Cao, Yinwen; Xie, Guodong; Li, Long; Liao, Peicheng; Zhao, Zhe; Tur, Moshe; Boyd, Robert W; Willner, Alan E


    We experimentally demonstrate spatial multiplexing of an orbital angular momentum (OAM)-encoded quantum channel and a classical Gaussian beam with a different wavelength and orthogonal polarization. Data rates as large as 100 MHz are achieved by encoding on two different OAM states by employing a combination of independently modulated laser diodes and helical phase holograms. The influence of OAM mode spacing, encoding bandwidth, and interference from the co-propagating Gaussian beam on registered photon count rates and quantum bit error rates is investigated. Our results show that the deleterious effects of intermodal crosstalk effects on system performance become less important for OAM mode spacing Δ≥2 (corresponding to a crosstalk value of less than -18.5  dB). The use of OAM domain can additionally offer at least 10.4 dB isolation besides that provided by wavelength and polarization, leading to a further suppression of interference from the classical channel.

  15. A new near-linear scaling, efficient and accurate, open-shell domain-based local pair natural orbital coupled cluster singles and doubles theory (United States)

    Saitow, Masaaki; Becker, Ute; Riplinger, Christoph; Valeev, Edward F.; Neese, Frank


    The Coupled-Cluster expansion, truncated after single and double excitations (CCSD), provides accurate and reliable molecular electronic wave functions and energies for many molecular systems around their equilibrium geometries. However, the high computational cost, which is well-known to scale as O(N6) with system size N, has limited its practical application to small systems consisting of not more than approximately 20-30 atoms. To overcome these limitations, low-order scaling approximations to CCSD have been intensively investigated over the past few years. In our previous work, we have shown that by combining the pair natural orbital (PNO) approach and the concept of orbital domains it is possible to achieve fully linear scaling CC implementations (DLPNO-CCSD and DLPNO-CCSD(T)) that recover around 99.9% of the total correlation energy [C. Riplinger et al., J. Chem. Phys. 144, 024109 (2016)]. The production level implementations of the DLPNO-CCSD and DLPNO-CCSD(T) methods were shown to be applicable to realistic systems composed of a few hundred atoms in a routine, black-box fashion on relatively modest hardware. In 2011, a reduced-scaling CCSD approach for high-spin open-shell unrestricted Hartree-Fock reference wave functions was proposed (UHF-LPNO-CCSD) [A. Hansen et al., J. Chem. Phys. 135, 214102 (2011)]. After a few years of experience with this method, a few shortcomings of UHF-LPNO-CCSD were noticed that required a redesign of the method, which is the subject of this paper. To this end, we employ the high-spin open-shell variant of the N-electron valence perturbation theory formalism to define the initial guess wave function, and consequently also the open-shell PNOs. The new PNO ansatz properly converges to the closed-shell limit since all truncations and approximations have been made in strict analogy to the closed-shell case. Furthermore, given the fact that the formalism uses a single set of orbitals, only a single PNO integral transformation is

  16. Factors affecting 223Ra therapy: clinical experience after 532 cycles from a single institution

    International Nuclear Information System (INIS)

    The aim of this study was to identify baseline features that predict outcome in 223 Ra therapy. We retrospectively reviewed 110 patients with metastatic castration-resistant prostate cancer treated with 223 Ra. End points were overall survival (OS), progression-free survival (PFS), bone event-free survival (BeFS), and bone marrow failure (BMF). The following parameters were evaluated prior to the first 223 Ra cycle: serum levels of hemoglobin (Hb), prostate-specific antigen (PSA), alkaline phosphatase (ALP), Eastern Cooperative Oncology Group (ECOG) status, pain score, use of chemotherapy, and external beam radiation therapy (EBRT). During/after 223 Ra we evaluated: the total number of radium cycles (Ra Tot ), the PSA doubling time (PSA DT ), and the use of chemotherapy, EBRT, abiraterone, and enzalutamide. A significant reduction of ALP (p < 0.001) and pain score (p = 0.041) occurred throughout the 223 Ra cycles. The risk of progression was associated with declining ECOG status [hazard ratio (HR) = 3.79; p < 0.001] and decrease in PSA DT (HR = 8.22; p < 0.001). Ra Tot , ALP, initial ECOG status, initial pain score, and use of abiraterone were associated with OS (p ≤ 0.008), PFS (p ≤ 0.003), and BeFS (p ≤ 0.020). Ra Tot , ALP, initial ECOG status, and initial pain score were significantly associated with BMF (p ≤ 0.001) as well as Hb (p < 0.001) and EBRT (p = 0.009). On multivariable analysis, only Ra Tot and abiraterone remained significantly associated with OS (p < 0.001; p = 0.033, respectively), PFS (p < 0.001; p = 0.041, respectively), and BeFS (p < 0.001; p = 0.019, respectively). Additionally, Ra Tot (p = 0.027) and EBRT (p = 0.013) remained significantly associated with BMF. Concomitant use of abiraterone and 223 Ra seems to have a beneficial effect, while the EBRT may increase the risk of BMF. (orig.)

  17. Factors affecting {sup 223}Ra therapy: clinical experience after 532 cycles from a single institution

    Energy Technology Data Exchange (ETDEWEB)

    Etchebehere, Elba C. [The University of Texas MD Anderson Cancer Center, Department of Nuclear Medicine, Houston, TX (United States); Campinas State University (Unicamp), Department of Nuclear Medicine, Campinas (Brazil); Milton, Denai R. [The University of Texas MD Anderson Cancer Center, Department of Biostatistics, Houston, TX (United States); Araujo, John C. [The University of Texas MD Anderson Cancer Center, Department of Genitourinary Medical Oncology, Houston, TX (United States); Swanston, Nancy M.; Macapinlac, Homer A.; Rohren, Eric M. [The University of Texas MD Anderson Cancer Center, Department of Nuclear Medicine, Houston, TX (United States)


    The aim of this study was to identify baseline features that predict outcome in {sup 223}Ra therapy. We retrospectively reviewed 110 patients with metastatic castration-resistant prostate cancer treated with {sup 223}Ra. End points were overall survival (OS), progression-free survival (PFS), bone event-free survival (BeFS), and bone marrow failure (BMF). The following parameters were evaluated prior to the first {sup 223}Ra cycle: serum levels of hemoglobin (Hb), prostate-specific antigen (PSA), alkaline phosphatase (ALP), Eastern Cooperative Oncology Group (ECOG) status, pain score, use of chemotherapy, and external beam radiation therapy (EBRT). During/after {sup 223}Ra we evaluated: the total number of radium cycles (Ra{sub Tot}), the PSA doubling time (PSA{sub DT}), and the use of chemotherapy, EBRT, abiraterone, and enzalutamide. A significant reduction of ALP (p < 0.001) and pain score (p = 0.041) occurred throughout the {sup 223} Ra cycles. The risk of progression was associated with declining ECOG status [hazard ratio (HR) = 3.79; p < 0.001] and decrease in PSA{sub DT} (HR = 8.22; p < 0.001). Ra{sub Tot}, ALP, initial ECOG status, initial pain score, and use of abiraterone were associated with OS (p ≤ 0.008), PFS (p ≤ 0.003), and BeFS (p ≤ 0.020). Ra{sub Tot}, ALP, initial ECOG status, and initial pain score were significantly associated with BMF (p ≤ 0.001) as well as Hb (p < 0.001) and EBRT (p = 0.009). On multivariable analysis, only Ra{sub Tot} and abiraterone remained significantly associated with OS (p < 0.001; p = 0.033, respectively), PFS (p < 0.001; p = 0.041, respectively), and BeFS (p < 0.001; p = 0.019, respectively). Additionally, Ra{sub Tot} (p = 0.027) and EBRT (p = 0.013) remained significantly associated with BMF. Concomitant use of abiraterone and {sup 223}Ra seems to have a beneficial effect, while the EBRT may increase the risk of BMF. (orig.)

  18. Interaction of high cycle fatigue with high temperature creep in superalloy single crystals

    Czech Academy of Sciences Publication Activity Database

    Lukáš, Petr; Kunz, Ludvík; Svoboda, Milan


    Roč. 93, č. 7 (2002), s. 661-665 ISSN 0044-3093 R&D Projects: GA AV ČR IAA2041002; GA AV ČR KSK1010104 Institutional research plan: CEZ:AV0Z2041904 Keywords : Single crystals * Creep/fatigue interaction * Persistent slip bands Subject RIV: JL - Materials Fatigue, Friction Mechanics Impact factor: 0.636, year: 2002

  19. Consequences of Spin-Orbit Coupling at the Single Hole Level: Spin-Flip Tunneling and the Anisotropic g Factor. (United States)

    Bogan, A; Studenikin, S A; Korkusinski, M; Aers, G C; Gaudreau, L; Zawadzki, P; Sachrajda, A S; Tracy, L A; Reno, J L; Hargett, T W


    Hole transport experiments were performed on a gated double quantum dot device defined in a p-GaAs/AlGaAs heterostructure with a single hole occupancy in each dot. The charging diagram of the device was mapped out using charge detection confirming that the single hole limit is reached. In that limit, a detailed study of the two-hole spin system was performed using high bias magnetotransport spectroscopy. In contrast to electron systems, the hole spin was found not to be conserved during interdot resonant tunneling. This allows one to fully map out the two-hole energy spectrum as a function of the magnitude and the direction of the external magnetic field. The heavy-hole g factor was extracted and shown to be strongly anisotropic, with a value of 1.45 for a perpendicular field and close to zero for an in-plane field as required for hybridizing schemes between spin and photonic quantum platforms.

  20. Coefficient of Performance Optimization of Single-Effect Lithium-Bromide Absorption Cycle Heat Pumps

    DEFF Research Database (Denmark)

    Vinther, Kasper; Just Nielsen, Rene; Nielsen, Kirsten Mølgaard


    In this paper, we investigate the coefficient of performance (COP) of a LiBr absorption cycle heat pump under different operating conditions. The investigation is carried out using a dynamical model fitted against data recorded from an actual heat pump used for district heating in S......⊘nderborg, Denmark. Since the model is too complex to study analytically, we vary different input variables within the permissible operating range of the heat pump and evaluate COP at the resulting steady-state operating points. It is found that the best set-point for each individual input is located at an extreme...... value of the investigated permissible range, and that the COP optimization is likely to be a convex problem. Further, we exploit this observation to propose a simple offline set-point optimization algorithm, which can be used as an automated assistance for the plant operator to optimize steady...

  1. Influence of Cooling Holes Distribution on High Cycle Fatigue Fracture Behavior of DD6 Single Crystal Superalloy

    Directory of Open Access Journals (Sweden)

    HU Chun-yan


    Full Text Available The modeling air-cooled turbine blades specimens of DD6 single crystal superalloy with different distributions of cooling film holes were used to study the high cycle fatigue properties at room temperature. The SEM fracture observation was carried out. The results indicate that the cooling holes have significant effects on the high fatigue life of DD6 single crystal superalloy. The average life of non-hole specimens is four times of that of the three-row holes specimens under the same testing conditions. However, the distribution of cooling film holes has relatively less influence on fatigue life. The fracture of the specimens with non-hole is linear source by SEM analysis, but the cracks are found around the cooling film holes and the fracture of the specimens with single row to three rows is a typical multi-source rupture, and cracks all initiate from near film holes. According to fracture and crystallography theoretical conjecture, the cracks propagate along the {001} slip plane for non-hole, single-row holes and the middle location of the multi-row holes specimens. However, the cracks around the holes grow along the {111} slip plane for upper and lower holes of the specimens with multi-row holes. In addition, the distribution of stress field along cooling holes of four different specimens was analysed by FEM method. The results show that the fracture location and morphology of specimens are consistent well with numerical simulation analysis.

  2. Sulfur isotopic constraints from a single enzyme on the cellular to global sulfur cycles (United States)

    Sim, M. S.; Adkins, J. F.; Sessions, A. L.; Orphan, V. J.; McGlynn, S.


    Since first reported more than a half century ago, sulfur isotope fractionation between sulfate and sulfide has been used as a diagnostic indicator of microbial sulfate reduction, giving added dimensions to the microbial ecological and geochemical studies of the sulfur cycle. A wide range of fractionation has attracted particular attention because it may serve as a potential indicator of environmental or physiological variables such as substrate concentrations or specific respiration rates. In theory, the magnitude of isotope fractionation depends upon the sulfur isotope effect imparted by the involved enzymes and the relative rate of each enzymatic reaction. The former defines the possible range of fractionation quantitatively, while the latter responds to environmental stimuli, providing an underlying rationale for the varying fractionations. The experimental efforts so far have concentrated largely on the latter, the factors affecting the size of fractionation. Recently, however, the direct assessment of intracellular processes emerges as a promising means for the quantitative analysis of microbial sulfur isotope fractionation as a function of environmental or physiological variables. Here, we experimentally determined for the first time the sulfur isotope fractionation during APS reduction, the first reductive step in the dissimilatory sulfate reduction pathway, using the enzyme purified from Desulfovibrio vulgaris Miyazaki. APS reductase carried out the one-step, two-electron reduction of APS to sulfite, without the production of other metabolic intermediates. Nearly identical isotope effects were obtained at two different temperatures, while the rate of APS reduction more than quadrupled with a temperature increase from 20 to 32°C. When placed in context of the linear network model for microbial sulfur isotope fractionation, our finding could provide a new, semi-quantitative constraint on the sulfur cycle at levels from cellular to global.

  3. Substructure based modeling of nickel single crystals cycled at low plastic strain amplitudes (United States)

    Zhou, Dong

    In this dissertation a meso-scale, substructure-based, composite single crystal model is fully developed from the simple uniaxial model to the 3-D finite element method (FEM) model with explicit substructures and further with substructure evolution parameters, to simulate the completely reversed, strain controlled, low plastic strain amplitude cyclic deformation of nickel single crystals. Rate-dependent viscoplasticity and Armstrong-Frederick type kinematic hardening rules are applied to substructures on slip systems in the model to describe the kinematic hardening behavior of crystals. Three explicit substructure components are assumed in the composite single crystal model, namely "loop patches" and "channels" which are aligned in parallel in a "vein matrix," and persistent slip bands (PSBs) connected in series with the vein matrix. A magnetic domain rotation model is presented to describe the reverse magnetostriction of single crystal nickel. Kinematic hardening parameters are obtained by fitting responses to experimental data in the uniaxial model, and the validity of uniaxial assumption is verified in the 3-D FEM model with explicit substructures. With information gathered from experiments, all control parameters in the model including hardening parameters, volume fraction of loop patches and PSBs, and variation of Young's modulus etc. are correlated to cumulative plastic strain and/or plastic strain amplitude; and the whole cyclic deformation history of single crystal nickel at low plastic strain amplitudes is simulated in the uniaxial model. Then these parameters are implanted in the 3-D FEM model to simulate the formation of PSB bands. A resolved shear stress criterion is set to trigger the formation of PSBs, and stress perturbation in the specimen is obtained by several elements assigned with PSB material properties a priori. Displacement increment, plastic strain amplitude control and overall stress-strain monitor and output are carried out in the user

  4. Investigation of single-cycle separation process based on forward and backward extractions of actinides and fission products

    International Nuclear Information System (INIS)

    Sasaki, Yuji; Tsubata, Yasuhiro; Shirasu, Noriko; Morita, Keisuke; Suzuki, Tomoya


    We have been developing a new partitioning method of high-level radioactive waste by the single-cycle extraction process. This process is composed of the extraction of actinides (An) and fission products (FP, e.g., Pd, Ru, Mo and Tc), and mutual separation by reverse extraction. The extractant employed in this process is required to extract soft, hard acid metals and oxonium anions simultaneously. The NTAamide (N,N,N',N',N”,N”,-hexaoctyl-nitrilotriacetamide) is one of the candidate extractants. After the extraction of An and FP, the mutual separation by reverse-extraction should be set up. Distribution ratios of Pd and Ru, which are obtained by NTAamide extraction, can be suppressed by masking agents, thiourea, systeine, diethylenetriamine, and trisaminoethylamine. The masking of Mo can be performed using methylimino-N,N'-diethylacetamide (MIDEA), NTAamide(C2) and iminodimethylphosphoric acid, and Re can be stripped using an aqueous phase with high pH. The information on extraction and masking for these metals will be utilized in the development of the single-cycle process. (author)

  5. Low cycle fatigue properties and microstructure evolution at 760 °C of a single crystal superalloy

    Directory of Open Access Journals (Sweden)

    Zhenxue Shi


    Full Text Available Low cycle fatigue (LCF behavior of a single crystal superalloy was investigated at 760 °C. Microstructure evolution and fracture mechanism were studied by scanning electron microscopy (SEM and transmission electron microscopy (TEM, respectively. The results show that the fatigue data fluctuation was small and the fatigue parameters of the alloy had been determined. On increasing the cyclic number, the alloy initially showed slight cyclic softening at the early two or three cycles and slowly hardened to some extent afterwards, then kept stable for the most of the remaining fatigue life. The LCF of the alloy at 760 °C can be attributed to the main elastic damage in fatigue processing. The initiation site of fatigue crack was at or near the surface of the samples. Crack propagated perpendicularly to the loading direction at first and then along {111} octahedral slip planes. The fatigue fracture mechanism was quasi-cleavage fracture. The γ′ phase morphology still maintained cubic shape after fracture. There were a number of slip bands shear the γ′ precipitates and γ matrix near the fracture surface of the specimen. The inhomogeneous deformation microstructure was developed by dislocation motion of cross-slip and a limited γ′ precipitate shearing by slip band, stacking faults or single dislocation was observed.

  6. Titan Orbiter Aerorover Mission (United States)

    Sittler Jr., E. C.; Acuna, M.; Burchell, M. J.; Coates, A.; Farrell, W.; Flasar, M.; Goldstein, B. E.; Gorevan, S.; Hartle, R. E.; Johnson, W. T. K.


    We propose a combined Titan orbiter and Titan Aerorover mission with an emphasis on both in situ and remote sensing measurements of Titan's surface, atmosphere, ionosphere, and magnetospheric interaction. The biological aspect of the Titan environment will be emphasized by the mission (i.e., search for organic materials which may include simple organics to 'amono' analogues of amino acids and possibly more complex, lightening detection and infrared, ultraviolet, and charged particle interactions with Titan's surface and atmosphere). An international mission is assumed to control costs. NASA will provide the orbiter, launch vehicle, DSN coverage and operations, while international partners will provide the Aerorover and up to 30% of the cost for the scientific instruments through collaborative efforts. To further reduce costs we propose a single PI for orbiter science instruments and a single PI for Aerorover science instruments. This approach will provide single command/data and power interface between spacecraft and orbiter instruments that will have redundant central DPU and power converter for their instruments. A similar approach could be used for the Aerorover. The mission profile will be constructed to minimize conflicts between Aerorover science, orbiter radar science, orbiter radio science, orbiter imaging science, and orbiter fields and particles (FP) science. Additional information is contained in the original extended abstract.

  7. Realistic kinetic loading of the jaw system during single chewing cycles: a finite element study. (United States)

    Martinez Choy, S E; Lenz, J; Schweizerhof, K; Schmitter, M; Schindler, H J


    Although knowledge of short-range kinetic interactions between antagonistic teeth during mastication is of essential importance for ensuring interference-free fixed dental reconstructions, little information is available. In this study, the forces on and displacements of the teeth during kinetic molar biting simulating the power stroke of a chewing cycle were investigated by use of a finite-element model that included all the essential components of the human masticatory system, including an elastic food bolus. We hypothesised that the model can approximate the loading characteristics of the dentition found in previous experimental studies. The simulation was a transient analysis, that is, it considered the dynamic behaviour of the jaw. In particular, the reaction forces on the teeth and joints arose from contact, rather than nodal forces or constraints. To compute displacements of the teeth, the periodontal ligament (PDL) was modelled by use of an Ogden material model calibrated on the basis of results obtained in previous experiments. During the initial holding phase of the power stroke, bite forces were aligned with the roots of the molars until substantial deformation of the bolus occurred. The forces tilted the molars in the bucco-lingual and mesio-distal directions, but as the intrusive force increased the teeth returned to their initial configuration. The Ogden material model used for the PDL enabled accurate prediction of the displacements observed in experimental tests. In conclusion, the comprehensive kinetic finite element model reproduced the kinematic and loading characteristics of previous experimental investigations. © 2017 John Wiley & Sons Ltd.

  8. A road map for the realization of global-scale thorium breeding fuel cycle by single molten-fluoride flow

    International Nuclear Information System (INIS)

    Furukawa, K.; Arakawa, K.; Erbay, L. B.


    For global survival in this century, we urgently need to launch a completely new global nuclear fission industry. To get worldwide public acceptance of nuclear energy, improvements are essential not only on safety, radio-waste management and economy but also especially nuclear proliferation resistance and safeguards. However, such global fission industry cannot replace the present fossil fuel industry in the next 50 years, unless the doubling-time of nuclear energy is less than 10 years, preferably 5-7 years. Such a doubling-time cannot be established by any kind of classical 'Fission Breeding Power Station' concept. We need a symbiotic system which couples fission power reactors with a system which can convert fertile thorium to fissile U-233, such as a spallation or D/T fusion (if and when it becomes available). For such a purpose, THORIMS-NES [Thorium Molten-Salt Nuclear Energy Synergetic System] has been proposed, which is composed of simple thermal fission power stations (FUJI) and fissile producing Accelerator Molten-Salt Breeder (AMSB). Its system functions are very ambitious, delicate and complex, but can be realized in the form of simple hardware applying the multifunctional 'single-phase molten-fluoride' circulation system. This system has no difficulties relating with 'radiation-damage', 'heat-removal' and 'chemical processing' owing to the simple 'idealistic ionic liquid' character. FUJI is size-flexible (economical even in smaller sizes), fuel self-sustaining without any continuous chemical processing and without core-graphite replacement, and AMSB is based on a single-fluid molten-salt target/blanket concept, which solves most engineering difficulties such as radiation-damage, heat-removal etc., except high-current proton accelerator development. Several AMSBs are accommodated in the regional centers (several ten sites in the world) with batch chemical processing plants including radio-waste management. The integrated thorium breeding fuel cycle is

  9. Sorting of cells of the same size, shape, and cell cycle stage for a single cell level assay without staining

    Directory of Open Access Journals (Sweden)

    Yomo Tetsuya


    Full Text Available Abstract Background Single-cell level studies are being used increasingly to measure cell properties not directly observable in a cell population. High-performance data acquisition systems for such studies have, by necessity, developed in synchrony. However, improvements in sample purification techniques are also required to reveal new phenomena. Here we assessed a cell sorter as a sample-pretreatment tool for a single-cell level assay. A cell sorter is routinely used for selecting one type of cells from a heterogeneous mixture of cells using specific fluorescence labels. In this case, we wanted to select cells of exactly the same size, shape, and cell-cycle stage from a population, without using a specific fluorescence label. Results We used four light scatter parameters: the peak height and area of the forward scatter (FSheight and FSarea and side scatter (SSheight and SSarea. The rat pheochromocytoma PC12 cell line, a neuronal cell line, was used for all experiments. The living cells concentrated in the high FSarea and middle SSheight/SSarea fractions. Single cells without cell clumps were concentrated in the low SS and middle FS fractions, and in the higher FSheight/FSarea and SSheight/SSarea fractions. The cell populations from these viable, single-cell-rich fractions were divided into twelve subfractions based on their FSarea-SSarea profiles, for more detailed analysis. We found that SSarea was proportional to the cell volume and the FSarea correlated with cell roundness and elongation, as well as with the level of DNA in the cell. To test the method and to characterize the basic properties of the isolated single cells, sorted cells were cultured in separate wells. The cells in all subfractions survived, proliferated and differentiated normally, suggesting that there was no serious damage. The smallest, roundest, and smoothest cells had the highest viability. There was no correlation between proliferation and differentiation. NGF increases

  10. The ATPase cross-bridge cycle of the Kar3 motor domain. Implications for single head motility. (United States)

    Mackey, Andrew T; Gilbert, Susan P


    Kar3 is a minus-end directed microtubule motor involved in meiosis and mitosis in Saccharomyces cerevisae. Unlike Drosophila Ncd, the other well characterized minus-end directed motor that is a homodimer, Kar3 is a heterodimer with a single motor domain and either the associated polypeptides Cik1 or Vik1. Our mechanistic studies with Ncd showed that both motor domains were required for ATP-dependent motor domain detachment from the microtubule. We have initiated a series of experiments to compare the mechanistic requirements for Kar3 motility in direct comparison to Ncd. The results presented here show that the single motor domain of Kar3 (Met(383)-Lys(729)) exhibits characteristics similar to monomeric Ncd. The microtubule-activated steady-state ATPase cycle of Kar3 (k(cat) = 0.5 s(-1)) is limited by ADP release (0.4 s(-1)). Like monomeric Ncd, Kar3 does not readily detach from the microtubule with the addition of MgATP. These results show that the single motor domain of Kar3 is not sufficient for ATP-dependent microtubule dissociation, suggesting that structural elements outside of the catalytic core are required for the cyclic interactions with the microtubule for force generation.

  11. Physiological responses to incremental, interval, and continuous counterweighted single-leg and double-leg cycling at the same relative intensities. (United States)

    MacInnis, Martin J; Morris, Nathaniel; Sonne, Michael W; Zuniga, Amanda Farias; Keir, Peter J; Potvin, Jim R; Gibala, Martin J


    We compared physiological responses to incremental, interval, and continuous counterweighted single-leg and double-leg cycling at the same relative intensities. The primary hypothesis was that the counterweight method would elicit greater normalized power (i.e., power/active leg), greater electromyography (EMG) responses, and lower cardiorespiratory demand. Graded-exercise tests performed by 12 men (age: 21 ± 2 years; BMI: 24 ± 3 kg/m 2 ) initially established that peak oxygen uptake ([Formula: see text]; 76 ± 8.4%), expired ventilation ([Formula: see text]; 71 ± 6.8%), carbon dioxide production ([Formula: see text]; 71 ± 6.8%), heart rate (HRpeak; 91 ± 5.3%), and power output (PPO; 56 ± 3.6%) were lower during single-leg compared to double-leg cycling (main effect of mode; p cycling were performed at greater absolute power outputs but lower normalized power outputs compared to single-leg cycling (p  0.05), but semitendinosus was activated to a greater extent for single-leg cycling (p = 0.005). Single-leg interval and continuous cycling elicited lower mean [Formula: see text], [Formula: see text], [Formula: see text], HR and ratings of perceived exertion compared to double-leg cycling (p cycling elicits lower cardiorespiratory and perceptual responses than double-leg cycling at greater normalized power outputs.

  12. Effects of single cycle binaural beat duration on auditory evoked potentials. (United States)

    Mihajloski, Todor; Bohorquez, Jorge; Özdamar, Özcan


    Binaural beat (BB) illusions are experienced as continuous central pulsations when two sounds with slightly different frequencies are delivered to each ear. It has been shown that steady-state auditory evoked potentials (AEPs) to BBs can be captured and investigated. The authors recently developed a new method of evoking transient AEPs to binaural beats using frequency modulated stimuli. This methodology was able to create single BBs in predetermined intervals with varying carrier frequencies. This study examines the effects of the BB duration and the frequency modulating component of the stimulus on the binaural beats and their evoked potentials. Normal hearing subjects were tested with a set of four durations (25, 50, 100, and 200 ms) with two stimulation configurations, binaural dichotic (binaural beats) and diotic (frequency modulation). The results obtained from the study showed that out of the given durations, the 100 ms beat, was capable of evoking the largest amplitude responses. The frequency modulation effect showed a decrease in peak amplitudes with increasing beat duration until their complete disappearance at 200 ms. Even though, at 200 ms, the frequency modulation effects were not present, the binaural beats were still perceived and captured as evoked potentials.

  13. Analysis of spin-Hamiltonian and molecular orbital coefficients of Cu2+ doped C8H11KO8 single crystal through EPR technique (United States)

    Juliet sheela, K.; Krishnan, S. Radha; Shanmugam, V. M.; Subramanian, P.


    Electron paramagnetic resonance (EPR) studies have been investigated at X-band microwave frequency on Cu2+ ion incorporated into the single crystal of potassium succinate-succinic acid (KSSA) at room temperature. The angular variation of the EPR spectra has shown two magnetically in-equivalent Cu2+ sites in the KSSA single crystal system. The spin Hamiltonian parameters g and A are determined which reveals that the site I and site II occupied in rhombic and axial local field symmetry around the impurity ion. Among the two paramagnetic impurity ions, sites one occupies at substituitional position in the place of monovalent cation (K+) in the crystal whereas the other enters in its lattice interstitially by the correlation of EPR and crystal structure data. From the calculated principle values gxx, gyy, gzz and Axx, Ayy, Azz of both the sites, the admixture coefficients and molecular orbital coefficients were evaluated which gives the information of ground state wave function and types of bonding of impurity ions with the ligands.

  14. Thermal and pseudoelastic cycling in Cu-14.1Al-4.2Ni (wt%) single crystals

    International Nuclear Information System (INIS)

    Gastien, R.; Corbellani, C.E.; Sade, M.; Lovey, F.C.


    Thermally and stress induced martensitic transformations between β and a mixture of martensitic structures, β' and γ', were studied in Cu-14.1Al-4.2Ni (wt%) single crystals. In this way information on the relative stability between β' and γ' martensites, compared to the β phase, was obtained. The measurement of electrical resistance as a function of temperature was used to follow the evolution of thermally induced transitions. The stress induced transformations were analyzed in the small temperature range at which the pseudoelastic behavior between β and a mixture of both martensites plays the main role. A clear inhibition of the γ' martensite is detected as the number of cycles increases, no matter which thermodynamic coordinate is varied to induce the phase transition, i.e., temperature or stress. An evaluation of the magnitude of the relative stabilization of the β' martensite compared with γ' was obtained by a suitably designed experiment

  15. Association between ABO blood type and live-birth outcomes in single-embryo transfer cycles. (United States)

    Pereira, Nigel; Patel, Hency H; Stone, Logan D; Christos, Paul J; Elias, Rony T; Spandorfer, Steven D; Rosenwaks, Zev


    To investigate the association between ABO blood type and live-birth outcomes in patients undergoing IVF with day 5 single-embryo transfer (SET). Retrospective cohort study. University-affiliated center. Normal responders, blood type and live birth, while controlling for confounders. Odds ratios (OR) with 95% confidence intervals (CI) for live birth were estimated. A total of 2,329 patients were included. The mean age of the study cohort was 34.6 ± 4.78 years. The distribution of blood types was as follows: A = 897 (38.5%); B = 397 (17.0%); AB = 120 (5.2%); and, O = 1,915 (39.3%) patients. There was no difference in the baseline demographics, ovarian stimulation, or embryo quality parameters between the blood types. The unadjusted ORs for live birth when comparing blood type A (referent) with blood types B, AB, and O were 0.96 (95% CI, 0.6-1.7), 0.72 (95% CI, 0.4-1.2), and 0.96 (95% CI. 0.6-1.7), respectively. The adjusted ORs for live birth remained not significant when comparing blood type A to blood types B, AB, and O individually. No difference in birth weight or gestational age at delivery was noted among the four blood types. Our findings suggest that ABO blood type is not associated with live-birth rate, birth weight, or gestational age at delivery in patients undergoing IVF with day 5 SET. Copyright © 2017 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  16. Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells (United States)

    Kowalczyk, Monika S.; Tirosh, Itay; Heckl, Dirk; Rao, Tata Nageswara; Dixit, Atray; Haas, Brian J.; Schneider, Rebekka K.; Wagers, Amy J.; Ebert, Benjamin L.; Regev, Aviv


    Both intrinsic cell state changes and variations in the composition of stem cell populations have been implicated as contributors to aging. We used single-cell RNA-seq to dissect variability in hematopoietic stem cell (HSC) and hematopoietic progenitor cell populations from young and old mice from two strains. We found that cell cycle dominates the variability within each population and that there is a lower frequency of cells in the G1 phase among old compared with young long-term HSCs, suggesting that they traverse through G1 faster. Moreover, transcriptional changes in HSCs during aging are inversely related to those upon HSC differentiation, such that old short-term (ST) HSCs resemble young long-term (LT-HSCs), suggesting that they exist in a less differentiated state. Our results indicate both compositional changes and intrinsic, population-wide changes with age and are consistent with a model where a relationship between cell cycle progression and self-renewal versus differentiation of HSCs is affected by aging and may contribute to the functional decline of old HSCs. PMID:26430063

  17. Communication: An improved linear scaling perturbative triples correction for the domain based local pair-natural orbital based singles and doubles coupled cluster method [DLPNO-CCSD(T) (United States)

    Guo, Yang; Riplinger, Christoph; Becker, Ute; Liakos, Dimitrios G.; Minenkov, Yury; Cavallo, Luigi; Neese, Frank


    In this communication, an improved perturbative triples correction (T) algorithm for domain based local pair-natural orbital singles and doubles coupled cluster (DLPNO-CCSD) theory is reported. In our previous implementation, the semi-canonical approximation was used and linear scaling was achieved for both the DLPNO-CCSD and (T) parts of the calculation. In this work, we refer to this previous method as DLPNO-CCSD(T0) to emphasize the semi-canonical approximation. It is well-established that the DLPNO-CCSD method can predict very accurate absolute and relative energies with respect to the parent canonical CCSD method. However, the (T0) approximation may introduce significant errors in absolute energies as the triples correction grows up in magnitude. In the majority of cases, the relative energies from (T0) are as accurate as the canonical (T) results of themselves. Unfortunately, in rare cases and in particular for small gap systems, the (T0) approximation breaks down and relative energies show large deviations from the parent canonical CCSD(T) results. To address this problem, an iterative (T) algorithm based on the previous DLPNO-CCSD(T0) algorithm has been implemented [abbreviated here as DLPNO-CCSD(T)]. Using triples natural orbitals to represent the virtual spaces for triples amplitudes, storage bottlenecks are avoided. Various carefully designed approximations ease the computational burden such that overall, the increase in the DLPNO-(T) calculation time over DLPNO-(T0) only amounts to a factor of about two (depending on the basis set). Benchmark calculations for the GMTKN30 database show that compared to DLPNO-CCSD(T0), the errors in absolute energies are greatly reduced and relative energies are moderately improved. The particularly problematic case of cumulene chains of increasing lengths is also successfully addressed by DLPNO-CCSD(T).

  18. Communication: An improved linear scaling perturbative triples correction for the domain based local pair-natural orbital based singles and doubles coupled cluster method [DLPNO-CCSD(T)

    KAUST Repository

    Guo, Yang


    In this communication, an improved perturbative triples correction (T) algorithm for domain based local pair-natural orbital singles and doubles coupled cluster (DLPNO-CCSD) theory is reported. In our previous implementation, the semi-canonical approximation was used and linear scaling was achieved for both the DLPNO-CCSD and (T) parts of the calculation. In this work, we refer to this previous method as DLPNO-CCSD(T0) to emphasize the semi-canonical approximation. It is well-established that the DLPNO-CCSD method can predict very accurate absolute and relative energies with respect to the parent canonical CCSD method. However, the (T0) approximation may introduce significant errors in absolute energies as the triples correction grows up in magnitude. In the majority of cases, the relative energies from (T0) are as accurate as the canonical (T) results of themselves. Unfortunately, in rare cases and in particular for small gap systems, the (T0) approximation breaks down and relative energies show large deviations from the parent canonical CCSD(T) results. To address this problem, an iterative (T) algorithm based on the previous DLPNO-CCSD(T0) algorithm has been implemented [abbreviated here as DLPNO-CCSD(T)]. Using triples natural orbitals to represent the virtual spaces for triples amplitudes, storage bottlenecks are avoided. Various carefully designed approximations ease the computational burden such that overall, the increase in the DLPNO-(T) calculation time over DLPNO-(T0) only amounts to a factor of about two (depending on the basis set). Benchmark calculations for the GMTKN30 database show that compared to DLPNO-CCSD(T0), the errors in absolute energies are greatly reduced and relative energies are moderately improved. The particularly problematic case of cumulene chains of increasing lengths is also successfully addressed by DLPNO-CCSD(T).

  19. Analysis of trace inorganic anions in weak acid salts by single pump cycling-column-switching ion chromatography. (United States)

    Huang, Zhongping; Ni, Chengzhu; Zhu, Zhuyi; Pan, Zaifa; Wang, Lili; Zhu, Yan


    The application of ion chromatography with the single pump cycling-column-switching technique was described for the analysis of trace inorganic anions in weak acid salts within a single run. Due to the hydrogen ions provided by an anion suppressor electrolyzing water, weak acid anions could be transformed into weak acids, existing as molecules, after passing through the suppressor. Therefore, an anion suppressor and ion-exclusion column were adopted to achieve on-line matrix elimination of weak acid anions with high concentration for the analysis of trace inorganic anions in weak acid salts. A series of standard solutions consisting of target anions of various concentrations from 0.005 to 10 mg/L were analyzed, with correlation coefficients r ≥ 0.9990. The limits of detection were in the range of 0.67 to 1.51 μg/L, based on the signal-to-noise ratio of 3 and a 25 μL injection volume. Relative standard deviations for retention time, peak area, and peak height were all less than 2.01%. A spiking study was performed with satisfactory recoveries between 90.3 and 104.4% for all anions. The chromatographic system was successfully applied to the analysis of trace inorganic anions in five weak acid salts. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Single-cell transcriptome sequencing reveals that cell division cycle 5-like protein is essential for porcine oocyte maturation. (United States)

    Liu, Xiao-Man; Wang, Yan-Kui; Liu, Yun-Hua; Yu, Xiao-Xia; Wang, Pei-Chao; Li, Xuan; Du, Zhi-Qiang; Yang, Cai-Xia


    The brilliant cresyl blue (BCB) test is used in both basic biological research and assisted reproduction to identify oocytes likely to be developmentally competent. However, the underlying molecular mechanism targeted by the BCB test is still unclear. To explore this question, we first confirmed that BCB-positive porcine oocytes had higher rates of meiotic maturation, better rates of cleavage and development into blastocysts, and lower death rates. Subsequent single-cell transcriptome sequencing on porcine germinal vesicle (GV)-stage oocytes identified 155 genes that were significantly differentially expressed between BCB-negative and BCB-positive oocytes. These included genes such as cdc5l , ldha , spata22 , rgs2 , paip1 , wee1b , and hsp27 , which are enriched in functionally important signaling pathways including cell cycle regulation, oocyte meiosis, spliceosome formation, and nucleotide excision repair. In BCB-positive GV oocytes that additionally had a lower frequency of DNA double-strand breaks, the CDC5L protein was significantly more abundant. cdc5l /CDC5L inhibition by short interference (si)RNA or antibody microinjection significantly impaired porcine oocyte meiotic maturation and subsequent parthenote development. Taken together, our single-oocyte sequencing data point to a potential new role for CDC5L in porcine oocyte meiosis and early embryo development, and supports further analysis of this protein in the context of the BCB test. © 2018 by The American Society for Biochemistry and Molecular Biology, Inc.

  1. [Orbital cellulitis]. (United States)

    Mouriaux, F; Rysanek, B; Babin, E; Cattoir, V


    Orbital cellulitis is uncommon in ophthalmologic practice. The majority of cases arise from direct spread of sinus infection or eyelid infection. Clinically, orbital cellulitis is divided into two forms: the preseptal form, anterior to the orbital septum, and the retroseptal form, posterior to the orbital septum. Management and prognosis differ widely between the two types. The retroseptal form or "true" orbital cellulitis is a severe disease with potentially disastrous consequences for vision and survival. Clinical examination and urgent CT scanning are indispensable for correct diagnosis, evaluation of severity, surgical planning and antibiotic selection. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

  2. A high-resolution benthic stable-isotope record for the South Atlantic: Implications for orbital-scale changes in Late Paleocene-Early Eocene climate and carbon cycling (United States)

    Littler, Kate; Röhl, Ursula; Westerhold, Thomas; Zachos, James C.


    The Late Paleocene and Early Eocene were characterized by warm greenhouse climates, punctuated by a series of rapid warming and ocean acidification events known as “hyperthermals”, thought to have been paced or triggered by orbital cycles. While these hyperthermals, such as the Paleocene Eocene Thermal Maximum (PETM), have been studied in great detail, the background low-amplitude cycles seen in carbon and oxygen-isotope records throughout the Paleocene-Eocene have hitherto not been resolved. Here we present a 7.7 million year (myr) long, high-resolution, orbitally-tuned, benthic foraminiferal stable-isotope record spanning the late Paleocene and early Eocene interval (∼52.5-60.5 Ma) from Ocean Drilling Program (ODP) Site 1262, South Atlantic. This high resolution (∼2-4 kyr) record allows the changing character and phasing of orbitally-modulated cycles to be studied in unprecedented detail as it reflects the long-term trend in carbon cycle and climate over this interval. The main pacemaker in the benthic oxygen-isotope (δ18O) and carbon-isotope (δ13C) records from ODP Site 1262, are the long (405 kyr) and short (100 kyr) eccentricity cycles, and precession (21 kyr). Obliquity (41 kyr) is almost absent throughout the section except for a few brief intervals where it has a relatively weak influence. During the course of the Early Paleogene record, and particularly in the latest Paleocene, eccentricity-paced negative carbon-isotope excursions (δ13C, CIEs) and coeval negative oxygen-isotope (δ18O) excursions correspond to low carbonate (CaCO3) and coarse fraction (%CF) values due to increased carbonate dissolution, suggesting shoaling of the lysocline and accompanied changes in the global exogenic carbon cycle. These negative CIEs and δ18O events coincide with maxima in eccentricity, with changes in δ18O leading changes in δ13C by ∼6 (±5) kyr in the 405-kyr band and by ∼3 (±1) kyr in the higher frequency 100-kyr band on average. However, these

  3. Life Cycle Assessment and Costing Methods for Device Procurement: Comparing Reusable and Single-Use Disposable Laryngoscopes. (United States)

    Sherman, Jodi D; Raibley, Lewis A; Eckelman, Matthew J


    Traditional medical device procurement criteria include efficacy and safety, ease of use and handling, and procurement costs. However, little information is available about life cycle environmental impacts of the production, use, and disposal of medical devices, or about costs incurred after purchase. Reusable and disposable laryngoscopes are of current interest to anesthesiologists. Facing mounting pressure to quickly meet or exceed conflicting infection prevention guidelines and oversight body recommendations, many institutions may be electively switching to single-use disposable (SUD) rigid laryngoscopes or overcleaning reusables, potentially increasing both costs and waste generation. This study provides quantitative comparisons of environmental impacts and total cost of ownership among laryngoscope options, which can aid procurement decision making to benefit facilities and public health. We describe cradle-to-grave life cycle assessment (LCA) and life cycle costing (LCC) methods and apply these to reusable and SUD metal and plastic laryngoscope handles and tongue blade alternatives at Yale-New Haven Hospital (YNHH). The US Environmental Protection Agency's Tool for the Reduction and Assessment of Chemical and other environmental Impacts (TRACI) life cycle impact assessment method was used to model environmental impacts of greenhouse gases and other pollutant emissions. The SUD plastic handle generates an estimated 16-18 times more life cycle carbon dioxide equivalents (CO2-eq) than traditional low-level disinfection of the reusable steel handle. The SUD plastic tongue blade generates an estimated 5-6 times more CO2-eq than the reusable steel blade treated with high-level disinfection. SUD metal components generated much higher emissions than all alternatives. Both the SUD handle and SUD blade increased life cycle costs compared to the various reusable cleaning scenarios at YNHH. When extrapolated over 1 year (60,000 intubations), estimated costs increased

  4. Quark Orbital Angular Momentum

    Directory of Open Access Journals (Sweden)

    Burkardt Matthias


    Full Text Available Definitions of orbital angular momentum based on Wigner distributions are used as a framework to discuss the connection between the Ji definition of the quark orbital angular momentum and that of Jaffe and Manohar. We find that the difference between these two definitions can be interpreted as the change in the quark orbital angular momentum as it leaves the target in a DIS experiment. The mechanism responsible for that change is similar to the mechanism that causes transverse single-spin asymmetries in semi-inclusive deep-inelastic scattering.

  5. Effect of menstrual cycle on frequency of alveolar osteitis in women undergoing surgical removal of mandibular third molar: a single-blind randomized clinical trial. (United States)

    Eshghpour, Majid; Rezaei, Naser Mohammadzadeh; Nejat, AmirHossein


    To measure the association between the menstrual cycle and the frequency of alveolar osteitis (AO). In a study with a single-blind design, patients with bilateral impacted third molar teeth underwent randomized surgical extraction: one tooth during the menstrual period and one during the middle of the cycle. The postoperative examiner was unaware of the menstrual cycle status of the patients. The predictor variable was the timing of the menstrual cycle and was grouped as mid-cycle and menstrual period. The outcome variable was AO, which was measured (without knowledge of the menstrual cycle timing) at 2 to 7 days postoperatively. Other study variables included oral contraceptive (OC) use, smoking status, irrigation used during surgery, extraction difficulty, surgeon experience, number of local anesthetic cartridges used, and patient age. Appropriate bi- and multivariate statistics were computed, and the level of statistical significance was set at P cycle than during the menstrual period inboth the OC users and nonusers (P menstrual period (P > .05). According to the results of the present study, the menstrual cycle could be a determinant risk factor in the frequency of AO. We recommend that elective procedures be performed during the menstrual period in both OC users and nonusers to eliminate the effect of cycle-related hormonal changes on the development of AO. Copyright © 2013 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  6. Glacial cycles

    DEFF Research Database (Denmark)

    Kaufmann, R. K.; Juselius, Katarina

    We use a statistical model, the cointegrated vector autoregressive model, to assess the degree to which variations in Earth's orbit and endogenous climate dynamics can be used to simulate glacial cycles during the late Quaternary (390 kyr-present). To do so, we estimate models of varying complexi...

  7. Phase quantification during pseudoelastic cycling of Cu-13.1Al-4.0Ni (wt.%) single-crystal shape memory alloys using neutron diffraction

    Energy Technology Data Exchange (ETDEWEB)

    Kannarpady, Ganesh K. [Smart Materials and MEMS Laboratory, Department of Applied Science, University of Arkansas at Little Rock, 2801 South University, ETAS 575, Little Rock, AR 72204-1099 (United States); Bhattacharyya, Abhijit [Smart Materials and MEMS Laboratory, Department of Applied Science, University of Arkansas at Little Rock, 2801 South University, ETAS 575, Little Rock, AR 72204-1099 (United States)], E-mail:; Wolverton, Mike [Smart Materials and MEMS Laboratory, Department of Applied Science, University of Arkansas at Little Rock, 2801 South University, ETAS 575, Little Rock, AR 72204-1099 (United States); Brown, Donald W. [Materials Science and Technology Division, Los Alamos National Laboratory, NM 87545 (United States); Vogel, Sven C. [Los Alamos Neutron Science Center, Los Alamos National Laboratory, NM 87545 (United States); Pulnev, Sergei [Department of Solid State Physics, Ioffe Physico-Technical Institute, St. Petersburg (Russian Federation)


    This paper reports on the pseudoelastic, isothermal mechanical cycling of copper-aluminium-nickel single-crystals. It was found that stress-free transformation temperatures at the end of 1000 stress cycles did not change, whereas the transformation stresses decreased by about 10%; otherwise, the overall strain of 7% imposed during a loading cycle was completely recovered at the end of 1000 cycles. Non-contact multi-video extensometry uncovered a significant spatial non-uniformity in the maximum strains attained in different sections of the wire. At the end of the 1000th cycle, the top and bottom sections demonstrated very similar maximum strains while the midsection demonstrated lower strain. Phase quantification of the midsection of the wire using neutron diffraction demonstrated an increase in the stabilization of austenite from 0% in the first cycle to about 60% in the 1000th cycle. The specific nature of the tests required by neutron diffraction also uncovered a creep-like response of the SMA. Preliminary investigation suggests that this 'pseudo-creep' is due to the motion of phase fronts during the phase transformation. Neutron diffraction has also confirmed that while the single crystallinity of the SMA is excellent at 175 deg. C, there is a spread in orientation of the cubic phase at 200 deg. C with respect to the axis of the wire that is estimated at 2.17 deg. This spread disappears/reappears on mechanical loading/unloading, but decreases permanently on cyclic loading.


    Directory of Open Access Journals (Sweden)

    Andrej Kansky


    Full Text Available Background. Orbit is involved in 40% of all facial fractures. There is considerable variety in severity, ranging from simple nondisplaced to complex comminuted fractures. Complex comminuted fractures (up to 20% are responsible for the majority of complications and unfavorable results. Orbital fractures are classified as internal orbital fractures, zygomatico-orbital fractures, naso-orbito-ethmoidal fractures and combined fractures. The ophtalmic sequelae of midfacial fractures are usually edema and ecchymosis of the soft tissues, subconjuctival hemorrhage, diplopia, iritis, retinal edema, ptosis, enophthalmos, ocular muscle paresis, mechanical restriction of ocular movement and nasolacrimal disturbances. More severe injuries such as optic nerve trauma and retinal detachments have also been reported. Within the wide range of orbital fractures small group of complex fractures causes most of the sequelae. Therefore identification of severe injuries and adequate treatment is of major importance. The introduction of craniofacial techniques made possible a wide exposure even of large orbital wall defects and their reconstruction by bone grafts. In spite of significant progress, repair of complex orbital wall defects remains a problem even for the experienced surgeons.Results. In 1999 121 facial injuries were treated at our department (Clinical Centre Ljubljana Dept. Of Maxillofacial and Oral Surgery. Orbit was involved in 65% of cases. Isolated inner orbital fractures presented 4% of all fractures. 17 (14% complex cases were treated, 5 of them being NOE, 5 orbital (frame and inner walls, 3 zygomatico-orbital, 2 FNO and 2 maxillo-orbital fractures.Conclusions. Final result of the surgical treatment depends on severity of maxillofacial trauma. Complex comminuted fractures are responsable for most of the unfavorable results and ocular function is often permanently damaged (up to 75% in these fractures.

  9. Relativistic electron beams driven by single-cycle laser pulses at kHz repetition rate (Conference Presentation) (United States)

    Faure, Jérôme; Guénot, Diego; Gustas, Dominykas; Vernier, Aline; Beaurepaire, Benoît; Böhle, Frederik; López-Martens, Rodrigo; Lifschitz, Agustin


    Laser-plasma accelerators are usually driven by 100-TW class laser systems with rather low repetition rates. However, recent years have seen the emergence of laser-plasma accelerators operating with kHz lasers and energies lower than 10 mJ. The high repetition-rate is particularly interesting for applications requiring high stability and high signal-to-noise ratio but lower energy electrons. For example, our group recently demonstrated that kHz laser-driven electron beams could be used to capture ultrafast structural dynamics in Silicon nano-membranes via electron diffraction with picosecond resolution. In these first experiments, electrons were injected in the density gradients located at the plasma exit, resulting in rather low energies in the 100 keV range. The electrons being nonrelativistic, the bunch duration quickly becomes picosecond long. Relativistic energies are required to mitigate space charge effects and maintain femtosecond bunches. In this paper, we will show very recent results where electrons are accelerated in laser-driven wakefields to relativistic energies, reaching up to 5 MeV at kHz repetition rate. The electron energy was increased by nearly two orders of magnitude by using single-cycle laser pulses of 3.5 fs, with only 2.5 mJ of energy. Using such short pulses of light allowed us to resonantly excite high amplitude and nonlinear plasma waves at high plasma density, ne=1.5-2×1020 cm-3, in a regime close to the blow-out regime. Electrons had a peaked distribution around 5 MeV, with a relative energy spread of 30 %. Charges in the 100's fC/shot and up to pC/shot where measured depending on plasma density. The electron beam was fairly collimated, 20 mrad divergence at Full Width Half Maximum. The results show remarkable stability of the beam parameters in terms of beam pointing and electron distribution. 3D PIC simulations reproduce the results very well and indicate that electrons are injected by the ionization of Nitrogen atoms, N5+ to N6

  10. Orbital velocity


    Modestino, Giuseppina


    The trajectory and the orbital velocity are determined for an object moving in a gravitational system, in terms of fundamental and independent variables. In particular, considering a path on equipotential line, the elliptical orbit is naturally traced, verifying evidently the keplerian laws. The case of the planets of the solar system is presented.


    African Journals Online (AJOL)

    Aim: The purpose of this study was to assess the prevalence of paranasal sinusitis as a cause of orbital cellulitis and to identify the commonest sinus(es) involved in our setting. Methods: A retrospective review of the case notes of 47 patients with orbital cellulitis admitted into the ophthalmic ward of the University College ...

  12. Patient and cycle characteristics predicting high pregnancy rates with single-embryo transfer: an analysis of the Society for Assisted Reproductive Technology outcomes between 2004 and 2013. (United States)

    Mersereau, Jennifer; Stanhiser, Jamie; Coddington, Charles; Jones, Tiffany; Luke, Barbara; Brown, Morton B


    To analyze factors associated with high live birth rate and low multiple birth rate in fresh and frozen-thawed assisted reproductive technology (ART) cycles. Retrospective cohort analysis. Not applicable. The study population included 181,523 women undergoing in vitro fertilization with autologous fresh first cycles, 27,033 with fresh first oocyte donor cycles, 37,658 with fresh second cycles, and 35,446 with frozen-thawed second cycles. None. Live birth rate and multiple birth rate after single-embryo transfer (SET) and double embryo transfer (DET) were measured, in addition to cycle characteristics. In patients with favorable prognostic factors, including younger maternal age, transfer of a blastocyst, and additional embryos cryopreserved, the gain in the live birth rate from SET to DET was approximately 10%-15%; however, the multiple birth rate increased from approximately 2% to greater than 49% in both autologous and donor fresh and frozen-thawed transfer cycles. This study reports a 10%-15% reduction in live birth rate and a 47% decrement in multiple birth rate with SET compared with DET in the setting of favorable patient prognostic factors. Our findings present an opportunity to increase the rate of SET across the United States and thereby reduce the multiple birth rate and its associated poor perinatal outcomes with assisted reproductive technology pregnancies. Copyright © 2017 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  13. The Hot Orbit: Orbital Cellulitis (United States)

    Chaudhry, Imtiaz A.; Al-Rashed, Waleed; Arat, Yonca O.


    Orbital cellulitis is an uncommon condition previously associated with severe complications. If untreated, orbital cellulitis can be potentially sight and life threatening. It can affect both adults and children but has a greater tendency to occur in the pediatric age group. The infection most commonly originates from sinuses, eyelids or face, retained foreign bodies, or distant soources by hematogenous spread. It is characterized by eyelid edema, erythema, chemosis, proptosis, blurred vision, fever, headache, and double vision. A history of upper respiratory tract infection prior to the onset is very common especially in children. In the era prior to antibiotics, vision loss from orbital cellulitis was a dreaded complication. Currently, imaging studies for detection of orbital abcess, the use of antibiotics and early drainage have mitigated visual morbidity significantly. The purpose of this review is to describe current investigative strategies and management options in the treatment of orbital cellulitis, establish their effectiveness and possible complications due to late intervention. PMID:22346113

  14. Compendium of Single Event Effects (SEE) Test Results for COTS and Standard Electronics for Low Earth Orbit and Deep Space Applications (United States)

    Reddell, Brandon; Bailey, Chuck; Nguyen, Kyson; O'Neill, Patrick; Gaza, Razvan; Patel, Chirag; Cooper, Jaime; Kalb, Theodore


    We present the results of SEE testing with high energy protons and with low and high energy heavy ions. This paper summarizes test results for components considered for Low Earth Orbit and Deep Space applications.

  15. A Collaborative Analysis Tool for Integrated Hypersonic Aerodynamics, Thermal Protection Systems, and RBCC Engine Performance for Single Stage to Orbit Vehicles (United States)

    Stanley, Thomas Troy; Alexander, Reginald; Landrum, Brian


    Presented is a computer-based tool that connects several disciplines that are needed in the complex and integrated design of high performance reusable single stage to orbit (SSTO) vehicles. Every system is linked to every other system, as is the case of SSTO vehicles with air breathing propulsion, which is currently being studied by NASA. An RBCC propulsion system integrates airbreathing and rocket propulsion into a single engine assembly enclosed within a cowl or duct. A typical RBCC propulsion system operates as a ducted rocket up to approximately Mach 3. Then there is a transition to a ramjet mode for supersonic-to-hypersonic acceleration. Around Mach 8 the engine transitions to a scramjet mode. During the ramjet and scramjet modes, the integral rockets operate as fuel injectors. Around Mach 10-12 (the actual value depends on vehicle and mission requirements), the inlet is physically closed and the engine transitions to an integral rocket mode for orbit insertion. A common feature of RBCC propelled vehicles is the high degree of integration between the propulsion system and airframe. At high speeds the vehicle forebody is fundamentally part of the engine inlet, providing a compression surface for air flowing into the engine. The compressed air is mixed with fuel and burned. The combusted mixture must be expanded to an area larger than the incoming stream to provide thrust. Since a conventional nozzle would be too large, the entire lower after body of the vehicle is used as an expansion surface. Because of the high external temperatures seen during atmospheric flight, the design of an airbreathing SSTO vehicle requires delicate tradeoffs between engine design, vehicle shape, and thermal protection system (TPS) sizing in order to produce an optimum system in terms of weight (and cost) and maximum performance. To adequately determine the performance of the engine/vehicle, the Hypersonic Flight Inlet Model (HYFIM) module was designed to interface with the RBCC

  16. Foreign body orbital cyst

    DEFF Research Database (Denmark)

    Yazdanfard, Younes; Heegard, Steffen; Fledelius, Hans C.


    Ophthalmology, penetrating orbital injury, orbital foreign body, ultrasound, computed tomography (CT), histology......Ophthalmology, penetrating orbital injury, orbital foreign body, ultrasound, computed tomography (CT), histology...

  17. Beat-to-Beat Variation in Periodicity of Local Calcium Releases Contributes to Intrinsic Variations of Spontaneous Cycle Length in Isolated Single Sinoatrial Node Cells.

    Directory of Open Access Journals (Sweden)

    Oliver Monfredi

    Full Text Available Spontaneous, submembrane local Ca(2+ releases (LCRs generated by the sarcoplasmic reticulum in sinoatrial nodal cells, the cells of the primary cardiac pacemaker, activate inward Na(+/Ca(2+-exchange current to accelerate the diastolic depolarization rate, and therefore to impact on cycle length. Since LCRs are generated by Ca(2+ release channel (i.e. ryanodine receptor openings, they exhibit a degree of stochastic behavior, manifested as notable cycle-to-cycle variations in the time of their occurrence.The present study tested whether variation in LCR periodicity contributes to intrinsic (beat-to-beat cycle length variability in single sinoatrial nodal cells.We imaged single rabbit sinoatrial nodal cells using a 2D-camera to capture LCRs over the entire cell, and, in selected cells, simultaneously measured action potentials by perforated patch clamp.LCRs begin to occur on the descending part of the action potential-induced whole-cell Ca(2+ transient, at about the time of the maximum diastolic potential. Shortly after the maximum diastolic potential (mean 54±7.7 ms, n = 14, the ensemble of waxing LCR activity converts the decay of the global Ca(2+ transient into a rise, resulting in a late, whole-cell diastolic Ca(2+ elevation, accompanied by a notable acceleration in diastolic depolarization rate. On average, cells (n = 9 generate 13.2±3.7 LCRs per cycle (mean±SEM, varying in size (7.1±4.2 µm and duration (44.2±27.1 ms, with both size and duration being greater for later-occurring LCRs. While the timing of each LCR occurrence also varies, the LCR period (i.e. the time from the preceding Ca(2+ transient peak to an LCR's subsequent occurrence averaged for all LCRs in a given cycle closely predicts the time of occurrence of the next action potential, i.e. the cycle length.Intrinsic cycle length variability in single sinoatrial nodal cells is linked to beat-to-beat variations in the average period of individual LCRs each cycle.

  18. Low-cycle fatigue and damage of an uncoated and coated single crystal nickel-base superalloy SCB

    International Nuclear Information System (INIS)

    Stekovic, S.; Ericsson, T.


    This paper presents low-cycle fatigue (LCF) behaviour and damage mechanisms of uncoated and coated specimens of a single crystal nickel-base superalloy SCB tested at 500 C and 900 C. Four coatings were deposited on the base material, an overlay coating AMDRY997, a platinum-modified aluminide diffusion coating RT22 and two innovative coatings called IC1 and IC3 with a NiW diffusion barrier in the interface. AMDRY997 and RT22 were used as reference coatings. The LCF tests were performed at three strain amplitudes, 1.0, 1.2 and 1.4%, with R = -1, in laboratory air and without any dwell time. The LCF life of the specimens is determined by crack initiation and propagation. Crack data are presented for different classes of crack size in the form of crack density, that is, the number of cracks normalised to the investigated interface length. Micrographs of damage of the coatings are also shown. The effect of the coatings on the LCF life of the superalloy was dependent on the test temperature and deposited coating. At 500 C all coatings had a detrimental effect on the LCF life of the superalloy. At 900 C both AMDRY997 and IC1 prolonged the fatigue life of the superalloy by factors ranging between 1.5 and 4 while RT22 and IC3 shortened the life of the coating-substrate system. Specimens coated with RT22 exhibited generally more damage than other tested coatings at 900 C. Most of the cracks observed initiated at the coating surface and a majority were arrested in the interdiffusion zone between the base material and the coating. No topologically close-packed phases were found. Delamination was only found in AMDRY997 at higher strains. Surface roughness or rumpling was found in the overlay coating AMDRY997 with some cracks initiating from the rumples. The failure morphology at 900 C reflected the role of oxidation in the fatigue life, the crack initiation and propagation of the coated specimens. The wake of the cracks grown into the substrate was severely oxidised leading to

  19. Application of a high-repetition-rate laser diagnostic system for single-cycle-resolved imaging in internal combustion engines. (United States)

    Hult, Johan; Richter, Mattias; Nygren, Jenny; Aldén, Marcus; Hultqvist, Anders; Christensen, Magnus; Johansson, Bengt


    High-repetition-rate laser-induced fluorescence measurements of fuel and OH concentrations in internal combustion engines are demonstrated. Series of as many as eight fluorescence images, with a temporal resolution ranging from 10 micros to 1 ms, are acquired within one engine cycle. A multiple-laser system in combination with a multiple-CCD camera is used for cycle-resolved imaging in spark-ignition, direct-injection stratified-charge, and homogeneous-charge compression-ignition engines. The recorded data reveal unique information on cycle-to-cycle variations in fuel transport and combustion. Moreover, the imaging system in combination with a scanning mirror is used to perform instantaneous three-dimensional fuel-concentration measurements.

  20. GridOrbit public display

    DEFF Research Database (Denmark)

    Ramos, Juan David Hincapie; Tabard, Aurélien; Bardram, Jakob


    We introduce GridOrbit, a public awareness display that visualizes the activity of a community grid used in a biology laboratory. This community grid executes bioin-formatics algorithms and relies on users to donate CPU cycles to the grid. The goal of GridOrbit is to create a shared awareness about...... people comment on projects. Our work explores the usage of interactive technologies as enablers for the appropriation of an otherwise invisible infrastructure....

  1. High space velocities of single radio pulsars versus low orbital eccentricities and masses of double neutron stars: Evidence for two different neutron star formation mechanisms

    NARCIS (Netherlands)

    van den Heuvel, E.P.J.


    Radio pulsars tend to be high-velocity objects, which implies that the majority of them received a velocity kick of several hundreds of km s(-1) at birth. However, six of the eight known double neutron stars in the galactic disk have quite low orbital eccentricities (0.085-0.27), indicating - taking

  2. [Orbital exenteration]. (United States)

    Benazzou, S; Arkha, Y; Boulaadas, M; Essakalli, L; Kzadri, M


    Orbital exenteration is a disfiguring surgery. The surgery is mostly performed for advanced neoplasms of the eyelid in an attempt to achieve cure with tumor free margins. Reconstruction is a real challenge, especially in elderly patients with significant comorbidities. We operated 15 patients presenting with palpebral and orbital tumors, between January 2000 and December 2007. We collected the clinical data concerning patients, tumor, treatment, and recurrences. Ten male and five female patients with a mean age of 56 years at diagnosis presented with ulcerative palpebral malignant tumor, and impaired ocular motility. Basal cell carcinoma was the most common (80%). All patients underwent exenteration, (subtotal three, total eight, and extended four patients). The cavity was filled with a temporal muscle flap in ten cases, Mustardé flap in three cases, latissimus dorsi myocutaneous free flap in one case, and a jugal V-Y flap in one case. The mean follow-up was 23 months with good healing without radiotherapy tissue alteration. Four patients had a recurrence and one patient died from metastases. The goals of reconstruction are functional and esthetic. Given the initial tumoral extension, we choose to use a regional or microsurgical flap for functional reconstruction. The flap provides a good cutaneous coverage, rapid healing, closure of orbital nasal and sinus communications, or of orbital and cranial communications. It is not damaged by radiotherapy. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

  3. Preliminary GPS orbit determination results for the Extreme Ultraviolet Explorer (United States)

    Gold, Kenn; Bertiger, Willy; Wu, Sien; Yunck, Tom


    A single-frequency Motorola Global Positioning System (GPS) receiver was launched with the Extreme Ultraviolet Explorer mission in June 1992. The receiver utilizes dual GPS antennas placed on opposite sides of the satellite to obtain full GPS coverage as it rotates during its primary scanning mission. A data set from this GPS experiment has been processed at the Jet Propulsion Laboratory with the GIPSY-OASIS 2 software package. The single-frequency, dual antenna approach and the low altitude (approximately 500 km) orbit of the satellite create special problems for the GPS orbit determination analysis. The low orbit implies that the dynamics of the spacecraft will be difficult to model, and that atmospheric drag will be an important error source. A reduced-dynamic solution technique was investigated in which ad hoc accelerations were estimated at each time step to absorb dynamic model error. In addition, a single-frequency ionospheric correction was investigated, and a cycle-slip detector was written. Orbit accuracy is currently better than 5 m. Further optimization should improve this to about 1 m.

  4. Cytotoxicity and cell-cycle effects of paclitaxel when used as a single agent and in combination with ionizing radiation

    International Nuclear Information System (INIS)

    Gupta, Nalin; Hu, Lily J.; Deen, Dennis F.


    Purpose: This study aimed to determine the extent of paclitaxel-induced cytotoxicity and cell-cycle perturbations when used alone and in combination with radiation in human glioma cells. Methods and Materials: The effect of paclitaxel alone on three human glioma cells lines--SF-126, U-87 MG, and U-251 MG--was assessed after 24, 48, 72, or 96 h treatment. For experiments in combination with radiation, cells were exposed to either a long (48-h) or short (8-h) duration of paclitaxel treatment prior to irradiation. Cell survival was determined by clonogenic assay. Cell cycle perturbations were assessed by using flow cytometry to measure the proportion of cells in G 1 , S, and G 2 /M phases. Results: When cells were treated with paclitaxel alone for ≥24 h, cytotoxicity increased up to a threshold dose, after which it plateaued. When treatment duration was ≤24 h, cytotoxicity was appreciably greater in U-251 MG cells than in SF-126 and U-87 MG cells. After 24 h of paclitaxel treatment, cells in plateau phase growth had increased survival compared to cells in log phase growth. In contrast, after 8 h paclitaxel treatment, mitotic cells had reduced survival compared to cells from an asynchronous population. Cell-cycle perturbations were consistent with the presence of a mitotic block after paclitaxel treatment, although changes in other cell-cycle phase fractions varied among cell lines. For experiments in combination with radiation, cytotoxicity was increased when cells were irradiated after 48 h of paclitaxel treatment but not after 8 h of treatment. Conclusion: The duration of paclitaxel treatment and the location of cells in the cell cycle modify the degree of radiation cytotoxicity. The mechanisms of paclitaxel cytotoxicity are likely to be multifactorial because varying effects are seen in different cell lines. Furthermore, it is clear that simply increasing the number of cells in G 2 /M is insufficient in itself to increase the response of cells to radiation

  5. Study on cycle-slip detection and repair methods for a single dual-frequency global positioning system (GPS receiver

    Directory of Open Access Journals (Sweden)

    La Van Hieu

    Full Text Available In this work, we assessed the performance of the cycle-slip detection methods: Turbo Edit (TE, Melbourne-Wübbena wide-lane ambiguity (MWWL and forward and backward moving window averaging (FBMWA. The TE and MWWL methods were combined with ionospheric total electron content rate (TECR, and the FBMWA with second-order time-difference phase ionosphere residual (STPIR and TECR. Under different scenarios, 10 Global Positioning System (GPS datasets were used to assess the performance of the methods for cycle-slip detection. The MWWL-TECR delivered the best performance in detecting cycle-slips for 1 s data. The relative comparisons show that the FBMWA-TECR method performed slightly better than its original version, FBMWA-STPIR, detecting 100% and 73%, respectively. For data with a sample rate of 5 s, the FBMWA-TECR performed better than MWWL-TECR. However, the FBMWA is suitable only for post-processing, which refers to applications where the data are processed after the fact.

  6. Experimental study of the rearrangements of valence protons and neutrons amongst single-particle orbits during double- β decay in Mo100

    Energy Technology Data Exchange (ETDEWEB)

    Freeman, S. J.; Sharp, D. K.; McAllister, S. A.; Kay, B. P.; Deibel, C. M.; Faestermann, T.; Hertenberger, R.; Mitchell, A. J.; Schiffer, J. P.; Szwec, S. V.; Thomas, J. S.; Wirth, H. -F.


    The rearrangements of protons and neutrons amongst the valence single-particle orbitals during double-beta decay of Mo-100 have been determined by measuring cross sections in (d, p), (p, d), (He-3, a), and (He-3, d) reactions on Mo-98,Mo-100 and Ru-100,Ru-102 targets. The deduced nucleon occupancies reveal significant discrepancies when compared with theoretical calculations; the same calculations have previously been used to determine the nuclear matrix element associated with the decay probability of double-beta decay of the Mo-100 system.

  7. A σ-T diagram analysis regarding the γ' inhibition in β ↔ β' + γ' cycling in CuAlNi single crystals

    International Nuclear Information System (INIS)

    Gastien, R.; Corbellani, C.E.; Sade, M.; Lovey, F.C.


    An effect of inhibition of the γ' martensitic structure in thermal and pseudoelastic β ↔ β' + γ' cycling in CuAlNi single crystals was reported previously [Gastien R, Corbellani CE, Alvarez Villar HN, Sade M, Lovey FC. Mater Sci Eng A 2003;349:191], and an experiment to determine the new thermodynamic parameters to obtain the stress-induced γ' structure was performed [Gastien R, Corbellani CE, Sade M, Lovey FC. Acta Mater 2005;53:1685]. In this paper, a thermodynamic analysis of this effect using σ-T diagrams is proposed, in order to obtain a proper estimation of the energy involved in the inhibition process for pseudoelastic β ↔ β' + γ' cycling

  8. Computer code for single-point thermodynamic analysis of hydrogen/oxygen expander-cycle rocket engines (United States)

    Glassman, Arthur J.; Jones, Scott M.


    This analysis and this computer code apply to full, split, and dual expander cycles. Heat regeneration from the turbine exhaust to the pump exhaust is allowed. The combustion process is modeled as one of chemical equilibrium in an infinite-area or a finite-area combustor. Gas composition in the nozzle may be either equilibrium or frozen during expansion. This report, which serves as a users guide for the computer code, describes the system, the analysis methodology, and the program input and output. Sample calculations are included to show effects of key variables such as nozzle area ratio and oxidizer-to-fuel mass ratio.

  9. Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus

    DEFF Research Database (Denmark)

    Russell, Rodney S; Meunier, Jean-Christophe; Takikawa, Shingo


    mutations that were selected during serial passage in Huh-7.5 cells were studied. Recombinant genomes containing all five mutations produced 3-4 logs more infectious virions than did wild type. Neither a coding mutation in NS5A nor a silent mutation in E2 was adaptive, whereas coding mutations in E2, p7......The JFH1 strain of hepatitis C virus (HCV) is unique among HCV isolates, in that the wild-type virus can traverse the entire replication cycle in cultured cells. However, without adaptive mutations, only low levels of infectious virus are produced. In the present study, the effects of five...

  10. Cumulative results including obstetrical and neonatal outcome of fresh and frozen-thawed cycles in elective single versus double fresh embryo transfers. (United States)

    Fauque, Patricia; Jouannet, Pierre; Davy, Céline; Guibert, Juliette; Viallon, Vivian; Epelboin, Sylvie; Kunstmann, Jean-Marie; Patrat, Catherine


    To assess the efficacy of elective single embryo transfer (e-SET) compared to a double embryo transfer (DET) in a selected population including obstetrical and neonatal outcome of fresh and frozen-thawed cycles. Prospective nonrandomized study. Department of reproductive medicine. Elective single embryo transfer was proposed to women 0.05). Twin delivery rate was significantly different between the two groups (3.5% versus 37.5% respectively, P<0.05). Neonatal outcome in twins resulting from IVF-ICSI was found to be poorer than in singletons, considering the mean gestational age, mode of delivery, birthweight, and risk of neonatal intensive care unit admission for the infants. In a selected population, the elective transfer of one embryo with high implantation potential helped to avoid twin pregnancies without decreasing delivery rate. Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  11. Inflammation of the Orbit (United States)

    ... Glaucoma (Video) Macular Degeneration Additional Content Medical News Inflammation of the Orbit (Inflammatory Orbital Pseudotumor) By James ... Introduction to Eye Socket Disorders Cavernous Sinus Thrombosis Inflammation of the Orbit Orbital Cellulitis Preseptal Cellulitis Tumors ...

  12. HiHiMap: single-cell quantitation of histones and histone posttranslational modifications across the cell cycle by high-throughput imaging. (United States)

    Zane, Linda; Chapus, Fleur; Pegoraro, Gianluca; Misteli, Tom


    We describe Hi gh-throughput Hi stone Map ping (HiHiMap), a high-throughput imaging method to measure histones and histone posttranslational modifications (PTMs) in single cells. HiHiMap uses imaging-based quantification of DNA and cyclin A to stage individual cells in the cell cycle to determine the levels of histones or histone PTMs in each stage of the cell cycle. As proof of principle, we apply HiHiMap to measure the level of 21 core histones, histone variants, and PTMs in primary, immortalized, and transformed cells. We identify several histone modifications associated with oncogenic transformation. HiHiMap allows the rapid, high-throughput study of histones and histone PTMs across the cell cycle and the study of subpopulations of cells. © 2017 Zane et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (

  13. MOOSE: Manned On-Orbit Servicing Equipment (United States)

    Budinoff, J.; Leontsinis, N.; Lane, J.; Singh, R.; Angelone, K.; Boswell, C.; Chamberlain, I.; Concha, M.; Corrodo, M.; Custodio, O.

    The ability to service satellites has thus far been limited to low earth orbit platforms within reach of the Space Shuttle. Other orbits, such as geosynchronous orbits containing high-value spacecraft have not been attainable by a servicing vehicle. The useful life of a satellite can be extended by replacing spent propellant and damaged orbital replacement units, forestalling the need for eventual replacement. This growing need for satellite on-orbits servicing can be met by the Manned On-Orbit Servicing Equipment (MOOSE). Missions requiring orbit transfer capability, precision manipulation and maneuvering, and man-in-the-loop control can be accomplished using MOOSE. MOOSE is a flexible, reusable, single operator, aerobraking spacecraft designed to refuel, repair, and service orbiting spacecraft. MOOSE will be deployed from Space Station Freedom, (SSF), where it will be stored, resupplied, and refurbished.

  14. Effects of single dose GnRH agonist as luteal support on pregnancy outcome in frozen-thawed embryo transfer cycles: an RCT

    Directory of Open Access Journals (Sweden)

    Robab Davar


    Full Text Available Background: There is no doubt that luteal phase support is essential to enhance the reproductive outcome in IVF cycles. In addition to progesterone and human chorionic gonadotropin, several studies have described GnRH agonists as luteal phase support to improve implantation rate, pregnancy rate and live birth rate, whereas other studies showed dissimilar conclusions. All of these studies have been done in fresh IVF cycles. Objective: To determine whether an additional GnRH agonist administered at the time of implantation for luteal phase support in frozen-thawed embryo transfer (FET improves the embryo developmental potential. Materials and Methods: This is a prospective controlled trial study in 200 FET cycles, patients were randomized on the day of embryo transfer into group 1 (n=100 to whom a single dose of GnRH agonist (0.1 mg triptorelin was administered three days after transfer and group 2 (n=100, who did not receive agonist. Both groups received daily vaginal progesterone suppositories plus estradiol valerate 6 mg daily. Primary outcome measure was clinical pregnancy rate. Secondary outcome measures were implantation rate, chemical, ongoing pregnancy rate and abortion rate. Results: A total of 200 FET cycles were analyzed. Demographic data and embryo quality were comparable between two groups. No statistically significant difference in clinical and ongoing pregnancy rates was observed between the two groups (26% versus 21%, p=0.40 and 21% versus 17%, p=0.37, respectively. Conclusion: Administration of a subcutaneous GnRH agonist at the time of implantation does not increase clinical or ongoing pregnancy.

  15. Scanning Electron Microscopy Analysis of the Adaptation of Single-Unit Screw-Retained Computer-Aided Design/Computer-Aided Manufacture Abutments After Mechanical Cycling. (United States)

    Markarian, Roberto Adrian; Galles, Deborah Pedroso; Gomes França, Fabiana Mantovani

    To measure the microgap between dental implants and custom abutments fabricated using different computer-aided design/computer-aided manufacture (CAD/CAM) methods before and after mechanical cycling. CAD software (Dental System, 3Shape) was used to design a custom abutment for a single-unit, screw-retained crown compatible with a 4.1-mm external hexagon dental implant. The resulting stereolithography file was sent for manufacturing using four CAD/CAM methods (n = 40): milling and sintering of zirconium dioxide (ZO group), cobalt-chromium (Co-Cr) sintered via selective laser melting (SLM group), fully sintered machined Co-Cr alloy (MM group), and machined and sintered agglutinated Co-Cr alloy powder (AM group). Prefabricated titanium abutments (TI group) were used as controls. Each abutment was placed on a dental implant measuring 4.1× 11 mm (SA411, SIN) inserted into an aluminum block. Measurements were taken using scanning electron microscopy (SEM) (×4,000) on four regions of the implant-abutment interface (IAI) and at a relative distance of 90 degrees from each other. The specimens were mechanically aged (1 million cycles, 2 Hz, 100 N, 37°C) and the IAI width was measured again using the same approach. Data were analyzed using two-way analysis of variance, followed by the Tukey test. After mechanical cycling, the best adaptation results were obtained from the TI (2.29 ± 1.13 μm), AM (3.58 ± 1.80 μm), and MM (1.89 ± 0.98 μm) groups. A significantly worse adaptation outcome was observed for the SLM (18.40 ± 20.78 μm) and ZO (10.42 ± 0.80 μm) groups. Mechanical cycling had a marked effect only on the AM specimens, which significantly increased the microgap at the IAI. Custom abutments fabricated using fully sintered machined Co-Cr alloy and machined and sintered agglutinated Co-Cr alloy powder demonstrated the best adaptation results at the IAI, similar to those obtained with commercial prefabricated titanium abutments after mechanical cycling. The

  16. Orbital flower (United States)

    Szucs-Csillik, Iharka


    The regularizing techniques known as Kustaanheimo-Stiefel (KS) transformation have investigated. It has proved that it is very useful in n-body simulations, where it helps to handle close encounters. This paper shows how the basic transformation is a starting point for a family of polynomial coupled function. This interpretation becomes simply on writing KS transformations in quaternion form, which also helps to derive concise expressions for regularized equations of motion. Even if the KS regularization method is more easy to use, it is interesting to encapsulate the KS transformation in a family of methods, which all conserve the KS transformations' properties. Further, an interesting point of view is considering, the orbital shapes of the restricted three-body problem (also regularized restricted three-body problem) for different initial conditions has compared with flower pattern.

  17. Systems Level Dissection of Anaerobic Methane Cycling: Quantitative Measurements of Single Cell Ecophysiology, Genetic Mechanisms, and Microbial Interactions

    Energy Technology Data Exchange (ETDEWEB)

    Orphan, Victoria [California Inst. of Technology (CalTech), Pasadena, CA (United States); Tyson, Gene [University of Queensland, Brisbane Australia; Meile, Christof [University of Georgia, Athens, Georgia; McGlynn, Shawn [California Inst. of Technology (CalTech), Pasadena, CA (United States); Yu, Hang [California Inst. of Technology (CalTech), Pasadena, CA (United States); Chadwick, Grayson [California Inst. of Technology (CalTech), Pasadena, CA (United States); Marlow, Jeffrey [California Inst. of Technology (CalTech), Pasadena, CA (United States); Trembath-Reichert, Elizabeth [California Inst. of Technology (CalTech), Pasadena, CA (United States); Dekas, Anne [California Inst. of Technology (CalTech), Pasadena, CA (United States); Hettich, Robert [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Pan, Chongle [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ellisman, Mark [University of California San Diego; Hatzenpichler, Roland [California Inst. of Technology (CalTech), Pasadena, CA (United States); Skennerton, Connor [California Inst. of Technology (CalTech), Pasadena, CA (United States); Scheller, Silvan [California Inst. of Technology (CalTech), Pasadena, CA (United States)


    The global biological CH4 cycle is largely controlled through coordinated and often intimate microbial interactions between archaea and bacteria, the majority of which are still unknown or have been only cursorily identified. Members of the methanotrophic archaea, aka ‘ANME’, are believed to play a major role in the cycling of methane in anoxic environments coupled to sulfate, nitrate, and possibly iron and manganese oxides, frequently forming diverse physical and metabolic partnerships with a range of bacteria. The thermodynamic challenges overcome by the ANME and their bacterial partners and corresponding slow rates of growth are common characteristics in anaerobic ecosystems, and, in stark contrast to most cultured microorganisms, this type of energy and resource limited microbial lifestyle is likely the norm in the environment. While we have gained an in-depth systems level understanding of fast-growing, energy-replete microorganisms, comparatively little is known about the dynamics of cell respiration, growth, protein turnover, gene expression, and energy storage in the slow-growing microbial majority. These fundamental properties, combined with the observed metabolic and symbiotic versatility of methanotrophic ANME, make these cooperative microbial systems a relevant (albeit challenging) system to study and for which to develop and optimize culture-independent methodologies, which enable a systems-level understanding of microbial interactions and metabolic networks. We used an integrative systems biology approach to study anaerobic sediment microcosms and methane-oxidizing bioreactors and expanded our understanding of the methanotrophic ANME archaea, their interactions with physically-associated bacteria, ecophysiological characteristics, and underlying genetic basis for cooperative microbial methane-oxidation linked with different terminal electron acceptors. Our approach is inherently multi-disciplinary and multi-scaled, combining transcriptional and

  18. Orbital Shapes of Asteroids in Cometary Orbits based on 0.7m Telescope Imaging (United States)

    Dueantakhu, S.; Wannawichian, S.


    The study of orbital elements of Asteroids in Cometary Orbits (ACOs) is based on images taken by a 0.7-m telescope to find positions of asteroids and calculate their orbital elements. This work focuses on variation of positions and orbital shape of an asteroid, 1667Pels, which is obtained by analyzing orbital elements and minimum orbital intersection distances. Each observation, those parameters are affected by the gravity from Jupiter on ACOs. The accuracy of single site data was calibrated by comparing the result from this work to other observations in Minor Planet Center database.

  19. Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells. (United States)

    Tsang, Jason C H; Yu, Yong; Burke, Shannon; Buettner, Florian; Wang, Cui; Kolodziejczyk, Aleksandra A; Teichmann, Sarah A; Lu, Liming; Liu, Pentao


    Hematopoietic stem cells (HSCs) are a rare cell type with the ability of long-term self-renewal and multipotency to reconstitute all blood lineages. HSCs are typically purified from the bone marrow using cell surface markers. Recent studies have identified significant cellular heterogeneities in the HSC compartment with subsets of HSCs displaying lineage bias. We previously discovered that the transcription factor Bcl11a has critical functions in the lymphoid development of the HSC compartment. In this report, we employ single-cell transcriptomic analysis to dissect the molecular heterogeneities in HSCs. We profile the transcriptomes of 180 highly purified HSCs (Bcl11a (+/+) and Bcl11a (-/-)). Detailed analysis of the RNA-seq data identifies cell cycle activity as the major source of transcriptomic variation in the HSC compartment, which allows reconstruction of HSC cell cycle progression in silico. Single-cell RNA-seq profiling of Bcl11a (-/-) HSCs reveals abnormal proliferative phenotypes. Analysis of lineage gene expression suggests that the Bcl11a (-/-) HSCs are constituted of two distinct myeloerythroid-restricted subpopulations. Remarkably, similar myeloid-restricted cells could also be detected in the wild-type HSC compartment, suggesting selective elimination of lymphoid-competent HSCs after Bcl11a deletion. These defects are experimentally validated in serial transplantation experiments where Bcl11a (-/-) HSCs are myeloerythroid-restricted and defective in self-renewal. Our study demonstrates the power of single-cell transcriptomics in dissecting cellular process and lineage heterogeneities in stem cell compartments, and further reveals the molecular and cellular defects in the Bcl11a-deficient HSC compartment.

  20. Characteristics of the two-way memory effect induced by thermomechanical cycling in Cu-Zn-Al single crystals

    International Nuclear Information System (INIS)

    Amengual, A.; Cesari, E.; Pons, J.


    Some results concerning the two-way shape memory effect induced by thermomechanical training in Cu-Zn-Al single crystals with e/a=1.48 are presented. The repetitive training procedure consists of a thermal induced transformation with the specimen submitted to a constant tensile stress and a subsequent reverse transformation without any external applied stress. The induced two-way shape memory effect is characterized by measuring the efficiency and the strength, cooling the sample under a compressive external stress. Some specimens are conveniently thermally treated in order to introduce dispersions of small γ-phase precipitates (size about 10 nm) inside the β matrix. The characteristics of the two-way memory effect shown by the material containing precipitates and the precipitate-free alloy are compared. (orig.)

  1. Hormonal, Metabolic and Cardiorespiratory Responses of Young and Adult Athletes to a Single Session of High Intensity Cycle Exercise


    Engel, Florian; Härtel, Sascha; Wagner, Matthias Oliver; Strahler, Jana; Bös, Klaus; Sperlich, Billy


    This study aimed to determine the effects of a single High Intensity Interval Training (HIIT) session on salivary cortisol (SC) levels, physiological responses and performance in trained boys and men. Twenty-three boys (11.5±0.8 years) and 25 men (29.7±4.6 years) performed HIIT (four consecutive Wingate Anaerobic Tests). SC in boys and men increased after HIIT from 5.55±3.3 nmol/l to 15.13±9.7 nmol/l (+173%) and from 7.07±4.7 nmol/l to 19.19±12.7 nmol/l (+171%), respectively (p

  2. Single and Combined Effects of Beetroot Crystals and Sodium Bicarbonate on 4-km Cycling Time Trial Performance. (United States)

    Callahan, Marcus J; Parr, Evelyn B; Hawley, John A; Burke, Louise M


    When ingested alone, beetroot juice and sodium bicarbonate are ergogenic for high-intensity exercise performance. This study sought to determine the independent and combined effects of these supplements. Eight endurance trained (VO 2 max 65 mL·kg·min -1 ) male cyclists completed four × 4-km time trials (TT) in a doubleblind Latin square design supplementing with beetroot crystals (BC) for 3 days (15 g·day -1 + 15 g 1 h before TT, containing 300 mg nitrate per 15 g), bicarbonate (Bi 0.3 g·kg -1 body mass [BM] in 5 doses every 15 min from 2.5 h before TT); BC+Bi or placebo (PLA). Subjects completed TTs on a Velotron cycle ergometer under standardized laboratory conditions. Plasma nitrite concentrations were significantly elevated only in the BC+Bi trial before the TT (1520 ± 786 nmol·L -1 ) compared with baseline (665 ± 535 nmol·L -1 , p = .02) and the Bi and PLA conditions (Bi: 593 ± 203 nmol·L -1 , p .05). Blood bicarbonate concentrations were increased in the BC+Bi and Bi trials before the TT (BC+Bi: 30.9 ± 2.8 mmol·L -1 ; Bi: 31.7 ± 1.1 mmol·L -1 ). There were no differences in mean power output (386-394 W) or the time taken to complete the TT (335.8-338.1 s) between any conditions. Under the conditions of this study, supplementation was not ergogenic for 4-km TT performance.

  3. Coexistence of spin-triplet superconductivity with magnetism within a single mechanism for orbitally degenerate correlated electrons: statistically consistent Gutzwiller approximation

    International Nuclear Information System (INIS)

    Zegrodnik, M; Spałek, J; Bünemann, J


    An orbitally degenerate two-band Hubbard model is analyzed with the inclusion of the Hund's rule-induced spin-triplet even-parity paired states and their coexistence with magnetic ordering. The so-called statistically consistent Gutzwiller approximation (SGA) has been applied to the case of a square lattice. The superconducting gaps, the magnetic moment and the free energy are analyzed as a function of the Hund's rule coupling strength and the band filling. Also, the influence of the intersite hybridization on the stability of paired phases is discussed. In order to examine the effect of correlations the results are compared with those calculated earlier within the Hartree–Fock (HF) approximation combined with the Bardeen–Cooper–Schrieffer (BCS) approach. Significant differences between the two methods used (HF + BCS versus SGA + real-space pairing) appear in the stability regions of the considered phases. Our results supplement the analysis of this canonical model used widely in the discussions of pure magnetic phases with the detailed elaboration of the stability of the spin-triplet superconducting states and the coexistent magnetic-superconducting states. At the end, we briefly discuss qualitatively the factors that need to be included for a detailed quantitative comparison with the corresponding experimental results. (paper)

  4. Not all twins are monozygotic after elective single embryo transfer: analysis of 32,600 elective single embryo transfer cycles as reported to the Society for Assisted Reproductive Technology. (United States)

    Vega, Mario; Zaghi, Sahar; Buyuk, Erkan; Jindal, Sangita


    To study the incidence and risk factors of multiple pregnancies after elective single ET. Historic cohort. Not applicable. Women single ET entered in the SART CORS database from 2010 to 2013. Not applicable. Rate of sex discordant pregnancies. Rate of same sex pregnancies and risk factors for both same sex and sex discordant pregnancies. A total of 32,600 cycles were reported to SART CORS during this time period. There were 15,143 pregnancies from which 14,888 were singletons (98.3%), 23 sex discordant (0.15%) multiple pregnancies, 226 (1.5%) sex concordant multiple pregnancies, and 6 (0.01%) pregnancies without sex information. When Weinberg's differential rule was applied, the rate of dizygotic pregnancies was calculated to be 18%. Unexplained infertility was found to be the biggest risk factor for sex discordant multiple pregnancies (adjusted odds ratio 4.33, 95% confidence interval 1.4-13.1), followed by elevated body mass index (BMI). The only risk factor found for sex concordant pregnancies was undergoing a fresh transfer (adjusted odds ratio 1.4, 95% confidence interval 1.02-1.95). Elective single ET improves, but does not completely eliminate the risk of multiple pregnancies. Patients should be counseled that there might be up to a ∼2% risk of multiple pregnancies, of which up to 18% can be dizygotic. Patients with elevated BMI and unexplained fertility may be at higher risk for sex discordant multiple pregnancies and patients undergoing fresh cycles may be at higher risk for sex concordant multiple pregnancies. Copyright © 2017 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  5. A randomized assessor-blind trial comparing highly purified hMG and recombinant FSH in a GnRH antagonist cycle with compulsory single-blastocyst transfer

    DEFF Research Database (Denmark)

    Devroey, Paul; Pellicer, Antonio; Nyboe Andersen, Anders


    OBJECTIVE: To compare the efficacy and safety of highly purified menotropin (hphMG) and recombinant FSH (rFSH) for controlled ovarian stimulation in a GnRH antagonist cycle with compulsory single-blastocyst transfer. DESIGN: Randomized, open-label, assessor-blind, parallel groups, multicenter......, noninferiority trial. SETTING: Twenty-five infertility centers in seven countries. PATIENT(S): Seven hundred forty-nine women. INTERVENTION(S): Controlled ovarian stimulation with hphMG or rFSH in a GnRH antagonist cycle with compulsory single-blastocyst transfer on day 5 in one fresh or subsequent frozen......MG versus 27% with rFSH for the per-protocol (PP) population and 29% versus 27% for the intention-to-treat (ITT) population. Noninferiority of hphMG compared to rFSH was established. Considering frozen cycles initiated within 1 year, the cumulative live birth rate for a single stimulation cycle was 40...

  6. Scaling submillimeter single-cycle transients toward megavolts per centimeter field strength via optical rectification in the organic crystal OH1. (United States)

    Ruchert, Clemens; Vicario, Carlo; Hauri, Christoph P


    We present the generation of high-power single-cycle terahertz (THz) pulses in the organic salt crystal 2-[3-(4-hydroxystyryl)-5.5-dimethylcyclohex-2-enylidene]malononitrile or OH1. Broadband THz radiation with a central frequency of 1.5 THz (λ(c)=200 μm) and high electric field strength of 440 kV/cm is produced by optical rectification driven by the signal of a powerful femtosecond optical parametric amplifier. A 1.5% pump to THz energy conversion efficiency is reported, and pulse energy stability better than 1% RMS is achieved. An approach toward the realization of higher field strength is discussed. © 2012 Optical Society of America

  7. Direct measuring of single-cycle mid-IR light bullets path length in LiF by the laser coloration method (United States)

    Chekalin, Sergey; Kompanets, Victor; Kuznetsov, Andrey; Dormidonov, Alexander; Kandidov, Valerii


    A colour-centre structure formed in a LiF crystal under filamentation of a femtosecond mid-IR laser pulse with a power slightly exceeding the critical power for self-focusing has been experimentally and theoretically investigated. A single-cycle light bullet was recorded for the first time by observation of strictly periodic oscillations for the density of the color centers induced in an isotropic LiF crystal under filamentation of a laser beam with a wavelength tuned in the range from 2600 to 3900 nm, which is due to the periodic change in the light field amplitude in the light bullet formed under filamentation under propagation in dispersive medium. The light bullet path length was not more than one millimeter.

  8. Direct measuring of single-cycle mid-IR light bullets path length in LiF by the laser coloration method

    Directory of Open Access Journals (Sweden)

    Chekalin Sergey


    Full Text Available A colour-centre structure formed in a LiF crystal under filamentation of a femtosecond mid-IR laser pulse with a power slightly exceeding the critical power for self-focusing has been experimentally and theoretically investigated. A single-cycle light bullet was recorded for the first time by observation of strictly periodic oscillations for the density of the color centers induced in an isotropic LiF crystal under filamentation of a laser beam with a wavelength tuned in the range from 2600 to 3900 nm, which is due to the periodic change in the light field amplitude in the light bullet formed under filamentation under propagation in dispersive medium. The light bullet path length was not more than one millimeter.

  9. Energy, Exergy and Economic Evaluation Comparison of Small-Scale Single and Dual Pressure Organic Rankine Cycles Integrated with Low-Grade Heat Sources

    Directory of Open Access Journals (Sweden)

    Armando Fontalvo


    Full Text Available Low-grade heat sources such as solar thermal, geothermal, exhaust gases and industrial waste heat are suitable alternatives for power generation which can be exploited by means of small-scale Organic Rankine Cycle (ORC. This paper combines thermodynamic optimization and economic analysis to assess the performance of single and dual pressure ORC operating with different organic fluids and targeting small-scale applications. Maximum power output is lower than 45 KW while the temperature of the heat source varies in the range 100–200 °C. The studied working fluids, namely R1234yf, R1234ze(E and R1234ze(Z, are selected based on environmental, safety and thermal performance criteria. Levelized Cost of Electricity (LCOE and Specific Investment Cost (SIC for two operation conditions are presented: maximum power output and maximum thermal efficiency. Results showed that R1234ze(Z achieves the highest net power output (up to 44 kW when net power output is optimized. Regenerative ORC achieves the highest performance when thermal efficiency is optimized (up to 18%. Simple ORC is the most cost-effective among the studied cycle configurations, requiring a selling price of energy of 0.3 USD/kWh to obtain a payback period of 8 years. According to SIC results, the working fluid R1234ze(Z exhibits great potential for simple ORC when compared to conventional R245fa.

  10. Retrofitted Solar Domestic Hot Water Systems for Swedish Single-Family Houses—Evaluation of a Prototype and Life-Cycle Cost Analysis

    Directory of Open Access Journals (Sweden)

    Luis Ricardo Bernardo


    Full Text Available According to recent technology road maps, system cost reductions and development of standardised plug-and-function systems are some of the most important goals for solar heating technology development. Retrofitting hot water boilers in single-family houses when installing solar collectors has the potential to significantly reduce both material and installation costs. Previous studies have investigated such retrofitting, using theoretical simulations and laboratory tests, but no actual installations were made and tested in practice. This article describes the installation, measured performance and cost effectiveness of a retrofitting solution that converts existing domestic hot water heaters to a solar domestic hot water system. The measured performance is characterised by the monthly and annual solar fractions. The cost effectiveness is evaluated by a life-cycle cost analysis, comparing the retrofitted system to a conventional solar domestic hot water system and the case without any solar heating system. Measurements showed that approximately 50% of the 5000 kWh/year of domestic hot water consumption was saved by the retrofitted system in south Sweden. Such savings are in agreement with previous estimations and are comparable to the energy savings when using a conventional solar domestic hot water system. The life-cycle cost analysis showed that, according to the assumptions and given climate, the return on investment of the retrofitted system is approximately 17 years, while a conventional system does not reach profitability during its lifetime of 25 years.

  11. Single-Cell Genome and Group-Specific dsrAB Sequencing Implicate Marine Members of the Class Dehalococcoidia (Phylum Chloroflexi) in Sulfur Cycling

    DEFF Research Database (Denmark)

    Wasmund, Kenneth; Cooper, Myriel; Schreiber, Lars


    The marine subsurface sediment biosphere is widely inhabited by bacteria affiliated with the class Dehalococcoidia (DEH), phylum Chloroflexi, and yet little is known regarding their metabolisms. In this report, genomic content from a single DEH cell (DEH-C11) with a 16S rRNA gene that was affilia......The marine subsurface sediment biosphere is widely inhabited by bacteria affiliated with the class Dehalococcoidia (DEH), phylum Chloroflexi, and yet little is known regarding their metabolisms. In this report, genomic content from a single DEH cell (DEH-C11) with a 16S rRNA gene...... that was affiliated with a diverse cluster of 16S rRNA gene sequences prevalent in marine sediments was obtained from sediments of Aarhus Bay, Denmark. The distinctive gene content of this cell suggests metabolic characteristics that differ from those of known DEH and Chloroflexi. The presence of genes encoding...... dissimilatory sulfite reductase (Dsr) suggests that DEH could respire oxidized sulfur compounds, although Chloroflexi have never been implicated in this mode of sulfur cycling. Using long-range PCR assays targeting DEH dsr loci, dsrAB genes were amplified and sequenced from various marine sediments. Many...

  12. Iterative diagonalization for orbital optimization in natural orbital functional theory. (United States)

    Piris, M; Ugalde, J M


    A challenging task in natural orbital functional theory is to find an efficient procedure for doing orbital optimization. Procedures based on diagonalization techniques have confirmed its practical value since the resulting orbitals are automatically orthogonal. In this work, a new procedure is introduced, which yields the natural orbitals by iterative diagonalization of a Hermitian matrix F. The off-diagonal elements of the latter are determined explicitly from the hermiticity of the matrix of the Lagrange multipliers. An expression for diagonal elements is absent so a generalized Fockian is undefined in the conventional sense, nevertheless, they may be determined from an aufbau principle. Thus, the diagonal elements are obtained iteratively considering as starting values those coming from a single diagonalization of the matrix of the Lagrange multipliers calculated with the Hartree-Fock orbitals after the occupation numbers have been optimized. The method has been tested on the G2/97 set of molecules for the Piris natural orbital functional. To help the convergence, we have implemented a variable scaling factor which avoids large values of the off-diagonal elements of F. The elapsed times of the computations required by the proposed procedure are compared with a full sequential quadratic programming optimization, so that the efficiency of the method presented here is demonstrated. Copyright 2009 Wiley Periodicals, Inc.


    Directory of Open Access Journals (Sweden)

    Jay Hyoun Kwon


    Full Text Available A precise kinematic orbit determination (P-KOD procedure for Low Earth Orbiter(LEO using the GPS ion-free triple differenced carrier phases is presented. Because the triple differenced observables provide only relative information, the first epoch`s positions of the orbit should be held fixed. Then, both forward and backward filtering was executed to mitigate the effect of biases of the first epoch`s position. p-KOD utilizes the precise GPS orbits and ground stations data from International GPS Service (IGS so that the only unknown parameters to be solved are positions of the satellite at each epoch. Currently, the 3-D accuracy off-KOD applied to CHAMP (CHAllenging Min-isatellite Payload shows better than 35 cm compared to the published rapid scientific orbit (RSO solution from GFZ (GeoForschungsZentrum Potsdam. The data screening for cycle slips is a particularly challenging procedure for LEO, which moves very fast in the middle of the ionospheric layer. It was found that data screening using SNR (signal to noise ratio generates best results based on the residual analysis using RSO. It is expected that much better accuracy are achievable with refined prescreening procedure and optimized geometry of the satellites and ground stations.

  14. Triple Difference Approach to Low Earth Orbiter Precision Orbit Determination (United States)

    Kwon, Jay-Hyoun; Grejner-Brzezinska, Dorota A.; Yom, Jae-Hong; Cheon, Lee-Dong


    A precise kinematic orbit determination (P-KOD) procedure for Low Earth Orbiter(LEO) using the GPS ion-free triple differenced carrier phases is presented. Because the triple differenced observables provide only relative information, the first epoch's positions of the orbit should be held fixed. Then, both forward and backward filtering was executed to mitigate the effect of biases of the first epoch's position. P-KOD utilizes the precise GPS orbits and ground stations data from International GPS Service (IGS) so that the only unknown parameters to be solved are positions of the satellite at each epoch. Currently, the 3-D accuracy of P-KOD applied to CHAMP (CHAllenging Minisatellite Payload) shows better than 35 cm compared to the published rapid scientific orbit (RSO) solution from GFZ (GeoForschungsZentrum Potsdam). The data screening for cycle slips is a particularly challenging procedure for LEO, which moves very fast in the middle of the ionospheric layer. It was found that data screening using SNR (signal to noise ratio) generates best results based on the residual analysis using RSO. It is expected that much better accuracy are achievable with refined prescreening procedure and optimized geometry of the satellites and ground stations.


    African Journals Online (AJOL)

    19 déc. 2007 ... (9) Fiorillo A. Multidisciplinary treatment of primary orbital rhabdomyosarcoma. A single institution experience. Cancer 1991;67:560-563. (10) Maurer HM. The intergroup rhabdomyosarcoma study II. Cancer. 1993;71:1904-1922. (11) Ahmed S, Shahid RK, Sison CP, Fuchs A, Mehrotra B. Orbital lymphomas:.

  16. Canard cycles with two breaking parameters


    DUMORTIER, Freddy; Roussarie, Robert


    We consider two-dimensional slow-fast systems with a layer equation exhibiting canard cycles. The canard cycles under consideration contain both a turning point and a fast orbit connecting two jump points. At both the turning point and the connecting fast orbit we suppose the presence of a parameter permitting generic breaking. Such canard cycles depend on two parameters, that we call phase parameters. We study the relaxation oscillations near the canard cycles by means of a map from the plan...


    African Journals Online (AJOL)

    was done without contrast and 3mm/5mm/10mm slices were obtained to cover the orbit, skull base and brain. The findings included a soft tissue mass arising from the orbit. The left eye ball was extra orbital. There was no defect .... love's Short Practice of Surgery. 7 Edition,. Levis London, 1997; 45-64. 2. Orbital tumor Part 1, ...

  18. Preprocessing of the GPS Raw Data for the Precision Orbit Determination by Dgps Technique

    Directory of Open Access Journals (Sweden)

    Bo-Yeon Moon


    Full Text Available This article investigates the problem of data preprocessing for the precision orbit determination (POD of low earth orbit satellite using GPS raw data. Several data preprocessing algorithms have been developed to edit the GPS data automatically such that outlier deletion, cycle slip identification and correction, and time tag error correction. The GPS data are precisely edited for the accuracy of POD. Some methods of data preprocessing are restricted to the rate of the collections of the pseudorange and carrier phase measurements. This study considers the preprocessing efficiency varied with the rate, the quality of receiver and the altitude of the satellite's orbit. We also propose the proper methods in accordance with the rate for single frequency and dual frequency receivers.

  19. Geostationary orbit capacity study (United States)

    Hansell, P. S.; Norris, P.; Walton, R.


    Factors influencing the communications satellite capacity of the geostationary orbit were analyzed to derive an interference model of the orbit environment. Comparison of the total orbit arc length required by each proposed planning method or by using different technology developments indicates that the orbit arc of most interest to Western Europe will not be saturated by the year 2000. The orbit arc occupied in the year 2000 by the satellites in the West European arc of interest can be approximately halved by using digital modulation techniques for TV program transfers which use FM at present, or by adopting an orbital planning method which assigns FM TV services to predefined orbit or spectrum segments.

  20. Radiovolumetry of the orbit

    International Nuclear Information System (INIS)

    Abujamra, S.


    The authors present a method called ''Radiovolumetry of the orbit'' that permits the evaluation of the orbital volume from anteroposterior skull X-Rays (CALDWELL 30 0 position). The research was based in the determination of the orbital volume with lead spheres, in 1010 orbits of 505 dry skulls of Anatomy Museums. After the dry skulls was X-rayed six frontal orbital diameters were made, with care to correct the radiographic amplification. PEARSON correlation coeficient test was applied between the mean orbital diameter and the orbital volume. The result was r = 0,8 with P [pt

  1. The orbital record in stratigraphy (United States)

    Fischer, Alfred G.


    Orbital signals are being discovered in pre-Pleistocene sediments. Due to their hierarchical nature these cycle patterns are complex, and the imprecision of geochronology generally makes the assignment of stratigraphic cycles to specific orbital cycles uncertain, but in sequences such as the limnic Newark Group under study by Olsen and pelagic Cretaceous sequence worked on by our Italo-American group the relative frequencies yield a definitive match to the Milankovitch hierarchy. Due to the multiple ways in which climate impinges on depositional systems, the orbital signals are recorded in a multiplicity of parameters, and affect different sedimentary facies in different ways. In platform carbonates, for example, the chief effect is via sea-level variations (possibly tied to fluctuating ice volume), resulting in cycles of emergence and submergence. In limnic systems it finds its most dramatic expression in alternations of lake and playa conditions. Biogenic pelagic oozes such as chalks and the limestones derived from them display variations in the carbonate supplied by planktonic organisms such as coccolithophores and foraminifera, and also record variations in the aeration of bottom waters. Whereas early studies of stratigraphic cyclicity relied mainly on bedding variations visible in the field, present studies are supplementing these with instrumental scans of geochemical, paleontological, and geophysical parameters which yield quantitative curves amenable to time-series analysis; such analysis is, however, limited by problems of distorted time-scales. My own work has been largely concentrated on pelagic systems. In these, the sensitivity of pelagic organisms to climatic-oceanic changes, combined with the sensitivity of botton life to changes in oxygen availability (commonly much more restricted in the Past than now) has left cyclic patterns related to orbital forcing. These systems are further attractive because (1) they tend to offer depositional continuity

  2. A vaccinia virus recombinant transcribing an alphavirus replicon and expressing alphavirus structural proteins leads to packaging of alphavirus infectious single cycle particles.

    Directory of Open Access Journals (Sweden)

    Juana M Sánchez-Puig

    Full Text Available Poxviruses and Alphaviruses constitute two promising viral vectors that have been used extensively as expression systems, or as vehicles for vaccine purposes. Poxviruses, like vaccinia virus (VV are well-established vaccine vectors having large insertion capacity, excellent stability, and ease of administration. In turn, replicons derived from Alphaviruses like Semliki Forest virus (SFV are potent protein expression and immunization vectors but stocks are difficult to produce and maintain. In an attempt to demonstrate the use of a Poxvirus as a means for the delivery of small vaccine vectors, we have constructed and characterized VV/SFV hybrid vectors. A SFV replicon cDNA was inserted in the VV genome and placed under the control of a VV early promoter. The replicon, transcribed from the VV genome as an early transcript, was functional, and thus capable of initiating its own replication and transcription. Further, we constructed a VV recombinant additionally expressing the SFV structural proteins under the control of a vaccinia synthetic early/late promoter. Infection with this recombinant produced concurrent transcription of the replicon and expression of SFV structural proteins, and led to the generation of replicon-containing SFV particles that were released to the medium and were able to infect additional cells. This combined VV/SFV system in a single virus allows the use of VV as a SFV delivery vehicle in vivo. The combination of two vectors, and the possibility of generating in vivo single-cycle, replicon containing alphavirus particles, may open new strategies in vaccine development or in the design of oncolytic viruses.

  3. A vaccinia virus recombinant transcribing an alphavirus replicon and expressing alphavirus structural proteins leads to packaging of alphavirus infectious single cycle particles. (United States)

    Sánchez-Puig, Juana M; Lorenzo, María M; Blasco, Rafael


    Poxviruses and Alphaviruses constitute two promising viral vectors that have been used extensively as expression systems, or as vehicles for vaccine purposes. Poxviruses, like vaccinia virus (VV) are well-established vaccine vectors having large insertion capacity, excellent stability, and ease of administration. In turn, replicons derived from Alphaviruses like Semliki Forest virus (SFV) are potent protein expression and immunization vectors but stocks are difficult to produce and maintain. In an attempt to demonstrate the use of a Poxvirus as a means for the delivery of small vaccine vectors, we have constructed and characterized VV/SFV hybrid vectors. A SFV replicon cDNA was inserted in the VV genome and placed under the control of a VV early promoter. The replicon, transcribed from the VV genome as an early transcript, was functional, and thus capable of initiating its own replication and transcription. Further, we constructed a VV recombinant additionally expressing the SFV structural proteins under the control of a vaccinia synthetic early/late promoter. Infection with this recombinant produced concurrent transcription of the replicon and expression of SFV structural proteins, and led to the generation of replicon-containing SFV particles that were released to the medium and were able to infect additional cells. This combined VV/SFV system in a single virus allows the use of VV as a SFV delivery vehicle in vivo. The combination of two vectors, and the possibility of generating in vivo single-cycle, replicon containing alphavirus particles, may open new strategies in vaccine development or in the design of oncolytic viruses.

  4. A Geometry-Based Cycle Slip Detection and Repair Method with Time-Differenced Carrier Phase (TDCP for a Single Frequency Global Position System (GPS + BeiDou Navigation Satellite System (BDS Receiver

    Directory of Open Access Journals (Sweden)

    Chuang Qian


    Full Text Available As the field of high-precision applications based on carriers continues to expand, the development of low-cost, small, modular receivers and their application in diverse scenarios and situations with complex data quality has increased the requirements of carrier-phase data preprocessing. A new geometry-based cycle slip detection and repair method based on Global Position System (GPS + BeiDou Navigation Satellite System (BDS is proposed. The method uses a Time-differenced Carrier Phase (TDCP model, which eliminates the Inner-System Bias (ISB between GPS and BDS, and it is conducive to the effective combination of GPS and BDS. It avoids the interference of the noise of the pseudo-range with cycle slip detection, while the cycle slips are preserved as integers. This method does not limit the receiver frequency number, and it is applicable to single-frequency data. The process is divided into two steps to detect and repair cycle slip. The first step is cycle slip detection, using the Improved Local Analysis Method (ILAM to find satellites that have cycle slips; The second step is to repair the cycle slips, including estimating the float solution of changes in ambiguities at the satellites that have cycle slips with the least squares method and the integer solution of the cycle slips by rounding. In the process of rounding, in addition to the success probability, a decimal test is carried out to validate the result. Finally, experiments with filed test data are carried out to prove the effectiveness of this method. The results show that the detectable cycle slips number with GPS + BDS is much greater than that with GPS. The method can also detect the non-integer outliers while fixing the cycle slip. The maximum decimal bias in repair is less than that with GPS. It implies that this method takes full advantages of multi-system.

  5. A Geometry-Based Cycle Slip Detection and Repair Method with Time-Differenced Carrier Phase (TDCP) for a Single Frequency Global Position System (GPS) + BeiDou Navigation Satellite System (BDS) Receiver. (United States)

    Qian, Chuang; Liu, Hui; Zhang, Ming; Shu, Bao; Xu, Longwei; Zhang, Rufei


    As the field of high-precision applications based on carriers continues to expand, the development of low-cost, small, modular receivers and their application in diverse scenarios and situations with complex data quality has increased the requirements of carrier-phase data preprocessing. A new geometry-based cycle slip detection and repair method based on Global Position System (GPS) + BeiDou Navigation Satellite System (BDS) is proposed. The method uses a Time-differenced Carrier Phase (TDCP) model, which eliminates the Inner-System Bias (ISB) between GPS and BDS, and it is conducive to the effective combination of GPS and BDS. It avoids the interference of the noise of the pseudo-range with cycle slip detection, while the cycle slips are preserved as integers. This method does not limit the receiver frequency number, and it is applicable to single-frequency data. The process is divided into two steps to detect and repair cycle slip. The first step is cycle slip detection, using the Improved Local Analysis Method (ILAM) to find satellites that have cycle slips; The second step is to repair the cycle slips, including estimating the float solution of changes in ambiguities at the satellites that have cycle slips with the least squares method and the integer solution of the cycle slips by rounding. In the process of rounding, in addition to the success probability, a decimal test is carried out to validate the result. Finally, experiments with filed test data are carried out to prove the effectiveness of this method. The results show that the detectable cycle slips number with GPS + BDS is much greater than that with GPS. The method can also detect the non-integer outliers while fixing the cycle slip. The maximum decimal bias in repair is less than that with GPS. It implies that this method takes full advantages of multi-system.

  6. Cycler orbit between Earth and Mars (United States)

    Byrnes, Dennis V.; Longuski, James M.; Aldrin, Buzz


    A periodic orbit between Earth and Mars has been discovered that, after launch, permits a space vehicle to cycle back and forth between the planets with moderate maneuvers at irregular intervals. A Space Station placed in this cycler orbit could provide a safe haven from radiation and comfortable living quarters for astronauts en route to Earth or Mars. The orbit is largely maintained by gravity assist from Earth. Numerical results from multiconic optimization software are presented for a 15-year period from 1995 through 2010.

  7. Validation of Galileo orbits using SLR with a focus on satellites launched into incorrect orbital planes (United States)

    Sośnica, Krzysztof; Prange, Lars; Kaźmierski, Kamil; Bury, Grzegorz; Drożdżewski, Mateusz; Zajdel, Radosław; Hadas, Tomasz


    The space segment of the European Global Navigation Satellite System (GNSS) Galileo consists of In-Orbit Validation (IOV) and Full Operational Capability (FOC) spacecraft. The first pair of FOC satellites was launched into an incorrect, highly eccentric orbital plane with a lower than nominal inclination angle. All Galileo satellites are equipped with satellite laser ranging (SLR) retroreflectors which allow, for example, for the assessment of the orbit quality or for the SLR-GNSS co-location in space. The number of SLR observations to Galileo satellites has been continuously increasing thanks to a series of intensive campaigns devoted to SLR tracking of GNSS satellites initiated by the International Laser Ranging Service. This paper assesses systematic effects and quality of Galileo orbits using SLR data with a main focus on Galileo satellites launched into incorrect orbits. We compare the SLR observations with respect to microwave-based Galileo orbits generated by the Center for Orbit Determination in Europe (CODE) in the framework of the International GNSS Service Multi-GNSS Experiment for the period 2014.0-2016.5. We analyze the SLR signature effect, which is characterized by the dependency of SLR residuals with respect to various incidence angles of laser beams for stations equipped with single-photon and multi-photon detectors. Surprisingly, the CODE orbit quality of satellites in the incorrect orbital planes is not worse than that of nominal FOC and IOV orbits. The RMS of SLR residuals is even lower by 5.0 and 1.5 mm for satellites in the incorrect orbital planes than for FOC and IOV satellites, respectively. The mean SLR offsets equal -44.9, -35.0, and -22.4 mm for IOV, FOC, and satellites in the incorrect orbital plane. Finally, we found that the empirical orbit models, which were originally designed for precise orbit determination of GNSS satellites in circular orbits, provide fully appropriate results also for highly eccentric orbits with variable linear

  8. Prevention of multiple pregnancies in couples with unexplained or mild male subfertility : randomised controlled trial of in vitro fertilisation with single embryo transfer or in vitro fertilisation in modified natural cycle compared with intrauterine insemination with controlled ovarian hyperstimulation

    NARCIS (Netherlands)

    Bensdorp, A. J.; Tjon-Kon-Fat, R. I.; Bossuyt, P. M. M.; Koks, C. A. M.; Oosterhuis, G. J. E.; Hoek, A.; Hompes, P. G. A.; Broekmans, F. J. M.; Verhoeve, H. R.; de Bruin, J. P.; van Golde, R.; Repping, S.; Cohlen, B. J.; Lambers, M. D. A.; van Bommel, P. F.; Slappendel, E.; Perquin, D.; Smeenk, J. M.; Pelinck, M. J.; Gianotten, J.; Hoozemans, D. A.; Maas, J. W. M.; Eijkemans, M. J. C.; van der Veen, F.; Mol, B. W. J.; van Wely, M.


    Objectives To compare the effectiveness of in vitro fertilisation with single embryo transfer or in vitro fertilisation in a modified natural cycle with that of intrauterine insemination with controlled ovarian hyperstimulation in terms of a healthy child. Design Multicentre, open label, three arm,

  9. Orbit Determination Toolbox (United States)

    Carpenter, James R.; Berry, Kevin; Gregpru. Late; Speckman, Keith; Hur-Diaz, Sun; Surka, Derek; Gaylor, Dave


    The Orbit Determination Toolbox is an orbit determination (OD) analysis tool based on MATLAB and Java that provides a flexible way to do early mission analysis. The toolbox is primarily intended for advanced mission analysis such as might be performed in concept exploration, proposal, early design phase, or rapid design center environments. The emphasis is on flexibility, but it has enough fidelity to produce credible results. Insight into all flight dynamics source code is provided. MATLAB is the primary user interface and is used for piecing together measurement and dynamic models. The Java Astrodynamics Toolbox is used as an engine for things that might be slow or inefficient in MATLAB, such as high-fidelity trajectory propagation, lunar and planetary ephemeris look-ups, precession, nutation, polar motion calculations, ephemeris file parsing, and the like. The primary analysis functions are sequential filter/smoother and batch least-squares commands that incorporate Monte-Carlo data simulation, linear covariance analysis, measurement processing, and plotting capabilities at the generic level. These functions have a user interface that is based on that of the MATLAB ODE suite. To perform a specific analysis, users write MATLAB functions that implement truth and design system models. The user provides his or her models as inputs to the filter commands. The software provides a capability to publish and subscribe to a software bus that is compliant with the NASA Goddard Mission Services Evolution Center (GMSEC) standards, to exchange data with other flight dynamics tools to simplify the flight dynamics design cycle. Using the publish and subscribe approach allows for analysts in a rapid design center environment to seamlessly incorporate changes in spacecraft and mission design into navigation analysis and vice versa.

  10. Preseptal Cellulitis, Orbital Cellulitis, Orbital Abscess

    Directory of Open Access Journals (Sweden)

    Rana Altan Yaycıoğlu


    Full Text Available Patients with orbital infections present to our clinic usually with unilateral pain, hyperemia, and edema of the eyelids. The differentiation between preseptal and orbital cellulitis is utmost important in that the second requires hospitalization. Since in orbital cellulitis, the tissues posterior to the orbital septum are involved, signs such as conjunctival chemosis, limited eye movement, decreased vision, as well as afferent pupil defect secondary to optic nerve involvement may also be observed. Prompt intravenous antibiotic treatment should be started, and surgical drainage may be performed if patient shows failure to improve in 48 hours despite optimal management. Without treatment, the clinical course may progress to subperiosteal or orbital abscess, and even to cavernous sinus thrombosis. (Turk J Ophthalmol 2012; 42: Supplement 52-6

  11. Conceptual Mean-Line Design of Single and Twin-Shaft Oxy-Fuel Gas Turbine in a Semiclosed Oxy-Fuel Combustion Combined Cycle. (United States)

    Sammak, Majed; Thorbergsson, Egill; Grönstedt, Tomas; Genrup, Magnus


    The aim of this study was to compare single- and twin-shaft oxy-fuel gas turbines in a semiclosed oxy-fuel combustion combined cycle (SCOC-CC). This paper discussed the turbomachinery preliminary mean-line design of oxy-fuel compressor and turbine. The conceptual turbine design was performed using the axial through-flow code luax-t, developed at Lund University. A tool for conceptual design of axial compressors developed at Chalmers University was used for the design of the compressor. The modeled SCOC-CC gave a net electrical efficiency of 46% and a net power of 106 MW. The production of 95% pure oxygen and the compression of CO 2 reduced the gross efficiency of the SCOC-CC by 10 and 2 percentage points, respectively. The designed oxy-fuel gas turbine had a power of 86 MW. The rotational speed of the single-shaft gas turbine was set to 5200 rpm. The designed turbine had four stages, while the compressor had 18 stages. The turbine exit Mach number was calculated to be 0.6 and the calculated value of AN 2 was 40 · 10 6 rpm 2 m 2 . The total calculated cooling mass flow was 25% of the compressor mass flow, or 47 kg/s. The relative tip Mach number of the compressor at the first rotor stage was 1.15. The rotational speed of the twin-shaft gas generator was set to 7200 rpm, while that of the power turbine was set to 4800 rpm. A twin-shaft turbine was designed with five turbine stages to maintain the exit Mach number around 0.5. The twin-shaft turbine required a lower exit Mach number to maintain reasonable diffuser performance. The compressor turbine was designed with two stages while the power turbine had three stages. The study showed that a four-stage twin-shaft turbine produced a high exit Mach number. The calculated value of AN 2 was 38 · 10 6 rpm 2 m 2 . The total calculated cooling mass flow was 23% of the compressor mass flow, or 44 kg/s. The compressor was designed with 14 stages. The preliminary design parameters of the turbine and

  12. Prevention of multiple pregnancies in couples with unexplained or mild male subfertility: randomised controlled trial of in vitro fertilisation with single embryo transfer or in vitro fertilisation in modified natural cycle compared with intrauterine insemination with controlled ovarian hyperstimulation. (United States)

    Bensdorp, A J; Tjon-Kon-Fat, R I; Bossuyt, P M M; Koks, C A M; Oosterhuis, G J E; Hoek, A; Hompes, P G A; Broekmans, F J M; Verhoeve, H R; de Bruin, J P; van Golde, R; Repping, S; Cohlen, B J; Lambers, M D A; van Bommel, P F; Slappendel, E; Perquin, D; Smeenk, J M; Pelinck, M J; Gianotten, J; Hoozemans, D A; Maas, J W M; Eijkemans, M J C; van der Veen, F; Mol, B W J; van Wely, M


    To compare the effectiveness of in vitro fertilisation with single embryo transfer or in vitro fertilisation in a modified natural cycle with that of intrauterine insemination with controlled ovarian hyperstimulation in terms of a healthy child. Multicentre, open label, three arm, parallel group, randomised controlled non-inferiority trial. 17 centres in the Netherlands. Couples seeking fertility treatment after at least 12 months of unprotected intercourse, with the female partner aged between 18 and 38 years, an unfavourable prognosis for natural conception, and a diagnosis of unexplained or mild male subfertility. Three cycles of in vitro fertilisation with single embryo transfer (plus subsequent cryocycles), six cycles of in vitro fertilisation in a modified natural cycle, or six cycles of intrauterine insemination with ovarian hyperstimulation within 12 months after randomisation. The primary outcome was birth of a healthy child resulting from a singleton pregnancy conceived within 12 months after randomisation. Secondary outcomes were live birth, clinical pregnancy, ongoing pregnancy, multiple pregnancy, time to pregnancy, complications of pregnancy, and neonatal morbidity and mortality 602 couples were randomly assigned between January 2009 and February 2012; 201 were allocated to in vitro fertilisation with single embryo transfer, 194 to in vitro fertilisation in a modified natural cycle, and 207 to intrauterine insemination with controlled ovarian hyperstimulation. Birth of a healthy child occurred in 104 (52%) couples in the in vitro fertilisation with single embryo transfer group, 83 (43%) in the in vitro fertilisation in a modified natural cycle group, and 97 (47%) in the intrauterine insemination with controlled ovarian hyperstimulation group. This corresponds to a risk, relative to intrauterine insemination with ovarian hyperstimulation, of 1.10 (95% confidence interval 0.91 to 1.34) for in vitro fertilisation with single embryo transfer and 0.91 (0

  13. The seed's protein and oil content, fatty acid composition, and growing cycle length of a single genotype of chia (Salvia hispanica L.) as affected by environmental factors. (United States)

    Ayerza, Ricardo


    As a botanical source, variability in chia seed composition could be expected between growing locations, and between years within a location, due to genotype and environment effects as well genetic x environment's interactions. The objective of the present study was to determine the location effect on the growing cycle length, and seed's protein content, lipid content, and fatty acid profiles, of a single chia genotype. Seeds of chia genotype Tzotzol grown on eight sites in five different ecosystems were tested. One site was in Argentina, in the Semi-Arid Chaco ecosystem (T(5)); one was in Bolivia, in the Sub-Humid Chaco ecosystem (T(4)); and six in Ecuador, one in the Coastal Desert (T(3)), two on the Tropical Rain Forest (T(2)), and three in the Inter-Andean Dry Valley ecosystem (T(1)). Seeds from plants grown in T(4) and in T(3) contained significantly (P seeds from the other three ecosystems. No significant (P Seeds from T(1) and T(5) ecosystems, with 33.5 and 32.2%, respectively, were the numerically highest oil content producers, but their results were only significantly (P seeds. Significant (P oils from seeds grown in different ecosystems were detected, however. Oil of seeds grown in the T(3) ecosystem had the palmitic, stearic and oleic fatty acids' highest contents. Palmitic and oleic fatty acid levels were significantly (P seeds grown in the T(1) ecosystem, and stearic when was compared to that of seeds grown in the T(5) ecosystem; omega-6 linoleic fatty acid content was significantly (P oils of seeds produced in T(1), and T(2) than in those produced in T(3), T(4), and T(5) ecosystems; omega-3 alpha-linolenic fatty acid content was significantly (P seeds produced in T(1), than in those produced in T(3), T(4), and T(5), but not in those produced in T(2).

  14. Lunar Orbiter Photo Gallery (United States)

    National Aeronautics and Space Administration — The Lunar Orbiter Photo Gallery is an extensive collection of over 2,600 high- and moderate-resolution photographs produced by all five of the Lunar Orbiter...

  15. ASC Champ Orbit Model

    DEFF Research Database (Denmark)

    Riis, Troels; Jørgensen, John Leif


    This documents describes a test of the implementation of the ASC orbit model for the Champ satellite.......This documents describes a test of the implementation of the ASC orbit model for the Champ satellite....

  16. Traumatic transconjunctival orbital emphysema.


    Stroh, E M; Finger, P T


    Orbital emphysema can be produced by trans-conjunctival migration of air from a high pressure airgun. In an industrial accident an 8 mm conjunctival laceration was produced in the superior fornix which acted as a portal of entry for air into the subconjunctival, subcutaneous, and retrobulbar spaces. Computed tomography revealed no evidence of orbital fracture and showed that traumatic orbital emphysema occurred without a broken orbital bone.

  17. Eye and orbital cavity

    International Nuclear Information System (INIS)

    Panfilova, G.V.; Koval', G.Yu.


    Radioanatomy of eyes and orbit is described. Diseases of the orbit (developmental anomalies, inflammatory diseases, lacrimal apparatus deseases, toxoplasmosis, tumors and cysts et al.), methods of foreign body localization in the eye are considered. Roentgenograms of the orbit and calculation table for foreign body localization in spherical eyes of dissimilar diameter are presented

  18. Idiopathic granulomatous orbital inflammation

    NARCIS (Netherlands)

    Mombaerts, I.; Schlingemann, R. O.; Goldschmeding, R.; Koornneef, L.


    PURPOSE: Granulomatous orbital inflammation may occur as an isolated condition of unknown origin. These idiopathic granulomatous lesions are believed to belong to the orbital pseudotumor group by some authors, whereas others consider them sarcoidosis limited to the orbit. The aim of this study is to

  19. Introducing Earth's Orbital Eccentricity (United States)

    Oostra, Benjamin


    Most students know that planetary orbits, including Earth's, are elliptical; that is Kepler's first law, and it is found in many science textbooks. But quite a few are mistaken about the details, thinking that the orbit is very eccentric, or that this effect is somehow responsible for the seasons. In fact, the Earth's orbital eccentricity is…

  20. Optimization of Initial Parameters and Fuel Afterburning Ratio in Heat-Recovery Boiler of Single- and Two-Loop Combined-Cycle Plant

    Directory of Open Access Journals (Sweden)

    B. V. Yakovlev


    Full Text Available An analysis of influence of initial parameters and fuel afterburning ratio on efficiency of sin­gle- and two-loop combined-cycle plant has been done in the paper.The paper contains fundamentals of combined-cycle plants initial parameters’ optimization and examples for the sets with gas turbines of various efficiency.

  1. Menstrual Cycle (United States)

    ... To receive General email updates Enter email Submit Menstrual Cycle The menstrual cycle is the hormonal process ... Preventing problems with your menstrual cycle View more Menstrual Cycle resources Related information Endometriosis Infertility Polycystic ovary ...

  2. Nontraumatic orbital roof encephalocele. (United States)

    Hoang, Amber; Maugans, Todd; Ngo, Thang; Ikeda, Jamie


    Intraorbital meningoencephaloceles occur most commonly as a complication of traumatic orbital roof fractures. Nontraumatic congenital orbital meningoncephaloceles are very rare, with most secondary to destructive processes affecting the orbit and primary skull defects. Treatment for intraorbital meningoencephaloceles is surgical repair, involving the excision of herniated brain parenchyma and meninges and reconstruction of the osseous defect. Most congenital lesions present in infancy with obvious globe and orbital deformities; we report an orbital meningoencephalocele in a 3-year-old girl who presented with ptosis. Copyright © 2017 American Association for Pediatric Ophthalmology and Strabismus. Published by Elsevier Inc. All rights reserved.

  3. Deadly Sunflower Orbits (United States)

    Hamilton, Douglas P.


    Solar radiation pressure is usually very effective at removing hazardous millimeter-sized debris from distant orbits around asteroidsand other small solar system bodies (Hamilton and Burns 1992). Theprimary loss mechanism, driven by the azimuthal component of radiationpressure, is eccentricity growth followed by a forced collision withthe central body. One large class of orbits, however, neatly sidestepsthis fate. Orbits oriented nearly perpendicular to the solar directioncan maintain their face-on geometry, oscillating slowly around a stableequilibrium orbit. These orbits, designated sunflower orbits, arerelated to terminator orbits studied by spacecraft mission designers(Broschart etal. 2014).Destabilization of sunflower orbits occurs only for particles smallenough that radiation pressure is some tens of percent the strength ofthe central body's direct gravity. This greatly enhanced stability,which follows from the inability of radiation incident normal to theorbit to efficiently drive eccentricities, presents a threat tospacecraft missions, as numerous dangerous projectiles are potentiallyretained in orbit. We have investigated sunflower orbits insupport of the New Horizons, Aida, and Lucy missions and find thatthese orbits are stable for hazardous particle sizes at asteroids,comets, and Kuiper belt objects of differing dimensions. Weinvestigate the sources and sinks for debris that might populate suchorbits, estimate timescales and equilibrium populations, and willreport on our findings.

  4. Closed orbit analysis for RHIC

    International Nuclear Information System (INIS)

    Milutinovic, J.; Ruggiero, A.G.


    We examine the effects of four types of errors in the RHIC dipoles and quadrupoles on the on-momentum closed orbit in the machine. We use PATRIS both to handle statistically the effects of kick-modeled errors and to check the performance of the Fermilab correcting scheme in a framework of a more realistic modeling. On the basis of the accepted rms values of the lattice errors, we conclude that in about 40% of all studied cases the lattice must be to some extent pre-corrected in the framework of the so-called ''first turn around strategy,'' in order to get a closed orbit within the aperture limitations at all and, furthermore, for approximately 2/3 of the remaining cases we find that a single pass algorithm of the Fermilab scheme is not sufficient to bring closed orbit distortions down to acceptable levels. We have modified the scheme and have allowed repeated applications of the otherwise unchanged three bump method and in doing so we have been able to correct the orbit in a satisfactory manner. 4 refs., 2 figs., 3 tabs

  5. Determination of orbitals for use in configuration interaction calculations

    International Nuclear Information System (INIS)

    Dunning, T.H. Jr.; Davidson, E.R.; Ruedenberg, K.; Hinze, J.


    For a full configuration interaction (CI) calculation the choice of orbitals is completely irrelevant, i.e., the calculated wavefunction is unaffected by an arbitrary unitary transformation of the orbitals; it depends only on the space spanned by the original basis set. For most chemical systems it is not possible to realistically carry out a full CI calculation, so that specification of the orbital set is important. Even for less-than-full CI calculations, it can be shown, however, that for certain types of calculations the wavefunction is unaffected by restricted transformations among the orbital set. For example, for CI calculations based on a single configuration plus a complete set of excitations of a given type (single, double, etc.), the calculated wavefunction is independent of transformations among the set of occupied orbitals and among the set of virtual orbitals. The wavefunction does, however, depend on transformations which mix the occupied and virtual orbitals

  6. Infertility treatment strategy involving combined freeze-all embryos and single vitrified-warmed embryo transfer during hormonal replacement cycle for in vitro fertilization of women with hypogonadotropic hypogonadism. (United States)

    Kuroda, Keiji; Ezoe, Kenji; Kato, Keiichi; Yabuuchi, Akiko; Segawa, Tomoya; Kobayashi, Tamotsu; Ochiai, Asako; Katoh, Noriko; Takeda, Satoru


    Hypogonadotropic hypogonadism (HH) is a condition caused by the deficient secretion of pituitary gonadotropins, leading to diminished ovarian function. Several studies of in vitro fertilization (IVF) in women with HH revealed acceptable clinical pregnancy outcomes but high multiple pregnancy rates after multiple fresh embryo transfer (ET). The purpose of this study was to analyze the outcomes of combined freeze-all embryos and single vitrified-warmed ET in women with HH. Of 91 infertile women with HH (basal luteinizing hormone and follicle-stimulating hormone levels <2.0 mIU/mL), we excluded patients aged ≥40 years (n = 2) and women who preferred fresh ET (n = 10). Seventy-nine women underwent 117 oocyte retrieval cycles and 135 vitrified-warmed ET during hormone replacement (HR) cycles from 2008 to 2014 at the Kato Ladies Clinic and Juntendo University Hospital. In 26 single cleavage ET cycles, the rates of clinical pregnancy and live birth were 34.6% (9/26 ET) and 26.9% (7/26 ET), respectively. Regarding the outcomes after single vitrified-warmed blastocyst transfer, clinical pregnancy and live birth rates were 65.1% (71/109 ET) and 50.5% (55/109 ET), respectively. Multiple conceptions and ovarian hyperstimulation syndrome did not occur in any of the women with HH. Our results demonstrated that IVF followed by single vitrified-warmed ET in adjusted endocrine milieu during the HR cycle is an effective fertility treatment for women with HH and decreases the incidence of complications, including multiple conceptions. © 2018 Japan Society of Obstetrics and Gynecology.

  7. Comparison of "sandwich chemo-radiotherapy" and six cycles of chemotherapy followed by adjuvant radiotherapy in patients with stage IIIC endometrial cancer: a single center experience. (United States)

    Dogan, Nasuh Utku; Yavas, Guler; Yavas, Cagdas; Ata, Ozlem; Yılmaz, Setenay Arzu; Celik, Cetin


    To compare "sandwich chemo-radiotherapy" with six cycles of chemotherapy followed by adjuvant radiotherapy with respect to tolerability and acute toxicity. Twenty-five women with surgically staged IIIC endometrial cancer were included. Treatment consisted of either three cycles of paclitaxel (175 mg/m²) and carboplatin (AUC 6) on a q21-day schedule followed by irradiation (45-50.4 Gy) or six cycles of the same chemotherapy followed by radiotherapy. Acute toxicity related to either chemotherapy or radiotherapy was evaluated. Median age was 61.5 years (range 36-83 years). Eleven patients had sandwich chemo-radiotherapy, and the other 14 patients had 6 cycles of chemotherapy followed by radiotherapy. Three out of the five patients who could not complete all the cycles in the sandwich chemo-radiotherapy group had pelvic and para-aortic radiotherapy. Acute radiotherapy related grade 1-2 gastrointestinal system (GIS) and genitourinary system (GUS) toxicities were observed in 72.8 and 63.6 % of patients, respectively, for sandwich group. Undesired treatment breaks in the course of radiotherapy were observed in six patients for sandwich chemo-radiotherapy and in one patient receiving six cycles of chemotherapy followed by radiotherapy. All the patients who had undesired treatment breaks in the sandwich chemo-radiotherapy group had pelvic and para-aortic radiotherapy. Sandwich chemo-radiotherapy seems to be more toxic particularly for patients who had pelvic and para-aortic irradiation. Therefore, it might be more convenient to delay radiotherapy after six cycles of chemotherapy for patients with the indication of pelvic para-aortic radiotherapy.

  8. Neonatal orbital abscess

    Directory of Open Access Journals (Sweden)

    Khalil M Al-Salem


    Full Text Available Orbital complications due to ethmoiditis are rare in neonates. A case of orbital abscess due to acute ethmoiditis in a 28-day-old girl is presented. A Successful outcome was achieved following antimicrobial therapy alone; spontaneous drainage of the abscess occurred from the lower lid without the need for surgery. From this case report, we intend to emphasize on eyelid retraction as a sign of neonatal orbital abscess, and to review all the available literature of similar cases.

  9. Orbital glass in HTSC

    International Nuclear Information System (INIS)

    Kusmartsev, F.V.


    The physical reasons why the orbital glass may exist in granular high-temperature superconductors and the existing experimental data appeared recently are discussed. The orbital glass is characterized by the coexistence of the orbital paramagnetic state with the superconducting state and occurs at small magnetic fields H c0 c1 . The transition in orbital glass arises at the critical field H c0 which is inversely proportional to the surface cross-area S of an average grain. In connection with theoretical predictions the possible experiments are proposed. (author). 10 refs

  10. Topology and slowing down of high energy ion orbits

    Energy Technology Data Exchange (ETDEWEB)

    Eriksson, L.G. [Commission of the European Communities, Abingdon (United Kingdom). JET Joint Undertaking; Porcelli, F. [Politecnico di Torino, Turin (Italy); Berk, H.L. [Texas Univ., Austin, TX (United States). Inst. for Fusion Studies


    An analysis of nonstandard guiding centre orbits is presented, which is relevant to MeV ions in a Tokamak. The orbit equation has been simplified from the start, allowing to present an analytic classification of the possible orbits. The topological transitions of the orbits during collisional slowing down are described. In particular, the characteristic equations reveal the existence of a single fixed point in the relevant phase plane, and the presence of a bifurcation curve corresponding to the locus of the pinch orbits. A significant particle inward pinch has been discovered. (authors). 7 figs.

  11. Congenital orbital encephalocele, orbital dystopia, and exophthalmos. (United States)

    Hwang, Kun; Kim, Han Joon


    We present here an exceedingly rare variant of a nonmidline basal encephalocele of the spheno-orbital type, and this was accompanied with orbital dystopia in a 56-year-old man. On examination, his left eye was located more inferolaterally than his right eye, and the patient said this had been this way since his birth. The protrusion of his left eye was aggravated when he is tired. His naked visual acuity was 0.7/0.3, and the ocular pressure was 14/12 mm Hg. The exophthalmometry was 10/14 to 16 mm. His eyeball motion was not restricted, yet diplopia was present in all directions. The distance from the midline to the medial canthus was 20/15 mm. The distance from the midline to the midpupillary line was 35/22 mm. The vertical dimension of the palpebral fissure was 12/9 mm. The height difference of the upper eyelid margin was 11 mm, and the height difference of the lower eyelid margin was 8 mm. Facial computed tomography and magnetic resonance imaging showed left sphenoid wing hypoplasia and herniation of the left anterior temporal pole and dura mater into the orbit, and this resulted into left exophthalmos and encephalomalacia in the left anterior temporal pole. To the best of our knowledge, our case is the second case of basal encephalocele and orbital dystopia.

  12. MRI of orbital schwannomas

    Energy Technology Data Exchange (ETDEWEB)

    Abe, T.; Kawamura, N.; Homma, H.; Sasaki, K.; Izumimaya, H.; Matsumoto, K. [Department of Neurosurgery, Showa University School of Medicine, 5-8 Hatanodai 1, Shinagawa-ku, Tokyo 142-8666 (Japan)


    The literature on MRI of orbital schwannomas is limited. The appearances in three patients with an orbital schwannoma were reviewed. A superior orbitotomy through a subfrontal craniotomy revealed a schwannoma in all cases. MRI characteristics of very low signal on T 1-weighted images and homogeneous postcontrast enhancement may be helpful for differentiating schwannomas from other intraconal masses. (orig.)

  13. Peripheral orbit model

    CERN Document Server

    Hara, Yasuo


    Peripheral orbit model, in which an incoming hadron is assumed to revolve in a peripheral orbit around a target hadron, is discussed. The non-diffractive parts of two-body reaction amplitudes of hadrons are expressed in terms of the radius, width an absorptivity of the orbit. The radius of the orbit is about 1 fm and the width of the orbit is determined by the range of the interaction between the hadrons. The model reproduces all available experimental data on differential cross-sections and polarizations of $K^{-}p\\to K^{-}p$ and $\\bar K^{\\circ}n$ reactions for all angles successfully. This contribution is not included in the proceedings since it will appear in Progress of Theoretical Physics Vol. 51 (1974) No 2. Any person interested in the subject may apply for reprints to the author.

  14. Multi-stage versus single-stage inflation and deflation cycle for alternating low pressure air mattresses to prevent pressure ulcers in hospitalised patients: a randomised-controlled clinical trial. (United States)

    Demarré, L; Beeckman, D; Vanderwee, K; Defloor, T; Grypdonck, M; Verhaeghe, S


    The duration and the amount of pressure and shear must be reduced in order to minimize the risk of pressure ulcer development. Alternating low pressure air mattresses with multi-stage inflation and deflation cycle of the air cells have been developed to relieve pressure by sequentially inflating and deflating the air cells. Evidence about the effectiveness of this type of mattress in clinical practice is lacking. This study aimed to compare the effectiveness of an alternating low pressure air mattress that has a standard single-stage inflation and deflation cycle of the air cells with an alternating low pressure air mattress with multi-stage inflation and deflation cycle of the air cells. A randomised controlled trial was performed in a convenience sample of 25 wards in five hospitals in Belgium. In total, 610 patients were included and randomly assigned to the experimental group (n=298) or the control group (n=312). In the experimental group, patients were allocated to an alternating low pressure air mattress with multi-stage inflation and deflation cycle of the air cells. In the control group, patients were allocated to an alternating low pressure air mattress with a standard single-stage inflation and deflation cycle of the air cells. The outcome was defined as cumulative pressure ulcer incidence (Grade II-IV). An intention-to-treat analysis was performed. There was no significant difference in cumulative pressure ulcer incidence (Grade II-IV) between both groups (Exp.=5.7%, Contr.=5.8%, p=0.97). When patients developed a pressure ulcer, the median time was 5.0 days in the experimental group (IQR=3.0-8.5) and 8.0 days in the control group (IQR=3.0-8.5) (Mann-Whitney U-test=113, p=0.182). The probability to remain pressure ulcer free during the observation period in this trial did not differ significantly between the experimental group and the control group (log-rank χ(2)=0.013, df=1, p=0.911). An alternating low pressure air mattress with multi-stage inflation

  15. Comparison of oxygen uptake during cycle ergometry with and without functional electrical stimulation in patients with COPD: protocol for a randomised, single-blind, placebo-controlled, cross-over trial. (United States)

    Medrinal, Clément; Prieur, Guillaume; Debeaumont, David; Robledo Quesada, Aurora; Combret, Yann; Quieffin, Jean; Contal, Olivier; Lamia, Bouchra


    Chronic obstructive pulmonary disease (COPD) has systemic repercussions that can lead to peripheral muscle dysfunction. Muscle atrophy reduces aerobic capacity, greatly limiting activities of daily living and quality of life. Pulmonary rehabilitation is the gold standard treatment for these patients, however, patients may not be able to reach sufficient training intensities for benefits to occur. Technologies such as functional electrical stimulation (FES) are currently being adapted and tested to enhance exercise training. We hypothesise that FES coupled with cycling (FES-cycling) will improve maximal uptake of oxygen (VO2) and aerobic capacity more than endurance training with placebo stimulation. A randomised, single-blind, placebo-controlled crossover trial will be carried out to evaluate the effects of FES-cycling on VO2 during endurance exercise on a cycle ergometer in patients with COPD. 25 patients with COPD will carry out two 30 min sessions at a constant load; one session with active and one with placebo FES. The primary outcome is oxygen uptake recorded with a metabolic measurement system. Secondary outcomes include ventilation equivalent for oxygen, ventilation equivalent for carbon dioxide, cardiac output, lactate values, perceived dyspnoea and perceived muscle fatigue. Approval has been granted by our Institutional Review Board (Comité de Protection des Personnes Nord-Ouest 3). The results of the trial will be presented at national and international meetings and published in peer-reviewed journals. NCT02594722.

  16. Topology of tokamak orbits

    International Nuclear Information System (INIS)

    Rome, J.A.; Peng, Y.K.M.


    Guiding center orbits in noncircular axisymmetric tokamak plasmas are studied in the constants of motion (COM) space of (v, zeta, psi/sub m/). Here, v is the particle speed, zeta is the pitch angle with respect to the parallel equilibrium current, J/sub parallels/, and psi/sub m/ is the maximum value of the poloidal flux function (increasing from the magnetic axis) along the guiding center orbit. Two D-shaped equilibria in a flux-conserving tokamak having β's of 1.3% and 7.7% are used as examples. In this space, each confined orbit corresponds to one and only one point and different types of orbits (e.g., circulating, trapped, stagnation and pinch orbits) are represented by separate regions or surfaces in the space. It is also shown that the existence of an absolute minimum B in the higher β (7.7%) equilibrium results in a dramatically different orbit topology from that of the lower β case. The differences indicate the confinement of additional high energy (v → c, within the guiding center approximation) trapped, co- and countercirculating particles whose orbit psi/sub m/ falls within the absolute B well

  17. Backtrack Orbit Search Algorithm (United States)

    Knowles, K.; Swick, R.


    A Mathematical Solution to a Mathematical Problem. With the dramatic increase in satellite-born sensor resolution traditional methods of spatially searching for orbital data have become inadequate. As data volumes increase end-users of the data have become increasingly intolerant of false positives. And, as computing power rapidly increases end-users have come to expect equally rapid search speeds. Meanwhile data archives have an interest in delivering the minimum amount of data that meets users' needs. This keeps their costs down and allows them to serve more users in a more timely manner. Many methods of spatial search for orbital data have been tried in the past and found wanting. The ever popular lat/lon bounding box on a flat Earth is highly inaccurate. Spatial search based on nominal "orbits" is somewhat more accurate at much higher implementation cost and slower performance. Spatial search of orbital data based on predict orbit models are very accurate at a much higher maintenance cost and slower performance. This poster describes the Backtrack Orbit Search Algorithm--an alternative spatial search method for orbital data. Backtrack has a degree of accuracy that rivals predict methods while being faster, less costly to implement, and less costly to maintain than other methods.

  18. Orbital cellulitis in children. (United States)

    Nageswaran, Savithri; Woods, Charles R; Benjamin, Daniel K; Givner, Laurence B; Shetty, Avinash K


    To review the epidemiology and management of orbital cellulitis in children. The medical records of children orbital cellulitis and confirmed by computed tomography scan were reviewed. A literature search for additional studies for systematic review was also conducted. Forty-one children with orbital cellulitis were identified. The mean age was 7.5 years (range, 10 months to 16 years), and 30 (73%) were male (male:female ratio = 2.7). All cases of orbital cellulitis were associated with sinusitis; ethmoid sinusitis was present in 40 (98%) patients. Proptosis and/or ophthalmoplegia was documented in 30 (73%), and 34 (83%) had subperiosteal and/or orbital abscesses. Twenty-nine (71%) had surgical drainage and 12 (29%) received antibiotic therapy only. The mean duration of hospitalization was 5.8 days. The mean duration of antibiotic therapy was 21 days. Orbital cellulitis occurs throughout childhood and in similar frequency among younger and older children. It is twice as common among males as females. Selected cases of orbital cellulitis, including many with subperiosteal abscess, can be treated successfully without surgical drainage.

  19. Harmonically excited orbital variations

    International Nuclear Information System (INIS)

    Morgan, T.


    Rephrasing the equations of motion for orbital maneuvers in terms of Lagrangian generalized coordinates instead of Newtonian rectangular cartesian coordinates can make certain harmonic terms in the orbital angular momentum vector more readily apparent. In this formulation the equations of motion adopt the form of a damped harmonic oscillator when torques are applied to the orbit in a variationally prescribed manner. The frequencies of the oscillator equation are in some ways unexpected but can nonetheless be exploited through resonant forcing functions to achieve large secular variations in the orbital elements. Two cases are discussed using a circular orbit as the control case: (1) large changes in orbital inclination achieved by harmonic excitation rather than one impulsive velocity change, and (2) periodic and secular changes to the longitude of the ascending node using both stable and unstable excitation strategies. The implications of these equations are also discussed for both artificial satellites and natural satellites. For the former, two utilitarian orbits are suggested, each exploiting a form of harmonic excitation. 5 refs

  20. A {sigma}-T diagram analysis regarding the {gamma}' inhibition in {beta} {r_reversible} {beta}' + {gamma}' cycling in CuAlNi single crystals

    Energy Technology Data Exchange (ETDEWEB)

    Gastien, R. [Dto. Ciencia y Tecnica de Materiales, Instituto de Investigaciones Cientificas y Tecnicas de las Fuerzas Armadas (CITEFA), J.B. de La Salle 4397, 1603 Villa Martelli, Buenos Aires (Argentina)]. E-mail:; Corbellani, C.E. [Dto. Ciencia y Tecnica de Materiales, Instituto de Investigaciones Cientificas y Tecnicas de las Fuerzas Armadas (CITEFA), J.B. de La Salle 4397, 1603 Villa Martelli, Buenos Aires (Argentina); Sade, M. [Centro Atomico Bariloche, Comision Nacional de Energia Atomica, 8400 S.C. de Bariloche, Rio Negro (Argentina); Lovey, F.C. [Centro Atomico Bariloche, Comision Nacional de Energia Atomica, 8400 S.C. de Bariloche, Rio Negro (Argentina)


    An effect of inhibition of the {gamma}' martensitic structure in thermal and pseudoelastic {beta} {r_reversible} {beta}' + {gamma}' cycling in CuAlNi single crystals reported previously [Gastien R, Corbellani CE, Alvarez Villar HN, Sade M, Lovey FC. Mater Sci Eng A 2003;349:191], and an experiment to determine the new thermodynamic parameters to obtain the stress-induced {gamma}' structure was performed [Gastien R, Corbellani CE, Sade M, Lovey FC. Acta Mater 2005;53:1685]. In this paper, a thermodynamic analysis of this effect using {sigma}-T diagrams is proposed, in order to obtain a proper estimation of the energy involved in the inhibition process for pseudoelastic {beta} {r_reversible} {beta}' + {gamma}' cycling.

  1. Live-cell time-lapse imaging and single-cell tracking of in vitro cultured neural stem cells - Tools for analyzing dynamics of cell cycle, migration, and lineage selection. (United States)

    Piltti, Katja M; Cummings, Brian J; Carta, Krystal; Manughian-Peter, Ayla; Worne, Colleen L; Singh, Kulbir; Ong, Danier; Maksymyuk, Yuriy; Khine, Michelle; Anderson, Aileen J


    Neural stem cell (NSC) cultures have been considered technically challenging for time-lapse analysis due to high motility, photosensitivity, and growth at confluent densities. We have tested feasibility of long-term live-cell time-lapse analysis for NSC migration and differentiation studies. Here, we describe a method to study the dynamics of cell cycle, migration, and lineage selection in cultured multipotent mouse or human NSCs using single-cell tracking during a long-term, 7-14 day live-cell time-lapse analysis. We used in-house made PDMS inserts with five microwells on a glass coverslip petri-dish to constrain NSC into the area of acquisition during long-term live-cell imaging. In parallel, we have defined image acquisition settings for single-cell tracking of cell cycle dynamics using Fucci-reporter mouse NSC for 7 days as well as lineage selection and migration using human NSC for 14 days. Overall, we show that adjustments of live-cell analysis settings can extend the time period of single-cell tracking in mouse or human NSC from 24-72 h up to 7-14 days and potentially longer. However, we emphasize that experimental use of repeated fluorescence imaging will require careful consideration of controls during acquisition and analysis. Copyright © 2017. Published by Elsevier Inc.

  2. GLONASS Orbits in Teqc: Methodology and Future Extension for Using SP3 Orbits (United States)

    Estey, L.; Wier, S.


    UNAVCO's teqc software package provides translation of a wide variety of GNSS receiver formats, metadata editing (either during translation to RINEX or on existing RINEX files), time-windowing and epoch decimation editing, and quality check (qc) analysis. Teqc is used extensively in GNSS pre-processing, and is designed to handle mixed satellite constellations, such as GPS, GLONASS, Galileo, and SBAS. The latest release of teqc adds GLONASS orbit calculations using GLONASS broadcast navigation messages, read from RINEX file format, during qc. The ephemerides for each GLONASS SV have time and orbit position in Earth-centered, Earth-fixed x, y, and z coordinates. Following Schenewerk [2003], we use trigonometric interpolation, essentially a fit of a partial sum of the Fourier series for each time-varying cartesian orbital component, allowing estimates of orbit positions at most GLONASS observation times. Tests show the interpolated GLONASS orbits made from the broadcast messages diverge from final orbits little more than the same differences using GPS orbits computed from their broadcast messages. Since GLONASS ephemerides do not use Keplerian orbital elements, GLONASS SV orbits can only be interpolated using this method for time intervals when an adequate sequence of ephemerides are available. For typical daily navigation messages collected at a single sit, when a GLONASS SV is in view less than three hours, that SV's signals are generally not used by teqc due to less precise orbit positions. Teqc quality control including SV position can now use GPS alone, GLONASS alone, or the joint solution. Future work will extend teqc to use SP3 format files, such as the IGS final orbit files, and SBAS data, which have broadcast ephemerides with elements similar to GLONASS.

  3. Solar Cycle Predictions (United States)

    Pesnell, William Dean


    Solar cycle predictions are needed to plan long-term space missions; just like weather predictions are needed to plan the launch. Fleets of satellites circle the Earth collecting many types of science data, protecting astronauts, and relaying information. All of these satellites are sensitive at some level to solar cycle effects. Predictions of drag on LEO spacecraft are one of the most important. Launching a satellite with less propellant can mean a higher orbit, but unanticipated solar activity and increased drag can make that a Pyrrhic victory as you consume the reduced propellant load more rapidly. Energetic events at the Sun can produce crippling radiation storms that endanger all assets in space. Solar cycle predictions also anticipate the shortwave emissions that cause degradation of solar panels. Testing solar dynamo theories by quantitative predictions of what will happen in 5-20 years is the next arena for solar cycle predictions. A summary and analysis of 75 predictions of the amplitude of the upcoming Solar Cycle 24 is presented. The current state of solar cycle predictions and some anticipations how those predictions could be made more accurate in the future will be discussed.

  4. Optical lattices: Orbital dance (United States)

    Lewenstein, Maciej; Liu, W. Vincent


    Emulating condensed-matter physics with ground-state atoms trapped in optical lattices has come a long way. But excite the atoms into higher orbital states, and a whole new world of exotic states appears.

  5. Neonatal orbital abscess

    Directory of Open Access Journals (Sweden)

    Pratik Y Gogri


    Full Text Available Orbital abscess generally occurs in older children but it can rarely affect infants and neonates too. We report a case of community acquired methicillin resistant staphylococcus aureus (CA-MRSA neonatal orbital abscess in a 12-day-old term female neonate with no significant past medical history or risk factor for developing the infection. The case highlights the importance of consideration of CA-MRSA as a causative agent of neonatal orbital cellulitis even in a neonate without any obvious predisposing condition. Prompt initiation of appropriate medical therapy against MRSA and surgical drainage of the abscess prevents life threatening complications of orbital cellulitis which more often tend to be fatal in neonates.

  6. Congenital orbital teratoma

    Directory of Open Access Journals (Sweden)

    Shereen Aiyub


    Full Text Available We present a case of mature congenital orbital teratoma managed with lid-sparing exenteration and dermis fat graft. This is a case report on the management of congenital orbital teratoma. A full-term baby was born in Fiji with prolapsed right globe which was surrounded by a nonpulsatile, cystic mass. Clinical and imaging features were consistent with congenital orbital teratoma. Due to limited surgical expertise, the patient was transferred to Adelaide, Australia for further management. The patient underwent a lid-sparing exenteration with frozen section control of the apical margin. A dermis fat graft from the groin was placed beneath the lid skin to provide volume. Histopathology revealed mature tissues from each of the three germ cell layers which confirmed the diagnosis of mature teratoma. We describe the successful use of demis fat graft in socket reconstruction following lid-sparing exenteration for congenital orbital teratoma.

  7. Envelopes of Cometary Orbits

    Directory of Open Access Journals (Sweden)

    Mijajlović, Ž.


    Full Text Available We discuss cometary orbits from the standpoint of Nonstandard (Leibnitz analysis, a relatively new branch of mathematics. In particular, we consider parabolic cometary paths. It appears that, in a sense, every parabola is an ellipse.

  8. Eye and orbit ultrasound (United States)

    ... the retina, or in other parts of the eye (such as melanoma ) Damaged tissue or injuries in the bony socket (orbit) that surrounds and protects the eye Foreign bodies Pulling away of the retina from ...

  9. Orbital retinoblastoma: An update (United States)

    Honavar, Santosh G; Manjandavida, Fairooz P; Reddy, Vijay Anand P


    Orbital extension is a major cause of death in children with retinoblastoma in the developing countries. Delayed detection and inappropriate management contribute to poor outcome. Conventional treatment including primary orbital exenteration or chemotherapy or radiotherapy alone result in mortality as high as 70%. The recent understanding on the role of sequential multimodal therapy with a combination of high-dose chemotherapy, followed by appropriate surgery, radiotherapy, and additional adjuvant chemotherapy has helped dramatically improve life salvage. PMID:28643706

  10. Orbital interactions in chemistry

    CERN Document Server

    Albright, Thomas A; Whangbo, Myung-Hwan


    Explains the underlying structure that unites all disciplines in chemistry Now in its second edition, this book explores organic, organometallic, inorganic, solid state, and materials chemistry, demonstrating how common molecular orbital situations arise throughout the whole chemical spectrum. The authors explore the relationships that enable readers to grasp the theory that underlies and connects traditional fields of study within chemistry, thereby providing a conceptual framework with which to think about chemical structure and reactivity problems. Orbital Interactions

  11. A single preovulatory administration of ulipristal acetate affects the decidualization process of the human endometrium during the receptive period of the menstrual cycle. (United States)

    Lira-Albarrán, Saúl; Durand, Marta; Barrera, David; Vega, Claudia; Becerra, Rocio García; Díaz, Lorenza; García-Quiroz, Janice; Rangel, Claudia; Larrea, Fernando


    In order to get further information on the effects of ulipristal acetate (UPA) upon the process of decidualization of endometrium, a functional analysis of the differentially expressed genes in endometrium (DEG) from UPA treated-versus control-cycles of normal ovulatory women was performed. A list of 1183 endometrial DEG, from a previously published study by our group, was submitted to gene ontology, gene enrichment and ingenuity pathway analyses (IPA). This functional analysis showed that decidualization was a biological process overrepresented. Gene set enrichment analysis identified LIF, PRL, IL15 and STAT3 among the most down-regulated genes within the JAK STAT canonical pathway. IPA showed that decidualization of uterus was a bio-function predicted as inhibited by UPA. The results demonstrated that this selective progesterone receptor modulator, when administered during the periovulatory phase of the menstrual cycle, may affect the molecular mechanisms leading to endometrial decidualization in response to progesterone during the period of maximum embryo receptivity. Copyright © 2018. Published by Elsevier B.V.

  12. Long-term persistence of a single Legionella pneumophila strain possessing the mip gene in a municipal shower despite repeated cycles of chlorination. (United States)

    Cooper, I R; White, J; Mahenthiralingam, E; Hanlon, G W


    The ability of Legionella pneumophila to colonise domestic water systems is a primary cause of outbreaks of Legionnaire's disease in humans. World Health Organization guidelines recommend that drinking water is chlorinated to between 0.2 and 1mg/L [Chlorine in drinking-water. Guidelines for drinking-water quality, 2nd edn. Geneva: World Health Organization; 1996], but L. pneumophila is repeatedly isolated from chlorinated water systems, indicating that this treatment is not effective at preventing colonisation. Current UK guidelines recommend a one-off treatment of 20-50mg/L of free chlorine to remove the bacteria. In this study we report on the persistence of L. pneumophila serogroup 1 in a domestic shower system despite repeated cycles of chlorination at 50mg/L for 1h exposure time, over the course of two and a half years. Persisting isolates were subjected to in-vitro phenotypic analyses and polymerase chain reaction analysis for the toxin-encoding mip gene. Random amplified polymorphic DNA typing was also performed to determine whether the isolates recovered on different occasions were the same strain. We found that seven isolates of L. pneumophila recovered over a two-and-a-half year period are the same genetically defined strain, indicating that the bacteria can persist despite repeated cycles of chlorination after each successive isolation.

  13. Sensitivity of Lambda single-particle energies to the Lambda N spin-orbit coupling and to nuclear core structure in p-shell and sd-shell hypernuclei

    Czech Academy of Sciences Publication Activity Database

    Veselý, Petr; Hiyama, E.; Hrtánková, Jaroslava; Mareš, Jiří


    Roč. 954, OCT (2016), s. 260-272 ISSN 0375-9474 R&D Projects: GA ČR(CZ) GA15-04301S Grant - others:GA MŠk(CZ) LM2010005 Institutional support: RVO:61389005 Keywords : Lambda hypernuclei * spin orbit spilitting * Lambda N interaction * mean field model Subject RIV: BE - Theoretical Physics Impact factor: 1.916, year: 2016

  14. SU-D-207A-07: The Effects of Inter-Cycle Respiratory Motion Variation On Dose Accumulation in Single Fraction MR-Guided SBRT Treatment of Renal Cell Carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Stemkens, B; Glitzner, M; Kontaxis, C; Prins, F; Crijns, SPM; Kerkmeijer, L; Lagendijk, J; Berg, CAT van den; Tijssen, RHN [Department of Radiotherapy, University Medical Center Utrecht, Utrecht (Netherlands); Denis de Senneville, B [Imaging Division, University Medical Center Utrecht, Utrecht (Netherlands); IMB, UMR 5251 CNRS/University of Bordeaux (France)


    Purpose: To assess the dose deposition in simulated single-fraction MR-Linac treatments of renal cell carcinoma, when inter-cycle respiratory motion variation is taken into account using online MRI. Methods: Three motion characterization methods, with increasing complexity, were compared to evaluate the effect of inter-cycle motion variation and drifts on the accumulated dose for an SBRT kidney MR-Linac treatment: 1) STATIC, in which static anatomy was assumed, 2) AVG-RESP, in which 4D-MRI phase-volumes were time-weighted, based on the respiratory phase and 3) PCA, in which 3D volumes were generated using a PCA-model, enabling the detection of inter-cycle variations and drifts. An experimental ITV-based kidney treatment was simulated in a 1.5T magnetic field on three volunteer datasets. For each volunteer a retrospectively sorted 4D-MRI (ten respiratory phases) and fast 2D cine-MR images (temporal resolution = 476ms) were acquired to simulate MR-imaging during radiation. For each method, the high spatio-temporal resolution 3D volumes were non-rigidly registered to obtain deformation vector fields (DVFs). Using the DVFs, pseudo-CTs (generated from the 4D-MRI) were deformed and the dose was accumulated for the entire treatment. The accuracies of all methods were independently determined using an additional, orthogonal 2D-MRI slice. Results: Motion was most accurately estimated using the PCA method, which correctly estimated drifts and inter-cycle variations (RMSE=3.2, 2.2, 1.1mm on average for STATIC, AVG-RESP and PCA, compared to the 2DMRI slice). Dose-volume parameters on the ITV showed moderate changes (D99=35.2, 32.5, 33.8Gy for STATIC, AVG-RESP and PCA). AVG-RESP showed distinct hot/cold spots outside the ITV margin, which were more distributed for the PCA scenario, since inter-cycle variations were not modeled by the AVG-RESP method. Conclusion: Dose differences were observed when inter-cycle variations were taken into account. The increased inter-cycle

  15. Theory of Orbital Magnetization in Solids (United States)

    Thonhauser, T.

    In this review article, we survey the relatively new theory of orbital magnetization in solids — often referred to as the "modern theory of orbital magnetization" — and its applications. Surprisingly, while the calculation of the orbital magnetization in finite systems such as atoms and molecules is straight forward, in extended systems or solids it has long eluded calculations owing to the fact that the position operator is ill-defined in such a context. Approaches that overcome this problem were first developed in 2005 and in the first part of this review we present the main ideas reaching from a Wannier function approach to semi-classical and finite-temperature formalisms. In the second part, we describe practical aspects of calculating the orbital magnetization, such as taking k-space derivatives, a formalism for pseudopotentials, a single k-point derivation, a Wannier interpolation scheme, and DFT specific aspects. We then show results of recent calculations on Fe, Co, and Ni. In the last part of this review, we focus on direct applications of the orbital magnetization. In particular, we will review how properties such as the nuclear magnetic resonance shielding tensor and the electron paramagnetic resonance g-tensor can be elegantly calculated in terms of a derivative of the orbital magnetization.

  16. The kinetics of blood lactate in boys during and following a single and repeated all-out sprints of cycling are different than in men. (United States)

    Engel, Florian Azad; Sperlich, Billy; Stockinger, Christian; Härtel, Sascha; Bös, Klaus; Holmberg, Hans-Christer


    This study characterized the impact of high-intensity interval training on the kinetics of blood lactate and performance in trained boys and men. Twenty-one boys (11.4 ± 0.8 years) and 19 men (29.4 ± 5.0 years) performed a set of four 30-s sprints with 2-min of rest and a single 30-s sprint on 2 separate occasions (randomized order) with assessment of performance. Blood lactate was assayed after each sprint and during 30 min of recovery from both tests. The individual time-curves of blood lactate concentration were fitted to the biexponential function as follows: [Formula: see text], where the velocity parameters γ1 and γ2 reflect the capacity to release lactate from the previously active muscle into the blood and to subsequently eliminate lactate from the organism, respectively. In both tests, peak blood lactate concentration was significantly lower in the boys (four 30-s sprints: 12.2 ± 3.6 mmol·L(-1); single 30-s sprint: 8.7 ± 1.8 mmol·L(-1)) than men (four 30-s sprints: 16.1 ± 3.3 mmol·L(-1); single 30-s sprint: 11.5 ± 2.1; p boys exhibited faster γ1 (1.4531 ± 0.65 min; p boys (9.2% ± 13.9%) than men (19.2% ± 11.5%; p = 0.01). In the present study boys, when compared with men, exhibited lower Peak blood lactate concentration; less pronounced decline in performance during the sprints concomitantly with more rapid release and elimination during the single 30-s sprint; and faster elimination of lactate following the four 30-s sprints.

  17. Kozai Cycles and Tidal Friction

    Energy Technology Data Exchange (ETDEWEB)

    L, K; P.P., E


    Several studies in the last three years indicate that close binaries, i.e. those with periods of {approx}< 3 d, are very commonly found to have a third body in attendance. We argue that this proves that the third body is necessary in order to make the inner period so short, and further argue that the only reasonable explanation is that the third body causes shrinkage of the inner period, from perhaps a week or more to the current short period, by means of the combination of Kozai cycles and tidal friction (KCTF). In addition, once KCTF has produced a rather close binary, magnetic braking also combined with tidal friction (MBTF) can decrease the inner orbit further, to the formation of a contact binary or even a merged single star. Some of the products of KCTF that have been suggested, either by others or by us, are W UMa binaries, Blue Stragglers, X-ray active BY Dra stars, and short-period Algols. We also argue that some components of wide binaries are actually merged remnants of former close inner pairs. This may include such objects as rapidly rotating dwarfs (AB Dor, BO Mic) and some (but not all) Be stars.

  18. Orbital Order in Two-Orbital Hubbard Model (United States)

    Honkawa, Kojiro; Onari, Seiichiro


    In strongly correlated multiorbital systems, various ordered phases appear. In particular, the orbital order in iron-based superconductors attracts much attention since it is considered to be the origin of the nematic state. To clarify the essential conditions for realizing orbital orders, we study the simple two-orbital (dxz,dyz) Hubbard model. We find that the orbital order, which corresponds to the nematic order, appears due to the vertex corrections even in the two-orbital model. Thus, the dxy orbital is not essential to realize the nematic orbital order. The obtained orbital order is determined by the orbital dependence and the topology of Fermi surfaces. We also find that another type of orbital order, which is rotated 45°, appears in a heavily hole-doped case.

  19. Ultrathin single-crystalline TiO2 nanosheets anchored on graphene to be hybrid network for high-rate and long cycle-life sodium battery electrode application (United States)

    Shoaib, Anwer; Huang, Yongxin; Liu, Jia; Liu, Jiajia; Xu, Meng; Wang, Ziheng; Chen, Renjie; Zhang, Jiatao; Wu, Feng


    In view of the growing concern about energy management issues, sodium ion batteries (SIBs) as cheap and environmentally friendly devices have increasingly received wide research attentions. The high current rate and long cycle-life of SIBs are considered as two key parameters determining its potential for practical applications. In this work, the rigid single-crystalline anatase TiO2 nanosheets (NSs) with a thickness of ∼4 nm has been firstly prepared, based on which a stable nanostructured network consisting of ultrathin anatase TiO2 NSs homogeneously anchored on graphene through chemical bonding (TiO2 NSs-G) has fabricated by hydrothermal process and subsequent calcination treatment. The morphology, crystallization, chemical compositions and the intimate maximum contact between TiO2 NSs and graphene are confirmed by TEM, SEM, XRD, XPS and Raman characterizations. The results of electrochemical performance tests indicated that the TiO2 NSs-G hybrid network could be consider as a promising anode material for SIBs, in assessment of its remarkably high current rate and long cycle-life aside from the improved specific capacity, rate capability and cycle stability.

  20. Spin and orbital moments in actinide compounds

    DEFF Research Database (Denmark)

    Lebech, B.; Wulff, M.; Lander, G.H.


    experiments designed to determine the magnetic moments at the actinide and transition-metal sublattice sites in compounds such as UFe2, NpCo2, and PuFe2 and to separate the spin and orbital components at the actinide sites. The results show, indeed, that the ratio of the orbital to spin moment is reduced......The extended spatial distribution of both the transition-metal 3d electrons and the actinide 5f electrons results in a strong interaction between these electron states when the relevant elements are alloyed. A particular interesting feature of this hybridization, which is predicted by single...

  1. The Strutjet Rocket Based Combined Cycle Engine (United States)

    Siebenhaar, A.; Bulman, M. J.; Bonnar, D. K.


    The multi stage chemical rocket has been established over many years as the propulsion System for space transportation vehicles, while, at the same time, there is increasing concern about its continued affordability and rather involved reusability. Two broad approaches to addressing this overall launch cost problem consist in one, the further development of the rocket motor, and two, the use of airbreathing propulsion to the maximum extent possible as a complement to the limited use of a conventional rocket. In both cases, a single-stage-to-orbit (SSTO) vehicle is considered a desirable goal. However, neither the "all-rocket" nor the "all-airbreathing" approach seems realizable and workable in practice without appreciable advances in materials and manufacturing. An affordable system must be reusable with minimal refurbishing on-ground, and large mean time between overhauls, and thus with high margins in design. It has been suggested that one may use different engine cycles, some rocket and others airbreathing, in a combination over a flight trajectory, but this approach does not lead to a converged solution with thrust-to-mass, specific impulse, and other performance and operational characteristics that can be obtained in the different engines. The reason is this type of engine is simply a combination of different engines with no commonality of gas flowpath or components, and therefore tends to have the deficiencies of each of the combined engines. A further development in this approach is a truly combined cycle that incorporates a series of cycles for different modes of propulsion along a flight path with multiple use of a set of components and an essentially single gas flowpath through the engine. This integrated approach is based on realizing the benefits of both a rocket engine and airbreathing engine in various combinations by a systematic functional integration of components in an engine class usually referred to as a rocket-based combined cycle (RBCC) engine

  2. Tailoring spin-orbit torque in diluted magnetic semiconductors

    KAUST Repository

    Li, Hang


    We study the spin orbit torque arising from an intrinsic linear Dresselhaus spin-orbit coupling in a single layer III-V diluted magnetic semiconductor. We investigate the transport properties and spin torque using the linear response theory, and we report here: (1) a strong correlation exists between the angular dependence of the torque and the anisotropy of the Fermi surface; (2) the spin orbit torque depends nonlinearly on the exchange coupling. Our findings suggest the possibility to tailor the spin orbit torque magnitude and angular dependence by structural design.

  3. Extended duration orbiter (EDO) insignia (United States)


    Extended duration orbiter (EDO) insignia incorporates a space shuttle orbiter with payload bay doors (PLBDs) open and a spacelab module inside. Trailing the orbiter are the initials EDO. The EDO-modified Columbia, Orbiter Vehicle (OV) 102, will be flown for the first EDO mission, STS-50.

  4. Elliptical Orbit Performance Computer Program (United States)

    Myler, T.


    Elliptical Orbit Performance (ELOPE) computer program for analyzing orbital performance of space boosters uses orbit insertion data obtained from trajectory simulation to generate parametric data on apogee and perigee altitudes as function of payload data. Data used to generate presentation plots that display elliptical orbit performance capability of space booster.

  5. Rolling cycle amplification based single-color quantum dots–ruthenium complex assembling dyads for homogeneous and highly selective detection of DNA

    Energy Technology Data Exchange (ETDEWEB)

    Su, Chen; Liu, Yufei; Ye, Tai; Xiang, Xia; Ji, Xinghu; He, Zhike, E-mail:


    Graphical abstract: A universal, label-free, homogeneous, highly sensitive, and selective fluorescent biosensor for DNA detection is developed by using rolling-circle amplification (RCA) based single-color quantum dots–ruthenium complex (QDs–Ru) assembling dyads. - Highlights: • The single-color QDs–Ru assembling dyads were applied in homogeneous DNA assay. • This biosensor exhibited high selectivity against base mismatched sequences. • This biosensor could be severed as universal platform for the detection of ssDNA. • This sensor could be used to detect the target in human serum samples. • This DNA sensor had a good selectivity under the interference of other dsDNA. - Abstract: In this work, a new, label-free, homogeneous, highly sensitive, and selective fluorescent biosensor for DNA detection is developed by using rolling-circle amplification (RCA) based single-color quantum dots–ruthenium complex (QDs–Ru) assembling dyads. This strategy includes three steps: (1) the target DNA initiates RCA reaction and generates linear RCA products; (2) the complementary DNA hybridizes with the RCA products to form long double-strand DNA (dsDNA); (3) [Ru(phen){sub 2}(dppx)]{sup 2+} (dppx = 7,8-dimethyldipyrido [3,2-a:2′,3′-c] phenanthroline) intercalates into the long dsDNA with strong fluorescence emission. Due to its strong binding propensity with the long dsDNA, [Ru(phen){sub 2}(dppx)]{sup 2+} is removed from the surface of the QDs, resulting in restoring the fluorescence of the QDs, which has been quenched by [Ru(phen){sub 2}(dppx)]{sup 2+} through a photoinduced electron transfer process and is overlaid with the fluorescence of dsDNA bonded Ru(II) polypyridyl complex (Ru-dsDNA). Thus, high fluorescence intensity is observed, and is related to the concentration of target. This sensor exhibits not only high sensitivity for hepatitis B virus (HBV) ssDNA with a low detection limit (0.5 pM), but also excellent selectivity in the complex matrix. Moreover

  6. Exact relations between homoclinic and periodic orbit actions in chaotic systems (United States)

    Li, Jizhou; Tomsovic, Steven


    Homoclinic and unstable periodic orbits in chaotic systems play central roles in various semiclassical sum rules. The interferences between terms are governed by the action functions and Maslov indices. In this article, we identify geometric relations between homoclinic and unstable periodic orbits, and derive exact formulas expressing the periodic orbit classical actions in terms of corresponding homoclinic orbit actions plus certain phase space areas. The exact relations provide a basis for approximations of the periodic orbit actions as action differences between homoclinic orbits with well-estimated errors. This enables an explicit study of relations between periodic orbits, which results in an analytic expression for the action differences between long periodic orbits and their shadowing decomposed orbits in the cycle expansion.

  7. Orbital mantle cell lymphoma presenting as myasthenia gravis. (United States)

    Karlin, Justin; Peck, Travis; Prenshaw, Karyn; Portell, Craig A; Kirzhner, Maria


    A 69-year-old man, previously treated with pyridostigmine for myasthenia gravis (manifesting as ptosis and diplopia) was evaluated for several concomitant bilateral anterior orbital masses. Imaging revealed 3 discrete, solid masses within and around the orbits. An incisional biopsy demonstrated atypical lymphocytes positive for CD20 and Cyclin-D1, consistent with mantle cell lymphoma. The patient received induction chemotherapy with a rituximab-based regimen. He experienced resolution of his diplopia and ptosis after one cycle of chemotherapy and achieved complete remission of the orbital masses and myasthenia symptoms after 6 cycles. Myasthenia gravis is most commonly associated with thymoma, but may also be observed with other malignancies. Recognition that orbital lymphoma may coexist with myasthenia gravis will help in expediting the diagnosis of future cases and in guiding treatment decisions.

  8. Orbitals from local RDMFT: Are they Kohn-Sham or natural orbitals?

    International Nuclear Information System (INIS)

    Theophilou, Iris; Helbig, Nicole; Lathiotakis, Nektarios N.; Gidopoulos, Nikitas I.; Rubio, Angel


    Recently, an approximate theoretical framework was introduced, called local reduced density matrix functional theory (local-RDMFT), where functionals of the one-body reduced density matrix (1-RDM) are minimized under the additional condition that the optimal orbitals satisfy a single electron Schrödinger equation with a local potential. In the present work, we focus on the character of these optimal orbitals. In particular, we compare orbitals obtained by local-RDMFT with those obtained with the full minimization (without the extra condition) by contrasting them against the exact NOs and orbitals from a density functional calculation using the local density approximation (LDA). We find that the orbitals from local-RMDFT are very close to LDA orbitals, contrary to those of the full minimization that resemble the exact NOs. Since local RDMFT preserves the good quality of the description of strong static correlation, this finding opens the way to a mixed density/density matrix scheme, where Kohn-Sham orbitals obtain fractional occupations from a minimization of the occupation numbers using 1-RDM functionals. This will allow for a description of strong correlation at a cost only minimally higher than a density functional calculation

  9. Precise orbits of the Lunar Reconnaissance Orbiter from radiometric tracking data (United States)

    Löcher, Anno; Kusche, Jürgen


    Since 2009, the Lunar Reconnaissance Orbiter (LRO) acquires images and altimetric profiles of the lunar surface. Assembling these data to maps and terrain models requires the precise knowledge of the spacecraft trajectory. In this contribution, we present 5 years of LRO orbits from radiometric data processed with a software tailored to this mission. The presented orbits are the first independent validation of the LRO science orbits from NASA and are available for public use. A key feature of our processing is the elaborate treatment of model and observation errors by empirical parameters and an adaptive data weighting by variance component estimation. The quality of the resulting orbits is assessed by analyzing overlapping arcs. For our solution based on arcs of 2.5 days, such analysis yields a mean error of 2.81 m in total position and 0.11 m in radial direction. It is shown that this result greatly benefits from the adaptive data weighting, reducing the error by 2.54 and 0.13 m, respectively. Unfortunately, the precision achieved varies strongly, dependent on the view onto the orbital ellipse which changes with the lunar cycle. To mitigate this dependency, the arc length was extended in steps up to 10.5 days, leading in the best case to a further improvement of 0.80 m.

  10. Orbital lymphoid tumors

    International Nuclear Information System (INIS)

    Matsumoto, Hiroko; Ueno, Hisayuki


    We examined 13 cases of orbital lymphoid tumors (OLT) and 1 of orbital hemangioma (OH), using dynamic MRI, to determine the biological behavior of the tumors before surgery. We measured time-dependent changes in the contrast enhancement of tumors and described time intensity curves (TIC), dividing the cases into 3 architectural types: completes septum (CS), incomplete septum (IS), and diffuse types. The TICs of reactive lymphoid hyperplasia (RLH, 2 cases) of CS type and idiopathic orbital inflamation (1), RLH (5) of IS type, atypical lymphoid hyperplasia (4), and malignant lymphoma (1) and OH (1) showed rapid increase with low peak and gradual decrease, rapid increase with high peak and gradual decrease, rapid increase and plateau, and gradual increase type, respectively. In order words, OLT showed various TIC, roughly correlating with pathological findings. These results indicate that dynamic MRI may be useful in the preoperative clinical diagnosis of OLT. (author)

  11. [Secondary orbital lymphoma]. (United States)

    Basanta, I; Sevillano, C; Álvarez, M D


    A case is presented of an 85 year-old Caucasian female with lymphoma that recurred in the orbit (secondary ocular adnexal lymphoma). The orbital tumour was a diffuse large B-cell lymphoma according to the REAL classification (Revised European-American Lymphoma Classification). Orbital lymphomas are predominantly B-cell proliferations of a variety of histological types, and most are low-grade tumours. Patients are usually middle-aged or elderly, and it is slightly more common in women. A palpable mass, proptosis and blepharoptosis are the most common signs of presentation. Copyright © 2011 Sociedad Española de Oftalmología. Published by Elsevier España, S.L.U. All rights reserved.

  12. Large orbit neoclassical transport

    International Nuclear Information System (INIS)

    Lin, Z.; Tang, W.M.; Lee, W.W.


    Neoclassical transport in the presence of large ion orbits is investigated. The study is motivated by the recent experimental results that ion thermal transport levels in enhanced confinement tokamak plasmas fall below the open-quotes irreducible minimum levelclose quotes predicted by standard neoclassical theory. This apparent contradiction is resolved in the present analysis by relaxing the basic neoclassical assumption that the ions orbital excursions are much smaller than the local toroidal minor radius and the equilibrium scale lengths of the system. Analytical and simulation results are in agreement with trends from experiments. The development of a general formalism for neoclassical transport theory with finite orbit width is also discussed. copyright 1997 American Institute of Physics

  13. Preseptal Cellulitis Or Orbital Cellulitis? (United States)

    Lim, L T; Miller, D; Ah-Kee, E Y; Ferguson, A


    Preseptal cellulitis and orbital cellulitis can both present with increasing swelling, tenderness and redness around the eye, but their management differs. Preseptal cellulitis is more common and much less aggressive than orbital cellulitis. In contrast, orbital cellulitis is a medical emergency requiring urgent management. In this article, we provide a systematic approach to distinguish between preseptal cellulitis and orbital cellulitis at presentation, as the distinction between the two entities and the prompt recognition of orbital cellulitis can be potentially life-saving.

  14. Giant cell reparative granuloma of the orbit associated with cherubism. (United States)

    Font, Ramon L; Blanco, Gonzalo; Soparkar, Charles N; Patrinely, James R; Ostrowski, Mary L


    To report a case of cherubism with extensive, bilateral orbital involvement occurring in a 27-year-old woman who had the diagnosis established at the age of 4 years. Single interventional case report. Ophthalmologic examination and computed tomography were performed. The patient underwent multiple surgical excisions using a bicoronal and transorbital approach. The excised orbital tissues were studied histopathologically. Computed tomography showed bilateral inferior lateral masses involving the orbital floors and producing marked superior displacement of the orbital contents. The intrinsic expansile bone lesions involved the inferior and lateral orbital walls with apical compression of the optic nerves. Histopathologic examination of the masses revealed scattered giant cells in a fibroblastic stroma containing small vascular channels. The lesion was interpreted as giant cell reparative granuloma. Giant cell reparative granuloma is an uncommon bone lesion that might involve the orbit. Cherubism should be included in the differential diagnosis of lesions that show the histopathologic features of giant cell reparative granuloma.

  15. Transfer and capture into distant retrograde orbits (United States)

    Scott, Christopher J.

    collision orbits within the highly chaotic region commonly recognized as a saddle point on the energy manifold. The pragmatic techniques derived from this analysis solve a number of complications apparent in the literature. Notably a reliable methodology for the construction of an arbitrary number of transfer orbits circumvents the requirement of computing specialized periodic orbits or extensive numerical sampling of the phase space. The procedure provides a complete description of the design space accessing a wide range of distant retrograde orbits sizes, insertion points, and parking orbit altitudes in an automated manner. The transfers are studied in a similar fashion to periodic orbits unveiling the intimate relationship among design parameters and phase space structure. An arbitrary number of Earth return periodic orbits can be generated as a by-product. These orbits may be useful for spacecraft that must make a number of passes near the second primary without a reduction in energy. Further analysis of the lobe dynamics and a modification of the transfers to the center of the stable region yields sets of single impulse transfers to sticky distant retrograde orbits. It is shown that the evolution of the phase space structures with energy corresponds to the variation of capture time and target size. Capture phenomenon is related to the stability characteristics of the unstable periodic orbit and the geometry of the corresponding homoclinic tangle at various energies. Future spacecraft with little or no propulsive means may take advantage of these natural trajectories for operations in the region. Temporary capture along a sticky orbit may come before incremental stabilization of the spacecraft by way of a series of small impulsive or a low continuous thrust maneuvers. The requirements of small stabilization maneuver are calculated and compared to a direct transfer to the center of stable region. This mission design may be desirable as any failure in the classic set of

  16. Stable orbits for lunar landing assistance (United States)

    Condoleo, Ennio; Cinelli, Marco; Ortore, Emiliano; Circi, Christian


    To improve lunar landing performances in terms of mission costs, trajectory determination and visibility the use of a single probe located over an assistance orbit around the Moon has been taken into consideration. To this end, the properties of two quasi-circular orbits characterised by a stable behaviour of semi-major axis, eccentricity and inclination have been investigated. The analysis has demonstrated the possibility of using an assistance probe, located over one of these orbits, as a relay satellite between lander and Earth, even in the case of landings on the far side of the Moon. A comparison about the accuracy in retrieving the lander's state with respect to the use of a probe located in the Lagrangian point L2 of the Earth-Moon system has also been carried out.

  17. Spin-orbit mediated control of spin qubits

    DEFF Research Database (Denmark)

    Flindt, Christian; Sørensen, A.S; Flensberg, Karsten


    We propose to use the spin-orbit interaction as a means to control electron spins in quantum dots, enabling both single-qubit and two-qubit operations. Very fast single-qubit operations may be achieved by temporarily displacing the electrons. For two-qubit operations the coupling mechanism is based...... on a combination of the spin-orbit coupling and the mutual long-ranged Coulomb interaction. Compared to existing schemes using the exchange coupling, the spin-orbit induced coupling is less sensitive to random electrical fluctuations in the electrodes defining the quantum dots....

  18. Preface: The Lunar Reconnaissance Orbiter (United States)

    Keller, John W.; Gaddis, L.; Petro, N.; Aharonson, O.


    When the call for papers for a special issue of Icarus devoted to analysis of data from the Lunar Reconnaissance Orbiter mission was announced in March 2015 we envisioned a single issue with only a possibility of a second. We certainly were gratified by the response from within and outside the LRO instrument teams such that we were compelled to publish this the third and final volume. It is a testament to the Moon as object that enhances our understanding of the history of the Earth-Moon system, the Solar System as a whole, and geologic processes that take place on the Moon and other atmosphere-less bodies. Many of the publications included lead authors outside the LRO team of co-investigators, using data from multiple instruments from LRO and other recent missions.

  19. Myxoma of the orbit.

    Directory of Open Access Journals (Sweden)

    Rambhatla Saptagirish


    Full Text Available Myxomas are rare, benign neoplasms of mesenchymal origin that usually develop in soft tissues. As the clinical manifestations are non-specific, it is difficult to diagnose the tumour without biopsy and histopathological examination. We report a case of orbital myxoma with histopathological correlation.

  20. The Lunar orbit paradox

    Directory of Open Access Journals (Sweden)

    Tomić Aleksandar S.


    Full Text Available Newton's formula for gravity force gives greather force intensity for atraction of the Moon by the Sun than atraction by the Earth. However, central body in lunar (primary orbit is the Earth. So appeared paradox which were ignored from competent specialist, because the most important problem, determination of lunar orbit, was inmediately solved sufficiently by mathematical ingeniosity - introducing the Sun as dominant body in the three body system by Delaunay, 1860. On this way the lunar orbit paradox were not canceled. Vujičić made a owerview of principles of mechanics in year 1998, in critical consideration. As an example for application of corrected procedure he was obtained gravity law in some different form, which gave possibility to cancel paradox of lunar orbit. The formula of Vujičić, with our small adaptation, content two type of acceleration - related to inertial mass and related to gravity mass. So appears carried information on the origin of the Moon, and paradox cancels.

  1. 11. Deadly Orbital Mucormycosis

    African Journals Online (AJOL)


    medial recti muscles. The conclusion reached was orbital pseudo-tumour RE with a differential diagnosis of lymphoma. The CT Scan film below shows the retro-bulbar tumour described in the report. Other investigations done were fasting Blood Sugar which was ... thrombosis and death of surrounding tissue by loss. 6.

  2. Meteoroid Orbits from Observations (United States)

    Campbell-Brown, Margaret


    Millions of orbits of meteoroids have been measured over the last few decades, and they comprise the largest sample of orbits of solar system bodies which exists. The orbits of these objects can shed light on the distribution and evolution of comets and asteroids in near-Earth space (e.g. Neslusan et al. 2016). If orbits can be measured at sufficiently high resolution, individual meteoroids can be traced back to their parent bodies and, in principle, even to their ejection time (Rudawska et al. 2012). Orbits can be measured with multi-station optical observations or with radar observations.The most fundamental measured quantities are the speed of the meteor and the two angles of the radiant, or point in the sky from which the meteor appears to come. There are many methods used to determine these from observations, but not all produce the most accurate results (Egal et al. 2017). These three measured quantities, along with the time and location of the observation, are sufficient to obtain an orbit (see, e.g., Clark & Wiegert 2011), but the measurements must be corrected for the deceleration of the meteoroid in the atmosphere before it was detected, the rotation of the Earth, and the gravitational attraction of the Earth (including higher order moments if great precision is necessary).Once meteor orbits have been determined, studies of the age and origin of meteor showers (Bruzzone et al., 2015), the parent bodies of sporadic sources (Pokorny et al. 2014), and the dynamics of the meteoroid complex as a whole can be constrained.Bruzzone, J. S., Brown, P., Weryk, R., Campbell-Brown, M., 2015. MNRAS 446, 1625.Clark, D., Wiegert, P., 2011. M&PS 46, 1217.Egal, A., Gural, P., Vaubaillon, J., Colas, F., Thuillot, W., 2017. Icarus 294, 43.Neslusan, L., Vaubaillon, J., Hajdukova, M., 2016. A&A 589, id.A100.Pokorny, P., Vokrouhlicky, D., Nesvorny, D., Campbell-Brown, M., Brown, P., 2014. ApJ 789, id.25.Rudawska, R., Vaubaillon, J., Atreya, P., 2012. A&A 541, id.A2

  3. Superfluid thermodynamic cycle refrigerator (United States)

    Swift, Gregory W.; Kotsubo, Vincent Y.


    A cryogenic refrigerator cools a heat source by cyclically concentrating and diluting the amount of .sup.3 He in a single phase .sup.3 He-.sup.4 He solution. The .sup.3 He in superfluid .sup.4 He acts in a manner of an ideal gas in a vacuum. Thus, refrigeration is obtained using any conventional thermal cycle, but preferably a Stirling or Carnot cycle. A single phase solution of liquid .sup.3 He at an initial concentration in superfluid .sup.4 He is contained in a first variable volume connected to a second variable volume through a superleak device that enables free passage of .sup.4 He while restricting passage of .sup.3 He. The .sup.3 He is compressed (concentrated) and expanded (diluted) in a phased manner to carry out the selected thermal cycle to remove heat from the heat load for cooling below 1 K.

  4. Local orbitals by minimizing powers of the orbital variance

    DEFF Research Database (Denmark)

    Jansik, Branislav; Høst, Stinne; Kristensen, Kasper


    's correlation consistent basis sets, it is seen that for larger penalties, the virtual orbitals become more local than the occupied ones. We also show that the local virtual HF orbitals are significantly more local than the redundant projected atomic orbitals, which often have been used to span the virtual......It is demonstrated that a set of local orthonormal Hartree–Fock (HF) molecular orbitals can be obtained for both the occupied and virtual orbital spaces by minimizing powers of the orbital variance using the trust-region algorithm. For a power exponent equal to one, the Boys localization function...... be encountered. These disappear when the exponent is larger than one. For a small penalty, the occupied orbitals are more local than the virtual ones. When the penalty is increased, the locality of the occupied and virtual orbitals becomes similar. In fact, when increasing the cardinal number for Dunning...

  5. Rapid progressive extramedullary plasmacytoma in the orbit. (United States)

    Knecht, P; Schuler, R; Chaloupka, K


    Plasma cell tumors of the orbit are uncommon and mostly the first manifestation of a multiple myeloma (MM). Primary extramedullary plasmacytoma (EMP) of the orbit is exceedingly rare and only a few cases have been reported so far. Differentiation of an EMP from a MM is important, since 9.5 years have been reported as the mean survival of EMP, compared with a mean survival of 3 to 4 years for multiple myeloma. A 68-year-old man presented with a history of rapid progressive extramedullary plasmacytoma in the right orbit, increasing in size within a few weeks. MR imaging revealed an intraorbital mass measuring 5.2 x 4.7 x 3 cm. The earlier performed biopsy was positive for plasmacytoma of the lambda light chain type. Systemic work-up was negative for further tumor spread. Irradiation (a maximum of 80 Gy) and several chemotherapy cycles showed no effect. Exenteration with sparing of the upper and lower lid skin was performed. The residual defect was covered by a Thiersch graft. Although the orbit had been irradiated with the maximal dose, the Thiersch graft healed well. Normally, EMP is slow to increase in size. In our patient, marked growth of tumor was noted within one week. One underlying reason is the poorly differentiated, blastic morphology leading to this rapid tumor growth. However, particular molecular features, like a t(4;14), could not be demonstrated.

  6. Natural excitation orbitals from linear response theories: Time-dependent density functional theory, time-dependent Hartree-Fock, and time-dependent natural orbital functional theory. (United States)

    van Meer, R; Gritsenko, O V; Baerends, E J


    Straightforward interpretation of excitations is possible if they can be described as simple single orbital-to-orbital (or double, etc.) transitions. In linear response time-dependent density functional theory (LR-TDDFT), the (ground state) Kohn-Sham orbitals prove to be such an orbital basis. In contrast, in a basis of natural orbitals (NOs) or Hartree-Fock orbitals, excitations often employ many orbitals and are accordingly hard to characterize. We demonstrate that it is possible in these cases to transform to natural excitation orbitals (NEOs) which resemble very closely the KS orbitals and afford the same simple description of excitations. The desired transformation has been obtained by diagonalization of a submatrix in the equations of linear response time-dependent 1-particle reduced density matrix functional theory (LR-TDDMFT) for the NO transformation, and that of a submatrix in the linear response time-dependent Hartree-Fock (LR-TDHF) equations for the transformation of HF orbitals. The corresponding submatrix is already diagonal in the KS basis in the LR-TDDFT equations. While the orbital shapes of the NEOs afford the characterization of the excitations as (mostly) simple orbital-to-orbital transitions, the orbital energies provide a fair estimate of excitation energies.

  7. Multi-layer canard cycles and translated power functions (United States)

    Dumortier, Freddy; Roussarie, Robert

    The paper deals with two-dimensional slow-fast systems and more specifically with multi-layer canard cycles. These are canard cycles passing through n layers of fast orbits, with n⩾2. The canard cycles are subject to n generic breaking mechanisms and we study the limit cycles that can be perturbed from the generic canard cycles of codimension n. We prove that this study can be reduced to the investigation of the fixed points of iterated translated power functions.

  8. Effect of Administration of Single Dose GnRH Agonist in Luteal Phase on Outcome of ICSI-ET Cycles in Women with Previous History of IVF/ICSI Failure: A Randomized Controlled Trial (United States)

    Zafardoust, Simin; Jeddi-Tehrani, Mahmood; Akhondi, Mohammad Mehdi; Sadeghi, Mohammad Reza; Kamali, Koroush; Mokhtar, Sara; Badehnoosh, Bita; Arjmand-Teymouri, Fatemeh; Fatemi, Farnaz; Mohammadzadeh, Afsaneh


    Background GnRH agonist administration in the luteal phase has been suggested to beneficially affect the outcome of intracytoplasmic sperm injection (ICSI) and embryo transfer (ET) cycles. This blind randomized controlled study evaluates the effect of GnRH (Gonadotropine Releasing Hormone) agonist administration on ICSI outcome in GnRH antagonist ovarian stimulation protocol in women with 2 or more previous IVF/ICSI-ET failures. Methods One hundred IVF failure women who underwent ICSI cycles and stimulated with GnRH antagonist ovarian stimulation protocol, were included in the study. Women were randomly assigned to intervention (received a single dose injection of GnRH agonist (0.1 mg of Decapeptil) subcutaneously 6 days after oocyte retrieval) and control (did not receive GnRH agonist) groups. Implantation and clinical pregnancy rates were the primary outcome measures. Results Although the age of women, the number of embryos transferred in the current cycle and the quality of the transferred embryos were similar in the two groups, there was a significantly higher rate of implantation (Mann Whitney test, p = 0.041) and pregnancy (32.6% vs. 12.5%, p = 0.030, OR = 3.3, 95%CI, 1.08 to 10.4) in the intervention group. Conclusion Our results suggested that, in addition to routine luteal phase support using progesterone, administration of 0.1 mg of Decapeptil 6 days after oocyte retrieval in women with previous history of 2 or more IVF/ICSI failures led to a significant improvement in implantation and pregnancy rates after ICSI following ovarian stimulation with GnRH antagonist protocol. PMID:25927026

  9. Unusual Sclerosing Orbital Pseudotumor Infiltrating Orbits and Maxillofacial Regions

    Directory of Open Access Journals (Sweden)

    Huseyin Toprak


    Full Text Available Idiopathic orbital pseudotumor (IOP is a benign inflammatory condition of the orbit without identifiable local or systemic causes. Bilateral massive orbital involvement and extraorbital extension of the IOP is very rare. We present an unusual case of IOP with bilateral massive orbital infiltration extending into maxillofacial regions and discuss its distinctive magnetic resonance imaging (MRI features that help to exclude other entities during differential diagnoses.

  10. Orbit determination using real tracking data from FY3C-GNOS (United States)

    Xiong, Chao; Lu, Chuanfang; Zhu, Jun; Ding, Huoping


    China is currently developing the BeiDou Navigation Satellite System, also known as BDS. The nominal constellation of BDS (regional), which had been able to provide preliminary regional positioning and navigation functions, was composed of fourteen satellites, including 5 GEO, 5 IGSO and 4 MEO satellites, and was realized by the end of 2013. Global navigation satellite system occultation sounder (GNOS) on board the Fengyun3C (FY3C) satellite, which is the first BDS/GPS compatible radio occultation (RO) sounder in the world, was launched on 23 September 2013. The GNOS instrument is capable of tracking up to 6 BeiDou satellites and more than 8 GPS satellites. We first present a quality analysis using 1-week onboard BDS/GPS measurements collected by GNOS. Satellite visibility, multipath combination and the ratio of cycle slips are analyzed. The analysis of satellite visibility shows that for one week the BDS receiver can track up to 6 healthy satellites. The analysis of multipath combinations (MPC) suggests more multipath present for BDS than GPS for the CA code (B1 MPC is 0.597 m, L1 MPC is 0.326 m), but less multipath for the P code (B2 MPC is 0.421 m, L2 MPC is 0.673 m). More cycle slips occur for the BDS than for the GPS receiver as shown by the ratio of total satellites/cycle slips observed over a 24 h period. Both the maximum value and average of the ratio of cycle slips based on BDS measurements is 72/50.29, which is smaller than 368/278.71 based on GPS measurements. Second, the results of reduced dynamic orbit determination using BDS/GPS code and phase measurements, standalone BDS SPP (Single Point Positioning) kinematic solution and real-time orbit determination using BDS/GPS code measurements are presented and analyzed. Using an overlap analysis, the orbit consistency of FY3C-GNOS is about 3.80 cm. The precision of BDS only solutions is about 22 cm. The precision of FY3C-GNOS orbit with the Helmert variance component estimation are improved slightly after

  11. Theoretical study of valence orbital response to guanine tautomerization in coordinate and momentum spaces

    International Nuclear Information System (INIS)

    Yang, Zejin; Duffy, Patrick; Zhu, Quan; Wang, Feng; Takahashi, Masahiko


    The binding energy spectra and electron momentum spectra of eight stable guanine tautomers are calculated in the complete valence space. The present results show that the canonical keto (C=O) guanine N(9)H tautomer (GU1) possesses the largest dipole moment, molecular electronic spatial extent, molecular hardness value, and the minimum first vertical ionization potential (VIP). Valence orbital profile investigations find that several orbitals remain almost unchanged during tautomerization, such as frontier highest occupied molecular orbital 39a and 18a. Several orbitals with interchanged order and inverse direction in charge spatial orientations are also detected. Outer valence orbitals (with smaller VIPs) show more complex orbital shapes in the momentum space than those of inner ones (larger VIPs) due mainly to the relatively strong inter-orbital interaction and delocalized electronic distributions. Proton rotation along C–O(H) and C–N(H) axes within hexagonal ring causes smaller influence to orbital profiles than those of proton migration within pentagonal and/or hexagonal rings. Orbital variation trends between enol (GU3–GU5) and keto (GU1, GU2, GU6–GU8) tautomers are observed, including the signature orbitals of enol form, the variation tendency of total orbital intensity, and the variation order of the maximum orbital intensity. In the outer valence momentum space (outside 26a), orbital composed by p z electrons show single peak with a gradual increasing peak site from 0.5 a.u. of inner valence orbital to 1.0 a.u. of outer valence orbital, whereas orbitals composed by p x,y electrons form double peaks with respective sites at about 0.5 and 1.5 a.u., only three p x,y -orbitals present single peaks (33a,34a,36a). The general variation trends in the complete valence space for all the valence orbitals on their intensities, peak sites, and orbital components are concluded. (paper)

  12. Low Earth Orbit Satellite’s Orbit Propagation and Determination (United States)


    Institute of Technology Email: Abstract This paper represents orbit propagation and determination of Low Eearth Orbit(LEO...Arichandran, S. H. Tan, T. Bretschneider, High – Presicion Onboard Orbit Determination for Small Satellites - the GPS-Based XNS on X-SAT. 6th Symposium on

  13. Atmospheric CO2 variations on orbital time scale during the Paleocene and Eocene (United States)

    Zeebe, R. E.; Westerhold, T.; Littler, K.; Zachos, J. C.


    Multi-million-year proxy records (d13C, d18O, %CaCO3, Fe, etc.) show prominent variations on orbital time scale during the Paleocene and Eocene. The cycles have been identified at various sites across the globe and preferentially concentrate spectral power at eccentricity and precessional frequencies. It is almost certain that these cycles are an expression of changes in global climate and carbon cycling paced by orbital variations. However, little is currently known about (1) the driving mechanism linking orbital forcing to changes in climate and carbon cycling and (2) the amplitude of atmospheric CO2 variations associated with these cycles. We have used simple and complex carbon cycle models to explore the basic effect of different orbital forcing schemes and noise on the carbon cycle by forcing different carbon cycle parameters. For direct insolation forcing (opposed to eccentricity - tilt - precession), one major challenge is understanding how the system transfers spectral power from high to low frequencies. We will discuss feasible solutions to this problem, including insolation transformations analogous to electronic AC-DC conversion (DC'ing). Our results show that high-latitude mechanisms are unlikely drivers of orbitally paced changes in the Paleocene-Eocene Earth system. Based on a synthesis of modeling and proxy data analysis, we present the first estimates of orbital-scale variations in atmospheric CO2 during the Paleocene and Eocene.

  14. Significance testing of orbital forcing in deep time (United States)

    Kemp, David


    The recognition of orbitally forced (Milankovitch) climate cycles in geological archives marked a paradigm shift in Earth science, revealing a heartbeat within the climate system of general importance and key utility. Resolving orbital cycles in stratigraphic data is, however, problematic owing to the imperfect stratigraphic preservation of climate signals, the masking effects of non-periodic variance, and uncertainties in the expected responses of proxy records to climate change. Power spectral analysis is the primary tool used to facilitate identification of orbital cycles in stratigraphic data, but commonly employed methods for testing the significance of relatively high narrow-band variance of potential orbital origin in spectra have been criticised for inadequately balancing the respective probabilities of type I (false positive) and type II (false negative) errors. This has led to suggestions that the importance of orbital forcing in deep time is overstated [1]. It can be readily demonstrated, however, that the imperfect nature of the stratigraphic record sets an upper limit on the attainable significance of orbital signals. Optimised significance testing is that which minimises the sum of type I and type II errors [2]. Numerical simulations of stratigraphically preserved orbital signals suggest that optimum significance levels at which to reject a null hypothesis of no orbital forcing cluster between 99% and 99.9%. This is lower than recently advocated [1], but higher than the 90-99% levels most commonly employed in the literature. Nevertheless, in consonance with the emergent view from other scientific disciplines, fixed-value null hypothesis significance testing of power spectra is likely ill suited to verifying orbital forcing. In part, this is because the experiments also indicate that the combined probability of making an error in the acceptance or rejection of an orbital hypothesis may be rather high for typical stratigraphic data, and hence the use of

  15. Orbital debris: a technical assessment

    National Research Council Canada - National Science Library

    National Research Council Staff; Commission on Engineering and Technical Systems; Division on Engineering and Physical Sciences; National Research Council; National Academy of Sciences

    ..., and other debris created as a byproduct of space operations. Orbital Debris examines the methods we can use to characterize orbital debris, estimates the magnitude of the debris population, and assesses the hazard that this population poses to spacecraft...

  16. GOC: General Orbit Code

    International Nuclear Information System (INIS)

    Maddox, L.B.; McNeilly, G.S.


    GOC (General Orbit Code) is a versatile program which will perform a variety of calculations relevant to isochronous cyclotron design studies. In addition to the usual calculations of interest (e.g., equilibrium and accelerated orbits, focusing frequencies, field isochronization, etc.), GOC has a number of options to calculate injections with a charge change. GOC provides both printed and plotted output, and will follow groups of particles to allow determination of finite-beam properties. An interactive PDP-10 program called GIP, which prepares input data for GOC, is available. GIP is a very easy and convenient way to prepare complicated input data for GOC. Enclosed with this report are several microfiche containing source listings of GOC and other related routines and the printed output from a multiple-option GOC run

  17. Topics in orbit equivalence

    CERN Document Server

    Kechris, Alexander S


    This volume provides a self-contained introduction to some topics in orbit equivalence theory, a branch of ergodic theory. The first two chapters focus on hyperfiniteness and amenability. Included here are proofs of Dye's theorem that probability measure-preserving, ergodic actions of the integers are orbit equivalent and of the theorem of Connes-Feldman-Weiss identifying amenability and hyperfiniteness for non-singular equivalence relations. The presentation here is often influenced by descriptive set theory, and Borel and generic analogs of various results are discussed. The final chapter is a detailed account of Gaboriau's recent results on the theory of costs for equivalence relations and groups and its applications to proving rigidity theorems for actions of free groups.

  18. Modeling the climatic response to orbital variations. (United States)

    Imbrie, J; Imbrie, J Z


    According to the astronomical theory of climate, variations in the earth's orbit are the fundamental cause of the succession of Pleistocene ice ages. This article summarizes how the theory has evolved since the pioneer studies of James Croll and Milutin Milankovitch, reviews recent evidence that supports the theory, and argues that a major opportunity is at hand to investigate the physical mechanisms by which the climate system responds to orbital forcing. After a survey of the kinds of models that have been applied to this problem, a strategy is suggested for building simple, physically motivated models, and a time-dependent model is developed that simulates the history of planetary glaciation for the past 500,000 years. Ignoring anthropogenic and other possible sources of variation acting at frequencies higher than one cycle per 19,000 years, this model predicts that the long-term cooling trend which began some 6000 years ago will continue for the next 23,000 years.

  19. Dawn Orbit Determination Team: Trajectory Modeling and Reconstruction Processes at Vesta (United States)

    Abrahamson, Matthew J.; Ardito, Alessandro; Han, Dongsuk; Haw, Robert; Kennedy, Brian; Mastrodemos, Nick; Nandi, Sumita; Park, Ryan; Rush, Brian; Vaughan, Andrew


    The Dawn spacecraft spent over a year in orbit around Vesta from July 2011 through August 2012. In order to maintain the designated science reference orbits and enable the transfers between those orbits, precise and timely orbit determination was required. Challenges included low-thrust ion propulsion modeling, estimation of relatively unknown Vesta gravity and rotation models, track-ing data limitations, incorporation of real-time telemetry into dynamics model updates, and rapid maneuver design cycles during transfers. This paper discusses the dynamics models, filter configuration, and data processing implemented to deliver a rapid orbit determination capability to the Dawn project.

  20. Small Mercury Relativity Orbiter (United States)

    Bender, Peter L.; Vincent, Mark A.


    The accuracy of solar system tests of gravitational theory could be very much improved by range and Doppler measurements to a Small Mercury Relativity Orbiter. A nearly circular orbit at roughly 2400 km altitude is assumed in order to minimize problems with orbit determination and thermal radiation from the surface. The spacecraft is spin-stabilized and has a 30 cm diameter de-spun antenna. With K-band and X-band ranging systems using a 50 MHz offset sidetone at K-band, a range accuracy of 3 cm appears to be realistically achievable. The estimated spacecraft mass is 50 kg. A consider-covariance analysis was performed to determine how well the Earth-Mercury distance as a function of time could be determined with such a Relativity Orbiter. The minimum data set is assumed to be 40 independent 8-hour arcs of tracking data at selected times during a two year period. The gravity field of Mercury up through degree and order 10 is solved for, along with the initial conditions for each arc and the Earth-Mercury distance at the center of each arc. The considered parameters include the gravity field parameters of degree 11 and 12 plus the tracking station coordinates, the tropospheric delay, and two parameters in a crude radiation pressure model. The conclusion is that the Earth-Mercury distance can be determined to 6 cm accuracy or better. From a modified worst-case analysis, this would lead to roughly 2 orders of magnitude improvement in the knowledge of the precession of perihelion, the relativistic time delay, and the possible change in the gravitational constant with time.

  1. Plotting Orbital Trajectories For Maneuvers (United States)

    Brody, Adam R.


    Interactive Orbital Trajectory Planning Tool (EIVAN) computer program is forward-looking interactive orbit-trajectory-plotting software tool for use with proximity operations (operations occurring within 1-km sphere of space station) and other maneuvers. Developed to plot resulting trajectories, to provide better comprehension of effects of orbital mechanics, and to help user develop heuristics for planning missions on orbit. Program runs with Microsoft's Excel for execution on MacIntosh computer running MacIntosh OS.

  2. Preseptal and orbital cellulitis

    Directory of Open Access Journals (Sweden)

    Emine Akçay


    Full Text Available Preseptal cellulitis (PC is defined as an inflammation of the eyelid and surrounding skin, whereas orbital cellulitis (OC is an inflammation of the posterior septum of the eyelid affecting the orbit and its contents. Periorbital tissues may become infected as a result of trauma (including insect bites or primary bacteremia. Orbital cellulitis generally occurs as a complication of sinusitis. The most commonly isolated organisms are Staphylococcus aureus, Streptococcus pneumoniae, S. epidermidis, Haempphilus influenzae, Moraxella catarrhalis and S. pyogenes. The method for the diagnosis of OS and PS is computed tomography. Using effective antibiotics is a mainstay for the treatment of PC and OC. There is an agreement that surgical drainage should be performed in cases of complete ophthalmoplegia or significant visual impairment or large abscesses formation. This infections are also at a greater risk of acute visual loss, cavernous sinus thrombosis, meningitis, cerebritis, endophthalmitis, and brain abscess in children. Early diagnosis and appropriate treatment are crucial to control the infection. Diagnosis, treatment, management and complications of PC and OC are summarized in this manuscript. J MicrobiolInfect Dis 2014; 4(3: 123-127

  3. Spin-orbit scattering in superconducting nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Alhassid, Y. [Center for Theoretical Physics, Sloane Physics Laboratory, Yale University, New Haven, Connecticut, 06520 (United States); Nesterov, K.N. [Department of Physics, University of Wisconsin-Madison, Madison, Wisconsin, 53706 (United States)


    We review interaction effects in chaotic metallic nanoparticles. Their single-particle Hamiltonian is described by the proper random-matrix ensemble while the dominant interaction terms are invariants under a change of the single-particle basis. In the absence of spin-orbit scattering, the nontrivial invariants consist of a pairing interaction, which leads to superconductivity in the bulk, and a ferromagnetic exchange interaction. Spin-orbit scattering breaks spin-rotation invariance and when it is sufficiently strong, the only dominant nontrivial interaction is the pairing interaction. We discuss how the magnetic response of discrete energy levels of the nanoparticle (which can be measured in single-electron tunneling spectroscopy experiments) is affected by such pairing correlations and how it can provide a signature of pairing correlations. We also consider the spin susceptibility of the nanoparticle and discuss how spin-orbit scattering changes the signatures of pairing correlations in this observable. (copyright 2016 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  4. Simultaneous monitoring of the two coupled motors of a single FoF1-ATP synthase by three-color FRET using duty cycle-optimized triple-ALEX (United States)

    Zarrabi, N.; Ernst, S.; Düser, M. G.; Golovina-Leiker, A.; Becker, W.; Erdmann, R.; Dunn, S. D.; Börsch, M.


    FoF1-ATP synthase is the enzyme that provides the 'chemical energy currency' adenosine triphosphate, ATP, for living cells. The formation of ATP is accomplished by a stepwise internal rotation of subunits within the enzyme. Briefly, proton translocation through the membrane-bound Fo part of ATP synthase drives a 10-step rotary motion of the ring of c subunits with respect to the non-rotating subunits a and b. This rotation is transmitted to the γ and ɛ subunits of the F1 sector resulting in 120° steps. In order to unravel this symmetry mismatch we monitor subunit rotation by a single-molecule fluorescence resonance energy transfer (FRET) approach using three fluorophores specifically attached to the enzyme: one attached to the F1 motor, another one to the Fo motor, and the third one to a non-rotating subunit. To reduce photophysical artifacts due to spectral fluctuations of the single fluorophores, a duty cycle-optimized alternating three-laser scheme (DCO-ALEX) has been developed. Simultaneous observation of the stepsizes for both motors allows the detection of reversible elastic deformations between the rotor parts of Fo and F1.

  5. Orbital Cellulitis of Odontogenic Origin. (United States)

    Yan, William; Chakrabarti, Rahul; Choong, Jessica; Hardy, Thomas


    Odontogenic orbital cellulitis, although uncommon, has the potential to cause severe vision loss if unsuspected and untreated. Compared to non-odontogenic bacteriology, odontogenic orbital abscesses typically feature a heavy mixed growth with anaerobic organisms. We review the literature and discuss the case of a 26-year-old male who presented with anaerobic orbital cellulitis for treatment.

  6. Orbiter OMS and RCS technology (United States)

    Boudreaux, R. A.


    Orbiter Orbital Maneuver Subsystem (OMS) and Reaction Control Subsystem (RCS) tankage has proved to be highly successful in shuttle flights on-orbit propellant transfer tests were done. Tank qualification tests along with flight demonstrations were carried out future uses of storable propellants are cited.

  7. Retinoblastoma associated orbital cellulitis (United States)

    Mullaney, P.; Karcioglu, Z.; Huaman, A.; Al-Mesfer, S.


    AIM—Preseptal and orbital cellulitis are rare presenting features of intraocular retinoblastoma. The objectives of this study were to determine the frequency of retinoblastoma associated cellulitis, as well as to review its clinical and histopathological features.
METHODS—The medical records of 292 retinoblastoma patients in the King Khaled Eye Specialist Hospital in Riyadh, Saudi Arabia were reviewed. Those indicating a history of, or presenting with, cellulitis were retrieved and their clinical, radiological, and histopathological variables were assessed. Patients with definite extraocular tumour extension on clinical or radiological examination were excluded.
RESULTS—14 patients were found to have retinoblastoma associated cellulitis (4.8%); nine had bilateral and five had unilateral retinoblastoma. Conjunctival and blood cultures were performed in 10 cases and were negative. 10 children were treated with intravenous steroids, often in conjunction with antibiotics, resulting in a prompt decrease in inflammation. Three other children were treated with antibiotics alone and one received no treatment. Computed tomographic scanning depicted large intraocular tumours occupying between 80% and 100% of the globe in each case. In eight patients, periocular inflammation was radiologically interpreted as possible extraocular extension. In one patient serial computed tomographic scanning showed a reduction in intraocular calcification over time which occurred in the presence of cellulitis. 12 patients underwent enucleation and histopathological examination revealed large necrotic, poorly differentiated tumours associated with uveal involvement and early optic nerve invasion. Focal perilimbal destruction was seen in one patient, and in another peripapillary extrascleral extension was present. 12 patients are alive with a mean follow up of 56.4 months.
CONCLUSIONS—Radiological evaluation of scleral integrity may be hindered by periocular inflammatory

  8. Orbital Cellulitis Following Orbital Blow-out Fracture. (United States)

    Byeon, Je Yeon; Choi, Hwan Jun


    Orbital cellulitis and abscess have been described in the literature as complication that usually occur secondary to infection in the maxillary, ethmoidal, and frontal sinuses. If left untreated, it can lead to blindness, cavernous sinus thrombosis, meningitis, or cerebral abscess. Orbital fractures are a common sequela of blunt orbital trauma, but are only rarely associated with orbital cellulitis. So, the authors present rare orbital cellulitis after orbital blow-out fracture. A 55-year-old Asian complains of severe orbital swelling and pain on the left side. These symptoms had started 2 days earlier and worsened within the 24 hours before hospital admission resulting in visual disturbances such as diplopia and photophobia. Contrast-enhanced computed tomography scan showed considerable soft tissue swelling and abscess formation on the left side. Patient was subjected to surgical drainage under general anesthesia in the operation room. In this case, the postoperative period was uneventful and the rapid improvement of symptoms was remarkable. In conclusion, the abscess of the orbit is a surgical emergency in patients whose impairment of vision or ocular symptoms cannot be controlled with medical therapy using antibiotics. In our case, orbital cellulitis can occur after blunt orbital trauma without predisposing sinusitis. Early and prompt diagnosis and surgical drainage before severe loss of visual acuity rescue or recover the vision in case of orbital cellulitis.

  9. Single-staged resections and 3D reconstructions of the nasion, glabella, medial orbital wall, and frontal sinus and bone: Long-term outcome and review of the literature. (United States)

    Ciporen, Jeremy; Lucke-Wold, Brandon P; Mendez, Gustavo; Chen, Anton; Banerjee, Amit; Akins, Paul T; Balough, Ben J


    Aesthetic facial appearance following neurosurgical ablation of frontal fossa tumors is a primary concern for patients and neurosurgeons alike. Craniofacial reconstruction procedures have drastically evolved since the development of three-dimensional computed tomography imaging and computer-assisted programming. Traditionally, two-stage approaches for resection and reconstruction were used; however, these two-stage approaches have many complications including cerebrospinal fluid leaks, necrosis, and pneumocephalus. We present two successful cases of single-stage osteoma resection and craniofacial reconstruction in a 26-year-old female and 65-year-old male. The biopolymer implants were preselected and contoured based on imaging prior to surgery. The ideal selection of appropriate flaps for reconstruction was imperative. The flaps were well vascularized and included a pedicle for easy translocation. Using a titanium mesh biopolymer implant for reconstruction in conjunction with a forehead flap proved advantageous, and the benefits of single-stage approaches were apparent. The patients recovered quickly after the surgery with complete resection of the osteoma and good aesthetic appearance. The flap adhered to the biopolymer implant, and the cosmetic appearance years after surgery remained decent. The gap between the bone and implant was less than 2 mm. The patients are highly satisfied with the symmetrical appearance of the reconstruction. Advances in technology are allowing neurosurgeons unprecedented opportunities to design complex yet feasible single-stage craniofacial reconstructions that improve a patient's quality of life by enhancing facial contours, aesthetics, and symmetry.

  10. Orbit Propagation and Determination of Low Earth Orbit Satellites

    Directory of Open Access Journals (Sweden)

    Ho-Nien Shou


    Full Text Available This paper represents orbit propagation and determination of low Earth orbit (LEO satellites. Satellite global positioning system (GPS configured receiver provides position and velocity measures by navigating filter to get the coordinates of the orbit propagation (OP. The main contradictions in real-time orbit which is determined by the problem are orbit positioning accuracy and the amount of calculating two indicators. This paper is dedicated to solving the problem of tradeoffs. To plan to use a nonlinear filtering method for immediate orbit tasks requires more precise satellite orbit state parameters in a short time. Although the traditional extended Kalman filter (EKF method is widely used, its linear approximation of the drawbacks in dealing with nonlinear problems was especially evident, without compromising Kalman filter (unscented Kalman Filter, UKF. As a new nonlinear estimation method, it is measured at the estimated measurements on more and more applications. This paper will be the first study on UKF microsatellites in LEO orbit in real time, trying to explore the real-time precision orbit determination techniques. Through the preliminary simulation results, they show that, based on orbit mission requirements and conditions using UKF, they can satisfy the positioning accuracy and compute two indicators.

  11. Total-dose hardness assurance for low earth orbit

    International Nuclear Information System (INIS)

    Maurer, R.H.; Suter, J.J.


    The Low Earth Orbit radiation environment has two significant characteristics that make laboratory simulation exposures difficult: (1) a low dose rate and (2) many cycles of low dose accumulation followed by dose-free annealing. Hardness assurance considerations for this environment are discussed and related to data from the testing of Advanced Low Power Schottky and High-speed CMOS devices

  12. Role of oral corticosteroids in orbital cellulitis. (United States)

    Pushker, Neelam; Tejwani, Lalit Kumar; Bajaj, Mandeep S; Khurana, Saurbhi; Velpandian, Thirumurthy; Chandra, Mahesh


    To evaluate the role of oral corticosteroids as an anti-inflammatory adjunct in the treatment of orbital cellulitis. Prospective, comparative, single-masked, interventional clinical study. setting: Tertiary eye care center (All India Institute of Medical Sciences). study population: Patients with acute onset (within 14 days) of orbital cellulitis with or without abscess. intervention: Patients were randomized into 2 groups in the ratio of 1:2. Both groups received initial intravenous antibiotics. In Group 2, oral steroids were added after an initial response to intravenous antibiotics. main outcome measures: Resolution of signs and symptoms, duration of intravenous antibiotics, length of hospital stay, and sequelae of disease (ptosis, proptosis, and movement restriction) were evaluated and compared between the 2 groups. A total of 21 patients (age range, 11-59 years) with orbital cellulitis were studied. There were 7 patients in Group 1, who received standard intravenous antibiotics, and 14 in Group 2, who received adjuvant steroids. Patients in Group 2 showed an earlier resolution of inflammation in terms of periorbital edema (P = .002 at day 7), conjunctival chemosis (P orbital cellulitis may hasten resolution of inflammation with a low risk of exacerbating infection. Copyright © 2013 Elsevier Inc. All rights reserved.

  13. Orbitally forced sedimentary rhythms in the stratigraphic record: is there room for tidal forcing?

    NARCIS (Netherlands)

    Boer, P.L. de; Trabucho Alexandre, J.


    The imprint of orbital cycles, which result from the varying eccentricity of the Earth’s orbit and changes in the orientation of its axis, have been recognised throughout the Phanerozoic rock record. Variations in insolation and their effect on climate are generally considered to be the sole

  14. A Typical Presentation of Orbital Pseudotumor Mimicking Orbital Cellulitis

    Directory of Open Access Journals (Sweden)

    J. Ayatollahi


    Full Text Available Introduction: Orbital pseudotumor, also known as idiopathic orbital inflammatory syndrome (IOIS, is a benign, non- infective inflammatory condition of the orbit without identifiable local or systemic causes. The disease may mimics a variety of pathologic conditions. We pre-sent a case of pseudotumor observed in a patient admitted under the name of orbital celluli-ties. Case Report: A 26-year-old woman reffered to our hospital with the history of left ocular pain and headache 2 days before her visit.. Ophthalmological examination of the patient was normal except for the redness and lid edema, mild chemosis and conjunctival injection. Gen-eral assessment was normal but a low grade fever was observed. She was hospitalized as an orbital cellulitis patient. She was treated with intravenous antibiotics. On the third day , sud-denly diplopia, proptosis in her left eye and ocular pain in her right side appeared. MRI re-vealed bilateral enlargement of extraocular muscles. Diagnosis of orbital pseudotumor was made and the patient was treated with oral steroid.She responded promptly to the treatment. Antibiotics were discontinued and steroid was tapered in one month period under close fol-low up. Conclusion: The clinical features of orbital pseudotumor vary widely . Orbital pseudotumor and orbital cellulitis can occasionally demonstrate overlapping features.. Despite complete physical examination and appropriate imaging, sometimes correct diagnosis of the disease would be difficult (Sci J Hamadan Univ Med Sci 2013; 20 (3:256-259



    Jay Hyoun Kwon; Dorota A. Grejner-Brezinska; Jae Hong Yom; Dong Cheon Lee


    A precise kinematic orbit determination (P-KOD) procedure for Low Earth Orbiter(LEO) using the GPS ion-free triple differenced carrier phases is presented. Because the triple differenced observables provide only relative information, the first epoch`s positions of the orbit should be held fixed. Then, both forward and backward filtering was executed to mitigate the effect of biases of the first epoch`s position. p-KOD utilizes the precise GPS orbits and ground stations data from International...

  16. Lunar Reconnaissance Orbiter (United States)

    Morgan, T.; Chin, G.


    NASA's Lunar Reconnaissance Orbiter (LRO) plans to launch in October 2008 with a companion secondary impactor mission, LCROSS, as the inaugural missions for the Exploration System Mission Directorate. LRO is a pathfinder whose objective is to obtain the needed information to prepare for eventual human return to the Moon. LRO will undertake at least one baseline year of operation with additional extended mission phase sponsored by NASA's Science Mission Directorate. LRO will employ six individual instruments to produce accurate maps and high-resolution images of future landing sites, to assess potential lunar resources, and to characterize the radiation environment. LRO will also test the feasibility of one advanced technology demonstration package. The LRO payload includes: Lunar Orbiter Laser Altimeter (LOLA) which will determine the global topography of the lunar surface at high resolution, measure landing site slopes, surface roughness, and search for possible polar surface ice in shadowed regions; Lunar Reconnaissance Orbiter Camera (LROC) which will acquire targeted narrow angle images of the lunar surface capable of resolving meter-scale features to support landing site selection, as well as wide-angle images to characterize polar illumination conditions and to identify potential resources; Lunar Exploration Neutron Detector (LEND) which will map the flux of neutrons from the lunar surface to search for evidence of water ice, and will provide space radiation environment measurements that may be useful for future human exploration; Diviner Lunar Radiometer Experiment (DLRE) which will chart the temperature of the entire lunar surface at approximately 300 meter horizontal resolution to identify cold-traps and potential ice deposits; Lyman-Alpha Mapping Project (LAMP) which will map the entire lunar surface in the far ultraviolet. LAMP will search for surface ice and frost in the polar regions and provide images of permanently shadowed regions illuminated only

  17. Happy Cycling

    DEFF Research Database (Denmark)

    Geert Jensen, Birgitte; Nielsen, Tom


    og Interaktions Design, Aarhus Universitet under opgave teamet: ”Happy Cycling City – Aarhus”. Udfordringen i studieopgaven var at vise nye attraktive løsningsmuligheder i forhold til cyklens og cyklismens integration i byrum samt at påpege relationen mellem design og overordnede diskussioner af...


    African Journals Online (AJOL)

    changed to gestodene. Although large- scale comparative trials are needed to confirm this finding, evidence suggests that cycle control with gestodene is better than for monophasic preparations containing desogestrel, norgestimate or levonorgestrel,10 as well as for levonorg- estrel-or norethisterone-containing triphasics.

  19. Coordination cycles

    Czech Academy of Sciences Publication Activity Database

    Steiner, Jakub


    Roč. 63, č. 1 (2008), s. 308-327 ISSN 0899-8256 Institutional research plan: CEZ:AV0Z70850503 Keywords : global games * coordination * crises * cycles and fluctuations Subject RIV: AH - Economics Impact factor: 1.333, year: 2008

  20. Coordination cycles

    Czech Academy of Sciences Publication Activity Database

    Steiner, Jakub

    -, č. 274 (2005), s. 1-26 ISSN 1211-3298 Institutional research plan: CEZ:AV0Z70850503 Keywords : coordination * crises * cycles and fluctuations Subject RIV: AH - Economics

  1. ISABELLE closed orbit correction system

    International Nuclear Information System (INIS)

    Parzen, G.


    The proposed closed orbit correction system for the ISABELLE storage accelerators is described. Results given include the initial orbit displacement error expected, the degree of correction that is expected by moving quadrupoles and by exciting dipole correction coils, the limitations on orbit correction due to the number and location of the probes (pick-up electrodes) and the accuracy requirements on the power supplies that stem primarily from the need to keep the two narrow beams in proper collision with each other

  2. Optimum gas turbine cycle for combined cycle power plant

    International Nuclear Information System (INIS)

    Polyzakis, A.L.; Koroneos, C.; Xydis, G.


    The gas turbine based power plant is characterized by its relatively low capital cost compared with the steam power plant. It has environmental advantages and short construction lead time. However, conventional industrial engines have lower efficiencies, especially at part load. One of the technologies adopted nowadays for efficiency improvement is the 'combined cycle'. The combined cycle technology is now well established and offers superior efficiency to any of the competing gas turbine based systems that are likely to be available in the medium term for large scale power generation applications. This paper has as objective the optimization of a combined cycle power plant describing and comparing four different gas turbine cycles: simple cycle, intercooled cycle, reheated cycle and intercooled and reheated cycle. The proposed combined cycle plant would produce 300 MW of power (200 MW from the gas turbine and 100 MW from the steam turbine). The results showed that the reheated gas turbine is the most desirable overall, mainly because of its high turbine exhaust gas temperature and resulting high thermal efficiency of the bottoming steam cycle. The optimal gas turbine (GT) cycle will lead to a more efficient combined cycle power plant (CCPP), and this will result in great savings. The initial approach adopted is to investigate independently the four theoretically possible configurations of the gas plant. On the basis of combining these with a single pressure Rankine cycle, the optimum gas scheme is found. Once the gas turbine is selected, the next step is to investigate the impact of the steam cycle design and parameters on the overall performance of the plant, in order to choose the combined cycle offering the best fit with the objectives of the work as depicted above. Each alterative cycle was studied, aiming to find the best option from the standpoint of overall efficiency, installation and operational costs, maintainability and reliability for a combined power

  3. Orbital science's 'Bermuda Triangle' (United States)

    Sherrill, Thomas J.


    The effects of a part of the inner Van Allen belt lying closest to the earth, known as the South Atlantic Anomaly (SAA) upon spacecraft including the Hubble Space Telescope (HST), are discussed. The area consists of positively charged ions and electrons from the Van Allen Belt which become trapped in the earth's dipole field. Contor maps representing the number of protons per square centimeter per second having energies greater than 10 million electron volts are presented. It is noted that the HST orbit causes it to spend about 15 percent of its time in the SAA, but that, unlike the experience with earlier spacecraft, the satellite's skin, internal structure, and normal electronic's packaging provides sufficient protection against eletrons, although some higher energy protons still get through. Various charged particle effects which can arise within scientific instruments including fluorescence, Cerenkov radiation, and induced radioactivity are described.

  4. Orbital Eccrine Hidrocystoma

    Directory of Open Access Journals (Sweden)

    Deniz Marangoz


    Full Text Available A 29-year-old female patient presented with a painless mass on her upper eyelid medially. She noticed the mass 4 years earlier and it had increased in size over time. She had no diplopia, eyelid swelling, skin lesion overlying the mass, or visual disturbances. On ocular examination, eye movements and funduscopy were normal. The mass was movable and painless with palpation. Magnetic resonance imaging with contrast showed a 12x8x7 mm well-circumscribed cystic lesion with no contrast dye appearance. Surgical removal was performed delicately and no capsular rupture occured. Pathological examination revealed an eccrine hidrocystoma. Our aim is to underline that eccrine hidrocystoma should be included in differential diagnosis of orbital masses.

  5. Exploratory orbit analysis

    International Nuclear Information System (INIS)

    Michelotti, L.


    Unlike the other documents in these proceedings, this paper is neither a scientific nor a technical report. It is, rather, a short personal essay which attempts to describe an Exploratory Orbit Analysis (EOA) environment. Analyzing the behavior of a four or six dimensional nonlinear dynamical system is at least as difficult as analyzing events in high-energy collisions; the consequences of doing it badly, or slowly, would be at least as devastating; and yet the level of effort and expenditure invested in the latter, the very attention paid to it by physicists at large, must be two orders of magnitude greater than that given to the former. It is difficult to choose the model which best explains the behavior of a physical device if one does not first understand the behavior of the available models. The time is ripe for the development of a functioning EOA environment, which I will try to describe in this paper to help us achieve this goal

  6. Solitonic natural orbitals (United States)

    Cioslowski, Jerzy


    The dependence of the natural amplitudes of the harmonium atom in its ground state on the confinement strength ω is thoroughly investigated. A combination of rigorous analysis and extensive, highly accurate numerical calculations reveals the presence of only one positive-valued natural amplitude ("the normal sign pattern") for all ω ≥1/2 . More importantly, it is shown that unusual, weakly occupied natural orbitals (NOs) corresponding to additional positive-valued natural amplitudes emerge upon sufficient weakening of the confinement. These solitonic NOs, whose shapes remain almost invariant as their radial positions drift toward infinity upon the critical values of ω being approached from below, exhibit strong radial localization. Their asymptotic properties are extracted from the numerical data and their relevance to calculations on fully Coulombic systems is discussed.

  7. Orbital myositis in scleritis (United States)

    Boonman, Z F H M; de Keizer, R J W; Graniewski-Wijnands, H S; Watson, P G


    Aims: To investigate the association between scleritis and myositis. Methods: Retrospective, non-comparative case series. Records and ultrasonograms were examined of 132 patients, with a diagnosis of episcleritis or scleritis, who attended the ophthalmology department at Leiden University Medical Center between 1997 and 2000. 103 were eligible for comprehensive examination. Medical records were evaluated. Ultrasonography was performed in all patients diagnosed with episcleritis or scleritis. Clinical features, precipitating factors, systemic associations, ocular complications, treatment, and outcome of each patient were assessed. Results: Of the 103 patients, 27 (26.2%) had episcleritis and 76 (73.8%) had scleritis. Myositis was found to be present in 11 patients. It was present in 14.5% of all patients with scleritis and 30.5% of those in whom the posterior sclera was affected. The presence of the associated myositis did not worsen the visual prognosis and the presence of myositis was not associated with other systemic diseases. There were no cases of unilateral scleritis with bilateral orbital myositis. During an attack ocular complications were more common in patients with scleritis and myositis (64%) than in patients with scleritis alone (30.4%), indicating a more diffuse and potentially dangerous inflammation. There was no evidence that the inflammatory changes in the orbit had spread to involve the sclera, so it is assumed that the muscle changes are an extension of a generalised response to intense inflammation of the episclera and sclera. Conclusion: This study found a frequent association between myositis and scleritis. Prognosis for vision was not affected by coexistence of myositis. PMID:12488260

  8. The conservation of orbital symmetry

    CERN Document Server

    Woodward, R B


    The Conservation of Orbital Symmetry examines the principle of conservation of orbital symmetry and its use. The central content of the principle was that reactions occur readily when there is congruence between orbital symmetry characteristics of reactants and products, and only with difficulty when that congruence does not obtain-or to put it more succinctly, orbital symmetry is conserved in concerted reaction. This principle is expected to endure, whatever the language in which it may be couched, or whatever greater precision may be developed in its application and extension. The book ope

  9. CDDIS_DORIS_products_orbit (United States)

    National Aeronautics and Space Administration — Precise satellite orbits derived from analysis of Doppler Orbitography by Radiopositioning Integrated on Satellite (DORIS) data. These products are the generated by...

  10. On-Orbit Quantitative Real-Time Gene Expression Analysis Using the Wetlab-2 System (United States)

    Parra, Macarena; Jung, Jimmy; Almeida, Eduardo; Boone, Travis; Tran, Luan; Schonfeld, Julie


    NASA Ames Research Center's WetLab-2 Project enables on-orbit quantitative Reverse Transcriptase PCR (qRT-PCR) analysis without the need for sample return. The WetLab-2 system is capable of processing sample types ranging from microbial cultures to animal tissues dissected on-orbit. The project developed a RNA preparation module that can lyse cells and extract RNA of sufficient quality and quantity for use as templates in qRT-PCR reactions. Our protocol has the advantage of using non-toxic chemicals and does not require alcohols or other organics. The resulting RNA is dispensed into reaction tubes that contain all lyophilized reagents needed to perform qRT-PCR reactions. System operations require simple and limited crew actions including syringe pushes, valve turns and pipette dispenses. The project selected the Cepheid SmartCycler (TradeMark), a Commercial-Off-The-Shelf (COTS) qRT-PCR unit, because of its advantages including rugged modular design, low power consumption, rapid thermal ramp times and four-color multiplex detection. Single tube multiplex assays can be used to normalize for RNA concentration and integrity, and to study multiple genes of interest in each module. The WetLab-2 system can downlink data from the ISS to the ground after a completed run and uplink new thermal cycling programs. The ability to conduct qRT-PCR and generate results on-orbit is an important step towards utilizing the ISS as a National Laboratory facility. Specifically, the ability to get on-orbit data will provide investigators with the opportunity to adjust experimental parameters in real time without the need for sample return and re-flight. On orbit gene expression analysis can also eliminate the confounding effects on gene expression of reentry stresses and shock acting on live cells and organisms or the concern of RNA degradation of fixed samples and provide on-orbit gene expression benchmarking prior to sample return. Finally, the system can also be used for analysis of

  11. Orbital State Manipulation of a Diamond Nitrogen-Vacancy Center Using a Mechanical Resonator (United States)

    Chen, H. Y.; MacQuarrie, E. R.; Fuchs, G. D.


    We study the resonant optical transitions of a single nitrogen-vacancy (NV) center that is coherently dressed by a strong mechanical drive. Using a gigahertz-frequency diamond mechanical resonator that is strain coupled to a NV center's orbital states, we demonstrate coherent Raman sidebands out to the ninth order and orbital-phonon interactions that mix the two excited-state orbital branches. These interactions are spectroscopically revealed through a multiphonon Rabi splitting of the orbital branches which scales as a function of resonator driving amplitude and is successfully reproduced in a quantum model. Finally, we discuss the application of mechanical driving to engineering NV-center orbital states.

  12. PyORBIT: A Python Shell For ORBIT

    International Nuclear Information System (INIS)

    Jean-Francois Ostiguy; Jeffrey Holmes


    ORBIT is code developed at SNS to simulate beam dynamics in accumulation rings and synchrotrons. The code is structured as a collection of external C++ modules for SuperCode, a high level interpreter shell developed at LLNL in the early 1990s. SuperCode is no longer actively supported and there has for some time been interest in replacing it by a modern scripting language, while preserving the feel of the original ORBIT program. In this paper, we describe a new version of ORBIT where the role of SuperCode is assumed by Python, a free, well-documented and widely supported object-oriented scripting language. We also compare PyORBIT to ORBIT from the standpoint of features, performance and future expandability

  13. Orbital Chondroma: A rare mesenchymal tumor of orbit

    Directory of Open Access Journals (Sweden)

    Ruchi S Kabra


    Full Text Available While relatively common in the skeletal system, cartilaginous tumors are rarely seen originating from the orbit. Here, we report a rare case of an orbital chondroma. A 27-year-old male patient presented with a painless hard mass in the superonasal quadrant (SNQ of left orbit since 3 months. On examination, best-corrected visual acuity of both eyes was 20/20, with normal anterior and posterior segment with full movements of eyeballs and normal intraocular pressure. Computerized tomography scan revealed well defined soft tissue density lesion in SNQ of left orbit. Patient was operated for anteromedial orbitotomy under general anesthesia. Mass was excised intact and sent for histopathological examination (HPE. HPE report showed lobular aggregates of benign cartilaginous cells with mild atypia suggesting of benign cartilaginous tumor - chondroma. Very few cases of orbital chondroma have been reported in literature so far.

  14. PyORBIT: A Python Shell For ORBIT

    Energy Technology Data Exchange (ETDEWEB)

    Jean-Francois Ostiguy; Jeffrey Holmes


    ORBIT is code developed at SNS to simulate beam dynamics in accumulation rings and synchrotrons. The code is structured as a collection of external C++ modules for SuperCode, a high level interpreter shell developed at LLNL in the early 1990s. SuperCode is no longer actively supported and there has for some time been interest in replacing it by a modern scripting language, while preserving the feel of the original ORBIT program. In this paper, we describe a new version of ORBIT where the role of SuperCode is assumed by Python, a free, well-documented and widely supported object-oriented scripting language. We also compare PyORBIT to ORBIT from the standpoint of features, performance and future expandability.

  15. Understanding Single Adulthood. (United States)

    Stein, Peter J.

    The life styles and life chances of the unmarried include elements of choices. Singles may be grouped and characterized according to whether their status may be considered stable or temporary. A life cycle, or continuum model of singlehood is reviewed, including its different factors, or phases. A new model for singles is proposed--a life spiral…

  16. Solar Radiation Pressure Binning for the Geosynchronous Orbit (United States)

    Hejduk, M. D.; Ghrist, R. W.


    Orbital maintenance parameters for individual satellites or groups of satellites have traditionally been set by examining orbital parameters alone, such as through apogee and perigee height binning; this approach ignored the other factors that governed an individual satellite's susceptibility to non-conservative forces. In the atmospheric drag regime, this problem has been addressed by the introduction of the "energy dissipation rate," a quantity that represents the amount of energy being removed from the orbit; such an approach is able to consider both atmospheric density and satellite frontal area characteristics and thus serve as a mechanism for binning satellites of similar behavior. The geo-synchronous orbit (of broader definition than the geostationary orbit -- here taken to be from 1300 to 1800 minutes in orbital period) is not affected by drag; rather, its principal non-conservative force is that of solar radiation pressure -- the momentum imparted to the satellite by solar radiometric energy. While this perturbation is solved for as part of the orbit determination update, no binning or division scheme, analogous to the drag regime, has been developed for the geo-synchronous orbit. The present analysis has begun such an effort by examining the behavior of geosynchronous rocket bodies and non-stabilized payloads as a function of solar radiation pressure susceptibility. A preliminary examination of binning techniques used in the drag regime gives initial guidance regarding the criteria for useful bin divisions. Applying these criteria to the object type, solar radiation pressure, and resultant state vector accuracy for the analyzed dataset, a single division of "large" satellites into two bins for the purposes of setting related sensor tasking and orbit determination (OD) controls is suggested. When an accompanying analysis of high area-to-mass objects is complete, a full set of binning recommendations for the geosynchronous orbit will be available.

  17. Precise orbit determination of the Sentinel-3A altimetry satellite using ambiguity-fixed GPS carrier phase observations (United States)

    Montenbruck, Oliver; Hackel, Stefan; Jäggi, Adrian


    The Sentinel-3 mission takes routine measurements of sea surface heights and depends crucially on accurate and precise knowledge of the spacecraft. Orbit determination with a targeted uncertainty of less than 2 cm in radial direction is supported through an onboard Global Positioning System (GPS) receiver, a Doppler Orbitography and Radiopositioning Integrated by Satellite instrument, and a complementary laser retroreflector for satellite laser ranging. Within this study, the potential of ambiguity fixing for GPS-only precise orbit determination (POD) of the Sentinel-3 spacecraft is assessed. A refined strategy for carrier phase generation out of low-level measurements is employed to cope with half-cycle ambiguities in the tracking of the Sentinel-3 GPS receiver that have so far inhibited ambiguity-fixed POD solutions. Rather than explicitly fixing double-difference phase ambiguities with respect to a network of terrestrial reference stations, a single-receiver ambiguity resolution concept is employed that builds on dedicated GPS orbit, clock, and wide-lane bias products provided by the CNES/CLS (Centre National d'Études Spatiales/Collecte Localisation Satellites) analysis center of the International GNSS Service. Compared to float ambiguity solutions, a notably improved precision can be inferred from laser ranging residuals. These decrease from roughly 9 mm down to 5 mm standard deviation for high-grade stations on average over low and high elevations. Furthermore, the ambiguity-fixed orbits offer a substantially improved cross-track accuracy and help to identify lateral offsets in the GPS antenna or center-of-mass (CoM) location. With respect to altimetry, the improved orbit precision also benefits the global consistency of sea surface measurements. However, modeling of the absolute height continues to rely on proper dynamical models for the spacecraft motion as well as ground calibrations for the relative position of the altimeter reference point and the CoM.

  18. Orbital Dynamics and Habitability of Exoplanets (United States)

    Deitrick, Russell J.

    's Pleistocene ice ages. Mutual inclinations lead not only to larger variations in a planet's obliquity, but also uncover secular spin-orbit resonances, which lead to yet more dramatic behavior. I modeled the obliquity evolution of planets in this highly non-linear dynamical regime. Connecting the dynamical models to an simple climate model with ice sheets, I modeled the effects of such dynamical evolution on an Earth-like planet's climate. As expected, such "exo-Milankovitch cycles" can be rapid and dramatic, often leading to complete collapse into a snowball state. By demonstrating a handful of the many ways dynamics can influence habitability, this research provides context to observations of exoplanets and connects to one of the key goals of astrobiology, to "Determine the potential for habitable planets beyond the Solar System, and characterize those that are observable" (Des Marais et al., 2008). It provides tools and techniques that may be used to help prioritize exoplanet targets for characterization missions when very little information is known other than orbital properties. It also demonstrates how orbital evolution affects observable quantities like albedo, and will assist in the interpretation of spectra.

  19. Fuel cycle

    International Nuclear Information System (INIS)

    Bahm, W.


    The situation of the nuclear fuel cycle for LWR type reactors in France and in the Federal Republic of Germany was presented in 14 lectures with the aim to compare the state-of-the-art in both countries. In addition to the momentarily changing fuilds of fuel element development and fueling strategies, the situation of reprocessing, made interesting by some recent developmnts, was portrayed and differences in ultimate waste disposal elucidated. (orig.) [de

  20. Solar Wind Variation with the Cycle

    Indian Academy of Sciences (India)


    Jan 27, 2016 ... The average solar wind density, velocity and temperature measured at the Earth's orbit show specific decadal variations and trends, which are of the order of the first tens per cent during the last three solar cycles. Statistical, spectral and correlation characteristics of the solar wind are reviewed with the ...

  1. Attractor merging crisis in chaotic business cycles

    International Nuclear Information System (INIS)

    Chian, Abraham C.-L.; Borotto, Felix A.; Rempel, Erico L.; Rogers, Colin


    A numerical study is performed on a forced-oscillator model of nonlinear business cycles. An attractor merging crisis due to a global bifurcation is analyzed using the unstable periodic orbits and their associated stable and unstable manifolds. Characterization of crisis can improve our ability to forecast sudden major changes in economic systems

  2. A LEO Hyperspectral Mission Implementation for Global Carbon Cycle Observations (United States)

    Gervin, Janette C.; Esper, Jaime; McClain, Charles R.; Hall, Forrest G.; Middleton, Elizabeth M.; Gregg, Watson W.; Mannino, Antonio; Knox, Robert G.; Huemmrich, K. Fred


    For both terrestrial and ocean carbon cycle science objectives, high resolution (less than l0 nm) imaging spectrometers capable of acquiring multiple regional to global scale observations per day should enable the development of new remote sensing measurements for important but as yet unobservable variables, with the overall goal of linking both terrestrial and ocean carbon cycle processes to climate variability. For terrestrial research, accurate estimates of carbon, water and energy (CWE) exchange between the terrestrial biosphere and atmosphere a needed to id- the geographical locations and temporal dynamics of carbon sources/sinks and to improve regional climate models and climate change assessments. It is an enormous challenge to estimate CWE exchange from the infrequent temporal coverage and sparse spectral information provided by most single polar-orbiting, earth-looking satellite. The available satellite observations lack a sufficient number of well-placed narrow bands from which to derive spectral indices that capture vegetation responses to stress conditions associated with down-regulation of photosynthesis. Physiological status can best be assessed with spectral indices based on continuous, narrow bands in the visible/near infrared spectra, as can seasonal and annual terrestrial productivity. For coastal and ocean constituents, narrow-band observations in the ultraviolet and visible are essential to investigate the variability, dynamics and biogeochemical cycles of the world's coastal and open ocean regions, which will in turn help in measuring ocean productivity and predicting the variability of ocean carbon uptake and its role in climate change.

  3. Plasmablastic lymphoma mimicking orbital cellulitis.

    NARCIS (Netherlands)

    Barkhuysen, R.; Merkx, M.A.W.; Weijs, W.L.J.; Gerlach, N.L.; Berge, S.J.


    INTRODUCTION: Orbital cellulitis is an uncommon, potentially devastating condition that, when not promptly and adequately treated, can lead to serious sequelae. The presenting clinical signs are proptosis, swelling, ophthalmoplegia, pain and redness of the peri-orbital tissues. A number of cases

  4. Generating realistic synthetic meteoroid orbits (United States)

    Vida, Denis; Brown, Peter G.; Campbell-Brown, Margaret


    Context. Generating a synthetic dataset of meteoroid orbits is a crucial step in analysing the probabilities of random grouping of meteoroid orbits in automated meteor shower surveys. Recent works have shown the importance of choosing a low similarity threshold value of meteoroid orbits, some pointing out that the recent meteor shower surveys produced false positives due to similarity thresholds which were too high. On the other hand, the methods of synthetic meteoroid orbit generation introduce additional biases into the data, thus making the final decision on an appropriate threshold value uncertain. Aims. As a part of the ongoing effort to determine the nature of meteor showers and improve automated methods, it was decided to tackle the problem of synthetic meteoroid orbit generation, the main goal being to reproduce the underlying structure and the statistics of the observed data in the synthetic orbits. Methods. A new method of generating synthetic meteoroid orbits using the Kernel Density Estimation method is presented. Several types of approaches are recommended, depending on whether one strives to preserve the data structure, the data statistics or to have a compromise between the two. Results. The improvements over the existing methods of synthetic orbit generation are demonstrated. The comparison between the previous and newly developed methods are given, as well as the visualization tools one can use to estimate the influence of different input parameters on the final data.

  5. Endoscopic treatment of orbital tumors. (United States)

    Signorelli, Francesco; Anile, Carmelo; Rigante, Mario; Paludetti, Gaetano; Pompucci, Angelo; Mangiola, Annunziato


    Different orbital and transcranial approaches are performed in order to manage orbital tumors, depending on the location and size of the lesion within the orbit. These approaches provide a satisfactory view of the superior and lateral aspects of the orbit and the optic canal but involve risks associated with their invasiveness because they require significant displacement of orbital structures. In addition, external approaches to intraconal lesions may also require deinsertion of extraocular muscles, with subsequent impact on extraocular mobility. Recently, minimally invasive techniques have been proposed as valid alternative to external approaches for selected orbital lesions. Among them, transnasal endoscopic approaches, "pure" or combined with external approaches, have been reported, especially for intraconal lesions located inferiorly and medially to the optic nerve. The avoidance of muscle detachment and the shortness of the surgical intraorbital trajectory makes endoscopic approach less invasive, thus minimizing tissue damage. Endoscopic surgery decreases the recovery time and improves the cosmetic outcome not requiring skin incisions. The purpose of this study is to review and discuss the current surgical techniques for orbital tumors removal, focusing on endoscopic approaches to the orbit and outlining the key anatomic principles to follow for safe tumor resection.

  6. [Enophthalmos in an orbital tumor]. (United States)

    Szabo, Bianca; Szabo, I; Nicula, Cristina; Popescu, Livia Adriana


    Enophtalmus is an unusual sign of the orbital tumors often represented by proptosis. One patient with enophtalmus and intraorbital tumor and aplasy is presented. The treatment of choice of orbital tumor is complete surgical excision and careful follow-up. Considering the more aggressive course followed by recurrent tumor, correct diagnosis and management is essential.

  7. Diplopia and Orbital Wall Fractures

    NARCIS (Netherlands)

    Boffano, P.; Roccia, F.; Gallesio, C.; Karagozoglu, K.H.; Forouzanfar, T.


    Diplopia is a symptom that is frequently associated with orbital wall fractures. The aim of this article was to present the incidence and patterns of diplopia after orbital wall blow-out fractures in 2 European centers, Turin and Amsterdam, and to identify any correlation between this symptom and

  8. Diplopia and orbital wall fractures

    NARCIS (Netherlands)

    Boffano, P.; Roccia, F.; Gallesio, C.; Karagozoglu, K.H.; Forouzanfar, T.


    Diplopia is a symptom that is frequently associated with orbital wall fractures. The aim of this article was to present the incidence and patterns of diplopia after orbital wall blow-out fractures in 2 European centers, Turin and Amsterdam, and to identify any correlation between this symptom and

  9. Resonantly enhanced inner-orbital ionization in molecular iodine (United States)

    Smith, Dale L.; Gibson, George N.


    We present a wavelength study of the strong-field single-electron ionization of molecular iodine near its one-photon B -state resonance at 530 nm. We have previously identified two ionization channels [Phys. Rev. A 95, 013410 (2017), 10.1103/PhysRevA.95.013410]: ionization of the high-lying molecular orbitals and ionization of the deep orbitals in I2. We find a resonant enhancement of both channels, although the peak enhancement occurs at different wavelengths for the different channels. Moreover, the branching ratio of the ionization of the deep orbitals shows a dispersion-like function, with the branching ratio of the deep orbitals reaching over 98% at 519 nm. Finally, the branching ratio of double ionization into an excited state of I22+ as a function of wavelength closely matches the branching ratio of the single ionization of deep orbitals, implying that excitation of molecular ions generally comes about through inner orbital ionization. These findings are inconsistent with current molecular ionization theory.

  10. Plasmablastic lymphoma mimicking orbital cellulitis (United States)

    Merkx, Matthias A. W.; Weijs, Willem L. J.; Gerlach, Niek L.; Bergé, Stefaan J.


    Introduction Orbital cellulitis is an uncommon, potentially devastating condition that, when not promptly and adequately treated, can lead to serious sequelae. The presenting clinical signs are proptosis, swelling, ophthalmoplegia, pain and redness of the peri-orbital tissues. A number of cases have been reported in which these symptoms have been mistakenly interpreted as being secondary to an orbital infection whilst, in fact, other pathology was present. Discussion We add another case in which, on clinical grounds and after radiological assessment and laboratory tests, a working diagnosis of orbital cellulitis of the left eye was made. It was only after histopathological analysis of a soft tissue specimen from the maxillary sinus that a diagnosis of an AIDS-related plasmablastic lymphoma was made. The patient was referred to the department of haematology where chemotherapeutic treatment for the lymphoma and the HIV infection was started. This case report adds another differential diagnosis of orbital cellulitis to the existing literature. PMID:18597126

  11. Observing the Global Water Cycle from Space (United States)

    Hildebrand, P. H.


    This paper presents an approach to measuring all major components of the water cycle from space. Key elements of the global water cycle are discussed in terms of the storage of water-in the ocean, air, cloud and precipitation, in soil, ground water, snow and ice, and in lakes and rivers, and in terms of the global fluxes of water between these reservoirs. Approaches to measuring or otherwise evaluating the global water cycle are presented, and the limitations on known accuracy for many components of the water cycle are discussed, as are the characteristic spatial and temporal scales of the different water cycle components. Using these observational requirements for a global water cycle observing system, an approach to measuring the global water cycle from space is developed. The capabilities of various active and passive microwave instruments are discussed, as is the potential of supporting measurements from other sources. Examples of space observational systems, including TRMM/GPM precipitation measurement, cloud radars, soil moisture, sea surface salinity, temperature and humidity profiling, other measurement approaches and assimilation of the microwave and other data into interpretative computer models are discussed to develop the observational possibilities. The selection of orbits is then addressed, for orbit selection and antenna size/beamwidth considerations determine the sampling characteristics for satellite measurement systems. These considerations dictate a particular set of measurement possibilities, which are then matched to the observational sampling requirements based on the science. The results define a network of satellite instrumentation systems, many in low Earth orbit, a few in geostationary orbit, and all tied together through a sampling network that feeds the observations into a data-assimilative computer model.

  12. Non-Exenteration Management of Sino-Orbital Fungal Disease. (United States)

    Athavale, Dnyaneshwar D; Jones, Robin; O'Donnell, Brett A; Forer, Martin; Biggs, Nigel

    To describe the non-exenteration management of sino-orbital fungal infection, a life-threatening condition for which orbital exenteration is generally considered a first-line treatment. A retrospective case series is presented of 7 orbits in 6 consecutive patients admitted and treated at 2 major metropolitan tertiary teaching hospitals in Sydney, New South Wales, Australia. Seven orbits in 6 consecutive patients with sino-orbital fungal infection were treated conservatively with surgical debridement and intravenous antifungal agents. Four patients were immunosuppressed and the other 2 patients were otherwise healthy. All presented with pain, proptosis, or loss of vision. Causative organisms found were Mucormycoses, Aspergillus, and Scedosporium prolificans. Exenteration was avoided in all patients as part of their planned management and 5 patients, including 1 with bilateral disease, survived their disease without exenteration. Medical treatment included intravenous liposomal amphotericin B or voriconazole. A single immunosuppressed patient deteriorated and as a last resort, exenteration was performed, but this made no difference to his clinical course and in retrospect could have been avoided as he died of multiple cerebral metastases diagnosed shortly after his deterioration. The authors recommend that patients with sino-orbital fungal disease preferably be treated conservatively, without orbital exenteration.

  13. Optimal Orbit Design for the Magnetospheric Imaging Constellation (United States)

    Hughes, Steven P.; Bauer, Frank H. (Technical Monitor)


    The Magnetospheric Imaging Constellation (MagIC) is a NASA space science concept to study the Earth's Magnetosphere. The concept proposes to apply tomography techniques using an array of spacecraft to obtain three dimensional images of the Earth's magnetosphere. This paper presents an optimal orbit design to ensure that the constellation is in the desired region of the magnetosphere for maximum time. The solution is found using a steepest descent optimization algorithm that takes into account perturbations from the non-spherical Earth, drag, Sun, Moon and other significant bodies. The solution also satisfies constraints on maximum eclipse duration and geometry constraints to allow an adequate GPS navigation solution. We present three solutions depending upon the epoch of the primary science: vernal equinox, summer solstice, and a third midway between the vernal equinox and summer solstice. Orbit insertion is also considered. All spacecraft are assumed to be launched on a single vehicle into a nominal orbit and the (Delta)V's to achieve the nominal orbit are presented. After insertion into the nominal orbit, each spacecraft undergoes a phasing maneuver to place it in the appropriate position with respect to the rest of the constellation. We present a minimum fuel approach to maneuver each spacecraft from the nominal orbit into the desired final orbit.

  14. Pumped double quantum dot with spin-orbit coupling

    Directory of Open Access Journals (Sweden)

    Sherman Eugene


    Full Text Available Abstract We study driven by an external electric field quantum orbital and spin dynamics of electron in a one-dimensional double quantum dot with spin-orbit coupling. Two types of external perturbation are considered: a periodic field at the Zeeman frequency and a single half-period pulse. Spin-orbit coupling leads to a nontrivial evolution in the spin and orbital channels and to a strongly spin- dependent probability density distribution. Both the interdot tunneling and the driven motion contribute into the spin evolution. These results can be important for the design of the spin manipulation schemes in semiconductor nanostructures. PACS numbers: 73.63.Kv,72.25.Dc,72.25.Pn

  15. Nuclear electric power for multimegawatt orbit transfer vehicles (United States)

    Casagrande, R. D.


    Multimegawatt nuclear propulsion is an attractive option for orbit transfer vehicles. The masses of these platforms are expected to exceed the capability of a single launch from Earth necessitating assembly in space in a parking orbit. The OTV would transfer the platform from the parking orbit to the operational orbit and then return for the next mission. Electric propulsion is advantageous because of the high specific impulse achieved by the technology, 1000 to 5000 s and beyond, to reduce the propellant required. Nuclear power is attractive as the power system because of the weight savings over solar systems in the multimegawatt regime, and multimegawatts of power are required. A conceptual diagram is shown of an OTV with a command control module using electric thrusters powered from an SP-100 class nuclear reactor power system.

  16. Valley-orbit hybrid states in Si quantum dots (United States)

    Gamble, John; Friesen, Mark; Coppersmith, S. N.


    The conduction band for electrons in layered Si nanostructures oriented along (001) has two low-lying valleys. Most theoretical treatments assume that these valleys are decoupled from the long-wavelength physics of electron confinement. In this work, we show that even a minimal amount of disorder (a single atomic step at the quantum well interface) is sufficient to mix valley states and electron orbitals, causing a significant distortion of the long-wavelength electron envelope. For physically realistic electric fields and dot sizes, this valley-orbit coupling impacts all electronic states in Si quantum dots, implying that one must always consider valley-orbit hybrid states, rather than distinct valley and orbital degrees of freedom. We discuss the ramifications of our results on silicon quantum dot qubits. This work was supported in part by ARO (W911NF-08-1-0482) and NSF (DMR-0805045).

  17. Orbital Forcing driving climate variability on Tropical South Atlantic (United States)

    Oliveira, A. S.; Baker, P. A.; Silva, C. G.; Dwyer, G. S.; Chiessi, C. M.; Rigsby, C. A.; Ferreira, F.


    Past research on climate response to orbital forcing in tropical South America has emphasized on high precession cycles influencing low latitude hydrologic cycles, and driving the meridional migration of Intertropical Convergence Zone (ITCZ).However, marine proxy records from the tropical Pacific Ocean showed a strong 41-ka periodicities in Pleistocene seawater temperature and productivity related to fluctuations in Earth's obliquity. It Indicates that the western Pacific ITCZ migration was influenced by combined precession and obliquity changes. To reconstruct different climate regimes over the continent and understand the orbital cycle forcing over Tropical South America climate, hydrological reconstruction have been undertaken on sediment cores located on the Brazilian continental slope, representing the past 1.6 million years. Core CDH 79 site is located on a 2345 m deep seamount on the northern Brazilian continental slope (00° 39.6853' N, 44° 20.7723' W), 320 km from modern coastline of the Maranhão Gulf. High-resolution XRF analyses of Fe, Ti, K and Ca are used to define the changes in precipitation and sedimentary input history of Tropical South America. The response of the hydrology cycle to orbital forcing was studied using spectral analysis.The 1600 ka records of dry/wet conditions presented here indicates that orbital time-scale climate change has been a dominant feature of tropical climate. We conclude that the observed oscillation reflects variability in the ITCZ activity associated with the Earth's tilt. The prevalence of the eccentricity and obliquity signals in continental hydrology proxies (Ti/Ca and Fe/K) as implicated in our precipitation records, highlights that these orbital forcings play an important role in tropics hydrologic cycles. Throughout the Quaternary abrupt shifts of tropical variability are temporally correlated with abrupt climate changes and atmospheric reorganization during Mid-Pleistocene Transition and Mid-Brunhes Events

  18. Spin-orbit torques in magnetic bilayers (United States)

    Haney, Paul


    Spintronics aims to utilize the coupling between charge transport and magnetic dynamics to develop improved and novel memory and logic devices. Future progress in spintronics may be enabled by exploiting the spin-orbit coupling present at the interface between thin film ferromagnets and heavy metals. In these systems, applying an in-plane electrical current can induce magnetic dynamics in single domain ferromagnets, or can induce rapid motion of domain wall magnetic textures. There are multiple effects responsible for these dynamics. They include spin-orbit torques and a chiral exchange interaction (the Dzyaloshinskii-Moriya interaction) in the ferromagnet. Both effects arise from the combination of ferromagnetism and spin-orbit coupling present at the interface. There is additionally a torque from the spin current flux impinging on the ferromagnet, arising from the spin hall effect in the heavy metal. Using a combination of approaches, from drift-diffusion to Boltzmann transport to first principles methods, we explore the relative contributions to the dynamics from these different effects. We additionally propose that the transverse spin current is locally enhanced over its bulk value in the vicinity of an interface which is oriented normal to the charge current direction.

  19. Solid Propulsion De-Orbiting and Re-Orbiting (United States)

    Schonenborg, R. A. C.; Schoyer, H. F. R.


    With many "innovative" de-orbit systems (e.g. tethers, aero breaking, etc.) and with natural de-orbit, the place of impact of unburned spacecraft debris on Earth can not be determined accurately. The idea that satellites burn up completely upon re-entry is a common misunderstanding. To the best of our knowledge only rocket motors are capable of delivering an impulse that is high enough, to conduct a de-orbit procedure swiftly, hence to de-orbit at a specific moment that allows to predict the impact point of unburned spacecraft debris accurately in remote areas. In addition, swift de-orbiting will reduce the on-orbit time of the 'dead' satellite, which reduces the chance of the dead satellite being hit by other dead or active satellites, while spiralling down to Earth during a slow, 25 year, or more, natural de-orbit process. Furthermore the reduced on-orbit time reduces the chance that spacecraft batteries, propellant tanks or other components blow up and also reduces the time that the object requires tracking from Earth.The use of solid propellant for the de-orbiting of spacecraft is feasible. The main advantages of a solid propellant based system are the relatively high thrust and the facts that the system can be made autonomous quite easily and that the system can be very reliable. The latter is especially desirable when one wants to de-orbit old or 'dead' satellites that might not be able to rely anymore on their primary systems. The disadvantage however, is the addition of an extra system to the spacecraft as well as a (small) mass penalty. [1]This paper describes the above mentioned system and shows as well, why such a system can also be used to re-orbit spacecraft in GEO, at the end of their life to a graveyard orbit.Additionally the system is theoretically compared to an existing system, of which performance data is available.A swift market analysis is performed as well.

  20. Happy Cycling

    DEFF Research Database (Denmark)

    Geert Jensen, Birgitte; Nielsen, Tom


    Artiklens formål er at diskutere oplevede kvaliteter og adfærdsaspekter af mobilitet med udgangspunkt i spørgsmålet om cykling i byer og relationen mellem design og adfærd. Artiklen tager afsæt i et studie forløb der involverede studerende fra Urban Design, Industriel Design Arkitektskolen Aarhus...... og Interaktions Design, Aarhus Universitet under opgave teamet: ”Happy Cycling City – Aarhus”. Udfordringen i studieopgaven var at vise nye attraktive løsningsmuligheder i forhold til cyklens og cyklismens integration i byrum samt at påpege relationen mellem design og overordnede diskussioner af...

  1. Rehabilitation of orbital cavity after orbital exenteration using polymethyl methacrylate orbital prosthesis. (United States)

    Jain, Sumeet; Jain, Parul


    Squamous cell carcinoma of the eyelid is the second most common malignant neoplasm of the eye with the incidence of 0.09 and 2.42 cases/100 000 people. Orbital invasion is a rare complication but, if recognized early, can be treated effectively with exenteration. Although with advancements in technology such as computer-aided design and computer-aided manufacturing, material science, and retentive methods like implants, orbital prosthesis with stock ocular prosthesis made of methyl methacrylate retained by anatomic undercuts is quiet effective and should not be overlooked and forgotten. This clinical report describes prosthetic rehabilitation of two male patients with polymethyl methacrylate resin orbital prosthesis after orbital exenteration, for squamous cell carcinoma of the upper eyelid. The orbital prosthesis was sufficiently retained by hard and soft tissue undercuts without any complications. The patients using the prosthesis are quite satisfied with the cosmetic results and felt comfortable attending the social events.

  2. Rehabilitation of orbital cavity after orbital exenteration using polymethyl methacrylate orbital prosthesis

    Directory of Open Access Journals (Sweden)

    Sumeet Jain


    Full Text Available Squamous cell carcinoma of the eyelid is the second most common malignant neoplasm of the eye with the incidence of 0.09 and 2.42 cases/100 000 people. Orbital invasion is a rare complication but, if recognized early, can be treated effectively with exenteration. Although with advancements in technology such as computer-aided design and computer-aided manufacturing, material science, and retentive methods like implants, orbital prosthesis with stock ocular prosthesis made of methyl methacrylate retained by anatomic undercuts is quiet effective and should not be overlooked and forgotten. This clinical report describes prosthetic rehabilitation of two male patients with polymethyl methacrylate resin orbital prosthesis after orbital exenteration, for squamous cell carcinoma of the upper eyelid. The orbital prosthesis was sufficiently retained by hard and soft tissue undercuts without any complications. The patients using the prosthesis are quite satisfied with the cosmetic results and felt comfortable attending the social events.

  3. Atoms in half-cycle pulses: a laboratory for wavefunction tailoring, coherent control, and quantum chaos (United States)

    Burgdoerfer, Joachim


    The ultimate limit of a short pulse is a half-cycle pulse (HCP) subtending only a fraction of an ``optical cycle''. Single pulses as well as trains of HCP's are currently experimentally accessible in the GHz and THz regimes. In Rydberg atoms the duration of such HCP's is short compared to the electronic orbital period representing an impulsive ``kick''. HCP sequences allow to shape and manipulate the time-dependent wavefunction in an (almost) arbitrary fashion. We illustrate the potential of this tool with a few examples: quantum localization in classical chaos, tayloring of wavepackets with low entropy, and probing the coordinate and momentum of a bound electron. Generation of HCP's on an attosecond scale will be discussed. Work supported by FWF, NSF, and DCS, OBES, U.S. DoE, managed by UT-Batelle LLC under contract #DE-AC05-00OR22725.

  4. Orbital Infarction due to Sickle Cell Disease without Orbital Pain

    Directory of Open Access Journals (Sweden)

    Cameron L. McBride


    Full Text Available Sickle cell disease is a hemoglobinopathy that results in paroxysmal arteriolar occlusion and tissue infarction that can manifest in a plurality of tissues. Rarely, these infarcted crises manifest in the bony orbit. Orbital infarction usually presents with acute onset of periorbital tenderness, swelling, erythema, and pain. Soft tissue swelling can result in proptosis and attenuation of extraocular movements. Expedient diagnosis of sickle cell orbital infarction is crucial because this is a potentially sight-threatening entity. Diagnosis can be delayed since the presentation has physical and radiographic findings mimicking various infectious and traumatic processes. We describe a patient who presented with sickle cell orbital crisis without pain. This case highlights the importance of maintaining a high index of suspicion in patients with known sickle cell disease or of African descent born outside the United States in a region where screening for hemoglobinopathy is not routine, even when the presentation is not classic.

  5. SPHERES Mars Orbiting Sample Return External Orbiting Capture Project (United States)

    National Aeronautics and Space Administration — NASA's Mars Sample Return (MSR) mission scenario utilizes a small Orbiting Sample (OS) satellite, launched from the surface of Mars, which will rendezvous with an...

  6. Safe cycling!

    CERN Document Server

    Anaïs Schaeffer


    The HSE Unit will be running a cycling safety campaign at the entrances to CERN's restaurants on 14, 15 and 16 May. Pop along to see if they can persuade you to get back in the saddle!   With summer on its way, you might feel like getting your bike out of winter storage. Well, the HSE Unit has come up with some original ideas to remind you of some of the most basic safety rules. This year, the prevention campaign will be focussing on three themes: "Cyclists and their equipment", "The bicycle on the road", and "Other road users". This is an opportunity to think about the condition of your bike as well as how you ride it. From 14 to 16 May, representatives of the Swiss Office of Accident Prevention and the Touring Club Suisse will join members of the HSE Unit at the entrances to CERN's restaurants to give you advice on safe cycling (see box). They will also be organising three activity stands where you can test your knowle...

  7. Orbital soft-tissue trauma. (United States)

    Chazen, J Levi; Lantos, Joshua; Gupta, Ajay; Lelli, Gary J; Phillips, C Douglas


    In the clinical assessment of orbital trauma, visual acuity and extraocular muscle motility are critical for rapid evaluation of injury severity. However, assessment of these parameters may be limited by edema and concomitant injuries. Imaging may further delineate the trauma pattern and extent of injury. This review focuses on orbital soft-tissue injuries that can exist with or without orbital fracture. Imaging techniques and soft-tissue injuries, including those involving the anterior chamber, iris and ciliary body, lens, globe, posterior segment, and optic nerve, are reviewed, in addition to intraocular foreign bodies and cavernous-carotid fistulas. Copyright © 2014 Elsevier Inc. All rights reserved.

  8. Comparisons of the CODD and of the Normaliser Systems For Closed Orbit Measurements in the PS

    CERN Document Server

    Belleman, J; Ludwig, M; Potier, J P; Steerenberg, R; CERN. Geneva. AB Department


    The PS ring is equipped with 40 position PUs distributed around the ring. These are connected to the CODD system, which performs trajectory measurements of any single bunch, on two consecutive turns, and to 40 Normalisers, which deliver an averaged orbit. CODD uses a beam-synchronous timing system, which tracks a given bunch all through the acceleration cycle, but needs resynchronization after harmonic changes. It measures at injection or at any given C-timing, albeit with no less than 5ms between acquisitions. It is blind during harmonic changes. A Normaliser, using a technique originally developed for radial loop control, produces a slow signal, proportional to the average position of the bunches. At beam injection a settling time of 1.5ms is needed; then it follows orbit changes with a 200us time constant. Thus, it will not show rapid position changes, such as betatron oscillations. It does not require accurate timing. In the PS installation, the Normaliser outputs are simply sampled at 1ms intervals. CODD...

  9. A Two-Stage-to-Orbit Spaceplane Concept With Growth Potential (United States)

    Mehta, Unmeel B.; Bowles, Jeffrey V.


    A two-stage-to-orbit (TSTO) spaceplane concept developed in 1993 is revisited, and new information is provided to assist in the development of the next-generation space transportation vehicles. The design philosophy, TSTO spaceplane concept, and the design method are briefly described. A trade study between cold and hot structures leads to the choice of cold structures with external thermal protection systems. The optimal Mach number for staging the second stage of the TSTO spaceplane (with air-breathing propulsion on the first stage) is 10, based on life-cycle cost analysis. The performance and specification of a prototype/experimental (P/X) TSTO spaceplane with a turbo/ram/scramjet propulsion system and built-in growth potential are presented and discussed. The internal rate of return on investment is the highest for the proposed TSTO spaceplane, vis-A-vis a single-stage-to-orbit (SSTO) rocket vehicle and a TSTO spaceplane without built-in growth. Additional growth potentials for the proposed spaceplane are suggested. This spaceplane can substantially decrease access-to-space cost and risk, and increase safety and reliability in the near term It can be a serious candidate for the next-generation space transportation system.

  10. OCO-2 (Orbiting Carbon Observatory-2) mission operations planning and initial operations experiences (United States)

    Basilio, Ralph R.; Pollock, H. Randy; Hunyadi-Lay, Sarah L.


    OCO-2 (Orbiting Carbon Observatory-2) is the first NASA (National Aeronautics and Space Administration) mission dedicated to studying atmospheric carbon dioxide, specifically to identify sources (emitters) and sinks (absorbers) on a regional (1000 km x 1000 km) scale. The mission is designed to meet a science imperative by providing critical and urgent measurements needed to improve understanding of the carbon cycle and global climate change processes. The single instrument consisting of three grating spectrometers was built at the Jet Propulsion Laboratory, but is based on the design co-developed with Hamilton Sundstrand Corporation for the original OCO mission. The instrument underwent an extensive ground test program. This was generally made possible through the use of a thermal vacuum chamber with a window/port that allowed optical ground support equipment to stimulate the instrument. The instrument was later delivered to Orbital Sciences Corporation for integration and test with the LEOStar-2 spacecraft. During the overall ground test campaign, proper function and performance in simulated launch, ascent, and space environments were verified. The observatory was launched into space on 02 July 2014. Initial indications are that the instrument is meeting functional and performance specifications, and there is every expectation that the spatially-order, geo-located, calibrated spectra of reflected sunlight and the science retrievals will meet the Level 1 science requirements.

  11. JSC Orbital Debris Website Description (United States)

    Johnson, Nicholas L.


    Purpose: The website provides information about the NASA Orbital Debris Program Office at JSC, which is the lead NASA center for orbital debris research. It is recognized world-wide for its leadership in addressing orbital debris issues. The NASA Orbital Debris Program Office has taken the international lead in conducting measurements of the environment and in developing the technical consensus for adopting mitigation measures to protect users of the orbital environment. Work at the center continues with developing an improved understanding of the orbital debris environment and measures that can be taken to control its growth. Major Contents: Orbital Debris research is divided into the following five broad efforts. Each area of research contains specific information as follows: 1) Modeling - NASA scientists continue to develop and upgrade orbital debris models to describe and characterize the current and future debris environment. Evolutionary and engineering models are described in detail. Downloadable items include a document in PDF format and executable software. 2) Measurements - Measurements of near-Earth orbital debris are accomplished by conducting ground-based and space-based observations of the orbital debris environment. The data from these sources provide validation of the environment models and identify the presence of new sources. Radar, optical and surface examinations are described. External links to related topics are provided. 3) Protection - Orbital debris protection involves conducting hypervelocity impact measurements to assess the risk presented by orbital debris to operating spacecraft and developing new materials and new designs to provide better protection from the environment with less weight penalty. The data from this work provides the link between the environment defined by the models and the risk presented by that environment to operating spacecraft and provides recommendations on design and operations procedures to reduce the risk as

  12. Calculation of injection and extraction orbits for the IPCR SSC

    International Nuclear Information System (INIS)

    Goto, A.; Yano, Y.; Kishida, N.; Nakanishi, N.; Wada, T.


    Calculations of beam trajectories in the injection and extraction systems for the IPCR SSC were done and the characteristics of those elements were determined. Beam centering for single turn extraction by use of first harmonic fields were also studied. The rather simple conditions at the injection point for a well-centered acceleration orbit are also discussed

  13. Elasticity, viscosity, and deformation of orbital fat


    Schoemaker, Ivo; Hoefnagel, Pepijn; Mastenbroek, Tom; Kolff, Cornelis; Schutte, Sander; Helm, Frans; Picken, Stephen; Gerritsen, Anton; Wielopolski, Piotr; Spekreijse, Henk; Simonsz, Huib


    textabstractPURPOSE. For development of a finite element analysis model of orbital mechanics, it was necessary to determine the material properties of orbital fat and its degree of deformation in eye rotation. METHODS. Elasticity and viscosity of orbital fat of eight orbits of four calves and two orbits of one rhesus monkey were measured with a parallel-plate rheometer. The degree of deformation of orbital fat was studied in two human subjects by magnetic resonance imaging (MRI) through the o...

  14. Management of odontogenic orbital cellulitis. (United States)

    DeCroos, F C; Liao, J C; Ramey, N A; Li, I


    This work describes a series of patients with odontogenic orbital cellulitis (OOC), focusing on rate of abscess formation, need for surgical intervention, and imaging findings helpful for rapid diagnosis. Review of a current case and 22 patients with OOC from the scientific literature demonstrated periapical lucency as the most commonly (36.4%) reported finding on facial and orbital computerized tomography (CT) scan. Orbital abscess occurred in 72.7% of cases, and tooth extraction and/or abscess drainage was required in 95.5% of cases reviewed for control of infection. The current case presented with periapical lucency on CT scan, developed orbital abscess despite broad spectrum antibiotic therapy, and required multiple surgical interventions for disease resolution. Though our patient regained excellent vision, OOC often can result in severe vision loss. Periapical lucency on CT can help identify this atypical origin of cellulitis that is strongly associated with abscess formation and need for surgical intervention.

  15. Real and Hybrid Atomic Orbitals. (United States)

    Cook, D. B.; Fowler, P. W.


    Demonstrates that the Schrodinger equation for the hydrogenlike atom separates in both spheroconal and prolate spheroidal coordinates and that these separations provide a sound theoretical basis for the real and hybrid atomic orbitals. (Author/SK)

  16. Lidar Orbital Angular Momentum Sensor (United States)

    National Aeronautics and Space Administration — The recognition in recent decades that electromagnetic fields have angular momentum (AM) in the form of not only polarization (or spin AM) but also orbital (OAM) has...

  17. A Case of Orbital Histoplasmosis. (United States)

    Krakauer, Mark; Prendes, Mark Armando; Wilkes, Byron; Lee, Hui Bae Harold; Fraig, Mostafa; Nunery, William R


    Histoplasma capsulatum var capsulatum is a dimorphic fungus endemic to the Ohio and Mississippi River Valleys of the United States. In this case report, a 33-year-old woman who presented with a right orbital mass causing progressive vision loss, diplopia, and facial swelling is described. Lateral orbitotomy with lateral orbital wall bone flap was performed for excisional biopsy of the lesion. The 1.5 × 1.8 × 2.3 cm cicatricial mass demonstrated a granulomatous lesion with necrosis and positive staining consistent with Histoplasma capsulatum var capsulatum infection. To the authors' knowledge, this is the first case of orbital histoplasmosis to be reported in the United States and the first case worldwide of orbital histoplasmosis due to Histoplasma capsulatum var capsulatum.

  18. NASA Orbital Debris Baseline Populations (United States)

    Krisko, Paula H.; Vavrin, A. B.


    The NASA Orbital Debris Program Office has created high fidelity populations of the debris environment. The populations include objects of 1 cm and larger in Low Earth Orbit through Geosynchronous Transfer Orbit. They were designed for the purpose of assisting debris researchers and sensor developers in planning and testing. This environment is derived directly from the newest ORDEM model populations which include a background derived from LEGEND, as well as specific events such as the Chinese ASAT test, the Iridium 33/Cosmos 2251 accidental collision, the RORSAT sodium-potassium droplet releases, and other miscellaneous events. It is the most realistic ODPO debris population to date. In this paper we present the populations in chart form. We describe derivations of the background population and the specific populations added on. We validate our 1 cm and larger Low Earth Orbit population against SSN, Haystack, and HAX radar measurements.

  19. Impact Effects Calculator. Orbital Parameters. (United States)

    Glazachev, D.; Naroenkov, S.; Kartashova, A.; Turuntaev, I.; Svetsov, V.; Shuvalov, V.; Popova, O.; Podobnaya, E.


    Next-generation Impact Calculator for quick assessment of impact consequences is preparing. The estimates of impact effects are revised. The possibility to manipulate with the orbital parameters and to determine impact point is included.

  20. High Power Orbit Transfer Vehicle

    National Research Council Canada - National Science Library

    Gulczinski, Frank


    ... from Virginia Tech University and Aerophysics, Inc. to examine propulsion requirements for a high-power orbit transfer vehicle using thin-film voltaic solar array technologies under development by the Space Vehicles Directorate (dubbed PowerSail...

  1. Topological photonic orbital-angular-momentum switch (United States)

    Luo, Xi-Wang; Zhang, Chuanwei; Guo, Guang-Can; Zhou, Zheng-Wei


    The large number of available orbital-angular-momentum (OAM) states of photons provides a unique resource for many important applications in quantum information and optical communications. However, conventional OAM switching devices usually rely on precise parameter control and are limited by slow switching rate and low efficiency. Here we propose a robust, fast, and efficient photonic OAM switch device based on a topological process, where photons are adiabatically pumped to a target OAM state on demand. Such topological OAM pumping can be realized through manipulating photons in a few degenerate main cavities and involves only a limited number of optical elements. A large change of OAM at ˜10q can be realized with only q degenerate main cavities and at most 5 q pumping cycles. The topological photonic OAM switch may become a powerful device for broad applications in many different fields and motivate a topological design of conventional optical devices.

  2. Advanced oxygen-hydrocarbon Earth-to-orbit propulsion (United States)

    Obrien, C. J.


    Liquid oxygen/hydrocarbon (LO2/HC) rocket engine cycles for a surface to orbit transportation system were evaluated. A consistent engine system data base is established for defining advantages and disadvantages, system performance and operating limits, engine parametric data, and technology requirements for candidate engine systems. Preliminary comparisons of the engine cycles utilizing delivered specific impulse values are presented. Methane and propane staged combustion cycles are the highest LO2/HC performers. The hydrogen cooled LO2/methane dual throat engine was found to be the highest performing. Technology needs identified in the study include: high temperature turbines; oxidizer-rich preburners; LO2, methane, and propane cooling; methane and propane fuel-rich preburners; the HC fuel turbopump; and application of advanced composite materials to the engine system. Parametric sensitivity analysis data are displayed which show the effect of variations in engine thrust, mixture ratio, chamber pressure, area ratio, cycle life, and turbine inlet temperature on specific impulse and engine weight.

  3. Topological imprint for periodic orbits

    International Nuclear Information System (INIS)

    Martín, Jesús San; Moscoso, Ma José; Gómez, A González


    The more self-crossing points an orbit has the more complex it is. We introduce the topological imprint to characterize crossing points and focus on the period-doubling cascade. The period-doubling cascade topological imprint determines the topological imprint for orbits in chaotic bands. In addition, there is a closer link between this concept and the braids studied by Lettelier et al (2000 J. Phys. A: Math. Gen. 33 1809–25). (paper)

  4. Aquarius L2 Swath Single Orbit Soil Moisture V004 (United States)

    National Aeronautics and Space Administration — This data set contains Level-2 global soil moisture estimates derived from the NASA Aquarius passive microwave radiometer on the Satélite de Aplicaciones Científicas...

  5. The Venus-Earth-Jupiter spin-orbit coupling model (United States)

    Wilson, I. R. G.


    A Venus-Earth-Jupiter spin-orbit coupling model is constructed from a combination of the Venus-Earth-Jupiter tidal-torquing model and the gear effect. The new model produces net tangential torques that act upon the outer convective layers of the Sun with periodicities that match many of the long-term cycles that are found in the 10Be and 14C proxy records of solar activity.

  6. ERS-1/2 orbit improvement using TOPEX/POSEIDON: The 2 cm challenge (United States)

    Le Traon, P.-Y.; Ogor, F.


    The ERS orbit error reduction method using TOPEX/POSEIDON (T/P) data as a reference [Le Traon et al., 1995a] was applied to ERS-1 cycles from phases C, E, F, and G and to the first 16 cycles of the ERS-2 mission (phase A). T/P M-GDR (geophysical data record) (version C) and ERS-1/2 ocean product (OPR) data were used. ERS-1/2 orbits are the D-PAF (processing and archiving facility) orbits and, when necessary, ERS-1/2 altimetric corrections were updated to make the T/P and ERS-1/2 corrections homogeneous. The adjustment method has been refined, and formal error on the estimation is now calculated. The ERS-1/2 orbit error estimation is thus estimated to be precise to within about 2 cm root-mean-square (rms). E-E crossover differences are reduced from 12 to 17 cm to only 6.5 cm rms for all processed cycles. Similarly, the T/P-E crossover differences are reduced from 11 to 14 cm to only 7 cm rms. The adjusted D-PAF orbit error varies between 6 and 12 cm rms. The adjustment has also been performed for the Joint Gravity Model 3(JGM 3) orbits of ERS-I phases C, E, and F. The rms difference between the corrected orbits for the D-PAF and JGM 3 orbits is only about 1 cm rms, while it is about 11 cm before T/P orbit error correction. This shows that the adjustment is almost insensitive to the initial ERS-I orbit used. It also confirms the 2 cm precision of the method. We also do repeat-track analysis on the 35 day repeat cycles of ERS-I phase C. The mean difference in sea level variance before and after orbit error correction is 34 cm2 (D-PAF orbit) and 17 cm2 (JGM 3 orbit). The corrected ERS-1 and T/P sea level variabilities, however, are in excellent agreement. The study thus shows that ERS-1/2 orbit error must be corrected before analyzing large-scale oceanic signals and combining ERS-1/2 with T/P data. The proposed method provides a very effective correction and thus significantly enhances the quality of ERS-1/2 data. Corresponding data sets will be distributed to the

  7. Cycles orbitaux et rythmes d'observation de la Terre

    Directory of Open Access Journals (Sweden)

    Fernand VERGER


    Full Text Available La répétitivité des observations des satellites de télédétection dépend de leur cycle orbital. Les contraintes imposées par un cycle rigide sont assouplies par les capteurs à optique orientable latéralement et par les modifications du cycle au cours de la vie des satellites.

  8. Spacecraft orbit propagator integration with GNSS in a simulated scenario (United States)

    Jing, Shuai; Zhan, Xingqun; Zhu, Zhenghong


    When space vehicles operate above the Global Navigation Satellite System (GNSS) constellation or even above geosynchronous orbit, it is common that the traditional GNSS single-epoch solution can't meet the requirement of orbit determination (OD). To provide the required OD accuracy continuously, a new designed spacecraft orbit propagator (OP) is combined with the GNSS observations in a deep integration mode. Taking both the computational complexity and positioning accuracy into consideration, the orbit propagator is optimized based on a simplified fourth order Runge-Kutta integral aided with empirical acceleration model. A simulation scenario containing a typical Highly-inclined Elliptical Orbit (HEO) user and GPS constellation is established on a HwaCreat™ GNSS signal simulator to testify the performance of the design. The numerical test results show that the maximum propagation error of the optimized orbit propagator does not exceed 1000 m within a day, which is superior to conventional OPs. If the new OP is deeply integrated with GNSS in our proposed scheme, the 95% SEP for the OD accuracy is 10.0005 m, and the time to first fix (TTFF) values under cold and warm start conditions are reduced by at least 7 s and 2 s respectively, which proves its advantage over loose integration and tight integration.

  9. Classification of Tidal Disruption Events Based on Stellar Orbital Properties (United States)

    Hayasaki, Kimitake; Zhong, Shiyan; Li, Shuo; Berczik, Peter; Spurzem, Rainer


    We study the rates of tidal disruption of stars on bound to unbound orbits by intermediate-mass to supermassive black holes using high-accuracy direct N-body experiments. Stars from the star cluster approaching the black hole can have three types of orbit: eccentric, parabolic, and hyperbolic. Since the mass fallback rate shows different variabilities depending on the orbital type, we can classify tidal disruption events (TDEs) into three main categories: eccentric, parabolic, and hyperbolic. The respective TDEs are characterized by two critical values of the orbital eccentricity: the lower critical eccentricity is the one below which stars on eccentric orbits cause finite, intense accretion, and the upper critical eccentricity is the one above which stars on hyperbolic orbits cause no accretion. Moreover, we find that parabolic TDEs can be divided into three subclasses: precisely parabolic, marginally eccentric, and marginally hyperbolic. We analytically derive that the mass fallback rate of marginally eccentric TDEs can be flatter and slightly higher than the standard fallback rate proportional to t ‑5/3, whereas it can be flatter and lower for marginally hyperbolic TDEs. We confirm using N-body experiments that only a few eccentric, precisely parabolic, and hyperbolic TDEs can occur in a spherical stellar system with a single intermediate-mass to supermassive black hole. A substantial fraction of the stars approaching the black hole would cause marginally eccentric or marginally hyperbolic TDEs.

  10. Space Tourism: Orbital Debris Considerations (United States)

    Mahmoudian, N.; Shajiee, S.; Moghani, T.; Bahrami, M.


    Space activities after a phase of research and development, political competition and national prestige have entered an era of real commercialization. Remote sensing, earth observation, and communication are among the areas in which this growing industry is facing competition and declining government money. A project like International Space Station, which draws from public money, has not only opened a window of real multinational cooperation, but also changed space travel from a mere fantasy into a real world activity. Besides research activities for sending man to moon and Mars and other outer planets, space travel has attracted a considerable attention in recent years in the form of space tourism. Four countries from space fairing nations are actively involved in the development of space tourism. Even, nations which are either in early stages of space technology development or just beginning their space activities, have high ambitions in this area. This is worth noting considering their limited resources. At present, trips to space are available, but limited and expensive. To move beyond this point to generally available trips to orbit and week long stays in LEO, in orbital hotels, some of the required basic transportations, living requirements, and technological developments required for long stay in orbit are already underway. For tourism to develop to a real everyday business, not only the price has to come down to meaningful levels, but also safety considerations should be fully developed to attract travelers' trust. A serious hazard to space activities in general and space tourism in particular is space debris in earth orbit. Orbiting debris are man-made objects left over by space operations, hazardous to space missions. Since the higher density of debris population occurs in low earth orbit, which is also the same orbit of interest to space tourism, a careful attention should be paid to the effect of debris on tourism activities. In this study, after a

  11. Rehabilitation of orbital cavity after orbital exenteration using polymethyl methacrylate orbital prosthesis


    Jain, Sumeet; Jain, Parul


    Squamous cell carcinoma of the eyelid is the second most common malignant neoplasm of the eye with the incidence of 0.09 and 2.42 cases/100 000 people. Orbital invasion is a rare complication but, if recognized early, can be treated effectively with exenteration. Although with advancements in technology such as computer-aided design and computer-aided manufacturing, material science, and retentive methods like implants, orbital prosthesis with stock ocular prosthesis made of methyl methacryla...

  12. Your Menstrual Cycle (United States)

    ... during your menstrual cycle What happens during your menstrual cycle The menstrual cycle includes not just your period, but the ... tool is based on a sample 28-day menstrual cycle, but every woman is different in how ...

  13. OrbitMaster: An Online Tool for Investigating Solar System Dynamics and Visualizing Orbital Uncertainties in the Undergraduate Classroom (United States)

    Puckett, Andrew W.; Rector, Travis A.; Baalke, Ron; Ajiki, Osamu


    OrbitMaster is a 3-D orbit visualization tool designed for the undergraduate astronomy classroom. It has been adapted from AstroArts' interactive OrbitViewer applet under the GNU General Public License, as part of the Research-Based Science Education for Undergraduates (RBSEU) curriculum. New features allow the user to alter an asteroid's orbital parameters using slider controls, and to monitor its changing position and speed relative to both Sun and Earth. It detects close approaches and collisions with Earth, and calculates revised distances and impact speeds due to Earth's gravitational attraction. It can also display many asteroid orbits at once, with direct application to visualizing the uncertainty in a single asteroid's orbital parameters. When paired with Project Pluto's Find_Orb orbit determination software and a source of asteroid astrometry, this enables monitoring of changes in orbital uncertainties with time and/or additional observational data. See series of undergraduate labs using the OrbitMaster applet are available as part of the RBSEU curriculum. In the first lab, students gain hands-on experience with the mechanics of asteroid orbits and confirm Kepler's laws of planetary motion. In the second, they study the orbits of Potentially Hazardous Asteroids as they build their own "Killer Asteroids" and investigate the minimum and maximum speed limits that apply to Earth-impacting objects. In the third and fourth labs, they discover the kinetic energy-crater size relationship, engage in their own Crater Scene Investigation (C.S.I.) to estimate impactor size, and understand the regional consequences of impacts. These labs may be used separately, or in support of a further seven-week sequence culminating in an authentic research project in which students submit measurements to the Minor Planet Center to refine a real asteroid's orbit. As with all RBSE projects, the overarching goal is

  14. Microbiology of pediatric orbital cellulitis. (United States)

    McKinley, Steven H; Yen, Michael T; Miller, Aaron M; Yen, Kimberly G


    To evaluate the microbiology of pediatric orbital cellulitis associated with sinusitis. Retrospective review of medical records of pediatric patients treated for orbital cellulitis. All pediatric patients treated for orbital cellulitis associated with sinusitis at Texas Children's Hospital between December 1, 2001 and September 30, 2005 were reviewed. Data collected included patient age, history, microbiology results, and surgical intervention. Thirty-eight cases were identified. Fifteen cases required medical management, whereas 23 patients received a combination of medical and surgical intervention. Three patients had multiple surgical procedures performed. Of the procedures performed, four were sinus irrigation, 12 were sinusotomy and drainage, nine were orbitotomy with drainage of abscess, and one was craniotomy with drainage of abscess. Surgical aspirate specimens yielded a higher positive culture result rate with 9/9 of orbital abscesses and 13/16 of sinus aspirates demonstrating a positive yield. Two of the 27 blood cultures had a positive yield. Staphylococcus species was the most common organism isolated. Methicillin-resistant S. aureus (MRSA) represented 73% of S. aureus isolates. Streptococcus species was the next most common pathogen. Three cultures yielded Haemophilus species with one being positive for H. influenzae. Organisms responsible for causing pediatric orbital cellulitis are evolving, with Staphylococcus followed by Streptococcus species being the most common pathogens. The occurrence of MRSA in pediatric orbital cellulitis is increasing, and empiric antimicrobial therapy should be directed against these organisms if they are prevalent in the community. Sinus and orbital abscess aspirates yielded the greatest number of positive cultures, though these invasive surgical procedures should be performed only when clinically indicated.

  15. Forces charging the orbital floor after orbital trauma. (United States)

    Birkenfeld, Falk; Steiner, Martin; Becker, Merlind Erika; Kern, Matthias; Wiltfang, Jörg; Lucius, Ralph; Becker, Stephan Thomas


    The objectives of this study were (i) to evaluate different fracture mechanisms for orbital floor fractures and (ii) to measure forces and displacement of intraorbital tissue after orbital traumata to predict the necessity of strength for reconstruction materials. Six fresh frozen human heads were used, and orbital floor defects in the right and left orbit were created by a direct impact of 3.0 J onto the globe and infraorbital rim, respectively. Orbital floor defect sizes and displacement were evaluated after a Le Fort I osteotomy. In addition, after reposition of the intraorbital tissue, forces and displacement were measured. The orbital floor defect sizes were 208.3 (SD, 33.4) mm(2) for globe impact and 221.8 (SD, 53.1) mm(2) for infraorbital impact. The intraorbital tissue displacement after the impact and before reposition was 5.6 (SD, 1.0) mm for globe impact and 2.8 (SD, 0.7) mm for infraorbital impact. After reposition, the displacement was 0.8 (SD, 0.5) mm and 1.1 (SD, 0.7) mm, respectively. The measured applied forces were 0.061 (SD, 0.014) N for globe impact and 0.066 (SD, 0.022) N for infraorbital impact. Different fracture-inductive mechanisms are not reflected by the pattern of the fracture. The forces needed after reposition are minimal (~0.07 N), which may explain the success of PDS foils [poly-(p-dioxanone)] and collagen membranes as reconstruction materials.

  16. Multiple-pass trajectories for an aeroassisted orbital transfer vehicle (United States)

    Rehder, J. J.


    This paper investigates the use of multiple-pass trajectories for aeroassisted orbital transfer vehicles (AOTV) as a means of reducing the severe aeroheating environment and the extreme sensitivity to off-nominal trajectory and atmospheric conditions. One-, two-, and three-pass trajectories were calculated for AOTV's with ballistic coefficients ranging from 5 to 150 psf. Compared to the single-pass case, the maximum heat rate was reduced by 30 percent for two passes and 45 percent for three passes, while the maximum acceleration was reduced by 40 percent and 55 percent, respectively. The sensitivity of the trajectories to variations in atmospheric and orbital parameters was not significantly reduced.

  17. Elasticity, viscosity, and deformation of orbital fat

    NARCIS (Netherlands)

    I. Schoemaker (Ivo); P.P.W. Hoefnagel (Pepijn); T.J. Mastenbroek (Tom); C.F. Kolff (Cornelis); S. Schutte (Sander); F.C.T. van der Helm (Frans); S.J. Picken (Stephen); A.F.C. Gerritsen (Anton); P.A. Wielopolski (Piotr); H. Spekreijse (Henk); H.J. Simonsz (Huib)


    textabstractPURPOSE. For development of a finite element analysis model of orbital mechanics, it was necessary to determine the material properties of orbital fat and its degree of deformation in eye rotation. METHODS. Elasticity and viscosity of orbital fat of eight orbits of four calves and two

  18. Understanding Pediatric Bacterial Preseptal and Orbital Cellulitis


    Gonzalez, Mithra O.; Durairaj, Vikram D.


    Pediatric preseptal and orbital cellulitis are infectious disorders that result in periorbital inflammation. Preseptal cellulitis is often associated with breaches in the skin barrier whereas orbital cellulitis is commonly associated with paranasal sinusitis. Orbital cellulitis may be associated with subperiosteal abscess. It is important to distinguish between preseptal from orbital cellulitis. Clinical examination and diagnostic imaging are useful in determining appropriate management. Pati...

  19. Fictitious Supercontinent Cycles (United States)

    Marvin Herndon, J.


    "Supercontinent cycles" or "Wilson cycles" is the idea that before Pangaea there were a series of supercontinents that each formed and then broke apart and separated before colliding again, re-aggregating, and suturing into a new supercontinent in a continuing sequence. I suggest that "supercontinent cycles" are artificial constructs, like planetary orbit epicycles, attempts to describe geological phenomena within the framework of problematic paradigms, namely, planetesimal Earth formation and plate tectonics' mantle convection. The so-called 'standard model of solar system formation' is problematic as it would lead to insufficiently massive planetary cores and necessitates additional ad hoc hypotheses such as the 'frost line' between Mars and Jupiter to explain planetary differences and whole-planet melting to explain core formation from essentially undifferentiated matter. The assumption of mantle convection is crucial for plate tectonics, not only for seafloor spreading, but also for continental movement; continent masses are assumed to ride atop convection cells. In plate tectonics, plate collisions are thought to be the sole mechanism for fold-mountain formation. Indeed, the occurrence of mountain chains characterized by folding which significantly predate the breakup of Pangaea is the primary basis for assuming the existence of supercontinent cycles with their respective periods of ancient mountain-forming plate collisions. Mantle convection is physically impossible. Rayleigh Number justification has been misapplied. The mantle bottom is too dense to float to the surface by thermal expansion. Sometimes attempts are made to obviate the 'bottom heavy' prohibition by adopting the tacit assumption that the mantle behaves as an ideal gas with no viscous losses, i.e., 'adiabatic'. But the mantle is a solid that does not behave as an ideal gas as evidenced by earthquakes occurring at depths as great as 660 km. Absent mantle convection, plate tectonics is not valid

  20. Orbits on bodies of rotation (United States)

    Schröer, H.

    Orbits of small balls on revolutions solid shells are examined. Which velocity is necessary to stay in balance? The angular velocity remains constant. General revolution solid, revolution cone, revolution ellipsoid, ball, paraboloid and hyperboloid are treated. Chapter 1 represents the frictionless case. Chapter 2 deals with the friction case. The transformation from velocity to the belonging orbit height is calculated in chapter 3. In chapter 4 and 5 the macro revolution solids follow (without and with friction)is treated. The assumption of a homogeneous field is not possible here. The radial gravitational field must be used. In the last chapter we have orbits with non constant angular velocity that can be derived with the Lagrange-equations of the second kind in the frictionless case. Here is also possible to view different revolution solids. The book is recommended to all experimental-, theoretical and mathematical physicists. There is an english and a german edition.

  1. Gravity Probe B orbit determination

    International Nuclear Information System (INIS)

    Shestople, P; Ndili, A; Parkinson, B W; Small, H; Hanuschak, G


    The Gravity Probe B (GP-B) satellite was equipped with a pair of redundant Global Positioning System (GPS) receivers used to provide navigation solutions for real-time and post-processed orbit determination (OD), as well as to establish the relation between vehicle time and coordinated universal time. The receivers performed better than the real-time position requirement of 100 m rms per axis. Post-processed solutions indicated an rms position error of 2.5 m and an rms velocity error of 2.2 mm s −1 . Satellite laser ranging measurements provided independent verification of the GPS-derived GP-B orbit. We discuss the modifications and performance of the Trimble Advance Navigation System Vector III GPS receivers. We describe the GP-B precision orbit and detail the OD methodology, including ephemeris errors and the laser ranging measurements. (paper)

  2. The method of coadjoint orbits

    International Nuclear Information System (INIS)

    Delius, G.W.; Van Nieuwenhuizen, P.; Rodgers, V.G.J.


    The method of coadjoint orbits produces for any infinite dimensional Lie (super) algebra A with nontrivial central charge an action for scalar (super) fields which has at least the symmetry A. In this article, the authors try to make this method accessible to a larger audience by analyzing several examples in more detail than in the literature. After working through the Kac-Moody and Virasoro cases, we apply the method to the super Virasoro algebra and reobtain the super-symmetric extension of Polyakov's local nonpolynomial action for two-dimensional quantum gravity. As in the Virasoro case this action corresponds to the coadjoint orbit of a pure central extension. The authors further consider the actions corresponding to the other orbits of the super Virasoro algebra. As a new result the authors construct the actions for the N = 2 super Virasoro algebra

  3. Low-Thrust Transfers from Distant Retrograde Orbits to L2 Halo Orbits in the Earth-Moon System (United States)

    Parrish, Nathan L.; Parker, Jeffrey S.; Hughes, Steven P.; Heiligers, Jennette


    Enable future missions Any mission to a DRO or halo orbit could benefit from the capability to transfer between these orbits Chemical propulsion could be used for these transfers, but at high propellant cost Fill gaps in knowledge A variety of transfers using SEP or solar sails have been studied for the Earth-Moon system Most results in literature study a single transfer This is a step toward understanding the wide array of types of transfers available in an N-body force model.

  4. Orbit fitting based on Helmert transformation


    Jun Chen; J. Wang


    Orbit fitting is used in many GPS applications. For example, in Precise Point Positioning (PPP), GPS orbits (SP3 orbits) are normally retrieved either from IGS or from one of its Analysis Centers (ACs) with 15 minutes’ sampling, which is much bigger than the normal observation sampling. Therefore, algorithms should be derived to fit GPS orbits to the observation time. Many methods based on interpolation were developed. Using these methods the orbits fit well at the sampling points. However, t...

  5. Autonomous Control System for Precise Orbit Maintenance


    Aorpimai, Manop; Hashida, Yoshi; Palmer, Phil


    In this paper, we describe a closed-loop autonomous control system that enables orbit operations to be performed without the need of any ground segment. The growing availability of GPS receivers on satellites provides an excellent means for autonomous orbit determination and our work builds upon previous work on orbit determination algorithms developed here at Surrey. The orbit is described using a set of epicycle parameters which provide an analytic model of LEO orbits. The parameters in thi...

  6. Theory of orbital magnetoelectric response

    International Nuclear Information System (INIS)

    Malashevich, Andrei; Souza, Ivo; Coh, Sinisa; Vanderbilt, David


    We extend the recently developed theory of bulk orbital magnetization to finite electric fields, and use it to calculate the orbital magnetoelectric (ME) response of periodic insulators. Working in the independent-particle framework, we find that the finite-field orbital magnetization can be written as a sum of three gauge-invariant contributions, one of which has no counterpart at zero field. The extra contribution is collinear with and explicitly dependent on the electric field. The expression for the orbital magnetization is suitable for first-principles implementations, allowing one to calculate the ME response coefficients by numerical differentiation. Alternatively, perturbation-theory techniques may be used, and for that purpose we derive an expression directly for the linear ME tensor by taking the first field-derivative analytically. Two types of terms are obtained. One, the 'Chern-Simons' term, depends only on the unperturbed occupied orbitals and is purely isotropic. The other, 'Kubo' terms, involve the first-order change in the orbitals and give isotropic as well as anisotropic contributions to the response. In ordinary ME insulators all terms are generally present, while in strong Z 2 topological insulators only the Chern-Simons term is allowed, and is quantized. In order to validate the theory, we have calculated under periodic boundary conditions the linear ME susceptibility for a 3D tight-binding model of an ordinary ME insulator, using both the finite-field and perturbation-theory expressions. The results are in excellent agreement with calculations on bounded samples.

  7. Orbital Evolution and Orbital Phase Resolved Spectroscopy of the ...

    Indian Academy of Sciences (India)

    Abstract. We report here results from detailed timing and spectral studies of the high mass X-ray binary pulsar 4U 1538–52 over several binary peri- ods using observations made with the Rossi X-ray Timing Explorer (RXTE) and BeppoSAX satellites. Pulse timing analysis with the 2003 RXTE data over two binary orbits ...

  8. Assessing Terra Disposal Orbit Candidates from an Orbital Debris Perspective (United States)

    Abraham, Andrew J.; Thompson, Roger C.; Mantziaras, Dimitrios C.


    The NASA Terra satellite is reaching the end of its mission life. Because the satellite resides in the 705 km Earth Science Constellation, disposal strategies need to be considered to remove it from this densely populated operational orbit. Of critical importance was the need to examine the future potential risk to other satellite residents of the 705 km constellation due to an unexpected breakup event of the Terra satellite post-disposal. This study quantifies the comparative risk of debris impacts associated with the two leading candidate disposal orbits (701 km vs. 686 km) and characterizes the suitability of each orbit for the purpose of long-term spacecraft disposal. The increase in collision risk to any member of the 705 km Earth Science Constellation is very modest. The long-term, average, total risk (including the ambient background risk) due to a Terra breakup at a disposal of -19 km (i.e., 686 km) relative to the 705 km constellation is 9.7 × 10(exp -6) impacts/day versus 1.0 × 10(exp -5) impacts/day for a disposal of only -4 km (i.e., 701 km). For perspective, note that the nominal space background risk to the 705 km constellation is 9.2 × 10(exp -6) impacts/day which implies a very modest increase in risk (approximately 3% difference between the two cases) due to a Terra breakup in either disposal orbit.

  9. Orbital atherectomy for treating de novo, severely calcified coronary lesions: 3-year results of the pivotal ORBIT II trial. (United States)

    Lee, Michael; Généreux, Philippe; Shlofmitz, Richard; Phillipson, Daniel; Anose, Bynthia M; Martinsen, Brad J; Himmelstein, Stevan I; Chambers, Jeff W


    The presence of heavy coronary artery calcification increases the complexity of percutaneous coronary intervention (PCI) and increases the incidence of major adverse cardiac events (MACE): death, myocardial infarction (MI), target vessel revascularization (TVR), and stent thrombosis. The ORBIT II (Evaluate the Safety and Efficacy of OAS in Treating Severely Calcified Coronary Lesions) trial reported low rates of procedural, 30-day, 1-year, and 2-year ischemic complications after treatment of de novo, severely calcified lesions with the Diamondback 360° Coronary Orbital Atherectomy System (OAS) (Cardiovascular Systems, Inc.). ORBIT II was a single-arm trial that enrolled 443 patients at 49U.S. sites; in this study, de novo, severely calcified coronary lesions were treated with OAS prior to stenting. The primary safety endpoint was 30-day MACE: the composite of cardiac death, MI, and TVR (inclusive of target lesion revascularization (TLR)). The primary efficacy endpoint was procedural success: stent delivery with a residual stenosis of final, 3-year follow-up results from ORBIT II. The majority of subjects (88.2%) underwent PCI with drug-eluting stents after orbital atherectomy. There were 360 (81.3%) subjects who completed the protocol-mandated 3-year visit.The overall cumulative rate of 3-year MACE was 23.5%, including cardiac death (6.7%), MI (11.2%), and TVR (10.2%). The 3-year target lesion revascularization rate was 7.8%. In the final 3-year analysis of the ORBIT II trial, orbital atherectomy of severely calcified coronary lesions followed by stenting resulted in a low rate of adverse ischemic events compared with historical controls.Orbital atherectomy represents a safe and effective revascularization strategy for patients with severely calcified coronary lesions. The ORBIT II trial enrolled 443 subjects to study orbital atherectomy followed by stenting for de novo severely calcified coronary lesions. The overall cumulative 3-year MACE rate was 23

  10. Orbital resonances around black holes. (United States)

    Brink, Jeandrew; Geyer, Marisa; Hinderer, Tanja


    We compute the length and time scales associated with resonant orbits around Kerr black holes for all orbital and spin parameters. Resonance-induced effects are potentially observable when the Event Horizon Telescope resolves the inner structure of Sgr A*, when space-based gravitational wave detectors record phase shifts in the waveform during the resonant passage of a compact object spiraling into the black hole, or in the frequencies of quasiperiodic oscillations for accreting black holes. The onset of geodesic chaos for non-Kerr spacetimes should occur at the resonance locations quantified here.

  11. AA, closed orbit observation pickup

    CERN Multimedia

    CERN PhotoLab


    Electrostatic pickups around the circumference of the AA served for the measurement of the closed orbits across the wide momentum range of +- 3% to either side of central orbit. The pickups were of the "shoebox" type, with diagonal cuts, a horizontal and a vertical one mechanically coupled together. They were located where they would not require extra space. The wide ones (very wide indeed: 70 cm), like the one we see here, were placed inside the vacuum chamber of the wide quadrupoles QFW, at maximum dispersion. See also 8001372, 8001383, 8010045

  12. AA, closed orbit observation pickup

    CERN Multimedia

    CERN PhotoLab


    Electrostatic pickups around the circumference of the AA served for the measurement of the closed orbits across the wide momentum range of +- 3% to either side of central orbit. The pickups were of the "shoebox" type, with diagonal cuts, a horizontal and a vertical one mechanically coupled together. They were located where they would not require extra space. The wide ones (very wide indeed: 70 cm), like the one we see here, were placed inside the vacuum chamber of the wide quadrupoles, QFW, at maximum dispersion. See also 8001372,8001383, 8010042

  13. AA, closed orbit observation pickup

    CERN Multimedia


    Electrostatic pickups around the circumference of the AA served for the measurement of the closed orbits across the wide momentum range of +- 3% to either side of central orbit. The pickups were of the "shoebox" type, with diagonal cuts, a horizontal and a vertical one mechanically coupled together. They were located where they would not require extra space. The small ones, like the one we see here, were inserted into the vacuum chamber of the BLG (long and narrow) bending magnets. See also 8001372, 8010042, 8010045

  14. AA, closed orbit observation pickup

    CERN Multimedia

    CERN PhotoLab


    Electrostatic pickups around the circumference of the AA served for the measurement of the closed orbits across the wide momentum range of +- 3% to either side of central orbit. The pickups were of the "shoebox" type, with diagonal cuts, a horizontal and a vertical one mechanically coupled together. They were located where they would not require extra space. The small ones, like the one we see here, were inserted into the vacuum chamber of the BLG (long and narrow) bending magnets. Werner Sax contemplates his achievement. See also 8001383, 8010042, 8010045.

  15. Energy and the Elliptical Orbit (United States)

    Nettles, Bill


    In the January 2007 issue of The Physics Teacher, Prentis, Fulton, Hesse, and Mazzino describe a laboratory exercise in which students use a geometrical analysis inspired by Newton to show that an elliptical orbit and an inverse-square law force go hand in hand. The historical, geometrical, and teamwork aspects of the exercise are useful and important. This paper presents an exercise which uses an energy/angular momentum conservation model for elliptical orbits. This exercise can be done easily by an individual student and on regular notebook-sized paper.

  16. Primary orbital squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Ana L. Campos Arbulú


    Full Text Available Primary orbital squamous cell carcinoma is a rare entity. There is little published literature. We report a case of primary squamous cell carcinoma of the orbital soft tissues. Surgical resection offered the best treatment for the patient. Complete resection of the lesion was achieved. The patient received adjuvant radiotherapy due to the proximity of the lesion to the surgical margins. Surgical treatment is feasible and should be considered as part of the surgeon's arsenal. However, therapeutic decisions must be made on a case-by-case basis

  17. Orbital physics in sulfur spinels: ordered, liquid and glassy ground states

    International Nuclear Information System (INIS)

    Buettgen, N; Hemberger, J; Fritsch, V; Krimmel, A; Muecksch, M; Nidda, H-A Krug von; Lunkenheimer, P; Fichtl, R; Tsurkan, V; Loidl, A


    Measurements of magnetization M(T, H), heat capacity C(T), NMR lineshift K(T) and linewidth Δ(T), neutron scattering S(Q, ω, T) and broadband dielectric spectroscopy ε(ω, T) provide experimental evidence of the different orbital ground states in the cubic sulfur spinels under investigation. In all compounds, the tetrahedrally coordinated Jahn-Teller ions Fe 2+ are characterized by a degeneracy of the orbital degrees of freedom. Particularly, we found a long-range orbital ordering in polycrystalline (PC) FeCr 2 S 4 , and a glassy freezing of the orbital degrees of freedom in FeCr 2 S 4 (single crystals) (SCs). In contrast, FeSc 2 S 4 belongs to the rare class of spin-orbital liquids, where quantum fluctuations accompanying the glassy freezing of the orbitals suppress long-range magnetic order

  18. A rare case of orbital granulomatous inflammation from explosive hydraulic oil masquerading as orbital cellulitis. (United States)

    Cheema, Marvi; Roelofs, Kelsey; Jivraj, Imran; West, Robert; Rasmussen, Steve; Chan, Audrey


    The differential diagnosis for acute orbital inflammation is broad. We report a case of granulomatous orbital inflammation due to high-pressure oil injury to the orbit presenting as an atypical orbital cellulitis. Here we review the presentation and treatment of orbital inflammation from oil.

  19. Imaging experiment: The Viking Mars orbiter (United States)

    Carr, M.H.; Baum, W.A.; Briggs, G.A.; Masursky, H.; Wise, D.W.; Montgomery, D.R.


    The general objectives of the Imaging Experiment on the Viking Orbiter are to aid the selection of Viking Lander sites, to map and monitor the chosen sites during lander operations, to aid in the selection of future landing sites, and to extend our knowledge of the planet. The imaging system consists of two identical vidicon cameras each attached to a 1026 mm T/8 telescope giving approximately 1?? square field of view. From an altitude of 1500 km the picture elements will be approximately 24m apart. The vidicon is coupled with an image intensifier which provides increased sensitivity and permits electronic shuttering and image motion compensation. A vidicon readout time of 2.24 sec enables pictures to be taken in rapid sequence for contiguous coverage at high resolution. The camera differs from those previously flown to Mars by providing contiguous coverage at high resolution on a single orbital pass, by having sufficient sensitivity to use narrow band color filters at maximum resolution, and by having response in the ultraviolet. These capabilities will be utelized to supplement lander observations and to extend our knowledge particularly of volcanic, erosional, and atmospheric phenomena on Mars. ?? 1972.

  20. Multiple orbital angular momentum generated by dielectric hybrid phase element (United States)

    Wang, Xuewen; Kuchmizhak, Aleksandr; Hu, Dejiao; Li, Xiangping


    Vortex beam carrying multiple orbital angular momentum provides a new degree of freedom to manipulate light leading to the various exciting applications as trapping, quantum optics, information multiplexing, etc. Helical wavefront can be generated either via the geometric or the dynamic phase arising from a space-variant birefringence (q-plate) or from phase accumulation through propagation (spiral-phase-plate), respectively. Using fast direct laser writing technique we fabricate and characterize novel hybrid q-plate generating vortex beam simultaneously carrying two different high-order topological charges, which arise from the spin-orbital conversion and the azimuthal height variation of the recorded structures. We approve the versatile concept to generate multiple-OAM vortex beams combining the spin-orbital interaction and the phase accumulation in a single micro-scale device, a hybrid dielectric phase plate.

  1. Circumlunar Free-Return Cycler Orbits for a Manned Earth-Moon Space Station (United States)

    Genova, Anthony L.; Aldrin, Buzz


    Multiple free-return circumlunar cycler orbits were designed to allow regular travel between the Earth and Moon by a manned space station. The presented cycler orbits contain circumlunar free-return "figure-8" segments and yield lunar encounters every month. Smaller space "taxi" vehicles can rendezvous with (and depart from) the cycling Earth-Moon space station to enter lunar orbit (and/or land on the lunar surface), return to Earth, or reach destinations including Earth-Moon L1 and L2 halo orbits, near-Earth objects (NEOs), Venus, and Mars. To assess the practicality of the selected orbits, relevant cycler characteristics (including (Delta)V maintenance requirements) are presented and compared.

  2. A Free-Return Earth-Moon Cycler Orbit for an Interplanetary Cruise Ship (United States)

    Genova, Anthony L.; Aldrin, Buzz


    A periodic circumlunar orbit is presented that can be used by an interplanetary cruise ship for regular travel between Earth and the Moon. This Earth-Moon cycler orbit was revealed by introducing solar gravity and modest phasing maneuvers (average of 39 m/s per month) which yields close-Earth encounters every 7 or 10 days. Lunar encounters occur every 26 days and offer the chance for a smaller craft to depart the cycler and enter lunar orbit, or head for a Lagrange point (e.g., EM-L2 halo orbit), distant retrograde orbit (DRO), or interplanetary destination such as a near-Earth object (NEO) or Mars. Additionally, return-to-Earth abort options are available from many points along the cycling trajectory.

  3. The glacial cycles and cosmic rays

    CERN Document Server

    Kirkby, Jasper; Müller, R A


    The cause of the glacial cycles remains a mystery. The origin is widely accepted to be astronomical since paleoclimatic archives contain strong spectral components that match the frequencies of Earth's orbital modulation. Milankovitch insolation theory contains similar frequencies and has become established as the standard model of the glacial cycles. However, high precision paleoclimatic data have revealed serious discrepancies with the Milankovitch model that fundamentally challenge its validity and re-open the question of what causes the glacial cycles. We propose here that the ice ages are initially driven not by insolation cycles but by cosmic ray changes, probably through their effect on clouds. This conclusion is based on a wide range of evidence, including results presented here on speleothem growth in caves in Austria and Oman, and on a record of cosmic ray flux over the past 220 kyr obtained from the 10Be composition of deep-ocean sediments.

  4. Characterizing Longitude-Dependent Orbital Debris Congestion in the Geosynchronous Orbit Regime (United States)

    Anderson, Paul V.

    The geosynchronous orbit (GEO) is a unique commodity of the satellite industry that is becoming increasingly contaminated with orbital debris, but is heavily populated with high-value assets from the civil, commercial, and defense sectors. The GEO arena is home to hundreds of communications, data transmission, and intelligence satellites collectively insured for an estimated 18.3 billion USD. As the lack of natural cleansing mechanisms at the GEO altitude renders the lifetimes of GEO debris essentially infinite, conjunction and risk assessment must be performed to safeguard operational assets from debris collisions. In this thesis, longitude-dependent debris congestion is characterized by predicting the number of near-miss events per day for every longitude slot at GEO, using custom debris propagation tools and a torus intersection metric. Near-miss events with the present-day debris population are assigned risk levels based on GEO-relative position and speed, and this risk information is used to prioritize the population for debris removal target selection. Long-term projections of debris growth under nominal launch traffic, mitigation practices, and fragmentation events are also discussed, and latitudinal synchronization of the GEO debris population is explained via node variations arising from luni-solar gravity. In addition to characterizing localized debris congestion in the GEO ring, this thesis further investigates the conjunction risk to operational satellites or debris removal systems applying low-thrust propulsion to raise orbit altitude at end-of-life to a super-synchronous disposal orbit. Conjunction risks as a function of thrust level, miss distance, longitude, and semi-major axis are evaluated, and a guidance method for evading conjuncting debris with continuous thrust by means of a thrust heading change via single-shooting is developed.

  5. WINCS on-orbit performance results (United States)

    Nicholas, Andrew C.; Herrero, Fred A.; Stephan, Andrew W.; Finne, Theodore


    The Winds-Ions-Neutral Composition Suite (WINCS) instrument, also known as the Small Wind and Temperature Spectrometer (SWATS), was designed and developed jointly by the Naval Research Laboratory (NRL) and NASA/Goddard Space Flight Center (GSFC) for ionosphere-thermosphere investigations in orbit between 120 and 550 km altitude. The WINCS instrument houses four spectrometers in a single package with size, weight, and power compatible with a CubeSat. These spectrometers provide the following measurements: neutral winds, neutral temperature, neutral density, neutral composition, ion drifts, ion temperature, ion density and ion composition. The instrument is currently operating on the International Space Station and on the STP-Sat3 spacecraft. Data from the Ion-Drift Temperature-Spectrometer (IDTS) are used to compute the ion drift, temperature, and density in the presence of large changes in spacecraft potential. A summary is given of future flight manifests.

  6. BWROPT: A multi-cycle BWR fuel cycle optimization code

    Energy Technology Data Exchange (ETDEWEB)

    Ottinger, Keith E.; Maldonado, G. Ivan, E-mail:


    Highlights: • A multi-cycle BWR fuel cycle optimization algorithm is presented. • New fuel inventory and core loading pattern determination. • The parallel simulated annealing algorithm was used for the optimization. • Variable sampling probabilities were compared to constant sampling probabilities. - Abstract: A new computer code for performing BWR in-core and out-of-core fuel cycle optimization for multiple cycles simultaneously has been developed. Parallel simulated annealing (PSA) is used to optimize the new fuel inventory and placement of new and reload fuel for each cycle considered. Several algorithm improvements were implemented and evaluated. The most significant of these are variable sampling probabilities and sampling new fuel types from an ordered array. A heuristic control rod pattern (CRP) search algorithm was also implemented, which is useful for single CRP determinations, however, this feature requires significant computational resources and is currently not practical for use in a full multi-cycle optimization. The PSA algorithm was demonstrated to be capable of significant objective function reduction and finding candidate loading patterns without constraint violations. The use of variable sampling probabilities was shown to reduce runtime while producing better results compared to using constant sampling probabilities. Sampling new fuel types from an ordered array was shown to have a mixed effect compared to random new fuel type sampling, whereby using both random and ordered sampling produced better results but required longer runtimes.

  7. KOH concentration effect on cycle life of nickel-hydrogen cells. III - Cycle life test (United States)

    Lim, H. S.; Verzwyvelt, S. A.


    A cycle life test of Ni/H2 cells containing electrolytes of various KOH concentrations and a sintered type nickel electrode was carried out at 23 C using a 45 min accelerated low earth orbit (LEO) cycle regime at 80 percent depth of discharge. One of three cells containing 26 percent KOH has achieved over 28,000 cycles, and the other two 19,000 cycles, without a sign of failure. Two other cells containing 31 percent KOH electrolyte, which is the concentration presently used in aerospace cells, failed after 2,979 and 3,620 cycles. This result indicates that the cycle life of the present type of Ni/H2 cells may be extended by a factor of 5 to 10 simply by lowering the KOH concentration. Long cycle life of a Ni/H2 battery at high depth-of-discharge operation is desired, particularly for an LEO spacecraft application. Typically, battery life of about 30,000 cycles is required for a five year mission in an LEO. Such a cycle life with presently available cells can be assured only at a very low depth-of-discharge operation. Results of testing already show that the cycle life of an Ni/H2 cell is tremendously improved by simply using an electrolyte of low KOH concentration.

  8. Orbital meningioma, the Utrecht experience

    NARCIS (Netherlands)

    Mourits, Maarten Ph.; Berkelbach van der Sprenkel, Jan Willem


    AIMS. 1) To evaluate epidemiological data (age, gender, initial complaints, and ophthalmic findings) of a patient cohort with a primary or secondary orbital meningioma. 2) To evaluate the clinical course of these patients. 3) To evaluate the outcome of treatment. PATIENTS AND METHODS. All


    African Journals Online (AJOL)

    Plastic and Reconstructive Surgery Unit, National Orthopaedic Hospital, Enugu, Nigeria. ABSTRAC"H". Congenital orbital teratomas are rare. This is a case report of an otherwise .... aspirate showed fairly cloudy, blood-tinged straw- coloured fluid with no malignant cells or organisms. Two histopathology reports of 3cm/ ...

  10. On orbit-reflexive operators

    Czech Academy of Sciences Publication Activity Database

    Müller, Vladimír; Vršovský, Jan


    Roč. 79, č. 2 (2009), s. 497-510 ISSN 0024-6107 Institutional research plan: CEZ:AV0Z10190503 Keywords : reflexive operators * orbit-reflexivity Subject RIV: BA - General Mathematics Impact factor: 0.798, year: 2009

  11. Orbital abscess: Management and outcome

    Directory of Open Access Journals (Sweden)

    N Suneetha


    Full Text Available Purpose: To discuss the diagnosis, management and outcome of various types of orbital abscess. Methods: The medical records of 13 patients diagnosed and treated for orbital abscess were reviewed. The sources of infection included: paranasal sinusitis (n = 5, odontogenic origin of infection (n = 4, one each, temporal fossa abscess, palatal abscess, furuncle on the nose, and secondary to retrobulbar injection of steroid. Computed tomographic scans revealed the presence of an abscess in all 13 cases. Associated findings on CT scan included: sinus disease (n = 8, cavernous sinus thrombosis (n = 2 and subdural empyema (n = 2. All patients were treated with intensive, multiple, intravenous antibiotics and early surgical drainage. Results: Purulent material collected surgically from the orbit cultured Staphylococcus aureus (n = 3, two each Pseudomonas aeruginosa, Proteus mirabilis, Acinetobacter species and one each β-haemolytic Streptococci, Citrobacter frundi and Enterobacter. Final visual acuity was good in 6 patients (6/12 - 6/6 and no light perception in 6 others. Visual acuity could not be recorded in the infant. The other complications were intracranial abscess (n = 4, cavernous sinus thrombosis (n = 2 and restricted ocular motility (n = 1. Conclusions: A high index of suspicion is necessary, along with early institution of appropriate diagnostic imaging, and aggressive medical and surgical treatment for a favourable outcome in cases of orbital abscess.

  12. Orbital computed tomography: technical aspects

    International Nuclear Information System (INIS)

    Beck, T.J.; Rosenbaum, A.E.; Miller, N.R.


    Computed tomographic scanning has revolutionized the diagnosis and management of orbital disease. The best use of this methodology requires knowledge of the principles and appropriate attention to scanning protocols. Computed tomographic scanning of the orbit is a demanding technique requiring thin sections through planes precisely positioned from the topographical anatomy. Ideally, orbital CT should include both transverse axial and coronal sections: The pathological condition and its plane of growth will influence the selection of the optimal plane or section. Coronal sections may be obtained either directly or indirectly by computer reconstruction from contiguous transverse images. Sagittal or oblique sections or both also are useful and may be obtained directly or indirectly. Difficulty in patient positioning may preclude direct sagittal imaging, however. The use of intravenous contrast enhancement is not necessary as a routine technique unless a mass is identified or suspected. Where surgical resection or biopsy of a space-occupying lesion is contemplated, contrast enhancement can be valuable in assessing relative vascularity and aiding diagnostic specificity. It should be continually emphasized that CT is a powerful technology which, in orbital diagnosis, produces the highest yield when clinician and radiologist collaborate in the radiodiagnostic workup. The clinical information supplied by the referring ophthalmologist is used by the radiologist both in the selection of the appropriate techniques for investigation and in striving to achieve the most specific conclusion

  13. Orbital rhabdomyosarcoma: multidisciplinary treatment experience. (United States)

    Forstner, D; Borg, M; Saxon, B


    Orbital rhabdomyosarcoma (RMS) accounts for 10% of childhood RMS and has a relatively good prognosis of up to 85% 5-year survival. Improved survival has led to increased interest in late effects of treatment. The objective of this study was to review the results of treating orbital RMS with multidisciplinary treatment at Women's and Children's Hospital and Royal Adelaide Hospital with emphasis on late effects of treatment. A retrospective review was carried out of all patients with orbital RMS treated with multidisciplinary treatment including radiation therapy and chemotherapy in the two institutions between 1982 and 2002. A total of five patients (age range 5.5-12 years) satisfied the eligibility requirements. Late effects were significant and included facial bone hypoplasia, cataract formation and growth hormone deficiency. Overall survival was 80% (4/5) with mean follow up of 8 years (range 3-13 years). Given the high cure rates achieved, future treatments must aim to maintain the good results but to reduce the high incidence of late effects of treatment. Standardised rating of late toxicity, long-term follow-up clinics, and implementation of modern radiation techniques (3-D conformal radiotherapy, intensity modulated radiotherapy, proton therapy) for patients with orbital RMS are important to improving outcome.

  14. Energy and the Elliptical Orbit (United States)

    Nettles, Bill


    In the January 2007 issue of "The Physics Teacher," Prentis, Fulton, Hesse, and Mazzino describe a laboratory exercise in which students use a geometrical analysis inspired by Newton to show that an elliptical orbit and an inverse-square law force go hand in hand. The historical, geometrical, and teamwork aspects of the exercise are useful and…

  15. Getting a Crew into Orbit (United States)

    Riddle, Bob


    Despite the temporary setback in our country's crewed space exploration program, there will continue to be missions requiring crews to orbit Earth and beyond. Under the NASA Authorization Act of 2010, NASA should have its own heavy launch rocket and crew vehicle developed by 2016. Private companies will continue to explore space, as well. At the…

  16. DOT strategies versus orbiter strategies

    NARCIS (Netherlands)

    Rutten, R.J.


    The Dutch Open Telescope is a high-resolution solar imager coming on-line at La Palma. The definition of the DOT science niche, strategies, and requirements resemble Solar Orbiter considerations and deliberations. I discuss the latter in the light of the former, and claim that multi-line observation

  17. Orbitally excited charm - strange mesons

    Energy Technology Data Exchange (ETDEWEB)

    Kasper, Penelope A. [Illinois Inst. of Technology, Chicago, IL (United States)


    This thesis describes an attempt to measure the properties of mesons containing a charm quark and a strange quark in a state of orbital angular momentum L > 0, and compare these with the predictions of theoretical models based on heavy quark effective theory.

  18. Nickel metal hydride LEO cycle testing (United States)

    Lowery, Eric


    The George C. Marshall Space Flight Center is working to characterize aerospace AB5 Nickel Metal Hydride (NiMH) cells. The cells are being evaluated in terms of storage, low earth orbit (LEO) cycling, and response to parametric testing (high rate charge and discharge, charge retention, pulse current ability, etc.). Cells manufactured by Eagle Picher are the subjects of the evaluation. There is speculation that NiMH cells may become direct replacements for current Nickel Cadmium cells in the near future.

  19. Orbital roof encephalocele mimicking a destructive neoplasm. (United States)

    Alsuhaibani, Adel H; Hitchon, Patrick W; Smoker, Wendy R K; Lee, Andrew G; Nerad, Jeffrey A


    The purpose of this case report is to report an orbital roof encephalocele mimicking a destructive orbital neoplasm. Orbital roof encephalocele is uncommon but can mimic neoplasm. One potential mechanism for the orbital roof destruction is a post-traumatic "growing orbital roof fracture." The growing fracture has been reported mostly in children but can occur in adults. Alternative potential etiologies for the encephalocele are discussed, including Gorham syndrome. Orbital roof encephalocele is uncommon in adults, and the findings can superficially resemble an orbital neoplasm. Radiographic and clinical features that might suggest the correct diagnosis include a prior history of trauma, overlying frontal lobe encephalomalacia without significant mass effect or edema, and an orbital roof defect. The "growing fracture" mechanism may be a potential explanation for the orbital roof destruction in some cases.

  20. Capture of particles from plunge orbits by a black hole

    International Nuclear Information System (INIS)

    Young, P.J.


    Photon and ''parabolic'' particle orbits around a Kerr-Newman black hole are considered, both for uncharged particles moving along geodesics and for charged particles under the influence of the Lorentz force (neglecting radiative processes). Investigation of the radial equation of motion gives conditions under which a photon or particle is captured from a ''plunge'' orbit when incident from a large distance; the cross sections and accreted angular momenta are calculated for various fluxes of particles incident on the black hole. For example, the cross section of an extreme Kerr (a = 1) black hole to an isotropic flux of particles is 0.90 of that for a Schwarzschild hole, and the accreted angular momentum per unit mass of swallowed flux is -0.828 leading to rapid spin-down of the hole. The periastra of ''escape'' orbits are considered, and also the minimum periastron corresponding to the unstable spherical orbit that divides plunge and escape orbits. The evolution of the spin and charge of a black hole accreting particles and photons is discussed, including that of primordial black holes. It is shown that such black holes may be of the Schwarzschild type having spun-down due to consumption of radiation and particles at early times and subsequent neutralization in an ionized intergalactic medium. The statistics of proton and electron capture by the smallest surviving primordial black holes, M = 10 15 g, suggests that they are most likely to be found possessing a single quantum of positive charge

  1. Space Shuttle Orbiter-Illustration (United States)


    This illustration is an orbiter cutaway view with callouts. The orbiter is both the brains and heart of the Space Transportation System (STS). About the same size and weight as a DC-9 aircraft, the orbiter contains the pressurized crew compartment (which can normally carry up to seven crew members), the huge cargo bay, and the three main engines mounted on its aft end. There are three levels to the crew cabin. Uppermost is the flight deck where the commander and the pilot control the mission. The middeck is where the gallery, toilet, sleep stations, and storage and experiment lockers are found for the basic needs of weightless daily living. Also located in the middeck is the airlock hatch into the cargo bay and space beyond. It is through this hatch and airlock that astronauts go to don their spacesuits and marned maneuvering units in preparation for extravehicular activities, more popularly known as spacewalks. The Space Shuttle's cargo bay is adaptable to hundreds of tasks. Large enough to accommodate a tour bus (60 x 15 feet or 18.3 x 4.6 meters), the cargo bay carries satellites, spacecraft, and spacelab scientific laboratories to and from Earth orbit. It is also a work station for astronauts to repair satellites, a foundation from which to erect space structures, and a hold for retrieved satellites to be returned to Earth. Thermal tile insulation and blankets (also known as the thermal protection system or TPS) cover the underbelly, bottom of the wings, and other heat-bearing surfaces of the orbiter to protect it during its fiery reentry into the Earth's atmosphere. The Shuttle's 24,000 individual tiles are made primarily of pure-sand silicate fibers, mixed with a ceramic binder. The solid rocket boosters (SRB's) are designed as an in-house Marshall Space Flight Center project, with United Space Boosters as the assembly and refurbishment contractor. The solid rocket motor (SRM) is provided by the Morton Thiokol Corporation.

  2. Fusion-Enabled Pluto Orbiter and Lander (United States)

    Thomas, Stephanie


    The Pluto orbiter mission proposed here is credible and exciting. The benefits to this and all outer-planet and interstellar-probe missions are difficult to overstate. The enabling technology, Direct Fusion Drive, is a unique fusion engine concept based on the Princeton Field-Reversed Configuration (PFRC) fusion reactor under development at the Princeton Plasma Physics Laboratory. The truly game-changing levels of thrust and power in a modestly sized package could integrate with our current launch infrastructure while radically expanding the science capability of these missions. During this Phase I effort, we made great strides in modeling the engine efficiency, thrust, and specific impulse and analyzing feasible trajectories. Based on 2D fluid modeling of the fusion reactors outer stratum, its scrape-off-layer (SOL), we estimate achieving 2.5 to 5 N of thrust for each megawatt of fusion power, reaching a specific impulse, Isp, of about 10,000 s. Supporting this model are particle-in-cell calculations of energy transfer from the fusion products to the SOL electrons. Subsequently, this energy is transferred to the ions as they expand through the magnetic nozzle and beyond. Our point solution for the Pluto mission now delivers 1000 kg of payload to Pluto orbit in 3.75 years using 7.5 N constant thrust. This could potentially be achieved with a single 1 MW engine. The departure spiral from Earth orbit and insertion spiral to Pluto orbit require only a small portion of the total delta-V. Departing from low Earth orbit reduces mission cost while increasing available mission mass. The payload includes a lander, which utilizes a standard green propellant engine for the landing sequence. The lander has about 4 square meters of solar panels mounted on a gimbal that allows it to track the orbiter, which beams 30 to 50 kW of power using a 1080 nm laser. Optical communication provides dramatically high data rates back to Earth. Our mass modeling investigations revealed that if

  3. Solitary extramedullary plasmacytoma of the maxillary antrum and orbit presenting as acute bacterial orbital cellulitis. (United States)

    Kelly, S. P.; Lloyd, I. C.; Anderson, H.; Joyce, P. W.; Pace-Balzan, A.


    Orbital involvement by plasma cell tumours is rare. Orbital tumours do not generally present as an acute orbital inflammatory disease in adults, though tumours such as rhabdomyosarcoma may cause clinical signs similar to an acute orbital cellulitis in children. We describe a patient with bacterial orbital cellulitis and sinusitis who was found to have an extra-medullary plasmacytoma of the maxillary antrum and orbit and coexisting testicular seminoma. Images PMID:1854702

  4. 'Orbital volume restoration rate after orbital fracture'; a CT-based orbital volume measurement for evaluation of orbital wall reconstructive effect. (United States)

    Wi, J M; Sung, K H; Chi, M


    PurposeTo evaluate the effect of orbital reconstruction and factors related to the effect of orbital reconstruction by assessing of orbital volume using orbital computed tomography (CT) in cases of orbital wall fracture.MethodsIn this retrospective study, 68 patients with isolated blowout fractures were evaluated. The volumes of orbits and herniated orbital tissues were determined by CT scans using a three-dimensional reconstruction technique (the Eclipse Treatment Planning System). Orbital CT was performed preoperatively, immediately after surgery, and at final follow ups (minimum of 6 months). We evaluated the reconstructive effect of surgery making a new formula, 'orbital volume reconstruction rate' from orbital volume differences between fractured and contralateral orbits before surgery, immediately after surgery, and at final follow up.ResultsMean volume of fractured orbits before surgery was 23.01±2.60 cm 3 and that of contralateral orbits was 21.31±2.50 cm 3 (P=0.005). Mean volume of the fractured orbits immediately after surgery was 21.29±2.42 cm 3 , and that of the contralateral orbits was 21.33±2.52 cm 3 (P=0.921). Mean volume of fractured orbits at final follow up was 21.50±2.44 cm 3 , and that of contralateral orbits was 21.32±2.50 cm 3 (P=0.668). The mean orbital volume reconstruction rate was 100.47% immediately after surgery and 99.17% at final follow up. No significant difference in orbital volume reconstruction rate was observed with respect to fracture site or orbital implant type. Patients that underwent operation within 14 days of trauma had a better reconstruction rate at final follow up than patients who underwent operation over 14 days after trauma (P=0.039).ConclusionComputer-based measurements of orbital fracture volume can be used to evaluate the reconstructive effect of orbital implants and provide useful quantitative information. Significant reduction of orbital volume is observed immediately after orbital wall

  5. Optimization of the fuel cycle

    International Nuclear Information System (INIS)

    Kidd, S.W.; Balu, K.; Boczar, P.G.; Krebs, W.D.


    The nuclear fuel cycle can be optimized subject to a wide range of criteria. Prime amongst these are economics, sustainability of resources, environmental aspects, and proliferation-resistance of the fuel cycle. Other specific national objectives will also be important. These criteria, and their relative importance, will vary from country to country, and with time. There is no single fuel cycle strategy that is optimal for all countries. Within the short term, the industry is attached to dominant thermal reactor technologies, which themselves have two main variants, a cycle closed by reprocessing of spent fuel and subsequent recycling and a once through one where spent fuel is stored in advance of geological disposal. However, even with current technologies, much can be done to optimize the fuel cycles to meet the relevant criteria. In the long term, resource sustainability can be assured for centuries through the use of fast breeder reactors, supporting high-conversion thermal reactors, possibly also utilizing the thorium cycle. These must, however, meet the other key criteria by being both economic and safe. (author)

  6. Environmental Assessment for the Orbital/Sub-Orbital Program (United States)


    kilograms (kg)], not including mass of the payload. A diagram showing examples of MM-derived target and space launch vehicles is provided in Figure...missions is referred to as the Minotaur IV, while the target launch (sub-orbital) vehicle is called the OSP Heavy. A diagram of these launch vehicles is...Island. (NPS, 2004; USAF, 1998) Threatened and Endangered Species Listed Floral Species Vandenberg AFB represents an

  7. Prospects for Chlorophyll Fluorescence Remote Sensing from the Orbiting Carbon Observatory-2 (United States)

    Frankenberg, Christian; Odell, Chris; Berry, Joseph; Guanter, Luis; Joiner, Joanna; Kohler, Philipp; Pollock, Randy; Taylor, Thomas E.


    The Orbiting Carbon Observatory-2 (OCO-2), scheduled to launch in July 2014, is a NASA mission designed to measure atmospheric CO2. Its main purpose is to allow inversions of net flux estimates of CO2 on regional to continental scales using the total column CO2 retrieved using high-resolution spectra in the 0.76, 1.6, and 2.0 nm ranges. Recently, it was shown that solar-induced chlorophyll fluorescence (SIF), a proxy for gross primary production (GPP, carbon uptake through photosynthesis), can be accurately retrieved from space using high spectral resolution radiances in the 750 nm range from the Japanese GOSAT and European GOME-2 instruments. Here, we use real OCO-2 thermal vacuum test data as well as a full repeat cycle (16 days) of simulated OCO-2 spectra under realistic conditions to evaluate the potential of OCO-2 for retrievals of chlorophyll fluorescence and also its dependence on clouds and aerosols. We find that the single-measurement precision is 0.3-0.5 Wm(exp -2)sr(exp -1) nm(exp -1) (15-25% of typical peak values), better than current measurements from space but still difficult to interpret on a single-sounding basis. The most significant advancement will come from smaller ground-pixel sizes and increased measurement frequency, with a 100-fold increase compared to GOSAT (and about 8 times higher than GOME-2). This will largely decrease the need for coarse spatial and temporal averaging in data analysis and pave the way to accurate local studies.We also find that the lack of full global mapping from the OCO-2 only incurs small representativeness errors on regional averages. Eventually, the combination of net ecosystem exchange (NEE) derived from CO2 source/sink inversions and SIF as proxy for GPP from the same satellite will provide a more process-based understanding of the global carbon cycle.

  8. Changing global carbon cycle

    International Nuclear Information System (INIS)

    Canadell, Pep


    Full text: The increase in atmospheric carbon dioxide (C02) is the single largest human perturbation on the earth's radiative balance contributing to climate change. Its rate of change reflects the balance between anthropogenic carbon emissions and the dynamics of a number of terrestrial and ocean processes that remove or emit C02. It is the long term evolution of this balance that will determine to large extent the speed and magnitude of the human induced climate change and the mitigation requirements to stabilise atmospheric C02 concentrations at any given level. In this talk, we show new trends in global carbon sources and sinks, with particularly focus on major shifts occurring since 2000 when the growth rate of atmospheric C02 has reached its highest level on record. The acceleration in the C02 growth results from the combination of several changes in properties of the carbon cycle, including: acceleration of anthropogenic carbon emissions; increased carbon intensity of the global economy, and decreased efficiency of natural carbon sinks. We discuss in more detail some of the possible causes of the reduced efficiency of natural carbon sinks on land and oceans, such as the decreased net sink in the Southern Ocean and on terrestrial mid-latitudes due to world-wide occurrence of drought. All these changes reported here characterise a carbon cycle that is generating stronger than expected climate forcing, and sooner than expected

  9. A Geometry-Based Cycle Slip Detection and Repair Method with Time-Differenced Carrier Phase (TDCP) for a Single Frequency Global Position System (GPS) + BeiDou Navigation Satellite System (BDS) Receiver


    Qian, Chuang; Liu, Hui; Zhang, Ming; Shu, Bao; Xu, Longwei; Zhang, Rufei


    As the field of high-precision applications based on carriers continues to expand, the development of low-cost, small, modular receivers and their application in diverse scenarios and situations with complex data quality has increased the requirements of carrier-phase data preprocessing. A new geometry-based cycle slip detection and repair method based on Global Position System (GPS) + BeiDou Navigation Satellite System (BDS) is proposed. The method uses a Time-differenced Carrier Phase (TDCP...


    Directory of Open Access Journals (Sweden)

    Anjana Christy Alexander


    Full Text Available BACKGROUND Orbital trauma is significantly disabling and is reported to occur in multiple situations. All traumas to the face require a careful ocular examination including an estimation of the visual acuity of each eye. However, other potentially blinding complications can easily be missed unless they are actively sought. The aim of the study is to study the prevalence and types of ocular involvement in orbital wall fractures. MATERIALS AND METHODS This study is a prospective, hospital-based study of patients with orbital injuries and other associated facial bone fractures reporting to casualty and Department of Ophthalmology in Sree Balaji Medical College and Hospital over a period of two years. The study included 50 consecutive patients of orbital fractures attending our hospital. The statistical significance was analysed using chi-square test. RESULTS Out of the 50 cases, the majority of the participants were males comprising 88% (n-44 and the remaining 12% (n-6 were females. 80% of the males met with road traffic accidents and 68% of them were in the age group of 20 to 40 years. Among the females, 67% met with road traffic accidents and 33% had injury due to slip and fall. The orbital wall fractures were distributed as 52% in the single wall, 28% in two walls and 20% in more than two walls categories. The periocular findings in orbital wall fractures was distributed as 25 with Subconjunctival Haemorrhage (SCH, 16 with periorbital oedema and SCH, 14 with ecchymosis, 14 with pupil abnormality (mydriasis and RAPD, 1 with corneal perforation and 6 with lid laceration. 58% of the participants who had visual acuity between 6/6 to 6/6p had single wall fracture. Those who had visual acuity less than 6/12 had more than two walls fracture. There was extraocular movement restriction in 6 patients, which comprises 12%. CONCLUSION 78% of the orbital wall fractures were due to road traffic accidents. 68% of the persons involved were males in the age

  11. Assessment and management of orbital cellulitis. (United States)

    Amin, Nikul; Syed, Irfan; Osborne, Sarah


    Orbital cellulitis is a medical emergency requiring multidisciplinary team involvement. Early diagnosis and intervention is imperative to avoid serious complications. This article provides an evidence-based approach to the assessment and management of patients with orbital cellulitis.

  12. Neutron stars with orbiting light

    International Nuclear Information System (INIS)

    Lukacs, B.


    There is a wide-spread belief in the literature of relativistic astrophysics concerning nonsingular final states of the stellar evolution: the external gravitational field of a physically nonsingular central symmetric body (e.g. a neutron star) is asymptotically empty and simple, i.e. there are no closed or trapped light-like causal geodesics. Present paper shows that this belief is false: some examples are presented for nonsingular bodies with various equations of state, around which there are closed light-like trajectories: 'orbiting light'. The reality of the used equations of state is discussed in detail. Present state of particle physics does not establish the existence of matter with such equations of state, but the hypothetical subquark level of matter may have such equation of state, thus 'subquark-stars' may exist with orbiting light around them. So the criterion of 'nonsingularity' must be further analyzed and accurately defined. (D.Gy.) 24 refs.; 5 figs

  13. Pursuit/evasion in orbit (United States)

    Kelley, H. J.; Cliff, E. M.; Lutze, F. H.


    Maneuvers available to a spacecraft having sufficient propellant to escape an antisatellite satellite (ASAT) attack are examined. The ASAT and the evading spacecraft are regarded as being in circular orbits, and equations of motion are developed for the ASAT to commence a two-impulse maneuver sequence. The ASAT employs thrust impulses which yield a minimum-time-to-rendezvous, considering available fuel. Optimal evasion is shown to involve only in-plane maneuvers, and begins as soon as the ASAT launch information is gathered and thrust activation can be initiated. A closest approach, along with a maximum evasion by the target spacecraft, is calculated to be 14,400 ft. Further research to account for ASATs in parking orbit and for generalization of a continuous control-modeled differential game is indicated.

  14. PCVs Estimation and their Impacts on Precise Orbit Determination of LEOs (United States)

    Chunmei, Z.; WANG, X.


    In the last decade the precise orbit determination (POD) based on GNSS, such as GPS, has been considered as one of the efficient methods to derive orbits of Low Earth Orbiters (LEOs) that demand accuracy requirements. The Earth gravity field recovery and its related researches require precise dynamic orbits of LEOs. With the improvements of GNSS satellites' orbit and clock accuracy, the algorithm optimization and the refinement of perturbation force models, the antenna phase-center variations (PCVs) of space-borne GNSS receiver have become an increasingly important factor that affects POD accuracy. A series of LEOs such as HY-2, ZY-3 and FY-3 with homebred space-borne GNSS receivers have been launched in the past several years in China. Some of these LEOs load dual-mode GNSS receivers of GPS and BDS signals. The reliable performance of these space-borne receivers has been establishing an important foundation for the future launches of China gravity satellites. Therefore, we first evaluate the data quality of on-board GNSS measurement by examining integrity, multipath error, cycle slip ratio and other quality indices. Then we determine the orbits of several LEOs at different altitudes by the reduced dynamic orbit determination method. The corresponding ionosphere-free carrier phase post-fit residual time series are obtained. And then we establish the PCVs model by the ionosphere-free residual approach and analyze the effects of antenna phase-center variation on orbits. It is shown that orbit accuracy of LEO satellites is greatly improved after in-flight PCV calibration. Finally, focus on the dual-mode receiver of FY-3 satellite we analyze the quality of onboard BDS data and then evaluate the accuracy of the FY-3 orbit determined using only BDS measurement onboard. The accuracy of LEO satellites orbit based on BDS would be well improved with the global completion of BDS by 2020.

  15. Understanding Pediatric Bacterial Preseptal and Orbital Cellulitis (United States)

    Gonzalez, Mithra O.; Durairaj, Vikram D.


    Pediatric preseptal and orbital cellulitis are infectious disorders that result in periorbital inflammation. Preseptal cellulitis is often associated with breaches in the skin barrier whereas orbital cellulitis is commonly associated with paranasal sinusitis. Orbital cellulitis may be associated with subperiosteal abscess. It is important to distinguish between preseptal from orbital cellulitis. Clinical examination and diagnostic imaging are useful in determining appropriate management. Patients are usually treated with broad spectrum antibiotics and surgery when indicated. PMID:20616919

  16. A new kinematical definition of orbital eccentricity

    Directory of Open Access Journals (Sweden)

    Ninković S.


    Full Text Available A new concept of orbital eccentricity is given. The dimensionless quantities proposed in the present paper to serve as orbital eccentricities have a kinematical nature. The purpose is to use them in describing the motion for the case of three-dimensional orbits. A comparison done for nearly planar orbits shows that the values of the eccentricities proposed here do not differ significantly from those corresponding to the eccentricities of geometric nature usually applied.

  17. Extended Duration Orbiter Medical Project (United States)

    Leach, C. S.; Pool, S. L.; Sawin, C. F.; Nicogossian, A. E.


    The Extended Duration Orbiter (EDO) program addresses a need for more time to perform experiments and other tasks during Space Shuttle missions. As a part of this program, the Extended Duration Orbiter Medical Project (EDOMP) has been instituted to obtain information about physiologic effects of extending mission duration and the effectiveness of countermeasures against factors that might compromise crew health, safety, or performance on extended-duration missions. Only those investigations that address and characterize operational problems, develop countermeasures, or evaluate the effectiveness of countermeasures will be pursued. The EDOMP investigations will include flight-associated Detailed Supplementary Objectives as well as ground-based studies simulating the influence of microgravity. Investigator teams have been formed in the following areas: biomedical physiology, cardiovascular and fluid/electrolyte physiology, environmental health, muscle and exercise physiology, and neurophysiology. Major operational questions must be answered in each of these areas, and investigations have been designed to answer them. The EDO program will proceed only after countermeasures have been shown to be effective in preventing or mitigating the adverse changes they have been designed to attenuate. The program is underway and will continue on each Shuttle flight as the manifest builds toward a 16-day orbital flight.

  18. Hyaluronidase allergy mimicking orbital cellulitis. (United States)

    Raichura, Nirav D; Alam, Md Shahid; Jaichandran, V V; Mistry, Saurabh; Mukherjee, Bipasha


    Hyaluronidase enzyme is a common additive with local anesthetic agent to facilitate faster permeation of the anesthetic in periocular tissues during ophthalmic surgery. We report a series of five subjects presenting with clinical features mimicking orbital cellulitis following peribulbar anesthesia and consequently diagnosed with hyaluronidase hypersensitivity. The study was conducted at a tertiary eye care center in Southern India. It was a retrospective interventional case series. We retrospectively reviewed the case records of patients diagnosed as and treated for hyaluronidase allergy from 2011 to 2015. The presenting features included periocular edema, proptosis, and restriction of ocular movements. The symptoms appeared immediately after the injection to as late as 6 days after the surgery. All patients underwent comprehensive ophthalmic evaluation, relevant investigations, and dermal allergy tests. All five patients tested positive for hyaluronidase. Patients were treated with antihistaminics, systemic steroids, and emergency orbital decompression, when required. In majority of the patients, symptoms resolved in 3-5 days. Clinically, hyaluronidase allergy may mimic orbital cellulitis, which in the context of a recent intraocular surgery may be alarming for both the patient and the surgeon. However, with prompt intervention, the prognosis is extremely favorable in cases of hyaluronidase allergy. It is important for ophthalmic surgeons and anesthetists to recognize and differentiate this entity from the more serious vision threatening conditions.

  19. Tunable superconducting critical temperature in ballistic hybrid structures with strong spin-orbit coupling (United States)

    Simensen, Haakon T.; Linder, Jacob


    We present a theoretical description and numerical simulations of the superconducting transition in hybrid structures including strong spin-orbit interactions. The spin-orbit coupling is taken to be of Rashba type for concreteness, and we allow for an arbitrary magnitude of the spin-orbit strength as well as an arbitrary thickness of the spin-orbit coupled layer. This allows us to make contact with the experimentally relevant case of enhanced interfacial spin-orbit coupling via atomically thin heavy metal layers. We consider both interfacial spin-orbit coupling induced by inversion asymmetry in an S/F junction, as well as in-plane spin-orbit coupling in the ferromagnetic region of an S/F/S and an S/F structure. Both the pair amplitudes, local density of states, and critical temperature show dependency on the Rashba strength and, importantly, the orientation of the exchange field. In general, spin-orbit coupling increases the critical temperature of a proximity system where a magnetic field is present, and enhances the superconducting gap in the density of states. We perform a theoretical derivation which explains these results by the appearance of long-ranged singlet correlations. Our results suggest that Tc in ballistic spin-orbit coupled superconducting structures may be tuned by using only a single ferromagnetic layer.

  20. A Polycycle and Limit Cycles in a Non-Differentiable Predator-Prey ...

    Indian Academy of Sciences (India)

    For a non-differentiable predator-prey model, we establish conditions for the existence of a heteroclinic orbit which is part of one contractive polycycle and for some values of the parameters, we prove that the heteroclinic orbit is broken and generates a stable limit cycle. In addition, in the parameter space, we prove that ...

  1. Orbital-Transfer Vehicle With Aerodynamic Braking (United States)

    Scott, C. D.; Nagy, K.; Roberts, B. B.; Ried, R. C.; Kroll, K.; Gamble, J.


    Vehicle includes airbrake for deceleration into lower orbit. Report describes vehicle for carrying payloads between low and high orbits around Earth. Vehicle uses thin, upper atmosphere for braking when returning to low orbit. Since less propellant needed than required for full retrorocket braking, vehicle carries larger payload and therefore reduces cost of space transportation.

  2. Traumatic orbital encephalocele: Presentation and imaging. (United States)

    Wei, Leslie A; Kennedy, Tabassum A; Paul, Sean; Wells, Timothy S; Griepentrog, Greg J; Lucarelli, Mark J


    Traumatic orbital encephalocele is a rare but severe complication of orbital roof fractures. We describe 3 cases of orbital encephalocele due to trauma in children. Retrospective case series from the University of Wisconsin - Madison and Medical College of Wisconsin. Three cases of traumatic orbital encephalocele in pediatric patients were found. The mechanism of injury was motor vehicle accident in 2 patients and accidental self-inflicted gunshot wound in 1 patient. All 3 patients sustained orbital roof fractures (4 mm to 19 mm in width) and frontal lobe contusions with high intracranial pressure. A key finding in all 3 cases was progression of proptosis and globe displacement 4 to 11 days after initial injury. On initial CT, all were diagnosed with extraconal hemorrhage adjacent to the roof fractures, with subsequent enlargement of the mass and eventual diagnosis of encephalocele. Orbital encephalocele is a severe and sight-threatening complication of orbital roof fractures. Post-traumatic orbital encephalocele can be challenging to diagnose on CT as patients with this condition often have associated orbital and intracranial hematoma, which can be difficult to distinguish from herniated brain tissue. When there is a high index of suspicion for encephalocele, an MRI of the orbits and brain with contrast should be obtained for additional characterization. Imaging signs that should raise suspicion for traumatic orbital encephalocele include an enlarging heterogeneous orbital mass in conjunction with a roof fracture and/or widening fracture segments.

  3. On Directional Measurement Representation in Orbit Determination (United States)


    Precision Orbit Determination (OD) is often critical for successful satellite operations supporting a wide variety of missions. Directional or angles only...representations. The three techniques are then compared experimentally for a geostationary and a low Earth orbit satellite using simulated data to evaluate their... Orbit Determination (OD) is often critical for successful satellite operations supporting a wide variety of missions. Precision OD involves

  4. Prospective Ukrainian lunar orbiter mission (United States)

    Shkuratov, Y.; Litvinenko, L.; Shulga, V.; Yatskiv, Y.; Kislyuk, V.

    Ukraine has launch vehicles that are able to deliver about 300 kg to the lunar orbit. Future Ukrainian lunar program may propose a polar orbiter. This orbiter should fill principal information gaps in our knowledge about the Moon after Clementine and Lunar Prospector missions and the future missions, like Smart-1, Lunar-A, and Selene. We consider that this can be provided by radar studies of the Moon with supporting optical polarimetric observations from lunar polar orbit. These experiments allow one to better understand global structure of the lunar surface in a wide range of scales, from microns to kilometers. We propose three instruments for the prospective lunar orbiter. They are: a synthetic aperture imaging radar (SAR), ground-penetrating radar (GPR), and imaging polarimeter (IP). The main purpose of SAR is to study with high resolution (50 m) the permanently shadowed sites in the lunar polar regions. These sites are cold traps for volatiles, and have a potential of resource utilization. Possible presence of water ice in the regolith in the sites makes them interesting for permanent manned bases on the Moon. Radar imaging and mapping of other interesting regions could be also planned. Multi-frequencies multi-polarization soun d ing of the lunar surface with GPR can provide information about internal structure of the lunar surface from meters to several hundred meters deep. GPR can be used for measuring the megaregolith layer properties, detection of cryptomaria, and studies of internal structure of the largest craters. IP will be a CCD camera with an additional suite of polarizers. Modest spatial resolution (100 m) should provide a total coverage or a large portion of the lunar surface in oblique viewing basically at large phase angles. Polarization degree at large (>90°) phase angles bears information about characteristic size of the regolith particles. Additional radiophysical experiments are considered with the use of the SAR system, e.g., bistatic radar

  5. Innovation and Business Cycles


    Festré, Agnès


    The main purpose of this chapter is to assess the originality of Schumpeter's theory of business cycles. The first section outlines the distinctive features of Schumpeter's approach to business cycles and economic dynamics. Section two looks at the mechanisms constituting the cycle in Schumpeter's two major contributions on this subject, the Theory of Economic Development (1911) and Business Cycles (1939).

  6. The fuel cycle

    International Nuclear Information System (INIS)


    In this brochure the fuel cycle is presented. The following fuel cycle steps are described: (1) Front of the fuel cycle (Mining and milling; Treatment; Refining, conversion and enrichment; Fuel fabrication); (2) Use of fuel in nuclear reactors; (3) Back end of the fuel cycle (Interim storage of spent fuel; spent fuel reprocessing; Final disposal of spent fuel)

  7. Parameningeal rhabdomyosarcoma (including the orbit): results of orbital irradiation

    International Nuclear Information System (INIS)

    Jereb, B.; Haik, B.G.; Ong, R.; Ghavimi, F.


    Twenty-three patients with parameningeal (including orbital rhabdomyosarcoma (RMS)) were treated at Memorial Sloan-Kettering Cancer Center (MSKCC) between July 1971 and January 1983. Twenty were children with a mean age of 6 and 3 were adults. In 6 patients, the primary tumor was from the orbit, whereas the remaining 17 had other parameningeal primary sites. The tumors were in a very progressive local stage, with extensive destruction of the facial bones in 19 patients. Eight patients were treated with T2 chemotherapy protocol and 15 received T6. Seven patients received 5,000 to 7,200 rad delivered to the primary tumor in 11-16 weeks, 15 patients received between 4,500 to 5,000 rad in 4-7 weeks, and 1 patient received 3,000 rad in 3 weeks for residual microscopic disease following surgery. Two patients were treated with radiation to the whole brain; no patients received radiation of the whole central nervous axis (CNA). Fifteen of the 23 patients (65%) are alive and well with a medical follow-up time of 5 years. Two patients died of therapeutic complications and six died of tumor spread. In five patients, involvement of the central nervous system (CNS) was the cause of death. The prognosis of orbital RMS with parameningeal involvement is no better than in other tumors of parameningeal sites. In those patients who had impaired vision because of optic nerve damage prior to treatment, the vision did not improve following treatment. There was no impaired vision seen due to radiation damage of eye structures except in the lens

  8. Precision orbit raising trajectories. [solar electric propulsion orbital transfer program (United States)

    Flanagan, P. F.; Horsewood, J. L.; Pines, S.


    A precision trajectory program has been developed to serve as a test bed for geocentric orbit raising steering laws. The steering laws to be evaluated have been developed using optimization methods employing averaging techniques. This program provides the capability of testing the steering laws in a precision simulation. The principal system models incorporated in the program are described, including the radiation environment, the solar array model, the thrusters and power processors, the geopotential, and the solar system. Steering and array orientation constraints are discussed, and the impact of these constraints on program design is considered.

  9. Four Years on Orbit at the Moon with LOLA (United States)

    Smith, D. E.; Zuber, M. T.; Neumann, G. A.; Mazarico, E.; Torrence, M. H.; Lemoine, F. G.


    After four years of near-continuous operation at the Moon, the Lunar Orbiter Laser Altimeter (LOLA) continues to collect altimetry, surface roughness, slope and normal reflectance data. Although the instrument is beginning to show the effects of tens of thousands of thermal cycles and the natural process of the aging of the laser transmitters, LOLA continues to acquire data on the sunlit portion of every orbit on all 5 laser beams when below 100-km altitude. LOLA has acquired over 6x10^9 altimeter measurements, all geodetically controlled to the center-of-mass of the Moon with a radial precision of around 10 cm and an accuracy of about 1 meter. The position of the measurements on the lunar surface is primarily limited by the knowledge of the position of the spacecraft in orbit; in the last year the LRO orbit accuracy has improved significantly as a result of the availability of an accurate gravity model of the Moon from the GRAIL Discovery mission. Our present estimate of positional accuracy is less than 10 m rms but is only achievable with a GRAIL gravity model to at least degree and order 600 because of the perturbing gravitational effect of the Moon's surface features. Significant improvements in the global shape and topography have assisted the Lunar Reconnaissance Orbiter Camera (LROC) stereo mapping program, and the identification of potential lunar landing sites for ESA and Russia, particularly in the high-latitude polar regions where 5- and 10-meter average horizontal resolution has been obtained. LOLA's detailed mapping of the polar regions has improved the delineation of permanently-shadowed areas and assisted in the understanding of the LEND neutron data and its relationship to surface slopes. Recently, a global, calibrated LOLA normal albedo dataset at 1064 nm has been developed and is being combined with analysis and modeling by the Diviner team for the identification of the coldest locations in the polar regions.

  10. JASON-1 Precise Orbit Determination (POD)with SLR and DORIS Tracking (United States)

    Zelensky, N. P.; Luthcke, S. B.; Rowlands, D. D.; Beckley, B. D.; Lemoine, Frank G.; Wang, Y. M.; Chinn, D. S.; Williams, T. A.


    Jason-1, the TOPEX/POSEIDON (T/P) radar altimeter follow-on, is intended to continue measurement of the ocean surface with the same, if not better accuracy. T/P has demonstrated that, the time variation of ocean topography can be determined with an accuracy of a few centimeters, thanks to the availability of highly accurate orbits based on SLR and DORIS tracking. For verification and cross-calibration, Jason-1, was initially injected into the T/P orbit, flying just 72 seconds ahead of T/P. This configuration lasted over 21 Jason cycles. In mid-August T/P was maneuvered into its final tandem configuration, a parallel groundtrack, in order to improve the combined coverage. Preliminary investigations using cycles 1-9, shown at the June 2002 SWT, indicated that nominal Jason orbits can achieve the 2-3 cm accuracy objective, however several puzzling aspects of SLR and DORIS measurement modeling were also observed. This paper presents recent analysis of Jason SLR+DORIS POD spanning more than 20 cycles, and revisits several of the more puzzling issues, including estimation of the Laser Retroreflector Array (LRA) offset. The accuracy of the orbits and of the measurement modeling are evaluated using several tests, including SLR, DORIS, and altimeter crossover residual analysis, altimeter collinear analysis, and direct comparison with GPS and other orbits. T/P POD results over the same period are used as a reference.

  11. The OrbitOutlook Data Archive (United States)

    Czajkowski, M.; Shilliday, A.; LoFaso, N.; Dipon, A.; Van Brackle, D.


    In this paper, we describe and depict the Defense Advanced Research Projects Agency (DARPA)'s OrbitOutlook Data Archive (OODA) architecture. OODA is the infrastructure that DARPA's OrbitOutlook program has developed to integrate diverse data from various academic, commercial, government, and amateur space situational awareness (SSA) telescopes. At the heart of the OODA system is its world model - a distributed data store built to quickly query big data quantities of information spread out across multiple processing nodes and data centers. The world model applies a multi-index approach where each index is a distinct view on the data. This allows for analysts and analytics (algorithms) to access information through queries with a variety of terms that may be of interest to them. Our indices include: a structured global-graph view of knowledge, a keyword search of data content, an object-characteristic range search, and a geospatial-temporal orientation of spatially located data. In addition, the world model applies a federated approach by connecting to existing databases and integrating them into one single interface as a "one-stop shopping place" to access SSA information. In addition to the world model, OODA provides a processing platform for various analysts to explore and analytics to execute upon this data. Analytic algorithms can use OODA to take raw data and build information from it. They can store these products back into the world model, allowing analysts to gain situational awareness with this information. Analysts in turn would help decision makers use this knowledge to address a wide range of SSA problems. OODA is designed to make it easy for software developers who build graphical user interfaces (GUIs) and algorithms to quickly get started with working with this data. This is done through a multi-language software development kit that includes multiple application program interfaces (APIs) and a data model with SSA concepts and terms such as: space

  12. The chromosome cycle of prokaryotes (United States)

    Kuzminov, Andrei


    Summary In both eukaryotes and prokaryotes, chromosomal DNA undergoes replication, condensation-decondensation and segregation, sequentially, in some fixed order. Other conditions, like sister-chromatid cohesion (SCC), may span several chromosomal events. One set of these chromosomal transactions within a single cell cycle constitutes the “chromosome cycle”. For many years it was generally assumed that the prokaryotic chromosome cycle follows major phases of the eukaryotic one: -replication-condensation-segregation-(cell division)-decondensation-, with SCC of unspecified length. Eventually it became evident that, in contrast to the strictly consecutive chromosome cycle of eukaryotes, all stages of the prokaryotic chromosome cycle run concurrently. Thus, prokaryotes practice “progressive” chromosome segregation separated from replication by a brief SCC, and all three transactions move along the chromosome at the same fast rate. In other words, in addition to replication forks, there are “segregation forks” in prokaryotic chromosomes. Moreover, the bulk of prokaryotic DNA outside the replication-segregation transition stays compacted. I consider possible origins of this concurrent replication-segregation and outline the “nucleoid administration” system that organizes the dynamic part of the prokaryotic chromosome cycle. PMID:23962352

  13. Long-term Stability of Tightly Packed Multi-planet Systems in Prograde, Coplanar, Circumstellar Orbits within the α Centauri AB System (United States)

    Quarles, B.; Lissauer, Jack J.


    We perform long-term simulations, up to ten billion years, of closely spaced configurations of 2–6 planets, each as massive as the Earth, traveling on nested orbits about either stellar component in α Centauri AB. The innermost planet initially orbits at either the inner edge of its star’s empirical habitable zone (HZ) or the inner edge of its star’s conservative HZ. Although individual planets on low inclination, low eccentricity, orbits can survive throughout the HZs of both stars, perturbations from the companion star require that the minimum spacing of planets in multi-planet systems within the HZs of each star must be significantly larger than the spacing of similar multi-planet systems orbiting single stars in order to be long-lived. The binary companion induces a forced eccentricity upon the orbits of planets in orbit around either star. Planets on appropriately phased circumstellar orbits with initial eccentricities equal to their forced eccentricities can survive on more closely spaced orbits than those with initially circular orbits, although the required spacing remains higher than for planets orbiting single stars. A total of up to nine planets on nested prograde orbits can survive for the current age of the system within the empirical HZs of the two stars, with five of these orbiting α Centauri B and four orbiting α Centauri A.

  14. Metabolic Interaction between Urea Cycle and Citric Acid Cycle Shunt: A Guided Approach (United States)

    Pesi, Rossana; Balestri, Francesco; Ipata, Piero L.


    This article is a guided pedagogical approach, devoted to postgraduate students specializing in biochemistry, aimed at presenting all single reactions and overall equations leading to the metabolic interaction between ureagenesis and citric acid cycle to be incorporated into a two-three lecture series about the interaction of urea cycle with other…

  15. Management of preseptal and orbital cellulitis (United States)

    Lee, Seongmu; Yen, Michael T.


    Orbital cellulitis describes an infection involving the soft tissues posterior to the orbital septum, including the fat and muscle within the bony orbit. This condition may be associated with severe sight and life-threatening complications. Despite significant advances in antimicrobial therapies and diagnostic technologies, the management of orbital cellulitis often remains challenging, and rapid diagnosis and prompt initiation of therapy are important in minimizing complications and optimizing outcomes. This review summarizes the distinctive characteristics of preseptal and orbital cellulitis, with a focus on anatomic considerations, predisposing conditions, approaches to evaluation, and management strategies. PMID:23960899

  16. Novel Surgical Approaches to the Orbit (United States)

    Campbell, Ashley A.; Grob, Seanna R.; Yoon, Michael K.


    Determining safe surgical access to the orbit can be difficult given the complex anatomy and delicacy of the orbital structures. When considering biopsy or removal of an orbital tumor or repair of orbital fractures, careful planning is required to determine the ideal approach. Traditionally, this has at times necessitated invasive procedures with large incisions and extensive bone removal. The purpose of this review was to present newly techniques and devices in orbital surgery that have been reported over the past decade, with aims to provide better exposure and/or minimally invasive approaches and to improve morbidity and/or mortality. PMID:26692713

  17. Sentinel-3 coverage-driven mission design: Coupling of orbit selection and instrument design (United States)

    Cornara, S.; Pirondini, F.; Palmade, J. L.


    The first satellite of the Sentinel-3 series was launched in February 2016. Sentinel-3 payload suite encompasses the Ocean and Land Colour Instrument (OLCI) with a swath of 1270 km, the Sea and Land Surface Temperature Radiometer (SLSTR) yielding a dual-view scan with swaths of 1420 km (nadir) and 750 km (oblique view), the Synthetic Aperture Radar Altimeter (SRAL) working in Ku-band and C-band, and the dual-frequency Microwave Radiometer (MWR). In the early stages of mission and system design, the main driver for the Sentinel-3 reference orbit selection was the requirement to achieve a revisit time of two days or less globally over ocean areas with two satellites (i.e. 4-day global coverage with one satellite). The orbit selection was seamlessly coupled with the OLCI instrument design in terms of field of view (FoV) definition driven by the observation zenith angle (OZA) and sunglint constraints applied to ocean observations. The criticality of the global coverage requirement for ocean monitoring derives from the sunglint phenomenon, i.e. the impact on visible channels of the solar ray reflection on the water surface. This constraint was finally overcome thanks to the concurrent optimisation of the orbit parameters, notably the Local Time at Descending Node (LTDN), and the OLCI instrument FoV definition. The orbit selection process started with the identification of orbits with short repeat cycle (2-4 days), firstly to minimise the time required to achieve global coverage with existing constraints, and then to minimise the swath required to obtain global coverage and the maximum required OZA. This step yielded the selection of a 4-day repeat cycle orbit, thus allowing 2-day coverage with two adequately spaced satellites. Then suitable candidate orbits with higher repeat cycles were identified in the proximity of the selected altitudes and the reference orbit was ultimately chosen. Rationale was to keep the swath for global coverage as close as possible to the

  18. Orbits in weak and strong bars

    CERN Document Server

    Contopoulos, George


    The authors study the plane orbits in simple bar models embedded in an axisymmetric background when the bar density is about 1% (weak), 10% (intermediate) or 100% (strong bar) of the axisymmetric density. Most orbits follow the stable periodic orbits. The basic families of periodic orbits are described. In weak bars with two Inner Lindblad Resonances there is a family of stable orbits extending from the center up to the Outer Lindblad Resonance. This family contains the long period orbits near corotation. Other stable families appear between the Inner Lindblad Resonances, outside the Outer Lindblad Resonance, around corotation (short period orbits) and around the center (retrograde). Some families become unstable or disappear in strong bars. A comparison is made with cases having one or no Inner Lindblad Resonance. (12 refs).

  19. Test of the periodic-orbit approximation in n-disk systems

    International Nuclear Information System (INIS)

    Wirzba, A.


    The scattering of a point particle in two dimensions from two (or three) equally-sized (and spaced) circular hard disks is one of the simplest classically hyperbolic scattering problems. Because of this simplicity such systems are well suited for the study of the semiclassical periodic-orbit approximation in the cycle expansion of the dynamical zeta function applied to a quantum-mechanical scattering problem. Especially the predictions of the semiclassical cycle expansion for the quantum-mechanical resonances can be tested in these n-disk systems. Whereas for high wave numbers the cycle expansion gives quite accurate results, there are systematic deviations for low wave numbers from the exact quantum-mechanical values. The low-lying quantum-mechanical resonance poles of the 2- and 3-disk problem are constructed and compared to the cycle-expansion results. The characteristic determinant of the scattering matrix is expanded in terms of simple traces which in turn are related to the classical periodic orbits and possible creeping contributions. It will be shown that for large separations of the disks the correct resonance-pole positions can be extracted just from the knowledge of the lowest traces whose semiclassical limit are the fundamental periodic orbits. Creeping-orbit corrections are shown to be small. (orig.)

  20. Orbiting Carbon Observatory-2 (OCO-2): Science Overview and A-Train Synergy (United States)

    Crisp, David


    NASA's Orbiting Carbon Observatory (OCO) was designed to provide global estimates of atmospheric carbon dioxide (CO2) with the sensitivity, accuracy and sampling density needed to quantify regional scale carbon sources and sinks and characterize their behavior over the annual cycle.

  1. Orbit Transfer Vehicle Engine Study. Phase A, extension 1: Study plan update (United States)

    Mellish, J. A.


    The updated study plan for the Space Transportation System orbit transfer vehicle (OTV) engine study is presented. The study program consists of engine system, programmatic, cost, and risk analyses of OTV engine concepts. Detailed task descriptions for the advanced expander cycle engine optimization, alternate low thrust capability, and safety, reliability, and cost comparisons are given.

  2. Monitoring city wide patterns of cycling safety. (United States)

    Boss, Darren; Nelson, Trisalyn; Winters, Meghan


    Many cities are making significant financial investments in cycling infrastructure with the aim of making cycling safer for riders of all ages and abilities. Methods for evaluating cycling safety tend to summarize average change for a city or emphasize change on a single road segment. Few spatially explicit approaches are available to evaluate how patterns of safety change throughout a city due to cycling infrastructure investments or other changes. Our goal is to demonstrate a method for monitoring changes in the spatial-temporal distribution of cycling incidents across a city. Using cycling incident data provided by the Insurance Corporation of British Columbia, we first compare planar versus network constrained kernel density estimation for visualizing incident intensity across the street network of Vancouver, Canada. Second, we apply a change detection algorithm explicitly designed for detecting statistically significant change in kernel density estimates. The utility of network kernel density change detection is demonstrated through the comparison of cycling incident densities following the construction of two cycle tracks in the downtown core of Vancouver. The methods developed and demonstrated for this study provide city planners, transportation engineers and researchers a means of monitoring city-wide change in the intensity of cycling incidents following enhancements to cycling infrastructure or other significant changes to the transportation network. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. Dynamic MRI of orbital lesions

    Energy Technology Data Exchange (ETDEWEB)

    Sawada, Akihiro; Matsumoto, Hiroko (Kochi Medical School, Nangoku (Japan))


    Study of time intensity curves was performed for 15 orbital lesions. Inflammatory lesions (2 chronic dacryoadenitis, 1 chalazion, 1 inflammatory pseudotumor), 1 meningioma, and 4 pseudolymphoma showed rapid increase with run off. They showed peak formations within 2 minutes. Tumors except for meningioma (3 malignant lymphoma, 2 retinoblastoma, 1 pleomorphic adenoma of lacrimal gland) showed gradual increase without peak formation. No difference between benign and malignancy was detected. Dynamic MRI would be useful for differential diagnosis between pseudotumor and malignant lymphoma, that has been difficult for imaging diagnosis so far. (author).

  4. Orbiter fuel cell improvement assessment

    International Nuclear Information System (INIS)

    Johnson, R.E.


    The history of fuel cells and the theory of fuel cells is given. Expressions for thermodynamic and electrical efficiencies are developed. The voltage losses due to electrode activation, ohmic resistance and ionic diffusion are discussed. Present limitations of the Orbiter Fuel Cell, as well as proposed enhancements, are given. These enhancements are then evaluated and recommendations are given for fuel cell enhancement both for short-range as well as long-range performance improvement. Estimates of reliability and cost savings are given for enhancements where possible

  5. Berry phases on Virasoro orbits (United States)

    Oblak, Blagoje


    We point out that unitary representations of the Virasoro algebra contain Berry phases obtained by acting on a primary state with conformal transformations that trace a closed path on a Virasoro coadjoint orbit. These phases can be computed exactly thanks to the Maurer-Cartan form on the Virasoro group, and they persist after combining left- and right-moving sectors. Thinking of Virasoro representations as particles in AdS3 dressed with boundary gravitons, the Berry phases associated with Brown-Henneaux diffeomorphisms provide a gravitational extension of Thomas precession.

  6. Orbital Volumetry in Graves' Orbitopathy

    DEFF Research Database (Denmark)

    Al-Bakri, Moug; Rasmussen, Åse Krogh; Thomsen, Carsten


    .6 cm(3) in controls, 8.7 ± 8.0 cm(3) in GO without DON, and 9.4 ± 3.1 cm(3) in GO with DON. The muscle and fat volumes were higher in patients with GO than in controls (P optic nerve were......Purpose. We wanted to investigate the relative significance of fat and muscle enlargement in the development of dysthyroid optic neuropathy (DON) in Graves' orbitopathy (GO). Methods. Preoperative coronal CT scans of 13 patients with and without DON who subsequently underwent orbital decompression...

  7. Cassini at Saturn Proximal Orbits - Attitude Control Challenges (United States)

    Burk, Thomas A.


    The Cassini mission at Saturn will come to an end in the spring and summer of 2017 with a series of 22 orbits that will dip inside the rings of Saturn. These are called proximal orbits and will conclude with spacecraft disposal into the atmosphere of the ringed world on September 15, 2017. These unique orbits that cross the ring plane only a few thousand kilometers above the cloud tops of the planet present new attitude control challenges for the Cassini operations team. Crossing the ring plane so close to the inner edge of the rings means that the Cassini orientation during the crossing will be tailored to protect the sensitive electronics bus of the spacecraft. This orientation will put the sun sensors at some extra risk so this paper discusses how the team prepares for dust hazards. Periapsis is so close to the planet that spacecraft controllability with RCS thrusters needs to be evaluated because of the predicted atmospheric torque near closest approach to Saturn. Radiation during the ring plane crossings will likely trigger single event transients in some attitude control sensors. This paper discusses how the attitude control team deals with radiation hazards. The angular size and unique geometry of the rings and Saturn near periapsis means that star identification will be interrupted and this paper discusses how the safe mode attitude is selected to best deal with these large bright bodies during the proximal orbits.

  8. Monodromy matrix theory of Trojan wave packets on elliptical orbits (United States)

    Kalinski, Matt


    The possibility of existence of so called Trojan wavepackets on elliptical orbits, nondispersing wave packets once predicted on cirular orbits while the Hydrogen atom is placed in the CP field has been predicted both theoretically [1] and after many years finally confirmed experimentally in recent microwave experiments. They are caused by so called population lock on the resonance with the infinite semi-harmonic but nonlinear spectrum. However no extension of harmonic theory has been given which simply explains the phenomenon as generalized concept of the Paul trap in the atom but for the single electron. Hereby we apply the monodromy matrix theory originally developed by Heller [2] to study such phenomenon. We define the instantaneous Hamiltonian for the electron an the elliptical orbit and surprisingly find out that it needs not to have real eigenvalues for all times of the circular motion while the packed motion is still nondispersing. Numerical simulations using split-operator method are also presented. [1] E. A. Shapiro, M. Kalinski, and J. H. Eberly, ``Non-circular Trojan-like wavepackets: quantum theory and application to quantum control,'' J. Phys. B 33, 3079, (2000); [2] E. J. Heller, ``Bound-State Eigenfunctions of Classically Chaotic Hamiltonian Systems: Scars of Periodic Orbits,'' Phys. Rev. Lett. 53, 1515 (1984).

  9. Solar radio proxies for improved satellite orbit prediction (United States)

    Yaya, Philippe; Hecker, Louis; Dudok de Wit, Thierry; Fèvre, Clémence Le; Bruinsma, Sean


    Specification and forecasting of solar drivers to thermosphere density models is critical for satellite orbit prediction and debris avoidance. Satellite operators routinely forecast orbits up to 30 days into the future. This requires forecasts of the drivers to these orbit prediction models such as the solar Extreme-UV (EUV) flux and geomagnetic activity. Most density models use the 10.7 cm radio flux (F10.7 index) as a proxy for solar EUV. However, daily measurements at other centimetric wavelengths have also been performed by the Nobeyama Radio Observatory (Japan) since the 1950's, thereby offering prospects for improving orbit modeling. Here we present a pre-operational service at the Collecte Localisation Satellites company that collects these different observations in one single homogeneous dataset and provides a 30 days forecast on a daily basis. Interpolation and preprocessing algorithms were developed to fill in missing data and remove anomalous values. We compared various empirical time series prediction techniques and selected a multi-wavelength non-recursive analogue neural network. The prediction of the 30 cm flux, and to a lesser extent that of the 10.7 cm flux, performs better than NOAA's present prediction of the 10.7 cm flux, especially during periods of high solar activity. In addition, we find that the DTM-2013 density model (Drag Temperature Model) performs better with (past and predicted) values of the 30 cm radio flux than with the 10.7 flux.

  10. The Precise Orbit and the Challenge of Long Term Stability (United States)

    Lemoine, Frank G.; Cerri, Luca; Otten, Michiel; Bertiger, William; Zelensky, Nikita; Willis, Pascal


    the future remains a source of error. Other sources of omission error include the geocenter for which no consensus model is as of yet applied. Although progress has been made in nonconservative force modeling through the use of detailed satellite-specific models, radiation pressure modeling, and atmospheric density modeling remain a potential source of orbit error. The longer term influence of variations in the solar and terrestrial radiation fields over annual and solar cycles remains principally untested. Also the long term variation in optical and thermal properties of the space vehicle surfaces would contribute to biases in the orbital frame if ignored. We review the status of altimetric precision orbit determination as exemplified by the recent computations undertaken by the different analysis centers for ERS, Envisat, TOPEX/Poseidon, Jason, Cryosat2 and HY2A, and we provide a perspective on the challenges for future missions such as the Jason-3, SENTINEL-3 and SWOT.

  11. Proliferation in cycle

    Energy Technology Data Exchange (ETDEWEB)

    Piao Yunsong [College of Physical Sciences, Graduate School of Chinese Academy of Sciences, Beijing 100049 (China)], E-mail:


    In the contracting phase with w{approx_equal}0, the scale invariant spectrum of curvature perturbation is given by the increasing mode of metric perturbation. In this Letter, it is found that if the contracting phase with w{approx_equal}0 is included in each cycle of a cycle universe, since the metric perturbation is amplified on super horizon scale cycle by cycle, after each cycle the universe will be inevitably separated into many parts independent of one another, each of which corresponds to a new universe and evolves up to next cycle, and then is separated again. In this sense, a cyclic multiverse scenario is actually presented, in which the universe proliferates cycle by cycle. We estimate the number of new universes proliferated in each cycle, and discuss the implications of this result.

  12. Cosmic Origins Spectrograph: On-Orbit Performance of Target Acquisitions (United States)

    Penton, Steven V.


    COS is a slit-less spectrograph with a very small aperture (R=1.2500). To achieve the desired wavelength accuracies, HST+COS must center the target to within 0.100 of the center of the aperture for the FUV channel, and 0.0400 for NUV. During SMOV and early Cycle 17 we fine-tuned the COS target acquisition (TA) procedures to exceed this accuracy for all three COS TA modes; NUV imaging, NUV spectroscopic, and FUV spectroscopic. In Cycle 17, we also adjusted the COSto- FGS offsets in the SIAF file. This allows us to recommend skipping the time consuming ACQ/SEARCH in cases where the target coordinates are well known. Here we will compare the on-orbit performance of all COS TA modes in terms of centering accuracy, efficiency, and required signal-to-noise (S/N).

  13. Precise orbit analysis and global verification results from ERS-1 altimetry (United States)

    Shum, C. K.; Tapley, B. D.; Kozel, B. J.; Visser, P.; Ries, J. C.; Seago, J.


    A technique which employs dual satellite crossover measurements from ERS-1 and Topology Ocean Experiment (TOPEX)/Poseidon together with laser tracking data and single satellite crossover measurements for ERS-1 precision orbit determination is described. The accuracy assessment of the resulting ERS-1 orbit is provided. Results of global verification of the ERS-1 Ocean Products (OPR02) and the Interim Geophysical Data Records (IGDR) data products in terms of altimeter bias, time lag bias and sea state bias are presented.

  14. Mission Design for NASA's Inner Heliospheric Sentinels and ESA's Solar Orbiter Missions (United States)

    Downing, John; Folta, David; Marr, Greg; Rodriquez-Canabal, Jose; Conde, Rich; Guo, Yanping; Kelley, Jeff; Kirby, Karen


    This paper will document the mission design and mission analysis performed for NASA's Inner Heliospheric Sentinels (IHS) and ESA's Solar Orbiter (SolO) missions, which were conceived to be launched on separate expendable launch vehicles. This paper will also document recent efforts to analyze the possibility of launching the Inner Heliospheric Sentinels and Solar Orbiter missions using a single expendable launch vehicle, nominally an Atlas V 551.

  15. On a boom and bust year class cycle

    NARCIS (Netherlands)

    Diekmann, Odo; Davydova, Natalia; van Gils, Stephanus A.


    We motivate and describe a class of nonlinear Leslie matrix models for semelparous populations, like cicadas and Pacific salmon. We then focus on a Cushing-inspired special case for which one can show rigorously that a heteroclinic boundary cycle exists and attracts nearby orbits for a certain range

  16. Role of Negative Orbit Vector in Orbital Blow-Out Fractures. (United States)

    Choi, Soo Youn; Lee, Hwa; Baek, Sehyun


    Negative orbit vector is defined as the most anterior globe portion protrudes past the malar eminence. The aim of the study was to evaluate the relationship between negative orbit vector and blow-out fracture location analyzing the distance between the anterior corneal surface and orbital bone with facial soft tissue in medial and orbital floor blow out fractures using orbital computed tomography (CT). Seventy-seven patients diagnosed with blow-out fractures involving the medial or orbital floor were included. Distances from the anterior cornea to lower lid fat, inferior orbital wall, inferior orbital rim, and anterior cheek mass were measured using orbital CT scans. The proportion of negative orbit vector and measured distanced were compared between medial wall fracture and orbital floor fracture. Medical records including age, sex, concomitant ophthalmic diagnosis, and nature of injury were retrospectively reviewed. Forty-three eyes from 43 patients diagnosed with medial wall fracture and 34 eyes from 34 patients diagnosed with orbital floor fracture were included. There was no significant difference in the distance from the anterior cornea to lower lid fat (P = 0.574), inferior orbital wall (P = 0.494), or orbital rim (P = 0.685). The distance from anterior cornea to anterior cheek mass was significantly different in medial wall fracture (-0.19 ± 3.49 mm) compared with orbital floor fracture (-1.69 ± 3.70 mm), P = 0.05. Negative orbit vector was significantly higher in orbital floor fracture patients (24 among 34 patients, 70.6%) compared with those with medial wall fractures (19 among 43 patients, 44.2%) (P = 0.04). Patients presenting with a negative orbit vector relationship when the most anterior portion of globe protruded past the anterior cheek mass and malar eminence were more likely to develop orbital floor fracture than medial wall fracture.

  17. Analytical study of orbital selective Mott transition using slave-spin method (United States)

    Komijani, Yashar; Kotliar, Gabriel

    We study the orbital selective Mott transition using slave-spin and slave-boson techniques. Within a single-site approximation, we identify the competing ground states of the spin-sector of a two-band Hubbard Hamiltonian in presence of the Hund's rule coupling as well as inter-orbital tunneling and provide an analytical explanation for the orbital correlation (mode locking) and Kondo physics. By mapping the lattice to the impurity model we make connections to the dynamical mean-field theory.

  18. Poynting vector and orbital angular momentum density of superpositions of Bessel beams

    CSIR Research Space (South Africa)

    Litvin, IA


    Full Text Available . Courtial, ?Measuring the orbital angular momentum of a single photon,? Phys. Rev. Lett. 88(25), 257901 (2002). 15. C. Gao, X. Qi, Y. Liu, J. Xin, and L. Wang, ?Sorting and detecting orbital angular momentum states by using a Dove prism embedded Mach.... Rev. Lett. 75(5), 826?829 (1995). 7. A. Mair, A. Vaziri, G. Weihs, and A. Zeilinger, ?Entanglement of the orbital angular momentum states of photons,? Nature 412(6844), 313?316 (2001). 8. A. Vaziri, G. Weihs, and A. Zeilinger, ?Experimental two-photon...


    Energy Technology Data Exchange (ETDEWEB)

    Spalding, Christopher; Batygin, Konstantin [Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125 (United States)


    During its five-year mission, the Kepler spacecraft has uncovered a diverse population of planetary systems with orbital configurations ranging from single-transiting planets to systems of multiple planets co-transiting the parent star. By comparing the relative occurrences of multiple to single-transiting systems, recent analyses have revealed a significant over-abundance of singles. Dubbed the “ Kepler Dichotomy,” this feature has been interpreted as evidence for two separate populations of planetary systems: one where all orbits are confined to a single plane, and a second where the constituent planetary orbits possess significant mutual inclinations, allowing only a single member to be observed in transit at a given epoch. In this work, we demonstrate that stellar obliquity, excited within the disk-hosting stage, can explain this dichotomy. Young stars rotate rapidly, generating a significant quadrupole moment, which torques the planetary orbits, with inner planets influenced more strongly. Given nominal parameters, this torque is sufficiently strong to excite significant mutual inclinations between planets, enhancing the number of single-transiting planets, sometimes through a dynamical instability. Furthermore, as hot stars appear to possess systematically higher obliquities, we predict that single-transiting systems should be relatively more prevalent around more massive stars. We analyze the Kepler data and confirm this signal to be present.

  20. The earth orbiting space debris

    Directory of Open Access Journals (Sweden)

    Rossi A.


    Full Text Available The space debris population is similar to the asteroid belt, since it is subject to a process of high-velocity mutual collisions that affects the long-term evolution of its size distribution. Presently, more than 10 000 artificial debris particles with diameters larger than 10 cm (and more than 300 000 with diameters larger than 1 cm are orbiting the Earth, and are monitored and studied by a large network of sensors around the Earth. Many objects of different kind compose the space debris population, produced by different source mechanisms ranging from high energy fragmentation of large spacecraft to slow diffusion of liquid metal. The impact against a space debris is a serious risk that every spacecraft must face now and it can be evaluated with ad-hoc algorithms. The long term evolution of the whole debris population is studied with computer models allowing the simulation of all the known source and sink mechanisms. One of these codes is described in this paper and the evolution of the debris environment over the next 100 years, under different traffic scenarios, is shown, pointing out the possible measures to mitigate the growth of the orbital debris population. .