WorldWideScience

Sample records for single migration cycle

  1. Business cycles, migration and health.

    Science.gov (United States)

    Halliday, Timothy J

    2007-04-01

    We investigate the proposition that illness poses as an obstacle to one's ability to use migration to hedge the business cycle. We employ data on migration, regional unemployment rates and health status from 10 years (1984-1993) of the US Panel Study of Income Dynamics. Our results provide considerable for support this proposition. The evidence is the strongest for men, but we also find weaker evidence for married women. These results suggest that--ceterus paribus--aggregate health outcomes in an area should improve when the regional economy expands.

  2. Using Single-Protein Tracking to Study Cell Migration.

    Science.gov (United States)

    Orré, Thomas; Mehidi, Amine; Massou, Sophie; Rossier, Olivier; Giannone, Grégory

    2018-01-01

    To get a complete understanding of cell migration, it is critical to study its orchestration at the molecular level. Since the recent developments in single-molecule imaging, it is now possible to study molecular phenomena at the single-molecule level inside living cells. In this chapter, we describe how such approaches have been and can be used to decipher molecular mechanisms involved in cell migration.

  3. Comparison of migration behavior between single and dual lag screw implants for intertrochanteric fracture fixation

    Directory of Open Access Journals (Sweden)

    Katonis Pavlos G

    2009-05-01

    Full Text Available Abstract Background Lag screw cut-out failure following fixation of unstable intertrochanteric fractures in osteoporotic bone remains an unsolved challenge. This study tested if resistance to cut-out failure can be improved by using a dual lag screw implant in place of a single lag screw implant. Migration behavior and cut-out resistance of a single and a dual lag screw implant were comparatively evaluated in surrogate specimens using an established laboratory model of hip screw cut-out failure. Methods Five dual lag screw implants (Endovis, Citieffe and five single lag screw implants (DHS, Synthes were tested in the Hip Implant Performance Simulator (HIPS of the Legacy Biomechanics Laboratory. This model simulated osteoporotic bone, an unstable fracture, and biaxial rocking motion representative of hip loading during normal gait. All constructs were loaded up to 20,000 cycles of 1.45 kN peak magnitude under biaxial rocking motion. The migration kinematics was continuously monitored with 6-degrees of freedom motion tracking system and the number of cycles to implant cut-out was recorded. Results The dual lag screw implant exhibited significantly less migration and sustained more loading cycles in comparison to the DHS single lag screw. All DHS constructs failed before 20,000 cycles, on average at 6,638 ± 2,837 cycles either by cut-out or permanent screw bending. At failure, DHS constructs exhibited 10.8 ± 2.3° varus collapse and 15.5 ± 9.5° rotation around the lag screw axis. Four out of five dual screws constructs sustained 20,000 loading cycles. One dual screw specimens sustained cut-out by medial migration of the distal screw after 10,054 cycles. At test end, varus collapse and neck rotation in dual screws implants advanced to 3.7 ± 1.7° and 1.6 ± 1.0°, respectively. Conclusion The single and double lag screw implants demonstrated a significantly different migration resistance in surrogate specimens under gait loading simulation with

  4. Irregular migration and informal economy in Southern and Central-Eastern Europe: breaking the vicious cycle?

    Science.gov (United States)

    Maroukis, Thanos; Iglicka, Krystyna; Gmaj, Katarzyna

    2011-01-01

    The flexible and cheap labour that European “post-industrial” economies are in need of is often facilitated by undeclared labour. The undocumented migrant, from his/her part, relatively easily finds work that suits his -- at least initial -- plans. What lies behind this nexus between irregular migration and informal economy? To what extent can this nexus be attributed to the structural features of the so-called “secondary”, as opposed to “primary”, labour market? And how does migration policy correlate with this economic context and lead to the entrapment of migrants in irregularity? Finally, can this vicious cycle of interests and life-strategies be broken and what does the experience of the migrants indicate in this respect? This paper addresses these questions via an exploration of the grounds upon which irregular migration and the shadow economy complement each other in southern Europe (SE) and central and Eastern Europe (CEE) (two regions at different points in the migration cycle). In doing so, the dynamic character of the nexus between informal economy and irregular migration will come to the fore, and the abstract identity of the “average” undocumented migrant will be deconstructed.

  5. Next generation GNSS single receiver cycle slip reliability

    NARCIS (Netherlands)

    Teunissen, P.J.G.; De Bakker, P.F.

    2009-01-01

    In this contribution we study the multi-frequency, carrier-phase slip detection capabilities of a single receiver. Our analysis is based on an analytical expression that we present for themulti-frequencyminimal detectable carrier phase cycle slip.

  6. Single generation cycles and delayed feedback cycles are not separate phenomena.

    Science.gov (United States)

    Pfaff, T; Brechtel, A; Drossel, B; Guill, C

    2014-12-01

    We study a simple model for generation cycles, which are oscillations with a period of one or a few generation times of the species. The model is formulated in terms of a single delay-differential equation for the population density of an adult stage, with recruitment to the adult stage depending on the intensity of competition during the juvenile phase. This model is a simplified version of a group of models proposed by Gurney and Nisbet, who were the first to distinguish between single-generation cycles and delayed-feedback cycles. According to these authors, the two oscillation types are caused by different mechanisms and have periods in different intervals, which are one to two generation times for single-generation cycles and two to four generation times for delayed-feedback cycles. By abolishing the strict coupling between the maturation time and the time delay between competition and its effect on the population dynamics, we find that single-generation cycles and delayed-feedback cycles occur in the same model version, with a gradual transition between the two as the model parameters are varied over a sufficiently large range. Furthermore, cycle periods are not bounded to lie within single octaves. This implies that a clear distinction between different types of generation cycles is not possible. Cycles of all periods and even chaos can be generated by varying the parameters that determine the time during which individuals from different cohorts compete with each other. This suggests that life-cycle features in the juvenile stage and during the transition to the adult stage are important determinants of the dynamics of density limited populations. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Chapter 10 the primary cilium coordinates signaling pathways in cell cycle control and migration during development and tissue repair

    DEFF Research Database (Denmark)

    Christensen, Søren T; Pedersen, Stine F; Satir, Peter

    2008-01-01

    Cell cycle control and migration are critical processes during development and maintenance of tissue functions. Recently, primary cilia were shown to take part in coordination of the signaling pathways that control these cellular processes in human health and disease. In this review, we present...... an overview of the function of primary cilia and the centrosome in the signaling pathways that regulate cell cycle control and migration with focus on ciliary signaling via platelet-derived growth factor receptor alpha (PDGFRalpha). We also consider how the primary cilium and the centrosome interact...... with the extracellular matrix, coordinate Wnt signaling, and modulate cytoskeletal changes that impinge on both cell cycle control and cell migration....

  8. Numerical examination of the factors controlling DNAPL migration through a single fracture.

    Science.gov (United States)

    Reynolds, D A; Kueper, B H

    2002-01-01

    The migration of five dense nonaqueous phase liquids (DNAPLs) through a single fracture in a clay aquitard was numerically simulated with the use of a compositional simulator. The effects of fracture aperture, fracture dip, matrix porosity, and matrix organic carbon content on the migration of chlorobenzene, 1,2-dichloroethylene, trichloroethylene, tetra-chloroethylene, and 1,2-dibromoethane were examined. Boundary conditions were chosen such that DNAPL entry into the system was allowed to vary according to the stresses applied. The aperture is the most important factor of those studied controlling the migration rate of DNAPL through a single fracture embedded in a clay matrix. Loss of mass to the matrix through diffusion does not significantly retard the migration rate of the DNAPL, particularly in larger aperture fractures (e.g., 50 microm). With time, the ratio of diffusive loss to the matrix to DNAPL flux into the fracture approaches an asymptotic value lower than unity. The implication is that matrix diffusion cannot arrest the migration of DNAPL in a single fracture. The complex relationships between density, viscosity, and solubility that, to some extent, govern the migration of DNAPL through these systems prevent accurate predictions without the use of numerical models. The contamination potential of the migrating DNAPL is significantly increased through the transfer of mass to the matrix. The occurrence of opposite concentration gradients within the matrix can cause dissolved phase contamination to exist in the system for more than 1000 years after the DNAPL has been completely removed from the fracture.

  9. Generation of a single-cycle optical pulse

    International Nuclear Information System (INIS)

    Shverdin, M.Y.; Walker, D.R.; Yavuz, D.D.; Yin, G.Y.; Harris, S.E.

    2005-01-01

    We make use of coherent control of four-wave mixing to the ultraviolet as a diagnostic and describe the generation of a periodic optical waveform where the spectrum is sufficiently broad that the envelope is approximately a single-cycle in length, and where the temporal shape of this envelope may be synthesized by varying the coefficients of a Fourier series. Specifically, using seven sidebands, we report the generation of a train of single-cycle optical pulses with a pulse width of 1.6 fs, a pulse separation of 11 fs, and a peak power of 1 MW

  10. Edible crabs "go west": migrations and incubation cycle of Cancer pagurus revealed by electronic tags.

    Directory of Open Access Journals (Sweden)

    Ewan Hunter

    Full Text Available Crustaceans are key components of marine ecosystems which, like other exploited marine taxa, show seasonable patterns of distribution and activity, with consequences for their availability to capture by targeted fisheries. Despite concerns over the sustainability of crab fisheries worldwide, difficulties in observing crabs' behaviour over their annual cycles, and the timings and durations of reproduction, remain poorly understood. From the release of 128 mature female edible crabs tagged with electronic data storage tags (DSTs, we demonstrate predominantly westward migration in the English Channel. Eastern Channel crabs migrated further than western Channel crabs, while crabs released outside the Channel showed little or no migration. Individual migrations were punctuated by a 7-month hiatus, when crabs remained stationary, coincident with the main period of crab spawning and egg incubation. Incubation commenced earlier in the west, from late October onwards, and brooding locations, determined using tidal geolocation, occurred throughout the species range. With an overall return rate of 34%, our results demonstrate that previous reluctance to tag crabs with relatively high-cost DSTs for fear of loss following moulting is unfounded, and that DSTs can generate precise information with regards life-history metrics that would be unachievable using other conventional means.

  11. Bank Credit Risk Management and Rating Migration Analysis on the Business Cycle

    Directory of Open Access Journals (Sweden)

    Dimitris Gavalas

    2014-03-01

    Full Text Available Credit risk measurement remains a critical field of top priority in banking finance, directly implicated in the recent global financial crisis. This paper examines the dynamic linkages between credit risk migration due to rating shifts and prevailing macroeconomic conditions, reflected in alternative business cycle states. An innovative empirical methodology applies to bank internal rating data, under different economic scenarios and investigates the implications of credit risk quality shifts for risk rating transition matrices. The empirical findings are useful and critical for banks to align to Basel guidelines in relation to core capital requirements and risk-weighted assets in the underlying loan portfolio.

  12. Modelling of flow and contaminant migration in single rock fractures

    International Nuclear Information System (INIS)

    Dahlblom, P.; Joensson, L.

    1990-03-01

    The report deals with flow and hydrodynamic dispersion of a nonreactive contaminant in a single, irregularly shaped fracture. The main purpose of the report is to describe the basis and development of a computational 'tool' for simulating the aperture geometry of a single fracture and the detailed flow in it. On the basis of this flow information further properties of the fracture can be studied. Some initial application to dispersion of a nonreactive contaminant are thus discussed. The spatial pattern of variation of the fracture aperture is considered as a two-dimensional stochastic process. A method for simulation of such a process is described. The stochastic properties can be chosen arbitrarily. It is assumed that the fracture aperture belongs to a log-normal distribution. For calculation of the flow pattern, the Navier-Stokes equations are simplified to describe low velocity and steady-state flow. These equations, and the continuity equation are integrated in the direction across the fracture plane. A stream function, which describes the integrated flow in the fracture, is defined. A second order partial differential equation, with respect to the stream function, is established and solved by the finite difference method. Isolines for the stream function define boundaries between channels with equal flow rates. The travel time for each channel can be calculated to achieve a measure of the dispersion. The impact of the aperture distribution on the ratio between the mass balance fracture aperture and the cubic law fracture aperture is shown by simple examples. (28 figs., 1 tab., 22 refs.)

  13. Risk factors for venous port migration in a single institute in Taiwan.

    Science.gov (United States)

    Fan, Wen-Chieh; Wu, Cheng-Han; Tsai, Ming-Ju; Tsai, Ying-Ming; Chang, Hsu-Liang; Hung, Jen-Yu; Chen, Pei-Huan; Yang, Chih-Jen

    2014-01-14

    An implantable port device provides an easily accessible central route for long-term chemotherapy. Venous catheter migration is one of the rare complications of venous port implantation. It can lead to side effects such as pain in the neck, shoulder, or ear, venous thrombosis, and even life-threatening neurologic problems. To date, there are few published studies that discuss such complications. This retrospective study of venous port implantation in a single center, a Taiwan hospital, was conducted from January 2011 to March 2013. Venous port migration was recorded along with demographic and characteristics of the patients. Of 298 patients with an implantable import device, venous port migration had occurred in seven, an incidence rate of 2.3%. All seven were male and had received the Bard port Fr 6.6 which had smaller size than TYCO port Fr 7.5 and is made of silicon. Significantly, migration occurred in male patients (P = 0.0006) and in those with lung cancer (P = 0.004). Multivariable logistic regression analysis revealed that lung cancer was a significant risk factor for port migration (odds ratio: 11.59; P = 0.0059). The migration rate of the Bard port Fr 6.6 was 6.7%. The median time between initial venous port implantation and port migration was 35.4 days (range, 7 to 135 days) and 71.4% (5/7) of patients had port migration within 30 days after initial port implantation. Male sex and lung cancer are risk factors for venous port migration. The type of venous port is also an important risk factor.

  14. Single-cycle adenovirus vectors in the current vaccine landscape.

    Science.gov (United States)

    Barry, Michael

    2018-02-01

    Traditional inactivated and protein vaccines generate strong antibodies, but struggle to generate T cell responses. Attenuated pathogen vaccines generate both, but risk causing the disease they aim to prevent. Newer gene-based vaccines drive both responses and avoid the risk of infection. While these replication-defective (RD) vaccines work well in small animals, they can be weak in humans because they do not replicate antigen genes like more potent replication-competent (RC) vaccines. RC vaccines generate substantially stronger immune responses, but also risk causing their own infections. To circumvent these problems, we developed single-cycle adenovirus (SC-Ad) vectors that amplify vaccine genes, but that avoid the risk of infection. This review will discuss these vectors and their prospects for use as vaccines. Areas covered: This review provides a background of different types of vaccines. The benefits of gene-based vaccines and their ability to replicate antigen genes are described. Adenovirus vectors are discussed and compared to other vaccine types. Replication-defective, single-cycle, and replication-competent Ad vaccines are compared. Expert commentary: The potential utility of these vaccines are discussed when used against infectious diseases and as cancer vaccines. We propose a move away from replication-defective vaccines towards more robust replication-competent or single-cycle vaccines.

  15. Energetic and exergetic Improvement of geothermal single flash cycle

    Directory of Open Access Journals (Sweden)

    Navid Nazari

    2016-08-01

    Full Text Available This paper presents a detailed analysis of a new method for improving energetic and exergetic efficiencies of single flash cycle. The thermodynamic process of the new method consists of extracting a fraction of hot wellhead geothermal brine for the purpose of superheating saturated steam entering the turbine. Computer programming scripts were developed and optimized based on mathematical proposed models for the different components of the systems. The operating parameters such as separator temperature, geofluid wellhead enthalpy and geothermal source temperature are varied to investigate their effects on both net power output and turbine exhaust quality of the systems. Also, full exergy assessment was performed for the new design. The results of separator temperature optimization revealed that specific net power output of the new design can be boosted up to 8% and turbine exhaust quality can be diminished up to 50% as compared to common single flash cycle. In addition, for wells with higher discharge enthalpy, superheating process improve specific net power output even up to 10%. Finally, it was observed that the overall system exergy efficiency was approximately raised 3%. Article History: Received January 5th 2016; Received in revised form June 25th 2016; Accepted July 3rd 2016; Available online How to Cite This Article: Nazari, N. and Porkhial, S. (2016. Energetic and Exergetic Improvement of Geothermal Single Flash Cycle. Int. Journal of Renewable Energy Development, 5(2,129-138. http://dx.doi.org/10.14710/ijred.5.2.129-138 

  16. What motivates single women to migrate from northern Ghana to Accra?

    NARCIS (Netherlands)

    Tufuor, Theresa; Sato, Chizu

    2017-01-01

    In recent decades there has been a large migration stream of single women from the north to Accra in Ghana. Existing studies have focused on young migrant women’s livelihood strategies in their place of destination. However, once-married women – divorced and widowed women and neglected wives – also

  17. Macrophage/epithelium cross-talk regulates cell cycle progression and migration in pancreatic progenitors.

    Directory of Open Access Journals (Sweden)

    Kristin Mussar

    Full Text Available Macrophages populate the mesenchymal compartment of all organs during embryogenesis and have been shown to support tissue organogenesis and regeneration by regulating remodeling of the extracellular microenvironment. Whether this mesenchymal component can also dictate select developmental decisions in epithelia is unknown. Here, using the embryonic pancreatic epithelium as model system, we show that macrophages drive the epithelium to execute two developmentally important choices, i.e. the exit from cell cycle and the acquisition of a migratory phenotype. We demonstrate that these developmental decisions are effectively imparted by macrophages activated toward an M2 fetal-like functional state, and involve modulation of the adhesion receptor NCAM and an uncommon "paired-less" isoform of the transcription factor PAX6 in the epithelium. Over-expression of this PAX6 variant in pancreatic epithelia controls both cell motility and cell cycle progression in a gene-dosage dependent fashion. Importantly, induction of these phenotypes in embryonic pancreatic transplants by M2 macrophages in vivo is associated with an increased frequency of endocrine-committed cells emerging from ductal progenitor pools. These results identify M2 macrophages as key effectors capable of coordinating epithelial cell cycle withdrawal and cell migration, two events critical to pancreatic progenitors' delamination and progression toward their differentiated fates.

  18. Macrophage/epithelium cross-talk regulates cell cycle progression and migration in pancreatic progenitors.

    Science.gov (United States)

    Mussar, Kristin; Tucker, Andrew; McLennan, Linsey; Gearhart, Addie; Jimenez-Caliani, Antonio J; Cirulli, Vincenzo; Crisa, Laura

    2014-01-01

    Macrophages populate the mesenchymal compartment of all organs during embryogenesis and have been shown to support tissue organogenesis and regeneration by regulating remodeling of the extracellular microenvironment. Whether this mesenchymal component can also dictate select developmental decisions in epithelia is unknown. Here, using the embryonic pancreatic epithelium as model system, we show that macrophages drive the epithelium to execute two developmentally important choices, i.e. the exit from cell cycle and the acquisition of a migratory phenotype. We demonstrate that these developmental decisions are effectively imparted by macrophages activated toward an M2 fetal-like functional state, and involve modulation of the adhesion receptor NCAM and an uncommon "paired-less" isoform of the transcription factor PAX6 in the epithelium. Over-expression of this PAX6 variant in pancreatic epithelia controls both cell motility and cell cycle progression in a gene-dosage dependent fashion. Importantly, induction of these phenotypes in embryonic pancreatic transplants by M2 macrophages in vivo is associated with an increased frequency of endocrine-committed cells emerging from ductal progenitor pools. These results identify M2 macrophages as key effectors capable of coordinating epithelial cell cycle withdrawal and cell migration, two events critical to pancreatic progenitors' delamination and progression toward their differentiated fates.

  19. Contact Kinematics Correlates to Tibial Component Migration Following Single Radius Posterior Stabilized Knee Replacement.

    Science.gov (United States)

    Teeter, Matthew G; Perry, Kevin I; Yuan, Xunhua; Howard, James L; Lanting, Brent A

    2018-03-01

    Contact kinematics between total knee arthroplasty components is thought to affect implant migration; however, the interaction between kinematics and tibial component migration has not been thoroughly examined in a modern implant system. A total of 24 knees from 23 patients undergoing total knee arthroplasty with a single radius, posterior stabilized implant were examined. Patients underwent radiostereometric analysis at 2 and 6 weeks, 3 and 6 months, and 1 and 2 years to measure migration of the tibial component in all planes. At 1 year, patients also had standing radiostereometric analysis examinations acquired in 0°, 20°, 40°, and 60° of flexion, and the location of contact and magnitude of any condylar liftoff was measured for each flexion angle. Regression analysis was performed between kinematic variables and migration at 1 year. The average magnitude of maximum total point motion across all patients was 0.671 ± 0.270 mm at 1 year and 0.608 ± 0.359 mm at 2 years (P = .327). Four implants demonstrated continuous migration of >0.2 mm between the first and second year of implantation. There were correlations between the location of contact and tibial component anterior-posterior tilt, varus-valgus tilt, and anterior-posterior translation. The patients with continuous migration demonstrated atypical kinematics and condylar liftoff in some instances. Kinematics can influence tibial component migration, likely through alterations of force transmission. Abnormal kinematics may play a role in long-term implant loosening. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. Migration rates of brine inclusions in single crystals of NaCl

    International Nuclear Information System (INIS)

    Chou, I.M.

    1982-01-01

    Rock-salt deposits have been considered as a possible medium for the permanent storage of high-level radioactive wastes and spent fuel. Brine inclusions present in natural salt can migrate toward the waste if the temperature and the temperature gradients in the vicinity of the radioactive waste are large enough. This migration is due to the dissolution of salt at the hot side of the salt-brine interface, ion diffusion through the brine droplet, and the precipitation of salt at the cold side of the salt brine interface. In order to quantify the problem, the migration rate of these brine inclusions must be estimated under various repository conditions. This paper estimates migration rates for all-liquid brine inclusions in single crystals of NaCl by utilizing recent data for brines and the model of Anthony and Cline [T.R. Anthony and H.E. Cline, J. Appl. Phys., 42, pp. 3380-387 (1971)]. The predictions are compared with experimentally measured migration rates. 4 figures, 6 tables

  1. Risk factors for venous port migration in a single institute in Taiwan

    OpenAIRE

    Fan, Wen-Chieh; Wu, Cheng-Han; Tsai, Ming-Ju; Tsai, Ying-Ming; Chang, Hsu-Liang; Hung, Jen-Yu; Chen, Pei-Huan; Yang, Chih-Jen

    2014-01-01

    Background An implantable port device provides an easily accessible central route for long-term chemotherapy. Venous catheter migration is one of the rare complications of venous port implantation. It can lead to side effects such as pain in the neck, shoulder, or ear, venous thrombosis, and even life-threatening neurologic problems. To date, there are few published studies that discuss such complications. Methods This retrospective study of venous port implantation in a single center, a Taiw...

  2. Spawning migration of the horseshoe crab, Tachypleus gigas (Muller), in relation to lunal cycle

    Digital Repository Service at National Institute of Oceanography (India)

    Chatterji, A.; Rathod, V.; Parulekar, A.H.

    Effects of lunar phases and tidal height on the spawning migration of the horseshoe crab, Tachypleus gigas, along the northeastern coast of India were studied. Mature pairs of crabs migrate towards the shore and build their nests in sandy beaches...

  3. Migration of uranium process wastes from the uranium-233--thorium-232 cycle

    International Nuclear Information System (INIS)

    Fried, S.; Sabau, C.; Hines, J.; Friedman, A.

    1978-03-01

    With the advent of fuel loadings of 233 U in the Shippingport Reactor, it has become important to understand the migratory behavior of uranium. The purpose of this study is the determination of the parameters influencing the migration of U(VI), the most likely chemical form of uranium to be mobilized from a repository. Samples of rhyolite tuff were used to measure the absorption coefficients of solutions of U(VI) in ground waters. In addition, columns of tuff were used to measure the elution behavior of U(VI) at various conditions of pH, U(VI) concentration, and flow saturation. These results indicate that there are several elution peaks with values of K/sub d/ between 35 and 120. This behavior is not the same as that of Pu(VI) on tuff; and the experimental results to date have not revealed the reason for this difference. Values of K/sub d/ in this range imply that geological containment would be difficult in strata of this type. It may be possible to find more retentive strata than tuff. Rocks containing reducing components are the most likely candidates and further investigation is urgently needed if the 233 U-Th cycle is to be widely used

  4. Point defects in lines in single crystalline phosphorene: directional migration and tunable band gaps.

    Science.gov (United States)

    Li, Xiuling; Ma, Liang; Wang, Dayong; Zeng, Xiao Cheng; Wu, Xiaojun; Yang, Jinlong

    2016-10-20

    Extended line defects in two-dimensional (2D) materials can play an important role in modulating their electronic properties. During the experimental synthesis of 2D materials, line defects are commonly generated at grain boundaries between domains of different orientations. In this work, twelve types of line-defect structures in single crystalline phosphorene are examined by using first-principles calculations. These line defects are typically formed via migration and aggregation of intrinsic point defects, including the Stone-Wales (SW), single or double vacancy (SV or DV) defects. Our calculated results demonstrate that the migration of point defects in phosphorene is anisotropic, for instance, the lowest migration energy barriers are 1.39 (or 0.40) and 2.58 (or 0.49) eV for SW (or SV) defects in zigzag and armchair directions, respectively. The aggregation of point defects into lines is energetically favorable compared with the separated point defects in phosphorene. In particular, the axis of line defects in phosphorene is direction-selective, depending on the composed point defects. The presence of line defects effectively modulates the electronic properties of phosphorene, rendering the defect-containing phosphorene either metallic or semiconducting with a tunable band gap. Of particular interest is the fact that the SV-based line defect can behave as a metallic wire, suggesting a possibility to fabricate a circuit with subnanometer widths in the semiconducting phosphorene for nanoscale electronic application.

  5. The Caenorhabditis elegans Q neuroblasts: A powerful system to study cell migration at single-cell resolution in vivo.

    Science.gov (United States)

    Rella, Lorenzo; Fernandes Póvoa, Euclides E; Korswagen, Hendrik C

    2016-04-01

    During development, cell migration plays a central role in the formation of tissues and organs. Understanding the molecular mechanisms that drive and control these migrations is a key challenge in developmental biology that will provide important insights into disease processes, including cancer cell metastasis. In this article, we discuss the Caenorhabditis elegans Q neuroblasts and their descendants as a tool to study cell migration at single-cell resolution in vivo. The highly stereotypical migration of these cells provides a powerful system to study the dynamic cytoskeletal processes that drive migration as well as the evolutionarily conserved signaling pathways (including different Wnt signaling cascades) that guide the cells along their specific trajectories. Here, we provide an overview of what is currently known about Q neuroblast migration and highlight the live-cell imaging, genome editing, and quantitative gene expression techniques that have been developed to study this process. © 2016 Wiley Periodicals, Inc.

  6. A Comparison of Single-Cycle Versus Multiple-Cycle Proof Testing Strategies

    Science.gov (United States)

    McClung, R. C.; Chell, G. G.; Millwater, H. R.; Russell, D. A.; Millwater, H. R.

    1999-01-01

    Single-cycle and multiple-cycle proof testing (SCPT and MCPT) strategies for reusable aerospace propulsion system components are critically evaluated and compared from a rigorous elastic-plastic fracture mechanics perspective. Earlier MCPT studies are briefly reviewed. New J-integral estimation methods for semielliptical surface cracks and cracks at notches are derived and validated. Engineering methods are developed to characterize crack growth rates during elastic-plastic fatigue crack growth (FCG) and the tear-fatigue interaction near instability. Surface crack growth experiments are conducted with Inconel 718 to characterize tearing resistance, FCG under small-scale yielding and elastic-plastic conditions, and crack growth during simulated MCPT. Fractography and acoustic emission studies provide additional insight. The relative merits of SCPT and MCPT are directly compared using a probabilistic analysis linked with an elastic-plastic crack growth computer code. The conditional probability of failure in service is computed for a population of components that have survived a previous proof test, based on an assumed distribution of initial crack depths. Parameter studies investigate the influence of proof factor, tearing resistance, crack shape, initial crack depth distribution, and notches on the MCPT versus SCPT comparison. The parameter studies provide a rational basis to formulate conclusions about the relative advantages and disadvantages of SCPT and MCPT. Practical engineering guidelines are proposed to help select the optimum proof test protocol in a given application.

  7. Vitrified/warmed single blastocyst transfer in preimplantation genetic diagnosis/preimplantation genetic screening cycles.

    Science.gov (United States)

    Huang, Jin; Li, Rong; Lian, Ying; Chen, Lixue; Shi, Xiaodan; Qiao, Jie; Liu, Ping

    2015-01-01

    To investigate the single blastocyst transfer in preimplantation genetic diagnosis (PGD)/preimplantation genetic screening (PGS) cycles. 80 PGD/PGS cycles undergoing blastocyst biopsy were studied. There were 88 warming cycles during the study period. Only one warmed blastocyst was transferred per cycle. The outcomes were followed up to the infants were born. The embryo implantation rate was 54.55% (48/88). The clinical pregnancy rate was 54.55% (48/88) per transfer cycle and 60% (48/80) per initial PGD/PGS cycle. There was no multi-pregnant in this study. The live birth rate was 42.05% (37/88) per transfer cycle and 46.25% (37/80) per initial PGD/PGS cycle. In PGD/PGS cycles, single blastocyst transfer reduces the multiple pregnancy rate without affecting the clinical outcomes.

  8. Rp58 and p27kip1 coordinate cell cycle exit and neuronal migration within the embryonic mouse cerebral cortex.

    Science.gov (United States)

    Clément, Olivier; Hemming, Isabel Anne; Gladwyn-Ng, Ivan Enghian; Qu, Zhengdong; Li, Shan Shan; Piper, Michael; Heng, Julian Ik-Tsen

    2017-05-15

    During the development of the mammalian cerebral cortex, newborn postmitotic projection neurons are born from local neural stem cells and must undergo radial migration so as to position themselves appropriately to form functional neural circuits. The zinc finger transcriptional repressor Rp58 (also known as Znf238 or Zbtb18) is critical for coordinating corticogenesis, but its underlying molecular mechanism remains to be better characterised. Here, we demonstrate that the co-expression of Rp58 and the cyclin dependent kinase inhibitor (CDKI) p27 kip1 is important for E14.5-born cortical neurons to coordinate cell cycle exit and initiate their radial migration. Notably, we find that the impaired radial positioning of Rp58-deficient cortical neurons within the embryonic (E17.5) mouse cortex, as well as their multipolar to bipolar transition from the intermediate zone to the cortical plate can be restored by forced expression of p27 kip1 in concert with suppression of Rnd2, a downstream target gene of Rp58. Furthermore, the restorative effects of p27 kip1 and Rnd2 abrogation are reminiscent of suppressing RhoA signalling in Rp58-deficient cells. Our findings demonstrate functional interplay between a transcriptional regulator and a CDKI to mediate neuroprogenitor cell cycle exit, as well as to promote radial migration through a molecular mechanism consistent with suppression of RhoA signalling.

  9. Thermal gradient migration of brine inclusions in synthetic alkali halide single crystals

    International Nuclear Information System (INIS)

    Olander, D.R.; Machiels, A.J.; Balooch, M.; Yagnik, S.K.

    1982-01-01

    An apparatus consisting of an optical microscope with a hot stage attachment capable of simultaneously nonuniformly heating and mechanically loading small single crystals of salt was used to measure the velocities of all-liquid inclusions NaC1 and KC1 specimens under various conditions of temperature, temperature gradient, and uniaxial stress. The rate-controlling elementary step in the migration of the inclusions was found to be associated with interfacial processes, probably dissolution of the hot face. Dislocations are required for this step to take place. The small number of dislocation intersections with small inclusions in nearly perfect crystals causes substantial variations in the velocity, a sensitivity of the velocity to mechanical loading of the crystal, and a velocity which varies approximately as the second power of the temperature gradient

  10. STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells.

    Directory of Open Access Journals (Sweden)

    Pankaj Goyal

    Full Text Available BACKGROUND: Migration and proliferation of vascular endothelial cells are essential for repair of injured endothelium and angiogenesis. Cyclins, cyclin-dependent kinases (CDKs, and cyclin-dependent kinase inhibitors play an important role in vascular tissue injury and wound healing. Previous studies suggest a link between the cell cycle and cell migration: cells present in the G(1 phase have the highest potential to migrate. The molecular mechanism linking these two processes is not understood. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we explored the function of STK35L1, a novel Ser/Thr kinase, localized in the nucleus and nucleolus of endothelial cells. Molecular biological analysis identified a bipartite nuclear localization signal, and nucleolar localization sequences in the N-terminal part of STK35L1. Nuclear actin was identified as a novel binding partner of STK35L1. A class III PDZ binding domains motif was identified in STK35L1 that mediated its interaction with actin. Depletion of STK35L1 by siRNA lead to an accelerated G(1 to S phase transition after serum-stimulation of endothelial cells indicating an inhibitory role of the kinase in G(1 to S phase progression. Cell cycle specific genes array analysis revealed that one gene was prominently downregulated (8.8 fold in STK35L1 silenced cells: CDKN2A alpha transcript, which codes for p16(INK4a leading to G(1 arrest by inhibition of CDK4/6. Moreover in endothelial cells seeded on Matrigel, STK35L1 expression was rapidly upregulated, and silencing of STK35L1 drastically inhibited endothelial sprouting that is required for angiogenesis. Furthermore, STK35L1 depletion profoundly impaired endothelial cell migration in two wound healing assays. CONCLUSION/SIGNIFICANCE: The results indicate that by regulating CDKN2A and inhibiting G1- to S-phase transition STK35L1 may act as a central kinase linking the cell cycle and migration of endothelial cells. The interaction of STK35L1 with nuclear

  11. Features of single and double ionization processes induced by few cycle laser pulses

    International Nuclear Information System (INIS)

    Starace, A.F.

    2005-01-01

    Full text: The advent of laser pulses with attosecond pulse lengths ushers in the regime of few cycle laser pulse interactions with atoms and ions, including the interesting cases of single and half cycle laser pulses. In this talk I will present results of recent studies of single electron ionization/detachment and double electron ionization/detachment produced by a few cycle laser pulse. For the former case, we shall demonstrate that the ionized/detached electron momentum distribution reflects the interference of electron probability wave packets produced by each half cycle of a single cycle pulse. Also, that the ionized/detached electron momentum distribution uniquely characterizes the phase of the single cycle laser pulse within the laser pulse envelope. Regarding double ionization/detachment, our numerical experiments have shown that single cycle and double half cycle pulses produce different electron angular distributions. Some double ionization features that are present only in the single cycle case can only have been produced by electron impact ionization during rescattering of an initially ionized electron and thus represent a sensitive measure of the rescattering process. Refs. 2 (author)

  12. A model describing water and salt migration in concrete during wetting/drying cycles

    NARCIS (Netherlands)

    Arends, T.; Taher, A.; van der Zanden, A.J.J.; Brouwers, H.J.H.; Bilek, V.; Kersner, Z.

    2014-01-01

    In order to predict the life span of concrete structures, models describing the migration of chloride are needed. In this paper, a start is made with a simple, theoretical model describing water and chloride transport in a concrete sample. First, transport of water in concrete is considered with

  13. Validity of single-cycle objective functions for multicycle reload design optimization

    International Nuclear Information System (INIS)

    Kropaczek, D.J.; McElroy, J.; Turinsky, P.J.

    1993-01-01

    Beyond the equilibrium cycle scoping calculations used for determining numbers of feed assemblies and enrichment estimates, multicycle reload design currently consists of stagewise optimization of single-cycle core loading patterns, typically extending over a short-term planning horizon of perhaps three reload cycles. Particularly in transition cycles, however, optimizing a loading pattern over a single cycle for a stated objective, such as minimum core leakage, may have an adverse impact on subsequent cycles. The penalties paid may be in the form of reduced thermal margin or an increase in feed enrichment due to insufficient reactivity carryover from the open-quotes optimizedclose quotes cycle. In view of current practices, a study was performed that examined the behavior of the loading pattern as a function of the objective functions selected as implemented in the stagewise optimization of single-cycle core loading patterns from initial transition cycle through equilibrium using the FORMOSA-P code. The objective functions studied were region average discharge burnup maximization (with enrichment search) and feed enrichment minimization. It is noted at the beginning that the maximization of region average discharge has no meaning for the equilibrium cycle because region average discharge burnup is explicitly set by the feed size and cycle length independent of the loading pattern. In the nonequilibrium cycle, however, it was reasoned that this objective would provide the maximum reactivity carryover throughout the transition and thus have a direct effect on minimizing the multicycle levelized fuel cost

  14. Biogeochemical cycles of Chernobyl-born radionuclides in the contaminated forest ecosystems: long-term dynamics of the migration processes

    Science.gov (United States)

    Shcheglov, Alexey; Tsvetnova, Ol'ga; Klyashtorin, Alexey

    2013-04-01

    Biogeochemical migration is a dominant factor of the radionuclide transport through the biosphere. In the early XX century, V.I. Vernadskii, a Russian scientist known, noted about a special role living things play in transport and accumulation of natural radionuclide in various environments. The role of biogeochemical processes in migration and redistribution of technogenic radionuclides is not less important. In Russia, V. M. Klechkovskii and N.V. Timofeev-Ressovskii showed some important biogeochemical aspects of radionuclide migration by the example of global fallout and Kyshtym accident. Their followers, R.M. Alexakhin, M.A. Naryshkin, N.V. Kulikov, F.A. Tikhomirov, E.B. Tyuryukanova, and others also contributed a lot to biogeochemistry of radionuclides. In the post-Chernobyl period, this area of knowledge received a lot of data that allowed building the radioactive element balance and flux estimation in various biogeochemical cycles [Shcheglov et al., 1999]. Regrettably, many of recent radioecological studies are only focused on specific radionuclide fluxes or pursue some applied tasks, missing the holistic approach. Most of the studies consider biogeochemical fluxes of radioactive isotopes in terms of either dose estimation or radionuclide migration rates in various food chains. However, to get a comprehensive picture and develop a reliable forecast of environmental, ecological, and social consequences of radioactive pollution in a vast contaminated area, it is necessary to investigate all the radionuclide fluxes associated with the biogeochemical cycles in affected ecosystems. We believe such an integrated approach would be useful to study long-term environmental consequences of the Fukushima accident as well. In our long-term research, we tried to characterize the flux dynamics of the Chernobyl-born radionuclides in the contaminated forest ecosystems and landscapes as a part of the integrated biogeochemical process. Our field studies were started in June of

  15. Recruitment of single muscle fibers during submaximal cycling exercise

    NARCIS (Netherlands)

    Altenburg, T.M.; Degens, H.; van Mechelen, W.; Sargeant, A.J.; de Haan, A.

    2007-01-01

    In literature, an inconsistency exists in the submaximal exercise intensity at which type II fibers are activated. In the present study, the recruitment of type I and II fibers was investigated from the very beginning and throughout a 45-min cycle exercise at 75% of the maximal oxygen uptake, which

  16. Kink structures induced in nickel-based single crystal superalloys by high-Z element migration

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Fei; Zhang, Jianxin [Key Laboratory for Liquid Structure and Heredity of Materials, Ministry of Education, Shandong University, Jinan 250061 (China); Mao, Shengcheng [Institute of Microstructure and Property of Advanced Materials, Beijing University of Technology, Beijing 100124 (China); Jiang, Ying [Center of Electron Microscopy and State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027 (China); Feng, Qiang [National Center for Materials Service Safety, University of Science and Technology Beijing, Beijing 100083 (China); State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083 (China); Shen, Zhenju; Li, Jixue; Zhang, Ze [Center of Electron Microscopy and State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027 (China); Han, Xiaodong [Institute of Microstructure and Property of Advanced Materials, Beijing University of Technology, Beijing 100124 (China)

    2015-01-05

    Highlights: • Innovative kink structures generate at the γ/γ′ interfaces in the crept superalloy. • Clusters of heavy elements congregate at the apex of the kinks. • Dislocation core absorbs hexagonal structural high-Z elements. - Abstract: Here, we investigate a new type of kink structure that is found at γ/γ′ interfaces in nickel-based single crystal superalloys. We studied these structures at the atomic and elemental level using aberration corrected high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM). The core of the dislocation absorbs high-Z elements (i.e., Co and Re) that adopt hexagonal arrangements, and it extrudes elements (i.e., Ni and Al) that adopt face centered cubic (fcc) structures. High-Z elements (i.e., Ta and W) and Cr, which is a low-Z element, are stabilized in body centered cubic (bcc) arrangements; Cr tends to behave like Re. High-Z elements, which migrate and adopt a hexagonal structure, induce kink formation at γ/γ′ interfaces. This process must be analyzed to fully understand the kinetics and dynamics of creep in nickel-based single crystal superalloys.

  17. Adhesion and migration of CHO cells on micropatterned single layer graphene

    Science.gov (United States)

    Keshavan, S.; Oropesa-Nuñez, R.; Diaspro, A.; Canale, C.; Dante, S.

    2017-06-01

    Cell patterning technology on single layer graphene (SLG) is a fairly new field that can find applications in tissue engineering and biomaterial/biosensors development. Recently, we have developed a simple and effective approach for the fabrication of patterned SLG substrates by laser micromachining, and we have successfully applied it for the obtainment of geometrically ordered neural networks. Here, we exploit the same approach to investigate the generalization of the cell response to the surface cues of the fabricated substrates and, contextually, to quantify cell adhesion on the different areas of the patterns. To attain this goal, we tested Chinese hamster ovary (CHO) cells on PDL-coated micropatterned SLG substrates and quantified the adhesion by using single cell force spectroscopy (SCFS). Our results indicate higher cell adhesion on PDL-SLG, and, consequently, an initial CHO cell accumulation on the graphene areas, confirming the neuronal behaviour observed previously; interestingly, at later time point in culture, cell migration was observed towards the adjacent SLG ablated regions, which resulted more favourable for cell proliferation. Therefore, our findings indicate that the mechanism of interaction with the surface cues offered by the micropatterned substrates is strictly cell-type dependent.

  18. Efficiency of single-family houses and harmonisation of their life cycle participants’ interests

    Directory of Open Access Journals (Sweden)

    Nerija Kvederyte

    2000-01-01

    Full Text Available An efficient single-family house is the main purpose of the life cycle. It determines the necessity to evaluate various decisions of the life cycle of single-family houses and possibilities to satisfy objectives and requirements of the participants of that process. To design and achieve an effective process of the life cycle of a single-family house, it is necessary to take care of its efficiency starting from the determination of needs and objectives and ending with the usage of a building.

  19. Fibronectin Modulates Cell Adhesion and Signaling to Promote Single Cell Migration of Highly Invasive Oral Squamous Cell Carcinoma

    Science.gov (United States)

    Ramos, Grasieli de Oliveira; Bernardi, Lisiane; Lauxen, Isabel; Sant’Ana Filho, Manoel; Horwitz, Alan Rick; Lamers, Marcelo Lazzaron

    2016-01-01

    Cell migration is regulated by adhesion to the extracellular matrix (ECM) through integrins and activation of small RhoGTPases, such as RhoA and Rac1, resulting in changes to actomyosin organization. During invasion, epithelial-derived tumor cells switch from laminin-enriched basal membrane to collagen and fibronectin-enriched connective tissue. How this switch affects the tumor migration is still unclear. We tested the hypothesis that ECM dictates the invasiveness of Oral Squamous Cell Carcinoma (OSCC). We analyzed the migratory properties of two OSCC lines, a low invasive cell line with high e-cadherin levels (Linv/HE-cad) or a highly invasive cell line with low e-cadherin levels (Hinv/LE-cad), plated on different ECM components. Compared to laminin, fibronectin induced non-directional collective migration and decreased RhoA activity in Linv/HE-cad OSCC. For Hinv/LE-cad OSCC, fibronectin increased Rac1 activity and induced smaller adhesions, resulting in a fast single cell migration in both 2D and 3D environments. Consistent with these observations, human OSCC biopsies exhibited similar changes in cell-ECM adhesion distribution at the invasive front of the tumor, where cells encounter fibronectin. Our results indicate that ECM composition might induce a switch from collective to single cell migration according to tumor invasiveness due to changes in cell-ECM adhesion and the resulting signaling pathways that alter actomyosin organization. PMID:26978651

  20. Fibronectin Modulates Cell Adhesion and Signaling to Promote Single Cell Migration of Highly Invasive Oral Squamous Cell Carcinoma.

    Directory of Open Access Journals (Sweden)

    Grasieli de Oliveira Ramos

    Full Text Available Cell migration is regulated by adhesion to the extracellular matrix (ECM through integrins and activation of small RhoGTPases, such as RhoA and Rac1, resulting in changes to actomyosin organization. During invasion, epithelial-derived tumor cells switch from laminin-enriched basal membrane to collagen and fibronectin-enriched connective tissue. How this switch affects the tumor migration is still unclear. We tested the hypothesis that ECM dictates the invasiveness of Oral Squamous Cell Carcinoma (OSCC. We analyzed the migratory properties of two OSCC lines, a low invasive cell line with high e-cadherin levels (Linv/HE-cad or a highly invasive cell line with low e-cadherin levels (Hinv/LE-cad, plated on different ECM components. Compared to laminin, fibronectin induced non-directional collective migration and decreased RhoA activity in Linv/HE-cad OSCC. For Hinv/LE-cad OSCC, fibronectin increased Rac1 activity and induced smaller adhesions, resulting in a fast single cell migration in both 2D and 3D environments. Consistent with these observations, human OSCC biopsies exhibited similar changes in cell-ECM adhesion distribution at the invasive front of the tumor, where cells encounter fibronectin. Our results indicate that ECM composition might induce a switch from collective to single cell migration according to tumor invasiveness due to changes in cell-ECM adhesion and the resulting signaling pathways that alter actomyosin organization.

  1. The International intraval project. Phase 1 case 2. Radionuclide migration in single natural fractures in granite

    International Nuclear Information System (INIS)

    Skagius, K.

    1992-01-01

    The INTRAVAL study addresses validation of geosphere transport models for use in repository performance assessment by examining various test cases relevant to radioactive waste disposal. This report describes the results from INTRAVAL test case 2 which is based on a set of laboratory experiments studying migration of non-sorbing as well as sorbing tracers in a single fracture in granitic cores. Three project teams have investigated this test case. Models including advection, dispersion, sorption to the fracture surface, matrix diffusion and sorption within the rock matrix were calibrated against the experimental breakthrough curves. Obtained best-fit values of the parameters determining the interaction between tracer and rock were in fair agreement with independently measured data. Models neglecting matrix diffusion and sorption within the rock matrix gave poor fits to the experimental data. These results suggest the need to include matrix diffusion and matrix sorption in the model to represent data for this test case. Furthermore, it was not possible to distinguish between hydrodynamic dispersion and channelling dispersion since equally good fits were obtained with both models. Equally good fits were also obtained with models assuming constant fracture aperture and variable fracture aperture. In the context of performance assessment of repositories in fractured rock, the major outcome from this test case is additional support for the inclusion of matrix diffusion and matrix sorption in the transport models. 17 refs., 14 figs., 3 tabs

  2. Development of a Hemispherical Metal Diaphragm for Single-Cycle Liquid-Metal Positive Expulsion Systems

    National Research Council Canada - National Science Library

    Gorland, Sol

    1965-01-01

    This report presents experimental results pertaining to the design and development of a metallic expulsion diaphragm for single-cycle positive expulsion of high-temperature liquid in an agravity condition...

  3. Why Migrate: For Study or for Work?

    Directory of Open Access Journals (Sweden)

    Elise S. Brezis

    2016-08-01

    Full Text Available Over the past decades, globalization has led to a huge increase in the migration of workers, as well as students. This paper develops a simple two-step model that describes the decisions of an individual vis-à-vis education and migration, and presents a unified model, wherein the two migration decisions are combined into a single, unique model. This paper shows that under the plausible assumption that costs of migration differ over the human life cycle, the usual brain drain strategy is sub-optimal. With an increase in globalization, the brain drain strategy will be replaced by the strategy of migration of students.

  4. Analysis of changes in paper cutting forces during the cutting cycle in single-knife guillotine

    OpenAIRE

    Rusin, Agnieszka; Petriaszwili, Georgij

    2013-01-01

    Paper presents the results of changes in the three components of cutting forces of paper stacks cutting during the cutting cycle in single-knife guillotine. The changes of the three components of cutting force at different stages of cutting cycle were analyzed.

  5. Migration and clinical outcome of mobile-bearing versus fixed-bearing single-radius total knee arthroplasty.

    Science.gov (United States)

    Van Hamersveld, Koen T; Marang-Van De Mheen, Perla J; Van Der Heide, Huub J L; Van Der Linden-Van Der Zwaag, Henrica M J; Valstar, Edward R; Nelissen, Rob G H H

    2018-04-01

    Background and purpose - Mobile-bearing total knee prostheses (TKPs) were developed in the 1970s in an attempt to increase function and improve implant longevity. However, modern fixed-bearing designs like the single-radius TKP may provide similar advantages. We compared tibial component migration measured with radiostereometric analysis (RSA) and clinical outcome of otherwise similarly designed cemented fixed-bearing and mobile-bearing single-radius TKPs. Patients and methods - RSA measurements and clinical scores were assessed in 46 randomized patients at baseline, 6 months, 1 year, and annually thereafter up to 6 years postoperatively. A linear mixed-effects model was used to analyze the repeated measurements. Results - Both groups showed comparable migration (p = 0.3), with a mean migration at 6-year follow-up of 0.90 mm (95% CI 0.49-1.41) for the fixed-bearing group compared with 1.22 mm (95% CI 0.75-1.80) for the mobile-bearing group. Clinical outcomes were similar between groups. 1 fixed-bearing knee was revised for aseptic loosening after 6 years and 2 knees (1 in each group) were revised for late infection. 2 knees (1 in each group) were suspected for loosening due to excessive migration. Another mobile-bearing knee was revised after an insert dislocation due to failure of the locking mechanism 6 weeks postoperatively, after which study inclusion was preliminary terminated. Interpretation - Fixed-bearing and mobile-bearing single-radius TKPs showed similar migration. The latter may, however, expose patients to more complex surgical techniques and risks such as insert dislocations inherent to this rotating-platform design.

  6. Dual capillary tube / heat exchanger in combination with cycle priming for reducing charge migration

    Science.gov (United States)

    Gomes, Alberto Regio; Kuehl, Steven J.; Litch, Andrew D.; Wu, Guolian

    2017-07-04

    A refrigerator appliance including a multi-capacity compressor and a refrigerant circuit with two conduits and pressure reducing devices arranged in parallel between an evaporator and a condenser. Refrigerant can flow through one, both or none of the conduits and pressure reducing devices. The appliance also has a heat exchanger in contact with either one pressure reducing device, or one conduit between the pressure reducing device and the valve system. The appliance also includes a controller for priming the compressor above a nominal capacity for a predetermined or calculated duration at the beginning of an ON-cycle.

  7. Manipulating Ion Migration for Highly Stable Light-Emitting Diodes with Single-Crystalline Organometal Halide Perovskite Microplatelets.

    Science.gov (United States)

    Chen, Mingming; Shan, Xin; Geske, Thomas; Li, Junqiang; Yu, Zhibin

    2017-06-27

    Ion migration has been commonly observed as a detrimental phenomenon in organometal halide perovskite semiconductors, causing the measurement hysteresis in solar cells and ultrashort operation lifetimes in light-emitting diodes. In this work, ion migration is utilized for the formation of a p-i-n junction at ambient temperature in single-crystalline organometal halide perovskites. The junction is subsequently stabilized by quenching the ionic movement at a low temperature. Such a strategy of manipulating the ion migration has led to efficient single-crystalline light-emitting diodes that emit 2.3 eV photons starting at 1.8 V and sustain a continuous operation for 54 h at ∼5000 cd m -2 without degradation of brightness. In addition, a whispering-gallery-mode cavity and exciton-exciton interaction in the perovskite microplatelets have both been observed that can be potentially useful for achieving electrically driven laser diodes based on single-crystalline organometal halide perovskite semiconductors.

  8. Local ecological knowledge of fishers about the life cycle and temporal patterns in the migration of mullet (Mugil liza in Southern Brazil

    Directory of Open Access Journals (Sweden)

    Dannieli Firme Herbst

    Full Text Available This research investigates local ecological knowledge of fishers in communities along a latitudinal gradient in the coast of the Santa Catarina State, regarding the life cycle of mullets Mugil liza (migration, feeding, and reproductive behavior. Our sampling encompassed eight Santa Catarina coastal cities (nine artisanal fishing sites and engaged 45 key informants (28- 86 years of age through semi-structured interviews from August/2011 to March/2012. This fish species feeds and grows in lagoon and estuarine systems, migrating to the sea for reproduction, and spawning. Fishers acknowledged the Patos Lagoon and the Plata River as the main source of mullet schools. Migration occurs from South to North and the routes vary according to climatic and oceanographic conditions (e.g., low temperatures, south winds, rainfall, currents, salinity. These conditions influence the abundance of mullets (and therefore fisheries success, their migration and stops in locations such as beaches, rocky shores, and islands. According to fishers, mullet spawning occurs throughout the coast of the Santa Catarina State and they feed in lagoons and riverine systems but also out at sea during migration. In conclusion, fishers possess a detailed knowledge about mullet life cycle and they identify intra and interannual variations in migration routes, a pattern that should be considered in managing the fishery.

  9. Influence of climate cycles on grapevine domestication and ancient migrations in Eurasia.

    Science.gov (United States)

    Mariani, Luigi; Cola, Gabriele; Maghradze, David; Failla, Osvaldo; Zavatti, Franco

    2018-09-01

    The objective of this work is to investigate the Holocenic climate cycles that may have influenced the domestication of grapevine in the Subcaucasian area and its subsequent spread in Eurasia. The analysis covered the longitudinal belt ranging from the Iberian Peninsula to Japan, seen as the preferential pathway for the Holocenic spread of grapevine and many other crops in Eurasia. Spectral analysis was considered as the criterion of investigation and the Holocenic cycles were analyzed considering different geochemical and biological proxies, of which seven are directly referred to vine. In this context the relation of the abovementioned proxies with spectral peaks of possible causal factors like Solar activity (SA), North Atlantic oceanic factors (Atlantic Multidecadal Oscillation - AMO and North Atlantic Oscillation - NAO), and subtropical oceanic factors (El Nino Southern Oscillation - ENSO) was also analyzed. In order to acquire a sufficiently wide number of proxies sensitive to the causal factors, we referred to a latitudinal belt wider than the one colonized by vine, also acquiring proxy from the Scandinavian area, notoriously susceptible to North Atlantic forcings. The analysis of the proxy spectral peaks, considering 20 classes with a 50-years step in the 0-1000 years range, showed that the 50% of the classes have a higher frequency of peaks at East than West, the 20% a higher frequency at West than East and the 10% an equal frequency, showing the efficiency of the propagation of Western signals towards the center of Eurasia. The search of the causal factors spectral peaks in the proxy series showed that AMO, NAO and SA acted with a certain regularity on the entire belt investigated both latitudinally and longitudinally, while spectral peaks linked to ENSO underwent a considerable attenuation moving northward. Finally, the specific analysis on viticultural proxies showed common peaks with causal factors. Copyright © 2018 Elsevier B.V. All rights reserved.

  10. A novel spiroindoline targets cell cycle and migration via modulation of microtubule cytoskeleton.

    Science.gov (United States)

    Kumar, Naveen; Hati, Santanu; Munshi, Parthapratim; Sen, Subhabrata; Sehrawat, Seema; Singh, Shailja

    2017-05-01

    Natural product-inspired libraries of molecules with diverse architectures have evolved as one of the most useful tools for discovering lead molecules for drug discovery. In comparison to conventional combinatorial libraries, these molecules have been inferred to perform better in phenotypic screening against complicated targets. Diversity-oriented synthesis (DOS) is a forward directional strategy to access such multifaceted library of molecules. From a successful DOS campaign of a natural product-inspired library, recently a small molecule with spiroindoline motif was identified as a potent anti-breast cancer compound. Herein we report the subcellular studies performed for this molecule on breast cancer cells. Our investigation revealed that it repositions microtubule cytoskeleton and displaces AKAP9 located at the microtubule organization centre. DNA ladder assay and cell cycle experiments further established the molecule as an apoptotic agent. This work further substantiated the amalgamation of DOS-phenotypic screening-sub-cellular studies as a consolidated blueprint for the discovery of potential pharmaceutical drug candidates.

  11. Weighting and Aggregation in Life Cycle Assessment: Do Present Aggregated Single Scores Provide Correct Decision Support?

    DEFF Research Database (Denmark)

    Kalbar, Pradip; Birkved, Morten; Nygaard, Simon Elsborg

    2016-01-01

    This study investigates the prevailing practice of obtaining single scores in life cycle assessment (LCA) and identifies potential lacunas in impact assessment methodology related to the results of aggregation into endpoints and single scores. In order to conduct this investigation, a detailed...... approach was adopted to facilitate identification of three main problems related to the single-score calculation approach. The prevailing ReCiPe single-score calculation method does not account for either the effect of so-called dominating alternatives (i.e., alternatives having high values across all...

  12. Self-phase modulation of a single-cycle THz pulse

    DEFF Research Database (Denmark)

    Turchinovich, Dmitry; Hvam, Jørn Märcher; Hoffmann, M. C.

    2013-01-01

    We demonstrate self-phase modulation (SPM) of a single-cycle THz pulse in a semiconductor, using bulk n-GaAs as a model system. The SPM arises from the heating of free electrons in the electric field of the THz pulse. Electron heating leads to an ultrafast reduction of the plasma frequency, which...... results in a strong modification of the THz-range dielectric function of the material. THz SPM is observed directly in the time domain as a characteristic reshaping of single-cycle THz pulse. In the frequency domain, it corresponds to a strong frequency-dependent refractive index nonlinearity of n...

  13. Direct Observation of Halide Migration and its Effect on the Photoluminescence of Methylammonium Lead Bromide Perovskite Single Crystals.

    Science.gov (United States)

    Luo, Yanqi; Khoram, Parisa; Brittman, Sarah; Zhu, Zhuoying; Lai, Barry; Ong, Shyue Ping; Garnett, Erik C; Fenning, David P

    2017-11-01

    Optoelectronic devices based on hybrid perovskites have demonstrated outstanding performance within a few years of intense study. However, commercialization of these devices requires barriers to their development to be overcome, such as their chemical instability under operating conditions. To investigate this instability and its consequences, the electric field applied to single crystals of methylammonium lead bromide (CH 3 NH 3 PbBr 3 ) is varied, and changes are mapped in both their elemental composition and photoluminescence. Synchrotron-based nanoprobe X-ray fluorescence (nano-XRF) with 250 nm resolution reveals quasi-reversible field-assisted halide migration, with corresponding changes in photoluminescence. It is observed that higher local bromide concentration is correlated to superior optoelectronic performance in CH 3 NH 3 PbBr 3 . A lower limit on the electromigration rate is calculated from these experiments and the motion is interpreted as vacancy-mediated migration based on nudged elastic band density functional theory (DFT) simulations. The XRF mapping data provide direct evidence of field-assisted ionic migration in a model hybrid-perovskite thin single crystal, while the link with photoluminescence proves that the halide stoichiometry plays a key role in the optoelectronic properties of the perovskite. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. The Role of Migration and Single Motherhood in Upper Secondary Education in Mexico

    Science.gov (United States)

    Creighton, Mathew J.; Park, Hyunjoon; Teruel, Graciela M.

    2009-01-01

    We investigated the link between migration, family structure, and the risk of dropping out of upper secondary school in Mexico. Using two waves of the Mexican Family Life Survey, which includes 1,080 upper secondary students, we longitudinally modeled the role of family structure in the subsequent risk of dropping out, focusing on the role of…

  15. The effects of single-walled carbon nanotubes on cancer cell migration using a pancreatic tumor model

    Science.gov (United States)

    Layton, Elivia; McNamar, Rachel; Hasanjee, Aamr M.; McNair, Cayman; Stevens, Brianna; Vaughan, Melville; Zhou, Feifan; Chen, Wei R.

    2017-02-01

    Non-invasive laser immunotherapy (NLIT) is a viable alternative to traditional cancer treatment because it combines the photothermal and immunological effects of non-invasive laser irradiation and single-walled carbon nanotubes (SWNT) with an immunoadjuvant, glycated chitosan (GC). This combination forms SWNT-GC, a photosensitive immunoadjuvant, which creates a tumor-specific immunity that targets both the primary tumor and any metastasis. It is known that NLIT induces anti-tumor as well as anti-metastatic immune responses, but its immunological mechanism is not clear. The objective of this study is to clarify the role of SWNT-GC in cancer cell migration. Panc02 (non-metastatic) and Panc02-H7 (metastatic) pancreatic cancer cells were used in two-dimensional elastomer plug assays to observe the restriction of cell migration induced by SWNT, GC, and SWNT-GC individually. To replicate a three-dimensional in vivo study, a similar assay was repeated using embedded collagen lattices. Both the 2D and the 3D studies confirmed previous results indicating that GC inhibits cancer cell motility. The 2D and 3D studies also showed that SWNT-GC inhibited the migration of cancer cells, but a discrepancy was observed regarding the effect of SWNT alone. The 2D model concluded that SWNT inhibited migration while the 3D model determined that SWNT promoted migration. The results of this study will guide future work to determine the mechanism behind NLIT, including how metastases are eradicated and how the tumor specific immunity is created.

  16. Latent Membrane Protein 1 as a molecular adjuvant for single-cycle lentiviral vaccines

    Directory of Open Access Journals (Sweden)

    Rahmberg Andrew R

    2011-05-01

    Full Text Available Abstract Background Molecular adjuvants are a promising method to enhance virus-specific immune responses and protect against HIV-1 infection. Immune activation by ligands for receptors such as CD40 can induce dendritic cell activation and maturation. Here we explore the incorporation of two CD40 mimics, Epstein Barr Virus gene LMP1 or an LMP1-CD40 chimera, into a strain of SIV that was engineered to be limited to a single cycle of infection. Results Full length LMP1 or the chimeric protein LMP1-CD40 was cloned into the nef-locus of single-cycle SIV. Human and Macaque monocyte derived macrophages and DC were infected with these viruses. Infected cells were analyzed for activation surface markers by flow cytometry. Cells were also analyzed for secretion of pro-inflammatory cytokines IL-1β, IL-6, IL-8, IL-12p70 and TNF by cytometric bead array. Conclusions Overall, single-cycle SIV expressing LMP1 and LMP1-CD40 produced a broad and potent TH1-biased immune response in human as well as rhesus macaque macrophages and DC when compared with control virus. Single-cycle SIV-LMP1 also enhanced antigen presentation by lentiviral vector vaccines, suggesting that LMP1-mediated immune activation may enhance lentiviral vector vaccines against HIV-1.

  17. POLITICAL MONETARY CYCLES IN COALITION AND SINGLE PARTY GOVERNMENT PERIODS: A CASE STUDY ON TURKEY

    Directory of Open Access Journals (Sweden)

    AHMET EMRAH TAYYAR

    2017-12-01

    Full Text Available According to the theory of political monetary cycles, the government manipulates monetary policy during election periods in order to be re-elected. According to the said theory, expansionary monetary policies are implemented before the elections with opportunistic objective, while the contractionary monetary policies are implemented to stabilize the economy immediately after the elections. The use of monetary policy instruments for political purposes depends on the presence of a non-autonomous central bank, flexible exchange rate regime in the country, and the coordination between fiscal and monetary policies. Thus, the changes in the monetary policy indicators in election periods during coalition and single party governments in Turkey between 1990 and 2016 were examined in the present study. The money in circulation (M0, M1 money supply, domestic loans and inflation series were analyzed with the seasonal Box-Jenkins method for the above mentioned periods. Based on the findings of the study, political monetary cycles were not observed during the 1990-2000 coalition governments. It was determined that there were political monetary cycles during the single party government period between 2000 and 2016.Furthermore, although it could be expected that the political monetary cycles would be removed with the liberalization of the Turkish central bank on 25 April 2001, the existence of political monetary cycles during the period of 2000-2016 indicates that central bank independence was not fully achieved in Turkey. Based on another finding of the present study, the lack of political monetary cycles during the coalition government periods could lead to the failure in financing the budget deficit that increase due to political reasons with monetary policies. However, due to the existence of political monetary cycles during the single party government period, it could be argued that politically induced budget deficits changed in consistence with the

  18. Simplified nuclear fuel reprocessing flowsheet: a single-cycle Purex process

    International Nuclear Information System (INIS)

    Montuir, M.; Dinh, B.; Baron, P.

    2004-01-01

    A simplified flowsheet with only one purification cycle instead of three is proposed for reprocessing spent nuclear fuel using the Purex process. A single-cycle flowsheet minimizes the process equipment required, the number of control points before transfer between process units, and the solvent and effluent quantities. For the uranium stream, an alpha barrier is used to strip any residual contaminants (Np, Th, Pu) from the uranium-loaded solvent. This additional step eliminates the need for a second uranium cycle. For the plutonium stream, an additional βγ co-decontamination step and a higher plutonium concentration are required before the oxalate conversion step; a plutonium 'half-cycle' is added downstream. The unloaded solvent from this half-cycle is returned to the selective plutonium stripping step, allowing significant plutonium half-cycle losses. It should be possible to reduce the number of stages in the half-cycle extraction step by recycling the raffinate to the upstream separation process. (authors)

  19. A DANREF certified reference plastic for measurement of overall migration into the food simulant olive oil by single sided testing

    DEFF Research Database (Denmark)

    Lund, K. H.; Lillemark, L.; Petersen, Jens Højslev

    2000-01-01

    A reference material for the determination of overall migration from a plastic coextrudate into the fatty food simulant olive oil was produced and certified in an interlaboratory study. The analyses were carried out according to the ENV 1186 standard from the European Committee for Standardization...... (CEN) [1, 2, 3] with exposure of the coextrudate to olive oil for 10 days at 40 degrees C. After an initial preliminary interlaboratory study eight laboratories participated in the certification round, and two different methods were used to obtain single sided exposure of the plastic to the oil...

  20. Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk

    DEFF Research Database (Denmark)

    Goode, Ellen L; Fridley, Brooke L; Vierkant, Robert A

    2009-01-01

    Polymorphisms in genes critical to cell cycle control are outstanding candidates for association with ovarian cancer risk; numerous genes have been interrogated by multiple research groups using differing tagging single-nucleotide polymorphism (SNP) sets. To maximize information gleaned from......, and rs3212891; CDK2 rs2069391, rs2069414, and rs17528736; and CCNE1 rs3218036. These results exemplify the utility of imputation in candidate gene studies and lend evidence to a role of cell cycle genes in ovarian cancer etiology, suggest a reduced set of SNPs to target in additional cases and controls....

  1. Development of dynamic simulation code for fuel cycle of fusion reactor. 1. Single pulse operation simulation

    Energy Technology Data Exchange (ETDEWEB)

    Aoki, Isao; Seki, Yasushi [Japan Atomic Energy Research Inst., Naka, Ibaraki (Japan). Naka Fusion Research Establishment; Sasaki, Makoto; Shintani, Kiyonori; Kim, Yeong-Chan

    1997-11-01

    A dynamic simulation code for the fuel cycle of a fusion experimental reactor has been developed. The code follows the fuel inventory change with time in the plasma chamber and the fuel cycle system during a single pulse operation. The time dependence of the fuel inventory distribution is evaluated considering the fuel burn and exhaust in the plasma chamber, purification and supply functions. For each subsystem of the plasma chamber and the fuel cycle system, the fuel inventory equation is written based on the equation of state considering the function of fuel burn, exhaust, purification, and supply. The processing constants of subsystem for the steady states were taken from the values in the ITER Conceptual Design Activity (CDA) report. Using the code, the time dependence of the fuel supply and inventory depending on the burn state and subsystem processing functions are shown. (author)

  2. Pregnancy and neonatal outcomes following letrozole use in frozen-thawed single embryo transfer cycles.

    Science.gov (United States)

    Tatsumi, T; Jwa, S C; Kuwahara, A; Irahara, M; Kubota, T; Saito, H

    2017-06-01

    Are pregnancy and neonatal outcomes following letrozole use comparable with natural and HRT cycles in patients undergoing single frozen-thawed embryo transfer (FET)? Letrozole use was significantly associated with higher rates of clinical pregnancy, clinical pregnancy with fetal heart beat and live birth, and with a lower rate of miscarriage, compared with natural and HRT cycles. Letrozole is the most commonly used aromatase inhibitor for mild ovarian stimulation in ART. However, the effect of letrozole on pregnancy and neonatal outcomes in FET are not well known. A retrospective cohort study was conducted using data from the Japanese national ART registry between 2012 and 2013. A total of 110 722 single FET cycles with letrozole (n = 2409), natural (n = 41 470) or HRT cycles (n = 66 843) were included. The main outcomes were the rates of clinical pregnancy, clinical pregnancy with fetal heart beat, miscarriage and live birth. Adjusted odds ratios and relative risks (RRs) were calculated using a generalized estimating equation adjusting for correlations within clinics. The rates of clinical pregnancy, clinical pregnancy with fetal heart beat, and live birth were significantly higher, while the rate of miscarriage was significantly lower in the letrozole group compared with the natural and HRT groups. In blastocyst stage transfers, the adjusted RRs for clinical pregnancy with fetal heart beat of letrozole compared with natural and HRT cycles were 1.48 (95% CI: 1.41-1.55) and 1.62 (95% CI: 1.54-1.70), respectively. Similarly, the adjusted RRs of letrozole for miscarriage compared with natural and HRT cycles were 0.91 (95% CI: 0.88-0.93) and 0.84 (95% CI: 0.82-0.87), respectively. Neonatal outcomes were mostly similar in letrozole, natural and HRT cycles. Important limitations of this study included the lack of information concerning the reasons for selecting the specific FET method, parity, the number of previous ART failures, embryo quality and the dose and duration

  3. Semi-classical description of Rydberg atoms in strong, single-cycle electromagnetic pulses

    International Nuclear Information System (INIS)

    Jensen, R.V.; Sanders, M.M.

    1993-01-01

    Recent experimental measurements of the excitation and ionization of Rydberg atoms by single-cycle, electromagnetic pulses have revealed a variety of novel features. Because many quantum states are strongly coupled by the broadband radiation in the short pulse, the traditional methods of quantum mechanics are inadequate to account for the experimental results. We have therefore developed a semi-classical description of the interaction of both hydrogenic and non-hydrogenic atoms with single-cycle pulses of intense, electromagnetic radiation which is based on the strong correspondence theory of Percival and Richards. This theory, which was originally introduced for the description of strong atomic collisions, accounts for some of the surprising features of the experimental measurements and provides new predictions for future experimental studies

  4. Thermodynamic analysis of single-stage and multi-stage adsorption refrigeration cycles with activated carbon–ammonia working pair

    International Nuclear Information System (INIS)

    Xu, S.Z.; Wang, L.W.; Wang, R.Z.

    2016-01-01

    Highlights: • Activated carbon–ammonia multi-stage adsorption refrigerator was analyzed. • COP, exergetic efficiency and entropy production of cycles were calculated. • Single-stage cycle usually has the advantages of simple structure and high COP. • Multi-stage cycles adapt to critical conditions better than single-stage cycle. • Boundary conditions for choosing optimal cycle were summarized as tables. - Abstract: Activated carbon–ammonia multi-stage adsorption refrigeration cycle was analyzed in this article, which realized deep-freezing for evaporating temperature under −18 °C with heating source temperature much lower than 100 °C. Cycle mathematical models for single, two and three-stage cycles were established on the basis of thorough thermodynamic analysis. According to simulation results of thermodynamic evaluation indicators such as COP (coefficient of performance), exergetic efficiency and cycle entropy production, multi-stage cycle adapts to high condensing temperature, low evaporating temperature and low heating source temperature well. Proposed cycle with selected working pair can theoretically work under very severe conditions, such as −25 °C evaporating temperature, 40 °C condensing temperature, and 70 °C heating source temperature, but under these working conditions it has the drawback of low cycle adsorption quantity. It was found that both COP and exergetic efficiency are of great reference value in the choice of cycle, whereas entropy production is not so useful for cycle stage selection. Finally, the application boundary conditions of single-stage, two-stage, and three-stage cycles were summarized as tables according to the simulation results, which provides reference for choosing optimal cycle under different conditions.

  5. Tumour cells expressing single VEGF isoforms display distinct growth, survival and migration characteristics.

    Directory of Open Access Journals (Sweden)

    Chryso Kanthou

    Full Text Available Vascular endothelial growth factor-A (VEGF is produced by most cancer cells as multiple isoforms, which display distinct biological activities. VEGF plays an undisputed role in tumour growth, vascularisation and metastasis; nevertheless the functions of individual isoforms in these processes remain poorly understood. We investigated the effects of three main murine isoforms (VEGF188, 164 and 120 on tumour cell behaviour, using a panel of fibrosarcoma cells we developed that express them individually under endogenous promoter control. Fibrosarcomas expressing only VEGF188 (fs188 or wild type controls (fswt were typically mesenchymal, formed ruffles and displayed strong matrix-binding activity. VEGF164- and VEGF120-producing cells (fs164 and fs120 respectively were less typically mesenchymal, lacked ruffles but formed abundant cell-cell contacts. On 3D collagen, fs188 cells remained mesenchymal while fs164 and fs120 cells adopted rounded/amoeboid and a mix of rounded and elongated morphologies respectively. Consistent with their mesenchymal characteristics, fs188 cells migrated significantly faster than fs164 or fs120 cells on 2D surfaces while contractility inhibitors accelerated fs164 and fs120 cell migration. VEGF164/VEGF120 expression correlated with faster proliferation rates and lower levels of spontaneous apoptosis than VEGF188 expression. Nevertheless, VEGF188 was associated with constitutively active/phosphorylated AKT, ERK1/2 and Stat3 proteins. Differences in proliferation rates and apoptosis could be explained by defective signalling downstream of pAKT to FOXO and GSK3 in fs188 and fswt cells, which also correlated with p27/p21 cyclin-dependent kinase inhibitor over-expression. All cells expressed tyrosine kinase VEGF receptors, but these were not active/activatable suggesting that inherent differences between the cell lines are governed by endogenous VEGF isoform expression through complex interactions that are independent of tyrosine

  6. CO Reduction to CH3OSiMe3: Electrophile-Promoted Hydride Migration at a Single Fe Site.

    Science.gov (United States)

    Deegan, Meaghan M; Peters, Jonas C

    2017-02-22

    One of the major challenges associated with developing molecular Fischer-Tropsch catalysts is the design of systems that promote the formation of C-H bonds from H 2 and CO while also facilitating the release of the resulting CO-derived organic products. To this end, we describe the synthesis of reduced iron-hydride/carbonyl complexes that enable an electrophile-promoted hydride migration process, resulting in the reduction of coordinated CO to a siloxymethyl (L n Fe-CH 2 OSiMe 3 ) group. Intramolecular hydride-to-CO migrations are extremely rare, and to our knowledge the system described herein is the first example where such a process can be accessed from a thermally stable M(CO)(H) complex. Further addition of H 2 to L n Fe-CH 2 OSiMe 3 releases CH 3 OSiMe 3 , demonstrating net four-electron reduction of CO to CH 3 OSiMe 3 at a single Fe site.

  7. Adsorption and migration of single metal atoms on the calcite (10.4) surface

    International Nuclear Information System (INIS)

    Pinto, H; Haapasilta, V; Lokhandwala, M; Foster, Adam S; Öberg, S

    2017-01-01

    Transition metal atoms are one of the key ingredients in the formation of functional 2D metal organic coordination networks. Additionally, the co-deposition of metal atoms can play an important role in anchoring the molecular structures to the surface at room temperature. To gain control of such processes requires the understanding of adsorption and diffusion properties of the different transition metals on the target surface. Here, we used density functional theory to investigate the adsorption of 3 d (Ti, Cr, Fe, Ni, Cu), 4 d (Zr, Nb, Mo, Pd, Ag) and 5 d (Hf, W, Ir, Pt, Au) transition metal adatoms on the insulating calcite (10.4) surface. We identified the most stable adsorption sites and calculated binding energies and corresponding ground state structures. We find that the preferential adsorption sites are the Ca–Ca bridge sites. Apart from the Cr, Mo, Cu, Ag and Au all the studied metals bind strongly to the calcite surface. The calculated migration barriers for the representative Ag and Fe atoms indicates that the metal adatoms are mobile on the calcite surface at room temperature. Bader analysis suggests that there is no significant charge transfer between the metal adatoms and the calcite surface. (paper)

  8. Migrating Multi-page Web Applications to Single-page AJAX Interfaces

    NARCIS (Netherlands)

    Mesbah, A.; Van Deursen, A.

    2006-01-01

    Recently, a new web development technique for creating interactive web applications, dubbed AJAX, has emerged. In this new model, the single-page web interface is composed of individual components which can be updated/replaced independently. With the rise of AJAX web applications classical

  9. Kinematics and early migration in single-radius mobile- and fixed-bearing total knee prostheses

    NARCIS (Netherlands)

    Wolterbeek, N.; Garling, E.H.; Mertens, B.J.; Nelissen, R.G.H.H.; Valstar, E.R.

    2012-01-01

    Background The mobile-bearing variant of a single-radius design is assumed to provide more freedom of motion compared to the fixed-bearing variant because the insert does not restrict the natural movements of the femoral component. This would reduce the contact stresses and wear which in turn may

  10. Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma

    Directory of Open Access Journals (Sweden)

    Spyros Darmanis

    2017-10-01

    Full Text Available Summary: Glioblastoma (GBM is the most common primary brain cancer in adults and is notoriously difficult to treat because of its diffuse nature. We performed single-cell RNA sequencing (RNA-seq on 3,589 cells in a cohort of four patients. We obtained cells from the tumor core as well as surrounding peripheral tissue. Our analysis revealed cellular variation in the tumor’s genome and transcriptome. We were also able to identify infiltrating neoplastic cells in regions peripheral to the core lesions. Despite the existence of significant heterogeneity among neoplastic cells, we found that infiltrating GBM cells share a consistent gene signature between patients, suggesting a common mechanism of infiltration. Additionally, in investigating the immunological response to the tumors, we found transcriptionally distinct myeloid cell populations residing in the tumor core and the surrounding peritumoral space. Our data provide a detailed dissection of GBM cell types, revealing an abundance of information about tumor formation and migration. : Darmanis et al. perform single-cell transcriptomic analyses of neoplastic and stromal cells within and proximal to primary glioblastomas. The authors describe a population of neoplastic-infiltrating glioblastoma cells as well as a putative role of tumor-infiltrating immune cells in supporting tumor growth. Keywords: single cell, RNA-seq, glioma, glioblastoma, GBM, brain, heterogeneity, infiltrating, diffuse, checkpoint

  11. Radioautographic study of the effects of colchicine in the cell cycle and in the migration of the ameloblasts in lower incisors of mice using 3H-thymidine

    International Nuclear Information System (INIS)

    Fernandez Samperiz, M.M.; Blumen, G.

    1984-01-01

    The effect of colchicine in the cell cycle and in the migration of the ameloblasts throughout the enamel organ in lower incisors of mice was studied radioautographycaly using 3 H-thymidine. The results showed a decrease of G(13.6h) and G 1 (3.7h) in the group of animals treated with colchicine. The decrease of G could be due to an increase of the number of ameloblasts in metaphase, as a consequence of the final action of the drug, which returns to the biocked cells the capacity of division. However, the decrease of G 1 could be due to the decrease of G, since the duration of this time was calculated indirectly. The delay in the velocity of migration of the ameloblasts could be caused by the interference of the drug in the mechanisms of eruption and/or growth of the tooth. (Author) [pt

  12. Atomic Resolution Structural and Chemical Imaging Revealing the Sequential Migration of Ni, Co, and Mn upon the Battery Cycling of Layered Cathode

    Energy Technology Data Exchange (ETDEWEB)

    Yan, Pengfei; Zheng, Jianming; Zhang, Ji-Guang; Wang, Chongmin

    2017-05-11

    Layered lithium transition metal oxides (LTMO) are promising candidate cathode materials for next generation high energy density lithium ion battery. The challenge for using this category of cathode is the capacity and voltage fading, which is believed to be associated with the layered structure disordering, a process that is initiated from the surface or solid-electrolyte interface and facilitated by transition metal (TM) reduction and oxygen vacancy formation. However, the atomic level dynamic mechanism of such a layered structure disordering is still not fully clear. In this work, utilizing atomic resolution electron energy loss spectroscopy (EELS), we map, for the first time at atomic scale, the spatial evolution of Ni, Co and Mn in a cycled LiNi1/3M1/3Co1/3O2 layered cathode. In combination with atomic level structural imaging, we discovered the direct correlation of TM ions migration behavior with lattice disordering, featuring the residing of TM ions in the tetrahedral site and a sequential migration of Ni, Co, and Mn upon the increased lattice disordering of the layered structure. This work highlights that Ni ions, though acting as the dominant redox species in many LTMO, are labile to migrate to cause lattice disordering upon battery cycling; while the Mn ions are more stable as compared with Ni and Co and can act as pillar to stabilize layered structure. Direct visualization of the behavior of TM ions during the battery cycling provides insight for designing of cathode with structural stability and correspondingly a superior performance.

  13. CMOS single-stage input-powered bridge rectifier with boost switch and duty cycle control

    Science.gov (United States)

    Radzuan, Roskhatijah; Mohd Salleh, Mohd Khairul; Hamzah, Mustafar Kamal; Ab Wahab, Norfishah

    2017-06-01

    This paper presents a single-stage input-powered bridge rectifier with boost switch for wireless-powered devices such as biomedical implants and wireless sensor nodes. Realised using CMOS process technology, it employs a duty cycle switch control to achieve high output voltage using boost technique, leading to a high output power conversion. It has only six external connections with the boost inductance. The input frequency of the bridge rectifier is set at 50 Hz, while the switching frequency is 100 kHz. The proposed circuit is fabricated on a single 0.18-micron CMOS die with a space area of 0.024 mm2. The simulated and measured results show good agreement.

  14. The link between migration, the reproductive cycle and condition of Sardinella aurita off Mauritania, north-west Africa

    NARCIS (Netherlands)

    Hofstede, ter R.; Dickey-Collas, M.; Mantingh, I.T.; Wague, A.

    2007-01-01

    The annual migration pattern of round sardinella Sardinella aurita up and down the north-western African coast between 12° N (Senegal) and 22° N (western Sahara) was shown to be associated with spawning activity and a distinct seasonality in fish condition, based on monthly sampling from commercial

  15. Integrating the augmented SCOR model and the ISO 15288 life cycle model into a single logistic model

    CSIR Research Space (South Africa)

    Schmitz, Peter MU

    2010-07-01

    Full Text Available using the Supply Chain Operations Reference (SCOR) model. The SANDF indicated that the augmented SCOR model (Bean, Schmitz and Engelbrecht, 2009) should be extended into a single logistics process which should include a life-cycle perspective...

  16. GESIT: a thermodynamic program for single cycle gas turbine plants with and without intercoolers

    Energy Technology Data Exchange (ETDEWEB)

    Heil, J

    1973-08-01

    A computer program for the thermodynamic modeling of singlecycle gas turbine plants is described. A high-temperature reactor is assumed as a heat source in the program, but the HTR can be replaced with another heat source without difficulty. Starting from a set of independent data, the program calculates efficiencies and mass flows. It indicates all values for a heat and power balance and prints out the temperatures and pressures for the different parts of the cycle. Besides this, the program is able to optimize the compression ratios for minimal power input. It also takes into account turbine rotor cooling (at the roots of the blades). Furthermore, the program is able to use either total pressure loss or specified losses in different parts of the cycle. The program GESlT can also handle systems with one or two intercoolers, or with no intercooler. GESIT gives all input and output values for the heat exchangers and turbo-machines. First the single-cycle gas turbine plant is described. After that the computational basis for the program and the program structure is explained. Instructions for data input are given so that the program can be immediately utilized. An example of input data together with the associated output is presented. (auth)

  17. Very High Cycle Fatigue of Ni-Based Single-Crystal Superalloys at High Temperature

    Science.gov (United States)

    Cervellon, A.; Cormier, J.; Mauget, F.; Hervier, Z.; Nadot, Y.

    2018-05-01

    Very high cycle fatigue (VHCF) properties at high temperature of Ni-based single-crystal (SX) superalloys and of a directionally solidified (DS) superalloy have been investigated at 20 kHz and a temperature of 1000 °C. Under fully reversed conditions (R = - 1), no noticeable difference in VHCF lifetimes between all investigated alloys has been observed. Internal casting pores size is the main VHCF lifetime-controlling factor whatever the chemical composition of the alloys. Other types of microstructural defects (eutectics, carbides), if present, may act as stress concentration sites when the number of cycles exceed 109 cycles or when porosity is absent by applying a prior hot isostatic pressing treatment. For longer tests (> 30 hours), oxidation also controls the main crack initiation sites leading to a mode I crack initiation from oxidized layer. Under such conditions, alloy's resistance to oxidation has a prominent role in controlling the VHCF. When creep damage is present at high ratios (R ≥ 0.8), creep resistance of SX/DS alloys governs VHCF lifetime. Under such high mean stress conditions, SX alloys developed to retard the initiation and creep propagation of mode I micro-cracks from pores have better VHCF lifetimes.

  18. Synchronous timing of multi-energy fast beam extraction during a single AGS cycle

    International Nuclear Information System (INIS)

    Gabusi, J.; Naase, S.

    1985-01-01

    Synchronous triggering of fast beams is required because the field of Kicker Magnets must rise within the open space between one beam bunch and the next. Within the Brookhaven AGS, Fast Extracted Beam (FEB) triggering combines nominal timing, based on beam energy with bunch-to-bunch synchronization, based on the accelerating rf waveform. During beam acceleration, a single bunch is extracted at 22 GeV/c and within the same AGS cycle, the remaining eleven bunches are extracted at 28.4 GeV/c. When the single bunch is extracted, a ''hole'', which is left in the remaining circulating beam, can appear in random locations within the second extraction during successive AGS cycles. To overcome this problem, a synchronous rf/12 counting scheme and logic circuitry are used to keep track of the bunch positions relative to each other, and to place the ''hole'' in any desired location within the second extraction. The rf/12 signal is used also to synchronize experimenters triggers

  19. Improving the Amazonian Hydrologic Cycle in a Coupled Land-Atmosphere, Single Column Model

    Science.gov (United States)

    Harper, A. B.; Denning, S.; Baker, I.; Prihodko, L.; Branson, M.

    2006-12-01

    We have coupled a land-surface model, the Simple Biosphere Model (SiB3), to a single column of the Colorado State University General Circulation Model (CSU-GCM) in the Amazon River Basin. This is a preliminary step in the broader goal of improved simulation of Basin-wide hydrology. A previous version of the coupled model (SiB2) showed drought and catastrophic dieback of the Amazon rain forest. SiB3 includes updated soil hydrology and root physiology. Our test area for the coupled single column model is near Santarem, Brazil, where measurements from the km 83 flux tower in the Tapajos National Forest can be used to evaluate model output. The model was run for 2001 using NCEP2 Reanalysis as driver data. Preliminary results show that the updated biosphere model coupled to the GCM produces improved simulations of the seasonal cycle of surface water balance and precipitation. Comparisons of the diurnal and seasonal cycles of surface fluxes are also being made.

  20. Parametric analyses of single-zone thorium-fueled molten salt reactor fuel cycle options

    International Nuclear Information System (INIS)

    Powers, J.J.; Worrall, A.; Gehin, J.C.; Harrison, T.J.; Sunny, E.E.

    2013-01-01

    Analyses of fuel cycle options based on thorium-fueled Molten Salt Reactors (MSRs) have been performed in support of fuel cycle screening and evaluation activities for the United States Department of Energy. The MSR options considered are based on thermal spectrum MSRs with 3 different separations levels: full recycling, limited recycling, and 'once-through' operation without active separations. A single-fluid, single-zone 2250 MWth (1000 MWe) MSR concept consisting of a fuel-bearing molten salt with graphite moderator and reflectors was used as the basis for this study. Radiation transport and isotopic depletion calculations were performed using SCALE 6.1 with ENDF/B-VII nuclear data. New methodology developed at Oak Ridge National Laboratory (ORNL) enables MSR analysis using SCALE, modeling material feed and removal by taking user-specified parameters and performing multiple SCALE/TRITON simulations to determine the resulting equilibrium operating conditions. Parametric analyses examined the sensitivity of the performance of a thorium MSR to variations in the separations efficiency for protactinium and fission products. Results indicate that self-sustained operation is possible with full or limited recycling but once-through operation would require an external neutron source. (authors)

  1. Moisture migration, microstructure damage and protein structure changes in porcine longissimus muscle as influenced by multiple freeze-thaw cycles.

    Science.gov (United States)

    Zhang, Mingcheng; Li, Fangfei; Diao, Xinping; Kong, Baohua; Xia, Xiufang

    2017-11-01

    This study investigated the effects of multiple freeze-thaw (F-T) cycles on water mobility, microstructure damage and protein structure changes in porcine longissimus muscle. The transverse relaxation time T 2 increased significantly when muscles were subjected to multiple F-T cycles (Pcycles caused sarcomere shortening, Z line fractures, and I band weakening and also led to microstructural destruction of muscle tissue. The decreased free amino group content and increased dityrosine in myofibrillar protein (MP) revealed that multiple F-T cycles caused protein cross-linking and oxidation. In addition, the results of size exclusion chromatography, circular dichroism spectra, UV absorption spectra, and intrinsic fluorescence spectroscopy indirectly proved that multiple F-T cycles could cause protein aggregation and degradation, α-helix structure disruption, hydrophobic domain exposure, and conformational changes of MP. Overall, repeated F-T cycles changed the protein structure and water distribution within meat. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Pan-Bcl-2 inhibitor obatoclax delays cell cycle progression and blocks migration of colorectal cancer cells.

    Directory of Open Access Journals (Sweden)

    Bruno Christian Koehler

    Full Text Available Despite the fact that new treatment regimes have improved overall survival of patients challenged by colorectal cancer (CRC, prognosis in the metastatic situation is still restricted. The Bcl-2 family of proteins has been identified as promising anti cancer drug target. Even though small molecules targeting Bcl-2 proteins are in clinical trials, little is known regarding their effects on CRC. The aim of this study was to preclinically investigate the value of ABT-737 and Obatoclax as anticancer drugs for CRC treatment. The effects of the BH3-mimetics ABT-737 and Obatoclax on CRC cells were assessed using viability and apoptosis assays. Wound healing migration and boyden chamber invasion assays were applied. 3-dimensional cell cultures were used for long term assessment of invasion and proliferation. Clinically relevant concentrations of pan-Bcl-2 inhibitor Obatoclax did not induce cell death. In contrast, the BH3-mimetic ABT-737 induced apoptosis in a dose dependent manner. Obatoclax caused a cell line specific slowdown of CRC cell growth. Furthermore, Obatoclax, but not ABT-737, recovered E-Cadherin expression and led to impaired migration and invasion of CRC cells. The proliferative capacity and invasiveness of CRC cells was strikingly inhibited by low dose Obatoclax in long term 3-dimensional cell cultures. Obatoclax, but not ABT-737, caused a G1-phase arrest accompanied by a downregulation of Cyclin D1 and upregulation of p27 and p21. Overexpression of Mcl-1, Bcl-xL or Bcl-2 reversed the inhibitory effect of Obatoclax on migration but failed to restore the proliferative capacity of Obatoclax-treated CRC cells. The data presented indicate broad and multifaceted antitumor effects of the pan-Bcl-2 inhibitor Obatoclax on CRC cells. In contrast to ABT-737, Obatoclax inhibited migration, invasion and proliferation in sublethal doses. In summary, this study recommends pan-Bcl-2 inhibition as a promising approach for clinical trials in CRC.

  3. Treatment outcome of women with a single ovary undergoing in vitro fertilisation cycles.

    Science.gov (United States)

    Hendricks, M S; Chin, H; Loh, S F

    2010-09-01

    Women with a single ovary present a unique problem in assisted reproductive techniques. The aim of our study was to compare the ovarian response and pregnancy rates of women with one ovary and those with two ovaries in assisted reproduction. A total of 18 consecutive women with a single ovary (n is 22 cycles) were identified. The control group included 44 women with two ovaries and mechanical infertility, who were selected as frequency-matched samples (2:1) to meet the distribution of age at treatment and race in the single ovary group. All patients underwent controlled ovarian hyperstimulation treatment via the long down-regulation protocol using a gonadotropin-releasing hormone agonist. Standard procedures were carried out for gamete-embryo handling, and embryo transfer was performed using a soft catheter on day two in all cases. The luteal phase was supported by progesterone or Pregnyl after oocyte pick-up. The duration of stimulation (11.3 +/- 1.7 versus 10.1 +/- 1.4 days) and the total follicle stimulating hormone (FSH) consumption (3906.8 +/- 1860.6 mIU/ml versus 2900.0 +/- 1440.0 mIU/ml) were significantly higher, and the mean number of oocytes (10.8 +/- 4.5 versus 16.8 +/- 10.9) and metaphase II oocytes collected (9.5 +/- 4.5 versus 13.3 +/- 7.7) were significantly lower in the single ovary group (p is less than 0.05). The clinical pregnancy rates (31.8 percent versus 43.2 percent) were comparable between the two groups. Although women with a single ovary required significantly higher doses of FSH and a longer duration of stimulation, as well as produced less oocytes, their clinical pregnancy rates were comparable to those of women with two ovaries in assisted reproduction.

  4. Oceanic migration behaviour of tropical Pacific eels from Vanuatu

    DEFF Research Database (Denmark)

    Schabetsberger, R; Økland, F; Aarestrup, K

    2013-01-01

    Information on oceanic migrations and spawning areas of tropical Pacific freshwater eels (genus Anguilla) is very limited. Lake Letas and its single outflowing river, Mbe Solomul on Gaua Island, Vanuatu, were surveyed for large migrating individuals. Twenty-four Anguilla marmorata (87 to 142 cm),...... impact of the lunar cycle on the upper limit of migration depths was found in A. marmorata (full moon: 230 m, new moon: 170 m). These behaviours may be explained as a trade-off between predator avoidance and the necessity to maintain a sufficiently high metabolism for migration....

  5. Migration chemistry

    International Nuclear Information System (INIS)

    Carlsen, L.

    1992-05-01

    Migration chemistry, the influence of chemical -, biochemical - and physico-chemical reactions on the migration behaviour of pollutants in the environment, is an interplay between the actual natur of the pollutant and the characteristics of the environment, such as pH, redox conditions and organic matter content. The wide selection of possible pollutants in combination with varying geological media, as well as the operation of different chemical -, biochemical - and physico-chemical reactions compleactes the prediction of the influence of these processes on the mobility of pollutants. The report summarizes a wide range of potential pollutants in the terrestrial environment as well as a variety of chemical -, biochemical - and physico-chemical reactions, which can be expected to influence the migration behaviour, comprising diffusion, dispersion, convection, sorption/desorption, precipitation/dissolution, transformations/degradations, biochemical reactions and complex formation. The latter comprises the complexation of metal ions as well as non-polar organics to naturally occurring organic macromolecules. The influence of the single types of processes on the migration process is elucidated based on theoretical studies. The influence of chemical -, biochemical - and physico-chemical reactions on the migration behaviour is unambiguous, as the processes apparently control the transport of pollutants in the terrestrial environment. As the simple, conventional K D concept breaks down, it is suggested that the migration process should be described in terms of the alternative concepts chemical dispersion, average-elution-time and effective retention. (AB) (134 refs.)

  6. Low Cycle Fatigue of Single Crystal Nickel-based Superalloy DD6 at 1100℃

    Directory of Open Access Journals (Sweden)

    ZHANG Shichao

    2018-02-01

    Full Text Available The total strain-controlled low cycle fatigue(LCF behaviors of a single crystal superalloy DD6 at 1100℃ for R=-1 and 0.05 were investigated. The results of LCF tests indicated that the cyclic hardening/softening behavior of the alloy not only has the relationship with the microstructure of the material, but also the loading status. The mean stress relaxation occurred under asymmetric straining. The rate of mean stress relaxation increased with the increasing of strain amplitude; when R=-1, the alloy shows tension-compression asymmetry behavior. All the LCF data obtain under various ratios were well correlated by three models for lifetime prediction, the precision rates predicted are fallen into the factor of±2 times scatter band.

  7. Excitation of random intense single-cycle light-pulse chains in optical fiber

    International Nuclear Information System (INIS)

    Ding, Y C; Zhang, F L; Gao, J B; Chen, Z Y; Lin, C Y; Yu, M Y

    2014-01-01

    Excitation of intense periodic single-cycle light pulses in a stochastic background arising from continuous wave stimulated Brillouin scattering (SBS) in a long optical fiber with weak optical feedback is found experimentally and modeled theoretically. Such intense light-pulse chains occur randomly and the optical feedback is a requirement for their excitation. The probability of these forms, among the large number of experimental output signals with identifiable waveforms, appearing is only about 3%, with the remainder exhibiting regular SBS characteristics. It is also found that pulses with low period numbers appear more frequently and the probability distribution for their occurrence in terms of the pulse power is roughly L-shaped, like that for rogue waves. The results from a three-wave-coupling model for SBS including feedback phase control agree well qualitatively with the observed phenomena. (paper)

  8. Single-Cycle Terahertz Pulse Generation from OH1 Crystal via Cherenkov Phase Matching

    Science.gov (United States)

    Uchida, Hirohisa; Oota, Kengo; Okimura, Koutarou; Kawase, Kodo; Takeya, Kei

    2018-06-01

    OH1 crystal is an organic nonlinear optical crystal with a large nonlinear optical constant. However, it has dispersion of refractive indices in the terahertz (THz) frequency. This limits the frequencies that satisfy the phase matching conditions for THz wave generation. In this study, we addressed the phase matching conditions for THz wave generation by combining an OH1 crystal with prism-coupled Cherenkov phase matching. We observed the generation of single-cycle THz pulses with a spectrum covering a frequency range of 3 THz. These results prove that combining prism-coupled Cherenkov phase matching with nonlinear optical crystals yields a THz wave generation method that is insusceptible to crystal dispersion.

  9. Influence of microstructure on low cycle fatigue in some single phase and biphasic stainless steels

    Energy Technology Data Exchange (ETDEWEB)

    Stolarz, J. [Ecole Nationale Superieure des Mines, Centre SMS, URA CNRS 1884, Saint-Etienne (France)

    2004-07-01

    This overview deals with the effects of microstructural parameters in different single phase and biphasic stainless steels on short crack behaviour and on fatigue life in the low cycle regime. The effect of the grain size is investigated in a single phase austenitic stainless steel. Under plastic strain control, the fatigue life increases when the grain size decreases. The results are discussed by analysing the distributions of crack depths as a function of the grain size. The second type of material is a metastable austenitic steel which partially transforms into martensite during LCF at temperatures between -50 C and +120 C. The grain size of the initially single phase austenitic microstructure has a combined influence on the volume fraction of martensite produced during fatigue and on the fatigue life. In this case, the grain size effect is still considerable but totally indirect because all fatigue cracks grow exclusively in the martensite. The cyclic behaviour analysis in biphasic alloys in which two phases undergo plastic deformation during LCF is considerably more complex because the conventional concept of microstructural barriers cannot be applied. The possible damage patterns in a pair of grains with different mechanical properties are discussed on the example of a solution treated and aged superduplex austenitic-ferritic stainless steel (SDSS). The hardening of one phase (ferrite) through ageing at 475 C changes the cyclic behaviour of the initial ''quasi single phase'' microstructure. Consequently, the fatigue life under plastic strain control decreases compared with the solution treated SDSS. The discussion is focussed on LCF damage mechanisms at the microstructure size scale with a particular accent put on the propagation of short cracks in the bulk. All the microstructures exhibit some common features with respect to the behaviour of short cracks. In particular a strong effect of microstructural barriers in the bulk and the

  10. Single embryo transfer: the role of natural cycle/minimal stimulation IVF in the future.

    Science.gov (United States)

    Nygren, Karl-Gösta

    2007-05-01

    There are several good reasons to assume that single embryo transfer (SET) eventually will become the norm internationally in IVF treatments. A tendency is clearly visible, as demonstrated in the latest IVF World Report. The Nordic countries and Belgium have been leading the way. Sweden at present has 70% SET, with 5% twins and a pregnancy rate per transfer remaining constant at about 30%. As a consequence, recent data show a drastic reduction of the risk of prematurity and therefore of child morbidity and perinatal mortality. It is now time to discuss alternatives to the current clinical policy of quite an aggressive ovarian stimulation in settings where SET is the norm. When and at what proportion could natural cycle/soft stimulation be used? What group of patients would benefit? What will the consequences be in terms of efficacy, safety, cost, time and quality of life? Selection of the most beneficial, rather than the most aggressive, ovarian stimulation protocol by clinicians and by the couples themselves in the future may well include a much wider use of natural cycle/soft stimulation in IVF.

  11. Duration of blastulation may be associated with ongoing pregnancy rate in single euploid blastocyst transfer cycles.

    Science.gov (United States)

    Mumusoglu, Sezcan; Ozbek, Irem Y; Sokmensuer, Lale K; Polat, Mehtap; Bozdag, Gurkan; Papanikolaou, Evangelos; Yarali, Hakan

    2017-12-01

    Not all euploid embryos implant, necessitating additional tools to select viable blastocysts in preimplantation genetic screening cycles. In this retrospective cohort study, 129 consecutive patients who underwent 129 single euploid blastocyst transfers in cryopreserved embryo transfer cycles were included. All embryos were individually cultured in a time-lapse incubator from intracytoplasmic sperm injection up to trophoectoderm biopsy. Twenty-three time-lapse morphokinetic variables were tested among patients with (n = 68) or without (n = 61) ongoing pregnancy. All 23 time-lapse morphokinetic variables, apart from duration of blastulation (tB-tSB), were comparable between patients with or without ongoing pregnancy. Duration of blastulation was significantly shorter in patients with ongoing pregnancy (8.1 ± 3.2 versus 9.5 ± 3.4 h; P = 0.014); shorter duration of blastulation remained an independent predictor for ongoing pregnancy, when tested by logistic regression analysis (OR 0.81; 95% CI 0.70 to 0.93). One important limitation of this study, and a reason for caution, is the use of multiple comparisons, which can lead to differences at the 0.05 level simply by chance or random variation. Nonetheless, the study suggests that when more than one euploid blastocyst is available, priority might be given to those with a shorter duration of blastulation. Copyright © 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

  12. The Caenorhabditis elegans Q neuroblasts : A powerful system to study cell migration at single-cell resolution in vivo

    NARCIS (Netherlands)

    Rella, Lorenzo; Fernandes Póvoa, Euclides E.; Korswagen, Hendrik C.

    2016-01-01

    During development, cell migration plays a central role in the formation of tissues and organs. Understanding the molecular mechanisms that drive and control these migrations is a key challenge in developmental biology that will provide important insights into disease processes, including cancer

  13. The Caenorhabditis elegans Q neuroblasts : A powerful system to study cell migration at single-cell resolution in vivo

    NARCIS (Netherlands)

    Rella, Lorenzo; Fernandes Póvoa, Euclides E; Korswagen, Hendrik C

    During development, cell migration plays a central role in the formation of tissues and organs. Understanding the molecular mechanisms that drive and control these migrations is a key challenge in developmental biology that will provide important insights into disease processes, including cancer

  14. Low-order models of a single-screw expander for organic Rankine cycle applications

    Science.gov (United States)

    Ziviani, D.; Desideri, A.; Lemort, V.; De Paepe, M.; van den Broek, M.

    2015-08-01

    Screw-type volumetric expanders have been demonstrated to be a suitable technology for organic Rankine cycle (ORC) systems because of higher overall effectiveness and good part-load behaviour over other positive displacement machines. An 11 kWe single-screw expander (SSE) adapted from an air compressor has been tested in an ORC test-rig operating with R245fa as working fluid. A total of 60 steady-steady points have been obtained at four different rotational speeds of the expander in the range between 2000 rpm and 3300 rpm. The maximum electrical power output and overall isentropic effectiveness measured were 7.3 kW and 51.9%, respectively. In this paper, a comparison between two low-order models is proposed in terms of accuracy of the predictions, the robustness of the model and the computational time. The first model is the Pacejka equation-based model and the second is a semi-empirical model derived from a well-known scroll expander model and modified to include the geometric aspects of a single screw expander. The models have been calibrated with the available steady-state measurement points by identifying the proper parameters.

  15. Development of a novel, single-cycle replicable rift valley Fever vaccine.

    Directory of Open Access Journals (Sweden)

    Shin Murakami

    2014-03-01

    Full Text Available Rift Valley fever virus (RVFV (genus Phlebovirus, family Bunyaviridae is an arbovirus that causes severe disease in humans and livestock in sub-Saharan African countries. Although the MP-12 strain of RVFV is a live attenuated vaccine candidate, neuroinvasiveness and neurovirulence of MP-12 in mice may be a concern when vaccinating certain individuals, especially those that are immunocompromised. We have developed a novel, single-cycle replicable MP-12 (scMP-12, which carries an L RNA, M RNA mutant encoding a mutant envelope protein lacking an endoplasmic reticulum retrieval signal and defective for membrane fusion function, and S RNA encoding N protein and green fluorescent protein. The scMP-12 underwent efficient amplification, then formed plaques and retained the introduced mutation after serial passages in a cell line stably expressing viral envelope proteins. However, inoculation of the scMP-12 into naïve cells resulted in a single round of viral replication, and production of low levels of noninfectious virus-like particles. Intracranial inoculation of scMP-12 into suckling mice did not cause clinical signs or death, a finding which demonstrated that the scMP-12 lacked neurovirulence. Mice immunized with a single dose of scMP-12 produced neutralizing antibodies, whose titers were higher than in mice immunized with replicon particles carrying L RNA and S RNA encoding N protein and green fluorescent protein. Moreover, 90% of the scMP-12-immunized mice were protected from wild-type RVFV challenge by efficiently suppressing viremia and replication of the challenge virus in the liver and the spleen. These data demonstrated that scMP-12 is a safe and immunogenic RVFV vaccine candidate.

  16. Supercharged two-cycle engines employing novel single element reciprocating shuttle inlet valve mechanisms and with a variable compression ratio

    Science.gov (United States)

    Wiesen, Bernard (Inventor)

    2008-01-01

    This invention relates to novel reciprocating shuttle inlet valves, effective with every type of two-cycle engine, from small high-speed single cylinder model engines, to large low-speed multiple cylinder engines, employing spark or compression ignition. Also permitting the elimination of out-of-phase piston arrangements to control scavenging and supercharging of opposed-piston engines. The reciprocating shuttle inlet valve (32) and its operating mechanism (34) is constructed as a single and simple uncomplicated member, in combination with the lost-motion abutments, (46) and (48), formed in a piston skirt, obviating the need for any complex mechanisms or auxiliary drives, unaffected by heat, friction, wear or inertial forces. The reciprocating shuttle inlet valve retains the simplicity and advantages of two-cycle engines, while permitting an increase in volumetric efficiency and performance, thereby increasing the range of usefulness of two-cycle engines into many areas that are now dominated by the four-cycle engine.

  17. Population specific migration patterns of an European-Afrotropical songbird

    DEFF Research Database (Denmark)

    Pedersen, Lykke; Tøttrup, Anders P.; Thorup, Kasper

    Every year, billions of songbirds migrate thousands of kilometres between the European and African continent. The fascinating behaviour of migration that we are witnessing today is assumed to have evolved through a series of dispersal events from Africa into Europe since the last glaciation period....... Recent technological advances are currently enabling us to track yet smaller songbirds throughout their migration cycle providing valuable insight into the life cycle of individual birds. However, direct tracking of migratory birds has so far mainly been conducted on single populations and our...... understanding of entire species migration systems is thus still limited. In this project we analyse the spatio-temporal migration schedule of Red-backed Shrikes, Lanius collurio, using tracking data from individuals originating from geographically distinct breeding populations (Scandinavia, the Netherlands...

  18. The Adoption of Advanced Fuel Cycle Technology Under a Single Repository Policy

    International Nuclear Information System (INIS)

    Wilson, Paul

    2009-01-01

    Develops the tools to investigate the hypothesis that the savings in repository space associated with the implementation of advanced nuclear fuel cycles can result in sufficient cost savings to offset the higher costs of those fuel cycles.

  19. Optimal design of solid oxide fuel cell, ammonia-water single effect absorption cycle and Rankine steam cycle hybrid system

    Science.gov (United States)

    Mehrpooya, Mehdi; Dehghani, Hossein; Ali Moosavian, S. M.

    2016-02-01

    A combined system containing solid oxide fuel cell-gas turbine power plant, Rankine steam cycle and ammonia-water absorption refrigeration system is introduced and analyzed. In this process, power, heat and cooling are produced. Energy and exergy analyses along with the economic factors are used to distinguish optimum operating point of the system. The developed electrochemical model of the fuel cell is validated with experimental results. Thermodynamic package and main parameters of the absorption refrigeration system are validated. The power output of the system is 500 kW. An optimization problem is defined in order to finding the optimal operating point. Decision variables are current density, temperature of the exhaust gases from the boiler, steam turbine pressure (high and medium), generator temperature and consumed cooling water. Results indicate that electrical efficiency of the combined system is 62.4% (LHV). Produced refrigeration (at -10 °C) and heat recovery are 101 kW and 22.1 kW respectively. Investment cost for the combined system (without absorption cycle) is about 2917 kW-1.

  20. Life cycle cost analysis of single slope hybrid (PV/T) active solar still

    International Nuclear Information System (INIS)

    Kumar, Shiv; Tiwari, G.N.

    2009-01-01

    This paper presents the life cycle cost analysis of the single slope passive and hybrid photovoltaic (PV/T) active solar stills, based on the annual performance at 0.05 m water depth. Effects of various parameters, namely interest rate, life of the system and the maintenance cost have been taken into account. The comparative cost of distilled water produced from passive solar still (Rs. 0.70/kg) is found to be less than hybrid (PV/T) active solar still (Rs. 1.93/kg) for 30 years life time of the systems. The payback periods of the passive and hybrid (PV/T) active solar still are estimated to be in the range of 1.1-6.2 years and 3.3-23.9 years, respectively, based on selling price of distilled water in the range of Rs. 10/kg to Rs. 2/kg. The energy payback time (EPBT) has been estimated as 2.9 and 4.7 years, respectively. (author)

  1. Dynamic expression of the translational machinery during Bacillus subtilis life cycle at a single cell level.

    Directory of Open Access Journals (Sweden)

    Alex Rosenberg

    Full Text Available The ability of bacteria to responsively regulate the expression of translation components is crucial for rapid adaptation to fluctuating environments. Utilizing Bacillus subtilis (B. subtilis as a model organism, we followed the dynamics of the translational machinery at a single cell resolution during growth and differentiation. By comprehensive monitoring the activity of the major rrn promoters and ribosomal protein production, we revealed diverse dynamics between cells grown in rich and poor medium, with the most prominent dissimilarities exhibited during deep stationary phase. Further, the variability pattern of translational activity varied among the cells, being affected by nutrient availability. We have monitored for the first time translational dynamics during the developmental process of sporulation within the two distinct cellular compartments of forespore and mother-cell. Our study uncovers a transient forespore specific increase in expression of translational components. Finally, the contribution of each rrn promoter throughout the bacterium life cycle was found to be relatively constant, implying that differential expression is not the main purpose for the existence of multiple rrn genes. Instead, we propose that coordination of the rrn operons serves as a strategy to rapidly fine tune translational activities in a synchronized fashion to achieve an optimal translation level for a given condition.

  2. Optimization of a single stage inverter with one cycle control for photovoltaic power generation

    Energy Technology Data Exchange (ETDEWEB)

    Egiziano, L.; Femia, N.; Granozio, D.; Petrone, G.; Spagnuolo, G. [Salermo Univ., Salermo (Italy); Vitelli, M. [Seconda Univ. di Napoli, Napoli (Italy)

    2006-07-01

    An optimized one-cycle control (OCC) for maximum power point tracking and power factor correction in grid-connected photovoltaic (PV) applications was described. OCC is a nonlinear control technique that rejects line perturbations and allows both output power factor co-reaction and tracking of input PV fields. An OCC system was analyzed in order to select optimal design parameters. Parameters were refined through the selection of suitable design constraints. A stochastic search was then performed. Criteria were then developed to distinguish appropriate design parameters for the optimized OCC. The optimization was based on advanced heuristic techniques for non-linear constrained optimization. Performance indices were calculated for each feasible set of parameters. A customized perturb and observe control was then applied to the single-stage inverter. Results of the optimization process were validated by a series of time-domain simulations conducted under heavy, varying irradiance conditions. Results of the simulations showed that the optimized controllers showed improved performance in terms of power drawn from the PV field. 7 refs., 1 tab., 5 figs.

  3. Replacing single frozen-thawed euploid embryos in a natural cycle in ovulatory women may increase live birth rates compared to medicated cycles in anovulatory women.

    Science.gov (United States)

    Melnick, Alexis P; Setton, Robert; Stone, Logan D; Pereira, Nigel; Xu, Kangpu; Rosenwaks, Zev; Spandorfer, Steven D

    2017-10-01

    The goal of this study was to compare pregnancy outcomes between natural frozen embryo transfer (FET) cycles in ovulatory women and programmed FET cycles in anovulatory women after undergoing in vitro fertilization with preimplantation genetic screening (IVF-PGS). This was a retrospective cohort study performed at an academic medical center. Patients undergoing single FET IVF-PGS cycles between October 2011 and December 2014 were included. Patients were stratified by type of endometrial replacement: programmed cycles with estrogen/progesterone replacement and natural cycles. IVF-PGS with 24-chromosome screening was performed on all included patients. Those patients with euploid embryos had single embryo transfer in a subsequent FET. The primary study outcome was live birth/ongoing pregnancy rate. Secondary outcomes included implantation, biochemical pregnancy, and miscarriage rates. One hundred thirteen cycles met inclusion criteria: 65 natural cycles and 48 programmed cycles. The programmed FET group was younger (35.9 ± 4.5 vs. 37.5 ± 3.7, P = 0.03) and had a higher AMH (3.95 ± 4.2 vs. 2.37 ± 2.4, P = 0.045). The groups were similar for BMI, gravidity, parity, history of uterine surgery, and incidence of Asherman's syndrome. There was also no difference in embryo grade at biopsy or transfer, and proportion of day 5 and day 6 transfers. Implantation rates were higher in the natural FET group (0.66 ± 0.48 vs. 0.44 ± 0.50, P = 0.02). There was no difference in the rates of biochemical pregnancy or miscarriage. After controlling for age, live birth/ongoing pregnancy rate was higher in natural FETs with an adjusted odds ratio of 2.68 (95% CI 1.22-5.87). Natural FET in ovulatory women after IVF-PGS is associated with increased implantation and live birth rates compared to programmed FET in anovulatory women. Further investigation is needed to determine whether these findings hold true in other patient cohorts.

  4. Self-phase modulation of a single-cycle terahertz pulse by nonlinear free-carrier response in a semiconductor

    DEFF Research Database (Denmark)

    Turchinovich, Dmitry; Hvam, Jørn Märcher; Hoffmann, Matthias C.

    2012-01-01

    We investigate the self-phase modulation (SPM) of a single-cycle terahertz pulse in a semiconductor, using bulk n-GaAs as a model system. The SPM arises from the heating of free electrons in the electric field of the terahertz pulse, leading to an ultrafast reduction of the plasma frequency...

  5. Critical firing and misfiring boundary in a spark ignition methanol engine during cold start based on single cycle fuel injection

    International Nuclear Information System (INIS)

    Li, Zhaohui; Gong, Changming; Qu, Xiang; Liu, Fenghua; Sun, Jingzhen; Wang, Kang; Li, Yufeng

    2015-01-01

    The influence of the mass of methanol injected per cycle, ambient temperature, injection and ignition timing, preheating methods, and supplying additional liquefied petroleum gas (LPG) injection into the intake manifold on the critical firing and misfiring boundary of an electronically injection controlled spark ignition (SI) methanol engine during cold start were investigated experimentally based on a single cycle fuel injection with cycle-by-cycle control strategy. The critical firing and misfiring boundary was restricted by all parameters. For ambient temperatures below 16 °C, methanol engines must use auxiliary start-aids during cold start. Optimal control of the methanol injection and ignition timing can realize ideal next cycle firing combustion after injection. Resistance wire and glow plug preheating can provide critical firing down to ambient temperatures of 5 °C and 0 °C, respectively. Using an additional LPG injection into the intake manifold can provide critical firing down to an ambient temperature of −13 °C during cold start. As the ambient temperature decreases, the optimal angle difference between methanol injection timing and LPG injection timing for critical firing of a methanol engine increases rapidly during cold start. - Highlights: • A single cycle fuel injection and cycle-by-cycle control strategy are used to study. • In-cylinder pressure and instantaneous speed were used to determine firing boundary. • For the ambient temperatures below 16 °C, an auxiliary start-aids must be used. • A preheating and additional LPG were used to expand critical firing boundary. • Additional LPG can result in critical firing down to ambient temperature of −13 °C

  6. Hamster activity and estrous cycles: control by a single versus multiple circadian oscillator(s).

    OpenAIRE

    Carmichael, M S; Nelson, R J; Zucker, I

    1981-01-01

    Running activity onset and estrous onset were recorded for hamsters exposed to progressively shorter daily light/dark (T) cycles. The period of the estrous cycle was a quadruple multiple of the period of the activity rhythm during entrainment to T cycles of 23.5-21.5 hr. There was no evidence of desynchronization of the activity and estrus rhythms. The very short estrous periods shown during exposure to short T cycles indicate that an intrinsic 96-hr interval for ovarian follicular maturation...

  7. Chemical Engineering Division Fuel Cycle Programs. Quarterly progress report, April-June 1978. [Advanced solvent extraction; accidents; pyrochemical; radwaste in metal matrix; waste migration

    Energy Technology Data Exchange (ETDEWEB)

    Steindler, M. J.; Ader, M.; Barletta, R. E.

    1979-12-01

    Fuel cycle studies reported include development of centrifugal contactors for Purex processes. Tricaprylmethyl-ammonium nitrate and di-n-amyl-n-amylphosphonate are being evaluated as Thorex extractants. Dispersion of uranium and plutonium by fires, and mechanisms for subdividing and dispersing liquids and solids were reviewed. In the pyrochemical and dry processing program, a facility for testing containment materials is under construction; a flowsheet for carbide fuel processing has been designed and studies of carbide reactions in bismuth are underway; salt transport processes are being studied; process-size refractory metal vessels are being fabricated; the feasibility of AIROX reprocessing is being determined; the solubility of UO/sub 2/, UO/sub 2/ + fission products, and PuO/sub 2/ in molten alkali metal nitrates, has been investigated; a flowsheet was developed for reprocessing actinide oxides in molten salts; preparation of Th-U carbide from the oxide is being studied; new flowsheets based on the Dow Aluminum Pyrometallurgical process for reprocessing of spent uranium metal fuel have been prepared; the chloride volitility processing of thorium-based fuels is being studied; the reprocessing of (Th,U)O/sub 2/ solid solution in KCl-LiCl-ThCl/sub 4/-Th is being studied; and a flowsheet for processing spent nuclear fuel in molten tin has been constructed. Leach rates of simulated encapsulated waste forms in a metal matrix were studied. Nine criteria for handling waste cladding hulls were established. Strontium and tin migration in glauconite columns was measured. Radioactive Sr in a stream of water moved through oolitic limestone as rapidly as water, but in a stream of water equilibrated with the limestone, Sr moved through the limestone one-tenth as fast. Migration of trace quantities of Cs and I through kaolinite was studied. 88 figures, 53 tables.

  8. Inhibition of cell proliferation and migration by oxidative stress from ascorbate-driven juglone redox cycling in human bladder-derived T24 cells

    Energy Technology Data Exchange (ETDEWEB)

    Kviecinski, M.R., E-mail: mrkviecinski@hotmail.com [Laboratorio de Bioquimica Experimental, Departamento de Bioquimica, Universidade Federal de Santa Catarina, Florianopolis (Brazil); Pedrosa, R.C., E-mail: rozangelapedrosa@gmail.com [Laboratorio de Bioquimica Experimental, Departamento de Bioquimica, Universidade Federal de Santa Catarina, Florianopolis (Brazil); Felipe, K.B., E-mail: kakabettega@yahoo.com.br [Laboratorio de Bioquimica Experimental, Departamento de Bioquimica, Universidade Federal de Santa Catarina, Florianopolis (Brazil); Farias, M.S., E-mail: mirellesfarias@hotmail.com [Laboratorio de Bioquimica Experimental, Departamento de Bioquimica, Universidade Federal de Santa Catarina, Florianopolis (Brazil); Glorieux, C., E-mail: christophe.glorieux@uclouvain.be [Toxicology and Cancer Biology Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, 73 Avenue E. Mounier, GTOX 7309, 1200 Brussels (Belgium); Valenzuela, M., E-mail: mavalenzuela@med.uchile.cl [Toxicology and Cancer Biology Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, 73 Avenue E. Mounier, GTOX 7309, 1200 Brussels (Belgium); Sid, B., E-mail: brice.sid@uclouvain.be [Toxicology and Cancer Biology Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, 73 Avenue E. Mounier, GTOX 7309, 1200 Brussels (Belgium); and others

    2012-05-04

    Highlights: Black-Right-Pointing-Pointer The cytotoxicity of juglone is markedly increased by ascorbate. Black-Right-Pointing-Pointer T24 cell death by oxidative stress is necrosis-like. Black-Right-Pointing-Pointer Redox cycling by juglone/ascorbate inhibits cell proliferation. Black-Right-Pointing-Pointer Cellular migration is impaired by juglone/ascorbate. -- Abstract: The effects of juglone on T24 cells were assessed in the presence and absence of ascorbate. The EC{sub 50} value for juglone at 24 h decreased from 28.5 {mu}M to 6.3 {mu}M in the presence of ascorbate. In juglone-treated cells, ascorbate increased ROS formation (4-fold) and depleted GSH (65%). N-acetylcysteine or catalase restricted the juglone/ascorbate-mediated effects, highlighting the role of oxidative stress in juglone cytotoxicity. Juglone alone or associated with ascorbate did not cause caspase-3 activation or PARP cleavage, suggesting necrosis-like cell death. DNA damage and the mild ER stress caused by juglone were both enhanced by ascorbate. In cells treated with juglone (1-5 {mu}M), a concentration-dependent decrease in cell proliferation was observed. Ascorbate did not impair cell proliferation but its association with juglone led to a clonogenic death state. The motility of ascorbate-treated cells was not affected. Juglone slightly restricted motility, but cells lost their ability to migrate most noticeably when treated with juglone plus ascorbate. We postulate that juglone kills cells by a necrosis-like mechanism inhibiting cell proliferation and the motility of T24 cells. These effects are enhanced in the presence of ascorbate.

  9. High gonadotropin dosage does not affect euploidy and pregnancy rates in IVF PGS cycles with single embryo transfer.

    Science.gov (United States)

    Barash, Oleksii O; Hinckley, Mary D; Rosenbluth, Evan M; Ivani, Kristen A; Weckstein, Louis N

    2017-11-01

    Does high gonadotropin dosage affect euploidy and pregnancy rates in PGS cycles with single embryo transfer? High gonadotropin dosage does NOT affect euploidy and pregnancy rates in PGS cycles with single embryo transfer. PGS has been proven to be the most effective and reliable method for embryo selection in IVF cycles. Euploidy and blastulation rates decrease significantly with advancing maternal age. In order to recruit an adequate number of follicles, the average dosage of gonadotropins administered during controlled ovarian stimulation in IVF cycles often increases significantly with advancing maternal age. A retrospective study of SNP (Single Nucleotide Polymorphism) PGS outcome data from blastocysts biopsied on day 5 or day 6 was conducted to identify differences in euploidy and clinical pregnancy rates. Seven hundred and ninety four cycles of IVF treatment with PGS between January 2013 and January 2017 followed by 651 frozen embryo transfers were included in the study (506 patients, maternal age (y.o.) - 37.2 ± 4.31). A total of 4034 embryos were analyzed (5.1 ± 3.76 per case) for euploidy status. All embryos were vitrified after biopsy, and selected embryos were subsequently thawed for a hormone replacement frozen embryo transfer cycle. All cycles were analyzed by total gonadotropin dosage (5000 IU), by number of eggs retrieved (1-5, 5-10, 10-15 and >15 eggs) and patient's age (cycles) euploidy rates ranged from 62.3% (cycle) to 67.5% (>5000 IU were used in the IVF cycle) (OR = 0.862, 95% CI 0.687-1.082, P = 0.2) and from 69.5% (1-5 eggs retrieved) to 60.0% (>15 eggs retrieved) (OR = 0.658, 95% CI 0.405-1.071, P = 0.09). Similar data were obtained in the oldest group of patients (≥41 y.o. - 189 IVF cycles): euploidy rates ranged from 30.7 to 26.4% (OR = 0.811, 95% CI 0.452-1.454, P = 0.481) when analyzed by total dosage of gonadotropins used in the IVF cycle and from 40.0 to 30.7% (OR = 0.531, 95% CI 0.204-1.384, P = 0.19), when assessed by the total

  10. Numerical investigation on lateral migration and lift force of single bubble in simple shear flow in low viscosity fluid using volume of fluid method

    International Nuclear Information System (INIS)

    Zhongchun, Li; Xiaoming, Song; Shengyao, Jiang; Jiyang, Yu

    2014-01-01

    Highlights: • A VOF simulation of bubble in low viscosity fluid was conducted. • Lift force in different viscosity fluid had different lateral migration characteristics. • Bubble with different size migrated to different direction. • Shear stress triggered the bubble deformation process and the bubble deformation came along with the oscillation behaviors. - Abstract: Two phase flow systems have been widely used in industrial engineering. Phase distribution characteristics are vital to the safety operation and optimization design of two phase flow systems. Lift force has been known as perpendicular to the bubbles’ moving direction, which is one of the mechanisms of interfacial momentum transfer. While most widely used lift force correlations, such as the correlation of Tomiyama et al. (2002), were obtained by experimentally tracking single bubble trajectories in high viscosity glycerol–water mixture, the applicability of these models into low viscosity fluid, such as water in nuclear engineering system, needs to be further evaluated. In the present paper, bubble in low viscosity fluid in shear flow was investigated in a full 3D numerical simulation and the volume of fluid (VOF) method was applied to capture the interface. The fluid parameter: fluid viscosity, bubble parameter: diameter and external flow parameters: shear stress magnitude and liquid velocity were examined. Comparing with bubble in high viscosity shear flow and bubble in low viscosity still flow, relative large bubble in low viscosity shear flow keep an oscillation way towards the moving wall and experienced a shape deformation process. The oscillation amplitude increased as the viscosity of fluid decreased. Small bubble migrated to the static wall in a line with larger migration velocity than that in high viscosity fluid and no deformation occurred. The shear stress triggered the oscillation behaviors while it had no direct influence with the behavior. The liquid velocity had no effect on

  11. Administration of single-dose GnRH agonist in the luteal phase in ICSI cycles: a meta-analysis

    Directory of Open Access Journals (Sweden)

    Oliveira João

    2010-09-01

    Full Text Available Abstract Background The effects of gonadotrophin-releasing hormone agonist (GnRH-a administered in the luteal phase remains controversial. This meta-analysis aimed to evaluate the effect of the administration of a single-dose of GnRH-a in the luteal phase on ICSI clinical outcomes. Methods The research strategy included the online search of databases. Only randomized studies were included. The outcomes analyzed were implantation rate, clinical pregnancy rate (CPR per transfer and ongoing pregnancy rate. The fixed effects model was used for odds ratio. In all trials, a single dose of GnRH-a was administered at day 5/6 after ICSI procedures. Results All cycles presented statistically significantly higher rates of implantation (P Conclusions These findings demonstrate that the luteal-phase single-dose GnRH-a administration can increase implantation rate in all cycles and CPR per transfer and ongoing pregnancy rate in cycles with GnRH antagonist ovarian stimulation protocol. Nevertheless, by considering the heterogeneity between the trials, it seems premature to recommend the use of GnRH-a in the luteal phase. Additional randomized controlled trials are necessary before evidence-based recommendations can be provided.

  12. A new six stroke single cylinder diesel engine referring Rankine cycle

    International Nuclear Information System (INIS)

    Chen, Hao; Guo, Qi; Yang, Lu; Liu, Shenghua; Xie, Xuliang; Chen, Zhaoyang; Liu, Zengqiang

    2015-01-01

    Six stroke engine presented by Conklin and Szybist is an effective way to recover energy of exhaust gas by adding a partial exhaust stroke and steam expansion stroke. Characteristics of the engine are analyzed and its disadvantages are pointed out. A new six stroke diesel engine is presented here. It refers rankine cycle inside cylinder. Total exhaust gas is recompressed and at a relatively low back pressure in the fourth stroke water is injected to which maintains liquid phase until the piston moves to the TDC. At c′ 720 °CA (crank angle) the water becomes saturated. An ideal thermodynamics model of exhaust gas compression, water injection and expansion is constructed to investigate this modification. Properties at characteristic points are calculated to determine the increased indicated work. Results show that the work increases with the advance of water injection timing and the quality of water. The cycle is more efficient and the new engine has potential for saving energy. Moreover, it is forecasted that HC and PM emissions may reform with steam in reality and H 2 is produced which will react with NO X . - Highlights: • A new six stroke diesel engine is introduced and a new ideal cycle is constructed. • Increased indicated work of the cycle proves that the cycle is more efficient. • In reality steam may reform with HC and PM and produced H 2 may react with NO X emission. • The engine has the potential for energy saving and emission reducing

  13. The effect of a single infusion of zoledronic acid on early implant migration in total hip arthroplasty. A randomized, double-blind, controlled trial.

    Science.gov (United States)

    Friedl, Gerald; Radl, Roman; Stihsen, Christoph; Rehak, Peter; Aigner, Reingard; Windhager, Reinhard

    2009-02-01

    Aseptic loosening is the most frequent cause of implant failure in total hip arthroplasty. While a direct link between aseptic loosening and periprosthetic bone loss remains elusive, there is plentiful evidence for a close association with early implant migration. The present trial was primarily designed to evaluate whether a single infusion of 4 mg of zoledronic acid prevented early implant migration in patients with osteonecrosis of the femoral head. Fifty patients were consecutively enrolled to receive either zoledronic acid or saline solution after cementless total hip arthroplasty. Radiographs, biochemical parameters of bone turnover, and the Harris hip-rating score were determined preoperatively and at each follow-up examination at seven weeks, six months, one year, and yearly thereafter. The median follow-up period was 2.8 years. We found a significant subsidence of the stem of up to a mean (and standard deviation) of -1.2 +/- 0.6 mm at two years within the control group, and the cups had a mean medialization of 0.6 +/- 1.0 mm and a mean cranialization of 0.6 +/- 0.8 mm (p < 0.001). Treatment with zoledronic acid effectively minimized the migration of the cups in both the transverse and the vertical direction (mean, 0.15 +/- 0.6 mm and 0.06 +/- 0.6 mm, respectively; p < 0.05), while only a trend to decreased subsidence of the stem was detected. Finally, the Harris hip score rapidly increased over time in both treatment groups, although this increase was significantly more pronounced in the zoledronate-treated group than in the control group (analysis of variance, p = 0.008). A single infusion of zoledronic acid shows promise in improving initial fixation of a cementless implant, which may improve the clinical outcome of total hip arthroplasty in patients with osteonecrosis of the femoral head.

  14. Experimental Comparison Of Working Fluids For Organic Rankine Cycle With Single-Screw Expander

    OpenAIRE

    Gusev, Sergei; Ziviani, Davide; Bell, Ian; De Paepe, Michel; van den Broek, Martijn

    2014-01-01

    This paper describes the behavior of an Organic Rankine Cycle (ORC) fed by a heat source with adaptable temperature and mass flow. For a suitable choice of working fluid, the setting of its evaporation pressure is crucial for the performance of an ORC installation. The higher the evaporation pressure, the higher the cycle efficiency on the one hand, but the lower the energy recovered from the heat source due to a higher outlet temperature on the other hand. An optimum has to be found to achie...

  15. Transient impairments in single muscle fibre contractile function after prolonged cycling in elite endurance athletes

    DEFF Research Database (Denmark)

    Hvid, L G; Gejl, Kasper Degn; Bech, R D

    2013-01-01

    Prolonged muscle activity impairs whole-muscle performance and function. However, little is known about the effects of prolonged muscle activity on the contractile function of human single muscle fibres. The purpose of this study was to investigate the effects of prolonged exercise and subsequent...... recovery on the contractile function of single muscle fibres obtained from elite athletes....

  16. Single and combined effects of beetroot juice and caffeine supplementation on cycling time trial performance.

    Science.gov (United States)

    Lane, Stephen C; Hawley, John A; Desbrow, Ben; Jones, Andrew M; Blackwell, James R; Ross, Megan L; Zemski, Adam J; Burke, Louise M

    2014-09-01

    Both caffeine and beetroot juice have ergogenic effects on endurance cycling performance. We investigated whether there is an additive effect of these supplements on the performance of a cycling time trial (TT) simulating the 2012 London Olympic Games course. Twelve male and 12 female competitive cyclists each completed 4 experimental trials in a double-blind Latin square design. Trials were undertaken with a caffeinated gum (CAFF) (3 mg·kg(-1) body mass (BM), 40 min prior to the TT), concentrated beetroot juice supplementation (BJ) (8.4 mmol of nitrate (NO3(-)), 2 h prior to the TT), caffeine plus beetroot juice (CAFF+BJ), or a control (CONT). Subjects completed the TT (females: 29.35 km; males: 43.83 km) on a laboratory cycle ergometer under conditions of best practice nutrition: following a carbohydrate-rich pre-event meal, with the ingestion of a carbohydrate-electrolyte drink and regular oral carbohydrate contact during the TT. Compared with CONT, power output was significantly enhanced after CAFF+BJ and CAFF (3.0% and 3.9%, respectively, p caffeine (-0.9%, p = 0.4 compared with CAFF). We conclude that caffeine (3 mg·kg(-1) BM) administered in the form of a caffeinated gum increased cycling TT performance lasting ∼50-60 min by ∼3%-4% in both males and females. Beetroot juice supplementation was not ergogenic under the conditions of this study.

  17. Optimum Envelope of a Single-Family House Based on Life Cycle Analysis

    Directory of Open Access Journals (Sweden)

    Marie-Claude Hamelin

    2014-04-01

    Full Text Available This paper describes the methodology used for the life cycle cost (LCC and life cycle energy (LCE analyses of the case study house in Quebec, Canada. The TRNSYS energy analysis program is coupled with GenOpt, a general purpose optimization program, for the purpose of this study. The particle swarm optimization (PSO algorithm is used for the search for the optimum solution. Results show that the optimum levels of insulation should be higher than the reference values, even for the case of LCC analysis. The results are for the most part still valid if electricity costs are assumed to increase below the inflation rate for the duration of the study period.

  18. Using single cell cultivation system for on-chip monitoring of the interdivision timer in Chlamydomonas reinhardtii cell cycle

    Directory of Open Access Journals (Sweden)

    Soloviev Mikhail

    2010-09-01

    Full Text Available Abstract Regulation of cell cycle progression in changing environments is vital for cell survival and maintenance, and different regulation mechanisms based on cell size and cell cycle time have been proposed. To determine the mechanism of cell cycle regulation in the unicellular green algae Chlamydomonas reinhardtii, we developed an on-chip single-cell cultivation system that allows for the strict control of the extracellular environment. We divided the Chlamydomonas cell cycle into interdivision and division phases on the basis of changes in cell size and found that, regardless of the amount of photosynthetically active radiation (PAR and the extent of illumination, the length of the interdivision phase was inversely proportional to the rate of increase of cell volume. Their product remains constant indicating the existence of an 'interdivision timer'. The length of the division phase, in contrast, remained nearly constant. Cells cultivated under light-dark-light conditions did not divide unless they had grown to twice their initial volume during the first light period. This indicates the existence of a 'commitment sizer'. The ratio of the cell volume at the beginning of the division phase to the initial cell volume determined the number of daughter cells, indicating the existence of a 'mitotic sizer'.

  19. Single-cell analysis of transcription kinetics across the cell cycle

    Science.gov (United States)

    Skinner, Samuel O; Xu, Heng; Nagarkar-Jaiswal, Sonal; Freire, Pablo R; Zwaka, Thomas P; Golding, Ido

    2016-01-01

    Transcription is a highly stochastic process. To infer transcription kinetics for a gene-of-interest, researchers commonly compare the distribution of mRNA copy-number to the prediction of a theoretical model. However, the reliability of this procedure is limited because the measured mRNA numbers represent integration over the mRNA lifetime, contribution from multiple gene copies, and mixing of cells from different cell-cycle phases. We address these limitations by simultaneously quantifying nascent and mature mRNA in individual cells, and incorporating cell-cycle effects in the analysis of mRNA statistics. We demonstrate our approach on Oct4 and Nanog in mouse embryonic stem cells. Both genes follow similar two-state kinetics. However, Nanog exhibits slower ON/OFF switching, resulting in increased cell-to-cell variability in mRNA levels. Early in the cell cycle, the two copies of each gene exhibit independent activity. After gene replication, the probability of each gene copy to be active diminishes, resulting in dosage compensation. DOI: http://dx.doi.org/10.7554/eLife.12175.001 PMID:26824388

  20. Analysis and mitigation of systematic errors in spectral shearing interferometry of pulses approaching the single-cycle limit [Invited

    International Nuclear Information System (INIS)

    Birge, Jonathan R.; Kaertner, Franz X.

    2008-01-01

    We derive an analytical approximation for the measured pulse width error in spectral shearing methods, such as spectral phase interferometry for direct electric-field reconstruction (SPIDER), caused by an anomalous delay between the two sheared pulse components. This analysis suggests that, as pulses approach the single-cycle limit, the resulting requirements on the calibration and stability of this delay become significant, requiring precision orders of magnitude higher than the scale of a wavelength. This is demonstrated by numerical simulations of SPIDER pulse reconstruction using actual data from a sub-two-cycle laser. We briefly propose methods to minimize the effects of this sensitivity in SPIDER and review variants of spectral shearing that attempt to avoid this difficulty

  1. From single steps to mass migration: the problem of scale in the movement ecology of the Serengeti wildebeest.

    Science.gov (United States)

    Torney, Colin J; Hopcraft, J Grant C; Morrison, Thomas A; Couzin, Iain D; Levin, Simon A

    2018-05-19

    A central question in ecology is how to link processes that occur over different scales. The daily interactions of individual organisms ultimately determine community dynamics, population fluctuations and the functioning of entire ecosystems. Observations of these multiscale ecological processes are constrained by various technological, biological or logistical issues, and there are often vast discrepancies between the scale at which observation is possible and the scale of the question of interest. Animal movement is characterized by processes that act over multiple spatial and temporal scales. Second-by-second decisions accumulate to produce annual movement patterns. Individuals influence, and are influenced by, collective movement decisions, which then govern the spatial distribution of populations and the connectivity of meta-populations. While the field of movement ecology is experiencing unprecedented growth in the availability of movement data, there remain challenges in integrating observations with questions of ecological interest. In this article, we present the major challenges of addressing these issues within the context of the Serengeti wildebeest migration, a keystone ecological phenomena that crosses multiple scales of space, time and biological complexity.This article is part of the theme issue 'Collective movement ecology'. © 2018 The Author(s).

  2. Experimental Investigation of a Multi-Cycle Single-Tube Pulse Detonation Rocket Engine with a Coaxial Rotary Valve

    Science.gov (United States)

    Matsuoka, Ken; Esumi, Motoki; Ikeguchi, Ken Bryan; Kasahara, Jiro; Matsuo, Akiko; Funaki, Ikkoh

    We developed a novel coaxial rotary valve for a multi-tube PDE. Since this single valve can supply three different gases (fuel, oxidizer and purge gas) into a combustor, the unification of the valve systems for three different gases is possible by using our newly designed valve. A PDRE system can be simple and lightweight by using this valve, and thus its thrust-weight ratio can be increased. We proposed the design of a multi-tube rotary-valved PDRE system by this rotary valve. Moreover, in preparation for a multi-tube rotary-valved PDRE, we carried out the multi-cycle operation experiment by the single-tube rotary-valved PDRE system. The combustion wave velocity was measured to confirm the operation of the PDRE system. Deflagration-to-detonation transition (DDT) was confirmed and DDT distance decreased under the condition of high operation frequency. In addition, a maximum operation frequency was 159 Hz.

  3. Impact of jamming on collective cell migration

    Science.gov (United States)

    Nnetu, Kenechukwu David; Knorr, Melanie; Pawlizak, Steve; Fuhs, Thomas; Zink, Mareike; KäS, Josef A.

    2012-02-01

    Multi-cellular migration plays an important role in physiological processes such as embryogenesis, cancer metastasis and tissue repair. During migration, single cells undergo cycles of extension, adhesion and retraction resulting in morphological changes. In a confluent monolayer, there are inter-cellular interactions and crowding, however, the impact of these interactions on the dynamics and elasticity of the monolayer at the multi-cellular and single cell level is not well understood. Here we study the dynamics of a confluent epithelial monolayer by simultaneously measuring cell motion at the multi-cellular and single cell level for various cell densities and tensile elasticity. At the multi-cellular level, the system exhibited spatial kinetic transitions from isotropic to anisotropic migration on long times and the velocity of the monolayer decreased with increasing cell density. Moreover, the dynamics was spatially and temporally heterogeneous. Interestingly, the dynamics was also heterogeneous in wound-healing assays and the correlation length was fitted by compressed exponential. On the single cell scale, we observed transient caging effects with increasing cage rearrangement times as the system age due to an increase in density. Also, the density dependent elastic modulus of the monolayer scaled as a weak power law. Together, these findings suggest that caging effects at the single cell level initiates a slow and heterogeneous dynamics at the multi-cellular level which is similar to the glassy dynamics of deformable colloidal systems.

  4. Factors affecting {sup 223}Ra therapy: clinical experience after 532 cycles from a single institution

    Energy Technology Data Exchange (ETDEWEB)

    Etchebehere, Elba C. [The University of Texas MD Anderson Cancer Center, Department of Nuclear Medicine, Houston, TX (United States); Campinas State University (Unicamp), Department of Nuclear Medicine, Campinas (Brazil); Milton, Denai R. [The University of Texas MD Anderson Cancer Center, Department of Biostatistics, Houston, TX (United States); Araujo, John C. [The University of Texas MD Anderson Cancer Center, Department of Genitourinary Medical Oncology, Houston, TX (United States); Swanston, Nancy M.; Macapinlac, Homer A.; Rohren, Eric M. [The University of Texas MD Anderson Cancer Center, Department of Nuclear Medicine, Houston, TX (United States)

    2016-01-15

    The aim of this study was to identify baseline features that predict outcome in {sup 223}Ra therapy. We retrospectively reviewed 110 patients with metastatic castration-resistant prostate cancer treated with {sup 223}Ra. End points were overall survival (OS), progression-free survival (PFS), bone event-free survival (BeFS), and bone marrow failure (BMF). The following parameters were evaluated prior to the first {sup 223}Ra cycle: serum levels of hemoglobin (Hb), prostate-specific antigen (PSA), alkaline phosphatase (ALP), Eastern Cooperative Oncology Group (ECOG) status, pain score, use of chemotherapy, and external beam radiation therapy (EBRT). During/after {sup 223}Ra we evaluated: the total number of radium cycles (Ra{sub Tot}), the PSA doubling time (PSA{sub DT}), and the use of chemotherapy, EBRT, abiraterone, and enzalutamide. A significant reduction of ALP (p < 0.001) and pain score (p = 0.041) occurred throughout the {sup 223} Ra cycles. The risk of progression was associated with declining ECOG status [hazard ratio (HR) = 3.79; p < 0.001] and decrease in PSA{sub DT} (HR = 8.22; p < 0.001). Ra{sub Tot}, ALP, initial ECOG status, initial pain score, and use of abiraterone were associated with OS (p ≤ 0.008), PFS (p ≤ 0.003), and BeFS (p ≤ 0.020). Ra{sub Tot}, ALP, initial ECOG status, and initial pain score were significantly associated with BMF (p ≤ 0.001) as well as Hb (p < 0.001) and EBRT (p = 0.009). On multivariable analysis, only Ra{sub Tot} and abiraterone remained significantly associated with OS (p < 0.001; p = 0.033, respectively), PFS (p < 0.001; p = 0.041, respectively), and BeFS (p < 0.001; p = 0.019, respectively). Additionally, Ra{sub Tot} (p = 0.027) and EBRT (p = 0.013) remained significantly associated with BMF. Concomitant use of abiraterone and {sup 223}Ra seems to have a beneficial effect, while the EBRT may increase the risk of BMF. (orig.)

  5. Interaction of high cycle fatigue with high temperature creep in superalloy single crystals

    Czech Academy of Sciences Publication Activity Database

    Lukáš, Petr; Kunz, Ludvík; Svoboda, Milan

    2002-01-01

    Roč. 93, č. 7 (2002), s. 661-665 ISSN 0044-3093 R&D Projects: GA AV ČR IAA2041002; GA AV ČR KSK1010104 Institutional research plan: CEZ:AV0Z2041904 Keywords : Single crystals * Creep/fatigue interaction * Persistent slip bands Subject RIV: JL - Materials Fatigue, Friction Mechanics Impact factor: 0.636, year: 2002

  6. Coefficient of Performance Optimization of Single-Effect Lithium-Bromide Absorption Cycle Heat Pumps

    DEFF Research Database (Denmark)

    Vinther, Kasper; Just Nielsen, Rene; Nielsen, Kirsten Mølgaard

    2015-01-01

    In this paper, we investigate the coefficient of performance (COP) of a LiBr absorption cycle heat pump under different operating conditions. The investigation is carried out using a dynamical model fitted against data recorded from an actual heat pump used for district heating in S......⊘nderborg, Denmark. Since the model is too complex to study analytically, we vary different input variables within the permissible operating range of the heat pump and evaluate COP at the resulting steady-state operating points. It is found that the best set-point for each individual input is located at an extreme......-state operation of the heat pump, while avoiding crystallization issues....

  7. Multiple thrombophilic single nucleotide polymorphisms lack a significant effect on outcomes in fresh IVF cycles: an analysis of 1717 patients.

    Science.gov (United States)

    Patounakis, George; Bergh, Eric; Forman, Eric J; Tao, Xin; Lonczak, Agnieszka; Franasiak, Jason M; Treff, Nathan; Scott, Richard T

    2016-01-01

    The aim of the study is to determine if thrombophilic single nucleotide polymorphisms (SNPs) affect outcomes in fresh in vitro fertilization (IVF) cycles in a large general infertility population. A prospective cohort analysis was performed at a university-affiliated private IVF center of female patients undergoing fresh non-donor IVF cycles. The effect of the following thrombophilic SNPs on IVF outcomes were explored: factor V (Leiden and H1299R), prothrombin (G20210A), factor XIII (V34L), β-fibrinogen (-455G → A), plasminogen activator inhibitor-1 (4G/5G), human platelet antigen-1 (a/b9L33P), and methylenetetrahydrofolate reductase (C677T and A1298C). The main outcome measures included positive pregnancy test, clinical pregnancy, embryo implantation, live birth, and pregnancy loss. Patients (1717) were enrolled in the study, and a total of 4169 embryos were transferred. There were no statistically significant differences in positive pregnancy test, clinical pregnancy, embryo implantation, live birth, or pregnancy loss in the analysis of 1717 patients attempting their first cycle of IVF. Receiver operator characteristics and logistic regression analyses showed that outcomes cannot be predicted by the cumulative number of thrombophilic mutations present in the patient. Individual and cumulative thrombophilic SNPs do not affect IVF outcomes. Therefore, initial screening for these SNPs is not indicated.

  8. Dynamic single-cell NAD(P)H measurement reveals oscillatory metabolism throughout the E. coli cell division cycle.

    Science.gov (United States)

    Zhang, Zheng; Milias-Argeitis, Andreas; Heinemann, Matthias

    2018-02-01

    Recent work has shown that metabolism between individual bacterial cells in an otherwise isogenetic population can be different. To investigate such heterogeneity, experimental methods to zoom into the metabolism of individual cells are required. To this end, the autofluoresence of the redox cofactors NADH and NADPH offers great potential for single-cell dynamic NAD(P)H measurements. However, NAD(P)H excitation requires UV light, which can cause cell damage. In this work, we developed a method for time-lapse NAD(P)H imaging in single E. coli cells. Our method combines a setup with reduced background emission, UV-enhanced microscopy equipment and optimized exposure settings, overall generating acceptable NAD(P)H signals from single cells, with minimal negative effect on cell growth. Through different experiments, in which we perturb E. coli's redox metabolism, we demonstrated that the acquired fluorescence signal indeed corresponds to NAD(P)H. Using this new method, for the first time, we report that intracellular NAD(P)H levels oscillate along the bacterial cell division cycle. The developed method for dynamic measurement of NAD(P)H in single bacterial cells will be an important tool to zoom into metabolism of individual cells.

  9. Substructure based modeling of nickel single crystals cycled at low plastic strain amplitudes

    Science.gov (United States)

    Zhou, Dong

    In this dissertation a meso-scale, substructure-based, composite single crystal model is fully developed from the simple uniaxial model to the 3-D finite element method (FEM) model with explicit substructures and further with substructure evolution parameters, to simulate the completely reversed, strain controlled, low plastic strain amplitude cyclic deformation of nickel single crystals. Rate-dependent viscoplasticity and Armstrong-Frederick type kinematic hardening rules are applied to substructures on slip systems in the model to describe the kinematic hardening behavior of crystals. Three explicit substructure components are assumed in the composite single crystal model, namely "loop patches" and "channels" which are aligned in parallel in a "vein matrix," and persistent slip bands (PSBs) connected in series with the vein matrix. A magnetic domain rotation model is presented to describe the reverse magnetostriction of single crystal nickel. Kinematic hardening parameters are obtained by fitting responses to experimental data in the uniaxial model, and the validity of uniaxial assumption is verified in the 3-D FEM model with explicit substructures. With information gathered from experiments, all control parameters in the model including hardening parameters, volume fraction of loop patches and PSBs, and variation of Young's modulus etc. are correlated to cumulative plastic strain and/or plastic strain amplitude; and the whole cyclic deformation history of single crystal nickel at low plastic strain amplitudes is simulated in the uniaxial model. Then these parameters are implanted in the 3-D FEM model to simulate the formation of PSB bands. A resolved shear stress criterion is set to trigger the formation of PSBs, and stress perturbation in the specimen is obtained by several elements assigned with PSB material properties a priori. Displacement increment, plastic strain amplitude control and overall stress-strain monitor and output are carried out in the user

  10. Uranium, Plutonium and Neptunium Co-recovery with Irradiated Fast Reactor MOX Fuel by Single Cycle Extraction Process

    Energy Technology Data Exchange (ETDEWEB)

    Masaumi Nakahara; Yuichi Sano; Kazunori Nomura; Tadahiro Washiya; Jun Komaki [Japan Atomic Energy Agency, 4-33 Muramatsu, Tokai-mura, Naka-gun, Ibaraki, 319-1194 (Japan)

    2008-07-01

    The behavior of Np in single cycle extraction processes using tri-n-butylphosphate (TBP) as an extractant for U, Pu and Np co-recovery was investigated as a part of NEXT (New Extraction System for Transuranium) process. Two approaches for Np co-recovery with U and Pu were carried out with irradiated MOX fuel from fast reactor 'JOYO'; one was the counter current experiment using a feed solution with a high HNO{sub 3} concentration and the other used a scrubbing solution with a high HNO{sub 3} concentration. Experimental results showed that the leakage of Np to the raffinate were 0.986 % and 5.96 % under the condition of high HNO{sub 3} concentration in the feed solution and scrubbing solution, respectively. The simulation results based on these experiments indicated that most of Np could be extracted and co-recovered with U and Pu, just by increasing HNO{sub 3} concentrations in the feed and scrubbing solution on the single cycle extraction process. (authors)

  11. Benefits of high gradient solidification for creep and low cycle fatigue of AM1 single crystal superalloy

    Energy Technology Data Exchange (ETDEWEB)

    Steuer, S., E-mail: Susanne.Steuer@ensma.fr [Institut Pprime, CNRS – ENSMA – Université de Poitiers, UPR CNRS 3346, Department of Physics and Mechanics of Materials, ENSMA – Téléport 2, 1 avenue Clément Ader, BP 40109, 86961 Futuroscope Chasseneuil Cedex (France); Villechaise, P. [Institut Pprime, CNRS – ENSMA – Université de Poitiers, UPR CNRS 3346, Department of Physics and Mechanics of Materials, ENSMA – Téléport 2, 1 avenue Clément Ader, BP 40109, 86961 Futuroscope Chasseneuil Cedex (France); Pollock, T.M. [Materials Department, University of California Santa Barbara, Santa Barbara, CA 93106-5050 (United States); Cormier, J. [Institut Pprime, CNRS – ENSMA – Université de Poitiers, UPR CNRS 3346, Department of Physics and Mechanics of Materials, ENSMA – Téléport 2, 1 avenue Clément Ader, BP 40109, 86961 Futuroscope Chasseneuil Cedex (France)

    2015-10-01

    The influence of high thermal gradient processing on the creep and low cycle fatigue properties of the AM1 Ni-based single crystal superalloy has been studied. Isothermal creep (from 750 °C up to 1200 °C) and low cycle fatigue (750 °C and 950 °C) experiments were performed for AM1 alloy solidified with a conventional radiation cooled (Bridgman) and higher thermal gradient liquid-metal cooled (LMC) casting process to produce coarse and finer-scaled dendritic structures, respectively. There was no significant effect of the casting technique on creep properties, due to the very similar microstructures (γ′-size and γ-channel width) established after full heat treatment of both Bridgman and LMC samples. For low cycle fatigue properties, the benefit of the higher gradient LMC process was dependent on the testing temperature. At 750 °C, cracks primarily initiated at pores created by solidification shrinkage in both Bridgman and LMC samples. Samples produced by the LMC technique demonstrated fatigue lives up to 4 times longer, compared to the Bridgman samples, due to refined porosity. At 950 °C the low cycle fatigue properties of the LMC and conventionally solidified material were not distinguishable due to a shift of crack initiation sites from internal pores to oxidized surface layers or near-surface pores. The benefit of the LMC approach was, however, apparent in fatigue at 950 °C when testing in a vacuum environment. Based on these results, a crack initiation model based on the local slip activity close to casting defect is proposed.

  12. A road map for the realization of global-scale thorium breeding fuel cycle by single molten-fluoride flow

    International Nuclear Information System (INIS)

    Furukawa, K.; Arakawa, K.; Erbay, L. B.

    2007-01-01

    For global survival in this century, we urgently need to launch a completely new global nuclear fission industry. To get worldwide public acceptance of nuclear energy, improvements are essential not only on safety, radio-waste management and economy but also especially nuclear proliferation resistance and safeguards. However, such global fission industry cannot replace the present fossil fuel industry in the next 50 years, unless the doubling-time of nuclear energy is less than 10 years, preferably 5-7 years. Such a doubling-time cannot be established by any kind of classical 'Fission Breeding Power Station' concept. We need a symbiotic system which couples fission power reactors with a system which can convert fertile thorium to fissile U-233, such as a spallation or D/T fusion (if and when it becomes available). For such a purpose, THORIMS-NES [Thorium Molten-Salt Nuclear Energy Synergetic System] has been proposed, which is composed of simple thermal fission power stations (FUJI) and fissile producing Accelerator Molten-Salt Breeder (AMSB). Its system functions are very ambitious, delicate and complex, but can be realized in the form of simple hardware applying the multifunctional 'single-phase molten-fluoride' circulation system. This system has no difficulties relating with 'radiation-damage', 'heat-removal' and 'chemical processing' owing to the simple 'idealistic ionic liquid' character. FUJI is size-flexible (economical even in smaller sizes), fuel self-sustaining without any continuous chemical processing and without core-graphite replacement, and AMSB is based on a single-fluid molten-salt target/blanket concept, which solves most engineering difficulties such as radiation-damage, heat-removal etc., except high-current proton accelerator development. Several AMSBs are accommodated in the regional centers (several ten sites in the world) with batch chemical processing plants including radio-waste management. The integrated thorium breeding fuel cycle is

  13. Sorting of cells of the same size, shape, and cell cycle stage for a single cell level assay without staining

    Directory of Open Access Journals (Sweden)

    Yomo Tetsuya

    2006-06-01

    Full Text Available Abstract Background Single-cell level studies are being used increasingly to measure cell properties not directly observable in a cell population. High-performance data acquisition systems for such studies have, by necessity, developed in synchrony. However, improvements in sample purification techniques are also required to reveal new phenomena. Here we assessed a cell sorter as a sample-pretreatment tool for a single-cell level assay. A cell sorter is routinely used for selecting one type of cells from a heterogeneous mixture of cells using specific fluorescence labels. In this case, we wanted to select cells of exactly the same size, shape, and cell-cycle stage from a population, without using a specific fluorescence label. Results We used four light scatter parameters: the peak height and area of the forward scatter (FSheight and FSarea and side scatter (SSheight and SSarea. The rat pheochromocytoma PC12 cell line, a neuronal cell line, was used for all experiments. The living cells concentrated in the high FSarea and middle SSheight/SSarea fractions. Single cells without cell clumps were concentrated in the low SS and middle FS fractions, and in the higher FSheight/FSarea and SSheight/SSarea fractions. The cell populations from these viable, single-cell-rich fractions were divided into twelve subfractions based on their FSarea-SSarea profiles, for more detailed analysis. We found that SSarea was proportional to the cell volume and the FSarea correlated with cell roundness and elongation, as well as with the level of DNA in the cell. To test the method and to characterize the basic properties of the isolated single cells, sorted cells were cultured in separate wells. The cells in all subfractions survived, proliferated and differentiated normally, suggesting that there was no serious damage. The smallest, roundest, and smoothest cells had the highest viability. There was no correlation between proliferation and differentiation. NGF increases

  14. Preferences of subfertile women regarding elective single embryo transfer: additional in vitro fertilization cycles are acceptable, lower pregnancy rates are not

    NARCIS (Netherlands)

    Twisk, Moniek; van der Veen, Fulco; Repping, Sjoerd; Heineman, Maas-Jan; Korevaar, Johanna C.; Bossuyt, Patrick M. M.

    2007-01-01

    With identical pregnancy rates after elective single embryo transfer (ET) and double ET strategies consisting of three cycles of IVF or intracytoplasmic sperm injection (ICSI) plus transfers of thawed/frozen embryos if available, 46% of the women undergoing IVF/ICSI favor elective single ET. If

  15. Preferences of subfertile women regarding elective single embryo transfer : additional in vitro fertilization cycles are acceptable, lower pregnancy rates are not

    NARCIS (Netherlands)

    Twisk, Moniek; van der Veen, Fulco; Repping, Sjoerd; Heineman, Maas-Jan; Korevaar, Johanna C.; Bossuyt, Patrick M. M.

    2007-01-01

    With identical pregnancy rates after elective single embryo transfer (ET) and double ET strategies consisting of three cycles of IVF or intracytoplasmic sperm injection (ICSI) plus transfers of thawed/frozen embryos if available, 46% of the women undergoing IVF/ICSI favor elective single ET. If

  16. Effects of single cycle binaural beat duration on auditory evoked potentials.

    Science.gov (United States)

    Mihajloski, Todor; Bohorquez, Jorge; Özdamar, Özcan

    2014-01-01

    Binaural beat (BB) illusions are experienced as continuous central pulsations when two sounds with slightly different frequencies are delivered to each ear. It has been shown that steady-state auditory evoked potentials (AEPs) to BBs can be captured and investigated. The authors recently developed a new method of evoking transient AEPs to binaural beats using frequency modulated stimuli. This methodology was able to create single BBs in predetermined intervals with varying carrier frequencies. This study examines the effects of the BB duration and the frequency modulating component of the stimulus on the binaural beats and their evoked potentials. Normal hearing subjects were tested with a set of four durations (25, 50, 100, and 200 ms) with two stimulation configurations, binaural dichotic (binaural beats) and diotic (frequency modulation). The results obtained from the study showed that out of the given durations, the 100 ms beat, was capable of evoking the largest amplitude responses. The frequency modulation effect showed a decrease in peak amplitudes with increasing beat duration until their complete disappearance at 200 ms. Even though, at 200 ms, the frequency modulation effects were not present, the binaural beats were still perceived and captured as evoked potentials.

  17. Association between ABO blood type and live-birth outcomes in single-embryo transfer cycles.

    Science.gov (United States)

    Pereira, Nigel; Patel, Hency H; Stone, Logan D; Christos, Paul J; Elias, Rony T; Spandorfer, Steven D; Rosenwaks, Zev

    2017-11-01

    To investigate the association between ABO blood type and live-birth outcomes in patients undergoing IVF with day 5 single-embryo transfer (SET). Retrospective cohort study. University-affiliated center. Normal responders, blood type and live birth, while controlling for confounders. Odds ratios (OR) with 95% confidence intervals (CI) for live birth were estimated. A total of 2,329 patients were included. The mean age of the study cohort was 34.6 ± 4.78 years. The distribution of blood types was as follows: A = 897 (38.5%); B = 397 (17.0%); AB = 120 (5.2%); and, O = 1,915 (39.3%) patients. There was no difference in the baseline demographics, ovarian stimulation, or embryo quality parameters between the blood types. The unadjusted ORs for live birth when comparing blood type A (referent) with blood types B, AB, and O were 0.96 (95% CI, 0.6-1.7), 0.72 (95% CI, 0.4-1.2), and 0.96 (95% CI. 0.6-1.7), respectively. The adjusted ORs for live birth remained not significant when comparing blood type A to blood types B, AB, and O individually. No difference in birth weight or gestational age at delivery was noted among the four blood types. Our findings suggest that ABO blood type is not associated with live-birth rate, birth weight, or gestational age at delivery in patients undergoing IVF with day 5 SET. Copyright © 2017 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  18. High spin cycles: topping the spin record for a single molecule verging on quantum criticality

    Science.gov (United States)

    Baniodeh, Amer; Magnani, Nicola; Lan, Yanhua; Buth, Gernot; Anson, Christopher E.; Richter, Johannes; Affronte, Marco; Schnack, Jürgen; Powell, Annie K.

    2018-03-01

    The cyclisation of a short chain into a ring provides fascinating scenarios in terms of transforming a finite array of spins into a quasi-infinite structure. If frustration is present, theory predicts interesting quantum critical points, where the ground state and thus low-temperature properties of a material change drastically upon even a small variation of appropriate external parameters. This can be visualised as achieving a very high and pointed summit where the way down has an infinity of possibilities, which by any parameter change will be rapidly chosen, in order to reach the final ground state. Here we report a mixed 3d/4f cyclic coordination cluster that turns out to be very near or even at such a quantum critical point. It has a ground state spin of S = 60, the largest ever observed for a molecule (120 times that of a single electron). [Fe10Gd10(Me-tea)10(Me-teaH)10(NO3)10].20MeCN forms a nano-torus with alternating gadolinium and iron ions with a nearest neighbour Fe-Gd coupling and a frustrating next-nearest neighbour Fe-Fe coupling. Such a spin arrangement corresponds to a cyclic delta or saw-tooth chain, which can exhibit unusual frustration effects. In the present case, the quantum critical point bears a `flatland' of tens of thousands of energetically degenerate states between which transitions are possible at no energy costs with profound caloric consequences. Entropy-wise the energy flatland translates into the pointed summit overlooking the entropy landscape. Going downhill several target states can be reached depending on the applied physical procedure which offers new prospects for addressability.

  19. Interference Canceller Based on Cycle-and-Add Property for Single User Detection in DS-CDMA

    Science.gov (United States)

    Hettiarachchi, Ranga; Yokoyama, Mitsuo; Uehara, Hideyuki; Ohira, Takashi

    In this paper, performance of a novel interference cancellation technique for the single user detection in a direct-sequence code-division multiple access (DS-CDMA) system has been investigated. This new algorithm is based on the Cycle-and-Add property of PN (Pseudorandom Noise) sequences and can be applied for both synchronous and asynchronous systems. The proposed strategy provides a simple method that can delete interference signals one by one in spite of the power levels of interferences. Therefore, it is possible to overcome the near-far problem (NFP) in a successive manner without using transmit power control (TPC) techniques. The validity of the proposed procedure is corroborated by computer simulations in additive white Gaussian noise (AWGN) and frequency-nonselective fading channels. Performance results indicate that the proposed receiver outperforms the conventional receiver and, in many cases, it does so with a considerable gain.

  20. Thermal and pseudoelastic cycling in Cu-14.1Al-4.2Ni (wt%) single crystals

    International Nuclear Information System (INIS)

    Gastien, R.; Corbellani, C.E.; Sade, M.; Lovey, F.C.

    2005-01-01

    Thermally and stress induced martensitic transformations between β and a mixture of martensitic structures, β' and γ', were studied in Cu-14.1Al-4.2Ni (wt%) single crystals. In this way information on the relative stability between β' and γ' martensites, compared to the β phase, was obtained. The measurement of electrical resistance as a function of temperature was used to follow the evolution of thermally induced transitions. The stress induced transformations were analyzed in the small temperature range at which the pseudoelastic behavior between β and a mixture of both martensites plays the main role. A clear inhibition of the γ' martensite is detected as the number of cycles increases, no matter which thermodynamic coordinate is varied to induce the phase transition, i.e., temperature or stress. An evaluation of the magnitude of the relative stabilization of the β' martensite compared with γ' was obtained by a suitably designed experiment

  1. Disabled infectious single cycle-herpes simplex virus (DISC-HSV) as a vector for immunogene therapy of cancer.

    Science.gov (United States)

    Rees, Robert C; McArdle, Stephanie; Mian, Shahid; Li, Geng; Ahmad, Murrium; Parkinson, Richard; Ali, Selman A

    2002-02-01

    Disabled infectious single cycle-herpes simplex viruses (DISC-HSV) have been shown to be safe for use in humans and may be considered efficacious as vectors for immunogene therapy in cancer. Preclinical studies show that DISC-HSV is an efficient delivery system for cytokine genes and antigens. DISC-HSV infects a high proportion of cells, resulting in rapid gene expression for at least 72 h. The DISC-HSV-mGM-CSF vector, when inoculated into tumors, induces tumor regression in a high percentage of animals, concomitant with establishing a cytotoxic T-cell response, which is MHC class I restricted and directed against peptides of known tumor antigens. The inherent properties of DISC-HSV makes it a suitable vector for consideration in human immunogene therapy trials.

  2. Comparative analysis of methods for integrating various environmental impacts as a single index in life cycle assessment

    International Nuclear Information System (INIS)

    Ji, Changyoon; Hong, Taehoon

    2016-01-01

    Previous studies have proposed several methods for integrating characterized environmental impacts as a single index in life cycle assessment. Each of them, however, may lead to different results. This study presents internal and external normalization methods, weighting factors proposed by panel methods, and a monetary valuation based on an endpoint life cycle impact assessment method as the integration methods. Furthermore, this study investigates the differences among the integration methods and identifies the causes of the differences through a case study in which five elementary school buildings were used. As a result, when using internal normalization with weighting factors, the weighting factors had a significant influence on the total environmental impacts whereas the normalization had little influence on the total environmental impacts. When using external normalization with weighting factors, the normalization had more significant influence on the total environmental impacts than weighing factors. Due to such differences, the ranking of the five buildings varied depending on the integration methods. The ranking calculated by the monetary valuation method was significantly different from that calculated by the normalization and weighting process. The results aid decision makers in understanding the differences among these integration methods, and, finally, help them select the method most appropriate for the goal at hand.

  3. Comparative analysis of methods for integrating various environmental impacts as a single index in life cycle assessment

    Energy Technology Data Exchange (ETDEWEB)

    Ji, Changyoon, E-mail: changyoon@yonsei.ac.kr; Hong, Taehoon, E-mail: hong7@yonsei.ac.kr

    2016-02-15

    Previous studies have proposed several methods for integrating characterized environmental impacts as a single index in life cycle assessment. Each of them, however, may lead to different results. This study presents internal and external normalization methods, weighting factors proposed by panel methods, and a monetary valuation based on an endpoint life cycle impact assessment method as the integration methods. Furthermore, this study investigates the differences among the integration methods and identifies the causes of the differences through a case study in which five elementary school buildings were used. As a result, when using internal normalization with weighting factors, the weighting factors had a significant influence on the total environmental impacts whereas the normalization had little influence on the total environmental impacts. When using external normalization with weighting factors, the normalization had more significant influence on the total environmental impacts than weighing factors. Due to such differences, the ranking of the five buildings varied depending on the integration methods. The ranking calculated by the monetary valuation method was significantly different from that calculated by the normalization and weighting process. The results aid decision makers in understanding the differences among these integration methods, and, finally, help them select the method most appropriate for the goal at hand.

  4. Optimizing the performance of small-scale organic Rankine cycle that utilizes a single-screw expander

    International Nuclear Information System (INIS)

    Ziviani, D.; Gusev, S.; Lecompte, S.; Groll, E.A.; Braun, J.E.; Horton, W.T.; Broek, M. van den; De Paepe, M.

    2017-01-01

    Highlights: • A total of 102 steady-state points with R245fa and SES336 have been collected. • R245fa led to 10% higher power output despite lower expander isentropic efficiency. • The ORC running with SES36 presented a better matching between expander and cycle. • The theoretical matching between expander volume ratio and cycle efficiency is determined. • Steady-state performance maps are used to build a feed-forward controller. - Abstract: This paper deals with the operation and optimization of a down-scaled industrial organic Rankine cycle (ORC) for low-grade waste heat recovery. The system is a sub-critical regenerative ORC with a nominal power output of 11 kW. The ORC unit has been assembled using off-the-shelf components including three identical plate heat exchangers, a liquid receiver, a multi-stage centrifugal pump and a single-screw compressor adapted to operate as an expander. The experimental results are used to evaluate the influence of the expander performance on the behavior of the ORC system at nominal and part-load conditions. The matching between the volumetric expander and the system operating conditions is also analyzed. Results showed that in the case of SES36, both the expander efficiency and system performance were maximized for a pressure ratio between 7 and 9. In the case of R245fa, while the system efficiency achieved values similar to SES36, but the expander maximum isentropic efficiency was 17% lower. Two analyses are carried out to optimize the operation of the ORC unit with R245fa. At first, the insights gained by analyzing the experimental data are used to evaluate the theoretical matching between volumetric expander and the system maximum efficiency in terms of the Second Law of thermodynamics. Secondly, a control-oriented steady-state cycle model based on empirical correlations calibrated on the experimental results is developed. The model is used to implement a feed-forward control strategy based on predetermined steady

  5. Analysis of trace inorganic anions in weak acid salts by single pump cycling-column-switching ion chromatography.

    Science.gov (United States)

    Huang, Zhongping; Ni, Chengzhu; Zhu, Zhuyi; Pan, Zaifa; Wang, Lili; Zhu, Yan

    2015-05-01

    The application of ion chromatography with the single pump cycling-column-switching technique was described for the analysis of trace inorganic anions in weak acid salts within a single run. Due to the hydrogen ions provided by an anion suppressor electrolyzing water, weak acid anions could be transformed into weak acids, existing as molecules, after passing through the suppressor. Therefore, an anion suppressor and ion-exclusion column were adopted to achieve on-line matrix elimination of weak acid anions with high concentration for the analysis of trace inorganic anions in weak acid salts. A series of standard solutions consisting of target anions of various concentrations from 0.005 to 10 mg/L were analyzed, with correlation coefficients r ≥ 0.9990. The limits of detection were in the range of 0.67 to 1.51 μg/L, based on the signal-to-noise ratio of 3 and a 25 μL injection volume. Relative standard deviations for retention time, peak area, and peak height were all less than 2.01%. A spiking study was performed with satisfactory recoveries between 90.3 and 104.4% for all anions. The chromatographic system was successfully applied to the analysis of trace inorganic anions in five weak acid salts. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Life Cycle Assessment and Costing Methods for Device Procurement: Comparing Reusable and Single-Use Disposable Laryngoscopes.

    Science.gov (United States)

    Sherman, Jodi D; Raibley, Lewis A; Eckelman, Matthew J

    2018-01-09

    Traditional medical device procurement criteria include efficacy and safety, ease of use and handling, and procurement costs. However, little information is available about life cycle environmental impacts of the production, use, and disposal of medical devices, or about costs incurred after purchase. Reusable and disposable laryngoscopes are of current interest to anesthesiologists. Facing mounting pressure to quickly meet or exceed conflicting infection prevention guidelines and oversight body recommendations, many institutions may be electively switching to single-use disposable (SUD) rigid laryngoscopes or overcleaning reusables, potentially increasing both costs and waste generation. This study provides quantitative comparisons of environmental impacts and total cost of ownership among laryngoscope options, which can aid procurement decision making to benefit facilities and public health. We describe cradle-to-grave life cycle assessment (LCA) and life cycle costing (LCC) methods and apply these to reusable and SUD metal and plastic laryngoscope handles and tongue blade alternatives at Yale-New Haven Hospital (YNHH). The US Environmental Protection Agency's Tool for the Reduction and Assessment of Chemical and other environmental Impacts (TRACI) life cycle impact assessment method was used to model environmental impacts of greenhouse gases and other pollutant emissions. The SUD plastic handle generates an estimated 16-18 times more life cycle carbon dioxide equivalents (CO2-eq) than traditional low-level disinfection of the reusable steel handle. The SUD plastic tongue blade generates an estimated 5-6 times more CO2-eq than the reusable steel blade treated with high-level disinfection. SUD metal components generated much higher emissions than all alternatives. Both the SUD handle and SUD blade increased life cycle costs compared to the various reusable cleaning scenarios at YNHH. When extrapolated over 1 year (60,000 intubations), estimated costs increased

  7. Anticancer effects of kaempferol in A375 human malignant melanoma cells are mediated via induction of apoptosis, cell cycle arrest, inhibition of cell migration and downregulation of m-TOR/PI3K/AKT pathway.

    Science.gov (United States)

    Yang, Jia; Xiao, Peng; Sun, Jiaming; Guo, Liang

    2018-01-01

    Melanoma is an aggressive form of human cancer with limited treatment options currently available. The present study was aimed to evaluate the anticancer activity of kaempferol (KAM) against the human malignant melanoma A375 cell line along with evaluation of its effects on apoptosis, cell cycle, cell migration and m-TOR/PI3K/AKT pathway. Effects on cell viability were assessed by MTT assay while clonogenic assay measured the effects of KAM on colony formation. Annexin V assay evaluated the apoptotic effects of KAM in these cells using flow cytometry. Effects on cell cycle were determined by using flow cytometry with propidium iodide (PI) as probe. The effects of KAM on m-TOR/ PI3K/AKT signalling pathway were evaluated by western blot assay. MTT assay indicated that KAM exhibits a significant anticancer activity against A375 cells with an IC50 of 20 μM. These antiproliferative effects of KAM were also supported by the colony formation assay wherein KAM reduced the colony formation in a dose-dependent manner. The anticancer effect of KAM was found to be due to the initiation of apoptosis in human malignant melanoma A375 cells. Additionally, KAM also exhibited the capacity to trigger G2/M cell cycle arrest and to inhibit the cell migratory potential of A375 cells. KAM caused significant downregulation of m-TOR, phosphorylated (p) m-TOR, PI3K, p-PI3K and Akt protein levels in A375 malignantmelanoma cells. KAM exerts potent anticancer effects via induction of apoptosis, G2/M cell cycle arrest, cell migration inhibition and downregulation of m-TOR, pm-TOR, PI3K, p-PI3K and Akt protein levels.

  8. Effect of single- and two-cycle high hydrostatic pressure treatments on water properties, physicochemical and microbial qualities of minimally processed squids (todarodes pacificus).

    Science.gov (United States)

    Zhang, Yifeng; Jiao, Shunshan; Lian, Zixuan; Deng, Yun; Zhao, Yanyun

    2015-05-01

    This study investigated the effect of single- and two-cycle high hydrostatic pressure (HHP) treatments on water properties, physicochemical, and microbial qualities of squids (Todarodes pacificus) during 4 °C storage for up to 10 d. Single-cycle treatments were applied at 200, 400, or 600 MPa for 20 min (S-200, S-400, and S-600), and two-cycle treatments consisted of two 10 min cycles at 200, 400, or 600 MPa, respectively (T-200, T-400, and T-600). HHP-treated samples had higher (P pressure level caused no significant difference in water state of squids. The two-cycle HHP treatment was more effective in controlling total volatile basic nitrogen, pH, and total plate counts (TPC) of squids during storage, in which TPC of S-600 and T-600 was 2.9 and 1.8 log CFU/g at 10 d, respectively, compared with 7.5 log CFU/g in control. HHP treatments delayed browning discoloration of the squids during storage, and the higher pressure level and two-cycle HHP were more effective. Water properties highly corresponded with color and texture indices of squids. This study demonstrated that the two-cycle HHP treatment was more effective in controlling microbial growth and quality deterioration while having similar impact on the physicochemical and water properties of squids in comparison with the single-cycle treatment, thus more desirable for extending shelf-life of fresh squids. © 2015 Institute of Food Technologists®

  9. A study on density functional theory of the effect of pressure on the formation and migration enthalpies of intrinsic point defects in growing single crystal Si

    Science.gov (United States)

    Sueoka, Koji; Kamiyama, Eiji; Kariyazaki, Hiroaki

    2012-05-01

    In 1982, Voronkov presented a model describing point defect behavior during the growth of single crystal Si from a melt and derived an expression to predict if the crystal was vacancy- or self-interstitial-rich. Recently, Vanhellemont claimed that one should take into account the impact of compressive stress introduced by the thermal gradient at the melt/solid interface by considering the hydrostatic pressure dependence of the formation enthalpy of the intrinsic point defects. To evaluate the impact of thermal stress more correctly, the pressure dependence of both the formation enthalpy (Hf) and the migration enthalpy (Hm) of the intrinsic point defects should be taken into account. Furthermore, growing single crystal Si is not under hydrostatic pressure but almost free of external pressure (generally in Ar gas under reduced pressure). In the present paper, the dependence of Hf and Hm on the pressure P, or in other words, the pressure dependence of the formation energy (Ef) and the relaxation volume (vf), is quantified by density functional theory calculations. Although a large number of ab initio calculations of the properties of intrinsic point defects have been published during the last years, calculations for Si crystals under pressure are rather scarce. For vacancies V, the reported pressure dependences of HfV are inconsistent. In the present study, by using 216-atom supercells with a sufficient cut-off energy and mesh of k-points, the neutral I and V are found to have nearly constant formation energies EfI and EfV for pressures up to 1 GPa. For the relaxation volume, vfI is almost constant while vfV decreases linearly with increasing pressure P. In case of the hydrostatic pressure Ph, the calculated formation enthalpy HfI and migration enthalpy HmI at the [110] dumbbell site are given by HfI = 3.425 - 0.057 × Ph (eV) and HmI = 0.981 - 0.039 × Ph (eV), respectively, with Ph given in GPa. The calculated HfV and HmV dependencies on Ph given by HfV = 3.543 - 0

  10. A critical survey of live virtual machine migration techniques

    Directory of Open Access Journals (Sweden)

    Anita Choudhary

    2017-11-01

    Full Text Available Abstract Virtualization techniques effectively handle the growing demand for computing, storage, and communication resources in large-scale Cloud Data Centers (CDC. It helps to achieve different resource management objectives like load balancing, online system maintenance, proactive fault tolerance, power management, and resource sharing through Virtual Machine (VM migration. VM migration is a resource-intensive procedure as VM’s continuously demand appropriate CPU cycles, cache memory, memory capacity, and communication bandwidth. Therefore, this process degrades the performance of running applications and adversely affects efficiency of the data centers, particularly when Service Level Agreements (SLA and critical business objectives are to be met. Live VM migration is frequently used because it allows the availability of application service, while migration is performed. In this paper, we make an exhaustive survey of the literature on live VM migration and analyze the various proposed mechanisms. We first classify the types of Live VM migration (single, multiple and hybrid. Next, we categorize VM migration techniques based on duplication mechanisms (replication, de-duplication, redundancy, and compression and awareness of context (dependency, soft page, dirty page, and page fault and evaluate the various Live VM migration techniques. We discuss various performance metrics like application service downtime, total migration time and amount of data transferred. CPU, memory and storage data is transferred during the process of VM migration and we identify the category of data that needs to be transferred in each case. We present a brief discussion on security threats in live VM migration and categories them in three different classes (control plane, data plane, and migration module. We also explain the security requirements and existing solutions to mitigate possible attacks. Specific gaps are identified and the research challenges in improving

  11. Pepsin-solubilised collagen (PSC) from Red Sea cucumber (Stichopus japonicus) regulates cell cycle and the fibronectin synthesis in HaCaT cell migration.

    Science.gov (United States)

    Park, Soo-Yeong; Lim, Hee Kyoung; Lee, Seogjae; Hwang, Hyeong Cheol; Cho, Somi K; Cho, Moonjae

    2012-05-01

    Pepsin-solubilised collagen (PSC) from Red Sea cucumber (Stichopus japonicus) was studied with respect to its wound-healing effects on a human keratinocyte (HaCaT) cell line. Disaggregated collagen fibres were treated with 0.1M NaOH for 24h and digested with pepsin for 72h to reach maximum yield of 26.6%. The results of an in vitro wound-healing test showed that migration of HaCaT cells was 1.5-fold faster on PSC-coated plates than on untreated plates. The migration rate of sea cucumber PSC was similar to that of rat PSC, but five times higher than that of bovine gelatin. HaCaT cells grown on PSC-coated plates revealed increased fibronectin synthesis (6-fold and 3-fold compared to gelatin and rat PSC, respectively). Additionally, sea cucumber PSCs induced HaCaT cell proliferation by decreasing the G1 phase by 5% and maintaining a larger population (8%) of cells in mitosis. Collagen from Red Sea cucumber might be useful as an alternative to mammalian collagen in the nutraceutical and pharmaceutical industries. Copyright © 2011 Elsevier Ltd. All rights reserved.

  12. A review of findings of a study of rocket based combined cycle engines applied to extensively axisymmetric single stage to orbit vehicles

    Science.gov (United States)

    Foster, Richard W.

    1992-01-01

    Extensively axisymmetric and non-axisymmetric Single Stage To Orbit (SSTO) vehicles are considered. The information is presented in viewgraph form and the following topics are presented: payload comparisons; payload as a percent of dry weight - a system hardware cost indicator; life cycle cost estimations; operations and support costs estimation; selected engine type; and rocket engine specific impulse calculation.

  13. Patient and cycle characteristics predicting high pregnancy rates with single-embryo transfer: an analysis of the Society for Assisted Reproductive Technology outcomes between 2004 and 2013.

    Science.gov (United States)

    Mersereau, Jennifer; Stanhiser, Jamie; Coddington, Charles; Jones, Tiffany; Luke, Barbara; Brown, Morton B

    2017-11-01

    To analyze factors associated with high live birth rate and low multiple birth rate in fresh and frozen-thawed assisted reproductive technology (ART) cycles. Retrospective cohort analysis. Not applicable. The study population included 181,523 women undergoing in vitro fertilization with autologous fresh first cycles, 27,033 with fresh first oocyte donor cycles, 37,658 with fresh second cycles, and 35,446 with frozen-thawed second cycles. None. Live birth rate and multiple birth rate after single-embryo transfer (SET) and double embryo transfer (DET) were measured, in addition to cycle characteristics. In patients with favorable prognostic factors, including younger maternal age, transfer of a blastocyst, and additional embryos cryopreserved, the gain in the live birth rate from SET to DET was approximately 10%-15%; however, the multiple birth rate increased from approximately 2% to greater than 49% in both autologous and donor fresh and frozen-thawed transfer cycles. This study reports a 10%-15% reduction in live birth rate and a 47% decrement in multiple birth rate with SET compared with DET in the setting of favorable patient prognostic factors. Our findings present an opportunity to increase the rate of SET across the United States and thereby reduce the multiple birth rate and its associated poor perinatal outcomes with assisted reproductive technology pregnancies. Copyright © 2017 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  14. Oxide-assisted crack growth in hold-time low-cycle-fatigue of single-crystal superalloys

    Directory of Open Access Journals (Sweden)

    Suzuki Akane

    2014-01-01

    Full Text Available Compressive hold-time low-cycle fatigue is one of the important damage modes in Ni-based superalloy hot-gas path components. In strain controlled LCF, the compressive hold typically degrades fatigue life significantly due to creep relaxation and the resultant generation of tensile stress upon returning to zero strain. Crack initiation typically occurs on the surface, and therefore, the cracks are covered with layers of oxides. Recent finite element modeling based on experimental observations has indicated that the in-plane compressive stress in the alumina layer formed on the surface of the bond coat assists rumpling and, eventually, leads to initiation of cracks. The stress in the oxide layer continues to assist crack extension by pushing the alumina layer along the crack front during the compressive hold. In-situ measurements of the growth strains of alumina were performed using high energy synchrotron X-rays at Argonne National Lab. Specimens of single-crystal superalloys with and without aluminide coatings were statically pre-oxidized to form a layer of alumina at 1093 and 982 ∘C. For the in-situ synchrotron measurements, the specimens were heated up to the pre-oxidation temperatures with a heater. The alumina layers on both bare and coated specimens show compressive in-plane strains at both temperatures. The oxide strains on the superalloys showed dependency on temperature; on the other hand, the oxide strains in the aluminide coatings were insensitive to temperature. The magnitude of the compressive strains was larger on the superalloys than the ones on the aluminide coatings.

  15. Assessment of single nucleotide polymorphisms in screening 52 DNA repair and cell cycle control genes in Fanconi anemia patients

    Directory of Open Access Journals (Sweden)

    Petrović Sandra

    2015-01-01

    Full Text Available Fanconi anemia (FA is a rare genetically heterogeneous disorder associated with bone marrow failure, birth defects and cancer susceptibility. Apart from the disease- causing mutations in FANC genes, the identification of specific DNA variations, such as single nucleotide polymorphisms (SNPs, in other candidate genes may lead to a better clinical description of this condition enabling individualized treatment with improvement of the prognosis. In this study, we have assessed 95 SNPs located in 52 key genes involved in base excision repair (BER, nucleotide excision repair (NER, mismatch repair (MMR, double strand break (DSB repair and cell cycle control using a DNA repair chip (Asper Biotech, Estonia which includes most of the common variants for the candidate genes. The SNP genotyping was performed in five FA-D2 patients and in one FA-A patient. The polymorphisms studied were synonymous (n=10, nonsynonymous (missense (n=52 and in non-coding regions of the genome (introns and 5 ‘and 3’ untranslated regions (UTR (n=33. Polymorphisms found at the homozygous state are selected for further analysis. Our results have shown a significant inter-individual variability among patients in the type and the frequency of SNPs and also elucidate the need for further studies of polymorphisms located in ATM, APEX APE 1, XRCC1, ERCC2, MSH3, PARP4, NBS1, BARD1, CDKN1B, TP53 and TP53BP1 which may be of great importance for better clinical description of FA. In addition, the present report recommends the use of SNPs as predictive and prognostic genetic markers to individualize therapy of FA patients. [Projekat Ministarstva nauke Republike Srbije, br. 173046

  16. Controlled surface topography regulates collective 3D migration by epithelial-mesenchymal composite embryonic tissues.

    Science.gov (United States)

    Song, Jiho; Shawky, Joseph H; Kim, YongTae; Hazar, Melis; LeDuc, Philip R; Sitti, Metin; Davidson, Lance A

    2015-07-01

    Cells in tissues encounter a range of physical cues as they migrate. Probing single cell and collective migratory responses to physically defined three-dimensional (3D) microenvironments and the factors that modulate those responses are critical to understanding how tissue migration is regulated during development, regeneration, and cancer. One key physical factor that regulates cell migration is topography. Most studies on surface topography and cell mechanics have been carried out with single migratory cells, yet little is known about the spreading and motility response of 3D complex multi-cellular tissues to topographical cues. Here, we examine the response to complex topographical cues of microsurgically isolated tissue explants composed of epithelial and mesenchymal cell layers from naturally 3D organized embryos of the aquatic frog Xenopus laevis. We control topography using fabricated micropost arrays (MPAs) and investigate the collective 3D migration of these multi-cellular systems in these MPAs. We find that the topography regulates both collective and individual cell migration and that dense MPAs reduce but do not eliminate tissue spreading. By modulating cell size through the cell cycle inhibitor Mitomycin C or the spacing of the MPAs we uncover how 3D topographical cues disrupt collective cell migration. We find surface topography can direct both single cell motility and tissue spreading, altering tissue-scale processes that enable efficient conversion of single cell motility into collective movement. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Wages, Welfare Benefits and Migration.

    Science.gov (United States)

    Kennan, John; Walker, James R

    2010-05-01

    Differences in economic opportunities give rise to strong migration incentives, across regions within countries, and across countries. In this paper we focus on responses to differences in welfare benefits across States. We apply the model developed in Kennan and Walker (2008), which emphasizes that migration decisions are often reversed, and that many alternative locations must be considered. We model individual decisions to migrate as a job search problem. A worker starts the life-cycle in some home location and must determine the optimal sequence of moves before settling down. The model is sparsely parameterized. We estimate the model using data from the National Longitudinal Survey of Youth (1979). Our main finding is that income differences do help explain the migration decisions of young welfare-eligible women, but large differences in benefit levels provide surprisingly weak migration incentives.

  18. Low-cycle fatigue and damage of an uncoated and coated single crystal nickel-base superalloy SCB

    International Nuclear Information System (INIS)

    Stekovic, S.; Ericsson, T.

    2007-01-01

    This paper presents low-cycle fatigue (LCF) behaviour and damage mechanisms of uncoated and coated specimens of a single crystal nickel-base superalloy SCB tested at 500 C and 900 C. Four coatings were deposited on the base material, an overlay coating AMDRY997, a platinum-modified aluminide diffusion coating RT22 and two innovative coatings called IC1 and IC3 with a NiW diffusion barrier in the interface. AMDRY997 and RT22 were used as reference coatings. The LCF tests were performed at three strain amplitudes, 1.0, 1.2 and 1.4%, with R = -1, in laboratory air and without any dwell time. The LCF life of the specimens is determined by crack initiation and propagation. Crack data are presented for different classes of crack size in the form of crack density, that is, the number of cracks normalised to the investigated interface length. Micrographs of damage of the coatings are also shown. The effect of the coatings on the LCF life of the superalloy was dependent on the test temperature and deposited coating. At 500 C all coatings had a detrimental effect on the LCF life of the superalloy. At 900 C both AMDRY997 and IC1 prolonged the fatigue life of the superalloy by factors ranging between 1.5 and 4 while RT22 and IC3 shortened the life of the coating-substrate system. Specimens coated with RT22 exhibited generally more damage than other tested coatings at 900 C. Most of the cracks observed initiated at the coating surface and a majority were arrested in the interdiffusion zone between the base material and the coating. No topologically close-packed phases were found. Delamination was only found in AMDRY997 at higher strains. Surface roughness or rumpling was found in the overlay coating AMDRY997 with some cracks initiating from the rumples. The failure morphology at 900 C reflected the role of oxidation in the fatigue life, the crack initiation and propagation of the coated specimens. The wake of the cracks grown into the substrate was severely oxidised leading to

  19. Preliminary Sizing Completed for Single- Stage-To-Orbit Launch Vehicles Powered By Rocket-Based Combined Cycle Technology

    Science.gov (United States)

    Roche, Joseph M.

    2002-01-01

    Single-stage-to-orbit (SSTO) propulsion remains an elusive goal for launch vehicles. The physics of the problem is leading developers to a search for higher propulsion performance than is available with all-rocket power. Rocket-based combined cycle (RBCC) technology provides additional propulsion performance that may enable SSTO flight. Structural efficiency is also a major driving force in enabling SSTO flight. Increases in performance with RBCC propulsion are offset with the added size of the propulsion system. Geometrical considerations must be exploited to minimize the weight. Integration of the propulsion system with the vehicle must be carefully planned such that aeroperformance is not degraded and the air-breathing performance is enhanced. Consequently, the vehicle's structural architecture becomes one with the propulsion system architecture. Geometrical considerations applied to the integrated vehicle lead to low drag and high structural and volumetric efficiency. Sizing of the SSTO launch vehicle (GTX) is itself an elusive task. The weight of the vehicle depends strongly on the propellant required to meet the mission requirements. Changes in propellant requirements result in changes in the size of the vehicle, which in turn, affect the weight of the vehicle and change the propellant requirements. An iterative approach is necessary to size the vehicle to meet the flight requirements. GTX Sizer was developed to do exactly this. The governing geometry was built into a spreadsheet model along with scaling relationships. The scaling laws attempt to maintain structural integrity as the vehicle size is changed. Key aerodynamic relationships are maintained as the vehicle size is changed. The closed weight and center of gravity are displayed graphically on a plot of the synthesized vehicle. In addition, comprehensive tabular data of the subsystem weights and centers of gravity are generated. The model has been verified for accuracy with finite element analysis. The

  20. Short-term seaward fish migration in the Messolonghi Etoliko lagoons (Western Greek coast) in relation to climatic variables and the lunar cycle

    Science.gov (United States)

    Katselis, George; Koukou, Katerina; Dimitriou, Evagelos; Koutsikopoulos, Constantin

    2007-07-01

    In the present study we analysed the daily seaward migratory behaviour of four dominant euryhaline fish species (Mugilidae: Liza saliens, Liza aurata, Mugil cephalus and Sparidae: Sparus aurata) in the Messolonghi Etoliko lagoon system (Western Greek coast) based on the daily landings' time series of barrier traps and assessed the relationship between their migratory behaviour and various climatic variables (air temperature and atmospheric pressure) and the lunar cycle. A 2-year time series of daily fish landings (1993 and 1994), a long time series of daily air temperature and daily temperature range (1991 1998) as well as a 4-year time series of the daily atmospheric pressure (1994 1997) and daily pressure range were used. Harmonic models (HM) consisting of annual and lunar cycle harmonic components explained most (R2 > 0.80) of the mean daily species landings and temperature variations, while a rather low part of the variation (0.18 0.6) to the daily fluctuations of the climatic variables at seasonal, mid and short-term scales.

  1. Ecological aspects of the radiation-migration equivalence principle in a closed fuel cycle and its comparative assessment with the ALARA principle

    International Nuclear Information System (INIS)

    Poluektov, P.P.; Lopatkin, A.V.; Nikipelov, B.V.; Rachkov, V.I.; Sukhanov, L.P.; Voloshin, S.V.

    2005-01-01

    The errors and uncertainties arising in the determination of radionuclide escape from the RW burial require the use of extremely conservative estimates. In the limit, the nuclide concentrations in the waste may be used as estimates of their concentrations in underground waters. On this basis, it is possible to evaluate the corresponding radio-toxicities (by normalizing to the interference levels) of individual components and radioactive waste as a whole or the effective radio-toxicities (by dividing the radionuclide radio-toxicities into the retardation factors for the nuclide transfer with underground waters). This completely coincides with the procedure of performing the limiting conservative estimate according to the traditional approach with the use of scenarios, escape models, and the corresponding codes. A comparison of radio-toxicities for waste with those for natural uranium consumed for producing a required fuel results in the notion of radiation-migration equivalence for individual waste components and radioactive waste as a whole. Therefore, the radiation-migration equivalence corresponds to the limiting conservative estimate in the traditional approach to the determination of RW disposal safety in comparison with the radiotoxicity of natural uranium. The amounts of radionuclides in fragments (and actinides) and the corresponding weight of heavy metal in the fuel are compared with due regard for the hazard (according to the NRB-99 standards), the nuclide mobility (through the sorption retardation factors), the retention of radioactive waste by the solid matrix, and the contribution from the chains of uranium fission products. It was noted above that the RME principle is aimed at ensuring the radiological safety of the present and future generations and the environment through the minimization of radioactive waste upon reprocessing. This is attended by reaching a reasonably achievable, low level of radiological action in the context of modern science, i

  2. Application of a high-repetition-rate laser diagnostic system for single-cycle-resolved imaging in internal combustion engines.

    Science.gov (United States)

    Hult, Johan; Richter, Mattias; Nygren, Jenny; Aldén, Marcus; Hultqvist, Anders; Christensen, Magnus; Johansson, Bengt

    2002-08-20

    High-repetition-rate laser-induced fluorescence measurements of fuel and OH concentrations in internal combustion engines are demonstrated. Series of as many as eight fluorescence images, with a temporal resolution ranging from 10 micros to 1 ms, are acquired within one engine cycle. A multiple-laser system in combination with a multiple-CCD camera is used for cycle-resolved imaging in spark-ignition, direct-injection stratified-charge, and homogeneous-charge compression-ignition engines. The recorded data reveal unique information on cycle-to-cycle variations in fuel transport and combustion. Moreover, the imaging system in combination with a scanning mirror is used to perform instantaneous three-dimensional fuel-concentration measurements.

  3. Tidal Influence on the Diel Vertical Migration Pattern of Zooplankton in a Tropical Monsoonal Estuary

    KAUST Repository

    Vineetha, G.; Jyothibabu, R.; Madhu, N. V.; Kusum, K. K.; Sooria, P. M.; Shivaprasad, A.; Reny, P. D.; Deepak, M. P.

    2015-01-01

    in the tidal cycles, which differed from the general concepts of downward migration during ebb tide and upward migration during flood tide in estuarine systems. The weak currents during the slack period might have favored the effective vertical migration

  4. Migrating Worker

    DEFF Research Database (Denmark)

    Hansen, Hans

    This is the preliminary report on the results obtained in the Migrating Worker-project. This project was initiated by the Danish Ministry of Finance with the aim of illustrating the effects of the 1408/71 agreement and the bilateral double taxation agreements Denmark has with the countries included...

  5. Dateline Migration.

    Science.gov (United States)

    Tomasi, Lydio E., Ed.

    1995-01-01

    Presents data on international migration and its effects in and between various countries in North America, Europe, and Africa. Discussions include refugee, immigrant, and migrant worker flows; the legal, political, and social problems surrounding immigrants; alien terrorism and law enforcement problems; and migrant effects on education, social…

  6. Single-cell characterization of in vitro migration and interaction dynamics of T cells expanded with IL-2 and IL-7

    Directory of Open Access Journals (Sweden)

    Johanna Maria Tauriainen

    2015-04-01

    Full Text Available T cells are pivotal in the immune defense against cancers and infectious agents. To mount an effector response against cancer cells, T cells need to migrate to the cancer-site, engage in contacts with cancer cells and perform their effector functions. Adoptive T cell therapy is an effective strategy as treatment of complications such as relapse or opportunistic infections after hematopoietic stem cell transplantations. This requires a sufficient amount of cells that are able to expand and respond to tumor or viral antigens. The cytokines interleukin (IL-2 and IL-7 drive T cell differentiation, proliferation and survival and are commonly used to expand T cells ex vivo. Here, we have used microchip-based live-cell imaging to follow the migration of individual T cells, their interactions with allogeneic monocytes, cell division and apoptosis for extended periods of time; something that cannot be achieved by commonly used methods. Our data indicate that cells grown in IL-7 + IL-2 had similar migration and contact dynamics as cells grown in IL-2 alone. However, the addition of IL-7 decreased cell death creating a more viable cell population, which should be beneficial when preparing cells for immunotherapy.

  7. Lithium-Ion Cell Fault Detection by Single-Point Impedance Diagnostic and Degradation Mechanism Validation for Series-Wired Batteries Cycled at 0 °C

    Directory of Open Access Journals (Sweden)

    Corey T. Love

    2018-04-01

    Full Text Available The utility of a single-point impedance-based technique to monitor the state-of-health of a pack of four 18650 lithium-ion cells wired in series (4S was demonstrated in a previous publication. This work broadens the applicability of the single-point monitoring technique to identify temperature induced faults within 4S packs at 0 °C by two distinct discharge cut-off thresholds: individual cell cut-off and pack voltage cut-off. The results show how the single-point technique applied to a 4S pack can identify cell faults induced by low temperature degradation when plotted on a unique state-of-health map. Cell degradation is validated through an extensive incremental capacity technique to quantify capacity loss due to low temperature cycling and investigate the underpinnings of cell failure.

  8. Cytotoxicity and cell-cycle effects of paclitaxel when used as a single agent and in combination with ionizing radiation

    International Nuclear Information System (INIS)

    Gupta, Nalin; Hu, Lily J.; Deen, Dennis F.

    1997-01-01

    Purpose: This study aimed to determine the extent of paclitaxel-induced cytotoxicity and cell-cycle perturbations when used alone and in combination with radiation in human glioma cells. Methods and Materials: The effect of paclitaxel alone on three human glioma cells lines--SF-126, U-87 MG, and U-251 MG--was assessed after 24, 48, 72, or 96 h treatment. For experiments in combination with radiation, cells were exposed to either a long (48-h) or short (8-h) duration of paclitaxel treatment prior to irradiation. Cell survival was determined by clonogenic assay. Cell cycle perturbations were assessed by using flow cytometry to measure the proportion of cells in G 1 , S, and G 2 /M phases. Results: When cells were treated with paclitaxel alone for ≥24 h, cytotoxicity increased up to a threshold dose, after which it plateaued. When treatment duration was ≤24 h, cytotoxicity was appreciably greater in U-251 MG cells than in SF-126 and U-87 MG cells. After 24 h of paclitaxel treatment, cells in plateau phase growth had increased survival compared to cells in log phase growth. In contrast, after 8 h paclitaxel treatment, mitotic cells had reduced survival compared to cells from an asynchronous population. Cell-cycle perturbations were consistent with the presence of a mitotic block after paclitaxel treatment, although changes in other cell-cycle phase fractions varied among cell lines. For experiments in combination with radiation, cytotoxicity was increased when cells were irradiated after 48 h of paclitaxel treatment but not after 8 h of treatment. Conclusion: The duration of paclitaxel treatment and the location of cells in the cell cycle modify the degree of radiation cytotoxicity. The mechanisms of paclitaxel cytotoxicity are likely to be multifactorial because varying effects are seen in different cell lines. Furthermore, it is clear that simply increasing the number of cells in G 2 /M is insufficient in itself to increase the response of cells to radiation

  9. Single-cell vs. bulk activity properties of coastal bacterioplankton over an annual cycle in a temperate ecosystem.

    Science.gov (United States)

    Morán, Xosé Anxelu G; Calvo-Díaz, Alejandra

    2009-01-01

    The connections between single-cell activity properties of heterotrophic planktonic bacteria and whole community metabolism are still poorly understood. Here, we show flow cytometry single-cell analysis of membrane-intact (live), high nucleic acid (HNA) content and actively respiring (CTC+) bacteria with samples collected monthly during 2006 in northern Spain coastal waters. Bulk activity was assessed by measuring 3H-Leucine incorporation and specific growth rates. Consistently, different single-cell relative abundances were found, with 60-100% for live, 30-84% for HNA and 0.2-12% for CTC+ cells. Leucine incorporation rates (2-153 pmol L(-1) h(-1)), specific growth rates (0.01-0.29 day(-1)) and the total and relative abundances of the three single-cell groups showed marked seasonal patterns. Distinct depth distributions during summer stratification and different relations with temperature, chlorophyll and bacterial biovolume suggest the existence of different controlling factors on each single-cell property. Pooled leucine incorporation rates were similarly correlated with the abundance of all physiological groups, while specific growth rates were only substantially explained by the percentage of CTC+ cells. However, the ability to reduce CTC proved notably better than the other two single-cell properties at predicting bacterial bulk rates within seasons, suggesting a tight linkage between bacterial individual respiration and biomass production at the community level.

  10. A preference for migration

    OpenAIRE

    Stark, Oded

    2007-01-01

    At least to some extent migration behavior is the outcome of a preference for migration. The pattern of migration as an outcome of a preference for migration depends on two key factors: imitation technology and migration feasibility. We show that these factors jointly determine the outcome of a preference for migration and we provide examples that illustrate how the prevalence and transmission of a migration-forming preference yield distinct migration patterns. In particular, the imitation of...

  11. A σ-T diagram analysis regarding the γ' inhibition in β ↔ β' + γ' cycling in CuAlNi single crystals

    International Nuclear Information System (INIS)

    Gastien, R.; Corbellani, C.E.; Sade, M.; Lovey, F.C.

    2006-01-01

    An effect of inhibition of the γ' martensitic structure in thermal and pseudoelastic β ↔ β' + γ' cycling in CuAlNi single crystals was reported previously [Gastien R, Corbellani CE, Alvarez Villar HN, Sade M, Lovey FC. Mater Sci Eng A 2003;349:191], and an experiment to determine the new thermodynamic parameters to obtain the stress-induced γ' structure was performed [Gastien R, Corbellani CE, Sade M, Lovey FC. Acta Mater 2005;53:1685]. In this paper, a thermodynamic analysis of this effect using σ-T diagrams is proposed, in order to obtain a proper estimation of the energy involved in the inhibition process for pseudoelastic β ↔ β' + γ' cycling

  12. Water and contaminant movement: migration barriers

    International Nuclear Information System (INIS)

    Lane, L.J.; Nyhan, J.W.

    1984-11-01

    Migration barriers are used in shallow land burial facilities to slow or stop the movement of water and contaminants and are discussed here as a single component embedded in a complex environmental system. Analytical solutions to solute transport equations are used to approximate the behavior of migration barriers and to derive design criteria for control of subsurface water and contaminant migration. Various types of migration barriers are compared and design recommendations are made for shallow land burial trench caps and liners. Needed improvements and suggested field experiments for future designs of migration barriers are then discussed relative to the management of low-level radioactive wastes

  13. Studies of an extensively axisymmetric rocket based combined cycle (RBCC) engine powered single-stage-to-orbit (SSTO) vehicle

    Science.gov (United States)

    Foster, Richard W.; Escher, William J. D.; Robinson, John W.

    1989-01-01

    The present comparative performance study has established that rocket-based combined cycle (RBCC) propulsion systems, when incorporated by essentially axisymmetric SSTO launch vehicle configurations whose conical forebody maximizes both capture-area ratio and total capture area, are capable of furnishing payload-delivery capabilities superior to those of most multistage, all-rocket launchers. Airbreathing thrust augmentation in the rocket-ejector mode of an RBCC powerplant is noted to make a major contribution to final payload capability, by comparison to nonair-augmented rocket engine propulsion systems.

  14. Computer code for single-point thermodynamic analysis of hydrogen/oxygen expander-cycle rocket engines

    Science.gov (United States)

    Glassman, Arthur J.; Jones, Scott M.

    1991-01-01

    This analysis and this computer code apply to full, split, and dual expander cycles. Heat regeneration from the turbine exhaust to the pump exhaust is allowed. The combustion process is modeled as one of chemical equilibrium in an infinite-area or a finite-area combustor. Gas composition in the nozzle may be either equilibrium or frozen during expansion. This report, which serves as a users guide for the computer code, describes the system, the analysis methodology, and the program input and output. Sample calculations are included to show effects of key variables such as nozzle area ratio and oxidizer-to-fuel mass ratio.

  15. Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus

    DEFF Research Database (Denmark)

    Russell, Rodney S; Meunier, Jean-Christophe; Takikawa, Shingo

    2008-01-01

    mutations that were selected during serial passage in Huh-7.5 cells were studied. Recombinant genomes containing all five mutations produced 3-4 logs more infectious virions than did wild type. Neither a coding mutation in NS5A nor a silent mutation in E2 was adaptive, whereas coding mutations in E2, p7......The JFH1 strain of hepatitis C virus (HCV) is unique among HCV isolates, in that the wild-type virus can traverse the entire replication cycle in cultured cells. However, without adaptive mutations, only low levels of infectious virus are produced. In the present study, the effects of five...

  16. Single-cycle immunodeficiency viruses provide strategies for uncoupling in vivo expression levels from viral replicative capacity and for mimicking live-attenuated SIV vaccines

    International Nuclear Information System (INIS)

    Kuate, Seraphin; Stahl-Hennig, Christiane; Haaft, Peter ten; Heeney, Jonathan; Ueberla, Klaus

    2003-01-01

    To reduce the risks associated with live-attenuated immunodeficiency virus vaccines, single-cycle immunodeficiency viruses (SCIVs) were developed by primer complementation and production of the vaccine in the absence of vif in a vif-independent cell line. After a single intravenous injection of SCIVs into rhesus monkeys, peak viral RNA levels of 10 3 to 10 4 copies/ml plasma were observed, indicating efficient expression of SCIV in the vaccinee. After booster immunizations with SCIVs, SIV-specific humoral and cellular immune responses were observed. Although the vaccine doses used in this pilot study could not protect vaccinees from subsequent intravenous challenge with pathogenic SIVmac239, our results demonstrate that the novel SCIV approach allows us to uncouple in vivo expression levels from the viral replicative capacity facilitating the analysis of the relationship between viral expression levels or viral genes and immune responses induced by SIV

  17. Vulnerable to HIV / AIDS. Migration.

    Science.gov (United States)

    Fernandez, I

    1998-01-01

    This special report discusses the impact of globalization, patterns of migration in Southeast Asia, gender issues in migration, the links between migration and HIV/AIDS, and spatial mobility and social networks. Migrants are particularly marginalized in countries that blame migrants for transmission of infectious and communicable diseases and other social ills. Effective control of HIV/AIDS among migrant and native populations requires a multisectoral approach. Programs should critically review the privatization of health care services and challenge economic models that polarize the rich and the poor, men and women, North and South, and migrant and native. Programs should recognize the equality between locals and migrants in receipt of health services. Countermeasures should have input from migrants in order to reduce the conditions that increase vulnerability to HIV/AIDS. Gender-oriented research is needed to understand women's role in migration. Rapid assessment has obscured the human dimension of migrants' vulnerability to HIV. Condom promotion is not enough. Migration is a major consequence of globalization, which holds the promise, real or imagined, of prosperity for all. Mass migration can be fueled by explosive regional developments. In Southeast Asia, migration has been part of the process of economic development. The potential to emigrate increases with greater per capita income. "Tiger" economies have been labor importers. Safe sex is not practiced in many Asian countries because risk is not taken seriously. Migrants tend to be used as economic tools, without consideration of social adjustment and sex behavior among singles.

  18. HiHiMap: single-cell quantitation of histones and histone posttranslational modifications across the cell cycle by high-throughput imaging.

    Science.gov (United States)

    Zane, Linda; Chapus, Fleur; Pegoraro, Gianluca; Misteli, Tom

    2017-08-15

    We describe Hi gh-throughput Hi stone Map ping (HiHiMap), a high-throughput imaging method to measure histones and histone posttranslational modifications (PTMs) in single cells. HiHiMap uses imaging-based quantification of DNA and cyclin A to stage individual cells in the cell cycle to determine the levels of histones or histone PTMs in each stage of the cell cycle. As proof of principle, we apply HiHiMap to measure the level of 21 core histones, histone variants, and PTMs in primary, immortalized, and transformed cells. We identify several histone modifications associated with oncogenic transformation. HiHiMap allows the rapid, high-throughput study of histones and histone PTMs across the cell cycle and the study of subpopulations of cells. © 2017 Zane et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  19. Generation of single attosecond pulse within one atomic unit by using multi-cycle inhomogeneous polarization gating technology in bowtie-shaped nanostructure

    Science.gov (United States)

    Feng, Liqiang; Liu, Hang

    2018-04-01

    The generations of high-order harmonic spectra and single attosecond pulses (SAPs) driven by the multi-cycle inhomogeneous polarization gating (PG) technology in the bowtie-shaped nanostructure have been theoretically investigated. It is found that by setting the bowtie-shaped nanostructure along the driven laser polarization direction, not only the extension of the harmonic cutoff can be achieved, caused by the surface plasmon polaritons, but also the modulations of the harmonics can be decreased, caused by the PG technology and the inhomogeneous effect. As a result, the contribution of the harmonic plateau is only from one harmonic emission peak with the dominant short quantum path. Further, by properly adding a half-cycle pulse into the driven laser field, the harmonic emission process can be precisely controlled in the half-cycle duration and a supercontinuum with the bandwidth of 263 eV can be obtained. Finally, by directly superposing the harmonics from this supercontinuum, a SAP with the full width at half maximum of 23 as can be obtained, which is shorter than one atomic unit.

  20. Rural migration in southern Nevada

    International Nuclear Information System (INIS)

    Mosser, D.; Soden, D.L.

    1993-01-01

    This study reviews the history of migration in two rural counties in Southern Nevada. It is part of a larger study about the impact of a proposed high-level nuclear waste repository on, in and out-migration patterns in the state. The historical record suggests a boom and bust economic cycle has predominated in the region for the past century creating conditions that should be taken into account, by decision makers, when ascertaining the long-term impacts of the proposed repository

  1. Plasticity of Cell Migration In Vivo and In Silico

    NARCIS (Netherlands)

    Boekhorst, V. Te; Preziosi, L.; Friedl, P.

    2016-01-01

    Cell migration results from stepwise mechanical and chemical interactions between cells and their extracellular environment. Mechanistic principles that determine single-cell and collective migration modes and their interconversions depend upon the polarization, adhesion, deformability,

  2. Effects of single dose GnRH agonist as luteal support on pregnancy outcome in frozen-thawed embryo transfer cycles: an RCT

    Directory of Open Access Journals (Sweden)

    Robab Davar

    2015-08-01

    Full Text Available Background: There is no doubt that luteal phase support is essential to enhance the reproductive outcome in IVF cycles. In addition to progesterone and human chorionic gonadotropin, several studies have described GnRH agonists as luteal phase support to improve implantation rate, pregnancy rate and live birth rate, whereas other studies showed dissimilar conclusions. All of these studies have been done in fresh IVF cycles. Objective: To determine whether an additional GnRH agonist administered at the time of implantation for luteal phase support in frozen-thawed embryo transfer (FET improves the embryo developmental potential. Materials and Methods: This is a prospective controlled trial study in 200 FET cycles, patients were randomized on the day of embryo transfer into group 1 (n=100 to whom a single dose of GnRH agonist (0.1 mg triptorelin was administered three days after transfer and group 2 (n=100, who did not receive agonist. Both groups received daily vaginal progesterone suppositories plus estradiol valerate 6 mg daily. Primary outcome measure was clinical pregnancy rate. Secondary outcome measures were implantation rate, chemical, ongoing pregnancy rate and abortion rate. Results: A total of 200 FET cycles were analyzed. Demographic data and embryo quality were comparable between two groups. No statistically significant difference in clinical and ongoing pregnancy rates was observed between the two groups (26% versus 21%, p=0.40 and 21% versus 17%, p=0.37, respectively. Conclusion: Administration of a subcutaneous GnRH agonist at the time of implantation does not increase clinical or ongoing pregnancy.

  3. Systems Level Dissection of Anaerobic Methane Cycling: Quantitative Measurements of Single Cell Ecophysiology, Genetic Mechanisms, and Microbial Interactions

    Energy Technology Data Exchange (ETDEWEB)

    Orphan, Victoria [California Inst. of Technology (CalTech), Pasadena, CA (United States); Tyson, Gene [University of Queensland, Brisbane Australia; Meile, Christof [University of Georgia, Athens, Georgia; McGlynn, Shawn [California Inst. of Technology (CalTech), Pasadena, CA (United States); Yu, Hang [California Inst. of Technology (CalTech), Pasadena, CA (United States); Chadwick, Grayson [California Inst. of Technology (CalTech), Pasadena, CA (United States); Marlow, Jeffrey [California Inst. of Technology (CalTech), Pasadena, CA (United States); Trembath-Reichert, Elizabeth [California Inst. of Technology (CalTech), Pasadena, CA (United States); Dekas, Anne [California Inst. of Technology (CalTech), Pasadena, CA (United States); Hettich, Robert [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Pan, Chongle [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ellisman, Mark [University of California San Diego; Hatzenpichler, Roland [California Inst. of Technology (CalTech), Pasadena, CA (United States); Skennerton, Connor [California Inst. of Technology (CalTech), Pasadena, CA (United States); Scheller, Silvan [California Inst. of Technology (CalTech), Pasadena, CA (United States)

    2017-12-25

    The global biological CH4 cycle is largely controlled through coordinated and often intimate microbial interactions between archaea and bacteria, the majority of which are still unknown or have been only cursorily identified. Members of the methanotrophic archaea, aka ‘ANME’, are believed to play a major role in the cycling of methane in anoxic environments coupled to sulfate, nitrate, and possibly iron and manganese oxides, frequently forming diverse physical and metabolic partnerships with a range of bacteria. The thermodynamic challenges overcome by the ANME and their bacterial partners and corresponding slow rates of growth are common characteristics in anaerobic ecosystems, and, in stark contrast to most cultured microorganisms, this type of energy and resource limited microbial lifestyle is likely the norm in the environment. While we have gained an in-depth systems level understanding of fast-growing, energy-replete microorganisms, comparatively little is known about the dynamics of cell respiration, growth, protein turnover, gene expression, and energy storage in the slow-growing microbial majority. These fundamental properties, combined with the observed metabolic and symbiotic versatility of methanotrophic ANME, make these cooperative microbial systems a relevant (albeit challenging) system to study and for which to develop and optimize culture-independent methodologies, which enable a systems-level understanding of microbial interactions and metabolic networks. We used an integrative systems biology approach to study anaerobic sediment microcosms and methane-oxidizing bioreactors and expanded our understanding of the methanotrophic ANME archaea, their interactions with physically-associated bacteria, ecophysiological characteristics, and underlying genetic basis for cooperative microbial methane-oxidation linked with different terminal electron acceptors. Our approach is inherently multi-disciplinary and multi-scaled, combining transcriptional and

  4. Promoter binding, initiation, and elongation by bacteriophage T7 RNA polymerase. A single-molecule view of the transcription cycle.

    Science.gov (United States)

    Skinner, Gary M; Baumann, Christoph G; Quinn, Diana M; Molloy, Justin E; Hoggett, James G

    2004-01-30

    A single-molecule transcription assay has been developed that allows, for the first time, the direct observation of promoter binding, initiation, and elongation by a single RNA polymerase (RNAP) molecule in real-time. To promote DNA binding and transcription initiation, a DNA molecule tethered between two optically trapped beads was held near a third immobile surface bead sparsely coated with RNAP. By driving the optical trap holding the upstream bead with a triangular oscillation while measuring the position of both trapped beads, we observed the onset of promoter binding, promoter escape (productive initiation), and processive elongation by individual RNAP molecules. After DNA template release, transcription re-initiation on the same DNA template is possible; thus, multiple enzymatic turnovers by an individual RNAP molecule can be observed. Using bacteriophage T7 RNAP, a commonly used RNAP paradigm, we observed the association and dissociation (k(off)= 2.9 s(-1)) of T7 RNAP and promoter DNA, the transition to the elongation mode (k(for) = 0.36 s(-1)), and the processive synthesis (k(pol) = 43 nt s(-1)) and release of a gene-length RNA transcript ( approximately 1200 nt). The transition from initiation to elongation is much longer than the mean lifetime of the binary T7 RNAP-promoter DNA complex (k(off) > k(for)), identifying a rate-limiting step between promoter DNA binding and promoter escape.

  5. Multispecies breath analysis faster than a single respiratory cycle by optical-feedback cavity-enhanced absorption spectroscopy

    Science.gov (United States)

    Ventrillard-Courtillot, Irene; Gonthiez, Thierry; Clerici, Christine; Romanini, Daniel

    2009-11-01

    We demonstrate a first application, of optical-feedback cavity-enhanced absorption spectroscopy (OF-CEAS) to breath analysis in a medical environment. Noninvasive monitoring of trace species in exhaled air was performed simultaneous to spirometric measurements on patients at Bichat Hospital (Paris). The high selectivity of the OF-CEAS spectrometer and a time response of 0.3 s (limited by sample flow rate) allowed following the evolution of carbon monoxide and methane concentrations during individual respiratory cycles, and resolving variations among different ventilatory patterns. The minimum detectable absorption on this time scale is about 3×10-10 cm-1. At the working wavelength of the instrument (2.326 μm), this translates to concentration detection limits of ~1 ppbv (45 picomolar, or ~1.25 μg/m3) for CO and 25 ppbv for CH4, well below concentration values found in exhaled air. This same instrument is also able to provide measurement of NH3 concentrations with a detection limit of ~10 ppbv however, at present, memory effects do not allow its measurement on fast time scales.

  6. Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells.

    Science.gov (United States)

    Tsang, Jason C H; Yu, Yong; Burke, Shannon; Buettner, Florian; Wang, Cui; Kolodziejczyk, Aleksandra A; Teichmann, Sarah A; Lu, Liming; Liu, Pentao

    2015-09-21

    Hematopoietic stem cells (HSCs) are a rare cell type with the ability of long-term self-renewal and multipotency to reconstitute all blood lineages. HSCs are typically purified from the bone marrow using cell surface markers. Recent studies have identified significant cellular heterogeneities in the HSC compartment with subsets of HSCs displaying lineage bias. We previously discovered that the transcription factor Bcl11a has critical functions in the lymphoid development of the HSC compartment. In this report, we employ single-cell transcriptomic analysis to dissect the molecular heterogeneities in HSCs. We profile the transcriptomes of 180 highly purified HSCs (Bcl11a (+/+) and Bcl11a (-/-)). Detailed analysis of the RNA-seq data identifies cell cycle activity as the major source of transcriptomic variation in the HSC compartment, which allows reconstruction of HSC cell cycle progression in silico. Single-cell RNA-seq profiling of Bcl11a (-/-) HSCs reveals abnormal proliferative phenotypes. Analysis of lineage gene expression suggests that the Bcl11a (-/-) HSCs are constituted of two distinct myeloerythroid-restricted subpopulations. Remarkably, similar myeloid-restricted cells could also be detected in the wild-type HSC compartment, suggesting selective elimination of lymphoid-competent HSCs after Bcl11a deletion. These defects are experimentally validated in serial transplantation experiments where Bcl11a (-/-) HSCs are myeloerythroid-restricted and defective in self-renewal. Our study demonstrates the power of single-cell transcriptomics in dissecting cellular process and lineage heterogeneities in stem cell compartments, and further reveals the molecular and cellular defects in the Bcl11a-deficient HSC compartment.

  7. Hormonal, Metabolic and Cardiorespiratory Responses of Young and Adult Athletes to a Single Session of High Intensity Cycle Exercise

    OpenAIRE

    Engel, Florian; Härtel, Sascha; Wagner, Matthias Oliver; Strahler, Jana; Bös, Klaus; Sperlich, Billy

    2014-01-01

    This study aimed to determine the effects of a single High Intensity Interval Training (HIIT) session on salivary cortisol (SC) levels, physiological responses and performance in trained boys and men. Twenty-three boys (11.5±0.8 years) and 25 men (29.7±4.6 years) performed HIIT (four consecutive Wingate Anaerobic Tests). SC in boys and men increased after HIIT from 5.55±3.3 nmol/l to 15.13±9.7 nmol/l (+173%) and from 7.07±4.7 nmol/l to 19.19±12.7 nmol/l (+171%), respectively (p

  8. Migration and clinical outcome of mobile-bearing versus fixed-bearing single-radius total knee arthroplasty : A randomized controlled trial

    NARCIS (Netherlands)

    Van Hamersveld, Koen T.; Marang-Van De Mheen, Perla J.; Van Der Heide, Huub J.L.; Van Der Linden-Van Der Zwaag, Henrica M.J.; Valstar, E.R.; Nelissen, R.G.H.H.

    2018-01-01

    Background and purpose — Mobile-bearing total knee prostheses (TKPs) were developed in the 1970s in an attempt to increase function and improve implant longevity. However, modern fixed-bearing designs like the single-radius TKP may provide similar advantages. We compared tibial component

  9. A comparison of single-suture and double-suture incision closures in seaward-migrating juvenile Chinook salmon implanted with acoustic transmitters: implications for research in river basins containing hydropower structures

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Richard S.; Deters, Katherine A.; Cook, Katrina V.; Eppard, M. B.

    2013-07-15

    Reductions in the size of acoustic transmitters implanted in migrating juvenile salmonids have resulted in the ability to make shorter incisions that may warrant using only a single suture for closure. However, it is not known if one suture will sufficiently hold the incision closed, particularly when outward pressure is placed on the surgical site such as when migrating fish experience pressure changes associated with passage at hydroelectric dams. The objective of this research was to evaluate the effectiveness of single-suture incision closures on juvenile Chinook salmon (Oncorhynchus tshawytscha). Juvenile Chinook salmon were surgically implanted with a 2012 Juvenile Salmon Acoustic Telemetry System (JSATS) transmitter (0.30 g) and a passive integrated transponder tag (0.10 g) and incisions were closed with either one suture or two sutures. Mortality and tag retention were monitored and fish were examined after 7 and 14 days to evaluate tissue responses. In a separate experiment, surgically implanted fish were exposed to simulated turbine passage and then examined for expulsion of transmitters, expulsion of viscera through the incision, and mortal injury. With incisions closed using a single suture, there was no mortality or tag loss and similar or reduced tissue reaction compared to incisions closed with two sutures. Further, surgery time was significantly reduced when one suture was used, which leads to less handling and reduced stress. No tags were expelled during pressure scenarios and expulsion of viscera only occurred in two non-mortally injured fish (5%) with single sutures that were also exposed to very high pressure changes. No viscera expulsion was present in fish exposed to pressure scenarios likely representative of hydroturbine passage at many Columbia River dams (e.g. <2.7 ratio of pressure change; an acclimation pressure of 146.2 absolute kpa and a lowest exposure pressure of ~ 53.3 absolute kpa). Based on these results, we recommend the use of a

  10. Single and Combined Effects of Beetroot Crystals and Sodium Bicarbonate on 4-km Cycling Time Trial Performance.

    Science.gov (United States)

    Callahan, Marcus J; Parr, Evelyn B; Hawley, John A; Burke, Louise M

    2017-06-01

    When ingested alone, beetroot juice and sodium bicarbonate are ergogenic for high-intensity exercise performance. This study sought to determine the independent and combined effects of these supplements. Eight endurance trained (VO 2 max 65 mL·kg·min -1 ) male cyclists completed four × 4-km time trials (TT) in a doubleblind Latin square design supplementing with beetroot crystals (BC) for 3 days (15 g·day -1 + 15 g 1 h before TT, containing 300 mg nitrate per 15 g), bicarbonate (Bi 0.3 g·kg -1 body mass [BM] in 5 doses every 15 min from 2.5 h before TT); BC+Bi or placebo (PLA). Subjects completed TTs on a Velotron cycle ergometer under standardized laboratory conditions. Plasma nitrite concentrations were significantly elevated only in the BC+Bi trial before the TT (1520 ± 786 nmol·L -1 ) compared with baseline (665 ± 535 nmol·L -1 , p = .02) and the Bi and PLA conditions (Bi: 593 ± 203 nmol·L -1 , p .05). Blood bicarbonate concentrations were increased in the BC+Bi and Bi trials before the TT (BC+Bi: 30.9 ± 2.8 mmol·L -1 ; Bi: 31.7 ± 1.1 mmol·L -1 ). There were no differences in mean power output (386-394 W) or the time taken to complete the TT (335.8-338.1 s) between any conditions. Under the conditions of this study, supplementation was not ergogenic for 4-km TT performance.

  11. A randomized assessor-blind trial comparing highly purified hMG and recombinant FSH in a GnRH antagonist cycle with compulsory single-blastocyst transfer

    DEFF Research Database (Denmark)

    Devroey, Paul; Pellicer, Antonio; Nyboe Andersen, Anders

    2012-01-01

    MG versus 27% with rFSH for the per-protocol (PP) population and 29% versus 27% for the intention-to-treat (ITT) population. Noninferiority of hphMG compared to rFSH was established. Considering frozen cycles initiated within 1 year, the cumulative live birth rate for a single stimulation cycle was 40...... blastocyst replacement in natural cycles initiated within 1 year of each patient's start of treatment. MAIN OUTCOME MEASURE(S): Ongoing pregnancy (primary end point) and live birth rates, as well as pharmacodynamic parameters. RESULT(S): The ongoing pregnancy rate after a fresh cycle was 30% with hph...

  12. The Globalisation of migration

    OpenAIRE

    Milan Mesić

    2002-01-01

    The paper demonstrates that contemporary international migration is a constitutive part of the globalisation process. After defining the concepts of globalisation and the globalisation of migration, the author discusses six key themes, linking globalisation and international migration (“global cities”, the scale of migration; diversification of migration flows; globalisation of science and education; international migration and citizenship; emigrant communities and new identities). First, in ...

  13. Extracorporal Shock Waves Activate Migration, Proliferation and Inflammatory Pathways in Fibroblasts and Keratinocytes, and Improve Wound Healing in an Open-Label, Single-Arm Study in Patients with Therapy-Refractory Chronic Leg Ulcers.

    Science.gov (United States)

    Aschermann, Ilknur; Noor, Seema; Venturelli, Sascha; Sinnberg, Tobias; Mnich, Christian D; Busch, Christian

    2017-01-01

    Chronic leg ulcers (CLUs) are globally a major cause of morbidity and mortality with increasing prevalence. Their treatment is highly challenging, and many conservative, surgical or advanced therapies have been suggested, but with little overall efficacy. Since the 1980s extracorporal shock wave therapy (ESWT) has gained interest as treatment for specific indications. Here, we report that patients with CLU showed wound healing after ESWT and investigated the underlying molecular mechanisms. We performed cell proliferation and migration assays, FACS- and Western blot analyses, RT-PCR, and Affymetrix gene expression analyses on human keratinocytes and fibroblasts, and a tube formation assay on human microvascular endothelial cells to assess the impact of shock waves in vitro. In vivo, chronic therapy-refractory leg ulcers were treated with ESWT, and wound healing was assessed. Upon ESWT, we observed morphological changes and increased cell migration of keratinocytes. Cell-cycle regulatory genes were upregulated, and proliferation induced in fibroblasts. This was accompanied by secretion of pro-inflammatory cytokines from keratinocytes, which are known to drive wound healing, and a pro-angiogenic activity of endothelial cells. These observations were transferred "from bench to bedside", and 60 consecutive patients with 75 CLUs with different pathophysiologies (e.g. venous, mixed arterial-venous, arterial) were treated with ESWT. In this setting, 41% of ESWT-treated CLUs showed complete healing, 16% significant improvement, 35% improvement, and 8% of the ulcers did not respond to ESWT. The induction of healing was independent of patient age, duration or size of the ulcer, and the underlying pathophysiology. The efficacy of ESWT needs to be confirmed in controlled trials to implement ESWT as an adjunct to standard therapy or as a stand-alone treatment. Our results suggest that EWST may advance the treatment of chronic, therapy-refractory ulcers. © 2017 The Author

  14. Extracorporal Shock Waves Activate Migration, Proliferation and Inflammatory Pathways in Fibroblasts and Keratinocytes, and Improve Wound Healing in an Open-Label, Single-Arm Study in Patients with Therapy-Refractory Chronic Leg Ulcers

    Directory of Open Access Journals (Sweden)

    Ilknur Aschermann

    2017-02-01

    Full Text Available Background/Aims: Chronic leg ulcers (CLUs are globally a major cause of morbidity and mortality with increasing prevalence. Their treatment is highly challenging, and many conservative, surgical or advanced therapies have been suggested, but with little overall efficacy. Since the 1980s extracorporal shock wave therapy (ESWT has gained interest as treatment for specific indications. Here, we report that patients with CLU showed wound healing after ESWT and investigated the underlying molecular mechanisms. Methods: We performed cell proliferation and migration assays, FACS- and Western blot analyses, RT-PCR, and Affymetrix gene expression analyses on human keratinocytes and fibroblasts, and a tube formation assay on human microvascular endothelial cells to assess the impact of shock waves in vitro. In vivo, chronic therapy-refractory leg ulcers were treated with ESWT, and wound healing was assessed. Results: Upon ESWT, we observed morphological changes and increased cell migration of keratinocytes. Cell-cycle regulatory genes were upregulated, and proliferation induced in fibroblasts. This was accompanied by secretion of pro-inflammatory cytokines from keratinocytes, which are known to drive wound healing, and a pro-angiogenic activity of endothelial cells. These observations were transferred “from bench to bedside”, and 60 consecutive patients with 75 CLUs with different pathophysiologies (e.g. venous, mixed arterial-venous, arterial were treated with ESWT. In this setting, 41% of ESWT-treated CLUs showed complete healing, 16% significant improvement, 35% improvement, and 8% of the ulcers did not respond to ESWT. The induction of healing was independent of patient age, duration or size of the ulcer, and the underlying pathophysiology. Conclusions: The efficacy of ESWT needs to be confirmed in controlled trials to implement ESWT as an adjunct to standard therapy or as a stand-alone treatment. Our results suggest that EWST may advance the

  15. Hormonal, metabolic, and cardiorespiratory responses of young and adult athletes to a single session of high-intensity cycle exercise.

    Science.gov (United States)

    Engel, Florian; Härtel, Sascha; Wagner, Matthias Oliver; Strahler, Jana; Bös, Klaus; Sperlich, Billy

    2014-11-01

    This study aimed to determine the effects of a single high-intensity interval training (HIIT) session on salivary cortisol (SC) levels, physiological responses, and performance in trained boys and men. Twenty-three boys (11.5 ± 0.8 years) and 25 men (29.7 ± 4.6 years) performed HIIT (4 consecutive Wingate Anaerobic Tests). SC in boys and men increased after HIIT from 5.55 ± 3.3 nmol/l to 15.13 ± 9.7 nmol/l (+173%) and from 7.07 ± 4.7 nmol/l to 19.19 ± 12.7 nmol/l (+171%), respectively (p HIIT, mean heart rates in boys were higher (p HIIT in young athletes is associated with a higher activation of the hormonal stress axis than other types of exercise regimes as described in the literature. This study is the first to show a pronounced SC increase to HIIT in trained boys accompanied by elevated levels of blood lactate concentrations and heart rate suggesting a high cardio-respiratory, metabolic, and hormonal response to HIIT in 11-year-old boys.

  16. Scaling submillimeter single-cycle transients toward megavolts per centimeter field strength via optical rectification in the organic crystal OH1.

    Science.gov (United States)

    Ruchert, Clemens; Vicario, Carlo; Hauri, Christoph P

    2012-03-01

    We present the generation of high-power single-cycle terahertz (THz) pulses in the organic salt crystal 2-[3-(4-hydroxystyryl)-5.5-dimethylcyclohex-2-enylidene]malononitrile or OH1. Broadband THz radiation with a central frequency of 1.5 THz (λ(c)=200 μm) and high electric field strength of 440 kV/cm is produced by optical rectification driven by the signal of a powerful femtosecond optical parametric amplifier. A 1.5% pump to THz energy conversion efficiency is reported, and pulse energy stability better than 1% RMS is achieved. An approach toward the realization of higher field strength is discussed. © 2012 Optical Society of America

  17. A Prime-Boost Vaccination Strategy in Cattle to Prevent Foot-and-Mouth Disease Using a "Single-Cycle" Alphavirus Vector and Empty Capsid Particles

    DEFF Research Database (Denmark)

    Gullberg, Maria; Lohse, Louise; Bøtner, Anette

    2016-01-01

    Foot-and-mouth disease (FMD) remains one of the most economically important infectious diseases of production animals globally. Vaccination can successfully control this disease, however, current vaccines are imperfect. They are made using chemically inactivated FMD virus (FMDV) that is produced...... in large-scale mammalian cell culture under high containment conditions. Here, we have expressed the FMDV capsid protein precursor (P1-2A) of strain O1 Manisa alone or with the FMDV 3C protease (3Cpro) using a "single cycle" packaged alphavirus self-replicating RNA based on Semliki Forest virus (SFV). When...... the FMDV P1-2A was expressed with 3Cpro then processing of the FMDV capsid precursor protein is observed within cells and the proteins assemble into empty capsid particles. The products interact with anti-FMDV antibodies in an ELISA and bind to the integrin αvβ6 (a cellular receptor for FMDV). In cattle...

  18. Direct measuring of single-cycle mid-IR light bullets path length in LiF by the laser coloration method

    Directory of Open Access Journals (Sweden)

    Chekalin Sergey

    2017-01-01

    Full Text Available A colour-centre structure formed in a LiF crystal under filamentation of a femtosecond mid-IR laser pulse with a power slightly exceeding the critical power for self-focusing has been experimentally and theoretically investigated. A single-cycle light bullet was recorded for the first time by observation of strictly periodic oscillations for the density of the color centers induced in an isotropic LiF crystal under filamentation of a laser beam with a wavelength tuned in the range from 2600 to 3900 nm, which is due to the periodic change in the light field amplitude in the light bullet formed under filamentation under propagation in dispersive medium. The light bullet path length was not more than one millimeter.

  19. Robust inducible Cre recombinase activity in the human malaria parasite Plasmodium falciparum enables efficient gene deletion within a single asexual erythrocytic growth cycle.

    Science.gov (United States)

    Collins, Christine R; Das, Sujaan; Wong, Eleanor H; Andenmatten, Nicole; Stallmach, Robert; Hackett, Fiona; Herman, Jean-Paul; Müller, Sylke; Meissner, Markus; Blackman, Michael J

    2013-05-01

    Asexual blood stages of the malaria parasite, which cause all the pathology associated with malaria, can readily be genetically modified by homologous recombination, enabling the functional study of parasite genes that are not essential in this part of the life cycle. However, no widely applicable method for conditional mutagenesis of essential asexual blood-stage malarial genes is available, hindering their functional analysis. We report the application of the DiCre conditional recombinase system to Plasmodium falciparum, the causative agent of the most dangerous form of malaria. We show that DiCre can be used to obtain rapid, highly regulated site-specific recombination in P. falciparum, capable of excising loxP-flanked sequences from a genomic locus with close to 100% efficiency within the time-span of a single erythrocytic growth cycle. DiCre-mediated deletion of the SERA5 3' UTR failed to reduce expression of the gene due to the existence of alternative cryptic polyadenylation sites within the modified locus. However, we successfully used the system to recycle the most widely used drug resistance marker for P. falciparum, human dihydrofolate reductase, in the process producing constitutively DiCre-expressing P. falciparum clones that have broad utility for the functional analysis of essential asexual blood-stage parasite genes. © 2013 John Wiley & Sons Ltd.

  20. Energy, Exergy and Economic Evaluation Comparison of Small-Scale Single and Dual Pressure Organic Rankine Cycles Integrated with Low-Grade Heat Sources

    Directory of Open Access Journals (Sweden)

    Armando Fontalvo

    2017-09-01

    Full Text Available Low-grade heat sources such as solar thermal, geothermal, exhaust gases and industrial waste heat are suitable alternatives for power generation which can be exploited by means of small-scale Organic Rankine Cycle (ORC. This paper combines thermodynamic optimization and economic analysis to assess the performance of single and dual pressure ORC operating with different organic fluids and targeting small-scale applications. Maximum power output is lower than 45 KW while the temperature of the heat source varies in the range 100–200 °C. The studied working fluids, namely R1234yf, R1234ze(E and R1234ze(Z, are selected based on environmental, safety and thermal performance criteria. Levelized Cost of Electricity (LCOE and Specific Investment Cost (SIC for two operation conditions are presented: maximum power output and maximum thermal efficiency. Results showed that R1234ze(Z achieves the highest net power output (up to 44 kW when net power output is optimized. Regenerative ORC achieves the highest performance when thermal efficiency is optimized (up to 18%. Simple ORC is the most cost-effective among the studied cycle configurations, requiring a selling price of energy of 0.3 USD/kWh to obtain a payback period of 8 years. According to SIC results, the working fluid R1234ze(Z exhibits great potential for simple ORC when compared to conventional R245fa.

  1. Retrofitted Solar Domestic Hot Water Systems for Swedish Single-Family Houses—Evaluation of a Prototype and Life-Cycle Cost Analysis

    Directory of Open Access Journals (Sweden)

    Luis Ricardo Bernardo

    2016-11-01

    Full Text Available According to recent technology road maps, system cost reductions and development of standardised plug-and-function systems are some of the most important goals for solar heating technology development. Retrofitting hot water boilers in single-family houses when installing solar collectors has the potential to significantly reduce both material and installation costs. Previous studies have investigated such retrofitting, using theoretical simulations and laboratory tests, but no actual installations were made and tested in practice. This article describes the installation, measured performance and cost effectiveness of a retrofitting solution that converts existing domestic hot water heaters to a solar domestic hot water system. The measured performance is characterised by the monthly and annual solar fractions. The cost effectiveness is evaluated by a life-cycle cost analysis, comparing the retrofitted system to a conventional solar domestic hot water system and the case without any solar heating system. Measurements showed that approximately 50% of the 5000 kWh/year of domestic hot water consumption was saved by the retrofitted system in south Sweden. Such savings are in agreement with previous estimations and are comparable to the energy savings when using a conventional solar domestic hot water system. The life-cycle cost analysis showed that, according to the assumptions and given climate, the return on investment of the retrofitted system is approximately 17 years, while a conventional system does not reach profitability during its lifetime of 25 years.

  2. Effects of DNA double-strand and single-strand breaks on intrachromosomal recombination events in cell-cycle-arrested yeast cells

    International Nuclear Information System (INIS)

    Galli, A.; Schiestl, R.H.

    1998-01-01

    Intrachromosomal recombination between repeated elements can result in deletion (DEL recombination) events. We investigated the inducibility of such intrachromosomal recombination events at different stages of the cell cycle and the nature of the primary DNA lesions capable of initiating these events. Two genetic systems were constructed in Saccharomyces cerevisiae that select for DEL recombination events between duplicated alleles of CDC28 and TUB2. We determined effects of double-strand breaks (DSBs) and single-strand breaks (SSBs) between the duplicated alleles on DEL recombination when induced in dividing cells or cells arrested in G1 or G2. Site-specific DSBs and SSBs were produced by overexpression of the I-Sce I endonuclease and the gene II protein (gIIp), respectively. I-Sce I-induced DSBs caused an increase in DEL recombination frequencies in both dividing and cell-cycle-arrested cells, indicating that G1- and G2-arrested cells are capable of completing DSB repair. In contrast, gIIp-induced SSBs caused an increase in DEL recombination frequency only in dividing cells. To further examine these phenomena we used both γ-irradiation, inducing DSBs as its most relevant lesion, and UV, inducing other forms of DNA damage. UV irradiation did not increase DEL recombination frequencies in G1 or G2, whereas γ-rays increased DEL recombination frequencies in both phases. Both forms of radiation, however, induced DEL recombination in dividing cells. The results suggest that DSBsbut not SSBs induce DEL recombination, probably via the single-strand annealing pathway. Further, DSBs in dividing cells may result from the replication of a UV or SSB-damaged template. Alternatively, UV induced events may occur by replication slippage after DNA polymerase pausing in front of the damage. (author)

  3. Migration aspirations and migration cultures : A case study of Ukrainian migration towards the European Union

    NARCIS (Netherlands)

    Van Mol, C.; Snel, Erik; Hemmerechts, Kenneth; Timmerman, Christiane

    2018-01-01

    An abundant body of research focused on macrolevel, mesolevel, and microlevel factors explaining why individuals move across international borders. In this paper, we aim to complement the existing literature by exploring how, within a single country, mesolevel factors differently impact migration

  4. Transgene Expression and Host Cell Responses to Replication-Defective, Single-Cycle, and Replication-Competent Adenovirus Vectors

    Directory of Open Access Journals (Sweden)

    Catherine M. Crosby

    2017-02-01

    Full Text Available Most adenovirus (Ad vectors are E1 gene deleted replication defective (RD-Ad vectors that deliver one transgene to the cell and all expression is based on that one gene. In contrast, E1-intact replication-competent Ad (RC-Ad vectors replicate their DNA and their transgenes up to 10,000-fold, amplifying transgene expression markedly higher than RD-Ad vectors. While RC-Ad are more potent, they run the real risk of causing adenovirus infections in vector recipients and those that administer them. To gain the benefits of transgene amplification, but avoid the risk of Ad infections, we developed “single cycle” Ad (SC-Ad vectors. SC-Ads amplify transgene expression and generated markedly stronger and more persistent immune responses than RD-Ad as expected. However, they also unexpectedly generated stronger immune responses than RC-Ad vectors. To explore the basis of this potency here, we compared gene expression and the cellular responses to infection to these vectors in vitro and in vivo. In vitro, in primary human lung epithelial cells, SC- and RC-Ad amplified their genomes more than 400-fold relative to RD-Ad with higher replication by SC-Ad. This replication translated into higher green fluorescent protein (GFP expression for 48 h by SC- and RC-Ad than by RD-Ad. In vitro, in the absence of an immune system, RD-Ad expression became higher by 72 h coincident with cell death mediated by SC- and RC-Ad and release of transgene product from the dying cells. When the vectors were compared in human THP-1 Lucia- interferon-stimulated gene (ISG cells, which are a human monocyte cell line that have been modified to quantify ISG activity, RC-Ad6 provoked significantly stronger ISG responses than RD- or SC-Ad. In mice, intravenous or intranasal injection produced up to 100-fold genome replication. Under these in vivo conditions in the presence of the immune system, luciferase expression by RC and SC-Ad was markedly higher than that by RD-Ad. In

  5. Cell proliferation and migration in the jejunum of suckling rats submitted to progressive fasting

    Directory of Open Access Journals (Sweden)

    Gomes J.R.

    1998-01-01

    Full Text Available Cell proliferation and migration in the intestinal crypts, and cell migration in the villus are controlled by different mechanisms in adult rats. In the present study, weanling rats and fasting rats were used to quantitatively study the correlation of cell cycle parameters and epithelial cell migration in crypts and intestinal villi. Eighteen-day-old rats received a single injection of tritiated thymidine [3H]TdR (23:00 h; half of the pups were submitted to fasting 5 h earlier. Cell proliferation was determined in radioautographs of jejunal crypts, on the basis of the labeling indices (LI taken 1, 8, 13 and 19 h after [3H]TdR. The results showed that the labeling index did not differ 1 h or 19 h after [3H]TdR between the fed (38.7% or 48% and fasting groups (34.6% or 50.4%. The modified method of grain count halving indicated that cell cycle time did not differ between fed (16.5 h and fasting rats (17.8 h; the growth fraction, however, had lower values in fasting (59% than in fed rats (77%. Cell migration in the crypt, estimated by the LI obtained for each cell position, did not change with treatment. As for the villi, the cell migration rate was significantly retarded by 3 cell positions (8%. These results suggest that the cell migration in the villi of weanling pups does not depend directly on the cell proliferation and migration in the intestinal crypt, but is directly affected by the absence of food in the lumen

  6. Single-Cell Genome and Group-Specific dsrAB Sequencing Implicate Marine Members of the Class Dehalococcoidia (Phylum Chloroflexi) in Sulfur Cycling

    DEFF Research Database (Denmark)

    Wasmund, Kenneth; Cooper, Myriel; Schreiber, Lars

    2016-01-01

    The marine subsurface sediment biosphere is widely inhabited by bacteria affiliated with the class Dehalococcoidia (DEH), phylum Chloroflexi, and yet little is known regarding their metabolisms. In this report, genomic content from a single DEH cell (DEH-C11) with a 16S rRNA gene that was affilia......The marine subsurface sediment biosphere is widely inhabited by bacteria affiliated with the class Dehalococcoidia (DEH), phylum Chloroflexi, and yet little is known regarding their metabolisms. In this report, genomic content from a single DEH cell (DEH-C11) with a 16S rRNA gene...... that was affiliated with a diverse cluster of 16S rRNA gene sequences prevalent in marine sediments was obtained from sediments of Aarhus Bay, Denmark. The distinctive gene content of this cell suggests metabolic characteristics that differ from those of known DEH and Chloroflexi. The presence of genes encoding...... dissimilatory sulfite reductase (Dsr) suggests that DEH could respire oxidized sulfur compounds, although Chloroflexi have never been implicated in this mode of sulfur cycling. Using long-range PCR assays targeting DEH dsr loci, dsrAB genes were amplified and sequenced from various marine sediments. Many...

  7. A vaccinia virus recombinant transcribing an alphavirus replicon and expressing alphavirus structural proteins leads to packaging of alphavirus infectious single cycle particles.

    Directory of Open Access Journals (Sweden)

    Juana M Sánchez-Puig

    Full Text Available Poxviruses and Alphaviruses constitute two promising viral vectors that have been used extensively as expression systems, or as vehicles for vaccine purposes. Poxviruses, like vaccinia virus (VV are well-established vaccine vectors having large insertion capacity, excellent stability, and ease of administration. In turn, replicons derived from Alphaviruses like Semliki Forest virus (SFV are potent protein expression and immunization vectors but stocks are difficult to produce and maintain. In an attempt to demonstrate the use of a Poxvirus as a means for the delivery of small vaccine vectors, we have constructed and characterized VV/SFV hybrid vectors. A SFV replicon cDNA was inserted in the VV genome and placed under the control of a VV early promoter. The replicon, transcribed from the VV genome as an early transcript, was functional, and thus capable of initiating its own replication and transcription. Further, we constructed a VV recombinant additionally expressing the SFV structural proteins under the control of a vaccinia synthetic early/late promoter. Infection with this recombinant produced concurrent transcription of the replicon and expression of SFV structural proteins, and led to the generation of replicon-containing SFV particles that were released to the medium and were able to infect additional cells. This combined VV/SFV system in a single virus allows the use of VV as a SFV delivery vehicle in vivo. The combination of two vectors, and the possibility of generating in vivo single-cycle, replicon containing alphavirus particles, may open new strategies in vaccine development or in the design of oncolytic viruses.

  8. A vaccinia virus recombinant transcribing an alphavirus replicon and expressing alphavirus structural proteins leads to packaging of alphavirus infectious single cycle particles.

    Science.gov (United States)

    Sánchez-Puig, Juana M; Lorenzo, María M; Blasco, Rafael

    2013-01-01

    Poxviruses and Alphaviruses constitute two promising viral vectors that have been used extensively as expression systems, or as vehicles for vaccine purposes. Poxviruses, like vaccinia virus (VV) are well-established vaccine vectors having large insertion capacity, excellent stability, and ease of administration. In turn, replicons derived from Alphaviruses like Semliki Forest virus (SFV) are potent protein expression and immunization vectors but stocks are difficult to produce and maintain. In an attempt to demonstrate the use of a Poxvirus as a means for the delivery of small vaccine vectors, we have constructed and characterized VV/SFV hybrid vectors. A SFV replicon cDNA was inserted in the VV genome and placed under the control of a VV early promoter. The replicon, transcribed from the VV genome as an early transcript, was functional, and thus capable of initiating its own replication and transcription. Further, we constructed a VV recombinant additionally expressing the SFV structural proteins under the control of a vaccinia synthetic early/late promoter. Infection with this recombinant produced concurrent transcription of the replicon and expression of SFV structural proteins, and led to the generation of replicon-containing SFV particles that were released to the medium and were able to infect additional cells. This combined VV/SFV system in a single virus allows the use of VV as a SFV delivery vehicle in vivo. The combination of two vectors, and the possibility of generating in vivo single-cycle, replicon containing alphavirus particles, may open new strategies in vaccine development or in the design of oncolytic viruses.

  9. A Geometry-Based Cycle Slip Detection and Repair Method with Time-Differenced Carrier Phase (TDCP for a Single Frequency Global Position System (GPS + BeiDou Navigation Satellite System (BDS Receiver

    Directory of Open Access Journals (Sweden)

    Chuang Qian

    2016-12-01

    Full Text Available As the field of high-precision applications based on carriers continues to expand, the development of low-cost, small, modular receivers and their application in diverse scenarios and situations with complex data quality has increased the requirements of carrier-phase data preprocessing. A new geometry-based cycle slip detection and repair method based on Global Position System (GPS + BeiDou Navigation Satellite System (BDS is proposed. The method uses a Time-differenced Carrier Phase (TDCP model, which eliminates the Inner-System Bias (ISB between GPS and BDS, and it is conducive to the effective combination of GPS and BDS. It avoids the interference of the noise of the pseudo-range with cycle slip detection, while the cycle slips are preserved as integers. This method does not limit the receiver frequency number, and it is applicable to single-frequency data. The process is divided into two steps to detect and repair cycle slip. The first step is cycle slip detection, using the Improved Local Analysis Method (ILAM to find satellites that have cycle slips; The second step is to repair the cycle slips, including estimating the float solution of changes in ambiguities at the satellites that have cycle slips with the least squares method and the integer solution of the cycle slips by rounding. In the process of rounding, in addition to the success probability, a decimal test is carried out to validate the result. Finally, experiments with filed test data are carried out to prove the effectiveness of this method. The results show that the detectable cycle slips number with GPS + BDS is much greater than that with GPS. The method can also detect the non-integer outliers while fixing the cycle slip. The maximum decimal bias in repair is less than that with GPS. It implies that this method takes full advantages of multi-system.

  10. MANAGING MIGRATION: TURKISH PERSPECTIVE

    Directory of Open Access Journals (Sweden)

    İhsan GÜLAY

    2018-04-01

    Full Text Available Conducting migration studies is of vital importance to Turkey, a country which has been experiencing migration throughout history due to its “open doors policy”. The objective of this study is to evaluate the strategic management of migration in Turkey in order to deal with the issue of migration. The main focus of the study is Syrian migrants who sought refuge in Turkey due to the civil war that broke out in their country in April 2011. This study demonstrates the policies and processes followed by Turkey for Syrian migration flow in terms of the social acceptance and harmonisation of the migrants within a democratic environment. The study addresses some statistical facts and issues related to Syrian migration as it has become an integral part of daily life in Turkey. The study also reviews how human rights are protected in the migration process. The study will provide insights for developing sound strategic management policies for the migration issue.

  11. Migration and revolution

    Directory of Open Access Journals (Sweden)

    Nando Sigona

    2012-06-01

    Full Text Available The Arab Spring has not radically transformed migration patterns in the Mediterranean, and the label ‘migration crisis’ does not do justice to the composite and stratified reality.

  12. Population, migration and urbanization.

    Science.gov (United States)

    1982-06-01

    Despite recent estimates that natural increase is becoming a more important component of urban growth than rural urban transfer (excess of inmigrants over outmigrants), the share of migration in the total population growth has been consistently increasing in both developed and developing countries. From a demographic perspective, the migration process involves 3 elements: an area of origin which the mover leaves and where he or she is considered an outmigrant; the destination or place of inmigration; and the period over which migration is measured. The 2 basic types of migration are internal and international. Internal migration consists of rural to urban migration, urban to urban migration, rural to rural migration, and urban to rural migration. Among these 4 types of migration various patterns or processes are followed. Migration may be direct when the migrant moves directly from the village to the city and stays there permanently. It can be circular migration, meaning that the migrant moves to the city when it is not planting season and returns to the village when he is needed on the farm. In stage migration the migrant makes a series of moves, each to a city closer to the largest or fastest growing city. Temporary migration may be 1 time or cyclical. The most dominant pattern of internal migration is rural urban. The contribution of migration to urbanization is evident. For example, the rapid urbanization and increase in urban growth from 1960-70 in the Republic of Korea can be attributed to net migration. In Asia the largest component of the population movement consists of individuals and groups moving from 1 rural location to another. Recently, because urban centers could no longer absorb the growing number of migrants from other places, there has been increased interest in the urban to rural population redistribution. This reverse migration also has come about due to slower rates of employment growth in the urban centers and improved economic opportunities

  13. [Internal migration studies].

    Science.gov (United States)

    Stpiczynski, T

    1986-10-01

    Recent research on internal migration in Poland is reviewed. The basic sources of data, consisting of censuses or surveys, are first described. The author discusses the relationship between migration studies and other sectors of the national economy, and particularly the relationship between migration and income.

  14. Multicore Considerations for Legacy Flight Software Migration

    Science.gov (United States)

    Vines, Kenneth; Day, Len

    2013-01-01

    In this paper we will discuss potential benefits and pitfalls when considering a migration from an existing single core code base to a multicore processor implementation. The results of this study present options that should be considered before migrating fault managers, device handlers and tasks with time-constrained requirements to a multicore flight software environment. Possible future multicore test bed demonstrations are also discussed.

  15. Migration: The Present State, Problems and Perspectives of Research Paradigms

    Directory of Open Access Journals (Sweden)

    Silva Mežnarić

    2003-12-01

    Full Text Available Two prevailing paradigms in contemporary international migration research – migration as unpredictable explosion and migration as mainly predictable long cycles movement – are put into question. Both paradigms are not valid in explaining latest development in international migration field. They are too robust for reality which is satiated with novel developments in the field of volume, directions, labour markets and structure of migration flows, both voluntary and involuntary. Individual independent migrant as decision maker is coming to the fore. Therefore the reassessment of theoretical and conceptual apparatus of migration is imminent. As to the methods, mathematically supported sociological models of contemporary migration could be needed. On the basis of “new intuition”, the principles of simplicity, parsimony, and universality could lead to a theoretical innovation.

  16. Radon depth migration

    International Nuclear Information System (INIS)

    Hildebrand, S.T.; Carroll, R.J.

    1993-01-01

    A depth migration method is presented that used Radon-transformed common-source seismograms as input. It is shown that the Radon depth migration method can be extended to spatially varying velocity depth models by using asymptotic ray theory (ART) to construct wavefield continuation operators. These operators downward continue an incident receiver-array plane wave and an assumed point-source wavefield into the subsurface. The migration velocity model is constrain to have longer characteristic wavelengths than the dominant source wavelength such that the ART approximations for the continuation operators are valid. This method is used successfully to migrate two synthetic data examples: (1) a point diffractor, and (2) a dipping layer and syncline interface model. It is shown that the Radon migration method has a computational advantage over the standard Kirchhoff migration method in that fewer rays are computed in a main memory implementation

  17. Migration into art

    DEFF Research Database (Denmark)

    Petersen, Anne Ring

    This book addresses a topic of increasing importance to artists, art historians and scholars of cultural studies, migration studies and international relations: migration as a profoundly transforming force that has remodelled artistic and art institutional practices across the world. It explores...... contemporary art's critical engagement with migration and globalisation as a key source for improving our understanding of how these processes transform identities, cultures, institutions and geopolitics. The author explores three interwoven issues of enduring interest: identity and belonging, institutional...

  18. Regional Redistribution and Migration

    DEFF Research Database (Denmark)

    Manasse, Paolo; Schultz, Christian

    We study a model with free migration between a rich and a poor region. Since there is congestion, the rich region has an incentive to give the poor region a transfer in order to reduce immigration. Faced with free migration, the rich region voluntarily chooses a transfer, which turns out...... to be equal to that a social planner would choose. Provided migration occurs in equilibrium, this conclusion holds even in the presence of moderate mobility costs. However, large migration costs will lead to suboptimal transfers in the market solution...

  19. Experience of more than 100 preimplantation genetic diagnosis cycles for monogenetic diseases using whole genome amplification and linkage analysis in a single centre.

    Science.gov (United States)

    Chow, Judy F C; Yeung, William S B; Lee, Vivian C Y; Lau, Estella Y L; Ho, P C; Ng, Ernest H Y

    2015-08-01

    To report the outcomes of more than 100 cycles of preimplantation genetic diagnosis for monogenetic diseases. Case series. Tertiary assisted reproductive centre in Hong Kong, where patients needed to pay for the cost of preimplantation genetic diagnosis on top of standard in-vitro fertilisation charges. Patients undergoing preimplantation genetic diagnosis for monogenetic diseases at the Centre of Assisted Reproduction and Embryology, Queen Mary Hospital-The University of Hong Kong between 1 August 2007 and 30 April 2014 were included. In-vitro fertilisation, intracytoplasmic sperm injection, embryo biopsy, and preimplantation genetic diagnosis. Ongoing pregnancy rate and implantation rate. Overall, 124 cycles of preimplantation genetic diagnosis were initiated in 76 patients, 101 cycles proceeded to preimplantation genetic diagnosis, and 92 cycles had embryo transfer. The ongoing pregnancy rate was 28.2% per initiated cycle and 38.0% per embryo transfer, giving an implantation rate of 35.2%. There were 16 frozen-thawed embryo transfer cycles in which, following preimplantation genetic diagnosis, cryopreserved embryos were replaced resulting in an ongoing pregnancy rate of 37.5% and implantation rate of 30.0%. The cumulative ongoing pregnancy rate was 33.1%. The most frequent indication for preimplantation genetic diagnosis was thalassaemia, followed by neurodegenerative disorder and cancer predisposition. There was no misdiagnosis. Preimplantation genetic diagnosis is a reliable method to prevent couples conceiving fetuses severely affected by known genetic disorders, with ongoing pregnancy and implantation rates similar to those for in-vitro fertilisation for routine infertility treatment.

  20. Light pollution is greatest within migration passage areas for nocturnally-migrating birds around the world.

    Science.gov (United States)

    Cabrera-Cruz, Sergio A; Smolinsky, Jaclyn A; Buler, Jeffrey J

    2018-02-19

    Excessive or misdirected artificial light at night (ALAN) produces light pollution that influences several aspects of the biology and ecology of birds, including disruption of circadian rhythms and disorientation during flight. Many migrating birds traverse large expanses of land twice every year at night when ALAN illuminates the sky. Considering the extensive and increasing encroachment of light pollution around the world, we evaluated the association of the annual mean ALAN intensity over land within the geographic ranges of 298 nocturnally migrating bird species with five factors: phase of annual cycle, mean distance between breeding and non-breeding ranges, range size, global hemisphere of range, and IUCN category of conservation concern. Light pollution within geographic ranges was relatively greater during the migration season, for shorter-distance migrants, for species with smaller ranges, and for species in the western hemisphere. Our results suggest that migratory birds may be subject to the effects of light pollution particularly during migration, the most critical stage in their annual cycle. We hope these results will spur further research on how light pollution affects not only migrating birds, but also other highly mobile animals throughout their annual cycle.

  1. Samtidskunst og migration

    DEFF Research Database (Denmark)

    Petersen, Anne Ring

    2010-01-01

    "Samtidskunst og migration. En oversigt over faglitteraturen" er en forskningsoversigt der gør status over hvad der hidtil er skrevet inden for det kunsthistoriske område om vor tids billedkunst og migration som politisk, socialt og kulturelt fænomen, primært i forbindelse med immigration til...

  2. The Great Migration.

    Science.gov (United States)

    Trotter, Joe William, Jr.

    2002-01-01

    Describes the migration of African Americans in the United States and the reasons why African Americans migrated from the south. Focuses on issues, such as the effect of World War I, the opportunities offered in the north, and the emergence of a black industrial working class. (CMK)

  3. Migrating Art History

    DEFF Research Database (Denmark)

    Ørum, Tania

    2012-01-01

    Review of Hiroko Ikegami, The Great Migrator. Robert Rauschenberg and the Global Rise of American Art. Cambridge Mass., The MIT Press, 2010. 277 pages. ISBN 978-0-262-01425-0.......Review of Hiroko Ikegami, The Great Migrator. Robert Rauschenberg and the Global Rise of American Art. Cambridge Mass., The MIT Press, 2010. 277 pages. ISBN 978-0-262-01425-0....

  4. College Student Migration.

    Science.gov (United States)

    Fenske, Robert H.; And Others

    This study examines the background characteristics of two large national samples of first-time enrolled freshmen who (a) attended college within their state of residence but away from their home community, (b) migrated to a college in an adjacent state, (c) migrated to a college in a distant state, and (d) attended college in their home community.…

  5. Migration, klima og sundhed

    DEFF Research Database (Denmark)

    Tellier, Siri; Carballo, Manuel

    2009-01-01

    Many tentative connections have been postulated between migration and climate. This article points to rural-urban migration, particularly into low elevation urban slums prone to flooding as an issue needing urgent attention by health professionals. It also notes the no-man's land in which environ...

  6. Migration in Burkina Faso

    NARCIS (Netherlands)

    Wouterse, F.S.

    2007-01-01

    Migration plays an important role in development and as a strategy for poverty reduction. A recent World Bank investigation finds a significant positive relationship between international migration and poverty reduction at the country level (Adams and Page 2003). Burkina Faso, whose conditions for

  7. Migration, Narration, Identity

    DEFF Research Database (Denmark)

    Leese, Peter

    (co-editor with Carly McLaughlin and Wladyslaw Witalisz) This book presents articles resulting from joint research on the representations of migration conducted in connection with the Erasmus Intensive Programme entitled «Migration and Narration» taught to groups of international students over...

  8. The Globalisation of migration

    Directory of Open Access Journals (Sweden)

    Milan Mesić

    2002-04-01

    Full Text Available The paper demonstrates that contemporary international migration is a constitutive part of the globalisation process. After defining the concepts of globalisation and the globalisation of migration, the author discusses six key themes, linking globalisation and international migration (“global cities”, the scale of migration; diversification of migration flows; globalisation of science and education; international migration and citizenship; emigrant communities and new identities. First, in accordance with Saskia Sassen’s analysis, the author rejects the wide-spread notion that unqualified migrants have lost an (important role in »global cities«, i.e. in the centres of the new (global economy. Namely, the post-modern service sector cannot function without the support of a wide range of auxiliary unqualified workers. Second, a critical comparison with traditional overseas mass migration to the USA at the turn of the 19th and 20th centuries indicates that present international migration is, perhaps, less extensive – however it is important to take into consideration various limitations that previously did not exist, and thus the present migration potential is in really greater. Third, globalisation is more evident in a diversification of the forms of migration: the source area of migrants to the New World and Europe has expanded to include new regions in the world; new immigration areas have arisen (the Middle East, new industrial countries of the Far East, South Europe; intra-regional migration has intensified. Forth, globalisation is linked to an increased migration of experts and the pessimistic notion of a brain drain has been replaced by the optimistic idea of a brain gain. Fifth, contemporary international migration has been associated with a crisis of the national model of citizenship. Sixth, the interlinking of (migrant cultural communities regardless of distance and the physical proximity of cultural centres (the

  9. Malaysia and forced migration

    Directory of Open Access Journals (Sweden)

    Arzura Idris

    2012-06-01

    Full Text Available This paper analyzes the phenomenon of “forced migration” in Malaysia. It examines the nature of forced migration, the challenges faced by Malaysia, the policy responses and their impact on the country and upon the forced migrants. It considers forced migration as an event hosting multifaceted issues related and relevant to forced migrants and suggests that Malaysia has been preoccupied with the issue of forced migration movements. This is largely seen in various responses invoked from Malaysia due to “south-south forced migration movements.” These responses are, however, inadequate in terms of commitment to the international refugee regime. While Malaysia did respond to economic and migration challenges, the paper asserts that such efforts are futile if she ignores issues critical to forced migrants.

  10. SEM characterization of the martensitic transformation induced by mechanical compression cycling in a β-(111) Cu-20.85 Zn-6.15Al shape memory single crystal

    International Nuclear Information System (INIS)

    Gil, F.J.; Guilemany, J.M.

    1991-01-01

    On submitting a Cu-Zn-Al shape memory alloy β phase sample to stress compressions cycles, stabilization of martensitic plates which do not retransform on unloading stress, can be seen. On increasing the number of cycles a greater amount of stabilized martensite plates can be observed as well as the growth of some at the expense of others, thus producing thicker plates in preferential orientations. Finally, the aluminium rich martensite nuclei appear, situated in the intersection between different martensitic variants which contain greater stored elastic energy which in turn favours transformation. (orig.) [de

  11. Incentives and disincentives: international migration.

    Science.gov (United States)

    Bhagwati, J N

    1984-01-01

    International migration is largely controlled by disincentives, or quotas, on immigration rather than checks on emigrations. Societies generally feel they have a right to exclude others from their boundaries, but they also usually feel that they do not have a right to control emigration. The single-planetary approach holds that people have the right to live wherever they like on the planet, and the cosmopolitan-utilitarian approach believes the same for reasons of world efficiency. The current feeling that societies have the right to exclude others may be explained best by territoriality in human animals. People also believe that their culture will be diluted if too many outsiders enter. In many cases, immigration systems cannot really control immigration, as in the cases of long landlocked borders between the US and Mexico and between Bangladesh and Assam. Immigration systems also contain legal loopholes. For example, in the US it is easier to get a student visa and convert to immigrant status than to gain immigrant status directly. Loopholes lead to plugs, which lead in turn to more loopholes. An upsurge in requests for political asylum followed increased restrictions on immigration in Western Europe. The US has investigated foreign aid and foreign investments to Mexico and Haiti to curb the flow of illegal migrants. The author suggests that foreign investments may lead to more migration because of the creation of a new proletariat used to the ways of developed countries. An estimate of what would happen if all immigration control were removed worldwide concludes that efficiency and income distribution would improve worldwide. Most migration from developing to developed countries currently consists of the migration of skilled professionals, the brain drain. The author proposes a tax on these professionals to be paid to the country of origin to compensate them for the loss in education and training. The author summarizes the differences between the West German

  12. Migration and AIDS.

    Science.gov (United States)

    1998-01-01

    This article presents the perspectives of UNAIDS and the International Organization for Migration (IOM) on migration and HIV/AIDS. It identifies research and action priorities and policy issues, and describes the current situation in major regions of the world. Migration is a process. Movement is enhanced by air transport, rising international trade, deregulation of trade practices, and opening of borders. Movements are restricted by laws and statutes. Denial to freely circulate and obtain asylum is associated with vulnerability to HIV infections. A UNAIDS policy paper in 1997 and IOM policy guidelines in 1988 affirm that refugees and asylum seekers should not be targeted for special measures due to HIV/AIDS. There is an urgent need to provide primary health services for migrants, voluntary counseling and testing, and more favorable conditions. Research is needed on the role of migration in the spread of HIV, the extent of migration, availability of health services, and options for HIV prevention. Research must be action-oriented and focused on vulnerability to HIV and risk taking behavior. There is substantial mobility in West and Central Africa, economic migration in South Africa, and nonvoluntary migration in Angola. Sex workers in southeast Asia contribute to the spread. The breakup of the USSR led to population shifts. Migrants in Central America and Mexico move north to the US where HIV prevalence is higher.

  13. Domal salt brine migration experiments at Avery Island, Louisiana

    International Nuclear Information System (INIS)

    Krause, W.B.; Gnirk, P.F.

    1981-01-01

    Three in-situ brine migration experiments were performed in domal salt in the Avery Island mine located in southwestern Louisiana. The primary measurements included temperature, moisture collection, and pre- and post-test permeability at the experimental sites. Experimental data are discussed and compared with calculations based on the single-crystal brine migration theory. Comparisons indicate reasonable agreement between experiment and theory

  14. Labor migration in Asia.

    Science.gov (United States)

    Martin, P L

    1991-01-01

    "A recent conference sponsored by the United Nations Center for Regional Development (UNCRD) in Nagoya, Japan examined the growing importance of labor migration for four major Asian labor importers (Japan, Hong Kong, Malaysia, and Singapore) and five major labor exporters (Bangladesh, Korea, Pakistan, Philippines, and Thailand).... The conference concluded that international labor migration would increase within Asia because the tight labor markets and rising wages which have stimulated Japanese investment in other Asian nations, for example, have not been sufficient to eliminate migration push and pull forces...." excerpt

  15. Multi-stage versus single-stage inflation and deflation cycle for alternating low pressure air mattresses to prevent pressure ulcers in hospitalised patients: a randomised-controlled clinical trial.

    Science.gov (United States)

    Demarré, L; Beeckman, D; Vanderwee, K; Defloor, T; Grypdonck, M; Verhaeghe, S

    2012-04-01

    The duration and the amount of pressure and shear must be reduced in order to minimize the risk of pressure ulcer development. Alternating low pressure air mattresses with multi-stage inflation and deflation cycle of the air cells have been developed to relieve pressure by sequentially inflating and deflating the air cells. Evidence about the effectiveness of this type of mattress in clinical practice is lacking. This study aimed to compare the effectiveness of an alternating low pressure air mattress that has a standard single-stage inflation and deflation cycle of the air cells with an alternating low pressure air mattress with multi-stage inflation and deflation cycle of the air cells. A randomised controlled trial was performed in a convenience sample of 25 wards in five hospitals in Belgium. In total, 610 patients were included and randomly assigned to the experimental group (n=298) or the control group (n=312). In the experimental group, patients were allocated to an alternating low pressure air mattress with multi-stage inflation and deflation cycle of the air cells. In the control group, patients were allocated to an alternating low pressure air mattress with a standard single-stage inflation and deflation cycle of the air cells. The outcome was defined as cumulative pressure ulcer incidence (Grade II-IV). An intention-to-treat analysis was performed. There was no significant difference in cumulative pressure ulcer incidence (Grade II-IV) between both groups (Exp.=5.7%, Contr.=5.8%, p=0.97). When patients developed a pressure ulcer, the median time was 5.0 days in the experimental group (IQR=3.0-8.5) and 8.0 days in the control group (IQR=3.0-8.5) (Mann-Whitney U-test=113, p=0.182). The probability to remain pressure ulcer free during the observation period in this trial did not differ significantly between the experimental group and the control group (log-rank χ(2)=0.013, df=1, p=0.911). An alternating low pressure air mattress with multi-stage inflation

  16. Two cycles of cisplatin-based chemotherapy for low-volume stage II seminoma: results of a retrospective, single-center case series.

    Science.gov (United States)

    Pichler, Renate; Leonhartsberger, Nicolai; Stöhr, Brigitte; Horninger, Wolfgang; Steiner, Hannes

    2012-01-01

    To report on the oncological outcome and toxicity of patients treated with 2 cycles of cisplatin-based chemotherapy for low-volume metastatic stage II seminoma. We retrospectively identified a case series of 15 patients with seminoma stage IIA (26.7%) and IIB (73.3%) who underwent chemotherapy consisting of 2 cycles of cisplatin, etoposide and bleomycin (PEB) (cisplatin 20 mg/m(2) on days 1-5, etoposide 100 mg/m(2) on days 1-5, bleomycin 30 mg on days 1, 8 and 15) according to patient preference (refusing a 3rd cycle of PEB) or institutional practice in the last decades. Complete staging before chemotherapy was available in all patients. Patient age, the side and diameter of the primary tumor, the size of the lymph nodes before and after chemotherapy, acute and late toxicity of chemotherapy, the incidence of second malignancies, the relapse-free rate and cancer-specific mortality were recorded. Chemotherapy was well tolerated and no episode of febrile neutropenia occurred. Thrombocytopenia grade 4 was not seen in any patient, while leukopenia grade 4 was observed in 4 (26.6%) patients. The mean (range) lymph node size decreased significantly from 2.54 cm (1.1-4.0) before chemotherapy to 0.75 cm (0.4-2.2) after chemotherapy (p < 0.001). After a median (range) follow-up of 60 (13-185) months, no patient had relapsed, no patient had died as a result of seminoma and second malignancy was seen in only 1 (6.6%) patient. These excellent long-term results from a retrospective case series of 2 cycles of PEB in stage IIA/IIB seminoma patients represent a hint for further research with a view to reducing treatment burden. However, these incidental findings should be studied in prospective trials prior to drawing any conclusions. Copyright © 2013 S. Karger AG, Basel.

  17. Neuronal Migration Disorders

    Science.gov (United States)

    ... Understanding Sleep The Life and Death of a Neuron Genes At Work In The Brain Order Publications ... birth defects caused by the abnormal migration of neurons in the developing brain and nervous system. In ...

  18. Migration og etnicitet

    DEFF Research Database (Denmark)

    Christiansen, Connie Carøe

    2004-01-01

    Migration og etnicitet er aktuelle og forbundne fænomener, idet migration øger berøringsfladerne mellem befolkningsgrupper. Etniciteter formes i takt med at grænser drages imellem disse grupper. Imod moderniserings-teoriernes forventning forsvandt etnicitet ikke som en traditionel eller oprindelig...... måde at skabe tilhørsforhold på; globalt set fremstår vor tid istedet som en "migrationens tidsalder", der tilsyneladende også er en tidsalder, hvor kulturelle særtræk, i form af etnicitet, udgør vigtige linjer, hvorefter grupper skilller sig ud fra hinanden. Både migration og etnicitet bringer fokus...... den finder sted i modtagerlandet, men nyere perspektiver på migration, som begreber om medborgerskab, transnationalisme og diaspora er eksponenter for, søger udover den nationalstatslige ramme og inddrager konsekvenserne af migrationen for afsenderlande....

  19. Indonesia's migration transition.

    Science.gov (United States)

    Hugo, G

    1995-01-01

    This article describes population movements in Indonesia in the context of rapid and marked social and economic change. Foreign investment in Indonesia is increasing, and global mass media is available to many households. Agriculture is being commercialized, and structural shifts are occurring in the economy. Educational levels are increasing, and women's role and status are shifting. Population migration has increased over the decades, both short and long distance, permanent and temporary, legal and illegal, and migration to and between urban areas. This article focuses specifically on rural-to-urban migration and international migration. Population settlements are dense in the agriculturally rich inner areas of Java, Bali, and Madura. Although the rate of growth of the gross domestic product was 6.8% annually during 1969-94, the World Bank ranked Indonesia as a low-income economy in 1992 because of the large population size. Income per capita is US $670. Indonesia is becoming a large exporter of labor to the Middle East, particularly women. The predominance of women as overseas contract workers is changing women's role and status in the family and is controversial due to the cases of mistreatment. Malaysia's high economic growth rate of over 8% per year means an additional 1.3 million foreign workers and technicians are needed. During the 1980s urban growth increased at a very rapid rate. Urban growth tended to occur along corridors and major transportation routes around urban areas. It is posited that most of the urban growth is due to rural-to-urban migration. Data limitations prevent an exact determination of the extent of rural-to-urban migration. More women are estimated to be involved in movements to cities during the 1980s compared to the 1970s. Recruiters and middlemen have played an important role in rural-to-urban migration and international migration.

  20. Migration and Extension of Solar Active Longitudinal Zones

    Science.gov (United States)

    Gyenge, N.; Baranyi, T.; Ludmány, A.

    2014-02-01

    Solar active longitudes show a characteristic migration pattern in the Carrington coordinate system if they can be identified at all. By following this migration, the longitudinal activity distribution around the center of the band can be determined. The half-width of the distribution is found to be varying in Cycles 21 - 23, and in some time intervals it was as narrow as 20 - 30 degrees. It was more extended around a maximum but it was also narrow when the activity jumped to the opposite longitude. Flux emergence exhibited a quasi-periodic variation within the active zone with a period of about 1.3 years. The path of the active-longitude migration does not support the view that it might be associated with the 11-year solar cycle. These results were obtained for a limited time interval of a few solar cycles and, bearing in mind uncertainties of the migration-path definition, are only indicative. For the major fraction of the dataset no systematic active longitudes were found. Sporadic migration of active longitudes was identified only for Cycles 21 - 22 in the northern hemisphere and Cycle 23 in the southern hemisphere.

  1. Latitudinal migration of sunspots based on the ESAI database

    Science.gov (United States)

    Zhang, Juan; Li, Fu-Yu; Feng, Wen

    2018-01-01

    The latitudinal migration of sunspots toward the equator, which implies there is propagation of the toroidal magnetic flux wave at the base of the solar convection zone, is one of the crucial observational bases for the solar dynamo to generate a magnetic field by shearing of the pre-existing poloidal magnetic field through differential rotation. The Extended time series of Solar Activity Indices (ESAI) elongated the Greenwich observation record of sunspots by several decades in the past. In this study, ESAI’s yearly mean latitude of sunspots in the northern and southern hemispheres during the years 1854 to 1985 is utilized to statistically test whether hemispherical latitudinal migration of sunspots in a solar cycle is linear or nonlinear. It is found that a quadratic function is statistically significantly better at describing hemispherical latitudinal migration of sunspots in a solar cycle than a linear function. In addition, the latitude migration velocity of sunspots in a solar cycle decreases as the cycle progresses, providing a particular constraint for solar dynamo models. Indeed, the butterfly wing pattern with a faster latitudinal migration rate should present stronger solar activity with a shorter cycle period, and it is located at higher latitudinal position, giving evidence to support the Babcock-Leighton dynamo mechanism.

  2. Repeat migration and disappointment.

    Science.gov (United States)

    Grant, E K; Vanderkamp, J

    1986-01-01

    This article investigates the determinants of repeat migration among the 44 regions of Canada, using information from a large micro-database which spans the period 1968 to 1971. The explanation of repeat migration probabilities is a difficult task, and this attempt is only partly successful. May of the explanatory variables are not significant, and the overall explanatory power of the equations is not high. In the area of personal characteristics, the variables related to age, sex, and marital status are generally significant and with expected signs. The distance variable has a strongly positive effect on onward move probabilities. Variables related to prior migration experience have an important impact that differs between return and onward probabilities. In particular, the occurrence of prior moves has a striking effect on the probability of onward migration. The variable representing disappointment, or relative success of the initial move, plays a significant role in explaining repeat migration probabilities. The disappointment variable represents the ratio of actural versus expected wage income in the year after the initial move, and its effect on both repeat migration probabilities is always negative and almost always highly significant. The repeat probabilities diminish after a year's stay in the destination region, but disappointment in the most recent year still has a bearing on the delayed repeat probabilities. While the quantitative impact of the disappointment variable is not large, it is difficult to draw comparisons since similar estimates are not available elsewhere.

  3. Double targeting of Survivin and XIAP radiosensitizes 3D grown human colorectal tumor cells and decreases migration

    International Nuclear Information System (INIS)

    Hehlgans, Stephanie; Petraki, Chrysi; Reichert, Sebastian; Cordes, Nils; Rödel, Claus; Rödel, Franz

    2013-01-01

    Background and purpose: In the present study, we aimed to investigate the effect of single and double knockdown of the inhibitor of apoptosis proteins (IAP) Survivin and X-linked IAP (XIAP) on three-dimensional (3D) clonogenic survival, migration capacity and underlying signaling pathways. Materials and methods: Colorectal cancer cell lines (HCT-15, SW48, SW480, SW620) were subjected to siRNA-mediated single or Survivin/XIAP double knockdown followed by 3D colony forming assays, cell cycle analysis, Caspase activity assays, migration assays, matrigel transmigration assays and Western blotting (Survivin, XIAP, Focal adhesion kinase (FAK), p-FAK Y397, Akt1, p-Akt1 S473, Extracellular signal-regulated kinase (ERK1/2), p-ERK1/2 T202/Y204, Glycogen synthase kinase (GSK)3β, p-GSK3β S9, nuclear factor (NF)-κB p65). Results: While basal cell survival was altered cell line-dependently, Survivin or XIAP single and Survivin/XIAP double knockdown enhanced cellular radiosensitivity of all tested cancer cell lines grown in 3D. Particularly double knockdown conditions revealed accumulation of cells in G2/M, increased subG1 fraction, elevated Caspase 3/7 activity, and reduced migration. Intracellular signaling showed dephosphorylation of FAK and Akt1 upon Survivin and/or Survivin/XIAP silencing. Conclusions: Our results strengthen the notion of Survivin and XIAP to act as radiation resistance factors and further indicate that these apoptosis-regulating proteins are also functioning in cell cycling and cell migration

  4. Substrate Curvature Regulates Cell Migration -A Computational Study

    Science.gov (United States)

    He, Xiuxiu; Jiang, Yi

    Cell migration in host microenvironment is essential to cancer etiology, progression and metastasis. Cellular processes of adhesion, cytoskeletal polymerization, contraction, and matrix remodeling act in concert to regulate cell migration, while local extracellular matrix architecture modulate these processes. In this work we study how stromal microenvironment with native and cell-derived curvature at micron-meter scale regulate cell motility pattern. We developed a 3D model of single cell migration on a curved substrate. Mathematical analysis of cell morphological adaption to the cell-substrate interface shows that cell migration on convex surfaces deforms more than on concave surfaces. Both analytical and simulation results show that curved surfaces regulate the cell motile force for cell's protruding front through force balance with focal adhesion and cell contraction. We also found that cell migration on concave substrates is more persistent. These results offer a novel biomechanical explanation to substrate curvature regulation of cell migration. NIH 1U01CA143069.

  5. Managing migration: the Brazilian case

    OpenAIRE

    Eduardo L. G. Rios-Neto

    2005-01-01

    The objective of this paper is to present the Brazilian migration experience and its relationship with migration management. The article is divided into three parts. First, it reviews some basic facts regarding Brazilian immigration and emigration processes. Second, it focuses on some policy and legal issues related to migration. Finally, it addresses five issues regarding migration management in Brazil.

  6. A single preovulatory administration of ulipristal acetate affects the decidualization process of the human endometrium during the receptive period of the menstrual cycle.

    Science.gov (United States)

    Lira-Albarrán, Saúl; Durand, Marta; Barrera, David; Vega, Claudia; Becerra, Rocio García; Díaz, Lorenza; García-Quiroz, Janice; Rangel, Claudia; Larrea, Fernando

    2018-04-27

    In order to get further information on the effects of ulipristal acetate (UPA) upon the process of decidualization of endometrium, a functional analysis of the differentially expressed genes in endometrium (DEG) from UPA treated-versus control-cycles of normal ovulatory women was performed. A list of 1183 endometrial DEG, from a previously published study by our group, was submitted to gene ontology, gene enrichment and ingenuity pathway analyses (IPA). This functional analysis showed that decidualization was a biological process overrepresented. Gene set enrichment analysis identified LIF, PRL, IL15 and STAT3 among the most down-regulated genes within the JAK STAT canonical pathway. IPA showed that decidualization of uterus was a bio-function predicted as inhibited by UPA. The results demonstrated that this selective progesterone receptor modulator, when administered during the periovulatory phase of the menstrual cycle, may affect the molecular mechanisms leading to endometrial decidualization in response to progesterone during the period of maximum embryo receptivity. Copyright © 2018. Published by Elsevier B.V.

  7. Influence of speciation on the geospheric migration of radionuclides

    International Nuclear Information System (INIS)

    Hadermann, J.; Schweingruber, M.

    1982-01-01

    For geosphere transport calculations in safety analyses of waste repositories it is generally assumed that the retardation of a migrating radionuclide is characterized by a single retention factor. However, in groundwater, radionuclides exist in various chemical forms with strongly differing sorption properties. We consider the effect of pseudo first order chemical reactions in liquid phase on migration. Conditions are derived under which local equilibrium in liquid phase is well fulfilled and migration is governed by a single effective retention factor. It is argued that in geosphere transport, equilibrium is likely to exist even when laboratory measurements show chromatographic separations. (author)

  8. SU-D-207A-07: The Effects of Inter-Cycle Respiratory Motion Variation On Dose Accumulation in Single Fraction MR-Guided SBRT Treatment of Renal Cell Carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Stemkens, B; Glitzner, M; Kontaxis, C; Prins, F; Crijns, SPM; Kerkmeijer, L; Lagendijk, J; Berg, CAT van den; Tijssen, RHN [Department of Radiotherapy, University Medical Center Utrecht, Utrecht (Netherlands); Denis de Senneville, B [Imaging Division, University Medical Center Utrecht, Utrecht (Netherlands); IMB, UMR 5251 CNRS/University of Bordeaux (France)

    2016-06-15

    Purpose: To assess the dose deposition in simulated single-fraction MR-Linac treatments of renal cell carcinoma, when inter-cycle respiratory motion variation is taken into account using online MRI. Methods: Three motion characterization methods, with increasing complexity, were compared to evaluate the effect of inter-cycle motion variation and drifts on the accumulated dose for an SBRT kidney MR-Linac treatment: 1) STATIC, in which static anatomy was assumed, 2) AVG-RESP, in which 4D-MRI phase-volumes were time-weighted, based on the respiratory phase and 3) PCA, in which 3D volumes were generated using a PCA-model, enabling the detection of inter-cycle variations and drifts. An experimental ITV-based kidney treatment was simulated in a 1.5T magnetic field on three volunteer datasets. For each volunteer a retrospectively sorted 4D-MRI (ten respiratory phases) and fast 2D cine-MR images (temporal resolution = 476ms) were acquired to simulate MR-imaging during radiation. For each method, the high spatio-temporal resolution 3D volumes were non-rigidly registered to obtain deformation vector fields (DVFs). Using the DVFs, pseudo-CTs (generated from the 4D-MRI) were deformed and the dose was accumulated for the entire treatment. The accuracies of all methods were independently determined using an additional, orthogonal 2D-MRI slice. Results: Motion was most accurately estimated using the PCA method, which correctly estimated drifts and inter-cycle variations (RMSE=3.2, 2.2, 1.1mm on average for STATIC, AVG-RESP and PCA, compared to the 2DMRI slice). Dose-volume parameters on the ITV showed moderate changes (D99=35.2, 32.5, 33.8Gy for STATIC, AVG-RESP and PCA). AVG-RESP showed distinct hot/cold spots outside the ITV margin, which were more distributed for the PCA scenario, since inter-cycle variations were not modeled by the AVG-RESP method. Conclusion: Dose differences were observed when inter-cycle variations were taken into account. The increased inter-cycle

  9. Prestack depth migration

    International Nuclear Information System (INIS)

    Postma, R.W.

    1991-01-01

    Two lines form the southern North Sea, with known velocity inhomogeneities in the overburden, have been pre-stack depth migrated. The pre-stack depth migrations are compared with conventional processing, one with severe distortions and one with subtle distortions on the conventionally processed sections. The line with subtle distortions is also compared with post-stack depth migration. The results on both lines were very successful. Both have already influenced drilling decisions, and have caused a modification of structural interpretation in the respective areas. Wells have been drilled on each of the lines, and well tops confirm the results. In fact, conventional processing led to incorrect locations for the wells, both of which were dry holes. The depth migrated sections indicate the incorrect placement, and on one line reveals a much better drilling location. This paper reports that even though processing costs are high for pre-stack depth migration, appropriate use can save millions of dollars in dry-hole expense

  10. Migration = cloning; aliasiing

    DEFF Research Database (Denmark)

    Hüttel, Hans; Kleist, Josva; Nestmann, Uwe

    1999-01-01

    In Obliq, a lexically scoped, distributed, object-oriented programming language, object migration was suggested as the creation of a copy of an object’s state at the target site, followed by turning the object itself into an alias, also called surrogate, for the remote copy. We consider the creat......In Obliq, a lexically scoped, distributed, object-oriented programming language, object migration was suggested as the creation of a copy of an object’s state at the target site, followed by turning the object itself into an alias, also called surrogate, for the remote copy. We consider...... the creation of object surrogates as an abstraction of the abovementioned style of migration. We introduce Øjeblik, a distribution-free subset of Obliq, and provide three different configuration-style semantics, which only differ in the respective aliasing model. We show that two of the semantics, one of which...... matches Obliq’s implementation, render migration unsafe, while our new proposal for a third semantics is provably safe. Our work suggests a straightforward repair of Obliq’s aliasing model such that it allows programs to safely migrate objects....

  11. Sulfur cycle

    Digital Repository Service at National Institute of Oceanography (India)

    LokaBharathi, P.A.

    Microbes, especially bacteria, play an important role in oxidative and reductive cycle of sulfur. The oxidative part of the cycle is mediated by photosynthetic bacteria in the presence of light energy and chemosynthetic forms in the absence of light...

  12. En fornemmelse for migration

    DEFF Research Database (Denmark)

    Schütze, Laura Maria

    Afhandlingen undersøger, hvordan sted, museets rolle som aktør og religion er relevante for produktionen af migration på Immigrantmuseet (2012) og i Københavns Museums udstilling At blive københavner (2010). Afhandlingen er baseret på udstillingsanalyse samt interview med relevant museumsfagligt......, anvendes som virkemidler til at nuancere migration og distancere udstillingen fra den offentlige debat om indvandring. Afhandlingen peger på, at produktionen af den nyere danske historie på museum er præget af et fravær af religion. Det skyldes, at de museumsfaglige praksisser og traditioner afspejler en...... identiteter, som vi tager for givet: nationer, byer, kvinder - såvel som migration og religion. Afhandlingen argumenterer følgelig for, at museernes produktion af (materiel) religion er et særdeles relevant, men kun ringe udforsket, genstandsfelt for religionssociologien....

  13. Oceanic migration and spawning of anguillid eels.

    Science.gov (United States)

    Tsukamoto, K

    2009-06-01

    Many aspects of the life histories of anguillid eels have been revealed in recent decades, but the spawning migrations of their silver eels in the open ocean still remains poorly understood. This paper overviews what is known about the migration and spawning of anguillid species in the ocean. The factors that determine exactly when anguillid eels will begin their migrations are not known, although environmental influences such as lunar cycle, rainfall and river discharge seem to affect their patterns of movement as they migrate towards the ocean. Once in the ocean on their way to the spawning area, silver eels probably migrate in the upper few hundred metres, while reproductive maturation continues. Although involvement of a magnetic sense or olfactory cues seems probable, how they navigate or what routes they take are still a matter of speculation. There are few landmarks in the open ocean to define their spawning areas, other than oceanographic or geological features such as oceanic fronts or seamounts in some cases. Spawning of silver eels in the ocean has never been observed, but artificially matured eels of several species have exhibited similar spawning behaviours in the laboratory. Recent collections of mature adults and newly spawned preleptocephali in the spawning area of the Japanese eel Anguilla japonica have shown that spawning occurs during new moon periods in the North Equatorial Current region near the West Mariana Ridge. These data, however, show that the latitude of the spawning events can change among months and years depending on oceanographic conditions. Changes in spawning location of this and other anguillid species may affect their larval transport and survival, and appear to have the potential to influence recruitment success. A greater understanding of the spawning migration and the choice of spawning locations by silver eels is needed to help conserve declining anguillid species.

  14. What's driving migration?

    Science.gov (United States)

    Kane, H

    1995-01-01

    During the 1990s investment in prevention of international or internal migration declined, and crisis intervention increased. The budgets of the UN High Commissioner for Refugees and the UN Development Program remained about the same. The operating assumption is that war, persecution, famine, and environmental and social disintegration are inevitable. Future efforts should be directed to stabilizing populations through investment in sanitation, public health, preventive medicine, land tenure, environmental protection, and literacy. Forces pushing migration are likely to increase in the future. Forces include depletion of natural resources, income disparities, population pressure, and political disruption. The causes of migration are not constant. In the past, migration occurred during conquests, settlement, intermarriage, or religious conversion and was a collective movement. Current migration involves mass movement of individuals and the struggle to survive. There is new pressure to leave poor squatter settlements and the scarcities in land, water, and food. The slave trade between the 1500s and the 1800s linked continents, and only 2-3 million voluntarily crossed national borders. Involuntary migration began in the early 1800s when European feudal systems were in a decline, and people sought freedom. Official refugees, who satisfy the strict 1951 UN definition, increased from 15 million in 1980 to 23 million in 1990 but remained a small proportion of international migrants. Much of the mass movement occurs between developing countries. Migration to developed countries is accompanied by growing intolerance, which is misinformed. China practices a form of "population transfer" in Tibet in order to dilute Tibetan nationalism. Colonization of countries is a new less expensive form of control over territory. Eviction of minorities is another popular strategy in Iraq. Public works projects supported by foreign aid displace millions annually. War and civil conflicts

  15. Unix Application Migration Guide

    CERN Document Server

    Microsoft. Redmond

    2003-01-01

    Drawing on the experience of Microsoft consultants working in the field, as well as external organizations that have migrated from UNIX to Microsoft® Windows®, this guide offers practical, prescriptive guidance on the issues you are likely to face when porting existing UNIX applications to the Windows operating system environment. Senior IT decision makers, network managers, and operations managers will get real-world guidance and best practices on planning and implementation issues to understand the different methods through which migration or co-existence can be accomplished. Also detailing

  16. Migrating for a Profession

    DEFF Research Database (Denmark)

    Olwig, Karen Fog

    2015-01-01

    a strong sense of agency and self-empowerment. In the post-WWII period, numerous Caribbean women trained in nursing at British hospitals that have been described as marred by race and gender related inequality and associated forms of exploitation. Yet, the nurses interviewed about this training emphasised......Youths from the Global South migrating for further education often face various forms of discrimination. This Caribbean case study discusses how conditions in the home country can provide a foundation for educational migration that helps the migrants overcome such obstacles and even develop...... in which it enabled these Caribbean women to stake out a new life for themselves....

  17. Rolling cycle amplification based single-color quantum dots–ruthenium complex assembling dyads for homogeneous and highly selective detection of DNA

    Energy Technology Data Exchange (ETDEWEB)

    Su, Chen; Liu, Yufei; Ye, Tai; Xiang, Xia; Ji, Xinghu; He, Zhike, E-mail: zhkhe@whu.edu.cn

    2015-01-01

    Graphical abstract: A universal, label-free, homogeneous, highly sensitive, and selective fluorescent biosensor for DNA detection is developed by using rolling-circle amplification (RCA) based single-color quantum dots–ruthenium complex (QDs–Ru) assembling dyads. - Highlights: • The single-color QDs–Ru assembling dyads were applied in homogeneous DNA assay. • This biosensor exhibited high selectivity against base mismatched sequences. • This biosensor could be severed as universal platform for the detection of ssDNA. • This sensor could be used to detect the target in human serum samples. • This DNA sensor had a good selectivity under the interference of other dsDNA. - Abstract: In this work, a new, label-free, homogeneous, highly sensitive, and selective fluorescent biosensor for DNA detection is developed by using rolling-circle amplification (RCA) based single-color quantum dots–ruthenium complex (QDs–Ru) assembling dyads. This strategy includes three steps: (1) the target DNA initiates RCA reaction and generates linear RCA products; (2) the complementary DNA hybridizes with the RCA products to form long double-strand DNA (dsDNA); (3) [Ru(phen){sub 2}(dppx)]{sup 2+} (dppx = 7,8-dimethyldipyrido [3,2-a:2′,3′-c] phenanthroline) intercalates into the long dsDNA with strong fluorescence emission. Due to its strong binding propensity with the long dsDNA, [Ru(phen){sub 2}(dppx)]{sup 2+} is removed from the surface of the QDs, resulting in restoring the fluorescence of the QDs, which has been quenched by [Ru(phen){sub 2}(dppx)]{sup 2+} through a photoinduced electron transfer process and is overlaid with the fluorescence of dsDNA bonded Ru(II) polypyridyl complex (Ru-dsDNA). Thus, high fluorescence intensity is observed, and is related to the concentration of target. This sensor exhibits not only high sensitivity for hepatitis B virus (HBV) ssDNA with a low detection limit (0.5 pM), but also excellent selectivity in the complex matrix. Moreover

  18. DISCERNING EXOPLANET MIGRATION MODELS USING SPIN-ORBIT MEASUREMENTS

    International Nuclear Information System (INIS)

    Morton, Timothy D.; Johnson, John Asher

    2011-01-01

    We investigate the current sample of exoplanet spin-orbit measurements to determine whether a dominant planet migration channel can be identified, and at what confidence. We use the predictions of Kozai migration plus tidal friction and planet-planet scattering as our misalignment models, and we allow for a fraction of intrinsically aligned systems, explainable by disk migration. Bayesian model comparison demonstrates that the current sample of 32 spin-orbit measurements strongly favors a two-mode migration scenario combining planet-planet scattering and disk migration over a single-mode Kozai migration scenario. Our analysis indicates that between 34% and 76% of close-in planets (95% confidence) migrated via planet-planet scattering. Separately analyzing the subsample of 12 stars with T eff >6250 K-which Winn et al. predict to be the only type of stars to maintain their primordial misalignments-we find that the data favor a single-mode scattering model over Kozai with 85% confidence. We also assess the number of additional hot star spin-orbit measurements that will likely be necessary to provide a more confident model selection, finding that an additional 20-30 measurement has a >50% chance of resulting in a 95% confident model selection, if the current model selection is correct. While we test only the predictions of particular Kozai and scattering migration models in this work, our methods may be used to test the predictions of any other spin-orbit misaligning mechanism.

  19. How neurons migrate: a dynamic in-silico model of neuronal migration in the developing cortex

    LENUS (Irish Health Repository)

    Setty, Yaki

    2011-09-30

    Abstract Background Neuronal migration, the process by which neurons migrate from their place of origin to their final position in the brain, is a central process for normal brain development and function. Advances in experimental techniques have revealed much about many of the molecular components involved in this process. Notwithstanding these advances, how the molecular machinery works together to govern the migration process has yet to be fully understood. Here we present a computational model of neuronal migration, in which four key molecular entities, Lis1, DCX, Reelin and GABA, form a molecular program that mediates the migration process. Results The model simulated the dynamic migration process, consistent with in-vivo observations of morphological, cellular and population-level phenomena. Specifically, the model reproduced migration phases, cellular dynamics and population distributions that concur with experimental observations in normal neuronal development. We tested the model under reduced activity of Lis1 and DCX and found an aberrant development similar to observations in Lis1 and DCX silencing expression experiments. Analysis of the model gave rise to unforeseen insights that could guide future experimental study. Specifically: (1) the model revealed the possibility that under conditions of Lis1 reduced expression, neurons experience an oscillatory neuron-glial association prior to the multipolar stage; and (2) we hypothesized that observed morphology variations in rats and mice may be explained by a single difference in the way that Lis1 and DCX stimulate bipolar motility. From this we make the following predictions: (1) under reduced Lis1 and enhanced DCX expression, we predict a reduced bipolar migration in rats, and (2) under enhanced DCX expression in mice we predict a normal or a higher bipolar migration. Conclusions We present here a system-wide computational model of neuronal migration that integrates theory and data within a precise

  20. How neurons migrate: a dynamic in-silico model of neuronal migration in the developing cortex

    Directory of Open Access Journals (Sweden)

    Skoblov Nikita

    2011-09-01

    Full Text Available Abstract Background Neuronal migration, the process by which neurons migrate from their place of origin to their final position in the brain, is a central process for normal brain development and function. Advances in experimental techniques have revealed much about many of the molecular components involved in this process. Notwithstanding these advances, how the molecular machinery works together to govern the migration process has yet to be fully understood. Here we present a computational model of neuronal migration, in which four key molecular entities, Lis1, DCX, Reelin and GABA, form a molecular program that mediates the migration process. Results The model simulated the dynamic migration process, consistent with in-vivo observations of morphological, cellular and population-level phenomena. Specifically, the model reproduced migration phases, cellular dynamics and population distributions that concur with experimental observations in normal neuronal development. We tested the model under reduced activity of Lis1 and DCX and found an aberrant development similar to observations in Lis1 and DCX silencing expression experiments. Analysis of the model gave rise to unforeseen insights that could guide future experimental study. Specifically: (1 the model revealed the possibility that under conditions of Lis1 reduced expression, neurons experience an oscillatory neuron-glial association prior to the multipolar stage; and (2 we hypothesized that observed morphology variations in rats and mice may be explained by a single difference in the way that Lis1 and DCX stimulate bipolar motility. From this we make the following predictions: (1 under reduced Lis1 and enhanced DCX expression, we predict a reduced bipolar migration in rats, and (2 under enhanced DCX expression in mice we predict a normal or a higher bipolar migration. Conclusions We present here a system-wide computational model of neuronal migration that integrates theory and data within a

  1. Migrating the Light

    DEFF Research Database (Denmark)

    Sørensen, Bent

    The migration of Blaga’s universalist, even centralist poems from Romanian of the first third of the 20th C. into American of the first fifth of the 21st C. illustrates the uses of Pierre Joris’s nomadic methods. My translations of Blaga read well for a teenage audience whose only exposure to lit...

  2. Describing migration spatial structure

    NARCIS (Netherlands)

    Rogers, A; Willekens, F; Little, J; Raymer, J

    The age structure of a population is a fundamental concept in demography and is generally depicted in the form of an age pyramid. The spatial structure of an interregional system of origin-destination-specific migration streams is, however, a notion lacking a widely accepted definition. We offer a

  3. Brain Migration Revisited

    Science.gov (United States)

    Vinokur, Annie

    2006-01-01

    The "brain drain/brain gain" debate has been going on for the past 40 years, with irresolvable theoretical disputes and unenforceable policy recommendations that economists commonly ascribe to the lack of reliable empirical data. The recent report of the World Bank, "International migration, remittances and the brain drain", documents the…

  4. Dispersal and migration

    Directory of Open Access Journals (Sweden)

    Schwarz, C.

    2004-06-01

    Full Text Available Ringing of birds unveiled many aspects of avian migration and dispersal movements. However, there is even much more to be explored by the use of ringing and other marks. Dispersal is crucial in understanding the initial phase of migration in migrating birds as it is to understand patterns and processes of distribution and gene flow. So far, the analysis of migration was largely based on analysing spatial and temporal patters of recoveries of ringed birds. However, there are considerable biases and pitfalls in using recoveries due to spatial and temporal variation in reporting probabilities. Novel methods are required for future studies separating the confounding effects of spatial and temporal heterogeneity of recovery data and heterogeneity of the landscape as well. These novel approaches should aim a more intensive and novel use of the existing recovery data by taking advantage of, for instance, dynamic and multistate modeling, should elaborate schemes for future studies, and should also include other marks that allow a more rapid data collection, like telemetry, geolocation and global positioning systems, and chemical and molecular markers. The latter appear to be very useful in the delineating origin of birds and connectivity between breeding and non–breeding grounds. Many studies of migration are purely descriptive. However, King and Brooks (King & Brooks, 2004 examine if movement patterns of dolphins change after the introduction of a gillnet ban. Bayesian methods are an interesting approach to this problem as they provide a meaningful measure of the probability that such a change occurred rather than simple yes/no response that is often the result of classical statistical methods. However, the key difficulty of a general implementation of Bayesian methods is the complexity of the modelling —there is no general userfriendly package that is easily accessible to most scientists. Drake and Alisauskas (Drake & Alisauskas, 2004 examine the

  5. Migration and Africa

    DEFF Research Database (Denmark)

    Zoppi, Marco

    2014-01-01

    European powers imposed the nation-state on Africa through colonialism. But even after African independencies, mainstream discourses and government policies have amplified the idea that sedentariness and the state are the only acceptable mode of modernity. Migration is portrayed as a menace...

  6. Migration as Adventure

    DEFF Research Database (Denmark)

    Olwig, Karen Fog

    2018-01-01

    Narratives of adventure constitute a well-established convention of describing travel experiences, yet the significance of this narrative genre in individuals’ accounts of their migration and life abroad has been little investigated. Drawing on Simmel and Bakhtin, among others, this article...

  7. Digitizing migration heritage

    DEFF Research Database (Denmark)

    Marselis, Randi

    2011-01-01

    Museums are increasingly digitizing their collections and making them available to the public on-line. Creating such digital resources may become means for social inclusion. For museums that acknowledge migration history and cultures of ethnic minority groups as important subjects in multiethnic...

  8. The politicisation of migration

    NARCIS (Netherlands)

    van der Brug, W.; D' Amato, G.; Berkhout, J.; Ruedin, D.

    2015-01-01

    Why are migration policies sometimes heavily contested and high on the political agenda? And why do they, at other moments and in other countries, hardly lead to much public debate? The entrance and settlement of migrants in Western Europe has prompted various political reactions. In some countries

  9. Practical Data Migration

    CERN Document Server

    Morris, Johny

    2012-01-01

    This book is for executives and practitioners tasked with the movement of data from old systems to a new repository. It uses a series of steps guaranteed to get the reader from an empty new system to one that is working and backed by the user population. Using this proven methodology will vastly increase the chances of a successful migration.

  10. Migration pathways in soils

    International Nuclear Information System (INIS)

    Gronow, J.R.

    1986-01-01

    This study looked at diffusive migration through three types of deformation; the projectile pathways, hydraulic fractures of the sediments and faults, and was divided into three experimental areas: autoradiography, the determination of diffusion coefficients and electron microscopy of model projectile pathways in clay. For the autoradiography, unstressed samples were exposed to two separate isotopes, Pm-147 (a possible model for Am behaviour) and the poorly sorbed iodide-125. The results indicated that there was no enhanced migration through deformed kaolin samples nor through fractured Great Meteor East (GME) sediment, although some was evident through the projectile pathways in GME and possibly through the GME sheared samples. The scanning electron microscopy of projectile pathways in clay showed that emplacement of a projectile appeared to have no effect on the orientation of particles at distances greater than two projectile radii from the centre of a projectile pathway. It showed that the particles were not simply aligned with the direction of motion of the projectile but that, the closer to the surface of a particular pathway, the closer the particles lay to their original orientation. This finding was of interest from two points of view: i) the ease of migration of a pollutant along the pathway, and ii) possible mechanisms of hole closure. It was concluded that, provided that there is no advective migration, the transport of radionuclides through sediments containing these defects would not be significantly more rapid than in undeformed sediments. (author)

  11. International Migration of Couples

    DEFF Research Database (Denmark)

    Junge, Martin; Munk, Martin D.; Nikolka, Till

    2018-01-01

    Migrant self-selection is important to labor markets and public finances in both origin and destination countries. We develop a theoretical model regarding the migration of dual-earner couples and test it using population-wide administrative data from Denmark. Our model predicts that the probabil...

  12. QA prime-boost vaccination strategy in prevent serotype O FMDV infection using a "single-cycle" alphavirus vector and empty capsid particles

    DEFF Research Database (Denmark)

    Gullberg, Maria; Lohse, Louise; Bøtner, Anette

    Introduction Foot-and-mouth disease (FMD) remains one of the most economically important infectious diseases of production animals globally. Vaccination can help to control this disease, however, current vaccines based on chemically inactivated FMDV, are imperfect and there is a need for new, safe...... and effective vaccines to control FMD. There is no cross protection between the 7 serotypes but serotype O is the most abundant globally. Material and methods The FMDV capsid protein precursor (P1-2A) of strain O1 Manisa has been expressed with the FMDV 3C protease (3Cpro) using a “single cycle” packaged...... alphavirus self-replicating RNA based on Semliki Forest virus (SFV). Purified O1 Manisa empty capsid particles (ECs) have been prepared using a recombinant vaccinia virus expression system. Cattle have been vaccinated with the SFV-FMDV vectors and boosted subsequently with the ECs and then challenged...

  13. Globalization, Migration and Development

    Directory of Open Access Journals (Sweden)

    George, Susan

    2002-01-01

    Full Text Available EnglishMigration may become the most important branch of demography in the earlydecades of the new millennium in a rapidly globalizing world. This paper discusses the causes, costsand benefits of international migration to countries of the South and North, and key issues of commonconcern. International migration is as old as national boundaries, though its nature, volume,direction, causes and consequences have changed. The causes of migration are rooted in the rate ofpopulation growth and the proportion of youth in the population, their education and training,employment opportunities, income differentials in society, communication and transportationfacilities, political freedom and human rights and level of urbanization. Migration benefits the Souththrough remittances of migrants, improves the economic welfare of the population (particularly womenof South countries generally, increases investment, and leads to structural changes in the economy.However, emigration from the South has costs too, be they social or caused by factors such as braindrain. The North also benefits by migration through enhancement of economic growth, development ofnatural resources, improved employment prospects, social development and through exposure toimmigrants' new cultures and lifestyles. Migration also has costs to the North such as of immigrantintegration, a certain amount of destabilization of the economy, illegal immigration, and socialproblems of discrimination and exploitation. Issues common to both North and South include impact onprivate investment, trade, international cooperation, and sustainable development. Both North andSouth face a dilemma in seeking an appropriate balance between importing South's labour or itsproducts and exporting capital and technology from the North.FrenchLa migration est sans doute devenue la partie la plus importante de la démographie des premières décennies du nouveau millénaire dans un monde qui change rapidement. Ce

  14. Migration and Remittances : Recent Developments and Outlook - Transit Migration

    OpenAIRE

    World Bank Group

    2018-01-01

    This Migration and Development Brief reports global trends in migration and remittance flows, as well as developments related to the Global Compact on Migration (GCM), and the Sustainable Development Goal (SDG) indicators for volume of remittances as percentage of gross domestic product (GDP) (SDG indicator 17.3.2), reducing remittance costs (SDG indicator 10.c.1) and recruitment costs (SD...

  15. THE ROMANIAN MIGRATIONAL EVOLUTION PHENOMENON

    Directory of Open Access Journals (Sweden)

    Cristian Raluca

    2009-05-01

    Full Text Available In our contemporary democratic society the migration phenomenon meets unknown valences in any previous societies. Free will and right to self-determination, much exploited by the XX century society., raised the possibility of interpretation of migration

  16. International migration and the gender

    OpenAIRE

    Koropecká, Markéta

    2010-01-01

    My bachelor thesis explores the connection between international migration and gender. Gender, defined as a social, not a biological term, has a huge impact on the migration process. Statistics and expert studies that have been gender sensitive since 1970s demonstrate that women form half of the amount of the international migrants depending on the world region and representing a wide range of the kinds of international migration: family formation and reunification, labour migration, illegal ...

  17. The commercialization of migration.

    Science.gov (United States)

    Abrera-mangahas, M A

    1989-01-01

    International migration is not new to the Philippines. In the recent outflow of contract workers to the Middle East, there is a shift from individual and family initiated migrations to the more organized, highly commercial variety. While profit-taking intermediaries have played some role in the past, the increase in the number and influence of these intermediaries has altered the story of migration decision-making. In 1975, the signing of the bilateral labor agreement between the governments of Iran and the Philippines signalled the rising demand for Filipino contract workers. From 1970 to 1975, the number of Asian migrant workers in the Gulf countries rose from about 120,000 to 370,000. These figures rose dramatically to 3.3 million in 1985. The growing share of organized and commercialized migration has altered migration decision making. Primarily, intermediaries are able to broaden access to foreign job and high wage opportunities. Commercialization effectively raises the transaction costs for contract migration. Studies on recruitment costs and fees show that self-solicited foreign employment costs less than employment obtained through recruitment agents and intermediaries. The difference in the 2 prices is due, not only to overhead costs of intermediation, but more importantly to the rent exacted by agents from having job information and placement rights. In the Philippines in October 1987 the average placement fee was P8000, greatly exceeding the mandated maximum fee level of P5000. This average is understated because the computation includes the 17% who do not pay any fees. The widespread and popular view of recruitment intermediaries is negative, dominated by images of abuses and victims. Private intermediaries and the government bureaucracy need each other. Intermediaries need government; their consistent demand for incentives and protection is indicative. On the other hand, government expands its supervision of control of overseas employment via the

  18. Youth Labor Migration in Nepal

    OpenAIRE

    Bossavie, Laurent; Denisova, Anastasiya

    2018-01-01

    This descriptive study investigates internal and external labor migration by Nepalese youth. External labor migration is separated into the flow to India, which is unregulated, and the flow to other countries, which typically takes the form of temporary contract migration to countries with bilateral labor agreements with Nepal (referred to in Nepal as foreign employment). The study finds t...

  19. Musei del migration heritage / Migration heritage museums

    Directory of Open Access Journals (Sweden)

    Patrizia Dragoni

    2015-01-01

    Since the second half of the 1960s of the 20th century, a profound cultural innovation was accompanied to the radical change in the social, political and economic climate. The anthropological notion of culture as opposed to idealistic vision, the unusual and strong interest in material culture, the enunciation of the concept of cultural property by the Franceschini Commission, the luck of the Public History bring a change of the disciplinary statutes of historical sciences, which begin to attend to social history, focusing on the spontaneous sources of information and initiating experiences of oral history. To all this a remarkable transformation of the themes and of the social function of museums is added. This paper illustrates, in relation to this more general context, the foundation and the dissemination of museums dedicated to the history of migration in Italy and in the world, enunciates their possible social utility for the integration of present migrants in Italy and illustrates, by way of example, the museum recently opened in Recanati.

  20. Superfluid thermodynamic cycle refrigerator

    Science.gov (United States)

    Swift, Gregory W.; Kotsubo, Vincent Y.

    1992-01-01

    A cryogenic refrigerator cools a heat source by cyclically concentrating and diluting the amount of .sup.3 He in a single phase .sup.3 He-.sup.4 He solution. The .sup.3 He in superfluid .sup.4 He acts in a manner of an ideal gas in a vacuum. Thus, refrigeration is obtained using any conventional thermal cycle, but preferably a Stirling or Carnot cycle. A single phase solution of liquid .sup.3 He at an initial concentration in superfluid .sup.4 He is contained in a first variable volume connected to a second variable volume through a superleak device that enables free passage of .sup.4 He while restricting passage of .sup.3 He. The .sup.3 He is compressed (concentrated) and expanded (diluted) in a phased manner to carry out the selected thermal cycle to remove heat from the heat load for cooling below 1 K.

  1. Religion, migration og integration

    DEFF Research Database (Denmark)

    Borup, Jørn

    2010-01-01

    Sammenhængen mellem religion og integration har de sidste år været genstand for debat. Artiklen kommer ind på begreber og sammenhænge relateret til området (migration, diaspora, assimilation, etnicitet, kultur) og ser på religionens mulige rolle som negativ eller positiv ressource i integrationss......Sammenhængen mellem religion og integration har de sidste år været genstand for debat. Artiklen kommer ind på begreber og sammenhænge relateret til området (migration, diaspora, assimilation, etnicitet, kultur) og ser på religionens mulige rolle som negativ eller positiv ressource i...

  2. Grain boundary migration

    International Nuclear Information System (INIS)

    Dimitrov, O.

    1975-01-01

    Well-established aspects of grain-boundary migration are first briefly reviewed (influences of driving force, temperature, orientation and foreign atoms). Recent developments of the experimental methods and results are then examined, by considering the various driving of resistive forces acting on grain boundaries. Finally, the evolution in the theoretical models of grain-boundary motion is described, on the one hand for ideally pure metals and, on the other hand, in the presence of solute impurity atoms [fr

  3. Ventriculoperitoneal Shunt Migration

    Directory of Open Access Journals (Sweden)

    Justin P Puller

    2017-01-01

    Full Text Available History of present illness: A 40-year-old female presented to our ED with left upper abdominal pain and flank pain. The pain had begun suddenly 2 hours prior when she was reaching into a freezer to get a bag of frozen vegetables. She described the pain as sharp, constant, severe, and worse with movements and breathing. The pain radiated to the left shoulder. On review of systems, the patient had mild dyspnea and nausea. She denied fever, chills, headache, vision changes, vomiting, or urinary symptoms. Her medical history was notable for obstructive sleep apnea, gastroesophageal reflux disease, arthritis, fibromyalgia, depression, obesity, and idiopathic intracranial hypertension. For the latter, she had a VP (ventriculoperitoneal shunt placed 14 years prior to this visit. She had a history of 2 shunt revisions, the most recent 30 days before this ED visit. Significant findings: An immediate post-op abdominal x-ray performed after the patient’s VP shunt revision 30 days prior to this ED visit reveals the VP shunt tip in the mid abdomen. A CT of the abdomen performed on the day of the ED visit reveals the VP shunt tip interposed between the spleen and the diaphragm. Discussion: VP shunts have been reported to migrate to varied locations in the thorax and abdomen. Incidence of abdominal complications of VP shunt placement ranges from 10%-30%, and can include pseudocyst formation, migration, peritonitis, CSF ascites, infection, and viscus perforation. Incidence of distal shunt migration is reported as 10%, and most previously reported cases occurred in pediatric patients.1 A recent retrospective review cited BMI greater than thirty and previous shunt procedure as risk factors for distal shunt migration.2 The patient in the case presented had a BMI of 59 and 3 previous shunt procedures.

  4. Mesoscale Simulations of Pore Migration in a Nuclear Fuel

    International Nuclear Information System (INIS)

    Radhakrishnan, Balasubramaniam; Gorti, Sarma B.

    2010-01-01

    The evolution of pore and grain structure in a nuclear fuel environment is strongly influenced by the local temperature, and the temperature gradient. The evolution of pore and grain structure in an externally imposed temperature gradient is simulated for a hypothetical material using a Potts model approach that allows for porosity migration by mechanisms similar to surface, grain boundary and volume diffusion, as well as the interaction of migrating pores with stationary grain boundaries. First, the migration of a single pore in a single crystal in the presence of the temperature gradient is simulated. Next, the interaction of a pore moving in a temperature gradient with a grain boundary that is perpendicular to the pore migration direction is simulated in order to capture the force exerted by the pore on the grain boundary. The simulations reproduce the expected variation of pore velocity with pore size as well as the variation of the grain boundary force with pore size.

  5. Conservation physiology of animal migration

    Science.gov (United States)

    Lennox, Robert J.; Chapman, Jacqueline M.; Souliere, Christopher M.; Tudorache, Christian; Wikelski, Martin; Metcalfe, Julian D.; Cooke, Steven J.

    2016-01-01

    Migration is a widespread phenomenon among many taxa. This complex behaviour enables animals to exploit many temporally productive and spatially discrete habitats to accrue various fitness benefits (e.g. growth, reproduction, predator avoidance). Human activities and global environmental change represent potential threats to migrating animals (from individuals to species), and research is underway to understand mechanisms that control migration and how migration responds to modern challenges. Focusing on behavioural and physiological aspects of migration can help to provide better understanding, management and conservation of migratory populations. Here, we highlight different physiological, behavioural and biomechanical aspects of animal migration that will help us to understand how migratory animals interact with current and future anthropogenic threats. We are in the early stages of a changing planet, and our understanding of how physiology is linked to the persistence of migratory animals is still developing; therefore, we regard the following questions as being central to the conservation physiology of animal migrations. Will climate change influence the energetic costs of migration? Will shifting temperatures change the annual clocks of migrating animals? Will anthropogenic influences have an effect on orientation during migration? Will increased anthropogenic alteration of migration stopover sites/migration corridors affect the stress physiology of migrating animals? Can physiological knowledge be used to identify strategies for facilitating the movement of animals? Our synthesis reveals that given the inherent challenges of migration, additional stressors derived from altered environments (e.g. climate change, physical habitat alteration, light pollution) or interaction with human infrastructure (e.g. wind or hydrokinetic turbines, dams) or activities (e.g. fisheries) could lead to long-term changes to migratory phenotypes. However, uncertainty remains

  6. Many Faces of Migrations

    Directory of Open Access Journals (Sweden)

    Milica Antić Gaber

    2013-12-01

    We believe that in the present thematic issue we have succeeded in capturing an important part of the modern European research dynamic in the field of migration. In addition to well-known scholars in this field several young authors at the beginning their research careers have been shortlisted for the publication. We are glad of their success as it bodes a vibrancy of this research area in the future. At the same time, we were pleased to receive responses to the invitation from representatives of so many disciplines, and that the number of papers received significantly exceeded the maximum volume of the journal. Recognising and understanding of the many faces of migration are important steps towards the comprehensive knowledge needed to successfully meet the challenges of migration issues today and even more so in the future. It is therefore of utmost importance that researchers find ways of transferring their academic knowledge into practice – to all levels of education, the media, the wider public and, of course, the decision makers in local, national and international institutions. The call also applies to all authors in this issue of the journal.

  7. Migration Process Evolution in Europe

    Directory of Open Access Journals (Sweden)

    Carmen Tudorache

    2006-08-01

    Full Text Available The migration phenomenon has always existed, fluctuating by the historic context, the economic, political, social and demographic disparities between the Central and East European countries and the EU Member States, the interdependencies between the origin and receiving countries and the European integration process evolutions. In the European Union, an integrated and inclusive approach of the migration issue is necessary. But a common policy on migration rests an ambitious objective. A common approach of the economic migration management and the harmonization of the migration policies of the Member States represented a challenge for the European Union and will become urgent in the future, especially due to the demographic ageing.

  8. Migrations in Slovenian geography textbooks

    Directory of Open Access Journals (Sweden)

    Jurij Senegačnik

    2013-12-01

    Full Text Available In Slovenia, the migrations are treated in almost all geographical textbooks for different levels of education. In the textbooks for the elementary school from the sixth to ninth grade, students acquire knowledge of the migrations by the inductive approach. Difficulty level of treatment and quantity of information are increasing by the age level. In the grammar school program a trail of gaining knowledge on migration is deductive. Most attention is dedicated to migrations in general geography textbooks. The textbooks for vocational and technical school programs deal with migrations to a lesser extent and with different approaches.

  9. Welfare payments and other economic determinants of female migration.

    Science.gov (United States)

    Enchautegui, M E

    1997-07-01

    "This article investigates the effects of welfare payments, wages, and unemployment on women's probability of interstate migration [in the United States]. It also investigates if the income attraction of locations varies with recency of labor market experience. Welfare gains increase the probability of interstate migration. Welfare effects are largest for single mothers with small children and stronger among women with no recent labor market experience. The welfare effects, albeit small, are larger than the wage effects. The wage effects are weaker among women with no recent work experience. Ethnic-specific analyses suggest differences in migration behavior among Anglos, African-Americans, and Puerto Ricans." excerpt

  10. The Effects of Return Migration on A Gozitan Village.

    Science.gov (United States)

    King, Russell; Strachan, Alan

    1980-01-01

    A lengthy two-cycle migration pattern is typical of young males on the Maltese island of Gozo. Their typical final return to and reintegration into the natal community impacts the local population, housing development, and the visual appearance of the area. These findings closely parallel prior research results. (SB)

  11. Cell Migration in 1D and 2D Nanofiber Microenvironments.

    Science.gov (United States)

    Estabridis, Horacio M; Jana, Aniket; Nain, Amrinder; Odde, David J

    2018-03-01

    Understanding how cells migrate in fibrous environments is important in wound healing, immune function, and cancer progression. A key question is how fiber orientation and network geometry influence cell movement. Here we describe a quantitative, modeling-based approach toward identifying the mechanisms by which cells migrate in fibrous geometries having well controlled orientation. Specifically, U251 glioblastoma cells were seeded onto non-electrospinning Spinneret based tunable engineering parameters fiber substrates that consist of networks of suspended 400 nm diameter nanofibers. Cells were classified based on the local fiber geometry and cell migration dynamics observed by light microscopy. Cells were found in three distinct geometries: adhering two a single fiber, adhering to two parallel fibers, and adhering to a network of orthogonal fibers. Cells adhering to a single fiber or two parallel fibers can only move in one dimension along the fiber axis, whereas cells on a network of orthogonal fibers can move in two dimensions. We found that cells move faster and more persistently in 1D geometries than in 2D, with cell migration being faster on parallel fibers than on single fibers. To explain these behaviors mechanistically, we simulated cell migration in the three different geometries using a motor-clutch based model for cell traction forces. Using nearly identical parameter sets for each of the three cases, we found that the simulated cells naturally replicated the reduced migration in 2D relative to 1D geometries. In addition, the modestly faster 1D migration on parallel fibers relative to single fibers was captured using a correspondingly modest increase in the number of clutches to reflect increased surface area of adhesion on parallel fibers. Overall, the integrated modeling and experimental analysis shows that cell migration in response to varying fibrous geometries can be explained by a simple mechanical readout of geometry via a motor-clutch mechanism.

  12. The Giant Mottled Eel, Anguilla marmorata, Uses Blue-Shifted Rod Photoreceptors during Upstream Migration

    OpenAIRE

    Wang, Feng-Yu; Fu, Wen-Chun; Wang, I-Li; Yan, Hong Young; Wang, Tzi-Yuan

    2014-01-01

    Catadromous fishes migrate between ocean and freshwater during particular phases of their life cycle. The dramatic environmental changes shape their physiological features, e.g. visual sensitivity, olfactory ability, and salinity tolerance. Anguilla marmorata, a catadromous eel, migrates upstream on dark nights, following the lunar cycle. Such behavior may be correlated with ontogenetic changes in sensory systems. Therefore, this study was designed to identify changes in spectral sensitivity ...

  13. Simultaneous monitoring of the two coupled motors of a single FoF1-ATP synthase by three-color FRET using duty cycle-optimized triple-ALEX

    Science.gov (United States)

    Zarrabi, N.; Ernst, S.; Düser, M. G.; Golovina-Leiker, A.; Becker, W.; Erdmann, R.; Dunn, S. D.; Börsch, M.

    2009-02-01

    FoF1-ATP synthase is the enzyme that provides the 'chemical energy currency' adenosine triphosphate, ATP, for living cells. The formation of ATP is accomplished by a stepwise internal rotation of subunits within the enzyme. Briefly, proton translocation through the membrane-bound Fo part of ATP synthase drives a 10-step rotary motion of the ring of c subunits with respect to the non-rotating subunits a and b. This rotation is transmitted to the γ and ɛ subunits of the F1 sector resulting in 120° steps. In order to unravel this symmetry mismatch we monitor subunit rotation by a single-molecule fluorescence resonance energy transfer (FRET) approach using three fluorophores specifically attached to the enzyme: one attached to the F1 motor, another one to the Fo motor, and the third one to a non-rotating subunit. To reduce photophysical artifacts due to spectral fluctuations of the single fluorophores, a duty cycle-optimized alternating three-laser scheme (DCO-ALEX) has been developed. Simultaneous observation of the stepsizes for both motors allows the detection of reversible elastic deformations between the rotor parts of Fo and F1.

  14. Livelihood Diversification through Migration among a Pastoral People: Contrasting Case Studies of Maasai in Northern Tanzania.

    Science.gov (United States)

    McCabe, J Terrence; Smith, Nicole M; Leslie, Paul W; Telligman, Amy L

    2014-01-01

    This paper brings together over two decades of research concerning the patterns and processes of livelihood diversification through migration among Maasai pastoralists and agro-pastoralists of northern Tanzania. Two case studies, one from the Ngorongoro Conservation Area and the other from the Simanjiro plains, jointly demonstrate the complexity of migration within a single ethnic group. We analyze the relationship between wealth and migration and examine some of the consequences of migration for building herds, expanding cultivation, and influencing political leadership. We further argue that migration in Maasai communities is becoming a cultural norm and not only a response to economic conditions.

  15. Vertical migration of 85Sr, 137Cs and 131I in various arable and undisturbed soils

    International Nuclear Information System (INIS)

    Palagyi, S.; Palagyiova, J.

    2003-01-01

    The vertical migration of 85 Sr, 137 Cs and 131 I in some arable and undisturbed single-contaminated soils was studied by gamma-spectrometry measurements under lysimetric laboratory conditions during irrigation of the soil profiles with wet atmospheric precipitation for about one year, except 131 I. A new simple exponential compartment (box) model was derived, which makes it possible to calculate the migration rate constants and migration rates in the individual soil layers (vertical sections) as well as the total vertical migration rate constants and total vertical migration rates of radionuclides in the bulk soil horizon. The relaxation times of radionuclides in respective soil horizons can also be evaluated. (author)

  16. Japanese migration in contemporary Japan: economic segmentation and interprefectural migration.

    Science.gov (United States)

    Fukurai, H

    1991-01-01

    This paper examines the economic segmentation model in explaining 1985-86 Japanese interregional migration. The analysis takes advantage of statistical graphic techniques to illustrate the following substantive issues of interregional migration: (1) to examine whether economic segmentation significantly influences Japanese regional migration and (2) to explain socioeconomic characteristics of prefectures for both in- and out-migration. Analytic techniques include a latent structural equation (LISREL) methodology and statistical residual mapping. The residual dispersion patterns, for instance, suggest the extent to which socioeconomic and geopolitical variables explain migration differences by showing unique clusters of unexplained residuals. The analysis further points out that extraneous factors such as high residential land values, significant commuting populations, and regional-specific cultures and traditions need to be incorporated in the economic segmentation model in order to assess the extent of the model's reliability in explaining the pattern of interprefectural migration.

  17. Labour migration from Turkey.

    Science.gov (United States)

    Uner, S

    1988-01-01

    This study is concerned with Turkish labor migration to Western Europe. Earlier and recent patterns of labor migration, characteristics of migrants by occupation, area of destination, and by geographical origins are discussed. Economic and demographic consequences of labor migration are also analyzed. It is estimated that Turkey's population will reach 73 million at the year 2000 with the present growth rate of 2.48% annually. Considering the efforts made to slow down the present high fertility rates and assuming that the decrease in labor force participation during 1970-1980 continues, the author concludes that the labor supply will increase with a growth rate of 2% annually for the next 13-15 years. Thus, the labor supply will reach 26.6 million people in the year 2000 from the 1980 level of 17.8 million. Assuming also that the income/employment elasticity of .25 which was observed throughout the period of 1960-1980 will not change until 2000, the annual growth rate of employment may be estimated as 1.5%. Thus, the number of people employed will reach 20 million in the year 1990 and 23.2 million in the year 2000. 8.8 million people will join the labor market as new entrants between 1980 and 2000. Only 6 million people out of 8.8 million will be employed. Thus, in the year 2000, it is estimated that 2.8 million new unemployed people will be added to the already open unemployment figure 1980 census data give the number of unemployed as .6 million people. Adding the 2.8 million new unemployed to this figure totals 3.4 million unemployed in 2000. The State Planning Organization's estimate of labor surplus for 1980 was 2.5 million people. When 2.8 million unemployed people are added to this figure, the labor surplus for the year 2000 reaches 5.3 million people.

  18. ILO - International Migration Programme.

    Science.gov (United States)

    Boudraa, Miriam

    2011-01-01

    In a wide International Context characterised not only by the economical development but also by the social, cultural, political and individual development, we witness more and more to a exchange between the developed and the developing countries, which can be translated especially in the migration of the work force. In theory, all countries are either countries of origin either countries of transit or destination, and they are all responsible for the rights of migrant workers by promoting the rights, by monitoring and by preventing the abusive conditions. The process of migration of the workforce can be divided into three stages: the first coincides with the period prior to departure, the second is represented by the aftermath of the departure and the period of stay in the country of destination, the third stage corresponds to the return in the country of origin. The workers must be protected throughout this process by the international organizations that perform the catalytic role of communication and exchange between countries, for the only purpose of protecting the rights of immigrant and/or immigrants workers. The responsibility for the protection of workers is divided among the various players in the International Labour Organisation. Every country has to apply measures according to the international standards regarding workers' rights, standards that guide the various countries in the formulation and implementation of their policies and legislation. These standards are suggested by International Conventions, the ILO Conventions and other international instruments such as the human rights instrument. There has been a big step forward once the ILO Fundamental Conventions and Conventions on Migrant Workers where implemented and this implementation represented the use of the Guidelines "ILO Multilateral Framework on Labour Migration".

  19. Glacial cycles

    DEFF Research Database (Denmark)

    Kaufmann, R. K.; Juselius, Katarina

    We use a statistical model, the cointegrated vector autoregressive model, to assess the degree to which variations in Earth's orbit and endogenous climate dynamics can be used to simulate glacial cycles during the late Quaternary (390 kyr-present). To do so, we estimate models of varying complexity...... and compare the accuracy of their in-sample simulations. Results indicate that strong statistical associations between endogenous climate variables are not enough for statistical models to reproduce glacial cycles. Rather, changes in solar insolation associated with changes in Earth's orbit are needed...... to simulate glacial cycles accurately. Also, results suggest that non-linear 10 dynamics, threshold effects, and/or free oscillations may not play an overriding role in glacial cycles....

  20. Fuel cycles

    International Nuclear Information System (INIS)

    Hawley, N.J.

    1983-05-01

    AECL publications, from the open literature, on fuels and fuel cycles used in CANDU reactors are listed in this bibliography. The accompanying index is by subject. The bibliography will be brought up to date periodically

  1. Urbanization, Migration, Information

    Directory of Open Access Journals (Sweden)

    Konstantin Lidin

    2016-05-01

    Full Text Available In the contemporary world urbanization becomes a large-scale process. Huge flows of people migrate from poorer districts to the cities with a higher level of consumption. It takes migrants about 15-25 years to give up their traditional ascetic way of life. In this period the ‘new citizens’ try to arrange compact settlements with an archaic way of life, insanitary conditions, high criminogenity and an authoritative local self-government. The processes of formation and decay of the ascetic enclave are viewed through the example of the ‘Shanghai’ trading neighborhood in Irkutsk.

  2. Neuronal Migration and Neuronal Migration Disorder in Cerebral Cortex

    OpenAIRE

    SUN, Xue-Zhi; TAKAHASHI, Sentaro; GUI, Chun; ZHANG, Rui; KOGA, Kazuo; NOUYE, Minoru; MURATA, Yoshiharu

    2002-01-01

    Neuronal cell migration is one of the most significant features during cortical development. After final mitosis, neurons migrate from the ventricular zone into the cortical plate, and then establish neuronal lamina and settle onto the outermost layer, forming an "inside-out" gradient of maturation. Neuronal migration is guided by radial glial fibers and also needs proper receptors, ligands, and other unknown extracellular factors, requests local signaling (e.g. some emitted by the Cajal-Retz...

  3. 24-month fuel cycles

    International Nuclear Information System (INIS)

    Rosenstein, R.G.; Sipes, D.E.; Beall, R.H.; Donovan, E.J.

    1986-01-01

    Twenty-four month reload cycles can potentially lessen total power generation costs. While 24-month cores increase purchased fuel costs, the longer cycles reduce the number of refueling outages and thus enhance plant availability; men-rem exposure to site personnel and other costs associated with reload core design and licensing are also reduced. At dual unit sites an operational advantage can be realized by refueling each plant alternately on a 1-year offset basis. This results in a single outage per site per year which can be scheduled for off-peak periods or when replacement power costs are low

  4. Multi-cellular logistics of collective cell migration.

    Directory of Open Access Journals (Sweden)

    Masataka Yamao

    Full Text Available During development, the formation of biological networks (such as organs and neuronal networks is controlled by multicellular transportation phenomena based on cell migration. In multi-cellular systems, cellular locomotion is restricted by physical interactions with other cells in a crowded space, similar to passengers pushing others out of their way on a packed train. The motion of individual cells is intrinsically stochastic and may be viewed as a type of random walk. However, this walk takes place in a noisy environment because the cell interacts with its randomly moving neighbors. Despite this randomness and complexity, development is highly orchestrated and precisely regulated, following genetic (and even epigenetic blueprints. Although individual cell migration has long been studied, the manner in which stochasticity affects multi-cellular transportation within the precisely controlled process of development remains largely unknown. To explore the general principles underlying multicellular migration, we focus on the migration of neural crest cells, which migrate collectively and form streams. We introduce a mechanical model of multi-cellular migration. Simulations based on the model show that the migration mode depends on the relative strengths of the noise from migratory and non-migratory cells. Strong noise from migratory cells and weak noise from surrounding cells causes "collective migration," whereas strong noise from non-migratory cells causes "dispersive migration." Moreover, our theoretical analyses reveal that migratory cells attract each other over long distances, even without direct mechanical contacts. This effective interaction depends on the stochasticity of the migratory and non-migratory cells. On the basis of these findings, we propose that stochastic behavior at the single-cell level works effectively and precisely to achieve collective migration in multi-cellular systems.

  5. Network migration for printers

    CERN Multimedia

    2016-01-01

    Further to the recent General Purpose (office) Network reorganisation (as announced in the Bulletin - see here), please note that the majority of print devices will be automatically migrated to the new network IP address range on Tuesday 27 September.   This change should be transparent for these devices and therefore end-users, provided you have installed the printers from the Print Service website. A small number of devices will require manual intervention from the Printer Support team in order to migrate correctly. These devices will not change their IP address until the manual intervention, which will be carried out before Monday 3rd October. However, if you have mistakenly connected directly to the printer’s IP address, then your printing will be affected – please uninstall the printer (for help, see: KB3785), and re-install it from the Print Service website (or follow instructions for visitor machines). Please do this as soon as possible in order to avoid printing issues, t...

  6. Transtracheal single-point stent fixation in posttracheotomy tracheomalacia under cone-beam computer tomography guidance by transmural suturing with the Berci needle - a perspective on a new tool to avoid stent migration of Dumon stents.

    Science.gov (United States)

    Hohenforst-Schmidt, Wolfgang; Linsmeier, Bernd; Zarogoulidis, Paul; Freitag, Lutz; Darwiche, Kaid; Browning, Robert; Turner, J Francis; Huang, Haidong; Li, Qiang; Vogl, Thomas; Zarogoulidis, Konstantinos; Brachmann, Johannes; Rittger, Harald

    2015-01-01

    Tracheomalacia or tracheobronchomalacia (TM or TBM) is a common problem especially for elderly patients often unfit for surgical techniques. Several surgical or minimally invasive techniques have already been described. Stenting is one option but in general long-time stenting is accompanied by a high complication rate. Stent removal is more difficult in case of self-expandable nitinol stents or metallic stents in general in comparison to silicone stents. The main disadvantage of silicone stents in comparison to uncovered metallic stents is migration and plugging. We compared the operation time and in particular the duration of a sufficient Dumon stent fixation with different techniques in a patient with severe posttracheotomy TM and strongly reduced mobility of the vocal cords due to Parkinson's disease. The combined approach with simultaneous Dumon stenting and endoluminal transtracheal externalized suture under cone-beam computer tomography guidance with the Berci needle was by far the fastest approach compared to a (not performed) surgical intervention, or even purely endoluminal suturing through the rigid bronchoscope. The duration of the endoluminal transtracheal externalized suture was between 5 minutes and 9 minutes with the Berci needle; the pure endoluminal approach needed 51 minutes. The alternative of tracheobronchoplasty was refused by the patient. In general, 180 minutes for this surgical approach is calculated. The costs of the different approaches are supposed to vary widely due to the fact that in Germany 1 minute in an operation room costs on average approximately 50-60€ inclusive of taxes. In our own hospital (tertiary level), it is nearly 30€ per minute in an operation room for a surgical approach. Calculating an additional 15 minutes for patient preparation and transfer to wake-up room, therefore a total duration inside the investigation room of 30 minutes, the cost per flexible bronchoscopy is per minute on average less than 6€. Although

  7. Transtracheal single-point stent fixation in posttracheotomy tracheomalacia under cone-beam computer tomography guidance by transmural suturing with the Berci needle – a perspective on a new tool to avoid stent migration of Dumon stents

    Science.gov (United States)

    Hohenforst-Schmidt, Wolfgang; Linsmeier, Bernd; Zarogoulidis, Paul; Freitag, Lutz; Darwiche, Kaid; Browning, Robert; Turner, J Francis; Huang, Haidong; Li, Qiang; Vogl, Thomas; Zarogoulidis, Konstantinos; Brachmann, Johannes; Rittger, Harald

    2015-01-01

    Tracheomalacia or tracheobronchomalacia (TM or TBM) is a common problem especially for elderly patients often unfit for surgical techniques. Several surgical or minimally invasive techniques have already been described. Stenting is one option but in general long-time stenting is accompanied by a high complication rate. Stent removal is more difficult in case of self-expandable nitinol stents or metallic stents in general in comparison to silicone stents. The main disadvantage of silicone stents in comparison to uncovered metallic stents is migration and plugging. We compared the operation time and in particular the duration of a sufficient Dumon stent fixation with different techniques in a patient with severe posttracheotomy TM and strongly reduced mobility of the vocal cords due to Parkinson’s disease. The combined approach with simultaneous Dumon stenting and endoluminal transtracheal externalized suture under cone-beam computer tomography guidance with the Berci needle was by far the fastest approach compared to a (not performed) surgical intervention, or even purely endoluminal suturing through the rigid bronchoscope. The duration of the endoluminal transtracheal externalized suture was between 5 minutes and 9 minutes with the Berci needle; the pure endoluminal approach needed 51 minutes. The alternative of tracheobronchoplasty was refused by the patient. In general, 180 minutes for this surgical approach is calculated. The costs of the different approaches are supposed to vary widely due to the fact that in Germany 1 minute in an operation room costs on average approximately 50–60€ inclusive of taxes. In our own hospital (tertiary level), it is nearly 30€ per minute in an operation room for a surgical approach. Calculating an additional 15 minutes for patient preparation and transfer to wake-up room, therefore a total duration inside the investigation room of 30 minutes, the cost per flexible bronchoscopy is per minute on average less than 6

  8. MIGRATION AND ITS ENVIROMENTAL EFFECTS

    OpenAIRE

    Rashid SAEED; Rana NADIR IDREES; Humna IJAZ; Marriam FURQANI; Raziya NADEEM

    2012-01-01

    Migration can be ongoing shifting of a particular person from one location to another. The reason of shifting depends on selected thought deficiency, shock, difficulties, hopes, enthusiasm. Case study ended up recognizing the extent to which in turn migration can be relying on the specifics especially natural environment. This particular document expects to research the actual linkages between the atmosphere as well as migration using secondary data. Lots of investigation may be completed wit...

  9. Nordic Migration and Integration Research

    OpenAIRE

    Pyrhönen, Niko; Martikainen, Tuomas; Leinonen, Johanna

    2017-01-01

    EXECUTIVE SUMMARY Migration and integration are currently highly contentious topics in political, public and scientific arenas, and will remain so in the near future. However, many common migration-related prejudices and inefficien¬cies in the integration of the migrant population are due to the lack of sound, tested and accessible scientific research. Therefore, the study of migration – by developing basic research and by properly resourcing novel methodological approaches and interventions ...

  10. The challenges of managing migration

    Energy Technology Data Exchange (ETDEWEB)

    Tacoli, Cecilia

    2005-10-15

    Migration and urbanisation are driven by economic growth and social change, but also by deepening inequalities. Managing migration should not be equated with curbing it, as this inevitably reduces migrants' rights. But managing population movement whilst respecting the rights of migrants and nonmigrants, supporting the contribution of migration to poverty reduction and economic growth in sending and receiving areas and reducing the human and material costs of movement means that fundamental challenges need to be addressed.

  11. Countering inbreeding with migration 1. Migration from unrelated ...

    African Journals Online (AJOL)

    Ret:ieved 6 Octoher 1991; ut:cepted I8 Mur- 1995. The eff'ect of migration on inbreeding is moclelled fbr small populations with immigrants from a large unrelated population. Different migration rates and numbers fbr the two sexes are assumed, and a general recursion equation for inbreeding progress derived, which can ...

  12. Transtracheal single-point stent fixation in posttracheotomy tracheomalacia under cone-beam computer tomography guidance by transmural suturing with the Berci needle – a perspective on a new tool to avoid stent migration of Dumon stents

    Directory of Open Access Journals (Sweden)

    Hohenforst-Schmidt W

    2015-05-01

    Full Text Available Wolfgang Hohenforst-Schmidt,1,9 Bernd Linsmeier,2 Paul Zarogoulidis,3 Lutz Freitag,4 Kaid Darwiche,4 Robert Browning,5 J Francis Turner,6 Haidong Huang,7 Qiang Li,7 Thomas Vogl,8 Konstantinos Zarogoulidis,3 Johannes Brachmann,9 Harald Rittger1 1Medical Clinic I, “Fuerth” Hospital, University of Erlangen, Fuerth, Germany; 2Department of Thoracic Surgery, Medinos Clinic Sonneberg, Sonnerberg, Germany; 3Pulmonary Department-Oncology Unit, “G. Papanikolaou” General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece; 4Department of Interventional Pneumology, Ruhrlandklinik, University Hospital Essen, University of Essen-Duisburg, Tueschener Weg, Essen, Germany; 5Pulmonary and Critical Care Medicine, Interventional Pulmonology, National Naval Medical Center, Walter Reed Army Medical Center, Bethesda, MD, USA; 6Division of Interventional Pulmonology and Medical Oncology, Cancer Treatment Centers of America, Western Regional Medical Center, Goodyear, AZ, USA; 7Department of Respiratory Diseases Shanghai Hospital, II Military University Hospital, Shanghai, People’s Republic of China; 8Department of Diagnostic and Interventional Radiology, Goethe University of Frankfurt, Frankfurt, Germany; 9II Medical Clinic, “Coburg” Hospital, University of Wuerzburg, Coburg, GermanyAbstract: Tracheomalacia or tracheobronchomalacia (TM or TBM is a common problem especially for elderly patients often unfit for surgical techniques. Several surgical or minimally invasive techniques have already been described. Stenting is one option but in general long-time stenting is accompanied by a high complication rate. Stent removal is more difficult in case of self-expandable nitinol stents or metallic stents in general in comparison to silicone stents. The main disadvantage of silicone stents in comparison to uncovered metallic stents is migration and plugging. We compared the operation time and in particular the duration of a sufficient Dumon stent

  13. The effect of short-duration sub-maximal cycling on balance in single-limb stance in patients with anterior cruciate ligament injury: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Roberts David

    2004-11-01

    Full Text Available Abstract Background It has previously been shown that an anterior cruciate ligament (ACL injury may lead to impaired postural control, and that the ability to maintain postural control is decreased by fatigue in healthy subjects. To our knowledge, no studies have reported the effect of fatigue on postural control in subjects with ACL injury. This study was aimed at examining the effect of fatigue on balance in single-limb stance in subjects with ACL injury, and to compare the effects, and the ability to maintain balance, with that of a control group of uninjured subjects. Methods Thirty-six patients with unilateral, non-operated, non-acute ACL injury, and 24 uninjured subjects were examined with stabilometry before (pre-exercise and immediately after (post-exercise short-duration, sub-maximal cycling. In addition, the post-exercise measurements were compared, to evaluate the instantaneous ability to maintain balance and any possible recovery. The amplitude and average speed of center of pressure movements were registered in the frontal and sagittal planes. The paired t-test was used for the intra-group comparisons, and the independent t-test for the inter-group comparisons, with Bonferroni correction for multiple comparisons. Results No differences were found in the effects of exercise between the patients and the controls. Analysis of the post-exercise measurements revealed greater effects or a tendency towards greater effects on the injured leg than in the control group. The average speed was lower among the patients than in the control group. Conclusions The results of the present study showed no differences in the effects of exercise between the patients and the controls. However, the patients seemed to react differently regarding ability to maintain balance in single-limb stance directly after exercise than the control group. The lower average speed among the patients may be an expression of different neuromuscular adaptive strategies than

  14. The pulsed migration of hydrocarbons across inactive faults

    Directory of Open Access Journals (Sweden)

    S. D. Harris

    1999-01-01

    Full Text Available Geological fault zones are usually assumed to influence hydrocarbon migration either as high permeability zones which allow enhanced along- or across-fault flow or as barriers to the flow. An additional important migration process inducing along- or across-fault migration can be associated with dynamic pressure gradients. Such pressure gradients can be created by earthquake activity and are suggested here to allow migration along or across inactive faults which 'feel' the quake-related pressure changes; i.e. the migration barriers can be removed on inactive faults when activity takes place on an adjacent fault. In other words, a seal is viewed as a temporary retardation barrier which leaks when a fault related fluid pressure event enhances the buoyancy force and allows the entry pressure to be exceeded. This is in contrast to the usual model where a seal leaks because an increase in hydrocarbon column height raises the buoyancy force above the entry pressure of the fault rock. Under the new model hydrocarbons may migrate across the inactive fault zone for some time period during the earthquake cycle. Numerical models of this process are presented to demonstrate the impact of this mechanism and its role in filling traps bounded by sealed faults.

  15. Migration and regional inequality

    DEFF Research Database (Denmark)

    Peng, Lianqing; Swider, Sarah

    2017-01-01

    Scholars studying economic inequality in China have maintained that regional inequality and economic divergence across provinces have steadily increased over the past 30 years. New studies have shown that this trend is a statistical aberration; calculations show that instead of quickly and sharply...... rising, regional inequality has actually decreased, and most recently, remained stable. Our study suggests that China’s unique migratory regime is crucial to understanding these findings. We conduct a counterfactual simulation to demonstrate how migration and remittances have mitigated income inequality...... across provinces in order to show that without these processes, we would have seen more of a rise in interprovincial income inequality. We conclude by arguing that inequality in China is still increasing, but it is changing and becoming less place-based. As regional inequality decreases, there are signs...

  16. Tracking migrating birds

    DEFF Research Database (Denmark)

    Willemoes, Mikkel

    habitats with those in rural habitats. Some species have decreased the frequency of migrants and migration distance in urban environments, and others have not. The other manuscript describes the small scale movements of three different Palaearctic migrants during winter in Africa in a farmland habitat....... In another species, environmental conditions are not a good predictor of movements, and possibly effects of timing constraints or food type play a role. Two manuscripts focus on the effects of human-induced habitat alterations on migratory behaviour. One compares the movements of partial migrants in urban...... and a forest reserve. In the degraded habitat all species used more space, although the consequence on bird density is less clear. Two manuscripts relate the migratory movements of a long-distance migrant with models of navigation. One compares model predictions obtained by simulation with actual movements...

  17. Making Migration Meaningful

    DEFF Research Database (Denmark)

    Benwell, Ann Fenger

    2013-01-01

    a way to escape family patriarchy and conformity, and can contribute to loss, hardship, and uncertainty for family members left behind. Further, mobility provides opportunities and a means to escape the stigma of ‘laziness’ culturally associated with poverty and immobility. Postsocialist separation has...... of absence by migrant family members, as both men and women are culturally permitted to be separate from their families. Migration is understood to contribute to prosperity, and separations contribute to generate growth and hishig (good fortune) for the good of the family. However, such mobility is also......Mongolia has experienced two decades since the demise of the Soviet Union and has implemented strategies to strengthen its economy and its democratic practices. Transitions from being a nomadic society to a Soviet satellite state and onwards to liberal democracy have greatly impacted family life...

  18. Nightly Test system migration

    CERN Document Server

    Win-Lime, Kevin

    2013-01-01

    The summer student program allows students to participate to the Cern adventure. They can follow several interesting lectures about particle science and participate to the experiment work. As a summer student, I had worked for LHCb experiment. LHCb uses a lot of software to analyze its data. All this software is organized in packages and projects. They are built and tested during the night using an automated system and the results are displayed on a web interface. Actually, LHCb is changing this system. It is looking for a replacement candidate. So I was charged to unify some internal interfaces to permit a swift migration. In this document, I will describe shortly the system used by LHCb, then I will explain what I have done in detail.

  19. Migration: the trends converge.

    Science.gov (United States)

    1985-09-01

    Formerly, Australia, New Zealand, Canada, and the US have served as permanent destinations for immigrants, while Europe's migrants have moved to more northerly countries to work for a time and then returned home. From 1973-1975 Europe's recruitment of foreign workers virtually ended, although family reunion for those immigrants allowed in was encouraged. Problems resulting from this new settlement migration include low paying jobs for immigrant women, high unemployment, and inadequate education for immigrant children. Illegal migrants from Latin America and the Caribbean enter the US and Canada each year while illegal North African immigrants enter Italy, Spain, and Greece. North America, Australia, and Europe have all received political refugees from Asia and Latin America. Increasingly, these foreigners compete in the labor market rather than simply fill jobs the native workers do not want. All the receiving countries have similar policy priorities: 1) more effective ways for controlling and monitoring inflows and checking illegal immigration; 2) encouraging normal living patterns and accepting refugees; and 3) integrating permanent migrants into the host country. Europe's public immigration encouragement prior to the first oil shock, has left some countries with a labor force that is reluctant to return home. It is unlikely that Europe will welcome foreign labor again in this decade, since unemployment among young people and women is high and family reunion programs may still bring in many immigrants. Less immigration pattern change will probably occur in North America, Australia, and New Zealand since these countries' populations are still growing and wages are more flexible. Immigration, regulated by policy, and emigration, determined by market forces, now are working in the same direction and will likely reduce future migration flows.

  20. Structural-equation models of migration: an example from the Upper Midwest USA.

    Science.gov (United States)

    Cadwallader, M

    1985-01-01

    "To date, most migration models have been specified in terms of a single equation, whereby a set of regional characteristics are used to predict migration rates for various kinds of spatial units. These models are inadequate in at least two respects. First, they omit any causal links between the explanatory variables, thus ignoring indirect effects between these variables and migration. Second, they ignore the possibility of reciprocal causation, or feedback effects, between migration and the explanatory variables...." The author uses data for State Economic Areas to construct a path model and simultaneous-equation model to identify both indirect and feedback effects on migration in the Upper Midwestern United States. "On the basis of the path model, it is suggested that the direct effects of many variables on migration are at least partially offset by the indirect effects, whereas the simultaneous-equation model emphasizes the reciprocal relationship between income and migration." excerpt

  1. Coordination cycles

    Czech Academy of Sciences Publication Activity Database

    Steiner, Jakub

    -, č. 274 (2005), s. 1-26 ISSN 1211-3298 Institutional research plan: CEZ:AV0Z70850503 Keywords : coordination * crises * cycles and fluctuations Subject RIV: AH - Economics http://www.cerge-ei.cz/pdf/wp/Wp274.pdf

  2. Happy Cycling

    DEFF Research Database (Denmark)

    Geert Jensen, Birgitte; Nielsen, Tom

    2013-01-01

    og Interaktions Design, Aarhus Universitet under opgave teamet: ”Happy Cycling City – Aarhus”. Udfordringen i studieopgaven var at vise nye attraktive løsningsmuligheder i forhold til cyklens og cyklismens integration i byrum samt at påpege relationen mellem design og overordnede diskussioner af...

  3. Coordination cycles

    Czech Academy of Sciences Publication Activity Database

    Steiner, Jakub

    2008-01-01

    Roč. 63, č. 1 (2008), s. 308-327 ISSN 0899-8256 Institutional research plan: CEZ:AV0Z70850503 Keywords : global games * coordination * crises * cycles and fluctuations Subject RIV: AH - Economics Impact factor: 1.333, year: 2008

  4. Challenged by migration: Europe's options

    NARCIS (Netherlands)

    Constant, Amelie F.; Zimmermann, Klaus F.

    2017-01-01

    This paper examines the migration and labour mobility in the European Union and elaborates on their importance for the existence of the EU. Against all measures of success, the current public debate seems to suggest that the political consensus that migration is beneficial is broken. This comes with

  5. Radionuclide migration studies in soil

    International Nuclear Information System (INIS)

    Marumo, J.T.

    1989-01-01

    In this work a brief description about retention and migration parameters of radionuclides in soil, including main methods to determine the distribution coefficient (K) are given. Some of several factors that can act on the migration are also mentioned. (author) [pt

  6. South-South Migration and Remittances

    OpenAIRE

    Ratha, Dilip; Shaw, William

    2007-01-01

    South-South Migration and Remittances reports on preliminary results from an ongoing effort to improve data on bilateral migration stocks. It sets out some working hypotheses on the determinants and socioeconomic implications of South-South migration. Contrary to popular perception that migration is mostly a South-North phenomenon, South-South migration is large. Available data from nation...

  7. Optimum gas turbine cycle for combined cycle power plant

    International Nuclear Information System (INIS)

    Polyzakis, A.L.; Koroneos, C.; Xydis, G.

    2008-01-01

    The gas turbine based power plant is characterized by its relatively low capital cost compared with the steam power plant. It has environmental advantages and short construction lead time. However, conventional industrial engines have lower efficiencies, especially at part load. One of the technologies adopted nowadays for efficiency improvement is the 'combined cycle'. The combined cycle technology is now well established and offers superior efficiency to any of the competing gas turbine based systems that are likely to be available in the medium term for large scale power generation applications. This paper has as objective the optimization of a combined cycle power plant describing and comparing four different gas turbine cycles: simple cycle, intercooled cycle, reheated cycle and intercooled and reheated cycle. The proposed combined cycle plant would produce 300 MW of power (200 MW from the gas turbine and 100 MW from the steam turbine). The results showed that the reheated gas turbine is the most desirable overall, mainly because of its high turbine exhaust gas temperature and resulting high thermal efficiency of the bottoming steam cycle. The optimal gas turbine (GT) cycle will lead to a more efficient combined cycle power plant (CCPP), and this will result in great savings. The initial approach adopted is to investigate independently the four theoretically possible configurations of the gas plant. On the basis of combining these with a single pressure Rankine cycle, the optimum gas scheme is found. Once the gas turbine is selected, the next step is to investigate the impact of the steam cycle design and parameters on the overall performance of the plant, in order to choose the combined cycle offering the best fit with the objectives of the work as depicted above. Each alterative cycle was studied, aiming to find the best option from the standpoint of overall efficiency, installation and operational costs, maintainability and reliability for a combined power

  8. Gender Differences in Stressors Related to Migration and Acculturation in Patients with Psychiatric Disorders and Turkish Migration Background.

    Science.gov (United States)

    Müller, Matthias Johannes; Koch, Eckhardt

    2017-06-01

    Migration, acculturation, and psychiatric disorders may cause stress and adaptation processes differently in men and women, but empirical research is scarce. In a retrospective study n = 62 Turkish migrants and n = 62 native German inpatients with depressive or anxiety disorders, matched for age, gender, and diagnoses, were compared using a 10-item instrument for the assessment of migration- and acculturation related stressors (MIGSTR10). Gender differences in the prevalence of stressors and in the total sum of stressors were calculated and compared between migrants and indigenous patients. Results showed a higher global stress level in migrants and in women than in men with migration background. Regarding single stressors, the perceived loss of status was significantly more prevalent and more pronounced in men than in women (P stress should be taken into account in migration and acculturation research.

  9. Innovative Visualizations Shed Light on Avian Nocturnal Migration.

    Directory of Open Access Journals (Sweden)

    Judy Shamoun-Baranes

    Full Text Available Globally, billions of flying animals undergo seasonal migrations, many of which occur at night. The temporal and spatial scales at which migrations occur and our inability to directly observe these nocturnal movements makes monitoring and characterizing this critical period in migratory animals' life cycles difficult. Remote sensing, therefore, has played an important role in our understanding of large-scale nocturnal bird migrations. Weather surveillance radar networks in Europe and North America have great potential for long-term low-cost monitoring of bird migration at scales that have previously been impossible to achieve. Such long-term monitoring, however, poses a number of challenges for the ornithological and ecological communities: how does one take advantage of this vast data resource, integrate information across multiple sensors and large spatial and temporal scales, and visually represent the data for interpretation and dissemination, considering the dynamic nature of migration? We assembled an interdisciplinary team of ecologists, meteorologists, computer scientists, and graphic designers to develop two different flow visualizations, which are interactive and open source, in order to create novel representations of broad-front nocturnal bird migration to address a primary impediment to long-term, large-scale nocturnal migration monitoring. We have applied these visualization techniques to mass bird migration events recorded by two different weather surveillance radar networks covering regions in Europe and North America. These applications show the flexibility and portability of such an approach. The visualizations provide an intuitive representation of the scale and dynamics of these complex systems, are easily accessible for a broad interest group, and are biologically insightful. Additionally, they facilitate fundamental ecological research, conservation, mitigation of human-wildlife conflicts, improvement of meteorological

  10. Measuring International Migration in Azerbaijan

    Directory of Open Access Journals (Sweden)

    Serhat Yüksel

    2018-01-01

    Full Text Available International migration significantly affects economic, social, cultural, and political factors of the country. Owing to this situation, it can be said that the reasons of international migration should be analyzed in order to control this problem. The purpose of this study is to determine the influencing factors of international migration in Azerbaijan. In this scope, annual data of 11 explanatory variables for the period of 1995–2015 was analyzed via Multivariate Adaptive Regression Splines (MARS method. According to the results of this analysis, it was identified that people prefer to move other countries in case of high unemployment rates. In addition, the results of the study show that population growth and high mortality rate increases the migration level. While considering these results, it was recommended that Azerbaijan should focus on these aspects to control international migration problem.

  11. Groundwater migration of radionuclides at Fermilab

    International Nuclear Information System (INIS)

    Malensek, A.J.; Wehmann, A.A.; Elwyn, A.J.; Moss, K.J.; Kesich, P.M.

    1993-01-01

    The simple Single Resident Well (SRW) Model has been used to calculate groundwater movement since Fermilab's inception. A new Concentration Model is proposed which is more realistic and takes advantage of computer modeling that has been developed for the siting of landfills. Site geologic and hydrologic data were given to a consultant who made the migration calculations from an initial concentration that was based upon the existing knowledge of the radioactivity leached out of the soil. The various components of the new Model are discussed, and numerical examples are given and compared with DOE/EPA limits

  12. Diverging patterns with endogenous labor migration.

    Science.gov (United States)

    Reichlin, P; Rustichini, A

    1998-05-05

    "The standard neoclassical model cannot explain persistent migration flows and lack of cross-country convergence when capital and labor are mobile. Here we present a model where both phenomena may take place.... Our model is based on the Arrow-Romer approach to endogenous growth theory. We single out the importance of a (however weak) scale effect from the size of the workforce.... The main conclusion of this simple model is that lack of convergence, or even divergence, among countries is possible, even with perfect capital mobility and labor mobility." excerpt

  13. Robotic Patterning a Superhydrophobic Surface for Collective Cell Migration Screening.

    Science.gov (United States)

    Pang, Yonggang; Yang, Jing; Hui, Zhixin; Grottkau, Brian E

    2018-04-01

    Collective cell migration, in which cells migrate as a group, is fundamental in many biological and pathological processes. There is increasing interest in studying the collective cell migration in high throughput. Cell scratching, insertion blocker, and gel-dissolving techniques are some methodologies used previously. However, these methods have the drawbacks of cell damage, substrate surface alteration, limitation in medium exchange, and solvent interference. The superhydrophobic surface, on which the water contact angle is greater than 150 degrees, has been recently utilized to generate patterned arrays. Independent cell culture areas can be generated on a substrate that functions the same as a conventional multiple well plate. However, so far there has been no report on superhydrophobic patterning for the study of cell migration. In this study, we report on the successful development of a robotically patterned superhydrophobic array for studying collective cell migration in high throughput. The array was developed on a rectangular single-well cell culture plate consisting of hydrophilic flat microwells separated by the superhydrophobic surface. The manufacturing process is robotic and includes patterning discrete protective masks to the substrate using 3D printing, robotic spray coating of silica nanoparticles, robotic mask removal, robotic mini silicone blocker patterning, automatic cell seeding, and liquid handling. Compared with a standard 96-well plate, our system increases the throughput by 2.25-fold and generates a cell-free area in each well non-destructively. Our system also demonstrates higher efficiency than conventional way of liquid handling using microwell plates, and shorter processing time than manual operating in migration assays. The superhydrophobic surface had no negative impact on cell viability. Using our system, we studied the collective migration of human umbilical vein endothelial cells and cancer cells using assays of endpoint

  14. Uniform Page Migration Problem in Euclidean Space

    Directory of Open Access Journals (Sweden)

    Amanj Khorramian

    2016-08-01

    Full Text Available The page migration problem in Euclidean space is revisited. In this problem, online requests occur at any location to access a single page located at a server. Every request must be served, and the server has the choice to migrate from its current location to a new location in space. Each service costs the Euclidean distance between the server and request. A migration costs the distance between the former and the new server location, multiplied by the page size. We study the problem in the uniform model, in which the page has size D = 1 . All request locations are not known in advance; however, they are sequentially presented in an online fashion. We design a 2.75 -competitive online algorithm that improves the current best upper bound for the problem with the unit page size. We also provide a lower bound of 2.732 for our algorithm. It was already known that 2.5 is a lower bound for this problem.

  15. Migrating and herniating hydatid cysts

    International Nuclear Information System (INIS)

    Koc, Zafer; Ezer, Ali

    2008-01-01

    Objective: To present the prevalence and imaging findings of patients with hydatid disease (HD) showing features of migration or herniation of the hydatid cysts (HCs) and underline the clinical significance of this condition. Materials and methods: Between May 2003 and June 2006, 212 patients with HD were diagnosed by abdomen and/or thorax CT, searched for migrating or herniating HC. Imaging findings of 7 patients (5 women, 2 men with an age range of 19-63 years; mean ± S.D., 44 ± 19 years) with HD showing transdiaphragmatic migration (6 subjects) or femoral herniation (1 subject) were evaluated. Diagnosis of all the patients were established by pathologic examination and migration or herniation was confirmed by surgery in all patients. Results: Liver HD were identified in 169 (79.7%) of 212 patients with HD. Transdiaphragmatic migration of HCs were identified in 6 (3.5%) of the 169 patients with liver HD. In one patient, femoral herniation of the retroperitoneal HC into the proximal anterior thigh was identified. All of these seven patients exhibiting migration or herniation of HCs had active HCs including 'daughter cysts'. Two patients had previous surgery because of liver HD and any supradiaphragmatic lesion was not noted before operation. Findings of migration or herniation were confirmed by surgery. Conclusion: Active HCs may show migration or herniation due to pressure difference between the anatomic cavities, and in some of the patients, by contribution of gravity. Previous surgery may be a complementary factor for migration as seen in two of our patients. The possibility of migration or herniation in patients with HD should be considered before surgery

  16. Current Migration Movements in Europe

    Directory of Open Access Journals (Sweden)

    Jelena Zlatković Winter

    2004-09-01

    Full Text Available After a brief historical review of migrations in Europe, the paper focuses on current migration trends and their consequences. At the end of the 1950s, Western Europe began to recruit labour from several Mediterranean countries – Italy, Spain, Portugal and former Yugoslavia, and later from Morocco, Algeria, Tunisia and Turkey. Some countries, such as France, Great Britain and the Netherlands, recruited also workers from their former colonies. In 1970 Germany had the highest absolute number of foreigners, followed by France, and then Switzerland and Belgium. The total number of immigrants in Western Europe was twelve million. During the 1970s mass recruitment of foreign workers was abandoned, and only the arrival of their family members was permitted, which led to family reunification in the countries of employment. Europe closed its borders, with the result that clandestine migration increased. The year 1989 was a turning point in the history of international migrations. The political changes in Central and Eastern Europe brought about mass migration to the West, which culminated in the so-called “mass movement of 1989–1990”. The arrival of ethnic Germans in Germany, migration inside and outside of the territory of the former Soviet Union, an increase in the number of asylum seekers and displaced persons, due to armed conflicts, are – according to the author – the main traits of current migration. The main part of the paper discusses the causes and effects of this mass wave, as well as trends in labour migration, which is still present. The second part of the paper, after presenting a typology of migrations, deals with the complex processes that brought about the formation of new communities and led to the phenomenon of new ethnic minorities and to corresponding migration policies in Western European countries that had to address these issues.

  17. Absence of correlation between hepatic function and characteristics of migrating motor complexes in the gastrointestinal tract

    DEFF Research Database (Denmark)

    Qvist, N; Oster-Jørgensen, E; Mortensen, P

    1995-01-01

    BACKGROUND: Cyclic changes in gallbladder filling and emptying during the migrating motor complex (MMC) cycle have been demonstrated by scintigraphy. However, a possible cyclic change in the hepatic function and handling of the pharmacologic agents used for scintigraphy during the MMC cycle could...

  18. Understanding Single Adulthood.

    Science.gov (United States)

    Stein, Peter J.

    The life styles and life chances of the unmarried include elements of choices. Singles may be grouped and characterized according to whether their status may be considered stable or temporary. A life cycle, or continuum model of singlehood is reviewed, including its different factors, or phases. A new model for singles is proposed--a life spiral…

  19. Fuel cycle

    International Nuclear Information System (INIS)

    Bahm, W.

    1989-01-01

    The situation of the nuclear fuel cycle for LWR type reactors in France and in the Federal Republic of Germany was presented in 14 lectures with the aim to compare the state-of-the-art in both countries. In addition to the momentarily changing fuilds of fuel element development and fueling strategies, the situation of reprocessing, made interesting by some recent developmnts, was portrayed and differences in ultimate waste disposal elucidated. (orig.) [de

  20. The extra mile: Ungulate migration distance alters the use of seasonal range and exposure to anthropogenic risk

    Science.gov (United States)

    Sawyer, Hall; Middleton, Arthur D.; Hayes, Matthew M.; Kauffman, Matthew J.; Monteith, Kevin L.

    2016-01-01

    Partial migration occurs across a variety of taxa and has important ecological and evolutionary consequences. Among ungulates, studies of partially migratory populations have allowed researchers to compare and contrast performance metrics of migrants versus residents and examine how environmental factors influence the relative abundance of each. Such studies tend to characterize animals discretely as either migratory or resident, but we suggest that variable migration distances within migratory herds are an important and overlooked form of population structure, with potential consequences for animal fitness. We examined whether the variation in individual migration distances (20–264 km) within a single wintering population of mule deer (Odocoileus hemionus) was associated with several critical behavioral attributes of migration, including timing of migration, time allocation to seasonal ranges, and exposure to anthropogenic mortality risks. Both the timing of migration and the amount of time animals allocated to seasonal ranges varied with migration distance. Animals migrating long distances (150–250 km) initiated spring migration more than three weeks before than those migrating moderate (50–150 km) or short distances (forage and effectively increase carrying capacity. Clear differences in winter residency, migration duration, and risk of anthropogenic mortality among short-, moderate-, and long-distance migrants suggest fitness trade-offs may exist among migratory segments of the population. Future studies of partial migration may benefit from expanding comparisons of residents and migrants, to consider how variable migration distances of migrants may influence the costs and benefits of migration.

  1. Geochemistry and radionuclide migration

    International Nuclear Information System (INIS)

    Isherwood, D.

    1978-01-01

    Theoretically, the geochemical barrier can provide a major line of defense in protecting the biosphere from the hazards of nuclear waste. The most likely processes involved are easily identified. Preliminary investigations using computer modeling techniques suggest that retardation is an effective control on radionuclide concentrations. Ion exchange reactions slow radionuclide migration and allow more time for radioactive decay and dispersion. For some radionuclides, solubility alone may limit concentrations to less than the maximum permissible now considered acceptable by the Federal Government. The effectiveness of the geochemical barrier is ultimately related to the repository site characteristics. Theory alone tells us that geochemical controls will be most efficient in an environment that provides for maximum ion exchange and the precipitation of insoluble compounds. In site selection, consideration should be given to rock barriers with high ion exchange capacity that might also act as semi-permeable membranes. Also important in evaluating the site's potential for effective geochemical controls are the oxidation potentials, pH and salinity of the groundwater

  2. NNDC database migration project

    Energy Technology Data Exchange (ETDEWEB)

    Burrows, Thomas W; Dunford, Charles L [U.S. Department of Energy, Brookhaven Science Associates (United States)

    2004-03-01

    NNDC Database Migration was necessary to replace obsolete hardware and software, to be compatible with the industry standard in relational databases (mature software, large base of supporting software for administration and dissemination and replication and synchronization tools) and to improve the user access in terms of interface and speed. The Relational Database Management System (RDBMS) consists of a Sybase Adaptive Server Enterprise (ASE), which is relatively easy to move between different RDB systems (e.g., MySQL, MS SQL-Server, or MS Access), the Structured Query Language (SQL) and administrative tools written in Java. Linux or UNIX platforms can be used. The existing ENSDF datasets are often VERY large and will need to be reworked and both the CRP (adopted) and CRP (Budapest) datasets give elemental cross sections (not relative I{gamma}) in the RI field (so it is not immediately obvious which of the old values has been changed). But primary and secondary intensities are now available on the same scale. The intensity normalization has been done for us. We will gain access to a large volume of data from Budapest and some of those gamma-ray intensity and energy data will be superior to what we already have.

  3. Radionuclide migration in soils

    Energy Technology Data Exchange (ETDEWEB)

    Demir, M [Ingenieurgesellschaft Bonnenberg und Drescher, Juelich (Germany, F.R.)

    1979-01-01

    Unplanned releases from a nuclear installation - e.g., leakage from a storage tank or other incident - can result in the escape of contaminants such as U, Pu, Cs, Sr, T etc. Nuclide transport through the ground is governed by characteristics of the subsurface hydrology and the specific nuclides under consideration. Unsaturated soil layers result in a transport rate so low as to negligible. Radionuclides reaching the ground water are assumed to endanger human life because of potential uncontrolled ingestion. The most dangerous nuclides are long-lived and not absorbed, or very poorly absorbed, in the soil. During migration of nuclides through saturated soil layers, the concentration can be reduced by dilution. Preliminary results indicate that tritium is spread with ground water velocity. Its concentration can be reduced only by diffusion, dispersion and radioactive decay. Alpha-emitters are strongly retained velocities of alpha-emitters are approximately one thousandth (10/sup -3/) that of T. Transport velocities of Cs and Sr are approximately one hundreth (10/sup -2/) and one tenth (10/sup -1/) that of T respectively.

  4. Radionuclide migration in soils

    International Nuclear Information System (INIS)

    Demir, M.

    1979-01-01

    Unplanned releases from a nuclear installation - e.g., leakage from a storage tank or other incident - can result in the escape of contaminants such as U, Pu, Cs, Sr, T etc. Nuclide transport through the ground is governed by characteristics of the subsurface hydrology and the specific nuclides under consideration. Unsaturated soil layers result in a transport rate so low as to negligible. Radionuclides reaching the ground water are assumed to endanger human life because of potential uncontrolled ingestion. The most dangerous nuclides are long-lived and not absorbed, or very poorly absorbed, in the soil. During migration of nuclides through saturated soil layers, the concentration can be reduced by dilution. Preliminary results indicate that tritium is spread with ground water velocity. Its concentration can be reduced only by diffusion, dispersion and radioactive decay. Alpha-emitters are strongly retained velocities of alpha-emitters are approximately one thousandth (10 -3 ) that of T. Transport velocities of Cs and Sr are approximately one hundreth (10 -2 ) and one tenth (10 -1 ) that of T respectively. (orig./HP) [de

  5. Psychosocial Aspects of Migration

    Directory of Open Access Journals (Sweden)

    Ayla Tuzcu

    2014-02-01

    Full Text Available The incident of migration that occurs as a result of the mobility of individuals between various regions and is considered a social change process brings along various factors. Among these factors, the most important one is the culture of the new society where the immigrant begins to live and the process of adaptation with this culture. Individuals from different cultures are required to live together, cope with differences and overcome the difficulties. The process of adaptation to the new lifestyle might cause the individual to have some feelings such as loneliness, socially isolation, being alienated, being regretful and self-depreciation, and consequently experience a greater stress. Being unable to cope with stress efficiently creates risks in individuals in terms of health problems such as anxiety and depression. Healthcare professionals are required to evaluate life styles, difficulties and coping levels of immigrants in order to protect and develop their mental health. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2014; 6(1.000: 56-66

  6. MIGRATION IMPACT ON ECONOMICAL SITUATION

    Directory of Open Access Journals (Sweden)

    Virginia COJOCARU

    2016-01-01

    Full Text Available This paper presents recent trends and flows of labor migration and its impact on economic and social life. Main aim of this research sets up the influence of the migration on the European economics and its competitiveness. Methods of research are: method of comparison, analysis method, method of deduction, method of statistics, modeling method. The economic impact of migration has been intensively studied but is still often driven by ill-informed perceptions, which, in turn, can lead to public antagonism towards migration. These negative views risk jeopardising efforts to adapt migration policies to the new economic and demographic challenges facing many countries. Migration Policy looks at the evidence for how immigrants affect the economy in three main areas: The labour market, public purse and economic growth. In Europe, the scope of labour mobility greatly increased within the EU/EFTA zones following the EU enlargements of 2004, 2007 and 2014-2015. This added to labour markets’ adjustment capacity. Recent estimates suggest that as much as a quarter of the asymmetric labour market shock – that is occurring at different times and with different intensities across countries – may have been absorbed by migration within a year.

  7. Income Inequality and Migration in Vietnam

    OpenAIRE

    NGUYEN, Tien Dung

    2012-01-01

    In this paper, we have analyzed the recent trends in income inequality, internal and international migrations and investigated the impact of migration on income distribution in Vietnam. Our analysis shows that the effects of migration on income inequality vary with different types of migration, depending on who migrate and where they migrate. Foreign remittances tend to flow toward more affluent households, and they increase income inequality. By contrast, domestic remittances accrue more to ...

  8. Use of Invasion Percolation Models To Study the Secondary Migration of Oil and Related Problems

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, G.

    1997-12-31

    This thesis studies simulations of the slow displacement of a wetting fluid by a non-wetting fluid in porous media and in a single fracture. The simulations are based on the invasion percolation model. New modified versions of the model are presented that simulate migration, fragmentation and coalescence processes of the clusters of non-wetting fluid. The resulting displacement patterns are characterized by scaling laws. In particular, simulations of the secondary migration of oil through porous homogeneous rock are discussed. Fractured rocks are extreme cases of inhomogeneous porous media. Simulations of the slow displacement of a wetting fluid by a non-wetting fluid in a single fracture using the standard invasion model are presented. There is a discussion of a scenario in which a cluster of non-wetting fluid migrates through a porous medium that was saturated with a wetting fluid. The migration is driven by continuously driven buoyancy forces. Both experiments and simulations are described. The same scenario is also studied theoretically and by simulations using a simplified percolation model of fluid migration in one dimension. The migration model in two dimensions, with constant buoyancy forces, is also discussed. Simulations of fluid migration, such as the secondary migration of oil, in two- and three-dimensional media are examined, the media having multi-affine properties rather than being homogeneous. Slow immiscible displacement processes in single fractures are studied using fractal geometries to model single fractures. 167 refs., 123 figs.

  9. Graduate and Research Program in Forced Migration and Refugee ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Palestinian refugees remain the largest single national group of refugees whose status has yet to be settled 60 years after the creation of the problem. Despite great interest in the subject, there are no graduate programs in Palestine that provide students with solid academic training in refugee and forced migration studies.

  10. [The productive structure and migration].

    Science.gov (United States)

    Fernandez, M

    1980-01-01

    The author discusses the possibility of determining the proper approach to the study of migration, with a focus on the importance of global, structural, and historical analysis of the phenomenon. A general theoretical outline is presented that tends to show migration as an integral part of the process of social change. The sociological focus on modernization as a theoretical guide influencing the study of migration in Latin America is evaluated. The concept of overpopulation is explained in relation to the migratory process, with reference to capitalist and non-capitalist forms of production.

  11. Migration of accreting giant planets

    Science.gov (United States)

    Robert, C.; Crida, A.; Lega, E.; Méheut, H.

    2017-09-01

    Giant planets forming in protoplanetary disks migrate relative to their host star. By repelling the gas in their vicinity, they form gaps in the disk's structure. If they are effectively locked in their gap, it follows that their migration rate is governed by the accretion of the disk itself onto the star, in a so-called type II fashion. Recent results showed however that a locking mechanism was still lacking, and was required to understand how giant planets may survive their disk. We propose that planetary accretion may play this part, and help reach this slow migration regime.

  12. MIGRATION – EFFECTS AND SOLUTIONS

    Directory of Open Access Journals (Sweden)

    Raluca Cruceru

    2012-12-01

    Full Text Available There are three main flows that influence workforce performance—worker migration, the dissemination of knowledge, and overseas development assistance. For the present paper we decided to deal with the analyses of these three, yet mainly migration. We considered it to be one of the most important phenomenon existent on the market at this hour and with the highest negative impact on the economic and social situation. We presented a case study regarding the situation of migration in Romania and the main candidates to Romanian intelligence imports, the main issues and possible solutions to the problems encountered.

  13. Cyclic grain boundary migration during high temperature fatigue--I: microstructural observations

    International Nuclear Information System (INIS)

    Langdon, T.G.; Gifkins, R.S.

    1983-01-01

    Experiments were conducted on high purity lead at room temperature using reverse bending and torsion fatigue at low cyclic frequencies (less than or equal to1.50 Hz). Metallographic observations after testing show that there is a one-to-one correspondence between the markings from grain boundary migration and the number and pattern of cyclic loading, and this correspondence is maintained up to >100 cycles. Grain boundary sliding occurs in each cycle in addition to the migration, and this leads to the development of broad triple point folds. If the strain amplitude is maintained constant, it is shown that the average distance migrated in each cycle increases as the imposed frequency is decreased. The distance migrated is often exceptionally large in the first cycle of testing, and there is often a similar large initial displacement if the test is interrupted for periods of time from 1 to 24 h and then continued. For large grain sizes (greater than or equal to 2000μm), the migration markings may lead to a zig-zag pattern where the individual segments lie fairly close to 45 0 to the stress axis. A model is described which accounts for the one-to-one correspondence and which is consistent with a fine structure observed within the migration markings

  14. Tumor regression induced by intratumor therapy with a disabled infectious single cycle (DISC) herpes simplex virus (HSV) vector, DISC/HSV/murine granulocyte-macrophage colony-stimulating factor, correlates with antigen-specific adaptive immunity.

    Science.gov (United States)

    Ali, Selman A; Lynam, June; McLean, Cornelia S; Entwisle, Claire; Loudon, Peter; Rojas, José M; McArdle, Stephanie E B; Li, Geng; Mian, Shahid; Rees, Robert C

    2002-04-01

    Direct intratumor injection of a disabled infectious single cycle HSV-2 virus encoding the murine GM-CSF gene (DISC/mGM-CSF) into established murine colon carcinoma CT26 tumors induced a significant delay in tumor growth and complete tumor regression in up to 70% of animals. Pre-existing immunity to HSV did not reduce the therapeutic efficacy of DISC/mGM-CSF, and, when administered in combination with syngeneic dendritic cells, further decreased tumor growth and increased the incidence of complete tumor regression. Direct intratumor injection of DISC/mGM-CSF also inhibited the growth of CT26 tumor cells implanted on the contralateral flank or seeded into the lungs following i.v. injection of tumor cells (experimental lung metastasis). Proliferation of splenocytes in response to Con A was impaired in progressor and tumor-bearer, but not regressor, mice. A potent tumor-specific CTL response was generated from splenocytes of all mice with regressing, but not progressing tumors following in vitro peptide stimulation; this response was specific for the gp70 AH-1 peptide SPSYVYHQF and correlated with IFN-gamma, but not IL-4 cytokine production. Depletion of CD8(+) T cells from regressor splenocytes before in vitro stimulation with the relevant peptide abolished their cytolytic activity, while depletion of CD4(+) T cells only partially inhibited CTL generation. Tumor regression induced by DISC/mGM-CSF virus immunotherapy provides a unique model for evaluating the immune mechanism(s) involved in tumor rejection, upon which tumor immunotherapy regimes may be based.

  15. Strontium-90 migration in Hanford sediments, USA

    International Nuclear Information System (INIS)

    Steefel, C.I.; Yang, L.; Carroll, S.A.; Roberts, S.; Zachara, J.M.; Yabusaki, S.B.

    2005-01-01

    Full text of publication follows: Strontium-90 is an important risk-driving contaminant at the Hanford site in eastern Washington, USA. Disposal operations at the Hanford 100-N area released millions of liters of reactor cooling water containing high concentrations of strontium-90 into the vadose zone immediately adjacent to the Columbia River. The effectiveness of pump-and-treat methods for remediation have been questioned, largely because the strontium is strongly sorbed on subsurface sediments via ion exchange reactions and co-precipitation in carbonates. In addition, groundwater monitoring wells show a fluctuating seasonal behavior in which high strontium-90 concentrations correlate with high Columbia River stage, even while average concentrations remain approximately constant. A series of fully saturated reactive transport column experiments have been conducted to investigate the important controls on strontium migration in Hanford groundwater [1]. The experiments were designed to investigate the multicomponent cation exchange behavior of strontium in competition with the cations Na + , Ca +2 , and Mg +2 , the concentration of which differs between river water and groundwater. Reactive transport modeling of the experiments indicates that the Sr +2 selectivity coefficient becomes larger with increasing NaNO 3 concentration, a behavior also shown by the divalent cations Ca +2 and Mg +2 . A new set of column experiments investigates the effect of wetting and drying cycles on strontium- 90 sorption and migration by considering episodic flow in Hanford sediments. In addition, the effect of fluctuating aquifer chemistry as a result of changes in the Columbia River stage on Sr +2 sorption is addressed. Modeling of multicomponent reactive transport under variably saturated conditions is used to interpret the results of the episodic flow/chemistry experiments. [1] Experimental and modeling studies of the migration behavior of strontium in Hanford sediments, USA. C

  16. MRI of neuronal migration disorders

    International Nuclear Information System (INIS)

    Engelbrecht, V.

    1996-01-01

    Twenty-one MRI examinations of the brain were performed in 19 children with neuronal migration disorders. Multiplanar oriented spin-echo sequences were on a scanner with 1.5 T. In 8 children we performed an additional turbo-inversion recovery (TIR) sequence. Results of sonography or CT from five children were compared with MRI scans. Using the actual nomenclature, we found the following migration disorders: Lissencephaly (n=6), cobblestone lissencephaly with Walker-Warbung syndrome (WWS) (n=2), polymicrogyria and schizencephaly (n=2), focal heterotopia (n=5), diffuse heterotopie (n=2) and hemimegalencephaly (n=2). MRI was superior to CT and sonography in all children. Except for the two boys with WWS, the TIR sequence was the best to demonstrate the changes in migration disorder because of the high contrast between gray and white matter. We demonstrate the characteristic features of the different migration disorders and compare them with the existing literature. (orig.) [de

  17. The migration challenge for PAYG

    Czech Academy of Sciences Publication Activity Database

    Aslanyan, Gurgen

    2014-01-01

    Roč. 27, č. 4 (2014), s. 1023-1038 ISSN 0933-1433 Institutional support: RVO:67985998 Keywords : public pension s * PAYG * unskilled migration Subject RIV: AH - Economics Impact factor: 1.109, year: 2014

  18. The migration challenge for PAYG

    Czech Academy of Sciences Publication Activity Database

    Aslanyan, Gurgen

    2014-01-01

    Roč. 27, č. 4 (2014), s. 1023-1038 ISSN 0933-1433 Institutional support: PRVOUK-P23 Keywords : public pension s * PAYG * unskilled migration Subject RIV: AH - Economics Impact factor: 1.109, year: 2014

  19. Labour market frictions and migration

    NARCIS (Netherlands)

    Cremers, Jan

    2016-01-01

    The 4th contribution to the series INT-AR papers is dedicated to the methods of assessing labour market frictions. The paper provides a (brief) international comparison of the role of labour migration in solving these frictions.

  20. Fluid migration studies in salt

    International Nuclear Information System (INIS)

    Shefelbine, H.C.; Raines, G.E.

    1980-01-01

    This discussion will be limited to the migration of water trapped in the rock salt under the influence of the heat field produced by nuclear waste. This is of concern because hypotheticl scenarios have been advanced in which this fluid movement allows radionuclides to escape to the biosphere. While portions of these scenarios are supported by observation, none of the complete scenarios has been demonstrated. The objectives of the present fluid migration studies are two-fold: 1. determine the character of the trapped fluid in terms of quantity, habitat and chemical constituents; and 2. define the mechanisms that cause the fluid to migrate toward heat sources. Based on the observations to date, fluid migration will not have a major impact on repository integrity. However, the above objectives will be pursued until the impacts, if any, can be quantified

  1. Effort Estimation in BPMS Migration

    Directory of Open Access Journals (Sweden)

    Christopher Drews

    2018-04-01

    Full Text Available Usually Business Process Management Systems (BPMS are highly integrated in the IT of organizations and are at the core of their business. Thus, migrating from one BPMS solution to another is not a common task. However, there are forces that are pushing organizations to perform this step, e.g. maintenance costs of legacy BPMS or the need for additional functionality. Before the actual migration, the risk and the effort must be evaluated. This work provides a framework for effort estimation regarding the technical aspects of BPMS migration. The framework provides questions for BPMS comparison and an effort evaluation schema. The applicability of the framework is evaluated based on a simplified BPMS migration scenario.

  2. Understanding oceanic migrations with intrinsic biogeochemical markers.

    Directory of Open Access Journals (Sweden)

    Raül Ramos

    2009-07-01

    Full Text Available Migratory marine vertebrates move annually across remote oceanic water masses crossing international borders. Many anthropogenic threats such as overfishing, bycatch, pollution or global warming put millions of marine migrants at risk especially during their long-distance movements. Therefore, precise knowledge about these migratory movements to understand where and when these animals are more exposed to human impacts is vital for addressing marine conservation issues. Because electronic tracking devices suffer from several constraints, mainly logistical and financial, there is emerging interest in finding appropriate intrinsic markers, such as the chemical composition of inert tissues, to study long-distance migrations and identify wintering sites. Here, using tracked pelagic seabirds and some of their own feathers which were known to be grown at different places and times within the annual cycle, we proved the value of biogeochemical analyses of inert tissue as tracers of marine movements and habitat use. Analyses of feathers grown in summer showed that both stable isotope signatures and element concentrations can signal the origin of breeding birds feeding in distinct water masses. However, only stable isotopes signalled water masses used during winter because elements mainly accumulated during the long breeding period are incorporated into feathers grown in both summer and winter. Our findings shed new light on the simple and effective assignment of marine organisms to distinct oceanic areas, providing new opportunities to study unknown migration patterns of secretive species, including in relation to human-induced mortality on specific populations in the marine environment.

  3. Cell migration during heart regeneration in zebrafish.

    Science.gov (United States)

    Tahara, Naoyuki; Brush, Michael; Kawakami, Yasuhiko

    2016-07-01

    Zebrafish possess the remarkable ability to regenerate injured hearts as adults, which contrasts the very limited ability in mammals. Although very limited, mammalian hearts do in fact have measurable levels of cardiomyocyte regeneration. Therefore, elucidating mechanisms of zebrafish heart regeneration would provide information of naturally occurring regeneration to potentially apply to mammalian studies, in addition to addressing this biologically interesting phenomenon in itself. Studies over the past 13 years have identified processes and mechanisms of heart regeneration in zebrafish. After heart injury, pre-existing cardiomyocytes dedifferentiate, enter the cell cycle, and repair the injured myocardium. This process requires interaction with epicardial cells, endocardial cells, and vascular endothelial cells. Epicardial cells envelope the heart, while endocardial cells make up the inner lining of the heart. They provide paracrine signals to cardiomyocytes to regenerate the injured myocardium, which is vascularized during heart regeneration. In addition, accumulating results suggest that local migration of these major cardiac cell types have roles in heart regeneration. In this review, we summarize the characteristics of various heart injury methods used in the research community and regeneration of the major cardiac cell types. Then, we discuss local migration of these cardiac cell types and immune cells during heart regeneration. Developmental Dynamics 245:774-787, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  4. Brine migration in hot-pressed polycrystalline sodium chloride

    International Nuclear Information System (INIS)

    Biggers, J.V.; Dayton, G.O.

    1982-12-01

    This report describes experiments designed to provide data on brine migration in polycrystalline salt. Polycrystalling samples of various grain sizes, density, and purity were prepared from several commercial-grade salts by hot-pressing. Three distinct experimental set-ups were used to place salt billets in an induced thermal gradient in contact with brine source. The test designs varied primarily in the way in which the thermal gradient was applied and monitored and the way in which brine migration was determined. All migration was in enclosed vessels which precluded visual observation of brine movement through the microstructure. Migration velocities were estimated either by the timed appearance of brine at the hot face of the sample, or by determination of the penetration distance of migration artifacts in the microstructure after tests of fixed duration. For various reasons both of these methods were subject to a large degree of error. Our results suggest, however, that the migration velocity in dense polycrystalline salt may be at least an order of magnitude greater than that suggested by single-crystal experiments. Microstructural analysis shows that brine prefers to migrate along paths of high crystalline activity such as grain and subgrain boundaries and is dispersed rather quickly in the microstructure. A series of tests were performed using various types of tracers in brine in order to flag migration paths and locate brine in the microstructure more decisively. These attempts failed and it appears that only the aqueous portion of the brine moves through the microstructure with the dissolved ions being lost and replaced rather quickly. This suggests the use of deuterium as a tracer in future work

  5. Waste migration in shallow burial sites under unsaturated flow conditions

    International Nuclear Information System (INIS)

    Eicholz, G.G.; Whang, J.

    1987-01-01

    Unsaturated conditions prevail in many shallow-land burial sites, both in arid and humid regions. Unless a burial site is allowed to flood and possibly overflow, a realistic assessment of any migration scenario must take into account the conditions of unsaturated flow. These are more difficult to observe and to model, but introduce significant changes into projected rates of waste leaching and waste migration. Column tests have been performed using soils from the Southeastern coastal plain to observe the effects of varying degrees of ''unsaturation'' on the movement of radioactive tracers. The moisture content in the columns was controlled by maintaining various levels of hydrostatic suction on soil columns whose hydrodynamic characteristics had been determined carefully. Tracer tests, employing Cs-137, I-131 and Ba-133 were used to determine migration profiles and to follow their movement down the column for different suction values. A calculational model has been developed for unsaturated flow and seems to match the observations fairly well. It is evident that a full description of migration processes must take into account the reduced migration rates under unsaturated conditions and the hysteresis effects associated with wetting-drying cycles

  6. Migration and winter distribution of the Chestnutcollared Longspur

    Directory of Open Access Journals (Sweden)

    Ellison Kevin

    2017-12-01

    Full Text Available The Chestnut-collared Longspur (Calcarius ornatus is one of five grassland songbirds, endemic within North America, with populations that have declined >65% since the 1960s. These species breed and winter in the northern and southern Great Plains, respectively. Identifying migration routes, wintering sites, and the timing of their habitat use is key for understanding the relative magnitude of threats across the annual cycle and effectively targeting habitats for conservation. We tracked migratory movements of seven Chestnut-collared Longspurs with light-level geolocators deployed in Canada. Individuals wintered up to 112-1,200km apart. All followed the Central Flyway, circumvented high-elevation terrain, and traveled east of the breeding location. Unlike most songbirds, the durations of spring and fall migrations were similar; on average 42 ± 7d and 41 ± 5d during fall and spring migrations, respectively, for an approximately 2,000km migration; this highlights the need to better understand habitat requirements during migration for grassland songbirds. Using geospatial habitat data, we assessed winter distribution overlap with four other endemic grassland songbirds; wintering range overlapped 63-99%. Future studies should use more precise devices (e.g., archival GPS units, programmed for data collection dates from this study, to identify specific migratory sites for better conserving this and associated grassland species.

  7. Fisetin regulates astrocyte migration and proliferation in vitro

    Science.gov (United States)

    Wang, Nan; Yao, Fang; Li, Ke; Zhang, Lanlan; Yin, Guo; Du, Mingjun; Wu, Bingyi

    2017-01-01

    Fisetin (3,3′,4′,7-tetrahydroxyflavone) is a plant flavonol found in fruits and vegetables that has been reported to inhibit migration and proliferation in several types of cancer. Reactive astrogliosis involves astrocyte migration and proliferation, and contributes to the formation of glial scars in central nervous system (CNS) disorders. However, the effect of fisetin on the migration and proliferation of astrocytes remains unclear. In this study, we found that fisetin inhibited astrocyte migration in a scratch-wound assay and diminished the phosphorylation of focal adhesion kinase (FAK; Tyr576/577 and paxillin (Tyr118). It also suppressed cell proliferation, as indicated by the decreased number of 5-ethynyl-2′-deoxyuridine (EdU)-positive cells, induced cell cycle arrest in the G1 phase, reduced the percentage of cells in the G2 and S phase (as measured by flow cytometry), and decreased cyclin D1 expression, but had no effect on apoptosis. Fisetin also decreased the phosphorylation levels of Akt and extracellular signal-regulated kinase (Erk)1/2, but had no effect on the phosphorylation of p38 mitogen-activated protein kinase (MAPK). These results indicate that fisetin inhibits aggressive cell phenotypes by suppressing cell migration and proliferation via the Akt/Erk signaling pathway. Fisetin may thus have potential for use as a therapeutic strategy targeting reactive astrocytes, which may lead to the inhibition of glial scar formation in vitro. PMID:28204814

  8. A quantitative analysis of major determinants of rural-urban migration in Nigeria.

    Science.gov (United States)

    Anyanwu, S O

    1992-11-01

    "This paper discusses some major determinants of rural-urban migration in Nigeria using the logit estimation technique. It utilizes cross-sectional data generated from a national sample survey of internal migration conducted...between January and March 1988.... The empirical results revealed that the significant determinants of rural-urban migration in Nigeria are income, contact, cost, spoken English, ability to speak two Nigerian languages, distance, marital status, sex and ethnicity. The results further suggest that rural-urban migration is selective of single people and males. Proximity to urban areas where prospective migrants have relatives, friends and townspeople is an important factor." excerpt

  9. SOX15 regulates proliferation and migration of endometrial cancer cells.

    Science.gov (United States)

    Rui, Xiaohui; Xu, Yun; Jiang, Xiping; Guo, Caixia; Jiang, Jingting

    2017-10-31

    The study aimed to investigate the effects of Sry-like high mobility group box 15 ( SOX15 ) on proliferation and migration of endometrial cancer (EC) cells. Immunohistochemistry (IHC) was applied to determine the expression of SOX15 in EC tissues and adjacent tissues. We used cell transfection method to construct the HEC-1-A and Ishikawa cell lines with stable overexpression and low expression SOX15 Reverse-transcription quantitative real-time PCR (RT-qPCR) and Western blot were performed to examine expression of SOX15 mRNA and SOX15 protein, respectively. By conducting a series of cell proliferation assay and migration assay, we analyzed the influence of SOX15 overexpression or low expression on EC cell proliferation and migration. The expression of SOX15 mRNA and protein in EC tissues was significantly lower than that in adjacent tissues. After lentivirus-transfecting SOX15 , the expression level of SOX15 mRNA and protein was significantly increased in cells of SOX15 group, and decreased in sh- SOX15 group. Overexpression of SOX15 could suppress cell proliferation, while down-regulation of SOX15 increased cell proliferation. Flow cytometry results indicated that overexpression of SOX15 induced the ratio of cell-cycle arrest in G 1 stage. In addition, Transwell migration assay results showed that SOX15 overexpression significantly inhibited cell migration, and also down-regulation of SOX15 promoted the migration. As a whole, SOX15 could regulate the proliferation and migration of EC cells and up- regulation of SOX15 could be valuable for EC treatment. © 2017 The Author(s).

  10. Return Migration and Working Choices

    OpenAIRE

    TANI, Massimiliano; MAHUTEAU, Stéphane

    2008-01-01

    Collective Action to Support the Reintegration of Return Migrants in their Country of Origin (MIREM) This paper uses the recent survey carried out in the framework of the MIREM project on returnees to Algeria, Morocco and Tunisia and studies the duration of emigration and the labour force status upon returning. The results suggest that age and the year of emigration play a central role in the migration decision, but they do not support the hypothesis that the duration of migration is deter...

  11. Roosts and migrations of swallows

    OpenAIRE

    Winkler, David W.

    2006-01-01

    Swallows of the north temperate zone display a wide variety of territorial behaviour during the breeding season, but as soon as breeding is over, they all appear to adopt a pattern of independent diurnal foraging interleaved with aggregation every night in dense roosts. Swallows generally migrate during the day, feeding on the wing. On many stretches of their annual journeys, their migrations can thus be seen as the simple spatial translation of nocturnal roost sites with foraging routes stra...

  12. International Student Migration to Germany

    OpenAIRE

    Donata Bessey

    2007-01-01

    This paper presents first empirical evidence on international student migration to Germany. I use a novel approach that analyzes student mobility using an augmented gravity equation and find evidence of strong network effects and of the importance of distance - results familiar from the empirical migration literature. However, the importance of disposable income in the home country does not seem to be too big for students, while the fact of being a politically unfree country decreases migrati...

  13. Effort Estimation in BPMS Migration

    OpenAIRE

    Drews, Christopher; Lantow, Birger

    2018-01-01

    Usually Business Process Management Systems (BPMS) are highly integrated in the IT of organizations and are at the core of their business. Thus, migrating from one BPMS solution to another is not a common task. However, there are forces that are pushing organizations to perform this step, e.g. maintenance costs of legacy BPMS or the need for additional functionality. Before the actual migration, the risk and the effort must be evaluated. This work provides a framework for effort estimation re...

  14. A new method to assess the influence of migration from polymeric materials on the biostability of drinking water.

    Science.gov (United States)

    Bucheli-Witschel, Margarete; Kötzsch, Stefan; Darr, Stephan; Widler, Roland; Egli, Thomas

    2012-09-01

    After having produced drinking water of high quality it is of vital interest to distribute the water without compromising its quality neither by recontamination nor by microbial regrowth. To minimize regrowth, the strategy of distributing biostable water is followed in several European countries. This implies on one hand the production of water that has a low level of growth-supporting nutrients, in particular organic carbon compounds, and, on the other hand, using materials for storage/distribution that have a low biofilm formation potential and from which only low amounts of total organic carbon (TOC) leach into the water phase. Currently, the approval of materials in contact with drinking water relies on two tests, a migration test and a biofilm formation test. Here we describe an extended migration testing procedure that allows to obtain information not only on the amount of chemical compounds but also on the amount of growth-supporting compounds leaching into the water. In short, the test developed combines several migration cycles and subsequent measurement of the TOC with a novel, fast and reliable test method for determining the assimilable organic carbon (AOC) in the migration waters. AOC gives an indication on the growth-supporting properties of the material. Thus, an initial characterisation of a material with respect to its suitability for usage in contact with drinking water can be performed in a single assay. Results obtained with the new assay for a number of materials typically used in drinking water and sanitary installations are reported. Copyright © 2012 Elsevier Ltd. All rights reserved.

  15. Palaearctic-African Bird Migration

    DEFF Research Database (Denmark)

    Iwajomo, Soladoye Babatola

    Bird migration has attracted a lot of interests over past centuries and the methods used for studying this phenomenon has greatly improved in terms of availability, dimension, scale and precision. In spite of the advancements, relatively more is known about the spring migration of trans-Saharan m......Bird migration has attracted a lot of interests over past centuries and the methods used for studying this phenomenon has greatly improved in terms of availability, dimension, scale and precision. In spite of the advancements, relatively more is known about the spring migration of trans...... of birds from Europe to Africa and opens up the possibility of studying intra-African migration. I have used long-term, standardized autumn ringing data from southeast Sweden to investigate patterns in biometrics, phenology and population trends as inferred from annual trapping totals. In addition, I...... in the population of the species. The papers show that adult and juvenile birds can use different migration strategies depending on time of season and prevailing conditions. Also, the fuel loads of some individuals were theoretically sufficient for a direct flight to important goal area, but whether they do so...

  16. Investigation on nuclide migration behaviors

    International Nuclear Information System (INIS)

    Baik, Minhoon; Park, Chungkyun; Kim, Seungsoo

    2012-04-01

    In this study, we investigated the properties of geochemical reactions and sorption of high-level radionuclides and highly-mobile radionuclides in deep geological disposal environments. We also analyzed the dissolution properties of pyro wastes and constructed databases for the geochemical reactions and sorption for the safety assessment of HLW disposal. Technologies for measuring diffusion depths of radionuclides through fracture surfaces and rock matrix were developed in KURT conditions and their diffusion properties were analyzed and evaluated. The combined reactions of radionuclide/mineral/microbe in deep disposal environments were investigated and the effects of microbe on the radionuclide migration and disposal system behaviors were evaluated. In-situ solute migration system and on-line monitoring system were installed in KURT and the migration and retardation behaviors of various solutes and their interaction with fracture-filling materials were investigated. Basic properties of KURT groundwater colloids were analyzed using various methods. In addition, in-situ colloid migration experiments through a rock fracture were carried out and the developed migration model was verified. We have participated in Colloid Formation and Migration (CFM) international joint project in GTS and obtained reliability for our research results by comparing research results each other

  17. Safe cycling!

    CERN Multimedia

    Anaïs Schaeffer

    2012-01-01

    The HSE Unit will be running a cycling safety campaign at the entrances to CERN's restaurants on 14, 15 and 16 May. Pop along to see if they can persuade you to get back in the saddle!   With summer on its way, you might feel like getting your bike out of winter storage. Well, the HSE Unit has come up with some original ideas to remind you of some of the most basic safety rules. This year, the prevention campaign will be focussing on three themes: "Cyclists and their equipment", "The bicycle on the road", and "Other road users". This is an opportunity to think about the condition of your bike as well as how you ride it. From 14 to 16 May, representatives of the Swiss Office of Accident Prevention and the Touring Club Suisse will join members of the HSE Unit at the entrances to CERN's restaurants to give you advice on safe cycling (see box). They will also be organising three activity stands where you can test your knowle...

  18. Cycle 22

    International Nuclear Information System (INIS)

    Kappernman, J.G.; Albertson, V.D.

    1991-01-01

    This paper reports that for many electric utility systems, Solar Cycle 22 has been the first introduction to the phenomena of Geomagnetic Disturbances and the disrupting and damaging effects that they can have upon modern power systems. For all intents and purposes, Power Industry awareness of Cycle 22 started with a bang during the Great Geomagnetic Storm of March 13, 1989. This storm caused a blackout to the entire Province of Quebec, permanently damaged a large nuclear plant GSU transformer in New Jersey, and created enough havoc across the entire North American power grid to create the plausible threat of a massive power system blackout. The flurry of activity and investigation that followed has led many engineers to realize that their power systems are indeed vulnerable to this phenomena and if anything are becoming ever more vulnerable as the system grows to meet future requirements. As a result some organizations such as Hydro Quebec, PSE and G, and the PJM Pool now implement strategic measures as a remedial response to detection of geomagnetic storm conditions. Many more companies pay particularly close attention to storm forecasts and alerts, and the industry in general has accelerated research and monitoring activities through their own means of in concert with the Electric Power Research Institute (EPRI)

  19. The Female Face of Migration in Sub-Saharan Africa | Masanja ...

    African Journals Online (AJOL)

    Female migrants are disproportionately young and single. ... Women particularly the younger ones from ruralareas are migrating to work as domestics. ... changing role in migratory flows andreflect the needs and priorities of migrant women.

  20. Migration and development in Pakistan: some selected issues.

    Science.gov (United States)

    Irfan, M

    1986-01-01

    Various sources of cross-sectional data were used as a basis for considering some of the interrelationships between migration and development in Pakistan, particularly the effects on the labor-exporting rural areas. The available data yield a range of estimates as to the level of mobility. During the 1970s, around 7-10% of Pakistan's population changed residence. The incidence of migration was higher among females than males. Women's greater propensity to migrate can be attributed primarily to patrilocal marriage customs wherein a significant proportion of females migrate, particularly in the rural areas. According to the 1979 Population, Labor Force and Migration Survey, the share of migrants in the total female population fell from 11.8% to 4.8% when migration for marriage is excluded. In Pakistan, mobility is predominantly local or involves short distances only. Only 19% of the internal migrants crossed provincial boundaries. 29.8% of the flow was from rural to urban areas. The remainder of the volume of internal migration was shared equally by inter-city and urban-to-rural migrants. The coincidence of the timing of marriage and entry into the labor market in individuals' life cycles generated a peak for the 15-24 age group in the age-mobility curve. A positive association exists between education and the propensity to migrate. In terms of origin, the propensity to move exhibited by the higher educational group was higher (33%) in rural areas than in urban areas (10%). 83% of this group from rural areas moved to urban centers; 80% of the same educational background chose another urban center as destination. The data on remittances may suffer both from reporting areas and being unrepresentative. The remittances estimated due to internal migration, on the basis of the PLM survey, amounted to 3 billion rupees in 1978. On average, remittances accounted for 35% of the earnings of the migrants. Average remittances were substantially less than the earnings of

  1. All tied up: Tied staying and tied migration within the United States, 1997 to 2007

    Directory of Open Access Journals (Sweden)

    Thomas J. Cooke

    2013-10-01

    Full Text Available Background: The family migration literature presumes that women are cast into the role of the tied migrant. However, clearly identifying tied migrants is a difficult empirical task since it requires the identification of a counterfactual: Who moved but did not want to? Objective: This research develops a unique methodology to directly identify both tied migrants and tied stayers in order to investigate their frequency and determinants. Methods: Using data from the 1997 through 2009 U.S. Panel Study of Income Dynamics (PSID, propensity score matching is used to match married individuals with comparable single individuals to create counterfactual migration behaviors: who moved but would not have moved had they been single (tied migrants and who did not move but would have moved had they been single (tied stayers. Results: Tied migration is relatively rare and not limited just to women: rates of tied migration are similar for men and women. However, tied staying is both more common than tied migration and equally experienced by men and women. Consistent with the body of empirical evidence, an analysis of the determinants of tied migration and tied staying demonstrates that family migration decisions are imbued with gender. Conclusions: Additional research is warranted to validate the unique methodology developed in this paper and to confirm its results. One line of future research should be to examine the effects of tied staying, along with tied migration, on well-being, union stability, employment, and earnings.

  2. SiMA: A simplified migration assay for analyzing neutrophil migration.

    Science.gov (United States)

    Weckmann, Markus; Becker, Tim; Nissen, Gyde; Pech, Martin; Kopp, Matthias V

    2017-07-01

    In lung inflammation, neutrophils are the first leukocytes migrating to an inflammatory site, eliminating pathogens by multiple mechanisms. The term "migration" describes several stages of neutrophil movement to reach the site of inflammation, of which the passage of the interstitium and basal membrane of the airway are necessary to reach the site of bronchial inflammation. Currently, several methods exist (e.g., Boyden Chamber, under-agarose assay, or microfluidic systems) to assess neutrophil mobility. However, these methods do not allow for parameterization on single cell level, that is, the individual neutrophil pathway analysis is still considered challenging. This study sought to develop a simplified yet flexible method to monitor and quantify neutrophil chemotaxis by utilizing commercially available tissue culture hardware, simple video microscopic equipment and highly standardized tracking. A chemotaxis 3D µ-slide (IBIDI) was used with different chemoattractants [interleukin-8 (IL-8), fMLP, and Leukotriene B4 (LTB 4 )] to attract neutrophils in different matrices like Fibronectin (FN) or human placental matrix. Migration was recorded for 60 min using phase contrast microscopy with an EVOS ® FL Cell Imaging System. The images were normalized and texture based image segmentation was used to generate neutrophil trajectories. Based on these spatio-temporal information a comprehensive parameter set is extracted from each time series describing the neutrophils motility, including velocity and directness and neutrophil chemotaxis. To characterize the latter one, a sector analysis was employed enabling the quantification of the neutrophils response to the chemoattractant. Using this hard- and software framework we were able to identify typical migration profiles of the chemoattractants IL-8, fMLP, and LTB 4 , the effect of the matrices FN versus HEM as well as the response to different medications (Prednisolone). Additionally, a comparison of four asthmatic and

  3. International migration: a global challenge.

    Science.gov (United States)

    Martin, P; Widgren, J

    1996-04-01

    Trends in international migration are presented in this multiregional analysis. Seven of the world's wealthiest countries have about 33% of the world's migrant population, but under 16% of the total world population. Population growth in these countries is substantially affected by the migrant population. The migration challenge is external and internal. The external challenge is to balance the need for foreign labor and the commitment to human rights for those migrants seeking economic opportunity and political freedom. The internal challenge is to assure the social adjustment of immigrants and their children and to integrate them into society as citizens and future leaders. Why people cross national borders and how migration flows are likely to evolve over the next decades are explained. This report also presents some ways that countries can manage migration or reduce the pressures which force people to migrate. It is recommended that receiving nations control immigration by accelerating global economic growth and reducing wars and human rights violations. This report examines the impact of immigration on international trade, aid, and direct intervention policies. Although migration is one of the most important international economic issues, it is not coordinated by an international group. The European experience indicates that it is not easy to secure international cooperation on issues that affect national sovereignty. It is suggested that countries desiring control of their borders should remember that most people never cross national borders to live or work in another country, that 50% of the world's migrants move among developing countries, and that countries can shift from being emigration to immigration countries. The author suggests that sustained reductions in migration pressure are a better alternative than the "quick fixes" that may invite the very much feared mass and unpredictable movements.

  4. Analysis of oil migration in one and two-stage heat pumps; Analyse de la migration d'huile dans les pompes a chaleur mono- et bi-etagees

    Energy Technology Data Exchange (ETDEWEB)

    Zehnder, M.; Favrat, D.

    2003-07-01

    This final report for the Swiss Federal Office of Energy SFOE describes work done at the Swiss Federal Institute of Technology in Lausanne, Switzerland, as part of the Swiss Retrofit Heat Pump project that examines ways of replacing traditional oil-fired domestic heating systems with heat pumps. The apparatus used to investigate the migration of oil within the refrigeration circuit of a purpose-built air-water heat pump is described. The construction of the heat pump, which could be operated in single or two-stage mode, is described and the results obtained from the investigations are presented. The properties of lubricants used in heat pumps are discussed and the techniques used to measure the oil concentration in the various parts of the refrigeration cycle, which include the use of an infra-red spectrometer, are described.

  5. Benefits of the destinations, not costs of the journeys, shape partial migration patterns

    Science.gov (United States)

    Yackulic, Charles B.; Blake, Stephen; Bastille-Rousseau, Guillaume

    2017-01-01

    1. The reasons that lead some animals to seasonally migrate, and others to remain in the same area year-round, are poorly understood. Associations between traits, such as body size, and migration provide clues. For example, larger species and individuals are more likely to migrate.2. One explanation for this size bias in migration is that larger animals are capable of moving faster (movement hypothesis). However, body size is linked to many other biological processes. For instance, the energetic balances of larger animals are generally more sensitive to variation in food density because of body size effects on foraging and metabolism and this sensitivity could drive migratory decisions (forage hypothesis).3. Identifying the primary selective forces that drive migration ultimately requires quantifying fitness impacts over the full annual migratory cycle. Here, we develop a full annual migratory cycle model from metabolic and foraging theory to compare the importance of the forage and movement hypotheses. We parameterize the model for Galapagos tortoises, which were recently discovered to be size-dependent altitudinal migrants.4. The model predicts phenomena not included in model development including maximum body sizes, the body size at which individuals begin to migrate, and the seasonal timing of migration and these predictions generally agree with available data. Scenarios strongly support the forage hypothesis over the movement hypothesis. Furthermore, male Galapagos tortoises on Santa Cruz Island would be unable to grow to their enormous sizes without access to both highlands and lowlands.5. Whereas recent research has focused on links between traits and the migratory phases of the migratory cycle, we find that effects of body size on the non-migratory phases are far more important determinants of the propensity to migrate. Larger animals are more sensitive to changing forage conditions than smaller animals with implications for maintenance of migration and

  6. The LifeCycle model

    DEFF Research Database (Denmark)

    Krink, Thiemo; Løvbjerg, Morten

    2002-01-01

    genetic algorithms (GAs), particle swarm optimisation (PSOs), and stochastic hill climbing to create a generally well-performing search heuristics. In the LifeCycle model, we consider candidate solutions and their fitness as individuals, which, based on their recent search progress, can decide to become...... either a GA individual, a particle of a PSO, or a single stochastic hill climber. First results from a comparison of our new approach with the single search algorithms indicate a generally good performance in numerical optimization....

  7. Short-term organic carbon migration from polymeric materials in contact with chlorinated drinking water.

    Science.gov (United States)

    Mao, Guannan; Wang, Yingying; Hammes, Frederik

    2018-02-01

    Polymeric materials are widely used in drinking water distribution systems. These materials could release organic carbon that supports bacterial growth. To date, the available migration assays for polymeric materials have not included the potential influence of chlorination on organic carbon migration behavior. Hence, we established a migration and growth potential protocol specifically for analysis of carbon migration from materials in contact with chlorinated drinking water. Four different materials were tested, including ethylene propylene dienemethylene (EPDM), poly-ethylene (PEX b and PEX c) and poly-butylene (PB). Chlorine consumption rates decreased gradually over time for EPDM, PEXc and PB. In contrast, no free chlorine was detected for PEXb at any time during the 7 migration cycles. Total organic carbon (TOC) and assimilable organic carbon (AOC) was evaluated in both chlorinated and non-chlorinated migrations. TOC concentrations for EPDM and PEXb in chlorinated migrations were significantly higher than non-chlorinated migrations. The AOC results showed pronounced differences among tested materials. AOC concentrations from chlorinated migration waters of EPDM and PB were higher compared to non-chlorinated migrations, whereas the opposite trend was observed for PEXb and PEXc. There was also a considerable difference between tested materials with regards to bacterial growth potential. The results revealed that the materials exposed to chlorine-influenced migration still exhibited a strong biofilm formation potential. The overall results suggested that the choice in material would make a considerable difference in chlorine consumption and carbon migration behavior in drinking water distribution systems. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. International nurse migrations: Global trends

    Directory of Open Access Journals (Sweden)

    Ivković Marija

    2011-01-01

    Full Text Available This paper presents global trends of migration of nurses, as specific qualified personnel in high demand. In the last couple of decades, and especially in the last couple of years, many countries have faced the problem of insufficient healthcare workers, particularly nurses. Reasons for this occurrence might be found in the deficiencies of their education systems, as well as the population aging of northern and western countries. As a response to this deficiency, those countries have begun intensive recruitment of foreign qualified female healthcare workers, which has led to the point that nurse migration today presents a very intense, and by many accounts specific migration flow. Female migrating work force is often in pursuit of low-wage and lowqualified work. Nurse migration is actually an example of motion of qualified female migrants in pursuit for better employment opportunities. While such a way of filling up the vacant positions works for the “importing” countries as a temporary solution, departure of trained female personnel presents a significant loss for the originating countries. In this paper we pay special attention to the countries who are the main “importers”, but also to those who are “exporters” of nursing personnel, and to specific national strategies these countries have applied.

  9. Epidemic spread in coupled populations with seasonally varying migration rates

    Science.gov (United States)

    Muzyczyn, Adam; Shaw, Leah B.

    2009-03-01

    The H5N1 strain of avian influenza has spread worldwide, and this spread may be due to seasonal migration of birds and mixing of birds from different regions in the wintering grounds. We studied a multipatch model for avian influenza with seasonally varying migration rates. The bird population was divided into two spatially distinct patches, or subpopulations. Within each patch, the disease followed the SIR (susceptible-infected-recovered) model for epidemic spread. Migration rates were varied periodically, with a net flux toward the breeding grounds during the spring and towards the wintering grounds during the fall. The case of two symmetric patches reduced to single-patch SIR dynamics. However, asymmetry in the birth and contact rates in the breeding grounds and wintering grounds led to bifurcations to longer period orbits and chaotic dynamics. We studied the bifurcation structure of the model and the phase relationships between outbreaks in the two patches.

  10. Temporary and circular labour migration and codevelpment: a case estudy

    Directory of Open Access Journals (Sweden)

    Elena Sánchez-Montijano

    2012-05-01

    Full Text Available The search for new ways to manage international migration is one of the main topics at the current political agendas. Within this framework, Temporary and Circular Labour Migration (TCLM as a way of fl ow management on the one hand, and co-development as a set of actions that seek to articulate migration and development on the other, have recently been promoted as double win situations. Both initiatives depart from the assumption that migrants can make important contributions to development, in their countries of destination but also in their countries of origin. The paper explores the opportunities and difficulties that arise when a single initiative attempts tobring together these two types of activities, which have so far been managed by different entities and in separated venues. The study raises the question about the positive and negative effects of this alliance. The article presents the results of a TCLM case study.

  11. Carbon cycle

    Energy Technology Data Exchange (ETDEWEB)

    Jaeger, J; Halbritter, G; Neumann-Hauf, G

    1982-05-01

    This report contains a review of literature on the subjects of the carbon cycle, the increase of the atmospheric CO/sub 2/ concentration and the possible impacts of an increased CO/sub 2/ concentration on the climate. In addition to this survey, the report discusses the questions that are still open and the resulting research needs. During the last twenty years a continual increase of the atmospheric carbon dioxide concentration by about 1-2 ppm per years has been observed. In 1958 the concentration was 315 ppm and this increased to 336 ppm in 1978. A rough estimate shows that the increase of the atmospheric carbon dioxide concentration is about half of the amount of carbon dioxide added to the atmosphere by the combustion of fossil fuels. Two possible sinks for the CO/sub 2/ released into the atmosphere are known: the ocean and the biota. The role of the biota is, however, unclear, since it can act both as a sink and as a source. Most models of the carbon cycle are one-dimensional and cannot be used for accurate predictions. Calculations with climate models have shown that an increased atmospheric CO/sub 2/ concentration leads to a warming of the earth's surface and lower atmosphere. Calculations show that a doubling of the atmospheric CO/sub 2/-concentration would lead to a net heating of the lower atmosphere and earth's surface by a global average of about 4 W m/sup -2/. Greater uncertainties arise in estimating the change in surface temperature resulting from this change in heating rate. It is estimated that the global average annual surface temperature would change between 1.5 and 4.5 K. There are, however, latitudinal and seasonal variations of the impact of increased CO/sub 2/ concentration. Other meteorological variables (e.g. precipitation, wind speed etc.) would also be changed. It appears that the impacts of the other products of fossil fuel combustion are unlikely to counteract the impacts of CO/sub 2/ on the climate.

  12. Your Menstrual Cycle

    Science.gov (United States)

    ... your menstrual cycle What happens during your menstrual cycle The menstrual cycle includes not just your period, but the rise ... that take place over the weeks in your cycle. Want to know what happens on each day ...

  13. Protocols for Migration and Invasion Studies in Prostate Cancer.

    Science.gov (United States)

    van de Merbel, Arjanneke F; van der Horst, Geertje; Buijs, Jeroen T; van der Pluijm, Gabri

    2018-01-01

    Prostate cancer is the most common malignancy diagnosed in men in the western world. The development of distant metastases and therapy resistance are major clinical problems in the management of prostate cancer patients. In order for prostate cancer to metastasize to distant sites in the human body, prostate cancer cells have to migrate and invade neighboring tissue. Cancer cells can acquire a migratory and invasive phenotype in several ways, including single cell and collective migration. As a requisite for migration, epithelial prostate cancer cells often need to acquire a motile, mesenchymal-like phenotype. This way prostate cancer cells often lose polarity and epithelial characteristics (e.g., expression of E-cadherin homotypic adhesion receptor), and acquire mesenchymal phenotype (for example, cytoskeletal rearrangements, enhanced expression of proteolytic enzymes and other repertory of integrins). This process is referred to as epithelial-to-mesenchymal transition (EMT). Cellular invasion, one of the hallmarks of cancer, is characterized by the movement of cells through a three-dimensional matrix, resulting in remodeling of the cellular environment. Cellular invasion requires adhesion, proteolysis of the extracellular matrix, and migration of cells. Studying the migratory and invasive ability of cells in vitro represents a useful tool to assess the aggressiveness of solid cancers, including those of the prostate.This chapter provides a comprehensive description of the Transwell migration assay, a commonly used technique to investigate the migratory behavior of prostate cancer cells in vitro. Furthermore, we will provide an overview of the adaptations to the Transwell migration protocol to study the invasive capacity of prostate cancer cells, i.e., the Transwell invasion assay. Finally, we will present a detailed description of the procedures required to stain the Transwell filter inserts and quantify the migration and/or invasion.

  14. Rural migration and health care

    DEFF Research Database (Denmark)

    Svendsen, Gunnar Lind Haase; Jensen, Marit Vatn

    This literature study focuses on possible links between access to health services and migration in rural areas. Why do people move to or from rural areas or why do they stay? What determines where people settle? And, in this context, do local health care services play an important or minor role......, or no role at all? First, the paper reports on key findings from rural migration studies, in order to shed light on two migration trends: urbanization and counter-urbanization. Then we take a closer look on settlement preferences in rural areas, including the impact of health care facilities. Finally, we end...... up with a more deepgoing review of the relatively small number of studies, which explicitly deal with settlement preferences related to access to health care....

  15. Migration and the Wage Curve:

    DEFF Research Database (Denmark)

    Brücker, Herbert; Jahn, Elke J.

    in a general equilibrium framework. For the empirical analysis we employ the IABS, a two percent sample of the German labor force. We find that the elasticity of the wage curve is particularly high for young workers and workers with a university degree, while it is low for older workers and workers......  Based on a wage curve approach we examine the labor market effects of migration in Germany. The wage curve relies on the assumption that wages respond to a change in the unemployment rate, albeit imperfectly. This allows one to derive the wage and employment effects of migration simultaneously...... with a vocational degree. The wage and employment effects of migration are moderate: a 1 percent increase in the German labor force through immigration increases the aggregate unemployment rate by less than 0.1 percentage points and reduces average wages by less 0.1 percent. While native workers benefit from...

  16. Focus: Asian migration to Canada.

    Science.gov (United States)

    Kobayashi, A

    1988-01-01

    This collection of 5 short essays on Asian migration to Canada focuses on the relationships between individual migrants and their social contexts, both Asian and Canadian. Papers by Anderson and Kobayashi adopt research perspectives of outsider and insider, respectively. Vibert provides a historical overview against which the substantive issues introduced in the other 3 papers can be understood, and he illustrates the links between circumstances of migration and the larger issues by which the course of Canadian social progress has been steered. Mercer provides an introduction to issues that dominate the agenda of contemporary research, to show that Canadian communities of Asian heritage continue to grow in size, diversity, and complexity, as they become more established on the Canadian landscape. This collection is as much about the geography of racism as it is about migration.

  17. Families, children, migration and AIDS.

    Science.gov (United States)

    Haour-Knipe, Mary

    2009-01-01

    Migration is very often a family affair, and often involves children, directly or indirectly. It may give rise to better quality of life for an entire family, or to bitter disappointment, and may also increase vulnerability to HIV and AIDS. This review, carried out for the Joint Learning Initiative on Children and AIDS, links the literature on "migration", on "HIV and AIDS" and on "families". Three themes are sketched: (1) As both HIV prevalence and circular migration increase, former migrant workers affected by AIDS may return to their families for care and support, especially at the end of life, often under crisis conditions. Families thus lose promising members, as well as sources of support. However, very little is known about the children of such migrants. (2) Following patterns of migration established for far different reasons, children may have to relocate to different places, sometimes over long distances, if their AIDS-affected parents can no longer care for them. They face the same adaptation challenges as other children who move, but complicated by loss of parent(s), AIDS stigma, and often poverty. (3) The issue of migrant families living with HIV has been studied to some extent, but mainly in developed countries with a long history of migration, and with little attention paid to the children in such families. Difficulties include involuntary separation from family members, isolation and lack of support, disclosure and planning for children's care should the parent(s) die and differences in treatment access within the same family. Numerous research and policy gaps are defined regarding the three themes, and a call is made for thinking about migration, families and AIDS to go beyond description to include resilience theory, and to go beyond prevention to include care.

  18. Effects of TNF-alpha on Endothelial Cell Collective Migration

    Science.gov (United States)

    Chen, Desu; Wu, Di; Helim Aranda-Espinoza, Jose; Losert, Wolfgang

    2013-03-01

    Tumor necrosis factor (TNF-alpha) is a small cell-signaling protein usually released by monocytes and macrophages during an inflammatory response. Previous work had shown the effects of TNF-alpha on single cell morphology, migration, and biomechanical properties. However, the effect on collective migrations remains unexplored. In this work, we have created scratches on monolayers of human umbilical endothelial cells (HUVECs) treated with 25ng/mL TNF-alpha on glass substrates. The wound healing like processes were imaged with phase contrast microscopy. Quantitative analysis of the collective migration of cells treated with TNF-alpha indicates that these cells maintain their persistent motion and alignment better than untreated cells. In addition, the collective migration was characterized by measuring the amount of non-affine deformations of the wound healing monolayer. We found a lower mean non-affinity and narrower distribution of non-affinities upon TNF-alpha stimulation. These results suggest that TNF-alpha introduces a higher degree of organized cell collective migration.

  19. Migration and Deforestation in Indonesia

    OpenAIRE

    Rivayani Darmawan; Stephan Klasen; Nunung Nuryartono

    2015-01-01

    Indonesia now has the highest deforestation rate in the world, with an average increase of about 47,600 ha per year. As a result, the nation is one of the largest emitters of greenhouse gases in the world and is putting its rich biodiversity at risk. Although the literature discussing the political economy of Indonesia commercial's logging is growing, only a small amount focuses on the relation-ship between migration and deforestation. Migration may contribute to the forest cover change, as m...

  20. Voluntary income redistribution with migration.

    Science.gov (United States)

    Crane, R

    1992-01-01

    This study is concerned with the welfare magnet problem, in which disparities in transfer policies across states are believed to encourage recipient and possibly resource migration. "This study clarifies the terms of the debate by showing how the value of redistributing local resources depends not only on the value of income to each group, but also on the cost of the transfer in erosion of the resource base through migration and through the general equilibrium effects of such activity on local prices." The geographical focus is on the United States. excerpt

  1. Women’s football migration

    DEFF Research Database (Denmark)

    Agergaard, Sine

    What is intriguing about women’s football as a cultural phenomenon is that unlike men’s football the finances and media interest for the game are sparse. Nevertheless we have found that migration of female football players is growing steadily and women’s football is becoming global in nature....... The question is then what drives this globalization process? According to our study of women’s football migration into Scandinavia, one of the centers of women’s football, transnational networks play a crucial role in mobilizing global migratory moves. Using the concept of friends-of-friends networks from Bale...

  2. Retirement migration and military retirement

    International Nuclear Information System (INIS)

    1988-06-01

    This report addresses questions relevant to a socioeconomic assessment system for southern Nevada. They point to an understanding of the magnitude of impacts which may occur if the Yucca Mountain Project were to affect the decision-making process which leads these groups to migrate to southern Nevada. This is an important but somewhat elusive topic lacking in standard data sources. However, the topic may be addressed and analyzed systematically. This report presents the results of efforts to develop a data base and begin development of a model to address the migration, income and expenditure dimensions of these groups. 1 fig., 62 tabs

  3. Automation of Flexible Migration Workflows

    Directory of Open Access Journals (Sweden)

    Dirk von Suchodoletz

    2011-03-01

    Full Text Available Many digital preservation scenarios are based on the migration strategy, which itself is heavily tool-dependent. For popular, well-defined and often open file formats – e.g., digital images, such as PNG, GIF, JPEG – a wide range of tools exist. Migration workflows become more difficult with proprietary formats, as used by the several text processing applications becoming available in the last two decades. If a certain file format can not be rendered with actual software, emulation of the original environment remains a valid option. For instance, with the original Lotus AmiPro or Word Perfect, it is not a problem to save an object of this type in ASCII text or Rich Text Format. In specific environments, it is even possible to send the file to a virtual printer, thereby producing a PDF as a migration output. Such manual migration tasks typically involve human interaction, which may be feasible for a small number of objects, but not for larger batches of files.We propose a novel approach using a software-operated VNC abstraction layer in order to replace humans with machine interaction. Emulators or virtualization tools equipped with a VNC interface are very well suited for this approach. But screen, keyboard and mouse interaction is just part of the setup. Furthermore, digital objects need to be transferred into the original environment in order to be extracted after processing. Nevertheless, the complexity of the new generation of migration services is quickly rising; a preservation workflow is now comprised not only of the migration tool itself, but of a complete software and virtual hardware stack with recorded workflows linked to every supported migration scenario. Thus the requirements of OAIS management must include proper software archiving, emulator selection, system image and recording handling. The concept of view-paths could help either to automatically determine the proper pre-configured virtual environment or to set up system

  4. Combining turbine blade-strike and life cycle models to assess mitigation strategies for fish passing dams

    Energy Technology Data Exchange (ETDEWEB)

    Ferguson, J.W. [National Marine Fisheries Service, Seattle, WA (United States). Fish Ecology Div.; Swedish Univ. of Agricultural Sciences, Umea (Sweden). Dept. of Wildlife, Fish and Environmental Studies; Ploskey, G.R. [Battelle-Pacific Northwest National Laboratory, Richland, WA (United States); Zabel, R.W. [National Marine Fisheries Service, Seattle, WA (United States). Fish Ecology Div.; Lundqvist, H. [Swedish Univ. of Agricultural Sciences, Umea (Sweden). Dept. of Wildlife, Fish and Environmental Studies

    2008-08-15

    Many diadromous and resident fish populations migrate within riverine, freshwater, and marine habitats that have been altered by human activities. This paper developed a tool designed to analyze the effects of dams on fish populations. The model combined a blade-strike model of a hydroelectric turbine and a life cycle model in order to generate point estimates of mortality and incorporate dam passage impacts. The modelling tool was used to study populations of Atlantic salmon and sea trout populations in Sweden which were depressed due to damming, dredging, pollution, and siltation of the rivers. The downstream migrating fish in the rivers passed through a single dam and power station containing Kaplan and Francis turbines. A blade-strike model was developed as the primary mechanism of mortality for the fish. The mortality of juvenile and adult fish and mortality rates from blade-strikes were then entered into salmon life cycle models that incorporated life history variability in age of reproduction and spawning activities. The life cycle model populations in the river were then modelled in hypothetical scenarios. Results of the scenarios were compared with effects from the blade-strike mortality results. Results of the study showed that increases in the number of female salmon escaping above the dam after 20 years was significantly higher when both juveniles and adult fish populations were protected. The model will be used to evaluate strategies designed to conserve fish populations impacted by dams. 49 refs., 9 tabs., 6 figs.

  5. Combining turbine blade-strike and life cycle models to assess mitigation strategies for fish passing dams

    International Nuclear Information System (INIS)

    Ferguson, J.W.; Zabel, R.W.; Lundqvist, H.

    2008-01-01

    Many diadromous and resident fish populations migrate within riverine, freshwater, and marine habitats that have been altered by human activities. This paper developed a tool designed to analyze the effects of dams on fish populations. The model combined a blade-strike model of a hydroelectric turbine and a life cycle model in order to generate point estimates of mortality and incorporate dam passage impacts. The modelling tool was used to study populations of Atlantic salmon and sea trout populations in Sweden which were depressed due to damming, dredging, pollution, and siltation of the rivers. The downstream migrating fish in the rivers passed through a single dam and power station containing Kaplan and Francis turbines. A blade-strike model was developed as the primary mechanism of mortality for the fish. The mortality of juvenile and adult fish and mortality rates from blade-strikes were then entered into salmon life cycle models that incorporated life history variability in age of reproduction and spawning activities. The life cycle model populations in the river were then modelled in hypothetical scenarios. Results of the scenarios were compared with effects from the blade-strike mortality results. Results of the study showed that increases in the number of female salmon escaping above the dam after 20 years was significantly higher when both juveniles and adult fish populations were protected. The model will be used to evaluate strategies designed to conserve fish populations impacted by dams. 49 refs., 9 tabs., 6 figs

  6. [International migration in the Middle East].

    Science.gov (United States)

    Beauge, G

    1985-01-01

    This special issue contains a selection of 12 papers by various authors on aspects of international migration to the Middle East. Papers are included on the impact of migration on socioeconomic development, income distribution, and rural capitalization in Egypt; migration from rural Lebanon; the effect of emigration on Pakistan; Indian workers in Oman; inter-Arab migration and development; the role of the state in migration in the Arab peninsula; the dynamics of manpower in Kuwait; the Iraqi model and Arab unity; and the impact of this migration on the concept of the New Economic Order.

  7. Labour Force Migration Effects within European Union

    Directory of Open Access Journals (Sweden)

    Carmen Mihaela Tudorache

    2006-10-01

    Full Text Available Within the EU, there is no common policy on migration; there are common policies on certain aspects of migration. The Member States fear of migration, but their economies and societies will further need migrant workers. Labour force migration have positive, but also negative consequences for all parties involved: receiving countries, origin countries and migrant workers. Within this framework, a common approach of the migration management and the harmonization of the economic migration policies of the Member States represent already one of the most important challenges for the European Union and will be further emphasized.

  8. The possibilities of least-squares migration of internally scattered seismic energy

    KAUST Repository

    Aldawood, Ali

    2015-05-26

    Approximate images of the earth’s subsurface structures are usually obtained by migrating surface seismic data. Least-squares migration, under the single-scattering assumption, is used as an iterative linearized inversion scheme to suppress migration artifacts, deconvolve the source signature, mitigate the acquisition fingerprint, and enhance the spatial resolution of migrated images. The problem with least-squares migration of primaries, however, is that it may not be able to enhance events that are mainly illuminated by internal multiples, such as vertical and nearly vertical faults or salt flanks. To alleviate this problem, we adopted a linearized inversion framework to migrate internally scattered energy. We apply the least-squares migration of first-order internal multiples to image subsurface vertical fault planes. Tests on synthetic data demonstrated the ability of the proposed method to resolve vertical fault planes, which are poorly illuminated by the least-squares migration of primaries only. The proposed scheme is robust in the presence of white Gaussian observational noise and in the case of imaging the fault planes using inaccurate migration velocities. Our results suggested that the proposed least-squares imaging, under the double-scattering assumption, still retrieved the vertical fault planes when imaging the scattered data despite a slight defocusing of these events due to the presence of noise or velocity errors.

  9. The possibilities of least-squares migration of internally scattered seismic energy

    KAUST Repository

    Aldawood, Ali; Hoteit, Ibrahim; Zuberi, Mohammad; Turkiyyah, George; Alkhalifah, Tariq Ali

    2015-01-01

    Approximate images of the earth’s subsurface structures are usually obtained by migrating surface seismic data. Least-squares migration, under the single-scattering assumption, is used as an iterative linearized inversion scheme to suppress migration artifacts, deconvolve the source signature, mitigate the acquisition fingerprint, and enhance the spatial resolution of migrated images. The problem with least-squares migration of primaries, however, is that it may not be able to enhance events that are mainly illuminated by internal multiples, such as vertical and nearly vertical faults or salt flanks. To alleviate this problem, we adopted a linearized inversion framework to migrate internally scattered energy. We apply the least-squares migration of first-order internal multiples to image subsurface vertical fault planes. Tests on synthetic data demonstrated the ability of the proposed method to resolve vertical fault planes, which are poorly illuminated by the least-squares migration of primaries only. The proposed scheme is robust in the presence of white Gaussian observational noise and in the case of imaging the fault planes using inaccurate migration velocities. Our results suggested that the proposed least-squares imaging, under the double-scattering assumption, still retrieved the vertical fault planes when imaging the scattered data despite a slight defocusing of these events due to the presence of noise or velocity errors.

  10. Measuring attitudes towards unauthorized migration

    NARCIS (Netherlands)

    van der Veer, C.G.; Ommundsen, R.; Krumov, K.; Van Le, H.; Larsen, K.S.

    2008-01-01

    This study reports on the development and cross-national utility of a Likert type scale measuring attitudes toward unauthorized migration into a foreign country in two samples from "migrant-sending" nations. In the first phase a pool of 86 attitude statements were administered to a sample of 505

  11. Convergence and migration among provinces.

    Science.gov (United States)

    Helliwell, J F

    1996-04-01

    "Have regional disparities in Canada changed over the past thirty years? This paper assesses the robustness of earlier findings of convergence in the levels and growth rates of provincial per capita GDP, and then estimates the extent to which interprovincial and international migration is being influenced by regional differences in incomes and employment." excerpt

  12. Job Migration: A Collaborative Effort

    Science.gov (United States)

    Wagoner, Cynthia L.

    2012-01-01

    Music teachers often change jobs several times during their careers. Reasons for job changes vary, but regardless, these changes bring a different set of challenges. Sharing knowledge and learning are part and parcel of collaboration. So what if, as education professionals, music teachers decided to collaborate during job migrations? For all music…

  13. Migration monitoring with automated technology

    Science.gov (United States)

    Rhonda L. Millikin

    2005-01-01

    Automated technology can supplement ground-based methods of migration monitoring by providing: (1) unbiased and automated sampling; (2) independent validation of current methods; (3) a larger sample area for landscape-level analysis of habitat selection for stopover, and (4) an opportunity to study flight behavior. In particular, radar-acoustic sensor fusion can...

  14. [Migration of dentists within Hungary].

    Science.gov (United States)

    Balázs, Péter

    2010-09-01

    Concerning the human resource management in the health care, Hungarian analysts focus mainly on cross-national migration, which was instigated considerably by joining the European Union in 2004. Contrasted to other health care professionals, dentists emphasized also the importance of in-country migration (mobility) indicating serious dangers of developing inequalities in the dental service. From the point of view of health system planning, the main problem is to balance the needs and the number of professionals in regions and areas with extremely different socio-economic conditions. Under dictatorial governments, this "balancing" (which was experienced also in Hungary) is a forced allocation of young professionals to the target regions. In political freedom and free market economy, these measures are unthinkable. The present domestic area distribution, concerning also the supply through vacancies by old age inactivity and cross-national migration, is ruled by personal decisions of actually graduated and immigrant professionals respectively. Therefore, it is unavoidable to investigate the interrelation of factors (dentists' births place, study migration and decisions for practice allocation) ruling the in-country geographic patterns of dental practices. This evidence-based knowledge can only explain the present situation and provide guidelines for health policy decision makers.

  15. Liquid chromatography in migration studies

    International Nuclear Information System (INIS)

    Carlsen, L.; Batsberg, W.

    1982-01-01

    Liquid chromatography ahs been suggested as a facile experimental technique to determine important physico-chemical properties, as permeability, porosity, dispersion-, diffusion-, and sorption charcteristics for geological material as chalk samples. The feasibility of the trechnique as a rapid method to evaluate the possible influence of changes in ground water composition on the migration behavior of radionuclides has been demonstrated

  16. Marriage migration in the Netherlands

    NARCIS (Netherlands)

    Leen Sterckx; Jaco Dagevos; Willem Huijnk; Jantine van Lisdonk

    2014-01-01

    Original title: Huwelijksmigratie in Nederland When a man or woman living in the Netherlands embarks on a relationship with a partner from another country and the couple decide to build a married life together in the Netherlands, we call this marriage migration. The foreign partner who moves to

  17. Migration of accreting giant planets

    Science.gov (United States)

    Crida, A.; Bitsch, B.; Raibaldi, A.

    2016-12-01

    We present the results of 2D hydro simulations of giant planets in proto-planetary discs, which accrete gas at a more or less high rate. First, starting from a solid core of 20 Earth masses, we show that as soon as the runaway accretion of gas turns on, the planet is saved from type I migration : the gap opening mass is reached before the planet is lost into its host star. Furthermore, gas accretion helps opening the gap in low mass discs. Consequently, if the accretion rate is limited to the disc supply, then the planet is already inside a gap and in type II migration. We further show that the type II migration of a Jupiter mass planet actually depends on its accretion rate. Only when the accretion is high do we retrieve the classical picture where no gas crosses the gap and the planet follows the disc spreading. These results impact our understanding of planet migration and planet population synthesis models. The e-poster presenting these results in French can be found here: L'e-poster présentant ces résultats en français est disponible à cette adresse: http://sf2a.eu/semaine-sf2a/2016/posterpdfs/156_179_49.pdf.

  18. Les questions de migrations internationales

    Science.gov (United States)

    Samman, Mouna Liliane

    1993-03-01

    International migrations have growing implications for both countries of origin and countries of destination. In the latter, the presence of foreigners and of members of their families today creates problems of integration, causes argument and brings mounting xenophobia. Paralleling political, economic and social measures taken by public authorities to respond to these difficulties, education needs to assist in defusing the resulting social tensions by preparing the minds of learners and helping to develop new attitudes. In particular, when educational programmes address questions of international migration, these should be treated in the framework of historical evolution so that their real significance and their true temporal and spatial dimensions become apparent. It is also important that the growing interdependence between countries should be made plain, that national history should be placed in its international context, and that the true consequences of these developments should be made clear. In this context, learners need to be acquainted with Human Rights, thereby stressing universal moral values and the role of the individual. Lastly, questions relating to international migration are usually presented in the media in a selective and partial manner, and the young people who take in this information often accept the hasty judgments which are made of situations as proven facts. This is why all teaching about international migration needs to be considered or reconsidered in the light of the complementary or competing actions of the media.

  19. [Haitian migration to Santo Domingo].

    Science.gov (United States)

    Latortue, P R

    1985-01-01

    This work examines the history of Haitian migration to the Dominican Republic, the central role of Haitian migration in Dominican society, working conditions of Haitian migrants in the Dominican Republic, and the relationship of the migration to economic development on the island of Hispaniola. Lack of data, the difficulty of measuring illegal movement, and the problem of defining Haitians in Santo Domingo have impeded understanding of migration to the Dominican Republic. It is believed by many authorities that Haitian migration to Santo Domingo is considerable and perhaps exceeds that to the US. Haitian migration to the Dominican Republic began after 1915 with the fall of the Haitian president, a worsening of economic conditions partly caused by stagnation in the agricultural sector, and the newly dominant role of the US in Haitian economic affairs. The Great Depression of the 1930s was a direct antecedent of the massacre of Haitians by Dominican police in which some 30 thousand persons were killed; the economic recession of the early 1980s has also caused an outburst of antiHaitian feeling in the Dominican Republic although 80% of laborers in the sugar industry are Haitians. Sugar is extremely important to the Dominican economy: in 1974, sugar covered 12% of cultivated land, produced 40% of foreign exchange earnings, and was responsable for 21% of taxable income. Dominicans however refuse to work in sugar plantations under the current technological. conditions and wage system. Although the government periodically demands the Dominicanization of the sugar work force, no such changes have been made. Sugar will probably continue to play a decisive role in the generation of foreign exchange despite introduction of more technologically advanced sectors which benefit from better prices in the international market. Possibilities of mechanizing sugar production in the Dominican Republic appear remote, and failure to modernize an important sector of the economy has

  20. Sedimentary record of erg migration

    Science.gov (United States)

    Porter, M. L.

    1986-06-01

    The sedimentary record of erg (eolian sand sea) migration consists of an idealized threefold division of sand-sea facies sequences. The basal division, here termed the fore-erg, is composed of a hierarchy of eolian sand bodies contained within sediments of the flanking depositional environment. These sand bodies consist of eolian strata deposited by small dune complexes, zibars, and sand sheets. The fore-erg represents the downwind, leading edge of the erg and records the onset of eolian sedimentation. Basin subsidence coupled with erg migration places the medial division, termed the central erg, over the fore-erg strata. The central erg, represented by a thick accumulation of large-scale, cross-stratified sandstone, is the product of large draa complexes. Eolian influence on regional sedimentation patterns is greatest in the central erg, and most of the sand transported and deposited in the erg is contained within this region. Reduction in sand supply and continued erg migration will cover the central-erg deposits with a veneer of back-erg deposits. This upper division of the erg facies sequence resembles closely the fore-erg region. Similar types of eolian strata are present and organized in sand bodies encased in sediments of the upwind flanking depositional environment(s). Back-erg deposits may be thin due to limited eolian influence on sedimentation or incomplete erg migration, or they may be completely absent because of great susceptibility to postdepositional erosion. Tectonic, climatic, and eustatic influences on sand-sea deposition will produce distinctive variations or modifications of the idealized erg facies sequence. The resulting variants in the sedimentary record of erg migration are illustrated with ancient examples from western North America, Europe, southern Africa, and South America.

  1. [Migration patterns of health professionals].

    Science.gov (United States)

    Kingma, Mireille

    2005-01-01

    The past three decades have seen the number of international migrants double, to reach the unprecedented total of 175 million people in 2003. National health systems are often the biggest national employer, responsible for an estimated 35 million workers worldwide. Health professionals are part of the expanding global labour market. Today, foreign-educated health professionals represent more than a quarter of the medical and nursing workforces of Australia, Canada, the United Kingdom and the United States. Destination countries, however, are not limited to industrialised nations. For example, 50 per cent of physicians in the Namibia public services are expatriates and South Africa continues to recruit close to 80% of its rural physicians from other countries. International migration often imitates patterns of internal migration. The exodus from rural to urban areas, from lower to higher income urban neighbourhoods and from lower-income to higher-income sectors contributes challenges to the universal coverage of the population. International migration is often blamed for the dramatic health professional shortages witnessed in the developing countries. A recent OECD study, however, concludes that many registered nurses in South Africa (far exceeding the number that emigrate) are either inactive or unemployed. These dire situations constitute a modern paradox which is for the most part ignored. Shared language, promises of a better quality of life and globalization all support the continued existence of health professionals' international migration. The ethical dimension o this mobility is a sensitive issue that needs to be addressed. A major paradigm shift, however, is required in order to lessen the need to migrate rather than artificially curb the flows.

  2. Mediterranean Migrations: Regionalisms Versus Globalisation

    Directory of Open Access Journals (Sweden)

    Martin Baldwin-Eduards

    2004-06-01

    Full Text Available This paper challenges the claim of globalisation as a cause ofimmigration into Southern Europe and, on an empirical basis, identifies regionalisation as being the primary issue, along with networked migratory patterns. However, the changing patterns of immigration do present challenges to both state and society. It is argued here that recent policy responses in Portugal, Italy and Spain have been inconsistent and irrational – reflecting more the ‘securitisation’ of migration than European reality. Earlier policy innovations are identified, by country and date: most of these have now been abandoned. It is suggested that all of Southern Europe has converged onto a statist, restrictionist model of immigration control that was formerly held only by Greece. The principal characteristics of this model are outlined, along with a migration flowchart and indicative data for migrant flows and sub-flows in Italy and Spain. In the final section, I try to show that the needs of the economy cannot be predicted, immigration cannot becontrolled in the manner currently being enforced across Southern Europe, and attempts to do so will damage rather than improve economic productivity and growth. The concept of an accomodating immigration policy is advanced, whereby the state tries to manage the needs of both employers and potential migrants. Six guidelines for policy development are suggested – most of which have alreadybeen successfully carried out in the European Union. These are the following: migration in order to find a job; circular cross-border migration; EU level negotiation of readmission agreements; the need for a variety of migration-for-employment schemes; legal residence should not depend upon continuity of employment; and discreet legalisation will still be needed in Southern Europe.

  3. GLOBALIZATION VERSUS SEGREGATION - BUSINESS CYCLES SYNCHRONIZATION IN EUROPE

    Directory of Open Access Journals (Sweden)

    Sebastian Florian Enea

    2012-12-01

    Full Text Available Globalization and business cycles are equally elusive economic phenomena; hence they represent a continuous research possibility and a source of possible inquiries due to their complex nature. The aim of the paper is to explain the synchronization of business cycles using the relationship between the growth rate of the GDP and FDI, considered as percentage of the GDP. The results show that there is no unique European business cycle, but two cores between which countries migrate and stress out the importance of the FDI channel in business cycle transmission. The future research directions will employ fuzzy cluster techniques, used on a larger sample.

  4. Depth migration and de-migration for 3-D migration velocity analysis; Migration profondeur et demigration pour l'analyse de vitesse de migration 3D

    Energy Technology Data Exchange (ETDEWEB)

    Assouline, F.

    2001-07-01

    3-D seismic imaging of complex geologic structures requires the use of pre-stack imaging techniques, the post-stack ones being unsuitable in that case. Indeed, pre-stack depth migration is a technique which allows to image accurately complex structures provided that we have at our disposal a subsurface velocity model accurate enough. The determination of this velocity model is thus a key element for seismic imaging, and to this end, migration velocity analysis methods have met considerable interest. The SMART method is a specific migration velocity analysis method: the singularity of this method is that it does not rely on any restrictive assumptions on the complexity of the velocity model to determine. The SMART method uses a detour through the pre-stack depth migrated domain for extracting multi-offset kinematic information hardly accessible in the time domain. Once achieved the interpretation of the pre-stack depth migrated seismic data, a kinematic de-migration technique of the interpreted events enables to obtain a consistent kinematic database (i.e. reflection travel-times). Then, the inversion of these travel-times, by means of reflection tomography, allows the determination of an accurate velocity model. To be able to really image geologic structures for which the 3-D feature is predominant, we have studied the implementation of migration velocity analysis in 3-D in the context of the SMART method, and more generally, we have developed techniques allowing to overcome the intrinsic difficulties in the 3-D aspects of seismic imaging. Indeed, although formally the SMART method can be directly applied to the case of 3-D complex structures, the feasibility of its implementation requires to choose well the imaging domain. Once this choice done, it is also necessary to conceive a method allowing, via the associated de-migration, to obtain the reflection travel-times. We first consider the offset domain which constitutes, still today, the strategy most usually used

  5. Least-squares reverse time migration of multiples

    KAUST Repository

    Zhang, Dongliang

    2013-12-06

    The theory of least-squares reverse time migration of multiples (RTMM) is presented. In this method, least squares migration (LSM) is used to image free-surface multiples where the recorded traces are used as the time histories of the virtual sources at the hydrophones and the surface-related multiples are the observed data. For a single source, the entire free-surface becomes an extended virtual source where the downgoing free-surface multiples more fully illuminate the subsurface compared to the primaries. Since each recorded trace is treated as the time history of a virtual source, knowledge of the source wavelet is not required and the ringy time series for each source is automatically deconvolved. If the multiples can be perfectly separated from the primaries, numerical tests on synthetic data for the Sigsbee2B and Marmousi2 models show that least-squares reverse time migration of multiples (LSRTMM) can significantly improve the image quality compared to RTMM or standard reverse time migration (RTM) of primaries. However, if there is imperfect separation and the multiples are strongly interfering with the primaries then LSRTMM images show no significant advantage over the primary migration images. In some cases, they can be of worse quality. Applying LSRTMM to Gulf of Mexico data shows higher signal-to-noise imaging of the salt bottom and top compared to standard RTM images. This is likely attributed to the fact that the target body is just below the sea bed so that the deep water multiples do not have strong interference with the primaries. Migrating a sparsely sampled version of the Marmousi2 ocean bottom seismic data shows that LSM of primaries and LSRTMM provides significantly better imaging than standard RTM. A potential liability of LSRTMM is that multiples require several round trips between the reflector and the free surface, so that high frequencies in the multiples suffer greater attenuation compared to the primary reflections. This can lead to lower

  6. KIN NETWORKS AND MIGRATION IN SAGBAMA LOCAL ...

    African Journals Online (AJOL)

    CIU

    Historically, migration process has been characterized and continues to be .... Mexican migration to the U.S (Massey, Arango, Hugo, Kouaouci, Pellegrino and .... the study destination (Sagbama) according to Independent National Electoral.

  7. Comparative Political Economy and International Migration

    NARCIS (Netherlands)

    Afonso, A.; Devitt, C.

    2016-01-01

    This article provides an overview of the literature connecting comparative political economy and international migration in advanced industrialized countries with a focus on the relationship between labour migration, labour markets and welfare institutions. Immigration flows and policies are

  8. Individual Decisions to Migrate During Civil Conflict

    Science.gov (United States)

    Bohra-Mishra, Pratikshya; Massey, Douglas S.

    2012-01-01

    The existing literature on forced migration limits our understanding of how violence affects migration to competing destinations. This article adds to the literature on forced migration by studying how armed violence during a period of civil conflict in south-central Nepal influenced the likelihood of local, internal, and international migration. We find that violence has a nonlinear effect on migration, such that low to moderate levels of violence reduce the odds of movement, but when violence reaches high levels, the odds of movement increase. We also find that the effect of violence on mobility increases as the distance of the move increases. When we consider the influence of violence on microlevel decision-making, we find that the effects of individual and household-level determinants were mostly consistent with hypotheses derived from contemporary theories of voluntary migration and that no predictor of migration influenced the decision to migrate differently in the presence of violence. PMID:21541805

  9. Quantum thermodynamic cycles and quantum heat engines. II.

    Science.gov (United States)

    Quan, H T

    2009-04-01

    We study the quantum-mechanical generalization of force or pressure, and then we extend the classical thermodynamic isobaric process to quantum-mechanical systems. Based on these efforts, we are able to study the quantum version of thermodynamic cycles that consist of quantum isobaric processes, such as the quantum Brayton cycle and quantum Diesel cycle. We also consider the implementation of the quantum Brayton cycle and quantum Diesel cycle with some model systems, such as single particle in a one-dimensional box and single-mode radiation field in a cavity. These studies lay the microscopic (quantum-mechanical) foundation for Szilard-Zurek single-molecule engine.

  10. Computational modelling of multi-cell migration in a multi-signalling substrate

    International Nuclear Information System (INIS)

    Mousavi, Seyed Jamaleddin; Doblaré, Manuel; Doweidar, Mohamed Hamdy

    2014-01-01

    Cell migration is a vital process in many biological phenomena ranging from wound healing to tissue regeneration. Over the past few years, it has been proven that in addition to cell–cell and cell-substrate mechanical interactions (mechanotaxis), cells can be driven by thermal, chemical and/or electrical stimuli. A numerical model was recently presented by the authors to analyse single cell migration in a multi-signalling substrate. That work is here extended to include multi-cell migration due to cell–cell interaction in a multi-signalling substrate under different conditions. This model is based on balancing the forces that act on the cell population in the presence of different guiding cues. Several numerical experiments are presented to illustrate the effect of different stimuli on the trajectory and final location of the cell population within a 3D heterogeneous multi-signalling substrate. Our findings indicate that although multi-cell migration is relatively similar to single cell migration in some aspects, the associated behaviour is very different. For instance, cell–cell interaction may delay single cell migration towards effective cues while increasing the magnitude of the average net cell traction force as well as the local velocity. Besides, the random movement of a cell within a cell population is slightly greater than that of single cell migration. Moreover, higher electrical field strength causes the cell slug to flatten near the cathode. On the other hand, as with single cell migration, the existence of electrotaxis dominates mechanotaxis, moving the cells to the cathode or anode pole located at the free surface. The numerical results here obtained are qualitatively consistent with related experimental works. (paper)

  11. BWROPT: A multi-cycle BWR fuel cycle optimization code

    Energy Technology Data Exchange (ETDEWEB)

    Ottinger, Keith E.; Maldonado, G. Ivan, E-mail: Ivan.Maldonado@utk.edu

    2015-09-15

    Highlights: • A multi-cycle BWR fuel cycle optimization algorithm is presented. • New fuel inventory and core loading pattern determination. • The parallel simulated annealing algorithm was used for the optimization. • Variable sampling probabilities were compared to constant sampling probabilities. - Abstract: A new computer code for performing BWR in-core and out-of-core fuel cycle optimization for multiple cycles simultaneously has been developed. Parallel simulated annealing (PSA) is used to optimize the new fuel inventory and placement of new and reload fuel for each cycle considered. Several algorithm improvements were implemented and evaluated. The most significant of these are variable sampling probabilities and sampling new fuel types from an ordered array. A heuristic control rod pattern (CRP) search algorithm was also implemented, which is useful for single CRP determinations, however, this feature requires significant computational resources and is currently not practical for use in a full multi-cycle optimization. The PSA algorithm was demonstrated to be capable of significant objective function reduction and finding candidate loading patterns without constraint violations. The use of variable sampling probabilities was shown to reduce runtime while producing better results compared to using constant sampling probabilities. Sampling new fuel types from an ordered array was shown to have a mixed effect compared to random new fuel type sampling, whereby using both random and ordered sampling produced better results but required longer runtimes.

  12. Impact of Dose Reductions, Delays Between Chemotherapy Cycles, and/or Shorter Courses of Adjuvant Chemotherapy in Stage II and III Colorectal Cancer Patients: a Single-Center Retrospective Study.

    Science.gov (United States)

    Sgouros, Joseph; Aravantinos, Gerasimos; Kouvatseas, George; Rapti, Anna; Stamoulis, George; Bisvikis, Anastasios; Res, Helen; Samantas, Epameinondas

    2015-12-01

    Most stage II or III colorectal cancer patients are receiving nowadays a 4 to 6-month course of adjuvant chemotherapy. However, delays between cycles, reductions in the doses of chemotherapy drugs, or even permanent omissions of chemotherapy cycles might take place due to side effects or patient's preference. We examined the impact of these treatment modifications on recurrence-free survival (RFS) and overall survival (OS). We retrospectively collected data from colorectal cancer patients who had received adjuvant chemotherapy in our Department. Patients were categorized in five groups based on whether they had or not delays between chemotherapy cycles, dose reductions, and permanent omissions of chemotherapy cycles. Three-year RFS and OS of the five different groups were compared using the log-rank test and the Sidak approach. Five hundred and eight patients received treatment. Twenty seven percent of the patients had the full course of chemotherapy; the others had delays, dose reductions, or early termination of the treatment. No statistically significant differences were observed in 3-year RFS and OS between the five groups. A trend for worse RFS was noticed with early termination of treatment. A similar trend was also noticed for OS but only for stage II patients. In colorectal cancer patients, receiving adjuvant chemotherapy, delays between chemotherapy cycles, dose reductions of chemotherapy drugs, or even early termination of the treatment course do not seem to have a negative impact in 3-year RFS and OS; however, due to the trend of worse RFS in patients receiving shorter courses of chemotherapy, further studies are needed.

  13. Nanoparticles migration in fractured rocks and affects on contaminant migration

    Science.gov (United States)

    Missana, Tiziana; Garcia-Gutierrez, Miguel; Alonso, Ursula

    2014-05-01

    In previous studies, the transport behavior of artificial (gold and latex) and natural (smectite clay) colloids, within a planar fracture in crystalline rock, was analyzed. In order to better understand the effects of colloid size, shape and surface charge on nanoparticle migration and especially on filtration processes on natural rock surfaces, different clay colloids and oxide nanoparticles were selected and their transport studied as a function of the residence time. In all the cases, (a fraction of) the nanoparticles travelled in the fracture as fast as or faster than water (with a retardation factor, Rf ≤ 1) and the observed Rf, was related to the Taylor dispersion coefficient, accounting for colloid size, water velocity and fracture width. However, under most of the cases, in contrast to the behavior of a conservative tracer, colloids recovery was much lower than 100 %. Differences in recovery between different nanoparticles, under similar residence times, were analyzed. In order to evaluate the possible consequences, on contaminant migration, of the presence of nanoparticles in the system, transport tests were carried out with both colloids and sorbing radionuclides. The overall capacity for colloids of enhancing radionuclide migration in crystalline rock fractures is discussed. Acknowledgments: The research leading to these results received funding from EU FP7/2007-2011 grant agreement Nº 295487 (BELBAR, Bentonite Erosion: effects on the Long term performance of the engineered Barrier and Radionuclide Transport) and by the Spanish Government under the project NANOBAG (CTM2011-2797).

  14. Migration and Remittances Factbook 2016, Third Edition

    OpenAIRE

    World Bank Group

    2016-01-01

    The Migration and Remittances Factbook 2016 attempts to present numbers and facts behind the stories of international migration and remittances, drawing on authoritative, publicly available data. It provides a snapshot of statistics on immigration, emigration, skilled emigration, and remittance flows for 210 countries and 15 regional and income groups. The Migration and Remittances Factbook 2016 updates the 2011 edition of the Factbook with additional data on bilateral migration and remittanc...

  15. Capitalist development and internal migration in Nigeria.

    Science.gov (United States)

    Akor, R I; Mou, D

    1986-12-01

    The authors analyze internal migration trends in Nigeria by examining individual household strategies and how they have adapted to structural changes brought about by colonial rule and capitalist development. The first section of this article describes the structural changes that started the process of labor migration. The second section deals with post-independence industrialization and the consequent rural-urban migration. The final section analyzes the consequences of these migration patterns for urban growth and rural productivity.

  16. Globalization and formal sector migration in Brazil

    OpenAIRE

    Aguayo-Tellez, Ernesto; Muendler, Marc-Andreas; Poole, Jennifer Pamela

    2008-01-01

    We use novel linked employer–employee data to study the relationship between globalization and formal sector interstate migration for Brazil. We estimate the worker’s multichoice migration problem and document that previously unobserved employer covariates are significant predictors associated with migration flows. Our results provide support for the idea that globalization acts on internal migration through the growth of employment opportunities at locations with a high concentration of fore...

  17. Juridical structures: refugees and migration.

    Science.gov (United States)

    Veiter, T

    1988-01-01

    The juridical problems in regard to the concepts of refugee, expulsion, and migration are complicated. If one speaks about migration in Europe, one must 1st distinguish between Eastern and Western Europe. In the communist states of Eastern Europe the refugee problem does not exist officially, with the only existing refugee problem in Yugoslavia, which has signed and ratified the Geneva Refugee Convention of 1951. In the other East European states the right to asylum exists, but refugees are granted asylum only if they are persecuted in their country of origin for their communist ideas and activities. In speaking of migration, one must distinguish between migration, forced migration, mass migration, emigration, immigration, the shift of populations, and refugees. In the communist countries of Eastern Europe the right to emigration is not respected, although certain exceptions, as in Poland or Yugoslavia do exist. Generally, in the communist states emigration is not allowed and illegal emigration is punished as "Flight from the Republic." With a few exceptions, political and other persecutions are no longer so typical within Europe. In the last decades, the refugee problem has changed to other continents: Afghanistan/Pakistan, Iran, Sri Lanka, East Timor, Lebanon, Palestine, Sudan, Tchad, Ethiopia, Eritrea, and Angola. The refugee problem in Europe consists mainly in the large afflux of refugees coming from places with other cultural (and religious) attributes. The Islamic immigrants declare themselves regularly as political refugees and hope to be acknowledged as such by the receiving state. The fear of the governments and populations of the receiving countries is that it would not be possible to assimilate such aliens who do not belong to the Christian culture of Europe. Formerly, refugees came mostly from the Christian countries of Eastern Europe with the same race identity and the same religion. For years now, more and more foreign workers are a kind of migrant

  18. Socioeconomic context and the association between marriage and Mexico-U.S. migration.

    Science.gov (United States)

    Riosmena, Fernando

    2009-06-01

    In this paper, I analyze how the association between Mexico-U.S. migration and marriage varies across socioeconomic settings in origins. Using Mexican Migration Project data and employing bilevel survival analysis with controls for socioeconomic, migrant network, and marriage market characteristics and family size, I find that single people are most likely to migrate relative to those married in areas of recent industrialization, where the Mexican patriarchal system is weaker and economic opportunities for both men and women make post-marital migration less attractive. Marital status is not significant in agriculture-dependent areas, where the bargaining power of husbands might be higher relative to other settings; their age-profiles of earnings flatter; and remunerated female work scarcer, making migration attractive later in the life course.

  19. Socioeconomic context and the association between marriage and Mexico–U.S. migration

    Science.gov (United States)

    Riosmena, Fernando

    2009-01-01

    In this paper, I analyze how the association between Mexico–U.S. migration and marriage varies across socioeconomic settings in origins. Using Mexican Migration Project data and employing bilevel survival analysis with controls for socioeconomic, migrant network, and marriage market characteristics and family size, I find that single people are most likely to migrate relative to those married in areas of recent industrialization, where the Mexican patriarchal system is weaker and economic opportunities for both men and women make post-marital migration less attractive. Marital status is not significant in agriculture-dependent areas, where the bargaining power of husbands might be higher relative to other settings; their age-profiles of earnings flatter; and remunerated female work scarcer, making migration attractive later in the life course. PMID:19756216

  20. MIGRATIONS OF RELEASED SEISMIC ENERGY IN VARIOUS GEODYNAMIC CONDITIONS

    Directory of Open Access Journals (Sweden)

    A. V. Novopashina

    2018-01-01

    Full Text Available The properties of slow seismic activity migration have been revealed by the space-time analysis of the total earthquake energy (LgEsum. Our study of seismic activity covers the fragments of  the Central Asian, Pacific and Alpine seismic belts: the Baikal rift system (BRS, Russia, the San Andreas fault zone (California, USA, the Christchurch fault (New Zealand, the North and East Anatolian faults (Turkey, the Philippine subduction zone, and the central fragment of the Mid-Atlantic oceanic ridge. The chains of LgEsum clusters mark the propagation of the maximum stresses front in the weaker crust areas, the zones of fault dynamic influence, and the regions of conjugated tectonic structures. The migration process is characterized by a periodicity, changes in direction, and similar modular values of the migration rates within a single fault segment (or a fault zone, which is probably related to the mechanical and rheological crust and upper mantle properties. The data analysis shows that a strong earthquake source may occur at a location wherein the front of seismic activity propagates with periodical changes in direction, and such a source can develop within a period that is multiple of the migration fluctuations, probably associated with the influence of external periodic factors. The main periods of migration fluctuations (2–4 years, and 9–13 years, in different ratios are present in the seismic regimes of different seismic belts. The migration rate, as well as the propagation velocity of the maximum stresses front, directly depends on the velocity of movements between the plates in the region.

  1. [Urban employment and internal migration in Peru].

    Science.gov (United States)

    Cotlear, D

    1984-06-01

    The relationship between internal migration and employment problems in Peru is examined. The author argues that regional differences in income distribution are the primary causes of migration, particularly to urban areas. A model of the migration process is developed and tested using data from official sources, surveys, and the published literature.

  2. QUALIFIED VERSION OF MIGRATION: BRAIN DRAIN

    OpenAIRE

    Ayhan GENCLER

    2009-01-01

    Though globalization suggests an international exchange of people besides goods and capital, developed countries often tended to put forward some restrictions on the migration of workers from developed countries. However, there has been an increase in skilled international migration especially during the last two decades. Skilled international migration or brain drain points out the emigration of educated and highly skilled workers. It seems tha...

  3. Migration Flows: Measurement, Analysis and Modeling

    NARCIS (Netherlands)

    Willekens, F.J.; White, Michael J.

    2016-01-01

    This chapter is an introduction to the study of migration flows. It starts with a review of major definition and measurement issues. Comparative studies of migration are particularly difficult because different countries define migration differently and measurement methods are not harmonized.

  4. Thermal-gradient migration of brine inclusions in salt crystals

    International Nuclear Information System (INIS)

    Yagnik, S.K.

    1982-09-01

    It has been proposed that high-level nuclear waste be disposed in a geologic repository. Natural-salt deposits, which are being considered for this purpose, contain a small volume fraction of water in the form of brine inclusions distributed throughout the salt. Radioactive-decay heating of the nuclear wastes will impose a temperature gradient on the surrounding salt which mobilizes the brine inclusions. Inclusions filled completely with brine migrate up the temperature gradient and eventually accumulate brine near the buried waste forms. The brine may slowly corrode or degrade the waste forms which is undesirable. In this work, thermal gradient migration of both all-liquid and gas-liquid inclusions was experimentally studied in synthetic single crystals of NaCl and KCl using a hot-stage attachment to an optical microscope which was capable of imposing temperature gradients and axial compressive loads on the crystals. The migration velocities of the inclusions were found to be dependent on temperature, temperature gradient, and inclusion shape and size. The velocities were also dictated by the interfacial mass transfer resistance at brine/solid interface. This interfacial resistance depends on the dislocation density in the crystal, which in turn, depends on the axial compressive loading of the crystal. At low axial loads, the dependence between the velocity and temperature gradient is non-linear.At high axial loads, however, the interfacial resistance is reduced and the migration velocity depends linearly on the temperature gradient. All-liquid inclusions filled with mixed brines were also studied. For gas-liquid inclusions, three different gas phases (helium, air and argon) were compared. Migration studies were also conducted on single crystallites of natural salt as well as in polycrystalline natural salt samples. The behavior of the inclusions at large angle grain boundaries was observed. 35 figures, 3 tables

  5. Thermal gradient migration of brine inclusions in salt crystals

    International Nuclear Information System (INIS)

    Yagnik, S.K.

    1982-01-01

    Natural salt deposits, which are being considered for high-level nuclear wastes repositories, contain a small volume fraction of water in the form of brine inclusions distributed throughout the salt. Radioactive decay heating of the nuclear wastes will impose a temperature gradient on the surrounding salt which mobilizes the brine inclusions. Inclusions filled completely with brine (the all-liquid inclusions) migrate up the temperature gradient and eventually accumulate brine near the buried waste forms. The brine may slowly corrode or degrade the waste forms which is undesirable. In the present work, thermal gradient migration of both all-liquid and gas-liquid inclusions was experimentally studied in synthetic single crystals of NaCl and KCl using a hot-stage attachment to an optical microscope which was capable of imposing temperature gradients and axial compressive loads on the crystals. The migration velocities of the inclusions were found to be dependent on temperature, temperature gradient, and inclusion shape and size. The velocities were also dictated by the interfacial mass transfer resistance at brine/solid interface. This interfacial resistance depends on the dislocation density in the crystal, which in turn, depends on the axial compressive loading of the crystal. At low axial loads, the dependence between the velocity and temperature gradient is nonlinear. At high axial loads, however, the interfacial resistance is reduced and the migration velocity depends linearly on the temperature gradient. All-liquid inclusions filled with mixed brines were also studied. For gas-liquid inclusions, three different gas phases (helium, air and argon) were compared. Migration studies were also conducted on single crystallites of natural salt as well as in polycrystalline natural salt samples. The behavior of the inclusions at large angle grain boudaries was observed

  6. Tracer migration experiments in the Stripa mine 1980-1991

    International Nuclear Information System (INIS)

    Birgersson, L.; Widen, H.; Aagren, T.; Neretnieks, I.

    1992-05-01

    During more than 10 years, tracer experiments have been performed in the Stripa mine as part of the Stripa project to investigate the properties of both 'average' fractured rock and fracture zones. Experiments have been performed that have ranged from a few decimeters, to examine the diffusion into the rock matrix, up to tracer migration to a drift more than 50 meters from the injection point. This report compiles the results and experience that have been gained from all these tracer experiments. The experiments that are described in this report are: * The in-situ diffusion experiment where simultaneous flow and diffusion of tracers in undisturbed rock were studied over more than 3 years to validate diffusivities obtained under laboratory conditions. * Migration in a single fracture where water flow distribution and tracer transport were studied using both conservative and sorbing tracers over migration distances up to 10 meters. * The 3-D migration experiment where water inflow and tracer transport to a drift covered with 350 plastic sheet were investigated to get information on flow porosity, dispersion and channeling. The transport distances were between 10 and 56 meters from the injection points to the drift. * The channeling experiments in which the aim was to examine the channeling properties of single fractures in detail. Pressure pulse tests and tracer experiments were performed over a distances of 2 meters. * The tracer migration experiment in the validation drift where the tracer were injected mainly in a fracture zone and the collection was inside both a drift covered with plastic sheets similar to in the 3-D experiment as well as in a borehole. The distances between injection and sampling location were between 10 and 25 meters. (57 refs.) (au)

  7. Japanese Migration and the Americas: An Introduction to the Study of Migration.

    Science.gov (United States)

    Mukai, Gary; Brunette, Rachel

    This curriculum module introduces students to the study of migration, including a brief overview of some categories of migration and reasons why people migrate. As a case study, the module uses the Japanese migration experience in the United States, Peru, Brazil, Canada, Mexico, Argentina, Bolivia, and Paraguay. The module introduces students to…

  8. Optimization of the fuel cycle

    International Nuclear Information System (INIS)

    Kidd, S.W.; Balu, K.; Boczar, P.G.; Krebs, W.D.

    1999-01-01

    The nuclear fuel cycle can be optimized subject to a wide range of criteria. Prime amongst these are economics, sustainability of resources, environmental aspects, and proliferation-resistance of the fuel cycle. Other specific national objectives will also be important. These criteria, and their relative importance, will vary from country to country, and with time. There is no single fuel cycle strategy that is optimal for all countries. Within the short term, the industry is attached to dominant thermal reactor technologies, which themselves have two main variants, a cycle closed by reprocessing of spent fuel and subsequent recycling and a once through one where spent fuel is stored in advance of geological disposal. However, even with current technologies, much can be done to optimize the fuel cycles to meet the relevant criteria. In the long term, resource sustainability can be assured for centuries through the use of fast breeder reactors, supporting high-conversion thermal reactors, possibly also utilizing the thorium cycle. These must, however, meet the other key criteria by being both economic and safe. (author)

  9. Nuclide-migration field experiments

    International Nuclear Information System (INIS)

    Erdal, B.R.; Wolfsberg, K.; Johnstone, J.K.; Erickson, K.L.; Friedman, A.M.; Fried, S.; Hines, J.J.

    1981-03-01

    When considering groundwater flow and radionuclide retention in the complex flow systems that can occur in geologic formations, one has a serious problem in determining if laboratory studies are being performed under conditions appropriate to natural systems. This document is the project plan for a program designed to begin to address these problems. The project is being carried out jointly by the Los Alamos National Laboratory, Sandia National Laboratories, and Argonne National Laboratory. The work has three principal objectives: (1) to develop the experimental, instrumental, and safety techniques necessary to conduct controlled, small-scale radionuclide migration field experiments, including those involving actinides; (2) to use these techniques to define radionuclide migration through rock by performing generic, at-depth experiments under closely monitored conditions; and (3) to determine whether available lithologic, geochemical, and hydrologic properties together with existing or developing transport models are sufficient and appropriate to describe real field conditions

  10. MIGRATION OF ORACLE HR DATABASE

    CERN Multimedia

    ais.support@cern.ch

    2001-01-01

    Restricted services from 3 to 7 November 2001 Due to the migration of the Oracle HR application to the Web, some services which rely on the application's availability may be disturbed from Friday 2 November at 17:30 until Thursday 8 November at 08:30. Amongst those services: HR Division: records office, recruitment, claims and benefits. FI Division: personnel accounting, advances and claims. ST Division: registration office (access cards). SPL Division: external firm staff records. EP Division: users' office. Experiments' secretariats: PIE, Greybook. Divisional secretariats: externals, internal addresses. All information concerning this migration is available at: http://ais.cern.ch We apologize for any inconvenience and thank you in advance for your understanding.

  11. Nuclide-migration field experiments

    Energy Technology Data Exchange (ETDEWEB)

    Erdal, B.R.; Wolfsberg, K.; Johnstone, J.K.; Erickson, K.L.; Friedman, A.M.; Fried, S.; Hines, J.J.

    1981-03-01

    When considering groundwater flow and radionuclide retention in the complex flow systems that can occur in geologic formations, one has a serious problem in determining if laboratory studies are being performed under conditions appropriate to natural systems. This document is the project plan for a program designed to begin to address these problems. The project is being carried out jointly by the Los Alamos National Laboratory, Sandia National Laboratories, and Argonne National Laboratory. The work has three principal objectives: (1) to develop the experimental, instrumental, and safety techniques necessary to conduct controlled, small-scale radionuclide migration field experiments, including those involving actinides; (2) to use these techniques to define radionuclide migration through rock by performing generic, at-depth experiments under closely monitored conditions; and (3) to determine whether available lithologic, geochemical, and hydrologic properties together with existing or developing transport models are sufficient and appropriate to describe real field conditions.

  12. Physicists' Forced Migrations under Hitler

    Science.gov (United States)

    Beyerchen, Alan

    2011-03-01

    When the Nazis came to power in early 1933 they initiated formal and informal measures that forced Jews and political opponents from public institutions such as universities. Some physicists retired and others went into industry, but most emigrated. International communication and contact made emigration a viable option despite the desperate economic times in the Great Depression. Another wave of emigrations followed the annexation of Austria in 1938. Individual cases as well as general patterns of migration and adaptation to new environments will be examined in this presentation. One important result of the forced migrations was that many of the physicists expelled under Hitler played important roles in strengthening physics elsewhere, often on the Allied side in World War II.

  13. Migration from India to Australia.

    Science.gov (United States)

    Awasthi, S P; Chandra, A

    1994-01-01

    "The article examines the contemporary trends and future prospects of migration from India to Australia. The focus is on Indian Settlers and Temporary Entrants admitted to Australia for employment and Indian students admitted to Australia for higher studies. The volume of emigration for permanent residence during the early 1990s has made India one of the leading source countries of migration to Australia. A majority of Indians admitted as Settlers every year join the labor force. Recent data indicate that, among Indian Settlers, there is a preponderance of unsponsored Independent Skilled Migrants. Given the anticipated growth in the number of Indian students, the coming years are likely to witness a spurt in Skilled Temporary Workers from India." excerpt

  14. Migration towards Windows 2000/XP

    International Nuclear Information System (INIS)

    Gal, J.

    2004-01-01

    The article deals with interesting technical solutions used in the project 'Migration towards Windows 2000/XP', which was introduced by the company AITEN, Plc for companies SE Plc, SEPS Plc and TEKO, Plc in the period 2002 and 2003. The contents of the project was migration of about 100 servers and more than 4 000 PC to the Windows 2000 and XP environs. The result of the project is a unified and documented system in the field of file, print and small application servers and PC. It has enabled to increase the system reliability and availability, to decrease the total costs for administration and operation and to establish the steady environs for users of the applications. (author)

  15. Fisetin regulates astrocyte migration and proliferation in vitro.

    Science.gov (United States)

    Wang, Nan; Yao, Fang; Li, Ke; Zhang, Lanlan; Yin, Guo; Du, Mingjun; Wu, Bingyi

    2017-04-01

    Fisetin (3,3',4',7-tetrahydroxyflavone) is a plant flavonol found in fruits and vegetables that has been reported to inhibit migration and proliferation in several types of cancer. Reactive astrogliosis involves astrocyte migration and proliferation, and contributes to the formation of glial scars in central nervous system (CNS) disorders. However, the effect of fisetin on the migration and proliferation of astrocytes remains unclear. In this study, we found that fisetin inhibited astrocyte migration in a scratch-wound assay and diminished the phosphorylation of focal adhesion kinase (FAK; Tyr576/577 and paxillin (Tyr118). It also suppressed cell proliferation, as indicated by the decreased number of 5-ethynyl-2'-deoxyuridine (EdU)-positive cells, induced cell cycle arrest in the G1 phase, reduced the percentage of cells in the G2 and S phase (as measured by flow cytometry), and decreased cyclin D1 expression, but had no effect on apoptosis. Fisetin also decreased the phosphorylation levels of Akt and extracellular signal-regulated kinase (Erk)1/2, but had no effect on the phosphorylation of p38 mitogen-activated protein kinase (MAPK). These results indicate that fisetin inhibits aggressive cell phenotypes by suppressing cell migration and proliferation via the Akt/Erk signaling pathway. Fisetin may thus have potential for use as a therapeutic strategy targeting reactive astrocytes, which may lead to the inhibition of glial scar formation in vitro.

  16. Solar-cycle variation of zonal and meridional flow

    International Nuclear Information System (INIS)

    Komm, R; Howe, R; Hill, F; Hernandez, I Gonzalez; Haber, D

    2011-01-01

    We study the variation with the solar cycle of the zonal and meridional flows in the near-surface layers of the solar convection zone. We have analyzed MDI Dynamics-Program data with ring-diagram analysis covering the rising phase of cycle 23, while the analyzed GONG high-resolution data cover the maximum and declining phase of cycle 23. For the zonal flow, the migration with latitude of the flow pattern is apparent in the deeper layers, while for the meridional flow, a migration with latitude is apparent only in the layers close to the surface. The faster-than-average bands of the zonal flow associated with the new cycle are clearly visible. Similarly, a pattern related to the new cycle appears in the residual meridional flow. We also study the flow differences between the hemispheres during the course of the solar cycle. The difference pattern of the meridional flow is slanted in latitude straddling the faster-than-average band of the torsional oscillation pattern in the zonal flow. The difference pattern of the zonal flow, on the other hand, resembles the cycle variation of the meridional flow. In addition, the meridional flow during the minimum of cycle 23/24 appears to be slightly stronger than during the previous minimum of cycle 22/23.

  17. Studies of a Combined-Cycle Engine

    OpenAIRE

    苅田, 丈士; KANDA, Takeshi

    2003-01-01

    For a Single-Stage-to-Orbit (SSTO) aerospace plane (Fig.1), several engines will be necessary to reach orbit. The combined-cycle engine incorporates several operational modes in a single engine. Study of the combined cycle engine has a long history, and several kinds of such engines have been proposed and studied. When several engines are mounted on a vehicle, each engine of the system will show a performance higher than that of the combined cycle engine. However, during the operation of one ...

  18. ILLEGAL MIGRATION-CONCEPTUAL DELIMITATIONS

    Directory of Open Access Journals (Sweden)

    CRISTINA FLORINA POPESCU (PANAIT

    2013-05-01

    Full Text Available Illegal migration is a mobile phenomenon, which ignores national borders, a threat that originates outside the community and extends to Western societies. This phenomenon is becoming larger and irregular migrants are often in a precarious situation and exposed to the criminals involved in various manifestations of organized crime. The future risk factors of the illegal migration are the demographic bomb, because the population is decreasing in European countries and increasing rapidly in poorer countries, droughts, floods, deforestation, that cause conflicts between climate refugees , extreme poverty, totalitarian regimes, epidemics, can trigger millions of people, the elderly and the working population imbalance which leads to the permanent import of immigrants To combat this phenomenon, states must engage and cooperate with each other. Measures taken by states must balance their integration policy for immigrants, legally residents and asylum policy to comply with international conventions. Also, states must adopt anti-immigrant policies, consisting of subordination visa policy to the interests of international security and exchange of information and, not least, to continue the Schengen process, as a value of humanitarian law applied in the field. The aim of the research is to characterize this dangerous phenomenon for the society and the goal is to identify strategies to combat illegal migration.

  19. Seasonal associations with urban light pollution for nocturnally migrating bird populations.

    Science.gov (United States)

    La Sorte, Frank A; Fink, Daniel; Buler, Jeffrey J; Farnsworth, Andrew; Cabrera-Cruz, Sergio A

    2017-11-01

    The spatial extent and intensity of artificial light at night (ALAN) has increased worldwide through the growth of urban environments. There is evidence that nocturnally migrating birds are attracted to ALAN, and there is evidence that nocturnally migrating bird populations are more likely to occur in urban areas during migration, especially in the autumn. Here, we test if urban sources of ALAN are responsible, at least in part, for these observed urban associations. We use weekly estimates of diurnal occurrence and relative abundance for 40 nocturnally migrating bird species that breed in forested environments in North America to assess how associations with distance to urban areas and ALAN are defined across the annual cycle. Migratory bird populations presented stronger than expected associations with shorter distances to urban areas during migration, and stronger than expected association with higher levels of ALAN outside and especially within urban areas during migration. These patterns were more pronounced during autumn migration, especially within urban areas. Outside of the two migration periods, migratory bird populations presented stronger than expected associations with longer distances to urban areas, especially during the nonbreeding season, and weaker than expected associations with the highest levels of ALAN outside and especially within urban areas. These findings suggest that ALAN is associated with higher levels of diurnal abundance along the boundaries and within the interior of urban areas during migration, especially in the autumn when juveniles are undertaking their first migration journey. These findings support the conclusion that urban sources of ALAN can broadly effect migratory behavior, emphasizing the need to better understand the implications of ALAN for migratory bird populations. © 2017 John Wiley & Sons Ltd.

  20. The centriole duplication cycle

    Science.gov (United States)

    Fırat-Karalar, Elif Nur; Stearns, Tim

    2014-01-01

    Centrosomes are the main microtubule-organizing centre of animal cells and are important for many critical cellular and developmental processes from cell polarization to cell division. At the core of the centrosome are centrioles, which recruit pericentriolar material to form the centrosome and act as basal bodies to nucleate formation of cilia and flagella. Defects in centriole structure, function and number are associated with a variety of human diseases, including cancer, brain diseases and ciliopathies. In this review, we discuss recent advances in our understanding of how new centrioles are assembled and how centriole number is controlled. We propose a general model for centriole duplication control in which cooperative binding of duplication factors defines a centriole ‘origin of duplication’ that initiates duplication, and passage through mitosis effects changes that license the centriole for a new round of duplication in the next cell cycle. We also focus on variations on the general theme in which many centrioles are created in a single cell cycle, including the specialized structures associated with these variations, the deuterosome in animal cells and the blepharoplast in lower plant cells. PMID:25047614

  1. Changing global carbon cycle

    International Nuclear Information System (INIS)

    Canadell, Pep

    2007-01-01

    Full text: The increase in atmospheric carbon dioxide (C02) is the single largest human perturbation on the earth's radiative balance contributing to climate change. Its rate of change reflects the balance between anthropogenic carbon emissions and the dynamics of a number of terrestrial and ocean processes that remove or emit C02. It is the long term evolution of this balance that will determine to large extent the speed and magnitude of the human induced climate change and the mitigation requirements to stabilise atmospheric C02 concentrations at any given level. In this talk, we show new trends in global carbon sources and sinks, with particularly focus on major shifts occurring since 2000 when the growth rate of atmospheric C02 has reached its highest level on record. The acceleration in the C02 growth results from the combination of several changes in properties of the carbon cycle, including: acceleration of anthropogenic carbon emissions; increased carbon intensity of the global economy, and decreased efficiency of natural carbon sinks. We discuss in more detail some of the possible causes of the reduced efficiency of natural carbon sinks on land and oceans, such as the decreased net sink in the Southern Ocean and on terrestrial mid-latitudes due to world-wide occurrence of drought. All these changes reported here characterise a carbon cycle that is generating stronger than expected climate forcing, and sooner than expected

  2. Bipolar mood cycles and lunar tidal cycles.

    Science.gov (United States)

    Wehr, T A

    2018-04-01

    In 17 patients with rapid cycling bipolar disorder, time-series analyses detected synchronies between mood cycles and three lunar cycles that modulate the amplitude of the moon's semi-diurnal gravimetric tides: the 14.8-day spring-neap cycle, the 13.7-day declination cycle and the 206-day cycle of perigee-syzygies ('supermoons'). The analyses also revealed shifts among 1:2, 1:3, 2:3 and other modes of coupling of mood cycles to the two bi-weekly lunar cycles. These shifts appear to be responses to the conflicting demands of the mood cycles' being entrained simultaneously to two different bi-weekly lunar cycles with slightly different periods. Measurements of circadian rhythms in body temperature suggest a biological mechanism through which transits of one of the moon's semi-diurnal gravimetric tides might have driven the patients' bipolar cycles, by periodically entraining the circadian pacemaker to its 24.84-h rhythm and altering the pacemaker's phase-relationship to sleep in a manner that is known to cause switches from depression to mania.

  3. National and international graduate migration flows.

    Science.gov (United States)

    Mosca, Irene; Wright, Robert E

    2010-01-01

    This article examines the nature of national and international graduate migration flows in the UK. Migration equations are estimated with microdata from a matched dataset of Students and Destinations of Leavers from Higher Education, information collected by the Higher Education Statistical Agency. The probability of migrating is related to a set of observable characteristics using multinomial logit regression. The analysis suggests that migration is a selective process with graduates with certain characteristics having considerably higher probabilities of migrating, both to other regions of the UK and abroad.

  4. Family migration and relative earnings potentials

    DEFF Research Database (Denmark)

    Foged, Mette

    2016-01-01

    of husband centered migration. Couples are more likely to migrate if household earnings potential is disproportionally due to one partner, and families react equally strongly to a male and a female relative advantage in educational earnings potential. These results are driven by households with a strong......A unitarian model of family migration in which families may discount wives’ private gains is used to derive testable predictions regarding the type of couples that select into migrating. The empirical tests show that gender neutral family migration cannot be rejected against the alternative...

  5. Avian migrants adjust migration in response to environmental conditions en route

    DEFF Research Database (Denmark)

    Tøttrup, Anders P; Thorup, Kasper; Rainio, Kalle

    2008-01-01

    The onset of migration in birds is assumed to be primarily under endogenous control in long-distance migrants. Recently, climate changes appear to have been driving a rapid change in breeding area arrival. However, little is known about the climatic factors affecting migratory birds during...... covering the entire migration period every year from observatories located in the Middle East and northern Europe, we show that passage of the Sahara Desert is delayed and correlated with improved conditions in the wintering areas. By contrast, migrants travel more rapidly through Europe, and adjust...... the migration cycle, or whether recently reported phenological changes are caused by plastic behavioural responses or evolutionary change. Here, we investigate how environmental conditions in the wintering areas as well as en route towards breeding areas affect timing of migration. Using data from 1984 to 2004...

  6. Family characteristics of internal migration in China.

    Science.gov (United States)

    Rowland, D T

    1992-03-01

    Data from the 1986 survey of migration conducted by the Chinese Academy of Social Sciences (CASS) were used to examine family characteristics of internal migrants to urban areas in China. The influence of the family either directly or indirectly is considered as part of life cycle events. .2% of households in 74 cities and towns were surveyed (100,267 persons). Data were analyzed 1) for persons who moved within 10 years of the survey (47%--17,890 out of 38,104 in-migrants), and 2) by last move by age regardless of when (72% between 1966-86). The literature and conditions in China strongly support that family welfare is likely to be a significant underlying influence on patterns and selectivity of migration in China. The CASS survey reveals that the most movers were from nuclear families aged 25-44 years, followed by stem families (a couple plus 1 or more parents). 6 factors are identified for sustaining co-residence within generations. Migrations during 1977-86 showed that 41% of males aged 20-24 years had moved at least once (18% were married), while for females the figure was 25% (50% were married). 56% of males moving at ages 25-29 years were married, and 90% of migrant males aged 30-34 years were married. 78% of married females aged 25-29 years and 94% of those aged 30-34 years moved. 23% of widowed females aged 50-54 years were in-migrants, and 69% were aged 65 years and widowed. The opportunity for 2- and 3- generation households is expected t decline over the next 50 years as the population ages and becomes larger than the supporting population. 44% of young-old women (75-74 years) with no children and 25-33% of young-old women total had moved within the last 10 years. 43% of women aged 75 years or older with 5 or more children moved within 10 years, while only 24% with no children had. Women aged 35-54 years had low rates of movement with high parity, while those aged 25-44 with 1 or no children had higher rates of movement. Parity is increasingly

  7. How birds weather the weather: avian migration in the mid-latitudes

    NARCIS (Netherlands)

    Kemp, M.U.

    2012-01-01

    The life cycle of many bird species involves the twice-annual movement between a breeding ground and a wintering ground that we refer to as `migration'. To complete these journeys, birds must successfully navigate many obstacles including a dynamic atmosphere. To make optimal use of this

  8. Notch1-Dll4 signaling and mechanical force regulate leader cell formation during collective cell migration

    OpenAIRE

    Riahi, Reza; Sun, Jian; Wang, Shue; Long, Min; Zhang, Donna D.; Wong, Pak Kin

    2015-01-01

    At the onset of collective cell migration, a subset of cells within an initially homogenous population acquires a distinct “leader” phenotype with characteristic morphology and motility. However, the factors driving leader cell formation as well as the mechanisms regulating leader cell density during the migration process remain to be determined. Here, we use single cell gene expression analysis and computational modeling to show that leader cell identity is dynamically regulated by Dll4 sign...

  9. Modeling seasonal migration of fall armyworm moths

    Science.gov (United States)

    Westbrook, J. K.; Nagoshi, R. N.; Meagher, R. L.; Fleischer, S. J.; Jairam, S.

    2016-02-01

    Fall armyworm, Spodoptera frugiperda (J.E. Smith), is a highly mobile insect pest of a wide range of host crops. However, this pest of tropical origin cannot survive extended periods of freezing temperature but must migrate northward each spring if it is to re-infest cropping areas in temperate regions. The northward limit of the winter-breeding region for North America extends to southern regions of Texas and Florida, but infestations are regularly reported as far north as Québec and Ontario provinces in Canada by the end of summer. Recent genetic analyses have characterized migratory pathways from these winter-breeding regions, but knowledge is lacking on the atmosphere's role in influencing the timing, distance, and direction of migratory flights. The Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT) model was used to simulate migratory flight of fall armyworm moths from distinct winter-breeding source areas. Model simulations identified regions of dominant immigration from the Florida and Texas source areas and overlapping immigrant populations in the Alabama-Georgia and Pennsylvania-Mid-Atlantic regions. This simulated migratory pattern corroborates a previous migratory map based on the distribution of fall armyworm haplotype profiles. We found a significant regression between the simulated first week of moth immigration and first week of moth capture (for locations which captured ≥10 moths), which on average indicated that the model simulated first immigration 2 weeks before first captures in pheromone traps. The results contribute to knowledge of fall armyworm population ecology on a continental scale and will aid in the prediction and interpretation of inter-annual variability of insect migration patterns including those in response to climatic change and adoption rates of transgenic cultivars.

  10. Lipid raft association restricts CD44-ezrin interaction and promotion of breast cancer cell migration.

    LENUS (Irish Health Repository)

    Donatello, Simona

    2012-12-01

    Cancer cell migration is an early event in metastasis, the main cause of breast cancer-related deaths. Cholesterol-enriched membrane domains called lipid rafts influence the function of many molecules, including the raft-associated protein CD44. We describe a novel mechanism whereby rafts regulate interactions between CD44 and its binding partner ezrin in migrating breast cancer cells. Specifically, in nonmigrating cells, CD44 and ezrin localized to different membranous compartments: CD44 predominantly in rafts, and ezrin in nonraft compartments. After the induction of migration (either nonspecific or CD44-driven), CD44 affiliation with lipid rafts was decreased. This was accompanied by increased coprecipitation of CD44 and active (threonine-phosphorylated) ezrin-radixin-moesin (ERM) proteins in nonraft compartments and increased colocalization of CD44 with the nonraft protein, transferrin receptor. Pharmacological raft disruption using methyl-β-cyclodextrin also increased CD44-ezrin coprecipitation and colocalization, further suggesting that CD44 interacts with ezrin outside rafts during migration. Conversely, promoting CD44 retention inside lipid rafts by pharmacological inhibition of depalmitoylation virtually abolished CD44-ezrin interactions. However, transient single or double knockdown of flotillin-1 or caveolin-1 was not sufficient to increase cell migration over a short time course, suggesting complex crosstalk mechanisms. We propose a new model for CD44-dependent breast cancer cell migration, where CD44 must relocalize outside lipid rafts to drive cell migration. This could have implications for rafts as pharmacological targets to down-regulate cancer cell migration.

  11. Untangling cell tracks: Quantifying cell migration by time lapse image data analysis.

    Science.gov (United States)

    Svensson, Carl-Magnus; Medyukhina, Anna; Belyaev, Ivan; Al-Zaben, Naim; Figge, Marc Thilo

    2018-03-01

    Automated microscopy has given researchers access to great amounts of live cell imaging data from in vitro and in vivo experiments. Much focus has been put on extracting cell tracks from such data using a plethora of segmentation and tracking algorithms, but further analysis is normally required to draw biologically relevant conclusions. Such relevant conclusions may be whether the migration is directed or not, whether the population has homogeneous or heterogeneous migration patterns. This review focuses on the analysis of cell migration data that are extracted from time lapse images. We discuss a range of measures and models used to analyze cell tracks independent of the biological system or the way the tracks were obtained. For single-cell migration, we focus on measures and models giving examples of biological systems where they have been applied, for example, migration of bacteria, fibroblasts, and immune cells. For collective migration, we describe the model systems wound healing, neural crest migration, and Drosophila gastrulation and discuss methods for cell migration within these systems. We also discuss the role of the extracellular matrix and subsequent differences between track analysis in vitro and in vivo. Besides methods and measures, we are putting special focus on the need for openly available data and code, as well as a lack of common vocabulary in cell track analysis. © 2017 International Society for Advancement of Cytometry. © 2017 International Society for Advancement of Cytometry.

  12. European Integration, Labour Market Dynamics and Migration Flows

    Directory of Open Access Journals (Sweden)

    Martinoia, Michela

    2011-06-01

    Full Text Available The paper has two objectives. Firstly, we wish to evaluate whether a greater economic integration has effects, and of what type, on migration flows from Central and Eastern Europe (New Member States of the EU, NMS towards the fifteen countries of the European Union (EU-15. Secondly, we wish to understand what effect the migration flows from the NMS have on the labour market of the receiving countries in the EU-15. The most suitable theoretical context that seems to summarise European labour market characteristics is that of the insider/outsider model by Layard, Nickell and Jackman (Layard et al., 1991. We have modified the above mentioned model by introducing two innovations. Firstly, we constructed three measures that act as a proxy for economic integration: the Intra Regional Trade Index (IRTI, Global Trade Index (GTI and Financial Market Integration (FMI. Then we placed the three indicators into the insider/outsider model to arrive at a modified version of Layard, Nickell and Jackman (Layard et al., 1991. The second innovative contribution was the introduction of an equation modelling migration flows. The creation of this equation is inspired by the neo-classical approach to migration theory (Harris-Todaro, 1970. The theoretical model, based on rational expectations, has been solved to find the equilibrium solution and the impact multipliers. We then carried out an empirical analysis, which involved estimating a Structural Vector Autoregression Model (SVAR. The aim of this estimation was to evaluate, on the one hand, the effect that greater European integration (a positive shock to the integration indicators has on migration flows, and, on the other, to measure the type of effect that migration flows could have on the labour market of the EU-15 countries, considered as a single entity. The results of our empirical evidence show that economic integration does generate significant effects on migration flows from the enlargement countries

  13. An economic analysis of migration in Mexico.

    Science.gov (United States)

    Greenwood, M J; Ladman, J R

    1978-07-01

    This paper analyzes internal migration in Mexico over the 1960-70 period. A model of the determinants of migration is specified and estimated for aggregated interstate migration flows. Results show that distance serves as a significant deterrent to migration, that higher destination earning levels are attractive to migrants, and that regions with high unemployment rates experience lower rates of inmigration. An unanticipated finding is that regions with higher earning levels have greater rates of outmigration. The data are disaggregated to examine separate migration relationships for each state. The results are that distance is a lesser deterrent for those migrants with more accessible alternatives, that higher earning levels reduce the deterring effects of distance, and that regions with higher earning levels have lower associated elasticities of migration. It is concluded that economic factors have played a crucial role in internal migration and thus in the changing occupational and geographic structure of the Mexican labor force.

  14. The origin and migration of primordial germ cells in sturgeons.

    Directory of Open Access Journals (Sweden)

    Taiju Saito

    Full Text Available Primordial germ cells (PGCs arise elsewhere in the embryo and migrate into developing gonadal ridges during embryonic development. In several model animals, formation and migration patterns of PGCs have been studied, and it is known that these patterns vary. Sturgeons (genus Acipenser have great potential for comparative and evolutionary studies of development. Sturgeons belong to the super class Actinoptergii, and their developmental pattern is similar to that of amphibians, although their phylogenetic position is an out-group to teleost fishes. Here, we reveal an injection technique for sturgeon eggs allowing visualization of germplasm and PGCs. Using this technique, we demonstrate that the PGCs are generated at the vegetal pole of the egg and they migrate on the yolky cell mass toward the gonadal ridge. We also provide evidence showing that PGCs are specified by inheritance of maternally supplied germplasm. Furthermore, we demonstrate that the migratory mechanism is well-conserved between sturgeon and other remotely related teleosts, such as goldfish, by a single PGCs transplantation (SPT assay. The mode of PGCs specification in sturgeon is similar to that of anurans, but the migration pattern resembles that of teleosts.

  15. Essays on economic cycles

    NARCIS (Netherlands)

    Groot, de E.A. (Bert)

    2006-01-01

    Schumpeter’s line of thought of multiple economic cycles is further investigated. The existence of multiple cycles in economic variables is demonstrated. In basic innovations five different cycles are found. Multiple cycle structures are shown in various macro-economic variables from the United

  16. Migration Phenotype of Brain-Cancer Cells Predicts Patient Outcomes

    Directory of Open Access Journals (Sweden)

    Chris L. Smith

    2016-06-01

    Full Text Available Glioblastoma multiforme is a heterogeneous and infiltrative cancer with dismal prognosis. Studying the migratory behavior of tumor-derived cell populations can be informative, but it places a high premium on the precision of in vitro methods and the relevance of in vivo conditions. In particular, the analysis of 2D cell migration may not reflect invasion into 3D extracellular matrices in vivo. Here, we describe a method that allows time-resolved studies of primary cell migration with single-cell resolution on a fibrillar surface that closely mimics in vivo 3D migration. We used this platform to screen 14 patient-derived glioblastoma samples. We observed that the migratory phenotype of a subset of cells in response to platelet-derived growth factor was highly predictive of tumor location and recurrence in the clinic. Therefore, migratory phenotypic classifiers analyzed at the single-cell level in a patient-specific way can provide high diagnostic and prognostic value for invasive cancers.

  17. Return migration as failure or success? : The determinants of return migration intentions among Moroccan migrants in Europe

    NARCIS (Netherlands)

    de Haas, H.; Fokkema, T.; Fihri, M.F.

    2015-01-01

    Different migration theories generate competing hypotheses with regard to determinants of return migration. While neoclassical migration theory associates migration to the failure to integrate at the destination, the new economics of labour migration sees return migration as the logical stage after

  18. Philippine migration policy: dilemmas of a crisis.

    Science.gov (United States)

    Battistella, G

    1999-04-01

    Philippine migration policy is traced from the early 1970s to the present. The main migration trends in the 1990s are described. An assessment is made of the efficacy and appropriateness of present migration policy in light of the economic crisis. A regional approach to migration policy is necessary in order to encourage placing migration as a greater priority on national agendas and in bilateral agreements. In the Philippines, migrants are considered better paid workers, which diminishes their importance as a legislative or program priority. Santo Tomas (1998) conducted an empirical assessment of migration policies in the Philippines, but refinement is needed. Although migration is a transnational experience, there is little dialogue and cooperation among countries. Philippine migration policy defines its role as an information resource for migrants. Policy shifted from labor export to migrant management in the public and private sectors. Predeparture information program studies are recommending a multi-stage process that would involve all appropriate parties. There is talk of including migration information in the education curriculum. There are a variety of agendas, competing interests, and information resources between migration networks and officiating agencies. The Asian financial crisis may have a mild impact, but there are still issues of reintegration, protection, and employment conditions

  19. Asian student migration to Australia.

    Science.gov (United States)

    Shu, J; Hawthorne, L

    1996-01-01

    "This paper presents an overview of Asian student migration to Australia, together with an analysis of political and educational aspects of the overseas student programme. It focuses on some significant consequences of this flow for Australia. The characteristics of key student groups are contrasted to provide some perspective of the diversity of historical and cultural backgrounds, with the source countries of Malaysia, Indonesia and PRC [China] selected as case studies. Since the issue of PRC students in Australia has attracted considerable public attention and policy consideration, particular focus is placed on their experience." (SUMMARY IN FRE AND SPA) excerpt

  20. Clandestine labor migration to Taiwan.

    Science.gov (United States)

    Tsay, C

    1992-01-01

    "Illegal migration to Taiwan is a recent phenomenon but with a rapid rate of increase. Most illegal foreign workers enter on visitor's visas and overstay. This paper's detailed analysis of official data reveals that Malaysia, Philippines, Indonesia and Thailand are the major sources, providing a stock of mostly male workers numbering around 40,000. Sociodemographic and attitudinal changes among Taiwanese workers coupled with labor shortages in low-skilled jobs are pressuring the Taiwanese government to formulate plans for a systematic importation of foreign labor." excerpt

  1. Migrating Applications to IPv6

    CERN Document Server

    York, Dan

    2011-01-01

    If IPv6 is to be adopted on a large scale, the applications running on desktop systems, laptops, and even mobile devices need to work just as well with this protocol as they do with IPv4. This concise book takes you beyond the network layer and helps you explore the issues you need to address if you are to successfully migrate your apps to IPv6. It's ideal for application developers, system/network architects, product managers, and others involved in moving your network to IPv6. Explore changes you need to make in your application's user interfaceMake sure your application is retrieving corre

  2. Radionuclide migration in geological formations

    International Nuclear Information System (INIS)

    Barbreau, A.; Heremans, R.; Skytte Jensen, B.

    1980-01-01

    Radioactive waste disposal into geological formation is based on the capacity of rocks to confine radioactivity for a long period of time. Radionuclide migration from the repository to the environment depends on different mechanisms and phenomena whose two main ones are groundwater flow and the retention and ion-exchange property of rocks. Many studies are underway presently in EEC countries concerning hydrodynamic characteristics of deep geological formations as well as in radionuclide retention capacity and modelling. Important results have already been achieved which show the complexity of some phenomena and further studies shall principally be developed taking into account real conditions of the repository and its environment

  3. URG11 Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion

    Directory of Open Access Journals (Sweden)

    Bin Pan

    2018-01-01

    Full Text Available Upregulated gene 11 (URG11, a new gene upregulated by hepatitis B virus X protein, is involved in the development and progression of several tumors, including liver, stomach, lung, and colon cancers. However, the role of URG11 in prostate cancer remains yet to be elucidated. By determined expression in human prostate cancer tissues, URG11 was found significantly upregulated and positively correlated with the severity of prostate cancer, compared with that in benign prostatic hyperplasia tissues. Further, the mRNA and protein levels of URG11 were significantly upregulated in human prostate cancer cell lines (DU145, PC3, and LNCaP, compared with human prostate epithelial cell line (RWPE-1. Moreover, by the application of siRNA against URG11, the proliferation, migration, and invasion of prostate cancer cells were markedly inhibited. Genetic knockdown of URG11 also induced cell cycle arrest at G1/S phase, induced apoptosis, and decreased the expression level of β-catenin in prostate cancer cells. Overexpression of URG11 promoted the expression of β-catenin, the growth, the migration, and invasion ability of prostate cancer cells. Taken together, this study reveals that URG11 is critical for the proliferation, migration, and invasion in prostate cancer cells, providing the evidence of URG11 to be a novel potential therapeutic target of prostate cancer.

  4. Nuclear power fuel cycle

    International Nuclear Information System (INIS)

    Havelka, S.; Jakesova, L.

    1982-01-01

    Economic problems are discussed of the fuel cycle (cost of the individual parts of the fuel cycle and the share of the fuel cycle in the price of 1 kWh), the technological problems of the fuel cycle (uranium ore mining and processing, uranium isotope enrichment, the manufacture of fuel elements, the building of long-term storage sites for spent fuel, spent fuel reprocessing, liquid and gaseous waste processing), and the ecologic aspects of the fuel cycle. (H.S.)

  5. Metabolic Interaction between Urea Cycle and Citric Acid Cycle Shunt: A Guided Approach

    Science.gov (United States)

    Pesi, Rossana; Balestri, Francesco; Ipata, Piero L.

    2018-01-01

    This article is a guided pedagogical approach, devoted to postgraduate students specializing in biochemistry, aimed at presenting all single reactions and overall equations leading to the metabolic interaction between ureagenesis and citric acid cycle to be incorporated into a two-three lecture series about the interaction of urea cycle with other…

  6. Migration of cesium-137 through sandy soil layer effect of fine silt on migration

    International Nuclear Information System (INIS)

    Ohnuki, Toshihiko; Wadachi, Yoshiki

    1983-01-01

    The migration of 137 Cs through sandy soil layer was studied with consideration of the migration of fine silt by column method. It was found that a portion of fine silt migrated through the soil layer accompanying with 137 Cs. The mathematical migration model of 137 Cs involved the migration of fine silt through such soil layer was presented. This model gave a good accordance between calculated concentration distribution curve in sandy soil layer and effluent curve and observed those. So, this model seems to be advanced one for evaluating migration of 137 Cs in sandy soil layer with silt. (author)

  7. International migration patterns of Red-throated Loons (Gavia stellata) from four breeding populations in Alaska

    Science.gov (United States)

    McCloskey, Sarah E.; Uher-Koch, Brian D.; Schmutz, Joel A.; Fondell, Thomas F.

    2018-01-01

    Identifying post-breeding migration and wintering distributions of migratory birds is important for understanding factors that may drive population dynamics. Red-throated Loons (Gavia stellata) are widely distributed across Alaska and currently have varying population trends, including some populations with recent periods of decline. To investigate population differentiation and the location of migration pathways and wintering areas, which may inform population trend patterns, we used satellite transmitters (n = 32) to describe migration patterns of four geographically separate breeding populations of Red-throated Loons in Alaska. On average (± SD) Red-throated Loons underwent long (6,288 ± 1,825 km) fall and spring migrations predominantly along coastlines. The most northern population (Arctic Coastal Plain) migrated westward to East Asia and traveled approximately 2,000 km farther to wintering sites than the three more southerly populations (Seward Peninsula, Yukon-Kuskokwim Delta, and Copper River Delta) which migrated south along the Pacific coast of North America. These migration paths are consistent with the hypothesis that Red-throated Loons from the Arctic Coastal Plain are exposed to contaminants in East Asia. The three more southerly breeding populations demonstrated a chain migration pattern in which the more northerly breeding populations generally wintered in more northerly latitudes. Collectively, the migration paths observed in this study demonstrate that some geographically distinct breeding populations overlap in wintering distribution while others use highly different wintering areas. Red-throated Loon population trends in Alaska may therefore be driven by a wide range of effects throughout the annual cycle.

  8. Freely migrating defects in ion-irradiated Cu3Au

    International Nuclear Information System (INIS)

    Wei, L.C.; Lang, E.; Flynn, C.P.; Averback, R.S.

    1999-01-01

    The efficiency of producing freely migrating vacancy defects in irradiated Cu 3 Au was examined using electrical resistivity measurements of radiation-induced ordering on highly perfect single-crystal films. Relative efficiencies for He, Ne, and Ar bombardments at different ion energy and specimen temperature were obtained. The ratio of the efficiencies of 0.6 MeV Ne to He increased with temperature from ∼0.25 at 340 K to a saturation value of ∼0.40 at 520 K. For Ar and He, the ratio increased from ∼0.11 at 360 K to ∼0.18 at 540 K. Estimates indicate that about half of all defects created in cascades are freely migrating. copyright 1999 American Institute of Physics

  9. THE IMPACT OF MIGRATION ON ROMANIA'S ECONOMICAL AND SOCIAL DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    DIANA-MIHAELA POCIOVĂLIȘTEANU

    2014-02-01

    Full Text Available Free movement for people is one of the most fundamental freedoms guaranteed by European Union law and it is a necessary precondition for building a single market. Greater adaptability on the part of workers through migration process is also a key element in making Europe Union more competitive at a global level, and at an individual level enabling employees to raise their skills levels and their employability, income and career prospects. In this paper I’m trying to review several aspects regarding the Romanian labour market, the causes that determined the labour force to emigrate in European Union’s member states, as well as migrations’ effects on the supply and demand on the labour market. Migration can have both positive and negative effects on economical and social life from the origin country.

  10. Microfluidic gradient device for studying mesothelial cell migration and the effect of chronic carbon nanotube exposure

    International Nuclear Information System (INIS)

    Zhang, Hanyuan; Sun, Jianbo; Li, Xiang; Liu, Yuxin; Lohcharoenkal, Warangkana; Rojanasakul, Yon; Wang, Liying; Wu, Nianqiang

    2015-01-01

    Cell migration is one of the crucial steps in many physiological and pathological processes, including cancer development. Our recent studies have shown that carbon nanotubes (CNTs), similarly to asbestos, can induce accelerated cell growth and invasiveness that contribute to their mesothelioma pathogenicity. Malignant mesothelioma is a very aggressive tumor that develops from cells of the mesothelium, and is most commonly caused by exposure to asbestos. CNTs have a similar structure and mode of exposure to asbestos. This has raised a concern regarding the potential carcinogenicity of CNTs, especially in the pleural area which is a key target for asbestos-related diseases. In this paper, a static microfluidic gradient device was applied to study the migration of human pleural mesothelial cells which had been through a long-term exposure (4 months) to subcytotoxic concentration (0.02 µg cm −2 ) of single-walled CNTs (SWCNTs). Multiple migration signatures of these cells were investigated using the microfluidic gradient device for the first time. During the migration study, we observed that cell morphologies changed from flattened shapes to spindle shapes prior to their migration after their sensing of the chemical gradient. The migration of chronically SWCNT-exposed mesothelial cells was evaluated under different fetal bovine serum (FBS) concentration gradients, and the migration speeds and number of migrating cells were extracted and compared. The results showed that chronically SWCNT-exposed mesothelial cells are more sensitive to the gradient compared to non-SWCNT-exposed cells. The method described here allows simultaneous detection of cell morphology and migration under chemical gradient conditions, and also allows for real-time monitoring of cell motility that resembles in vivo cell migration. This platform would be much needed for supporting the development of more physiologically relevant cell models for better assessment and characterization of the

  11. Microfluidic gradient device for studying mesothelial cell migration and the effect of chronic carbon nanotube exposure

    Science.gov (United States)

    Zhang, Hanyuan; Lohcharoenkal, Warangkana; Sun, Jianbo; Li, Xiang; Wang, Liying; Wu, Nianqiang; Rojanasakul, Yon; Liu, Yuxin

    2015-07-01

    Cell migration is one of the crucial steps in many physiological and pathological processes, including cancer development. Our recent studies have shown that carbon nanotubes (CNTs), similarly to asbestos, can induce accelerated cell growth and invasiveness that contribute to their mesothelioma pathogenicity. Malignant mesothelioma is a very aggressive tumor that develops from cells of the mesothelium, and is most commonly caused by exposure to asbestos. CNTs have a similar structure and mode of exposure to asbestos. This has raised a concern regarding the potential carcinogenicity of CNTs, especially in the pleural area which is a key target for asbestos-related diseases. In this paper, a static microfluidic gradient device was applied to study the migration of human pleural mesothelial cells which had been through a long-term exposure (4 months) to subcytotoxic concentration (0.02 µg cm-2) of single-walled CNTs (SWCNTs). Multiple migration signatures of these cells were investigated using the microfluidic gradient device for the first time. During the migration study, we observed that cell morphologies changed from flattened shapes to spindle shapes prior to their migration after their sensing of the chemical gradient. The migration of chronically SWCNT-exposed mesothelial cells was evaluated under different fetal bovine serum (FBS) concentration gradients, and the migration speeds and number of migrating cells were extracted and compared. The results showed that chronically SWCNT-exposed mesothelial cells are more sensitive to the gradient compared to non-SWCNT-exposed cells. The method described here allows simultaneous detection of cell morphology and migration under chemical gradient conditions, and also allows for real-time monitoring of cell motility that resembles in vivo cell migration. This platform would be much needed for supporting the development of more physiologically relevant cell models for better assessment and characterization of the

  12. Upstream migration of Pacific lampreys in the John Day River, Oregon: Behavior, timing, and habitat use

    Science.gov (United States)

    Robinson, T. Craig; Bayer, J.M.

    2005-01-01

    Adult Pacific lamprey migration and habitat preferences for over-winter holding and spawning, and larval rearing in tributaries to the Columbia River are not well understood. The John Day River is one such tributary where larval and adult stages of this species have been documented, and its free-flowing character provided the opportunity to study migration of Pacific lampreys unimpeded by passage constraints. Forty-two adult Pacific lampreys were captured in the John Day River near its mouth during their upstream migration. Pacific lampreys were surgically implanted with radio transmitters and released onsite, and tracked by fixed-site, aerial, and terrestrial telemetry methods for nearly one year. Adults moved upstream exclusively at night, with a mean rate of 11.1 ?? 6.3 km/day. They halted upstream migration by September, and held a single position for approximately six months in the lateral margins of riffles and glides, using boulders for cover. More than half of Pacific lampreys resumed migration in March before ending movement in early May. Pacific lampreys that resumed migration in spring completed a median of 87% of their upstream migration before over-winter holding. Upon completing migration. Pacific lampreys briefly held position before beginning downstream movement at the end of May. Though not directly observed, halting migration and movement downstream were likely the result of spawning and death. Gains in adult Pacific lamprey passage through the Columbia River hydrosystem and tributaries may be made by improvements that would expedite migration during spring and summer and increase the quantity and variety of cover and refuge opportunities. ?? 2005 by the Northwest Scientific Association. All rights reserved.

  13. Antioxidant migration resistance of SiOx layer in SiOx/PLA coated film.

    Science.gov (United States)

    Huang, Chongxing; Zhao, Yuan; Su, Hongxia; Bei, Ronghua

    2018-02-01

    As novel materials for food contact packaging, inorganic silicon oxide (SiO x ) films are high barrier property materials that have been developed rapidly and have attracted the attention of many manufacturers. For the safe use of SiO x films for food packaging it is vital to study the interaction between SiO x layers and food contaminants, as well as the function of a SiO x barrier layer in antioxidant migration resistance. In this study, we deposited a SiO x layer on polylactic acid (PLA)-based films to prepare SiO x /PLA coated films by plasma-enhanced chemical vapour deposition. Additionally, we compared PLA-based films and SiO x /PLA coated films in terms of the migration of different antioxidants (e.g. t-butylhydroquinone [TBHQ], butylated hydroxyanisole [BHA], and butylated hydroxytoluene [BHT]) via specific migration experiments and then investigated the effects of a SiO x layer on antioxidant migration under different conditions. The results indicate that antioxidant migration from SiO x /PLA coated films is similar to that for PLA-based films: with increase of temperature, decrease of food simulant polarity, and increase of single-sided contact time, the antioxidant migration rate and amount in SiO x /PLA coated films increase. The SiO x barrier layer significantly reduced the amount of migration of antioxidants with small and similar molecular weights and similar physical and chemical properties, while the degree of migration blocking was not significantly different among the studied antioxidants. However, the migration was affected by temperature and food simulant. Depending on the food simulants considered, the migration amount in SiO x /PLA coated films was reduced compared with that in PLA-based films by 42-46%, 44-47%, and 44-46% for TBHQ, BHA, and BHT, respectively.

  14. Colloid migration in porous media

    International Nuclear Information System (INIS)

    Hunt, J.R.; McDowell-Boyer; Sitar, N.

    1985-01-01

    Retention of radionuclides for long periods near waste repositories depends upon multiple barriers, one of which is adsorption to immobile solid surfaces. Since small particles and colloidal matter have high adsorption capacities per unit mass and can be mobile in subsurface flows, colloidal transport of waste components requires analysis. Theories for predicting colloid migration through porous media have been developed in the filtration literature. The applicability of filtration theories for predicting particle and colloid transport. Emphasis is on suspended matter much smaller than pore sizes, where physical and chemical forces control migration rather than size dependent physical straining. In general, experimentally verifiable theories exist for particle filtration by clean media, and a sensitivity analysis is possible on particle and media properties and fluid flow rate. When particle aggregates accumulate within pores, media permeability decreases, resulting in flow field alteration and possible radionuclide isolation. An analysis of the limited experimental data available indicates that present theories cannot predict long-term colloid transport when permeability reduction occurs. The coupling of colloid attachment processes and the hydrologic flow processes requires more extensive laboratory field research than has currently been carried out. An emphasis on the fundamental mechanisms is necessary to enhance long-term predictability

  15. Signatures of natural selection between life cycle stages separated by metamorphosis in European eel.

    Science.gov (United States)

    Pujolar, J M; Jacobsen, M W; Bekkevold, D; Lobón-Cervià, J; Jónsson, B; Bernatchez, L; Hansen, M M

    2015-08-13

    Species showing complex life cycles provide excellent opportunities to study the genetic associations between life cycle stages, as selective pressures may differ before and after metamorphosis. The European eel presents a complex life cycle with two metamorphoses, a first metamorphosis from larvae into glass eels (juvenile stage) and a second metamorphosis into silver eels (adult stage). We tested the hypothesis that different genes and gene pathways will be under selection at different life stages when comparing the genetic associations between glass eels and silver eels. We used two sets of markers to test for selection: first, we genotyped individuals using a panel of 80 coding-gene single nucleotide polymorphisms (SNPs) developed in American eel; second, we investigated selection at the genome level using a total of 153,423 RAD-sequencing generated SNPs widely distributed across the genome. Using the RAD approach, outlier tests identified a total of 2413 (1.57%) potentially selected SNPs. Functional annotation analysis identified signal transduction pathways as the most over-represented group of genes, including MAPK/Erk signalling, calcium signalling and GnRH (gonadotropin-releasing hormone) signalling. Many of the over-represented pathways were related to growth, while others could result from the different conditions that eels inhabit during their life cycle. The observation of different genes and gene pathways under selection when comparing glass eels vs. silver eels supports the adaptive decoupling hypothesis for the benefits of metamorphosis. Partitioning the life cycle into discrete morphological phases may be overall beneficial since it allows the different life stages to respond independently to their unique selection pressures. This might translate into a more effective use of food and niche resources and/or performance of phase-specific tasks (e.g. feeding in the case of glass eels, migrating and reproducing in the case of silver eels).

  16. Modelling collective cell migration of neural crest.

    Science.gov (United States)

    Szabó, András; Mayor, Roberto

    2016-10-01

    Collective cell migration has emerged in the recent decade as an important phenomenon in cell and developmental biology and can be defined as the coordinated and cooperative movement of groups of cells. Most studies concentrate on tightly connected epithelial tissues, even though collective migration does not require a constant physical contact. Movement of mesenchymal cells is more independent, making their emergent collective behaviour less intuitive and therefore lending importance to computational modelling. Here we focus on such modelling efforts that aim to understand the collective migration of neural crest cells, a mesenchymal embryonic population that migrates large distances as a group during early vertebrate development. By comparing different models of neural crest migration, we emphasize the similarity and complementary nature of these approaches and suggest a future direction for the field. The principles derived from neural crest modelling could aid understanding the collective migration of other mesenchymal cell types. Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. Theories of international labor migration: an overview.

    Science.gov (United States)

    Stahl, C W

    1995-01-01

    "Emigration pressures are primarily the result of increasing inequalities between countries which, in turn, are the result of factors internal to less developed countries and their relations with developed countries. Both micro (neoclassical) and macrostructural theories of migration are reviewed. It is argued that the neoclassical theory of migration is often unjustly criticized and is sufficiently robust to incorporate those structural considerations which are at the core of macrostructural theories. Moreover, the neoclassical theory, with slight modification, can incorporate the ¿new economics of migration.' The major empirical problem confronting models of international labor migration is that migration flows are constrained by immigration policy. This policy, in turn, is influenced by various special interest groups. The direction and form of migration flows is conditioned by contemporary and historical relationships between source and destination countries." excerpt

  18. Globalisation and international migration in Asia.

    Science.gov (United States)

    Hugo, G

    1998-03-01

    "The present paper attempts to summarise the major contemporary trends in international migration in Asia and how this is related to the rapid demographic transition occurring across most of the region. The diversity of types of mobility is one of the striking features of Asian international migration and developments in each major type [are] discussed in the paper. It is then argued that there are elements within the Asian migration system that give it a momentum which to some extent operates outside of the influence of economic and political trends. Finally some emerging issues in Asian international migration are briefly addressed. These include the scale and effects of remittances, the feminisation of migration, undocumented migration, increasing government involvement and brain drain issues." (EXCERPT)

  19. Migration in Asia-Europe Relations

    DEFF Research Database (Denmark)

    Juego, Bonn

    2010-01-01

    There is a remarkable difference between viewing migration as a 'social integration' issue, on the one hand, and migration as a 'social relation'. The idea of ‘social integration’ has unrealistic assumptions that see migration as a one-way process, that societies and human relations are static......, and that migrants are mechanical. Policies that are founded on unrealistic assumptions are most likely to generate tensions, conflicts, and contradictions. For a migration process to succeed in forging social harmony and development, it is therefore of decisive and crucial importance to regard migration...... as a ‘social relation’. This is simply because successful migration has to be a harmonious synergy between the migrants (and also the sending countries where they come from) and the receiving society (and its people). As indicated, migrants enter into the receiving society not merely as a passive commodity...

  20. Political motivations for intra-European migration.

    Science.gov (United States)

    Bygnes, Susanne; Flipo, Aurore

    2017-08-01

    Motivations for migrating within the European Union have mainly been attributed to economic, career and lifestyle choices. This article suggests that political dissatisfaction is also an important motivator of recent intra-European migration. In our analysis of in-depth interviews with Romanian migrants in Spain and with Spanish migrants in Norway, we found a common emphasis on the political dimensions of their decision to migrate. In the interviews, the economic component of migration was often related to bad governance and negative perceptions of the state. The similarities of Spanish and Romanian migration narratives are especially striking because Spain and Romania represent substantially different migratory, political and economic contexts. However, migration is more obviously intertwined with conventional acts of political protest in the Spanish case. We suggest that differences in democratic contexts are pivotal in people's reactions to and framing of their deep dissatisfaction with domestic politics, as found in many European countries today.