WorldWideScience

Sample records for single biggest hurdle

  1. Evaluation of Single or Double Hurdle Sanitizer Applications in Simulated Field or Packing Shed Operations for Cantaloupes Contaminated with Listeria monocytogenes

    Cathy C. Webb

    2015-04-01

    Full Text Available Listeria monocytogenes contamination of cantaloupes has become a serious concern as contaminated cantaloupes led to a deadly outbreak in the United States in 2011. To reduce cross-contamination between cantaloupes and to reduce resident populations on contaminated melons, application of sanitizers in packing shed wash water is recommended. The sanitizing agent of 5% levulinic acid and 2% sodium dodecyl sulfate (SDS applied as a single hurdle in either a simulated dump or dip treatment significantly reduced L. monocytogenes to lower levels at the stem scar compared to a simulated dump treatment employing 200 ppm chlorine; however pathogen reductions on the rind tissue were not significantly different. Double hurdle approaches employing two sequential packing plant treatments with different sanitizers revealed decreased reduction of L. monocytogenes at the stem scar. In contrast, application of sanitizers both in the field and at the packing plant led to greater L. monocytogenes population reductions than if sanitizers were only applied at the packing plant.

  2. The world's biggest experiment

    Gregson, Liz

    2008-01-01

    According to CERN, our understanding of the Universe is about the change. Meet the Imperial alumni and staff who are involved in CERN's Large Hadron Collider, the world's biggest experiment. (3 pages)

  3. Biggest challenges in bioinformatics.

    Fuller, Jonathan C; Khoueiry, Pierre; Dinkel, Holger; Forslund, Kristoffer; Stamatakis, Alexandros; Barry, Joseph; Budd, Aidan; Soldatos, Theodoros G; Linssen, Katja; Rajput, Abdul Mateen

    2013-04-01

    The third Heidelberg Unseminars in Bioinformatics (HUB) was held on 18th October 2012, at Heidelberg University, Germany. HUB brought together around 40 bioinformaticians from academia and industry to discuss the 'Biggest Challenges in Bioinformatics' in a 'World Café' style event.

  4. Biggest challenges in bioinformatics

    Fuller, Jonathan C; Khoueiry, Pierre; Dinkel, Holger; Forslund, Kristoffer; Stamatakis, Alexandros; Barry, Joseph; Budd, Aidan; Soldatos, Theodoros G; Linssen, Katja; Rajput, Abdul Mateen

    2013-01-01

    The third Heidelberg Unseminars in Bioinformatics (HUB) was held in October at Heidelberg University in Germany. HUB brought together around 40 bioinformaticians from academia and industry to discuss the ‘Biggest Challenges in Bioinformatics' in a ‘World Café' style event.

  5. Technique of Hurdle Clearing in 400 Meters Hurdles (Study Review)

    Jakoubek, Jiří

    2017-01-01

    Title: Technique of Hurdle Clearing in 400 Meters Hurdles (Study Review) Authors: Jiří Jakoubek Supervisor: PhDr. Aleš Kaplan, Ph.D. Aims: The aim of this thesis is to describe technique of hurdle clearing in 400 meters hurdle race using study review and to examine this technique at particular athlete during training and racing sessions in 400 meters hurdles race. Methods: Technique was compared and examined at young athlete. Two kinograms were used for analysis, one from training and one fro...

  6. Technique of Hurdle Clearing in 400 Meters Hurdles

    Jakoubek, Jiří

    2018-01-01

    Title: Technique of Hurdle Clearing in 400 Meters Hurdles Authors: Jiří Jakoubek Supervisor: PhDr. Aleš Kaplan, Ph.D. Aims: The aim of this thesis is to describe technique of hurdle clearing in 400 meters hurdle race using study review and to examine this technique at particular athlete during training and racing sessions in 400 meters hurdles race. Methods: Technique was compared and examined at young athlete. Two kinograms were used for analysis, one from training and one from racing sessio...

  7. Hurdles in Basic Science Translation

    Christina J. Perry

    2017-07-01

    Full Text Available In the past century there have been incredible advances in the field of medical research, but what hinders translation of this knowledge into effective treatment for human disease? There is an increasing focus on the failure of many research breakthroughs to be translated through the clinical trial process and into medical practice. In this mini review, we will consider some of the reasons that findings in basic medical research fail to become translated through clinical trials and into basic medical practices. We focus in particular on the way that human disease is modeled, the understanding we have of how our targets behave in vivo, and also some of the issues surrounding reproducibility of basic research findings. We will also look at some of the ways that have been proposed for overcoming these issues. It appears that there needs to be a cultural shift in the way we fund, publish and recognize quality control in scientific research. Although this is a daunting proposition, we hope that with increasing awareness and focus on research translation and the hurdles that impede it, the field of medical research will continue to inform and improve medical practice across the world.

  8. Here, the biggest fridge in the world

    2006-01-01

    The Society "Air Liquide" has just finished, in CERN, the installation of the biggest and the most powerful cooling system in the world. This huge refrigerator will maintain the new particule accelerator at a temperature of 19, kelvin, thanks to liquide helium. (1 paragraphe

  9. Biggest bets in the universe unveiled

    Jamieson, Valerie

    2004-01-01

    Betting on the greatest unsolved problems in the universe is no longer the preserve of academic superstars such as Stephen Hawking. From Thursday, anyone will be able to place bets on whether the biggest physics experiments in the world will come good before 2010

  10. The Biggest Explosions in the Universe

    tion of stars. Biman Nath is an astrophysicist at the. Raman Research. Institute, Bangalore. G am m a ray bursts { w hich are ¯rst detected in energetic gam m a rays and w hich then glow in. X -ray, visible and radio w avelengths { are the result of the biggest explosions in the universe. A stronom ers w onder w hat causes ...

  11. Defining the critical hurdles in cancer immunotherapy

    Fox, Bernard A; Schendel, Dolores J; Butterfield, Lisa H

    2011-01-01

    of cancer immunotherapy. With consensus on these hurdles, international working groups could be developed to make recommendations vetted by the participating organizations. These recommendations could then be considered by regulatory bodies, governmental and private funding agencies, pharmaceutical...... immunotherapy organizations representing Europe, Japan, China and North America to discuss collaborations to improve development and delivery of cancer immunotherapy. One of the concepts raised by SITC and defined as critical by all parties was the need to identify hurdles that impede effective translation...... companies and academic institutions to facilitate changes necessary to accelerate clinical translation of novel immune-based cancer therapies. The critical hurdles identified by representatives of the collaborating organizations, now organized as the World Immunotherapy Council, are presented and discussed...

  12. The biggest problem of them all

    Anon.

    1984-01-01

    A resurgence of confidence in our understanding of basic processes has led to attention turning once again towards the Biggest Problem - the origins of the Universe. This new confidence was well demonstrated by a novel and intriguing symposium - 'Large Scale Structure of the Universe, Cosmology and Fundamental Physics', held at CERN last November, organized jointly by CERN and the European Southern Observatory (ESO). It brought together about 200 specialists, mainly from Europe and roughly equally divided between allegiances to particle physics, cosmology and astronomy

  13. The biggest problem of them all

    Anon.

    1984-01-15

    A resurgence of confidence in our understanding of basic processes has led to attention turning once again towards the Biggest Problem - the origins of the Universe. This new confidence was well demonstrated by a novel and intriguing symposium - 'Large Scale Structure of the Universe, Cosmology and Fundamental Physics', held at CERN last November, organized jointly by CERN and the European Southern Observatory (ESO). It brought together about 200 specialists, mainly from Europe and roughly equally divided between allegiances to particle physics, cosmology and astronomy.

  14. Defining the critical hurdles in cancer immunotherapy

    2011-01-01

    Scientific discoveries that provide strong evidence of antitumor effects in preclinical models often encounter significant delays before being tested in patients with cancer. While some of these delays have a scientific basis, others do not. We need to do better. Innovative strategies need to move into early stage clinical trials as quickly as it is safe, and if successful, these therapies should efficiently obtain regulatory approval and widespread clinical application. In late 2009 and 2010 the Society for Immunotherapy of Cancer (SITC), convened an "Immunotherapy Summit" with representatives from immunotherapy organizations representing Europe, Japan, China and North America to discuss collaborations to improve development and delivery of cancer immunotherapy. One of the concepts raised by SITC and defined as critical by all parties was the need to identify hurdles that impede effective translation of cancer immunotherapy. With consensus on these hurdles, international working groups could be developed to make recommendations vetted by the participating organizations. These recommendations could then be considered by regulatory bodies, governmental and private funding agencies, pharmaceutical companies and academic institutions to facilitate changes necessary to accelerate clinical translation of novel immune-based cancer therapies. The critical hurdles identified by representatives of the collaborating organizations, now organized as the World Immunotherapy Council, are presented and discussed in this report. Some of the identified hurdles impede all investigators; others hinder investigators only in certain regions or institutions or are more relevant to specific types of immunotherapy or first-in-humans studies. Each of these hurdles can significantly delay clinical translation of promising advances in immunotherapy yet if overcome, have the potential to improve outcomes of patients with cancer. PMID:22168571

  15. Defining the critical hurdles in cancer immunotherapy

    Fox Bernard A

    2011-12-01

    Full Text Available Abstract Scientific discoveries that provide strong evidence of antitumor effects in preclinical models often encounter significant delays before being tested in patients with cancer. While some of these delays have a scientific basis, others do not. We need to do better. Innovative strategies need to move into early stage clinical trials as quickly as it is safe, and if successful, these therapies should efficiently obtain regulatory approval and widespread clinical application. In late 2009 and 2010 the Society for Immunotherapy of Cancer (SITC, convened an "Immunotherapy Summit" with representatives from immunotherapy organizations representing Europe, Japan, China and North America to discuss collaborations to improve development and delivery of cancer immunotherapy. One of the concepts raised by SITC and defined as critical by all parties was the need to identify hurdles that impede effective translation of cancer immunotherapy. With consensus on these hurdles, international working groups could be developed to make recommendations vetted by the participating organizations. These recommendations could then be considered by regulatory bodies, governmental and private funding agencies, pharmaceutical companies and academic institutions to facilitate changes necessary to accelerate clinical translation of novel immune-based cancer therapies. The critical hurdles identified by representatives of the collaborating organizations, now organized as the World Immunotherapy Council, are presented and discussed in this report. Some of the identified hurdles impede all investigators; others hinder investigators only in certain regions or institutions or are more relevant to specific types of immunotherapy or first-in-humans studies. Each of these hurdles can significantly delay clinical translation of promising advances in immunotherapy yet if overcome, have the potential to improve outcomes of patients with cancer.

  16. THE BIGGEST EXPLOSIONS IN THE UNIVERSE

    Johnson, Jarrett L.; Whalen, Daniel J.; Smidt, Joseph; Even, Wesley; Fryer, Chris L.; Heger, Alex; Chen, Ke-Jung

    2013-01-01

    Supermassive primordial stars are expected to form in a small fraction of massive protogalaxies in the early universe, and are generally conceived of as the progenitors of the seeds of supermassive black holes (BHs). Supermassive stars with masses of ∼55, 000 M ☉ , however, have been found to explode and completely disrupt in a supernova (SN) with an energy of up to ∼10 55 erg instead of collapsing to a BH. Such events, ∼10, 000 times more energetic than typical SNe today, would be among the biggest explosions in the history of the universe. Here we present a simulation of such a SN in two stages. Using the RAGE radiation hydrodynamics code, we first evolve the explosion from an early stage through the breakout of the shock from the surface of the star until the blast wave has propagated out to several parsecs from the explosion site, which lies deep within an atomic cooling dark matter (DM) halo at z ≅ 15. Then, using the GADGET cosmological hydrodynamics code, we evolve the explosion out to several kiloparsecs from the explosion site, far into the low-density intergalactic medium. The host DM halo, with a total mass of 4 × 10 7 M ☉ , much more massive than typical primordial star-forming halos, is completely evacuated of high-density gas after ∼ ☉ after ∼> 70 Myr. The chemical signature of supermassive star explosions may be found in such long-lived second-generation stars today

  17. Tohoku Women's Hurdling Project: Science Angels (abstract)

    Mizuki, Kotoe; Watanabe, Mayuko

    2009-04-01

    Tohoku University was the first National University to admit three women students in Japan in 1913. To support the university's traditional ``open-door'' policy, various projects have been promoted throughout the university since its foundation. A government plan, the Third-Stage Basic Plan for Science and Technology, aims to increase the women scientist ratio up to 25% nationwide. In order to achieve this goal, the Tohoku Women's Hurdling Project, funded by the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT), was adopted in 2006. This project is threefold: support for child/family, improvement of facilities, and support for the next generation, which includes our Science Angels program. ``Science Angels'' are women PhD students appointed by the university president, with the mission to form a strong support system among each other and to become role-models to inspire younger students who want to become researchers. Currently, 50 women graduate students of the natural sciences are Science Angels and are encouraged to design and deliver lectures in their areas of specialty at their alma maters. Up to now, 12 lectures have been delivered and science events for children in our community have been held-all with great success.

  18. Examining Teachers' Hurdles to `Science for All'

    Southerland, Sherry; Gallard, Alejandro; Callihan, Laurie

    2011-11-01

    The goal of this research is to identify science teachers' beliefs and conceptions that play an important role in shaping their understandings of and attempts to enact inclusive science teaching practices. We examined the work products, both informal (online discussions, email exchanges) and formal (papers, unit plans, peer reviews), of 14 teachers enrolled in a master's degree course focused on diversity in science teaching and learning. These emerging understandings were member-checked via a series of interviews with a subset of these teachers. Our analysis was conducted in two stages: (1) describing the difficulties the teachers identified for themselves in their attempts to teach science to a wide range of students in their classes and (2) analyzing these self-identified barriers for underlying beliefs and conceptions that serve to prohibit or allow for the teachers' understanding and enactment of equitable science instruction. The teachers' self-identified barriers were grouped into three categories: students, broader social infrastructure, and self. The more fundamental barriers identified included teacher beliefs about the ethnocentrism of the mainstream, essentialism/individualism, and beliefs about the meritocracy of schooling. The implications of these hurdles for science teacher education are discussed.

  19. CERN’s biggest and youngest family

    Panos Charitos for PH News

    2013-01-01

    In a sort of happy reply to the CERN Director-General, who cited them as the summer “addition to the big CERN family”, some of the 2013 summer students submitted their enthusiastic messages to the PH Newsletter. There is no way to include all of them in a single article. Instead, a world map will do the job. Click on it and enjoy the messages from the youngest part of the big CERN family.   Every summer CERN turns into one of the most international and lively places you could imagine as hundreds of summer students arrive from all over the world. Students from different backgrounds spend a few weeks working with their supervisors on numerous topics of scientific research. Among this year's summer students you will meet an astronomer, a biochemist, a computational biologist and even an Olympic winner! These are young scientists with an incredible amount of talent, intelligence and energy. CERN summer students clearly have an e...

  20. Effect of Hurdle Technology in Food Preservation: A Review.

    Singh, Shiv; Shalini, Rachana

    2016-01-01

    Hurdle technology is used in industrialized as well as in developing countries for the gentle but effective preservation of foods. Hurdle technology was developed several years ago as a new concept for the production of safe, stable, nutritious, tasty, and economical foods. Previously hurdle technology, i.e., a combination of preservation methods, was used empirically without much knowledge of the governing principles. The intelligent application of hurdle technology has become more prevalent now, because the principles of major preservative factors for foods (e.g., temperature, pH, aw, Eh, competitive flora), and their interactions, became better known. Recently, the influence of food preservation methods on the physiology and behavior of microorganisms in foods, i.e. their homeostasis, metabolic exhaustion, stress reactions, are taken into account, and the novel concept of multi-target food preservation emerged. The present contribution reviews the concept of the potential hurdles for foods, the hurdle effect, and the hurdle technology for the prospects of the future goal of a multi-target preservation of foods.

  1. Organizing a Community "Biggest Loser" Weight Loss Challenge

    Jensen, Kirstin D.

    2013-01-01

    The program described here shows how Extension can be a strong collaborative partner in a rural setting in improving the overall health of the community by organizing a three month "Biggest Loser" Weight Loss Challenge. A pre-and post-fitness assessment and bi-weekly weigh-ins were administered. Three healthy lifestyle educational…

  2. Preservation of South African steamed bread using hurdle technology

    Lombard, GE

    2000-01-01

    Full Text Available was the most effective hurdle. Glycerol levels of 150 and 180 g/kg flour produced a(w) levels of 0.908 and 0.880, respectively, which were sufficient to inhibit C. botulinum yeast and moulds were effectively inhibited during the shelf life study. Staling...

  3. BIGGEST CZECH BANKS IN THE MIRROR OF ANNUAL REPORTS

    Vladislav PAVLAT

    2016-02-01

    Full Text Available The aim of the Paper is to characterise and analyse the biggest Czech banks Annual reports (ARs. Since 2004, the behaviour of Czech banks has been changing, as can be seen – inter alia - from the big banks´ financial statements and annual reports. During the period of 2007 – 2013 the implementation of IFRS continued and its impact on the institutional structure of banking is visible. From the point of view of banks, annual reports present not only the financial results, but they serve as an important instrument of competition and marketing as well. Comparative analysis of the three Czech leading banks gives a picture of their specific features as reflected in their annual statements.

  4. GPU: the biggest key processor for AI and parallel processing

    Baji, Toru

    2017-07-01

    Two types of processors exist in the market. One is the conventional CPU and the other is Graphic Processor Unit (GPU). Typical CPU is composed of 1 to 8 cores while GPU has thousands of cores. CPU is good for sequential processing, while GPU is good to accelerate software with heavy parallel executions. GPU was initially dedicated for 3D graphics. However from 2006, when GPU started to apply general-purpose cores, it was noticed that this architecture can be used as a general purpose massive-parallel processor. NVIDIA developed a software framework Compute Unified Device Architecture (CUDA) that make it possible to easily program the GPU for these application. With CUDA, GPU started to be used in workstations and supercomputers widely. Recently two key technologies are highlighted in the industry. The Artificial Intelligence (AI) and Autonomous Driving Cars. AI requires a massive parallel operation to train many-layers of neural networks. With CPU alone, it was impossible to finish the training in a practical time. The latest multi-GPU system with P100 makes it possible to finish the training in a few hours. For the autonomous driving cars, TOPS class of performance is required to implement perception, localization, path planning processing and again SoC with integrated GPU will play a key role there. In this paper, the evolution of the GPU which is one of the biggest commercial devices requiring state-of-the-art fabrication technology will be introduced. Also overview of the GPU demanding key application like the ones described above will be introduced.

  5. Extension of Space Food Shelf Life Through Hurdle Approach

    Cooper, M. R.; Sirmons, T. A.; Froio-Blumsack, D.; Mohr, L.; Young, M.; Douglas, G. L.

    2018-01-01

    The processed and prepackaged space food system is the main source of crew nutrition, and hence central to astronaut health and performance. Unfortunately, space food quality and nutrition degrade to unacceptable levels in two to three years with current food stabilization technologies. Future exploration missions will require a food system that remains safe, acceptable and nutritious through five years of storage within vehicle resource constraints. The potential of stabilization technologies (alternative storage temperatures, processing, formulation, ingredient source, packaging, and preparation procedures), when combined in hurdle approach, to mitigate quality and nutritional degradation is being assessed. Sixteen representative foods from the International Space Station food system were chosen for production and analysis and will be evaluated initially and at one, three, and five years with potential for analysis at seven years if necessary. Analysis includes changes in color, texture, nutrition, sensory quality, and rehydration ratio when applicable. The food samples will be stored at -20 C, 4 C, and 21 C. Select food samples will also be evaluated at -80 C to determine the impacts of ultra-cold storage after one and five years. Packaging film barrier properties and mechanical integrity will be assessed before and after processing and storage. At the study conclusion, if tested hurdles are adequate, formulation, processing, and storage combinations will be uniquely identified for processed food matrices to achieve a five-year shelf life. This study will provide one of the most comprehensive investigations of long duration food stability ever completed, and the achievement of extended food system stability will have profound impacts to health and performance for spaceflight crews and for relief efforts and military applications on Earth.

  6. THERAPEUTIC ANTISENSE OLIGONUCLEOTIDES AGAINST CANCER: HURDLING TO THE CLINIC

    Pedro Miguel Duarte Moreno

    2014-10-01

    Full Text Available Under clinical development since the early 90’s and with two successfully approved drugs (Fomivirsen and Mipomersen, oligonucleotide-based therapeutics have not yet delivered a clinical drug to the market in the cancer field. Whilst many pre-clinical data has been generated, a lack of understanding still exists on how to efficiently tackle all the different challenges presented for cancer targeting in a clinical setting. Namely, effective drug vectorization, careful choice of target gene or synergistic multi-gene targeting are surely decisive, while caution must be exerted to avoid potential toxic, often misleading off-target-effects. Here a brief overview will be given on the nucleic acid chemistry advances that established oligonucleotide technologies as a promising therapeutic alternative and ongoing cancer related clinical trials. Special attention will be given towards a perspective on the hurdles encountered specifically in the cancer field by this class of therapeutic oligonucleotides and a view on possible avenues for success is presented, with particular focus on the contribution from nanotechnology to the field.

  7. Hurdling barriers through market uncertainty: Case studies ininnovative technology adoption

    Payne, Christopher T.; Radspieler Jr., Anthony; Payne, Jack

    2002-08-18

    The crisis atmosphere surrounding electricity availability in California during the summer of 2001 produced two distinct phenomena in commercial energy consumption decision-making: desires to guarantee energy availability while blackouts were still widely anticipated, and desires to avoid or mitigate significant price increases when higher commercial electricity tariffs took effect. The climate of increased consideration of these factors seems to have led, in some cases, to greater willingness on the part of business decision-makers to consider highly innovative technologies. This paper examines three case studies of innovative technology adoption: retrofit of time-and-temperature signs on an office building; installation of fuel cells to supply power, heating, and cooling to the same building; and installation of a gas-fired heat pump at a microbrewery. We examine the decision process that led to adoption of these technologies. In each case, specific constraints had made more conventional energy-efficient technologies inapplicable. We examine how these barriers to technology adoption developed over time, how the California energy decision-making climate combined with the characteristics of these innovative technologies to overcome the barriers, and what the implications of hurdling these barriers are for future energy decisions within the firms.

  8. Crveno jezero - the biggest sinkhole in Dinaric Karst (Croatia)

    Garasic, M.

    2012-04-01

    Crveno jezero is a karst phenomenon known throughout the world for its size and specific features. In the course of the 1950's, some hydrological measurements were made on the surface of the lake, including depth measurement at 39 points (academician M. Petrik and his associates). The information about the maximum depth of 254 meters actually originates from that research (PETRIK, 1960). This depth has been "attracting" geologists, hydrogeologists and speleologists for many years now. On numerous occasions, people descended to the surface of the lake but, in the period prior to speleohydrogeological research conducted in 1998, no attempt had been made to dive underwater and document the lake depth, nor to investigate by other methods the interior of the lake and give a scientifically documented representation of this karst phenomenon from the speleohydrogeological aspect (GARAŠIĆ, 2000; 2001). The Red Lake, located one kilometer to the west of Imotski, is the biggest of all lakes situated in the area (featuring 18 big or small dry or water-filled depressions) and this by both its visible (superficial) and invisible (submerged) portions. Its name originates from red rocks perched on cliffs extending to more than 250 meters in height. The lake color is dark blue, and it measures about 150 x 180 meters, depending on water level, i.e. on the time of the year. The easiest way to reach the lake (belay, descend and ascend with ropes) is to approach it from the east side. Here we have a vertical cliff about 60 meters in height, followed by 300 meters of a very steep soil creep zone, after which there is yet another vertical cliff of at least ten meters in height (depending on lake water level). In other words, a special descending technique must be used to access any point along the lake perimeter in summer months. Vertical and overhanging cliffs rising above the surface of the lake range from 160 to 250 meters in height. However, the depth of the lake is even more

  9. Effects of Biggest Loser exercise depictions on exercise-related attitudes.

    Berry, Tanya R; McLeod, Nicole C; Pankratow, Melanie; Walker, Jessica

    2013-01-01

    To examine whether participants who watched an exercise-related segment of The Biggest Loser television program would have different explicit and implicit affective exercise-related attitudes than those of control participants. University students (N=138) watched a clip of The Biggest Loser or American Idol, then completed a Go/No-go Association Task, a thought-listing task, and questionnaires measuring explicit attitudes, activity level, and mood. Participants who watched The Biggest Loser had significantly lower explicit, but not implicit, attitudes towards exercise than did control participants. There is a need to examine the influence of popular media depictions of exercise.

  10. Women's Health: The Biggest Threats to Women's Health are often Preventable.

    Healthy Lifestyle Women's health The biggest threats to women's health are often preventable. Here's what you need to know to live ... Clinic Staff Many of the leading threats to women's health can be prevented — if you know how. ...

  11. Time: The Biggest Pattern in Natural History Research

    Gontier, Nathalie

    2016-10-01

    We distinguish between four cosmological transitions in the history of Western intellectual thought, and focus on how these cosmologies differentially define matter, space and time. We demonstrate that how time is conceptualized significantly impacts a cosmology's notion on causality, and hone in on how time is conceptualized differentially in modern physics and evolutionary biology. The former conflates time with space into a single space-time continuum and focuses instead on the movement of matter, while the evolutionary sciences have a tradition to understand time as a given when they cartography how organisms change across generations over or in time, thereby proving the phenomenon of evolution. The gap becomes more fundamental when we take into account that phenomena studied by chrono-biologists demonstrate that numerous organisms, including humans, have evolved a "sense" of time. And micro-evolutionary/genetic, meso-evolutionary/developmental and macro-evolutionary phenomena including speciation and extinction not only occur by different evolutionary modes and at different rates, they are also timely phenomena that follow different periodicities. This article focusses on delineating the problem by finding its historical roots. We conclude that though time might be an obsolete concept for the physical sciences, it is crucial for the evolutionary sciences where evolution is defined as the change that biological individuals undergo in/over or through time.

  12. Hurdle technology to preserve the 'Golden' papaya post harvest quality

    Molinari, Andrea Cristina Fialho

    2007-01-01

    differences among papayas submitted to different treatments. A synergism was verified on the techniques combination, with the best results obtained from the association of CP + PEabs + gamma-irradiation at 0.4 kGy, which reached a total storage period of 35 days. Thus, that is the post harvest hurdle technology recommend for exporting 'Golden' papayas to markets with quarantine restrictions to fruit-flies (author)

  13. Quality of hurdle treated pork sausages during refrigerated (4 ± 1°C) storage.

    Thomas, R; Anjaneyulu, A S R; Kondaiah, N

    2010-06-01

    Pork sausages developed using hurdle technology was evaluated during refrigerated storage (4 ± 1°C). Hurdles incorporated were low pH, low water activity, vacuum packaging and post package reheating. Dipping in potassium sorbate solution prior to vacuum packaging was also tried. Hurdle treatment significantly (p sausages during storage, as indicated by TBARS and tyrosine values. Incorporation of hurdles decreased the growth of different spoilage and pathogenic microorganisms. Combination of pH, water activity, vacuum packaging and reheating inhibited the growth of yeast and molds up to 12 days, while additional dipping of sausages in 1% potassium sorbate solution prior to packaging inhibited their growth even on 30(th) day of storage. Incorporation of hurdles resulted in initial reduction in all the sensory attributes, but they helped to maintain these attributes for significantly longer period compared to control. Hurdle treated sausages exhibited no spoilage signs even on day 30, while the control sausages were found acceptable only up to 18 days.

  14. Biggest Threats

    ... Resistant Tuberculosis HAI/AR Prevention Programs Supporting Advances & Innovations to Slow AR Funding Announcements Federal Engagement in ... Word file Microsoft Excel file Audio/Video file Apple Quicktime file RealPlayer file Text file Zip Archive ...

  15. Censored Hurdle Negative Binomial Regression (Case Study: Neonatorum Tetanus Case in Indonesia)

    Yuli Rusdiana, Riza; Zain, Ismaini; Wulan Purnami, Santi

    2017-06-01

    Hurdle negative binomial model regression is a method that can be used for discreate dependent variable, excess zero and under- and overdispersion. It uses two parts approach. The first part estimates zero elements from dependent variable is zero hurdle model and the second part estimates not zero elements (non-negative integer) from dependent variable is called truncated negative binomial models. The discrete dependent variable in such cases is censored for some values. The type of censor that will be studied in this research is right censored. This study aims to obtain the parameter estimator hurdle negative binomial regression for right censored dependent variable. In the assessment of parameter estimation methods used Maximum Likelihood Estimator (MLE). Hurdle negative binomial model regression for right censored dependent variable is applied on the number of neonatorum tetanus cases in Indonesia. The type data is count data which contains zero values in some observations and other variety value. This study also aims to obtain the parameter estimator and test statistic censored hurdle negative binomial model. Based on the regression results, the factors that influence neonatorum tetanus case in Indonesia is the percentage of baby health care coverage and neonatal visits.

  16. The Biggest Mover: Empowering Students with Intellectual and Developmental Delays and Physical Challenges

    Brown, Michelle J.

    2018-01-01

    The Biggest Mover Program, an educational program to improve daily exercise and healthy eating was developed to address the learning needs of students with intellectual and developmental disabilities and physical challenges. The program was part of a three-part program to improve the knowledge of students, staff, and teachers through the use of…

  17. No clear winner: effects of The Biggest Loser on the stigmatization of obese persons.

    Yoo, Jina H

    2013-01-01

    Previous research has largely ignored the question of whether watching reality weight-loss TV shows influences viewers to form a negative obesity stereotype. This study examines antecedents and outcomes of watching The Biggest Loser with the Orientation1-Stimulus-Orientation2-Response (O-S-O-R) model. The study found that individuals who are more concerned with their weight (O1) watch more episodes of The Biggest Loser (S). Meanwhile, consumption of The Biggest Loser leads to greater perceived locus of weight control (O2), indicating that body weight is under personal control. Perceived locus of weight control, in turn, significantly predicts the attribution of obesity to personal responsibility (R). Ultimately, attributing obesity to personal responsibility leads to the formation of anti-fat attitudes (R). This study offers an integrative theoretical framework to investigate media effects on the formation of an obesity stigma by using the O-S-O-R model. The results imply that certain lifestyle transformation media, such as The Biggest Loser, might reinforce the notion that individuals control their own weight and thus further amplify the obesity stigma.

  18. Kinetic and kinematic analysis of hurdle clearance of an African and ...

    The results showed a difference in the centre of mass displacement at hurdle clearance and velocity-parameters in both the take-off and the landing phases. When comparing R.G to C.J, the latter had a smaller vertical displacement and a longer horizontal displacement, in addition to, a greater horizontal velocity along with ...

  19. Jumping the PBL Implementation Hurdle: Supporting the Efforts of K-12 Teachers

    Ertmer, Peggy A.; Simons, Krista D.

    2006-01-01

    While problem-based learning (PBL) has a relatively long history of successful use in medical and pre-professional schools, it has yet to be widely adopted by K--12 teachers. This may be due, in part, to the numerous challenges teachers experience when implementing PBL. In this paper, we describe specific hurdles that teachers are likely to…

  20. Hurdles in clinical implementation of academic advanced therapy medicinal products: A national evaluation.

    de Wilde, Sofieke; Veltrop-Duits, Louise; Hoozemans-Strik, Merel; Ras, Thirza; Blom-Veenman, Janine; Guchelaar, Henk-Jan; Zandvliet, Maarten; Meij, Pauline

    2016-06-01

    Since the implementation of the European Union (EU) regulation for advanced therapy medicinal products (ATMPs) in 2009, only six ATMPs achieved marketing authorization approval in the EU. Recognizing the major developments in the ATMP field, starting mostly in academic institutions, we investigated which hurdles were experienced in the whole pathway of ATMP development towards clinical care. Quality interviews were executed with different stakeholders in The Netherlands involved in the ATMP development field, e.g. academic research groups, national authorities and patient organizations. Based on the hurdles mentioned in the interviews, questionnaires were subsequently sent to the academic principal investigators (PIs) and ATMP good manufacturing practice (GMP) facility managers to quantify these hurdles. Besides the familiar regulatory routes of marketing authorization (MA) and hospital exemption (HE), a part of the academic PIs perceived that ATMPs should become available by the Tissues and Cells Directive or did not anticipate on the next development steps towards implementation of their ATMP towards regular clinical care. The main hurdles identified were: inadequate financial support, rapidly evolving field, study-related problems, lacking regulatory knowledge, lack of collaborations and responsibility issues. Creating an academic environment stimulating and planning ATMP development and licensing as well as investing in expanding the relevant regulatory knowledge in academic institutions seems a prerequisite to develop ATMPs from bench to patient. Copyright © 2016 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

  1. BiGGEsTS: integrated environment for biclustering analysis of time series gene expression data

    Madeira Sara C

    2009-07-01

    Full Text Available Abstract Background The ability to monitor changes in expression patterns over time, and to observe the emergence of coherent temporal responses using expression time series, is critical to advance our understanding of complex biological processes. Biclustering has been recognized as an effective method for discovering local temporal expression patterns and unraveling potential regulatory mechanisms. The general biclustering problem is NP-hard. In the case of time series this problem is tractable, and efficient algorithms can be used. However, there is still a need for specialized applications able to take advantage of the temporal properties inherent to expression time series, both from a computational and a biological perspective. Findings BiGGEsTS makes available state-of-the-art biclustering algorithms for analyzing expression time series. Gene Ontology (GO annotations are used to assess the biological relevance of the biclusters. Methods for preprocessing expression time series and post-processing results are also included. The analysis is additionally supported by a visualization module capable of displaying informative representations of the data, including heatmaps, dendrograms, expression charts and graphs of enriched GO terms. Conclusion BiGGEsTS is a free open source graphical software tool for revealing local coexpression of genes in specific intervals of time, while integrating meaningful information on gene annotations. It is freely available at: http://kdbio.inesc-id.pt/software/biggests. We present a case study on the discovery of transcriptional regulatory modules in the response of Saccharomyces cerevisiae to heat stress.

  2. CONFLICTS AND OPERATIONAL HURDLES IN THE MANAGEMENT OF INNOVATIVE PROJECTS: AN EMPIRICAL STUDY

    José Varela Donato

    2013-12-01

    Full Text Available This article aims at describing how conflicts and operational hurdles manifest themselves in the management of innovative projects in a development bank (DB. The research characterizes itself as a qualitative and exploratory approach; the data collection consisted of interviews with consultants and project managers and by documents on management projects in Development Bank; the interviews have undergone the content analysis by utilizing the Atlas.ti. The research revealed that the project management in its new implemented model faces difficulties similar to those observed in traditional hierarchies. It was observed that conflicts regarding interests, values, psychological aspects and operational hurdles are intrinsic to the life cycle of innovative projects, which implementation requires a lot of political capacity from their leaders to be effective.

  3. Probability as a conceptual hurdle to understanding one-dimensional quantum scattering and tunnelling

    Domert, Daniel; Linder, Cedric; Ingerman, Ake

    2005-01-01

    This paper draws on part of a larger project looking at university students' learning difficulties associated with quantum mechanics. Here an unexpected and interesting aspect was brought to the fore while students were discussing a computer simulation of one-dimensional quantum scattering and tunnelling. In these explanations the most dominant conceptual hurdle that emerged in the students' explanations was centred around the notion of probability. To explore this further, categories of description of the variation in the understanding of probability were constituted. The analysis reported is done in terms of the various facets of probability encountered in the simulation and characterizes dynamics of this conceptual hurdle to appropriate understanding of the scattering and tunnelling process. Pedagogical implications are discussed

  4. Lactic Acid Bacteria Selection for Biopreservation as a Part of Hurdle Technology Approach Applied on Seafood

    Norman Wiernasz

    2017-05-01

    Full Text Available As fragile food commodities, microbial, and organoleptic qualities of fishery and seafood can quickly deteriorate. In this context, microbial quality and security improvement during the whole food processing chain (from catch to plate, using hurdle technology, a combination of mild preserving technologies such as biopreservation, modified atmosphere packaging, and superchilling, are of great interest. As natural flora and antimicrobial metabolites producers, lactic acid bacteria (LAB are commonly studied for food biopreservation. Thirty-five LAB known to possess interesting antimicrobial activity were selected for their potential application as bioprotective agents as a part of hurdle technology applied to fishery products. The selection approach was based on seven criteria including antimicrobial activity, alteration potential, tolerance to chitosan coating, and superchilling process, cross inhibition, biogenic amines production (histamine, tyramine, and antibiotics resistance. Antimicrobial activity was assessed against six common spoiling bacteria in fishery products (Shewanella baltica, Photobacterium phosphoreum, Brochothrix thermosphacta, Lactobacillus sakei, Hafnia alvei, Serratia proteamaculans and one pathogenic bacterium (Listeria monocytogenes in co-culture inhibitory assays miniaturized in 96-well microtiter plates. Antimicrobial activity and spoilage evaluation, both performed in cod and salmon juice, highlighted the existence of sensory signatures and inhibition profiles, which seem to be species related. Finally, six LAB with no unusual antibiotics resistance profile nor histamine production ability were selected as bioprotective agents for further in situ inhibitory assays in cod and salmon based products, alone or in combination with other hurdles (chitosan, modified atmosphere packing, and superchilling.

  5. Sustainable energy policy for Asia: Mitigating systemic hurdles in a highly dense city

    Ng, Artie W.; Nathwani, Jatin

    2010-01-01

    Greenhouse gas emission (GHG) has been increasingly a sensitive issue that is across border and impacting global public interests. While the use of renewable energy technology is perceived as a means to enable delivery of emission-free solutions, its penetration into the energy market has not been timely and significant enough as projected in prior studies. This article aims to illustrate some of the critical hurdles as the policy makers start formulating environmentally friendly energy consumption means for the public in Asian economies. In particular, through analyzing the characteristics in the case of Hong Kong, the authors unveil the challenges for this highly dense city to reach a landscape of alternative energy resources for its transition into a sustainable economy. Education and engagement with the public about a sustainable future, alignment of stakeholders' economic interests and absorption capacity of emerging technologies are argued as the three main challenges and initiatives in mitigating the underlying systemic hurdles that remain to be overcome. Observing the current responses to the externalities by the policy makers in Hong Kong, this study articulates the critical challenges to mitigate these specific systemic hurdles embedded in the existing infrastructure of a highly dense city. Possible mitigating measures to enable deployment of integrative sustainable energy solutions in dealing with climate change are discussed. (author)

  6. Driving force of organic fertilizer use in Central Rift Valley of Ethiopia: Independent double hurdle approach

    Terefe Aemro T.

    2016-01-01

    Full Text Available The objective of this study was to identify the important factors that influence both adoption and level of use of organic fertilizer among smallholder farmers in the Central Rift Valley of Ethiopia using a primary data collected from 161 sample respondents. An independent double hurdle model was used to address the objectives of the study on the assumption that adoption and level of organic fertilizer use by are two independent decisions influenced by different factors. Empirical estimates of the first hurdle reveals that literacy status of the head, livestock holding, frequency of extension contact, distance to market and slope of the plot are statistically significant decision variables that affect the probability of adopting organic fertilizer. Meanwhile, estimates of the second hurdle revealed that, the extent of use of organic fertilizer was determined by livestock holding, access to credit distance to the market and slope of plot. This indicates that factors that affect adoption are not necessarily the same as those that influence intensity. Therefore, it is important to consider both stages in evaluating strategies aimed at promoting the adoption and use of organic fertilizer.

  7. Ground Handling Business at Non-European Biggest World Airports as a Problem of Market Structures

    Anna Tomová

    2015-12-01

    Full Text Available In the paper we analyse the market structures of ground handling at the biggest non-European passenger and cargo airports in accordance with the ACI list of the most important world airports in 2014. Using the IATA IGHC database as of spring 2015, our analysis revealed that out of Europe double digit numbers of providers are rare what contrasts with situation in Europe where ground handling markets were deregulated by the Council Directive 96/67/EC. The analysis also brought that the monopolistic structures of ground handling markets were more specific for the regions of Asia and the Middle East. Airports as ground handling providers were not found within the analysed sample in North America, Latin America, Africa and Australia and Oceania, while this arrangement was to a larger extent present at the analysed Asian airports. Asia and the Middle East biggest airports are identified by us as candidates for further deregulation of ground handling arguing by forecasted demand for air services in the regions, although expected deregulation may be curbed by national regulators.

  8. Total Quality Management in Higher Education: Clearing the Hurdles. A Survey on Strategies for Implementing Quality Management Practices in Higher Education. A GOAL/QPC Application Report.

    Seymour, Daniel

    Based on a survey of Quality Management (QM) practitioners at 21 colleges, this study presents the 10 most difficult implementation hurdles to QM in higher education and a set of hurdle-clearing strategies. The hurdles are: (1) lack of time to implement QM; (2) perception that QM is something for janitorial and housing staffs but not applicable to…

  9. Hurdles to the global antipolio campaign in Pakistan: an outline of the current status and future prospects to achieve a polio free world.

    Khan, Tariq; Qazi, Javaria

    2013-08-01

    The Global Polio Eradication Initiative to eradicate polio completely by the year 2000 has been successful, except for three endemic and some non-endemic countries. Pakistan, one of the three endemic polio reservoirs, is posing a serious threat to the success of the initiative. Currently, the expanded programme on immunisation has been geared to win the race over polio virus in Pakistan. After the remarkable decrease in polio cases from 198 in 2011 to only 58 in 2012, Pakistan seemed to be at the verge of success. However, hurdles continue to retard the campaign. The war against terrorism, misconceptions about polio vaccine, religious misinterpretations, frustration among vaccinators, lack of awareness, social considerations, natural calamities, inaccessibility, and inefficient vaccines and so on are continually rupturing the foundations of the worldwide initiative in the country. Weak health management is found at the hub of majority of the challenges. Stricter policies, well managed and supervised plans and strategic actions, risk analysis and enhanced communication may help giving the final punch to polio virus in the country. Analysis suggested that there is some literature available on the challenges to polio elimination, yet there is not a single publication up to date that considers all the possible hurdles in a single manuscript. This paper sorts out the breaches that hamper the goal of eliminating polio from Pakistan. We have evaluated all the possible barriers and explained them with a perspective that will help develop area specific strategies against polio virus and thus eradicate polio virus from the world.

  10. FDA Guidance on Biosimilar Interchangeability Elicits Diverse Views: Current and Potential Marketers Complain About Too-High Hurdles.

    Barlas, Stephen

    2017-08-01

    Pharmaceutical industry sectors are at odds as the Food and Drug Administration seeks to define "interchangeability" for biosimilars. The battle lines vary by topic, but biosimilar marketers, health plans, and drugstores are generally urging lower hurdles.

  11. The three hurdles of tax planning: How business context, aims of tax planning, and tax manager power affect tax

    Feller, Anna; Schanz, Deborah

    2014-01-01

    The question of why some companies pay more taxes than others is a widely investigated topic of interest. One of the famous suspect explanations is a phenomenon called tax avoidance. We develop a holistic theoretical concept of influences on corporate tax planning through a series of 19 in-depth German tax expert interviews. Our findings show that three distinct hurdles in the tax planning process can explain different levels of tax expense across companies. Those three hurdles are which tax ...

  12. Edutainment's Impact on Health Promotion: Viewing The Biggest Loser Through the Social Cognitive Theory.

    Mocarski, Richard; Bissell, Kimberly

    2016-01-01

    Through a critical rhetorical analysis using Bandura's social cognitive theory as a lens to view The Biggest Loser (TBL), this article illustrates the contradictions between the show's health promotional aims and its entertainment aims, which show the problems the show creates for health promotion practitioners working on obesity. The social cognitive theory constructs of observational learning, psychological determinants, and environmental determinants emerged from this reading of TBL as central to how the show masquerades as a health promotion tool. This reading reveals that TBL promotes a neoliberal construction of health and obesity that challenges the worldview that many health promotion campaigns take and, therefore, complicates our own efforts to combat obesity. With this revealed, it is suggested that TBL be incorporated into health promotion campaigns only as a foil. © 2015 Society for Public Health Education.

  13. Non Invasive Instrumentation For Single Event Effects (NIISEE), Phase I

    National Aeronautics and Space Administration — On this Phase 1 project, Adventium will identify and address key hurdles to achieve Radiation Hardening by Software (RHS) for Single Event Effects (SEEs) for modern...

  14. Some findings on zero-inflated and hurdle poisson models for disease mapping.

    Corpas-Burgos, Francisca; García-Donato, Gonzalo; Martinez-Beneito, Miguel A

    2018-05-27

    Zero excess in the study of geographically referenced mortality data sets has been the focus of considerable attention in the literature, with zero-inflation being the most common procedure to handle this lack of fit. Although hurdle models have also been used in disease mapping studies, their use is more rare. We show in this paper that models using particular treatments of zero excesses are often required for achieving appropriate fits in regular mortality studies since, otherwise, geographical units with low expected counts are oversmoothed. However, as also shown, an indiscriminate treatment of zero excess may be unnecessary and has a problematic implementation. In this regard, we find that naive zero-inflation and hurdle models, without an explicit modeling of the probabilities of zeroes, do not fix zero excesses problems well enough and are clearly unsatisfactory. Results sharply suggest the need for an explicit modeling of the probabilities that should vary across areal units. Unfortunately, these more flexible modeling strategies can easily lead to improper posterior distributions as we prove in several theoretical results. Those procedures have been repeatedly used in the disease mapping literature, and one should bear these issues in mind in order to propose valid models. We finally propose several valid modeling alternatives according to the results mentioned that are suitable for fitting zero excesses. We show that those proposals fix zero excesses problems and correct the mentioned oversmoothing of risks in low populated units depicting geographic patterns more suited to the data. Copyright © 2018 John Wiley & Sons, Ltd.

  15. “That’s the biggest impact!” Pedagogical values of movies in ELT classrooms

    Nyak Mutia Ismail

    2017-09-01

    Full Text Available Since many say watching movies can have a positive effect on language learning outcomes, this research was done to find out which skills movies can contribute most to, whether speaking, listening, reading, writing, vocabulary, grammar or cultural aspects. A qualitative research method was used for this study. This study was done to find out the teachers’ perceptions of using English movies in English Language Teaching (ELT processes. Teachers from three different levels: primary, secondary, and senior high-school teachers were asked to answer a questionnaire set in accordance with the research topic. Five of them were senior high school teachers, two of them were junior high school teachers, and three of them were elementary school teachers. Creative interviews were also used as an additional data source. The results showed that most of the teachers agreed that movies play their biggest role and considerable advantages in developing cultural aspects and listening skills. Furthermore, some integration is possible between listening and speaking as well as with reading and writing because watching movies works better with integration of skills. Apparently, even though vocabulary can develop with this technique, grammar is not enhanced alone without being accompanied by writing.

  16. MONITORING OF A GLUTEN CONTENT IN SELECTED MEAT PRODUCTS FROM THREE BIGGEST MEAT PRODUCERS IN SLOVAKIA

    Ladislav Staruch

    2012-02-01

    Full Text Available The work is focused on a monitoring of a gluten content in selected meat products from three biggest and most popular meat producers in Slovakia. Gluten is a type of protein complex which is typical naturally presented component of wheat, barley and rye. Flour from this sources with natural gluten content is also added into the some type of meat products and other foodstuffs for a technological reasons hand in hand with economic reasons.  Some of the gluten quantities could be hazardous for sensitive people as celiatics and allergic to gluten. Within the context of this reasons there is a need to control the amounts of this hidden type of gluten inclusive of spice mixes using in a meat production. Monitoring by itself was realized with a use of the sandwich ELISA RIDASCREEN® Fast Gliadin test. ELISA means enzyme linked immunosorbent assay. It is based on a specific reaction among the enzyme and antigen leading to a creation of a complex.  This test provides us exact quantitification of a gluten content in this type of food products using a colorimetric reaction of a complex by observing of all fundamentals of this technique. There were analysed 16 meat products and 5 types of spice mixes in total.doi:10.5219/167

  17. Ophthalmic Start-Up Chief Executive Officers' Perceptions of Development Hurdles.

    Stewart, William C; Nelson, Lindsay A; Kruft, Bonnie; Stewart, Jeanette A

    2018-01-01

    To identify current challenges facing ophthalmic pharmaceutical start-ups in developing new products. Surveys were distributed to the chief executive officer (CEO) or president of ophthalmic start-ups. The survey attracted 24 responses from 78 surveys distributed (31%). The CEOs stated that a lack of financial capital (n = 18, 75%), FDA regulations (n = 6, 25%), and failure to meet clinical endpoints (n = 6, 25%) were their greatest development hurdles. Risk aversion to medicines in early development (n = 18, 75%), mergers and acquisitions reducing corporate choice for licensing agreements (n = 7, 29%), the emergence of large pharmaceutical-based venture capital funding groups (n = 12, 50%), and the failure of many large pharmaceutical companies to develop their own medicines (n = 10, 42%) were noted as recent prominent trends affecting fundraising. The study suggests that development funding, regulatory burden, and meeting clinical endpoints are the greatest development challenges faced by ophthalmic start-up CEOs. © 2017 S. Karger AG, Basel.

  18. Extension of shelf-life of Chickoo slices using hurdle technology

    Shirodkar, S.; Behere, A.G.; Padwal-Desai, S.R.; Lele, S.S.; Pai, J.S.

    2001-01-01

    An attempt has been made to evolve a protocol to prepare shelf-stable high moisture chickoo slices using Hurdle Technology. The process is based on a slight reduction of water activity (0.98?0.94) by osmosis with a 70 deg Brix sucrose syrup, lowering of pH (5.75 to 4.46) by addition of citric acid, addition of KMS and then subjecting the resulting slices to different doses of gamma radiation ranging from 0.25-1 kGy. Radiation processed chickoo slices remained acceptable for 8 weeks at sub-room temperature (10 ± 2 degC) and for 3 weeks at ambient temperature (28 ± 2 degC) when evaluated by a taste-test panel. (author)

  19. Falls in Swedish hurdle and steeplechase racing and the condition of the track surface

    Gottlieb-Vedi, M.; Pipper, Christian Bressen

    2015-01-01

    Falls in National Hunt races is a tragic part of the sport. The present study focuses on the relation between racing track conditions and the number of falls in Swedish jump racing. The assumption was that more horses fell on heavy or soft going than on good or firm going. Results from all jump...... races at Täby Racecourse (1992-2001) were recorded. Parameters registered were: type and number of races, racing surface and condition, total time to finish the race, number of starting horses and number of falls. In this period 212 races, corresponding to 1,556 horse starts, were registered. Falls were...... registered in 42 races and in total 61 horses fell. The fall frequency on horse level was significantly higher in steeplechases than in hurdle races (odds ratio =3.69; 95% confidence interval (CI) = 1.99-6.85). For the steeplechases recorded in this study, significantly more falls were seen in long distance...

  20. Load training athletes specializing in race to 100 meter hurdles in its annual training cycle

    Radosław Muszkieta

    2016-10-01

    Full Text Available The aim of the study was to provide an annual macrocycle preparation of athletes specializing in the 100 meters hurdles. A detailed discussion of the structure and analyze loads in individual periods of the annual training cycle. And the analysis and discussion of the variables of training athletes Marlene Morton, who allowed her to win the bronze medal Polish Youth Championships in Bialystok. The study was conducted based on a detailed analysis of the training diary kept by the athlete, the coach and the daily interview with the coach conducting Arthur Kohutek. They were presented various training periods and analyzed periods and sub-periods. In the summary they presented the conclusions that can be helpful when planning the burden for athletes who specialize in racing gossip.

  1. Prostate cancer metastasis-driving genes: hurdles and potential approaches in their identification

    Yan Ting Chiang

    2014-08-01

    Full Text Available Metastatic prostate cancer is currently incurable. Metastasis is thought to result from changes in the expression of specific metastasis-driving genes in nonmetastatic prostate cancer tissue, leading to a cascade of activated downstream genes that set the metastatic process in motion. Such genes could potentially serve as effective therapeutic targets for improved management of the disease. They could be identified by comparative analysis of gene expression profiles of patient-derived metastatic and nonmetastatic prostate cancer tissues to pinpoint genes showing altered expression, followed by determining whether silencing of such genes can lead to inhibition of metastatic properties. Various hurdles encountered in this approach are discussed, including (i the need for clinically relevant, nonmetastatic and metastatic prostate cancer tissues such as xenografts of patients' prostate cancers developed via subrenal capsule grafting technology and (ii limitations in the currently available methodology for identification of master regulatory genes.

  2. A novel series of conferences tackling the hurdles confronting the translation of novel cancer immunotherapies

    Bot Adrian

    2012-11-01

    Full Text Available Abstract While there has been significant progress in advancing novel immune therapies to the bedside, much more needs to be done to fully tap into the potential of the immune system. It has become increasingly clear that besides practical and operational challenges, the heterogeneity of cancer and the limited efficacy profile of current immunotherapy platforms are the two main hurdles. Nevertheless, the promising clinical data of several approaches point to a roadmap that carries the promise to significantly advance cancer immunotherapy. A new annual series sponsored by Arrowhead Publishers and Conferences aims at bringing together scientific and business leadership from academia and industry, to identify, share and discuss most current priorities in research and translation of novel immune interventions. This Editorial provides highlights of the first event held earlier this year and outlines the focus of the second meeting to be held in 2013 that will be dedicated to stem cells and immunotherapy.

  3. About ATMPs, SOPs and GMP: The Hurdles to Produce Novel Skin Grafts for Clinical Use.

    Hartmann-Fritsch, Fabienne; Marino, Daniela; Reichmann, Ernst

    2016-09-01

    The treatment of severe full-thickness skin defects represents a significant and common clinical problem worldwide. A bio-engineered autologous skin substitute would significantly reduce the problems observed with today's gold standard. Within 15 years of research, the Tissue Biology Research Unit of the University Children's Hospital Zurich has developed autologous tissue-engineered skin grafts based on collagen type I hydrogels. Those products are considered as advanced therapy medicinal products (ATMPs) and are routinely produced for clinical trials in a clean room facility following the guidelines for good manufacturing practice (GMP). This article focuses on hurdles observed for the translation of ATMPs from research into the GMP environment and clinical application. Personalized medicine in the field of rare diseases has great potential. However, ATMPs are mainly developed and promoted by academia, hospitals, and small companies, which face many obstacles such as high financial burdens.

  4. World as The Biggest Clasroom. Travel as The Best Lesson. Independent Scientific School Expeditions.

    Oleksik, Ireneusz; Lorek, Grzegorz; Dacy-Ignatiuk, Katarzyna

    2013-04-01

    We are a group of teachers from Poland who think that classroom lessons are not enough for our pupils to understand the world. We had a dream to take our students and show them the most beautiful places and phenomena on the Earth. But how to do it? Though today's travelling is so easy as never before, there are still some problems for young Poles - not only funding but also philosophy of travelling. It looks that we found a solution a few years ago - why not to organise quite independent school scientific expeditions? Without travel agencies and agents we can reduce costs of travelling 2-3 times! And we did it! We buy cheap flight tickets, fly to our destination and then... we must manage with all problems ourselves. We sleep in tents or budget hostels, use local means of transport and eat food from cheap markets or street eating places. Our motto is: "To see as much as possible for the minimum money". There are many more advantages - we decide where to go and how much time we spend in one area, we can change our route in every moment if something appears worth seeing. Our small groups are very mobile, sometimes local people invite us to visit their houses (like in Iran or Morocco). Expeditions allow students to watch, feel, touch, taste and smell phenomena, places and organisms which they could only read about in a classroom and to understand people from other cultures and religions. The list of nature and culture jewels that we have already seen is still growing - sands and oasis of Sahara, snow peaks of Himalayas, salt waters of Caspian Sea in Iran, geysers, volcanoes and glaciers of Iceland, the biggest sea birds colonies and whales in the North Atlantic, ancient cities - Fez, Marrakesh, Esfahan, Varanasi and Yazd.

  5. Jupiter's Spot Seen Glowing - Scientists Get First Look at Weather Inside the Solar System's Biggest Storm

    2010-03-01

    New ground-breaking thermal images obtained with ESO's Very Large Telescope and other powerful ground-based telescopes show swirls of warmer air and cooler regions never seen before within Jupiter's Great Red Spot, enabling scientists to make the first detailed interior weather map of the giant storm system linking its temperature, winds, pressure and composition with its colour. "This is our first detailed look inside the biggest storm of the Solar System," says Glenn Orton, who led the team of astronomers that made the study. "We once thought the Great Red Spot was a plain old oval without much structure, but these new results show that it is, in fact, extremely complicated." The observations reveal that the reddest colour of the Great Red Spot corresponds to a warm core within the otherwise cold storm system, and images show dark lanes at the edge of the storm where gases are descending into the deeper regions of the planet. The observations, detailed in a paper appearing in the journal Icarus, give scientists a sense of the circulation patterns within the solar system's best-known storm system. Sky gazers have been observing the Great Red Spot in one form or another for hundreds of years, with continuous observations of its current shape dating back to the 19th century. The spot, which is a cold region averaging about -160 degrees Celsius, is so wide that about three Earths could fit inside its boundaries. The thermal images were mostly obtained with the VISIR [1] instrument attached to ESO's Very Large Telescope in Chile, with additional data coming from the Gemini South telescope in Chile and the National Astronomical Observatory of Japan's Subaru Telescope in Hawaii. The images have provided an unprecedented level of resolution and extended the coverage provided by NASA's Galileo spacecraft in the late 1990s. Together with observations of the deep cloud structure by the 3-metre NASA Infrared Telescope Facility in Hawaii, the level of thermal detail observed

  6. Hurdle technology applied to prickly pear beverages for inhibiting Saccharomyces cerevisiae and Escherichia coli.

    García-García, R; Escobedo-Avellaneda, Z; Tejada-Ortigoza, V; Martín-Belloso, O; Valdez-Fragoso, A; Welti-Chanes, J

    2015-06-01

    The effect of pH reduction (from 6·30-6·45 to 4·22-4·46) and the addition of antimicrobial compounds (sodium benzoate and potassium sorbate) on the inhibition of Saccharomyces cerevisiae and Escherichia coli in prickly pear beverages formulated with the pulp and peel of Villanueva (V, Opuntia albicarpa) and Rojo Vigor (RV, Opuntia ficus-indica) varieties during 14 days of storage at 25°C, was evaluated. RV variety presented the highest microbial inhibition. By combining pH reduction and preservatives, reductions of 6·2-log10 and 2·3-log10 for E. coli and S. cerevisiae were achieved respectively. Due to the low reduction of S. cerevisiae, pulsed electric fields (PEF) (11-15 μs/25-50 Hz/27-36 kV cm(-1)) was applied as another preservation factor. The combination of preservatives, pH reduction and PEF at 13-15 μs/25-50 Hz for V variety, and 11 μs/50 Hz, 13-15 μs/25-50 Hz for RV, had a synergistic effect on S. cerevisiae inhibition, achieving at least 3·4-log10 of microbial reduction immediately after processing, and more than 5-log10 at fourth day of storage at 25°C maintained this reduction during 21 days of storage (P > 0·05). Hurdle technology using PEF in combination with other factors is adequate to maintain stable prickly pear beverages during 21 days/25°C. Significance and impact of the study: Prickly pear is a fruit with functional value, with high content of nutraceuticals and antioxidant activity. Functional beverages formulated with the pulp and peel of this fruit represent an alternative for its consumption. Escherichia coli and Saccharomyces cerevisiae are micro-organisms that typically affect fruit beverage quality and safety. The food industry is looking for processing technologies that maintain quality without compromising safety. Hurdle technology, including pulsed electric fields (PEF) could be an option to achieve this. The combination of PEF, pH reduction and preservatives is an alternative to obtain safe and minimally processed

  7. Effects of gamma irradiation and silver nano particles on microbiological characteristics of saffron, using hurdle technology.

    Hamid Sales, E; Motamedi Sedeh, F; Rajabifar, S

    2012-03-01

    Saffron, a plant from the Iridaceae family, is the world's most expensive spice. Gamma irradiation and silver nano particles whose uses are gradually increasing worldwide, have positive effects on preventing decay by sterilizing the microorganisms and by improving the safety without compromising the nutritional properties and sensory quality of the foods. In the present study combination effects of gamma irradiation and silver nano particles packaging on the microbial contamination of saffron were considered during storage. A combination of hurdles can ensure stability and microbial safety of foods. For this purpose, saffron samples were packaged by Poly Ethylene films that posses up to 300 ppm nano silver particles as antimicrobial agents and then irradiated in cobalt-60 irradiator (gamma cell PX30, dose rate 0.55 Gry/Sec) to 0, 1, 2,3 and 4 kGy at room temperature. The antimicrobial activities against Total Aerobic Mesophilic Bacteria, Entrobacteriace, Escherichia Coli and Clostridium Perfringines were higher in the irradiated samples, demonstrating the inhibition zone for their growth. Irradiation of the saffron samples packaged by Poly Ethylene films with nano silver particles showed the best results for decreasing microbial contamination at 2 kGy and for Poly Ethylene films without silver nano particles; it was 4 kGy.

  8. Property rating potentials and hurdles: what can be done to boost property rating in Ghana?

    Elias Danyi Kuusaana

    2015-06-01

    Full Text Available Population growth in many of Africa’s towns and cities has outpaced local authority capacity to provide efficient management, infrastructure and financing. There is already debate over the capability and capacity of urban local governments to provide basic services to a growing population, due to budget constraints and inability to raise the required local-level revenue. This paper looks at how the potential of property rating can be harnessed to generate the bulk of revenue needed for local-level development, despite the huge default rates across Ghana. Focusing on Wa Municipality as a case study, the study finds that the major hurdles to property rating are poor property data systems, political interference, non-enforcement of the law, low budget deficit in financing revaluation, insufficient staffing, and insufficient technical capacity of the few staff available at the municipal valuation and rating divisions. Despite these constraints, however, field data still indicates that property rating in Ghana, and especially in Wa Municipality, can generate up to 30% of local government revenue needed. This is conditional on streamlining current challenges and improving resources for the rating and valuation units. There is extensive non-payment of property rates in Wa Municipality due to lack of awareness of the purpose of this tax, of how to pay and of the penalties for defaulting payees.

  9. Semantic Web for Chemical Genomics – need, how to, and hurdles

    Talapady Bhat

    2007-08-01

    Full Text Available Semantic Web has been often suggested as the information technology solution to the growing problem in managing the millions of data points generated by modern science such as nanotechnology and high through-put screening for drugs. However, the progress towards this vision envisaged by the W3C has been very limited. Here we discuss –some of the obstacles to the realization of this vision and we make some suggestions as to how one may overcome some of these hurdles? Here we discuss some of these issues and present thoughts on an alternative method to Semantic Web that is less drastic in requirements. This method does not require the use of RDF and Protege, and it works in an environment currently used by the chemical and biological database providers. In our method one attempts to use as many components as possible from the tools already used by the database providers and one brings in far fewer new tools and techniques compared to the method that use RDF or Protégé. Our method uses a standard database environment and web tools rather than the RDF and Protégé to manage user interface and the data is held in a database rather than using RDF. This method shifts the task of building Semantic knowledge-base and ontology from RDF and Protégé to a SQL based database environment.

  10. How to overcome hurdles in opiate substitution treatment? A qualitative study with general practitioners in Belgium.

    Fraeyman, Jessica; Symons, Linda; Van Royen, Paul; Van Hal, Guido; Peremans, Lieve

    2016-06-01

    Opiate substitution treatment (OST) is the administration of opioids (methadone or buprenorphine) under medical supervision for opiate addiction. Several studies indicate a large unmet need for OST in general practice in Antwerp, Belgium. Some hurdles remain before GPs engage in OST prescribing. Formulate recommendations to increase engagement of GPs in OST, applicable to Belgium and beyond. In 2009, an exploratory qualitative research was performed using focus group discussions and interviews with GPs. During data collection and analysis, purposive sampling, open and axial coding was applied. The script was composed around the advantages, disadvantages and conditions of engaging in OST in general practice. We conducted six focus groups and two interviews, with GPs experienced in prescribing OST (n = 13), inexperienced GPs (n = 13), and physicians from addiction centres (n = 5). Overall, GPs did not seem very willing to prescribe OST for opiate users. A lack of knowledge about OST and misbehaving patients creates anxiety and makes the GPs reluctant to learn more about OST. The GPs refer to a lack of collaboration with the addiction centres and a need of support (from either addiction centres or experienced GP-colleagues for advice). Important conditions for OST are acceptance of only stable opiate users and more support in emergencies. Increasing GPs' knowledge about OST and improving collaboration with addiction centres are essential to increase the uptake of OST in general practice. Special attention could be paid to the role of more experienced colleagues who can act as advising physicians for inexperienced GPs.

  11. Hurdles overcome in technology transfer for AIET and Positive outcome in Indian patients

    Dedeepiya V

    2012-01-01

    Full Text Available Introduction Cell based immunotherapies have been in practice in Japan for the past two decades with established clinical trials on its efficacy in both solid tumours and hematological malignancies including gastric cancer, ovarian cancer , lung cancer and liver cancer. [1,2,3,4] In India, NCRM has been providing Autologous Immune Enhancement Therapy (AIET using autologous Natural Killer (NK cells and activated T Lymphocytes for Cancer since 2005 following the established protocols practiced by the Biotherapy Institute of Japan. Significant outcome achieved after AIET in advanced pancreatic cancer, Acute Myeloid leukemia (AML in Indian patients have already been reported. [5, 6] Here we report our experience in few more patients and present the hurdles overcome and lessons learned in translating the technology from Japan to India Case Details: Case 1: A 54 year-old female presented with Stage IV recurrent ovarian malignancy in 2010 with a history of previous surgery and chemotherapy for ovarian malignancy in June 2009. The CA-125 level of 243 U/ml. CT scan revealed lesions in the liver, spleen, along the greater curvature of body of stomach and in the perisplenic region, between the medial aspect of liver and stomach and in the right inguinal region. She was suggested six cycles of chemotherapy with Doxorubicin (50 mg and Carboplatin (450 mg along with AIET. After proper informed consent, the peripheral blood was withdrawn and the in vitro expansion of the NK cells, activated T Lymphocytes from the peripheral blood was performed using the protocol reported earlier. [7] Average cell count after the in vitro expansion was 1.2 X 108 cells. Six transfusions of the in vitro expanded NK cells and activated T lymphocytes were administered following which the CA-125 decreased to 4.7 U/mL. CT scan taken in December 2010 showed a regression of the lesions in the spleen and perisplenic peritoneal deposits, stable hepatic lesions and resolution of

  12. Development of shelf stable pork sausages using hurdle technology and their quality at ambient temperature (37±1°C) storage.

    Thomas, R; Anjaneyulu, A S R; Kondaiah, N

    2008-05-01

    Shelf stable pork sausages were developed using hurdle technology and their quality was evaluated during ambient temperature (37±1°C) storage. Hurdles incorporated were low pH, low water activity, vacuum packaging and post package reheating. Dipping in potassium sorbate solution prior to vacuum packaging was also studied. Reheating increased the pH of the sausages by 0.17units as against 0.11units in controls. Incorporation of hurdles significantly decreased emulsion stability, cooking yield, moisture and fat percent, yellowness and hardness, while increasing the protein percent and redness. Hurdle treatment reduced quality deterioration during storage as indicated by pH, TBARS and tyrosine values. About 1 log reduction in total plate count was observed with the different hurdles as were reductions in the coliform, anaerobic, lactobacilli and Staphylococcus aureus counts. pH, a(w) and reheating hurdles inhibited yeast and mold growth up to day 3, while additional dipping in 1% potassium sorbate solution inhibited their growth throughout the 9 days storage. Despite low initial sensory appeal, the hurdle treated sausages had an overall acceptability in the range 'very good' to 'good' up to day 6.

  13. CRISPR-Cas9 for in vivo Gene Therapy: Promise and Hurdles

    Wei-Jing Dai

    2016-01-01

    Full Text Available Owing to its easy-to-use and multiplexing nature, the genome editing tool CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats (CRISPR associated nuclease 9 is revolutionizing many areas of medical research and one of the most amazing areas is its gene therapy potentials. Previous explorations into the therapeutic potentials of CRISPR-Cas9 were mainly conducted in vitro or in animal germlines, the translatability of which, however, is either limited (to tissues with adult stem cells amenable to culture and manipulation or currently impermissible (due to ethic concerns. Recently, important progresses have been made on this regard. Several studies have demonstrated the ability of CRISPR-Cas9 for in vivo gene therapy in adult rodent models of human genetic diseases delivered by methods that are potentially translatable to human use. Although these recent advances represent a significant step forward to the eventual application of CRISPR-Cas9 to the clinic, there are still many hurdles to overcome, such as the off-target effects of CRISPR-Cas9, efficacy of homology-directed repair, fitness of edited cells, immunogenicity of therapeutic CRISPR-Cas9 components, as well as efficiency, specificity, and translatability of in vivo delivery methods. In this article, we introduce the mechanisms and merits of CRISPR-Cas9 in genome editing, briefly retrospect the applications of CRISPR-Cas9 in gene therapy explorations and highlight recent advances, later we discuss in detail the challenges lying ahead in the way of its translatability, propose possible solutions, and future research directions.

  14. Evaluating components of dental care utilization among adults with diabetes and matched controls via hurdle models

    Chaudhari Monica

    2012-07-01

    Full Text Available Abstract Background About one-third of adults with diabetes have severe oral complications. However, limited previous research has investigated dental care utilization associated with diabetes. This project had two purposes: to develop a methodology to estimate dental care utilization using claims data and to use this methodology to compare utilization of dental care between adults with and without diabetes. Methods Data included secondary enrollment and demographic data from Washington Dental Service (WDS and Group Health Cooperative (GH, clinical data from GH, and dental-utilization data from WDS claims during 2002–2006. Dental and medical records from WDS and GH were linked for enrolees continuously and dually insured during the study. We employed hurdle models in a quasi-experimental setting to assess differences between adults with and without diabetes in 5-year cumulative utilization of dental services. Propensity score matching adjusted for differences in baseline covariates between the two groups. Results We found that adults with diabetes had lower odds of visiting a dentist (OR = 0.74, p  0.001. Among those with a dental visit, diabetes patients had lower odds of receiving prophylaxes (OR = 0.77, fillings (OR = 0.80 and crowns (OR = 0.84 (p 0.005 for all and higher odds of receiving periodontal maintenance (OR = 1.24, non-surgical periodontal procedures (OR = 1.30, extractions (OR = 1.38 and removable prosthetics (OR = 1.36 (p  Conclusions Patients with diabetes are less likely to use dental services. Those who do are less likely to use preventive care and more likely to receive periodontal care and tooth-extractions. Future research should address the possible effectiveness of additional prevention in reducing subsequent severe oral disease in patients with diabetes.

  15. Identifying economic hurdles to early adoption of preventative practices: The case of trunk diseases in California winegrape vineyards

    Jonathan Kaplan

    2016-12-01

    Full Text Available Despite the high likelihood of infection and substantial yield losses from trunk diseases, many California practitioners wait to adopt field-tested, preventative practices (delayed pruning, double pruning, and application of pruning-wound protectants until after disease symptoms appear in the vineyard at around 10 years old. We evaluate net benefits from adoption of these practices before symptoms appear in young Cabernet Sauvignon vineyards and after they become apparent in mature vineyards to identify economic hurdles to early adoption. We simulate winegrape production in select counties of California and find widespread benefits from early adoption, increasing vineyard profitable lifespans, in some cases, by close to 50%. However, hurdles may result from uncertainty about the cost and returns from adoption, labor constraints, long time lags in benefits from early adoption, growers’ perceived probabilities of infection, and their discount rate. Development of extension resources communicating benefits and potential hurdles to growers likely reduces uncertainty, increasing early adoption. Improvements in efficacy of preventative practices, perhaps by detecting when pathogen spores are released into the vineyard, will increase early adoption. Lastly, practice cost reductions will increase early adoption too, especially when the time it takes for adoption to payoff and infection uncertainty are influential in adoption decisions.

  16. Four hurdles for conservation on private land: the case of the golden lion tamarin, Atlantic Forest, Brazil.

    Ralf Christopher Buckley

    2015-08-01

    Full Text Available Many threatened species worldwide rely on patches of remnant vegetation in private landholdings. To establish private reserves that contribute effectively to conservation involves a wide range of complex and interacting ecological, legal, social and financial factors. These can be seen as a series of successive hurdles, each with multiple bars, which must all be surmounted. The golden lion tamarin, Leontopithecus rosalia, is restricted to the Atlantic Forest biome in the state of Rio de Janeiro, Brazil. This forest is largely cleared. There are many small remnant patches on private lands, able to support tamarins. Local NGO’s have successfully used limited funds to contribute to tamarin conservation in a highly cost effective way. We examined the mechanisms by analysing documents and interviewing landholders and other stakeholders. We found that the local NGOs successfully identified landholdings where ecological, legal, social and some financial hurdles had already been crossed, and helped landholders over the final financial hurdle by funding critical cost components. This cost <5% of the price of outright land purchase. This approach is scaleable for golden lion tamarin elsewhere within the Atlantic Forest biome, and applicable for other species and ecosystems worldwide.

  17. Mechanisms of adaptation to intensive loads of 400 meters’ hurdles runners at stage of initial basic training

    A.S. Rovniy

    2015-08-01

    Full Text Available Purpose: is study of adaptation mechanisms of 400 meter’ hurdles-runners to intensive physical loads. Material: in the research 13 - 400 meters’ hurdles-runners and 13 - 400 meters’ runners participated. Results: it was found that physiological cost of sportsmen’s special workability has fragmentary character. We presented results of physiological and bio-chemical adaptation mechanisms to dozed work. The received results have no confident distinctions and can not objectively characterize mechanisms of sportsmen’s special workability. We did not detect definite differences in indicators of mechanisms, ensuring sportsmen’s special workability under dozed loads. We found, that level of anaerobic glycolysis is an objective criterion of 400 meter’ hurdles-runners’ special workability. It was shown that for determination of functional potentials for such kind of functioning it is necessary to apply special loads. Conclusions: the received results deepen information about mechanisms of adaptation to specific competition functioning. Correct approaches to processing and analysis of the research’s results permit to more specifically determine sportsmen’s functional potentials in different kinds of competition functioning.

  18. Descemet's membrane endothelial keratoplasty surgery: update on the evidence and hurdles to acceptance.

    Price, Marianne O; Price, Francis W

    2013-07-01

    Descemet's stripping endothelial keratoplasty (DSEK) is the most popular treatment for endothelial dysfunction, but Descemet's membrane endothelial keratoplasty (DMEK) now provides better vision with lower risk of immunologic rejection. Although DMEK is more challenging, advances in instrumentation and techniques are reducing the learning curve. In contrast to DSEK, which includes posterior donor stroma, DMEK consists merely of donor endothelium and Descemet's membrane, so DMEK does not create a stromal interface and induces significantly less posterior surface aberrations, resulting in better vision. Furthermore, multiple centers report remarkably low (<1%) cumulative probability of immunologic graft rejection episodes through 2 years after DMEK. Initially, the biggest challenges were tissue loss in preparation and ensuring attachment. Subsequent improvements have reduced complication rates to levels experienced with DSEK. DMEK/DSEK hybrids and 'thin' DSEK also can provide better vision than standard DSEK; randomized controlled comparisons with DMEK are needed. DMEK provides an anatomically exact replacement of dysfunctional host endothelium and has set new benchmarks for rejection risk and visual outcomes following endothelial replacement. DMEK is providing new insights into how different corneal layers contribute to immunogenicity and immune tolerance and into the key factors that limit vision after endothelial keratoplasty.

  19. Successful cleaning concept for Germany's biggest reverse osmosis plant; Ein erfolgreiches Reinigungskonzept fuer die groesste Umkehrosmoseanlage Deutschlands

    Kempen, Hermann [Kurita Europe GmbH, Viersen (Germany); Zierau, Ronald [Zellstoff-Stendal GmbH, Arneburg (Germany)

    2012-07-01

    During the last years, new developments for membrane material and also for treatment chemicals have resulted in higher efficiency and reliability of reverse osmosis (RO) plants. Nevertheless, especially RO plants receiving raw water from surface waters with open intake or from waste water streams are facing problems with fouling on membranes during operation. In such cases, the efficient cleaning of membranes is mandatory to ensure long-term supply of permeate in high quality and sufficient quantity. New cleaning concepts with proprietary cleaning products are gaining in importance. The successful application of such a cleaning concept at Germany's biggest RO plant is described in this paper. (orig.)

  20. This will the world what will be the biggest experiment in ... and we don't really know happen when we turn it on!

    Leighton, Barry

    2007-01-01

    Jim Brooke gazed admiringly at the 12'500 tonne time machine which is slowly taking shape in an eerie subterranean vault and declared: "This is the biggest physics experiment ever and will be for years to come. (2pages)

  1. A Record Holder Female Athlete’s Train ing Loads and its Distribution in Women 400 meter Hurdle Running

    Sibel DÜNDAR

    2015-07-01

    Full Text Available The purpose of this study was to investigate the effects on 400 mt characteristics of women training load used in the hurdle runnig , the distribution and performance according to the period. At this study female athlete’s, who won second place at the European Champion Clubs' Cup Competitions and had a record - breaking six times in a country, five - year training loads and degrees were investigated. In this study, athlete’s degrees an d training loads were analyzed between the years of 1982 - 1987. Atlete’s best 100m,200m,400m,400m hurdle degrees and some training loads (sprint, andurance, weight lifting were assessed by the means and satandart deviations. Athlete’s sprint and training l oads mean and standard deviation values were calculated as 100 m ( 11.96 ± 0.17 , 200m ( 25.0 ± 0.38 , 400m ( 56.07 ± 0.91 and 400 m hurdle running ( 60.38 ± 1.88 and for the training loads of 0 - 150 m sprint ( 66.85 ± 18.95 m, endurance ( 2 02.55 ± 57.56 miles and weightlifting( 151.88 ± 68.2 tons. It was observed that percentage of change of the value of training loads and the running performance changes were not increase at the same rate. Regarding the relationship between the best run ning degree and training load, it was found a significant relationship between only 60 m sprint and 150 - 450 m sprint degrees.

  2. What are the biggest obstacles to growth of SMEs in developing countries? – An empirical evidence from an enterprise survey

    Yao Wang

    2016-09-01

    Full Text Available SMEs are drivers of economic growth and job creation in developing countries. It is paramount to determine the factors that hinder their growth. This paper uses the Enterprise Survey from the World Bank which covers data from 119 developing countries to investigate the biggest obstacles SMEs are confronting and the determinants that influence the obstacles as perceived by enterprise managers. The results show that SMEs perceive access to finance as the most significant obstacle which hinders their growth. The key determinants among firms' characteristics are size, age and growth rate of firms as well as the ownership of the firm. The latter – the role of the state in financing SME – is particularly intriguing. External reasons for the financing dilemma are also examined. It is shown that the main barriers to external financing are high costs of borrowing and a lack of consultant support.

  3. Why have China and Russia become Uzbekistan’s biggest energy partners? Exploring the role of exogenous and endogenous factors

    Oybek Madiyev

    2017-03-01

    Full Text Available In the 1990s, there was an expectation that Uzbekistan, along with other countries in Central Asia, would gradually move towards the West by distancing itself from the sphere of Russian influence. However, in spite of the West’s significant investment in the region’s economies and attempts to enter the local markets through both bilateral and multilateral channels, this shift never materialised. In fact, since the collapse of the Union of Soviet Socialist Republics (USSR, Uzbekistan’s trade cooperation with Russia has remained robust, and only in 2014 did China overtook Russia as Uzbekistan’s biggest trading partner. This article aims to understand why Russia and China have become Uzbekistan’s biggest economic partners, especially in the energy sector. To understand this, I believe that it is important to analyse the nature of both domestic and international factors and their interaction. First of all, there are international factors: globalisation, the rise of China and an increase in global demand for natural resources; the role of the China-initiated the Shanghai Cooperation Organisation and the Silk Road Economic Belt; and Russia’s attempt to reclaim its “great power” status since 2000 and Putin’s attempt to build and expand the Eurasian Economic Union. Second, there are domestic factors: understanding Russia’s and China’s foreign trade policy linked not only with economic growth but also with the structure of foreign economic policy decision-making, or “power vertical,” among other domestic elements. This article will draw on Critical International Political Economy (CIPE to argue that this tradition is well equipped and offers an important framework to understand foreign economic policy of powers such as Russia and China. The CIPE does not simply combine the domestic and international factors but also insists on their indivisibility and engages with cultural, ideological and social elements in their historical

  4. Cost-offsets of prescription drug expenditures: data analysis via a copula-based bivariate dynamic hurdle model.

    Deb, Partha; Trivedi, Pravin K; Zimmer, David M

    2014-10-01

    In this paper, we estimate a copula-based bivariate dynamic hurdle model of prescription drug and nondrug expenditures to test the cost-offset hypothesis, which posits that increased expenditures on prescription drugs are offset by reductions in other nondrug expenditures. We apply the proposed methodology to data from the Medical Expenditure Panel Survey, which have the following features: (i) the observed bivariate outcomes are a mixture of zeros and continuously measured positives; (ii) both the zero and positive outcomes show state dependence and inter-temporal interdependence; and (iii) the zeros and the positives display contemporaneous association. The point mass at zero is accommodated using a hurdle or a two-part approach. The copula-based approach to generating joint distributions is appealing because the contemporaneous association involves asymmetric dependence. The paper studies samples categorized by four health conditions: arthritis, diabetes, heart disease, and mental illness. There is evidence of greater than dollar-for-dollar cost-offsets of expenditures on prescribed drugs for relatively low levels of spending on drugs and less than dollar-for-dollar cost-offsets at higher levels of drug expenditures. Copyright © 2013 John Wiley & Sons, Ltd.

  5. Clearing up the hazy road from bench to bedside: A framework for integrating the fourth hurdle into translational medicine

    John Jürgen H

    2008-09-01

    Full Text Available Abstract Background New products evolving from research and development can only be translated to medical practice on a large scale if they are reimbursed by third-party payers. Yet the decision processes regarding reimbursement are highly complex and internationally heterogeneous. This study develops a process-oriented framework for monitoring these so-called fourth hurdle procedures in the context of product development from bench to bedside. The framework is suitable both for new drugs and other medical technologies. Methods The study is based on expert interviews and literature searches, as well as an analysis of 47 websites of coverage decision-makers in England, Germany and the USA. Results Eight key steps for monitoring fourth hurdle procedures from a company perspective were determined: entering the scope of a healthcare payer; trigger of decision process; assessment; appraisal; setting level of reimbursement; establishing rules for service provision; formal and informal participation; and publication of the decision and supplementary information. Details are given for the English National Institute for Health and Clinical Excellence, the German Federal Joint Committee, Medicare's National and Local Coverage Determinations, and for Blue Cross Blue Shield companies. Conclusion Coverage determination decisions for new procedures tend to be less formalized than for novel drugs. The analysis of coverage procedures and requirements shows that the proof of patient benefit is essential. Cost-effectiveness is likely to gain importance in future.

  6. Planning Training Loads for the 400 M Hurdles in Three-Month Mesocycles using Artificial Neural Networks.

    Przednowek, Krzysztof; Iskra, Janusz; Wiktorowicz, Krzysztof; Krzeszowski, Tomasz; Maszczyk, Adam

    2017-12-01

    This paper presents a novel approach to planning training loads in hurdling using artificial neural networks. The neural models performed the task of generating loads for athletes' training for the 400 meters hurdles. All the models were calculated based on the training data of 21 Polish National Team hurdlers, aged 22.25 ± 1.96, competing between 1989 and 2012. The analysis included 144 training plans that represented different stages in the annual training cycle. The main contribution of this paper is to develop neural models for planning training loads for the entire career of a typical hurdler. In the models, 29 variables were used, where four characterized the runner and 25 described the training process. Two artificial neural networks were used: a multi-layer perceptron and a network with radial basis functions. To assess the quality of the models, the leave-one-out cross-validation method was used in which the Normalized Root Mean Squared Error was calculated. The analysis shows that the method generating the smallest error was the radial basis function network with nine neurons in the hidden layer. Most of the calculated training loads demonstrated a non-linear relationship across the entire competitive period. The resulting model can be used as a tool to assist a coach in planning training loads during a selected training period.

  7. Planning Training Loads for The 400 M Hurdles in Three-Month Mesocycles Using Artificial Neural Networks

    Przednowek Krzysztof

    2017-12-01

    Full Text Available This paper presents a novel approach to planning training loads in hurdling using artificial neural networks. The neural models performed the task of generating loads for athletes’ training for the 400 meters hurdles. All the models were calculated based on the training data of 21 Polish National Team hurdlers, aged 22.25 ± 1.96, competing between 1989 and 2012. The analysis included 144 training plans that represented different stages in the annual training cycle. The main contribution of this paper is to develop neural models for planning training loads for the entire career of a typical hurdler. In the models, 29 variables were used, where four characterized the runner and 25 described the training process. Two artificial neural networks were used: a multi-layer perceptron and a network with radial basis functions. To assess the quality of the models, the leave-one-out cross-validation method was used in which the Normalized Root Mean Squared Error was calculated. The analysis shows that the method generating the smallest error was the radial basis function network with nine neurons in the hidden layer. Most of the calculated training loads demonstrated a non-linear relationship across the entire competitive period. The resulting model can be used as a tool to assist a coach in planning training loads during a selected training period.

  8. Biggest semiconductor installed

    2008-01-01

    Scientists and technicians at the European Laboratory for Particle Physics, commonly known by its French acronym CERN (Centre Europen pour la Recherche Nuclaire), have completed the installation of the largest semiconductor silicon detector.

  9. Our biggest challenge.

    Mcfadden, P; Ray, S

    1994-06-01

    An AIDS activist in Zimbabwe answered questions about the nature of the current AIDS campaign, the way of handling sexuality issues, the impact on men of women's discourse about AIDS, outreach strategies, the accuracy of information, women's status and the difficulties of women responding to the AIDS crisis. The Women and AIDS Support Network (WASN) was organized in 1989 with the aim of informing women about AIDS transmission and prevention. Information was transmitted through other organizations, because there was the lack of facility and resources to develop a grassroots effort. The request was that any meeting on women's health, development, or other issues discuss AIDS. One problem was how to teach women to overcome the obstacles to asking their husbands to use safer sex. Couples generally did not discuss sexual issues, and attempts to discuss condom use with husbands were met by the husbands' anger that their sexual behavior has been exposed at women's meetings. The concern was raised that when men feel a loss of control, violence against women is possible. A university team has been put together to work on sexuality education at schools and within the university. WASN women have found that an important source of information transmission is from mothers to daughters in an understanding, rather than a punitive, way. WASN has worked hard to show women working together instead of blaming each other. Men have actively sought to separate women from each other. WASN women desire to keep the family intact without having to sacrifice themselves in the process by accepting a subservient position to men and not having decision-making power. There is a myth that men are heads of households. Most women are running their own families and even towns, because men have chosen not to be there or because of commitments to more than one family. African women are valued so strongly for their reproductive capacity that it would almost impossible to instill in women the notion of womanhood without children. Women do not believe they have child-bearing choices. Differential AIDS mortality for women will decrease the young female population, which will increase pressure on women to bear children. The greatest challenge is to make women feel valued and believe in themselves.

  10. PREDICTIVE CONTRIBUTION OF MORPHOLOGICAL CHARACTERISTICS AND MOTOR ABILITIES ON THE RESULT OF RUNNING THE 60m HURDLES IN BOYS AGED 12 - 13 YEARS

    Zana Bujak

    2014-06-01

    Full Text Available The subject of this study is to determine predictive contributions of morphological characteristics and motor abilities on the 60m hurdles, with an aim to form a group of easily applicable field tests so as to identify boys who are talented in hurdl e racing . The subject sample of this study was comprised of 60 boys aged 12 - 13. The variable sample consisted of a 60m hurdles criterion variable and a set of 13 p re dictor variables comprising of morphological characteristics, speed - strength abilities and the subjects' coordina tion qualities . Applying the regression analysis , the predictive contribution of a complete variable s et of morpholog ical characteristics and motor abilities was determined as an above average statistical significance, influencing 60m hurdle outcome. The greatest individual statistically significant predictive contribution was achieved by the variables of speed - strength quality assessment: 20m flying start r ace result with a standing long jump; and only one variable from the field of morphological characteristics: the shin length. The results support the following conclusion: the two specific variables of speed - strength quality, and 20m flying start race results along with standing long jump , can be relevant predictors of successful outcome in hurdle races .

  11. Marginalized multilevel hurdle and zero-inflated models for overdispersed and correlated count data with excess zeros.

    Kassahun, Wondwosen; Neyens, Thomas; Molenberghs, Geert; Faes, Christel; Verbeke, Geert

    2014-11-10

    Count data are collected repeatedly over time in many applications, such as biology, epidemiology, and public health. Such data are often characterized by the following three features. First, correlation due to the repeated measures is usually accounted for using subject-specific random effects, which are assumed to be normally distributed. Second, the sample variance may exceed the mean, and hence, the theoretical mean-variance relationship is violated, leading to overdispersion. This is usually allowed for based on a hierarchical approach, combining a Poisson model with gamma distributed random effects. Third, an excess of zeros beyond what standard count distributions can predict is often handled by either the hurdle or the zero-inflated model. A zero-inflated model assumes two processes as sources of zeros and combines a count distribution with a discrete point mass as a mixture, while the hurdle model separately handles zero observations and positive counts, where then a truncated-at-zero count distribution is used for the non-zero state. In practice, however, all these three features can appear simultaneously. Hence, a modeling framework that incorporates all three is necessary, and this presents challenges for the data analysis. Such models, when conditionally specified, will naturally have a subject-specific interpretation. However, adopting their purposefully modified marginalized versions leads to a direct marginal or population-averaged interpretation for parameter estimates of covariate effects, which is the primary interest in many applications. In this paper, we present a marginalized hurdle model and a marginalized zero-inflated model for correlated and overdispersed count data with excess zero observations and then illustrate these further with two case studies. The first dataset focuses on the Anopheles mosquito density around a hydroelectric dam, while adolescents' involvement in work, to earn money and support their families or themselves, is

  12. Development of the monitoring technique on the damage of piles using the biggest shaking table "E-defense"

    Hayashi, Kazuhiro; Hachimori, Wataru; Kaneda, Shogo; Tamura, Shuji; Saito, Taiki

    2017-10-01

    In case of earthquake damage to buildings, the damage to a superstructure is visible, but the damage to a foundation structure, e.g. the underground pile, is difficult to detect. In this study, the authors aim to develop a monitoring technique for pile damage due to earthquakes. The world's biggest shaking table, E-Defense, was used to reproduce damage to RC pile models embedded in the soil inside a large scale shear box (8m in diameter and 6.5m in height). The diameter of the RC pile model was 154mm. It consisted of mortar (27.2N/mm2 in compressive strength), 6 main reinforcements (6.35mm in diameter) and shear reinforcement hard steel wire (2mm in diameter at intervals of 20mm). The natural period of the superstructure above the pile models is around 0.12sec. The soil consisted of 2 layers. The lower layer is Albany sand of 80% relative density while the upper layer is only 2m from the surface ground and is Kaketsu sand of 60% relative density. Primary four excitations were scaled from JMA Kobe waves in notification at different amplitudes. The maximum acceleration of each wave is 31gal, 67gal, 304gal, and 458gal, respectively. In the test result, reinforcing steels at the pile head of the RC model yielded when the maximum acceleration was 304gal. After that, mortar of the pile head peeled off and a bending shear failure occurred when the maximum acceleration was 458gal. The peak frequency of rotational spectrum on the foundation did not change in elastic range in the piles. However, the peak frequency fell after the plastic hinge occurred.

  13. Hurdles in tissue engineering/regenerative medicine product commercialization: a pilot survey of governmental funding agencies and the financial industry.

    Bertram, Timothy A; Tentoff, Edward; Johnson, Peter C; Tawil, Bill; Van Dyke, Mark; Hellman, Kiki B

    2012-11-01

    The Tissue Engineering and Regenerative Medicine International Society of the Americas (TERMIS-AM) Industry Committee conducted a semiquantitative opinion survey in 2010 to delineate potential hurdles to commercialization perceived by the TERMIS constituency groups that participate in the stream of technology commercialization (academia, start-up companies, development-stage companies, and established companies). A significant hurdle identified consistently by each group was access to capital for advancing potential technologies into development pathways leading to commercialization. A follow-on survey was developed by the TERMIS-AM Industry Committee to evaluate the financial industry's perspectives on investing in regenerative medical technologies. The survey, composed of 15 questions, was developed and provided to 37 investment organizations in one of three sectors (governmental, private, and public investors). The survey was anonymous and confidential with sector designation the only identifying feature of each respondent's organization. Approximately 80% of the survey was composed of respondents from the public (n=14) and private (n=15) sectors. Each respondent represents one investment organization with the potential of multiple participants participating to form the organization's response. The remaining organizations represented governmental agencies (n=8). Results from this survey indicate that a high percentage ($2MM into regenerative medical companies at the different stages of a company's life cycle. Investors recognized major hurdles to this emerging industry, including regulatory pathway, clinical translation, and reimbursement of these new products. Investments in regenerative technologies have been cyclical over the past 10-15 years, but investors recognized a 1-5-year investment period before the exit via Merger and Acquisition (M&A). Investors considered musculoskeletal products and their top technology choice with companies in the clinical stage

  14. High resolution of anthropogenic atmospheric emissions of 12 heavy metals in the three biggest metropolitan areas, China

    Tian, H.; Zhu, C.

    2015-12-01

    Atmospheric emissions of typical toxic heavy metals from anthropogenic sources have received worldwide concerns due to their adverse effects on human health and the ecosystem. An integrated inventory of anthropogenic emissions of twelve HMs (Hg, As, Se, Pb, Cd, Cr, Ni, Sb, Mn, Co, Cu and Zn) in the three biggest metropolitan areas, including Beijing-Tianjin-Hebei (BTH) region, Yangtze River Delta (YRD) region and Pearl River Delta (PRD) region, are developed for 1980-2012 by combining with detailed activity data and inter-annual dynamic emission factors which are determined by S-shaped curves on account of technology progress, economic development, and emission control. The results indicate total emissions of twelve HMs in the three metropolitan regions have increased from 5448.8 tons in 1980 to 19054.9 tons in 2012, with an annual average growth rate of about 4.0%. Due to significant difference in industrial structures and energy consumption compositions, remarkable distinctions can be observed with respect to source contributions of total HM emissions from above three metropolitan areas. Specifically, the ferrous metal smelting sector, coal combustion by industrial boilers and coal combustion by power plants are found to be the primary source of total HM emissions in the BTH region (about 34.2%), YRD region (about 28.2%) and PRD region (about 24.3%), respectively. Furthermore, we allocate the annual emissions of these heavy metals in 2012 at a high spatial resolution of 9 km × 9 km grid with ArcGIS methodology and surrogate indexes, such as regional population and gross domestic product (GDP). The peak of HM emissions are mainly distributed over the grid cells of Beijing, Tianjin, Tangshan, Shijiazhuang, Handan and Baoding in the BTH region; Shanghai, Suzhou, Wuxi, Nanjing, Hangzhou, Ningbo in the YRD region; Guangzhou, Shenzhen, Dongguan, Foshan in the PYD region, respectively. Additionally, monthly emission profiles are established in order to further identify

  15. A Double Hurdle Approach

    2017-05-01

    May 1, 2017 ... show that enterprise size, interest rate, loan duration, level of profit ..... is a dummy taking a value of 1 if enterprise is in trading of agricultural ..... government's role in ensuring a stable macroeconomic environment that favours.

  16. Scaling Solutions to Higher Education's Biggest Challenges: An NMC Horizon Project Strategic Brief. Volume 3.2

    Hall Giesinger, C.; Adams Becker, S.; Davis, A.; Shedd, L.

    2016-01-01

    Higher education is ripe for innovation. While emerging technological developments such as digital courseware and mobiles apps have made it easier than ever for people to engage with learning resources, significant issues of access and equity persist among students from low-income, minority, single-parent families, and other disadvantaged groups.…

  17. Enhancing the lethal effect of high-intensity pulsed electric field in milk by antimicrobial compounds as combined hurdles.

    Sobrino-López, A; Martín-Belloso, O

    2008-05-01

    High-intensity pulsed electric field (HIPEF) is a nonthermal treatment studied for its wide antimicrobial spectrum on liquid food, including milk and dairy products. Moreover, the antimicrobial effect of HIPEF may be enhanced by combining HIPEF with other treatments as hurdles. Nisin and lysozyme are natural antimicrobial compounds that could be used in combination with HIPEF. Therefore, the purpose of this study was to determine the effect of combining HIPEF with the addition of nisin and lysozyme to milk inoculated with Staphylococcus aureus with regard to different process variables. The individual addition of nisin and lysozyme did not produce any reduction in cell population within the proposed range of concentrations, whereas their combination resulted in a pH-dependent microbial death of Staph. aureus. The addition of nisin and lysozyme to milk combined with HIPEF treatment resulted in a synergistic effect. Applying a 1,200-micros HIPEF treatment time to milk at pH 6.8 containing 1 IU/mL of nisin and 300 IU/mL of lysozyme resulted in a reduction of more than 6.2 log units of Staph. aureus. Final counts resulting from the addition of nisin and lysozyme and applying HIPEF strongly depended on both the sequence of application and the milk pH. Thus, more research is needed to elucidate the mode of action of synergism as well as the role of different process variables, although the use of HIPEF in combination with antimicrobial compounds such as nisin and lysozyme is shown to be potentially useful in processing milk and dairy products.

  18. E-ELT Site Chosen - World's Biggest Eye on the Sky to be Located on Armazones, Chile

    2010-04-01

    On 26 April 2010, the ESO Council selected Cerro Armazones as the baseline site for the planned 42-metre European Extremely Large Telescope (E-ELT). Cerro Armazones is a mountain at an altitude of 3060 metres in the central part of Chile's Atacama Desert, some 130 kilometres south of the town of Antofagasta and about 20 kilometres from Cerro Paranal, home of ESO's Very Large Telescope. "This is an important milestone that allows us to finalise the baseline design of this very ambitious project, which will vastly advance astronomical knowledge," says Tim de Zeeuw, ESO's Director General. "I thank the site selection team for the tremendous work they have done over the past few years." ESO's next step is to build a European extremely large optical/infrared telescope (E-ELT) with a primary mirror 42 metres in diameter. The E-ELT will be "the world's biggest eye on the sky" - the only such telescope in the world. ESO is drawing up detailed construction plans together with the community. The E-ELT will address many of the most pressing unsolved questions in astronomy, and may, eventually, revolutionise our perception of the Universe, much as Galileo's telescope did 400 years ago. The final go-ahead for construction is expected at the end of 2010, with the start of operations planned for 2018. The decision on the E-ELT site was taken by the ESO Council, which is the governing body of the Organisation composed of representatives of ESO's fourteen Member States, and is based on an extensive comparative meteorological investigation, which lasted several years. The majority of the data collected during the site selection campaigns will be made public in the course of the year 2010. Various factors needed to be considered in the site selection process. Obviously the "astronomical quality" of the atmosphere, for instance, the number of clear nights, the amount of water vapour, and the "stability" of the atmosphere (also known as seeing) played a crucial role. But other

  19. Using Data Collection Apps and Single-Case Designs to Research Transformative Learning in Adults

    Roessger, Kevin M.; Greenleaf, Arie; Hoggan, Chad

    2017-01-01

    To overcome situational hurdles when researching transformative learning in adults, we outline a research approach using single-case research designs and smartphone data collection apps. This approach allows researchers to better understand learners' current lived experiences and determine the effects of transformative learning interventions on…

  20. Can ratio of the biggest tumor diameter to total tumor diameter be a new parameter in the differential diagnosis of agressive and favorable multifocal papillary thyroid microcarcinoma?

    Tam, Abbas Ali; Özdemir, Didem; Çuhacı, Neslihan; Başer, Hüsniye; Dirikoç, Ahmet; Aydın, Cevdet; Yazgan, Aylin Kılıç; Ersoy, Reyhan; Çakır, Bekir

    2017-02-01

    In this study, we aimed to evaluate the usefulness of a new parameter -ratio of the biggest tumor diameter to total tumor diameter- for the differentiation of agressive and favorable papillary thyroid microcarcinomas (PTMC). The diameter of the biggest tumor focus was taken as the primary tumor diameter. Total tumor diameter was calculated as the sum of the maximal diameter of each lesion. Ratio of primary tumor diameter to total tumor diameter was defined as tumor diameter ratio (TDR). Positive and negative predictive value, sensitivity and specificity of TDR to predict capsular invasion, extrathyroidal extension (ETE) and lymph node metastasis (LNM) were determined. Mean TDR was significantly lower in multifocal PTMC patients with capsular invasion, ETE, lymphovascular invasion and LNM compared to patients without these features. The sensitivities of TDR for the detection of LNM, ETE and capsular invasion were 100%, 100% and 94.2%, respectively. Specificity of TDR was 86.2% for LNM, 88% for ETE and 94.7% for capsular invasion. Best cut off values of TDR that can predict capsular invasion, ETE and LNM in multifocal PTMC were 0.62, 0.57 and 0.56, respectively. Multifocal papillary thyroid carcinoma patients with capsular invasion, ETE and LNM had significantly lower mean TDR when compared to ones without these features. Decreased TDR was associated with capsular invasion, ETE and LNM in patients with multifocal PTMC and PTC. This new parameter might be particularly helpful for the detection of aggressive behavior in multifocal PTMCs. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. Effects of sonication and ultraviolet-C treatment as a hurdle concept on quality attributes of Chokanan mango (Mangifera indica L.) juice.

    Santhirasegaram, Vicknesha; Razali, Zuliana; Somasundram, Chandran

    2015-04-01

    The growing demand for fresh-like food products has encouraged the development of hurdle technology of non-thermal processing. In this study, freshly squeezed Chokanan mango juice was treated by paired combinations of sonication (for 15 and 30 min at 25 ℃, 40 kHz frequency) and UV-C treatment (for 15 and 30 min at 25 ℃). Selected physicochemical properties, antioxidant activities, microbial inactivation and other quality parameters of combined treated juice were compared to conventional thermal treatment (at 90 ℃ for 60 s). After thermal and combined treatment, no significant changes occurred in physicochemical properties. A significant increase in extractability of carotenoids (15%), polyphenols (37%), flavonoids (35%) and enhancement in antioxidant capacity was observed after combined treatment. Thermal and combined treatment exhibited significant reduction in microbial load. Results obtained support the use of sonication and UV-C in a hurdle technology to improve the quality of Chokanan mango juice along with safety standards. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  2. The Relationship between Place of Residence and Hospitalization Rate in the Biggest Referral Hospital of the Northwest according to Hospitalization Wards

    Amin Talebpour

    2016-06-01

    Full Text Available ​ Background and objectives: In accordance with the global pattern, the urban population in Iran is higher than the rural population. But, are the statistics of using hospitalization services in public hospitals in these two categories similar to this pattern? This study seeks to determine the effect of place of residence on hospitalization rate by examining annual hospitalization statistics of the country’s biggest referral hospital in the northwest. Material and Methods: The method used in this study is cross-sectional and all cases of hospitalization in Imam Reza Hospital as the northwest’s biggest referral hospital were picked by available sampling method. The cases of 30260 hospitalized patients were examined through direct observation and items extracted from their files were recorded in the checklist. In order to determine the relations between the variables, K2 test was applied and the P-value was considered less than 0.05 The obtained data were analyzed by SPSS.16 software. Results: Results indicated that the frequency distribution of patients in terms of their urban or rural residence did not yield any significant difference (P>0/05. Results also showed that the highest hospitalization rate for urban patients was 16.1% (3305 individuals in surgery ward while it was 14.2% (1384 individuals for rural patients in orthopedic ward. The least significant statistical difference between urban and rural hospitalization rates was observed in renal ward with 72.9% (1162 individual urban patients and 27.1% (432 individuals rural patients of total patients hospitalized in this ward. The most significant statistical difference between urban and rural hospitalization rates was observed in ICU with 44.9% (297 individuals urban patients and 55.1% (365 individuals rural patients of the total patients hospitalized in this ward. Conclusion: A relative comparison among illnesses in urban and rural populations, aside from illnesses caused by trauma

  3. COVARIANCE STABILITY AND THE 2008 FINANCIAL CRISIS: THE IMPACT IN THE PORTFOLIO OF THE 10 BIGGEST COMPANIES IN BM&FBOVESPA BETWEEN 2004 E 2012

    Leticia Naomi Ono Maeda

    2016-03-01

    Full Text Available This study's purpose is to analyse the covariance between the ten biggest participants of the BM&FBovespa stock market to test the influence of the instability in the covariance between assets to the structure of a portfolio of investments of a portfolio composed by this assets. To acomplish that, we check the covariances between the daily returns of the 10 selected stocks before, during and after the 2008 financial crisis. The procedure of this research includes: (1 collection of returns of the selected stocks between 2004 and 2012; (2 the composition of the classical portfolio theory proposed by Markowitz(1952; and (3 the measurement of the effect of the unstable covariance between the 10 selected assets in the maintenance of the portfolio when controlling for return and risk preferences of a hipotetical investor. We find that asset correlations are impacted by the assets covariances that not stable in the whole time set for the study but are specialy sensitive in the financial crisis period. This means that both risk and return of the portfolio will change greatly if the weights are not recalculated from time to time. This suports the idea that portfolio theory might benefit from the development of stability weigthed techniques are developed.

  4. Struktura makrocyklu treningowego w biegu na 100 m przez płotki = The structure of the training macrocycle in the 100 m hurdles

    Maria Kamrowska-Nowak

    2015-12-01

    UKW w Bydgoszczy, IKF   Streszczenie Celem badań była analiza struktury czasowej oraz charakterystyka obciążeń treningowych płotkarki w rocznym cyklu, zrealizowanych przez zawodniczkę specjalizującą się w biegu na 100 m przez płotki. Materiał badawczy stanowiła dokumentacja szkolenia i obciążeń  treningowych zawodniczki S.G., mistrzyni Polski juniorek z 1999 r. oraz młodzieżowej mistrzyni Polski z 2000 r. Zebrany materiał dotyczący obciążeń treningowych skatalogowano według klasycznego podziału ćwiczeń ze względu na cechy motoryczne. Przygotowania treningowe do cyklu 1999/2000 trwały 336 dni. Zrealizowano 367 jednostek treningowych. W przygotowaniu siłowym największe obciążenie miało charakter ukierunkowany o przewadze półprzysiadów oraz podskoków i wyskoków z półprzysiadu. Siła o charakterze wszechstronnym miała mniejszy wymiar. Największe obciążenie pracą siłową miało miejsce od marca do czerwca. W okresie przygotowania ogólnego (listopad, grudzień, styczeń dominowała wytrzymałość tempowa krótka (odcinki 150 -300m, a następnie wytrzymałość szybkościowa, która ma wpływ na utrzymanie rytmu płotkowego od 7 do 10 płotka. Szybkość techniczna realizowana była od listopada do września, a najwięcej zrealizowano w miesiącach marcu i kwietniu.   Słowa kluczowe: lekkoatletyka, kobieta, bieg na 100 m przez płotki. Summary             The objective of the research was to analyze  time structure and characteristics of training loads of the hurdler specializing in 100m hurdles realized in the annual training cycle. Training records and training loads  of S.G. , the junior champion of Poland  in 1999 and the youth champion of Poland in 2000, constituted research material. Material concerning training loads was catalogued according to classical division of exercises on account of motor features.             Preparations for the training cycle 1999/2000 lasted 336 days, and 367

  5. Overcoming the initial investment hurdle for advanced biofuels. An analysis of biofuel-related risks and their impact on project financing. Report of ELOBIO subtask 7

    Bole, T.; Londo, M.; Van Stralen, J.; Uslu, A.

    2010-04-01

    The ELOBIO research project aims to develop policies that will help achieve a higher share of biofuels in total transport fuel in a low-disturbing and sustainable way. Workpackage 7 of the ELOBIO project aims at addressing the objective of providing a reliable estimate of the potential and costs of biofuels, given the application of low-disturbing policy measures. More specifically, we seek to evaluate the impact of these biofuel policy measures on the investment climate for second-generation technologies. To this end, we try to answer several sub-questions in a following logical sequence: (1) What are the different factors that contribute to investment risk in biofuels and what are their relative contributions to overall biofuel project risk as perceived by finance providers?; (2) How do these risks translate into cost of capital for different biofuel technologies?; (3) How does cost of capital influence market penetration rates for the different technologies?; and (4) What is the best policy (or policy mix) to overcome the initial investment hurdle for advanced biofuels, thus lowering their cost of capital and achieve wider market deployment?.

  6. Dynamical Monte Carlo investigation of spin reversals and nonequilibrium magnetization of single-molecule magnets

    Liu, Gui-Bin; Liu, Bang-Gui

    2010-01-01

    In this paper, we combine thermal effects with Landau-Zener (LZ) quantum tunneling effects in a dynamical Monte Carlo (DMC) framework to produce satisfactory magnetization curves of single-molecule magnet (SMM) systems. We use the giant spin approximation for SMM spins and consider regular lattices of SMMs with magnetic dipolar interactions (MDI). We calculate spin reversal probabilities from thermal-activated barrier hurdling, direct LZ tunneling, and thermal-assisted LZ tunnelings in the pr...

  7. Microbial inactivation and shelf life comparison of 'cold' hurdle processing with pulsed electric fields and microfiltration, and conventional thermal pasteurisation in skim milk.

    Walkling-Ribeiro, M; Rodríguez-González, O; Jayaram, S; Griffiths, M W

    2011-01-05

    Thermal pasteurisation (TP) is the established food technology for commercial processing of milk. However, degradation of valuable nutrients in milk and its sensory characteristics occurs during TP due to substantial heat exposure. Pulsed electric fields (PEF) and microfiltration (MF) both represent emerging food processing technologies allowing gentle milk preservation at lower temperatures and shorter treatment times for similar, or better, microbial inactivation and shelf stability when applied in a hurdle approach compared to TP. Incubated raw milk was used as an inoculum for the enrichment of skim milk with native microorganisms before PEF, MF, and TP processing. Inoculated milk was PEF-processed at electric field strengths between 16 and 42 kV/cm for treatment times from 612 to 2105 μs; accounting for energy densities between 407 and 815 kJ/L, while MF was applied with a transmembrane flux of 660 L/h m². Milk was TP-treated at 75°C for 24 s. Comparing PEF, MF, and TP for the reduction of the native microbial load in milk led to a 4.6 log₁₀ CFU/mL reduction in count for TP, which was similar to 3.7 log₁₀ CFU/mL obtained by MF (P≥0.05), and more effective than the 2.5 log₁₀ CFU/mL inactivation achieved by PEF inactivation (at 815 kJ/L (Pfield strength, shorter treatment time, larger energy density, and rising temperature the efficacy of PEF/MF increased contrary to MF/PEF. Thus, PEF/MF represents a potential alternative for 'cold' pasteurisation of milk with improved quality. Copyright © 2010 Elsevier B.V. All rights reserved.

  8. The impact of social grant dependency on smallholder maize producers’ market participation in South Africa: Application of the double-hurdle model

    Sikhulumile Sinyolo

    2017-05-01

    Full Text Available Background: Social grants have become an increasingly popular means of improving the welfare of poor households in South Africa and beyond. While the goals of these transfers are to alleviate current poverty as well as to improve human capital capacity, they also have unintended effects, positive or negative, on beneficiary households. A question that has not been adequately addressed in the literature is the role that social grants play in the efforts to commercialise smallholder farming. Aim: The aim of this study was to examine the impact of social grant dependency on the incentives of smallholder maize producers to participate in the market. Setting: The study was done in the rural areas of four districts (Harry Gwala, Umzinyathi, Umkhanyakude and Uthukela in the KwaZulu-Natal province, South Africa. Methods: The study adopted a quantitative research design. A total of 984 households were randomly selected from the four districts, of which 774 had planted maize in the previous season. The analysis was done on the 774 farmers who had planted maize. The double-hurdle model was used for statistical analysis. Results: The results show a negative association between social grant dependency and market participation, suggesting that social grant-dependent households are more subsistent, producing less marketable surplus. Moreover, households with access to social grants sold less quantities of maize in the market, indicating reduced selling incentives. Conclusion: The study indicates that social grants reduce the incentives of smallholder farmers to commercialise their production activities. The results suggest that, while policies aimed at reducing transaction costs would increase smallholder market participation, attention should be paid on how to reduce social grants’ dis-incentive effects. To reduce spill over effects to unintended household members, the study recommends offering part of the grant as ‘in-kind support’, which is

  9. In a hurdle race to the energy transition. From transformations, reforms and innovations; Im Huerdenlauf zur Energiewende. Von Transformationen, Reformen und Innovationen

    Brunnengraeber, Achim; Di Nucci, Maria Rosaria (eds.) [Freie Univ. Berlin (Germany)

    2014-07-01

    The term of the energy transition will not be translated as it travels around the world. He points to the urgency of the conversion of the energy supply for electricity, heat and mobility through renewable energies. Faster than many had expected the energy revolution has reached a pace of expansion, especially in the electricity sector, which many did not expect. However, it is not a voluntary measure, but is forced by the proneness of unsustainable production methods and lifestyles. It is also not a foregone conclusion. The many new initiatives, policies and programs are in competition with an old, fossil and nuclear energy system. From the hurdles that have already been taken in this race, the pace of expansion, innovation as well as the necessary reforms and diverse challenges of the energy transition, this book is dealing. [German] Der Begriff der Energiewende wird bei seinem Lauf um die Welt nicht uebersetzt. Er weist auf die Dringlichkeit der Umstellung der Energieversorgung bei Strom, Waerme und Mobilitaet durch erneuerbare Energien hin. Schneller als von vielen erwartet hat die Energiewende vor allem im Strombereich ein Ausbautempo erreicht, mit dem viele nicht gerechnet hatten. Sie ist allerdings keine freiwillige Massnahme, sondern wird durch die Krisenhaftigkeit von nicht nachhaltigen Produktions- und Lebensweisen erzwungen. Sie ist auch kein Selbstlaeufer. Die vielfaeltigen neuen Initiativen, Massnahmen und Programme befinden sich im Wettbewerb mit einem alten, fossilen und nuklearen Energiesystem. Von den Huerden, die in diesem Wettlauf bereits genommen wurden, vom Tempo des Ausbaus, von Innovationen sowie von den notwendigen Reformen und vielfaeltigen Herausforderungen der Energiewende handelt dieses Buch.

  10. Pessoas que vivem sós – quem são elas nas oito maiores capitais brasileiras Singles in the eight biggest capital cities in Brazil – who they are

    José Augusto Giesbrecht da Silveira

    2011-08-01

    Full Text Available O Brasil apresenta uma das dez maiores taxas de participação de indivíduos que vivem sós em relação ao total da população, sendo que eles somam cerca de 10% dos habitantes do país. Este estudo se baseia nos microdados dos censos demográficos de 1970, 1980, 1991 e 2000, e objetiva apresentar a caracterização dos grupos pelos quais se subdivide este segmento da população e descortinar tendências gerais. Nas oito maiores capitais brasileiras, em termos populacionais, este segmento apresenta uma composição bastante variada com relação a sexo, idade, renda, alfabetização, aposentadoria e posse de domicílio, tanto em uma mesma cidade, ao longo do tempo, como entre cidades, em um mesmo instante de tempo. Embora a diversidade seja a regra geral na composição do segmento, o estudo identifica e apresenta algumas tendências amplas: o segmento cresce mais rapidamente que o aumento da população em geral; está havendo um aumento da idade média das pessoas que o compõem (envelhecimento; há predominância de mulheres; e em matéria de rendimentos, há maior incidência de rendas mais baixas e mais altas que de rendas médias. É importante considerar o número de pessoas que vivem sozinhas e sua caracterização sociodemográfica quando se abordam questões ligadas a consumo, produção de bens e serviços e seus desdobramentos.Brazil is in the global top ten in terms of the percentage of individuals who live alone in relation to the rest of the population; they make up some 10% of the country’s total population. This study, based on micro data from the demographic censuses of 1970, 1980, 1991, and 2000 and aims to characterize the groups into which this segment is divided and uncover general trends. In the eight largest Brazilian capitals, this segment ranges widely in gender, age, income, literacy, and home ownership, whether in the same city over a period of time, or among different cities at the same instant of time. Although diversity is the general rule in the composition of this segment, this study identifies and presents a few broad tendencies: this segment grows at a faster pace than the increase in population in general; there is an increase in the average age of the peoplecomposing it (aging; women predominate; and there are more low and high incomes than median incomes. It is important to consider the number of people that live alone and their socio-demographic characterization when addressing issues related to the consumption and production of goods and services and their ramifications.

  11. Dynamical Monte Carlo investigation of spin reversal and nonequilibrium magnetization of single-molecule magnets

    Liu, Gui-Bin; Liu, Bang-Gui

    2010-10-01

    In this paper, we combine thermal effects with Landau-Zener (LZ) quantum tunneling effects in a dynamical Monte Carlo (DMC) framework to produce satisfactory magnetization curves of single-molecule magnet (SMM) systems. We use the giant spin approximation for SMM spins and consider regular lattices of SMMs with magnetic dipolar interactions (MDIs). We calculate spin-reversal probabilities from thermal-activated barrier hurdling, direct LZ tunneling, and thermal-assisted LZ tunnelings in the presence of sweeping magnetic fields. We do systematical DMC simulations for Mn12 systems with various temperatures and sweeping rates. Our simulations produce clear step structures in low-temperature magnetization curves, and our results show that the thermally activated barrier hurdling becomes dominating at high temperature near 3 K and the thermal-assisted tunnelings play important roles at intermediate temperature. These are consistent with corresponding experimental results on good Mn12 samples (with less disorders) in the presence of little misalignments between the easy axis and applied magnetic fields, and therefore our magnetization curves are satisfactory. Furthermore, our DMC results show that the MDI, with the thermal effects, have important effects on the LZ tunneling processes, but both the MDI and the LZ tunneling give place to the thermal-activated barrier hurdling effect in determining the magnetization curves when the temperature is near 3 K. This DMC approach can be applicable to other SMM systems and could be used to study other properties of SMM systems.

  12. Your Biggest Game: Interview with Dave Ellis.

    Sparks, Dennis

    2001-01-01

    Interviews Dave Ellis, president of the Brande Foundation, who promotes life coaching to help leaders become more creative and effective by making them happier, more satisfied human beings. It provides an opportunity for people to look at all areas of their lives, determine what they want in these areas, and have the coach help them develop…

  13. CCS. Coal's biggest challenge

    Zheng, Ligang [CanmentENERGY, Ottawa, ON (Canada)

    2013-07-01

    Coal, next to oil, is the second most important energy source due to wide distribution and large quantity. Coal is a very economical fuel about $0.50/GJ-$2.50/GJ (NG usually is $6/GJ-$12/GJ. Currently it is $4.03/GJ for July, 2011 delivery). It is the largest fuel source for power generation: 40% world electricity is generated by coal; its shares are about 80% in China and 50% in the U.S. An extensive coal based energy infrastructure has been built up over the years and is in good service.

  14. Smashing physics inside the world's biggest experiment

    Butterworth, Jon

    2014-01-01

    The discovery of the Higgs boson made headlines around the world. Two scientists, Peter Higgs and Francois Englert, whose theories predicted its existence, shared a Nobel Prize. The discovery was the culmination of the largest experiment ever run, the ATLAS and CMS experiments at CERN's Large Hadron Collider. But what really is a Higgs boson and what does it do? How was it found? And how has its discovery changed our understanding of the fundamental laws of nature? And what did it feel like to be part of it? Jon Butterworth is one of the leading physicists at CERN and this book is the first popular inside account of the hunt for the Higgs. It is a story of incredible scientific collaboration, inspiring technological innovation and ground-breaking science. It is also the story of what happens when the world's most expensive experiment blows up, of neutrinos that may or may not travel faster than light, and the reality of life in an underground bunker in Switzerland. This book will also leave you with a working...

  15. Iran plans world's fourth biggest nuclear programme

    Anon.

    1977-01-01

    Power requirements of projected power generation to 1992, and fuel reserves, in Iran are submitted. The current nuclear programme is outlined. 34000 MWe of nuclear power is planned for the end of the century. (U.K.)

  16. Countering the biggest risk of all.

    Slywotzky, Adrian J; Drzik, John

    2005-04-01

    Corporate treasurers and chief financial officers have become adept at quantifying and managing a wide variety of risks: financial (for example, currency fluctuations), hazard (chemical spills), and operational (computer system failures). To defend themselves, they use tried-and-true tools such as hedging, insurance, and backup systems. Some companies have even adopted the concept of enterprise risk management, integrating available risk management techniques in a comprehensive, organization-wide approach. But most managers have not addressed in a systematic way the greatest threat of all--strategic risks, the array of external events and trends that can devastate a company's growth trajectory and shareholder value. Strategic risks go beyond such familiar challenges as the possible failure of an acquisition or a product launch. A new technology may overtake your product. Gradual shifts in the market may slowly erode one of your brands beyond the point of viability. Or rapidly shifting customer priorities may suddenly change your industry. The key to surviving these strategic risks, the authors say, is knowing how to assess and respond to them. In this article, they lay out a method for identifying and responding to strategic threats. They categorize the risks into seven major classes (industry, technology, brand, competitor, customer, project, and stagnation) and describe a particularly dangerous example within each category. The authors also offer countermeasures to take against these risks and describe how individual companies (American Express, Coach, and Air Liquide, among them) have deployed them to neutralize a threat and, in many cases, capitalize on it. Besides limiting the downside of risk, strategic-risk management forces executives to think more systematically about the future, thus helping them identify opportunities for growth.

  17. Preparing for the biggest experiment on earth

    2007-01-01

    "An international team of over 2'000 scientists, led by Professor Tejinder Virdee from Imperial College London's Department of Physics is stepping up preparations for the world's largest ever physics experiment, starting next year at CERN near Geneva, Switzerland." (1 page)

  18. Rooting the biggest problems in physics

    Javadi, Hossein; Forouzbakhsh, Farshid

    2016-01-01

    to combine these three theories of classical mechanics, quantum mechanics and relativity in order to reach to a unique physics. Eventually, by answering the unanswered questions, the physics problems will be solved. In this paper, the stems of physics problems are expressed and the solution of them...

  19. A giant takes on physics' biggest questions

    Overbye, Dennis

    2007-01-01

    "Physics, after all, is supposed to be a cerebral pursuit. But this cavern almost measureless to the eye, stuffed as it is with an Eiffet Tower's worth of metal, eight-story wheels of gold fan-shape boxes, thousands of miles of wire and fat ductlike coils, echoes with the shriek of power tools, the whine of pumps and cranes, beeps and clanks from wrenches, hammers, screwdrivers and the occasional falling bolt." (6 pages)

  20. single crystals

    2018-05-18

    May 18, 2018 ... Abstract. 4-Nitrobenzoic acid (4-NBA) single crystals were studied for their linear and nonlinear optical ... studies on the proper growth, linear and nonlinear optical ..... between the optic axes and optic sign of the biaxial crystal.

  1. Singled out?

    Waller, Frank

    2004-03-01

    The increasing use of single use medical devices is being driven by a growing awareness of iatrogenic (from the Greek; caused by the doctor) and nosocomial infections. Public health perceptions relating to transmissible spongiform encephalopathies, specifically variant Creutzfeldt-Jakob disease (vCJD), the Human Immunodeficiency Virus (HIV) and Hepatitis B are high on the political agenda and a matter of concern to healthcare professionals.

  2. A metabolic way to investigate related hurdles causing poor bioavailability in oral delivery of isoacteoside in rats employing ultrahigh-performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry.

    Cui, Qingling; Pan, Yingni; Yan, Xiaowei; Qu, Bao; Liu, Xiaoqiu; Xiao, Wei

    2017-02-28

    Isoacteoside (ISAT), a phenylethanoid glycoside that acts as the principal bioactive component in traditional Chinese medicines, possesses broad pharmacological effects such as neuroprotective, antihypertensive and hepatoprotective activities. However, its pharmaceutical development has been severely limited due to the poor oral bioavailability. It is essential and significant to investigate related hurdles leading to the poor bioavailability of isoacteoside. Whole animal metabolism studies were conducted in rats, followed by metabolic mechanism including gastrointestinal stability, intestinal flora metabolism and intestinal enzyme metabolism employing the powerful method ultrahigh-performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry (UPLC/QTOF-MS/MS). A simple, rapid and sensitive method has been developed which comprehensively revealed the underlying cause of poor bioavailability of ISAT in a metabolic manner. The prototype of ISAT and its combined metabolites have not been detected in plasma. Furthermore, the residual content of the parent compound in in vitro experiments was approximately 59%, 5% and barely none in intestinal bacteria, intestinal S9 and simulated intestinal juice at 6 h, respectively. The present work has demonstrated that the factors causing the poor bioavailability of isoacteoside should be attributed to the metabolism. In general, the metabolism that resulted from intestinal flora and intestinal enzymes were predominant reasons giving rise to the poor bioavailability of ISAT, which also suggested that metabolites might be responsible for the excellent pharmacological effect of ISAT. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  3. Overcoming Hurdles Implementing Multi-skilling Policies

    2015-03-26

    skilled workforce? Chapter II will communicate important concepts found in the literature on skill proficiency topics. These topics include skill...training methods that might improve learning and retention during the acquisition phase. 10 The active interlock modeling (AIM) protocol is a dyadic ...retention, as found in 43 Chapter 2. These techniques include dyadic training methods, overlearning, feedback, peer support, and managerial support

  4. Oil and gas supply : hurdles and opportunities

    Giusti, L.

    2006-01-01

    The socioeconomic development in Latin America was discussed with reference to its abundant and diverse resources. Despite its large population, Latin America represents only 6 per cent of the world gross domestic product (GDP) and a less than 6 per cent of the total world trading. This presentation described the problems of large deficits, poor economic policies, large debt and corruption that provoked inflation, economic slowdown, and foreign debt in Latin America. Policy makers agreed that reforms were needed if Latin American economies were to grow more than 6 per cent a year, and to lower the number of people living in poverty in the region. The second-generation reform for Latin America was meant to promote economic development without inflation. It is based on quality public sector governance; fiscal strengthening; an enhanced legal and regulatory framework; efficient financial markets; and, labour and market reform. This presentation also discussed the oil and gas industry's contention with the perceptions that the economic crisis in Latin America was caused by globalization, international trade and acquisitive industrialized countries. An initiative was launched in 1994 to build an integrated energy data bank, evaluate existing interconnections among Latin American countries, and identify barriers for a larger integration to facilitate and improve commercial activities. It was emphasized that while the United States has a large deficit of oil, Canada and Latin America have large surpluses of energy resources, which if developed efficiently and effectively, can be a leading engine of regional development and an important contributor to global competitiveness. Canada is the largest supplier of energy, including oil, natural gas and electricity to the United States, the world's largest energy consumer and largest oil and gas market. Mexico and Brazil were identified as the other 2 large economies in the region's energy chain, but Mexico is self sufficient and Brazil has a modest dependency. The important players on the supply side include Mexico, Brazil, Venezuela and Trinidad/Tobago. Also, Colombia is a player with its excellent exploration and production model, its stability and institutional strength. It was suggested that Bolivia could become an important player if changes take place to promote the development of its huge natural gas resources

  5. Bone Tissue Donation: Tendency and Hurdles.

    El Hage, S; Dos Santos, M J; de Moraes, E L; de Barros E Silva, L B

    2018-03-01

    The aim of this study was to identify the percentage of bone tissue donation in a brain death situation and the tendency of donation rate of this tissue in an organ procurement organization in the county of Sao Paulo from 2001 to 2016. It is a retrospective and quantitative study, based on the Organ and Tissue Donation Term of donors who died of brain death between 2001 and 2016. A logistic regression model was applied, and the odds of donation were identified throughout the years, regarding the odds ratio different from zero. Finally, it was measured the accuracy of the odds ratio through the confidence interval. The analysis has shown a significant change on the trend of bone donation (P 1, indicating that the donation rate has increased. However, the percentage of growth is still considered low. The study evidences a growth trend regarding the donation of bone tissue, but the percentage is still too low to adequately meet the demand of patients who need this modality of therapeutic intervention. It is believed that educational campaigns of donation are not emphasizing the donation of tissues for transplantation, which may be directly impacting their consent rates. Copyright © 2018 Elsevier Inc. All rights reserved.

  6. Defining the Critical Hurdles in Cancer Immunotherapy

    Fox, BA; Schendel, D.J.; Butterfield, L.H.; Aamdal, S.; Allison, J.P.; Ascierto, P.A.; Atkins, M.B.; Bartunkova, J.; Bergmann, L.; Berinstein, N.; Bonorino, C.C.; Borden, E.; Bramson, J.L.; Britten, C.M.; Cao, X.; Carson, W.E.; Chang, A.E.; Characiejus, D.; Choudhury, A.R.; Coukos, G.; de Gruijl, T.D.; Dillman, R.O.; Dolstra, H.; Dranoff, G.; Durrant, L.G.; Finke, J.H.; Galon, J.; Gollob, J.A.; Gouttefangeas, C.; Grizzi, F.; Guida, M.; Hakansson, L.; Hege, K.; Herberman, R.B.; Hodi, F.S.; Hoos, A.; Huber, C.; Hwu, P.; Imai, K.; Jaffee, E.M.; Janetzki, S.; June, C.H.; Kalinski, P.; Kaufmann, H.L.; Kawakami, K.; Kawakami, Y.; Keilholtz, U.; Khleif, S.N.; Kiessling, R.; Kotlan, B.; Kroemer, G.; Lapointe, R.; Levitsky, H.I.; Lotze, M.T.; Di Maio, M.; Marschner, J.P.; Mastrangelo, M.J.; Masucci, G.; Melero, I.; Nelief, C.; Murphy, W.J.; Nelson, B.; Nicolini, A.; Nishimura, M.I.; Odunsi, K.; Ohashi, P.S.; O'Donnell-Tormey, J.; Old, L.J.; Ottensmeier, C.; Papamichail, M.; Parmiani, G.; Pawelec, G.; Proietti, E.; Qin, S.; Rees, R.; Ribas, A.; Ridolfi, R.; Ritter, G.; Rivoltini, L.; Romero, P.J.; Salem, M.L.; Scheper, R.J.; Seliger, B.; Sharma, P.; Shiku, H.; Singh-Jasuja, H.; Song, W.; Straten, P.T.; Tahara, H.; Tian, Z.; van der Burg, S.H.; von Hoegen, P.; Wang, E.; Welters, M.J.; Winter, H.; Withington, T.; Wolchok, J.D.; Xiao, W.; Zitvogel, L.; Zwierzina, H.; Marincola, F.M.; Gajewski, T.F.; Wigginton, J.M.; Disis, M.L.A.

    2011-01-01

    Scientific discoveries that provide strong evidence of antitumor effects in preclinical models often encounter significant delays before being tested in patients with cancer. While some of these delays have a scientific basis, others do not. We need to do better. Innovative strategies need to move

  7. Biological aspects of chondrosarcoma: Leaps and hurdles.

    Mery, Benoîte; Espenel, Sophie; Guy, Jean-Baptiste; Rancoule, Chloé; Vallard, Alexis; Aloy, Marie-Thérèse; Rodriguez-Lafrasse, Claire; Magné, Nicolas

    2018-06-01

    Chondrosarcomas are characterized by their chemo- and radioresistance leading to a therapeutic surgical approach which remains the only available treatment with a 10-year survival between 30% and 80% depending on the grade. Non-surgical treatments are under investigation and rely on an accurate biological understanding of drug resistance mechanisms. Novel targeted therapy which represents a new relevant therapeutic approach will open new treatment options by targeting several pathways responsible for processes of proliferation and invasion. Survival pathways such as PI3K, AKT, mTOR and VEGF have been shown to be involved in proliferation of chondrosarcoma cells and antiapoptotic proteins may also play a relevant role. Other proteins such as p53 or COX2 have been identified as potential new targets. This review provides an insight into the biological substantial treatment challenges of CHS and focuses on improving our understanding of CH biology through an overview of major signaling pathways that could represent targets for new therapeutic approaches. Copyright © 2018 Elsevier B.V. All rights reserved.

  8. Humans in space the psychological hurdles

    Kanas, Nick

    2015-01-01

    Using anecdotal reports from astronauts and cosmonauts, and the results from studies conducted in space analog environments on Earth and in the actual space environment, this book broadly reviews the various psychosocial issues that affect space travelers.  Unlike other books that are more technical in format, this text is targeted for the general public.  With the advent of space tourism and the increasing involvement of private enterprise in space, there is now a need to explore the impact of space missions on the human psyche and on the interpersonal relationships of the crewmembers. Separate chapters of the book deal with psychosocial stressors in space and in space analog environments; psychological, psychiatric, interpersonal, and cultural issues pertaining to space missions; positive growth-enhancing aspects of space travel; the crew-ground interaction; space tourism; countermeasures for dealing with space; and unique aspects of a trip to Mars, the outer solar system, and interstellar travel. .

  9. Global Studies: Hurdles to Program Development

    Campbell, Patricia J.; Masters, Paul E.; Goolsby, Amy

    2004-01-01

    In this article, we examine a new global studies program that departs from the traditional state-centric approach and uses a geocentric, or earth-centered, approach that emphasizes the roles of individuals, grassroots organizations, cultural groups, and international organizations in an attempt to help students conceptualize global events and…

  10. GIS in oceanography: Status, hurdles and prospects

    Kunte, P.D.

    stream_size 5 stream_content_type text/plain stream_name Remote_Sens_GIS_Environ_Plan_1995_575.pdf.txt stream_source_info Remote_Sens_GIS_Environ_Plan_1995_575.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset...

  11. Hurdles on the road to personalized medicine

    Tursz, Thomas; Bernards, Rene

    2015-01-01

    Cancer treatment is slowly shifting from an approach in which the tissue of origin and the histology were the guiding principles for the choice of chemotherapy towards a genotype-centric approach in which the changes in the cancer genome are used to select patients for treatment with highly

  12. Legal hurdles for gastroenterologists in India.

    Nagpal, Neeraj

    2017-05-01

    Litigation and compensation claims have started occurring with increasing frequency against gastroenterologists in India. A study of few such cases decided by Indian Courts shows that commonest reason for allegations of negligence being upheld by Indian Courts is an improper consent being taken. Professional organisations need to focus on these issues more aggressively than has been done in the past. Judgments which do not appear to be in conformity with standard medical practices need to be challenged in higher courts, failing in which they would become precedents for future similar judgments.

  13. Genetic privacy in sports: clearing the hurdles.

    Callier, Shawneequa

    2012-12-01

    As genomic medicine continues to advance and inform clinical care, knowledge gained is likely to influence sports medicine and training practices. Susceptibility to injury, sudden cardiac failure, and other serious conditions may one day be tackled on a subclinical level through genetic testing programs. In addition, athletes may increasingly consider using genetic testing services to maximize their performance potential. This paper assesses the role of privacy and genetic discrimination laws that would apply to athletes who engage in genetic testing and the limits of these protections.

  14. Single beam Fourier transform digital holographic quantitative phase microscopy

    Anand, A., E-mail: arun-nair-in@yahoo.com; Chhaniwal, V. K.; Mahajan, S.; Trivedi, V. [Optics Laboratory, Applied Physics Department, Faculty of Technology and Engineering, M.S. University of Baroda, Vadodara 390001 (India); Faridian, A.; Pedrini, G.; Osten, W. [Institut für Technische Optik, Universität Stuttgart, Pfaffenwaldring 9, 70569 Stuttgart (Germany); Dubey, S. K. [Siemens Technology and Services Pvt. Ltd, Corporate Technology—Research and Technology Centre, Bangalore 560100 (India); Javidi, B. [Department of Electrical and Computer Engineering, U-4157, University of Connecticut, Storrs, Connecticut 06269-2157 (United States)

    2014-03-10

    Quantitative phase contrast microscopy reveals thickness or height information of a biological or technical micro-object under investigation. The information obtained from this process provides a means to study their dynamics. Digital holographic (DH) microscopy is one of the most used, state of the art single-shot quantitative techniques for three dimensional imaging of living cells. Conventional off axis DH microscopy directly provides phase contrast images of the objects. However, this process requires two separate beams and their ratio adjustment for high contrast interference fringes. Also the use of two separate beams may make the system more vulnerable to vibrations. Single beam techniques can overcome these hurdles while remaining compact as well. Here, we describe the development of a single beam DH microscope providing whole field imaging of micro-objects. A hologram of the magnified object projected on to a diffuser co-located with a pinhole is recorded with the use of a commercially available diode laser and an arrayed sensor. A Fourier transform of the recorded hologram directly yields the complex amplitude at the image plane. The method proposed was investigated using various phase objects. It was also used to image the dynamics of human red blood cells in which sub-micrometer level thickness variation were measurable.

  15. The dragon of Kaohsiung. The new soccer stadium in Taiwan's second biggest city will generate more than one million kWh of solar power per annum; Der Drache von Kaohsiung. Das neue Stadion in Taiwans zweitgroesster Stadt soll ueber eine Million Kilowattstunden Solarstrom jaehrlich liefern

    Hirsch, Matthew; Wagner, Neelke

    2009-10-15

    The new stadium at Kaohsiung has a spectacular architecture which raised attention world-wide. The public and experts call it the ''flying dragon''. Apart from the sports fans, also the fans of photovoltaic power generation will profit: with an installed capacity of 1 MW, it has the biggest photovoltaic system of any sports facility in the world. (orig.)

  16. Plasma-implantation-based surface modification of metals with single-implantation mode

    Tian, X. B.; Cui, J. T.; Yang, S. Q.; Fu, Ricky K. Y.; Chu, Paul K.

    2004-12-01

    Plasma ion implantation has proven to be an effective surface modification technique. Its biggest advantage is the capability to treat the objects with irregular shapes without complex manipulation of target holder. Many metal materials such as aluminum, stainless steel, tool steel, titanium, magnesium etc, has been treated using this technique to improve their wear-resistance, corrosion-resistance, fatigue-resistance, oxidation-resistance, bio-compatiblity etc. However in order to achieve thicker modified layers, hybrid processes combining plasma ion implantation with other techniques have been frequently employed. In this paper plasma implantation based surface modification of metals using single-implantation mode is reviewed.

  17. Hurdle technology to preserve the 'Golden' papaya post harvest quality;Metodos combinados para preservar a qualidade pos-colheita do mamao 'Golden' tipo exportacao

    Molinari, Andrea Cristina Fialho, E-mail: molinari_af@yahoo.co

    2007-07-01

    significant differences among papayas submitted to different treatments. A synergism was verified on the techniques combination, with the best results obtained from the association of CP + PEabs + gamma-irradiation at 0.4 kGy, which reached a total storage period of 35 days. Thus, that is the post harvest hurdle technology recommend for exporting 'Golden' papayas to markets with quarantine restrictions to fruit-flies (author)

  18. Current Developments in Prokaryotic Single Cell Whole Genome Amplification

    Goudeau, Danielle; Nath, Nandita; Ciobanu, Doina; Cheng, Jan-Fang; Malmstrom, Rex

    2014-03-14

    Our approach to prokaryotic single-cell Whole Genome Amplification at the JGI continues to evolve. To increase both the quality and number of single-cell genomes produced, we explore all aspects of the process from cell sorting to sequencing. For example, we now utilize specialized reagents, acoustic liquid handling, and reduced reaction volumes eliminate non-target DNA contamination in WGA reactions. More specifically, we use a cleaner commercial WGA kit from Qiagen that employs a UV decontamination procedure initially developed at the JGI, and we use the Labcyte Echo for tip-less liquid transfer to set up 2uL reactions. Acoustic liquid handling also dramatically reduces reagent costs. In addition, we are exploring new cell lysis methods including treatment with Proteinase K, lysozyme, and other detergents, in order to complement standard alkaline lysis and allow for more efficient disruption of a wider range of cells. Incomplete lysis represents a major hurdle for WGA on some environmental samples, especially rhizosphere, peatland, and other soils. Finding effective lysis strategies that are also compatible with WGA is challenging, and we are currently assessing the impact of various strategies on genome recovery.

  19. Reviews Book: Sustainable Energy—Without the Hot Air Equipment: Doppler Effect Unit Book: The Physics of Rugby Book: Plastic Fantastic: How the Biggest Fraud in Physics Shook the Scientific World Equipment: Brunel Eyecam Equipment: 200x Digital Microscope Book: The Atom and the Apple: Twelve Tales from Contemporary Physics Book: Physics 2 for OCR Web Watch

    2009-09-01

    WE RECOMMEND Sustainable Energy—Without the Hot Air This excellent book makes sense of energy facts and figures Doppler Effect Unit Another simple, effective piece of kit from SEP Plastic Fantastic: How the Biggest Fraud in Physics Shook the Scientific World Intriguing and unique write-up of an intellectual fraud case Brunel Eyecam An affordable digital eyepiece for your microscope 200x Digital Microscope An adjustable digital flexcam for classroom use The Atom and the Apple: Twelve Tales from Contemporary Physics A fascinating round-up of the recent history of physics WORTH A LOOK The Physics of Rugby Book uses sport analogy and context to teach physics concepts Physics 2 for OCR Essential textbook for the course but otherwise pointless WEB WATCH Some free teaching materials are better than those you'd pay for

  20. Single Audit: Single Audit Act Effectiveness Issues

    Thompson, Sally

    2002-01-01

    As discussed in the report we are releasing today, our work to review agency actions to ensure that recipients take timely and appropriate corrective actions to fix audit findings contained in single...

  1. Single-Sex Classrooms

    Protheroe, Nancy

    2009-01-01

    Although single-sex education was once the norm in the U.S., the practice has largely been confined to private schools for more than a century. However, with the introduction of the final version of the U.S. Department of Education's so-called single-sex regulations in 2006, public schools were allowed greater flexibility to offer single-sex…

  2. Superconducting Single Photon Detectors

    Dorenbos, S.N.

    2011-01-01

    This thesis is about the development of a detector for single photons, particles of light. New techniques are being developed that require high performance single photon detection, such as quantum cryptography, single molecule detection, optical radar, ballistic imaging, circuit testing and

  3. Single frequency intracavity SRO

    Abitan, Haim; Buchhave, Preben

    2000-01-01

    Summary form only given. A single resonance optical parametric oscillator (SRO) is inserted intracavity to a CW high power, single frequency, and ring Nd:YVO4 laser. We obtain a stable single frequency CW SRO with output at 1.7-1.9 μm (idler) and a resonating signal at 2.3-2.6 μm. The behavior...

  4. Single atom oscillations

    Wiorkowski, P.; Walther, H.

    1990-01-01

    Modern methods of laser spectroscopy allow the study of single atoms or ions in an unperturbed environment. This has opened up interesting new experiments, among them the detailed study of radiation-atom coupling. In this paper, the following two experiments dealing with this problem are reviewed: the single-atom maser and the study of the resonance fluorescence of a single stored ion. The simplest and most fundamental system for studying radiation-matter coupling is a single two-level atom interacting with a single mode of an electromagnetic field in a cavity. This problem received a great deal of attention shortly after the maser was invented

  5. World's Biggest Astronomy Event on the World-Wide

    1996-06-01

    `Astronomy On-Line' will connect students all over Europe Astronomy On-Line is a major, all-European project that will take place in conjunction with the 4th European Week for Scientific and Technological Culture later this year. It is based on intensive use of the World-Wide-Web (WWW) and represents the first large-scale attempt in the world to bring together pupils and their teachers all over one continent to explore challenging scientific questions, using modern communication tools, both for obtaining and for communicating information. The programme will be carried out in a collaboration between the European Association for Astronomy Education (EAAE) [1] and the European Southern Observatory, and together with the European Commission (EC). The active phase of Astronomy On-Line will start on October 1 and reach a climax on November 18 - 22, 1996 . What is `Astronomy On-Line'? In this project, a large number of students and their teachers at schools all over Europe, together with professional and amateur astronomers and others interested in astronomy, will become associated in a unique experience that makes intensive use of the vast possibilities of the World-Wide-Web (WWW). Although the exact number of participants will not be known until the beginning of October, it is expected to run into thousands, possibly many more. The unusual size and scope of Astronomy On-Line will contribute to make it an important all-European media event. The central idea is that the participants, through the WWW, will `meet' in a `marketplace' where a number of different `shops' will be available, each of which will tempt them with a number of exciting and educational `events', carefully prepared to cater for different age groups, from 12 years upwards. The events will cover a wide spectrum of activities, some of which will be timed to ensure the proper progression of this very complex project through its main phases. The benefits In fact, Astronomy On-Line will be the first, internationally organised and fully structured programme which offers a large number of students the possibility to familiarize themselves with the use of this communication tool of the future, unequalled possibilities for fruitful international communication, and at the same time to learn much about the science and technology of astronomy, including the scientific methods now being practiced by the world's scientists. Within this framework, they can actively contribute to co-ordinated sub-programmes that will draw on the combined forces and ingenuity of participants from all areas of Europe. There are many other side benefits, of course, such as stimulating schools to go on-line, prompting international cooperation among the young people, etc. Another important aspect is that the programme will lead to natural involvement of business and industrial partners in local areas of the participating groups. Also its unique character and international implications will be very inviting for extensive media coverage, both in human and scientific/technological terms. The organisation An enormous programme like Astronomy On-Line obviously represents a tremendous challenge to the organisers, and careful planning is crucial to its success. This is ensured by the active participation of experienced educators, scientists and engineers in most European countries, united by the common goal to prepare a well-structured event that is exciting for everybody and which has clearly defined roles and responsibilities for all involved parties. An International Steering Committee (ISC) has been established for the programme. The ICS is responsible for the planning of the main activities, together with National Steering Committees (NSC) which will coordinate the Programme in their respective countries. The NSC's are still in the process of being formed and for the time being, most EAAE National Representatives will act as contact points for the programme in their areas. Full information about the organisational and technical aspects of the Programme is available on two central WWW nodes. They will be continuously updated as the programme is specified in increasing detail. The Astronomy On-Line WWW Homepages can be reached under: http://www.eso.org/outreach/spec-prog/aol/ and http://www.algonet.se/~sirius/eaae.htm Announcements about National WWW Homepages for the Programme, now being set up by the NCS's, will follow on the above WWW Homepages. Participation The NSCs will soon issue a call for participation to interested schools, astronomy clubs and other astronomy-interested persons in their respective areas. The deadline for registration is October 1, 1996 , the day when the first active phase of the Programme will start. Participants must register with the appropriate NSC. Participating groups may consist of at least one teacher and his/her students or of one or more astronomy enthousiasts. Each group must have access to the WWW. If access is not yet available at the school, this may be arranged by `sponsors' in the local area. These may be planetaria, science institutes, business undertakings (e.g. in the field of electronics, computers, communication, etc.), industrial firms or private benefactors. All communication via the WWW will take place in English. Only registered groups can participate actively. The main phases Astronomy On-Line will be divided into three phases, lasting from October 1 to November 22, 1996, and reflecting the gradual progression of the associated activities. Phase 1 will last about six weeks, from early October to the beginning of the 4th European Week for Scientific and Technological Culture. During this period, the participating groups will have the possibility of preparing themselves for the active participation, for instance to familiarize themselves with the hard- and software as well as to consider specific programme opportunities, now becoming available on the WWW pages. Regional or international `clusters of groups' may form at this time. Phase 2 will take place on Monday, November 18 and Tuesday, November 19, 1996. On these and the three following days ( Phase 3 : November 20--22), the `active period' will be in the six-hour interval from 15h to 21h UT [2]. Various events are planned to happen at certain times and in certain places on the WWW, keeping the programme lively and enhancing the interaction by ensuring continued attention and expectation by the participants. During Phases 2 and 3, nine or more `shops' will be available in the Astronomy On-Line WWW `marketplaces' for consultation by the participants. They will display a variety of `goods' (activities) at different levels of complexity in order to attract participants of different age groups, among others: General information; Collaborative projects which require observations by many groups all over the continent; Real astronomical observations to be submitted and executed with telescopes at participating, professional observatories; Prepared exercises which may include guided searches on the WWW; Opportunities to talk to professional astronomers, etc. More details are available at the above mentioned WWW sites. Ideas for further activities are now being actively solicited by the Steering Committees. At the end, the various results will be presented on the WWW in the form of short reports which may be commented upon, as far as possible in real time. A `final event' which will `unite' participants from all over Europe will be planned on the last day. Notes: [1] The EAAE was founded in November 1994 (cf. ESO Press Release 17/94 of 2 December 1994) and now has several hundred members located in virtually all European countries; most are secondary school physics teachers with a particular interest in astronomy. [2] This period of the day has been chosen to allow students to participate outside the the normal school hours, and by taking into account the time zones across Europe (from UT in the West to UT+2h in East). How to obtain ESO Press Information ESO Press Information is made available on the World-Wide Web (URL: http://www.eso.org../). ESO Press Photos may be reproduced, if credit is given to the European Southern Observatory.

  6. The biggest investment in the history of Slovakia

    Anon

    2009-01-01

    On 11 June 2009 the General Director and Chairman of the Board of Directors of Slovenske elektrarne Paolo Ruzzini and the Prime Minister of the Slovak Republic Robert Fico announced the signature of contracts with the main suppliers for the completion of units 3 and 4 of Mochovce Nuclear Power Plant. Planned investment of Eur 2.775 billion by 2013 for the Mochovce completion is an important commitment for us and especially in this time, such investment can mitigate the impact of global slowdown in economic growth which impacts Slovakia but also other economies of the world. (author)

  7. Mega starbirth cluster is biggest, brightest and hottest ever seen

    2003-10-01

    Artist’s impression of the Lynx Arc hi-res Size hi-res: 4519 kb Credits: European Space Agency, NASA and Robert A.E. Fosbury (European Space Agency/Space Telescope-European Coordinating Facility, Germany) Artist’s impression of the Lynx Arc This illustration shows an artist’s impression of the so-called Lynx arc, a newly identified distant super-cluster that contains a million blue-white stars twice as hot as similar stars in our Milky Way galaxy. The Lynx arc is one million times brighter than the well-known Orion Nebula, a nearby prototypical ‘starbirth’ region visible with small telescopes. The stars in the Lynx arc are more than twice as hot as the Orion Nebula’s central stars, with surface temperatures up to 80 000°C. Though there are much bigger and brighter star-forming regions than the Orion Nebula in our local Universe, none are as bright as the Lynx arc, nor do they contain such large numbers of hot stars. The stars are so hot that a very large fraction of their light is emitted in the ultraviolet that makes the gas glow with the green and red colours illustrated here. The so-called Lynx Arc is one million times brighter than the well-known Orion Nebula, a nearby prototypical 'starbirth' region visible with small telescopes. The newly identified super-cluster contains a million blue-white stars that are twice as hot as similar stars in our Milky Way galaxy. It is a rarely glimpsed example of the early days of the Universe where furious firestorms of starbirth blazed across the skies. The spectacular cluster's opulence is dimmed when seen from Earth only by the fact that it is 12 000 million light years away. The discovery of this unique and tantalising object was the result of a systematic study of distant clusters of galaxies carried out with major X-ray, optical and infrared telescopes, including the NASA/ESA Hubble Space Telescope, ROSAT and the Keck Telescopes. Bob Fosbury, of the European Space Agency's Space Telescope-European Coordinating Facility in Germany, and a team of international co-authors report the discovery in the 20 October 2003 issue of the Astrophysical Journal. The mega-cluster of stars appears as a puzzling red arc behind a distant galaxy cluster 5400 million light-years away in the northern constellation of Lynx. The arc is the stretched and magnified image of a mysterious celestial object about 12 000 million light-years away (at a redshift of 3.36), far beyond the cluster of galaxies. This means that the remote source existed when the Universe was less than 2000 million years old. Fosbury and colleagues first tried to identify the arc by analysing the light from the object, but the team was not able to recognise the pattern of colours in the spectral signature of the remote object. While looking for matches with the colour spectrum, Fosbury realised that the light was related to that of the nearby Orion Nebula, a star-forming region in our own Milky Way. However where the Orion Nebula is powered by only four hot and bright blue stars, the Lynx Arc must contain around a million such stars! Furthermore, the spectrum shows that the stars in the Lynx Arc are more than twice as hot as the Orion Nebula's central stars, with surface temperatures up to 80 000°C. Though there are much bigger and brighter star-forming regions than the Orion Nebula in our local Universe, none are as bright as the Lynx Arc, nor do they contain such large numbers of hot stars. Even the most massive, normal nearby stars are no hotter than around 40 000°C. However, stars forming from the original, pristine gas in the early Universe can be more massive and consequently much hotter - perhaps up to 120 000°C. The earliest stars may have been as much as several hundred solar masses, but the chemical make-up of the Universe today prevents stars from forming beyond about 100 solar masses. Such 'primordial' super-hot stars are thought to be the first luminous objects to condense after the Big Bang cooled. Astronomers believe that these first 'monster' stars formed considerably earlier than the Lynx Arc - up to 1800 million years earlier. "This remarkable object is the closest we have come so far to seeing what such primordial objects might look like when our telescopes become powerful enough to see them," says Fosbury. The desire to find and study the first luminous objects in the Universe is the main scientific drive behind the construction of the NASA/ESA/CSA James Webb Space Telescope, scheduled for launch in 2011. Notes for editors The team is composed of R. A. E. Fosbury (European Space Agency/Space Telescope-European Coordinating Facility, Germany), M. Villar-Martín and A. Humphrey (University of Hertfordshire, UK), M. Lombardi and P. Rosati (European Southern Observatory, Germany), D. Stern (Institute of Geophysics and Planetary Physics, USA), R. N. Hook (ST-ECF/STScI, USA), B. P. Holden and S. A. Stanford (University of California, USA), G. K. Squires (SIRTF Science Center, USA), M. Rauch (The Observatories of the Carnegie Institution of Washington, USA) and W. L. W. Sargent (California Institute of Technology, USA). For broadcasters, animations of the discovery, interviews and general Hubble Space Telescope background footage are available from the ESA Television Service, see http://television.esa.int, and from http://www.spacetelescope.org/video/heic0312_vnr.html

  8. The Biggest Stick: The Employment of Artillery Units in Counterinsurgency

    2011-06-10

    83 59Riley Sunderland, Organizing Counterinsurgency in Malaya, 1947-1960 (Santa Monica, CA: RAND, 1964), 17. 60The Virgin Soldiers, ―British...on the night of 30-31 January 1968 in the midst of the largest holiday on the Vietnamese calendar, and it culminated within two weeks except in Hue...executed bodies per month to a pacified environment in which locals brought American soldiers food on holidays .191 The glaring negative effect was

  9. Smashing physics. Inside the world's biggest experiment

    Butterworth, Jon

    2015-01-01

    The discovery of the Higgs boson made headlines around the world. Two scientists, Peter Higgs and Francois Englert, whose theories predicted its existence, shared a Nobel Prize. The discovery was the culmination of the largest experiment ever run, the ATLAS and CMS experiments at CERN's Large Hadron Collider. But what really is a Higgs boson and what does it do? How was it found? And how has its discovery changed our understanding of the fundamental laws of nature? And what did it feel like to be part of it? Jon Butterworth is one of the leading physicists at CERN and this book is the first popular inside account of the hunt for the Higgs. It is a story of incredible scientific collaboration, inspiring technological innovation and ground-breaking science. It is also the story of what happens when the world's most expensive experiment blows up, of neutrinos that may or may not travel faster than light, and the reality of life in an underground bunker in Switzerland. This book will also leave you with a working knowledge of the new physics and what the discovery of the Higgs particle means for how we define the laws of nature. It will take you to the cutting edge of modern scientific thinking.

  10. Single-Phase PLLs

    Golestan, Saeed; Guerrero, Josep M.; Quintero, Juan Carlos Vasquez

    2017-01-01

    Single-phase phase-locked loops (PLLs) are popular for the synchronization and control of single-phase gridconnected converters. They are also widely used for monitoring and diagnostic purposes in the power and energy areas. In recent years, a large number of single-phase PLLs with different stru......-PLLs). The members of each category are then described and their pros and cons are discussed. This work provides a deep insight into characteristics of different single-phase PLLs and, therefore, can be considered as a reference for researchers and engineers....

  11. Single ventricle cardiac defect

    Eren, B.; Turkmen, N.; Fedakar, R.; Cetin, V.

    2010-01-01

    Single ventricle heart is defined as a rare cardiac abnormality with a single ventricle chamber involving diverse functional and physiological defects. Our case is of a ten month-old baby boy who died shortly after admission to the hospital due to vomiting and diarrhoea. Autopsy findings revealed cyanosis of finger nails and ears. Internal examination revealed; large heart, weighing 60 grams, single ventricle, without a septum and upper membranous part. Single ventricle is a rare pathology, hence, this paper aims to discuss this case from a medico-legal point of view. (author)

  12. Single photon emission tomography

    Buvat, Irene

    2011-09-01

    The objective of this lecture is to present the single photon emission computed tomography (SPECT) imaging technique. Content: 1 - Introduction: anatomic, functional and molecular imaging; Principle and role of functional or molecular imaging; 2 - Radiotracers: chemical and physical constraints, main emitters, radioisotopes production, emitters type and imaging techniques; 3 - Single photon emission computed tomography: gamma cameras and their components, gamma camera specifications, planar single photon imaging characteristics, gamma camera and tomography; 4 - Quantification in single photon emission tomography: attenuation, scattering, un-stationary spatial resolution, partial volume effect, movements, others; 5 - Synthesis and conclusion

  13. Sensing single electrons with single molecules

    Plakhotnik, Taras

    2007-01-01

    We propose a new methodology for probing transport of just one electron, a process of great importance both in nature and in artificial devices. Our idea for locating a single electron is analogues to the conventional GPS where signals from several satellites are used to locate a macro object. Using fluorescent molecules as tiny sensors, it is possible to determine 3D displacement vector of an electron

  14. Power profiles of single vision and multifocal soft contact lenses.

    Wagner, Sandra; Conrad, Fabian; Bakaraju, Ravi C; Fedtke, Cathleen; Ehrmann, Klaus; Holden, Brien A

    2015-02-01

    The purpose of this study was to investigate the optical zone power profile of the most commonly prescribed soft contact lenses to assess their potential impact on peripheral refractive error and hence myopia progression. The optical power profiles of six single vision and ten multifocal contact lenses of five manufacturers in the powers -1.00 D, -3.00 D, and -6.00 D were measured using the SHSOphthalmic (Optocraft GmbH, Erlangen, Germany). Instrument repeatability was also investigated. Instrument repeatability was dependent on the distance from the optical centre, manifesting unreliable data for the central 1mm of the optic zone. Single vision contact lens measurements of -6.00 D lenses revealed omafilcon A having the most negative spherical aberration, lotrafilcon A having the least. Somofilcon A had the highest minus power and lotrafilcon A the biggest deviation in positive direction, relative to their respective labelled powers. Negative spherical aberration occurred for almost all of the multifocal contact lenses, including the centre-distance designs etafilcon A bifocal and omafilcon A multifocal. Lotrafilcon B and balafilcon A seem to rely predominantly on the spherical aberration component to provide multifocality. Power profiles of single vision soft contact lenses varied greatly, many having a negative spherical aberration profile that would exacerbate myopia. Some lens types and powers are affected by large intra-batch variability or power offsets of more than 0.25 dioptres. Evaluation of power profiles of multifocal lenses was derived that provides helpful information for prescribing lenses for presbyopes and progressing myopes. Copyright © 2014 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.

  15. Single-sided NMR

    Casanova, Federico; Blümich, Bernhard

    2011-01-01

    Single-Sided NMR describes the design of the first functioning single-sided tomograph, the related measurement methods, and a number of applications. One of the key advantages to this method is the speed at which the images are obtained.

  16. Understanding Single Adulthood.

    Stein, Peter J.

    The life styles and life chances of the unmarried include elements of choices. Singles may be grouped and characterized according to whether their status may be considered stable or temporary. A life cycle, or continuum model of singlehood is reviewed, including its different factors, or phases. A new model for singles is proposed--a life spiral…

  17. Single gaze gestures

    Møllenbach, Emilie; Lilholm, Martin; Gail, Alastair

    2010-01-01

    This paper examines gaze gestures and their applicability as a generic selection method for gaze-only controlled interfaces. The method explored here is the Single Gaze Gesture (SGG), i.e. gestures consisting of a single point-to-point eye movement. Horizontal and vertical, long and short SGGs were...

  18. Single molecules and nanotechnology

    Vogel, Horst

    2007-01-01

    This book focuses on recent advances in the rapidly evolving field of single molecule research. These advances are of importance for the investigation of biopolymers and cellular biochemical reactions, and are essential to the development of quantitative biology. Written by leading experts in the field, the articles cover a broad range of topics, including: quantum photonics of organic dyes and inorganic nanoparticles their use in detecting properties of single molecules the monitoring of single molecule (enzymatic) reactions single protein (un)folding in nanometer-sized confined volumes the dynamics of molecular interactions in biological cells The book is written for advanced students and scientists who wish to survey the concepts, techniques and results of single molecule research and assess them for their own scientific activities.

  19. Single-photon imaging

    Seitz, Peter

    2011-01-01

    The acquisition and interpretation of images is a central capability in almost all scientific and technological domains. In particular, the acquisition of electromagnetic radiation, in the form of visible light, UV, infrared, X-ray, etc. is of enormous practical importance. The ultimate sensitivity in electronic imaging is the detection of individual photons. With this book, the first comprehensive review of all aspects of single-photon electronic imaging has been created. Topics include theoretical basics, semiconductor fabrication, single-photon detection principles, imager design and applications of different spectral domains. Today, the solid-state fabrication capabilities for several types of image sensors has advanced to a point, where uncoooled single-photon electronic imaging will soon become a consumer product. This book is giving a specialist´s view from different domains to the forthcoming “single-photon imaging” revolution. The various aspects of single-photon imaging are treated by internati...

  20. Single Nanoparticle Plasmonic Sensors

    Manish Sriram

    2015-10-01

    Full Text Available The adoption of plasmonic nanomaterials in optical sensors, coupled with the advances in detection techniques, has opened the way for biosensing with single plasmonic particles. Single nanoparticle sensors offer the potential to analyse biochemical interactions at a single-molecule level, thereby allowing us to capture even more information than ensemble measurements. We introduce the concepts behind single nanoparticle sensing and how the localised surface plasmon resonances of these nanoparticles are dependent upon their materials, shape and size. Then we outline the different synthetic approaches, like citrate reduction, seed-mediated and seedless growth, that enable the synthesis of gold and silver nanospheres, nanorods, nanostars, nanoprisms and other nanostructures with tunable sizes. Further, we go into the aspects related to purification and functionalisation of nanoparticles, prior to the fabrication of sensing surfaces. Finally, the recent developments in single nanoparticle detection, spectroscopy and sensing applications are discussed.

  1. Single Policy Study

    Kronsell, Annica; Manners, Ian James

    2015-01-01

    Single policy studies are the most common form of European Union (EU) research. Single policy studies are widely used to understand the role of the EU in a wide variety of sectors, together with their development over time, and often offer public policy prescriptions. This chapter discusses...... the relevance of single policy studies in EU research and give examples of how such research can be designed and carried out. The chapter reviews three examples of single policy studies using different methods based on EU environmental policy, the EU biofuels directive, and the EU Common Security and Defence...... Policy (CSDP). The examples are illustrative of how single policy studies can be designed to use different approaches in the analysis: multiple streams approach to policy-making; a comparative hypothesis testing; and feminist institutional theory....

  2. A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level.

    Grünberger, Alexander; Paczia, Nicole; Probst, Christopher; Schendzielorz, Georg; Eggeling, Lothar; Noack, Stephan; Wiechert, Wolfgang; Kohlheyer, Dietrich

    2012-05-08

    In the continuously growing field of industrial biotechnology the scale-up from lab to industrial scale is still a major hurdle to develop competitive bioprocesses. During scale-up the productivity of single cells might be affected by bioreactor inhomogeneity and population heterogeneity. Currently, these complex interactions are difficult to investigate. In this report, design, fabrication and operation of a disposable picolitre cultivation system is described, in which environmental conditions can be well controlled on a short time scale and bacterial microcolony growth experiments can be observed by time-lapse microscopy. Three exemplary investigations will be discussed emphasizing the applicability and versatility of the device. Growth and analysis of industrially relevant bacteria with single cell resolution (in particular Escherichia coli and Corynebacterium glutamicum) starting from one single mother cell to densely packed cultures is demonstrated. Applying the picolitre bioreactor, 1.5-fold increased growth rates of C. glutamicum wild type cells were observed compared to typical 1 litre lab-scale batch cultivation. Moreover, the device was used to analyse and quantify the morphological changes of an industrially relevant l-lysine producer C. glutamicum after artificially inducing starvation conditions. Instead of a one week lab-scale experiment, only 1 h was sufficient to reveal the same information. Furthermore, time lapse microscopy during 24 h picolitre cultivation of an arginine producing strain containing a genetically encoded fluorescence sensor disclosed time dependent single cell productivity and growth, which was not possible with conventional methods.

  3. Development of a high frequency single-element ultrasound needle transducer for anesthesia delivery

    Ameri, Golafsoun; Son, Jungik; Liang, Jingwei; Foster, F. Stuart; Ganapathy, Sugantha; Peters, Terry M.

    2017-03-01

    Epidural anesthesia is one of the most commonly used and yet challenging techniques employed for pain management and anesthesia delivery. The major complications of this procedure are due to accidental dural puncture, with an incidence of 1-3%, which could lead to both temporary and irreversible permanent neurological complications. Needle placement under ultrasound (US) guidance has received increasing interest for improving needle placement accuracy. However, poor needle visibility in US, difficulties in displaying relevant anatomical structure such as dura mater due to attenuation and bone shadowing, and image interpretation variability among users pose significant hurdles for any US guidance system. As a result, US guidance for epidural injections has not been widely adopted for everyday use for the performance of neuraxial blocks. The difficulties in localizing the ligamentum flavum and dura with respect to the needle tip can be addressed by integrating A-mode US, provided by a single-element transducer at the needle tip, into the B-mode US guidance system. We have taken the first steps towards providing such a guidance system. Our goal is to improve the safety of this procedure with minimal changes to the clinical workflow. This work presents the design and development of a 20 MHz single-element US transducer housed at the tip of a 19 G needle hypodermic tube, which can fit inside an epidural introducer needle. In addition, the results from initial transducer characterization tests and performance evaluation of the transducer in a euthanized porcine model are provided.

  4. Clean Transfer of Large Graphene Single Crystals for High-Intactness Suspended Membranes and Liquid Cells.

    Zhang, Jincan; Lin, Li; Sun, Luzhao; Huang, Yucheng; Koh, Ai Leen; Dang, Wenhui; Yin, Jianbo; Wang, Mingzhan; Tan, Congwei; Li, Tianran; Tan, Zhenjun; Liu, Zhongfan; Peng, Hailin

    2017-07-01

    The atomically thin 2D nature of suspended graphene membranes holds promising in numerous technological applications. In particular, the outstanding transparency to electron beam endows graphene membranes great potential as a candidate for specimen support of transmission electron microscopy (TEM). However, major hurdles remain to be addressed to acquire an ultraclean, high-intactness, and defect-free suspended graphene membrane. Here, a polymer-free clean transfer of sub-centimeter-sized graphene single crystals onto TEM grids to fabricate large-area and high-quality suspended graphene membranes has been achieved. Through the control of interfacial force during the transfer, the intactness of large-area graphene membranes can be as high as 95%, prominently larger than reported values in previous works. Graphene liquid cells are readily prepared by π-π stacking two clean single-crystal graphene TEM grids, in which atomic-scale resolution imaging and temporal evolution of colloid Au nanoparticles are recorded. This facile and scalable production of clean and high-quality suspended graphene membrane is promising toward their wide applications for electron and optical microscopy. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Single-Arc IMRT?

    Bortfeld, Thomas; Webb, Steve

    2009-01-01

    The idea of delivering intensity-modulated radiation therapy (IMRT) with a multileaf collimator in a continuous dynamic mode during a single rotation of the gantry has recently gained momentum both in research and industry. In this note we investigate the potential of this Single-Arc IMRT technique at a conceptual level. We consider the original theoretical example case from Brahme et al that got the field of IMRT started. Using analytical methods, we derive deliverable intensity 'landscapes' for Single-Arc as well as standard IMRT and Tomotherapy. We find that Tomotherapy provides the greatest flexibility in shaping intensity landscapes and that it allows one to deliver IMRT in a way that comes close to the ideal case in the transverse plane. Single-Arc and standard IMRT make compromises in different areas. Only in relatively simple cases that do not require substantial intensity modulation will Single-Arc be dosimetrically comparable to Tomotherapy. Compared with standard IMRT, Single-Arc could be dosimetrically superior in certain cases if one is willing to accept the spreading of low dose values over large volumes of normal tissue. In terms of treatment planning, Single-Arc poses a more challenging optimization problem than Tomotherapy or standard IMRT. We conclude that Single-Arc holds potential as an efficient IMRT technique especially for relatively simple cases. In very complex cases, Single-Arc may unduly compromise the quality of the dose distribution, if one tries to keep the treatment time below 2 min or so. As with all IMRT techniques, it is important to explore the tradeoff between plan quality and the efficiency of its delivery carefully for each individual case. (note)

  6. Single neuron computation

    McKenna, Thomas M; Zornetzer, Steven F

    1992-01-01

    This book contains twenty-two original contributions that provide a comprehensive overview of computational approaches to understanding a single neuron structure. The focus on cellular-level processes is twofold. From a computational neuroscience perspective, a thorough understanding of the information processing performed by single neurons leads to an understanding of circuit- and systems-level activity. From the standpoint of artificial neural networks (ANNs), a single real neuron is as complex an operational unit as an entire ANN, and formalizing the complex computations performed by real n

  7. Single photon ECT

    Maeda, Toshio; Matsuda, Hiroshi; Tada, Akira; Bunko, Hisashi; Koizumi, Kiyoshi

    1982-01-01

    The detectability of lesions located deep in a body or overlapped with a physiologically increased activity improve with the help of single photon ECT. In some cases, the ECT is superior to the conventional gamma camera images and X-ray CT scans in the evaluation of the location and size of lesion. The single photon ECT of the brain compares favorably with the contrast enhansed X-ray CT scans. The most important adaptation of the single photon ECT are the detection of recurrent brain tumors after craniotomy and the evaluation of ischemic heart diseases. (author)

  8. Single Electron Tunneling

    Ruggiero, Steven T.

    2005-01-01

    Financial support for this project has led to advances in the science of single-electron phenomena. Our group reported the first observation of the so-called ''Coulomb Staircase'', which was produced by tunneling into ultra-small metal particles. This work showed well-defined tunneling voltage steps of width e/C and height e/RC, demonstrating tunneling quantized on the single-electron level. This work was published in a now well-cited Physical Review Letter. Single-electron physics is now a major sub-field of condensed-matter physics, and fundamental work in the area continues to be conducted by tunneling in ultra-small metal particles. In addition, there are now single-electron transistors that add a controlling gate to modulate the charge on ultra-small photolithographically defined capacitive elements. Single-electron transistors are now at the heart of at least one experimental quantum-computer element, and single-electron transistor pumps may soon be used to define fundamental quantities such as the farad (capacitance) and the ampere (current). Novel computer technology based on single-electron quantum dots is also being developed. In related work, our group played the leading role in the explanation of experimental results observed during the initial phases of tunneling experiments with the high-temperature superconductors. When so-called ''multiple-gap'' tunneling was reported, the phenomenon was correctly identified by our group as single-electron tunneling in small grains in the material. The main focus throughout this project has been to explore single electron phenomena both in traditional tunneling formats of the type metal/insulator/particles/insulator/metal and using scanning tunneling microscopy to probe few-particle systems. This has been done under varying conditions of temperature, applied magnetic field, and with different materials systems. These have included metals, semi-metals, and superconductors. Amongst a number of results, we have

  9. Aplicação de revestimento comestível em abacaxis processados por métodos combinados: isoterma de sorção e cinética de desidratação osmótica Application of edible coatings in processed pineapples products by hurdle technology: desorption isotherms and kinetics of the osmotic dehydration

    Renata Paula Herrera Brandelero

    2005-06-01

    Full Text Available A desidratação osmótica é uma etapa essencial na elaboração de produtos de fruta através da Tecnologia dos Métodos Combinados ou de Obstáculos ("Hurdle Technology", pois reduz a atividade de água para níveis que, combinando um ou mais obstáculos, aumentam a estabilidade do produto. Neste processo há uma perda de água da fruta para a solução e incorporação de sólidos solúveis pelo produto. Este último fluxo é considerado uma desvantagem do processo pois pode alterar o sabor do produto. Neste trabalho estudou-se a ação de revestimentos comestíveis a base de alginato e gelatina aplicados em abacaxis, previamente à desidratação osmótica, como barreira à incorporação de sólidos solúveis. Os abacaxis com e sem revestimento (controle foram desidratados em solução de sacarose sob condições isotérmicas. Foram determinadas as isotermas de dessorção de abacaxis revestidos com gelatina, alginato e sem revestimento e os parâmetros cinéticos do processo de desidratação osmótica. Abacaxis revestidos com alginato apresentaram menor velocidade de ganho de sólidos, sem alterar a velocidade de perda de água, quando comparado ao controle.The osmotic dehydration is an essential stage to manufacture fruit products by Hurdle Technology because it reduces the water activity to levels that, combined with one or more obstacles, increase the stability of the product. This process causes a loss of water from the fruit to solution and soluble solid incorporation by the product. This last flow is considered a disadvantage of the process because it can modify the product flavor. In this work, the action of alginate and gelatin edible coatings as a barrier to soluble solid incorporation during osmotic dehydration was studied. Pineapples with and without coating (control were dehydrated in sucrose solution under isothermal conditions. The desorption isotherms of pineapples coated with gelatin, sodium alginate and without coating

  10. A Single Atom Antenna

    Trinter, Florian; Williams, Joshua B; Weller, Miriam; Waitz, Markus; Pitzer, Martin; Voigtsberger, Jörg; Schober, Carl; Kastirke, Gregor; Müller, Christian; Goihl, Christoph; Burzynski, Phillip; Wiegandt, Florian; Wallauer, Robert; Kalinin, Anton; Schmidt, Lothar Ph H; Schöffler, Markus S; Jahnke, Till; Dörner, Reinhard; Chiang, Ying-Chih; Gokhberg, Kirill

    2015-01-01

    Here we demonstrate the smallest possible implementation of an antenna-receiver complex which consists of a single (helium) atom acting as the antenna and a second (neon) atom acting as a receiver. (paper)

  11. Single Beam Holography.

    Chen, Hsuan; Ruterbusch, Paul H.

    1979-01-01

    Discusses how holography can be used as part of undergraduate physics laboratories. The authors propose a single beam technique of holography, which will reduce the recording scheme as well as relax the isolation requirements. (HM)

  12. Single-photon sources

    Lounis, Brahim; Orrit, Michel

    2005-01-01

    The concept of the photon, central to Einstein's explanation of the photoelectric effect, is exactly 100 years old. Yet, while photons have been detected individually for more than 50 years, devices producing individual photons on demand have only appeared in the last few years. New concepts for single-photon sources, or 'photon guns', have originated from recent progress in the optical detection, characterization and manipulation of single quantum objects. Single emitters usually deliver photons one at a time. This so-called antibunching of emitted photons can arise from various mechanisms, but ensures that the probability of obtaining two or more photons at the same time remains negligible. We briefly recall basic concepts in quantum optics and discuss potential applications of single-photon states to optical processing of quantum information: cryptography, computing and communication. A photon gun's properties are significantly improved by coupling it to a resonant cavity mode, either in the Purcell or strong-coupling regimes. We briefly recall early production of single photons with atomic beams, and the operation principles of macroscopic parametric sources, which are used in an overwhelming majority of quantum-optical experiments. We then review the photophysical and spectroscopic properties and compare the advantages and weaknesses of various single nanometre-scale objects used as single-photon sources: atoms or ions in the gas phase and, in condensed matter, organic molecules, defect centres, semiconductor nanocrystals and heterostructures. As new generations of sources are developed, coupling to cavities and nano-fabrication techniques lead to improved characteristics, delivery rates and spectral ranges. Judging from the brisk pace of recent progress, we expect single photons to soon proceed from demonstrations to applications and to bring with them the first practical uses of quantum information

  13. Single particle dynamics

    Siemens, P.J.; Jensen, A.S.

    1985-01-01

    It is shown that the opening of the 3-quasiparticle continuum at 3Δ sets the energy scale for the enhancement of the effective mass near the Fermi surface of nuclei. The authors argue that the spreading width of single-particle states due to coupling with low-lying collective modes is qualitatively different from the two-body collision mechanism, and contributes little to the single-particle lifetime in the sense of the optical model. (orig.)

  14. Characteristics between the meshing pairs with different envelope profile in single screw compressors

    Huang, R.; Liu, F.; Li, T.; Feng, Q.

    2017-08-01

    Single screw compressors have been used in various industrial fields. However, because the star-wheel teeth are easy to wear, the market for the development of single screw compressors is limited. In order to extend the service life of the star-wheel, researchers have developed different kinds of star-wheel tooth profile, such as single line envelope profile, single column envelope profile, and multi-column envelope profile. These profiles greatly affect the lubrication characteristics between the star-wheel teeth and the screw grooves. In this article, the lubrication characteristics between the meshing pairs with different envelope profiles are analyzed. Results show that the pressure peak of the single line envelope profile, single column envelope profile, and multi-column envelope profile are 3.23×105Pa, 3.38×105Pa, and 4.31×105Pa, respectively. This means that the multi-column enveloped meshing pair can resist the biggest external impact load. The deviation angle (γ) of the single line envelope profile, single column envelope profile, and multi-column envelope profile are 0.0139°~0.0286°, 0.0225°~0.0306° and 0.0122°~0.0262°, respectively. Thus, the self-balancing ability of the multi-column enveloped meshing pair is the strongest, and the oil film thickness on both sides of the multi-column enveloped star-wheel tooth is the most reasonable, which indicates a good lubrication state during operation, that is, longer operation life of the star-wheel teeth.

  15. Single droplet analysis for spray drying of foods

    Perdana, J.A.

    2013-01-01

    Many food ingredients, such as enzymes and probiotics, are spray dried to provide shelf-life. Major hurdle to apply spray drying is the lack of scientific insight on the inactivation mechanisms of components and the extensive optimization required for formulation and drying conditions to obtain

  16. Single-Mode VCSELs

    Larsson, Anders; Gustavsson, Johan S.

    The only active transverse mode in a truly single-mode VCSEL is the fundamental mode with a near Gaussian field distribution. A single-mode VCSEL produces a light beam of higher spectral purity, higher degree of coherence and lower divergence than a multimode VCSEL and the beam can be more precisely shaped and focused to a smaller spot. Such beam properties are required in many applications. In this chapter, after discussing applications of single-mode VCSELs, we introduce the basics of fields and modes in VCSELs and review designs implemented for single-mode emission from VCSELs in different materials and at different wavelengths. This includes VCSELs that are inherently single-mode as well as inherently multimode VCSELs where higher-order modes are suppressed by mode selective gain or loss. In each case we present the current state-of-the-art and discuss pros and cons. At the end, a specific example with experimental results is provided and, as a summary, the most promising designs based on current technologies are identified.

  17. Single-photon imaging

    Seitz, Peter; Theuwissen, Albert J.P.

    2011-01-01

    The acquisition and interpretation of images is a central capability in almost all scientific and technological domains. In particular, the acquisition of electromagnetic radiation, in the form of visible light, UV, infrared, X-ray, etc. is of enormous practical importance. The ultimate sensitivity in electronic imaging is the detection of individual photons. With this book, the first comprehensive review of all aspects of single-photon electronic imaging has been created. Topics include theoretical basics, semiconductor fabrication, single-photon detection principles, imager design and applications of different spectral domains. Today, the solid-state fabrication capabilities for several types of image sensors has advanced to a point, where uncooled single-photon electronic imaging will soon become a consumer product. This book is giving a specialist's view from different domains to the forthcoming ''single-photon imaging'' revolution. The various aspects of single-photon imaging are treated by internationally renowned, leading scientists and technologists who have all pioneered their respective fields. (orig.)

  18. Single port laparoscopic surgery

    Springborg, Henrik; Istre, Olav

    2012-01-01

    LESS, or laparo-endoscopic single site surgery, is a promising new method in minimally invasive surgery. An increasing number of surgical procedures are being performed using this technique, however, its large-scale adoption awaits results of prospective randomized controlled studies confirming...... potential benefits. Theoretically, cosmetic outcomes, postoperative pain and complication rates could be improved with use of single site surgery. This study describes introduction of the method in a private hospital in Denmark, in which 40 patients have been treated for benign gynecologic conditions....... Although the operations described are the first of their kind reported in Denmark, favorable operating times and very low complication rates are seen. It is the authors' opinion that in addition to being feasible for hysterectomy, single port laparoscopy may become the preferred method for many simple...

  19. Single Cell Oncogenesis

    Lu, Xin

    It is believed that cancer originates from a single cell that has gone through generations of evolution of genetic and epigenetic changes that associate with the hallmarks of cancer. In some cancers such as various types of leukemia, cancer is clonal. Yet in other cancers like glioblastoma (GBM), there is tremendous tumor heterogeneity that is likely to be caused by simultaneous evolution of multiple subclones within the same tissue. It is obvious that understanding how a single cell develops into a clonal tumor upon genetic alterations, at molecular and cellular levels, holds the key to the real appreciation of tumor etiology and ultimate solution for therapeutics. Surprisingly very little is known about the process of spontaneous tumorigenesis from single cells in human or vertebrate animal models. The main reason is the lack of technology to track the natural process of single cell changes from a homeostatic state to a progressively cancerous state. Recently, we developed a patented compound, photoactivatable (''caged'') tamoxifen analogue 4-OHC and associated technique called optochemogenetic switch (OCG switch), which we believe opens the opportunity to address this urgent biological as well as clinical question about cancer. We propose to combine OCG switch with genetically engineered mouse models of head and neck squamous cell carcinoma and high grade astrocytoma (including GBM) to study how single cells, when transformed through acute loss of tumor suppressor genes PTEN and TP53 and gain of oncogenic KRAS, can develop into tumor colonies with cellular and molecular heterogeneity in these tissues. The abstract is for my invited talk in session ``Beyond Darwin: Evolution in Single Cells'' 3/18/2016 11:15 AM.

  20. Single well techniques

    Drost, W.

    1983-01-01

    The single well technique method includes measurement of parameters of groundwater flow in saturated rock. For determination of filtration velocity the dilution of radioactive tracer is measured, for direction logging the collimeter is rotated in the probe linked with the compass. The limiting factor for measurement of high filtration velocities is the occurrence of turbulent flow. The single well technique is used in civil engineering projects, water works and subsurface drainage of liquid waste from disposal sites. The radioactive tracer method for logging the vertical fluid movement in bore-holes is broadly used in groundwater survey and exploitation. (author)

  1. Beware the single hit!

    2008-01-01

    The first time that single particle effects from cosmic rays on electronics were observed was in 1991, when one of the instruments aboard an ESA satellite broke down after only five days in space. On 5 July, the TS-LEA group will have completed the installation of monitors that will help to reduce similar dangerous effects on LHC electronics.

  2. Single bubble sonoluminescence

    Brenner, Michael P.; Hilgenfeldt, Sascha; Lohse, Detlef

    2002-01-01

    Single-bubble sonoluminescence occurs when an acoustically trapped and periodically driven gas bubble collapses so strongly that the energy focusing at collapse leads to light emission. Detailed experiments have demonstrated the unique properties of this system: the spectrum of the emitted light

  3. Single-Molecule Spectroscopy

    Home; Journals; Resonance – Journal of Science Education; Volume 20; Issue 2. Single-Molecule Spectroscopy: Every Molecule is Different! Kankan Bhattacharyya. General Article Volume 20 Issue 2 February 2015 pp 151-164. Fulltext. Click here to view fulltext PDF. Permanent link:

  4. Single cell metabolomics

    Heinemann, Matthias; Zenobi, Renato

    Recent discoveries suggest that cells of a clonal population often display multiple metabolic phenotypes at the same time. Motivated by the success of mass spectrometry (MS) in the investigation of population-level metabolomics, the analytical community has initiated efforts towards MS-based single

  5. Beyond the Single Story

    McKenney, Yekaterina

    2016-01-01

    Teachers of world literature have the opportunity to help students explore the more complex reality behind the stereotypes that they often see in the media. If we don't encourage students to challenge one-dimensional "single stories" that characterize an entire people--whether Muslims, Russians, Mexicans, African Americans, Chinese,…

  6. Single Value Devices

    Mader, Angelika H.; Dertien, Edwin Christian; Reidsma, Dennis

    2011-01-01

    We live in a world of continuous information overflow, but the quality of information and communication is suffering. Single value devices contribute to the information and communication quality by fo- cussing on one explicit, relevant piece of information. The information is decoupled from a

  7. Current Status of Comprehensive Chromosome Screening for Elective Single-Embryo Transfer

    Ming-Yih Wu

    2014-01-01

    Full Text Available Most in vitro fertilization (IVF experts and infertility patients agree that the most ideal assisted reproductive technology (ART outcome is to have a healthy, full-term singleton born. To this end, the most reliable policy is the single-embryo transfer (SET. However, unsatisfactory results in IVF may result from plenty of factors, in which aneuploidy associated with advanced maternal age is a major hurdle. Throughout the past few years, we have got a big leap in advancement of the genetic screening of embryos on aneuploidy, translocation, or mutations. This facilitates a higher success rate in IVF accompanied by the policy of elective SET (eSET. As the cost is lowering while the scale of genome characterization continues to be up over the recent years, the contemporary technologies on trophectoderm biopsy and freezing-thaw, comprehensive chromosome screening (CCS with eSET appear to be getting more and more popular for modern IVF centers. Furthermore, evidence has showen that, by these avant-garde techniques (trophectoderm biopsy, vitrification, and CCS, older infertile women with the help of eSET may have an opportunity to increase the success of their live birth rates approaching those reported in younger infertility patients.

  8. Single frequency semiconductor lasers

    Fang, Zujie; Chen, Gaoting; Qu, Ronghui

    2017-01-01

    This book systematically introduces the single frequency semiconductor laser, which is widely used in many vital advanced technologies, such as the laser cooling of atoms and atomic clock, high-precision measurements and spectroscopy, coherent optical communications, and advanced optical sensors. It presents both the fundamentals and characteristics of semiconductor lasers, including basic F-P structure and monolithic integrated structures; interprets laser noises and their measurements; and explains mechanisms and technologies relating to the main aspects of single frequency lasers, including external cavity lasers, frequency stabilization technologies, frequency sweeping, optical phase locked loops, and so on. It paints a clear, physical picture of related technologies and reviews new developments in the field as well. It will be a useful reference to graduate students, researchers, and engineers in the field.

  9. Single Nucleotide Polymorphism

    Børsting, Claus; Pereira, Vania; Andersen, Jeppe Dyrberg

    2014-01-01

    Single nucleotide polymorphisms (SNPs) are the most frequent DNA sequence variations in the genome. They have been studied extensively in the last decade with various purposes in mind. In this chapter, we will discuss the advantages and disadvantages of using SNPs for human identification...... of SNPs. This will allow acquisition of more information from the sample materials and open up for new possibilities as well as new challenges....

  10. Single sector supersymmetry breaking

    Luty, Markus A.; Terning, John

    1999-01-01

    We review recent work on realistic models that break supersymmetry dynamically and give rise to composite quarks and leptons, all in a single sector. These models have a completely natural suppression of flavor-changing neutral currents, and the hierarchy of Yukawa couplings is explained by the dimensionality of composite states. The generic signatures are unification of scalar masses with different quantum numbers at the compositeness scale, and lighter gaugino, Higgsino, and third-generation sfermion masses

  11. Tablet use in primary education: Adoption hurdles and attitude determinants

    van Deursen, Alexander Johannes Aloysius Maria; Ben Allouch, Soumaya; Ruijter, Laura P.

    2016-01-01

    In the Netherlands, six primary schools recently participated in a pilot program, creating an educational environment in which children use a tablet PC. In these six schools, two studies are conducted. The first study highlights the process by which primary schools adopted tablet PCs by means of

  12. Tablet Use in Primary Education: Adoption Hurdles and Attitude Determinants

    van Deursen, Alexander J. A. M.; ben Allouch, Somaya; Ruijter, Laura P.

    2016-01-01

    In the Netherlands, six primary schools recently participated in a pilot program, creating an educational environment in which children use a tablet PC. In these six schools, two studies are conducted. The first study highlights the process by which primary schools adopted tablet PCs by means of interviews based on diffusion of innovation theory.…

  13. BEACON: A Summary Framework to Overcome Potential Reimbursement Hurdles.

    Dunlop, William C N; Mullins, C Daniel; Pirk, Olaf; Goeree, Ron; Postma, Maarten J; Enstone, Ashley; Heron, Louise

    2016-10-01

    To provide a framework for addressing payers' criteria during the development of pharmaceuticals. A conceptual framework was presented to an international health economic expert panel for discussion. A structured literature search (from 2010 to May 2015), using the following databases in Ovid: Medline(®) and Medline(®) In-Process (PubMed), Embase (Ovid), EconLit (EBSCOhost) and the National Health Service Economic Evaluation Database (NHS EED), and a 'grey literature' search, were conducted to identify existing criteria from the payer perspective. The criteria assessed by existing frameworks and guidelines were collated; the most commonly reported criteria were considered for inclusion in the framework. A mnemonic was conceived as a memory aide to summarise these criteria. Overall, 41 publications were identified as potentially relevant to the objective. Following further screening, 26 were excluded upon full-text review on the basis of no framework presented (n = 13), redundancy (n = 11) or abstract only (n = 2). Frameworks that captured criteria developed for or utilised by the pharmaceutical industry (n = 5) and reimbursement guidance (n = 10) were reviewed. The most commonly identified criteria-unmet need/patient burden, safety, efficacy, quality-of-life outcomes, environment, evidence quality, budget impact and comparator-were incorporated into the summary framework. For ease of communication, the following mnemonic was developed: BEACON (Burden/target population, Environment, Affordability/value, Comparator, Outcomes, Number of studies/quality of evidence). The BEACON framework aims to capture the 'essence' of payer requirements by addressing the most commonly described criteria requested by payers regarding the introduction of a new pharmaceutical.

  14. BEACON : A Summary Framework to Overcome Potential Reimbursement Hurdles

    Dunlop, William C. N.; Mullins, C. Daniel; Pirk, Olaf; Goeree, Ron; Postma, Maarten J.; Enstone, Ashley; Heron, Louise

    2016-01-01

    Objective To provide a framework for addressing payers' criteria during the development of pharmaceuticals. Methods A conceptual framework was presented to an international health economic expert panel for discussion. A structured literature search (from 2010 to May 2015), using the following

  15. Hurdles for sport consumption? Determining factors of household sports expenditure

    Erik Thibaut; Steven Vos; Jeroen Scheerder

    2013-01-01

    The purpose of this article is to explore the determining factors of household expenditures on sports participation. Due to a relatively large amount of zero-expenditures, simple regression methods are not suited. Because of methodological reasons, the two-step Heckman approach is used over the

  16. National climate goals. Hurdle and opportunity for a climate consensus

    Bettzuege, Marc Oliver

    2018-01-01

    In the area of climate and energy policy, exploratory talks over the past few months have shown how important a common target architecture is as a compass for the coming legislative period. Three different levels can be distinguished: Paris (and thus Europe), Germany, sectors in Germany. Finding a balanced climate policy solution requires more exchange of views and less political dirigisme. In a dialogue between state and economy development paths could be spelled out together. [de

  17. Hopes & Hurdles: California Foster Youth and College Financial Aid

    Cochrane, Deborah Frankle; Szabo-Kubitz, Laura

    2009-01-01

    This report examines why former foster youth in California are not receiving the aid they are likely eligible for, from inadequate or poorly targeted information about college costs and financial aid to structural obstacles within the aid process and programs. While many of this report's findings and recommendations are specific to foster youth,…

  18. The Foundations for Learning Campaign: helping hand or hurdle ...

    One initiative taken by the Department was to launch the Foundations for Learning Campaign, a four-year national literacy and numeracy programme, in 2008. The Campaign entails amongst other things providing teachers with lesson plans and the resources needed for effective teaching and assessment. In view of the ...

  19. Overcoming Hurdles: Teaching Guides To Interpret Biodiversity Conservation.

    Kohl, Jon; Brown, Cynthia; Humke, Matt

    2001-01-01

    Highlights the development and use of bilingual nature guide training. Examines work at the RARE Center for tropical conservation in Central America. Speculates about the future of conservation interpretation. (DDR)

  20. Hurdles to Forest Friendly Farming: Sustainability Lessons from Southeastern Mexico

    Eric Keys

    2010-09-01

    Full Text Available Worldwide the search is on for sustainable solutions to the competing needs for forest conservation and agricultural development. A strategy with contemporary salience arises in intensive, sedentarized agriculture that can protect forests and enhance livelihoods for forest dwellers. This paper investigates why intensive agriculture does not limit deforestation in southeastern Mexico’s Calakmul Municipality. It argues that agriculture faces challenges from a range of biophysical and socioeconomic factors in tropical regions and that this encourages expanded land use for intensive farmers.

  1. Minimally invasive spine surgery: Hurdles to be crossed

    Mahesh Bijjawara

    2014-01-01

    Full Text Available MISS as a concept is noble and all surgeons need to address and minimize the surgical morbidity for better results. However, we need to be cautions and not fall prey into accepting that minimally invasive spine surgery can be done only when certain metal access systems are used. Minimally invasive spine surgery (MISS has come a long way since the description of endoscopic discectomy in 1997 and minimally invasive TLIF (mTLIF in 2003. Today there is credible evidence (though not level-I that MISS has comparable results to open spine surgery with the advantage of early postoperative recovery and decreased blood loss and infection rates. However, apart from decreasing the muscle trauma and decreasing the muscle dissection during multilevel open spinal instrumentation, there has been little contribution to address the other morbidity parameters like operative time , blood loss , access to decompression and atraumatic neural tissue handling with the existing MISS technologies. Since all these parameters contribute to a greater degree than posterior muscle trauma for the overall surgical morbidity, we as surgeons need to introspect before we accept the concept of minimally invasive spine surgery being reduced to surgeries performed with a few tubular retractors. A spine surgeon needs to constantly improve his skills and techniques so that he can minimize blood loss, minimize traumatic neural tissue handling and minimizing operative time without compromising on the surgical goals. These measures actually contribute far more, to decrease the morbidity than approach related muscle damage alone. Minimally invasine spine surgery , though has come a long way, needs to provide technical solutions to minimize all the morbidity parameters involved in spine surgery, before it can replace most of the open spine surgeries, as in the case of laparoscopic surgery or arthroscopic surgery.

  2. Hurdles at work: perceptions of hospital food handlers

    Sigulem Dirce

    2009-07-01

    Full Text Available Abstract Background Food handlers have a very important role in preventing food contamination during its preparation and distribution. This responsibility is even greater in hospitals, since a large number of patients have low immunity and consequently food contamination by pathogenic bacteria could be particularly harmful. Therefore, a good working environment and periodic training should be provided to food handlers by upper management. Methods This study is qualitative research by means of focus group and thematic content analysis methodologies to examine, in detail, the statements by food handlers working in the milk and specific-diet kitchens in a hospital to understand the problems they face in the workplace. Results We found that food handlers are aware of the role they play in restoring patients' health; they consider it important to offer a good-quality diet. However, according to their perceptions, a number of difficulties prevent them from reaching this aim. These include: upper management not prioritizing human and material resources to the dietetic services when making resource allocation decisions; a perception that upper management considers their work to be of lesser importance; delayed overtime payments; lack of periodic training; managers lacking administrative skills; insufficient dietitian staff assistants, leading to overwork, at the same time as there is an excess of dietitians; unhealthy environmental working conditions – high temperature, high humidity, loud and constant noise level, poor ventilation; lack of food, and kitchen utensils and equipment; and relationship conflicts with chief dieticians and co-workers. Conclusion From these findings, improvement in staff motivation could be achieved by considering non-financial incentives, such as improvement in working conditions and showing appreciation and respect through supervision, training and performance appraisal. Management action, such as investments in intermediary management so that managers have the capacity to provide supportive supervision, as well as better use of performance appraisal and access to training, may help overcome the identified problems.

  3. Kyoto protocol and its implementation in pakistan: hurdles and expectations

    Iqbal, S.; Sher, H.A.; Qureshi, S.A

    2010-01-01

    In 1997 Kyoto protocol was adopted at the third session of Conference of the parties of UNFCC in Kyoto, Japan. This protocol restricts the industrialized countries and those in transition to a market economy agreed to limit or reduce their emissions. In Pakistan the government is also taking steps to reduce the pollution. This paper discusses the possible low carbon emitting electricity generation options by keeping in view the current energy scenario of Pakistan and the new energy policy announced by the Government of Pakistan for renewable energy promotion. (author)

  4. Hurdles at work: perceptions of hospital food handlers.

    Bertin, Cilce Helena Figueiredo Preza; Rezende, Magda Andrade; Sigulem, Dirce Maria; Morais, Tania Beninga

    2009-07-24

    Food handlers have a very important role in preventing food contamination during its preparation and distribution. This responsibility is even greater in hospitals, since a large number of patients have low immunity and consequently food contamination by pathogenic bacteria could be particularly harmful. Therefore, a good working environment and periodic training should be provided to food handlers by upper management. This study is qualitative research by means of focus group and thematic content analysis methodologies to examine, in detail, the statements by food handlers working in the milk and specific-diet kitchens in a hospital to understand the problems they face in the workplace. We found that food handlers are aware of the role they play in restoring patients' health; they consider it important to offer a good-quality diet. However, according to their perceptions, a number of difficulties prevent them from reaching this aim. These include: upper management not prioritizing human and material resources to the dietetic services when making resource allocation decisions; a perception that upper management considers their work to be of lesser importance; delayed overtime payments; lack of periodic training; managers lacking administrative skills; insufficient dietitian staff assistants, leading to overwork, at the same time as there is an excess of dietitians; unhealthy environmental working conditions--high temperature, high humidity, loud and constant noise level, poor ventilation; lack of food, and kitchen utensils and equipment; and relationship conflicts with chief dieticians and co-workers. From these findings, improvement in staff motivation could be achieved by considering non-financial incentives, such as improvement in working conditions and showing appreciation and respect through supervision, training and performance appraisal. Management action, such as investments in intermediary management so that managers have the capacity to provide supportive supervision, as well as better use of performance appraisal and access to training, may help overcome the identified problems.

  5. Jumping Hurdles: Peptides Able To Overcome Biological Barriers.

    Sánchez-Navarro, Macarena; Teixidó, Meritxell; Giralt, Ernest

    2017-08-15

    The cell membrane, the gastrointestinal tract, and the blood-brain barrier (BBB) are good examples of biological barriers that define and protect cells and organs. They impose different levels of restriction, but they also share common features. For instance, they all display a high lipophilic character. For this reason, hydrophilic compounds, like peptides, proteins, or nucleic acids have long been considered as unable to bypass them. However, the discovery of cell-penetrating peptides (CPPs) opened a vast field of research. Nowadays, CPPs, homing peptides, and blood-brain barrier peptide shuttles (BBB-shuttles) are good examples of peptides able to target and to cross various biological barriers. CPPs are a group of peptides able to interact with the plasma membrane and enter the cell. They display some common characteristics like positively charged residues, mainly arginines, and amphipathicity. In this field, our group has been focused on the development of proline rich CPPs and in the analysis of the importance of secondary amphipathicity in the internalization process. Proline has a privileged structure being the only amino acid with a secondary amine and a cyclic side chain. These features constrain its structure and hamper the formation of H-bonds. Taking advantage of this privileged structure, three different families of proline-rich peptides have been developed, namely, a proline-rich dendrimer, the sweet arrow peptide (SAP), and a group of foldamers based on γ-peptides. The structure and the mechanism of internalization of all of them has been evaluated and analyzed. BBB-shuttles are peptides able to cross the BBB and to carry with them compounds that cannot reach the brain parenchyma unaided. These peptides take advantage of the natural transport mechanisms present at the BBB, which are divided in active and passive transport mechanisms. On the one hand, we have developed BBB-shuttles that cross the BBB by a passive transport mechanism, like diketoperazines (DKPs), (N-MePhe) n , or (PhPro) n . On the other hand, we have investigated BBB-shuttles that utilize active transport mechanisms such as SGV, THRre, or MiniAp-4. For the development of both groups, we have explored several approaches, such as the use of peptide libraries, both chemical and phage display, or hit-to-lead optimization processes. In this Account, we describe, in chronologic order, our contribution to the development of peptides able to overcome various biological barriers and our efforts to understand the mechanisms that they display. In addition, the potential use of both CPPs and BBB-shuttles to improve the transport of promising therapeutic compounds is described.

  6. AFRICOM: An Effective Organization or a Military Hurdle?

    2010-12-01

    different departments work in cooperation. Organization differentiation is “the differences in cognitive and emotional orientations among managers in...such as reproduction at young ages (age at marriages is early); lack of birth control or limited use of contraceptives ; high demand for children due

  7. Crossing the Hurdle: Survival Strategies of Poor Women in Addis ...

    Eastern Africa Social Science Research Review. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 24, No 1 (2008) >. Log in or Register to get access to full text downloads.

  8. Formative assessment in undergraduate medical education: concept, implementation and hurdles.

    Rauf, Ayesha; Shamim, Muhammad Shahid; Aly, Syed Moyn; Chundrigar, Tariq; Alam, Shams Nadeem

    2014-01-01

    Formative assessment, described as "the process of appraising, judging or evaluating students' work or performance and using this to shape and improve students' competence", is generally missing from medical schools of Pakistan. Progressive institutions conduct "formative assessment" as a fleeting part of the curriculum by using various methods that may or may not include feedback to learners. The most important factor in the success of formative assessment is the quality of feedback, shown to have the maximum impact on student accomplishment. Inclusion of formative assessment into the curriculum and its implementation will require the following: Enabling Environment, Faculty and student Training, Role of Department of Medical Education (DME). Many issues can be predicted that may jeopardize the effectiveness of formative assessment including faculty resistance, lack of motivation from students and faculty and paucity of commitment from the top administration. For improvement in medical education in Pakistan, we need to develop a system considered worthy by national and international standards. This paper will give an overview of formative assessment, its implications and recommendations for implementation in medical institutes of Pakistan.

  9. Identification of Lean Implementation Hurdles in Indian Industries

    Bhim Singh

    2016-01-01

    Due to increased pressure from global competitors, manufacturing organizations are switching over to lean philosophies from traditional mass production. Lean manufacturing is a manufacturing philosophy which focuses on elimination of various types of wastes and creates maximum value for the end customers. Lean thinking aims to produce high quality products and services at the lowest possible cost with maximum customer responsiveness. Indian Industry is facing lot of problems in this transform...

  10. Microfluidics for biological analysis: Triumphs and hurdles of CD ...

    Finally, an overview of the challenges ... with solutions and a forward-looking description of a system that can be used both in and ... Finally, challenges and solutions ..... discuss in detail how these methods work, but ..... forms, and is a result of the balance between cen- ..... laboratory (e.g., shelf-life for a commercial product.

  11. Hurdles to regulatory reform: a former regulator's view

    Rowden, M.A.

    1978-01-01

    The present paper reviews the numerous obstacles which should be overcome by reforming the regulations on nuclear installations; dual responsibilities of Federal and State Agencies, duplication of tasks entrusted to different Federal Agencies such as EPA and NRC. The sensitivity of public opinion towards nuclear decisions and political interferences are the source of other difficulties. The new Non-proliferation Act and the Licensing Reform Bill are analysed in the light of these considerations. In conclusion, the importance of the recent Supreme Court decision in the Vermont Yankee and Midland cases is emphasized in this context. (NEA) [fr

  12. Hurdles to clinical translation of human induced pluripotent stem cells

    Neofytou, Evgenios; O’Brien, Connor Galen; Couture, Larry A.; Wu, Joseph C.

    2015-01-01

    Human pluripotent stem cells are known to have the capacity to renew indefinitely, being intrinsically able to differentiate into many different cell types. These characteristics have generated tremendous enthusiasm about the potential applications of these cells in regenerative medicine. However, major challenges remain with the development and testing of novel experimental stem cell therapeutics in the field. In this Review, we focus on the nature of the preclinical challenges and discuss p...

  13. Hurdles to clinical translation of human induced pluripotent stem cells.

    Neofytou, Evgenios; O'Brien, Connor Galen; Couture, Larry A; Wu, Joseph C

    2015-07-01

    Human pluripotent stem cells are known to have the capacity to renew indefinitely, being intrinsically able to differentiate into many different cell types. These characteristics have generated tremendous enthusiasm about the potential applications of these cells in regenerative medicine. However, major challenges remain with the development and testing of novel experimental stem cell therapeutics in the field. In this Review, we focus on the nature of the preclinical challenges and discuss potential solutions that could help overcome them. Furthermore, we discuss the use of allogeneic versus autologous stem cell products, including a review of their respective advantages and disadvantages, major clinical requirements, quality standards, time lines, and costs of clinical grade development.

  14. Uniform Single Valued Neutrosophic Graphs

    S. Broumi

    2017-09-01

    Full Text Available In this paper, we propose a new concept named the uniform single valued neutrosophic graph. An illustrative example and some properties are examined. Next, we develop an algorithmic approach for computing the complement of the single valued neutrosophic graph. A numerical example is demonstrated for computing the complement of single valued neutrosophic graphs and uniform single valued neutrosophic graph.

  15. Single Electrode Heat Effects

    Jacobsen, Torben; Broers, G. H. J.

    1977-01-01

    The heat evolution at a single irreversibly working electrode is treated onthe basis of the Brønsted heat principle. The resulting equation is analogous to the expression for the total heat evolution in a galvanic cellwith the exception that –DeltaS is substituted by the Peltier entropy, Delta......SP, of theelectrode reaction. eta is the overvoltage at the electrode. This equation is appliedto a high temperature carbonate fuel cell. It is shown that the Peltier entropyterm by far exceeds the heat production due to the irreversible losses, and thatthe main part of heat evolved at the cathode is reabsorbed...

  16. Single-borehole techniques

    Klotz, D.; Moser, H.; Trimborn, P.

    1978-01-01

    Proceeding on the theoretical considerations and on the experience and practice derived from laboratory and field testing, a system consisting of tracer injection units, detector units, measuring probe units and packers is presented, from which the different borehole probes required can be combined. A couple of examples of recent applications shows the position of the Single-Borehole Techniques with respect to the traditional methods used for the measurement of the ground-water flow. A confrontation of the permeabilities of different aquifers consents, both on the basis of the Single-Borehole Techniques as by pumping experiments, the determination of the reliability of the Point-Dilution-Method. The Point-Dilution-Method is giving information about the vertical and horizontal distribution of the permeabilities in an aquifer. By measuring the vertical current in two karst wells, the tributary horizons of a well have been determined, which gave valuable information for the subsequent well construction. Local leakages could be detected by measuring the vertical flow rate through observation wells arranged along a grout curtain erected on both sides of the retaining barrage of the Keban dam. (orig.) [de

  17. Single photons on demand

    Grangier, P.; Abram, I.

    2004-01-01

    Quantum cryptography and information processing are set to benefit from developments in novel light sources that can emit photons one by one. Quantum mechanics has gained a reputation for making counter-intuitive predictions. But we rarely get the chance to witness these effects directly because, being humans, we are simply too big. Take light, for example. The light sources that are familiar to us, such as those used in lighting and imaging or in CD and DVD players, are so huge that they emit billions and billions of photons. But what if there was a light source that emitted just one photon at a time? Over the past few years, new types of light source that are able to emit photons one by one have been emerging from laboratories around the world. Pulses of light composed of a single photon correspond to power flows in the femtowatt range - a million billion times less than that of a table lamp. The driving force behind the development of these single-photon sources is a range of novel applications that take advantage of the quantum nature of light. Quantum states of superposed and entangled photons could lead the way to guaranteed-secure communication, to information processing with unprecedented speed and efficiency, and to new schemes for quantum teleportation. (U.K.)

  18. Single snapshot DOA estimation

    Häcker, P.; Yang, B.

    2010-10-01

    In array signal processing, direction of arrival (DOA) estimation has been studied for decades. Many algorithms have been proposed and their performance has been studied thoroughly. Yet, most of these works are focused on the asymptotic case of a large number of snapshots. In automotive radar applications like driver assistance systems, however, only a small number of snapshots of the radar sensor array or, in the worst case, a single snapshot is available for DOA estimation. In this paper, we investigate and compare different DOA estimators with respect to their single snapshot performance. The main focus is on the estimation accuracy and the angular resolution in multi-target scenarios including difficult situations like correlated targets and large target power differences. We will show that some algorithms lose their ability to resolve targets or do not work properly at all. Other sophisticated algorithms do not show a superior performance as expected. It turns out that the deterministic maximum likelihood estimator is a good choice under these hard conditions.

  19. 75 FR 9247 - Single Family Mortgage Insurance Premium, Single Family

    2010-03-01

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5376-N-13] Single Family Mortgage Insurance Premium, Single Family AGENCY: Office of the Chief Information Officer, HUD. ACTION: Notice... is soliciting public comments on the subject proposal. Lenders use the Single Family Premium...

  20. Lanthanide single molecule magnets

    Tang, Jinkui; Zhang, Peng [Chinese Academy of Sciences, Changchun (China). Changchun Inst. of Applied Chemistry

    2015-10-01

    This book begins by providing basic information on single-molecule magnets (SMMs), covering the magnetism of lanthanide, the characterization and relaxation dynamics of SMMs and advanced means of studying lanthanide SMMs. It then systematically introduces lanthanide SMMs ranging from mononuclear and dinuclear to polynuclear complexes, classifying them and highlighting those SMMs with high barrier and blocking temperatures - an approach that provides some very valuable indicators for the structural features needed to optimize the contribution of an Ising type spin to a molecular magnet. The final chapter presents some of the newest developments in the lanthanide SMM field, such as the design of multifunctional and stimuli-responsive magnetic materials as well as the anchoring and organization of the SMMs on surfaces. In addition, the crystal structure and magnetic data are clearly presented with a wealth of illustrations in each chapter, helping newcomers and experts alike to better grasp ongoing trends and explore new directions.

  1. Lanthanide single molecule magnets

    Tang, Jinkui

    2015-01-01

    This book begins by providing basic information on single-molecule magnets (SMMs), covering the magnetism of lanthanide, the characterization and relaxation dynamics of SMMs, and advanced means of studying lanthanide SMMs. It then systematically introduces lanthanide SMMs ranging from mononuclear and dinuclear to polynuclear complexes, classifying them and highlighting those SMMs with high barrier and blocking temperatures – an approach that provides some very valuable indicators for the structural features needed to optimize the contribution of an Ising type spin to a molecular magnet. The final chapter presents some of the newest developments in the lanthanide SMM field, such as the design of multifunctional and stimuli-responsive magnetic materials as well as the anchoring and organization of the SMMs on surfaces. In addition, the crystal structure and magnetic data are clearly presented with a wealth of illustrations in each chapter, helping newcomers and experts alike to better grasp ongoing trends and...

  2. Single access laparoscopic nephrectomy

    Jay D Raman

    2008-01-01

    Full Text Available Laparoscopic nephrectomy has assumed a central role in the management of benign and malignant kidney diseases. While laparoscopy is less morbid than open surgery, it still requires several incisions each at least 1-2 cm in length. Each incision carries morbidity risks of bleeding, hernia and/or internal organ damage, and incrementally decreases cosmesis. An alternative to conventional laparoscopy is single access or keyhole surgery, which utilizes magnetic anchoring and guidance system (MAGS technology or articulating laparoscopic instruments. These technical innovations obviate the need to externally space trocars for triangulation, thus allowing for the creation of a small, solitary portal of entry into the abdomen. Laboratory and early clinical series demonstrate feasibility as well as safe and successful completion of keyhole nephrectomy. Future work is necessary to improve existing instrumentation, increase clinical experience, assess benefits of this surgical approach, and explore other potential applications for this technique.

  3. Single-Molecule Nanomagnets

    Friedman, Jonathan R.; Sarachik, Myriam P.

    2010-04-01

    Single-molecule magnets straddle the classical and quantum mechanical worlds, displaying many fascinating phenomena. They may have important technological applications in information storage and quantum computation. We review the physical properties of two prototypical molecular nanomagnets, Mn12-acetate and Fe8: Each behaves as a rigid, spin-10 object and exhibits tunneling between up and down directions. As temperature is lowered, the spin-reversal process evolves from thermal activation to pure quantum tunneling. At low temperatures, magnetic avalanches occur in which the magnetization of an entire sample rapidly reverses. We discuss the important role that symmetry-breaking fields play in driving tunneling and in producing Berry-phase interference. Recent experimental advances indicate that quantum coherence can be maintained on timescales sufficient to allow a meaningful number of quantum computing operations to be performed. Efforts are under way to create monolayers and to address and manipulate individual molecules.

  4. Regular Single Valued Neutrosophic Hypergraphs

    Muhammad Aslam Malik

    2016-12-01

    Full Text Available In this paper, we define the regular and totally regular single valued neutrosophic hypergraphs, and discuss the order and size along with properties of regular and totally regular single valued neutrosophic hypergraphs. We also extend work on completeness of single valued neutrosophic hypergraphs.

  5. Single particle detecting telescope system

    Yamamoto, I.; Tomiyama, T.; Iga, Y.; Komatsubara, T.; Kanada, M.; Yamashita, Y.; Wada, T.; Furukawa, S.

    1981-01-01

    We constructed the single particle detecting telescope system for detecting a fractionally charged particle. The telescope consists of position detecting counters, wall-less multi-cell chambers, single detecting circuits and microcomputer system as data I/0 processor. Especially, a frequency of double particle is compared the case of the single particle detecting with the case of an ordinary measurement

  6. Single atom spintronics

    Sullivan, M. R.; Armstrong, J. N.; Hua, S. Z.; Chopra, H. D.

    2005-01-01

    Full text: Single atom spintronics (SASS) represents the ultimate physical limit in device miniaturization. SASS is characterized by ballistic electron transport, and is a fertile ground for exploring new phenomena. In addition to the 'stationary' (field independent) scattering centers that have a small and fixed contribution to total transmission probability of electron waves, domain walls constitute an additional and enhanced source of scattering in these magnetic quantum point contacts (QPCs), the latter being both field and spin-dependent. Through the measurement of complete hysteresis loops as a function of quantized conductance, we present definitive evidence of enhanced backscattering of electron waves by atomically sharp domain walls in QPCs formed between microfabricated thin films [1]. Since domain walls move in a magnetic field, the magnitude of spin-dependent scattering changes as the QPC is cycled along its hysteresis loop. For example, as shown in the inset in Fig. 1, from zero towards saturation in a given field direction, the resistance varies as the wall is being swept away, whereas the resistance is constant upon returning from saturation towards zero, since in this segment of the hysteresis loop no domain wall is present across the contact. The observed spin-valve like behavior is realized by control over wall width and shape anisotropy. This behavior also unmistakably sets itself apart from any mechanical artifacts; additionally, measurements made on single atom contacts provide an artifact-free environment [2]. Intuitively, it is simpler to organize the observed BMR data according to all possible transitions between different conductance plateaus, as shown by the dotted line in Fig. 1; the solid circles show experimental data for Co, which follows the predicted scheme. Requisite elements for the observation of the effect will be discussed in detail along with a review of state of research in this field. Practically, the challenge lies in making

  7. A single particle energies

    Bodmer, A.R. [Illinois Univ., Chicago, IL (United States). Dept. of Physics]|[Argonne National Lab., IL (United States); Usmani, Q.N.; Sami, M. [Jamia Millia Islamia, New Delhi (India). Dept. of Physics

    1993-09-01

    We consider the binding energies of {Lambda} hypernuclei (HN), in particular the single-particle (s.p.) energy data, which have been obtained for a wide range of HN with mass numbers A {le} 89 and for orbital angular momenta {ell}{sub {Lambda}} {le} 4. We briefly review some of the relevant properties of A hypernuclei. These are nuclei {sub {Lambda}}{sup A}Z with baryon number A in which a single {Lambda} hyperon (baryon number = 1) is bound to an ordinary nucleus {sup A}Z consisting of A - 1 nucleons = Z protons + N neutrons. The {Lambda} hyperon is neutral, has spin 1/2, strangeness S = {minus}1, isospin I = O and a mass M{sub {Lambda}} = 1116 MeV/c{sup 2}. Although the {Lambda} interacts with a nucleon, its interaction is only about half as strong as that between two nucleons, and thus very roughly V{sub {Lambda}N} {approx} 0.5 V{sub NN}. As a result, the two-body {Lambda}N system is unbound, and the lightest bound HN is the three-body hypertriton {sub {Lambda}}{sup 3}H in which the {Lambda} is bound to a deuteron with the {Lambda}-d separation energy being only {approx} 0.1 MeV corresponding to an exponential tail of radius {approx} 15 fm! In strong interactions the strangeness S is of course conserved, and the {Lambda} is distinct from the nucleons. In a HN strangeness changes only in the weak decays of the {Lambda} which can decay either via ``free`` pionic decay {Lambda} {yields} N + {pi} or via induced decay {Lambda} + N {yields} N + N which is only possible in the presence of nucleons. Because of the small energy release the pionic decay is strongly suppressed in all but the lightest HN and the induced decay dominates. However, the weak decay lifetime {approx} 10{sup {minus}10}s is in fact close to the lifetime of a free {Lambda}. Since this is much longer than the strong interaction time {approx} 10{sup {minus}22}s we can ignore the weak interactions when considering the binding of HN, just as for ordinary nuclei.

  8. A single particle energies

    Bodmer, A.R.; Usmani, Q.N.; Sami, M.

    1993-01-01

    We consider the binding energies of Λ hypernuclei (HN), in particular the single-particle (s.p.) energy data, which have been obtained for a wide range of HN with mass numbers A ≤ 89 and for orbital angular momenta ell Λ ≤ 4. We briefly review some of the relevant properties of A hypernuclei. These are nuclei Λ A Z with baryon number A in which a single Λ hyperon (baryon number = 1) is bound to an ordinary nucleus A Z consisting of A - 1 nucleons = Z protons + N neutrons. The Λ hyperon is neutral, has spin 1/2, strangeness S = -1, isospin I = O and a mass M Λ = 1116 MeV/c 2 . Although the Λ interacts with a nucleon, its interaction is only about half as strong as that between two nucleons, and thus very roughly V ΛN ∼ 0.5 V NN . As a result, the two-body ΛN system is unbound, and the lightest bound HN is the three-body hypertriton Λ 3 H in which the Λ is bound to a deuteron with the Λ-d separation energy being only ∼ 0.1 MeV corresponding to an exponential tail of radius ∼ 15 fm exclamation point In strong interactions the strangeness S is of course conserved, and the Λ is distinct from the nucleons. In a HN strangeness changes only in the weak decays of the Λ which can decay either via ''free'' pionic decay Λ → N + π or via induced decay Λ + N → N + N which is only possible in the presence of nucleons. Because of the small energy release the pionic decay is strongly suppressed in all but the lightest HN and the induced decay dominates. However, the weak decay lifetime ∼ 10 -10 s is in fact close to the lifetime of a free Λ. Since this is much longer than the strong interaction time ∼ 10 -22 s we can ignore the weak interactions when considering the binding of HN, just as for ordinary nuclei

  9. The single entity option

    Friedlander, M.C.; Roberts, K.M.

    1997-01-01

    Traditionally, an owner hires an engineer to design a power facility or other project and then circulates the completed plans to several contractors for competitive bidding. Although there are many variations on this theme, there is an alternative method which is growing in popularity--the design-build concept. In this construction method, the same entity designs and constructs the facility. The design builder may be a single firm with both design and construction capacity in-house, or it may be a combination of two or more firms with complementary abilities. If there are multiple firms, they may be structured as a joint venture or with one of the firms prime and the others in a subcontracting role. The critical aspect is that the owner contracts with one entity which has the responsibility for both designing and constructing the facility. According to statistics compiled by the Design-Build Institute of America and F.W. Dodge DATALINE2, a national reporter of construction statistics and information, from April 1995 to April 1996 the number of design-build contracts increased 103 percent over the previous year. Of a total $212 billion construction market, about $37.2 billion--18 percent--was design build. The strongest growth was in the category of industrial--plants, refineries, factories and warehouses--in which the concept use was up more than 300 percent from the previous year

  10. Single-photon sources based on single molecules in solids

    Moerner, W E

    2004-01-01

    Single molecules in suitable host crystals have been demonstrated to be useful single-photon emitters both at liquid-helium temperatures and at room temperature. The low-temperature source achieved controllable emission of single photons from a single terrylene molecule in p-terphenyl by an adiabatic rapid passage technique. In contrast with almost all other single-molecule systems, terrylene single molecules show extremely high photostability under continuous, high-intensity irradiation. A room-temperature source utilizing this material has been demonstrated, in which fast pumping into vibrational sidebands of the electronically excited state achieved efficient inversion of the emissive level. This source yielded a single-photon emission probability p(1) of 0.86 at a detected count rate near 300 000 photons s -1 , with very small probability of emission of more than one photon. Thus, single molecules in solids can be considered as contenders for applications of single-photon sources such as quantum key distribution

  11. Uso de drogas psicotrópicas no Brasil: pesquisa domiciliar envolvendo as 107 maiores cidades do país - 2001 Uso de drogas psicotrópicas en Brasil: investigación domiciliaria en las 107 mayores ciudades del país - 2001 Use of psychotropic drugs in Brazil: household survey in the 107 biggest Brazilian cities - 2001

    José Carlos F. Galduróz

    2005-10-01

    of drugs, alcohol, tobacco and the use of non-medical psychotropics. This study enclosed the 107 biggest cities in Brazil; sample: ages between 12 and 65 years. Sampling in three periods: tax sectors; household and the respondent. Were interviewed 8,589 people. The lifetime use of the alcohol was 68.7%, closer to 70.8% in Chile. The lifetime use of the tobacco was of 41.1%, lower than U.S.A. (70.5%. The lifetime use of the marijuana was of 6.9% closer to Colombia (5.4% and lower than U.S.A. (34.2%. The lifetime use of the cocaine was 2.3%, lower than U.S.A. (11.2%. The lifetime use of solvent was of 5.8%, much lower than the United Kingdom (20.0%. The stimulants have had 1.5% of lifetime use and the anxiolytics with 3.3%. These findings will allow the implantation of adjusted public politics to our reality in the field of the psychotropics drugs.

  12. Advances in single chain technology.

    Gonzalez-Burgos, Marina; Latorre-Sanchez, Alejandro; Pomposo, José A

    2015-10-07

    The recent ability to manipulate and visualize single atoms at atomic level has given rise to modern bottom-up nanotechnology. Similar exquisite degree of control at the individual polymeric chain level for producing functional soft nanoentities is expected to become a reality in the next few years through the full development of so-called "single chain technology". Ultra-small unimolecular soft nano-objects endowed with useful, autonomous and smart functions are the expected, long-term valuable output of single chain technology. This review covers the recent advances in single chain technology for the construction of soft nano-objects via chain compaction, with an emphasis in dynamic, letter-shaped and compositionally unsymmetrical single rings, complex multi-ring systems, single chain nanoparticles, tadpoles, dumbbells and hairpins, as well as the potential end-use applications of individual soft nano-objects endowed with useful functions in catalysis, sensing, drug delivery and other uses.

  13. Nanodiamond Emitters of Single Photons

    Vlasov I.I.

    2015-01-01

    Full Text Available Luminescence properties of single color centers were studied in nanodiamonds of different origin. It was found that single photon emitters could be realized even in molecularsized diamond (less than 2 nm capable of housing stable luminescent center “silicon-vacancy.” First results on incorporation of single-photon emitters based on luminescent nanodiamonds in plasmonic nanoantennas to enhance the photon count rate and directionality, diminish the fluorescence decay time, and provide polarization selectivity are presented.

  14. Single photon sources with single semiconductor quantum dots

    Shan, Guang-Cun; Yin, Zhang-Qi; Shek, Chan Hung; Huang, Wei

    2014-04-01

    In this contribution, we briefly recall the basic concepts of quantum optics and properties of semiconductor quantum dot (QD) which are necessary to the understanding of the physics of single-photon generation with single QDs. Firstly, we address the theory of quantum emitter-cavity system, the fluorescence and optical properties of semiconductor QDs, and the photon statistics as well as optical properties of the QDs. We then review the localization of single semiconductor QDs in quantum confined optical microcavity systems to achieve their overall optical properties and performances in terms of strong coupling regime, efficiency, directionality, and polarization control. Furthermore, we will discuss the recent progress on the fabrication of single photon sources, and various approaches for embedding single QDs into microcavities or photonic crystal nanocavities and show how to extend the wavelength range. We focus in particular on new generations of electrically driven QD single photon source leading to high repetition rates, strong coupling regime, and high collection efficiencies at elevated temperature operation. Besides, new developments of room temperature single photon emission in the strong coupling regime are reviewed. The generation of indistinguishable photons and remaining challenges for practical single-photon sources are also discussed.

  15. Do single women value early retirement more than single men?

    Danø, Anne Møller; Ejrnæs, Mette; Husted, Leif

    2005-01-01

    and health are important determinants of the retirement decision. Furthermore, we find substantial gender differences in the retirement pattern. Healthy single women value retirement more than healthy single men and are willing to reduce their disposable income to 74% of their previous income while men......The focus of this paper is to analyse why a large fraction of single elderly people choose to retire early. A structural model directly based on the individual decision of labour supply is estimated on a sample of singles, where singles are defined as those who are living alone. We find that income...... are willing to reduce the income to 81%. Men's retirement decision is mainly influenced by income and health, whereas women's retirement decision is also affected by education and unemployment experience...

  16. Quantum optics with single quantum dot devices

    Zwiller, Valery; Aichele, Thomas; Benson, Oliver

    2004-01-01

    A single radiative transition in a single-quantum emitter results in the emission of a single photon. Single quantum dots are single-quantum emitters with all the requirements to generate single photons at visible and near-infrared wavelengths. It is also possible to generate more than single photons with single quantum dots. In this paper we show that single quantum dots can be used to generate non-classical states of light, from single photons to photon triplets. Advanced solid state structures can be fabricated with single quantum dots as their active region. We also show results obtained on devices based on single quantum dots

  17. Single-Gender Schools Scrutinized

    Zubrzycki, Jaclyn

    2012-01-01

    This article reports on a study on publicly run schools in the Republic of Trinidad and Tobago which has found that, while single-sex schools may benefit female students who prefer a single-sex environment, they are not inherently beneficial for boys or most girls. While the findings are based on data from one Caribbean nation, experts say they…

  18. Single top t-channel

    Faltermann, Nils

    2017-01-01

    The production of single top quarks allows to study the interplay of top quark physics and the electroweak sector of the standard model. Deviations from predictions can be a hint for physics beyond the standard model. The t-channel is the dominant production mode for single top quarks at the LHC. This talk presents the latest measurements from the ATLAS and CMS collaborations.

  19. Single-electron charging effects

    Ruggiero, S.T.

    1990-01-01

    The status of our project on single-electron tunneling is at this point excellent. As outlined in our original proposal, a key goal in the development of this project was the demonstration and exploration of the microwave properties of single-electron systems. As discussed here, such work has to date been carried out

  20. Single banking supervision and the single supervisory mechanism

    Gheorghe, C. A.

    2013-06-01

    Full Text Available A resolution seems to have been found for the banking crisis. The first steps have been made towards the construction of the Economic and Monetary Union, steps involving the single supervision of banks, in order to avoid the discount of a new financial crisis on the expense of the EU state members. The Single Supervisory Mechanism – SSM is to become effective as of March 1, 2014, at the earliest.

  1. Single Molecule Nano-Metronome

    Buranachai, Chittanon; McKinney, Sean A.; Ha, Taekjip

    2006-01-01

    We constructed a DNA-based nano-mechanical device called the nano-metronome. Our device is made by introducing complementary single stranded overhangs at the two arms of the DNA four-way junction. The ticking rates of this stochastic metronome depend on ion concentrations and can be changed by a set of DNA-based switches to deactivate/reactivate the sticky end. Since the device displays clearly distinguishable responses even with a single basepair difference, it may lead to a single molecule ...

  2. Single Molecule Nano-Metronome

    Buranachai, Chittanon; McKinney, Sean A.; Ha, Taekjip

    2008-01-01

    We constructed a DNA-based nano-mechanical device called the nano-metronome. Our device is made by introducing complementary single stranded overhangs at the two arms of the DNA four-way junction. The ticking rates of this stochastic metronome depend on ion concentrations and can be changed by a set of DNA-based switches to deactivate/reactivate the sticky end. Since the device displays clearly distinguishable responses even with a single basepair difference, it may lead to a single molecule sensor of minute sequence differences of a target DNA. PMID:16522050

  3. Longitudinal single-bunch instabilities

    Migliorati, M.; Palumbo, L.; Rome Univ. La Sapienza, Rome

    2001-02-01

    After introducing the concepts of longitudinal wakefield and coupling impedance, it is reviewed the theory of longitudinal single-bunch collective effects in storage rings. From the Fokker-Planck equation it is first derived the stationary solution describing the natural single-bunch regime, and then treat the problem of microwave instability, showing the different approaches used for estimating the threshold current. The lecture is ended with the semi-empirical laws that allow everyone to obtain the single-bunch behaviour above threshold, and with a description of the simulation codes that are now reliable tools for investigating all these effects

  4. Adverse selection without single crossing

    Schottmüller, Christoph

    2015-01-01

    The single-crossing assumption simplifies the analysis of screening models as local incentive compatibility becomes sufficient for global incentive compatibility. If single crossing is violated, global incentive compatibility constraints have to be taken into account. This paper studies monotone...... solutions in a screening model that allows a one-time violation of single crossing. The results show that local and non-local incentive constraints distort the solution in opposite directions. Therefore, the optimal decision might involve distortions above as well as below the first-best decision...

  5. Thermoelectric single-photon detector

    Kuzanyan, A A; Petrosyan, V A; Kuzanyan, A S

    2012-01-01

    The ability to detect a single photon is the ultimate level of sensitivity in the measurement of optical radiation. Sensors capable of detecting single photons and determining their energy have many scientific and technological applications. Kondo-enhanced Seebeck effect cryogenic detectors are based on thermoelectric heat-to-voltage conversion and voltage readout. We evaluate the prospects of CeB 6 and (La,Ce)B 6 hexaboride crystals for their application as a sensitive element in this type of detectors. We conclude that such detectors can register a single UV photon, have a fast count rate (up to 45 MHz) and a high spectral resolution of 0.1 eV. We calculate the electric potential generated along the thermoelectric sensor upon registering a UV single photon.

  6. Microfluidics for single cell analysis

    Jensen, Marie Pødenphant

    Isolation and manipulation of single cells have gained an increasing interest from researchers because of the heterogeneity of cells from the same cell culture. Single cell analysis can ensure a better understanding of differences between individual cells and potentially solve a variety of clinical...... problems. In this thesis lab on a chip systems for rare single cell analysis are investigated. The focus was to develop a commercial, disposable device for circulating tumour cell (CTC) analysis. Such a device must be able to separate rare cells from blood samples and subsequently capture the specific...... cells, and simultaneously be fabricated and operated at low costs and be user-friendly. These challenges were addressed through development of two microfluidic devices, one for rare cell isolation based on pinched flow fractionation (PFF) and one for single cell capture based on hydrodynamic trapping...

  7. Single-employer Pension Plans

    Pension Benefit Guaranty Corporation — This spreadsheet lists the active single-employer pensions plans insured by PBGC. Plans are identified by name, employer identification number (EIN) and plan number...

  8. Single Sign On Internal (SSOi)

    Department of Veterans Affairs — Provides single sign-on solution for internal facing VA applications. Allows internal users access to a variety of VA systems and applications using a reduced set of...

  9. Single nanoparticle tracking spectroscopic microscope

    Yang, Haw [Moraga, CA; Cang, Hu [Berkeley, CA; Xu, Cangshan [Berkeley, CA; Wong, Chung M [San Gabriel, CA

    2011-07-19

    A system that can maintain and track the position of a single nanoparticle in three dimensions for a prolonged period has been disclosed. The system allows for continuously imaging the particle to observe any interactions it may have. The system also enables the acquisition of real-time sequential spectroscopic information from the particle. The apparatus holds great promise in performing single molecule spectroscopy and imaging on a non-stationary target.

  10. Approaches to single photon detection

    Thew, R.T.; Curtz, N.; Eraerds, P.; Walenta, N.; Gautier, J.-D.; Koller, E.; Zhang, J.; Gisin, N.; Zbinden, H.

    2009-01-01

    We present recent results on our development of single photon detectors, including: gated and free-running InGaAs/InP avalanche photodiodes (APDs); hybrid detection systems based on sum-frequency generation (SFG) and Si APDs-SFG-Si APDs; and SSPDs (superconducting single photon detectors), for telecom wavelengths; as well as SiPM (Silicon photomultiplier) detectors operating in the visible regime.

  11. Single particle tracking and single molecule energy transfer

    Bräuchle, Christoph; Michaelis, Jens

    2009-01-01

    Closing a gap in the literature, this handbook gathers all the information on single particle tracking and single molecule energy transfer. It covers all aspects of this hot and modern topic, from detecting virus entry to membrane diffusion, and from protein folding using spFRET to coupled dye systems, as well recent achievements in the field. Throughout, the first-class editors and top international authors present content of the highest quality, making this a must-have for physical chemists, spectroscopists, molecular physicists and biochemists.

  12. Control of Single-Stage Single-Phase PV inverter

    Ciobotaru, Mihai; Teodorescu, Remus; Blaabjerg, Frede

    2005-01-01

    In this paper the issue of control strategies for single-stage photovoltaic (PV) inverter is addressed. Two different current controllers have been implemented and an experimental comparison between them has been made. A complete control structure for the single-phase PV system is also presented......-forward; - and the grid current controller implemented in two different ways, using the classical proportional integral (PI) and the novel proportional resonant (PR) controllers. The control strategy was tested experimentally on 1.5 kW PV inverter....

  13. Single-tier city logistics model for single product

    Saragih, N. I.; Nur Bahagia, S.; Suprayogi; Syabri, I.

    2017-11-01

    This research develops single-tier city logistics model which consists of suppliers, UCCs, and retailers. The problem that will be answered in this research is how to determine the location of UCCs, to allocate retailers to opened UCCs, to assign suppliers to opened UCCs, to control inventory in the three entities involved, and to determine the route of the vehicles from opened UCCs to retailers. This model has never been developed before. All the decisions will be simultaneously optimized. Characteristic of the demand is probabilistic following a normal distribution, and the number of product is single.

  14. Single Molecule Electronics and Devices

    Tsutsui, Makusu; Taniguchi, Masateru

    2012-01-01

    The manufacture of integrated circuits with single-molecule building blocks is a goal of molecular electronics. While research in the past has been limited to bulk experiments on self-assembled monolayers, advances in technology have now enabled us to fabricate single-molecule junctions. This has led to significant progress in understanding electron transport in molecular systems at the single-molecule level and the concomitant emergence of new device concepts. Here, we review recent developments in this field. We summarize the methods currently used to form metal-molecule-metal structures and some single-molecule techniques essential for characterizing molecular junctions such as inelastic electron tunnelling spectroscopy. We then highlight several important achievements, including demonstration of single-molecule diodes, transistors, and switches that make use of electrical, photo, and mechanical stimulation to control the electron transport. We also discuss intriguing issues to be addressed further in the future such as heat and thermoelectric transport in an individual molecule. PMID:22969345

  15. Testing multistage gain and offset trimming in a single photon counting IC with a charge sharing elimination algorithm

    Krzyżanowska, A.; Gryboś, P.; Szczygieł, R.; Maj, P.

    2015-01-01

    Designing a hybrid pixel detector readout electronics operating in a single photon counting mode is a very challenging process, where many main parameters are optimized in parallel (e.g. gain, noise, and threshold dispersion). Additional requirements for a smaller pixel size with extended functionality push designers to use new deep sub-micron technologies. Minimizing the channel size is possible, however, with a decreased pixel size, the charge sharing effect becomes a more important issue. To overcome this problem, we designed an integrated circuit prototype produced in CMOS 40 nm technology, which has an extended functionality of a single pixel. A C8P1 algorithm for the charge sharing effect compensation was implemented. In the algorithm's first stage the charge is rebuilt in a signal rebuilt hub fed by the CSA (charge sensitive amplifier) outputs from four neighbouring pixels. Then, the pixel with the biggest amount of charge is chosen, after a comparison with all the adjacent ones. In order to process the data in such a complicated way, a certain architecture of a single channel was proposed, which allows for: ⋅ processing the signal with the possibility of total charge reconstruction (by connecting with the adjacent pixels), ⋅ a comparison of certain pixel amplitude to its 8 neighbours, ⋅ the extended testability of each block inside the channel to measure CSA gain dispersion, shaper gain dispersion, threshold dispersion (including the simultaneous generation of different pulse amplitudes from different pixels), ⋅ trimming all the necessary blocks for proper operation. We present a solution for multistage gain and offset trimming implemented in the IC prototype. It allows for minimization of the total charge extraction errors, minimization of threshold dispersion in the pixel matrix and minimization of errors of comparison of certain pixel pulse amplitudes with all its neighbours. The detailed architecture of a single channel is presented

  16. Resolution of Single Spin-Flips of a Single Proton

    Mooser, A.; Blaum, K.; Bräuninger, S.A.; Franke, K.; Leiteritz, C.; Quint, W.; Rodegheri, C.C.; Ulmer, S.; Walz, J.

    2013-04-04

    The spin magnetic moment of a single proton in a cryogenic Penning trap was coupled to the particle's axial motion with a superimposed magnetic bottle. Jumps in the oscillation frequency indicate spin-flips and were identified using a Bayesian analysis.

  17. A multistep single-crystal-to-single-crystal bromodiacetylene dimerization

    Hoheisel, Tobias N.; Schrettl, Stephen; Marty, Roman; Todorova, Tanya K.; Corminboeuf, Clémence; Sienkiewicz, Andrzej; Scopelliti, Rosario; Schweizer, W. Bernd; Frauenrath, Holger

    2013-04-01

    Packing constraints and precise placement of functional groups are the reason that organic molecules in the crystalline state often display unusual physical or chemical properties not observed in solution. Here we report a single-crystal-to-single-crystal dimerization of a bromodiacetylene that involves unusually large atom displacements as well as the cleavage and formation of several bonds. Density functional theory computations support a mechanism in which the dimerization is initiated by a [2 + 1] photocycloaddition favoured by the nature of carbon-carbon short contacts in the crystal structure. The reaction proceeded up to the theoretical degree of conversion without loss of crystallinity, and it was also performed on a preparative scale with good yield. Moreover, it represents the first synthetic pathway to (E)-1,2-dibromo-1,2-diethynylethenes, which could serve as synthetic intermediates for the preparation of molecular carbon scaffolds. Our findings both extend the scope of single-crystal-to-single-crystal reactions and highlight their potential as a synthetic tool for complex transformations.

  18. Protein determination in single corns

    Knorr, J.; Schiekel, M.; Franke, W.; Focke, F.

    1994-01-01

    Determination of protein content in food materials is usually done by analyzing the nitrogen amount by wet chemical Kjeldahl method. An improved accuracy accompanied by smaller analyzing intervals can be achieved using nondestructive neutron activation. Analyses have been performed using 14 MeV neutrons to determine the content of N and P in single wheat corns. Irradiation parameters have been optimized to prevent serious radiation damage in grains. About 200 single corns have been investigated with total net weights ranging from 30 to 70 mg. The tested arrangement allows determination of nitrogen amount in a single corn down to 0.3 mg with an accuracy of better than 4 %. Mean nitrogen concentrations in the range from 9 to 19% per corn have been detected. (author) 5 refs.; 6 figs

  19. Delivery of single accelerated particles

    McNulty, P.J.; Pease, V.P.; Bond, V.P.; Schimmerling, W.; Vosburgh, K.G.; Crebbin, K.; Everette, W.; Howard, J.

    1978-01-01

    It is desirable for certain experiments involving accelerators to have the capability of delivering just a single beam particle to the target area. The essential features of such a one-at-a-time facility are discussed. Two such facilities are described which were implemented at high-energy heavy ion accelerators without having to make major structural changes in the existing beam lines or substantially interfering with other accelerator uses. Two accelerator facilities are described which had the capability of delivering a single beam particle to the target area. This feature is necessary in certain experiments investigating visual phenomena induced by charged particles, other single particle interactions in biology, and other experiments in which the low intensities of cosmic rays need to be simulated. Both facilities were implemented without having to make structural changes in the existing beam lines or substantially interfering with other accelerator uses. (Auth.)

  20. Single-electron charging effects

    Ruggiero, S.T.

    1991-01-01

    The status of our project on single-electron tunneling is, again, excellent. As outlined in our original proposal, a key goal in the development of this project was the demonstration and exploration of the microwave properties of single-electron system. As discussed in this paper such work has to data been carried out. Also as discussed in our previous progress report, the next step in the experimental evolution of the project will be to use lithographically-defined small dots as capacitors as outlined in our proposal. At this point we have made such microdotsdots as will be discussed. We have also continued our work with metal droplets to form single-electron tunnel systems

  1. Single-photon decision maker

    Naruse, Makoto; Berthel, Martin; Drezet, Aurélien; Huant, Serge; Aono, Masashi; Hori, Hirokazu; Kim, Song-Ju

    2015-08-01

    Decision making is critical in our daily lives and for society in general and is finding evermore practical applications in information and communication technologies. Herein, we demonstrate experimentally that single photons can be used to make decisions in uncertain, dynamically changing environments. Using a nitrogen-vacancy in a nanodiamond as a single-photon source, we demonstrate the decision-making capability by solving the multi-armed bandit problem. This capability is directly and immediately associated with single-photon detection in the proposed architecture, leading to adequate and adaptive autonomous decision making. This study makes it possible to create systems that benefit from the quantum nature of light to perform practical and vital intelligent functions.

  2. Health Insurance without Single Crossing

    Boone, Jan; Schottmüller, Christoph

    2017-01-01

    Standard insurance models predict that people with high risks have high insurance coverage. It is empirically documented that people with high income have lower health risks and are better insured. We show that income differences between risk types lead to a violation of single crossing...... in an insurance model where people choose treatment intensity. We analyse different market structures and show the following: If insurers have market power, the violation of single crossing caused by income differences and endogenous treatment choice can explain the empirically observed outcome. Our results do...

  3. Single Cell Isolation and Analysis

    Ping Hu

    2016-10-01

    Full Text Available Increasing evidence shows that the heterogeneity of individual cells within a genetically identical population can be critical to their peculiar function and fate. Conventional cell based assays mainly analysis the average responses from a population cells, while the difference within individual cells may often be masked. The cell size, RNA transcripts and protein expression level are quite different within individual cells and these variations are key point to answer the problems in cancer, neurobiology, stem cell biology, immunology and developmental biology. To better understand the cell-to-cell variations, the single cell analysis can provide much more detailed information which may be helpful for therapeutic decisions in an increasingly personalized medicine. In this review, we will focus on the recent development in single cell analysis, including methods used in single cell isolation, analysis and some application examples. The review provides the historical background to single cell analysis, discusses limitations, and current and future possibilities in this exciting field of research.

  4. Small angle single arm spectrometer

    Chien, C.Y.

    1976-01-01

    A study is given of an experiment described in the 1975 Summer Study to review the adequacy of the apparatus for its physics goals, equipment needs, logistic needs, vacuum chambers, compatibility with other experiments and to summarize its impacts on ISABELLE. The spectrometer is designed to study single particle inclusive spectra near x = 1 with particle identification and good momentum resolution

  5. Single-electron charging effects

    Ruggiero, S.T.

    1991-01-01

    The status of our project on single-electron tunneling is, again, excellent. As outlined in our original proposal, a key goal for this project has been the development of a scanning tunneling instrument for the purpose of imaging individual particles and tunneling into these particles at high magnetic fields. Further progress is discussed in this report

  6. Single liner shipping service design

    Plum, Christian Edinger Munk; Pisinger, David; Salazar-González, Juan-José

    2014-01-01

    The design of container shipping networks is an important logistics problem, involving assets and operational costs measured in billions of dollars. To guide the optimal deployment of the ships, a single vessel round trip is considered by minimizing operational costs and flowing the best paying...

  7. Single port Billroth I gastrectomy

    Jeremy R Huddy

    2013-01-01

    Full Text Available Introduction: Experience has allowed increasingly complex procedures to be undertaken by single port surgery. We describe a technique for single port Billroth I gastrectomy with a hand-sewn intracorporeal anastomosis in the resection of a benign tumour diagnosed incidentally on a background of cholelithiasis. Materials and Methods: Single port Billroth I gastrectomy and cholecystectomy was performed using a transumbilical quadport. Flexible tipped camera and straight conventional instruments were used throughout the procedure. The stomach was mobilised including a limited lymph node dissection and resection margins in the proximal antrum and duodenum were divided with a flexible tipped laparoscopic stapler. The lesser curve was reconstructed and an intracorporal hand sewn two layer end-to-end anastomosis was performed using unidirectional barbed sutures. Intraoperative endoscopy confirmed the anastomosis to be patent without leak. Results: Enteral feed was started on the day of surgery, increasing to a full diet by day 6. Analgesic requirements were a patient-controlled analgesia morphine pump for 4 postoperative days and paracetamol for 6 days. There were no postoperative complications and the patient was discharged on the eighth day. Histology confirmed gastric submucosal lipoma. Discussion: As technology improves more complex procedures are possible by single port laparoscopic surgery. In this case, flexible tipped cameras and unidirectional barbed sutures have facilitated an intracorporal hand-sewn two layer end-to-end anastomosis. Experience will allow such techniques to become mainstream.

  8. Single-mode optical fibres

    Cancellieri, G

    1991-01-01

    This book describes signal propagation in single-mode optical fibres for telecommunication applications. Such description is based on the analysis of field propagation, considering waveguide properties and also some of the particular characteristics of the material fibre. The book covers such recent advances as, coherent transmissions; optical amplification; MIR fibres; polarization maintaining; polarization diversity and photon counting.

  9. CERN single sign on solution

    Ormancey, E

    2008-01-01

    The need for Single Sign On has always been restricted by the absence of cross platform solutions: a single sign on working only on one platform or technology is nearly useless. The recent improvements in Web Services Federation (WS-Federation) standard enabling federation of identity, attribute, authentication and authorization information can now provide real extended Single Sign On solutions. Various solutions have been investigated at CERN and now, a Web SSO solution using some parts of WS-Federation technology is available. Using the Shibboleth Service Provider module for Apache hosted web sites and Microsoft ADFS as the identity provider linked to Active Directory user, users can now authenticate on any web application using a single authentication platform, providing identity, user information (building, phone...) as well as group membership enabling authorization possibilities. A typical scenario: a CERN user can now authenticate on a Linux/Apache website using Windows Integrated credentials, and his Active Directory group membership can be checked before allowing access to a specific web page

  10. Single particle distributions, ch.2

    Blokzijl, R.

    1977-01-01

    A survey of inclusive single particle distributions is given for various particles. A comparison of particle cross-sections measured in K - p experiments at different center of mass energies shows that some of these cross-sections remain almost constant over a wide range of incoming K - momenta

  11. Prospects of Single Tax Payers

    Tofan Ivan M.

    2014-03-01

    Full Text Available The article speaks about problem aspects of taxation, which were set by the state for the single tax administering due to permanent and system changes in the tax legislation. It shows the necessity of search for alternative methods of administering in the process of taxation of single tax payers by fiscal services. The goal of the article is the study of prospects of further taxation of entrepreneurs – single tax payers on the basis of analysis of conditions and principles created by the state for the business. The article used methods of system analysis, comparison, forecasting and modelling. It analyses the process of evolution of the simplified taxation system, accounting and reporting from the moment of its adoption until today. The article presents the structure of the quantitative composition of single tax payers depending on the selected groups. It marks out and characterises administrative and fiscal factors that do not facilitate further development of entrepreneurship in Ukraine. In the result of the conducted studies the article outlines problem aspects of organisation of taxation of the small business and offers specific and real ways of their overcoming or partial solution.

  12. Single-Pilot Workload Management

    Rogers, Jason; Williams, Kevin; Hackworth, Carla; Burian, Barbara; Pruchnicki, Shawn; Christopher, Bonny; Drechsler, Gena; Silverman, Evan; Runnels, Barry; Mead, Andy

    2013-01-01

    Integrated glass cockpit systems place a heavy cognitive load on pilots (Burian Dismukes, 2007). Researchers from the NASA Ames Flight Cognition Lab and the FAA Flight Deck Human Factors Lab examined task and workload management by single pilots. This poster describes pilot performance regarding programming a reroute while at cruise and meeting a waypoint crossing restriction on the initial descent.

  13. Single and Coupled Nanobeam Cavities

    Ivinskaya, Aliaksandra; Lavrinenko, Andrei; Shyroki, Dzmitry M.

    2013-01-01

    for analysis and design of photonic crystal devices, such as 2D ring resonators for filters, single and coupled nanobeam cavities, birefringence in photonic crystal cavities, threshold analysis in photonic crystal lasers, gap solitons in photonic crystals, novel photonic atolls, dynamic characteristics...

  14. A Single-Pulse Integrator

    Miller, Arne

    1974-01-01

    A single-pulse integrator is described. It gives a relative measure of the integral of the output signal from a coil monitor on the Risø 10 MeV linear accelerator, and displays the value on a digital voltmeter. The reproduccibility is found to be better than ±1% for an accelerated pulse charge...

  15. Single photon searches at PEP

    Hollebeek, R.

    1985-12-01

    The MAC and ASP searches for events with a single photon and no other observed particles are reviewed. New results on the number of neutrino generations and limits on selection, photino, squark and gluino masses from the ASP experiment are presented.

  16. Single photon searches at PEP

    Hollebeek, R.

    1985-12-01

    The MAC and ASP searches for events with a single photon and no other observed particles are reviewed. New results on the number of neutrino generations and limits on selection, photino, squark and gluino masses from the ASP experiment are presented

  17. From joint to single audits

    Holm, Claus; Thinggaard, Frank

    2018-01-01

    This study analyses audit quality differences between audits by a single big audit firm and joint audits with either one or two big audit firms. We exploit the unique situation in Denmark beginning on 1 January 2005, at which time a long-standing mandatory joint audit system for listed companies ...

  18. Single molecules and single nanoparticles as windows to the nanoscale

    Caldarola, Martín; Orrit, Michel

    2018-05-01

    Since the first optical detection of single molecules, they have been used as nanometersized optical sensors to explore the physical properties of materials and light-matter interaction at the nanoscale. Understanding nanoscale properties of materials is fundamental for the development of new technology that requires precise control of atoms and molecules when the quantum nature of matter cannot be ignored. In the following lines, we illustrate this journey into nanoscience with some experiments from our group.

  19. Totally extraperitoneal (TEP) bilateral hernioplasty using the Single Site® robotic da Vinci platform (DV-SS TEP): description of the technique and preliminary results.

    Cestari, A; Galli, A C; Sangalli, M N; Zanoni, M; Ferrari, M; Roviaro, G

    2017-06-01

    Laparoendoscopic single site totally extraperitoneal (TEP) hernia repair showed to be a feasible alternative to conventional laparoscopic hernia repair; nevertheless single site surgery, with the loss of instruments triangulation can be a demanding procedure. To overcome those hurdles, the Single Site® (SS) platform of the da Vinci (DV) Si robotic system enables to perform surgical procedures through a 25-mm skin incision, with a stable 3D vision and restoring an adequate triangulation of the surgical instruments. We present in details the technique and the preliminary results of DV-SS TEP, to our knowledge the first cases reported in literature. In March 2016, three consecutive male patients (mean age 46.6 years-mean BMI 25.3) with bilateral symptomatic inguinal hernia were submitted to DV-SS TEP in our institutions. Feasibility, codification of the technique, operative time and perioperative outcomes were recorded. All the procedures were completed as scheduled, with no conversion to other techniques. Mean operative time was 98.6 min, ranging between 155 and 55 min, reflecting the learning curve of the operating room team on this new procedure. No intraoperative or postoperative complications were experienced and all the patients were discharged within 24 h after surgery. Patients reported satisfactory postoperative course, with no recurrence of inguinal hernia and satisfaction in cosmetic result at 6-month follow-up. DV-SS TEP inguinal hernia repair showed to be feasible and effective surgical option for bilateral groin hernia repair. Patients' outcome was uneventful, with optimal cosmetic results. Further studies comparing this innovative technique to TEP or LESS TEP should be promoted.

  20. Single wire drift chamber design

    Krider, J.

    1987-01-01

    This report summarizes the design and prototype tests of single wire drift chambers to be used in Fermilab test beam lines. The goal is to build simple, reliable detectors which require a minimum of electronics. Spatial resolution should match the 300 μm rms resolution of the 1 mm proportional chambers that they will replace. The detectors will be used in beams with particle rates up to 20 KHz. Single track efficiency should be at least 99%. The first application will be in the MT beamline, which has been designed for calibration of CDF detectors. A set of four x-y modules will be used to track and measure the momentum of beam particles

  1. Invariance for Single Curved Manifold

    Castro, Pedro Machado Manhaes de

    2012-01-01

    Recently, it has been shown that, for Lambert illumination model, solely scenes composed by developable objects with a very particular albedo distribution produce an (2D) image with isolines that are (almost) invariant to light direction change. In this work, we provide and investigate a more general framework, and we show that, in general, the requirement for such in variances is quite strong, and is related to the differential geometry of the objects. More precisely, it is proved that single curved manifolds, i.e., manifolds such that at each point there is at most one principal curvature direction, produce invariant is surfaces for a certain relevant family of energy functions. In the three-dimensional case, the associated energy function corresponds to the classical Lambert illumination model with albedo. This result is also extended for finite-dimensional scenes composed by single curved objects. © 2012 IEEE.

  2. Invariance for Single Curved Manifold

    Castro, Pedro Machado Manhaes de

    2012-08-01

    Recently, it has been shown that, for Lambert illumination model, solely scenes composed by developable objects with a very particular albedo distribution produce an (2D) image with isolines that are (almost) invariant to light direction change. In this work, we provide and investigate a more general framework, and we show that, in general, the requirement for such in variances is quite strong, and is related to the differential geometry of the objects. More precisely, it is proved that single curved manifolds, i.e., manifolds such that at each point there is at most one principal curvature direction, produce invariant is surfaces for a certain relevant family of energy functions. In the three-dimensional case, the associated energy function corresponds to the classical Lambert illumination model with albedo. This result is also extended for finite-dimensional scenes composed by single curved objects. © 2012 IEEE.

  3. Theoretical Investigations Regarding Single Molecules

    Pedersen, Kim Georg Lind

    Neoclassical Valence Bond Theory, Quantum Transport, Quantum Interference, Kondo Effect, and Electron Pumping. Trap a single organic molecule between two electrodes and apply a bias voltage across this "molecular junction". When electrons pass through the molecule, the different electron paths can...... interfere destructively or constructively. Destructive interference effects in electron transport could potentially improve thermo-electrics, organic logic circuits and energy harvesting. We have investigated destructive interference in off-resonant transport through organic molecules, and have found a set...

  4. Single lens laser beam shaper

    Liu, Chuyu [Newport News, VA; Zhang, Shukui [Yorktown, VA

    2011-10-04

    A single lens bullet-shaped laser beam shaper capable of redistributing an arbitrary beam profile into any desired output profile comprising a unitary lens comprising: a convex front input surface defining a focal point and a flat output portion at the focal point; and b) a cylindrical core portion having a flat input surface coincident with the flat output portion of the first input portion at the focal point and a convex rear output surface remote from the convex front input surface.

  5. The evolution of single stars

    Tayler, R.J.

    1982-01-01

    The general outline of the evolution of single stars is well understood but at most stages of evolution important uncertainties remain. This paper contains a very personal view of what are the major uncertainties and of what problems remain to be solved before one can be satisfied with the theory. It is suggested that some problems may be essentially insoluble even with the very large and fast computers that are currently available. (author)

  6. Single Nanowire Probe for Single Cell Endoscopy and Sensing

    Yan, Ruoxue

    The ability to manipulate light in subwavelength photonic and plasmonic structures has shown great potentials in revolutionizing how information is generated, transformed and processed. Chemically synthesized nanowires, in particular, offers a unique toolbox not only for highly compact and integrated photonic modules and devices, including coherent and incoherent light sources, waveguides, photodetectors and photovoltaics, but also for new types of nanoscopic bio-probes for spot cargo delivery and in-situ single cell endoscopy and sensing. Such nanowire probes would enable us to carry out intracellular imaging and probing with high spatial resolution, monitor in-vivo biological processes within single living cells and greatly improve our fundamental understanding of cell functions, intracellular physiological processes, and cellular signal pathways. My work is aimed at developing a material and instrumental platform for such single nanowire probe. Successful optical integration of Ag nanowire plasmonic waveguides, which offers deep subwavelength mode confinement, and conventional photonic waveguides was demonstrated on a single nanowire level. The highest plasmonic-photonic coupling efficiency coupling was found at small coupling angles and low input frequencies. The frequency dependent propagation loss was observed in Ag nanowire and was confirmed by quantitative measurement and in agreement with theoretical expectations. Rational integration of dielectric and Ag nanowire waveguide components into hybrid optical-plasmonic routing devices has been demonstrated. This capability is essential for incorporating sub-100nm Ag nanowire waveguides into optical fiber based nanoprobes for single cell endoscopy. The nanoprobe system based on single nanowire waveguides was demonstrated by optically coupling semiconductor or metal nanowire with an optical fiber with tapered tip. This nanoprobe design requires minimal instrumentation which makes it cost efficient and readily

  7. Alternate Double Single Track Lines

    Moraga Contreras, P.; Grande Andrade, Z.; Castillo Ron, E.

    2016-07-01

    The paper discusses the advantages and shortcomings of alternate double single track (ADST) lines with respect to double track lines for high speed lines. ADST lines consists of sequences of double and single track segments optimally selected in order to reduce the construction and maintenance costs of railway lines and to optimize the timetables used to satisfy a given demand. The single tracks are selected to coincide with expensive segments (tunnels and viaducts) and the double tracks are chosen to coincide with flat areas and only where they are necessary. At the same time, departure times are adjusted for trains to cross at the cheap double track segments. This alternative can be used for new lines and also for existing conventional lines where some new tracks are to be constructed to reduce travel time (increase speed). The ADST proposal is illustrated with some examples of both types (new lines and where conventional lines exist), including the Palencia-Santander, the Santiago-Valparaíso-Viña del Mar and the Dublin-Belfast lines, where very important reductions (90 %) are obtained, especially where a railway infrastructure already exist. (Author)

  8. Measuring single-cell density.

    Grover, William H; Bryan, Andrea K; Diez-Silva, Monica; Suresh, Subra; Higgins, John M; Manalis, Scott R

    2011-07-05

    We have used a microfluidic mass sensor to measure the density of single living cells. By weighing each cell in two fluids of different densities, our technique measures the single-cell mass, volume, and density of approximately 500 cells per hour with a density precision of 0.001 g mL(-1). We observe that the intrinsic cell-to-cell variation in density is nearly 100-fold smaller than the mass or volume variation. As a result, we can measure changes in cell density indicative of cellular processes that would be otherwise undetectable by mass or volume measurements. Here, we demonstrate this with four examples: identifying Plasmodium falciparum malaria-infected erythrocytes in a culture, distinguishing transfused blood cells from a patient's own blood, identifying irreversibly sickled cells in a sickle cell patient, and identifying leukemia cells in the early stages of responding to a drug treatment. These demonstrations suggest that the ability to measure single-cell density will provide valuable insights into cell state for a wide range of biological processes.

  9. Signaling profiling at the single-cell level identifies a distinct signaling signature in murine hematopoietic stem cells.

    Du, Juan; Wang, Jinyong; Kong, Guangyao; Jiang, Jing; Zhang, Jingfang; Liu, Yangang; Tong, Wei; Zhang, Jing

    2012-07-01

    Hematopoietic stem cell (HSC) function is tightly regulated by cytokine signaling. Although phospho-flow cytometry allows us to study signaling in defined populations of cells, there has been tremendous hurdle to carry out this study in rare HSCs due to unrecoverable critical HSC markers, low HSC number, and poor cell recovery rate. Here, we overcame these difficulties and developed a "HSC phospho-flow" method to analyze cytokine signaling in murine HSCs at the single-cell level and compare HSC signaling profile to that of multipotent progenitors (MPPs), a cell type immediately downstream of HSCs, and commonly used Lin(-) cKit(+) cells (LK cells, enriched for myeloid progenitors). We chose to study signaling evoked from three representative cytokines, stem cell factor (SCF) and thrombopoietin (TPO) that are essential for HSC function and granulocyte macrophage-colony-stimulating factor (GM-CSF) that is dispensable for HSCs. HSCs display a distinct TPO and GM-CSF signaling signature from MPPs and LK cells, which highly correlates with receptor surface expression. In contrast, although majority of LK cells express lower levels of cKit than HSCs and MPPs, SCF-evoked ERK1/2 activation in LK cells shows a significantly increased magnitude for a prolonged period. These results suggest that specific cellular context plays a more important role than receptor surface expression in SCF signaling. Our study of HSC signaling at the homeostasis stage paves the way to investigate signaling changes in HSCs under conditions of stress, aging, and hematopoietic diseases. Copyright © 2012 AlphaMed Press.

  10. ON BIPOLAR SINGLE VALUED NEUTROSOPHIC GRAPHS

    Said Broumi; Mohamed Talea; Assia Bakali; Florentin Smarandache

    2016-01-01

    In this article, we combine the concept of bipolar neutrosophic set and graph theory. We introduce the notions of bipolar single valued neutrosophic graphs, strong bipolar single valued neutrosophic graphs, complete bipolar single valued neutrosophic graphs, regular bipolar single valued neutrosophic graphs and investigate some of their related properties.

  11. A First-Principle Theoretical Study of Mechanical and Electronic Properties in Graphene Single-Walled Carbon Nanotube Junctions

    Ning Yang

    2017-11-01

    Full Text Available The new three-dimensional structure that the graphene connected with SWCNTs (G-CNTs, Graphene Single-Walled Carbon Nanotubes can solve graphene and CNTs′ problems. A comprehensive study of the mechanical and electrical performance of the junctions was performed by first-principles theory. There were eight types of junctions that were constituted by armchair and zigzag graphene and (3,3, (4,0, (4,4, and (6,0 CNTs. First, the junction strength was investigated. Generally, the binding energy of armchair G-CNTs was stronger than that of zigzag G-CNTs, and it was the biggest in the armchair G-CNTs (6,0. Likewise, the electrical performance of armchair G-CNTs was better than that of zigzag G-CNTs. Charge density distribution of G-CNTs (6,0 was the most homogeneous. Next, the impact factors of the electronic properties of armchair G-CNTs were investigated. We suggest that the band gap is increased with the length of CNTs, and its value should be dependent on the combined effect of both the graphene’s width and the CNTs’ length. Last, the relationship between voltage and current (U/I were studied. The U/I curve of armchair G-CNTs (6,0 possessed a good linearity and symmetry. These discoveries will contribute to the design and production of G-CNT-based devices.

  12. Distance education and diabetes empowerment: A single-blind randomized control trial.

    Zamanzadeh, Vahid; Zirak, Mohammad; Hemmati Maslakpak, Masomeh; Parizad, Naser

    2017-11-01

    Diabetes is one of the biggest problems in healthcare systems and kills many people every year. Diabetes management is impossible when only utilizing medication. So, patients must be educated to manage their diabetes. This study aims to assess the effect of education by telephone and short message service on empowering patients with type 2 diabetes (primary outcome). A single-blind randomized controlled trial was conducted in the Urmia diabetes association in Iran. Sixty six participants with definitive diagnosis of type 2 diabetes entered into the study. Patients with secondary health problems were excluded. Patients were selected by simple random sampling then allocated into intervention (n=33) and control (n=33) groups. The intervention group received an educational text message daily and instructive phone calls three days a week for three months along with usual care. The Diabetes Empowerment Scale (DES) with confirmed validity and reliability was used for collecting data. Data was analyzed using SPSS V6.1. Independent t-test, paired t-test and chi-square were used to analyze the data. The empowerment of the intervention group compared with the control group significantly improved after three months of distance education (p<0.00, EF=1. 16). The study findings show that the distance education has a significant effect on empowering patients with type 2 diabetes. Therefore, using distance education along with other diabetes management intervention is highly effective and should be part of the care in diabetes treatment. Copyright © 2016 Diabetes India. Published by Elsevier Ltd. All rights reserved.

  13. Experimental techniques for single cell and single molecule biomechanics

    Lim, C.T.; Zhou, E.H.; Li, A.; Vedula, S.R.K.; Fu, H.X.

    2006-01-01

    Stresses and strains that act on the human body can arise either from external physical forces or internal physiological environmental conditions. These biophysical interactions can occur not only at the musculoskeletal but also cellular and molecular levels and can determine the health and function of the human body. Here, we seek to investigate the structure-property-function relationship of cells and biomolecules so as to understand their important physiological functions as well as establish possible connections to human diseases. With the recent advancements in cell and molecular biology, biophysics and nanotechnology, several innovative and state-of-the-art experimental techniques and equipment have been developed to probe the structural and mechanical properties of biostructures from the micro- down to picoscale. Some of these experimental techniques include the optical or laser trap method, micropipette aspiration, step-pressure technique, atomic force microscopy and molecular force spectroscopy. In this article, we will review the basic principles and usage of these techniques to conduct single cell and single molecule biomechanics research

  14. North-south cooperation in international atmospheric programs

    Roederer, J. G.

    The study of the inner workings of the atmosphere and how it links biosphere, oceans, soil, rocks, human systems and near-earth space into one single whole is one of the most difficult and ambitious endeavors of humankind. The biggest challenge is to identify and separate natural from human-induced changes and provide scientific information to allow governments formulate and implement policies that reconcile regional development with global environmental protection. Developing countries have a crucial role to play: they can offer much- needed human talent, labor and geographic coverage for the daunting task of monitoring and interpreting the complex, non-linear and chaotic system under study. Researchers engaged in the study of the atmosphere are confronted with scientific questions whose answers can have tremendous economic and political implications. This paper will discuss some of the organizational, political and psychological hurdles that must be considered and overcome in the planning of international programs of atmospheric research.

  15. Single-edition quadrangle maps

    ,

    1998-01-01

    In August 1993, the U.S. Geological Survey's (USGS) National Mapping Division and the U.S. Department of Agriculture's Forest Service signed an Interagency Agreement to begin a single-edition joint mapping program. This agreement established the coordination for producing and maintaining single-edition primary series topographic maps for quadrangles containing National Forest System lands. The joint mapping program saves money by eliminating duplication of effort by the agencies and results in a more frequent revision cycle for quadrangles containing national forests. Maps are revised on the basis of jointly developed standards and contain normal features mapped by the USGS, as well as additional features required for efficient management of National Forest System lands. Single-edition maps look slightly different but meet the content, accuracy, and quality criteria of other USGS products. The Forest Service is responsible for the land management of more than 191 million acres of land throughout the continental United States, Alaska, and Puerto Rico, including 155 national forests and 20 national grasslands. These areas make up the National Forest System lands and comprise more than 10,600 of the 56,000 primary series 7.5-minute quadrangle maps (15-minute in Alaska) covering the United States. The Forest Service has assumed responsibility for maintaining these maps, and the USGS remains responsible for printing and distributing them. Before the agreement, both agencies published similar maps of the same areas. The maps were used for different purposes, but had comparable types of features that were revised at different times. Now, the two products have been combined into one so that the revision cycle is stabilized and only one agency revises the maps, thus increasing the number of current maps available for National Forest System lands. This agreement has improved service to the public by requiring that the agencies share the same maps and that the maps meet a

  16. Patterning of Perovskite Single Crystals

    Corzo, Daniel

    2017-06-12

    As the internet-of-things hardware integration continues to develop and the requirements for electronics keep diversifying and expanding, the necessity for specialized properties other than the classical semiconductor performance becomes apparent. The success of emerging semiconductor materials depends on the manufacturability and cost as much as on the properties and performance they offer. Solution-based semiconductors are an emerging concept that offers the advantage of being compatible with large-scale manufacturing techniques and have the potential to yield high-quality electronic devices at a lower cost than currently available solutions. In this work, patterns of high-quality MAPbBr3 perovskite single crystals in specific locations are achieved through the modification of the substrate properties and solvent engineering. The fabrication of the substrates involved modifying the surface adhesion forces through functionalization with self-assembled monolayers and patterning them by photolithography processes. Spin coating and blade coating were used to deposit the perovskite solution on the modified silicon substrates. While single crystal perovskites were obtained with the modification of substrates alone, solvent engineering helped with improving the Marangoni flows in the deposited droplets by increasing the contact angle and lowering the evaporation rate, therefore controlling and improving the shape of the grown perovskite crystals. The methodology is extended to other types of perovskites such as the transparent MAPbCl3 and the lead-free MABi2I9, demonstrating the adaptability of the process. Adapting the process to electrode arrays opened up the path towards the fabrication of optoelectronic devices including photodetectors and field-effect transistors, for which the first iterations are demonstrated. Overall, manufacturing and integration techniques permitting the fabrication of single crystalline devices, such as the method in this thesis work, are

  17. Investigation of single event latchup

    Xue Yuxiong; Yang Shengsheng; Cao Zhou; Ba Dedong; An Heng; Chen Luojing; Guo Gang

    2012-01-01

    Radiation effects on avionics microelectronics are important reliability issues for many space applications. In particular, single-event latchup (SEL) phenomenon is a major threat to CMOS integrated circuits in space systems. To effectively circumvent the failure, it is important to know the behavior of such devices during latchup. In this paper, the mechanisms for SEL in CMOS devices are investigated. Several microelectronic devices used in avionics are tested using heavy ion beams, pulsed laser and 252 Cf source. Based on the SEL test results, SEL-hardening and monitoring methods for preventing SEL from the systems design level are proposed. (authors)

  18. Single-cell photoacoustic thermometry

    Gao, Liang; Wang, Lidai; Li, Chiye; Liu, Yan; Ke, Haixin; Zhang, Chi

    2013-01-01

    Abstract. A novel photoacoustic thermometric method is presented for simultaneously imaging cells and sensing their temperature. With three-seconds-per-frame imaging speed, a temperature resolution of 0.2°C was achieved in a photo-thermal cell heating experiment. Compared to other approaches, the photoacoustic thermometric method has the advantage of not requiring custom-developed temperature-sensitive biosensors. This feature should facilitate the conversion of single-cell thermometry into a routine lab tool and make it accessible to a much broader biological research community. PMID:23377004

  19. Single event upset test programs

    Russen, L.C.

    1984-11-01

    It has been shown that the heavy ions in cosmic rays can give rise to single event upsets in VLSI random access memory devices (RAMs). Details are given of the programs written to test 1K, 4K, 16K and 64K memories during their irradiation with heavy charged ions, in order to simulate the effects of cosmic rays in space. The test equipment, which is used to load the memory device to be tested with a known bit pattern, and subsequently interrogate it for upsets, or ''flips'', is fully described. (author)

  20. SINGLE HEATER TEST FINAL REPORT

    J.B. Cho

    1999-05-01

    The Single Heater Test is the first of the in-situ thermal tests conducted by the U.S. Department of Energy as part of its program of characterizing Yucca Mountain in Nevada as the potential site for a proposed deep geologic repository for the disposal of spent nuclear fuel and high-level nuclear waste. The Site Characterization Plan (DOE 1988) contained an extensive plan of in-situ thermal tests aimed at understanding specific aspects of the response of the local rock-mass around the potential repository to the heat from the radioactive decay of the emplaced waste. With the refocusing of the Site Characterization Plan by the ''Civilian Radioactive Waste Management Program Plan'' (DOE 1994), a consolidated thermal testing program emerged by 1995 as documented in the reports ''In-Situ Thermal Testing Program Strategy'' (DOE 1995) and ''Updated In-Situ Thermal Testing Program Strategy'' (CRWMS M&O 1997a). The concept of the Single Heater Test took shape in the summer of 1995 and detailed planning and design of the test started with the beginning fiscal year 1996. The overall objective of the Single Heater Test was to gain an understanding of the coupled thermal, mechanical, hydrological, and chemical processes that are anticipated to occur in the local rock-mass in the potential repository as a result of heat from radioactive decay of the emplaced waste. This included making a priori predictions of the test results using existing models and subsequently refining or modifying the models, on the basis of comparative and interpretive analyses of the measurements and predictions. A second, no less important, objective was to try out, in a full-scale field setting, the various instruments and equipment to be employed in the future on a much larger, more complex, thermal test of longer duration, such as the Drift Scale Test. This ''shake down'' or trial aspect of the Single Heater Test applied

  1. SINGLE HEATER TEST FINAL REPORT

    J.B. Cho

    1999-01-01

    The Single Heater Test is the first of the in-situ thermal tests conducted by the U.S. Department of Energy as part of its program of characterizing Yucca Mountain in Nevada as the potential site for a proposed deep geologic repository for the disposal of spent nuclear fuel and high-level nuclear waste. The Site Characterization Plan (DOE 1988) contained an extensive plan of in-situ thermal tests aimed at understanding specific aspects of the response of the local rock-mass around the potential repository to the heat from the radioactive decay of the emplaced waste. With the refocusing of the Site Characterization Plan by the ''Civilian Radioactive Waste Management Program Plan'' (DOE 1994), a consolidated thermal testing program emerged by 1995 as documented in the reports ''In-Situ Thermal Testing Program Strategy'' (DOE 1995) and ''Updated In-Situ Thermal Testing Program Strategy'' (CRWMS M and O 1997a). The concept of the Single Heater Test took shape in the summer of 1995 and detailed planning and design of the test started with the beginning fiscal year 1996. The overall objective of the Single Heater Test was to gain an understanding of the coupled thermal, mechanical, hydrological, and chemical processes that are anticipated to occur in the local rock-mass in the potential repository as a result of heat from radioactive decay of the emplaced waste. This included making a priori predictions of the test results using existing models and subsequently refining or modifying the models, on the basis of comparative and interpretive analyses of the measurements and predictions. A second, no less important, objective was to try out, in a full-scale field setting, the various instruments and equipment to be employed in the future on a much larger, more complex, thermal test of longer duration, such as the Drift Scale Test. This ''shake down'' or trial aspect of the Single Heater Test applied not just to the hardware, but also to the teamwork and cooperation between

  2. Single wafer rapid thermal multiprocessing

    Saraswat, K.C.; Moslehi, M.M.; Grossman, D.D.; Wood, S.; Wright, P.; Booth, L.

    1989-01-01

    Future success in microelectronics will demand rapid innovation, rapid product introduction and ability to react to a change in technological and business climate quickly. These technological advances in integrated electronics will require development of flexible manufacturing technology for VLSI systems. However, the current approach of establishing factories for mass manufacturing of chips at a cost of more than 200 million dollars is detrimental to flexible manufacturing. The authors propose concepts of a micro factory which may be characterized by more economical small scale production, higher flexibility to accommodate many products on several processes, and faster turnaround and learning. In-situ multiprocessing equipment where several process steps can be done in sequence may be a key ingredient in this approach. For this environment to be flexible, the equipment must have ability to change processing environment, requiring extensive in-situ measurements and real time control. This paper describes the development of a novel single wafer rapid thermal multiprocessing (RTM) reactor for next generation flexible VLSI manufacturing. This reactor will combine lamp heating, remote microwave plasma and photo processing in a single cold-wall chamber, with applications for multilayer in-situ growth and deposition of dielectrics, semiconductors and metals

  3. Single-Molecule Stochastic Resonance

    K. Hayashi

    2012-08-01

    Full Text Available Stochastic resonance (SR is a well-known phenomenon in dynamical systems. It consists of the amplification and optimization of the response of a system assisted by stochastic (random or probabilistic noise. Here we carry out the first experimental study of SR in single DNA hairpins which exhibit cooperatively transitions from folded to unfolded configurations under the action of an oscillating mechanical force applied with optical tweezers. By varying the frequency of the force oscillation, we investigate the folding and unfolding kinetics of DNA hairpins in a periodically driven bistable free-energy potential. We measure several SR quantifiers under varied conditions of the experimental setup such as trap stiffness and length of the molecular handles used for single-molecule manipulation. We find that a good quantifier of the SR is the signal-to-noise ratio (SNR of the spectral density of measured fluctuations in molecular extension of the DNA hairpins. The frequency dependence of the SNR exhibits a peak at a frequency value given by the resonance-matching condition. Finally, we carry out experiments on short hairpins that show how SR might be useful for enhancing the detection of conformational molecular transitions of low SNR.

  4. Laparoendoscopic single site surgery in urology: A single centre experience

    Arvind P Ganpule

    2012-01-01

    Full Text Available Objective : To analyze our experience of 87 cases with single port surgery, which is also known as laparoendoscopic single site surgery (LESS. Materials and Methods: Case records of all LESS procedures performed between December 2007 and June 2010 were analysed. The procedures performed were donor nephrectomy (n=45, simple nephrectomy (n=27, radical nephrectomy (n=5, pyeloplasty (n=9, and ureteroneocystostomy (n=1. Parameters analysed were operating room (OR time, estimated blood loss (EBL, visual analogue score (VAS, and complications in all patients undergoing LESS procedure and additionally, warm ischaemia time (WIT and graft outcome in patients undergoing LESS donor nephrectomy. In reconstructive procedures, the functional assessment was performed with a diuretic renogram at 6 months. Results: In LESS donor nephrectomy, the mean WIT was 6.9 ± 1.9 min. Mean serum creatinine in recipients at 1 month was 0.96 ± 0.21 mg%. We encountered one instance each of renal artery injury, renal vein injury, large bowel injury, minor cortical laceration at the upper pole and two instances of diaphragmatic injury. In LESS simple nephrectomy, the average OR time was 148.7 ± 52.2 min and hospital stay was 3.7 ± 1.2 days. There was one instance of large bowel injury during specimen retrieval. In LESS radical nephrectomy, the average OR time was 202.5 ± 35.7 min and average hospital stay was 4.2 ± 1.3 days. 6 patients of LESS pyeloplasty completed follow up with a diuretic renogram showing a good drainage. LESS ureteroneocystostomy could also be performed successfully without any complications. Conclusion: LESS surgery can be accomplished safely in nephrectomy and reconstructive procedures such as pyeloplasty and ureteroneocystostomy with equivalent outcomes as standard laparoscopy and with added benefits of cosmesis and quicker convalescence. LESS donor nephrectomy is a technically feasible procedure; current status of procedure needs to be proved with

  5. Single bunch fast longitudinal instability

    Wang, J.M.; Pellegrini, C.

    1979-01-01

    Single bunch longitudinal instability producing an increase of the bunch area have been observed in proton synchrotron and storage rings. Signals at microwave frequencies are observed during the bunch blow-up and because of this the effect has been called the microwave instability. A similar increase in bunch area is observed also in electron storage rings, where it is usually referred to as the bunch lengthening effect. This paper is an attempt to obtain a more general theory of this effect. Here we describe the model used and the method of calculation, together with some general results. More detailed results will be given in another paper. The main result is the derivation of a condition for the existence of a fast longitudinal bunch blow-up. This condition is a generalized threshold formula, showing explicitly the dependence on the bunch energy spread and length. This condition is qualitatively in agreement with Boussard's suggestion

  6. Single-bunch kicker pulser

    Frey, W.W.

    1983-01-01

    The single-bunch kicker magnet is powered by a capacitor discharge pulser. The ferrite-core magnet is used to kick out one of twelve proton bunches circulating in the AGS (Alternating Gradient Synchrotron) into the experimental area. The magnet current pulse has a half-sinusoid shape, with a peak current of 2800 A. The pulse current rises and falls to zero, with minimum undershoot, in 410 nsec to minimize effects on adjacent bunches. The magnet inductance is 1.0 μHy. The pulser is mounted on the kicker magnet in the AGS ring, and is exposed to ionizing radiation. The HVDC power supply, controls, monitoring, and auxiliary circuits are housed approximately 300 feet away external to the ring. A two-gap thyratron is used to discharge the energy storage capacitor. Two hydrogen diodes are series connected to function as an inverse diode

  7. Single-bunch kicker pulser

    Frey, W.W.

    1983-01-01

    The single-bunch kicker magnet is powered by a capacitor discharge pulser. The ferrite-core magnet is used to kick out one of twelve proton bunches circulating in the AGS (Alternating Gradient Synchrotron) into the experimental area. The magnet current pulse has a half-sinusoid shape, with a peak current of 2800 A. The pulse current rises and falls to zero, with minimum undershoot, in 410 nsec to minimize effects on adjacent bunches. The magnet inductance is 1.0 ..mu..Hy. The pulser is mounted on the kicker magnet in the AGS ring, and is exposed to ionizing radiation. The HVDC power supply, controls, monitoring, and auxiliary circuits are housed approximately 300 feet away external to the ring. A two-gap thyratron is used to discharge the energy storage capacitor. Two hydrogen diodes are series connected to function as an inverse diode.

  8. Single-contact tunneling thermometry

    Maksymovych, Petro

    2016-02-23

    A single-contact tunneling thermometry circuit includes a tunnel junction formed between two objects. Junction temperature gradient information is determined based on a mathematical relationship between a target alternating voltage applied across the junction and the junction temperature gradient. Total voltage measured across the junction indicates the magnitude of the target alternating voltage. A thermal gradient is induced across the junction. A reference thermovoltage is measured when zero alternating voltage is applied across the junction. An increasing alternating voltage is applied while measuring a thermovoltage component and a DC rectification voltage component created by the applied alternating voltage. The target alternating voltage is reached when the thermovoltage is nullified or doubled by the DC rectification voltage depending on the sign of the reference thermovoltage. Thermoelectric current and current measurements may be utilized in place of the thermovoltage and voltage measurements. The system may be automated with a feedback loop.

  9. Single fatherhood due to cancer.

    Yopp, Justin M; Rosenstein, Donald L

    2012-12-01

    Cancer is a leading cause of widowed fatherhood in the USA. Fathers whose spouses have died from cancer constitute a potentially vulnerable population as they adjust to their role as sole or primary caregiver while managing their own grief and that of their children. The importance of addressing the psychological needs of widowed fathers is underscored by data showing that father's coping and emotional availability are closely tied to their bereaved children's mental health. Surprisingly, scant attention has been given to the phenomenon of widowed fatherhood with virtually no clinical resources or research studies devoted to fathers who have lost their wives to cancer. This commentary highlights key challenges facing this underserved population of widowers and calls for development of research agendas and clinical interventions for single fathers due to cancer. Copyright © 2011 John Wiley & Sons, Ltd.

  10. Multiple single-centered attractors

    Dominic, Pramod; Mandal, Taniya; Tripathy, Prasanta K.

    2014-01-01

    In this paper we study spherically symmetric single-centered attractors in N=2 supergravity in four dimensions. The attractor points are obtained by extremising the effective black hole potential in the moduli space. Both supersymmetric as well as non-supersymmetric attractors exist in mutually exclusive domains of the charge lattice. We construct axion free supersymmetric as well as non-supersymmetric multiple attractors in a simple two parameter model. We further obtain explicit examples of two distinct non-supersymmetric attractors in type IIA string theory compactified on K3×T"2 carrying D0−D4−D6 charges. We compute the entropy of these attractors and analyse their stability in detail.

  11. Single photon emission computerized tomography

    Hooge, P. de.

    1983-01-01

    In this thesis two single-photon emission tomographic techniques are presented: (a) longitudinal tomography with a rotating slanting-hole collimator, and (b) transversal tomography with a rotating gamma camera. These methods overcome the disadvantages of conventional scintigraphy. Both detection systems and the image construction methods are explained and comparisons with conventional scintigraphy are drawn. One chapter is dedicated to the determination of system parameters like spatial resolution, contrast, detector uniformity, and size of the object, by phantom studies. In separate chapters the results are presented of detection of tumors and metastases in the liver and the liver hilus; skeletal diseases; various pathological aberrations of the brain; and myocardial perfusion. The possible use of these two ect's for other organs and body areas is discussed in the last chapter. (Auth.)

  12. Single bunch fast longitudinal instability

    Wang, J.M.; Pellegrini, C.

    1979-01-01

    Single bunch longitudinal instability producing an increase of the bunch areas has been observed in proton synchrotron and storage rings. Singals at microwave frequencies are observed during the bunch blow-up and because of this the effect has been called the microwave instability. A similar increase in bunch area is observed also in electron storage rings, where it is usually referred to as the bunch lengthening effect. This paper is an attempt to obtain a more general theory of this effect. Here we describe the model used and the method of calculation, together with some general results. The main result of this paper is the derivation of a condition for the existence of a fast longitudinal bunch blow-up. This condition is a generalized threshold formula, showing explicitly the dependence on the bunch energy spread and length

  13. Chemical Transfer (Single Small-Scale) Facility

    Federal Laboratory Consortium — Description/History: Chemistry laboratoryThe Chemical Transfer Facility (CTF)  is the only U.S. single small-scale  facility, a single repository for the Army’s...

  14. Managing the Earth's Biggest Mass Gathering Event and WASH Conditions: Maha Kumbh Mela (India).

    Baranwal, Annu; Anand, Ankit; Singh, Ravikant; Deka, Mridul; Paul, Abhishek; Borgohain, Sunny; Roy, Nobhojit

    2015-04-13

    Mass gatherings including a large number of people makes the planning and management of the event a difficult task. Kumbh Mela is one such, internationally famous religious mass gathering. It creates the substantial challenge of creating a temporary city in which millions of people can stay for a defined period of time. The arrangements need to allow this very large number of people to reside with proper human waste disposal, medical services, adequate supplies of food and clean water, transportation etc. We report a case study of Maha Kumbh, 2013 which focuses on the management and planning that went into the preparation of Kumbh Mela and understanding its water, sanitation and hygiene conditions. It was an observational cross-sectional study, the field work was done for 13 days, from 21 January to 2 February 2013. Our findings suggest that the Mela committee and all other agencies involved in Mela management proved to be successful in supervising the event and making it convenient, efficient and safe. Health care services and water sanitation and hygiene conditions were found to be satisfactory. BhuleBhatke Kendra (Center for helping people who got separated from their families) had the major task of finding missing people and helping them to meet their families. Some of the shortfalls identified were that drainage was a major problem and some fire incidents were reported. Therefore, improvement in drainage facilities and reduction in fire incidents are essential to making Mela cleaner and safer. The number of persons per toilet was high and there were no separate toilets for males and females. Special facilities and separate toilets for men and women will improve their stay in Mela. Inculcation of modern methods and technologies are likely to help in supporting crowd management and improving water, sanitation and hygiene conditions in the continuously expanding KumbhMela, in the coming years.

  15. Original oilpatch; the biggest Canadian oil company laid its cornerstone in Sarnia 100 years ago

    Faulkner, P.

    2000-01-01

    The end of the 20. century also marked the occasion of 100 years of oil refining by Imperial Oil, the largest oil company in Canada. The first commercial oil well was dug at Oil Springs, near Petrolia in southwestern Ontario in the days when the only market for crude oil was kerosene for lamps and cooking. The original well today occupies the doorstep of the Oil Museum of Canada, which contains the records of the birth and growth of the industry which flourished long before anyone had dreamt of Leduc in Alberta, OPEC, or the myriads of petrochemical products, from nylon stockings and rubber tires to bubble bath and detergents, that are common place today. Documents at the Museum reveal that the first oil tanked for commercial sale came from a well at Oil Springs in 1858, a year ahead of the Titusville, Pennsylvania claim. By 1860 production reached a maximum of 800 barrels a day and Canada's first oilpatch was born. The original production equipment, primitive but durable, can be seen at the second local museum, the outdoor Discovery at Petrolia. Refining prior to the start of Imperial in 1880, was done by boiling down crude oil in cast iron vats to isolate kerosene, then the only byproduct of any use. At one stage, there were about 100 small refineries in southern Ontario. Sarnia became the centre of Canadian oil refining after Imperial was sold to the Rockefeller's Standard Oil of New York, who relocated it from Petrolia in 1898. With the arrival of the horseless carriage, gasoline had become a major byproduct. The refinery was rebuilt ; by 1927 it processed 15,500 barrels a day and manufactured 381 products, including vast numbers of candles. Today, plant capacity is up to 120,000 barrels a day. Although southwestern Ontario has long been overshadowed by Alberta as an oil producer, there are still some 600 active wells in the region, and a dozen entrepreneurs still ship about 60,000 barrels a year of southwest Ontario oil to Sarnia for refining. Imperial still retains its status of being the largest oil producer, refiner and retailer in Canada; as of 1999, 2591 of the national total of 13,748 service stations belonged to Imperial, nearly 60 per cent more than Petro-Canada, the second largest Canadian retailer of petroleum products

  16. Multi-slice helical CT: biggest pitch does not mean dosimetric bargain

    Cordoliani, Y.S.

    2000-01-01

    This article explains the point of the definition of the pitch, definition different from the point of view of the constructor and the definition used in the normalisation documents. It is important to dissociate the detection step ( displacement of the way divided by the thickness of the reconstructed hits) and the acquisition step (displacement of the way divided by the product of the number of hits simultaneously achieved by the nominal thickness of hit). This last one is the only step that answers to the step definition, still current in the normalisation documents and it should be the only used by the constructors. As irradiation is inversely proportional to the pitch, the definition of this one becomes a part of radiation protection and explains why different radiation doses can be gotten. (N.C.)

  17. IT costs in the Baltic States : hardware still takes the biggest part / Mika Ollikainen

    Ollikainen, Mika

    2001-01-01

    Uuringust, mille käigus vaadeldi Balti riikides infotehnoloogiale tehtavate kulutuste osakaalu suurte ning keskmise suurusega organisatsioonide eelarves. Tabelid: top 5 IT projektid Balti riikides 2001; IT kulutused Eestis 2001-2004; keskmised IT eelarved Eestis 2001-2004

  18. Condor's biggest threat A California Condor's dinner in the wild is ...

    now condor protectionists are trying to persuade hunters to switch voluntarily to condor-safe lead-free bullets. The. Arizona Game and Fish Department has pioneered a program that distributes free copper bullets to hunters, and environmentalists are trying to convince hunters that lead bullets threaten not only condors but ...

  19. Changes in a temperate estuary during the filling of the biggest European dam.

    Morais, Pedro; Chícharo, Maria Alexandra; Chícharo, Luís

    2009-03-15

    This study aimed to determine whether and how the disruption of river flow, during the filling of the Alqueva dam, influenced the variability of abiotic and biotic factors in the Guadiana estuary, particularly the abundance and distribution of anchovy eggs. River inflow was found to be the most important factor in determining abiotic and biotic variability in the Guadiana estuary. Seasonal patterns were obscured by long periods of low inflow (mid April to early December 2002), which caused marked changes in the estuary. The estuarine turbidity maximum zone was displaced towards the upper estuary, to at least 38 km from the river mouth, 8 to 16 km upstream from previous records. The dynamics of nutrient stoichiometry was also affected. In the upper and middle estuary, P was more potential limiting than N and potential Si limitation was only frequent on the coast, with direct and/or indirect influence in changing phytoplankton dynamics and composition. Previously, the upper estuary alternated between potential P limitation during winter, Si limitation during spring and mid summer and N limitation during mid summer and autumn. The flooding of vast areas in the catchment of the dam probably caused the increase of DSi concentrations, as well as maximal N and P loadings. The abundance of larval stages of anchovy decreased, putatively because estuarine productivity has also decreased. In April 2002 there was an uncontrolled discharge from the Alqueva dam, which reduced the abundance of anchovy eggs by 99.99%. It is suggested that dam managers should mimic, as much as possible, the natural river flow, in order to minimize the impact on downstream ecosystems. Management efforts should not be restricted to the areas upstream of the dam, but should also encompass the estuary and adjacent coastal area.

  20. The Biggest Plates on Earth. Submarine Ring of Fire--Grades 5-6. Plate Tectonics.

    National Oceanic and Atmospheric Administration (DOC), Rockville, MD.

    This activity is designed to teach how tectonic plates move, what some consequences of this motion are, and how magnetic anomalies document the motion at spreading centers do. The activity provides learning objectives, a list of needed materials, key vocabulary words, background information, day-to-day procedures, internet connections, career…

  1. Is container type the biggest predictor of trace element and BPA leaching from drinking water bottles?

    Rowell, Candace; Kuiper, Nora; Preud'Homme, Hugues

    2016-07-01

    The knowledge-base of bottled water leachate is highly contradictory due to varying methodologies and limited multi-elemental and/or molecular analyses; understanding the range of contaminants and their pathways is required. This study determined the leaching potential and leaching kinetics of trace elements, using consistent comprehensive quantitative and semi-quantitative (79 elements total) analyses, and BPA, using isotopic dilution and MEPS pre-concentration with UHPLC-ESI-QTOF. Statistical methods were used to determine confounders and predictors of leaching and human health risk throughout 12days of UV exposure and after exposure to elevated temperature. Various types of water were used to assess the impact of water quality. Results suggest Sb leaching is primarily dependent upon water quality, not container type. Bottle type is a predictor of elemental leaching for Pb, Ba, Cr, Cu, Mn and Sr; BPA was detected in samples from polycarbonate containers. Health risks from the consumption of bottled water increase after UV exposure. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. BIG PLAY. Hospitals team up with biggest names in pro sports to score brand awareness.

    Robeznieks, Andis

    2016-07-01

    Partnering with major league baseball, basketball, hockey, football and even lacrosse teams isn't just about building brand recognition. It's also a way to promote health and fitness in the community.

  3. Imaging and Diagnosis: Using Imaging to Fight the World’S Biggest Killers

    Madsen, Michael

    2013-01-01

    Modern medicine has developed techniques and cures for many of humanity’s ailments, treatments that often require early detection or frequent observations. Some of the most revolutionary advances in improving diagnosis and observation of diseases have been through the use of imaging. Radioisotope imaging techniques like SPECT, PET/CT and conventional imaging such as MRI and CT are instrumental in fighting modern diseases like cardiovascular disease and cancer, and the IAEA plays an important role in helping its Member States acquire the skills and resources for implementing these technologies

  4. 'The biggest legal battle in UK casino history': Processes and politics of 'cheating' in sociotechnical networks.

    Johnson, Mark R

    2018-04-01

    Previous literature on cheating has focused on defining the concept, assigning responsibility to individual players, collaborative social processes or technical faults in a game's rules. By contrast, this paper applies an actor-network perspective to understanding 'cheating' in games, and explores how the concept is rhetorically effective in sociotechnical controversies. The article identifies human and nonhuman actors whose interests and properties were translated in a case study of 'edge sorting' - identifying minor but crucial differences in tessellated patterns on the backs of playing cards, and using these to estimate their values. In the ensuing legal controversy, the defending actors - casinos - retranslated the interests of actors to position edge sorting as cheating. This allowed the casinos to emerge victorious in a legal battle over almost twenty million dollars. Analyzing this dispute shows that cheating is both sociotechnically complex as an act and an extremely powerful rhetorical tool for actors seeking to prevent changes to previously-established networks. Science and Technology Studies (STS) offers a rich toolkit for examining cheating, but in addition the cheating discourse may be valuable to STS, enlarging our repertoire of actor strategies relevant to sociotechnical disputes.

  5. Freshwater ecosystems could become the biggest losers of the Paris Agreement.

    Hermoso, Virgilio

    2017-09-01

    Securing access to energy for a growing population under the international commitment of reduction of greenhouse emissions requires increasing the contribution of renewable sources to the global share. Hydropower energy, which accounts for >80% of green energy, is experiencing a boom fostered by international investment mainly in developing countries. This boom could be further accelerated by the recent climate agreement reached in Paris. Despite its flexibility, hydropower production entails social, economic and ecological risks that need to be carefully considered before investing in the development of potentially thousands of planned hydropower projects worldwide. This is especially relevant given the weak or nonexistent legislation that regulates hydropower project approval and construction in many countries. I highlight the need for adequate policy to provide the Paris Agreement with new financial and planning mechanisms to avoid further and irreversible damage to freshwater ecosystem services and biodiversity. © 2017 John Wiley & Sons Ltd.

  6. A Promising Approach to Addressing America's Biggest Challenges. Needle-Moving Community Collaboratives

    Jolin, Michele; Schmitz, Paul; Seldon, Willa

    2012-01-01

    Communities face powerful challenges--a high-school dropout epidemic, youth unemployment, teen pregnancy--that require powerful solutions. In a climate of increasingly constrained resources, those solutions must help communities to achieve more with less. A new kind of community collaborative--an approach that aspires to significant,…

  7. The Biggest Loser Thinks Long-Term: Recency as a Predictor of Success in Weight Management.

    Koritzky, Gilly; Rice, Chantelle; Dieterle, Camille; Bechara, Antoine

    2015-01-01

    Only a minority of participants in behavioral weight management lose weight significantly. The ability to predict who is likely to benefit from weight management can improve the efficiency of obesity treatment. Identifying predictors of weight loss can also reveal potential ways to improve existing treatments. We propose a neuro-psychological model that is focused on recency: the reliance on recent information at the expense of time-distant information. Forty-four weight-management patients completed a decision-making task and their recency level was estimated by a mathematical model. Impulsivity and risk-taking were also measured for comparison. Weight loss was measured in the end of the 16-week intervention. Consistent with our hypothesis, successful dieters (n = 12) had lower recency scores than unsuccessful ones (n = 32; p = 0.006). Successful and unsuccessful dieters were similar in their demographics, intelligence, risk taking, impulsivity, and delay of gratification. We conclude that dieters who process time-distant information in their decision making are more likely to lose weight than those who are high in recency. We argue that having low recency facilitates future-oriented thinking, and thereby contributes to behavior change treatment adherence. Our findings underline the importance of choosing the right treatment for every individual, and outline a way to improve weight-management processes for more patients.

  8. The Biggest Loser Thinks Long-Term: Recency as a Predictor of Success in Weight Management

    Gilly eKoritzky

    2015-12-01

    Full Text Available Only a minority of participants in behavioral weight management lose weight significantly. The ability to predict who is likely to benefit from weight management can improve the efficiency of obesity treatment. Identifying predictors of weight loss can also reveal potential ways to improve existing treatments. We propose a neuro-psychological model that is focused on recency: the reliance on recent information at the expense of time-distant information. Forty-four weight-management patients completed a decision-making task and their recency level was estimated by a mathematical model. Impulsivity and risk-taking were also measured for comparison. Weight loss was measured in the end of the 16-week intervention. Consistent with our hypothesis, successful dieters (n=12 had lower recency scores than unsuccessful ones (n=32; p=0.006. Successful and unsuccessful dieters were similar in their demographics, intelligence, risk taking, impulsivity, and delay of gratification. We conclude that dieters who process time-distant information in their decision making are more likely to lose weight than those who are high in recency. We argue that having low recency facilitates future-oriented thinking, and thereby contributes to behavior change treatment adherence. Our findings underline the importance of choosing the right treatment for every individual, and outline a way to improve weight-management processes for more patients.

  9. Personal View Climate change as the biggest threat to public health ...

    Adaptation: Reducing the risk. Some impacts of ... from their courses due to financial difficulties or family background. ... pharmacists, clinical officers, and health managers through ... Climate risk and vulnerability: a handbook for. Southern ...

  10. Truly yours, your biggest fan, this is Stan. Dramaturgi, remediering og iscenesettelse hos Eminem

    Dyndahl, Petter

    2003-01-01

    Dette essayet presenterer en medieteoretisk og populærmusikalsk analyse av Eminem og hans låt "Stan" fra albumet The Marshall Mathers LP, utgitt i 2000. Denne låten danner et samlende fokus for teoretiske og analytiske drøftinger omkring digital dramaturgi, remediering og mediert iscenesettelse. Notatet er første publiserte dokumentasjon av forskningsresultater fra prosjektet Gjenbruk og originalitet, som drives ved med støtte fra Prokom - Program for satsing på kommunikasjo...

  11. Addressing the Biggest (Baddest) and Best Ideas Ever: Through the Lens of Humility

    Sowcik, Matthew J.; Andenoro, Anthony C.; Council, Austin

    2017-01-01

    Now and into the foreseeable future, both effective leadership and creativity are going to be important when addressing complex problems. The connection between effective leadership and creativity will be critical as leaders look to turn big ideas into innovative solutions. However, it seems that there is often a disconnect between the two…

  12. Urban violence is the biggest cause of fatal work-related accidents in Brazil.

    Cordeiro, Ricardo; Luz, Verônica Gronau; Hennington, Élida Azevedo; Martins, Ana Cláudia Alves; Tófoli, Luís Fernando

    2017-12-11

    To quantify the occurrence of deaths directly associated with urban violence among fatal work-related accidents. Verbal autopsies were performed with the relatives and coworkers of residents of Campinas, state of São Paulo, Brazil, who died from external causes in 2015. We have also analyzed police reports and reports of the Legal Medical Institute related to these deaths. We have identified 82 fatal work-related accidents in Campinas in 2015, of which 25 were murders, 35 were traffic accidents not directly related to work activities, and three were suicides at work. The proportional mortality rate for homicides, traffic accidents, and suicides among fatal work-related accidents was estimated at 30.5%, 42.7%, and 3.7%, respectively. Urban violence accounted for three-fourths of the fatal work-related accidents recorded in the period studied.

  13. A Study of The Best Selling Smartphone in The Two Biggest Marketplace in Indonesia

    Alfian Budi Primanto

    2018-03-01

    Full Text Available The number of entrepreneurs in Indonesia has increased significantly in the past decade. Many entrepreneurs expand their business into digital by using marketplace platform. Although, there are a lot of entrepreneur use digital landscape to scale up their business, many online business ended in failure. This research aims to answer the following questions; what is the success factor of smartphone campaign in the Indonesia marketplace platform? Is there any difference success factor between each marketplace platform? The researcher uses secondary data, simple random sampling, and binary logistic regression modeling for the purpose to answer research questions. Interestingly, this research shows that there are no relationship between seller reputation and sales acquirement. Also, there is no difference behaviour between each marketplace platform. Therefore, to be succeed in marketplace competition, each seller should pay attention to their price competitiveness while at the same time find the best option to increases their number of store page views.

  14. The biggest bio-fuel plant in Norway - a profitable environmental investment

    Lind, Oddvar

    2002-01-01

    A few years ago, Norske Skog Saugbrugs in Halden, Norway, invested NOK 180 mill in a new combustion plant for bio-fuel. In 2001, the plant produced 400 GWh and so replaced about 35 000 tonnes of oil. Considering the Kyoto Agreement, the profitability is even greater. The capacity of the boiler is 400 - 450 GWh, which covers more than 40 percent of the paper factory's need for thermal energy. The paper factory in Halden is one of the largest in Europe. About half of the bio-fuel derives from the factory's own production, which is an important reason why the price of bio-energy is less than the price of oil. At the same time the use of the biomass for energy production implies that bark and mud does not pile up in the factory. The remaining half of the biomass, the external half, is wood returned from building activities in the form of wood chippings, one-time pallets and similar. This also solves a social problem. The bio-fuel plant uses a fluidized bed boiler of very high efficiency. This implies very small emissions of NOx and CO. Particles are removed by means of an electro filter. The system meets the requirements made by the EU and by Norwegian pollution control authorities

  15. Pallet Users State Their Preferences For Used Pallets - Companion Stringers Cited as Biggest

    Robert J. Bush; Ronen Roudik; Philip A. Araman

    1995-01-01

    A study recently completed by VA Tech in Blacksburg, VA, found that half companion stringers have the greatest negative impact on purchasers of used pallets, followed by split deckboards, protruding nails, and full companion stringers. Repairs using metal plates had relatively little affect on the value of the pallet. The study provides new information concerning the...

  16. The biggest stone anchors (Indo-Arab type) from Mithi Virdi, Bhavnagar, west coast of India

    Gaur, A.S.; Sundaresh; Kumar, B.

    of Oceanography, Goa on the Saurashtra coast have been undertaken at Dwarka (Gaur et al. 2000), Bet Dwarka (Sundaresh et al. 2002) and Somnath {Gaur et al. 2002). The prospections *National Institute of Oceanography, Dona Paula, Goa **Devli, Talaza, Bhavnagar... of stone anchors at Dwarka, Bet Dwarka, Aramda (Gaur et al. 2003), Somnath (Gaur ef al. 2002), Vijayadurg (Sila ef al. 1998), Sindhudurg (Sila and Gaur 1997), Goa waters (Sila et al. 2003) and Tamilnadu coast (Athiyaman 2001). These anchors...

  17. Is the Biggest Paradigm Shift in the History of Science at Hand?

    Gaastra E.

    2005-10-01

    Full Text Available According to a growing number of scientists cosmology is at the end of an era. This era started 100 years ago with the publication of Albert Einstein’s special theory of relativity and came to its height in the 1920s when the theory of relativity was used to develop the big bang model. However, at this moment there is a crisis within cosmology. More and more scientists openly doubt the big bang. There are alternatives for the theory of relativity as well as for the big bang model, but so far most scientists are scared to pass over Einstein.

  18. Can the biggest experiment ever tell us how the universe works?

    Eddy, Ian

    2008-01-01

    Wednesday 10 September will be a massive day for science and mankind. On that day, the largest machine ever built will begin an experiment to recreate the conditions that existed close to the dawn of time. Scientists hope that it will vastly improve our knowledge of the universe. (2 pages)

  19. Can the biggest experiment ever tell us how the universe works?

    Eddy, Ian

    2008-01-01

    10 September will be a massive day for science and mankind. On that day, the largest machine ever built will begin an experiment to recreate the conditions that existed close to the dawn of time. Scientists hope that it will vastly improve our knowledge of the universe. (1 page)

  20. Enabling Data-as- a-Service (DaaS) - Biggest Challenge of Geoscience Australia

    Bastrakova, I.; Kemp, C.; Car, N. J.

    2016-12-01

    Geoscience Australia (GA) is recognised and respected as the national repository and steward of multiple national significance data collections that provides geoscience information, services and capability to the Australian Government, industry and stakeholders. Provision of Data-as-a-Service is both GA's key responsibility and core business. Through the Science First Transformation Program GA is undergoing a significant rethinking of its data architecture, curation and access to support the Digital Science capability for which DaaS forms both a dependency and underpins its implementation. DaaS, being a service, means we can deliver its outputs in multiple ways thus providing users with data on demand in ready-for-consumption forms. We can then to reuse prebuilt data constructions to allow self-serviced integration of data underpinned by dynamic query tools. In GA's context examples of DaaS are the Australian Geoscience Data Cube, the Foundation Spatial Data Framework and data served through several Virtual Laboratories. We have implemented a three-layered architecture for DaaS in order to store and manage the data while honouring the semantics of Scientific Data Models defined by subject matter experts and GA's Enterprise Data Architecture as well as retain that delivery flexibility. The foundation layer of DaaS is Canonical Datasets, which are optimised for a long-term data stewardship and curation. Data is well structured, standardised, described and audited. All data creation and editing happen within this layer. The middle Data Transformation layer assists with transformation of data from Canonical Datasets to data integration layer. It provides mechanisms for multi-format and multi-technology data transformation. The top Data Integration layer is optimised for data access. Data can be easily reused and repurposed; data formats made available are optimised for scientific computing and adjusted for access by multiple applications, tools and libraries. Moving to DaaS enables GA to increase data alertness, generate new capabilities and be prepared for emerging technological challengers.

  1. Biodiversity and Land uses at a regional scale: Is agriculture the biggest threat for reptile assemblages?

    Ribeiro, Raquel; Santos, Xavier; Sillero, Neftali; Carretero, Miguel A.; Llorente, Gustavo A.

    2009-03-01

    The human exploitation of land resources (land use) has been considered the major factor responsible for changes in biodiversity within terrestrial ecosystems given that it affects directly the distribution of the fauna. Reptiles are known to be particularly sensitive to habitat change due to their ecological constraints. Here, the impact of land use on reptile diversity was analysed, choosing Catalonia (NE Iberia) as a case study. This region provides a suitable scenario for such a biogeographical study since it harbours: 1) a rich reptile fauna; 2) a highly diverse environment showing strong variation in those variables usually shaping reptile distributions; and 3) good species distribution data. Potential species richness was calculated, using ecological modelling techniques (Ecological Niche Factor Analysis - ENFA). The subtraction of the observed from the potential species richness was the dependent variable in a backwards multiple linear regression, using land use variables. Agriculture was the land use with the strongest relation with the non-fulfilment of the potential species richness, indicating a trend towards a deficit of biodiversity. Deciduous forest was the only land use negatively related with the subtracted species richness. Results indicate a clear relationship between land use and biodiversity at a mesoscale. This finding represents an important baseline for conservation guidelines within the habitat change framework because it has been achieved at the same spatial scale of chorological studies and management policies.

  2. The world’s biggest hotel companies. Old trends and new tendencies

    Kowalczyk Andrzej

    2015-12-01

    Full Text Available Many hotels are owned by a few dozen so-called hotel chains or hotel systems. The rapid growth of big hotel companies can be regarded as proof of the entrance of hotel systems into the globalisation phase. Since 2006, companies from the People’s Republic of China (PRC have been among the world’s top hotel systems. This year can be considered as the symbolic beginning of a new stage in the history of the largest hotel systems. This paper shows two main trends. On the one hand, the processes that could be observed in the market of the major global hotel systems from the 1990s are still discernible (for example, the position of the so-called hotel megasystems. On the other hand, new trends have come to the fore in recent years, notably the emergence of systems from the People’s Republic of China among the world’s largest hotel systems.

  3. Urban violence is the biggest cause of fatal work-related accidents in Brazil

    Cordeiro, Ricardo; Luz, Verônica Gronau; Hennington, Élida Azevedo; Martins, Ana Cláudia Alves; Tófoli, Luís Fernando

    2017-01-01

    ABSTRACT OBJECTIVE To quantify the occurrence of deaths directly associated with urban violence among fatal work-related accidents. METHODS Verbal autopsies were performed with the relatives and coworkers of residents of Campinas, state of São Paulo, Brazil, who died from external causes in 2015. We have also analyzed police reports and reports of the Legal Medical Institute related to these deaths. RESULTS We have identified 82 fatal work-related accidents in Campinas in 2015, of which 25...

  4. The Biggest Aspidistra in the World; A Personal Celebration of Fifty Years of the BBC.

    Black, Peter

    This book is a personal recollection of the history of the British Broadcasting Corporation (BBC), written as a celebration of the BBC's fiftieth anniversary in 1972. The emphasis is on programs and people rather than policies. It is divided into roughly three periods: prewar, war, and postwar. The author writes, "The object is to remind…

  5. The biggest fish in the sea? Dynamic Kenyan labour migration in the East African community

    Ong'ayo, A.O.O.; Oucho, J.O.; Oucho, L.A.

    2013-01-01

    This study assesses the Kenyan policy and institutional framework concerning South–South labour migration with particular focus on the East African Community (EAC) countries. It focuses mainly on one particular policy instrument, the East African Community Common Market framework. The research

  6. In Sweden, big business is the biggest customer of LP firms

    Clark, W.W.

    1992-01-01

    This paper reports that unwittingly, in all likelihood, big brother natural gas, which so often proves detrimental to the interests of LPG marketers by moving into their long-established territories, has actually proven a double-barreled boon in Sweden. On the one hand it has made the national LPG-conscious. On the other hand, because of the sparseness of the population its market area is limited to the western edge of the country as it is not a competitor, nor is it likely to become one in the foreseeable future. It was the introduction of natural gas that gave a healthy boost to LPG's fortune in 1985. In the following year, the market, which had been essentially flat since 1975, suddenly began to expand, and it continued to do so through 1990. Since then, however, it has once again flattened out because of the worldwide recession, from which not nation is totally immune

  7. Flow and turbulence structure in a hypertidal estuary with the world's biggest tidal bore

    Tu, Junbiao; Fan, Daidu

    2017-04-01

    Turbulent and flow structure associated with breaking tidal bores are deliberately investigated on the basis of field measurements. High-resolution velocity and hydrographic data are collected in the middle Qiantang Estuary by a vertical array of acoustic Doppler velocimeters and optical backscatter sensors, collaborated with a bottom-mounted acoustic Doppler current profiler. Besides obvious variations in diurnal and spring-neap tidal cycles, the estuarine dynamics is featured by extreme asymmetry in flood and ebb tides. The flood tide is abnormally accelerated to generate tidal bores at the first 10 min or more, with breaking or undular configurations at the front. The occurrence of peak flow velocity, turbulent kinetic energy (TKE), and TKE dissipation rate (ɛ) is definitely associated with breaking bores, with their values several times to 2 orders of magnitude larger than the corresponding secondary peak values during the maximum ebb flows. Flow and turbulence dynamics are significantly affected by the tidal-bore Froude number. A sandwich ɛ structure is clear exhibited with the maximum value at the surface, secondary maximum near the bed, and the minimum at the intermediate. Dual TKE sources are indicated by an approximate local balance between shear production and dissipation near the bottom, and a top-down TKE dissipation using the modified Froude scaling in the vertical water column. The highly elevated dissipation by breaking bores is comparable to that by intense breaking waves in the surf zone, and the former potentially penetrates the entire water column to produce extreme sediment-resuspension events in combination with intense bottom shear stress.

  8. The Promise of Single-Sex Classes

    Stotsky, Sandra

    2012-01-01

    Despite the enthusiasm and the absence of definitive research on the pros and cons of single-sex classes, a 2011 article in Science, titled "The Pseudoscience of Single-Sex Schooling," by a new organization called American Council for CoEducational Schooling (ACCES) came out with the astonishing conclusion that single-sex education is…

  9. The Advantages of Single-Sex Education

    Hughes, Teresa A.

    2006-01-01

    Traditionally, single-sex education has been provided in the form of private schooling. Title IX regulations have loosened as a result of the No Child Left Behind Legislation; therefore, public school districts now have the legal right to create single-sex classes or single-sex schools if they deem it to be in the best interest of their students.…

  10. Single chip camera active pixel sensor

    Shaw, Timothy (Inventor); Pain, Bedabrata (Inventor); Olson, Brita (Inventor); Nixon, Robert H. (Inventor); Fossum, Eric R. (Inventor); Panicacci, Roger A. (Inventor); Mansoorian, Barmak (Inventor)

    2003-01-01

    A totally digital single chip camera includes communications to operate most of its structure in serial communication mode. The digital single chip camera include a D/A converter for converting an input digital word into an analog reference signal. The chip includes all of the necessary circuitry for operating the chip using a single pin.

  11. Single Subject Research: Applications to Special Education

    Cakiroglu, Orhan

    2012-01-01

    Single subject research is a scientific research methodology that is increasingly used in the field of special education. Therefore, understanding the unique characteristics of single subject research methodology is critical both for educators and practitioners. Certain characteristics make single subject research one of the most preferred…

  12. Single-Parent Families in Rural Communities

    Lewis, Ken

    1978-01-01

    Presenting national statistics on single-parent families, this article illustrates the need for serious study of this phenomenon, suggesting that changing divorce laws, increased single-parent adoptions, and an increase in the number of supportive services for single-parent families are contingencies having significant bearing upon the…

  13. Single Particle Entropy in Heated Nuclei

    Guttormsen, M.; Chankova, R.; Hjorth-Jensen, M.; Rekstad, J.; Siem, S.; Sunde, A. C.; Syed, N. U. H.; Agvaanluvsan, U.; Schiller, A.; Voinov, A.

    2006-01-01

    The thermal motion of single particles represents the largest contribution to level density (or entropy) in atomic nuclei. The concept of single particle entropy is presented and shown to be an approximate extensive (additive) quantity for mid-shell nuclei. A few applications of single particle entropy are demonstrated

  14. Single conversion stage amplifier - SICAM

    Ljusev, P.

    2005-12-15

    This Ph.D. thesis presents a thorough analysis of the so called SICAM - SIngle Converter stage AMplifier approach to building direct energy conversion audio power amplifiers. The mainstream approach for building isolated audio power amplifiers today consists of isolated DC power supply and Class D amplifier, which essentially represents a two stage solution, where each of the components can be viewed as separate and independent part. The proposed SICAM solution strives for direct energy conversion from the mains to the audio output, by dedicating the operation of the components one to another and integrating their functions, so that the final audio power amplifier represents a single-stage topology with higher efficiency, lower volume, less board space, lower component count and subsequently lower cost. The SICAM approach is both applicable to non-isolated and isolated audio power amplifiers, but the problems encountered in these two cases are different. Non-isolated SICAM solutions are intended for both AC mains-connected and battery-powered devices. In non-isolated mains-connected SICAMs the main idea is to simplify the power supply or even provide integrated power factor correction (PFC) functions, while still maintaining low component stress and good audio performance by generally decreasing the input voltage level to the Class D audio power amplifier. On the other hand, non-isolated battery-powered SICAMs have to cope with the ever changing battery voltage and provide output voltage levels which are both lower and higher than the battery voltage, while still being simple and single-stage energy conversion solutions. In isolated SICAMs the isolation transformer adjusts the voltage level on the secondary side to the desired level, so the main challenges here are decreasing the size of the magnetic core and reducing the number and size of bulky reactive components as much as possible. The main focus of this thesis is directed towards the isolated SICAMs and

  15. Prions: Beyond a Single Protein

    Das, Alvin S.

    2016-01-01

    SUMMARY Since the term protein was first coined in 1838 and protein was discovered to be the essential component of fibrin and albumin, all cellular proteins were presumed to play beneficial roles in plants and mammals. However, in 1967, Griffith proposed that proteins could be infectious pathogens and postulated their involvement in scrapie, a universally fatal transmissible spongiform encephalopathy in goats and sheep. Nevertheless, this novel hypothesis had not been evidenced until 1982, when Prusiner and coworkers purified infectious particles from scrapie-infected hamster brains and demonstrated that they consisted of a specific protein that he called a “prion.” Unprecedentedly, the infectious prion pathogen is actually derived from its endogenous cellular form in the central nervous system. Unlike other infectious agents, such as bacteria, viruses, and fungi, prions do not contain genetic materials such as DNA or RNA. The unique traits and genetic information of prions are believed to be encoded within the conformational structure and posttranslational modifications of the proteins. Remarkably, prion-like behavior has been recently observed in other cellular proteins—not only in pathogenic roles but also serving physiological functions. The significance of these fascinating developments in prion biology is far beyond the scope of a single cellular protein and its related disease. PMID:27226089

  16. Nonlinear Single Spin Spectrum Analayzer

    Kotler, Shlomi; Akerman, Nitzan; Glickman, Yinnon; Ozeri, Roee

    2014-05-01

    Qubits are excellent probes of their environment. When operating in the linear regime, they can be used as linear spectrum analyzers of the noise processes surrounding them. These methods fail for strong non-Gaussian noise where the qubit response is no longer linear. Here we solve the problem of nonlinear spectral analysis, required for strongly coupled environments. Our non-perturbative analytic model shows a nonlinear signal dependence on noise power, resulting in a spectral resolution beyond the Fourier limit as well as frequency mixing. We developed a noise characterization scheme adapted to this non-linearity. We then applied it using a single trapped 88Sr+ ion as the a sensitive probe of strong, non-Gaussian, discrete magnetic field noise. With this method, we attained a ten fold improvement over the standard Fourier limit. Finally, we experimentally compared the performance of equidistant vs. Uhrig modulation schemes for spectral analysis. Phys. Rev. Lett. 110, 110503 (2013), Synopsis at http://physics.aps.org/synopsis-for/10.1103/PhysRevLett.110.110503 Current position: National Institute of Standards and Tehcnology, Boulder, CO.

  17. Crystal ball single event display

    Grosnick, D.; Gibson, A.; Allgower, C.; Alyea, J.; Argonne National Lab., IL

    1997-01-01

    The Single Event Display (SED) is a routine that is designed to provide information graphically about a triggered event within the Crystal Ball. The SED is written entirely in FORTRAN and uses the CERN-based HICZ graphing package. The primary display shows the amount of energy deposited in each of the NaI crystals on a Mercator-like projection of the crystals. Ten different shades and colors correspond to varying amounts of energy deposited within a crystal. Information about energy clusters is displayed on the crystal map by outlining in red the thirteen (or twelve) crystals contained within a cluster and assigning each cluster a number. Additional information about energy clusters is provided in a series of boxes containing useful data about the energy distribution among the crystals within the cluster. Other information shown on the event display include the event trigger type and data about π o 's and η's formed from pairs of clusters as found by the analyzer. A description of the major features is given, along with some information on how to install the SED into the analyzer

  18. Measurements of Nascent Soot Using a Cavity Attenauted Phase Shift (CAPS)-based Single Scattering Albedo Monitor

    Freedman, A.; Onasch, T. B.; Renbaum-Wollf, L.; Lambe, A. T.; Davidovits, P.; Kebabian, P. L.

    2015-12-01

    Accurate, as compared to precise, measurement of aerosol absorption has always posed a significant problem for the particle radiative properties community. Filter-based instruments do not actually measure absorption but rather light transmission through the filter; absorption must be derived from this data using multiple corrections. The potential for matrix-induced effects is also great for organic-laden aerosols. The introduction of true in situ measurement instruments using photoacoustic or photothermal interferometric techniques represents a significant advance in the state-of-the-art. However, measurement artifacts caused by changes in humidity still represent a significant hurdle as does the lack of a good calibration standard at most measurement wavelengths. And, in the absence of any particle-based absorption standard, there is no way to demonstrate any real level of accuracy. We, along with others, have proposed that under the circumstance of low single scattering albedo (SSA), absorption is best determined by difference using measurement of total extinction and scattering. We discuss a robust, compact, field deployable instrument (the CAPS PMssa) that simultaneously measures airborne particle light extinction and scattering coefficients and thus the single scattering albedo (SSA) on the same sample volume. The extinction measurement is based on cavity attenuated phase shift (CAPS) techniques as employed in the CAPS PMex particle extinction monitor; scattering is measured using integrating nephelometry by incorporating a Lambertian integrating sphere within the sample cell. The scattering measurement is calibrated using the extinction measurement of non-absorbing particles. For small particles and low SSA, absorption can be measured with an accuracy of 6-8% at absorption levels as low as a few Mm-1. We present new results of the measurement of the mass absorption coefficient (MAC) of soot generated by an inverted methane diffusion flame at 630 nm. A value

  19. Single-Organ Gallbladder Vasculitis

    Hernández-Rodríguez, José; Tan, Carmela D.; Rodríguez, E. René; Hoffman, Gary S.

    2014-01-01

    Abstract Systemic vasculitis (SV) involving abdominal structures usually has a poor prognosis. Gallbladder vasculitis (GV) has been reported as part of SV (GB-SV) and focal single-organ vasculitis (GB-SOV). We analyzed clinical and histologic characteristics of patients with GV to identify features that differentiate GB-SOV from the systemic forms of GV. To identify affected patients with GV we used pathology databases from our institution and an English-language PubMed search. Clinical manifestations, laboratory and histologic features, treatment administered, and outcomes were recorded. Patients were divided in 2 groups, GB-SOV and GB-SV. As in previous studies of single-organ vasculitis, GB-SOV was only considered to be a sustainable diagnosis if disease beyond the gallbladder was not apparent after a follow-up period of at least 6 months. Sixty-one well-characterized patients with GV were included (6 from our institution). There was no significant sex bias (32 female patients, 29 male). Median age was 52 years (range, 18–94 yr). GB-SOV was found in 20 (33%) and GB-SV in 41 (67%) patients. No differences were observed in age, sex frequency, or duration of gallbladder symptoms between groups. Past episodes of recurrent right-upper quadrant or abdominal pain and lithiasic cholecystitis were more frequent in GB-SOV patients, whereas acalculous cholecystitis occurred more often in GB-SV. In GB-SV, gallbladder-related symptoms occurred more often concomitantly with or after the systemic features, but they sometimes appeared before SV was fully developed (13.5%). Constitutional and musculoskeletal symptoms were reported only in GB-SV patients. Compared to GB-SOV, GB-SV patients presented more often with fever (62.5% vs 20%; p = 0.003) and exhibited higher erythrocyte sedimentation rate levels (80 ± 28 vs 37 ± 25 mm/h, respectively; p = 0.006). All GB-SV patients required glucocorticoids and 50% of them also received cytotoxic agents. Mortality in

  20. Tailoring single-photon and multiphoton probabilities of a single-photon on-demand source

    Migdall, A.L.; Branning, D.; Castelletto, S.

    2002-01-01

    As typically implemented, single-photon sources cannot be made to produce single photons with high probability, while simultaneously suppressing the probability of yielding two or more photons. Because of this, single-photon sources cannot really produce single photons on demand. We describe a multiplexed system that allows the probabilities of producing one and more photons to be adjusted independently, enabling a much better approximation of a source of single photons on demand

  1. Laparoendoscopic single site (LESS) cholecystectomy.

    Hodgett, Steven E; Hernandez, Jonathan M; Morton, Connor A; Ross, Sharona B; Albrink, Michael; Rosemurgy, Alexander S

    2009-02-01

    The journey from conventional "open" operations to truly "minimally invasive" operations naturally includes progression from operations involving multiple trocars and multiple incisions to operations involving access through the umbilicus alone. Laparoscopic operations through the umbilicus alone, laparoendoscopic single site surgery (LESS), offer improved cosmesis and hopes for less pain and improved recovery. This study was undertaken to evaluate our initial experience with LESS cholecystectomy and to compare our initial experience to concurrent outcomes with more conventional multiport, multi-incision laparoscopic cholecystectomy. All patients referred for cholecystectomy over a 6-month period were offered LESS. Outcomes, including blood loss, operative time, complications, and length of stay were recorded. Outcomes with our first LESS cholecystectomies were compared to an uncontrolled group of concurrent patients undergoing multiport, multi-incision laparoscopic cholecystectomy at the same hospital by the same surgeon. Twenty-nine patients of median age 50 years undergoing LESS cholecystectomy from November 2007 until May 2008 were compared to 29* patients, median age 48 years, undergoing standard multiport, multiple-incision laparoscopic cholecystectomy over the same time period. Median operative time for patients undergoing LESS cholecystectomy was 72 min and was not different from that of patients undergoing multiport, multi-incision laparoscopic cholecystectomy (p = 0.81). Median length of hospital stay was 1.0 day for patients undergoing LESS cholecystectomy and was not different from patients undergoing standard laparoscopic cholecystectomy (p = 0.46). Operative estimated blood loss was less than 100 cc for all patients. No patients undergoing attempted LESS cholecystectomy had conversions to "open" operations; two patients had an additional trocar(s) placed distant from the umbilicus to aid in exposure. Three patients undergoing LESS cholecystectomy had

  2. Single Cell Assay for Analyzing Single Cell Exosome and Endocrine Secretion and Cancer Markers

    Chiu, Yu-Jui

    To understand the inhomogeneity of cells in biological systems, there is a growing demand for the capability to characterize the properties of individual single cells. Since single cell studies require continuous monitoring of the cell behaviors instead of a snapshot test at a single time point, an effective single-cell assay that can support time lapsed studies in a high throughput manner is desired. Most currently available single-cell technologies cannot provide proper environments to sustain cell growth and cannot provide, for appropriate cell types, proliferation of single cells and convenient, non-invasive tests of single cell behaviors from molecular markers. In this dissertation, I present a highly versatile single-cell assay that can accommodate different cellular types, enable easy and efficient single cell loading and culturing, and be suitable for the study of effects of in-vitro environmental factors in combination with drug screening. The salient features of the assay are the non-invasive collection and surveying of single cell secretions at different time points and massively parallel translocation of single cells by user defined criteria, producing very high compatibility to the downstream process such as single cell qPCR and sequencing. Above all, the acquired information is quantitative -- for example, one of the studies is measured by the number of exosomes each single cell secretes for a given time period. Therefore, our single-cell assay provides a convenient, low-cost, and enabling tool for quantitative, time lapsed studies of single cell properties.

  3. Telecentres: a one-stop communication shop | IDRC - International ...

    2011-07-12

    Jul 12, 2011 ... One of the reasons for its popularity, claims its 22-year old manager ... Its biggest hurdle is how best to translate that support into a stable, sustainable future. Plans are now underway here and in Namaacha to place telecentre ...

  4. Single Molecule Applications of Quantum Dots

    Rasmussen, Thomas Elmelund; Jauffred, Liselotte; Brewer, Jonathan R.

    2013-01-01

    Fluorescent nanocrystals composed of semiconductor materials were first introduced for biological applications in the late 1990s. The focus of this review is to give a brief survey of biological applications of quantum dots (QDs) at the single QD sensitivity level. These are described as follows: 1......) QD blinking and bleaching statistics, 2) the use of QDs in high speed single particle tracking with a special focus on how to design the biofunctional coatings of QDs which enable specific targeting to single proteins or lipids of interest, 3) a hybrid lipid-DNA analogue binding QDs which allows...... for tracking single lipids in lipid bilayers, 4) two-photon fluorescence correlation spectroscopy of QDs and 5) optical trapping and excitation of single QDs. In all of these applications, the focus is on the single particle sensitivity level of QDs. The high applicability of QDs in live cell imaging...

  5. Single molecule detection, thermal fluctuation and life

    YANAGIDA, Toshio; ISHII, Yoshiharu

    2017-01-01

    Single molecule detection has contributed to our understanding of the unique mechanisms of life. Unlike artificial man-made machines, biological molecular machines integrate thermal noises rather than avoid them. For example, single molecule detection has demonstrated that myosin motors undergo biased Brownian motion for stepwise movement and that single protein molecules spontaneously change their conformation, for switching to interactions with other proteins, in response to thermal fluctuation. Thus, molecular machines have flexibility and efficiency not seen in artificial machines. PMID:28190869

  6. Single cell enzyme diagnosis on the chip

    Jensen, Sissel Juul; Harmsen, Charlotte; Nielsen, Mette Juul

    2013-01-01

    Conventional diagnosis based on ensemble measurements often overlooks the variation among cells. Here, we present a droplet-microfluidics based platform to investigate single cell activities. Adopting a previously developed isothermal rolling circle amplification-based assay, we demonstrate...... detection of enzymatic activities down to the single cell level with small quantities of biological samples, which outcompetes existing techniques. Such a system, capable of resolving single cell activities, will ultimately have clinical applications in diagnosis, prediction of drug response and treatment...

  7. Search for Single Top Production at LEP

    Achard, P; Aguilar-Benítez, M; Alcaraz, J; Alemanni, G; Allaby, James V; Aloisio, A; Alviggi, M G; Anderhub, H; Andreev, V P; Anselmo, F; Arefev, A; Azemoon, T; Aziz, T; Bagnaia, P; Bajo, A; Baksay, G; Baksay, L; Baldew, S V; Banerjee, S; Banerjee, Sw; Barczyk, A; Barillère, R; Bartalini, P; Basile, M; Batalova, N; Battiston, R; Bay, A; Becattini, F; Becker, U; Behner, F; Bellucci, L; Berbeco, R; Berdugo, J; Berges, P; Bertucci, B; Betev, B L; Biasini, M; Biglietti, M; Biland, A; Blaising, J J; Blyth, S C; Bobbink, Gerjan J; Böhm, A; Boldizsar, L; Borgia, B; Bottai, S; Bourilkov, D; Bourquin, Maurice; Braccini, S; Branson, J G; Brochu, F; Burger, J D; Burger, W J; Cai, X D; Capell, M; Cara Romeo, G; Carlino, G; Cartacci, A M; Casaus, J; Cavallari, F; Cavallo, N; Cecchi, C; Cerrada, M; Chamizo-Llatas, M; Chang, Y H; Chemarin, M; Chen, A; Chen, G; Chen, G M; Chen, H F; Chen, H S; Chiefari, G; Cifarelli, Luisa; Cindolo, F; Clare, I; Clare, R; Coignet, G; Colino, N; Costantini, S; de la Cruz, B; Cucciarelli, S; van Dalen, J A; De Asmundis, R; Déglon, P L; Debreczeni, J; Degré, A; Dehmelt, K; Deiters, K; Della Volpe, D; Delmeire, E; Denes, P; De Notaristefani, F; De Salvo, A; Diemoz, M; Dierckxsens, M; Dionisi, C; Dittmar, M; Doria, A; Dova, M T; Duchesneau, D; Echenard, B; Eline, A; El-Mamouni, H; Engler, A; Eppling, F J; Ewers, A; Extermann, P; Falagán, M A; Falciano, S; Favara, A; Fay, J; Fedin, O; Felcini, M; Ferguson, T; Fesefeldt, H S; Fiandrini, E; Field, J H; Filthaut, Frank; Fisher, P H; Fisher, W; Fisk, I; Forconi, G; Freudenreich, Klaus; Furetta, C; Galaktionov, Yu; Ganguli, S N; García-Abia, P; Gataullin, M; Gentile, S; Giagu, S; Gong, Z F; Grenier, G; Grimm, O; Grünewald, M W; Guida, M; van Gulik, R; Gupta, V K; Gurtu, A; Gutay, L J; Haas, D; Hakobyan, R S; Hatzifotiadou, D; Hebbeker, T; Hervé, A; Hirschfelder, J; Hofer, H; Hohlmann, M; Holzner, G; Hou, S R; Hu, Y; Jin, B N; Jones, L W; de Jong, P; Josa-Mutuberria, I; Käfer, D; Kaur, M; Kienzle-Focacci, M N; Kim, J K; Kirkby, Jasper; Kittel, E W; Klimentov, A; König, A C; Kopal, M; Koutsenko, V F; Kräber, M H; Krämer, R W; Krenz, W; Krüger, A; Kunin, A; Ladrón de Guevara, P; Laktineh, I; Landi, G; Lebeau, M; Lebedev, A; Lebrun, P; Lecomte, P; Lecoq, P; Le Coultre, P; Le Goff, J M; Leiste, R; Levtchenko, M; Levchenko, P M; Li, C; Likhoded, S A; Lin, C H; Lin, W T; Linde, Frank L; Lista, L; Liu, Z A; Lohmann, W; Longo, E; Lü, Y S; Lübelsmeyer, K; Luci, C; Luminari, L; Lustermann, W; Ma Wen Gan; Malgeri, L; Malinin, A; Maña, C; Mangeol, D J J; Mans, J; Martin, J P; Marzano, F; Mazumdar, K; McNeil, R R; Mele, S; Merola, L; Meschini, M; Metzger, W J; Mihul, A; Milcent, H; Mirabelli, G; Mnich, J; Mohanty, G B; Muanza, G S; Muijs, A J M; Musicar, B; Musy, M; Nagy, S; Natale, S; Napolitano, M; Nessi-Tedaldi, F; Newman, H; Niessen, T; Nisati, A; Nowak, H; Ofierzynski, R A; Organtini, G; Palomares, C; Pandoulas, D; Paolucci, P; Paramatti, R; Passaleva, G; Patricelli, S; Paul, T; Pauluzzi, M; Paus, C; Pauss, Felicitas; Pedace, M; Pensotti, S; Perret-Gallix, D; Petersen, B; Piccolo, D; Pierella, F; Pioppi, M; Piroué, P A; Pistolesi, E; Plyaskin, V; Pohl, M; Pozhidaev, V; Pothier, J; Prokofiev, D O; Prokofev, D; Quartieri, J; Rahal-Callot, G; Rahaman, M A; Raics, P; Raja, N; Ramelli, R; Rancoita, P G; Ranieri, R; Raspereza, A V; Razis, P A; Ren, D; Rescigno, M; Reucroft, S; Riemann, S; Riles, K; Roe, B P; Romero, L; Rosca, A; Rosier-Lees, S; Roth, S; Rosenbleck, C; Roux, B; Rubio, Juan Antonio; Ruggiero, G; Rykaczewski, H; Sakharov, A; Saremi, S; Sarkar, S; Salicio, J; Sánchez, E; Sanders, M P; Schäfer, C; Shchegelskii, V; Schmidt-Kärst, S; Schmitz, D; Schopper, Herwig Franz; Schotanus, D J; Schwering, G; Sciacca, C; Servoli, L; Shevchenko, S; Shivarov, N; Shoutko, V; Shumilov, E; Shvorob, A V; Siedenburg, T; Son, D; Souga, C; Spillantini, P; Steuer, M; Stickland, D P; Stoyanov, B; Strässner, A; Sudhakar, K; Sultanov, G G; Sun, L Z; Sushkov, S V; Suter, H; Swain, J D; Szillási, Z; Tang, X W; Tarjan, P; Tauscher, Ludwig; Taylor, L; Tellili, B; Teyssier, D; Timmermans, C; Ting, Samuel C C; Ting, S M; Tonwar, S C; Tóth, J; Tully, C; Tung, K L; Ulbricht, J; Valente, E; Van de Walle, R T; Vásquez, R P; Veszpremi, V; Vesztergombi, G; Vetlitskii, I; Vicinanza, D; Viertel, Gert M; Villa, S; Vivargent, M; Vlachos, S; Vodopyanov, I; Vogel, H; Vogt, H; Vorobev, I; Vorobyov, A A; Wadhwa, M; Wallraff, W; Wang, X L; Wang, Z M; Weber, M; Wienemann, P; Wilkens, H; Wynhoff, S; Xia, L; Xu, Z Z; Yamamoto, J; Yang, B Z; Yang, C G; Yang, H J; Yang, M; Yeh, S C; Zalite, A; Zalite, Yu; Zhang, Z P; Zhao, J; Zhu, G Y; Zhu, R Y; Zhuang, H L; Zichichi, A; Zimmermann, B; Zöller, M

    2002-01-01

    Single top production in e^+e^- annihilations is searched for in data collected by the L3 detector at centre-of-mass energies from 189 to 209 GeV, corresponding to a total integrated luminosity of 634 pb-1. Investigating hadronic and semileptonic top decays, no evidence of single top production at LEP is obtained and upper limits on the single top cross section as a function of the centre-of-mass energy are derived. Limits on possible anomalous couplings, as well as on the scale of contact interactions responsible for single top production are determined.

  8. Nano-manipulation of single DNA molecules

    Hu Jun; Shanghai Jiaotong Univ., Shanghai; Lv Junhong; Wang Guohua; Wang Ying; Li Minqian; Zhang Yi; Li Bin; Li Haikuo; An Hongjie

    2004-01-01

    Nano-manipulation of single atoms and molecules is a critical technique in nanoscience and nanotechnology. This review paper will focus on the recent development of the manipulation of single DNA molecules based on atomic force microscopy (AFM). Precise manipulation has been realized including varied manipulating modes such as 'cutting', 'pushing', 'folding', 'kneading', 'picking up', 'dipping', etc. The cutting accuracy is dominated by the size of the AFM tip, which is usually 10 nm or less. Single DNA fragments can be cut and picked up and then amplified by single molecule PCR. Thus positioning isolation and sequencing can be performed. (authors)

  9. Single top quark production with CMS

    Piccolo Davide

    2013-11-01

    Full Text Available Measurements of single top quark production performed using the CMS experiment [1] data collected in 2011 at centre-of-mass energies of 7 TeV and in 2012 at 8 TeV, are presented. The cross sections for the electroweak production of single top quarks in the t-channel and in association with W-bosons is measured and the results are used to place constraints on the CKM matrix element Vtb. Measurements of top quark properties in single top quark production are also presented. The results include the measurement of the charge ratio in the single top t-channel.

  10. Sexual behavior of single adult American women.

    Duberstein Lindberg, Laura; Singh, Susheela

    2008-03-01

    Public policies promoting abstinence until marriage attempt to influence the sexual behavior of the more than 18 million American women who are currently single. An analysis of these women's behavior is needed to inform policies that are responsive to their sexual and reproductive health needs. Sexual behaviors, risk factors and reproductive health needs were examined among a nationally representative sample of 6,493 women aged 20-44 from the 2002 National Survey of Family Growth. Paired t tests were used to assess differences among single, married and cohabiting women by selected demographic, behavioral and risk measures. Thirty-six percent of women aged 20-44 are single, and nine in 10 single women are sexually experienced. Seventy percent of the latter women are currently sexually active; on average, they had intercourse in seven of the last 12 months. A higher proportion of single women (22%) than of cohabiting (9%) or married women (2%) have had two or more partners in the past year, and half of single women are at risk of unintended pregnancy. Furthermore, single women and cohabiting women are more likely to lack health insurance than are married women (21-25% vs. 12%). Because of the high level of sexual activity among single adult women, providers must address their reproductive health care needs and offer appropriate counseling and services. Government policies aimed at encouraging adult women to have sex only within marriage appear out of touch with the reality of the sexual behavior of single women.

  11. Single port VATS: recent developments in Asia.

    Yu, Peter S Y; Capili, Freddie; Ng, Calvin S H

    2016-03-01

    Single port video-assisted thoracic surgery (VATS) is the most recent evolution in minimally invasive thoracic surgery. With increasing global popularity, the single port VATS approach has been adopted by experienced thoracic surgeons in many Asian countries. From initial experience of single port VATS lobectomy to the more complex sleeve resection procedures now forming part of daily practice in some Asia institutes, the region has been the proving ground for single port VATS approaches' feasibility and safety. In addition, certain technical refinements in single port VATS lung resection and lymph node dissection have also sprung from Asia. Novel equipment designed to facilitate single port VATS allowing further reduce access trauma are being realized by the partnership between surgeons and the industries. Advanced thoracoscopes and staplers that are narrower and more maneuverable are particularly important in the smaller habitus of patients from Asia. These and similar new generation equipment are being applied to single port VATS in novel ways. As dedicated thoracic surgeons in the region continue to striving for excellence, innovative ideas in single incision access including subxiphoid and embryonic natural-orifice transluminal endoscopic surgery (e-NOTES) have been explored. Adjunct techniques and technology used in association with single port VATS such as non-intubated surgery, hybrid operating room image guidance and electromagnetic navigational bronchoscopy are all in rapid development in Asia.

  12. Self-Concept of Single Women.

    Gigy, Lynn L.

    1980-01-01

    Explores the self-concepts of single and married women. Single women had more psychiatric symptoms, valued personal growth and achievement, and were higher on assertion and poise. Married women were more likely to identify with kinship roles and household activities. (Author)

  13. Electrically Anisotropic Layered Perovskite Single Crystal

    Li, Ting-You

    2016-01-01

    -23). However, the difficulty in growing large-sized LOIHPs single crystal with superior electrical properties limits their practical applications. Here, we report a method to grow the centimeter-scaled LOIHP single crystal of [(HOC2H4NH3)2PbI4], demonstrating

  14. Confinement stabilises single crystal vaterite rods.

    Schenk, AS; Albarracin, EJ; Kim, YY; Ihli, J; Meldrum, FC

    2014-01-01

    Single-crystals of vaterite, the least-stable anhydrous polymorph of CaCO3, are rare in biogenic and synthetic systems. We here describe the synthesis of high aspect ratio single crystal vaterite rods under additive-free conditions by precipitating CaCO3 within the cylindrical pores of track-etch membranes.

  15. Single-Level and Multilevel Mediation Analysis

    Tofighi, Davood; Thoemmes, Felix

    2014-01-01

    Mediation analysis is a statistical approach used to examine how the effect of an independent variable on an outcome is transmitted through an intervening variable (mediator). In this article, we provide a gentle introduction to single-level and multilevel mediation analyses. Using single-level data, we demonstrate an application of structural…

  16. Reducing deaths in single vehicle collisions.

    Adminaite, D. Jost, G. Stipdonk, H. & Ward, H.

    2017-01-01

    A third of road deaths in the EU are caused by collisions that involve a single motorised vehicle where the driver, rider and/or passengers are killed but no other road users are involved. These single vehicle collisions (SVCs), and how to prevent them occurring, are the subject of this report.

  17. Single Mother Parenting and Adolescent Psychopathology.

    Daryanani, Issar; Hamilton, Jessica L; Abramson, Lyn Y; Alloy, Lauren B

    2016-10-01

    Children raised in single-mother families are at increased risk for psychopathology, but the mechanisms that help explain this relationship are understudied. In a community sample of diverse adolescents (N = 385, 52 % female, 48 % Caucasian) and their mothers, we hypothesized that single mothers would be more likely than cohabitating mothers to engage in negative parenting behaviors, which would predict adolescent psychopathology prospectively. Single mothers were more likely to engage in psychologically controlling behaviors, which predicted to their adolescent offspring experiencing higher rates of depressive symptoms and externalizing disorders. Girls were more susceptible to depressive symptoms via psychologically controlling parenting than boys in single-mother families. Further, single mothers were more likely to engage in rejecting parenting behaviors, which predicted to a higher prevalence of adolescent externalizing disorders. Surprisingly, rejection in single-mother families predicted to less severe anxiety symptoms in adolescents relative to two-parent families. It is likely that single mothers are not inherently inferior parents relative to cohabitating mothers; rather, their parenting practices are often compromised by a myriad of demands and stressors. Consistent with this postulate, low socioeconomic status was associated with single motherhood and negative parenting behaviors. Clinical implications and study limitations are discussed.

  18. BILATERAL SINGLE SESSION URETEROSCOPY FOR URETERAL ...

    Objectives: To determine the feasibility, safety and success rate of bilateral single session rigid retrograde ureteroscopy (URS) for bilateral ureteral calculi. Patients and Methods: Thirty-five patients underwent bilateral single session ureteroscopic calculus removal. Results: Out of 70 renal units in 35 patients treated, ...

  19. Experience with single-layer rectal anastomosis.

    Khubchandani, M; Upson, J

    1981-01-01

    Anastomotic dehiscence following resection of the large intestine is a serious complication. Satisfactory results of single-layer anastomosis depend upon meticulous technique and a scrupulously clean colon. Out of 65 single-layer anastomoses involving the rectum, significant leakage occurred in 4 patients. The results are reported in order to draw attention to the safety and efficacy of one-layer anastomosis.

  20. Saha equation, single and two particle states

    Kraeft, W.D.; Girardeau, M.D.; Strege, B.

    1990-01-01

    Single and two particle porperties in dense plasma are discussed in connection with their role in the mass action law for a partially ionized plasma. The two particle bound states are nearly density independent, while the continuum is essentially shifted. The single particle states are damped, and their energy has a negative shift and a parabolic behaviour for small momenta. (orig.)

  1. Single-Gender Education: Educators' Perspective

    Fry, John P.

    2009-01-01

    The examination of educator's views regarding single-gender education was the basis of this study. The significance of the intended study is to show the educator's view of single-gender education as it relates to student academic achievement and behavioral incidents. A quantitative study was conducted utilizing a sample population of regular and…

  2. Single port access for laparoscopic lateral segmentectomy.

    Inoue, Yoshihiro; Asakuma, Mitsuhiro; Hirokawa, Fumitoshi; Hayashi, Michihiro; Shimizu, Tetsunosuke; Uchiyama, Kazuhisa

    2017-12-01

    Single-port access laparoscopic lateral segmentectomy (LLS) has been developed as a novel minimally invasive surgery. We have experience with this LLS technique. To report our technique and patients' postoperative course in a series of single-port access LLS performed in our department. We also examine the cosmetic outcome, safety, and utility of the procedure. Between February 2010 and October 2016, 54 patients who underwent single- or multiple-port laparoscopic or open lateral segmentectomy (LS) were retrospectively analyzed with respect to cosmetic outcome, safety, and utility. In the single LLS group, the laparoscopic procedure was successfully completed for all 14 patients. The median operative time was significantly shorter in the single LLS group (123 min; range: 50-270 min) than in the other groups. Estimated blood loss was also significantly lower in the single LLS group (10 ml; range: 0-330 ml). During the first 7 postoperative days, the visual analog scale pain score and the use of additional analgesia were not significantly different between groups. The single LLS group had a 7.1% complication rate (Clavien-Dindo classification > IIIA); this was not significantly different between groups. Single-port access LLS is a procedure with excellent cosmetic results, although, with regard to invasiveness, there are no major differences from conventional LLS.

  3. A practical alternative to single tree selection?

    Gary W. Miller; H. Clay Smith

    1993-01-01

    When landowners want to develop and maintain an uneven-aged tree structure in eastern hardwood stands, single-tree selection often is suggested as the only advisable, long-term partial regeneration harvest method. Single-tree selection is preferred because it provides a means for improving quality and controlling stocking of the residual stand necessary for sustained...

  4. Single Finds. The case of Roman Egypt

    Christiansen, Erik

    2006-01-01

    Survery of single or stray finds from Roman Egypt and discussion of them as evidence for the circulation and use of coins......Survery of single or stray finds from Roman Egypt and discussion of them as evidence for the circulation and use of coins...

  5. Coupling single emitters to quantum plasmonic circuits

    Huck, Alexander; Andersen, Ulrik Lund

    2016-01-01

    In recent years, the controlled coupling of single-photon emitters to propagating surface plasmons has been intensely studied, which is fueled by the prospect of a giant photonic nonlinearity on a nanoscaled platform. In this article, we will review the recent progress on coupling single emitters...

  6. Retrofitting Domestic Hot Water Heaters for Solar Water Heating Systems in Single-Family Houses in a Cold Climate: A Theoretical Analysis

    Björn Karlsson

    2012-10-01

    Full Text Available One of the biggest obstacles to economic profitability of solar water heating systems is the investment cost. Retrofitting existing domestic hot water heaters when a new solar hot water system is installed can reduce both the installation and material costs. In this study, retrofitting existing water heaters for solar water heating systems in Swedish single-family houses was theoretically investigated using the TRNSYS software. Four simulation models using forced circulation flow with different system configurations and control strategies were simulated and analysed in the study. A comparison with a standard solar thermal system was also presented based on the annual solar fraction. The simulation results indicate that the retrofitting configuration achieving the highest annual performance consists of a system where the existing tank is used as storage for the solar heat and a smaller tank with a heater is added in series to make sure that the required outlet temperature can be met. An external heat exchanger is used between the collector circuit and the existing tank. For this retrofitted system an annual solar fraction of 50.5% was achieved. A conventional solar thermal system using a standard solar tank achieves a comparable performance for the same total storage volume, collector area and reference conditions.

  7. Extracting Models in Single Molecule Experiments

    Presse, Steve

    2013-03-01

    Single molecule experiments can now monitor the journey of a protein from its assembly near a ribosome to its proteolytic demise. Ideally all single molecule data should be self-explanatory. However data originating from single molecule experiments is particularly challenging to interpret on account of fluctuations and noise at such small scales. Realistically, basic understanding comes from models carefully extracted from the noisy data. Statistical mechanics, and maximum entropy in particular, provide a powerful framework for accomplishing this task in a principled fashion. Here I will discuss our work in extracting conformational memory from single molecule force spectroscopy experiments on large biomolecules. One clear advantage of this method is that we let the data tend towards the correct model, we do not fit the data. I will show that the dynamical model of the single molecule dynamics which emerges from this analysis is often more textured and complex than could otherwise come from fitting the data to a pre-conceived model.

  8. Single-incision total laparoscopic hysterectomy

    Sinha Rakesh

    2011-01-01

    Full Text Available Single-incision laparoscopic surgery is an alternative to conventional multiport laparoscopy. Single-access laparoscopy using a transumbilical port affords maximum cosmetic benefits because the surgical incision is hidden in the umbilicus. The advantages of single-access laparoscopic surgery may include less bleeding, infection, and hernia formation and better cosmetic outcome and less pain. The disadvantages and limitations include longer surgery time, difficulty in learning the technique, and the need for specialized instruments. Ongoing refinement of the surgical technique and instrumentation is likely to expand its role in gynecologic surgery in the future. We perform single-incision total laparoscopic hysterectomy using three ports in the single transumbilical incision.

  9. Single-event effect ground test issues

    Koga, R.

    1996-01-01

    Ground-based single event effect (SEE) testing of microcircuits permits characterization of device susceptibility to various radiation induced disturbances, including: (1) single event upset (SEU) and single event latchup (SEL) in digital microcircuits; (2) single event gate rupture (SEGR), and single event burnout (SEB) in power transistors; and (3) bit errors in photonic devices. These characterizations can then be used to generate predictions of device performance in the space radiation environment. This paper provides a general overview of ground-based SEE testing and examines in critical depth several underlying conceptual constructs relevant to the conduct of such tests and to the proper interpretation of results. These more traditional issues are contrasted with emerging concerns related to the testing of modern, advanced microcircuits

  10. Taking a lot of Pictures of Real Things and Making them into a Single Picture you can Move on a Computer

    Linneman, C.; Hults, C.

    2017-12-01

    This summer I spent my time in the largest state of all the states, with the people who take care of the most important parks, owned by all of us. My job was to take a lot of pictures of real things, small and large, and to make them into one piece on a computer, into pictures that can be moved and turned and can be easily shared across the world at any time. My job had three different classes: very small, pretty big, and very big. For the small things: Using a table that turns, I took many still pictures of old animals turned into rocks as well as things thrown away by people who are now dead. The pieces of rock and old things are important and exciting, but they can break quite easily, so only a few people are allowed to touch them. With the pictures you can move, many more people can learn about, "touch", and see them, but they use a computer instead of their hands. For a pretty big block of ice moving down a long area of land, I took many pictures of the end of it, while at the same time knowing just where I was on the face of the world. Using a computer, I again put all the pictures together into one picture that could be turned and moved. One person with a computer could look at any part of the piece of ice without having to actually visit it. Finally, for the very big things, I was part of a team that would fly slowly over the areas we were interested in, taking pictures about every half of a second. After taking tens of hundreds of pictures, the computer join all the pictures together into a single picture that showed each and every little up and down of the land that we had flown over, getting very few wrong. This way of making pictures you can move doesn't take as much money as other means, and it can be used on things of very different areas, from something as small as a finger to something as large as a huge field of ice moving slowly over time. The people who care for the parks that we all own don't have as much money as some, and in the biggest state

  11. Coherent single-photon absorption by single emitters coupled to 1D nanophotonic waveguides

    Chen, Yuntian; Wubs, Martijn; Mørk, Jesper

    2012-01-01

    We have derived an efficient model that allows calculating the dynamical single-photon absorption of an emitter coupled to a waveguide. We suggest a novel and simple structure that leads to strong single-photon absorption.......We have derived an efficient model that allows calculating the dynamical single-photon absorption of an emitter coupled to a waveguide. We suggest a novel and simple structure that leads to strong single-photon absorption....

  12. A Single Father's Shopping Bag: Purchasing Decisions in Single-Father Families

    Ziol-Guest, Kathleen M.

    2009-01-01

    Using data from the 1980 to 2003 panels of the Consumer Expenditure Survey, this article examines purchasing decisions in father-headed single-parent families. Single-father expenditures are compared to both married-parent expenditures and single-mother expenditures on 17 broad categories of household-level goods and services. Multivariate…

  13. Single-molecule dynamics in nanofabricated traps

    Cohen, Adam

    2009-03-01

    The Anti-Brownian Electrokinetic trap (ABEL trap) provides a means to immobilize a single fluorescent molecule in solution, without surface attachment chemistry. The ABEL trap works by tracking the Brownian motion of a single molecule, and applying feedback electric fields to induce an electrokinetic motion that approximately cancels the Brownian motion. We present a new design for the ABEL trap that allows smaller molecules to be trapped and more information to be extracted from the dynamics of a single molecule than was previously possible. In particular, we present strategies for extracting dynamically fluctuating mobilities and diffusion coefficients, as a means to probe dynamic changes in molecular charge and shape. If one trapped molecule is good, many trapped molecules are better. An array of single molecules in solution, each immobilized without surface attachment chemistry, provides an ideal test-bed for single-molecule analyses of intramolecular dynamics and intermolecular interactions. We present a technology for creating such an array, using a fused silica plate with nanofabricated dimples and a removable cover for sealing single molecules within the dimples. With this device one can watch the shape fluctuations of single molecules of DNA or study cooperative interactions in weakly associating protein complexes.

  14. Relaxor-PT Single Crystal Piezoelectric Sensors

    Xiaoning Jiang

    2014-07-01

    Full Text Available Relaxor-PbTiO3 piezoelectric single crystals have been widely used in a broad range of electromechanical devices, including piezoelectric sensors, actuators, and transducers. This paper reviews the unique properties of these single crystals for piezoelectric sensors. Design, fabrication and characterization of various relaxor-PT single crystal piezoelectric sensors and their applications are presented and compared with their piezoelectric ceramic counterparts. Newly applicable fields and future trends of relaxor-PT sensors are also suggested in this review paper.

  15. Single-cell technologies in environmental omics

    Kodzius, Rimantas; Gojobori, Takashi

    2015-01-01

    Environmental studies are primarily done by culturing isolated microorganisms or by amplifying and sequencing conserved genes. Difficulties understanding the complexity of large numbers of various microorganisms in an environment led to the development of techniques to enrich specific microorganisms for upstream analysis, ultimately leading to single-cell isolation and analyses. We discuss the significance of single-cell technologies in omics studies with focus on metagenomics and metatranscriptomics. We propose that by reducing sample heterogeneity using single-cell genomics, metaomic studies can be simplified.

  16. Single-cell technologies in environmental omics

    Kodzius, Rimantas

    2015-10-22

    Environmental studies are primarily done by culturing isolated microorganisms or by amplifying and sequencing conserved genes. Difficulties understanding the complexity of large numbers of various microorganisms in an environment led to the development of techniques to enrich specific microorganisms for upstream analysis, ultimately leading to single-cell isolation and analyses. We discuss the significance of single-cell technologies in omics studies with focus on metagenomics and metatranscriptomics. We propose that by reducing sample heterogeneity using single-cell genomics, metaomic studies can be simplified.

  17. CP Violation in Single Top Quark Production

    Geng, Weigang [Michigan State Univ., East Lansing, MI (United States)

    2012-01-01

    We present a search for CP violation in single top quark production with the DØ experiment at the Tevatron proton-antiproton collider. CP violation in the top electroweak interaction results in different single top quark production cross sections for top and antitop quarks. We perform the search in the single top quark final state using 5.4 fb-1 of data, in the s-channel, t-channel, and for both combined. At this time, we do not see an observable CP asymmetry.

  18. Single-instruction multiple-data execution

    Hughes, Christopher J

    2015-01-01

    Having hit power limitations to even more aggressive out-of-order execution in processor cores, many architects in the past decade have turned to single-instruction-multiple-data (SIMD) execution to increase single-threaded performance. SIMD execution, or having a single instruction drive execution of an identical operation on multiple data items, was already well established as a technique to efficiently exploit data parallelism. Furthermore, support for it was already included in many commodity processors. However, in the past decade, SIMD execution has seen a dramatic increase in the set of

  19. Thermally activated, single component epoxy systems

    Unruh, David A.

    2011-08-23

    A single component epoxy system in which the resin and hardener components found in many two-component epoxies are combined onto the same molecule is described. The single molecule precursor to the epoxy resin contains both multiple epoxide moieties and a diamine held latent by thermally degradable carbamate linkages. These bis-carbamate "single molecule epoxies" have an essentially infinite shelf life and access a significant range in curing temperatures related to the structure of the carbamate linkages used. © 2011 American Chemical Society.

  20. Thermally activated, single component epoxy systems

    Unruh, David A.; Pastine, Stefan J.; Moreton, Jessica C.; Frechet, Jean

    2011-01-01

    A single component epoxy system in which the resin and hardener components found in many two-component epoxies are combined onto the same molecule is described. The single molecule precursor to the epoxy resin contains both multiple epoxide moieties and a diamine held latent by thermally degradable carbamate linkages. These bis-carbamate "single molecule epoxies" have an essentially infinite shelf life and access a significant range in curing temperatures related to the structure of the carbamate linkages used. © 2011 American Chemical Society.

  1. Single spin asymmetry for charm mesons

    Dominguez Zacarias, G. [PIMAyC, Eje Central Lazaro Cardenas No. 152, Apdo. Postal 14-805, D.F. (Mexico); Herrera, G.; Mercado, J. [Centro de Investigacion y de Estudios Avanzados, Apdo. Postal 14-740, D.F. (Mexico)

    2007-08-15

    We study single spin asymmetries of D{sup 0} and D{sup -} mesons in polarized proton-proton collisions. A two component model is used to describe charm meson production. The production of D mesons occurs by recombination of the constituents present in the initial state as well as by fragmentation of quarks in the final state. This model has proved to describe the production of charm. The recombination component involves a mechanism of spin alignment that ends up in a single spin asymmetry. Experimental measurements of single spin asymmetry for pions at RHIC are compared with the model. Predictions for the asymmetry in D mesons are presented. (orig.)

  2. Single spin asymmetry for charm mesons

    Dominguez Zacarias, G.; Herrera, G.; Mercado, J.

    2007-01-01

    We study single spin asymmetries of D 0 and D - mesons in polarized proton-proton collisions. A two component model is used to describe charm meson production. The production of D mesons occurs by recombination of the constituents present in the initial state as well as by fragmentation of quarks in the final state. This model has proved to describe the production of charm. The recombination component involves a mechanism of spin alignment that ends up in a single spin asymmetry. Experimental measurements of single spin asymmetry for pions at RHIC are compared with the model. Predictions for the asymmetry in D mesons are presented. (orig.)

  3. Automated Single Cell Data Decontamination Pipeline

    Tennessen, Kristin [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; Pati, Amrita [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.

    2014-03-21

    Recent technological advancements in single-cell genomics have encouraged the classification and functional assessment of microorganisms from a wide span of the biospheres phylogeny.1,2 Environmental processes of interest to the DOE, such as bioremediation and carbon cycling, can be elucidated through the genomic lens of these unculturable microbes. However, contamination can occur at various stages of the single-cell sequencing process. Contaminated data can lead to wasted time and effort on meaningless analyses, inaccurate or erroneous conclusions, and pollution of public databases. A fully automated decontamination tool is necessary to prevent these instances and increase the throughput of the single-cell sequencing process

  4. Approaches to single-nanoparticle catalysis.

    Sambur, Justin B; Chen, Peng

    2014-01-01

    Nanoparticles are among the most important industrial catalysts, with applications ranging from chemical manufacturing to energy conversion and storage. Heterogeneity is a general feature among these nanoparticles, with their individual differences in size, shape, and surface sites leading to variable, particle-specific catalytic activity. Assessing the activity of individual nanoparticles, preferably with subparticle resolution, is thus desired and vital to the development of efficient catalysts. It is challenging to measure the activity of single-nanoparticle catalysts, however. Several experimental approaches have been developed to monitor catalysis on single nanoparticles, including electrochemical methods, single-molecule fluorescence microscopy, surface plasmon resonance spectroscopy, X-ray microscopy, and surface-enhanced Raman spectroscopy. This review focuses on these experimental approaches, the associated methods and strategies, and selected applications in studying single-nanoparticle catalysis with chemical selectivity, sensitivity, or subparticle spatial resolution.

  5. Single DNA denaturation and bubble dynamics

    Metzler, Ralf; Ambjoernsson, Tobias; Hanke, Andreas; Fogedby, Hans C

    2009-01-01

    While the Watson-Crick double-strand is the thermodynamically stable state of DNA in a wide range of temperature and salt conditions, even at physiological conditions local denaturation bubbles may open up spontaneously due to thermal activation. By raising the ambient temperature, titration, or by external forces in single molecule setups bubbles proliferate until full denaturation of the DNA occurs. Based on the Poland-Scheraga model we investigate both the equilibrium transition of DNA denaturation and the dynamics of the denaturation bubbles with respect to recent single DNA chain experiments for situations below, at, and above the denaturation transition. We also propose a new single molecule setup based on DNA constructs with two bubble zones to measure the bubble coalescence and extract the physical parameters relevant to DNA breathing. Finally we consider the interplay between denaturation bubbles and selectively single-stranded DNA binding proteins.

  6. Single Shell Tank (SST) Program Plan

    HAASS, C.C.

    2000-01-01

    This document provides an initial program plan for retrieval of the single-shell tank waste. Requirements, technical approach, schedule, organization, management, and cost and funding are discussed. The program plan will be refined and updated in fiscal year 2000

  7. Single Incision Laparoscopic Splenectomy: Our First Experiences

    Umut Barbaros

    2011-06-01

    Full Text Available Objective: Most laparoscopic surgeons have attempted to reduce incisional morbidity and improve cosmetic outcomes by using less and smaller trocars. Single incision laparoscopic splenectomy is a new laparoscopic procedure. Herein we would like to present our experiences.Material and Methods: Between January 2009 and June 2009, data of the 7 patients who underwent single incision laparoscopic splenectomy were evaluated retrospectively.Results: There were 7 patients (5 females and 2 males with a mean age of 29.9 years. The most common splenectomy indication was idiopathic thrombocytopenic purpura. Single incision laparoscopic splenectomy was performed successfully in 6 patients. In one patient the operation was converted to an open procedure.Conclusion: With surgeons experienced in minimally invasive surgery, single incision laparoscopic splenectomy could be performed successfully. However, in order to demonstrate the differneces between standard laparoscopic splenectomy and SILS splenetomy, prospective randomized comparative studies are required.

  8. Single isospin decay amplitude and CP violation

    Deshpande, N.G. [Oregon Univ., Eugene, OR (United States). Inst. of Theoretical Science; He, Xiaogang [Melbourne Univ., Parkville, VIC (Australia). School of Physics; Pakvasa, S. [Hawaii Univ., Honolulu, HI (United States). Dept. of Physics and Astronomy

    1996-06-01

    While for K meson or hyperon decays, the partial rate asymmetries are always zero if the final states are single isospin states, in B decays the situation is dramatically different and partial rate asymmetries can be non-zero if the final states are single isospin states. Partial rate asymmetries were calculated for several B decays with single isospin amplitude in the finale states using factorization approximation. It was found that more intermediate on-shell states with different Cabbibbo-Kobayashi-Maskawa factors are allowed in B decay and CP violating partial rate asymmetries need not to be zero even if the final state contains only a single isospin state. 17 refs., 4 figs.

  9. A Variable Single Photon Plasmonic Beamsplitter

    Israelsen, Niels Møller; Kumar, Shailesh; Huck, Alexander

    Plasmonic structures can both be exploited for scaling down optical components beyond the diffraction limit and enhancing andcollecting the emission from a single dipole emitter. Here, we experimentally demonstrate adiabatic coupling between two silvernanowires using a nitrogen vacancy center as ...

  10. Defect free single crystal thin layer

    Elafandy, Rami Tarek Mahmoud

    2016-01-28

    A gallium nitride film can be a dislocation free single crystal, which can be prepared by irradiating a surface of a substrate and contacting the surface with an etching solution that can selectively etch at dislocations.

  11. Who will resettle single Syrian men?

    Lewis Turner

    2017-02-01

    Full Text Available Resettlement programmes for Syrian refugees severely restrict access to resettlement for single Syrian men, despite the conditions of vulnerability, insecurity and danger in which they live.

  12. Nanospintronics: when spintronics meets single electron physics

    Seneor, Pierre; Bernand-Mantel, Anne; Petroff, Frederic

    2007-01-01

    As spintronics goes nano, new phenomena are predicted resulting from the interplay between spin dependent transport and single electron physics. The long term goal of manipulating spins one by one would open a promising path to quantum computing. Towards this end, there is an ever-growing effort to connect spin tanks (i.e. ferromagnetic leads) to smaller and smaller objects in order to study spintronics in reduced dimensions. As the dimensions are reduced, spin dependent transport is predicted to interplay with quantum and/or single electron charging effects. We review experiments and theories on the interplay between Coulomb blockade and spin properties (namely magneto-Coulomb effects) in structures where a single nano-object is connected to ferromagnetic leads. We then discuss briefly future directions in the emerging field of nanospintronics towards quantum dots, carbon nanotubes and single molecule magnets

  13. Electric field imaging of single atoms

    Shibata, Naoya; Seki, Takehito; Sánchez-Santolino, Gabriel; Findlay, Scott D.; Kohno, Yuji; Matsumoto, Takao; Ishikawa, Ryo; Ikuhara, Yuichi

    2017-01-01

    In scanning transmission electron microscopy (STEM), single atoms can be imaged by detecting electrons scattered through high angles using post-specimen, annular-type detectors. Recently, it has been shown that the atomic-scale electric field of both the positive atomic nuclei and the surrounding negative electrons within crystalline materials can be probed by atomic-resolution differential phase contrast STEM. Here we demonstrate the real-space imaging of the (projected) atomic electric field distribution inside single Au atoms, using sub-Å spatial resolution STEM combined with a high-speed segmented detector. We directly visualize that the electric field distribution (blurred by the sub-Å size electron probe) drastically changes within the single Au atom in a shape that relates to the spatial variation of total charge density within the atom. Atomic-resolution electric field mapping with single-atom sensitivity enables us to examine their detailed internal and boundary structures. PMID:28555629

  14. Single bunched beam generation without subharmonic prebuncher

    Kobayashi, T.; Tagawa, S.

    1995-01-01

    The intensity of the accelerated single bunched electron beam depends on the performance of the electron gun and the fast cathode pulser. The electron beam is emitted by a Y-796 cathode assembly with a cathode of 2 cm 2 (8 A/cm 2 ), and an extracted voltage of 90 kV. The maximum charge of the single bunched beam was attained at 1.5 nC/pulse using SHB. Recently, a single bunched beam has been generated by an ultrafast cathode pulser (rise and fall time <100 ps pulse height -2 kV at 50 Ω) without SHB. The charge of the accelerated electron beam is about 40 pC/pulse (pulse width <10 ps) without the production of a satellite beam. This result show that a single bunched beam can be produced by the linear accelerator without SHB. ((orig.))

  15. Distributed Processing Using Single-chip Microcomputers

    Pritchett, William

    1996-01-01

    This project investigates the use of single-chip microprocessors as nodes in a token ring control network and explores the implementation of a protocol to manage communication across such a network...

  16. Single Family Loan Sale Initiative - National Offering

    Department of Housing and Urban Development — The FHA Office of Housing is conducting a series of mortgage loan sales under the Single Family Loan Sale (SFLS) Initiative. The current sales structure consists of...

  17. Single Shell Tank (SST) Program Plan

    HAASS, C.C.

    2000-03-21

    This document provides an initial program plan for retrieval of the single-shell tank waste. Requirements, technical approach, schedule, organization, management, and cost and funding are discussed. The program plan will be refined and updated in fiscal year 2000.

  18. Epigenetics reloaded: the single-cell revolution.

    Bheda, Poonam; Schneider, Robert

    2014-11-01

    Mechanistically, how epigenetic states are inherited through cellular divisions remains an important open question in the chromatin field and beyond. Defining the heritability of epigenetic states and the underlying chromatin-based mechanisms within a population of cells is complicated due to cell heterogeneity combined with varying levels of stability of these states; thus, efforts must be focused toward single-cell analyses. The approaches presented here constitute the forefront of epigenetics research at the single-cell level using classic and innovative methods to dissect epigenetics mechanisms from the limited material available in a single cell. This review further outlines exciting future avenues of research to address the significance of epigenetic heterogeneity and the contributions of microfluidics technologies to single-cell isolation and analysis. Copyright © 2014 Elsevier Ltd. All rights reserved.

  19. Demonstration of Coupled Tiamat Single Assembly Calculations

    Novascone, Stephen R. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Hales, Jason D. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Gardner, Russell [Idaho National Lab. (INL), Idaho Falls, ID (United States); Pawlowski, R. P. P. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Pastore, Giovanni [Idaho National Lab. (INL), Idaho Falls, ID (United States); Toth, Alex [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Clarno, Kevin T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Collins, Benjamin S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Stimpson, Shane G. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Powers, Jeffrey J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-06-01

    This report corresponds to milestone L3:PHI.PCI.P15.03, which was originally intended to investigate the time discretization approaches with the newly developed fully coupled Tiamat capability, targeting single assembly problems.

  20. Single-photon manipulation in Nanophotonic Circuits

    Hansen, Sofie Lindskov

    Quantum dots in photonic nanostructures has long been known to be a very powerful and versatile solid-state platform for conducting quantum optics experiments. The present PhD thesis describes experimental demonstrations of single-photon generation and subsequent manipulation all realized...... on a gallium arsenide platform. This platform offers near-unity coupling between embedded single-photon emitters and a photonic mode, as well as the ability to suppress decoherence mechanisms, making it highly suited for quantum information applications. In this thesis we show how a single-photon router can...... be realized on a chip with embedded quantum dots. This allows for on-chip generation and manipulation of single photons. The router consists of an on-chip interferometer where the phase difference between the arms of the interferometer is controlled electrically. The response time of the device...

  1. Defect free single crystal thin layer

    Elafandy, Rami Tarek Mahmoud; Ooi, Boon S.

    2016-01-01

    A gallium nitride film can be a dislocation free single crystal, which can be prepared by irradiating a surface of a substrate and contacting the surface with an etching solution that can selectively etch at dislocations.

  2. Barium Isotopes in Single Presolar Grains

    Pellin, M. J.; Davis, A. M.; Savina, M. R.; Kashiv, Y.; Clayton, R. N.; Lewis, R. S.; Amari, S.

    2001-01-01

    Barium isotopic compositions of single presolar grains were measured by laser ablation laser resonant ionization mass spectrometry and the implications of the data for stellar processes are discussed. Additional information is contained in the original extended abstract.

  3. A theoretical overview on single hard diffraction

    Wuesthoff, M.

    1996-01-01

    The concept of the Pomeron structure function and its application in Single Hard Diffraction at hadron colliders and in diffractive Deep Inelastic Scattering is critically reviewed. Some alternative approaches are briefly surveyed with a focus on QCD inspired models

  4. Single Top-Quark Production at CDF

    CERN. Geneva

    2008-01-01

    The main challenge of the single top-quark search at the Tevatron is the huge background from W+jets events and QCD events, which makes the use of advanced multivariate techniques essential. The recent single top analyses using either the matrix element method, neural networks, likelihood discriminants or boosted decision trees as well as the combination of the former three analyses will be presented...

  5. Bisimulation for Single-Agent Plausibility Models

    Andersen, Mikkel Birkegaard; Bolander, Thomas; van Ditmarsch, H.

    2013-01-01

    define a proper notion of bisimulation, and prove that bisimulation corresponds to logical equivalence on image-finite models. We relate our results to other epistemic notions, such as safe belief and degrees of belief. Our results imply that there are only finitely many non-bisimilar single......-agent epistemic plausibility models on a finite set of propositions. This gives decidability for single-agent epistemic plausibility planning....

  6. European Banking with a Single Currency

    Jean Dermine

    1996-01-01

    At the Madrid summit in December 1995, the EU heads of state or government endorsed a three-phase plan for the introduction of the single currency. The purpose of the paper is to identify how, besides an obvious fall in revenue from intra-European currencies trading, a single currency will alter fundamentally and permanently European banking markets. A common currency will likely change the sources of competitive advantage in various markets such as those of government bonds and their fast gr...

  7. Single particle dynamics in circular accelerators

    Ruth, R.D.

    1986-10-01

    The purpose of this paper is to introduce the reader to the theory associated with the transverse dynamics of single particle, in circular accelerators. The discussion begins with a review of Hamiltonian dynamics and canonical transformations. The case of a single particle in a circular accelerator is considered with a discussion of non-linear terms and chromaticity. The canonical perturbation theory is presented and nonlinear resonances are considered. Finally, the concept of renormalization and residue criterion are examined. (FI)

  8. From Single Microparticles to Microfluidic Emulsification

    Kinoshita, K.; Ortiz, Elisa Parra; Hussein, Abdirazak

    2016-01-01

    The micropipette manipulation technique is capable of making fundamental single particle measurements and analyses. This information is critical for establishing processing parameters in systems such as microfluidics and homogenization. To demonstrate what can be achieved at the single particle l...... a very useful tool for understanding microsphere-processes and hence can help to establish process conditions without resorting to expensive and material-consuming bulk particle runs....

  9. Preparation of TiC single crystals

    Scheerer, B.; Fink, J.; Reichardt, W.

    1975-07-01

    TiC single crystals were prepared by vertical zone melting for measurements of the phonon dispersion by inelastic neutron scattering. The influence of the starting material and of the growing conditions on the growth of the crystal were studied. The crystals were characterized by chemical methods, EMX and neutron diffraction. It was possible to grow single crystals with a volume of up to 0.6 cm 3 and mosaic spread of less then 0.4 0 . (orig.) [de

  10. Single sheet metal oxides and hydroxides

    Huang, Lizhi

    The synthesis of layered double hydroxides (LDHs) provides a relatively easy and traditional way to build versatile chemical compounds with a rough control of the bulk structure. The delamination of LDHs to form their single host layers (2D nanosheets) and the capability to reassemble them offer......) Delamination of the LDHs structure (oxGRC12) with the formation of single sheet iron (hydr)oxide (SSI). (3) Assembly of the new 2D nanosheets layer by layer to achieve desired functionalities....

  11. New Physics in Single-Top Production

    Kind, OM; The ATLAS collaboration

    2013-01-01

    In this presentation for TOP 2013 the latest results on searches of physics beyond the Standard Model using single-top signatures from CDF, CMS, D0 and ATLAS are collected. This includes searches for unknown resonances like W' or b*, measurements of the W helicity fractions and top polarisation in single-top events, as well as tests for CP violation, FCNC or anomalous weak couplings.

  12. Robotic single-site pelvic lymphadenectomy.

    Tateo, Saverio; Nozza, Arrigo; Del Pezzo, Chiara; Mereu, Liliana

    2014-09-01

    To examine the feasibility of performing pelvic lymphadenectomy with robotic single site approach. Recent papers described the feasibility of robotic-single site hysterectomy [1-3] for benign and malign pathologies but only with the development of new single site 5mm instruments as the bipolar forceps, robotic single site platform can be safely utilized also for lymphadenectomy. A 65 year-old, multiparous patient with a body mass index of 22.5 and diagnosed with well differentiated adenocarcinoma of the endometrium underwent a robotic single-site peritoneal washing, total hysterectomy, bilateral adnexectomy and pelvic lymphadenectomy. The procedure was performed using the da Vinci Si Surgical System (Intuitive Surgical, Sunnyvale, CA) through a single 2,5 cm umbilical incision, with a multi-channel system and two single site robotic 5mm instruments. A 3-dimensional, HD 8.5mm endoscope and a 5mm accessory instrument were also utilized. Type I lymphonodes dissection for external iliac and obturator regions was performed [4]. Total operative time was 210 min; incision, trocar placement and docking time occurring in 12 min. Total console time was 183 min, estimated blood loss was 50 ml, no intra-operative or post-operative complications occurred. Hospital discharge occurred on post operative day 2 and total number of lymphnodes removed was 33. Difficulties in term of instrument's clashing and awkward motions have been encountered. Robotic single-site pelvic lymphadenectomy using bipolar forceps and monopolar hook is feasible. New developments are needed to improve surgical ergonomics and additional studies should be performed to explore possible benefits of this procedure. Copyright © 2014 Elsevier Inc. All rights reserved.

  13. Electrically Anisotropic Layered Perovskite Single Crystal

    Li, Ting-You

    2016-04-01

    Organic-inorganic hybrid perovskites (OIHPs), which are promising materials for electronic and optoelectronic applications (1-10), have made into layered organic-inorganic hybrid perovskites (LOIHPs). These LOIHPs have been applied to thin-film transistors, solar cells and tunable wavelength phosphors (11-18). It is known that devices fabricated with single crystal exhibit the superior performance, which makes the growth of large-sized single crystals critical for future device applications (19-23). However, the difficulty in growing large-sized LOIHPs single crystal with superior electrical properties limits their practical applications. Here, we report a method to grow the centimeter-scaled LOIHP single crystal of [(HOC2H4NH3)2PbI4], demonstrating the potentials in mass production. After that, we reveal anisotropic electrical and optoelectronic properties which proved the carrier propagating along inorganic framework. The carrier mobility of in-inorganic-plane (in-plane) devices shows the average value of 45 cm2 V–1 s–1 which is about 100 times greater than the record of LOIHP devices (15), showing the importance of single crystal in device application. Moreover, the LOIHP single crystals show its ultra-short carrier lifetime of 42.7 ps and photoluminescence quantum efficiency (PLQE) of 25.4 %. We expect this report to be a start of LOIHPs for advanced applications in which the anisotropic properties are needed (24-25), and meets the demand of high-speed applications and fast-response applications.

  14. Structure of single-chain single crystals of isotactic polystyrene and their radiation resistance

    Bu Haishan; Cao Jie; Xu Shengyong; Zhang Ze

    1997-01-01

    The structure of the single-chain single crystals of isotactic polystyrene (i-PS) was investigated by electron diffraction (ED) and high resolution electron microscopy (HREM). The nano-scale single-chain single crystals were found to be very stable to electron irradiation. According to the unit cell of i-PS crystals, the reflection rings in ED pattern and the lattice fringes in HREM images could be indexed, but the lower-index diffractions were not found. It is proposed that the single-chain single crystals are very small, thus secondary electrons may be allowed to escape and radiation damage is highly reduced, and that there are less lower-index lattice planes in the single-chain single crystals to provide sufficient diffraction intensity for recording. HREM images can be achieved at room temperature in the case of single-chain single crystals because of its stability to electron irradiation, therefore, this might be a novel experimental approach to the study of crystal structure of macromolecules

  15. Work life and mental wellbeing of single and non-single working mothers in Scandinavia.

    Bull, Torill; Mittelmark, Maurice B

    2009-08-01

    This study examined levels and predictors of mental wellbeing in Scandinavian working single and non-single mothers, with a special focus on financial stress, job characteristics and work-family conflict. The European Social Survey Round 2 (2005) provided questionnaire data from 73 single and 432 non-single working mothers in Denmark, Sweden and Norway. Respondents answered questions about the outcome variables life satisfaction, happiness, and positive affect, and predictor variables financial stress, job characteristics, work-family conflict, and social support. Hierarchical multiple regression was used to assess the relationships between predictor variables and mental wellbeing outcomes. Single working mothers scored significantly lower on life satisfaction and happiness, but not on positive affect, than did non-single mothers. Financial stress was higher in the single mother group. There were no significant differences in levels of enriching or stressful job characteristics, or in levels of social support. While financial stress and work-family conflict were important predictors in both groups, the relationship between financial stress and wellbeing was far stronger in the single mother group. Confidant support was a significant predictor only in the single mother group, and social participation only in the non-single mothers group. This study suggests that the Scandinavian welfare democracies have not yet been successful in relieving the financial pressure experienced by single working mothers. Development of efficient financial support systems should be prioritized. Ways to reduce work-family conflict in both single and non-single mothers in Scandinavia should also be given increased attention.

  16. Chemistry and Students with Blindness: The Hurdles Are Not What You Think

    Lewis, Amy L. Micklos

    2012-01-01

    Statistics have shown that individuals with disabilities are underrepresented in the science, technology, engineering, and mathematics (STEM) fields. This work focused on exploring how three students with blindness enrolled in a full-inclusion high-school chemistry class experienced and conceptualized content in order to inform educators,…

  17. Bacteriocins of food grade lactic acid bacteria in hurdle technology for milk and dairy

    The use of high temperature/short time (HTST) pasteurization has proven effective in eliminating microbial contaminants from raw milk; however some thermoduric bacteria and spore-formers have been reported to survive pasteurization at low numbers. Furthermore, improper pasteurization, post-pasteuri...

  18. Getting nano tattoos right - a checklist of legal and ethical hurdles for an emerging nanomedical technology.

    Bennett, Michael G; Naranja, R John

    2013-08-01

    The nano tattoo represents a nascent technology designed to be implanted in the skin to provide continuous and reliable glucose detection for diabetics. Its potential benefits are compelling not only for its ability to prevent diabetic complications and decrease related social costs, but also for its ease of use and relative patient-user comfort. This Note aims to articulate a checklist of fundamental intellectual property, bioethical and system design issues that are appropriately considered in the pre-clinical, pre-commercialization phase of nano tattoo development. Early and regular consideration of these factors can increase the odds of a societally beneficial dissemination of this device by engaging relevant researcher, medical, patient-user and patient-advocate communities concerned with its appropriate application, as well as policymaking communities focused on effectively managing diabetes-related healthcare costs. The checklist of factors includes fundamental issues and is generally applicable to nanomedical inventions. This paper presents a comprehensive list of fundamental intellectual property, bioethical, and system design issues to be considered in the pre-commercialization phase of nanomedicine development, through the specific example of nano tattoo development. Nano tattoo is designed to be implanted in the skin to provide reliable glucose monitoring for diabetics, enabling enhanced prevention of complications and decreased socioeconomic costs. Copyright © 2013 Elsevier Inc. All rights reserved.

  19. Bringing plant-based veterinary vaccines to market: Managing regulatory and commercial hurdles.

    MacDonald, Jacqueline; Doshi, Ketan; Dussault, Marike; Hall, J Christopher; Holbrook, Larry; Jones, Ginny; Kaldis, Angelo; Klima, Cassidy L; Macdonald, Phil; McAllister, Tim; McLean, Michael D; Potter, Andrew; Richman, Alex; Shearer, Heather; Yarosh, Oksana; Yoo, Han Sang; Topp, Edward; Menassa, Rima

    2015-12-01

    The production of recombinant vaccines in plants may help to reduce the burden of veterinary diseases, which cause major economic losses and in some cases can affect human health. While there is abundant research in this area, a knowledge gap exists between the ability to create and evaluate plant-based products in the laboratory, and the ability to take these products on a path to commercialization. The current report, arising from a workshop sponsored by an Organisation for Economic Co-operation and Development (OECD) Co-operative Research Programme, addresses this gap by providing guidance in planning for the commercialization of plant-made vaccines for animal use. It includes relevant information on developing business plans, assessing market opportunities, manufacturing scale-up, financing, protecting and using intellectual property, and regulatory approval with a focus on Canadian regulations. Crown Copyright © 2015. Published by Elsevier Inc. All rights reserved.

  20. Collective bargaining: An analysis of hurdles and applicability in the public sector

    Daniel Chigudu

    2015-04-01

    Full Text Available This article discusses the arguments against adopting collective bargaining in the public sector and its benefits. Collective bargaining in the public sector is viewed primarily as undermining democratic governance in one way and paradoxically it is seen as an essential part of democratic governance. In the former view, collective bargaining in the public sector is seen as an interference with administrative law for personal benefit to the detriment of the taxpayer. Proponents of this view argue that unionising public sector employees encourages disloyalty to the government at the expense of public welfare. In the later view, public sector collective bargaining is viewed as a fundamental human right in a pluralistic society. Advocates of this view posit that, public sector unions provide a collective voice that stimulates improvement of government services as well as sound administration of law. They also argue that, public sector collective bargaining represents public policy interests and serves as a watchdog to government’s monopoly power in employment matters. Public sector unions raise employee salaries and perks to levels higher than they would have been in the absence of collective bargaining. These two opposite views are subjected to a critical analysis in this paper, with empirical evidence for both the benefits of public sector collective bargaining and arguments against public sector unions. The article found that public sector collective bargaining depends on the socio-economic background of states although international laws favour public sector unionism.

  1. Two-stage hepatectomy: who will not jump over the second hurdle?

    Turrini, O; Ewald, J; Viret, F; Sarran, A; Goncalves, A; Delpero, J-R

    2012-03-01

    Two-stage hepatectomy uses compensatory liver regeneration after a first noncurative hepatectomy to enable a second curative resection in patients with bilobar colorectal liver metastasis (CLM). To determine the predictive factors of failure of two-stage hepatectomy. Between 2000 and 2010, 48 patients with irresectable CLM were eligible for two-stage hepatectomy. The planned strategy was a) cleaning of the left hepatic lobe (first hepatectomy), b) right portal vein embolisation and c) right hepatectomy (second hepatectomy). Six patients had occult CLM (n = 5) or extra-hepatic disease (n = 1), which was discovered during the first hepatectomy. Thus, 42 patients completed the first hepatectomy and underwent portal vein embolisation in order to receive the second hepatectomy. Eight patients did not undergo a second hepatectomy due to disease progression. Upon univariate analysis, two factors were identified that precluded patients from having the second hepatectomy: the combined resection of a primary tumour during the first hepatectomy (p = 0.01) and administration of chemotherapy between the two hepatectomies (p = 0.03). An independent association with impairment to perform the two-stage strategy was demonstrated by multivariate analysis for only the combined resection of the primary colorectal cancer during the first hepatectomy (p = 0.04). Due to the small number of patients and the absence of equivalent conclusions in other studies, we cannot recommend performance of an isolated colorectal resection prior to chemotherapy. However, resection of an asymptomatic primary tumour before chemotherapy should not be considered as an outdated procedure. Copyright © 2011 Elsevier Ltd. All rights reserved.

  2. The use of cryogenic helium for classical turbulence: Promises and hurdles

    Niemela, J.J.; Sreenivasan, K.R.

    2006-12-01

    Fluid turbulence is a paradigm for non-linear systems with many degrees of freedom and important in numerous applications. Because the analytical understanding of the equations of motion is poor, experiments and, lately, direct numerical simulations of the equations of motion, have been fundamental to making progress. In this vein, a concerted experimental effort has been made to take advantage of the unique properties of liquid and gaseous helium at low temperatures near or below the critical point. We discuss the promise and impact of results from recent helium experiments and identify the current technical barriers which can perhaps be removed by low temperature researchers. We focus mainly on classical flows that utilize helium above the lambda line, but touch on those aspects below that exhibit quasi-classical behavior. (author)

  3. Modeling Caries Experience : Advantages of the Use of the Hurdle Model

    Hofstetter, Hedwig; Dusseldorp, Elise; Zeileis, Achim; Schuller, Annemarie A.

    2016-01-01

    In dental epidemiology, the decayed (D), missing (M), and filled (F) teeth or surfaces index (DFM index) is a frequently used measure. The DMF index is characterized by a strongly positive skewed distribution with a large stack of zero counts for those individuals without caries experience.

  4. Modeling Caries Experience: Advantages of the Use of the Hurdle Model

    Hofstetter, H.; Dusseldorp, E.; Zeileis, A.; Schuller, A.A.

    2016-01-01

    In dental epidemiology, the decayed (D), missing (M), and filled (F) teeth or surfaces index (DFM index) is a frequently used measure. The DMF index is characterized by a strongly positive skewed distribution with a large stack of zero counts for those individuals without caries experience.

  5. Ego Is a Hurdle in Second Language Learning: A Contrastive Study between Adults and Children

    Abdullah, Shumaila; Akhter, Javed

    2015-01-01

    The aim of this research paper is to find out by comparing and contrasting between the adults and children in second language learning process how language ego of adult learners affects them to learn second language, and how it becomes a barrier for them in second language learning process. Nowadays learning English as foreign and second language…

  6. Exploring hurdles to transfer : student experiences of applying knowledge across disciplines

    Lappalainen, Jouni; Rosqvist, Juho

    2015-04-01

    This paper explores the ways students perceive the transfer of learned knowledge to new situations - often a surprisingly difficult prospect. The novel aspect compared to the traditional transfer studies is that the learning phase is not a part of the experiment itself. The intention was only to activate acquired knowledge relevant to the transfer target using a short primer immediately prior to the situation where the knowledge was to be applied. Eight volunteer students from either mathematics or computer science curricula were given a task of designing an adder circuit using logic gates: a new context in which to apply knowledge of binary arithmetic and Boolean algebra. The results of a phenomenographic classification of the views presented by the students in their post-experiment interviews are reported. The degree to which the students were conscious of the acquired knowledge they employed and how they applied it in a new context emerged as the differentiating factors.

  7. Ensuring microbiological safety and extending the shelf life of shelled sweet corn kernels using hurdle technology

    Kumar, Sanjeev; Gautam, Satyendra

    2015-01-01

    Shelled sweet corn kernels are prone to microbial contaminations due to high moisture and nutrient contents. Post harvest handling further aggravates the condition and makes the product highly perishable and unsafe. In freshly shelled kernels total aerobic plate count, yeast mold count and presumptive coliforms were found to be ∼ 8, 7, and 4 log cfu/g, respectively. IMViC analysis confirmed presence of opportunistic pathogens like Escherichia coli and Enterobacteraerogenes in these samples. Besides, occurrence of mycotoxin such as ochratoxin A (OTA), classified as a possible carcinogenic compound, was found to be high in sweet corn samples spiked with toxigenic strain. To address this issue, a combination process including NaOCl washing (200 ppm for 5 min), hot water blanching (60℃ for 5 min), air drying, LDPE packaging, and finally gamma radiation (5 kGy) treatment was developed. The developed combination process was found to reduce microbial load to below detectable level and quite effectively inactivated Aspergillusochraceus spores as well as pre-formed toxin. These treatments were not found to affect the contents of biochemical constituents such as total and reducing sugars, proteins, phenolics, and flavonoids during storage. Prophylactic properties in terms of antioxidant capacity and potential to suppress chemical induced mutagenesis were not affected in these samples. Physical properties and sensory qualities were also found to be similar to fresh (control). Thus, the developed combination process ensured microbiological safety and extended shelf life of sweet corn kernels up to 30 days at 4℃ . (author)

  8. Hurdles to herd immunity: Distrust of government and vaccine refusal in the US, 2002-2003.

    Lee, Charlotte; Whetten, Kathryn; Omer, Saad; Pan, William; Salmon, Daniel

    2016-07-25

    High rates of nonmedical exemptions (NMEs) from required childhood vaccinations have contributed to outbreaks of vaccine-preventable diseases, such as measles and pertussis. Understanding the parental decision to obtain an NME could help health professionals and public health programs improve vaccination rates in areas with high vaccine refusal. Using a 2002-2003 multi-state survey of parents of school age children (​n=2445), this study found that parental distrust of the government and of healthcare providers is a significant factor related to a number of vaccine-related beliefs and behaviors. The odds that parents who distrust the government have seen a complementary/alternative medicine (CAM) provider were 2.11 times greater than those of parents who trust the government (70.1% vs 52.6%; OR, 2.11; 95% CI, 1.59-2.84; Pgovernment had increased odds of trusting vaccine information from CAM providers compared to trusting parents (57.9% vs 46.3%; OR, 1.53; 95% CI, 1.16-2.01; Pgovernment also had increased odds of distrusting vaccine information acquired at their healthcare providers' offices (12.6% vs 4.7%; OR, 2.64; 95% CI, 1.64-4.24; Pgovernment sources of information about vaccines were unreliable, categorizing the CDC, the Food and Drug Administration (FDA), or local and state health departments as poor or very poor sources (distrust government vs trust government: 25.2% vs 11.7%; OR, 2.39; 95% CI, 1.70-3.36; Pgovernment and healthcare provider communications. Research into new and more effective techniques for delivering pro-vaccine messages is warranted. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. Social Influence and Cognitive-Motivational Effects on Terrorism Preparedness: A Hurdle Model

    Wirtz, Philip W.; Rohrbeck, Cynthia A.

    2017-01-01

    Objectives: The identification of factors which influence peoples' preparation for health safety risks posed by natural and man-made disasters is a central concern in health education. Prior studies have generally approached this issue from either a cognitive or a social influence perspective, and have failed to recognise the increased importance…

  10. T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy.

    Sackstein, Robert; Schatton, Tobias; Barthel, Steven R

    2017-06-01

    Advances in cancer immunotherapy have offered new hope for patients with metastatic disease. This unfolding success story has been exemplified by a growing arsenal of novel immunotherapeutics, including blocking antibodies targeting immune checkpoint pathways, cancer vaccines, and adoptive cell therapy (ACT). Nonetheless, clinical benefit remains highly variable and patient-specific, in part, because all immunotherapeutic regimens vitally hinge on the capacity of endogenous and/or adoptively transferred T-effector (T eff ) cells, including chimeric antigen receptor (CAR) T cells, to home efficiently into tumor target tissue. Thus, defects intrinsic to the multi-step T-cell homing cascade have become an obvious, though significantly underappreciated contributor to immunotherapy resistance. Conspicuous have been low intralesional frequencies of tumor-infiltrating T-lymphocytes (TILs) below clinically beneficial threshold levels, and peripheral rather than deep lesional TIL infiltration. Therefore, a T eff cell 'homing deficit' may arguably represent a dominant factor responsible for ineffective immunotherapeutic outcomes, as tumors resistant to immune-targeted killing thrive in such permissive, immune-vacuous microenvironments. Fortunately, emerging data is shedding light into the diverse mechanisms of immune escape by which tumors restrict T eff cell trafficking and lesional penetrance. In this review, we scrutinize evolving knowledge on the molecular determinants of T eff cell navigation into tumors. By integrating recently described, though sporadic information of pivotal adhesive and chemokine homing signatures within the tumor microenvironment with better established paradigms of T-cell trafficking under homeostatic or infectious disease scenarios, we seek to refine currently incomplete models of T eff cell entry into tumor tissue. We further summarize how cancers thwart homing to escape immune-mediated destruction and raise awareness of the potential impact of immune checkpoint blockers on T eff cell homing. Finally, we speculate on innovative therapeutic opportunities for augmenting T eff cell homing capabilities to improve immunotherapy-based tumor eradication in cancer patients, with special focus on malignant melanoma.

  11. Machine learning and hurdle models for improving regional predictions of stream water acid neutralizing capacity

    Nicholas A. Povak; Paul F. Hessburg; Keith M. Reynolds; Timothy J. Sullivan; Todd C. McDonnell; R. Brion Salter

    2013-01-01

    In many industrialized regions of the world, atmospherically deposited sulfur derived from industrial, nonpoint air pollution sources reduces stream water quality and results in acidic conditions that threaten aquatic resources. Accurate maps of predicted stream water acidity are an essential aid to managers who must identify acid-sensitive streams, potentially...

  12. Value Tools in Managed Care Decision Making: Current Hurdles and Future Opportunities.

    Schafer, Jeremy; Galante, Dominic; Shafrin, Jason

    2017-06-01

    Organizations such as the National Comprehensive Cancer Network, American Society of Clinical Oncology, Institute for Clinical and Economic Review, and Memorial Sloan Kettering have created distinct tools to help different stakeholders assess the value of oncology treatments. However, the oncology value tools were not necessarily created for payers, and it is unclear whether payers are using these tools as part of their drug management process. To understand what value tools payers are using in oncology management and what benefits and shortcomings the tools may have from the payer perspective. A survey targeting drug coverage decision makers at health plans was conducted in August 2016. Respondents attesting to using 2 or more value tools in drug management were eligible for an additional in-depth interview to understand the respondents' perceived benefits and shortcomings of current value tools. Respondents also were asked to describe desired attributes of a hypothetical payer-centric value tool. A total of 28 respondents representing approximately 160 million commercially insured medical lives completed the survey. Twenty respondents (71%) reported using at least 1 value tool in their drug management process. Twelve respondents (43%) used at least 2 tools, and 4 respondents (14%) used at least 3 tools. A total of 6 respondents were selected for in-depth interviews. Interviewees praised value tools for advancing the discussion on drug value and incorporating clinical evidence. However, interviewees felt available value tools varied on providing firm recommendations and relevant price benchmarks. Respondents most commonly recommended the following attributes of a proposed payer-centric value framework: taking a firm position on product value; product comparisons in lieu of comparative clinical trials; web-based tool access; and tool updates at least quarterly. Interview respondents also expressed some support for allowing manipulation of inputs and inclusion of quality-of-life and patient-reported outcome data. Although nearly half of payers surveyed use 2 or more value tools in the drug management process, payers identified a number of areas where the tools could be revised to increase their utility to payers. No outside funding or assistance of any kind was used for this research or in manuscript preparation. Schafer and Galante are employed by Precision for Value, a payer ad marketing agency that works exclusively with life science companies. Shafrin is employed by Precision Health Economics, a consulting company to insurance and life science industries. Shafer, along with Galante and Shafrin, contributed to study design, data collection, and manuscript preparation. The authors contributed equally to data analysis and interpretation and manuscript revision.

  13. Workplace Incivility a Hurdle in TQM Practices Implementation in Higher Education Institutes of Balochistan

    Ismail, Roqia; Ali, Muhammad

    2016-01-01

    The basic purpose of the study was to explore the influence of workplace incivility on the total quality management practices implementation in higher education institutes of balochistan. The data was collected through questionnaire and the sample size of the study was 381. The reliability and validity of the questionnaire was checked through…

  14. Hurdles of CAR-T cell-based cancer immunotherapy directed against solid tumors.

    Zhang, Bing-Lan; Qin, Di-Yuan; Mo, Ze-Ming; Li, Yi; Wei, Wei; Wang, Yong-Sheng; Wang, Wei; Wei, Yu-Quan

    2016-04-01

    Recent reports on the impressive efficacy of chimeric antigen receptor (CAR)-modified T cells against hematologic malignancies have inspired oncologists to extend these efforts for the treatment of solid tumors. Clinical trials of CAR-T-based cancer immunotherapy for solid tumors showed that the efficacies are not as remarkable as in the case of hematologic malignancies. There are several challenges that researchers must face when treating solid cancers with CAR-T cells, these include choosing an ideal target, promoting efficient trafficking and infiltration, overcoming the immunosuppressive microenvironment, and avoiding associated toxicity. In this review, we discuss the obstacles imposed by solid tumors on CAR-T cell-based immunotherapy and strategies adopted to improve the therapeutic potential of this approach. Continued investigations are necessary to improve therapeutic outcomes and decrease the adverse effects of CAR-T cell therapy in patients with solid malignancies in the future.

  15. Checklists in the operating room: Help or hurdle? A qualitative study on health workers' experiences

    Heltne Jon-Kenneth

    2010-12-01

    Full Text Available Abstract Background Checklists have been used extensively as a cognitive aid in aviation; now, they are being introduced in many areas of medicine. Although few would dispute the positive effects of checklists, little is known about the process of introducing this tool into the health care environment. In 2008, a pre-induction checklist was implemented in our anaesthetic department; in this study, we explored the nurses' and physicians' acceptance and experiences with this checklist. Method Focus group interviews were conducted with a purposeful sample of checklist users (nurses and physicians from the Department of Anaesthesia and Intensive Care in a tertiary teaching hospital. The interviews were analysed qualitatively using systematic text condensation. Results Users reported that checklist use could divert attention away from the patient and that it influenced workflow and doctor-nurse cooperation. They described senior consultants as both sceptical and supportive; a head physician with a positive attitude was considered crucial for successful implementation. The checklist improved confidence in unfamiliar contexts and was used in some situations for which it was not intended. It also revealed insufficient equipment standardisation. Conclusion Our findings suggest several issues and actions that may be important to consider during checklist use and implementation.

  16. METHODOLOGICAL HURDLES IN CAPTURING CMC DATA: THE CASE OF THE MISSING SELF-REPAIR

    Bryan Smith

    2008-02-01

    Full Text Available This paper reports on a study of the use of self-repair among learners of German in a task-based CMC environment. The purpose of the study was two-fold. The first goal sought to establish how potential interpretations of CMC data may be very different depending on the method of data collection and evaluation employed. The second goal was to explicitly examine the nature of CMC self-repair in the task-based foreign language CALL classroom. Paired participants (n=46 engaged in six jigsaw tasks over the course of one university semester via the chat function in Blackboard. Chat data were evaluated first by using only the chat log file and second by examining a video file of the screen capture of the entire interaction. Results show a fundamental difference in the interpretation of the chat interaction which varies as a function of the data collection and evaluation methods employed. The findings also suggest a possible difference in the nature of self-repair across face-to-face and SCMC environments. In view of the results, this paper calls for CALL researchers to abandon the reliance on printed chat log files when attempting to interpret SCMC interactional data.

  17. Using Robots to Motivate At-Risk Learners in Science over the Ninth Grade Hurdle

    Cerge, Dora

    The ninth grade is a pivotal year in an adolescent's academic career; however, educators have failed to find a remedy for the high failure and dropout rates at this grade level. Students who lack basic skills and support as they enter high school can experience repeated failures, which often lead to a decrease in motivation and dropping out of school. Up to 15% of all ninth graders repeat ninth grade and 36% of all U. S. dropouts are ninth graders. It is imperative that researchers and educators find new ways to motivate at-risk students and augment basic skills in order to mitigate the dropout problem at this grade level. Robot teachers could be a viable solution to increase student motivation and achievement. However, before such strategies could be recommended for implementation, information about their efficacy in a high school setting is needed. The purpose of this quantitative, two-group experimental, pretest-posttest study was to determine the effects of a robot teacher/instructor on science motivation and science achievement in ninth grade at-risk learners. Approximately 40 at-risk, repeating ninth graders, ranging in age from 13 to 17 years old from one high school in the United States Virgin Islands, participated in the study. Half of the students received a robot teacher/instructor manipulation whereby a robot taught a science lesson for physical science assessments (experimental group), and the other half received the same instruction from a human teacher (control group). An analysis of covariance (ANCOVA) was used to compare the science achievement posttest scores, as measured by test scores, and science motivation posttest scores, as measured by the SMTSL, between the experimental and the control groups, while controlling for the pretest scores (covariate). The results demonstrated that posttest motivation and achievement scores in the human teacher condition were not significantly different than posttest motivation scores in the robot teacher condition. The current findings add to the literature and suggest that although a brief session with a robot teacher does not lead to a significant increase in motivation or academic achievement in an at-risk ninth grade population; it also does not lead to a significant decrease in motivation or academic achievment, making the use of robotic instructors a possible viable solution in situations where the procurement of quality teachers is difficult. Recommendations for practice include using robots as assistants in small study groups, where qualified teachers are not available, or as substitutes. The most important recommendations for future research include extending the duration of robotic manipulation, increasing the manipulation period for robotic instruction, and increasing the sample size.

  18. T-ray spectroscopy of biomolecules: from chemical recognition toward biochip analysis - horizons and hurdles

    Fischer, Bernd M.; Helm, Hanspeter; Jepsen, Peter Uhd

    2006-01-01

    In the recent years, there has been an increased interest in the exploitation of the far-infrared spectral region for applications based on chemical recognition. The fact that on the one hand many packaging materials are transparent for THz radiation and on the other hand the THz-spectra of many ...

  19. Navigating Declining Budgets, Political Hurdles: A New Vision for the Future of Geoscience

    Gagosian, Robert B.

    2013-06-01

    The Oklahoma tornadoes, Superstorm Sandy, the Tohoku tsunami, and the Deepwater Horizon oil spill are just a few examples of oceanic, atmospheric, and other Earth system disasters in the past 3 years that together claimed thousands of lives and caused hundreds of billions of dollars of damage. Basic and applied research in the geosciences were essential in supporting early warnings and forecasts that were used not only to protect lives when these natural disasters struck but also to assess risks and help society to be better able to adapt and recover after disaster struck.

  20. Overcoming the hurdles of multi-step targeting (MST) for effective radioimmunotherapy of solid tumors

    Larson, Steven M.; Cheung, Nai-Kong

    2009-01-01

    The 4 specific aims of this project are: (1) Optimization of MST to increase tumor uptake; (2) Antigen heterogeneity; (3) Characterization and reduction of renal uptake; and (4) Validation in vivo of optimized MST targeted therapy. This proposal focussed upon optimizing multistep immune targeting strategies for the treatment of cancer. Two multi-step targeting constructs were explored during this funding period: (1) anti-Tag-72 and (2) anti-GD2.

  1. Persistently High Hip Circumference after Bariatric Surgery Is a Major Hurdle to Successful Hip Replacement

    Menachem M. Meller

    2014-01-01

    Full Text Available The prevalence of class III obesity (BMI≥40 kg/m2 in black women is 18%. As class III obesity leads to hip joint deterioration, black women frequently present for orthopedic care. Weight loss associated with bariatric surgery should lead to enhanced success of hip replacements. However, we present a case of a black woman who underwent Roux-en-Y gastric bypass with the expectation that weight loss would make her a better surgical candidate for hip replacement. Her gastric bypass was successful as her BMI declined from 52.0 kg/m2 to 33.7 kg/m2. However, her hip circumference after weight loss remained persistently high. Therefore, at surgery the soft tissue tunnel geometry presented major challenges. Tunnel depth and immobility of the soft tissue interfered with retractor placement, tissue reflection, and surgical access to the acetabulum. Therefore a traditional cup placement could not be achieved. Instead, a hemiarthroplasty was performed. After surgery her pain and reliance on external support decreased. But her functional independence never improved. This case demonstrates that a lower BMI after bariatric surgery may improve the metabolic profile and decrease anesthesia risk, but the success of total hip arthroplasties remains problematic if fat mass in the operative field (i.e., high hip circumference remains high.

  2. Gender equality in India hit by illiteracy, child marriages and violence: a hurdle for sustainable development.

    Brahmapurkar, Kishor Parashramji

    2017-01-01

    Gender equality is fundamental to accelerate sustainable development. It is necessary to conduct gender analyses to identify sex and gender-based differences in health risks. This study aimed to find the gender equality in terms of illiteracy, child marriages and spousal violence among women based on data from National Family Health Survey 2015-16 (NFHS-4). This was a descriptive analysis of secondary data of ever-married women onto reproductive age from 15 states and 3 UTs in India of the first phase of NFHS-4. Gender gap related to literacy and child marriage among urban and rural area was compared. In rural area all states except Meghalaya and Sikkim had the significantly higher percentage of women's illiteracy as compared to male. Bihar and Madhya Pradesh had higher illiterate women, 53.7% and 48.6% as compared to male, 24.7% and 21.5% respectively (P gender gap between illiteracy with women more affected in rural areas with higher prevalence of child marriages and poor utilization of maternal health services. Also, violence against women is showing an upward trend with declining sex-ratio at birth.

  3. Mission Command and the United States Navy: Overcoming Doctrinal Hurdles to Enable Mission Command

    2017-05-12

    directives , would drive sweeping selection , training, education, and personnel management changes. Leaders would be assessed and selected into the...MONITOR’S REPORT 11. SPONSOR/MONITOR’S EP T NUMBER(S) 12. DISTRIBUTION / AVAILABILITY STATEMENT For Example : Distribution Statement A: Approved for...public release; Distribution is unlimited. Reference: DOD Directive 5230.24 13. SUPPLEMENTARY NOTES A paper submitted to the Naval War

  4. Global brain storming : oil companies increasingly tap collective intelligence to overcome technology hurdles

    Smith, M.

    2009-04-15

    This article described a novel exploration approach that Toronto-based Goldcorp Inc. took a decade ago when it placed its geological data on the web for a mass collaboration effort among the global community of geologists to identify potential drilling sites. The move resulted in the identification of 110 targets, of which half were entirely new to Goldcorp, and of which four in five struck considerable quantities of gold. The article emphasized that the computer network offers a power that has not yet been fully tapped. It described other companies that have followed suite in finding solutions to proprietary challenges, including Schlumberger, Deloro Resources Ltd., Electro-Petroleum Inc., and Proctor and Gamble Inc. among others. The Web 2.0, which serves as a platform for a range of applications, can also be used for open-source science or global brainstorming. While the idea of open innovation was a novelty a year or two ago, it has now become a necessity. InnoCentive solved a long-standing oil spill problem when a chemist from the web with no ties to the oil industry suggested a way to handle the spill. The Cordova, Alaska-based Oil Spill Recovery Institute has also sought solutions for oil spills and novel boom designs. It was concluded that at a time when research and development budgets in the petroleum industry are being cut, open innovation facilitators stand to benefit. This cross-industry collaboration does not involve geoscientists alone. Rather, it includes people from completely different fields of expertise, experience or education who can add to the real issues that the oil industry needs to address and change. 1 ref.

  5. One more hurdle to increasing mammography screening: pubescent, adolescent, and prior mammography screening experiences.

    Thomas, Eileen; Usher, LaToya

    2009-01-01

    Approximately $8.1 billion dollars is spent each year in the United States alone on the treatment of breast cancer. Survival rates are dependent on access to, and utilization of, early detection services. The primary reason for disparity in breast cancer mortality is the delay in time to diagnosis, resulting in poor prognosis. Despite ongoing research to understand barriers to mammography screening, recent studies report a decrease in mammography screening among all racial groups. A qualitative approach was used to elicit information from 36 White non- Hispanic, African-American, Hispanic, and Native American women without a history of breast cancer. Women were invited to share written or audiotape-recorded narratives about experiences pertaining to their breasts and their mammography screening experiences. Major categories identified were: teasing, family norms and values, media/societal influence, body image, and mammography screening experiences. The resulting effects of these experiences left these women with feelings of shame and "conflict" regarding their breasts. The major theme identified was breast conflict. Findings suggest that breast conflict may persist throughout the lifespan and can have a negative influence on a woman's decision to participate in mammography screening. The authors hypothesize that experiences that occur during adolescence pertaining to young girls' breasts can influence a women's body image, which in turn can later in life affect health-seeking behaviors related to mammography screening. These findings have implications for public health practice in planning for breast cancer screening, education, and interventions for women from diverse racial/ethnics groups.

  6. Focused Ultrasound for Essential Tremor: Review of the Evidence and Discussion of Current Hurdles

    Mohammad Rohani

    2017-05-01

    Full Text Available Background. While there is no breakthrough progress in the medical treatment of essential tremor (ET, in the past decades several remarkable achievements happened in the surgical field, such as radiofrequency thalamotomy, thalamic deep brain stimulation and gamma knife thalamotomy. The most recent advance in this area is magnetic resonance-guided focused ultrasound (MRgFUS. Methods. Purpose of this review is to discuss the new developments and trials of MRgFUS in the treatment of ET and other tremor disorders. Results. MRgFUS is an incision-less surgery performed without anesthesia and ionizing radiation (no risk of cumulative dose and delayed side effects. Studies have shown the safety and effectiveness of unilateral MRgFUS-thalamotomy in the treatment of ET. It has been successfully used in few patients with Parkinson's disease-related tremor and fewer patients with Fragile X-associated Tremor/Ataxia Syndrome. Safety and long-term effects of the procedure are still unclear, as temporary and permanent adverse events have been reported as well as reoccurrence of tremor. Discussion. MRgFUS is a promising new surgical approach with still a number of unknowns and unsolved issues. It represents a valuable option particularly for patients who refused or could not be candidate for other procedures, deep brain stimulation in particular. 

  7. Allergenicity assessment of apple cultivars: hurdles in quantifying labile fruit allergens

    Zuidmeer, L.; van Leeuwen, W. A.; Kleine Budde, I.; Breiteneder, H.; Ma, Y.; Mills, C.; Sancho, A. I.; Meulenbroek, E. J.; van de Weg, E.; Gilissen, L.; Ferreira, F.; Hoffmann-Sommergruber, K.; van Ree, R.

    2006-01-01

    BACKGROUND: Assessment of allergenicity of foods is important for allergic consumers and regulators. Immunoassays to measure major food allergens are widely applied, often giving variable results. Using the major apple allergen Mal d 1 as a model, we aimed to establish at the molecular level why

  8. Robotic-assisted single-port donor nephrectomy using the da Vinci single-site platform.

    LaMattina, John C; Alvarez-Casas, Josue; Lu, Irene; Powell, Jessica M; Sultan, Samuel; Phelan, Michael W; Barth, Rolf N

    2018-02-01

    Although single-port donor nephrectomy offers improved cosmetic outcomes, technical challenges have limited its application to selected centers. Our center has performed over 400 single-port donor nephrectomies. The da Vinci single-site robotic platform was utilized in an effort to overcome the steric, visualization, ergonomic, and other technical limitations associated with the single-port approach. Food and Drug Administration device exemption was obtained. Selection criteria for kidney donation included body mass index da Vinci single-site platform. Our experience supported the safety of this approach but found that the technology added cost and complexity without tangible benefit. Development of articulating instruments, energy, and stapling devices will be necessary for increased application of robotic single-site surgery for donor nephrectomy. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Single-pulse and multi-pulse femtosecond laser damage of optical single films

    Yuan Lei; Zhao Yuan'an; He Hongbo; Shao Jianda; Fan Zhengxiu

    2006-01-01

    Laser-induced damage of a single 500 nm HfO 2 film and a single 500 nm ZrO 2 film were studied with single- and multi-pulse femtosecond laser. The laser-induced damage thresholds (LIDT) of both samples by the 1-on-1 method and the 1000-on-1 method were reported. It was discovered that the LIDT of the HfO 2 single film was higher than that of the ZrO 2 single film by both test methods, which was explained by simple Keldysh's multiphoton ionization theory. The LIDT of multi-pulse was lower than that of single-pulse for both samples as a result of accumulative effect. (authors)

  10. Technologies for Single-Cell Isolation.

    Gross, Andre; Schoendube, Jonas; Zimmermann, Stefan; Steeb, Maximilian; Zengerle, Roland; Koltay, Peter

    2015-07-24

    The handling of single cells is of great importance in applications such as cell line development or single-cell analysis, e.g., for cancer research or for emerging diagnostic methods. This review provides an overview of technologies that are currently used or in development to isolate single cells for subsequent single-cell analysis. Data from a dedicated online market survey conducted to identify the most relevant technologies, presented here for the first time, shows that FACS (fluorescence activated cell sorting) respectively Flow cytometry (33% usage), laser microdissection (17%), manual cell picking (17%), random seeding/dilution (15%), and microfluidics/lab-on-a-chip devices (12%) are currently the most frequently used technologies. These most prominent technologies are described in detail and key performance factors are discussed. The survey data indicates a further increasing interest in single-cell isolation tools for the coming years. Additionally, a worldwide patent search was performed to screen for emerging technologies that might become relevant in the future. In total 179 patents were found, out of which 25 were evaluated by screening the title and abstract to be relevant to the field.

  11. Single Molecule Spectroscopy of Electron Transfer

    Holman, Michael; Zang, Ling; Liu, Ruchuan; Adams, David M.

    2009-01-01

    The objectives of this research are threefold: (1) to develop methods for the study electron transfer processes at the single molecule level, (2) to develop a series of modifiable and structurally well defined molecular and nanoparticle systems suitable for detailed single molecule/particle and bulk spectroscopic investigation, (3) to relate experiment to theory in order to elucidate the dependence of electron transfer processes on molecular and electronic structure, coupling and reorganization energies. We have begun the systematic development of single molecule spectroscopy (SMS) of electron transfer and summaries of recent studies are shown. There is a tremendous need for experiments designed to probe the discrete electronic and molecular dynamic fluctuations of single molecules near electrodes and at nanoparticle surfaces. Single molecule spectroscopy (SMS) has emerged as a powerful method to measure properties of individual molecules which would normally be obscured in ensemble-averaged measurement. Fluctuations in the fluorescence time trajectories contain detailed molecular level statistical and dynamical information of the system. The full distribution of a molecular property is revealed in the stochastic fluctuations, giving information about the range of possible behaviors that lead to the ensemble average. In the case of electron transfer, this level of understanding is particularly important to the field of molecular and nanoscale electronics: from a device-design standpoint, understanding and controlling this picture of the overall range of possible behaviors will likely prove to be as important as designing ia the ideal behavior of any given molecule.

  12. Technologies for Single-Cell Isolation

    Gross, Andre; Schoendube, Jonas; Zimmermann, Stefan; Steeb, Maximilian; Zengerle, Roland; Koltay, Peter

    2015-01-01

    The handling of single cells is of great importance in applications such as cell line development or single-cell analysis, e.g., for cancer research or for emerging diagnostic methods. This review provides an overview of technologies that are currently used or in development to isolate single cells for subsequent single-cell analysis. Data from a dedicated online market survey conducted to identify the most relevant technologies, presented here for the first time, shows that FACS (fluorescence activated cell sorting) respectively Flow cytometry (33% usage), laser microdissection (17%), manual cell picking (17%), random seeding/dilution (15%), and microfluidics/lab-on-a-chip devices (12%) are currently the most frequently used technologies. These most prominent technologies are described in detail and key performance factors are discussed. The survey data indicates a further increasing interest in single-cell isolation tools for the coming years. Additionally, a worldwide patent search was performed to screen for emerging technologies that might become relevant in the future. In total 179 patents were found, out of which 25 were evaluated by screening the title and abstract to be relevant to the field. PMID:26213926

  13. Technologies for Single-Cell Isolation

    Andre Gross

    2015-07-01

    Full Text Available The handling of single cells is of great importance in applications such as cell line development or single-cell analysis, e.g., for cancer research or for emerging diagnostic methods. This review provides an overview of technologies that are currently used or in development to isolate single cells for subsequent single-cell analysis. Data from a dedicated online market survey conducted to identify the most relevant technologies, presented here for the first time, shows that FACS (fluorescence activated cell sorting respectively Flow cytometry (33% usage, laser microdissection (17%, manual cell picking (17%, random seeding/dilution (15%, and microfluidics/lab-on-a-chip devices (12% are currently the most frequently used technologies. These most prominent technologies are described in detail and key performance factors are discussed. The survey data indicates a further increasing interest in single-cell isolation tools for the coming years. Additionally, a worldwide patent search was performed to screen for emerging technologies that might become relevant in the future. In total 179 patents were found, out of which 25 were evaluated by screening the title and abstract to be relevant to the field.

  14. Diamond-based single-photon emitters

    Aharonovich, I; Castelletto, S; Simpson, D A; Su, C-H; Greentree, A D; Prawer, S

    2011-01-01

    The exploitation of emerging quantum technologies requires efficient fabrication of key building blocks. Sources of single photons are extremely important across many applications as they can serve as vectors for quantum information-thereby allowing long-range (perhaps even global-scale) quantum states to be made and manipulated for tasks such as quantum communication or distributed quantum computation. At the single-emitter level, quantum sources also afford new possibilities in terms of nanoscopy and bio-marking. Color centers in diamond are prominent candidates to generate and manipulate quantum states of light, as they are a photostable solid-state source of single photons at room temperature. In this review, we discuss the state of the art of diamond-based single-photon emitters and highlight their fabrication methodologies. We present the experimental techniques used to characterize the quantum emitters and discuss their photophysical properties. We outline a number of applications including quantum key distribution, bio-marking and sub-diffraction imaging, where diamond-based single emitters are playing a crucial role. We conclude with a discussion of the main challenges and perspectives for employing diamond emitters in quantum information processing.

  15. Investigation on single carbon atom transporting through the single-walled carbon nanotube by MD simulation

    Ding Yinfeng; Zhang Zhibin; Ke Xuezhi; Zhu Zhiyuan; Zhu Dezhang; Wang Zhenxia; Xu Hongjie

    2005-01-01

    The single carbon atom transporting through the single-walled carbon nanotube has been studied by molecular-dynamics (MD) simulation. We got different trajectories of the carbon atom by changing the input parameters. The simulation results indicate that the single carbon atom with low energy can transport through the carbon nanotube under some input conditions and result in different trajectories being straight line or 'rosette' or circular. (authors)

  16. Controlled generation of a single Trichel pulse and a series of single Trichel pulses in air

    Mizeraczyk, Jerzy; Berendt, Artur; Akishev, Yuri

    2018-04-01

    In this paper, a simple method for the controlled generation of a single Trichel pulse or a series of single Trichel pulses of a regulated repetition frequency in air is proposed. The concept of triggering a single Trichel pulse or a series of such pulses is based on the precise controlling the voltage inception of the negative corona, which can be accomplished through the use of a ramp voltage pulse or a series of such pulses with properly chosen ramp voltage pulse parameters (rise and fall times, and ramp voltage pulse repetition frequency). The proposal has been tested in experiments using a needle-to-plate electrode arrangement in air, and reproducible Trichel pulses (single or in a series) were obtained by triggering them with an appropriately designed voltage waveform. The proposed method and results obtained have been qualitatively analysed. The analysis provides guidance for designing the voltage ramp pulse in respect of the generation of a single Trichel pulse or a series of single Trichel pulses. The controlled generation of a single Trichel pulse or a series of such pulses would be a helpful research tool for the refined studies of the fundamental processes in a negative corona discharge in a single- (air is an example) and multi-phase gaseous fluids. The controlled generation of a single Trichel pulse or a series of Trichel pulses can also be attractive for those corona treatments which need manipulation of the electric charge and heat portions delivered by the Trichel pulses to the object.

  17. An automatic single channel analyzer based on single-chip microcomputer

    Yan Xuekun; Jia Mingchun; Zhang Yan; Liu Mingjian; Luo Ming

    2008-01-01

    The hardware and software of an automatic single channel analyzer based on AT89C51RC single-chip microcomputer is described in this paper. The equipment takes a method of channel-width-adjusting symmetrically, and makes use of single-chip microcomputer to control the two DAC0832 so as to adjust the discriminating threshold and channel-width automatically. As a result, the auto-measuring of the single channel analyzer is realized. Its circuit configuration is simple, and the uniformity of its channel-width is well, too. (authors)

  18. A novel high-efficiency single-mode quantum dot single photon source

    Gerard, J.M.; Gregersen, Niels; Nielsen, Torben Roland

    2008-01-01

    We present a novel single-mode single photon source exploiting the emission of a semiconductor quantum dot (QD) located inside a photonic wire. Besides an excellent coupling (>95%) of QD spontaneous emission to the fundamental guided mode [1], we show that a single photon collection efficiency...... above 80% within a 0.5 numerical aperture can be achieved using a bottom Bragg mirror and a tapering of the nanowire tip. Because this photon collection strategy does not exploit the Purcell effect, it could also be efficiently applied to broadband single photon emitters such as F-centers in diamond....

  19. Fast recognition of single molecules based on single-event photon statistics

    Dong Shuangli; Huang Tao; Liu Yuan; Wang Jun; Zhang Guofeng; Xiao Liantuan; Jia Suotang

    2007-01-01

    Mandel's Q parameter, which is determined from single-event photon statistics, provides an alternative way to recognize single molecules with fluorescence detection, other than the second-order correlation function. It is shown that the Q parameter of an assumed ideal double-molecule fluorescence with the same average photon number as that of the sample fluorescence can act as the criterion for single-molecule recognition. The influence of signal-to-background ratio and the error estimates for photon statistics are also presented. We have applied this method to ascertain single Cy5 dye molecules within hundreds of milliseconds

  20. Single-base resolution and long-coverage sequencing based on single-molecule nanomanipulation

    An Hongjie; Huang Jiehuan; Lue Ming; Li Xueling; Lue Junhong; Li Haikuo; Zhang Yi; Li Minqian; Hu Jun

    2007-01-01

    We show new approaches towards a novel single-molecule sequencing strategy which consists of high-resolution positioning isolation of overlapping DNA fragments with atomic force microscopy (AFM), subsequent single-molecule PCR amplification and conventional Sanger sequencing. In this study, a DNA labelling technique was used to guarantee the accuracy in positioning the target DNA. Single-molecule multiplex PCR was carried out to test the contamination. The results showed that the two overlapping DNA fragments isolated by AFM could be successfully sequenced with high quality and perfect contiguity, indicating that single-base resolution and long-coverage sequencing have been achieved simultaneously

  1. Coherent single-photon absorption by single emitters coupled to one-dimensional nanophotonic waveguides

    Chen Yuntian; Wubs, Martijn; Moerk, Jesper [DTU Fotonik, Department of Photonics Engineering, Oersteds Plads, DK-2800 Kgs Lyngby (Denmark); Koenderink, A Femius, E-mail: yche@fotonik.dtu.dk [Center for Nanophotonics, FOM Institute for Atomic and Molecular Physics (AMOLF), Science Park 104, 1098 XG Amsterdam (Netherlands)

    2011-10-15

    We study the dynamics of single-photon absorption by a single emitter coupled to a one-dimensional waveguide that simultaneously provides channels for spontaneous emission (SE) decay and a channel for the input photon. We have developed a time-dependent theory that allows us to specify any input single-photon wavepacket guided by the waveguide as the initial condition, and calculate the excitation probability of the emitter, as well as the time evolution of the transmitted and reflected fields. For single-photon wavepackets with a Gaussian spectrum and temporal shape, we obtain analytical solutions for the dynamics of absorption, with maximum atomic excitation {approx}40%. We furthermore propose a terminated waveguide to aid the single-photon absorption. We found that for an emitter placed at an optimal distance from the termination, the maximum atomic excitation due to an incident single-photon wavepacket can exceed 70%. This high value is a direct consequence of the high SE {beta}-factor for emission into the waveguide. Finally, we have also explored whether waveguide dispersion could aid single-photon absorption by pulse shaping. For a Gaussian input wavepacket, we found that the absorption efficiency can be improved by a further 4% by engineering the dispersion. Efficient single-photon absorption by a single emitter has potential applications in quantum communication and quantum computation. (paper)

  2. β-Thalassemia mutations and hemoglobinopathies in Adana, Turkey: results from a single center study

    Guvenc, Birol; Canataroglu, Abdullah; Unsal, Cagatay; Yildiz, Sule Menziletoglu; Turhan, Ferda Tekin; Bozdogan, Sevcan Tug; Dincer, Suleyman; Erkman, Hakan

    2012-01-01

    Introduction β-Thalassemia and hemoglobinopathies are common genetic disorders in Turkey and in this retrospective study our aim was to determine the frequency of β-thalassemia and hemoglobinopathies in Adana, which is one of the biggest cities located in the southern part of Turkey. Material and methods Data from 3000 individuals admitted to Seyhan Hereditary Blood Disorders Center in Adana were evaluated. The blood samples were collected into EDTA-containing tubes and hematological paramete...

  3. Single DNA denaturation and bubble dynamics

    Metzler, Ralf; Ambjörnsson, Tobias; Hanke, Andreas

    2009-01-01

    While the Watson-Crick double-strand is the thermodynamically stable state of DNA in a wide range of temperature and salt conditions, even at physiological conditions local denaturation bubbles may open up spontaneously due to thermal activation. By raising the ambient temperature, titration......, or by external forces in single molecule setups bubbles proliferate until full denaturation of the DNA occurs. Based on the Poland-Scheraga model we investigate both the equilibrium transition of DNA denaturation and the dynamics of the denaturation bubbles with respect to recent single DNA chain experiments...... for situations below, at, and above the denaturation transition. We also propose a new single molecule setup based on DNA constructs with two bubble zones to measure the bubble coalescence and extract the physical parameters relevant to DNA breathing. Finally we consider the interplay between denaturation...

  4. Autonomous calibration of single spin qubit operations

    Frank, Florian; Unden, Thomas; Zoller, Jonathan; Said, Ressa S.; Calarco, Tommaso; Montangero, Simone; Naydenov, Boris; Jelezko, Fedor

    2017-12-01

    Fully autonomous precise control of qubits is crucial for quantum information processing, quantum communication, and quantum sensing applications. It requires minimal human intervention on the ability to model, to predict, and to anticipate the quantum dynamics, as well as to precisely control and calibrate single qubit operations. Here, we demonstrate single qubit autonomous calibrations via closed-loop optimisations of electron spin quantum operations in diamond. The operations are examined by quantum state and process tomographic measurements at room temperature, and their performances against systematic errors are iteratively rectified by an optimal pulse engineering algorithm. We achieve an autonomous calibrated fidelity up to 1.00 on a time scale of minutes for a spin population inversion and up to 0.98 on a time scale of hours for a single qubit π/2 -rotation within the experimental error of 2%. These results manifest a full potential for versatile quantum technologies.

  5. Handbook of Single-Molecule Biophysics

    Hinterdorfer, Peter

    2009-01-01

    The last decade has seen the development of a number of novel biophysical methods that allow the manipulation and study of individual biomolecules. The ability to monitor biological processes at this fundamental level of sensitivity has given rise to an improved understanding of the underlying molecular mechanisms. Through the removal of ensemble averaging, distributions and fluctuations of molecular properties can be characterized, transient intermediates identified, and catalytic mechanisms elucidated. By applying forces on biomolecules while monitoring their activity, important information can be obtained on how proteins couple function to structure. The Handbook of Single-Molecule Biophysics provides an introduction to these techniques and presents an extensive discussion of the new biological insights obtained from them. Coverage includes: Experimental techniques to monitor and manipulate individual biomolecules The use of single-molecule techniques in super-resolution and functional imaging Single-molec...

  6. THE BERTRAND MODEL OF THE SINGLE MARKET

    Vadasan Ioana

    2010-12-01

    Full Text Available Starting with the signification of the rationality hypothesis when the agent’s contentment is directly affected by the other agents’ decisions, the theory of games defines solutions for solving different situations of conflict. The economic actors have different behaviours of the Single Market. Oligopoly strategic behaviours were analysed by the Bertrand model. The two types revealed in the work show that strategic interactions are sensitive to the companies’ features, products and markets. Regarding the situation when we have an oligopoly competition, the companies make interdependent decisions in the environment affected by risk and uncertainty of the Single Market. For this reason it is an opportunity to study the structure of oligopoly type of of the Single Market with the aid of non – cooperative games.

  7. Torque Measurement at the Single Molecule Level

    Forth, Scott; Sheinin, Maxim Y.; Inman, James; Wang, Michelle D.

    2017-01-01

    Methods for exerting and measuring forces on single molecules have revolutionized the study of the physics of biology. However, it is often the case that biological processes involve rotation or torque generation, and these parameters have been more difficult to access experimentally. Recent advances in the single molecule field have led to the development of techniques which add the capability of torque measurement. By combining force, displacement, torque, and rotational data, a more comprehensive description of the mechanics of a biomolecule can be achieved. In this review, we highlight a number of biological processes for which torque plays a key mechanical role. We describe the various techniques that have been developed to directly probe the torque experienced by a single molecule, and detail a variety of measurements made to date using these new technologies. We conclude by discussing a number of open questions and propose systems of study which would be well suited for analysis with torsional measurement techniques. PMID:23541162

  8. Single-particle Schroedinger fluid. I. Formulation

    Kan, K.K.; Griffin, J.J.

    1976-01-01

    The problem of a single quantal particle moving in a time-dependent external potential well is formulated specifically to emphasize and develop the fluid dynamical aspects of the matter flow. This idealized problem, the single-particle Schroedinger fluid, is shown to exhibit already a remarkably rich variety of fluid dynamical features, including compressible flow and line vortices. It provides also a sufficient framework to encompass simultaneously various simplified fluidic models for nuclei which have earlier been postulated on an ad hoc basis, and to illuminate their underlying restrictions. Explicit solutions of the single-particle Schroedinger fluid problem are studied in the adiabatic limit for their mathematical and physical implications (especially regarding the collective kinetic energy). The basic generalizations for extension of the treatment to the many-body Schroedinger fluid are set forth

  9. On theory of single-molecule transistor

    Tran Tien Phuc

    2009-01-01

    The results of the study on single-molecule transistor are mainly investigated in this paper. The structure of constructed single-molecule transistor is similar to a conventional MOSFET. The conductive channel of the transistors is a single-molecule of halogenated benzene derivatives. The chemical simulation software CAChe was used to design and implement for the essential parameter of the molecules utilized as the conductive channel. The GUI of Matlab has been built to design its graphical interface, calculate and plot the output I-V characteristic curves for the transistor. The influence of temperature, length and width of the conductive channel, and gate voltage is considered. As a result, the simulated curves are similar to the traditional MOSFET's. The operating temperature range of the transistors is wider compared with silicon semiconductors. The supply voltage for transistors is only about 1 V. The size of transistors in this research is several nanometers.

  10. Acoustic effects of single electrostatic discharges

    Orzech, Łukasz

    2015-01-01

    Electric discharges, depending on their character, can emit different types of energy, resulting in different effects. Single electrostatic discharges besides generation of electromagnetic pulses are also the source of N acoustic waves. Their specified parameters depending on amount of discharging charge enable determination of value of released charge in a function of acoustic descriptor (e.g. acoustic pressure). Presented approach is the basics of acoustic method for measurement of single electrostatic discharges, enabling direct and contactless measurement of value of charge released during ESD. Method for measurement of acoustic effect of impact of a single electrostatic discharge on the environment in a form of pressure shock wave and examples of acoustic descriptors in a form of equation Q=f(p a ) are described. The properties of measuring system as well as the results of regression static analyses used to determine the described relationships are analysed in details. (paper)

  11. Microplastic relaxations of single and polycrystalline molybdenum

    Pichl, W.; Weiss, B. [Wien Univ. (Austria). Inst. fuer Materialphysik; Chen, D.L.

    1998-05-01

    The microplasticity of high-purity molybdenum single crystals and of Mo polycrystals of technical purity has been investigated by relaxation step tests in uniaxial compression. A new model for the evaluation of relaxation tests in the microplastic range of b.c.c metals is presented which takes into account the decrease of the mobile dislocation density due to exhaustion of non-screw dislocations. The model allows an independent determination of the activation volume and of the microstructure parameters controlling dislocation exhaustion. The results indicate that in the high-purity single crystals the deformation rate is controlled by interactions of non-screw dislocations with the grown-in network. In the polycrystals additional interactions with impurity atoms seem to occur. In the single crystals the activity and subsequent exhaustion of two different glide systems was observed, followed by a gradual onset of screw dislocation motion. (orig.) 26 refs.

  12. Solid-state single-photon emitters

    Aharonovich, Igor; Englund, Dirk; Toth, Milos

    2016-10-01

    Single-photon emitters play an important role in many leading quantum technologies. There is still no 'ideal' on-demand single-photon emitter, but a plethora of promising material systems have been developed, and several have transitioned from proof-of-concept to engineering efforts with steadily improving performance. Here, we review recent progress in the race towards true single-photon emitters required for a range of quantum information processing applications. We focus on solid-state systems including quantum dots, defects in solids, two-dimensional hosts and carbon nanotubes, as these are well positioned to benefit from recent breakthroughs in nanofabrication and materials growth techniques. We consider the main challenges and key advantages of each platform, with a focus on scalable on-chip integration and fabrication of identical sources on photonic circuits.

  13. Single-particle dispersion in compressible turbulence

    Zhang, Qingqing; Xiao, Zuoli

    2018-04-01

    Single-particle dispersion statistics in compressible box turbulence are studied using direct numerical simulation. Focus is placed on the detailed discussion of effects of the particle Stokes number and turbulent Mach number, as well as the forcing type. When solenoidal forcing is adopted, it is found that the single-particle dispersion undergoes a transition from the ballistic regime at short times to the diffusive regime at long times, in agreement with Taylor's particle dispersion argument. The strongest dispersion of heavy particles is announced when the Stokes number is of order 1, which is similar to the scenario in incompressible turbulence. The dispersion tends to be suppressed as the Mach number increases. When hybrid solenoidal and compressive forcing at a ratio of 1/2 is employed, the flow field shows apparent anisotropic property, characterized by the appearance of large shock wave structures. Accordingly, the single-particle dispersion shows extremely different behavior from the solenoidal forcing case.

  14. Single Photon Sources in Silicon Carbide

    Brett Johnson

    2014-01-01

    Single photon sources in semiconductors are highly sought after as they constitute the building blocks of a diverse range of emerging technologies such as integrated quantum information processing, quantum metrology and quantum photonics. In this presentation, we show the first observation of single photon emission from deep level defects in silicon carbide (SiC). The single photon emission is photo-stable at room temperature and surprisingly bright. This represents an exciting alternative to diamond color centers since SiC possesses well-established growth and device engineering protocols. The defect is assigned to the carbon vacancy-antisite pair which gives rise to the AB photoluminescence lines. We discuss its photo-physical properties and their fabrication via electron irradiation. Preliminary measurements on 3C SiC nano-structures will also be discussed. (author)

  15. Theory of Single Point Incremental Forming

    Martins, P.A.F.; Bay, Niels; Skjødt, Martin

    2008-01-01

    This paper presents a closed-form theoretical analysis modelling the fundamentals of single point incremental forming and explaining the experimental and numerical results available in the literature for the past couple of years. The model is based on membrane analysis with bi-directional in-plan......-plane contact friction and is focused on the extreme modes of deformation that are likely to be found in single point incremental forming processes. The overall investigation is supported by experimental work performed by the authors and data retrieved from the literature.......This paper presents a closed-form theoretical analysis modelling the fundamentals of single point incremental forming and explaining the experimental and numerical results available in the literature for the past couple of years. The model is based on membrane analysis with bi-directional in...

  16. Single molecule transcription profiling with AFM

    Reed, Jason; Mishra, Bud; Pittenger, Bede; Magonov, Sergei; Troke, Joshua; Teitell, Michael A; Gimzewski, James K

    2007-01-01

    Established techniques for global gene expression profiling, such as microarrays, face fundamental sensitivity constraints. Due to greatly increasing interest in examining minute samples from micro-dissected tissues, including single cells, unorthodox approaches, including molecular nanotechnologies, are being explored in this application. Here, we examine the use of single molecule, ordered restriction mapping, combined with AFM, to measure gene transcription levels from very low abundance samples. We frame the problem mathematically, using coding theory, and present an analysis of the critical error sources that may serve as a guide to designing future studies. We follow with experiments detailing the construction of high density, single molecule, ordered restriction maps from plasmids and from cDNA molecules, using two different enzymes, a result not previously reported. We discuss these results in the context of our calculations

  17. Early Loaded Single Implant Reinforced Mandibular Overdenture

    K. Nischal

    2016-01-01

    Full Text Available Rehabilitating atrophied mandible with two-implant supported denture is a common treatment modality for implant retained removable overdenture in mandible. This paper aims to design a treatment modality where single implant reinforced overdenture is fabricated for a severely atrophied mandibular ridge with early loading protocol. Results of studies have shown that a single implant mandibular overdenture significantly increases the satisfaction and quality of life of patients with edentulism. Midline fracture of the prosthesis is the most common complication related to single implant and two-implant retained mandibular overdentures. To manage such complication, a thin metal mesh is used to reinforce the overdenture and also to make the prostheses lighter and cost effective as compared to conventional cast metal framework.

  18. Stretching single fibrin fibers hampers their lysis.

    Li, Wei; Lucioni, Tomas; Li, Rongzhong; Bonin, Keith; Cho, Samuel S; Guthold, Martin

    2017-09-15

    Blood clots, whose main structural component is a mesh of microscopic fibrin fibers, experience mechanical strain from blood flow, clot retraction and interactions with platelets and other cells. We developed a transparent, striated and highly stretchable substrate made from fugitive glue (a styrenic block copolymer) to investigate how mechanical strain affects lysis of single, suspended fibrin fibers. In this suspended fiber assay, lysis manifested itself by fiber elongation, thickening (disassembly), fraying and collapse. Stretching single fibrin fibers significantly hampered their lysis. This effect was seen in uncrosslinked and crosslinked fibers. Crosslinking (without stretching) also hampered single fiber lysis. Our data suggest that strain is a novel mechanosensitive factor that regulates blood clot dissolution (fibrinolysis) at the single fiber level. At the molecular level of single fibrin molecules, strain may distort, or hinder access to, plasmin cleavage sites and thereby hamper lysis. Fibrin fibers are the major structural component of a blood clot. We developed a highly stretchable substrate made from fugitive glue and a suspended fibrin fiber lysis assay to investigate the effect of stretching on single fibrin fibers lysis. The key findings from our experiments are: 1) Fibers thicken and elongate upon lysis; 2) stretching strongly reduces lysis; 3) this effect is more pronounced for uncrosslinked fibers; and 4) stretching fibers has a similar effect on reducing lysis as crosslinking fibers. At the molecular level, strain may distort plasmin cleavage sites, or restrict access to those sites. Our results suggest that strain may be a novel mechanobiological factor that regulates fibrinolysis. Copyright © 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

  19. Laparoendoscopic single site in pelvic surgery

    Sanchez-Salas, Rafael; Clavijo, Rafael; Barret, Eric; Sotelo, Rene

    2012-01-01

    Laparoendoscopic single site (LESS) has recently gained momentum as feasible techniques for minimal access surgery. Our aim is to describe the current status of laparoendoscopic single site (LESS) in pelvic surgery. A comprehensive revision of the literature in LESS pelvic surgery was performed. References for this manuscript were obtained by performing a review of the available literature in PubMed from 01-01-01 to 30-11-11. References outside the search period were obtained selected manuscript΄s bibliography. Search terms included: pelvic anatomy, less in gynecology, single port colectomy, urological less, single port, single site, NOTES, LESS and single incision. 314 manuscripts were initially identified. Out of these, 46 manuscripts were selected based in their pelvic anatomy or surgical content; including experimental experience, clinical series and literature reviews. LESS drastically limit the surgeon's ability to perform in the operative field and the latter becomes hardened by the lack of space in anatomical location like the pelvis. Potential advantages of LESS are gained with the understanding that the surgical procedure is more technically challenging. Pelvic surgical procedures related to colorectal surgery, gynecology and urology have been performed with LESS technique and information available is mostly represented by case reports and short case series. Comparative series remain few. LESS pelvic surgery remain in its very beginning and due to the very specific anatomical conditions further development of LESS surgery in the mentioned area can be clearly be facilitated by using robotic technology. Standardization ad reproducibility of techniques are mandatory to further develop LESS in the surgical arena.. PMID:22557719

  20. Laparoendoscopic single site in pelvic surgery

    Rafael Sanchez-Salas

    2012-01-01

    Full Text Available Laparoendoscopic single site (LESS has recently gained momentum as feasible techniques for minimal access surgery. Our aim is to describe the current status of laparoendoscopic single site (LESS in pelvic surgery. A comprehensive revision of the literature in LESS pelvic surgery was performed. References for this manuscript were obtained by performing a review of the available literature in PubMed from 01-01-01 to 30-11-11. References outside the search period were obtained selected manuscript΄s bibliography. Search terms included: pelvic anatomy, less in gynecology, single port colectomy, urological less, single port, single site, NOTES, LESS and single incision. 314 manuscripts were initially identified. Out of these, 46 manuscripts were selected based in their pelvic anatomy or surgical content; including experimental experience, clinical series and literature reviews. LESS drastically limit the surgeon′s ability to perform in the operative field and the latter becomes hardened by the lack of space in anatomical location like the pelvis. Potential advantages of LESS are gained with the understanding that the surgical procedure is more technically challenging. Pelvic surgical procedures related to colorectal surgery, gynecology and urology have been performed with LESS technique and information available is mostly represented by case reports and short case series. Comparative series remain few. LESS pelvic surgery remain in its very beginning and due to the very specific anatomical conditions further development of LESS surgery in the mentioned area can be clearly be facilitated by using robotic technology. Standardization ad reproducibility of techniques are mandatory to further develop LESS in the surgical arena..