WorldWideScience

Sample records for simple kantor triple

  1. Hermitian (ϵ,δ-Freudenthal-Kantor Triple Systems and Certain Applications of *-Generalized Jordan Triple Systems to Field Theory

    Directory of Open Access Journals (Sweden)

    Noriaki Kamiya

    2014-01-01

    Full Text Available We define Hermitian (ϵ,δ-Freudenthal-Kantor triple systems and prove a structure theorem. We also give some examples of triple systems that are generalizations of the u(N⊕u(M and sp(2N⊕u(1 Hermitian 3-algebras. We apply a *-generalized Jordan triple system to a field theory and obtain a Chern-Simons gauge theory. We find that the novel Higgs mechanism works, where the Chern-Simons gauge theory reduces to a Yang-Mills theory in a certain limit.

  2. Sketch of J. R. Kantor's Psychological Interbehavioral Field Theory

    Science.gov (United States)

    Delprato, Dennis J.; Smith, Noel W.

    2009-01-01

    We provide a sketch of J. R. Kantor's (1959, 1971) psychological interbehavioral field (IBF) theory by identifying 9 essential points and briefly discussing each. The main emphasis of this sketch is on the foundation of Kantor's thinking, the IBF. Suggestions for further study are provided.

  3. PENGARUH DISIPLIN KERJA, KOMPETENSI PEGAWAI, DAN FASILITAS KANTOR TERHADAP KUALITAS PELAYANAN SUB BAGIAN TATA PEMERINTAHAN PADA PEMBUATAN KARTU KELUARGA (KK) DI KANTOR KECAMATAN MIRIT KABUPATEN KEBUMEN

    National Research Council Canada - National Science Library

    Nartika Puspita Febriarti; Hengky Pramusinto

    2015-01-01

    Tujuan penelitian ini adalah untuk mengetahui pengaruh disiplin kerja, kompetensi pegawai, dan fasilitas kantor terhadap kualitas pelayanan sub bagian tata pemerintahan pada pembuatan kartu keluarga (KK...

  4. PERANCANGAN STRATEGI PELAYANAN BERBASIS PENGETAHUAN PADA KANTOR NOTARIS

    Directory of Open Access Journals (Sweden)

    Sukarti Sukarti

    2016-10-01

    Key words      : Knowledge Management, Knowledge Sharing, Knowledge Management Roadmap Penelitian menghasilkan rancangan strategi untuk pelayanan pembuatan akta pada kantor Notaris, study kasus pada kantor Notaris Theresia Dwi Wijayanti, SH. Mekanisme dan alur kerja/prinsip pelayanan pembuatan akta masih berupa instruksi kerja, yang dipahami oleh beberapa pegawai saja, dan sering menjadi pertanyaan berulang pada bagian pelayanan serta menjadi kendala pada saat pegawai izin tidak masuk kerja. Karena mekanisme dan alur kerja/prinsip pelayanan belum jelas dan belum adanya media untuk pelayanan pembuatan akta otentik, mekanisme dan alur kerja/prinsip pelayanan dalam pembuatan akta pada kantor Notaris. Rancangan strategi ini difasilitasi dengan aplikasi pelayanan pembuatan akta yang dapat digunakan sebagai media dalam berbagi pengetahuan, menjadi portal Knowledge Manajement pada bagian pelayanan, sehingga menumbuhkan budaya penyebaran pengetahuan (Knowledge Sharing diantara pegawai dan pelayanan optimal kepada klien.  Metode pengembangan sistem yang digunakan adalah Knowledge Management Roadmap dengan tahapan pemodelan bisnis, pemodelan use case, analisis, perancangan, dan implementasi. Dengan metode Knowledge Manajement Roadmap menghasilkan rancangan strategi untuk bagian pelayanan pembuatan akta dan kantor Notaris memiliki sebuah media berbagi pengetahuan. Kata kunci: Manajemen Pengetahuan, Knowledge Sharing, Knowledge Manajement Roadmap.

  5. Tadeusz Kantor jõudis Kumusse enneolematus suuruses / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2011-01-01

    Näitus "Tadeusz Kantor. Poola avangardist ja teatriuuendaja" Kumu Kunstimuuseumis 18. detsembrini 2011. T. Kantori eluloost, mõjust Eestile. Näituse haridusprogramm. T. Kantori teatrireform puudutas peamiselt lavastuse visuaalset külge, kujundust. Kantori muuseumi direktori Natalia Zarzecka kommentaarid

  6. Kajian dan Pelaksanaan Manajemen Insiden di Kantor Pelayanan Perbendaharaan Negara di Lingkungan Kantor Wilayah Perbendaharaan Jawa Timur

    Directory of Open Access Journals (Sweden)

    Eko Supristiowadi

    2012-09-01

    Full Text Available Kantor Pelayanan Perbendaharaan Negara (KPPN adalah kantor perwakilan Departemen Keuangan di daerah yang berada di bawah Direktorat Jenderal Perbendaharaan, yang fungsi utamanya adalah pengelolaan Anggaran Pendapatan dan Belanja Negara (APBN khususnya dalam hal pengeluaran dana APBN. Untuk menunjang kegiatan operasional KPPN terkait pencairan dana APBN, KPPN menggunakan perangkat teknologi informasi baik yang bersifat perangkat keras maupun aplikasi. Semakin tinggi peranan teknologi informasi dalam menunjang kegiatan operasional KPPN, sudah seharusnya KPPN memiliki sebuah perangkat Manajemen Layanan Teknologi Informasi (MLTI yang dapat menjaga kualitas layanan teknologi informasi yang ada di KPPN. Penerapan MLTI bisa didasarkan pada sebuah standart yang sudah berlaku internasional seperti salah satunya adalah ITIL (Information Technology Infrastructur Library. Sebagai langkah awal pelaksanaan MLTI di KPPN, maka KPPN dapat melaksanakan manajemen insiden. Dengan adanya manajemen insiden diharapkan insiden yang terjadi pada perangkat layanan teknologi informasi di KPPN dapat tertangani secara cepat dan tidak sampai menganggu proses bisnis yang ada.

  7. Olemuse teater. Kantor ja Brook / Jan Kott ; tõlk. Eva-Liisa Linder

    Index Scriptorium Estoniae

    Kott, Jan

    2004-01-01

    T. Kantori lavastustest "Surnud klass" ja "Wielopole Wielopole" ning P. Brooki "Carmeni" lavastusest. Tõlgitud raamatust : Jan Kott. The Theatre of Essence: Kantor and Brook.- The Theatre of Essence and other Essays. Evanston, Northwestern University Press, 1984, lk. 159-165

  8. Analisis Pengaruh Human Capital Terhadap Kinerja Perusahaan (Studi Empiris pada Kantor Akuntan Publik di Indonesia

    Directory of Open Access Journals (Sweden)

    Martina Dwi Puji Astri Ongkorahardjo

    2008-01-01

    Full Text Available Human capital is of the intellectual capital components owned by a company. This study evaluates if individual capability and organizational climate affect business performance partially and simultaneously. We use public accounting firms as our subjects.. Our study shows that individual capability and organizational climate respectively influence performance in public accounting firms. Additionally, these two factors simultaneously affect performance. Overall individual capability shows stronger relationship to performance compared to organizational climate. Abstract in Bahasa Indonesia: Human capital sebagai salah satu komponen utama dari intellectual capital (intangible asset yang dimiliki oleh perusahaan. Penelitian ini menggunakan obyek kantor akuntan publik Penelitian ini berusaha menguji apakah individual capability dan the organizational climate yang merupakan komponen dari human capital memiliki pengaruh yang signifikan terhadap kinerja perusahaan kantor akuntan publik baik secara individual (parsial maupun secara simultan. Hasil penelitian menunjukkan bahwa pertama, individual capability berpengaruh signifikan terhadap kinerja kantor akuntan publik. Kedua, the organizational climate berpengaruh signifikan terhadap kinerja kantor akuntan publik. Ketiga, individual capability dan the organizational climate berpengaruh signifikan secara bersama-sama terhadap kinerja kantor akuntan publik. Pengujian juga membuktikan bahwa individual capability adalah variabel yang mempunyai pengaruh paling besar terhadap kinerja kantor akuntan publik. Kata kunci: Human capital, individual capability, the organizational climate.

  9. Pengembangan Sistem Informasi Pengelolaan Alat Tulis Kantor Pada Politeknik Harapan Bersama Tegal Berbasis Framework Yii

    Directory of Open Access Journals (Sweden)

    Muhamad Bakhar

    2017-07-01

    Full Text Available Kegiatan dalam pergururuan tinggi khususnya di Politeknik Harapan Bersama baik dalam administrasi maupun kegiatan belajar mengajar sangatlah identik dengan penggunaan alat tulis kantor atau yang biasa disebut dengan ATK. Dalam menyajikan laporan Persediaan Alat Tulis Kantor di UPT Logistik  yang masih menggunakan aplikasi perkantoran belum dapat menghasilkan seluruh laporan secara optimal, sehingga didalam menghasilkan seluruh laporan yang akurat dan tepat menjadi relatif lama, dengan adanya sistem informasi pengelolaan ATK berbasis web, maka laporan stok ATK dapat di pantau dengan mudah dan tepat juga dapat dicetak setiap saat sehingga efektif, efisien dalam mengambil keputusan untuk keperluan pengadaan

  10. AKTIVITAS PENGENDALIAN MUTU JASA AUDIT LAPORAN KEUANGAN HISTORIS (Studi Kasus pada Beberapa Kantor Akuntan Publik di Surabaya

    Directory of Open Access Journals (Sweden)

    Yulius Jogi Christiawan

    2005-01-01

    Full Text Available The objective of this study was to get the descriptive in depth and holistic the quality control activities in several CPAs%2C in Surabaya in order to answer the audit quality questioned by the audit report user. This study was a qualitative research with multiple case studies and multiple unit analysis approach. The study was focused on the competence and independence standards as well as the control procedures and its activities by partners and managers in CPA firms. There were%3A 1%29 the CPA firms face difficult in establishing independence in fact standards and objectives%2C 2%29 the CPA firms applied the professional standard to establish independence in appearance standards and objectives%2C 3%29 the CPA firms applied human resources management function to secure personnel educational competence%2C 4%29 the CPA firms applied planning%2C supervising and performance evaluating in order to obtain experience personnel%2C and 5%29 the CPA firms give strict punishment for violation of independence and competence. Abstract in Bahasa Indonesia : Penelitian ini bertujuan mengetahui secara mendalam %28in depth%29 dan menyeluruh tentang aktivitas pengendalian mutu audit yang terjadi di beberapa Kantor Akuntan Publik di Surabaya%2C sehingga diharapkan bisa menjawab keraguan pengguna jasa audit terhadap mutu audit yang ada di kantor akuntan publik. Penelitian ini adalah penelitian kualitatif dengan menggunakan pendekatan multiple case study dengan multiple unit analysis. Penelitian diarahkan pada standar independensi dan kompetensi di Kantor Akuntan Publik serta aktivitas dan prosedur pengendalian oleh partner dan manajer Kantor Akuntan Publik. Penelitian dilakukan terhadap empat dari lima puluh satu Kantor Akuntan Publik di Surabaya. Hasil penelitian ini sedikitnya menunjukkan lima fenomena terkait dengan aktivitas pengendalian mutu Kantor Akuntan Publik. Lima fenomena tersebut adalah%3A 1%29 Kantor Akuntan Publik sulit menetapkan suatu standar%2

  11. Mineral and Rock Physics Focus Group Selects Kantor for 2008 Graduate Research Award

    Science.gov (United States)

    McCammon, Catherine

    2009-03-01

    The Mineral and Rock Physics focus group has selected Innokenty Kantor as the recipient of the 2008 Graduate Research Award. Kantor pursued his Ph.D. in high-pressure mineral physics at the Bayerisches Geoinstitut, University of Bayreuth, Germany, under the supervision of Leonid Dubrovinsky and Catherine McCammon, and he successfully defended his thesis, entitled “High-pressure and high-temperature structural and electronic properties of (Mg, Fe)O and FeO,” in July 2007. Kantor came to Germany with a strong theoretical background after gaining a master's diploma with honors at Moscow State University, Russia. At the University of Bayreuth, he developed experimental experience by mastering the challenging techniques of diamond anvil cell experimentation, Mössbauer spectroscopy, X-ray and neutron diffraction, and X-ray absorption spectroscopy. Highlights of Kantor's thesis research include the discovery that the rhombohedral distortion in iron oxide (FeO) and magnesium iron oxide ((Mg, Fe)O) does not coincide with the magnetic ordering transition (contrary to what had been assumed for many years); a full description of spin crossover in (Mg, Fe)O above 50 gigapascals including the effect of short-range order; and a new high-pressure monoclinic modification of FeO that may change the interpretation of the B1 → B8 (rock salt to nickel arsenide structure) transition at high pressure and temperature. All of these results have had a significant impact on the research field and influenced models for the behavior of FeO and (Mg, Fe)O at high pressure. Kantor's achievements have been recognized by a number of other awards, most recently the E.ON Bayern Kulturpreis, awarded for one of the best doctoral theses in Bavaria across all research fields.

  12. PENGARUH DENDA, KESADARAN WAJIB PAJAK, DAN KUALITAS PELAYANAN FISKUS TERHADAP KEPATUHAN WAJIB PAJAK BADAN PADA KANTOR PELAYANAN PAJAK PRATAMA MAKASSAR SELATAN

    OpenAIRE

    -, MUSNIATI

    2014-01-01

    2014 Pengaruh Denda, Kesadaran Wajib Pajak, dan Kualitas Pelayanan Fiskus terhadap Kepatuhan Wajib Pajak Badan pada Kantor Pelayanan Pajak Pratama Makassar Selatan Effect Penalties, Taxpayer Awareness, andQuality of Service Tax Authoritieagainst Corporate Taxpayer Compliance In Kantor Pelayanan Pajak Pratama Makassar Selatan Musniati Amiruddin Kastumuni Harto Penelitian ini bertujuan untuk menganalisis pengaruh denda, kesadaran waj...

  13. ANALISIS KINERJA PEGAWAI PADA KANTOR PERTANAHAN KOTA PEKANBARU (PADA SEKSI HAK TANAH DAN PENDAFTARAN TANAH

    Directory of Open Access Journals (Sweden)

    Masirun Masirun

    2016-03-01

    Full Text Available Abstrak : Penelitian ini dilakukan di Kantor pertanahan kota pekanbaru riau, yang terletak dijalan, Pepaya NO 47 Kantor pertanahan merupakan kantor pelayanan masyarakat bertujuan membuat sertifikat-sertifikat tanah dan Tujuan penelitian ini adalah untuk menganalisis kinerja karyawan pada kantor pertanahan kota pekanbaru. Populasi dalam penelitian ini adalah seluruh karyawan pada kantor pertanahan Pekanbaru. Teknik sampling yang digunakan adalah sampling jenuh (sensus dimana seluruh anggota populasi dijadikan sampel penelitian, diperoleh jumlah sampel sebanyak 62 karyawan. Data yang diperoleh kemudian dianalisis secara deskriptif.Dalam penelitian ini, jenis dan sumber data yang digunakan berupa data primer yang diperoleh dari kantor pertanahan kota pekanbaru.diolah lebih lanjut, serta data sekunder yang berupa data yang telah jadi tanpa mengalami perubahan seperti sejarah singkat perusahaan, job description masing-masing bagian perusahaan, serta struktur organisasi perusahaan.Adapun pendidikan dan pelatihan pada kantor pertanahan kota pekanbaru riau jugak di katagorikan cukup baik. Hal ini dapat dilihat dari kualitas, produktivitas yang meningkat dengan adanya pendidikan dan pelatihan serta pengembangan idividu dan jugak dengan adanya pendidikan dan pelatihan tersebut sangat membantu dalam hal meningkatkan kualitas dan produktivitas kerja serta merupakan perencanaan dalam menciptakan sumber daya manusia yang lebih baik lagi.Dari hasil analisis penelitian tersebut diketahui bahwa rata-rata karyawan yang bekerja pada kantor pertanahan kota pekanbaru cukup baik, Kinerja karyawan tersebut dipengaruhi oleh beberapa faktor yaitu : Sifat, Perilaku, Kompetensi. Abstract : This study was conducted in the Office of Riau pekanbaru city land, which is located in the street, Papaya NO 47. The land office is aimed at making the civil service of the certificates of land and the purpose of this study is to analyze the performance of employees at the land office

  14. Tingkat Pemanfaatan Warung Masyarakat Informasi (Studi di Kantor Pos Makassar II

    Directory of Open Access Journals (Sweden)

    Paraden Lucas Sidauruk

    2011-06-01

    Full Text Available Masalah pokok penelitian ini adalah seberapa tinggi tingkat pemanfaatan Warmasif di Kantor Pos Makassar II. Subjek penelitian adalah individu yang menggunakan internet di Warmasif. Metode penelitian bersifat deskriptif dengan pendekatan kuantitatif dan survei. Teknik pengumpulan data menggunakan kuesioner yang dilengkapi wawancara mendalam dan observasi tidak terlibat. Hasil penelitian menunjukkan bahwa Warmasif dimanfaatkan sebagai tempat layanan mengakses internet seperti warnet. Tujuan utama responden ke Warmasif untuk berkomunikasi melalui jejaring sosial (Facebook, Twitter. Sedangkan, jenis informasi yang paling banyak dicari bukan informasi UKM, kesehatan, perpustakaan, melainkan informasi lainnya di luar ketiga jenis informasi itu (66,6%.Berdasarkan perhitungan persentase, tingkat pemanfaatan Warmasif setinggi 56,32 %. Untuk meningkatkannya, Kementerian Komunikasi dan Informatika diharapkan segera memperpanjang domain situs Warmasif www.warmasif.co.id. dan memperbaharui perangkat komputer-internet. Kantor Pos dan Dinas Komunikasi dan Informatika Makassar agar melakukan sosialisasi Warmasif kepada stakeholder dan masyarakat.

  15. PENGARUH DISIPLIN KERJA, KOMPETENSI PEGAWAI, DAN FASILITAS KANTOR TERHADAP KUALITAS PELAYANAN SUB BAGIAN TATA PEMERINTAHAN PADA PEMBUATAN KARTU KELUARGA (KK DI KANTOR KECAMATAN MIRIT KABUPATEN KEBUMEN

    Directory of Open Access Journals (Sweden)

    Nartika Puspita Febriarti

    2015-02-01

    Full Text Available Tujuan penelitian ini adalah untuk mengetahui pengaruh disiplin kerja, kompetensi pegawai, dan fasilitas kantor terhadap kualitas pelayanan sub bagian tata pemerintahan pada pembuatan kartu keluarga (KK di kantor kecamatan Mirit kabupaten Kebumen. Populasi dalam penelitian ini adalah kepala keluarga di kecamatan Mirit tahun 2014 berjumlah 11.737orang pegawai. Penelitian ini menggunakan sampel 100 pengunjung yang diperoleh dari rumus Slovin. Metode pengumpulan data menggunakan kuesioner, dokumentasi, wawancara dan observasi. Teknik analisis data menggunakan analisis deskriptif persentase, asumsi klasik, regresi berganda. Hasil penelitian menunjukkan bahwa analisis regresi berganda diperoleh persamaan: Y = 9.499 + 0.222X1 + 0.449X2 + 0.305X3. Uji F menunjukkan bahwa signifikansi 0,000. Secara parsial (Uji t variabel disiplin kerja diperoleh signifikansi 0,011, variabel kompetensi pegawai diperoleh signifikansi 0,000 dan variabel fasilitas kantor diperoleh signifikansi 0,022, sehingga H1, H2, H3, dan H4 dinyatakan diterima. Koefisien determinasi simultan (R2 antara disiplin kerja, kompetensi pegawai, dan fasilitas kantor terhadap kualitas pelayanan sebesar 0,577 atau 57,7%. The purpose of this research is to find out the influence of Work Discipline, Employee Competence and Office Facilities toward the Quality of Services Sub-Division on the Quality of Governance in Family Card (KK at Mirit Sub-district Office, Kebumen Regency. The population of this research were 11.737 head of family year 2014 in Mirit Sub-district. The samples were 100 visitors which based on formula Slovin. The data were collected by questionnaire and documentation, interview and observation . After that, the data were analyzed by percentage descriptive analysis, classical assumption, and doubled regression. The result of this study based on doubled linear regression analysis showed that the equation: Y = 9.499 + 0.222X1 + 0.449X2 + 0.305X3. The F-test showed that the

  16. PENINGKATAN HASIL BELAJAR MENGGUNAKAN PERALATAN KANTOR MELALUI MODEL PEMBELAJARAN KOOPERATIF TIPE NHT

    Directory of Open Access Journals (Sweden)

    Latifah Nurul Hidayah

    2013-02-01

    Full Text Available Berdasarkan hasil� observasi di SMK Negeri 1 Pemalang, diketahui bahwa mata diklat yang sulit bagi siswa adalah mata diklat Mengelola Peralatan Kantor. Kompetensi dasar dalam mata diklat tersebut yang masih dianggap sulit oleh siswa adalah Kompetensi dasar Menggunakan Peralatan Kantor. Salah satu faktor penyebab kesulitan siswa dalam belajar adalah kurang tepatnya model pembelajaran yang diterapkan oleh guru. Berdasarkan fakta di atas maka dilakukan upaya untuk meningkatkan hasil belajar siswa yaitu melalui penggunaan model pembelajaran NHT. Rancangan� penelitian yang dilakukan adalah penelitian tindakan kelas yang dilakukan dalam dua siklus. Hasil penelitian menunjukkan peningkatan hasil belajar. Siklus I menunjukan hasil penelitian yaitu rata-rata hasil belajar siswa 70,75 dengan ketuntasan klasikal 67,5% , keaktifan siswa 70,48%, kinerja guru 73,33%.� Penelitian siklus II menunjukan bahwa rata-rata hasil belajar siswa sebesar 79,13 dengan kriteria ketuntasan klasikal 85%, keaktifan siswa 79,52% dan kinerja guru 80,83%. Berdasarkan hasil penelitian disimpulkan bahwa pembelajaran Mata diklat Mengelola Peralatan Kantor kompetensi dasar Menggunakan Peralatan Kantor dengan model pembelajaran NHT dapat meningkatkan hasil belajar, sehingga disarankan kepada guru agar menggunakan model pembelajaran NHT dalam pembelajaran Mata diklat Mengelola Peralatan Kantor untuk meningkatkan hasil belajar siswa. Abstract ___________________________________________________________________ Based on the observation in SMK N 1 Pemalang, it shows that the difficult subject for the students is Managing Office Equipments. The most difficult basic competence in this subject for students is Using office Equipments. One of the factors which causes the students� difficulties is using the learning model inappropriately applied by the teacher. In line with the problem above, it needs an effort to improve the students� achievement such as using NHT learning model

  17. To prevent forgetfulness: from photography to the death theater of Tadeusz Kantor Para salvar do esquecimento: da fotografia ao teatro da morte de Tadeusz Kantor

    Directory of Open Access Journals (Sweden)

    Maria Irene Pellegrino de Oliveira Souza

    2006-12-01

    Full Text Available Photography is credited as a means to capture moments and to caress memory: in its essence, it is a fragment of reality embalmed in time. On the other hand, photographic reality seen as reality of the death, caresses life by remembering it of its losses. In this article, photography is thought of – in its time-space clips – as an object of rupture with daily reality. The aim is also to present the “death theater” of Polish stage director Tadeusz Kantor and reflect on the nature of this theater and photographic language. A fotografia é acreditada como meio de registrar momentos para acariciar a memória; é em sua essência um fragmento da realidade embalsamado no tempo. No entanto a realidade fotográfica, entendida como realidade da morte, acaricia a vida lembrando-a de suas perdas. No decorrer desse artigo pretende-se pensar a fotografia – por seu corte espaço-temporal – como um objeto de ruptura com a realidade cotidiana. Propõe-se também a apresentar o “teatro da morte” do encenador polonês Tadeusz Kantor refletindo sobre a natureza desse teatro e a linguagem fotográfica.

  18. ANALISIS BUDAYA ORGANISASI PEGAWAI DI KANTOR CAMAT RUMBAI PESISIR KOTA PEKANBARU

    Directory of Open Access Journals (Sweden)

    Prihati Prihati

    2016-09-01

    Full Text Available Abstrak Permasalahan yang timbul adalah sejak pemindahan kantor kurangnya inovasi yang dilakukan aparatur kecamatan dalam mengelola sarana dan prasarana, seperti belum melakukan renovasi/ tata ruang kantor baik internal maupun eksternal. Kemudian kurang stabilnya penyelenggaraan pemerintahan karena belum mengacu pada rencana tata ruang wilayah. Adapun tujuan yang ingin dicapai adalah untuk menganalisis bagaimana budaya organisasi di Kantor Camat Rumbai Pesisir Kota Pekanbaru dan menganalis hambatan budaya organisasi di Kantor Camat Rumbai Pesisir Kota Pekanbaru.Penelitian di lakukan di Kantor Kecamatan Rumbai Pesisir Kota Pekanbaru. Populasi dalam penelitian ini adalah aparatur kantor camat. Mereka dipilih karena terjangkau. Camat dijadikan sebagai Key Informan. Teknik penarikan sampel yang digunakan adalah sensus. Sumber dan jenis data dalam penelitian ini adalah primer dan sekunder. Untuk menghimpun data yang diperlukan, maka dipergunakan observasi, wawancara dan kuestioner. Data dianalisi secara deskriftip kualitatif.                 Dari kegiatan penelitian yang dilakukan diketahui budaya organisasi di Kantor Camat Rumbai Pesisir sudah berjalan dengan cukup baik. Karena secara umum, aparatur spilil negara (ASN di Kecamatan Rumbai Pesisir sudah memahmi pengertian budaya organisasi. Yakni, sebuah karakteristik yang dijunjung tinggi oleh organisasi dan menjadi panutan organisasi sebagai pembeda antara satu organisasi dengan organisasi yang lain atau budaya organisasi juga diartikan sebagai nilai-nilai dan norma perilaku yang diterima dan dipahami secara bersama oleh anggota organisasi sebagai dasar dalam aturan perilaku yang terdapat dalam organisasi tersebut.  Kata Kunci: Analisi, Budaya, Organisasi Abstract                     The problems arising from the transfer of the office is the lack of innovation that made the apparatus districts in managing facilities and infrastructure, such as has not been

  19. SISTEM PENGELOLAAN ARSIP DI KANTOR PERUM PERHUTANI DIVISI REGIONAL JAWA TENGAH

    Directory of Open Access Journals (Sweden)

    Aditya Yudha Primantoro

    2015-06-01

    Full Text Available Tujuan penelitian ini adalah untuk mengetahui sistem pengelolaan arsip di Kantor Perum Perhutani Divisi Regional Jawa Tengah, kendala-kendala yang dihadapi setra upaya-upaya untuk mengatasi kendala dalam sistem pengelolaan arsip. Penelitian ini menggunakan pendekatan kualitatif. Adapun subyek penelitian ini adalah petugas Sub.Bag. Umum dan petugas kearsipan di Kantor Perum Perhutani Divisi Regional Provinsi Jawa Tengah. Metode pengumpulan data dengan menggunakan hasil wawancara dan dokumentasi. Teknik analisis data menggunakan empat teknik yaitu pengumpulan data, reduksi data, penyajian data, simpulan verivikasi. Hasil penelitian menunjukkan sistem pengelolaan arsip di Kantor Perum Perhutani tahap pertama pengumpulan warkat, selanjutnya memeriksa tanda-tanda pelepasan oleh pimpinan, penetapan indeks, pemberian kode warkat, penyortiran, penyimpanan dan penataan warkat, pemeliharaan dan pengamanan arsip, penyusutan arsip, pemusnahan arsip. Kendala yang dihadapi pada saa tmemerikasa tanda-tanda pelepasan serta pendistribusian surat. Upaya yang dilakukan dengan mengirim surat kembali serta menyerahkan kepada pimpinan. The purpose of this study was to determine the records management system in the Office of Perum Perhutani Central Java Regional Division, constraints faced by Setra's efforts to overcome the obstacles in the archive management system. This study used a qualitative approach. The subject of this research is Sub.Bag officer. General and archival officer in the Office of the Regional Division Perhutanioffice Central Java Province. Data were collected by using interviews and documentation. Data were analyzed using four techniques of data collection, data reduction, data presentation, verification conclusions. The results show records management system in the first phase of the Office Perhutanioffice collection slips, then check for signs of release by the leadership, the determination of the index, script coding, sorting, storage and slips

  20. Tadeusz Kantor: La construcción del espacio escénico

    OpenAIRE

    Susmanscky Bacal, Silvia

    2014-01-01

    Si bien nuestra primera intención fue dedicar el presente estudio a los maniquíes de Tadeusz Kantor, durante la etapa de investigación el foco centrado en ese particular objeto -que el artista consideraba marginal- se fue ampliando en la medida en que, al inscribirlo en una perspectiva teórica como al resto de los elementos escénicos, los cuerpos artificiales aparecieron como otro signo, si bien peculiar, de un lenguaje escénico que vertebraba a todos los demás. ¿Por qué el artista hab...

  1. Hambatan Eksekusi Hak Tanggungan di Kantor Pelayanan Kekayaan Negara dan Lelang Yogyakarta

    Directory of Open Access Journals (Sweden)

    Imma Indra Dewi Windajani

    2012-02-01

    Full Text Available Many obstacles to execute mortgages by auctions on the Office of State Property and Auction Services (KPKNL Yogyakarta. The problem is how the constraints are solved by KPKNL Yogyakarta. This research finds two classifications of obstacles: legal and sociological.  Banyak hambatan yang dialami ketika ingin melaksanakan eksekusi hak tanggungan melalui lelang pada Kantor Pelayanan Kekayaan Negara Lelang (KPKNL Yogyakarta. Masalahnya adalah bagaimana hambatan tersebut diselesaikan oleh KPKNL Yogyakarta. Penelitian ini menghasilkan 2 klasifikasi hambatan, yaitu hambatan yuridis dan hambatan sosiologis.

  2. ANALISIS SWOT DALAM PENENTUAN STRATEGI PEMASARAN PRODUK PEMBIAYAAN PADA PT. PANIN BANK SYARIAH, TBK. KANTOR CABANG MALANG

    Directory of Open Access Journals (Sweden)

    Fani Firmansyah

    2014-07-01

    Full Text Available Tujuan dari penelitian ini PT Panin Bank Syariah, Tbk. (PBS perlu menetapkan strategi-strategi yang tepat agar kehadirannya dapat memperoleh respon positif dari masyarakat dan produk serta jasa yang ditawarkan sesuai dengan kebutuhan dan keinginan masyarakat. Penelitian ini akan dilakukan di PT. Panin Bank Syariah, Tbk. Kantor Cabang Malang yang terletak di Jl Mgr Sugiopranoto No 7 kota Malang Provinsi Jawa Timur. Jenis penelitian ini adalah penelitian kualitatif dengan pendekatan deskriptif. Dari hasil matriks SWOT dapat diambil beberapa strategi yang sesuai dengan keadaan PT Panin Bank Syariah, Tbk. Kantor Cabang Malang bedasarkan beberapa hal yaitu : Segmentasi, Targeting, Positioning, Marketing Mix. Berdasarkan penelitian yang telah dilakukan oleh peneliti, maka kesimpulan dari hasil penelitian ini yaitu: (a Strategi pemasaran khususnya pemasaran produk pembiayaan yangditerapkan oleh PT. Panin Bank Syariah, Tbk. Kantor Cabang Malang meliputi beberapa strategi, yakni strategi jemput bola, referal, membangun jaringan, memberikan servise excellent, dan memberikan fasilitas yang memuaskan untuk meningkatkan kepercayaan dan kepuasan nasabah, sehingga nasabah yang ada tidak akan lari dari bank. (b Hasil analisis SWOT menyebutkan bahwa PT. Panin Bank Syariah, Tbk. Kantor Cabang Malang sudah bisa bersaing di pasar persaingan yang kompetitif yang ada di wilayah Malang.  

  3. Da-Cruz Triple Tool: cómo hacer simple y precisa la cirugía de implante glúteo intramuscular

    Directory of Open Access Journals (Sweden)

    Luis Da-Cruz

    Full Text Available El Da-Cruz Triple Tool es un instrumento multifuncional diseñado para la colocación de implantes glúteos intramusculares. Tiene 3 funciones; a saber: disector, separador y medidor. Consiste en 2 piezas para su uso articulado o por separado. Como disector logra la profundidad y el grosor deseables del músculo glúteo mayor a través de maniobras precisas que provocan menos trauma; por consiguiente, ayuda a obtener una mejor recuperación y resultados. Al mismo tiempo faculta para elevar los espacios abiertos y controlar adherencias o sangrados. La función de medidor permite calcular la dimensión cefalocaudal y la anchura del espacio para escoger el implante adecuado. Con el entrenamiento adecuado en el uso de esta herramienta y la implementación de medidas pre, trans y postoperatorias bien definidas, cualquier cirujano plástico puede obtener resultados consistentemente exitosos en la colocación de implantes glúteos intramusculares.

  4. PENGARUH SUKU BUNGA DEPOSITO DAN LAYANAN ATM TERHADAP EKUITAS MEREK SERTA DAMPAKNYA TERHADAP KEPUTUSAN KONSUMEN UNTUK MENJADI NASABAH DI KANTOR CABANG UTAMA PT BANK JABAR DAN BANTEN TBK

    Directory of Open Access Journals (Sweden)

    Donni Juni Priansa

    2016-03-01

    deskriptif dan eksplanatori survei, dengan data utama diperoleh dari penyebaran kuesioner. Populasi penelitian ini adalah konsumen yang menjadi nasabah di Kantor Cabang Utama PT Bank Jabar dan Banten Tbk yang memanfaatkan layanan deposito dan ATM. Unit analisis dalam penelitian berjumlah 100 sampel yang diperoleh dengan menggunakan rumus Slovin, sedangkan teknik sampel yang digunakan adalah simple random sampling. Analisis data menggunakan analisis jalur dengan SPSS 20.00. Hasil penelitian menunjukkan bahwa suku bunga deposito dan layanan ATM berpengaruh positif dan signifikan terhadap ekuitas merek. Penelitian ini juga menemukan bahwa suku bunga deposito, layanan ATM, dan ekuitas merek berpengaruh positif dan signifikan terhadap keputusan konsumen untuk menjadi nasabah di Kantor Cabang Utama PT Bank Jabar dan Banten Tbk.   Kata Kunci: Suku Bunga Deposito, Layanan ATM, Ekuitas Merek, dan Keputusan Konsumen

  5. PENGELOLAAN ARSIP DALAM MENDUKUNG SISTEM INFORMASI MANAJEMEN (SIM DI KANTOR PERPUSTAKAAN DAN ARSIP KABUPATEN REMBANG

    Directory of Open Access Journals (Sweden)

    Sevi Martya Lungvy

    2014-06-01

    Full Text Available Tujuan dalam penelitian ini adalah untuk mengetahui pengelolaan arsip dalam mendukung system informasi manajemen (SIM di kantor Perpusakaan dan Arsip Kabupaten Rembang. Sumber data sebagai informan yaitu Kepala Kantor Perpustakaan dan Arsip Kabupaten Rembang, Kepala dan Staf Sub Bagian Tata Usaha, Kepala dan Seksi Arsip. Teknik pengumpulan data menggunakan teknik wawancara, observasi dan dokumentasi. Prosedur penelitian ini meliputi tahap pra-lapangan, tahap pekerjaan lapangan, dan tahap analisis data. Hasil penelitian yang diperoleh pada perencanaan arsip dengan mengidentifikasi kebutuhan arsip dan ruang khusus untuk menyimpan arsip. Pelaksanaan pengelolaan arsip diantaranya pelimpahan wewenang petugas arsip, pengalokasian anggaran, penyediaan peralatan dan perlengkapan, serta pengaplikasian sistem penyimpanan arsip. Pengendalian arsip untuk arsip yang mengalami kerusakan yang disebabkan oleh faktor eksternal, seperti terserang rayap dilakukan dengan cara memberi obat anti rayap dan dibersihkan secara rutin seminggu sekali serta menempatkan arsip pada rak dan lemari arsip yang terbuat dari bahan besi atau logam. Pengawasan arsip tidak hanya dilakukan oleh Kepala pada masing-masing bagian tetapi juga dilakukan oleh Kepala Kantor Perpustakaan dan Arsip Kabupaten Rembang di masing-masing bagian baik Sub Bagian Tata Usaha maupun bagian Seksi Kearsipan yang mengelola arsip. The purpose of this research is the record management in support of management information systems (MIS in the Library and Archieve Office in Rembang Regency. The sources data were from the Head of Library and Archieve Office in Rembang Regency, the Head and the staff of Administration Office, the Head and the staff of Archieve Office. The data were collected by interview, observation, and documentation, whereas; the procedures of the research were observation, in-depth interviews, and data analysis. The research showed that archival management needed a specific space for

  6. IMPLEMENTASI UJIAN ONLINE MENGGUNAKAN SIMUDIK PADA DDWK PAK KANTOR KEMENTERIAN AGAMA KOTA PEKALONGAN

    Directory of Open Access Journals (Sweden)

    RATNA PRILIANTI

    2017-09-01

    Full Text Available Tujuan dari penelitian ini yaitu untuk mendeskripsikan pelaksanaan ujian online menggunakan simudik pada pada DDWK (Diklat di Wilayah Kerja PAK (Penilaian Angka Kredit Kantor Kementerian Agama Kota Pekalongan. Manfaat dari penelitian ini adalah dapat memberikan informasi tentang pelaksanaan ujian online menggunakan simudik pada DDWK (Diklat di Wilayah Kerja PAK (Penilaian Angka Kredit Kantor Kementerian Agama Kota Pekalongan. Metode penelitian yang digunakan metode kualitatif yang  memiliki ciri khusus antara lain penekanan pada pengalaman langsung, proses, dan penafsiran peneliti. Penelitian dilakukan dengan diamati secara langsung untuk mendapatkan informasi pelaksanaan ujian online dan informasi tersebut dianalisis secara deskriptif. Hasil evaluasi pelaksanaan ujian online pada tahun  2015 dan 2016 menghasilkan suatu rekomendasi bahwa pada tahun 2017 untuk pretest dan posttest diklat di wilayah kerja (DDWK yang dilaksanakan di luar kampus Balai Diklat Keagamaan Semarang menggunakan simudik. Ada beberapa hal yang harus dipersiapkan terkait dengan pelaksanaan ujian simudik pada diklat DDWK. Hal-hal yang harus dipersiapakan dalam pelaksanaan ujian simudik adalah sumber daya manusia (widyaiswara, panitia dan peserta diklat, kelas DDWK PAK Kota Pekalongan pada simudik, soal ujian yang sudah diupload oleh pendamping (widyaiswara dan username serta password peserta diklat yang telah dimasukkan ke dalam kelas DDWK PAK Kota Pekalongan. Setelah kelas, soal ujian dan peserta DDWK PAK Kota Pekalongan sudah diinput dalam simdiklat oleh widyaiswara  adalah melakukan simulasi ujian online dan selanjutnya melaksanakan pretest di awal pembelajaran bagi para peserta diklat. Pelaksanaan ujian online diawali dengan tahap persiapan yaitu widyaiswara sebagai penanggungjawab mata kuliah membuat dan menyeting kelas, membuat dan mengupload soal ke simudik, memasukkan peserta diklat ke kelas,  membuatkan username dan password peserta diklat agar bisa masuk ke

  7. PENGELOLAAN ARSIP DINAMIS DALAM MENINGKATKAN SISTEM INFORMASI MANAJEMEN DI KANTOR PERPUSTAKAAN DAN ARSIP DAERAH KABUPATEN BANJARNEGARA

    Directory of Open Access Journals (Sweden)

    Sri Hastuti Pudji Rahayu

    2014-11-01

    Full Text Available Tujuan dari penelitian ini adalah mendeskripsikan fungsi-fungsi manajemen dalam arsip dinamis guna meningkatkan sistem informasi manajemen sehingga diperoleh kendala-kendala dan upaya-upaya yang dilakukan. Pendekatan dalam penelitian ini adalah pendekatan kualitatif dengan cara snowball sampling sebagai tekniknya. Metode penelitian yang digunakan peneliti adalah metode penelitian kepustakaan dan studi lapangan yang meliputi observasi, wawancara dan dokumentasi. Peneliti memilih metode analisis data menurut Miles dan Huberman yang meliputi tiga tahapan: reduksi data, display data, verifikasi. Hasil penelitian menunjukkan bahwa Kantor Perpustakaan dan Arsip Daerah Kabupaten Banjarnegara menggunakan pola klasifikasi dalam pelaksanaan pengelolaan arsip dinamis. Dengan penggunaan sistem itulah sistem informasi manajemen dapat dilaksanakan dengan baik. Kekurangan sistem ini adalah pada kegiatan pencatatan dan penyimpanan arsip dinamis aktif yang tidak dilaksanakan secara rutin dikarenakan pada bagian itu tidak ditunjuk petugas arsip yang menangani arsip, namun hanya dibebankan oleh seorang pegawai saja. Selain itu, sampai saat ini kantor juga belum melaksanakan pemusnahan arsip yang sudah tidak memiliki nilai guna. The purpose of this study is to describe the functions of records management in order to improve the management of information systems in order to obtain the constraints and the efforts undertaken. The approach in this study is a qualitative approach with purposive sampling and snowball sampling as a technique. The research method used is the method of literature research investigators and field studies that include observations, interviews and documentation. Researchers chose the method of data analysis that includes Miles and Huberman three phases: data reduction, data display, verification. The study procedures include the permitting process, the implementation in the field, until the The results showed that the Office of Library and

  8. Efektifitas sistem informasi berbasis online dalam pengurusan vaksin calon keberangkatan jemaah umrah di kantor kelas II pekanbaru

    Directory of Open Access Journals (Sweden)

    Bayu Febriadi

    2017-01-01

    Full Text Available AbstrakSeiring dengan perkembangan teknologi yang begitu pesat, sistem informasi berbasis komputer sangat berpengaruh pesat dalam dunia kerja, begitu juga halnya sistem informasi berbasis web dimanfaatkan sebagai sarana peningkatan informasi. Pemanfaatan tersebut akan mempermudah suatu pekerjaan seperti halnya pengolahan data lebih cepat, keputusan yang akan diambil lebih tepat, menghemat waktu dan biaya. Selain itu, sistem informasi yang berbasis web juga dapat menjadi sarana promosi yang efesien dan sumber informasi yang dapat diakses oleh pengguna internet yang semakin lama semakin luas. Pada kantor Kesehatan Pelabuhan Pekanbaru selalu dihadapi dengan kendala antri atau lama dalam pengurusan vaksin keberangkatan calon Jemaah umrah, karena dalam pengurusan vaksin pada kantor Kesehatan Pelabuhan pekanbaru belum adanya sistem terkomputerisasi, sehingga hal ini memperlambat kinerja kantor Kesehatan Pelabuhan pekanbaru, begitupun bagi calon Jemaah umrah yang selalu tidak puas dalam pelayanan vaksin untuk keberangkatan calon jemaah umrah karena terlalu lama dalam pemprosesan hasil dari analisa vaksin keberangkatan calon Jemaah umrah. Adapun metode yang digunakan dengan mengumpulkan data-data yang ada dan menganalisa permasalahan dalam pengurusan vaksin dengan membangun sebuah sistem berbasis web. Tujuan umum dari penelitian ini memberi suatu efisiensi atau peningkatan dalam pengolahan data yang berbasis web sehingga membantu kegiatan kantor Kesehatan Pelabuhan Pekanbaru, tujuan khususnya dimana calon jemaah umrah bisa melihat jadwal vaksin nya dan bisa melihat pengumuman yang lebih cepat dan tepat tanpa harus datang ke kantor Kesehatan Pelabuhan Pekanbaru, hanya dengan mengakses internet dan mengakses website Kantor Kesehatan Pelabuhan pekanbaru dengan mudah, tidak memerlukan waktu yang lama. Kata kunci: Vaksin, Web, Kesehatan Pelabuhan Pekanbaru. AbstractAlong with the development of technology so fast, computer-based information systems are very

  9. ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI TURNOVER INTENTIONS PADA STAF KANTOR AKUNTAN PUBLIK

    Directory of Open Access Journals (Sweden)

    Agus Arianto Toly

    2001-01-01

    Full Text Available The high level of turnover intentions by accountant staffs had raised the potential cost for public accountant firms. The prior research done by Suwandi and Indriantoro (1999 had succesfully identified the process of turnover intentions, which related to the antecedents and consequences of job insecurity. The responses of 30 accountant staffs from some public accountant firms to a questionnaire designed to measure variables were analyzed using a Pearson's correlation coefficient. The result of this study was not generally consistent with Suwandi and Indriantoro (1999 because some hypotheses were rejected. This study identified that public accountant firm must be noticed organizational factors, such as organizational commitment, role conflict, role ambiguity, and organizational change. Abstract in Bahasa Indonesia : Tingkat keinginan berpindah yang tinggi para staf akuntan telah menimbulkan biaya potensial untuk Kantor Akuntan Publik (KAP. Penelitian sebelumnya yang dilakukan oleh Suwandi dan Indriantoro (1999 telah berhasil mengidentifikasi proses keinginan berpindah, yang berhubungan dengan anteseden dan konsekuensi dari ketidakamanan kerja. Respon 30 staf akuntan dari beberapa KAP terhadap kuesioner yang dibuat untuk mengukur berbagai variabel, dianalisis menggunakan kofisien korelasi Pearson. Hasil dari studi ini secara umum tidak konsisten dengan Suwandi dan Indriantoro (1999 karena ditolaknya beberapa hipotesis. Studi ini mengidentifikasi bahwa KAP harus memberi perhatian terhadap beberapa faktor organisasional, seperti komitmen organisasional, konflik peran, ketidakjelasan peran, dan perubahan organisasional. Kata kunci: konflik peran; ketidakjelasan peran; perubahan organisasional; ketidakamanan kerja; komitmen organisasional; keinginan berpindah.

  10. Pembuatan Sistem Informasi Penatausahaan Surat dan Arsip Berbasis Web Studi Kasus Kantor Pelayanan Perbendaharaan Negara Bengkulu

    Directory of Open Access Journals (Sweden)

    Triyono Triyono

    2013-09-01

    Full Text Available Penatausahaan surat dan arsip merupakan kegiatan pendukung bagi pelaksanaan tugas pokok Kantor Pelayanan Perbendaharaan Negara (KPPN Bengkulu. Kegiatan ini ditangani oleh Sub Bagian Umum KPPN. Saat ini terdapat beberapa aplikasi penatausahaan surat maupun arsip yang dibuat oleh beberapa pegawai pada Direktorat Jenderal Perbendaharaan yang digunakan secara terpisah pada beberapa KPPN. Pada umumnya aplikasi ini tidak mengakomodasi proses yang melibatkan bagian-bagian di KPPN, dan belum digunakan sepenuhnya. KPPN bahkan lebih memilih penatausahaan dengan cara manual daripada dengan menggunakan aplikasi yang ada. Penatausahaan yang dilakukan dengan cara manual menyebabkan inefisiensi, redundansi data, kesulitan dalam proses pencarian surat dan pengawasan proses penatausahaan surat kurang dapat dilakukan. Sistem informasi penatausahaan surat dan arsip pada KPPN Bengkulu akan dikembangkan untuk meningkatkan kualitas proses dengan bahasa pemrograman inti PHP dan MySQL sebagai pendukung sistem manajemen basis data. Aplikasi ini akan mengakomodasi proses-proses yang melibatkan unit eselon IV pada KPPN, monitoring penyelesaian surat dan penyimpanan arsip elektronik baik surat masuk maupun surat keluar. Sistem informasi ini dikembangkan melalui proses ICONIX. Hasil dari penelitian ini merupakan aplikasi yang berguna untuk penatausahaan surat dan arsip bagi KPPN Bengkulu.

  11. Perancangan Kantor Digital Berbasis Framework dengan Metode Waterfall pada Politeknik Negeri Lampung

    Directory of Open Access Journals (Sweden)

    Tri Sandhika Jaya

    2017-07-01

    Full Text Available MVC dikembangkan untuk memetakan input, process, output. Web framework sangat cocok untuk pengembangan aplikasi berbasis web karena lebih fleksibel dan secure. Proses  bisnis  di  perguruan  tinggi  tidak akan lepas dari berbagai permasalahan, seperti manajemen projek yang kurang rapi, atau proses manajemen  lainnya,  informasi  yang  kurang  akurat dan responsi naskah atau dokumen menggunakan kertas,   apabila   dilakukan   berulang   maka   dapat memicu  pengeluaran  dana  yang  tidak  sedikit, pencarian   dokumen   hardcopy   dimasa   yang   akan datang juga sulit dilakukan karena tidak ada tempat penyimpanan  secara  elektronik.  Maka  untuk mengatasi permasalahan tersebut maka peneliti mengembangkan Kantor Digital berbasis framework dengan Metode Waterfall.

  12. PENGARUH PELAKSANAAN KESELAMATAN DAN KESEHATAN KERJA, SARANA KANTOR DAN PENGALAMAN KERJA TERHADAP KINERJA PEGAWAI DINAS KESEHATAN PROVINSI JAWA TENGAH

    Directory of Open Access Journals (Sweden)

    Adjib Hamzah

    2015-02-01

    Full Text Available Tujuan penelitian ini adalah untuk mengetahui pengaruh pelaksanaan keselamatan dan kesehatan kerja, sarana kantor dan pengalaman kerja terhadap kinerja pegawai Dinas kesehatan Provinsi Jawa Tengah baik secara parsial maupun simultan. Populasi dalam penelitian ini adalah pegawai Dinas Kesehatan provinsi Jawa Tengah sebanyak 80 pegawai. Metode pengumpulan data yang digunakan adalah metode kuesioner, observasi, dokumentasi dan interview. Teknik analisis data menggunakan analisis regresi berganda dan analisis deskriptif persentase. Hasil analisis menunjukkan bahwa persamaan garis regresi linier berganda yaitu Y = 3,976 +0,092X1 +0,683X2 +0,295X3+e. Hasil perhitungan menunjukkan besarnya pengaruh secara parsial pelaksanaan keselamatan dan kesehatan kerja sebesar 10,7%, besarnya pengaruh sarana kantor sebesar 49,7%, dan besarnya pengaruh pengalaman kerja sebesar 7,8%. Sedangkan secara simultan pelaksanaan keselamatan dan kesehatan kerja, sarana kantor dan pengalaman kerja sebesar 66,7% The purpose of this research were to find out influence of the OHS implementation, office facilities and work experience towards employees’ performance in Departmen of Health Central Java either partially or simultaneously. The population in this research were 80 employees. The data were collected by questionnaires, observations, documentations and interviews. The data were analyzed by multiple linier regression and dercriptive percentage. The result showed that multiple linear regression analysis was Y = 3.976 +0.092X1 +0.683X2 +0.295X3+e. The calculation showed that the partial influence OHS implementation was 10,7%, the partial influence of office facilities was 49.7% and the partial influence of work experience was 7.8%. Whereas, the simultaneous influence of implementation of occupational health and safety, office facilities and work experience was 66,7%.

  13. PENGELOLAAN ARSIP DINAMIS PADA KANTOR PERPUSTAKAAN UMUM DAN ARSIP DAERAH KOTA SEMARANG

    Directory of Open Access Journals (Sweden)

    Maksurotul Laili

    2014-11-01

    Full Text Available Tujuan Penelitian ini adalah untuk mengetahui bagaimana pengelolaan arsip dinamis, kendala apa saja yang dihadapi dalam pelaksanaan pengelolaan arsip dinamis, dan bagaimana usaha dalam mengatasi kendala yang dihadapi dalam pelaksanaan pengelolaan arsip dinamis pada Kantor Perpustakaan Umum dan Arsip Daerah Kota Semarang. Penelitian ini menggunakan metode kualitatif. Sumber data dalam penelitian ini sebagai informan yaitu Pengelola Arsip, Kepala TU, dan Arsiparis Bagian Arsip Daerah. Teknik pengumpulan data dalam penelitian ini menggunakan teknik observasi, wawancara, dan dokumentasi. Teknik analisisi data meliputi pengumpulan data, reduksi data, penyajian data, dan menarik kesimpulan. Hasil penelitian meliputi, penciptaan arsip berupa penerimaan dan pembuatan arsip. Penggunaan arsip meliputi kegiatan pelayanan peminjaman dan temu kembali. Peminjaman arsip belum menggunakan kartu pinjam arsip. Pemeliharaan meliputi pemberkasan, penataan, penyimpanan, dan alih media. Penyusutan meliputi kegiatan pemindahan dan pemusnahan arsip. Penyusutan arsip belum melakukan jadwal retensi arsip. The purpose of this study was to determine how the management of records , any obstacles encountered in the implementation of records management , and how the effort to overcome the obstacles encountered in the implementation of records management in the Office of Archives and Public Library in Semarang. It was a qualitative research. The data sources – as the informant – were the Archive Manager, the Head of Administration, the Archivists of the Regional Archivessection. The data were collected by observation, interview, and documentation. The data analysis were performed by means of data collection, data reduction, data presentation and conclusion. Based on this research, it can be concluded that the creation of the archive consists of two forms; they are acceptance and archiving. The use of the archive includes lending and retrieval services, the archives lending

  14. Triple P Divers

    NARCIS (Netherlands)

    Drs. Mieke van Heerebeek; Cecile Winkelman; Marjolijn Distelbrink; Ouafila Essayah; Susan Ketner

    2011-01-01

    De Kenniswerkplaats Tienplus richt zich op de vraag hoe het bereik en de effectiviteit van de opvoedsteun aan ouders van diverse herkomst vergroot kan worden. Deze rapportage bericht over het project Triple P Divers. Triple P is een evidence based programma voor opvoedingsondersteuning dat in

  15. PENGARUH DISIPLIN KERJA, FASILITAS KERJA, TINGKAT PENDIDIKAN DAN KEPEMIMPINAN TERHADAP PENGELOLAAN KEARSIPAN DI KANTOR KECAMATAN WIRADESA KABUPATEN PEKALONGAN

    Directory of Open Access Journals (Sweden)

    Dewi Sukmawati

    2014-06-01

    Full Text Available Tujuan penelitian ini adalah untuk mengetahui pengaruh disiplin kerja, fasilitas kerja, tingkat pendidikan dan kepemimpinan terhadap pengelolaan kearsipan di kantor kecamatan Wiradesa Kabupaten Pekalongan baik secara parsial maupun simultan. Populasi dalam penelitian ini adalah pegawai kantor kecamatan Wiradesa sebanyak 57 pegawai. Metode pengumpulan data yang digunakan adalah metode kuesioner, observasi, dokumentasi dan interview. Teknik analisis data menggunakan analisis deskriptif dan analisis inferensial. Hasil analisis menunjukkan bahwa persamaan garis regresi linier berganda yaitu Y = 34.975 + 0.210X1 + 0.358X2 + 0.472X3 + 0.179X4 + e. Hasil perhitungan menunjukkan besarnya pengaruh secara parsial disiplin kerja sebesar 8.6%, besarnya pengaruh fasilitas kerja sebesar 8.9%, besarnya pengaruh tingkat pendidikan sebesar 10.6%, dan besarnya pengaruh kepemimpinan sebesar 8.7%. Sedangkan secara simultan disiplin kerja, fasilitas kerja, tingkat pendidikan dan kepemimpinan sebesar 79.2%.. The purpose of this research is to find out whether there is an influence of the work discipline, working facilities, level of education and leadership towards archives management system in District office Wiradesa, Pekalongan either partially or simultaneously. The population in this research are 57 employees of District office Petarukan. The data collecting method is questionnaire, observations, documentation and interviews. The analysis data technique are descriptive and inferential analysis. Result of the analysis shows the multiple linear regression equivalent is Y = 34.975 + 0.210X1 + 0.358X2 + 0.472X3 + 0.179X4 + e. The calculations show the influence partially, the influence of labor discipline by 8.6%, the influence of the working facilities of 8.9%, the magnitude of the effect of educational level of 10.16%, as well as the influence of leadership by 8.7%. While the simultaneous influence of labor discipline, working facilities, level of education, and

  16. Pengaruh Komunikasi, Kepemimpinan dan Motivasi Kerja Terhadap Kinerja Karyawan Studi Pada Kantor Wilayah XII Direktorat Jenderal Kekayaan Negara (DJKN Banjarmasin

    Directory of Open Access Journals (Sweden)

    Andi Susanto

    2016-04-01

    Full Text Available This research aims to fi nd out and analyze the infl uence among communication (X1, leadership (X2, and work motivation (X3 as indefendent variables either partially or simultaneously toward employee’s performance (Y as dependent variable at Kantor Wilayah XII DJKN Banjarmasin. The method of this research used questionnaire with 32 employees of Kantor Wilayah  XII  DJKN  Banjarmasin  as  a  sample  and  it  has  been  selected  from population  as  45  emplyees.  The  variables  measurement  uses  Likert’s  Scale technique with weighting scale from 1 to 5. To fi nd out the correlation among variables X1 X2 X3 towards Y uses statistical technique of correlation analysis,  multiple linear regression and to test the signifi cance rate uses F test and t test processed with SPSS Program. The  result  of  research  concludes  that  there  is  a  positive  signifi cant  infl uence from each indefendent variable’s toward the dependent variable. From the three indefendent  variables,  the  highest  percentage  (25.9%  is  the  communication (X1  as  compared  with  the  two  other  independent  variables.  And  there  is  a signifi cant  simultaneously  infl uence  from  the  three  independent  variables toward the variable of employee’s performance. Keyword :Communication, leadership, work motivation, performance.

  17. PENGARUH DISIPLIN KERJA, FASILITAS KERJA, TINGKAT PENDIDIKAN DAN KEPEMIMPINAN TERHADAP PENGELOLAAN KEARSIPAN DI KANTOR KECAMATAN WIRADESA KABUPATEN PEKALONGAN

    Directory of Open Access Journals (Sweden)

    Dewi Sukmawati

    2014-11-01

    Full Text Available Tujuan penelitian ini adalah untuk mengetahui pengaruh disiplin kerja, fasilitas kerja, tingkat pendidikan dan kepemimpinan terhadap pengelolaan kearsipan di kantor kecamatan Wiradesa Kabupaten Pekalongan baik secara parsial maupun simultan. Populasi dalam penelitian ini adalah pegawai kantor kecamatan Wiradesa sebanyak 57 pegawai. Metode pengumpulan data yang digunakan adalah metode kuesioner, observasi, dokumentasi dan interview. Teknik analisis data menggunakan analisis deskriptif dan analisis inferensial. Hasil analisis menunjukkan bahwa persamaan garis regresi linier berganda yaitu Y = 34.975 + 0.210X1 + 0.358X2 + 0.472X3 + 0.179X4 + e. Hasil perhitungan menunjukkan besarnya pengaruh secara parsial disiplin kerja sebesar 8.6%, besarnya pengaruh fasilitas kerja sebesar 8.9%, besarnya pengaruh tingkat pendidikan sebesar 10.6%, dan besarnya pengaruh kepemimpinan sebesar 8.7%. Sedangkan secara simultan disiplin kerja, fasilitas kerja, tingkat pendidikan dan kepemimpinan sebesar 79.2%. The purpose of this research is to find out whether there is an influence of the work discipline, working facilities, level of education and leadership towards archives management system in District office Wiradesa, Pekalongan either partially or simultaneously. The population in this research are 57 employees of District office Petarukan. The data collecting method is questionnaire, observations, documentation and interviews. The analysis data technique are descriptive and inferential analysis. Result of the analysis shows the multiple linear regression equivalent is Y = 34.975 + 0.210X1 + 0.358X2 + 0.472X3 + 0.179X4 + e. The calculations show the influence partially, the influence of labor discipline by 8.6%, the influence of the working facilities of 8.9%, the magnitude of the effect of educational level of 10.16%, as well as the influence of leadership by 8.7%. While the simultaneous influence of labor discipline, working facilities, level of education, and

  18. Simple Machines Made Simple.

    Science.gov (United States)

    St. Andre, Ralph E.

    Simple machines have become a lost point of study in elementary schools as teachers continue to have more material to cover. This manual provides hands-on, cooperative learning activities for grades three through eight concerning the six simple machines: wheel and axle, inclined plane, screw, pulley, wedge, and lever. Most activities can be…

  19. Triple Point Topological Metals

    Directory of Open Access Journals (Sweden)

    Ziming Zhu

    2016-07-01

    Full Text Available Topologically protected fermionic quasiparticles appear in metals, where band degeneracies occur at the Fermi level, dictated by the band structure topology. While in some metals these quasiparticles are direct analogues of elementary fermionic particles of the relativistic quantum field theory, other metals can have symmetries that give rise to quasiparticles, fundamentally different from those known in high-energy physics. Here, we report on a new type of topological quasiparticles—triple point fermions—realized in metals with symmorphic crystal structure, which host crossings of three bands in the vicinity of the Fermi level protected by point group symmetries. We find two topologically different types of triple point fermions, both distinct from any other topological quasiparticles reported to date. We provide examples of existing materials that host triple point fermions of both types and discuss a variety of physical phenomena associated with these quasiparticles, such as the occurrence of topological surface Fermi arcs, transport anomalies, and topological Lifshitz transitions.

  20. FAKTOR-FAKTOR YANG MEMENGARUHI TINGKAT KOLEKTIBILITAS PEMBIAYAAN SEKTOR UMKM (STUDI KASUS : BANK SYARIAH XYZ KANTOR CABANG JAKARTA BARAT

    Directory of Open Access Journals (Sweden)

    Raden Yogi Arieffiandi

    2016-09-01

    Full Text Available The objectives of this study are to analyze the factors that affect the financing collectability in XYZ Sharia Bank branch office in West Jakarta, to formulate and recommend a strategic planning of the bank to reduce the level of Non-Performing Loans (NPF in the future. Logistic regression and SWOT matrix were utilized as the methods of this study. Thus, the results showed that the factors influencing the financing collectability of XYZ Sharia Bank customers are financing agreement types, margin/profit sharing equivalent rate, economic sectors, and value of the company Altman Z-Score. From the analyses of both external and internal factors, it reveals that strategic factors are identified to reduce the value of NPF in XYZ Sharia Bank West Jakarta i.e. by performing defensive actions. The assessment results of the strategy in XYZ Islamic Bank, West Jakarta, in terms of SWOT in tightening the cost analysis of SME sector, are as follow: carrying out the process of cost analysis more carefully and thoroughly, and conducting HR personnel training, or sharing with other branches in the neighboring areas, anticipating over assessment by adopting an independent assessor, performing more detailed screening in doing financing disbursement, and maximizing the existing internal regulations related to the financing facility.Keywords: Collectable financing, logistic regression, SWOT, Altman Z-Score, SMEABSTRAKTujuan dari penelitian ini adalah menganalisis faktor-faktor yang berpengaruh terhadap kolektibilitas pembiayaan pada Bank Syariah XYZ kantor cabang Jakarta Barat dan merumuskan dan merekomendasikan perencanaan strategis Bank Syariah XYZ dalam rangka menekan tingkat Non Performing Loans (NPF di masa yang akan datang. Metode penelitian ini menggunakan regresi logistik dan matriks SWOT. Hasil dari penelitian ini diperoleh faktor-faktor yang memengaruhi kolektibilitas pembiayaan oleh nasabah Bank Syariah XYZ adalah Jenis akad pembiayaan, tingkat equivalent

  1. Overcoming Triple Segregation

    Science.gov (United States)

    Gandara, Patricia

    2010-01-01

    Latinos are, after whites, the most segregated student group in the United States, and their segregation is closely tied to poor academic outcomes. Latinos experience a triple segregation: by race/ethnicity, poverty, and language. Racial segregation perpetuates negative stereotypes, reduces the likelihood of a strong teaching staff, and is often…

  2. EVALUASI KINERJA SISTEM INFORMASI E-FILING MENGGUNAKAN COBIT 5 PADA KANTOR PELAYANAN PAJAK PRATAMA KOTA SALATIGA

    Directory of Open Access Journals (Sweden)

    Agustinus Fritz Wijaya

    2017-04-01

    Full Text Available Kantor Pelayanan Pajak (KPP Pratama merupakan salah satu instansi di bawah Kementerian Keuanngan. Tugas utama dari KPP Pratama yaitu melaksanakan penyuluhan, pelayanan, dan pengawasan terhadap Wajib Pajak khususnya dibidang Pajak Penghasilan, Pajak Penjualan, Pajak Pertambahan Nilai, serta pajak tidak langsung lainnya. Dalam pelaksanaan tugasnya KPP Pratama menerapkan sistem IT governance untuk pencapaian tujuan bisnis namun kurangnya tata kelola dalam penerapan sistem IT governance mengakibatkan kurang optimalnya KPP Pratama dalam menjalankan tugas dan pencapaian tujuan. Diperlukan penilaian tingkat kematangan IT governance untuk mengetahui pencapaian KPP Pratama dari tujuan bisnisnya, sehingga menghasilkan rekomendasi untuk memperbaiki tata kelola dalam penerapan IT Governance. Dalam menilai tingkat kematangannya digunakan pendekatan dengan COBIT 5. Dengan 15 responden dari 2 divisi menggunakan metode deskriptif kuantitatif dan kuesioner penelitian berfokus pada domain proses APO 13, BAI 06, dan DSS 05. Domain proses yang digunakan dalam penelitian didapat dari hasil pemetaan terhadap tujuan bisnis, tujuan TI, dan terkait proses TI. Hasilnya rata-rata tingkat kematangan  dari ketiga domain proses yaitu 1,22 dengan berada pada level 1 (Performed Process.

  3. Triple gauge boson couplings

    CERN Document Server

    Gounaris, George J; Zeppenfeld, Dieter; Ajaltouni, Ziad J; Arhrib, A; Bella, G; Berends, F A; Bilenky, S M; Blondel, A; Busenitz, J K; Choudhury, D; Clarke, P; Conboy, J E; Diehl, M; Fassouliotis, D; Frère, J M; Georgiopoulos, C H; Gibbs, M; Grünewald, M W; Hansen, J B; Hartmann, C; Jin, B N; Jousset, J; Kalinowski, Jan; Kocian, M L; Lahanas, Athanasios B; Layssac, J; Lieb, E H; Markou, C; Matteuzzi, C; Mättig, P; Moreno, J M; Moultaka, G; Nippe, A; Orloff, J; Papadopoulos, C G; Paschalis, J; Petridou, C; Phillips, H; Podlyski, F; Pohl, M; Renard, F M; Rossignol, J M; Rylko, R; Sekulin, R L; Van Sighem, A; Simopoulou, Errietta; Skillman, A; Spanos, V C; Tonazzo, A; Tytgat, M H G; Tzamarias, S; Verzegnassi, Claudio; Vlachos, N D; Zevgolatakos, E

    1996-01-01

    We present the results obtained by the "Triple Gauge Couplings" working group during the LEP2 Workshop (1994-1995). The report concentrates on the measurement of WW\\gamma and WWZ couplings in e^-e^+\\to W^-W^+ or, more generally, four-fermion production at LEP2. In addition the detection of new interactions in the bosonic sector via other production channels is discussed.

  4. Pengaruh Praktek Kepemimpinan, Pengembangan Pegawai dan Persepsi Peran terhadap Kinerja Penyidik PPNS Hak Kekayaan Intelektual Kantor Wilayah Departemen Hukum Dan Hak Asasi Manusia se-Sumatera

    Directory of Open Access Journals (Sweden)

    Agustiar Agustiar

    2009-08-01

    Full Text Available Penelitian ini bertujuan untuk mengetahui pengaruh faktor-faktor kepemimpinan, pengembangan pega¬wai dan persepsi peran terhadap kinerja Penyidik Pejabat Pegawai Negeri Sipil Hak Kekayaan Intelektual (PPNS HKI dan untuk mengetahui di antara faktor-faktor tersebut yang dominan berpengaruh terhadap kinerja Penyi¬dik PPNS HKI Kantor Wilayah Departemen Hukum dan HAM Provinsi Se-Sumatera.Populasi pada penelitian ini adalah seluruh PPNS HKI yang berada pada Provinsi Se-Sumatera seba¬nyak 33 orang, namun karena yang mengembalikan kuesioner hanya 30 orang, maka responden pada penelitian ini berjumlah 30 orang. Model analisis yang digunakan adalah regresi linear berganda. Hasil penelitian menunjukkan bahwa faktor kepemimpinan, pengembangan pegawai dan persepsi peran secara simultan berpengaruh signifikan terhadap kinerja Penyidik PPNS HKI sebesar 72,10% sedangkan sisa¬nya sebesar 27,90% dipengaruhi oleh variabel lain yang tidak termasuk dalam penelitian ini. Secara parsial masing-masing faktor kepemimpinan berpengaruh signifikan sebesar 24,40%, pengembangan pegawai signifikan sebe¬sar 26,01% sedangkan persepsi peran secara parsial tidak signifikan karena pengaruhnya sangat kecil, hanya sebesar 1,74% pada taraf nyata 5%. Dengan demikian pengembangan pegawai berpengaruh dominan terha¬dap kinerja Penyidik PPNS HKI Kantor Wilayah Dep. Hukum dan HAM Provinsi Se-Sumatera.Kata Kunci: Kinerja, praktek kepemimpinan, pengembangan dan persepsi peran.

  5. PENGARUH LEVEL OF ASSURANCE, REPUTASI KANTOR AKUNTAN PUBLIK, STRUKTUR MODAL CALON DEBITUR, DAN UKURAN BANK TERHADAP KEPUTUSAN PEMBERIAN KREDIT BANK DI INDONESIA

    Directory of Open Access Journals (Sweden)

    Elisa Tjondro

    2007-01-01

    Full Text Available This research intends to know the influence of the level of assurance, CPA firm's reputation, aspirant debitor's capital structure and bank size on bank loan decisions. The applied regression technique used to solve this problem are Chi-square test, Friedman test and Regression with the help of software SPSS 10th version. This research's results proved that the aspirant debitor's capital structure and bank size have influence on bank lending decisions, while level of assurance and CPA firm's reputation proved of no influence on bank lending decisions. From these two variables, aspirant debitor's capital structure has the highest impact on bank loan decisions in Indonesia. Abstract in Bahasa Indonesia : Penelitian ini bertujuan untuk mengetahui apakah level of assurance, reputasi kantor akuntan publik, struktur modal calon debitur, dan ukuran bank mempengaruhi keputusan pemberian kredit oleh bank. Teknik analisis yang digunakan untuk memecahkan masalah tersebut adalah Chi-square test, Friedman test, dan Regresi dengan memakai alat bantu software SPSS versi 10.0. Penelitian ini membuktikan bahwa struktur modal calon debitur dan ukuran bank berpengaruh terhadap keputusan pemberian kredit bank, sedangkan variabel level of assurance dan reputasi kantor akuntan publik terbukti tidak mempengaruhi keputusan pemberian kredit bank. Dari kedua variabel tersebut, struktur modal adalah variabel yang memiliki tingkat pengaruh paling tinggi terhadap keputusan pemberian kredit bank di Indonesia. Kata kunci: level of assurance, keputusan pemberian kredit bank.

  6. Pengembangan Model Pengelolaan Arsip (Surat dan Dokumen Pemerintah Berbasis Web pada Kantor Pemerintah Kabupaten Sidrap Provinsi Sulawesi Selatan

    Directory of Open Access Journals (Sweden)

    . Imasita

    2016-05-01

    Full Text Available Permasalahan yang dihadapi oleh kantor Pemerintah Kabupaten Sidrap Provinsi Sulawesi Selatan adalah fasilitas penyimpanan arsip (surat dan dokumen tidak sebanding dengan jumlah arsip dan dokumen yang selalu bertambah, penataan  dan penyimpanan arsip belum dikelola dengan profesional, belum ada sistem khusus yang diberlakukan dalam mengelola arsip dan dokumen tersebut. Berdasarkan masalah tersebut di atas, akan dilakukan penelitian. Tujuan adalah untuk memperoleh hasil analisis kinerja pengelolaan arsip dan dokumen pemerintah, untuk memperoleh hasil analisis dan mengidentifikasi masalah yang dialami dalam pengelolaan arsip (surat dan dokumen pemerintah, dan untuk melakukan analisis kebutuhan, desain produk, pengembangan produk  model pengelolaan arsip yang dapat membantu dalam penyajian arsip (surat dan dokumen dengan cepat, tepat dan dapat diakses secara on line oleh semua pegawai. Penelitian ini menggunakan metode waterfall. Aktifitas yang dilakukan dengan analisis kebutuhan. Perancangan sistem. Pemrograman dengan pemanfaatan Wamp Server, dan pengujian sistem. black box test. Hasil penelitian ini menunjukan bahwa pengelolaan arsip (surat atau dokumen pemerintah kabupaten Sidrap Propinsi Sulawesi Selatan menggunakan sistem kearsipan pola lama (sistem manual. Kelebihan program ini adalah: a Menyiapkan buku agenda secara on line b  Memudahkan penemuan fisik arsip dengan cara cepat dan tepat. Pencarian arsip dapat dilakukan berdasarkan asal surat, tanggal surat, tanggal terima/kirim, perihal surat, isi ringkas surat dan lain-lain  c Fisik arsip dapat ditemukan atau diakses oleh semua pegawai  secara on line. Program ini menyiapkan menu print untuk mencetak arsip tersebut. Program ini masih dilakukan penyempurnaan pada tahun ke dua.Kata Kunci: Arsip (surat dan Dokumen Pemerintah

  7. Triple acting radial seal

    Science.gov (United States)

    Ebert, Todd A [West Palm Beach, FL; Carella, John A [Jupiter, FL

    2012-03-13

    A triple acting radial seal used as an interstage seal assembly in a gas turbine engine, where the seal assembly includes an interstage seal support extending from a stationary inner shroud of a vane ring, the interstage seal support includes a larger annular radial inward facing groove in which an outer annular floating seal assembly is secured for radial displacement, and the outer annular floating seal assembly includes a smaller annular radial inward facing groove in which an inner annular floating seal assembly is secured also for radial displacement. A compliant seal is secured to the inner annular floating seal assembly. The outer annular floating seal assembly encapsulates the inner annular floating seal assembly which is made from a very low alpha material in order to reduce thermal stress.

  8. TRIPLE ACTION PALATE EXPANDER

    Directory of Open Access Journals (Sweden)

    Svetlana Yordanova

    2011-09-01

    Full Text Available Malocclusion correction essentially involves expansion of the maxilla, protrusion of anterior teeth and opening the bite. Expansion is often the stage preceding the treatment with fixed appliances. The elevation of the occlusion using accomplished with different devices (bite planes -fixed or removable, composite material on the occlusall surface of molars carries the risk of breaking or debonding them.The present article proposes an expanding appliance with triple action as a therapeutic means of choice in an orthodontic treatment with fixed appliances. The expander can simultaneously be used to protrude upper teeth, to expand the upper jaw and disarticulate the occlusion. It can be easily fabricated in clinical conditions, causes no discomfort and does not hamper oral hygiene because it can be removed and cleaned.

  9. Triple-resonant transducers.

    Science.gov (United States)

    Butler, Stephen C

    2012-06-01

    A detailed analysis is presented of two novel multiple-resonant transducers which produce a wider transmit response than that of a conventional Tonpilz-type transducer. These multi-resonant transducers are Tonpilz-type longitudinal vibrators that produce three coupled resonances and are referred to as triple-resonant transducers (TRTs). One of these designs is a mechanical series arrangement of a tail mass, piezoelectric ceramic stack, central mass, compliant spring, second central mass, second compliant spring, and a piston-radiating head mass. The other TRT design is a mechanical series arrangement of a tail mass, piezoelectric ceramic stack, central mass, compliant spring, and head mass with a quarter-wave matching layer of poly(methyl methacrylate) on the head mass. Several prototype transducer element designs were fabricated that demonstrated proof-of-concept.

  10. PENGARUH KEMAMPUAN KERJA, FASILITAS KERJA, DAN PRINSIP PROSEDUR KERJA TERHADAP KINERJA PEGAWAI DI KANTOR KECAMATAN SE KABUPATEN BATANG

    Directory of Open Access Journals (Sweden)

    Iswatun Chasanah

    2017-06-01

    Full Text Available Kinerja adalah suatu hasil kerja baik secara kualitas maupun kuantitas yang dicapai seseorang untuk mencapai tujuan tertentu yang didukung oleh faktor internal pegawai maupun faktor lingkungan internal organisasi seperti kemampuan kerja yang baik, fasilitas yang memadai serta prosedur kerja yang memiliki prinsip yang jelas. Penelitian ini bertujuan untuk mengetahui adakah pengaruh antara kemampuan kerja, fasilitas kerja, dan prinsip prosedur kerja terhadap kinerja pegawai secara simultan maupun parsial. Sampel sebanyak 113 pegawai dari 5 Kantor Kecamatan yang diambil dengan teknik Cluster Sampling. Pengumpulan data menggunakan metode dokumentasi dan angket. Analisis data dengan menggunakan Regresi linier Berganda, Uji Asumsi Klasik, dan Analisis Deskriptif Presentase. Hasil analisis regresi linier berganda diperoleh persamaan Y = 10,137+0,384X1+0,180X2+0,387X3 + e. Hasil uji F diperoleh nilai signifikansi sebesar 0,000 yang menunjukkan bahwa secara simultan ada pengaruh positif dan signifikan antara kemampuan kerja, fasilitas kerja, dan prinsip prosedur kerja terhadap kinerja pegwai yaitu sebesar 27,2%. Sedangkan pengaruh secara parsial untuk kemampuan kerja sebesar 5,01%, fasilitas kerja sebesar 5,42%, dan prinsip prosedur kerja sebesar 18,6%. Performance is a work result both quality and quantity work achieved by a person to achieve the certain goal that is supported by internal factors of employees and internal factors environmental of organization such as a good work ability, adequate work facilities and job procedures that have clear principle. The purposes of this research was to identify the influence of the work ability, working facilities, and the principle of job procedures to performance of employees simultaneously or partially. Sample were 113 employees of 5 district offices which were taken by Cluster Sampling. Data were collected by using documentation and questionnaires method. Analysis using multiple linear regression, classical

  11. PENGARUH KEMAMPUAN KERJA PEGAWAI, ETOS KERJA DAN SEMANGAT KERJA TERHADAP KUALITAS PELAYANAN DI KANTOR KECAMATAN SALE KABUPATEN REMBANG

    Directory of Open Access Journals (Sweden)

    Nur Afifah

    2014-11-01

    Full Text Available Tujuan dari penelitian ini adalah untuk mengetahui adanya pengaruh kemampuan kerja pegawai, etos kerja dan semangat terhadap kualitas pelayanan di kantor kecamatan Sale kabupaten Rembang secara simultan maupun parsial. Populasi dari penelitian ini adalah seluruh masyarakat kecamatan Sale kabupaten Rembang yang menerima pelayanan pada tahun 2013 sebanyak 5041 orang. Sampel dari penelitian ini sebanyak 100 orang, menggunakan teknik sampel nonprobability sampling yaitu sampling incidental yang berarti teknik penentuan sampel berdasarkan kebetulan bila dipandang orang yang kebetulan ditemui itu cocok sebagai sumber data. Metode pengumpulan data yang digunakan adalah metode dokumentasi, kuesioner dan observasi. Teknik analisis data menggunakan analisis deskriptif dan analisis regresi linier berganda. Hasil analisis regresi menunjukkan persamaan garis regresi linier bergandaY= 0,907+0,460X1+0,345X2+0,286X3. Hasil perhitungan menunjukkan besarnya pengaruh secara parsial pengaruh kemampuan kerja terhadap kualitas pelayanan sebesar 2,810, pengaruh etos kerja terhadap kualitas pelayanan sebesar 4,599, dan pengaruh semangat kerja terhadap kualitas pelayanan sebesar 2,466. Pengaruh secara simultan kemampuan kerja, etos kerja dan semangat kerja terhadap kualitas pelayanan sebesar 67,842. The purpose of this study was to knowing how to influence job skill employee, work ethics and entusiasm the service quality in the Sale subdistrict office, Rembangby partially or simultaneously. The population of this study were all people in Sale subdistrict office, Rembang serviced of 5041 people in 2013. The samples of this study were 100 people, used a nonprobability sampling technique which was an incidental sampling. The incidental sampling was used to collect the sample accidentally if the people were qualified as the data sources. The data were collectedby documentation, questionnaire, and observation. Then, the datawere analyzedby descriptive analysis and linear

  12. Image Processing dan Artifical Neural Network Untuk Mengenali Nomor Induk Kependudukan Pada KTP Sebagai Pendukung Layanan Mandiri di Kantor Desa

    Directory of Open Access Journals (Sweden)

    Jaroji Jaroji

    2017-11-01

    Full Text Available AbstrakPelayanan prima yang cepat dan tepat harus diberikan oleh pemerintah desa kepada masyarakat. Namun kesan layanan birokrasi pemerintahan berbelit-belit sudah menjadi pemikiran kebanyakan masyarakat. Hal ini didasari atas fakta yang masyarakat alami sendiri ketika mereka memanfaatkan layanan di kantor desa. Sistem layanan mandiri dapat menjadi solusi untuk mengurangi jalur birokrasi yang dianggap berbelit-belit tersebut tanpa harus menghilangkan peran pihak-pihak terkait. Pada sistem layanan mandiri ini masyarakat dapat mengakses layanan seperti mengurus surat keterangan dan surat pengantar untuk berbagai keperluan. Untuk meminimalkan proses pengetikan oleh masyarakat digunakan image processing untuk mendapatkan data Nomor Induk Kepenedudukan (NIK pada KTP. Image processing dilakukan dengan cara bileveling, smearing, penentuan baris dan ekstrasi citra digital ke citra biner yang menghasilkan vektor. Pola vektor tersebut di uji dengan jaringan syaraf tiruan metode backpropagation yang telah dilatih menggunakan 61 unit vektor data sampel. Hasilnya jaringan syaraf tiruan mampu mengenali (NIK pada KTP, NIK tersebut dijadikan input pada system layanan mandiri. Kata kunci: Pengolahan citra, Run Lenght Smearing Algorithm, Jaringan Syafat tiruan, Backpropation AbstractExcellent service should be provided promptly by the village government to the community. However, the impression of bureaucratic government service has become the most people thought. This is based on the facts that people themselves experience when they make use of the services in the village office. Self-service system can be a solution to reduce the bureaucratic path that is considered convoluted without having to eliminate the role of the parties concerned. In this self-service system the community can access services such as taking care of certificates and cover letters for various purposes. To minimize typing activities by community used image processing to obtain data

  13. PENGARUH FAKTOR-FAKTOR MOTIVASI TERHADAP KINERJA PEGAWAI DI PT. BANK BNI SYARIAH KANTOR CABANG JAKARTA BARAT DAN BOGOR

    Directory of Open Access Journals (Sweden)

    Atika Dyah Perwita

    2017-01-01

    dilakukan dengan metode Partial Least Square (PLS. Hasil analisis pengaruh faktor-faktor motivasi terhadap kinerja menunjukkan bahwa motivator dan hygiene factor keduanya berpengaruh terhadap kinerja pegawai. Adapun faktor-faktor yang paling berpengaruh terhadap kinerja pegawai PT. Bank BNI Syariah Kantor Cabang (KC Jakarta Barat dan Bogor adalah hygiene factor. Indikator yang paling dominan dalam merefleksikan hygiene factor dalam membangun kinerja pegawai adalah kondisi kerja dan hubungan interpersonal.Kata kunci: hygiene factor, kinerja, motivasi ekstrinsik, motivasi intrinsik, motivator

  14. Another simple proof of the quintuple product identity

    Directory of Open Access Journals (Sweden)

    Hei-Chi Chan

    2005-01-01

    Full Text Available We give a simple proof of the well-known quintuple product identity. The strategy of our proof is similar to a proof of Jacobi (ascribed to him by Enneper for the triple product identity.

  15. Respuestas de J.R. Kantor y de B.F. Skinner a las preguntas epistemológicas básicas

    OpenAIRE

    Blanca Patricia Ballesteros; Amanda Rey

    2001-01-01

    Diferentes variables académicas, científicas y sociales hacen necesario el escrutinio de las categorías de clase de los diferentes conductismos en un marco epistemológico. El presente artículo hace una comparación entre el Interconductismo de J. R. Kantor y el Conductismo Radical de B. F. Skinner. Las preguntas para las cuales se identifican las posturas de cada autor y su evolución histórica son: (1) ¿Qué es conocimiento?, (2) ¿Qué se conoce?, (3) ¿Cómo se conoce?, (4) ¿Para qué se ...

  16. Harmonic analysis on triple spaces

    DEFF Research Database (Denmark)

    Danielsen, Thomas Hjortgaard

    In this thesis we study examples of triple spaces, both their structure theory, their invariant differential operators as well as analysis on them. The first major results provide us with some examples of triple spaces which are strongly spherical, i.e. satisfy some conditions reminiscent...... of properties of symmetric spaces. The algebras of invariant differential operators for these spaces are studied and the conclusion is that most of them are non-commutative. Finally, we restrict our attention to a single triple space, giving a specific polar decomposition and corresponding integration formula......, and studying the relations between open orbits of parabolic subgroups, multiplicities and distribution vectors....

  17. Simple machines

    CERN Document Server

    Graybill, George

    2007-01-01

    Just how simple are simple machines? With our ready-to-use resource, they are simple to teach and easy to learn! Chocked full of information and activities, we begin with a look at force, motion and work, and examples of simple machines in daily life are given. With this background, we move on to different kinds of simple machines including: Levers, Inclined Planes, Wedges, Screws, Pulleys, and Wheels and Axles. An exploration of some compound machines follows, such as the can opener. Our resource is a real time-saver as all the reading passages, student activities are provided. Presented in s

  18. Triple-band metamaterial absorption utilizing single rectangular hole

    Science.gov (United States)

    Kim, Seung Jik; Yoo, Young Joon; Kim, Young Ju; Lee, YoungPak

    2017-01-01

    In the general metamaterial absorber, the single absorption band is made by the single meta-pattern. Here, we introduce the triple-band metamaterial absorber only utilizing single rectangular hole. We also demonstrate the absorption mechanism of the triple absorption. The first absorption peak was caused by the fundamental magnetic resonance in the metallic part between rectangular holes. The second absorption was generated by induced tornado magnetic field. The process of realizing the second band is also presented. The third absorption was induced by the third-harmonic magnetic resonance in the metallic region between rectangular holes. In addition, the visible-range triple-band absorber was also realized by using similar but smaller single rectangular-hole structure. These results render the simple metamaterials for high frequency in large scale, which can be useful in the fabrication of metamaterials operating in the optical range.

  19. PENGARUH MOTIVASI BELAJAR, DISIPLIN BELAJAR DAN MEDIA PEMBELAJARAN TERHADAP KESIAPAN BELAJAR SISWA KELAS X ADMINISTRASI PERKANTORAN PADA MATA DIKLAT MENGELOLA PERALATAN KANTOR DI SMK NU 01 KENDAL

    Directory of Open Access Journals (Sweden)

    Ayu Fitria Yanida, Hengky Pramusinto

    2014-11-01

    Full Text Available Tujuan penelitian ini adalah untuk mengetahui Pengaruh motivasi belajar, disiplin belajar dan media pembelajaran terhadap kesiapan belajar siswa kelas X administrasi perkantoran pada mata diklat mengelola peralatan kantor di SMK NU 01 Kendal baik secara simultan maupun parsial.Populasi dalam penelitian ini adalah siswa kelas X jurusan administrasi perkantoran sebanyak 94siswa.Metode pengumpulan data yang digunakan adalah metode kuesioner dan dokumentasi.Teknik analisis data menggunakan analisis deskriptif persentase, analisis regresi linier berganda, analisis uji asumsi klasik, dan analisis uji hipotesis.Analisis regresi berganda menunjukkan bahwa ada pengaruh motivasi belajar, disiplin belajar dan media pembelajaran terhadap kesiapan belajar siswa kelas X administrasi perkantoran pada mata diklat mengelola peralatan kantor di SMK NU 01 Kendal baik secara simultan maupun parsial. Preparation to studyis the basic need that must be done by students Office Equipment learning outcomes. Learning readiness can be influenced by learning motivation, learning discipline and learning media. The problem of this study:Was there are any influence of learning motivation, learning discipline and learning media toward the 10th grade students’ learning readiness of OfficeAdministration in managing Office Equipment in SMK NU 01 Kendal. The population were 10thgrade student of Office Administration at SMK NU 01 Kendal, they were 94 students. The data were collected by questiononaires and documentation. The data were analyzed by percentage desciptive analiysis, multiple linear regression analysis, analysis classical assumption test, hypothesis testing and SPSS analysis. The results of multiple linear regression analysis showed that the equation Y = 7.472 + 0.163X1 + 0.155X2+ 0.369X3, with F test was obtained F = 16.278 with a significance 0.000 and less than 0.05. Simultaneously, the influence of learning motivation, learning discipline and learning media toward

  20. On split Lie triple systems

    Indian Academy of Sciences (India)

    The key tool in this job is the notion of connection of roots in the framework of split Lie triple systems. Author Affiliations. Antonio J Calderón Martín1. Departamento de Matemáticas, Universidad de Cádiz, 11510 Puerto Real, Cádiz, Spain. Dates. Manuscript received: 25 January 2008. Proceedings – Mathematical Sciences.

  1. Solution Patterns Predicting Pythagorean Triples

    Science.gov (United States)

    Ezenweani, Ugwunna Louis

    2013-01-01

    Pythagoras Theorem is an old mathematical treatise that has traversed the school curricula from secondary to tertiary levels. The patterns it produced are quite interesting that many researchers have tried to generate a kind of predictive approach to identifying triples. Two attempts, namely Diophantine equation and Brahmagupta trapezium presented…

  2. Respuestas de J.R. Kantor y de B.F. Skinner a las preguntas epistemológicas básicas

    Directory of Open Access Journals (Sweden)

    Blanca Patricia Ballesteros

    2001-01-01

    Full Text Available Diferentes variables académicas, científicas y sociales hacen necesario el escrutinio de las categorías de clase de los diferentes conductismos en un marco epistemológico. El presente artículo hace una comparación entre el Interconductismo de J. R. Kantor y el Conductismo Radical de B. F. Skinner. Las preguntas para las cuales se identifican las posturas de cada autor y su evolución histórica son: (1 ¿Qué es conocimiento?, (2 ¿Qué se conoce?, (3 ¿Cómo se conoce?, (4 ¿Para qué se conoce?, y (5 ¿Cuáles son los criterios de validez del conocimiento? La revisión lleva a concluir que aún cuando cada autor desarrolló líneas de trabajo diferentes, ambos compartieron intereses respecto de la psicología como ciencia del comportamiento y coincidieron en fundamentos epistemológicos y ontológicos que han facilitado el desarrollo de nuevos conductismos como es el caso del conductismo empírico y del funcionalismo contextual.

  3. APLIKASI SISTEM INFORMASI PERTANAHAN BERDASARKAN JENIS-JENIS HAK ATAS TANAH DI KANTOR PERTANAHAN KOTA SURABAYA II (STUDI KASUS KELURAHAN GENTENG, KECAMATAN GENTENG, SURABAYA

    Directory of Open Access Journals (Sweden)

    Ery Abdul Baary

    2015-02-01

    Full Text Available Di Kantor Pertanahan Kota Surabaya II, sistem informasi pertanahan belum diterapkan, jadi untuk melaksanakan tugasnya hanya menggunakan sebatas peta digital, maka dari itu perlu adanya sistem informasi pertanahan yang terpadu dan mutakhir untuk mendukung dan mengoptimalkan pengelolaan sistem informasi pertanahan di Kota Surabaya II.Pada penelitian ini akan dilakukan pembuatan sistem informasi pertanahan berdasarkan jenis hak atas tanah dengan menggunakan peta digital Kelurahan Genteng, Kecamatan Genteng, Surabaya skala 1:1000, citra Quickbird 2010, database mengenai bidang tanah dan data hasil survey. Pengolahan data menggunakan software utama Autodesk Land Dekstop 2009, ArcGIS 9.3. Pembuatan program aplikasi menggunakan software Visual Basic 6.0 yang dilengkapi dengan software tambahan MapObject 2.2.Dari hasil pembuatan Sistem informasi pertanahan di Kelurahan Genteng, Program ini mampu mengidentifikasi informasi bidang tanah mengenai jenis hak atas tanah yang meliputi 224 bidang tanah yang terdiri dari 132 bidang tanah atas hak guna bangunan, 89 bidang tanah atas hak milik, dan 3 bidang tanah atas hak pakai, serta dilengkapi dengan buku panduan sehingga dapat digunakan untuk membantu dalam pengambilan kebijakan dalam rencana pelaksanaan program inventarisasi penguasaan, pemilikan, penggunaan, dan pemanfaatan tanah.

  4. An iron-capped metal-organic polyyne: {[Fe](C[triple bond]C)2[W][triple bond]CC[triple bond]CC[triple bond][W](C[triple bond]C)2[Fe]}.

    OpenAIRE

    Semenov Sergey N; Taghipourian Shiva F; Blacque Olivier; Fox Thomas; Venkatesan Koushik; Berke Heinz

    2010-01-01

    The organometallic conjugated complex H(C[triple bond]C)(2)[W][triple bond]CC[triple bond]CC[triple bond][W](C[triple bond]C)(2)H {[W] = W(dppe)(2); dppe = 12 bis(diphenylphosphino)ethane} containing a ditungstenatetradecaheptayne unit was synthesized by utilizing a new and efficient coupling method. The stannylated derivative was converted to the tetranuclear complex which exhibits efficient long range electron transfer.

  5. Triple-negative breast cancer

    OpenAIRE

    Chacón, Reinaldo D; Costanzo, María V

    2010-01-01

    Perou's molecular classification defines tumors that neither express hormone receptors nor overexpress HER2 as triple-negative (TN) tumors. These tumors account for approximately 15% of breast cancers. The so-called basaloid tumors are not always synonymous with TN tumors; they differ in the fact that they express different molecular markers, have a higher histologic grade, and have a worse prognosis. Clinically they occur in younger women as interval cancer, and the risk of recurrence is hig...

  6. [Julija Z. Kantor. Pribaltika. Vojna bez pravil (1939-1945) Sankt-Peterburg, 2011 ; Lev F. Sockov. Pribaltika i geopolitika 1935-1945 gg. Rassekreennye dokumenty Služby vnešnej razvedki Rossiskoj Federacii. Moskva, 2009 ; Anatolij A. Sazonov. "Sove

    Index Scriptorium Estoniae

    Makhotina, Ekaterina, 1982-

    2014-01-01

    Arvustus: Julija Z. Kantor. Pribaltika. Vojna bez pravil (1939-1945) Sankt-Peterburg, 2011 ; Lev F. Sockov. Pribaltika i geopolitika 1935-1945 gg. Rassekreennye dokumenty Služby vnešnej razvedki Rossiskoj Federacii. Moskva, 2009 ; Anatolij A. Sazonov. "Sovetskaja okkupacija" Pribaltiki v archivnych dokumentach. Projekt "Argumenty istiny". Moskva, 2009

  7. The evolution of triple-star systems

    Science.gov (United States)

    Toonen, Silvia; Hamers, Adrian; Portegies Zwart, Simon

    2017-01-01

    While the principles of stellar and binary evolution theory have been accepted for a long time, our understanding of triple-star evolution is lagging behind. It is important to understand these systems, as triples are common in the field. About 15% of low-mass stellar systems are triples, but for high-mass stars the fraction increases to over 50%. At the same time, triple evolution is often invoked to explain exotic systems which cannot be explained easily by binary evolution. Examples are low-mass X-ray binaries, supernova type Ia progenitors and blue stragglers.Modeling triple evolution, however, is challenging as it is a combination of three-body dynamics and stellar evolution. In the past, most studies of three-body systems have focused on purely dynamical aspects without taking stellar evolution into account. However, in recent years, the first interdisciplinary studies have taken place which demonstrate the richness of the interacting regime. Here, I will show the first results of our new code TRES for simulating the evolution of stellar triples, which combines stellar evolution and interactions with three-body dynamics. In this talk, I will give an overview of the evolution of realistic (stellar) triples and I will discuss how triple evolution differs from binary evolution. What are the common evolutionary pathways that triple systems evolve through? Are there any evolutionary pathways open to triples, which are not open to isolated binaries? These are some of the important questions we want to answer.

  8. Energy Efficient Triple IG Automation EEE (Triple-E)

    Energy Technology Data Exchange (ETDEWEB)

    McGlinchy, Timothy B

    2013-02-28

    GED Integrated Solutions collaborated with US window and door manufactures to investigate, design and verify technical and cost feasibility for producing high performance, high volume, low material and labor cost window, utilizing a modified window design containing a triple insulating glass unit (IGU). This window design approach when combined with a high volume IGU manufacturing system, can produce R5 rated windows for an approximate additional consumer cost of only $4 per square foot when compared to conventional Low-E argon dual pane IG windows, resulting in a verify practical, reliable and affordable high performance window for public use.

  9. Regular matrix transformation on triple sequence spaces

    Directory of Open Access Journals (Sweden)

    Shyamal Debnath

    2017-10-01

    Full Text Available The main aim of this paper is to introduce the necessary and sufficient condition for a particular type of transformation of the form A: (a......  be regular from a triple sequence space to another triple sequence space.

  10. Holonomy loops, spectral triples and quantum gravity

    DEFF Research Database (Denmark)

    Johannes, Aastrup; Grimstrup, Jesper Møller; Nest, Ryszard

    2009-01-01

    We review the motivation, construction and physical interpretation of a semi-finite spectral triple obtained through a rearrangement of central elements of loop quantum gravity. The triple is based on a countable set of oriented graphs and the algebra consists of generalized holonomy loops...

  11. Spectral triples and the geometry of fractals

    DEFF Research Database (Denmark)

    Christensen, Erik; Ivan, Cristina; Schroe, Elmar

    2012-01-01

    It is shown that one can construct a spectral triple for the Sierpinski gasket such that it represents any given K-homology class, On the other hand if the geodesic distance and the dimension has to be part of the data from the triple, there are certain restriction....

  12. Simple spectrophotometric determination of monopersulfate.

    Science.gov (United States)

    Wacławek, S; Grübel, K; Černík, M

    2015-10-05

    A simple, sensitive and accurate spectrophotometric method has been developed and validated for the determination of monopersulfate (MPS) which is an active part of potassium monopersulfate triple salt that has the commercial name - Oxone. This work proposes a spectrophotometric determination of monopersulfate based on modification of the iodometric titration method. The analysis of absorption spectra was made for the concentration range from 1.35 to 13.01 ppm of MPS (with a detection and quantification limit of 0.41 and 1.35 ppm, respectively) and different pH values. The influence of several anions on the measurement was also investigated. Furthermore, the absorbance of iron and cobalt (often used as free radical initiators) proved to have no effect on the measurement of MPS concentrations. On the basis of the conducted studies, we propose 395 nm as an optimal wavelength for the determination of MPS concentrations. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. Factors influencing the eradication of Helicobacter pylori with triple therapy.

    Science.gov (United States)

    Graham, D Y; Lew, G M; Malaty, H M; Evans, D G; Evans, D J; Klein, P D; Alpert, L C; Genta, R M

    1992-02-01

    Helicobacter pylori infection has been associated with gastritis, duodenal ulcer, gastric ulcer, and the epidemic form of gastric carcinoma. Eradication of H. pylori infection has proven to be difficult. Recently, combinations of antimicrobial drugs have been shown to eradicate greater than 50% of infections; however, the results have proven variable, and the factors influencing effectiveness of therapy are unclear. In the present study, the effectiveness of a triple therapy for eradication of H. pylori infection was evaluated. Triple therapy consisted of 2 g tetracycline, 750 mg metronidazole, and five or eight tablets of bismuth subsalicylate daily in 93 patients (70 with duodenal ulcer, 17 with gastric ulcer, and 6 with simple H. pylori gastritis). Combinations of a sensitive urea breath test, serology, culture, and histology were used to confirm the presence of infection, eradication, or relapse. Eradication was defined as inability to show H. pylori greater than or equal to 1 month after ending therapy. The overall eradication rate was 87%. The factors evaluated for their effect on predicting eradication included age, gender, type of disease, duration of therapy, amount of bismuth subsalicylate [five or eight Pepto-Bismol tablets daily (Procter & Gamble, Cincinnati, OH)], and compliance with the prescribed medications. Stepwise regression showed that compliance was the most important factor predicting success; the success rate was 96% for patients who took greater than 60% of the prescribed medications and 69% for patients who took less. For those taking greater than 60% of the prescribed therapy, the eradication rates were similar (a) for patients receiving therapy for 14 days or when tetracycline and bismuth subsalicylate were taken for an additional 14 days; (b) for patients with duodenal ulcer, gastric ulcer, and simple H. pylori gastritis; and (c) whether five or eight bismuth subsalicylate tablets were taken. It is concluded that triple therapy is

  14. Pengaruh Audit Pajak Terhadap Peningkatan Penerimaan Pajak (Studi Kasus pada Kantor Pelayanan Pajak Pratama Cicadas Kota Bandung)

    OpenAIRE

    Khansa, Galuh Aqila

    2016-01-01

    This research aims are to understand the effect and connection between tax audit and tax income in KPP Pratama Cicadas Bandung. This is an associative causal research with 3 years samples from 2012-2014 or 36 samples. This research used simple regression analysis and correlation analysis. Variables in this research are tax audit that is measured by numbers of tax statement invoice and tax income that is measured by total income of tax every month. Research shows that tax audit has positive an...

  15. PENANGANAN PENGADUAN MASYARAKAT SEBAGAI PENDUKUNG IKLIM ORGANISASI (Studi Deskriptif Kualitatif Penanganan Pengaduan Masyarakat di Seksi Informasi dan Sarana Komunikasi Kantor Imigrasi Kelas I Y ogyakarta

    Directory of Open Access Journals (Sweden)

    Widya Larasati

    2016-04-01

    Full Text Available Abstrak Penanganan pengaduan menjadi hal yang penting sebagai sarana memperbaiki kualitas kerja maupun pelayanan dalam sebuah organisasi. Penelitian ini menjelaskan tentang penanganan pengaduan yang dilakukan oleh Seksi Informasi dan Sarana Komunikasi sebagai divisi yang menangani aduan yang diterima oleh Kantor Imigrasi Kelas I Yogyakarta. Pengaduan yang diterima oleh organisasi dapat mempengaruhi pegawai dalam bekerja. Penelitian ini menggambarkan bagaimana penanganan pengaduan masyarakat mendukung iklim organisasi di seksi tersebut. Iklim organisasi yang positif mampu mempengaruhi kualitas kinerja pegawai sehingga pelayanan yang diberikan organisasi akan semakin baik. Penelitian ini menggunakan metode deskriptif kualitatif. Teknik pengambilan data menggunakan observasi, wawancara mendalam dan dokumentasi. Untuk melihat keabsahan data, peneliti menggunakan triangulasi sumber.Hasil dari penelitian ini menunjukkan bahwa penanganan pengaduan masyarakat mendukung iklim organisasi di seksi tersebut sesuai dengan dimensi iklim organisasi menurut Stringer yang meliputi struktur, standar-standar, tanggungjawab, penghargaan, dukungan dan komitmen. Iklim organisasi di seksi tersebut menjadi kondusif karena pegawai merasa memiliki tanggung jawab yang tinggi untuk menyelesaikan pengaduan yang ada, saling mendukung dan mencari solusi secara bersama-sama. Bahkan, derajat kebanggaan dalam bekerja, motivasi untuk bekerja lebih baik lagi serta kesetiannya terhadap organisasi semakin meningkat karena penanganan pengaduan masyarakat tersebut. Kata kunci: penanganan pengaduan masyarakat, iklim organisasi   Abstract Complaint handling becomes an important thing that can be a medium to improve the quality of work or services in an organization. This research describes about complaint handling in Information and Communication section as the division that handles the complaint received by Imigrasi Kelas I Yogyakarta office. Complaints that received by organization

  16. Triple X Syndrome: Symptoms and Causes

    Science.gov (United States)

    ... help determine the cause and suggest appropriate action. Causes Although triple X syndrome is genetic, it's usually not inherited — it's due to a random genetic error. Normally, people have 46 chromosomes in each cell, ...

  17. The triple helix perspective of innovation systems

    NARCIS (Netherlands)

    Leydesdorff, L.; Zawdie, G.

    2010-01-01

    Alongside the neo-institutional model of networked relations among universities, industries, and governments, the triple helix can be provided with a neo-evolutionary interpretation as three selection environments operating upon one another: markets, organisations and technological opportunities.

  18. Triple ion beam irradiation facility

    Energy Technology Data Exchange (ETDEWEB)

    Lewis, M.B.; Allen, W.R.; Buhl, R.A.; Packan, N.H.; Cook, S.W.; Mansur, L.K.

    1988-12-01

    A unique ion irradiation facility consisting of three accelerators is described. The accelerators can be operated simultaneously to deliver three ion beams on one target sample. The energy ranges of the ions are 50 to 400 keV, 200 keV to 2.5 MeV, and 1.0 to 5.0 MeV. Three different ions in the appropriate mass range can be simultaneously implanted to the same depth in a target specimen as large as 100 mm/sup 2/ in area. Typical depth ranges are 0.1 to 1.0 ..mu..m. The X-Y profiles of all three ion beams are measured by a system of miniature Faraday cups. The low-voltage accelerator can periodically ramp the ion beam energy during the implantation. Three different types of target chambers are in use at this facility. The triple-beam high-vacuum chamber can hold nine transmission electron microscopy specimens at elevated temperature during a irradiation by the three simultaneous beams. A second high-vacuum chamber on the medium-voltage accelerator beamline houses a low- and high-temperature translator and a two-axis goniometer for ion channeling measurements. The third chamber on the high-energy beamline can be gas-filled for special stressed specimen irradiations. Special applications for the surface modification of materials with this facility are described. Appendixes containing operating procedures are also included. 18 refs., 27 figs., 1 tab.

  19. Triple oxygen isotope systematics of structurally bonded water in gypsum

    Science.gov (United States)

    Herwartz, Daniel; Surma, Jakub; Voigt, Claudia; Assonov, Sergey; Staubwasser, Michael

    2017-07-01

    The triple oxygen isotopic composition of gypsum mother water (gmw) is recorded in structurally bonded water in gypsum (gsbw). Respective fractionation factors have been determined experimentally for 18O/16O and 17O/16O. By taking previous experiments into account we suggest using 18αgsbw-gmw = 1.0037; 17αgsbw-gmw = 1.00195 and θgsbw-gmw = 0.5285 as fractionation factors in triple oxygen isotope space. Recent gypsum was sampled from a series of 10 ponds located in the Salar de Llamara in the Atacama Desert, Chile. Total dissolved solids (TDS) in these ponds show a gradual increase from 23 g/l to 182 g/l that is accompanied by an increase in pond water 18O/16O. Gsbw falls on a parallel curve to the ambient water from the saline ponds. The offset is mainly due to the equilibrium fractionation between gsbw and gmw. However, gsbw represents a time integrated signal biased towards times of strong evaporation, hence the estimated gmw comprises elevated 18O/16O compositions when compared to pond water samples taken on site. Gypsum precipitation is associated with algae mats in the ponds with lower salinity. No evidence for respective vital effects on the triple oxygen isotopic composition of gypsum hydration water is observed, nor are such effects expected. In principle, the array of δ18Ogsbw vs. 17Oexcess can be used to: (1) provide information on the degree of evaporation during gypsum formation; (2) estimate pristine meteoric water compositions; and (3) estimate local relative humidity which is the controlling parameter of the slope of the array for simple hydrological situations. In our case study, local mining activities may have decreased deep groundwater recharge, causing a recent change of the local hydrology.

  20. On split Lie triple systems

    Indian Academy of Sciences (India)

    ity of T . We can apply Theorem 4.1 to I[α0] to conclude I[α0] is simple and the proof is complete. 2. Acknowledgements. This work is supported by the PCI of the UCA 'Teorıa de Lie y Teorıa de Espacios de. Banach', by the PAI with project number FQM-298, by the project of the Spanish Ministerio de Educación y Ciencia ...

  1. ANALISIS BUTIR SOAPENGELOLAAN ARSIP INAKTIF DALAM UPAYA MENDUKUNG LAYANAN INFORMASI DI KANTOR ARSIP DAN PERPUSTAKAAN DAERAH KABUPATEN PURWOREJOL MATA PELAJARAN PENGANTAR ADMINISTRASI PERKANTORAN

    Directory of Open Access Journals (Sweden)

    Nita Rahmawati

    2016-02-01

    Full Text Available Penelitian ini menggunakan penelitian kualitatif. Sumber data dalam penelitian ini adalah Kepala Kantor Arsip dan Perpustakaan Daerah Kabupaten Purworejo, Kepala Bagian Tata Usaha, Kepala Seksi Akuisisi, Pengelolaan Arsip dan Dokumentasi,Staff Sub Tata Usaha,dan Arsiparis. Teknik pengumpulan data dalam penelitian ini menggunakan observasi, wawancara dan dokumentasi. Prosedur penelitian ini meliputi tahap pra-lapangan, tahap pekerjaan lapangan, dan tahap analisis data. Teknik analisis data meliputi pengumpulan data, reduksi data, penyajian data, dan menarik kesimpulan.Hasil penelitian menunjukkan bahwa pengelolaan arsip meliputi pencatatan arsip, pengendalian dan pendistribusian arsip, penyimpanan arsip, pemeliharaan arsip, pengawasan arsip, pemindahan dan pemusnahan arsip. Kendala yang ada antara lain masih adanya arsip yang menumpuk di ruang depo penyimpanan arsip, tidak adanya sanksi bagi peminjam arsip yang terlambat mengembalikan. Berdasarkan hasil penelitian ini dapat disimpulkan bahwa pencatatan arsip melalui kelengkapan arsip, pengendalian dan pendistribusian dengan tanggal terima, tanggal surat, paraf penerima. Sistem penyimpanan arsip yang digunakan adalah sistem penyimpanan kronologis (tanggal, pemeliharaan dengan membersihkan setiap sudut ruang arsip baik dengan kemoceng atau sapu dan memberikan kapur barus disela rak arsip juga melapisi arsip dengan kertas payung, pemindahan dan pemusnahan arsip dilakukan setiap periodik atau setahun sekali. Dengan demikian menyarankan : 1 mengoptimalkan ruang depo penyimpanan yang arsipnya masih ditumpuk dan belum diolah, 2 memberikan sanksi kepada peminjam arsip yang mengembalikan tidak tepat waktu. It was a qualitative research. The data source of the were the Head Office of Regional Library and Archive Office in Purworejo Regency, the Head of Administration, the Head Section of Procurement, Archives and Documentation Management,the Sub Staff of Administration, and the Archivist. The data were

  2. BioBenchmark Toyama 2012: an evaluation of the performance of triple stores on biological data.

    Science.gov (United States)

    Wu, Hongyan; Fujiwara, Toyofumi; Yamamoto, Yasunori; Bolleman, Jerven; Yamaguchi, Atsuko

    2014-01-01

    Biological databases vary enormously in size and data complexity, from small databases that contain a few million Resource Description Framework (RDF) triples to large databases that contain billions of triples. In this paper, we evaluate whether RDF native stores can be used to meet the needs of a biological database provider. Prior evaluations have used synthetic data with a limited database size. For example, the largest BSBM benchmark uses 1 billion synthetic e-commerce knowledge RDF triples on a single node. However, real world biological data differs from the simple synthetic data much. It is difficult to determine whether the synthetic e-commerce data is efficient enough to represent biological databases. Therefore, for this evaluation, we used five real data sets from biological databases. We evaluated five triple stores, 4store, Bigdata, Mulgara, Virtuoso, and OWLIM-SE, with five biological data sets, Cell Cycle Ontology, Allie, PDBj, UniProt, and DDBJ, ranging in size from approximately 10 million to 8 billion triples. For each database, we loaded all the data into our single node and prepared the database for use in a classical data warehouse scenario. Then, we ran a series of SPARQL queries against each endpoint and recorded the execution time and the accuracy of the query response. Our paper shows that with appropriate configuration Virtuoso and OWLIM-SE can satisfy the basic requirements to load and query biological data less than 8 billion or so on a single node, for the simultaneous access of 64 clients. OWLIM-SE performs best for databases with approximately 11 million triples; For data sets that contain 94 million and 590 million triples, OWLIM-SE and Virtuoso perform best. They do not show overwhelming advantage over each other; For data over 4 billion Virtuoso works best. 4store performs well on small data sets with limited features when the number of triples is less than 100 million, and our test shows its scalability is poor; Bigdata

  3. Triple immunofluorescence labeling of atherosclerotic plaque components in apoE/LDLR -/- mice.

    OpenAIRE

    Stefan Chłopicki; Andrzej Radziszewski; Grzegorz J Lis; Lukasz Mateuszuk; Jacek Jawień; Mariusz Gajda; Jan A Litwin

    2008-01-01

    This paper presents a simple and reliable method of triple immunofluorescence staining that allows simultaneous detection of various cell types present in atherosclerotic plaque of apolipoprotein E and LDL receptor-double knockout (apoE/LDLR -/-) mice. We used combined direct and indirect procedures applying commercially available primary antibodies raised in different species to detect smooth muscle cells (Cy3-conjugated mouse anti-smooth muscle actin, SMA), macrophages (rat anti-CD68) and T...

  4. Normalization for triple-target microarray experiments

    Directory of Open Access Journals (Sweden)

    Magniette Frederic

    2008-04-01

    Full Text Available Abstract Background Most microarray studies are made using labelling with one or two dyes which allows the hybridization of one or two samples on the same slide. In such experiments, the most frequently used dyes are Cy3 and Cy5. Recent improvements in the technology (dye-labelling, scanner and, image analysis allow hybridization up to four samples simultaneously. The two additional dyes are Alexa488 and Alexa494. The triple-target or four-target technology is very promising, since it allows more flexibility in the design of experiments, an increase in the statistical power when comparing gene expressions induced by different conditions and a scaled down number of slides. However, there have been few methods proposed for statistical analysis of such data. Moreover the lowess correction of the global dye effect is available for only two-color experiments, and even if its application can be derived, it does not allow simultaneous correction of the raw data. Results We propose a two-step normalization procedure for triple-target experiments. First the dye bleeding is evaluated and corrected if necessary. Then the signal in each channel is normalized using a generalized lowess procedure to correct a global dye bias. The normalization procedure is validated using triple-self experiments and by comparing the results of triple-target and two-color experiments. Although the focus is on triple-target microarrays, the proposed method can be used to normalize p differently labelled targets co-hybridized on a same array, for any value of p greater than 2. Conclusion The proposed normalization procedure is effective: the technical biases are reduced, the number of false positives is under control in the analysis of differentially expressed genes, and the triple-target experiments are more powerful than the corresponding two-color experiments. There is room for improving the microarray experiments by simultaneously hybridizing more than two samples.

  5. On Spectral Triples in Quantum Gravity I

    DEFF Research Database (Denmark)

    Aastrup, Johannes; M. Grimstrup, Jesper; Nest, Ryszard

    2009-01-01

    . The interaction between the Dirac operator and the algebra reproduces the Poisson structure of General Relativity. Moreover, the associated Hilbert space corresponds, up to a discrete symmetry group, to the Hilbert space of diffeomorphism invariant states known from Loop Quantum Gravity. Correspondingly......This paper establishes a link between Noncommutative Geometry and canonical quantum gravity. A semi-finite spectral triple over a space of connections is presented. The triple involves an algebra of holonomy loops and a Dirac type operator which resembles a global functional derivation operator...

  6. Triple mode filters with coaxial excitation

    NARCIS (Netherlands)

    Gerini, G.; Bustamante, F.D.; Guglielmi, M.

    2004-01-01

    In this paper we describe triple mode filters in a square waveguide with integrated coaxial input/output excitation. An important feature of the structure proposed is that it is easily amenable to an accurate full wave analysis. In addition to theory, a practical six pole filter with two

  7. Targeting EGFR in Triple Negative Breast Cancer

    OpenAIRE

    Naoto T. Ueno, Dongwei Zhang

    2011-01-01

    Our preliminary data show that erlotinib inhibits Triple-negative breast cancer (TNBC) in a xenograft model. However, inhibition of metastasis by erlotinib is accompanied by nonspecific effects because erlotinib can inhibit other kinases; thus, more direct targets that regulate TNBC metastasis need to be identified to improve its therapeutic efficacy.

  8. Targeting EGFR in Triple Negative Breast Cancer

    Directory of Open Access Journals (Sweden)

    Naoto T. Ueno, Dongwei Zhang

    2011-01-01

    Full Text Available Our preliminary data show that erlotinib inhibits Triple-negative breast cancer (TNBC in a xenograft model. However, inhibition of metastasis by erlotinib is accompanied by nonspecific effects because erlotinib can inhibit other kinases; thus, more direct targets that regulate TNBC metastasis need to be identified to improve its therapeutic efficacy.

  9. Revised Reynolds Stress and Triple Product Models

    Science.gov (United States)

    Olsen, Michael E.; Lillard, Randolph P.

    2017-01-01

    Revised versions of Lag methodology Reynolds-stress and triple product models are applied to accepted test cases to assess the improvement, or lack thereof, in the prediction capability of the models. The Bachalo-Johnson bump flow is shown as an example for this abstract submission.

  10. Genetics Home Reference: triple A syndrome

    Science.gov (United States)

    ... de Laet MH, Chaouachi B, Bakiri F, Brottier P, Cattolico L, Penet C, Bégeot M, Naville D, Nicolino M, Chaussain JL, Weissenbach J, Munnich A, Lyonnet S. Mutant WD-repeat protein in triple-A syndrome. Nat Genet. 2000 Nov;26(3): ...

  11. Triple-axis spectrometer DruechaL

    Energy Technology Data Exchange (ETDEWEB)

    Buehrer, W.; Keller, P. [Lab. for Neutron Scattering ETH Zurich, Zurich (Switzerland) and Paul Scherrer Institute, Villigen (Switzerland)

    1996-11-01

    DruechaL is a triple-axis spectrometer located at a cold guide. The characteristics of guide and instrument allow the use of a broad spectral range of neutrons. The resolution in momentum and energy transfer can be tuned to match the experimental requirements by using either collimators or focusing systems (monochromator, antitrumpet, analyser). (author) figs., tabs., refs.

  12. Clinicopathological comparison of triple negative breast cancers ...

    African Journals Online (AJOL)

    Key words: Basal subtype, estrogen receptor, hormone receptors, human epidermal growth factor receptor‑2/neu, progesterone receptor, triple negative. Date of Acceptance: 10‑Nov‑2014. Introduction. Breast cancer is by far the most frequent cancer among women worldwide with an estimated 1.38 million new cases of ...

  13. PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE STUDENT TEAM ACHIEVMENT DIVISION (STAD UNTUK MENINGKATKAN AKTIVITAS DAN HASIL BELAJAR PADA KOMPETENSI DASAR MEMELIHARA PERALATAN KANTOR SISWA KELAS X.3 AP SMK KRISTEN SALATIGA

    Directory of Open Access Journals (Sweden)

    Septian Dwi Prasetyo

    2013-01-01

    Full Text Available Tujuannya adalah untuk mengetahui apakah penerapan model pembelajaran kooperatif tipe Student Team Achievment Division (STAD dapat meningkatkan aktivitas dan hasil belajar memelihara peralatan kantor sisiwa kelas X.3 AP SMK Kristen Salatiga. Penelitian ini menggunakan desain PTK. Subjek penelitiannya adalah siswa kelas X.3 AP SMK Kristen Salatiga. Penelitian ini terdiri dari 2 siklus, tiap siklus terdiri dari perencanaan, tindakan, observasi, dan refleksi. Data diperoleh dengan instrumen tes berupa soal pilihan ganda, dan instrumen nontes berupa lembar observasi. Analisis data dilakukan dengan teknik analisis deskriptif persentase. Hasil analisis data penelitian dari prasiklus, siklus I dan II mengalami peningkatan hasil belajar secara klasikal 46,88%, 62,50%, dan 90,63%, jadi ada kenaikan 15,62 % pada siklus I dan 28,13% pada siklus II. Sedangkan untuk rata-rata aktivitas siswa 63,63% pada siklus I dan 81,13% pada siklus II. Berdasarkan hasil penelitian di atas dapat disimpulkan bahwa penerapan model pembelajaran kooperatif tipe Student Team Achievment Division (STAD dapat meningkatkan aktivitas dan hasil belajar memelihara peralatan kantor siswa kelas X.3 AP SMK Kristen Salatiga, dengan keterlibatan siswa secara aktif selama proses pembelajaran berlangsung. The goal is to determine whether the application of Student Team Achievment Division (STAD cooperative learning model to improve the activity and learning outcomes maintain office equipment AP class X.3 students of SMK Christian Salatiga. The design of this study PTK. Research subject is a class X.3 student of SMK Christian AP Salatiga. The study consisted of two cycles, each cycle consisting of planning, action, observation, and reflection. Date obtained with the test instrument in the form of multiple choice questions, and a nontest instruments observation sheet. Date were analyzed by descriptive analysis techniques percentage. The results of the analysis of research data prasiklus, Cycle

  14. Absolute migration and the evolution of the Rodriguez Triple ...

    African Journals Online (AJOL)

    Masalu-Absolute migration and the evolution of the Rodriguez Triple Junction consequence of the evolution of the Indian Ocean Triple. Junction. Geophys. J. Royal Astro. Soc. 64: 587-604. Tapscott CR, Patriat P, Fisher RL, Sclater JG, Hoskins H and Parsons B. 1980 The Indian Ocean Triple Junction. J. Geophys. Res. 85:.

  15. Semiclassical model of triple photons generation in optical fibers

    Science.gov (United States)

    Richard, S.; Bencheikh, K.; Boulanger, B.; Levenson, J. A.

    2011-08-01

    In this Letter we study spontaneous generation of triple photon states in optical fibers by third order spontaneous downconversion. Using a semiclassical approach we derive an explicit expression for the triple photons generation efficiency as a function of fiber parameters. We show that optical fibers with well suited index profiles and standard outer diameters could be the key component of future triple photons sources.

  16. Irreducible almost simple subgroups of classical algebraic groups

    CERN Document Server

    Burness, Timothy C; Marion, Claude; Testerman, Donna M

    2015-01-01

    Let G be a simple classical algebraic group over an algebraically closed field K of characteristic p\\geq 0 with natural module W. Let H be a closed subgroup of G and let V be a nontrivial p-restricted irreducible tensor indecomposable rational KG-module such that the restriction of V to H is irreducible. In this paper the authors classify the triples (G,H,V) of this form, where V \

  17. Double Planet Meets Triple Star

    Science.gov (United States)

    2002-08-01

    atmosphere, a large campaign involving more than twenty scientists and engineers from the Paris Observatory and associated institutions [1] was organized to observe the July 20, 2002, event involving an occultation of a star of visual magnitude 11 (i.e., about 100 times fainter than what can be perceived with then unaided eye), referred to as "P126" in McDonald and Elliot's catalogue. In May 2002, preparatory observations showed that star to be double, with the brighter component of the system ( "P126 A" ) being likely to be occulted by Pluto, as seen from South America. However, because of the duplicity, the predictions of exactly where the shadow of Pluto would sweep the ground were uncertain by about 0.1 arcsec in the sky, corresponding to more than 2000 km on the ground. The NACO images ESO PR Photo 21b/02 ESO PR Photo 21b/02 [Preview - JPEG: 400 x 469 pix - 47k] [Normal - JPEG: 800 x 937 pix - 208k] ESO PR Photo 21c/02 ESO PR Photo 21c/02 [Preview - JPEG: 400 x 467 pix - 53k] [Normal - JPEG: 800 x 933 pix - 232k] Caption : PR Photo 21b/02 shows one of the images obtained with the NAOS-CONICA (NACO) adaptive optics (AO) camera mounted on the ESO VLT 8.2-m YEPUN telescope at the Paranal Observatory in connection with a stellar occultation by Pluto on July 20, 2002. The star was found to be triple - the three components (A, B and C), as well as Pluto and its moon, Charon, are indicated in PR Photo 21c/02 for easy orientation. The images are based on data available from the NACO data webpage. See the text for details. In the end, the close approach (an "appulse" in astronomical terminology) of Pluto and P126 A was indeed observed from various sites in South America, with several mobile telescopes and also including major facilities at the ESO La Silla and Paranal Observatories. In particular, unique and very sharp images were obtained with the NAOS-CONICA (NACO) adaptive optics (AO) camera mounted on the ESO VLT 8.2-m YEPUN telescope . One of the NACO images is shown in PR

  18. Triple Achilles Tendon Rupture: Case Report.

    Science.gov (United States)

    Saxena, Amol; Hofer, Deann

    2017-11-16

    We present a case report with 1-year follow-up data of a 57-year-old male soccer referee who had sustained an acute triple Achilles tendon rupture injury during a game. His triple Achilles tendon rupture consisted of a rupture of the proximal watershed region, a rupture of the main body (mid-watershed area), and an avulsion-type rupture of insertional calcific tendinosis. The patient was treated surgically with primary repair of the tendon, including tenodesis with anchors. Postoperative treatment included non-weightbearing for 4 weeks and protected weightbearing until 10 weeks postoperative, followed by formal physical therapy, which incorporated an "antigravity" treadmill. The patient was able to return to full activity after 26 weeks, including running and refereeing, without limitations. Copyright © 2017 The American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.

  19. On split Lie triple systems II

    Indian Academy of Sciences (India)

    In the present paper we extend these results to arbitrary split Lie triple systems with no restrictions on their 0-root spaces. Author Affiliations. Antonio J Calderón Martín1 M Forero Piulestán1. Departamento de Matemáticas, Universidad de Cádiz, 11510 Puerto Real, Cádiz, Spain. Dates. Manuscript received: 24 June 2009 ...

  20. Triple plasmon resonance of bimetal nanoshell

    Energy Technology Data Exchange (ETDEWEB)

    Shirzaditabar, Farzad [Department of Physics, Razi University, Kermanshah (Iran, Islamic Republic of); Saliminasab, Maryam, E-mail: m.saliminasab@yahoo.com [Young Researchers Club, Kermanshah Branch, Islamic Azad University, Kermanshah (Iran, Islamic Republic of); Arghavani Nia, Borhan [Department of Physics, Kermanshah Branch, Islamic Azad University, Kermanshah (Iran, Islamic Republic of)

    2014-07-15

    In this paper, light absorption spectra properties of a bimetal multilayer nanoshell based on quasi-static approach are investigated. Comparing with silver-dielectric-silver and silver-dielectric-gold nanoshells, gold-dielectric-silver nanoshells have three intense and separated plasmon peaks which are more suitable for multiplex biosensing. Calculations show that relatively small thickness of outer silver shell and large dielectric constant of middle dielectric layer of gold-dielectric-silver nanoshell are suitable to obtain the triple plasmon resonance.

  1. Features of triple-negative breast cancer

    OpenAIRE

    Plasilova, Magdalena L.; Hayse, Brandon; Killelea, Brigid K.; Horowitz, Nina R; Chagpar, Anees B.; Donald R. Lannin

    2016-01-01

    Abstract The aim of this study was to determine the features of triple-negative breast cancer (TNBC) using a large national database. TNBC is known to be an aggressive subtype, but national epidemiologic data are sparse. All patients with invasive breast cancer and known molecular subtype diagnosed in 2010 to 2011 were identified from the National Cancer Data Base (NCDB). Patients with and without TNBC were compared with respect to their sociodemographic and clinicopathologic features. TNBC w...

  2. Triple Negative Breast Cancer – An Overview

    OpenAIRE

    Aysola, Kartik; Desai, Akshata; Welch, Crystal; Xu, Jingyao; QIN, YUNLONG; REDDY, VAISHALI; Matthews,Roland; Owens, Charlotte; Okoli, Joel; Beech, Derrick J; Piyathilake, Chandrika J.; Reddy, Shyam P; Rao, Veena N.

    2013-01-01

    Triple Negative Breast Cancer (TNBC) is a heterogeneous disease that based on immunohistochemistry (IHC) is estrogen receptor (ER) negative, progesterone receptor (PR) negative and human epidermal growth factor receptor 2 (HER2) negative. TNBC is typically observed in young AA women and Hispanic women who carry a mutation in the BRCA1 gene. TNBC is characterized by a distinct molecular profile, aggressive nature and lack of targeted therapies. The purpose of this article is to review the curr...

  3. Adjuvant Therapy of Triple Negative Breast Cancer

    OpenAIRE

    Perez, Edith A.; Moreno-Aspitia, Alvaro; Thompson, E. Aubrey; Andorfer, Cathy A

    2010-01-01

    Patients with the triple negative subtype of breast cancer have an overall poor outcome, with earlier relapses, distinct patterns of metastases, and lack of specific targets for treatment selection. Classification of these tumors has begun to be modified by inclusion of immunohistochemistry for various markers, and gene profiling, to further characterize this subtype of breast cancer, may aid in the identification of new targeted therapies. Anthracyclines and taxanes remain the standard of ca...

  4. Triple Teeth: Report of an Unusual Case

    Directory of Open Access Journals (Sweden)

    Prashant Babaji

    2012-01-01

    Full Text Available Fusion or synodontia is a union of two or more than two developing teeth. Commonly fusion occurs between teeth of the same dentition, mixed dentition, or between normal and supernumerary teeth. Fused primary teeth present with several clinical problems like caries, periodontal problem, arch asymmetry, delayed eruption, ectopic eruption of succedaneous teeth, aesthetic, and other complications. This paper presents a rare and unusual case of triple teeth in mandibular primary dentition.

  5. Triple Teeth: Report of an Unusual Case

    OpenAIRE

    Prashant Babaji; Prasanth, M. A.; Ajith R. Gowda; Soumya Ajith; Henston D'Souza; K. P. Ashok

    2012-01-01

    Fusion or synodontia is a union of two or more than two developing teeth. Commonly fusion occurs between teeth of the same dentition, mixed dentition, or between normal and supernumerary teeth. Fused primary teeth present with several clinical problems like caries, periodontal problem, arch asymmetry, delayed eruption, ectopic eruption of succedaneous teeth, aesthetic, and other complications. This paper presents a rare and unusual case of triple teeth in mandibular primary dentition.

  6. Triple teeth: report of an unusual case.

    Science.gov (United States)

    Babaji, Prashant; Prasanth, M A; Gowda, Ajith R; Ajith, Soumya; D'Souza, Henston; Ashok, K P

    2012-01-01

    Fusion or synodontia is a union of two or more than two developing teeth. Commonly fusion occurs between teeth of the same dentition, mixed dentition, or between normal and supernumerary teeth. Fused primary teeth present with several clinical problems like caries, periodontal problem, arch asymmetry, delayed eruption, ectopic eruption of succedaneous teeth, aesthetic, and other complications. This paper presents a rare and unusual case of triple teeth in mandibular primary dentition.

  7. Triple collinear emissions in parton showers

    Energy Technology Data Exchange (ETDEWEB)

    Höche, Stefan [SLAC; Prestel, Stefan [Fermilab

    2017-05-01

    A framework to include triple collinear splitting functions into parton showers is presented, and the implementation of flavor-changing NLO splitting kernels is discussed as a first application. The correspondence between the Monte-Carlo integration and the analytic computation of NLO DGLAP evolution kernels is made explicit for both timelike and spacelike parton evolution. Numerical simulation results are obtained with two independent implementations of the new algorithm, using the two independent event generation frameworks Pythia and Sherpa.

  8. Expression and prognostic value of estrogen receptor β in patients with triple-negative and triple-positive breast cancer.

    Science.gov (United States)

    Guo, Liying; Zhu, Qianwen; Aisimutuola, Mulati; Yilamu, Dilimina; Liu, Sha; Jakulin, Adina

    2015-06-01

    The aim of the present study was to investigate the expression of estrogen receptor β (ERβ) in triple-negative and triple-positive breast cancer patients, and evaluate its utility as a prognostic factor. Between January 2000 and December 2010, primary tumor tissue samples were collected from 234 subjects, including 107 triple-negative and 127 triple-positive breast cancer patients. The samples were embedded in paraffin and immunohistochemical staining was conducted to determine the expression levels of ERβ. The Kaplan-Meier method was used to analyze patient survival rates. ERβ expression was observed in 38/107 patients (35.5%) with triple-negative breast cancer and 63/127 patients (49.6%) with triple-positive breast cancer. The ERβ expression rate was significantly decreased in the patients with triple-negative breast cancer, as compared with those with triple-positive breast cancer (P=0.03). Analysis of the survival rates indicated that patients with triple-negative breast cancer and positive ERβ expression exhibited poor disease progression-free survival (DFS) compared with those with negative ERβ expression (P=0.021). However, no statistically significant difference was observed in the DFS between the triple-positive breast cancer patients with positive and negative ERβ expression. Therefore, the expression of ERβ varies between triple-negative and triple-positive breast cancer patients. In addition, positive expression of ERβ indicates a poor prognosis in triple-negative breast cancer patients; however, this is not the case for triple-positive breast cancer patients.

  9. Triple dye plus rubbing alcohol versus triple dye alone for umbilical cord care.

    Science.gov (United States)

    Suliman, Alawia K; Watts, Heidi; Beiler, Jessica; King, Tonya S; Khan, Sana; Carnuccio, Marybeth; Paul, Ian M

    2010-01-01

    Current practices for umbilical cord care vary across centers, but the evidence regarding these practices and their impact on cord separation, complications, and health care use are limited. The objective of this study was to compare the effect of triple dye alone (brilliant green, crystal violet, and proflavine hemisulfate) versus triple dye plus rubbing alcohol (isopropyl alcohol) twice daily on time to umbilical cord separation, complications, and health care use. For the 90 newborns who completed the study, there were no significant differences between treatment groups for time to cord separation, cord-related morbidities, or cord-related urgent care. Based on these study results, there does not appear to be significant benefit to the addition of twice daily applications of rubbing alcohol to neonatal umbilical cords following triple dye treatment after birth.

  10. Measurement of grain boundary triple line energy in copper

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, B. [Institut fuer Metallkunde und Metallphysik, RWTH Aachen University, 52056 Aachen (Germany); Verhasselt, J.Ch. [Sparing Roehl Henseler, Rethelstr. 123, 40237 Duesseldorf (Germany); Shvindlerman, L.S. [Institut fuer Metallkunde und Metallphysik, RWTH Aachen University, 52056 Aachen (Germany)] [Institute of Solid State Physics, Russian Academy of Sciences, Chernogolovka, Moscow District 142432 (Russian Federation)] [State Technological University, Moscow Institute of Steel and Alloys (Russian Federation); Gottstein, G., E-mail: Gottstein@imm.rwth-aachen.de [Institut fuer Metallkunde und Metallphysik, RWTH Aachen University, 52056 Aachen (Germany)

    2010-10-15

    Recent studies have demonstrated that grain boundary triple junctions are crystal defects with specific thermodynamic and kinetic properties. In this study we address the energy of triple lines. Previously, a geometrical model was proposed to determine the grain boundary line tension. The current study introduces a thermodynamically correct approach which allows direct and precise measurement of the triple line energy. The experimental technique utilizes the measurement of the surface topography of a crystal in the vicinity of a triple junction by atomic force microscopy. The grain boundary triple line tension {gamma}{sub TP}{sup l} of a random triple line in a copper tricrystal was measured to be 6.3 {+-} 2.8 x 10{sup -9} J m{sup -1}.

  11. Targeting Prolyl Peptidases in Triple-Negative Breast Cancer

    Science.gov (United States)

    2017-02-01

    AWARD NUMBER: W81XWH-16-1-0025 TITLE: Targeting Prolyl Peptidases in Triple-Negative Breast Cancer PRINCIPAL INVESTIGATOR: Carl G. Maki, PhD...SUBTITLE Targeting Prolyl Peptidases in Triple-Negative Breast Cancer 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-16-1-0025 5c. PROGRAM ELEMENT NUMBER 6...ABSTRACT Triple negative breast cancer (TNBC) is an aggressive sub-type with limited treatment options and poor prognosis. The most life-threatening

  12. Recovery by triple junction motion in heavily deformed metals

    DEFF Research Database (Denmark)

    Yu, Tianbo; Hansen, Niels; Huang, Xiaoxu

    2015-01-01

    is briefly considered, whereas recovery in samples deformed to much higher strains is discussed in more detail. An example is Al, where a new and important recovery mechanism is triple junction motion, which can remove thin lamellae and consequently increase the thickness of neighbouring lamellae...... controlling the rate of recovery by triple junction motion. Operation of triple junction motion in other heavily deformed metals, such as Ni and Cu, is also briefly discussed....

  13. Triple tooth in primary dentition: A proposed classification

    Directory of Open Access Journals (Sweden)

    Gaddam Shilpa

    2013-01-01

    Full Text Available Triple teeth may result from fusion, gemination or concrescence causing transient esthetic and functional problems in primary dentition and retardation or alteration of development and eruption of permanent successors. We report an unusual case of a boy aged five with fusion among maxillary left primary central incisor, lateral incisor and a supernumerary tooth concomitant with agenesis of permanent lateral incisor. A review of literature on triple tooth was done along with a proposed classification of the triple teeth.

  14. Equivariant spectral triples on the quantum SU(2) group

    OpenAIRE

    Chakraborty, Partha Sarathi; Pal, Arupkumar

    2002-01-01

    We characterize all equivariant odd spectral triples for the quantum SU(2) group acting on its L_2-space and having a nontrivial Chern character. It is shown that the dimension of an equivariant spectral triple is at least three, and given any element of the K-homology group of SU_q(2), there is an equivariant odd spectral triple of dimension 3 inducing that element. The method employed to get equivariant spectral triples in the quantum case is then used for classical SU(2), and we prove that...

  15. Simple Machine Junk Cars

    Science.gov (United States)

    Herald, Christine

    2010-01-01

    During the month of May, the author's eighth-grade physical science students study the six simple machines through hands-on activities, reading assignments, videos, and notes. At the end of the month, they can easily identify the six types of simple machine: inclined plane, wheel and axle, pulley, screw, wedge, and lever. To conclude this unit,…

  16. Fractura triple del complejo suspensorio del hombro

    OpenAIRE

    Eraclio Delgado Rifá; Héctor Gabriel Díaz Carrillo; Manuel Miranda Digón

    2015-01-01

    El complejo suspensorio del hombro es una estructura sumamente importante, compuesta por un anillo de huesos y tejidos blandos. Las lesiones aisladas de este complejo anatómico son frecuentes y no afectan su estabilidad. La interrupción doble conduce a la inestabilidad de esta estructura y usualmente requiere tratamiento quirúrgico. La triple interrupción, por su parte, es sumamente rara y es encontrada en casos de trauma de alta energía a menudo en asociación con otras lesiones. Se presenta ...

  17. Genetic Susceptibility to Triple Negative Breast Cancer

    OpenAIRE

    Stevens, Kristen N.; Vachon, Celine M.; Couch, Fergus J.

    2013-01-01

    Triple negative breast cancers (TNBC), defined by the absence of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 expression, account for 12-24% of all breast cancers. TNBC is associated with early recurrence of disease and poor outcome. Germline mutations in the BRCA1 and BRCA2 breast cancer susceptibility genes have been associated with up to 15% of TNBC, and TNBC accounts for 70% of breast tumors arising in BRCA1 mutation carriers and 16-23% of breast ...

  18. Triple helix interactions for eco-innovation

    DEFF Research Database (Denmark)

    Hermann, Roberto Rivas; Riisgaard, Henrik; Remmen, Arne

    . Overall, the research found that the Panamanian national innovation system facilitates eco-innovation by: providing research and development, building competence and financing of innovation processes. The “green maritime route” is an example of institutional eco-innovation promoted by the Panama Canal...... Authority with insights from consultants, universities and donnor agencies. The proximity of the science park to the canal, has hitherto not yielded with the creation of a “green cluster”, which could be a precedent to promote eco-innovations. These findings suggest that, Triple Helix interactions...

  19. Triple Pelvic Osteotomy and Double Pelvic Osteotomy.

    Science.gov (United States)

    Guevara, Francisco; Franklin, Samuel P

    2017-07-01

    Triple and double pelvic osteotomy (TPO, DPO) are performed with the goal of increasing acetabular ventro-version, increasing femoral head coverage, and decreasing femoral head subluxation. Since the first descriptions of TPO, there have been modifications in technique, most notably omission of the ischial osteotomy for DPO, and improvements in the implants, including availability of locking TPO/DPO bone plates. Associated complication rates seem to have declined accordingly. The most salient questions regarding these procedures remain what selection criteria should be used to identify candidates and whether halting or preventing osteoarthritis is necessary to consider these surgeries clinically beneficial. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. Teaching metathesis "simple" stereochemistry.

    Science.gov (United States)

    Fürstner, Alois

    2013-09-20

    Applications of metal-catalyzed olefin metathesis reactions manifested dramatic growth during the late 20th and early 21st centuries, culminating in the 2005 Nobel Prize awarded to three of the pioneers. The standard catalysts developed during that time frame and their descendants have profoundly changed the mindset of the synthetic community, even though they do not provide a handle to control selectivity issues as fundamental as the E/Z geometry of the newly formed double bond. With yet another generation of catalysts in the making that are far superior in this regard, a new wave seems to be building up that is expected to have enormous impact, too. The current state of the art is critically assessed, as are possible alternatives such as the metathesis of triple bonds followed by stereoselective semi-reduction.

  1. [Triple-Endobutton plates for the treatment of rockwood type III to V acromioclavicular joint dislocation].

    Science.gov (United States)

    Yin, Ji-Heng

    2014-01-01

    To evaluate the clinical results of Triple-Endobutton plates for the treatment of Rockwood type III to V acromioclavicular joint dislocation. From March 2008 to June 2010,28 patients with Rockwood type II to V acromioclavicular joint dislocations were treated with Triple-Endobutton plates. There were 18 males and 10 females,ranging in age from 20 to 60 years old (averaged 38 years old). Twenty patients had dislocations in the left and 8 patients had dislocations in the right. All the patients had close injury. The Constant criterion was used to evaluate shoulder joint function. All the patients were followed up,and the duration ranged from 18 to 24 months,with an average of 20 months. All the patients got good shoulder joint function,and no re-dislocation and pain occurred. The X-ray showed all acromioclavicular joints got good reduction. According to Constant criterion,preoperative score was 25.4 +/- 2.0, postoperative scores were 65.9 +/- 3.0, 87.2 +/- 3.2 and 95.7+/- 1.6 at 1 month,3 months and 6 months separately. Treatment of Rockwood type III to V acromioclavicular joint dislocation with Triple-Endobutton plates has satisfactory clinical outcome, simple operation, few complications, without secondary operation and early functional exercise postoperatively.

  2. Cross- and triple-ratios of human body parts during development.

    Science.gov (United States)

    Lundh, Torbjörn; Udagawa, Jun; Hänel, Sven-Erik; Otani, Hiroki

    2011-08-01

    Recently developed landmark-based geometric morphometry has been used to depict the morphological development of organisms. In geometry, four landmarks can be mapped to any other four by Möbius transformations, if the cross-ratio of the landmarks is invariant and vice versa. To geometrically analyze the morphological development of the human body, we examined the cross-ratio of three consecutive body parts that are segmented by four landmarks in their configuration. Moreover, we introduced the triple-ratio of five landmarks that segments four consecutive parts (e.g., the shoulder, upper arm, forearm, and hand) and examined their growth patterns. The cross- and triple-ratios of the upper limb and shoulder girdle in fetuses were constant when biomechanical landmarks were used, although the cross-ratio of the upper limb varied when anatomical landmarks were used. The cross-ratios of the lower limbs, trunk, and pelvic girdles in fetuses differed from their corresponding cross-ratios in adults. These results suggest Möbius growth in the fetal upper limb and shoulder girdle but not in the other body parts examined. However, the growth balance of the three contiguous body parts was represented by the developmental change in the cross-ratio. Therefore, the cross- and triple-ratios may be applicable for simple but significant assessments of growth balance or proportion of the body parts. Copyright © 2011 Wiley-Liss, Inc.

  3. Triangle anomaly in triple-Regge limits

    Science.gov (United States)

    White, Alan R.

    2001-01-01

    Reggeized gluon interactions due to a single quark loop are studied in the full triple-Regge limit and in closely related helicity-flip helicity-pole limits. Triangle diagram Reggeon interactions are generated that include local axial-vector effective vertices. It is shown that the massless quark triangle anomaly is present as a chirality-violating infrared divergence in the interactions generated by maximally nonplanar Feynman diagrams. An asymptotic dispersion relation formalism is developed which provides a systematic counting of anomaly contributions. The asymptotic amplitude is written as a sum over dispersion integrals of triple discontinuities, one set of which is unphysical and can produce chirality transitions. The physical-region anomaly appears in the generalized real parts, determined by multi-Regge theory, of the unphysical discontinuities. The amplitudes satisfy a signature conservation rule that implies color parity is not conserved by vertices containing the anomaly. In the scattering of elementary quarks or gluons the signature and color parity of the exchanged Reggeon states are such that the anomaly cancels. At lowest order, it cancels in individual diagrams after the transverse momentum integrations are performed.

  4. VERITAS: Versatile Triple-Axis Spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sung Il

    2006-04-15

    Korea Atomic Energy Research Institute is planning to build a cold neutron triple-axis spectrometer at HANARO, the 30 MW research reactor. The spectrometer is expected to be completed in 2008 with the following configuration from the upstream to the downstream. Guide Supermirror m = 2, In-pile Straight Section, {approx} 5 m Curved Guide, {approx} 26 m w/ R 1500 m Straight Guide before the Instrument, {approx} 40 m Filters PG and Be Neutron Velocity Selector (Future) Monochromators Vertically Focusing Monochromators PG(002) and Heusler(111) Doubly Focusing Monochromators (Future) Monochromator-Sample Distance 2 m Collimation C1 Soller Collimators, 20', 40' 80'Beam Height at the Sample Table 1.5 m Sample-Analyzer Distance 1.0 m Collimation C2 Soller Collimators, 20', 40', 80' Radial Collimator Analyzers Horizontally Focusing Analyzers w/ Fixed Vertical Focusing PG(002) and Heusler(111) Analyzer-Detector Distance 0.5 m Detectors 5 cm Tube Detector 25 cm wide Position Sensitive Detector Once completed, the neutron flux at sample is expected to surpass that of SPINS at NCNR, making this instrument one of the most powerful 2nd generation cold neutron triple-axis spectrometers in the world.

  5. Robust Modeling of Stellar Triples in PHOEBE

    Science.gov (United States)

    Conroy, Kyle E.; Prsa, Andrej; Horvat, Martin; Stassun, Keivan G.

    2017-01-01

    The number of known mutually-eclipsing stellar triple and multiple systems has increased greatly during the Kepler era. These systems provide significant opportunities to both determine fundamental stellar parameters of benchmark systems to unprecedented precision as well as to study the dynamical interaction and formation mechanisms of stellar and planetary systems. Modeling these systems to their full potential, however, has not been feasible until recently. Most existing available codes are restricted to the two-body binary case and those that do provide N-body support for more components make sacrifices in precision by assuming no stellar surface distortion. We have completely redesigned and rewritten the PHOEBE binary modeling code to incorporate support for triple and higher-order systems while also robustly modeling data with Kepler precision. Here we present our approach, demonstrate several test cases based on real data, and discuss the current status of PHOEBE's support for modeling these types of systems. PHOEBE is funded in part by NSF grant #1517474.

  6. The prognostic value of the neoadjuvant response index in triple-negative breast cancer : validation and comparison with pathological complete response as outcome measure

    NARCIS (Netherlands)

    Jebbink, M.; van Werkhoven, E.; Mandjes, I. A. M.; Wesseling, J.; Lips, E. H.; Peeters, M. -J. T. D. F. Vrancken; Loo, C. E.; Sonke, G. S.; Linn, S. C.; Falo Zamora, C.; Rodenhuis, S.

    The Neoadjuvant response index (NRI) has been proposed as a simple measure of downstaging by neoadjuvant treatment in breast cancer. It was previously found to predict recurrence-free survival (RFS) in triple-negative (TN) breast cancer. It was at least as accurate as the standard binary system, the

  7. BROWN DWARF BINARIES FROM DISINTEGRATING TRIPLE SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    Reipurth, Bo [Institute for Astronomy and NASA Astrobiology Institute University of Hawaii, 640 N. Aohoku Place, Hilo, HI 96720 (United States); Mikkola, Seppo, E-mail: reipurth@ifa.hawaii.edu, E-mail: Seppo.Mikkola@utu.fi [Tuorla Observatory, University of Turku, Väisäläntie 20, Piikkiö (Finland)

    2015-04-15

    Binaries in which both components are brown dwarfs (BDs) are being discovered at an increasing rate, and their properties may hold clues to their origin. We have carried out 200,000 N-body simulations of three identical stellar embryos with masses drawn from a Chabrier IMF and embedded in a molecular core. The bodies are initially non-hierarchical and undergo chaotic motions within the cloud core, while accreting using Bondi–Hoyle accretion. The coupling of dynamics and accretion often leads to one or two dominant bodies controlling the center of the cloud core, while banishing the other(s) to the lower-density outskirts, leading to stunted growth. Eventually each system transforms either to a bound hierarchical configuration or breaks apart into separate single and binary components. The orbital motion is followed for 100 Myr. In order to illustrate 200,000 end-states of such dynamical evolution with accretion, we introduce the “triple diagnostic diagram,” which plots two dimensionless numbers against each other, representing the binary mass ratio and the mass ratio of the third body to the total system mass. Numerous freefloating BD binaries are formed in these simulations, and statistical properties are derived. The separation distribution function is in good correspondence with observations, showing a steep rise at close separations, peaking around 13 AU and declining more gently, reaching zero at separations greater than 200 AU. Unresolved BD triple systems may appear as wider BD binaries. Mass ratios are strongly peaked toward unity, as observed, but this is partially due to the initial assumptions. Eccentricities gradually increase toward higher values, due to the lack of viscous interactions in the simulations, which would both shrink the orbits and decrease their eccentricities. Most newborn triple systems are unstable and while there are 9209 ejected BD binaries at 1 Myr, corresponding to about 4% of the 200,000 simulations, this number has grown to

  8. Triple Play Service and IPTV Services Offered within it

    Directory of Open Access Journals (Sweden)

    Dagmar Pajdusakova

    2008-01-01

    Full Text Available This paper deals with Triple Play multimedia service and figures its architecture. Triple Play offers voice, video and data services together in one customer connection. There is offered IPTV (Internet Protocol Television service within this service, where we can include also Video on Demand service and other different additional services. In the paper is described classification of Video on Demand services.

  9. Triple procedure: cataract extraction, intraocular lens implantation, and corneal graft.

    Science.gov (United States)

    Oie, Yoshinori; Nishida, Kohji

    2017-01-01

    Corneal triple procedures consist of combined keratoplasty surgery and cataract surgery. Currently, anterior lamellar keratoplasty, endothelial keratoplasty, and conventional penetrating keratoplasty, are very often simultaneously performed with cataract surgery. The present article reviews the recent advances and current developments in corneal triple procedures. Many new findings have been reported. Core vitrectomy before host trephination and retroillumination during continuous curvilinear capsulorhexis has enabled us to perform penetrating keratoplasty triple procedures more safely. Type-1 big-bubble, baring Dua's layer, facilitates well tolerated anterior lamellar triple keratoplasty without Descemet membrane perforation. Descemet membrane endothelial keratoplasty triple procedure can provide excellent expected postoperative refraction. New techniques, including manual medium incision cataract surgery or glued intrascleral fixation of the intraocular lens with pupilloplasty, can be used for endothelial keratoplasty triple procedure, and frequent topical steroid administration can contribute to the reduction of postoperative cystoid macular edema. Recent technical advancements could contribute to safer and more effective corneal triple procedures. Triple surgery combined with novel procedures, including regenerative medicine and bioengineered corneal transplantation, will be performed in the near future.

  10. Unexpected Hydration of a Triple Bond During DNA Synthesis

    DEFF Research Database (Denmark)

    Fatthalla, Maha I.; Pedersen, Erik B.

    2016-01-01

    acidic conditions, polarizes the triple bond in the intercalator and this makes hydration of the triple bond possible during the DNA synthesis and an oligonucleotide with 1-(indol-3-yl)-2-(pyren-1-yl)ethanone as the intercalator is formed. Insertion of the unhydrated and hydrated linker systems gave...

  11. Independent sets in asteroidal triple-free graphs

    NARCIS (Netherlands)

    Broersma, Haitze J.; Kloks, Ton; Kloks, A.J.J.; Kratsch, Dieter; Müller, Haiko

    1997-01-01

    An asteroidal triple is a set of three vertices such that there is a path between any pair of them avoiding the closed neighborhood of the third. A graph is called AT-free if it does not have an asteroidal triple. We show that there is an O(n 2 · (¯m+1)) time algorithm to compute the maximum

  12. December2004 Results of Triple Arthrodesis in Uganda.

    African Journals Online (AJOL)

    user

    2004-12-02

    Dec 2, 2004 ... poliomyelitis and congenital clubfoot. Table 1 shows the triple arthrodesis grading in the 42 feet. Table 2 compares the results of surgery in different age groups at operation. There was no statistically no difference in outcome of triple arthrodesis in the three age groups (p Value = 0.14). There was no sex ...

  13. Construction and evaluation of a novel triple cell epitopebased ...

    African Journals Online (AJOL)

    Purpose: To construct a novel triple cell epitope-based polypeptide vaccine against cow mastitis induced by Staphylococcus aureus, Escherichia coli and Streptococcus and to reduce the use of antibiotics. Methods: Based on bioinformatics approach, a novel triple epitope-based polypeptide (CM-TEP) was designed and ...

  14. December2004 Results of Triple Arthrodesis in Uganda.

    African Journals Online (AJOL)

    user

    2004-12-02

    Dec 2, 2004 ... received inadequate treatment. Introduction. Triple arthrodesis, first described by Hoke and later by Dunn is regarded as a good salvage procedure to correct deformities and relieve pain of the foot 1,2, 5,6. Many surgeons believe that triple arthrodesis in children should be deferred until the age of 12 years, ...

  15. Absolute migration and the evolution of the Rodriguez triple junction ...

    African Journals Online (AJOL)

    The Rodriguez Triple Junction (RTJ) is a junction connecting three mid-ocean ridges in the Indian Ocean: the Southwest Indian Ridge (SWIR), the Central Indian Ridge (CIR) and the Southeast Indian Ridge (SEIR). The evolution of the RTJ has been studied extensively for the past 10 Ma and the triple junction is believed to ...

  16. Does Lactation Mitigate Triple Negative/Basal Breast Cancer Progression

    Science.gov (United States)

    2013-11-01

    Award Number: W81XWH-10-1-0679 TITLE: DOES LACTATION MITIGATE TRIPLE NEGATIVE/BASAL BREAST CANCER...2013 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER DOES LACTATION MITIGATE TRIPLE NEGATIVE/BASAL BREAST CANCER PROGRESSION? 5b. GRANT NUMBER...that this protective layer may be maintained by tumors formed during pregnancy lactation cycle, but may be preferentially compromised by tumors

  17. Can synergy in Triple Helix relations be quantified? A review of the development of the Triple Helix indicator

    NARCIS (Netherlands)

    Leydesdorff, L.; Park, H.W.

    2014-01-01

    Triple Helix arrangements of bi- and trilateral relations can be considered as adaptive ecosystems. During the last decade, we have further developed a Triple Helix indicator of synergy as reduction of uncertainty in niches that can be shaped among three or more sets of relations. Reduction of

  18. [Triple fracture of the shoulder suspensory complex].

    Science.gov (United States)

    Tamimi Mariño, I; Martin Rodríguez, I; Mora Villadeamigo, J

    2013-01-01

    The superior suspensory complex of the shoulder (SSCS) is a ring shaped structure composed of bones and soft tissues that play a fundamental role in the stability of the shoulder joint. Isolated injuries of the SSCS are relatively common, but injuries that affect 3 components are extremely unusual. We present a triple injury of the SSCS in a 26 year old patient with a Neer type ii clavicular fracture, a Kuhn type iii acromion fracture and an Ogawa type i coracoid fracture. An open reduction and stabilization of the clavicle was performed with 2 Kirschner nails. The acromial fracture was synthesized with 2 cannulated screws, and the coracoid fracture was treated conservatively. After 24 months of follow up the patient had an excellent functional outcome according to the Constat-Murley shoulder score and QuickDASH scoring system, and all the fractures healed correctly. Copyright © 2013 SECOT. Published by Elsevier Espana. All rights reserved.

  19. First Report of Tripled Retromolar Foramina.

    Science.gov (United States)

    He, Puhan; Iwanaga, Joe; Truong, Mindy K; Adeeb, Nimer; Tubbs, R Shane; Yamaki, Koh-Ichi

    2017-07-07

    The retromolar foramen (RMF) is the bony entrance of the retromolar canal, through which a neurovascular bundle runs. It is essential to locate such anatomic variants in a patient in order to avoid complications in surgery, implant placement, or anesthesia of the area. To our knowledge, there has only been one case report of supernumerary RMF, which reported one bilateral doubled retromolar foramina and one doubled left RMF. We present an extremely rare case in which a right triple RMF was observed on cone beam computed tomography in a cadaver. Diameters of the RMF were 0.8 mm, 1.0 mm and 1.1 mm, respectively. Distances from the distal edge of the third molar were measured as 4.0 mm, 3.6 mm, and 0.5 mm, respectively. RMF was not found on the left side of the mandible.

  20. Polarized triple-axis spectrometer TASP

    Energy Technology Data Exchange (ETDEWEB)

    Boeni, P.; Keller, P. [Lab. for Neutron Scattering ETH Zurich, Zurich (Switzerland) and Paul Scherrer Institute, Villigen (Switzerland)

    1996-11-01

    The polarized triple-axis spectrometer TASP at SINQ has been optimized for measuring magnetic cross sections in condensed matter. The neutrons are polarized or analyzed either by means of benders or Heusler monochromators. The beam divergence, i.e. the intensity, and the spectral range of the neutrons is rather large because of the supermirror coatings of the feeding neutron guide. The intensity can be further increased at the sample position by means of a focussing monochromator and a focussing anti-trumpet. The end position of TASP allows the tailoring of the neutron beam already before the monochromator and to scatter neutrons over very wide ranges of angles. (author) 6 figs., 1 tab., 8 refs.

  1. Triple-layer smart grid business model

    DEFF Research Database (Denmark)

    Ma, Zheng; Lundgaard, Morten; Jørgensen, Bo Nørregaard

    2016-01-01

    ), and identifies the parameters for the smart grid solutions to the emerging markets. This study develops a triple-layer business model including the organizational (Niche), environmental (Intermediate), and global (Dominators) factors. The result uncovers an interface of market factors and stakeholders......Viewing the smart grid with the theory of business models may open opportunities in understanding and capturing values in new markets. This study tries to discover and map the smart grid ecosystem-based business model framework with two different environments (sub-Saharan Africa and Denmark...... in a generic smart grid constellation. The findings contribute the transferability potential of the smart grid solutions between countries, and indicate the potential to export and import smart grid solutions based on the business modeling....

  2. Neutron triples counting data for uranium

    Science.gov (United States)

    Croft, Stephen; LaFleur, Adrienne M.; McElroy, Robert D.; Swinhoe, Martyn T.

    2015-06-01

    Correlated neutron counting using multiplicity shift register logic extracts the first three factorial moments from the detected neutron pulse train. The descriptive properties of the measurement item (mass, the ratio of (α,n) to spontaneous fission neutron production, and leakage self-multiplication) are related to the observed singles (S), doubles (D) and triples (T) rates, and this is the basis of the widely used multiplicity counting assay method. The factorial moments required to interpret and invert the measurement data in the framework of the point kinetics model may be calculated from the spontaneous fission prompt neutron multiplicity distribution P(ν). In the case of 238U very few measurements of P(ν) are available and the derived values, especially for the higher factorial moments, are not known with high accuracy. In this work, we report the measurement of the triples rate per gram of 238U based on the analysis of a set of measurements in which a collection of 10 cylinders of UO2F2, each containing about 230 g of compound, were measured individually and in groups. Special care was taken to understand and compensate the recorded multiplicity histograms for the effect of random cosmic-ray induced background neutrons, which, because they also come in bursts and mimic fissions but with a different and harder multiplicity distribution. We compare our fully corrected (deadtime, background, efficiency, multiplication) experimental results with first principles expectations based on evaluated nuclear data. Based on our results we suspect that the current evaluated nuclear data is biased, which points to a need to undertake new basic measurements of the 238U prompt neutron multiplicity distribution.

  3. Triple negative breast cancer: an Indian perspective

    Directory of Open Access Journals (Sweden)

    Akhtar M

    2015-08-01

    Full Text Available Murtaza Akhtar, Subhrajit Dasgupta, Murtuza Rangwala Department of Surgery, NKP Salve Institute of Medical Sciences and Research Centre, Nagpur, Maharashtra, India Introduction: Breast cancer is the most common female cancer in the world. Triple negative breast cancer (TNBC is a recently identified biological variant with aggressive tumor behavior and poor prognosis. Data of hormonal status from the Indian population is scarce due to financial constraints in performing immunohistochemistry evaluation. The present study aims to prospectively analyze receptor status of all breast cancer patients and identify TNBC and compare their clinical profile and short term survival with other non-TNBC group. Materials and methods: All cytologically and histopathologically confirmed cases of carcinoma breast were prospectively enrolled. In a longitudinal study at tertiary care hospital in central India based on the hormonal status, they were further divided into TNBC and other groups. Comparison of risk factors, clinical profile and short-term survival was carried out. Results: A total 85 patients were enrolled and of them 37 (43.7% were TNBC. On comparing risk factors ie, age, age at menarche, total reproductive age, age at first child birth, and menopausal status – no statistical significance was observed between the TNBC and non-TNBC groups. But on comparison of clinical profile TNBC tumors were significantly large with majority of patients presenting as locally advanced breast cancer (83%. No statistical difference was observed in axillary lymph node status between two groups. TNBC tumors were histologically more aggressive (grade 3 compared to other groups. No statistically significant difference was observed in short term overall survival but all three deaths were observed in the TNBC group only and two local recurrences after surgery were observed in the TNBC group. Conclusion: TNBC forms a large proportion of carcinoma breast patients in a central

  4. Fractura triple del complejo suspensorio del hombro

    Directory of Open Access Journals (Sweden)

    Eraclio Delgado Rifá

    2015-06-01

    Full Text Available El complejo suspensorio del hombro es una estructura sumamente importante, compuesta por un anillo de huesos y tejidos blandos. Las lesiones aisladas de este complejo anatómico son frecuentes y no afectan su estabilidad. La interrupción doble conduce a la inestabilidad de esta estructura y usualmente requiere tratamiento quirúrgico. La triple interrupción, por su parte, es sumamente rara y es encontrada en casos de trauma de alta energía a menudo en asociación con otras lesiones. Se presenta una triple lesión del complejo suspensorio del hombro en un paciente de 46 años de edad, con una fractura de la glenoides, del acromion tipo III de Kuhn y de la coracoides tipo II de Ogawa. En este caso, la fractura del acromion fue tratada con fijación percutánea con alambres de Kirschner, por tener asociado lesiones de partes blandas que contraindicaron la reducción abierta. La fractura de la glenoides y de la apófisis coracoides fueron tratadas conservadoramente. Después de 6 meses de evolución, el paciente tuvo un resultado funcional aceptable, con una abducción de 90 grados, los 30 grados de rotación externa y 70 de rotación interna, además asintomático y consolidación de todas las fracturas. A pesar de ser catalogada de una lesión grave del cinturón escapular y estar asociada a otras lesiones se obtuvo un resultado satisfactorio al final del tratamiento.

  5. The coupled cluster singles, doubles, and a hybrid treatment of connected triples based on the split virtual orbitals

    Science.gov (United States)

    Shen, Jun; Kou, Zhuangfei; Xu, Enhua; Li, Shuhua

    2012-01-01

    We have proposed a simple strategy for splitting the virtual orbitals with a large basis set into two subgroups (active and inactive) by taking a smaller basis set as an auxiliary basis set. With the split virtual orbitals (SVOs), triple or higher excitations can be partitioned into active and inactive subgroups (according to the number of active virtual orbitals involved), which can be treated with different electron correlation methods. In this work, the coupled cluster (CC) singles, doubles, and a hybrid treatment of connected triples based on the SVO [denoted as SVO-CCSD(T)-h], has been implemented. The present approach has been applied to study the bond breaking potential energy surfaces in three molecules (HF, F2, and N2), and the equilibrium properties in a number of open-shell diatomic molecules. For all systems under study, the SVO-CCSD(T)-h method based on the unrestricted Hartree-Fock (UHF) reference is an excellent approximation to the corresponding CCSDT (CC singles, doubles, and triples), and much better than the UHF-based CCSD(T) (CC singles, doubles, and perturbative triples). On the other hand, the SVO-CCSD(T)-h method based on the restricted HF (RHF) reference can also provide considerable improvement over the RHF-based CCSD(T).

  6. Simple guide to Skype

    CERN Document Server

    Winter, Rick

    2013-01-01

    Simple Guides give you Just the Facts Get up to speed with Skypefast! Simple Guides: get you started quickly. No extra clutter, no extra reading. Learn how to set up Skype, as well as how to add and set up all your friends, family, and other contacts. Find out about all the features of Skype, how to change views, set your status and conduct video and audio only calls. Learn about all the different things you can do to contact your friends and family on Skype for free, and start having fun!

  7. Droids Made Simple

    CERN Document Server

    Mazo, Gary

    2011-01-01

    If you have a Droid series smartphone - Droid, Droid X, Droid 2, or Droid 2 Global - and are eager to get the most out of your device, Droids Made Simple is perfect for you. Authors Martin Trautschold, Gary Mazo and Marziah Karch guide you through all of the features, tips, and tricks using their proven combination of clear instructions and detailed visuals. With hundreds of annotated screenshots and step-by-step directions, Droids Made Simple will transform you into a Droid expert, improving your productivity, and most importantly, helping you take advantage of all of the cool features that c

  8. Excel 2010 Made Simple

    CERN Document Server

    Katz, Abbott

    2011-01-01

    Get the most out of Excel 2010 with Excel 2010 Made Simple - learn the key features, understand what's new, and utilize dozens of time-saving tips and tricks to get your job done. Over 500 screen visuals and clear-cut instructions guide you through the features of Excel 2010, from formulas and charts to navigating around a worksheet and understanding Visual Basic for Applications (VBA) and macros. Excel 2010 Made Simple takes a practical and highly effective approach to using Excel 2010, showing you the best way to complete your most common spreadsheet tasks. You'll learn how to input, format,

  9. FUZZY SIMPLE ADDITIVE WEIGHTED (F-SAW SEBAGAI PENUNJANG KEPUTUSAN REKOMENDASI CALON PEMEGANG POLIS ASURANSI JIWA BERDASARKAN UNDERWRITING (SELEKSI RESIKO (STUDI KASUS : ASURANSI JIWA BERSAMA (AJB BUMIPUTERA 1912 CABANG BANJARBARU

    Directory of Open Access Journals (Sweden)

    Hendy Setyoputro

    2016-04-01

    Full Text Available The office of Asuransi Jiwa Bersama (AJB Bumiputera 1912 Banjarbaru branch has a system that regulates the recruitment of new policyholders in order to fulfill the achievement of success and protect the company from risk of loss, this system is referred to as underwriting. At each period per month from this process will leave approximately 50-100 prospective policyholder files that could not be checked again and finally considered prospective policyholders suspended (pending to apply insurance. This is certainly going to hurt the company and the prospective policyholders individual life insurance because the insurance risk is not guaranteed due to the manual process that takes a long time. In connection with the above, then made a decision support system that can help the office AJB Bumiputera 1912 Banjarbaru branch. In the calculation of recommendation prospective policyholders in this decision support system using the Simple Additive Weighted Fuzzy method (F-SAW. Waterfall is a system development method used in this research. The results of this decision support system in the form of data ranking prospective policyholders recommendations that are prioritized to take decisions based insurance accepted, considered, and rejected. Based on the research results and observations from decision support systems prospective policyholders recommendations based underwriting of life insurance (risk selection The suitability score is 90% and the remaining 10% are not in accordance with the decision of the office of AJB Bumiputera 1912 Banjarbaru branch. Keywords: F-SAW, Underwriting, Insurance. Kantor Asuransi Jiwa Bersama (AJB Bumiputera 1912 Cabang Banjarbaru memiliki sebuah sistem yang mengatur dalam penerimaan calon pemegang polis baru agar dapat memenuhi pencapaian kesuksesan dan melindungi perusahaan dari resiko kerugian, sistem ini disebut dengan istilah Underwriting. Pada setiap periode per bulannya dari proses ini akan menyisakan kurang lebih 50

  10. [Period-tripling in Multiscale Physical and Biological Events].

    Science.gov (United States)

    Bondar, A T; Fedorov, M V; Kolombet, V A

    2015-01-01

    A recent paper by S.J. Puetz et al. (Chaos, Solitons -& Fractals, v. 62-63, p. 55, 2014) described a fundamental period-tripled model. It involves periods of different astronomical (quasars, Sun), geophysical (geomagnetic, climatic, volcanic) and some biological processes. This work contains statistics for sixteen pairs of a period-tripled sequence. These periods range from -50 years to 1.5 billion years and no signs of the timescale limitations are found. We believe that the universal scope of the fundamental period-tripled model can be used for the development of new methodology of research data analysis: the main idea is that the spectrum of the periods of the studied event should be tested for the similarity with the spectrum of fundamental period-tripling pattern (because of the fundamental nature of the period-tripled model). Using this method, in this study we complement an already described period-tripled model with periods of human memory performance ranging from one minute to one month also adding seven relevant periods/frequencies of the period-tripled model in the range of human hearing. We make a conclusion that these characteristic frequencies may form the basis for music and singing phenomena. The new methodology is particularly appropriate for being applied in medicine and engineering.

  11. A Simple Hydrogen Electrode

    Science.gov (United States)

    Eggen, Per-Odd

    2009-01-01

    This article describes the construction of an inexpensive, robust, and simple hydrogen electrode, as well as the use of this electrode to measure "standard" potentials. In the experiment described here the students can measure the reduction potentials of metal-metal ion pairs directly, without using a secondary reference electrode. Measurements…

  12. (3) Simple processing method

    African Journals Online (AJOL)

    Adeyinka Odunsi

    Simple Processing Method for Recycling Poultry Waste into. Animal Feed Ingredient. *Komolafe, A. A. and Sonaiya, E. B. ... recycled and become consumables to livestock, thus entering the human food chain. Poultry waste is not ... on the concrete roof (20.5 m high) of the Faculty of Agriculture, Obafemi. Awolowo University ...

  13. On Pythagoras Theorem for Products of Spectral Triples

    Science.gov (United States)

    D'Andrea, Francesco; Martinetti, Pierre

    2013-05-01

    We discuss a version of Pythagoras theorem in noncommutative geometry. Usual Pythagoras theorem can be formulated in terms of Connes' distance, between pure states, in the product of commutative spectral triples. We investigate the generalization to both non-pure states and arbitrary spectral triples. We show that Pythagoras theorem is replaced by some Pythagoras inequalities, that we prove for the product of arbitrary (i.e. non-necessarily commutative) spectral triples, assuming only some unitality condition. We show that these inequalities are optimal, and we provide non-unital counter-examples inspired by K-homology.

  14. A Study of Neoadjuvant Paclitaxel in Combination With Bavituximab in Early- Stage Triple- Negative Breast Cancer

    Science.gov (United States)

    2017-03-08

    Breast Cancer; Triple Negative Breast Neoplasms; Triple-Negative Breast Neoplasm; Triple-Negative Breast Cancer; Triple Negative Breast Cancer; ER-Negative PR-Negative HER2-Negative Breast Neoplasms; ER-Negative PR-Negative HER2-Negative Breast Cancer

  15. Tripled Fixed Point in Ordered Multiplicative Metric Spaces

    Directory of Open Access Journals (Sweden)

    Laishram Shanjit

    2017-06-01

    Full Text Available In this paper, we present some triple fixed point theorems in partially ordered multiplicative metric spaces depended on another function. Our results generalise the results of [6] and [5].

  16. Triple Isotope Water Analyzer for Extraplanetary Studies Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Los Gatos Research (LGR) proposes to employ Off-Axis ICOS to develop triple-isotope water analyzers for lunar and other extraplanetary exploration. This instrument...

  17. Triple Isotope Water Analyzer for Extraplanetary Studies Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In this Small Business Innovative Research (SBIR) effort, Los Gatos Research (LGR) proposes to develop a miniature, high-resolution, low power, triple-isotope water...

  18. Modern mathematics made simple

    CERN Document Server

    Murphy, Patrick

    1982-01-01

    Modern Mathematics: Made Simple presents topics in modern mathematics, from elementary mathematical logic and switching circuits to multibase arithmetic and finite systems. Sets and relations, vectors and matrices, tesselations, and linear programming are also discussed.Comprised of 12 chapters, this book begins with an introduction to sets and basic operations on sets, as well as solving problems with Venn diagrams. The discussion then turns to elementary mathematical logic, with emphasis on inductive and deductive reasoning; conjunctions and disjunctions; compound statements and conditional

  19. The simple complex numbers

    OpenAIRE

    Zalesny, Jaroslaw

    2008-01-01

    A new simple geometrical interpretation of complex numbers is presented. It differs from their usual interpretation as points in the complex plane. From the new point of view the complex numbers are rather operations on vectors than points. Moreover, in this approach the real, imaginary and complex numbers have similar interpretation. They are simply some operations on vectors. The presented interpretation is simpler, more natural, and better adjusted to possible applications in geometry and ...

  20. Information technology made simple

    CERN Document Server

    Carter, Roger

    1991-01-01

    Information Technology: Made Simple covers the full range of information technology topics, including more traditional subjects such as programming languages, data processing, and systems analysis. The book discusses information revolution, including topics about microchips, information processing operations, analog and digital systems, information processing system, and systems analysis. The text also describes computers, computer hardware, microprocessors, and microcomputers. The peripheral devices connected to the central processing unit; the main types of system software; application soft

  1. Statistical mechanics of the triple contact line.

    Science.gov (United States)

    Louge, Michel Y

    2017-03-01

    We outline a statistical mechanics of the triple gas-solid-liquid contact line on a rough plane. The analysis regards the neighborhood of the line as a solid dotted with cavities. It adopts the simplest mean-field statistical mechanics, in which each cavity is either full or empty, while being connected to near neighbors by thin necks. The theory predicts equilibrium angles for advance and recession in terms of the Young contact angle and the joint statistical distribution of two quantifiable geometrical parameters representing specific neck cross-section and specific cavity opening. It attributes contact angle hysteresis to first-order phase transitions among adjacent cavities, as they collectively imbibe or reject liquid. It also calculates the potential energy barriers that hysteresis erects against overcoming contact line pinning. By determining whether the phase transitions can release latent energy, this ab initio analysis distinguishes six regimes, including two metastable recession states. We compare predictions with data for superhydrophobia on microscopic rods; for hysteresis in the "Wenzel state"; and for variations of the advancing contact angle with surface energies of the liquid.

  2. Tripled coincidence and fixed point results in partial metric spaces

    Directory of Open Access Journals (Sweden)

    Hassen Aydi

    2012-10-01

    Full Text Available In this paper, we introduce the concept of W-compatiblity of mappings F : X × X × X ! X and g : X ! X and based on this notion, we obtain tripled coincidence and common tripled fixed point results in the setting of partial metric spaces. The presented results generalize and extend several well known comparable results in the existing literature. We also provide an example to support our results.

  3. Continuous variables triple-photon states quantum entanglement

    OpenAIRE

    Gonzalez, E. A. Rojas; Borne, A.; Boulanger, B.; Levenson, J.A.; Bencheikh, K

    2017-01-01

    We investigate the quantum entanglement of the three modes associated with the three-photon states obtained by triple-photon generation in a phase-matched third-order nonlinear optical interaction. Although the second order processes have been extensively dealt with, there is no direct analogy between the second and third-order mechanisms. We show for example the absence of quantum entanglement between the quadratures of the three modes in the case of spontaneous parametric triple-photon gene...

  4. Epigenetic Subtypes of Triple-Negative Breast Cancer

    Science.gov (United States)

    2015-10-01

    CRISPR screen to investigate mechanisms of resistance to epigenetic therapies. POC: Program Administrator Sylvia C. Lin Email: Sylvia_Lin...1 AD______________ AWARD NUMBER: W81XWH-14-1-0213 TITLE: Epigenetic Subtypes of Triple-Negative Breast Cancer PRINCIPAL INVESTIGATOR...SUBTITLE Epigenetic Subtypes of Triple-Negative Breast Cancer 5a. CONTRACT NUMBER W81XWH-14-1-0213 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6

  5. A Stakeholder Approach to Triple Bottom Line Accounting: Nigerian Experience

    OpenAIRE

    Okenwa Cy Ogbodo

    2015-01-01

    The broad objective of this study is to determine whether triple bottom line reports has been able to deliver stakeholders with the needed satisfaction when compared to conventional financial reports. To achieve the above objective three research questions were raised, to address the issue of triple bottom line report and stakeholder satisfaction. From these hypotheses were formulated. The descriptive method of research design was employed to generate the required data. The population of were...

  6. External Validation and Evaluation of Reliability and Validity of the Triple D Score to Predict Stone-Free Status After Extracorporeal Shockwave Lithotripsy.

    Science.gov (United States)

    Ozgor, Faruk; Tosun, Muhammed; Kayali, Yunus; Savun, Metin; Binbay, Murat; Tepeler, Abdulkadir

    2017-02-01

    The Triple D scoring system is defined as novel and simple nomogram using the main parameters (skin-to-stone distance, stone density, and volume) to indicate most appropriate patients for extracorporeal shockwave lithotripsy (SWL). We aimed to evaluate the accuracy of the Triple D scoring system in predicting SWL success rates. In two tertiary academic centers, charts were retrospectively analyzed of patients who had, between January 2014 and May 2016, been treated by SWL for radiopaque kidney stones. A total of 200 patients were enrolled into the study. Parameters were calculated for each of the three specified variables. Since one point was assigned for any parameter that was less than the cutoff value, Triple D scores ranged from 0 (worst) to 3 (best). Stone-free status was achieved in 115 patients (57.5%), and 85 patients had one or more residual fragments (42.5%). Differences in stone characteristics, including stone location, density, and volume, were statistically significant in patients whether SWL achieved stone-free status or not (p p p Triple D scores were significantly higher in patients treated with SWL compared with patients in whom SWL failed (p Triple D scores of 0, 1, 2, and 3 correlated with stone-free rates of 41.7%, 33.7%, 69.4%, and 97%, respectively. The multivariate analyses revealed that Triple D score and stone location were identified as independent factors affecting SWL success (p p = 0.008, respectively). The mean number of SWL sessions was significantly higher in patients with SWL failure (p = 0.003). Our study externally validates that the Triple D scoring system is associated with SWL success in the treatment of renal and ureteral stones. Further studies are warranted to assess clinical usefulness and the accuracy of this nomogram in different patient groups.

  7. Broad-search algorithms for finding triple-and quadruple-satellite-aided captures at Jupiter from 2020 to 2080

    Science.gov (United States)

    Lynam, Alfred E.

    2015-04-01

    Multiple-satellite-aided capture is a -efficient technique for capturing a spacecraft into orbit at Jupiter. However, finding the times when the Galilean moons of Jupiter align such that three or four of them can be encountered in a single pass is difficult using standard astrodynamics algorithms such as Lambert's problem. In this paper, we present simple but powerful techniques that simplify the dynamics and geometry of the Galilean satellites so that many of these triple- and quadruple-satellite-aided capture sequences can be found quickly over an extended 60-year time period from 2020 to 2080. The techniques find many low-fidelity trajectories that could be used as initial guesses for future high-fidelity optimization. Results indicate the existence of approximately 3,100 unique triple-satellite-aided capture trajectories and 6 unique quadruple-satellite-aided capture trajectories during the 60-year time period. The entire search takes less than one minute of computational time.

  8. PENGARUH PERSEPSI TENTANG SANKSI PERPAJAKAN DAN KESADARAN WAJIB PAJAK PADA KEPATUHAN PELAPORAN WAJIB PAJAK ORANG PRIBADI DI KANTOR PELAYANAN PAJAK PRATAMA DENPASAR TIMUR

    Directory of Open Access Journals (Sweden)

    Ni Ketut Muliari

    2011-01-01

    Full Text Available Tax revenue has been the most substantial source of government incomerecently. In 2009, about 73 percent of government revenue came from taxes. Thisforces taxation office to perform some efforts to maximize tax revenue. One of them isto employ self assessment system. In this system, taxpayer’s awareness andcompliance is important. Factors influencing taxpayer’s compliance includetaxpayer’s perception of tax penalty and taxpayer’s awareness.This research aims to examine the effect of perception of tax penalty and taxawareness on taxpayer’s compliance in taxation office Pratama Denpasar Timur.Sample is drawn using simple random sampling method, and consists of 100effective taxpayers as respondents. Data then are analyzed using multiple linearregression technique. The result shows that perception of tax penalty and taxpayer’sawareness simultaneously affects taxpayer’s compliance with adjusted R-square of0.498. Partially, the two variables provide significant positive effect on taxpayer’scompliance.

  9. Transformation rules for decomposing heterogeneous data into triples

    Directory of Open Access Journals (Sweden)

    Mrityunjay Singh

    2015-04-01

    Full Text Available In order to fulfill the vision of a dataspace system, it requires a flexible, powerful and versatile data model that is able to represent a highly heterogeneous mix of data such as databases, web pages, XML, deep web, and files. In literature, the triple model was found a suitable candidate for a dataspace system, and able to represent structured, semi-structured and unstructured data into a single model. A triple model is based on the decomposition theory, and represents variety of data into a collection of triples. In this paper, we have proposed a decomposition algorithm for expressing various heterogeneous data models into the triple model. This algorithm is based on the decomposition theory of the triple model. By applying the decomposition algorithm, we have proposed a set of transformation rules for the existing data models. The transformation rules have been categorized for structured, semi-structured, and unstructured data models. These rules are able to decompose most of the existing data models into the triple model. We have empirically verified the algorithm as well as the transformation rules on different data sets having different data models.

  10. Strain mapping of a triple junction in nanocrystalline Pd

    Energy Technology Data Exchange (ETDEWEB)

    Roesner, Harald, E-mail: rosner@uni-muenster.de [Institut fuer Materialphysik, Westfaelische Wilhelms-Universitaet Muenster, Wilhelm-Klemm-Strasse 10, D-48149 Muenster (Germany); Kuebel, Christian [Karlsruhe Institute of Technology, Institute of Nanotechnology, Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany); Karlsruhe Nano Micro Facility, Karlsruhe Institute of Technology, D-76344 Eggenstein-Leopoldshafen (Germany); Ivanisenko, Yulia; Kurmanaeva, Lilia [Karlsruhe Institute of Technology, Institute of Nanotechnology, Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany); Divinski, Sergiy V.; Peterlechner, Martin; Wilde, Gerhard [Institut fuer Materialphysik, Westfaelische Wilhelms-Universitaet Muenster, Wilhelm-Klemm-Strasse 10, D-48149 Muenster (Germany)

    2011-11-15

    Aberration-corrected transmission electron microscopy was used to provide structural information on a triple junction in nanocrystalline Pd. This triple junction consists of two intersecting {Sigma}3 twin boundaries with a {Sigma}9 grain boundary and is connected to a quadruple point via the {Sigma}9 grain boundary. A comprehensive strain analysis of this triple junction using geometric phase analysis is presented and compared with a molecular dynamics simulation. The main results are: (i) the strain field of the core of the triple junction shows dislocation character and extends over a distance of about 0.5 nm; (ii) the intersecting boundaries result in a net translation of (a{sub 0})/({radical}(2)) , which corresponds to a Burgers vector of an (a{sub 0})/2 <110> dislocation in the fcc lattice; (iii) a disclination emerging from the triple junction along the {Sigma}9 grain boundary is balanced by a disclination of opposite sign emerging from the quadruple point. Based on the observation that the core of the triple junction can be described by the strain field of a dislocation, its energy was estimated using 1/2 Gb{sup 2} to be about 1.7 x 10{sup -9} J m{sup -1}. The presence of a disclination dipole is thought to be essential for stabilization of the structure observed.

  11. Improving species-specific IDMS: the advantages of triple IDMS.

    Science.gov (United States)

    Frank, Claudia; Rienitz, Olaf; Swart, Claudia; Schiel, Detlef

    2013-02-01

    Triple isotope dilution mass spectrometry (triple IDMS) has been applied for the first time on protein quantification, especially on transferrin. Transferrin as an acute phase protein is a marker for several inflammation processes in the human body. Therefore, in Germany, the accurate and precise measurement of this important analyte is required. In this work, a new approach to triple IDMS is described and compared to double IDMS. Also, complete uncertainty budgets for both methods were set up to demonstrate the ability of this method to be used as a reference procedure. The relative expanded uncertainty (k=2) for triple IDMS (3.6 %) is smaller than the one for double IDMS (4.0 %). The content of transferrin found in the human serum reference material ERM-DA470k/IFCC ((2.41±0.08) g/kg) with both methods was in good agreement with each other and with the certificate. For triple IDMS ((2.426±0.086) g/kg) and for double IDMS ((2.317±0.092) g/kg), transferrin was determined. Although triple IDMS is a little more time consuming compared to double IDMS, there is the advantage that the isotopic composition of the spike material does not have to be determined. This is very useful especially in case of a marginal isotopic enrichment in the spike or problems with the accurate measurement of the spike isotope ratio.

  12. Oral Tranexamic Acid with Fluocinolone-Based Triple Combination Cream Versus Fluocinolone-Based Triple Combination Cream Alone in Melasma: An Open Labeled Randomized Comparative Trial

    National Research Council Canada - National Science Library

    Padhi, Tanmay; Pradhan, Swetalina

    2015-01-01

    .... To compare the efficacy of a combination of oral tranexamic acid and fluocinolone-based triple combination cream with that of fluocinolone-based triple combination cream alone in melasma among Indian patients...

  13. Simple chain grammars and languages

    NARCIS (Netherlands)

    Nijholt, Antinus

    1979-01-01

    A subclass of the LR(0)-grammars, the class of simple chain grammars is introduced. Although there exist simple chain grammars which are not LL(k) for any k>0, this new class of grammars is very closely related to the LL(1) and simple LL(1) grammars. In fact it can be shown that every simple chain

  14. Data processing made simple

    CERN Document Server

    Wooldridge, Susan

    2013-01-01

    Data Processing: Made Simple, Second Edition presents discussions of a number of trends and developments in the world of commercial data processing. The book covers the rapid growth of micro- and mini-computers for both home and office use; word processing and the 'automated office'; the advent of distributed data processing; and the continued growth of database-oriented systems. The text also discusses modern digital computers; fundamental computer concepts; information and data processing requirements of commercial organizations; and the historical perspective of the computer industry. The

  15. Applied mathematics made simple

    CERN Document Server

    Murphy, Patrick

    1982-01-01

    Applied Mathematics: Made Simple provides an elementary study of the three main branches of classical applied mathematics: statics, hydrostatics, and dynamics. The book begins with discussion of the concepts of mechanics, parallel forces and rigid bodies, kinematics, motion with uniform acceleration in a straight line, and Newton's law of motion. Separate chapters cover vector algebra and coplanar motion, relative motion, projectiles, friction, and rigid bodies in equilibrium under the action of coplanar forces. The final chapters deal with machines and hydrostatics. The standard and conte

  16. Theory of simple liquids

    CERN Document Server

    Hansen, Jean-Pierre

    1986-01-01

    This book gives a comprehensive and up-to-date treatment of the theory of ""simple"" liquids. The new second edition has been rearranged and considerably expanded to give a balanced account both of basic theory and of the advances of the past decade. It presents the main ideas of modern liquid state theory in a way that is both pedagogical and self-contained. The book should be accessible to graduate students and research workers, both experimentalists and theorists, who have a good background in elementary mechanics.Key Features* Compares theoretical deductions with experimental r

  17. Beyond Simple Headquarters Configurations

    DEFF Research Database (Denmark)

    Dellestrand, Henrik; Kappen, Philip; Nell, Phillip Christopher

    .e., an innovation that is important for the firm beyond the divisional boundaries, drives dual headquarters involvement in innovation development. Contrary to expectations, on average, a non-significant effect of cross-divisional embeddedness on dual headquarters involvement is found. Yet, both cross......-divisional importance and embeddedness effects are contingent on the overall complexity of the innovation project as signified by the size of the development network. The results lend support for the notion that parenting in complex structures entails complex headquarters structures and that we need to go beyond simple...

  18. Simple Driving Techniques

    DEFF Research Database (Denmark)

    Rosendahl, Mads

    2002-01-01

    Driving was introduced as a program transformation technique by Valentin Turchin in some papers around 1980. It was intended for the programming language REFAL and used in metasystem transitions based on super compilation. In this paper we present one version of driving for a more conventional lisp......-like language. Our aim is to extract a simple notion of driving and show that even in this tamed form it has much of the power of more general notions of driving. Our driving technique may be used to simplify functional programs which use function composition and will often be able to remove intermediate data...

  19. ASP made simple

    CERN Document Server

    Deane, Sharon

    2003-01-01

    ASP Made Simple provides a brief introduction to ASP for the person who favours self teaching and/or does not have expensive computing facilities to learn on. The book will demonstrate how the principles of ASP can be learned with an ordinary PC running Personal Web Server, MS Access and a general text editor like Notepad.After working through the material readers should be able to:* Write ASP scripts that can display changing information on a web browser* Request records from a remote database or add records to it* Check user names & passwords and take this knowledge forward, either for their

  20. Predicted thermal performance of triple vacuum glazing

    Energy Technology Data Exchange (ETDEWEB)

    Fang, Yueping; Hyde, Trevor J.; Hewitt, Neil [School of the Built Environment, University of Ulster, N. Ireland (United Kingdom)

    2010-12-15

    The simulated triple vacuum glazing (TVG) consists of three 4 mm thick glass panes with two vacuum gaps, with each internal glass surface coated with a low-emittance coating with an emittance of 0.03. The two vacuum gaps are sealed by an indium based sealant and separated by a stainless steel pillar array with a height of 0.12 mm and a pillar diameter of 0.3 mm spaced at 25 mm. The thermal transmission at the centre-of-glazing area of the TVG was predicted to be 0.26 W m{sup -2} K{sup -1}. The simulation results show that although the thermal conductivity of solder glass (1 W m{sup -1} K{sup -1}) and indium (83.7 W m{sup -1} K{sup -1}) are very different, the difference in thermal transmission of TVGs resulting from the use of an indium and a solder glass edge seal was 0.01 W m{sup -2} K{sup -1}. This is because the edge seal is so thin (0.12 mm), consequently there is a negligible temperature drop across it irrespective of the material that the seal is made from relative to the total temperature difference across the glazing. The results also show that there is a relatively large increase in the overall thermal conductance of glazings without a frame when the width of the indium edge seal is increased. Increasing the rebate depth in a solid wood frame decreased the heat transmission of the TVG. The overall heat transmission of the simulated 0.5 m by 0.5 m TVG was 32.6% greater than that of the 1 m by 1 m TVG, since heat conduction through the edge seal of the small glazing has a larger contribution to the total glazing heat transfer than that of the larger glazing system. (author)

  1. The triple-A supply chain.

    Science.gov (United States)

    Lee, Hau L

    2004-10-01

    Building a strong supply chain is essential for business success. But when it comes to improving their supply chains, few companies take the right approach. Many businesses work to make their chains faster or more cost-effective, assuming that those steps are the keys to competitive advantage. To the contrary: Supply chains that focus on speed and costs tend to deteriorate over time. The author has spent 15 years studying more than 60 companies to gain insight into this and other supply chain dilemmas. His conclusion: Only companies that build supply chains that are agile, adaptable, and aligned get ahead of their rivals. All three components are essential; without any one of them, supply chains break down. Great companies create supply chains that respond to abrupt changes in markets. Agility is critical because in most industries, both demand and supply fluctuate rapidly and widely. Supply chains typically cope by playing speed against costs, but agile ones respond both quickly and cost-efficiently. Great companies also adapt their supply networks when markets or strategies change. The best supply chains allow managers to identify structural shifts early by recording the latest data, filtering out noise, and tracking key patterns. Finally, great companies align the interests of the partners in their supply chains with their own. That's important because every firm is concerned solely with its own interests. If its goals are out of alignment with those of other partners in the supply chain, performance will suffer. When companies hear about the triple-A supply chain, they assume that building one will require increased technology and investment. But most firms already have the infrastructure in place to create one. A fresh attitude alone can go a long way toward making it happen.

  2. Elastographic features of triple negative breast cancers.

    Science.gov (United States)

    Džoić Dominković, Martina; Ivanac, Gordana; Kelava, Tomislav; Brkljačić, Boris

    2016-04-01

    To evaluate shear-wave elastographic (SWE) features of triple negative breast cancers (TNBC) and determine useful discriminators from other types of invasive breast cancers. SWE features of 26 TNBC were reviewed and compared to 32 non-TNBC. Qualitative SWE features of lesion colour appearance, shape and homogeneity were analysed. Quantitative features were measured: mean (El mean), maximum (El max) and minimum (El min) elasticity value of the stiffest portion of the mass, mean elasticity of the surrounding tissue (El mean surr) and lesion to fat elasticity ratio (E ratio). TNBC are more often regularly shaped (57.7 % vs. 6.2 %), while non-TNBC are more commonly red (93.7 % vs 42.3 %) and heterogeneous (68.7 % vs 42.3 %). The stiffness of TNBC is significantly lower compared to non-TNBC. The two groups could be distinguished on the basis of El max (p = 0.001), El mean (p = 0.001), El min (p = 0.001) and E ratio (p = 0.0017). Lesion to fat elasticity ratio in TNBC group was statistically significantly lower than in the non-TNBC control group (p = 0.009). TNBC often demonstrate benign morphological features, are softer on SWE and have a lower lesion to fat stiffness ratio compared to the other, more common types of invasive breast cancers. • TNBC often demonstrate benign morphological features on SWE. • TNBC present on elastography mostly as red, regularly shaped, heterogeneous lesions. • TNBC are less stiff compared to other invasive breast cancers. • TNBC have lower lesion to fat stiffness ratio than other breast cancers.

  3. [Triple endobutton technique for repair of chronic complete acromioclavicular joint dislocations].

    Science.gov (United States)

    Zhu, Jianwei; Liu, Fan; Zhang, Jianhua; Dong, Qirong; Li, Shuai; De, Si

    2012-02-01

    To evaluate the early result of triple Endobutton technique for reconstructing coracoclavicular ligament of chronic complete acromioclavicular joint dislocations. Between January 2009 and June 2010, 14 patients with chronic complete acromioclavicular joint dislocations were treated with triple Endobutton technique for reconstructing coracoclavicular ligament. There were 10 males and 4 females with a mean age of 38.5 years (range, 26-52 years). Injury was caused by traffic accident in 7 cases, by falling in 5 cases, and by bruise in 2 cases. The average time was 47 days from injury to the operation (range, 29-75 days). All patients had pain and activity restriction. The X-ray films showed complete dislocation of acromioclavicular joint. According to Allman's type, all cases were classified as III degree complete dislocations. At postoperation, wound healed by first intention with no early complication of infection or neurovascular injury. All patients were followed up 18.3 months on average (range, 13-30 months). Acromioclavicular joint subluxation occurred in 1 patient at 1 week after operation, and no redislocation or other complication occurred in the other patients. American Shoulder and Elbow Surgeons (ASES) score was 90.8 +/- 4.1 at last follow-up, showing significant difference when compared with the preoperative score (65.3 +/- 4.4) (t = -17.57, P = 0.00); Constant-Murley score was 91.7 +/- 3.9, showing significant difference when compared with preoperative one (71.5 +/- 4.6) (t = -75.02, P = 0.00). The definite answer in Simple Shoulder Test (SST) averaged 9.7 (range, 7-12). The triple Endobutton technique for reconstructing coracoclavicular ligament is an effective method in treatment of chronic complete acromioclavicular joint dislocations. The short-term results are satisfactory.

  4. The cost of choice: a price too high in the triple screen for Down syndrome.

    Science.gov (United States)

    Elkins, T E; Brown, D

    1993-09-01

    At US national medical society meetings in 1992, researchers from a major university presented their data on a triple screen of maternal serum tests for the detection of trisomy 21 or fetal Down syndrome. Low maternal serum levels of estriol and alpha-fetoprotein, along with a high level of human chorionic gonadotropin can predict pregnancies at risk. The authors claimed that a person with Down syndrome costs approximately $196,000 including health, education, and residential costs. Simple economic costs about persons with Down syndrome in the cost analysis seem unbalanced. Some recent studies show no increase in divorce rates for families including persons with Down syndrome. In a 1971 review of 104 brothers and sisters of persons with Down syndrome, no specific behavioral disturbances were noted. Among complex costs triple screening threatens the integrity of the medical profession. Genetics counselors promoting nondirective informed consent, but the cost analysis description of Down syndrome are in the mild-to-moderate mental retardation range consistent with a 3rd-9th grade reading level. Less than 1% have leukemia, and less than 3% have in operable cardiac disease. Another cost that is difficult to measure includes the value placed on the maternal, paternal, and familial anxiety caused by genetic screening tests. Triple screening for Down syndrome is about societal concerns and social character. Many methods of health care rationing await the American medical system. A large number of factors must be considered before any system of limiting costs and choices is selected in a pluralistic society. Accepting the fact that limitations to choice must occur is the first step toward future rationality in genetic counseling.

  5. Triple-loaded single-anchor stitch configurations: an analysis of cyclically loaded suture-tendon interface security.

    Science.gov (United States)

    Coons, David A; Barber, F Alan; Herbert, Morley A

    2006-11-01

    This study evaluated the strength and suture-tendon interface security of different suture configurations from triple-suture-loaded anchors. A juvenile bovine infraspinatus tendon was detached and repaired by use of 4 different suture combinations from 2 suture anchors: 3 simple sutures in each anchor (ThreeVo anchor; Linvatec, Largo, FL); 2 peripheral simple stitches and 1 central horizontal mattress suture passed deeper into the tendon, creating a larger footprint (bigfoot-print anchor); 2 peripheral simple stitches with 1 central horizontal mattress stitch passed through the same holes as the simple sutures (stitch-of-Burns); and 2 simple stitches (TwoVo anchor; Linvatec). The constructs were cyclically loaded between 10 N and 180 N for 3,500 cycles and then destructively tested. The number of cycles required to create a 5-mm gap and a 10-mm gap and the ultimate load to failure and failure mode were recorded. The ThreeVo anchor was strongest and most resistant to cyclic loading (P anchor was least resistant to cyclic loading. The stitch-of-Burns anchor was more resistant to cyclic loading than both the bigfoot-print anchor and the TwoVo anchor (P anchors were stronger than the bigfoot-print anchor (P sutures in an anchor hold better than two simple sutures. Three simple sutures provide superior suture-tendon security than combinations of one mattress and two simple stitches subjected to cyclic loading. A central mattress stitch placed more medially than two peripheral simple stitches (bigfoot-print anchor) configured to enlarge the tendon-suture footprint was not as resistant to cyclic loading or destructive testing as three simple stitches (ThreeVo anchor). Placing a central mattress stitch more medially than 2 peripheral simple stitches to enlarge the tendon-suture footprint was not as resistant to cyclic loading or destructive testing as 3 simple stitches.

  6. THE SIMPLE SDD

    Energy Technology Data Exchange (ETDEWEB)

    Fernandes, A.; Morlat, T.; Felizardo, M.; Collar, J. I.; Puibasset, J.; Waysand, G.; Miley, Harry S.; Ramos, A. R.; Girard, T. A.; Giuliani, F.; Limagne, D.; Marques, J. G.; Martins, R. C.; Oliveira, C.

    2006-09-01

    SIMPLE (superheated instrument for massive particle search) is an experiment(1,2) to search for evidence of spin-dependent dark matter using fluorine-loaded superheated droplet detectors (SDDs). The application of the detector is based on the presence of fluorine, which possesses the highest figure-of-merit for spin-dependent interactions. Furthermore, these devices are virtually insensitive to the majority of backgrounds associated with such searches. For dark matter applications, less than 10 events kg-1 d-1 are expected. The sensitivity to backgrounds is therefore an important issue for detector use. Following the thermal spike model of Seitz(3), there are two thresholds for bubble nucleation: (1) the deposited energy must be larger than the work of formation of a critical nucleus (Ec) and (2) Ec must be deposited over a distance of the order of a critical radius (rc). Both thresholds can be tuned by modifying the operating conditions as to render the SDD insensitive to radiations depositing less than ~200 keV mm-1. Although the SDD can be made insensitive to energetic muons, gamma rays, X rays and electrons with linear energy transfer (LET) below this threshold, response to neutrons and alpha particles remains problematic. These originate from radioactivity in the rock, detector shielding and the detector itself. We describe the detector fabrication and response studies required by the large volume and concentration of the SIMPLE device.

  7. Probabilistic simple sticker systems

    Science.gov (United States)

    Selvarajoo, Mathuri; Heng, Fong Wan; Sarmin, Nor Haniza; Turaev, Sherzod

    2017-04-01

    A model for DNA computing using the recombination behavior of DNA molecules, known as a sticker system, was introduced by by L. Kari, G. Paun, G. Rozenberg, A. Salomaa, and S. Yu in the paper entitled DNA computing, sticker systems and universality from the journal of Acta Informatica vol. 35, pp. 401-420 in the year 1998. A sticker system uses the Watson-Crick complementary feature of DNA molecules: starting from the incomplete double stranded sequences, and iteratively using sticking operations until a complete double stranded sequence is obtained. It is known that sticker systems with finite sets of axioms and sticker rules generate only regular languages. Hence, different types of restrictions have been considered to increase the computational power of sticker systems. Recently, a variant of restricted sticker systems, called probabilistic sticker systems, has been introduced [4]. In this variant, the probabilities are initially associated with the axioms, and the probability of a generated string is computed by multiplying the probabilities of all occurrences of the initial strings in the computation of the string. Strings for the language are selected according to some probabilistic requirements. In this paper, we study fundamental properties of probabilistic simple sticker systems. We prove that the probabilistic enhancement increases the computational power of simple sticker systems.

  8. Pursuing the Triple Aim: The First 7 Years

    Science.gov (United States)

    Whittington, John W; Nolan, Kevin; Lewis, Ninon; Torres, Trissa

    2015-01-01

    Context In 2008, researchers at the Institute for Healthcare Improvement (IHI) described the Triple Aim as simultaneously “improving the individual experience of care; improving the health of populations; and reducing the per capita costs of care for populations.” IHI and its close colleagues had determined that both individual and societal changes were needed. Methods In 2007, IHI began recruiting organizations from around the world to participate in a collaborative to implement what became known as the Triple Aim. The 141 participating organizations included health care systems, hospitals, health care insurance companies, and others closely tied to health care. In addition, key groups outside the health care system were represented, such as public health agencies, social services groups, and community coalitions. This collaborative provided a structure for observational research. By noting the contrasts between the contexts and structures of those sites in the collaborative that progressed and those that did not, we were able to develop an ex post theory of what is needed for an organization or community to successfully pursue the Triple Aim. Findings Drawing on our 7 years of experience, we describe the 3 major principles that guided the organizations and communities working on the Triple Aim: creating the right foundation for population management, managing services at scale for the population, and establishing a learning system to drive and sustain the work over time. Conclusions The concept of the Triple Aim is now widely used, because of IHI's work with many organizations and also because of the adoption of the Triple Aim as part of the national strategy for US health care, developed during the implementation of the Patient Protection and Affordable Care Act of 2010. Even those organizations working on the Triple Aim before IHI coined the term found our concept to be useful because it helped them think about all 3 dimensions at once and organize their

  9. The interface of mental health and human rights in Indigenous peoples: triple jeopardy and triple opportunity.

    Science.gov (United States)

    Tarantola, Daniel

    2007-01-01

    Insufficient understanding of the reciprocal interactions between health and human rights, mental health and human rights and the realization of all human rights by Indigenous peoples constitute a triple jeopardy in how these topics are currently being addressed and/or openly antagonized. This paper will attempt to show how a combined health and human rights approach to mental health in Indigenous peoples can transform a triple jeopardy into a triple opportunity. The vast and growing body of literature on mental health, health as a whole, and human rights as these relate to health and to Indigenous peoples will be used to frame the discussion. Attention to the complex interactions of health and human rights can guide policy formulation and action by offering a method of analysis, a process of participatory decision and a framework for accountability. In addition, mental health can find its rightful place in the health and human rights discourse through efforts to help policymakers and practitioners broaden their vision of mental illness to holistically encompass aspects of physical, social, emotional and cultural wellbeing. Finally, connecting the role that rights realization plays in determining health and wellbeing will add power to the rightful claims by Indigenous peoples to the promotion and protection of all their human rights--civil, political, economic, social and cultural. Broadening the research agenda by applying systematically a health and human rights analytical framework to the understanding of social determinants of health would minimize the risk of assigning health outcome merely to behaviours, practices and lifestyles, uncovering structural determinants of holistic health entrenched in policies and governmental conduct. Building the evidence of the negative impact of human rights violation on health and the negative impact of ill-health on the fulfilment of other human rights can help in designing comprehensive interventions, building on the

  10. Design of triple-shape memory polyurethane with photo-cross-linking of cinnamon groups.

    Science.gov (United States)

    Wang, Lin; Yang, Xifeng; Chen, Hongmei; Gong, Tao; Li, Wenbing; Yang, Guang; Zhou, Shaobing

    2013-11-13

    A triple-shape memory polyurethane (TSMPU) with poly(ε-caprolactone) -diols (PCL-diols) as the soft segments and diphenyl methane diisocyanate (MDI), N,N-bis (2-hydroxyethyl) cinnamamide (BHECA) as the hard segments was synthesized via simple photo-crosslinking of cinnamon groups irradiated under λ > 280 nm ultraviolet (UV) light. Fourier transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance ((1)H-NMR) and ultraviolet-visible absorption spectrum (UV-vis) confirmed the chemical structure of the material. Differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA) results demonstrated that the photo-crosslinked polymer possessed two transition temperatures, one is due to the melting point of the soft segment PCL-diols, and the other is due to the glass transition temperature. All these contributed to the cross-linked structure of the hard segments and resulted in an excellent triple-shape memory effect. Alamar blue assay showed that the material has good non-cytotoxicity and can be potentially used in biomaterial devices.

  11. Predicting muscle forces during the propulsion phase of single leg triple hop test.

    Science.gov (United States)

    Alvim, Felipe Costa; Lucareli, Paulo Roberto Garcia; Menegaldo, Luciano Luporini

    2018-01-01

    Functional biomechanical tests allow the assessment of musculoskeletal system impairments in a simple way. Muscle force synergies associated with movement can provide additional information for diagnosis. However, such forces cannot be directly measured noninvasively. This study aims to estimate muscle activations and forces exerted during the preparation phase of the single leg triple hop test. Two different approaches were tested: static optimization (SO) and computed muscle control (CMC). As an indirect validation, model-estimated muscle activations were compared with surface electromyography (EMG) of selected hip and thigh muscles. Ten physically healthy active women performed a series of jumps, and ground reaction forces, kinematics and EMG data were recorded. An existing OpenSim model with 92 musculotendon actuators was used to estimate muscle forces. Reflective markers data were processed using the OpenSim Inverse Kinematics tool. Residual Reduction Algorithm (RRA) was applied recursively before running the SO and CMC. For both, the same adjusted kinematics were used as inputs. Both approaches presented similar residuals amplitudes. SO showed a closer agreement between the estimated activations and the EMGs of some muscles. Due to inherent EMG methodological limitations, the superiority of SO in relation to CMC can be only hypothesized. It should be confirmed by conducting further studies comparing joint contact forces. The workflow presented in this study can be used to estimate muscle forces during the preparation phase of the single leg triple hop test and allows investigating muscle activation and coordination. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. A Simple Harmonic Universe

    Energy Technology Data Exchange (ETDEWEB)

    Graham, Peter W.; /Stanford U., ITP; Horn, Bart; Kachru, Shamit; /Stanford U., ITP /SLAC; Rajendran, Surjeet; /Johns Hopkins U. /Stanford U., ITP; Torroba, Gonzalo; /Stanford U., ITP /SLAC

    2011-12-14

    We explore simple but novel bouncing solutions of general relativity that avoid singularities. These solutions require curvature k = +1, and are supported by a negative cosmological term and matter with -1 < w < -1 = 3. In the case of moderate bounces (where the ratio of the maximal scale factor a{sub +} to the minimal scale factor a{sub -} is {Omicron}(1)), the solutions are shown to be classically stable and cycle through an infinite set of bounces. For more extreme cases with large a{sub +} = a{sub -}, the solutions can still oscillate many times before classical instabilities take them out of the regime of validity of our approximations. In this regime, quantum particle production also leads eventually to a departure from the realm of validity of semiclassical general relativity, likely yielding a singular crunch. We briefly discuss possible applications of these models to realistic cosmology.

  13. Simple relation algebras

    CERN Document Server

    Givant, Steven

    2017-01-01

    This monograph details several different methods for constructing simple relation algebras, many of which are new with this book. By drawing these seemingly different methods together, all are shown to be aspects of one general approach, for which several applications are given. These tools for constructing and analyzing relation algebras are of particular interest to mathematicians working in logic, algebraic logic, or universal algebra, but will also appeal to philosophers and theoretical computer scientists working in fields that use mathematics. The book is written with a broad audience in mind and features a careful, pedagogical approach; an appendix contains the requisite background material in relation algebras. Over 400 exercises provide ample opportunities to engage with the material, making this a monograph equally appropriate for use in a special topics course or for independent study. Readers interested in pursuing an extended background study of relation algebras will find a comprehensive treatme...

  14. Molecular genetics made simple

    Directory of Open Access Journals (Sweden)

    Heba Sh. Kassem

    2012-07-01

    Full Text Available Genetics have undoubtedly become an integral part of biomedical science and clinical practice, with important implications in deciphering disease pathogenesis and progression, identifying diagnostic and prognostic markers, as well as designing better targeted treatments. The exponential growth of our understanding of different genetic concepts is paralleled by a growing list of genetic terminology that can easily intimidate the unfamiliar reader. Rendering genetics incomprehensible to the clinician however, defeats the very essence of genetic research: its utilization for combating disease and improving quality of life. Herein we attempt to correct this notion by presenting the basic genetic concepts along with their usefulness in the cardiology clinic. Bringing genetics closer to the clinician will enable its harmonious incorporation into clinical care, thus not only restoring our perception of its simple and elegant nature, but importantly ensuring the maximal benefit for our patients.

  15. SIMPLE LIFE AND RELIGION

    Directory of Open Access Journals (Sweden)

    Ahmet YILDIRIM

    2014-07-01

    Full Text Available Individuals in terms of the economy in which we live is one of the most important phenomenon of the century. This phenomenon present itself as the only determinant of people's lives by entering almost makes itself felt. The mo st obvious objective needs of the economy by triggering motive is to induce people to consume . Consumer culture pervades all aspects of the situation are people . Therefore, these people have the blessing of culture , beauty and value all in the name of w hatever is consumed. This is way out of the siege of moral and religious values we have is to go back again . Referred by local cultural and religious values, based on today increasingly come to the fore and the Muslim way of life appears to be close to th e plain / lean preferred by many people life has been a way of life. Even the simple life , a way of life in the Western world , a conception of life , a philosophy, a movement as it has become widely accepted. Here in determining the Muslim way of life Pr ophet. Prophet (sa lived the kind of life a very important model, sample, and determining which direction is known. Religious values, which is the carrier of the prophets, sent to the society they have always been examples and models. Because every aspect of human life, his life style and the surrounding area has a feature. We also value his life that he has unknowingly and without learning and skills and to understand it is not possible to live our religion . We also our presentation, we mainly of Islam o utlook on life and predicted life - style, including the Prophet of Islam 's (sa simple life to scrutinize and lifestyle issues related to reveal , in short Islam's how life has embraced and the Prophet. Prophet's will try to find answers to questions reg arding how to live.

  16. Perturbed dark and singular optical solitons in polarization preserving fibers by modified simple equation method

    Science.gov (United States)

    Yaşar, Emrullah; Yıldırım, Yakup; Zhou, Qin; Moshokoa, Seithuti P.; Ullah, Malik Zaka; Triki, Houria; Biswas, Anjan; Belic, Milivoj

    2017-11-01

    This paper obtains optical soliton solution to perturbed nonlinear Schrödinger's equation by modified simple equation method. There are four types of nonlinear fibers studied in this paper. They are Anti-cubic law, Quadratic-cubic law, Cubic-quintic-septic law and Triple-power law. Dark and singular soliton solutions are derived. Additional solutions such as singular periodic solutions also fall out of the integration scheme.

  17. AAA-DDD triple hydrogen bond complexes.

    Science.gov (United States)

    Blight, Barry A; Camara-Campos, Amaya; Djurdjevic, Smilja; Kaller, Martin; Leigh, David A; McMillan, Fiona M; McNab, Hamish; Slawin, Alexandra M Z

    2009-10-07

    Experiment and theory both suggest that the AAA-DDD pattern of hydrogen bond acceptors (A) and donors (D) is the arrangement of three contiguous hydrogen bonding centers that results in the strongest association between two species. Murray and Zimmerman prepared the first example of such a system (complex 3*2) and determined the lower limit of its association constant (K(a)) in CDCl(3) to be 10(5) M(-1) by (1)H NMR spectroscopy (Murray, T. J. and Zimmerman, S. C. J. Am. Chem. Soc. 1992, 114, 4010-4011). The first cationic AAA-DDD pair (3*4(+)) was described by Bell and Anslyn (Bell, D. A. and Anslyn, E. A. Tetrahedron 1995, 51, 7161-7172), with a K(a) > 5 x 10(5) M(-1) in CH(2)Cl(2) as determined by UV-vis spectroscopy. We were recently able to quantify the strength of a neutral AAA-DDD arrangement using a more chemically stable AAA-DDD system, 6*2, which has an association constant of 2 x 10(7) M(-1) in CH(2)Cl(2) (Djurdjevic, S., Leigh, D. A., McNab, H., Parsons, S., Teobaldi, G. and Zerbetto, F. J. Am. Chem. Soc. 2007, 129, 476-477). Here we report on further AA(A) and DDD partners, together with the first precise measurement of the association constant of a cationic AAA-DDD species. Complex 6*10(+)[B(3,5-(CF(3))(2)C(6)H(3))(4)(-)] has a K(a) = 3 x 10(10) M(-1) at RT in CH(2)Cl(2), by far the most strongly bound triple hydrogen bonded system measured to date. The X-ray crystal structure of 6*10(+) with a BPh(4)(-) counteranion shows a planar array of three short (NH...N distances 1.95-2.15 A), parallel (but staggered rather than strictly linear; N-H...N angles 165.4-168.8 degrees), primary hydrogen bonds. These are apparently reinforced, as theory predicts, by close electrostatic interactions (NH-*-N distances 2.78-3.29 A) between each proton and the acceptor atoms of the adjacent primary hydrogen bonds.

  18. The CALBC RDF Triple Store: retrieval over large literature content

    CERN Document Server

    Croset, Samuel; Li, Chen; Kavaliauskas, Silvestras; Rebholz-Schuhmann, Dietrich

    2010-01-01

    Integration of the scientific literature into a biomedical research infrastructure requires the processing of the literature, identification of the contained named entities (NEs) and concepts, and to represent the content in a standardised way. The CALBC project partners (PPs) have produced a large-scale annotated biomedical corpus with four different semantic groups through the harmonisation of annotations from automatic text mining solutions (Silver Standard Corpus, SSC). The four semantic groups were chemical entities and drugs (CHED), genes and proteins (PRGE), diseases and disorders (DISO) and species (SPE). The content of the SSC has been fully integrated into RDF Triple Store (4,568,678 triples) and has been aligned with content from the GeneAtlas (182,840 triples), UniProtKb (12,552,239 triples for human) and the lexical resource LexEBI (BioLexicon). RDF Triple Store enables querying the scientific literature and bioinformatics resources at the same time for evidence of genetic causes, such as drug ta...

  19. Cross-Linked Collagen Triple Helices by Oxime Ligation.

    Science.gov (United States)

    Hentzen, Nina B; Smeenk, Linde E J; Witek, Jagna; Riniker, Sereina; Wennemers, Helma

    2017-09-13

    Covalent cross-links are crucial for the folding and stability of triple-helical collagen, the most abundant protein in nature. Cross-linking is also an attractive strategy for the development of synthetic collagen-based biocompatible materials. Nature uses interchain disulfide bridges to stabilize collagen trimers. However, their implementation into synthetic collagen is difficult and requires the replacement of the canonical amino acids (4R)-hydroxyproline and proline by cysteine or homocysteine, which reduces the preorganization and thereby stability of collagen triple helices. We therefore explored alternative covalent cross-links that allow for connecting triple-helical collagen via proline residues. Here, we present collagen model peptides that are cross-linked by oxime bonds between 4-aminooxyproline (Aop) and 4-oxoacetamidoproline placed in coplanar Xaa and Yaa positions of neighboring strands. The covalently connected strands folded into hyperstable collagen triple helices (Tm ≈ 80 °C). The design of the cross-links was guided by an analysis of the conformational properties of Aop, studies on the stability and functionalization of Aop-containing collagen triple helices, and molecular dynamics simulations. The studies also show that the aminooxy group exerts a stereoelectronic effect comparable to fluorine and introduce oxime ligation as a tool for the functionalization of synthetic collagen.

  20. Longitudinal Neuropsychological Profile in a Patient with Triple A Syndrome

    Directory of Open Access Journals (Sweden)

    Luigi Mazzone

    2013-01-01

    Full Text Available Triple A syndrome is an autosomal recessive disorder characterized by the triad of adrenocorticotropic hormone resistant adrenal insufficiency, achalasia, and alacrima. Our aim was to describe the neuropsychological characteristics and the cooccurring psychopathological and neurological disorders in an Italian male child suffering from Triple A syndrome at the time of admission (T0 and after one year of follow-up (T1. Many difficulties were observed in the motor domain, as well as in manual dexterity and static/dynamic balance domains of the motor task over time. In sharp contrast with previous literature reports on frequent mild cognitive dysfunction in patients with Triple A syndrome, our child did not show any mental retardation. By contrast, he showed an average IQ at T0 with a slight improvement at T1. To our knowledge, this report is the first describing neuropsychological profile and co-occurring psychopathological problems in a child with Triple A syndrome. Considering that the Triple A syndrome is a progressive disorder which can take years to develop the full-blown clinical picture, these patients require periodical medical controls. Moreover, assessment of neuropsychological and psychopathological features should be performed in patients with this disease, in order to underline the variability of this syndrome.

  1. Development of 600 kV triple resonance pulse transformer.

    Science.gov (United States)

    Li, Mingjia; Zhang, Faqiang; Liang, Chuan; Xu, Zhou

    2015-06-01

    In this paper, a triple-resonance pulse transformer based on an air-core transformer is introduced. The voltage across the high-voltage winding of the air-core transformer is significantly less than the output voltage; instead, the full output voltage appears across the tuning inductor. The maximum ratio of peak load voltage to peak transformer voltage is 2.77 in theory. By analyzing pulse transformer's lossless circuit, the analytical expression for the output voltage and the characteristic equation of the triple-resonance circuit are presented. Design method for the triple-resonance pulse transformer (iterated simulation method) is presented, and a triple-resonance pulse transformer is developed based on the existing air-core transformer. The experimental results indicate that the maximum ratio of peak voltage across the load to peak voltage across the high-voltage winding of the air-core transformer is approximately 2.0 and the peak output voltage of the triple-resonance pulse transformer is approximately 600 kV.

  2. Designing Broadband Access Networks with Triple Redundancy

    DEFF Research Database (Denmark)

    Pedersen, Jens Myrup; Riaz, Muhammad Tahir; Knudsen, Thomas Phillip

    2005-01-01

    provided by some wireless solution. Based on experience with planning Fiber To The Home, the architecture is designed to meet a number of demands, making it practicable and useful in realworld network planning. The proposed wired topology is planar, and suitable for being fitted onto the road network...... without compromising line independency, and it can be implemented stepwise, the first step being based on a simple ring/tree topology. The double ring is used for the distribution network, ensuring 3-connectivity and making it feasible to use for connecting the base stations of the wireless network...

  3. Triple immunofluorescence labeling of atherosclerotic plaque components in apoE/LDLR -/- mice.

    Science.gov (United States)

    Gajda, Mariusz; Jawień, Jacek; Mateuszuk, Lukasz; Lis, Grzegorz J; Radziszewski, Andrzej; Chłopicki, Stefan; Litwin, Jan A

    2008-01-01

    This paper presents a simple and reliable method of triple immunofluorescence staining that allows simultaneous detection of various cell types present in atherosclerotic plaque of apolipoprotein E and LDL receptor-double knockout (apoE/LDLR -/-) mice. We used combined direct and indirect procedures applying commercially available primary antibodies raised in different species to detect smooth muscle cells (Cy3-conjugated mouse anti-smooth muscle actin, SMA), macrophages (rat anti-CD68) and T lymphocytes (rabbit anti-CD3). Fixation of the material in acetone and modified incubation protocol employing nonfat dry milk in preincubation and incubation media significantly increased the intensity of labeling and effectively quenched the background. Our method offers an efficient way to detect qualitative as well as quantitative changes of macrophages, T lymphocytes and smooth muscle cells in atherosclerotic plaque of apoE/LDLR -/- mice during atherosclerosis development or in response to pharmacological treatment.

  4. Triple immunofluorescence labeling of atherosclerotic plaque components in apoE/LDLR -/- mice.

    Directory of Open Access Journals (Sweden)

    Stefan Chłopicki

    2008-06-01

    Full Text Available This paper presents a simple and reliable method of triple immunofluorescence staining that allows simultaneous detection of various cell types present in atherosclerotic plaque of apolipoprotein E and LDL receptor-double knockout (apoE/LDLR -/- mice. We used combined direct and indirect procedures applying commercially available primary antibodies raised in different species to detect smooth muscle cells (Cy3-conjugated mouse anti-smooth muscle actin, SMA, macrophages (rat anti-CD68 and T lymphocytes (rabbit anti-CD3. Fixation of the material in acetone and modified incubation protocol employing nonfat dry milk in preincubation and incubation media significantly increased the intensity of labeling and effectively quenched the background. Our method offers an efficient way to detect qualitative as well as quantitative changes of macrophages, T lymphocytes and smooth muscle cells in atherosclerotic plaque of apoE/LDLR -/- mice during atherosclerosis development or in response to pharmacological treatment.

  5. Clinical observation on the treatment of glaucoma with cataract through triple surgery

    Directory of Open Access Journals (Sweden)

    Dan Yu

    2014-04-01

    Full Text Available AIM: To observe the therapeutic effect of triple surgery in the treatment of glaucoma with cataract at different stages.METHODS: Totally 31 patients(55 eyeswith glaucoma and cataract were treated with phacoemulsification, lens implantation and trabeculectomy. Preoperation and postoperation of visual acuity, intraocular pressure, filtering bleb and postoperation complications were observed.RESULTS: After 6mo postoperation, the vision was significantly improved. The intraocular pressure was controlled in normal range and filtering bleb was good. There was a little complications after operation.CONCLUSION: Phacoemulsification intraocular lens implantation with anti-glaucoma establishes new aqueous humor outflow. It can effectively decrease intraocular pressure, deepen anterior chamber and improve vision, reduce all kinds of complications after simple glaucoma surgery.

  6. Triple differential cross sections for the ionization of formic acid by electron impact

    Science.gov (United States)

    Mouawad, L.; Hervieux, P. A.; Dal Cappello, C.; Pansanel, J.; Osman, A.; Khalil, M.; El Bitar, Z.

    2017-11-01

    Theoretical triple differential cross sections for the simple ionization of the two outermost valence orbitals of formic acid monomer are given in this work. The first Born approximation is used to describe the collision dynamics with one Coulomb wave function for the ejected electron. Single-center molecular wave functions are generated using the Gaussian 09 program. The cross sections are calculated for an average molecular orientation with the proper average method. The results show that the proposed framework provides better agreement with experimental data than the previously used orientation averaged molecular orbital approximation. Consequently, this work shows the importance of performing the orientation averaging on the cross sections and not on the molecular wave functions. It also provides a methodology that reduces the complexity of calculations while maintaining a good quality of the results.

  7. The influence of triple bottom line on international operations management

    Directory of Open Access Journals (Sweden)

    Francisco Sperotto Flores

    2017-12-01

    Full Text Available This paper takes a triple bottom line perspective to analyze how the international operations literature integrates economic, social, and environmental issues. Additionally, it shows the main drivers of and barriers to the adoption of triple bottom line practices by companies in an international context. We conducted a literature review in English language journals which publish research of production and operations management and sustainability, resulting in a final sample of 29 papers. Results show that social and legal pressure for companies to adopt a responsible behavior prompts an isomorphic process that leads them to conduct their operations on behalf of triple bottom line goals. Behavioral differences between spin-offs in various countries caused institutions to create mechanisms that can press and change private standards through regulation and enforcement. There is room for progress in studies that seek to analyze the company’s relationships in its international experience and its multi-institutional relations.

  8. Triple photons: a challenge in nonlinear and quantum optics

    Science.gov (United States)

    Bencheikh, Kamel; Gravier, Fabien; Douady, Julien; Levenson, Ariel; Boulanger, Benoît

    2007-03-01

    This article is devoted to the generation and the quantum correlations of triple photons, which correspond to the creation of three highly correlated photons from the splitting of a single photon by a phase-matched third-order parametric nonlinear process. These triples constitute a Greenberger-Horne-Zeilinger state of light and are interesting from a fundamental point of view but also for new schemes of quantum cryptography. We give here the classical and quantum descriptions of triple photon generation, we report on the first experimental demonstration of such a generation, and we calculate the Wigner function of three-photon quantum states of light. To cite this article: K. Bencheikh et al., C. R. Physique 8 (2007).

  9. A microelectromechanical systems-enabled, miniature triple quadrupole mass spectrometer.

    Science.gov (United States)

    Wright, Steven; Malcolm, Andrew; Wright, Christopher; O'Prey, Shane; Crichton, Edward; Dash, Neil; Moseley, Richard W; Zaczek, Wojciech; Edwards, Peter; Fussell, Richard J; Syms, Richard R A

    2015-03-17

    Miniaturized mass spectrometers are becoming increasingly capable, enabling the development of many novel field and laboratory applications. However, to date, triple quadrupole tandem mass spectrometers, the workhorses of quantitative analysis, have not been significantly reduced in size. Here, the basis of a field-deployable triple quadrupole is described. The key development is a highly miniaturized ion optical assembly in which a sequence of six microengineered components is employed to generate ions at atmospheric pressure, provide a vacuum interface, effect ion guiding, and perform fragmentation and mass analysis. Despite its small dimensions, the collision cell efficiently fragments precursor ions and yields product ion spectra that are very similar to those recorded using conventional instruments. The miniature triple quadrupole has been used to detect thiabendazole, a common pesticide, in apples at a level of 10 ng/g.

  10. Simultaneous determination of triple therapy for Helicobacter pylori in human plasma by reversed phase chromatography with online wavelength switching

    Science.gov (United States)

    Ahmed, Sameh; Atia, Noha N.

    2015-02-01

    The infection of gastric mucosa by Helicobacter pylori (HP) is an essential cofactor in the aetiology of gastroduodenal ulcer and gastric carcinoma. Because of the bacterial resistance, combination therapy containing omeprazole (OME), tinidazole (TNZ) and clarithromycin (CLA) is commonly used for eradication of HP. However, the simultaneous determination of the triple therapy in human plasma was not reported. A simple, reproducible, and selective HPLC method was developed for the simultaneous determination of the triple therapy mixture used for management of HP infections in human plasma. An HPLC procedure based on a liquid-liquid extraction, enrichment of the analytes and subsequent reversed-phase chromatography with UV detection was used. To enable sensitive and selective detection, the method involved the use of online wavelength switching detection, with two different detection wavelengths; 280 nm for detection of OME and TNZ and 210 nm for detection of CLA. Separations were performed on C18 analytical column with acetonitrile-10 mM phosphate buffer of pH = 3.0 at flow rate of 1.0 mL min-1. The linear ranges in human plasma were 0.05-10 μg mL-1 with correlation coefficients >0.9990. The detection limits in human plasma were 0.02-0.07 μg mL-1. Validation parameters were assessed in compliance with US-FDA guidelines. The method proved to be valuable for the therapeutic drug monitoring after oral administration of triple therapy tablets.

  11. Entropy Is Simple, Qualitatively

    Science.gov (United States)

    Lambert, Frank L.

    2002-10-01

    Qualitatively, entropy is simple. What it is, why it is useful in understanding the behavior of macro systems or of molecular systems is easy to state: Entropy increase from a macro viewpoint is a measure of the dispersal of energy from localized to spread out at a temperature T. The conventional q in qrev/T is the energy dispersed to or from a substance or a system. On a molecular basis, entropy increase means that a system changes from having fewer accessible microstates to having a larger number of accessible microstates. Fundamentally based on statistical and quantum mechanics, this approach is superior to the non-fundamental "disorder" as a descriptor of entropy change. The foregoing in no way denies the subtlety or the difficulty presented by entropy in thermodynamics—to first-year students or to professionals. However, as an aid to beginners in their quantitative study of thermodynamics, the qualitative conclusions in this article give students the advantage of a clear bird’s-eye view of why entropy increases in a wide variety of basic cases: a substance going from 0 K to T, phase change, gas expansion, mixing of ideal gases or liquids, colligative effects, and the Gibbs equation. See Letter re: this article.

  12. A Simple Accelerometer Calibrator

    Science.gov (United States)

    Salam, R. A.; Islamy, M. R. F.; Munir, M. M.; Latief, H.; Irsyam, M.; Khairurrijal

    2016-08-01

    High possibility of earthquake could lead to the high number of victims caused by it. It also can cause other hazards such as tsunami, landslide, etc. In that case it requires a system that can examine the earthquake occurrence. Some possible system to detect earthquake is by creating a vibration sensor system using accelerometer. However, the output of the system is usually put in the form of acceleration data. Therefore, a calibrator system for accelerometer to sense the vibration is needed. In this study, a simple accelerometer calibrator has been developed using 12 V DC motor, optocoupler, Liquid Crystal Display (LCD) and AVR 328 microcontroller as controller system. The system uses the Pulse Wave Modulation (PWM) form microcontroller to control the motor rotational speed as response to vibration frequency. The frequency of vibration was read by optocoupler and then those data was used as feedback to the system. The results show that the systems could control the rotational speed and the vibration frequencies in accordance with the defined PWM.

  13. Quasispecies made simple.

    Directory of Open Access Journals (Sweden)

    J J Bull

    2005-11-01

    Full Text Available Quasispecies are clouds of genotypes that appear in a population at mutation-selection balance. This concept has recently attracted the attention of virologists, because many RNA viruses appear to generate high levels of genetic variation that may enhance the evolution of drug resistance and immune escape. The literature on these important evolutionary processes is, however, quite challenging. Here we use simple models to link mutation-selection balance theory to the most novel property of quasispecies: the error threshold-a mutation rate below which populations equilibrate in a traditional mutation-selection balance and above which the population experiences an error catastrophe, that is, the loss of the favored genotype through frequent deleterious mutations. These models show that a single fitness landscape may contain multiple, hierarchically organized error thresholds and that an error threshold is affected by the extent of back mutation and redundancy in the genotype-to-phenotype map. Importantly, an error threshold is distinct from an extinction threshold, which is the complete loss of the population through lethal mutations. Based on this framework, we argue that the lethal mutagenesis of a viral infection by mutation-inducing drugs is not a true error catastophe, but is an extinction catastrophe.

  14. The evolution of hierarchical triple star-systems

    Science.gov (United States)

    Toonen, Silvia; Hamers, Adrian; Portegies Zwart, Simon

    2016-12-01

    Field stars are frequently formed in pairs, and many of these binaries are part of triples or even higher-order systems. Even though, the principles of single stellar evolution and binary evolution, have been accepted for a long time, the long-term evolution of stellar triples is poorly understood. The presence of a third star in an orbit around a binary system can significantly alter the evolution of those stars and the binary system. The rich dynamical behaviour in three-body systems can give rise to Lidov-Kozai cycles, in which the eccentricity of the inner orbit and the inclination between the inner and outer orbit vary periodically. In turn, this can lead to an enhancement of tidal effects (tidal friction), gravitational-wave emission and stellar interactions such as mass transfer and collisions. The lack of a self-consistent treatment of triple evolution, including both three-body dynamics as well as stellar evolution, hinders the systematic study and general understanding of the long-term evolution of triple systems. In this paper, we aim to address some of these hiatus, by discussing the dominant physical processes of hierarchical triple evolution, and presenting heuristic recipes for these processes. To improve our understanding on hierarchical stellar triples, these descriptions are implemented in a public source code TrES, which combines three-body dynamics (based on the secular approach) with stellar evolution and their mutual influences. Note that modelling through a phase of stable mass transfer in an eccentric orbit is currently not implemented in TrES, but can be implemented with the appropriate methodology at a later stage.

  15. Steam Driven Triple Effect Absorption Solar Cooling System

    OpenAIRE

    Yabase, Hajime; Makita, Kazuyuki

    2012-01-01

    The authors propose a solar cooling system employing a steam-driven triple effect absorption chiller as a new technique for saving CO2 emission in the air conditioning field. The absorption chiller is a cooling machine using thermal energy as a drive source, and it is ideal for utilizing solar heat. In addition, by employing a triple effect absorption chiller of high efficiency, a high energy saving effect and a significant CO2 saving effect can be expected. As a result of studies, it has bee...

  16. Non-resonant triple alpha reaction rate at low temperature

    Energy Technology Data Exchange (ETDEWEB)

    Itoh, T.; Tamii, A.; Aoi, N.; Fujita, H.; Hashimoto, T.; Miki, K.; Ogata, K. [Research Center for Nuclear Physics, Osaka University, Ibaraki, Osaka 567-0047 (Japan); Carter, J.; Donaldson, L.; Sideras-Haddad, E. [Schools of Physics, University of Witwatersrand, Johannesburg 2050 (South Africa); Furuno, T.; Kawabata, T. [Departments of Physics, Kyoto University, Sakyo, Kyoto, 606-8502 (Japan); Kamimura, M. [RIKEN Nishina Center, Wako, Saitama, 351-0198 (Japan); Nemulodi, F.; Neveling, R.; Smit, F. D.; Swarts, C. [iThemba Laboratory for Accelerator Based Sciences Somerset, West, 7129 (South Africa)

    2014-05-02

    Our experimental goal is to study the non-resonant triple alpha reaction rate at low temperture (T < 10{sup 8} K). The {sup 13}C(p,d) reaction at 66 MeV has been used to probe the alpha-unbound continuum state in {sup 12}C just below the 2{sup nd} 0{sup +} state at 7.65 MeV. The transition strength to the continuum state is predicted to be sensitive to the non-resonant triple alpha reaction rate. The experiment has been performed at iThemba LABS. We report the present status of the experiment.

  17. Triple pelvic osteotomy in the treatment of hip dysplasia

    Directory of Open Access Journals (Sweden)

    Vukašinović Zoran

    2009-01-01

    Full Text Available Introduction. Insufficient femoral head coverage is found in a variety of diseases, with acetabular dysplasia as the most frequent disorder and triple pelvic osteotomy as the most recently introduced surgical treatment. Objective. This study analyses pre- and postoperative pathoanatomic characteristics of triple in comparison to Salter and Chiari osteotomies, with a logistic regression analysis of outcome predictor and effect explanator factors in relation to the chosen type of operation. Methods. The study involved 136 adolescents treated with Salter and Chiari osteotomies or a triple pelvic osteotomy at the Institute of Orthopaedic Surgery 'Banjica' in Belgrade. The patients were between 10-20 years old at the time of operation. We collected and analyzed data from all the patients: illness history, operative parameters, preoperative and postoperative pathoanatomic data. The data was statistically processed using the statistical software SPSS, defining standard descriptive values, and by using the appropriate tests of analytic statistics: t-test for dependent and independent variables, χ2-test, Fisher's exact test, Wilcoxon's test, parameter correlation, one-way ANOVA, multi-factorial ANOVA and logistic regression, according to the type of the analyzed data and the conditions under which the statistical methods were applied. Results. The average CE angle after triple pelvic osteotomy was 43.5°, more improved than after the Salter osteotomy (33.0° and Chiari osteotomy (31.4° (F=16.822; p<0.01. Postoperative spherical congruence was also more frequent after the triple osteotomy than after the other two types of operations, and with a high significance. Preoperative painful discomfort was found to be a valid predictor of indications for the triple osteotomy over both Chiari and Salter osteotomies. The valid explanators of effect for the triple osteotomy are: postoperative joint congruence (compared to the Chiari osteotomy and increase in joint

  18. Quaternary Evolution of Karliova Triple Junction

    Science.gov (United States)

    Sançar, Taylan; Zabcı, Cengiz; Akyüz, H. Serdar

    2013-04-01

    The arguments to explain Quaternary evolution of Karlıova Triple Junction (KTJ) depends upon two different analogue models. The compressional type of Prandtl Cell Model (PCM) and 60 km wide shear zone with concomitant counter clockwise block rotation used to modelled for west and east of the KTJ respectively. The data for the model of west of the KTJ acquired by extensive field studies, and quantified geomorphic features. Compressional PCM put forward that behavior of slip lines controlled by boundary faults. But the model is not enough to explain slip distribution, age relation of them. At west of the KTJ boundary faults presented by eastern most segments of the North Anatolian Fault Zone (NAFZ) and the East Anatolian Fault Zone (EAFZ). Slip lines, however, presented by Bahçeli and Toklular faults. Both field studies and morphometric analyses undisputedly set forth that there are two different fault types between the NAFZ and EAFZ. The most strain loaded fault type, which are positioned near the NAFZ, start as a strike-slip fault and when it turn to SE its sense of motion change to oblique normal due to changing orientation of principal stress axes. The new orientation of stress axes exposed in the field as a special kind of caprock -cuesta-. The younger slip lines formed very close to junction point and accommodate less slip. Even though slip trajectories started from the boundary faults in compressional PCM, at the west of KTJ, right lateral trajectories more clearly formed close the NAFZ and left lateral trajectories, relatively less strain loaded fault type, are poorly formed close the EAFZ . We think that, this differences between KTJ and compressional PCM result from the distinction of velocity of boundary faults. East of the KTJ governed by completely different mechanism. The region controlled two main fault systems. The Varto Fault Zone (VFZ), the eastern branch of the KTJ, and Murat Fault (MF) delimited the region from north and south respectively. The

  19. Platinum complexes having redox-active PPh2C[triple bond]CFc and/or C[triple bond]CFc as terminal or bridging ligands.

    Science.gov (United States)

    Díez, Alvaro; Lalinde, Elena; Teresa Moreno, M; Sánchez, Sergio

    2009-05-14

    A series of heteronuclear-Pt(ii) complexes containing ferrocenylethynyl units linked directly (Pt-C[triple bond]CFc) or through a phosphorous atom (Pt-PPh(2)C[triple bond]CFc) to the platinum center is reported. The reaction of derivative [cis-Pt(R(F))(2)(PPh(2)C[triple bond]CFc)(2)] (R(F) = C(6)F(5)) with the solvate complex [cis-Pt(R(F))(2)(thf)(2)] leads to the formation of an asymmetrical heteronuclear diplatinum complex [{Pt(R(F))(2)(mu-1kappaP:2eta(2)-PPh(2)C[triple bond]CFc)(2)}Pt(R(F))(2)] having the "cis-Pt(R(F))(2)" fragment coordinated to the triple bonds of both ferrocenylethynylphosphine units, while treatment of [cis-Pt(C[triple bond]CFc)(2)(PPh(2)C[triple bond]CR)(2)] (R = Fc , Ph , tBu ) with the same solvate [cis-Pt(R(F))(2)(thf)(2)], affords double ferrocenylacetylide-bridged diplatinum systems [{Pt(PPh(2)C[triple bond]CR)(2)(mu-eta(1):eta(2)-C[triple bond]CFc)(2)}Pt(R(F))(2)] . The solid-state structures of [cis/trans-Pt(R(F))(2)(PPh(2)C[triple bond]CFc)(2)] /, [cis-Pt(R(F))(2)(PPh(2)C[triple bond]CFc)(tht)] (tht = tetrahydrothiophene), [{Pt(R(F))(2)(mu-1kappaP:2eta(2)-PPh(2)C[triple bond]CFc)(2)}Pt(R(F))(2)] and [{Pt(PPh(2)C[triple bond]CtBu)(2)(mu-eta(1):eta(2)-C[triple bond]CFc)(2)}Pt(R(F))(2)] have been determined by X-ray diffraction methods. The electronic spectra and the electrochemical behaviour of all monoplatinum derivatives are discussed, showing a different extent of interaction between the remote ferrocenyl groups when they belong to PPh(2)C[triple bond]CFc or C[triple bond]CFc ligands. For the diplatinum systems and , containing bridging (kappaP:eta(2)-PPh(2)C[triple bond]CFc ) or (eta(1):eta(2)-C[triple bond, length as m-dash]CFc ) ligands, their electrochemical properties were also compared with the parent precursors.

  20. A Lagrangian framework for deriving triples and quadruples corrections to the CCSD energy

    DEFF Research Database (Denmark)

    Eriksen, Janus Juul; Kristensen, Kasper; Kjærgaard, Thomas

    2014-01-01

    Using the coupled cluster Lagrangian technique, we have determined perturbative corrections to the coupled cluster singles and doubles (CCSD) energy that converge towards the coupled cluster singles, doubles, and triples (CCSDT) and coupled cluster singles, doubles, triples, and quadruples (CCSDT...

  1. Una historia muy simple

    Directory of Open Access Journals (Sweden)

    Miha Mazzini

    2009-12-01

    Full Text Available Voy a contarles una historia muy simple. Probablemente no les parecerá nada espe- cial y no quiero robarles tiempo, así que voy a tratar de hacerlo lo más rápido posible. Me inscribí en psicología porque eso hizo mi mejor amiga. Éramos compañeras desde jardín de infantes y siempre la seguí en todo. En tercer año de facultad conoció a su novio y continuó sus estudios en otro país; por primera vez no podía seguirla. Cuando rendí todos los exámenes, el profesor me preguntó si estaba interesada en hacer mi tesis sobre el perfil psicológico de los participantes de reality shows. Accedí para no tener que pensar en otro tema, aunque no veía mucho la televisión porque me pasaba las noches entre los libros de estudio. Enseguida me di cuenta de que, evidentemente, el profesor había firmado un contrato con la emisora: a él lo empleaban y y yo era la que iba a tener que trabajar, pero no me importaba. La tesis de licenciatura no es más que eso y hay que hacerla. Yo evaluaba los candidatos y elegía a los participantes que vivirían juntos duran- te algunos meses. Como hacían el programa con una licencia extranjera y ya sabían qué le interesaba a la audiencia, yo tenía preparados los rasgos de los perfiles psicológicos que en ese aislamiento colectivo no resultan bien. Tuve que elegir gente variada, pero dentro de la media; nunca nada verdaderamente especial. Cuando me gradué, tuve las noches libres: de pronto tenía mucho más tiempo y podía haber visto el programa, pero ya había terminado. Pero oí que había sido todo un éxito y que sobre todo a los chicos les había encantado el reality y los participantes elegidos.

  2. Organizing product innovation: hierarchy, market or triple-helix networks?

    Science.gov (United States)

    Fitjar, Rune Dahl; Gjelsvik, Martin; Rodríguez-Pose, Andrés

    This paper assesses the extent to which the organization of the innovation effort in firms, as well as the geographical scale at which this effort is pursued, affects the capacity to benefit from product innovations. Three alternative modes of organization are studied: hierarchy, market and triple-helix-type networks. Furthermore, we consider triple-helix networks at three geographical scales: local, national and international. These relationships are tested on a random sample of 763 firms located in five urban regions of Norway which reported having introduced new products or services during the preceding 3 years. The analysis shows that firms exploiting internal hierarchy or triple-helix networks with a wide range of partners managed to derive a significantly higher share of their income from new products, compared to those that mainly relied on outsourcing within the market. In addition, the analysis shows that the geographical scale of cooperation in networks, as well as the type of partner used, matters for the capacity of firms to benefit from product innovation. In particular, firms that collaborate in international triple-helix-type networks involving suppliers, customers and R&D institutions extract a higher share of their income from product innovations, regardless of whether they organize the processes internally or through the network.

  3. Triple A syndrome presenting with myopathy: An Egyptian patient ...

    African Journals Online (AJOL)

    In this paper we report a 13 year old boy with Allgrove syndrome presenting with muscular weakness that was confi rmed by EMG studies. To our knowledge, muscle disease in Allogrove syndrome was not reported before. Keywords: Allgrove syndrome, triple A syndrome, alacrmia, cardiac achalasia, adrenal insufficiency.

  4. Assembly of Liposomes Controlled by Triple Helix Formation

    DEFF Research Database (Denmark)

    Vogel, Stefan; Jakobsen, Ulla

    2013-01-01

    sequences (G or C-rich) to explore the applicability of the method for different triple helical assembly modes. We demonstrate advantages and limitations of the approach and proof the reversible and reproducible formation of liposome aggregates during thermal denaturation cycles. Nanoparticle tracking...

  5. [Computer tomography image of a triple anlage of the stomach].

    Science.gov (United States)

    Fischer, H J; Becker, W

    1983-12-01

    A triple stomach in a 22 year old patient was evaluated by CT. In addition to the main stomach two cystic formations containing gastric mucosa were found. These accessory stomachs did not fill following ingestion of oral contrast medium. In the CT diagnosis of cystic masses of the upper abdomen multiple gastric formations should be considered.

  6. A triple negative breast cancer: what it is not!

    Directory of Open Access Journals (Sweden)

    Katakkar SB

    2012-02-01

    Full Text Available Suresh B KatakkarRegional Medical Oncology Hematology Leader, Centre for the North, BC Cancer Agency, Prince George, British Columbia, CanadaAbstract: The triple negative cancer is an unusual, and at the same time, a unique entity where the discordance rate is almost 18%. That means 18% of Her2 negative results will transform into a Her2 positive status and will have the affinity to spread to the central nervous system (CNS. With the identification of CD44, CD24, and ALDH1, we may be able to determine which group of triple negative breast cancer patients will have CNS metastasis. This case illustrates the Her2 expressing cells have higher CNS affinity. As the original tumor was Her2 negative, if a genomic assay was then done on this patient, we would have identified the potential of CNS involvement. In conclusion, genomic assays should be routinely done on triple negative cancers.Keywords: triple negative, breast cancer, claudin high or low, genomic microassay

  7. Triple negative breast cancer: the role of metabolic pathways.

    Science.gov (United States)

    Dean, S J R; Rhodes, A

    2014-12-01

    The incidence of breast cancer in Malaysia and other Asian countries is on the increase, reflecting lifestyle changes some of which are known risk factors for the development of breast cancer. Most breast cancers are amenable to adjuvant therapies that target hormone receptors or HER2 receptors on the surface of the cancer cells and bring about significant improvement in survival. However, approximately 17% of Malaysian women with breast cancer, present with tumours that are devoid of these receptors and are consequently termed 'triple negative' breast cancers. These triple negative breast cancers typically occur in women of a younger age than receptor positive cancers, are predominantly of high grade tumours and the prognosis is usually poor. There is therefore a pressing need to understand the biological pathways that drive these tumours, in order that effective strategies are developed to treat these aggressive tumours. With the increasing affluence of developing countries, obesity and Type II Diabetes are also on the rise. These diseases are associated with an increased risk of developing a range of cancers including those of the breast. In particular, the metabolic syndrome has been shown to be associated with triple negative breast cancer. This article reviews some of the metabolic pathways and biomarkers which have been shown to be aberrantly expressed in triple negative breast cancer and highlights some of the ongoing work in this area.

  8. Quality of the spare triple-GEM detectors

    CERN Document Server

    Lenci, Rosario; Paoletti, Emiliano; Pasquali, Luigi; Pinci, Davide; Piscitelli, Carmelo; Poli Lener, Marco; Sciubba, Adalberto; Tskhadadze, Edisher

    2017-01-01

    Triple-GEM chambers equip the inner region of the M1 muon station. In order to provide spare detectors in case of problems in the operating ones, new chambers have been assembled at the Frascati National Laboratories of the INFN. This note summarizes the results of the quality tests performed at the end of the production procedure.

  9. Peptide tessellation yields micrometre-scale collagen triple helices

    Science.gov (United States)

    Tanrikulu, I. Caglar; Forticaux, Audrey; Jin, Song; Raines, Ronald T.

    2016-11-01

    Sticky-ended DNA duplexes can associate spontaneously into long double helices; however, such self-assembly is much less developed with proteins. Collagen is the most prevalent component of the extracellular matrix and a common clinical biomaterial. As for natural DNA, the ~103-residue triple helices (~300 nm) of natural collagen are recalcitrant to chemical synthesis. Here we show how the self-assembly of short collagen-mimetic peptides (CMPs) can enable the fabrication of synthetic collagen triple helices that are nearly a micrometre in length. Inspired by the mathematics of tessellations, we derive rules for the design of single CMPs that self-assemble into long triple helices with perfect symmetry. Sticky ends thus created are uniform across the assembly and drive its growth. Enacting this design yields individual triple helices that, in length, match or exceed those in natural collagen and are remarkably thermostable, despite the absence of higher-order association. The symmetric assembly of CMPs provides an enabling platform for the development of advanced materials for medicine and nanotechnology.

  10. Mutant WD-repeat protein in triple-A syndrome.

    Science.gov (United States)

    Tullio-Pelet, A; Salomon, R; Hadj-Rabia, S; Mugnier, C; de Laet, M H; Chaouachi, B; Bakiri, F; Brottier, P; Cattolico, L; Penet, C; Bégeot, M; Naville, D; Nicolino, M; Chaussain, J L; Weissenbach, J; Munnich, A; Lyonnet, S

    2000-11-01

    Triple-A syndrome (MIM 231550; also known as Allgrove syndrome) is an autosomal recessive disorder characterized by adrenocorticotropin hormone (ACTH)-resistant adrenal insufficiency, achalasia of the oesophageal cardia and alacrima. Whereas several lines of evidence indicate that triple-A syndrome results from the abnormal development of the autonomic nervous system, late-onset progressive neurological symptoms (including cerebellar ataxia, peripheral neuropathy and mild dementia) suggest that the central nervous system may be involved in the disease as well. Using fine-mapping based on linkage disequilibrium in North African inbred families, we identified a short ancestral haplotype on chromosome 12q13 (<1 cM), sequenced a BAC contig encompassing the triple-A minimal region and identified a novel gene (AAAS) encoding a protein of 547 amino acids that is mutant in affected individuals. We found five homozygous truncating mutations in unrelated patients and ascribed the founder effect in North African families to a single splice-donor site mutation that occurred more than 2,400 years ago. The predicted product of AAAS, ALADIN (for alacrima-achalasia-adrenal insufficiency neurologic disorder), belongs to the WD-repeat family of regulatory proteins, indicating a new disease mechanism involved in triple-A syndrome. The expression of the gene in both neuroendocrine and cerebral structures points to a role in the normal development of the peripheral and central nervous systems.

  11. Co-innovatie Triple P: integratie van marketingstrategie en personeelsbeleid

    NARCIS (Netherlands)

    Bartels, J.; Hendriks, R.; Ruyter, de P.; Zeelenberg, A.; Engelsman, V.; Eichelsheim, C.; Skoppek, H.; Schmidt, M.

    2008-01-01

    This project focuses on the integration of Triple P in marketing and personnel policy. The aim of the project is as follows: “How can you effectively use the intrinsic values of sustainable agriculture and corporate social responsibility in the marketing of organic fruit and vegetables?” In the

  12. Values and Youth Care Interventions: The Case of Triple P

    NARCIS (Netherlands)

    Hopman, Marit|info:eu-repo/dai/nl/314013377; de Winter, Micha; Koops, Willem|info:eu-repo/dai/nl/069037744

    2014-01-01

    Our investigation turns the attention to the unspoken values and beliefs of a preventive intervention, namely Triple P. Currently, the child-care system is dominated by an emphasis on preventive and early interventions. In the Netherlands specifically, the former Ministry of Youth and Family

  13. The Triple Helix Model and the Knowledge-Based Economy

    NARCIS (Netherlands)

    Leydesdorff, L.; Meyer, M.

    2010-01-01

    The Triple Helix model of university-industry-government relations can be generalized from a neo-institutional model of networks of relations to a neo-evolutionary model of how three selection environments operate upon one another. Two selection mechanisms operating upon each other can mutually

  14. Triple Pulse Tester - Efficient Power Loss Characterization of Power Modules

    DEFF Research Database (Denmark)

    Trintis, Ionut; Poulsen, Thomas; Beczkowski, Szymon

    2015-01-01

    In this paper the triple pulse testing method and circuit for power loss characterization of power modules is introduced. The proposed test platform is able to accurately characterize both the switching and conduction losses of power modules in a single automated process. A configuration of a hal...

  15. Subtalar versus triple arthrodesis after intra-articular calcaneal fractures

    NARCIS (Netherlands)

    Schepers, Tim; Kieboom, Brenda C. T.; Bessems, Gert H. J. M.; Vogels, Lucas M. M.; van Lieshout, Esther M. M.; Patka, Peter

    2010-01-01

    Depending upon initial treatment, between 2 and 30% of patients with a displaced intra-articular calcaneal fracture require a secondary arthrodesis. The aim of this study was to investigate the effect of subtalar versus triple arthrodesis on functional outcome. A total of 33 patients with 37

  16. Subtalar versus triple arthrodesis after intra-articular calcaneal fractures

    NARCIS (Netherlands)

    T. Schepers (Tim); B.C.T. Kieboom (Brenda); J.H.J.M. Bessems (Gert); L.M.M. Vogels (Lucas); E.M.M. van Lieshout (Esther); P. Patka (Peter)

    2010-01-01

    textabstractDepending upon initial treatment, between 2 and 30% of patients with a displaced intra-articular calcaneal fracture require a secondary arthrodesis. The aim of this study was to investigate the effect of subtalar versus triple arthrodesis on functional outcome. A total of 33 patients

  17. Pursuing the Triple Aim: The First 7 Years.

    Science.gov (United States)

    Whittington, John W; Nolan, Kevin; Lewis, Ninon; Torres, Trissa

    2015-06-01

    POLICY POINTS: In 2008, researchers at the Institute for Healthcare Improvement (IHI) proposed the Triple Aim, strategic organizing principles for health care organizations and geographic communities that seek, simultaneously, to improve the individual experience of care and the health of populations and to reduce the per capita costs of care for populations. In 2010, the Triple Aim became part of the US national strategy for tackling health care issues, especially in the implementation of the Patient Protection and Affordable Care Act (ACA) of 2010. Since that time, IHI and others have worked together to determine how the implementation of the Triple Aim has progressed. Drawing on our 7 years of experience, we describe 3 major principles that guided the organizations and communities working on this endeavor: creating the right foundation for population management, managing services at scale for the population, and establishing a learning system to drive and sustain the work over time. In 2008, researchers at the Institute for Healthcare Improvement (IHI) described the Triple Aim as simultaneously "improving the individual experience of care; improving the health of populations; and reducing the per capita costs of care for populations." IHI and its close colleagues had determined that both individual and societal changes were needed. In 2007, IHI began recruiting organizations from around the world to participate in a collaborative to implement what became known as the Triple Aim. The 141 participating organizations included health care systems, hospitals, health care insurance companies, and others closely tied to health care. In addition, key groups outside the health care system were represented, such as public health agencies, social services groups, and community coalitions. This collaborative provided a structure for observational research. By noting the contrasts between the contexts and structures of those sites in the collaborative that progressed and

  18. 19p13.1 is a triple-negative-specific breast cancer susceptibility locus

    DEFF Research Database (Denmark)

    Stevens, Kristen N; Fredericksen, Zachary; Vachon, Celine M

    2012-01-01

    -negative breast cancer risk when triple-negative cases were excluded (OR, 0.98; 95% CI, 0.89-1.07; P = 0.62). In addition, a combined analysis of triple-negative cases from BCAC and the Triple Negative Breast Cancer Consortium (TNBCC; N = 3,566) identified a genome-wide significant association between rs8170...

  19. Effectiviteit van Triple P in Nederland: stand van zaken en controverse

    NARCIS (Netherlands)

    Schappin, R|info:eu-repo/dai/nl/341014311; de Graaf, Ireen; Reijneveld, S.A.

    Objective: The Triple P – Positive Parenting Program is available in over 50% of the Dutch municipalities. In this article we summarize the effects of Triple P as found in international meta-analyses and Dutch research. We also discuss the controversy surrounding Triple P. Method: We systematically

  20. One-step fabrication of triple-layered microcapsules by a tri-axial flow focusing device for microencapsulation of soluble drugs and imaging agents

    Science.gov (United States)

    Yuan, Shuai; Wu, Qiang; Lei, Fan; Li, Guangbin; Si, Ting; Xu, Ronald X.

    2016-04-01

    In this work, the microencapsulation of water-soluble drug (doxorubicin, Dox) and imaging agent (perfluorocarbon, PFC) is performed by a novel liquid driven tri-axial flow focusing (LDTFF) device. The formation of stable triple-layered cone-jet mode can be observed in the simple well-assembled LDTFF device, providing an easy approach to fabricate mono-disperse triple-layered microcapsules with high encapsulation efficiency, high throughput and low cost in just one step. The fluorescence images show that the microcapsules have a satisfactory core-shell structure. The SEM micrographs show spherical and smooth surface views of the triple-layered microcapsules after being stirred 72h to remove the organic solvent totally. The results of thermo-responsive release experiments of the produced triple-layered microcapsules show these multifunctional capsules can be well stimulated when the environment temperature is beyond 55 degree centigrade. In a word, this novel approach has a great potential in applications such as drug delivery and image-guided therapy.

  1. Strategic Clinical Networks: Alberta's Response to Triple Aim.

    Science.gov (United States)

    Noseworthy, Tom; Wasylak, Tracy; O'Neill, Blair J

    2016-01-01

    Verma and Bhatia make a compelling case for the Triple Aim to promote health system innovation and sustainability. We concur. Moreover, the authors offer a useful categorization of policies and actions to advance the Triple Aim under the "classic functions" of financing, stewardship and resource generation (Verma and Bhatia 2016). The argument is tendered that provincial governments should embrace the Triple Aim in the absence of federal government leadership, noting that, by international standards, we are at best mediocre and, more realistically, fighting for the bottom in comparative, annual cross-country surveys. Ignoring federal government participation in Medicare and resorting solely to provincial leadership seems to make sense for the purposes of this discourse; but, it makes no sense at all if we are attempting to achieve high performance in Canada's non-system (Canada Health Action: Building on the Legacy 1997; Commission on the Future of Health Care in Canada 2002; Lewis 2015). As for enlisting provincial governments, we heartily agree. A great deal can be accomplished by the Council of the Federation of Canadian Premiers. But, the entire basis for this philosophy and the reference paper itself assumes a top-down approach to policy and practice. That is what we are trying to change in Alberta and we next discuss. Bottom-up clinically led change, driven by measurement and evidence, has to meet with the top-down approach being presented and widely practiced. While true for each category of financing, stewardship and resource generation, in no place is this truer than what is described and included in "health system stewardship." This commentary draws from Verma and Bhatia (2016) and demonstrates how Alberta, through the use of Strategic Clinical Networks (SCNs), is responding to the Triple Aim. We offer three examples of provincially scaled innovations, each representing one or more arms of the Triple Aim.

  2. Combinatorics of RNA Secondary Structures with Base Triples.

    Science.gov (United States)

    Müller, Robert; Nebel, Markus E

    2015-07-01

    The structure of RNA has been the subject of intense research over the last decades due to its importance for the correct functioning of RNA molecules in biological processes. Hence, a large number of models for RNA folding and corresponding algorithms for structure prediction have been developed. However, previous models often only consider base pairs, although every base is capable of up to three edge-to-edge interactions with other bases. Recently, Höner zu Siederdissen et al. presented an extended model of RNA secondary structure, including base triples together with a folding algorithm-the first thermodynamics-based algorithm that allows the prediction of secondary structures with base triples. In this article, we investigate the search space processed by this new algorithm, that is, the combinatorics of extended RNA secondary structures with base triples. We present generalized definitions for structural motifs like hairpins, stems, bulges, or interior loops occurring in structures with base triples. Furthermore, we prove precise asymptotic results for the number of different structures (size of search space) and expectations for various parameters associated with structural motifs (typical shape of folding). Our analysis shows that the asymptotic number of secondary structures of size n increases exponentially to [Formula: see text] compared to the classic model by Stein and Waterman for which [Formula: see text] structures exist. A comparison with the classic model reveals large deviations in the expected structural appearance, too. The inclusion of base triples constitutes a significant refinement of the combinatorial model of RNA secondary structure, which, by our findings, is quantitatively characterized. Our results are of special theoretical interest, because a closer look at the numbers involved suggests that extended RNA secondary structures constitute a new combinatorial class not bijective with any other combinatorial objects studied so far.

  3. a simple a simple excitation control excitation control excitation

    African Journals Online (AJOL)

    eobe

    synchronous generator from no-load to full load while maintaining the rated terminal voltage on the stator terminals. The d-q rotor reference frame equations were used for the calculations and it is shown that values of the field voltages determined follow a simple quadratic relationship that offer a very simple control scheme, ...

  4. mTOR in breast cancer: differential expression in triple-negative and non-triple-negative tumors.

    LENUS (Irish Health Repository)

    Walsh, S

    2012-04-01

    Triple-negative breast cancer (TNBC) is defined by the absence of estrogen receptors (ER), progesterone receptors (PR) and overexpression of HER2. Targeted therapy is currently unavailable for this subgroup of breast cancer patients. mTOR controls cancer cell growth, survival and invasion and is thus a potential target for the treatment of patients with TNBC. Using immunohistochemistry, mTOR and p-mTOR were measured in 89 TNBCs and 99 non-TNBCs. While mTOR expression was confined to tumor cell cytoplasm, p-mTOR staining was located in the nucleus, perinuclear area and in the cytoplasm. Potentially important, was our finding that nuclear p-mTOR was found more frequently in triple-negative than non triple-negative cancers (p < 0.001). These results suggest that mTOR may play a more important role in the progression of TNBC compared to non-TNBC. Based on these findings, we conclude that mTOR may be a new target for the treatment of triple-negative breast cancer.

  5. Prevalence of Germline Mutations in Genes Engaged in DNA Damage Repair by Homologous Recombination in Patients with Triple-Negative and Hereditary Non-Triple-Negative Breast Cancers.

    Directory of Open Access Journals (Sweden)

    Pawel Domagala

    Full Text Available This study sought to assess the prevalence of common germline mutations in several genes engaged in the repair of DNA double-strand break by homologous recombination in patients with triple-negative breast cancers and hereditary non-triple-negative breast cancers. Tumors deficient in this type of DNA damage repair are known to be especially sensitive to DNA cross-linking agents (e.g., platinum drugs and to poly(ADP-ribose polymerase (PARP inhibitors.Genetic testing was performed for 36 common germline mutations in genes engaged in the repair of DNA by homologous recombination, i.e., BRCA1, BRCA2, CHEK2, NBN, ATM, PALB2, BARD1, and RAD51D, in 202 consecutive patients with triple-negative breast cancers and hereditary non-triple-negative breast cancers.Thirty five (22.2% of 158 patients in the triple-negative group carried mutations in genes involved in DNA repair by homologous recombination, while 10 (22.7% of the 44 patients in the hereditary non-triple-negative group carried such mutations. Mutations in BRCA1 were most frequent in patients with triple-negative breast cancer (18.4%, and mutations in CHEK2 were most frequent in patients with hereditary non-triple-negative breast cancers (15.9%. In addition, in the triple-negative group, mutations in CHEK2, NBN, and ATM (3.8% combined were found, while mutations in BRCA1, NBN, and PALB2 (6.8% combined were identified in the hereditary non-triple-negative group.Identifying mutations in genes engaged in DNA damage repair by homologous recombination other than BRCA1/2 can substantially increase the proportion of patients with triple-negative breast cancer and hereditary non-triple-negative breast cancer who may be eligible for therapy using PARP inhibitors and platinum drugs.

  6. Prevalence of Germline Mutations in Genes Engaged in DNA Damage Repair by Homologous Recombination in Patients with Triple-Negative and Hereditary Non-Triple-Negative Breast Cancers.

    Science.gov (United States)

    Domagala, Pawel; Jakubowska, Anna; Jaworska-Bieniek, Katarzyna; Kaczmarek, Katarzyna; Durda, Katarzyna; Kurlapska, Agnieszka; Cybulski, Cezary; Lubinski, Jan

    2015-01-01

    This study sought to assess the prevalence of common germline mutations in several genes engaged in the repair of DNA double-strand break by homologous recombination in patients with triple-negative breast cancers and hereditary non-triple-negative breast cancers. Tumors deficient in this type of DNA damage repair are known to be especially sensitive to DNA cross-linking agents (e.g., platinum drugs) and to poly(ADP-ribose) polymerase (PARP) inhibitors. Genetic testing was performed for 36 common germline mutations in genes engaged in the repair of DNA by homologous recombination, i.e., BRCA1, BRCA2, CHEK2, NBN, ATM, PALB2, BARD1, and RAD51D, in 202 consecutive patients with triple-negative breast cancers and hereditary non-triple-negative breast cancers. Thirty five (22.2%) of 158 patients in the triple-negative group carried mutations in genes involved in DNA repair by homologous recombination, while 10 (22.7%) of the 44 patients in the hereditary non-triple-negative group carried such mutations. Mutations in BRCA1 were most frequent in patients with triple-negative breast cancer (18.4%), and mutations in CHEK2 were most frequent in patients with hereditary non-triple-negative breast cancers (15.9%). In addition, in the triple-negative group, mutations in CHEK2, NBN, and ATM (3.8% combined) were found, while mutations in BRCA1, NBN, and PALB2 (6.8% combined) were identified in the hereditary non-triple-negative group. Identifying mutations in genes engaged in DNA damage repair by homologous recombination other than BRCA1/2 can substantially increase the proportion of patients with triple-negative breast cancer and hereditary non-triple-negative breast cancer who may be eligible for therapy using PARP inhibitors and platinum drugs.

  7. Descent principle in modular Galois theory

    Indian Academy of Sciences (India)

    Elsewhere this was proved under certain conditions by using the classification of finite simple groups, and under some other conditions by using Kantor's classification of linear groups containing a Singer cycle. Now under different conditions we prove it by using Cameron-Kantor's classification of two-transitive linear groups ...

  8. Proceedings – Mathematical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Elsewhere this was proved under certain conditions by using the classification of finite simple groups, and under some other conditions by using Kantor's classification of linear groups containing a Singer cycle. Now under different conditions we prove it by using Cameron-Kantor's classification of two-transitive linear groups ...

  9. Simple Rules for Detecting Depression

    NARCIS (Netherlands)

    Jenny, M.A.; Pachur, T.; Williams, S.L.; Becker, E.S.; Margraf, J.

    2013-01-01

    Depressive disorders are major public health issues worldwide. We tested the capacity of a simple lexicographic and noncompensatory fast and frugal tree (FFT) and a simple compensatory unit-weight model to detect depressed mood relative to a complex compensatory logistic regression and a naïve

  10. Liquid-Vapor Argon Isotope Fractionation from the Triple Point to the Critical Point

    DEFF Research Database (Denmark)

    Phillips, J. T.; Linderstrøm-Lang, C. U.; Bigeleisen, J.

    1972-01-01

    The statistical thermodynamic treatment of the equilibrium between a nonideal liquid mixture of isotopes and a vapor phase is extended to include isotope effects on the equation of state of the gas. The result is particularly simple when the isotopic partition functions in a given phase are compa......The statistical thermodynamic treatment of the equilibrium between a nonideal liquid mixture of isotopes and a vapor phase is extended to include isotope effects on the equation of state of the gas. The result is particularly simple when the isotopic partition functions in a given phase...... are compared at the same molar volume. The isotope fractionation factor α for 36Ar∕40Ar between liquid and vapor has been measured from the triple point to the critical temperature. The results are compared with previous vapor pressure data, which cover the range 84–102°K. Although the agreement is within....... The fractionation factor approaches zero at the critical temperature with a nonclassical critical index equal to 0.42±0.02.〈∇2Uc〉/ρc in liquid argon is derived from the experimental fractionation data and calculations of 〈∇2Ug〉/ρg for a number of potential functions for gaseous argon....

  11. An optimized clarithromycin-free 14-day triple therapy for Helicobacter pylori eradication achieves high cure rates in Uruguay.

    Science.gov (United States)

    Dacoll, Cristina; Sánchez-Delgado, Jordi; Balter, Henia; Pazos, Ximena; Di Pace, María; Sandoya, Gabriela; Cohen, Henry; Calvet, Xavier

    Strong acid inhibition increases cure rates with triple therapy and 14-day are more effective than 7-day treatments. The combination of amoxicillin plus metronidazole at full doses has been shown to overcome metronidazole resistance and to achieve good eradication rates even in patients harboring resistant strains. No previous studies have been reported in Latin-America with this optimized triple-therapy scheme. The aim of the present study was to assess the eradication rate and tolerance of a new first-line treatment regimen associating strong acid inhibition, amoxicillin and metronidazole. Patients from the Clínica de Gastroenterología of the Hospital de Clínicas (Montevideo, Uruguay) were included. Hp status was mainly assessed by at least one of the following: histologyor urea breath test (UBT). A 14-day treatment was prescribed comprising esomeprazole 40mg twice a day plus amoxicillin 1g and metronidazole 500mg, both three times a day. H. pylori cure was assessed by UBT. Forty-one patients were enrolled. Mean age was 53.3±13 years and 17.1% of patients were male. Main indications for treatment were: functional dyspepsia (27.5%), gastritis (45%), gastric or duodenal erosions (20%), gastric ulcer (5%) and intestinal metaplasia (2.5%). H. pylori eradication was achieved in 33 of the 37 patients who returned for follow-up. Eradication rates were 80.5% (95% CI: 68.4-92.6) by intention-to-treat (ITT) analysis and 89.2% (95% CI; 79.2-99.2) per protocol (PP). No major side effects were reported; 26 patients (65.8%) complained of mild side effects (nausea, diarrhea and headache). Cure rates of this triple therapy including esomeprazole, amoxicillin and metronidazole were 81% per ITT and the treatment was well tolerated. These optimal results with a simple clarithromycin-free triple therapy are better than described for standard triple therapy but there is still room for improvement to reach the desired target of 90% per ITT. Copyright © 2017 Elsevier España, S

  12. EXTREME AO OBSERVATIONS OF TWO TRIPLE ASTEROID SYSTEMS WITH SPHERE

    Energy Technology Data Exchange (ETDEWEB)

    Yang, B.; Wahhaj, Z.; Dumas, C.; Marsset, M. [European Southern Observatory, Santiago (Chile); Beauvalet, L. [National Observatory, Rio de Janeiro (Brazil); Marchis, F.; Nielsen, E. L. [Carl Sagan Center at the SETI Institute, Mountain View, CA (United States); Vachier, F., E-mail: byang@eso.org [Institut de Mécanique Céleste et de Calcul des Éphémérides, Paris (France)

    2016-04-01

    We present the discovery of a new satellite of asteroid (130) Elektra—S/2014 (130) 1—in differential imaging and in integral field spectroscopy data over multiple epochs obtained with Spectro-Polarimetric High-contrast Exoplanet Research/Very Large Telescope. This new (second) moonlet of Elektra is about 2 km across, on an eccentric orbit, and about 500 km away from the primary. For a comparative study, we also observed another triple asteroid system, (93) Minerva. For both systems, component-resolved reflectance spectra of the satellites and primary were obtained simultaneously. No significant spectral difference was observed between the satellites and the primary for either triple system. We find that the moonlets in both systems are more likely to have been created by sub-disruptive impacts as opposed to having been captured.

  13. Characteristic of a triple-cathode vacuum arc plasma source.

    Science.gov (United States)

    Xiang, W; Li, M; Chen, L

    2012-02-01

    In order to generate a better ion beam, a triple-cathode vacuum arc plasma source has been developed. Three plasma generators in the vacuum arc plasma source are equally located on a circle. Each generator initiated by means of a high-voltage breakdown between the cathode and the anode could be operated separately or simultaneously. The arc plasma expands from the cathode spot region in vacuum. In order to study the behaviors of expanding plasma plume generated in the vacuum arc plasma source, a Langmuir probe array is employed to measure the saturated ion current of the vacuum arc plasma source. The time-dependence profiles of the saturated current density of the triple vacuum arc plasma source operated separately and simultaneously are given. Furthermore, the plasma characteristic of this vacuum arc plasma source is also presented in the paper.

  14. Photo-active collagen systems with controlled triple helix architecture

    CERN Document Server

    Tronci, Giuseppe; Wood, David J

    2013-01-01

    The design of photo-active collagen systems is presented as a basis for establishing biomimetic materials with varied network architecture and programmable macroscopic properties. Following in-house isolation of type I collagen, reaction with vinyl-bearing compounds of varied backbone rigidity, i.e. 4-vinylbenzyl chloride (4VBC) and glycidyl methacrylate (GMA), was carried out. TNBS colorimetric assay, 1H-NMR and ATR-FTIR confirmed covalent and tunable functionalization of collagen lysines. Depending on the type and extent of functionalization, controlled stability and thermal denaturation of triple helices were observed via circular dichroism (CD), whereby the hydrogen-bonding capability of introduced moieties was shown to play a major role. Full gel formation was observed following photo-activation of functionalized collagen solutions. The presence of a covalent network only slightly affected collagen triple helix conformation (as observed by WAXS and ATR-FTIR), confirming the structural organization of fun...

  15. Triple and quartic gauge boson couplings at the LHC

    CERN Document Server

    Kupco, Alexander; The ATLAS collaboration

    2017-01-01

    This report at the conference Physics in Collision 2017 reviews recent results from the ATLAS and CMS experiments on production of gauge boson pairs, triples, and vector boson scattering (VBS) processes. Large datasets from LHC proton-proton collisions at $\\sqrt{s}=8$ and $13\\,\\mathrm{TeV}$ allowed the first observations of rare processes: triboson production in channel $Z\\gamma\\gamma$ at $\\sqrt{s}=8\\,\\mathrm{TeV}$ and VBS of same signed WW at $\\sqrt{s}=13\\,\\mathrm{TeV}$. Both experiments observe good agreement with the Standard model (SM) predictions. The data were used to set new limits on anomalous triple and quartic gauge couplings not present in the SM.

  16. Viscoplastic sculpting in stable triple layer heavy oil transport flow

    Science.gov (United States)

    Sarmadi, Parisa; Hormozi, Sarah; A. Frigaard, Ian

    2017-11-01

    In we introduced a novel methodology for efficient transport of heavy oil via a triple layer core-annular flow. Pumping pressures are significantly reduced by concentrating high shear rates to a lubricating layer, while ideas from Visco-Plastic Lubrication are used to eliminate interfacial instabilities. We purposefully position a shaped unyielded skin of a viscoplastic fluid between the transported oil and the lubricating fluid layer to balance the density difference between the fluids. Here we address the sculpting of the shaped skin within a concentric inflow manifold. We use the quasi-steady model to provide inputs to an axisymmetric triple layer computation, showing the development of the streamwise skin profile and establishment of the flow. For this, we use a finite element discretization with the augmented-Lagrangian method to represent the yield surface behaviour accurately and a PLIC method to track the interface motion.

  17. A triple risk model for unexplained late stillbirth.

    Science.gov (United States)

    Warland, Jane; Mitchell, Edwin A

    2014-04-14

    The triple risk model for sudden infant death syndrome (SIDS) has been useful in understanding its pathogenesis. Risk factors for late stillbirth are well established, especially relating to maternal and fetal wellbeing. We propose a similar triple risk model for unexplained late stillbirth. The model proposed by us results from the interplay of three groups of factors: (1) maternal factors (such as maternal age, obesity, smoking), (2) fetal and placental factors (such as intrauterine growth retardation, placental insufficiency), and (3) a stressor (such as venocaval compression from maternal supine sleep position, sleep disordered breathing). We argue that the risk factors within each group in themselves may be insufficient to cause the death, but when they interrelate may produce a lethal combination. Unexplained late stillbirth occurs when a fetus who is somehow vulnerable dies as a result of encountering a stressor and/or maternal condition in a combination which is lethal for them.

  18. Viscous solution of the triple shock reflection problem

    CERN Document Server

    Lau-Chapdelaine, S She-Ming

    2016-01-01

    The reflection of a triple-shock configuration was studied numerically in two dimensions using the Navier-Stokes equations. The flow field was initialized using three shock theory, and the reflection of the triple point on a plane of symmetry was studied. The conditions simulated a stoichiometric methane-oxygen detonation cell at low pressure on time scales preceding ignition, when the gas was assumed to be thermodynamically inert. Viscosity was found to play an important role on some shock reflection mechanisms believed to accelerate reaction rates in detonations where time scales are small. A small wall jet was present in the double Mach reflection and increased in size with Reynolds number, eventually forming a small vortex. Kelvin-Helmholtz instabilities were absent and there was no Mach stem bifurcation at Reynolds numbers corresponding to and exceeding the induction length. Kelvin-Helmholtz instabilities are unlikely to be a source of rapid reactions in detonations at time scales commensurate with the i...

  19. Triple dividends of water consumption charges in South Africa

    Science.gov (United States)

    Letsoalo, Anthony; Blignaut, James; de Wet, Theuns; de Wit, Martin; Hess, Sebastiaan; Tol, Richard S. J.; van Heerden, Jan

    2007-05-01

    The South African government is exploring ways to address water scarcity problems by introducing a water resource management charge on the quantity of water used in sectors such as irrigated agriculture, mining, and forestry. It is expected that a more efficient water allocation, lower use, and a positive impact on poverty can be achieved. This paper reports on the validity of these claims by applying a computable general equilibrium model to analyze the triple dividend of water consumption charges in South Africa: reduced water use, more rapid economic growth, and a more equal income distribution. It is shown that an appropriate budget-neutral combination of water charges, particularly on irrigated agriculture and coal mining, and reduced indirect taxes, particularly on food, would yield triple dividends, that is, less water use, more growth, and less poverty.

  20. Triple Helix Formation in a Topologically Controlled DNA Nanosystem.

    Science.gov (United States)

    Yamagata, Yutaro; Emura, Tomoko; Hidaka, Kumi; Sugiyama, Hiroshi; Endo, Masayuki

    2016-04-11

    In the present study, we demonstrate single-molecule imaging of triple helix formation in DNA nanostructures. The binding of the single-molecule third strand to double-stranded DNA in a DNA origami frame was examined using two different types of triplet base pairs. The target DNA strand and the third strand were incorporated into the DNA frame, and the binding of the third strand was controlled by the formation of Watson-Crick base pairing. Triple helix formation was monitored by observing the structural changes in the incorporated DNA strands. It was also examined using a photocaged third strand wherein the binding of the third strand was directly observed using high-speed atomic force microscopy during photoirradiation. We found that the binding of the third strand could be controlled by regulating duplex formation and the uncaging of the photocaged strands in the designed nanospace. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Mixed Hyperlipidemia Associated with Triple X Syndrome (A Case Report

    Directory of Open Access Journals (Sweden)

    Anton-Pǎduraru Dana-Teodora

    2014-06-01

    Full Text Available Lipid metabolism abnormalities in children may be hereditary or secondary to certain diseases (obesity, type 2 diabetes mellitus. Often elevated triglycerides values are associated with high cholesterol values, playing a major role on atherosclerosis. The triple X syndrome also called “the superfemale syndrome” is not a rare condition, but it is usually undiagnosed or occasionally diagnosed when other investigations are done. The authors present the case of a child admitted in the 3rd Clinic of Pediatrics -“Sf. Maria” Children’s Emergency Hospital, Iaşi -Romania for the continuation of her lipid metabolism investigations, being diagnosed on this occasion with the triple X syndrome. We conclude that the investigation of lipid metabolism, early identification of lipid abnormalities and proper treatment significantly reduce the prevalence of cardiovascular disease in adults. We cannot specify the impact of the presence of the chromosomal anomaly, as it is an accidental association

  2. S-matrix calculation of the triple-alpha reaction

    Science.gov (United States)

    Fushiki, Ikko; Lamb, D. Q.

    1987-01-01

    An S-matrix formalism is developed which can be applied to reactions in which electron screening is important, including three-body reactions and reactions involving weak interactions. The various regimes of the triple-alpha reactions are systematically discussed, and a new nonresonant regime at high densities is identified. Using the S-matrix formalism, an analytic expression is obtained for the screened triple-alpha reactions which is accurate for all temperatures and densities. The results are compared with those of Cameron (1959) and Nomoto et al. (1985), and the latter's expression for the unscreened reaction rate is verified. However, it is shown that the reaction rate in the pycnonuclear regime cannot be obtained from the unscreened rate using a screening factor, and that the results of Nomoto et al. therefore cannot be used in this regime.

  3. Grain boundary and triple junction diffusion in nanocrystalline copper

    Energy Technology Data Exchange (ETDEWEB)

    Wegner, M., E-mail: m.wegner@uni-muenster.de; Leuthold, J.; Peterlechner, M.; Divinski, S. V., E-mail: divin@uni-muenster.de [Institut für Materialphysik, Universität Münster, Wilhelm-Klemm-Straße 10, D-48149, Münster (Germany); Song, X., E-mail: xysong@bjut.edu.cn [College of Materials Science and Engineering, Beijing University of Technology, 100124 Beijing (China); Wilde, G. [Institut für Materialphysik, Universität Münster, Wilhelm-Klemm-Straße 10, D-48149, Münster (Germany); Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, 200444 Shanghai (China)

    2014-09-07

    Grain boundary and triple junction diffusion in nanocrystalline Cu samples with grain sizes, 〈d〉, of ∼35 and ∼44 nm produced by spark plasma sintering were investigated by the radiotracer method using the {sup 63}Ni isotope. The measured diffusivities, D{sub eff}, are comparable with those determined previously for Ni grain boundary diffusion in well-annealed, high purity, coarse grained, polycrystalline copper, substantiating the absence of a grain size effect on the kinetic properties of grain boundaries in a nanocrystalline material at grain sizes d ≥ 35 nm. Simultaneously, the analysis predicts that if triple junction diffusion of Ni in Cu is enhanced with respect to the corresponding grain boundary diffusion rate, it is still less than 500⋅D{sub gb} within the temperature interval from 420 K to 470 K.

  4. Triple A syndrome: two novel mutations in the AAAS gene.

    Science.gov (United States)

    Thümmler, Susanne; Huebner, Angela; Baechler-Sadoul, Elisabeth

    2009-01-01

    Triple A syndrome is a rare disease of autosomal recessive inheritance. It was first described in 1978. The typical triad includes adrenocorticotrophic-hormone-resistant glucocorticoid insufficiency, reduced or absent tearing (alacrima) and achalasia. But clinical symptoms can be extremely heterogeneous and of variable clinically expression. This report describes a 7-year-old boy with a 1 year history of fatigue and muscle weakness. Physical examination showed skin and mucosal hyperpigmentation, and hormonal analysis revealed isolated glucocorticoid function. Medical history was marked by megaoesophagus and achalasia. The absence of tears when crying had been noted since birth. In the presence of the classical triad, triple A syndrome was diagnosed. Clinical diagnosis was confirmed by molecular analysis of the AAAS gene on chromosome 12q13. The novel compound heterozygous mutation c.1304delA and c.1292-1294delTTCinsA was found.

  5. Photodissociation of methyl formate: Conical intersections, roaming and triple fragmentation

    Energy Technology Data Exchange (ETDEWEB)

    Lin, King-Chuen; Tsai, Po-Yu [Department of Chemistry, National Taiwan University, Taipei 106, Taiwan (China); Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 106, Taiwan (China); Chao, Meng-Hsuan [Department of Chemistry, National Taiwan University, Taipei 106, Taiwan (China); Kasai, Toshio [Department of Chemistry, National Taiwan University, Taipei 106, Taiwan (China); Graduate School of Science, Department of Chemistry, Osaka University, Toyonaka, 560-0043 Osaka (Japan); Lombardi, Andrea [Dipartimento di Chimica, Università di Perugia, 06123 Perugia (Italy); Palazzetti, Federico [Scuola Normale Superiore, 56126 Pisa (Italy); Aquilanti, Vincenzo [Dipartimento di Chimica, Università di Perugia, 06123 Perugia (Italy); Consiglio Nazionale delle Ricerche, Istituto di Struttura della Materia, 00016 Roma (Italy)

    2015-12-31

    The photodissociation channels of methyl formate have been extensively investigated by two different advanced experimental techniques, ion imaging and Fourier-Transform-Infrared emission spectroscopy, combined with quantum chemical calculations and molecular dynamics simulations. Our aim is to characterize the role of alternative routes to the conventional transition-state mediated pathway: the roaming and the triple fragmentation processes. The photolysis experiments, carried out at a range of laser wavelengths in the vicinity of the triple fragmentation threshold, beside the simulation of large bunches of classical trajectories with different initial conditions, have shown that both mechanisms share a common path that involves a conical intersection during the relaxation process from the electronic excited state S{sub 1} to the ground state S{sub 0}.

  6. Simple ocean carbon cycle models

    Energy Technology Data Exchange (ETDEWEB)

    Caldeira, K. [Lawrence Livermore National Lab., CA (United States); Hoffert, M.I. [New York Univ., NY (United States). Dept. of Earth System Sciences; Siegenthaler, U. [Bern Univ. (Switzerland). Inst. fuer Physik

    1994-02-01

    Simple ocean carbon cycle models can be used to calculate the rate at which the oceans are likely to absorb CO{sub 2} from the atmosphere. For problems involving steady-state ocean circulation, well calibrated ocean models produce results that are very similar to results obtained using general circulation models. Hence, simple ocean carbon cycle models may be appropriate for use in studies in which the time or expense of running large scale general circulation models would be prohibitive. Simple ocean models have the advantage of being based on a small number of explicit assumptions. The simplicity of these ocean models facilitates the understanding of model results.

  7. Targeted Therapies in Triple-Negative Breast Cancer

    OpenAIRE

    Marmé, Frederik; Schneeweiss, Andreas

    2015-01-01

    Triple-negative breast cancer (TNBC) is a heterogeneous disease comprised of several biologically distinct subtypes. However, treatment is currently mainly relying on chemotherapy as there are no targeted therapies specifically approved for TNBC. Despite initial responses to chemotherapy, resistance frequently and rapidly develops and metastatic TNBC has a poor prognosis. New targeted approaches are, therefore, urgently needed. Currently, bevacizumab, a monoclonal anti-vascular endothelial gr...

  8. Tidal breakup of triple stars in the Galactic Centre

    Science.gov (United States)

    Fragione, Giacomo; Gualandris, Alessia

    2018-01-01

    The last decade has seen the detection of fast moving stars in the Galactic halo, the so-called hypervelocity stars (HVSs). While the bulk of this population is likely the result of a close encounter between a stellar binary and the supermassive black hole (MBH) in the Galactic Centre (GC), other mechanims may contribute fast stars to the sample. Few observed HVSs show apparent ages which are shorter than the flight time from the GC, thereby making the binary disruption scenario unlikely. These stars may be the result of the breakup of a stellar triple in the GC which led to the ejection of a hypervelocity binary (HVB). If such binary evolves into a blue straggler star due to internal processes after ejection, a rejuvenation is possible that make the star appear younger once detected in the halo. A triple disruption may also be responsible for the presence of HVBs, of which one candidate has now been observed. We present a numerical study of triple disruptions by the MBH in the GC and find that the most likely outcomes are the production of single HVSs and single/binary stars bound to the MBH, while the production of HVBs has a probability ≲ 1% regardless of the initial parameters. Assuming a triple fraction of ≈10% results in an ejection rate of ≲ 1{ Gyr}^{-1}, insufficient to explain the sample of HVSs with lifetimes shorter than their flight time. We conclude that alternative mechanisms are responsible for the origin of such objects and HVBs in general.

  9. Trends of triple negative breast cancer research (2007?2015)

    OpenAIRE

    Wang, Yiran; Zhai, Xiao; Liu, Chuan; Wang,Ning; Wang, Yajie

    2016-01-01

    Abstract Background: Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype. However, there have been limited data to evaluate the trend of TNBC research. This study aims to investigate the trend of TNBC research and compare the contribution of research from different regions, organizations, and authors. Methods: TNBC-related publications from 2007 to 2015 were retrieved from the Web of Science database. Excel 2013 (Redmond, Washington, USA), GraphPad Prism 5 (GraphPad Pr...

  10. Lifestyle Triple P: a parenting intervention for childhood obesity.

    Science.gov (United States)

    Gerards, Sanne M P L; Dagnelie, Pieter C; Jansen, Maria W J; van der Goot, Lidy O H M; de Vries, Nanne K; Sanders, Matthew R; Kremers, Stef P J

    2012-04-03

    Reversing the obesity epidemic requires the development and evaluation of childhood obesity intervention programs. Lifestyle Triple P is a parent-focused group program that addresses three topics: nutrition, physical activity, and positive parenting. Australian research has established the efficacy of Lifestyle Triple P, which aims to prevent excessive weight gain in overweight and obese children. The aim of the current randomized controlled trial is to assess the effectiveness of the Lifestyle Triple P intervention when applied to Dutch parents of overweight and obese children aged 4-8 years. This effectiveness study is called GO4fit. Parents of overweight and obese children are being randomized to either the intervention or the control group. Those assigned to the intervention condition receive the 14-week Lifestyle Triple P intervention, in which they learn a range of nutritional, physical activity and positive parenting strategies. Parents in the control group receive two brochures, web-based tailored advice, and suggestions for exercises to increase active playing at home. Measurements are taken at baseline, directly after the intervention, and at one year follow-up. Primary outcome measure is the children's body composition, operationalized as BMI z-score, waist circumference, and fat mass (biceps and triceps skinfolds). Secondary outcome measures are children's dietary behavior and physical activity level, parenting practices, parental feeding style, parenting style, parental self-efficacy, and body composition of family members (parents and siblings). Our intervention is characterized by a focus on changing general parenting styles, in addition to focusing on changing specific parenting practices, as obesity interventions typically do. Strengths of the current study are the randomized design, the long-term follow-up, and the broad range of both self-reported and objectively measured outcomes. Current Controlled Trials NTR 2555 MEC AZM/UM: NL 31988

  11. Lifestyle Triple P: a parenting intervention for childhood obesity

    Science.gov (United States)

    2012-01-01

    Background Reversing the obesity epidemic requires the development and evaluation of childhood obesity intervention programs. Lifestyle Triple P is a parent-focused group program that addresses three topics: nutrition, physical activity, and positive parenting. Australian research has established the efficacy of Lifestyle Triple P, which aims to prevent excessive weight gain in overweight and obese children. The aim of the current randomized controlled trial is to assess the effectiveness of the Lifestyle Triple P intervention when applied to Dutch parents of overweight and obese children aged 4–8 years. This effectiveness study is called GO4fit. Methods/Design Parents of overweight and obese children are being randomized to either the intervention or the control group. Those assigned to the intervention condition receive the 14-week Lifestyle Triple P intervention, in which they learn a range of nutritional, physical activity and positive parenting strategies. Parents in the control group receive two brochures, web-based tailored advice, and suggestions for exercises to increase active playing at home. Measurements are taken at baseline, directly after the intervention, and at one year follow-up. Primary outcome measure is the children’s body composition, operationalized as BMI z-score, waist circumference, and fat mass (biceps and triceps skinfolds). Secondary outcome measures are children’s dietary behavior and physical activity level, parenting practices, parental feeding style, parenting style, parental self-efficacy, and body composition of family members (parents and siblings). Discussion Our intervention is characterized by a focus on changing general parenting styles, in addition to focusing on changing specific parenting practices, as obesity interventions typically do. Strengths of the current study are the randomized design, the long-term follow-up, and the broad range of both self-reported and objectively measured outcomes. Trial Registration

  12. Triple Track: A New Paradigm for Developing Air Force Officers

    Science.gov (United States)

    2017-03-06

    AIR WAR COLLEGE AIR UNIVERSITY TRIPLE TRACK: A NEW PARADIGM FOR DEVELOPING AIR FORCE OFFICERS by Tracy N. Hunter, Lieutenant...their careers in order to possess the skills to effectively integrate capabilities across the joint force.5 The AF needs to alter the paradigm on...same time developing officers who can integrating elements across multiple domains. This new paradigm will encourage a focus on officer

  13. Neutron Star Formation and Evolution - Singles, Binaries and Triples

    Science.gov (United States)

    Tauris, Thomas

    I will review recent progress, and highlight unsolved puzzles, related to the formation and evolution of neutron stars. Examples include birth events of neutron stars (electron capture vs iron core-collapse SNe and AIC), torque decay of isolated pulsars, recycling of millisecond pulsars and the nature of their companions. Finally, I will discuss the triple pulsar and the new emerging class of millisecond pulsars in highly eccentric orbits.

  14. Lifestyle Triple P: a parenting intervention for childhood obesity

    Directory of Open Access Journals (Sweden)

    Gerards Sanne MPL

    2012-04-01

    Full Text Available Abstract Background Reversing the obesity epidemic requires the development and evaluation of childhood obesity intervention programs. Lifestyle Triple P is a parent-focused group program that addresses three topics: nutrition, physical activity, and positive parenting. Australian research has established the efficacy of Lifestyle Triple P, which aims to prevent excessive weight gain in overweight and obese children. The aim of the current randomized controlled trial is to assess the effectiveness of the Lifestyle Triple P intervention when applied to Dutch parents of overweight and obese children aged 4–8 years. This effectiveness study is called GO4fit. Methods/Design Parents of overweight and obese children are being randomized to either the intervention or the control group. Those assigned to the intervention condition receive the 14-week Lifestyle Triple P intervention, in which they learn a range of nutritional, physical activity and positive parenting strategies. Parents in the control group receive two brochures, web-based tailored advice, and suggestions for exercises to increase active playing at home. Measurements are taken at baseline, directly after the intervention, and at one year follow-up. Primary outcome measure is the children’s body composition, operationalized as BMI z-score, waist circumference, and fat mass (biceps and triceps skinfolds. Secondary outcome measures are children’s dietary behavior and physical activity level, parenting practices, parental feeding style, parenting style, parental self-efficacy, and body composition of family members (parents and siblings. Discussion Our intervention is characterized by a focus on changing general parenting styles, in addition to focusing on changing specific parenting practices, as obesity interventions typically do. Strengths of the current study are the randomized design, the long-term follow-up, and the broad range of both self-reported and objectively measured

  15. Trilayered Morphology of an ABC Triple Crystalline Triblock Terpolymer

    KAUST Repository

    Palacios, Jordana K.

    2017-09-07

    Triple crystalline triblock terpolymers are materials with remarkable semicrystalline superstructures. In this work, we report for first time the alternating triple lamellar morphology that self-assembles inside spherulites of a triblock terpolymer composed of poly(ethylene oxide) (PEO), poly(ε-caprolactone) (PCL), and poly(l-lactide) (PLLA). The morphology of the PEO-b-PCL-b-PLLA triblock terpolymer is compared to an analogous PCL-b-PLLA diblock copolymer. Both diblock and triblock form a single phase in the melt. Two crystallization protocols were employed to create particular crystalline morphologies. In both cases, the isothermal crystallization of the PLA block is induced first (at 81 °C, a temperature above the melting points of both PCL and PEO blocks) and PLLA spherulites form a template, whereupon cooling the other two blocks can crystallize within the PLLA interlamellar spaces. WAXS analysis demonstrated the double crystalline and triple crystalline nature of the materials. The lamellar structure was evaluated by AFM observations and SAXS measurements. Moreover, theoretical SAXS curves of one-dimensional structural models were calculated. AFM micrographs of the triblock terpolymer evidenced the three different lamellae of PLLA, PCL and PEO that coexist together within the same spherulite. Three different lamellar thickness were determined, and their dimensions suggested that all blocks crystallized in chain-folded conformations. The evolution of the triple lamellar morphology during heating of tricrystalline samples was followed by in situ synchrotron SAXS measurements. The theoretical analysis of the SAXS curves of the triblock terpolymer allowed us to propose a stacking morphological model, in which a particular trilayer structure exists, where one lamella of PCL or one lamella of PEO is inserted randomly between two adjacent PLLA lamellae.

  16. Biophysical studies of matrix metalloproteinase/triple-helix complexes.

    Science.gov (United States)

    Fields, Gregg B

    2014-01-01

    Several members of the zinc-dependent matrix metalloproteinase (MMP) family catalyze collagen degradation. The structures of MMPs, in solution and solid state and in the presence and absence of triple-helical collagen models, have been assessed by NMR spectroscopy, small-angle X-ray scattering, and X-ray crystallography. Structures observed in solution exhibit flexibility between the MMP catalytic (CAT) and hemopexin-like (HPX) domains, while solid-state structures are relatively compact. Evaluation of the maximum occurrence (MO) of MMP-1 conformations in solution found that, for all the high MO conformations, the CAT and HPX domains are not in tight contact, and the residues of the HPX domain reported to be responsible for the binding to the collagen triple-helix are solvent exposed. A mechanism for collagenolysis has been developed based on analysis of MMP solution structures. Information obtained from solid-state structures has proven valuable for analyzing specific contacts between MMPs and the collagen triple-helix. © 2014 Elsevier Inc. All rights reserved.

  17. Prenatal diagnosis and prognosis of triple X syndrome: 47, XXX.

    Science.gov (United States)

    Ben Hamouda, H; Mkacher, N; Elghezal, H; Bannour, H; Kamoun, M; Soua, H; Saad, A; Souissi, M M; Sfar, M T

    2009-11-01

    Triple X syndrome is a relatively common sex chromosomal abnormality occurring in 0,1% of live-born female infants. Most of these infants have a normal phenotype and only a few cases with 47, XXX karyotype have congenital malformations. We report three cases of triple X syndrome that were diagnosed prenatally by genetic amniocentesis for advanced maternal age and have been observed from birth to age of 3 to 12 years. A description of their growth and development is presented. The birth weight was normal in all patients and one of them had facial dysmorphism with right microphtalmia and auricular septal defect. During the first 2 years of life, the neuromotor development of these infants was not distinguishable from chromosomally normal children. By 3 years of age, two patients have a moderate developmental delay in speech and language. One girl 12-year-old had normal schooling. The diagnosis of the triple X syndrome can be never made because clinical demonstrations are not rather important to arouse the demand of a karyotype. Prenatal diagnosis is often made in front of the advanced maternal age. Expectant parents must be counseled as to the significance of this 47, XXX karyotype and prognostic information must be given.

  18. High-rate particle triggering with triple-GEM detector

    CERN Document Server

    Alfonsi, M; De Simone, P; Murtas, F; Poli-Lener, M; Bonivento, W; Cardini, A; Deplano, C; Raspino, D; Pinci, D

    2004-01-01

    We report the results of a systematic study of the time performance of triple-GEM detectors operated with Ar/CO//2/CF//4 and Ar/CF//4 /iso-C//4H//1//0 gas mixtures. This study and the detector development has been performed in the framework of an R&D activity on detectors for the innermost part (region R1) of the first muon station (M1) of the LHCb experiment. The use of fast gas mixtures allows to achieve a time resolution better than 5 ns (r.m.s.) and a single detector efficiency up to similar to 99% in a 20 ns time window. Discharge studies have been performed at the piM1 hadron beam facility of the Paul Scherrer Institute. Local aging properties were investigated exposing the detector to a collimated 5.9 keV X-rays beam. The whole R&D activity with different gas mixtures has been performed with small 10 multiplied by 10 cm**2 triple-GEM detector prototypes. A full size prototype (module-0) constituted by two 20 multiplied by 24 cm**2 triple-GEM detectors, equipped with front-end electronics based ...

  19. Photo-active collagen systems with controlled triple helix architecture

    Science.gov (United States)

    Tronci, Giuseppe; Russell, Stephen J.; Wood, David J.

    2016-01-01

    The design of photo-active collagen systems is presented as a basis for establishing biomimetic materials with varied network architecture and programmable macroscopic properties. Following in-house isolation of type I collagen, reaction with vinyl-bearing compounds of varied backbone rigidity, i.e. 4-vinylbenzyl chloride (4VBC) and glycidyl methacrylate (GMA), was carried out. TNBS colorimetric assay, 1H-NMR and ATR-FTIR confirmed covalent and tunable functionalization of collagen lysines. Depending on the type and extent of functionalization, controlled stability and thermal denaturation of triple helices were observed via circular dichroism (CD), whereby the hydrogen-bonding capability of introduced moieties was shown to play a major role. Full gel formation was observed following photo-activation of functionalized collagen solutions. The presence of a covalent network only slightly affected collagen triple helix conformation (as observed by WAXS and ATR-FTIR), confirming the structural organization of functionalized collagen precursors. Photo-activated hydrogels demonstrated an increased denaturation temperature (DSC) with respect to native collagen, suggesting that the formation of the covalent network successfully stabilized collagen triple helices. Moreover, biocompatibility and mechanical competence of obtained hydrogels were successfully demonstrated under physiologically-relevant conditions. These results demonstrate that this novel synthetic approach enabled the formation of biocompatible collagen systems with defined network architecture and programmable macroscopic properties, which can only partially be obtained with current synthetic methods. PMID:27398214

  20. Testbeam results for full-size triple GEM detectors

    CERN Document Server

    Sharma, Ram Krishna

    2015-01-01

    The High Luminosity LHC (HL-LHC) will provide exceptional instantaneous and integrated luminosities. The forward region $\\mid \\eta \\mid \\ge 1.5$ of the Compact Muon Solenoid (CMS) detector will face extremely high particle rates in tens of $KHz/cm^2$ and hence it will affect the momentum resolution and longevity of the muon detectors. To overcome these issues the CMS-GEM collaboration has proposed to install new large size rate capable Triple Gas Electron Multiplier (GEM) detectors in the forward region of CMS muon system. The first set of Triple GEM detectors will be installed in the GE1/1 region $(1.5 \\le \\eta \\le 2.2)$ of muon endcap during the long shutdown 2 of the LHC. Towards this goal, full size CMS Triple GEM prototype chambers have been fabricated and put under the test beam at the CERN SPS test beam facility. The GEM detectors were operated with two gas mixtures $Ar/CO_2$ (70/30) and $Ar/CO_2/CF_4$ (40/15/45). In 2014, good quality data was collected during test beam campaigns. In this paper, th...

  1. Chermak-Delgado Simple Groups

    OpenAIRE

    McCulloch, Ryan

    2015-01-01

    This paper provides the first steps in classifying the finite solvable groups having Property A, which is a property involving abelian normal subgroups. We see that this classification is reduced to classifying the solvable Chermak-Delgado simple groups, which the author defines. The author completes a classification of Chermak-Delgado simple groups under certain restrictions on the primes involved in the group order.

  2. Simple machines made simple a teacher resource manual

    CERN Document Server

    Andre, Ralph E St

    1993-01-01

    This book allows you to present scientific principles and simple mechanics through hands-on cooperative learning activities. Using inexpensive materials (e.g., tape, paper clips), students build simple machines-such as levers, pulleys, spring scales, gears, wheels and axles, windmills, and wedges-that demonstrate how things work. Activities have easy-to-locate materials lists, time requirements, and step-by-step directions (usually illustrated) on presentation. Ideas for bulletin boards, learning centers, and computer-assisted instruction are an added bonus.

  3. Construction of simple pathways and simple cycles in ecosystems.

    Science.gov (United States)

    Kincaid, D T; Pilette, R

    1992-06-01

    We present software tools for overcoming the problem of combinatorics in the enumeration of simple pathways and simple cycles in a first flow-through analysis of carbon transfer in large ecosystems. Rather than search through the very large number of potential routes in a reasonably sized ecosystem for the relatively small number of actual routes, our main algorithm performs an efficient rule-based construction of the actual routes. The enumeration of the unique pathways becomes tractable in terms of CPU time, which increases linearly with ecosystem size and connectedness. Networks of up to 80 entities can be evaluated using our software.

  4. Simple arithmetic: not so simple for highly math anxious individuals.

    Science.gov (United States)

    Chang, Hyesang; Sprute, Lisa; Maloney, Erin A; Beilock, Sian L; Berman, Marc G

    2017-12-01

    Fluency with simple arithmetic, typically achieved in early elementary school, is thought to be one of the building blocks of mathematical competence. Behavioral studies with adults indicate that math anxiety (feelings of tension or apprehension about math) is associated with poor performance on cognitively demanding math problems. However, it remains unclear whether there are fundamental differences in how high and low math anxious individuals approach overlearned simple arithmetic problems that are less reliant on cognitive control. The current study used functional magnetic resonance imaging to examine the neural correlates of simple arithmetic performance across high and low math anxious individuals. We implemented a partial least squares analysis, a data-driven, multivariate analysis method to measure distributed patterns of whole-brain activity associated with performance. Despite overall high simple arithmetic performance across high and low math anxious individuals, performance was differentially dependent on the fronto-parietal attentional network as a function of math anxiety. Specifically, low-compared to high-math anxious individuals perform better when they activate this network less-a potential indication of more automatic problem-solving. These findings suggest that low and high math anxious individuals approach even the most fundamental math problems differently. © The Author (2017). Published by Oxford University Press.

  5. Practical Session: Simple Linear Regression

    Science.gov (United States)

    Clausel, M.; Grégoire, G.

    2014-12-01

    Two exercises are proposed to illustrate the simple linear regression. The first one is based on the famous Galton's data set on heredity. We use the lm R command and get coefficients estimates, standard error of the error, R2, residuals …In the second example, devoted to data related to the vapor tension of mercury, we fit a simple linear regression, predict values, and anticipate on multiple linear regression. This pratical session is an excerpt from practical exercises proposed by A. Dalalyan at EPNC (see Exercises 1 and 2 of http://certis.enpc.fr/~dalalyan/Download/TP_ENPC_4.pdf).

  6. Synchronous triple-optical-path digital speckle pattern interferometry with fast discrete curvelet transform for measuring three-dimensional displacements

    Science.gov (United States)

    Gu, Guoqing; Wang, Kaifu; Wang, Yanfang; She, Bin

    2016-06-01

    Digital speckle pattern interferometry (DSPI) is a well-established and widely used optical measurement technique for obtaining qualitative as well as quantitative measurements of objects deformation. The simultaneous measurement of an object's surface displacements in three dimensions using DSPI is of great interest. This paper presents a triple-optical-path DSPI based method for the simultaneous and independent measurement of three-dimensional (3D) displacement fields. In the proposed method, in-plane speckle interferometers with dual-observation geometry and an out-of-plane interferometer are optimally combined to construct an integrated triple-optical-path DSPI system employing the phase shift technique, which uses only a single laser source and three cameras. These cameras are placed along a single line to synchronously capture real-time visible speckle fringe patterns in three dimensions. In addition, a pre-filtering method based on the fast discrete curvelet transform (FDCT) is utilized for denoising the obtained wrapped phase patterns to improve measurement accuracy. Finally, the simultaneous measurement of the 3D displacement fields of a simple beam and a composite laminated plate respectively subjected to three-point and single-point bend loading are investigated to validate the feasibility and effectiveness of the proposed method.

  7. Triple vacuum glazing: Heat transfer and basic mechanical design constraints

    Energy Technology Data Exchange (ETDEWEB)

    Manz, H.; Brunner, S.; Wullschleger, L. [Swiss Federal Laboratories for Materials Testing and Research (EMPA), Laboratory for Applied Physics in Building, Ueberlandstrasse 129, CH-8600 Duebendorf (Switzerland)

    2006-12-15

    Given the major role played by windows with regard to energy losses from buildings in cold climates, low thermal transmittance is an indispensable property of glazing in low-energy buildings. Evacuation offers the only means of achieving negligible gaseous conduction in glazing cavities. Application of low-emittance coatings to glass sheet surfaces inside the cavity reduces the radiative heat transfer. The feasibility of double vacuum glazing using arrays of support pillars between the glass sheets has been shown by other authors. This type of glazing is commercially manufactured today. Based on these achievements, our study set out to investigate heat transfer in triple vacuum glazing by means of (i) an analytical thermal network model and (ii) a numerical finite difference model. The study focused on the impact of the following parameters on thermal transmittance: emittances of glass sheet surfaces inside the cavity, support pillar radius, support pillar separation and thermal conductivity of support pillar material. The design procedure for triple vacuum glazing taking into account not only thermal but also mechanical stresses due to atmospheric pressure, i.e., to enable identification of favourable parameter sets, is presented. Our findings suggest that use of the triple vacuum glazing concept can significantly reduce the thermal transmittances achieved by the best insulation glazing units currently on the market. E.g., a centre-of-glazing thermal transmittance of less than 0.2Wm{sup -2}K{sup -1} is achievable using stainless steel support pillars, 6mm/4mm/6mm sheets of untempered soda-lime glass and four low-emittance coatings ({epsilon}=0.03). (author)

  8. Functional outcome after arthroscopic repair of triple shoulder instability

    Directory of Open Access Journals (Sweden)

    Glaydson Gomes Godinho

    Full Text Available ABSTRACT OBJECTIVE: To evaluate the functional outcomes of patients submitted to arthroscopic repair of triple labral lesion. METHODS: This was an analytical retrospective study of patients who underwent arthroscopic treatment of triple labral lesion from March 2005 to December 2014. Patients with at least one year of postoperative follow-up were included. A total of nine patients were evaluated. The mean age was 32.3 years and the dominant side was affected in five patients. Patients were functionally assessed regarding the range of motion (ROM in elevation, external rotation with the arm close to the body the arm in abduction of 90°, and internal rotation, and by the Carter-Rowe score. The degree of satisfaction was assessed at the end of the follow-up period. RESULTS: Three patients had less than five episodes of instability, four patients had between five and ten episodes, and two patients had more than ten episodes. Seven patients had positive O'Brien test for SLAP lesions and positive apprehension test in abduction and external rotation, and only one patient had apprehension in adduction and internal rotation. Three patients persisted with positive O'Brien test and one with apprehension in abduction and external rotation at the end of follow-up. The range of motion was complete in all cases. The median Carter-Rowe score increased from 40 preoperatively to 90 (p = 0.008. CONCLUSION: The arthroscopic repair of triple labral lesions allows for the restoration of the stability of the glenohumeral joint, achieving excellent functional results.

  9. Pembrolizumab and Ruxolitinib Phosphate in Treating Patients With Metastatic Stage IV Triple Negative Breast Cancer

    Science.gov (United States)

    2017-08-28

    Breast Carcinoma Metastatic in the Bone; Estrogen Receptor Negative; HER2/Neu Negative; Progesterone Receptor Negative; Recurrent Breast Carcinoma; Stage IV Breast Cancer; Triple-Negative Breast Carcinoma

  10. Triple-Divided Concha Bullosa: A New Anatomic Variation

    Directory of Open Access Journals (Sweden)

    Turhan San

    2013-01-01

    Full Text Available In recent years, with the widespread use of imaging techniques such as paranasal sinus computed tomography (CT, many variations of nasal turbinates have been described. One of these variations known as concha bullosa (CB is pneumatization of nasal turbinates. CB is the most frequently encountered anatomical variations of the middle turbinate. The term of septated concha bullosa has been described recently and it is an uncommon pneumatization anomaly of the middle turbinate. There has not been any study that correlates the number of septations and the presence of sinonasal pathologies. We hereby present a case of triple septated concha bullosa that has not been reported so far.

  11. Triple Negative Breast Cancer Team Project — EDRN Public Portal

    Science.gov (United States)

    Triple negative breast cancers (TNBC), comprise 15-20% of breast cancers, and are associated with later stage at diagnosis, increased mortality, and occur more frequently in younger women where mammographic screening is less reliable. TNBCs are more likely to be diagnosed by physical exam than by mammographic screening. There is an unmet clinical need for biomarkers for the early detection of TNBC. Here, we are proposing the development of a plasma-based biomarker panel for the routine screening of women over the age of 40 for TNBC that can be used to identify women for further imaging.

  12. Synthesis and crystal structure analysis of uranyl triple acetates

    Energy Technology Data Exchange (ETDEWEB)

    Klepov, Vladislav V., E-mail: vladislavklepov@gmail.com [Institute for Energy and Climate Research (IEK-6), Forschungszentrum Jülich GmbH, 52428 Jülich (Germany); Department of Chemistry, Samara National Research University, 443086 Samara (Russian Federation); Serezhkina, Larisa B.; Serezhkin, Victor N. [Department of Chemistry, Samara National Research University, 443086 Samara (Russian Federation); Alekseev, Evgeny V., E-mail: e.alekseev@fz-juelich.de [Institute for Energy and Climate Research (IEK-6), Forschungszentrum Jülich GmbH, 52428 Jülich (Germany); Institut für Kristallographie, RWTH Aachen University, 52066 Aachen (Germany)

    2016-12-15

    Single crystals of triple acetates NaR[UO{sub 2}(CH{sub 3}COO){sub 3}]{sub 3}·6H{sub 2}O (R=Mg, Co, Ni, Zn), well-known for their use as reagents for sodium determination, were grown from aqueous solutions and their structural and spectroscopic properties were studied. Crystal structures of the mentioned phases are based upon (Na[UO{sub 2}(CH{sub 3}COO){sub 3}]{sub 3}){sup 2–} clusters and [R(H{sub 2}O){sub 6}]{sup 2+} aqua-complexes. The cooling of a single crystal of NaMg[UO{sub 2}(CH{sub 3}COO){sub 3}]{sub 3}·6H{sub 2}O from 300 to 100 K leads to a phase transition from trigonal to monoclinic crystal system. Intermolecular interactions between the structural units and their mutual packing were studied and compared from the point of view of the stereoatomic model of crystal structures based on Voronoi-Dirichlet tessellation. Using this method we compared the crystal structures of the triple acetates with Na[UO{sub 2}(CH{sub 3}COO){sub 3}] and [R(H{sub 2}O){sub 6}][UO{sub 2}(CH{sub 3}COO){sub 3}]{sub 2} and proposed reasons of triple acetates stability. Infrared and Raman spectra were collected and their bands were assigned. - Graphical abstract: Single crystals of uranium based triple acetates, analytical reagents for sodium determination, were synthesized and structurally, spectroscopically and topologically characterized. The structures were compared with the structures of compounds from preceding families [M(H{sub 2}O){sub 6})][UO{sub 2}(CH{sub 3}COO){sub 3}]{sub 2} (M = Mg, Co, Ni, Zn) and Na[UO{sub 2}(CH{sub 3}COO){sub 3}]. Analysis was performed with the method of molecular Voronoi-Dirichlet polyhedra to reveal a large contribution of the hydrogen bonds into intermolecular interactions which can be a reason of low solubility of studied complexes.

  13. Management Options in Triple-Negative Breast Cancer

    Science.gov (United States)

    Minami, Christina A.; Chung, Debra U.; Chang, Helena R.

    2011-01-01

    Notorious for its poor prognosis and aggressive nature, triple-negative breast cancer (TNBC) is a heterogeneous disease entity. The nature of its biological specificity, which is similar to basal-like cancers, tumors arising in BRCA1 mutation carriers, and claudin-low cancers, is currently being explored in hopes of finding the targets for novel biologics and chemotherapeutic agents. In this review, we aim to give a broad overview of the disease’s nomenclature and epidemiology, as well as the basic mechanisms of emerging targeted therapies and their performance in clinical trials to date. PMID:21863131

  14. Novel measurements of anomalous triple gauge couplings for the LHC

    Science.gov (United States)

    Azatov, A.; Elias-Miró, J.; Reyimuaji, Y.; Venturini, E.

    2017-10-01

    Finding better ways to prove the Standard Model Effective Field Theory is a very important direction of research. This paper focuses on measurements of Electroweak triple gauge couplings, paying special attention on the regime of validity of the Effective Field Theory (EFT). In this regard, one of our goals is to find measurements leading to a large increase of the interference between the SM amplitude and the contribution of irrelevant operators in the EFT. We propose two such distributions that will lead to a better accuracy. Improvements compared to the traditional methods as well as LHC high luminosity prospects are discussed.

  15. Prevention of tooth discoloration associated with triple antibiotics

    Directory of Open Access Journals (Sweden)

    Bona Kim

    2013-05-01

    Full Text Available Regenerative endodontics has a potential to heal a partially necrotic pulp, which can be beneficial for the continued root development and strengthening of immature teeth. For this purpose, triple antibiotic mixture of ciprofloxacin, metronidazole, and minocycline was recommended as intracanal medicament in an attempt to disinfect the root canal system for revascularization of a tooth with a necrotic pulp. However, discoloration of the tooth was reported after applying this. This case shows the idea for preventing the tooth discoloration using a delivery syringe (SW-O-01, Shinwoo dental to avoid the contact between the clinical crown and the antibiotics.

  16. Simple Combinatorial Optimisation Cost Games

    NARCIS (Netherlands)

    van Velzen, S.

    2005-01-01

    In this paper we introduce the class of simple combinatorial optimisation cost games, which are games associated to {0, 1}-matrices.A coalitional value of a combinatorial optimisation game is determined by solving an integer program associated with this matrix and the characteristic vector of the

  17. A Simple Plant Growth Analysis.

    Science.gov (United States)

    Oxlade, E.

    1985-01-01

    Describes the analysis of dandelion peduncle growth based on peduncle length, epidermal cell dimensions, and fresh/dry mass. Methods are simple and require no special apparatus or materials. Suggests that limited practical work in this area may contribute to students' lack of knowledge on plant growth. (Author/DH)

  18. Simple stålrammebygninger

    DEFF Research Database (Denmark)

    Ellum, J.C.

    Anvisningen gennemgår dimensioneringen og bringer detaljerede konstruktionstegninger til simple stålrammebygninger, dvs. lukkede, fritliggende bygninger i én etage, hvor tagkonstruktionen ud over egenlast kun er påvirket af naturlaster, dvs. sne og vind. Dimensioneringen sker ved at udfylde et...

  19. Determining Salinity by Simple Means.

    Science.gov (United States)

    Schlenker, Richard M.

    This paper describes the construction and use of a simple salinometer. The salinometer is composed, mainly, of a milliammeter and a battery and uses the measurement of current flow to determine the salinity of water. A complete list of materials is given, as are details of construction and operation of the equipment. The use of the salinometer in…

  20. Simple stålrammebygninger

    DEFF Research Database (Denmark)

    Ellum, J.C.

    Anvisningen gennemgår dimensioneringen og bringer detaljerede konstruktionstegninger til simple stålrammebygninger, dvs. lukkede, fritliggende bygninger i én etage, hvor tagkonstruktionen ud over egenlast kun er påvirket af naturlaster, dvs. sne og vind. Dimensioneringen sker ved at udfylde et di...

  1. Simple models with ALICE fluxes

    CERN Document Server

    Striet, J

    2000-01-01

    We introduce two simple models which feature an Alice electrodynamics phase. In a well defined sense the Alice flux solutions we obtain in these models obey first order equations similar to those of the Nielsen-Olesen fluxtube in the abelian higgs model in the Bogomol'nyi limit. Some numerical solutions are presented as well.

  2. Solving Simple Kinetics without Integrals

    Science.gov (United States)

    de la Pen~a, Lisandro Herna´ndez

    2016-01-01

    The solution of simple kinetic equations is analyzed without referencing any topic from differential equations or integral calculus. Guided by the physical meaning of the rate equation, a systematic procedure is used to generate an approximate solution that converges uniformly to the exact solution in the case of zero, first, and second order…

  3. Simple Indolizidine and Quinolizidine Alkaloids.

    Science.gov (United States)

    Michael, Joseph P

    2016-01-01

    This review of simple indolizidine and quinolizidine alkaloids (i.e., those in which the parent bicyclic systems are in general not embedded in polycyclic arrays) is an update of the previous coverage in Volume 55 of this series (2001). The present survey covers the literature from mid-1999 to the end of 2013; and in addition to aspects of the isolation, characterization, and biological activity of the alkaloids, much emphasis is placed on their total synthesis. A brief introduction to the topic is followed by an overview of relevant alkaloids from fungal and microbial sources, among them slaframine, cyclizidine, Steptomyces metabolites, and the pantocins. The important iminosugar alkaloids lentiginosine, steviamine, swainsonine, castanospermine, and related hydroxyindolizidines are dealt with in the subsequent section. The fourth and fifth sections cover metabolites from terrestrial plants. Pertinent plant alkaloids bearing alkyl, functionalized alkyl or alkenyl substituents include dendroprimine, anibamine, simple alkaloids belonging to the genera Prosopis, Elaeocarpus, Lycopodium, and Poranthera, and bicyclic alkaloids of the lupin family. Plant alkaloids bearing aryl or heteroaryl substituents include ipalbidine and analogs, secophenanthroindolizidine and secophenanthroquinolizidine alkaloids (among them septicine, julandine, and analogs), ficuseptine, lasubines, and other simple quinolizidines of the Lythraceae, the simple furyl-substituted Nuphar alkaloids, and a mixed quinolizidine-quinazoline alkaloid. The penultimate section of the review deals with the sizable group of simple indolizidine and quinolizidine alkaloids isolated from, or detected in, ants, mites, and terrestrial amphibians, and includes an overview of the "dietary hypothesis" for the origin of the amphibian metabolites. The final section surveys relevant alkaloids from marine sources, and includes clathryimines and analogs, stellettamides, the clavepictines and pictamine, and bis

  4. Treatment of triple-negative breast cancer with Chinese herbal medicine: A prospective cohort study protocol.

    Science.gov (United States)

    Meng, Hui; Peng, Nan; Yu, Mingwei; Sun, Xu; Ma, Yunfei; Yang, Guowang; Wang, Xiaomin

    2017-11-01

    Triple-negative breast cancer (TNBC) is featured with the biological properties of strong aggressive behaviors, rapid disease progression, high risk of recurrence and metastasis, and low disease free survival. Patients with this tumor are insensitive to the endocrine therapy and target treatment for HER-2; therefore, chemotherapy is often used as routine treatment in clinical. Because of the fact that a considerable number of patients seek for Chinese herbal medicine (CHM) treatment after operation and chemotherapy and (or) radiotherapy, it is thus need to evaluate the correlation between Chinese herbal medicine treatment and prognosis. This is a multicenter, prospective cohort study started in March 2016 in Beijing. A simple of 220 participants diagnosed with TNBC were recruited from nine hospitals and are followed up every 3 to 6 months till March 2020. Detailed information of participants includes personal information, history of cancer, quality of life, symptoms of traditional Chinese medicine and fatigue status is taken face-to-face at baseline. The study has received ethical approval from the Research Ethical Committee of Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University (No.2016BL-014-01). Articles summarizing the primary results and ancillary analyses will be published in peer-reviewed journals. Chinese Clinical Trial Registry: ChiCTR-OOC-16008246.

  5. The Ethical Perceptions of Elementary School Teachers in the Triple Perspective of Classification of Ethics

    Directory of Open Access Journals (Sweden)

    Sıtar Keser

    2013-03-01

    Full Text Available The ethical classification that forms the basis for this research uses a triple classification slightly different from the traditional approaches: “Consistency”, “Results” and “Caring”. With this classification it is stated that in handling the actions with an ethical approach, all three aspects are necessary. This study was conducted as a qualitative research and interview method was used to collect the research data. Study group consists of 10 volunteer elementary school teachers. The findings of the study reveal that the teachers who took part in this research took into consideration each of the factors “consistency”, “results” and “caring” sometimes singly, sometimes two of them together or sometimes three of them together. In addition, it is possible to indicate that different factors come to the forefront in different incidents that have similar characteristics, indicating that in this sense there is not a simple or single ethical stance in operation. From an ethical point of view, our actions are also influenced by our society’s norms, from the principles that come into existence over time and from the roles that we assume in the social domain

  6. Bridging disparate symptoms of schizophrenia: a triple network dysfunction theory.

    Science.gov (United States)

    Nekovarova, Tereza; Fajnerova, Iveta; Horacek, Jiri; Spaniel, Filip

    2014-01-01

    Schizophrenia is a complex neuropsychiatric disorder with variable symptomatology, traditionally divided into positive and negative symptoms, and cognitive deficits. However, the etiology of this disorder has yet to be fully understood. Recent findings suggest that alteration of the basic sense of self-awareness may be an essential distortion of schizophrenia spectrum disorders. In addition, extensive research of social and mentalizing abilities has stressed the role of distortion of social skills in schizophrenia.This article aims to propose and support a concept of a triple brain network model of the dysfunctional switching between default mode and central executive network (CEN) related to the aberrant activity of the salience network. This model could represent a unitary mechanism of a wide array of symptom domains present in schizophrenia including the deficit of self (self-awareness and self-representation) and theory of mind (ToM) dysfunctions along with the traditional positive, negative and cognitive domains. We review previous studies which document the dysfunctions of self and ToM in schizophrenia together with neuroimaging data that support the triple brain network model as a common neuronal substrate of this dysfunction.

  7. Bridging disparate symptoms of schizophrenia: a Triple network dysfunction theory

    Directory of Open Access Journals (Sweden)

    Tereza eNekovarova

    2014-05-01

    Full Text Available Schizophrenia is a complex neuropsychiatric disorder with variable symptomatology, traditionally divided into positive and negative symptoms, and cognitive deficits. Yet, the etiology of this disorder has yet to be fully understood.Recent findings suggest that alteration of the basic sense of self-awareness may be an essential distortion of schizophrenia spectrum disorders. In addition, extensive research of social and mentalizing abilities has stressed the role of distortion of social skills in schizophrenia.This article aims to propose and support a concept of triple brain network model of the dysfunctional switching between default mode and central executive network related to the aberrant activity of salience network. This model could represent a unitary mechanism of a wide array of symptom domains present in schizophrenia including the deficit of SELF (self-awareness and self-representation and theory of mind (ToM dysfunctions along with the traditional positive, negative and cognitive domains. We review previous studies which document the dysfunctions of SELF and ToM in schizophrenia together with neuroimaging data elucidating the triple brain network model as a common neuronal substrate of this dysfunction.

  8. Triple Difference Approach to Low Earth Orbiter Precision Orbit Determination

    Science.gov (United States)

    Kwon, Jay-Hyoun; Grejner-Brzezinska, Dorota A.; Yom, Jae-Hong; Cheon, Lee-Dong

    2003-03-01

    A precise kinematic orbit determination (P-KOD) procedure for Low Earth Orbiter(LEO) using the GPS ion-free triple differenced carrier phases is presented. Because the triple differenced observables provide only relative information, the first epoch's positions of the orbit should be held fixed. Then, both forward and backward filtering was executed to mitigate the effect of biases of the first epoch's position. P-KOD utilizes the precise GPS orbits and ground stations data from International GPS Service (IGS) so that the only unknown parameters to be solved are positions of the satellite at each epoch. Currently, the 3-D accuracy of P-KOD applied to CHAMP (CHAllenging Minisatellite Payload) shows better than 35 cm compared to the published rapid scientific orbit (RSO) solution from GFZ (GeoForschungsZentrum Potsdam). The data screening for cycle slips is a particularly challenging procedure for LEO, which moves very fast in the middle of the ionospheric layer. It was found that data screening using SNR (signal to noise ratio) generates best results based on the residual analysis using RSO. It is expected that much better accuracy are achievable with refined prescreening procedure and optimized geometry of the satellites and ground stations.

  9. Are the triple surface plasmon resonances in Zn nanoparticles true?

    Science.gov (United States)

    Amekura, H.; Shinotsuka, H.; Yoshikawa, H.

    2017-12-01

    It has been experimentally and numerically confirmed that zinc (Zn) nanoparticles (NPs) dispersed in silica exhibit two optical extinction peaks around ∼250 nm (1st peak) and ∼1050 nm (2nd peak), both of which were ascribed to surface plasmon resonances (SPRs) in the broad sense, i.e., the dual SPRs. Recently, Kuiri and Majhi (KM) observed the 3rd peak around ∼900 nm by calculations, and proposed the triple SPRs for Zn NPs without any experimental confirmation. This paper claims that the 3rd peak has never been observed in any experiments nor in any calculations except given by KM. They justified the triple resonances from an approximated SPR criterion, ε 1 Zn(ω) + 2ε 1 SiO2 (ω) = 0, which is not valid for non-idealized metals like Zn, because the imaginary part of the dielectric function ε 2 Zn(ω) is not negligible. Instead, a rigorous SPR criterion predicts the dual resonances only. From comparisons with ab initio band calculations, the 1st and 2nd extinction peak are ascribed to resonantly enhanced inter-band transitions (so-called electronic resonance) and intra-band transitions (SPR in the narrow sense), respectively. Since either of the peaks arises from the resonant enhancement due to the dielectric function, both the peaks are regarded as SPRs in the broad sense, i.e. the dual SPRs.

  10. "Triple-bottom-line" assessment of urban stormwater projects.

    Science.gov (United States)

    Taylor, A C; Fletcher, T D

    2006-01-01

    New guidelines have been developed and trialled in Australia to assist urban stormwater managers to assess options for projects that aim to improve urban waterway health. These guidelines help users to examine the financial, ecological and social dimensions of projects (i.e., the so-called "triple-bottom-line"). Features of the assessment process described in the guidelines include use of multi criteria analysis, input from technical experts as well as non-technical stakeholders, and provision of three alternative levels of assessment to suit stormwater managers with differing needs and resources. This paper firstly provides a background to the new guidelines and triple-bottom-line assessment. The assessment methodology promoted in the new guidelines is then briefly summarised. This methodology is compared and contrasted with European guidelines from the "SWARD" project that have been primarily developed for assessing the relative sustainability of options involving urban water supply and sewerage assets. Finally, the paper discusses how assessment methodologies that evaluate the financial, ecological and social dimensions of projects can, under some circumstances, be used to evaluate the relative progress of options for urban water management on a journey towards the widely pursued, but vaguely defined goal of "sustainable development".

  11. Use of locking plate and screws for triple pelvic osteotomy.

    Science.gov (United States)

    Rose, Scott A; Bruecker, Ken A; Petersen, Steve W; Uddin, Nizam

    2012-01-01

    To evaluate the efficacy and complication rate associated with use of a purpose-specific locking triple pelvic osteotomy (LTPO) plate. Prospective study. Dogs (n = 9; 15 hips). Physical examination, plain film radiography, computed tomography (CT) of the pelvis, and coxofemoral arthroscopy were performed before unilateral triple pelvic osteotomy (TPO) or staged bilateral TPO. Radiographs were taken after each procedure and 3-5, 6-8, and ≥12 weeks postoperatively. Pelvic width was measured at 3 locations to evaluate pelvic canal narrowing. No screw loosening occurred. Complications occurred in only 1 hip (7%) where pullout of the locking plate-screw construct from the caudal iliac segment occurred because of a fracture of the cis-cortex; the dog made a full recovery after a salvage procedure. There was no significant reduction in the cranial pelvic width but a small reduction at the level of the acetabuli and ischiatic tuberosities was noted 3-5 weeks after the 2nd TPO. The LTPO plate was associated with a lower complication rate than previously reported for TPOs using Slocum canine pelvic osteotomy plates (CPOP) and warrants further investigation. Pullout of the caudal plate-screw construct is a complication specific to LTPO implants. Bicortical screw purchase is recommended to prevent fracture of the cis-cortex and implant pullout. © Copyright 2011 by The American College of Veterinary Surgeons.

  12. Dynamic Triple-Mode Sorption and Outgassing in Materials.

    Science.gov (United States)

    Sharma, Hom N; Harley, Stephen J; Sun, Yunwei; Glascoe, Elizabeth A

    2017-06-07

    Moisture uptake and outgassing can be detrimental to a system by altering the chemical and mechanical properties of materials within the system over time. In this work, we conducted isotherm experiments to investigate dynamic moisture sorption and desorption in markedly different materials, i.e., a polymeric material, Sylgard-184 and a ceramic aluminosilicate material, Zircar RS-1200, at different temperatures (30 °C-70 °C) by varying the water activity (0.0-0.90). Sylgard-184 showed a linear sorption and outgassing behavior with no-hysteresis over the entire temperature and water activity range considered here. Whereas, the sorption and outgassing of Zircar RS-1200 was highly non-linear with significant hysteresis, especially at higher water activities, at all temperatures considered here. The type of hysteresis suggested the presence of mesopores in Zircar RS-1200, whereas the lack of hysteresis in Sylgard-184 indicates that it has a nonporous structure. A diffusion model coupled with a dynamic, triple-mode sorption (Langmuir, Henry, and pooling modes) model employed in this study matched our experimental data very well and provides mechanistic insight into the processes. Our triple-mode sorption model was adaptive enough to (1) model these distinctly different materials and (2) predict sorption and outgassing under conditions that are distinctly different from the parameterization experiments.

  13. Simple Electromagnetic Analysis in Cryptography

    Directory of Open Access Journals (Sweden)

    Zdenek Martinasek

    2012-07-01

    Full Text Available The article describes the main principle and methods of simple electromagnetic analysis and thus provides an overview of simple electromagnetic analysis.The introductions chapters describe specific SPA attack used visual inspection of EM traces, template based attack and collision attack.After reading the article, the reader is sufficiently informed of any context of SEMA.Another aim of the article is the practical realization of SEMA which is focused on AES implementation.The visual inspection of EM trace of AES is performed step by step and the result is the determination of secret key Hamming weight.On the resulting EM trace, the Hamming weight of the secret key 1 to 8 was clearly visible.This method allows reduction from the number of possible keys for following brute force attack.

  14. Simple techniques can increase motivation

    Energy Technology Data Exchange (ETDEWEB)

    Smith, E.A.

    1982-12-01

    Productivity depends upon strong motivation. This article describes how the symptoms of weak motivation can be detected among engineers and other employees and what to do about it. Fortunately, most people want to be productive and respond to simple motivation building techniques. These techniques include establishing twoway communication between supervisor and subordinate, delegating authority on the basis of responsibility, effective organization of time, and the use of positive reinforcement (or rewards) and, when conditions merit it, negative reinforcement (or sanctions).

  15. A simple electron plasma wave

    Energy Technology Data Exchange (ETDEWEB)

    Brodin, G., E-mail: gert.brodin@physics.umu.se [Department of Physics, Umeå University, SE-901 87 Umeå (Sweden); Stenflo, L. [Department of Physics, Linköping University, SE-581 83 Linköping (Sweden)

    2017-03-18

    Considering a class of solutions where the density perturbations are functions of time, but not of space, we derive a new exact large amplitude wave solution for a cold uniform electron plasma. This result illustrates that most simple analytical solutions can appear even if the density perturbations are large. - Highlights: • The influence of large amplitude electromagnetic waves on electrostatic oscillations is found. • A generalized Mathieu equation is derived. • Anharmonic wave profiles are computed numerically.

  16. Instant simple botting with PHP

    CERN Document Server

    Anderson, Shay Michael

    2013-01-01

    do for you, and then get to work with the most important features and tasks. This book is a hands-on Starter guide that takes the reader from initialization to the coding and implementation of bot apps.Instant Simple Botting with PHP targets programmers of all levels who are familiar with common PHP functions and syntax, and who want to learn about bots and how to design and develop bots using objects.

  17. SIMPLE Dark Matter Search Results

    CERN Document Server

    Girard, T A; Morlat, T; Costa, M F; Collar, J I; Limagne, D; Waysand, G; Puibasset, J; Miley, H S; Auguste, M; Boyer, D; Cavaillou, A; Marques, J G; Oliveira, C; Felizardo, M; Fernandes, A C; Ramos, A R; Martins, R C; Girard, TA

    2005-01-01

    We report an improved SIMPLE experiment comprising four superheated droplet detectors with a total exposure of 0.42 kgd. The result yields ~ factor 10 improvement in the previously-reported results, and -- despite the low exposure -- is seen to provide restrictions on the allowed phase space of spin-dependent coupling strengths almost equivalent to those from the significantly larger exposure NAIADCDMS/ZEPLIN searches.

  18. Simple and Realistic Data Generation

    DEFF Research Database (Denmark)

    Pedersen, Kenneth Houkjær; Torp, Kristian; Wind, Rico

    2006-01-01

    This paper presents a generic, DBMS independent, and highly extensible relational data generation tool. The tool can efficiently generate realistic test data for OLTP, OLAP, and data streaming applications. The tool uses a graph model to direct the data generation. This model makes it very simple...... to generate data even for large database schemas with complex inter- and intra table relationships. The model also makes it possible to generate data with very accurate characteristics....

  19. Classification of simple current invariants

    CERN Document Server

    Gato-Rivera, Beatriz

    1992-01-01

    We summarize recent work on the classification of modular invariant partition functions that can be obtained with simple currents in theories with a center (Z_p)^k with p prime. New empirical results for other centers are also presented. Our observation that the total number of invariants is monodromy-independent for (Z_p)^k appears to be true in general as well. (Talk presented in the parallel session on string theory of the Lepton-Photon/EPS Conference, Geneva, 1991.)

  20. Simple waves in Hertzian chains.

    Science.gov (United States)

    McDonald, B Edward; Calvo, David

    2012-06-01

    The discrete system of equations for a chain consisting of a large number of spheres interacting via the Hertz force of index 3/2 in strain is examined in the very long wavelength limit, yielding an effective medium description. The resulting continuum second-order equation of motion possesses a subset of simple waves obeying a first-order equation of reduced index 5/4. These simple waves appear not to have examined before. For a given initial strain, the simple wave solution prescribes initial sphere centroid velocities. Together the initial strain and velocities are used in the second-order discrete system. Results for shock wave development compare very well between the second-order discrete system (minus physically valid oscillations) and the reduced first-order equation. A second-order simulation of colliding waves examines the ability of waves to pass through each other, with a phase advance accruing during the collision process. An arbitrary initial condition is shown to evolve toward a universal similarity solution proportional to (x/t)(4). A closed-form solution is given including the complete history of the waveform, shock location, and amplitude.

  1. Oral tranexamic acid with fluocinolone-based triple combination cream versus fluocinolone-based triple combination cream alone in melasma: An open labeled randomized comparative trial

    OpenAIRE

    Tanmay Padhi; Swetalina Pradhan

    2015-01-01

    Background : Melasma is a common acquired cause of facial hyperpigmentation with no definitive therapy. Tranexamic acid, a plasmin inhibitor, has demonstrated depigmenting properties and combining this oral drug with other modalities of treatment has shown promising results. Objectives : To compare the efficacy of a combination of oral tranexamic acid and fluocinolone-based triple combination cream with that of fluocinolone-based triple combination cream alone in melasma among Indian patients...

  2. Nanostructured thin films for multiband-gap silicon triple junction solar cells

    NARCIS (Netherlands)

    Schropp, R.E.I.; Li, H. B. T.; Franken, R.H.; Rath, J.K.; van der Werf, C.H.M.; Schuttauf, J.A.; Stolk, R.L.

    2008-01-01

    By implementing nanostructure in multiband-gap proto-Si/proto-SiGe/nc-Si:H triple junction n–i–p solar cells, a considerable improvement in performance has been achieved. The unalloyed active layers in the top and bottom cell of these triple junction cells are deposited by Hot-Wire CVD. A

  3. Dirac operators and spectral triples for some fractal sets built on curves

    DEFF Research Database (Denmark)

    Christensen, Erik; Ivan, Cristina; Lapidus, Michel L.

    2008-01-01

    A spectral triple is an object which is described using an algebra of operators on a Hilbert space and an unbounded self-adjoint operator, called a Dirac operator. This model may be applied to the study of classical geometrical objects .The article contains a construction of a spectral triple...

  4. Risk of regional recurrence in triple-negative breast cancer patients: a Dutch cohort study

    NARCIS (Netherlands)

    Roozendaal, L.M. van; Smit, L.H.; Duijsens, G.H.; Vries, B. de; Siesling, S.; Lobbes, M.B.; Boer, M. de; Wilt, J.H.W. de; Smidt, M.L.

    2016-01-01

    Triple-negative breast cancer is associated with early recurrence and low survival rates. Several trials investigate the safety of a more conservative approach of axillary treatment in clinically T1-2N0 breast cancer. Triple-negative breast cancer comprises only 15 % of newly diagnosed breast

  5. Software-Enabled Project Management Techniques and Their Relationship to the Triple Constraints

    Science.gov (United States)

    Elleh, Festus U.

    2013-01-01

    This study investigated the relationship between software-enabled project management techniques and the triple constraints (time, cost, and scope). There was the dearth of academic literature that focused on the relationship between software-enabled project management techniques and the triple constraints (time, cost, and scope). Based on the gap…

  6. Quantum theory analysis of triple photons generated by a χ(3) process

    Science.gov (United States)

    Dot, A.; Borne, A.; Boulanger, B.; Bencheikh, K.; Levenson, J. A.

    2012-02-01

    We present a quantum theoretical analysis of triple photons generated by a phase-matched third-order nonlinear process in a KTP crystal in a weak-interaction regime. We show that the quantum properties of the triple photons can be brought to light through optical second- and third-order sum frequency generation processes.

  7. The triple assessment in the pre-operative evaluation of patients ...

    African Journals Online (AJOL)

    Background: Triple assessment has been recommended in diagnosis of Breast cancer in Uganda. This review analyses its diagnostic value in patients presenting with clinically malignant breast lumps. Objective: To establish the validity and reliability of the triple assessment in the pre-operative evaluation of patients with ...

  8. Effectiveness of the Triple P Positive Parenting Program on Parenting: A Meta-Analysis

    Science.gov (United States)

    de Graaf, Ireen; Speetjens, Paula; Smit, Filip; de Wolff, Marianne; Tavecchio, Louis

    2008-01-01

    Triple P is a parenting program intended to prevent and to provide treatment for severe behavioral, emotional, and developmental problems in children. The aim of this meta-analysis was to assess the effectiveness of Triple P Level 4 interventions on parenting styles and parental competency. Level 4 is an intensive training program of 8-10 sessions…

  9. Factsheet voor de beroepspraktijk: De effectiviteit van Triple P. Stand van zaken 2015.

    NARCIS (Netherlands)

    R. Schappin; I. de Graaf

    2015-01-01

    Een VIMP (verspreiding- en implementatie-impuls) van ZonMw. In de ‘Factsheet: De effectiviteit van Triple P. Stand van zaken 2015’ zijn de resultaten van het beschikbare onderzoek rondom Triple P, een programma voor opvoedingsondersteuning, samengevat. De factsheet is een samenwerking van het

  10. The effectiveness of lifestyle triple P in the Netherlands : A randomized controlled trial

    NARCIS (Netherlands)

    Gerards, Sanne M P L; Dagnelie, Pieter C.; Gubbels, Jessica S.; Van Buuren, Stef|info:eu-repo/dai/nl/074806777; Hamers, Femke J M; Jansen, Maria W J; Van Der Goot, Odilia H M; De Vries, Nanne K.; Sanders, Matthew R.; Kremers, Stef P J

    2015-01-01

    Introduction Lifestyle Triple P is a general parenting intervention which focuses on preventing further excessive weight gain in overweight and obese children. The objective of the current study was to assess the effectiveness of the Lifestyle Triple P intervention in the Netherlands. Method We used

  11. The effectiveness of lifestyle triple P in the Netherlands: A randomized controlled trial

    NARCIS (Netherlands)

    Gerards, S.M.P.L.; Dagnelie, P.C.; Gubbels, J.S.; Buuren, S. van; Hamers, F.J.M.; Jansen, M.W.J.; Goot, O.H.M. van der; Vries, N.K. de; Sanders, M.R.; Kremers, S.P.J.

    2015-01-01

    Introduction Lifestyle Triple P is a general parenting intervention which focuses on preventing further excessive weight gain in overweight and obese children. The objective of the current study was to assess the effectiveness of the Lifestyle Triple P intervention in the Netherlands. Method We used

  12. Effectiveness of the triple P positive parenting program on parenting: A meta-analysis

    NARCIS (Netherlands)

    Graaf, I. de; Speetjens, P.; Smit, F.; Wolff, M. de; Tavecchio, L.

    2008-01-01

    Triple P is a parenting program intended to prevent and to provide treatment for severe behavioral, emotional, and developmental problems in children. The aim of this meta-analysis was to assess the effectiveness of Triple P Level 4 interventions on parenting styles and parental competency. Level 4

  13. The determinant bundle on the moduli space of stable triples over a ...

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    bundles over a Riemann surface and also on the existence of a special metric on a stable triple established in [BG]. Here is a brief outline of the contents of the paper. In §2, we recall the basic notions about holomorphic triples, their stability, and their moduli spaces. In §3, we construct a natural holomorphic line bundle L on ...

  14. Helicobacter pylori second-line rescue therapy with levofloxacin- and bismuth-containing quadruple therapy, after failure of standard triple or non-bismuth quadruple treatments.

    Science.gov (United States)

    Gisbert, J P; Romano, M; Gravina, A G; Solís-Muñoz, P; Bermejo, F; Molina-Infante, J; Castro-Fernández, M; Ortuño, J; Lucendo, A J; Herranz, M; Modolell, I; Del Castillo, F; Gómez, J; Barrio, J; Velayos, B; Gómez, B; Domínguez, J L; Miranda, A; Martorano, M; Algaba, A; Pabón, M; Angueira, T; Fernández-Salazar, L; Federico, A; Marín, A C; McNicholl, A G

    2015-04-01

    The most commonly used second-line Helicobacter pylori eradication regimens are bismuth-containing quadruple therapy and levofloxacin-containing triple therapy, both offering suboptimal results. Combining bismuth and levofloxacin may enhance the efficacy of rescue eradication regimens. To evaluate the efficacy and tolerability of a second-line quadruple regimen containing levofloxacin and bismuth in patients whose previous H. pylori eradication treatment failed. This was a prospective multicenter study including patients in whom a standard triple therapy (PPI-clarithromycin-amoxicillin) or a non-bismuth quadruple therapy (PPI-clarithromycin-amoxicillin-metronidazole, either sequential or concomitant) had failed. Esomeprazole (40 mg b.d.), amoxicillin (1 g b.d.), levofloxacin (500 mg o.d.) and bismuth (240 mg b.d.) was prescribed for 14 days. Eradication was confirmed by (13) C-urea breath test. Compliance was determined through questioning and recovery of empty medication envelopes. Incidence of adverse effects was evaluated by questionnaires. 200 patients were included consecutively (mean age 47 years, 67% women, 13% ulcer). Previous failed therapy included: standard clarithromycin triple therapy (131 patients), sequential (32) and concomitant (37). A total of 96% took all medications correctly. Per-protocol and intention-to-treat eradication rates were 91.1% (95%CI = 87-95%) and 90% (95%CI = 86-94%). Cure rates were similar regardless of previous (failed) treatment or country of origin. Adverse effects were reported in 46% of patients, most commonly nausea (17%) and diarrhoea (16%); 3% were intense but none was serious. Fourteen-day bismuth- and levofloxacin-containing quadruple therapy is an effective (≥90% cure rate), simple and safe second-line strategy in patients whose previous standard triple or non-bismuth quadruple (sequential or concomitant) therapies have failed. © 2015 John Wiley & Sons Ltd.

  15. GDC-0941 and Cisplatin in Treating Patients With Androgen Receptor-Negative Triple Negative Metastatic Breast Cancer

    Science.gov (United States)

    2017-05-22

    Estrogen Receptor Negative Breast Cancer; Human Epidermal Growth Factor 2 Negative Carcinoma of Breast; Triple Negative Breast Cancer; Recurrent Breast Cancer; Stage IV Breast Cancer; Triple-negative Breast Cancer

  16. Simple and inexpensive microfluidic devices for the generation of monodisperse multiple emulsions

    KAUST Repository

    Li, Erqiang

    2013-12-16

    Droplet-based microfluidic devices have become a preferred versatile platform for various fields in physics, chemistry and biology. Polydimethylsiloxane soft lithography, the mainstay for fabricating microfluidic devices, usually requires the usage of expensive apparatus and a complex manufacturing procedure. Here, we report the design and fabrication of simple and inexpensive microfluidic devices based on microscope glass slides and pulled glass capillaries, for generating monodisperse multiple emulsions. The advantages of our method lie in a simple manufacturing procedure, inexpensive processing equipment and flexibility in the surface modification of the designed microfluidic devices. Different types of devices have been designed and tested and the experimental results demonstrated their robustness for preparing monodisperse single, double, triple and multi-component emulsions. © 2014 IOP Publishing Ltd.

  17. A simple method for the analysis of urinary sucralose for use in tests of intestinal permeability.

    Science.gov (United States)

    Anderson, A D G; Poon, P; Greenway, G M; MacFie, J

    2005-05-01

    Sucralose is a unique disaccharide probe which is stable in the colon and can be used to assess permeability over the whole gut. Additional information can be gained when sucralose is administered in combination with lactulose and a monosaccharide such as L-rhamnose in the form of a 'triple sugar test.' We describe a simple assay for urinary sucralose by HPLC with refractive index detection (HPLC-RI). Phenyl-beta-D-glucopyranoside (internal standard) was added to 10 mL of urine, which was then passed through a 0.45 microm syringe filter. Elution was with 30% methanol (1 mL/min) on a reverse-phase C18 column. Detection was by refractive index, and integration based upon peak areas. Sixty standards of sucralose in human urine were analysed in order to quantify analytical variation. The standard curve for urinary sucralose was linear from 25 to 500 mg/L (r>0.99). The limit of detection was 11 mg/L. Analytical recovery of sucralose at concentrations of 25, 50 and 100 mg/L was 101.5% (CV 7.59%), 102.9% (CV 5.82%) and 105.0% (CV 4.26%), respectively. The technique described represents a simple assay for urinary sucralose which performed with acceptable accuracy and precision and should facilitate the use of the triple sugar test in clinical research.

  18. What Is a Simple Liquid?

    Directory of Open Access Journals (Sweden)

    Trond S. Ingebrigtsen

    2012-03-01

    Full Text Available This paper is an attempt to identify the real essence of simplicity of liquids in John Locke’s understanding of the term. Simple liquids are traditionally defined as many-body systems of classical particles interacting via radially symmetric pair potentials. We suggest that a simple liquid should be defined instead by the property of having strong correlations between virial and potential-energy equilibrium fluctuations in the NVT ensemble. There is considerable overlap between the two definitions, but also some notable differences. For instance, in the new definition simplicity is not a direct property of the intermolecular potential because a liquid is usually only strongly correlating in part of its phase diagram. Moreover, not all simple liquids are atomic (i.e., with radially symmetric pair potentials and not all atomic liquids are simple. The main part of the paper motivates the new definition of liquid simplicity by presenting evidence that a liquid is strongly correlating if and only if its intermolecular interactions may be ignored beyond the first coordination shell (FCS. This is demonstrated by NVT simulations of the structure and dynamics of several atomic and three molecular model liquids with a shifted-forces cutoff placed at the first minimum of the radial distribution function. The liquids studied are inverse power-law systems (r^{-n} pair potentials with n=18,6,4, Lennard-Jones (LJ models (the standard LJ model, two generalized Kob-Andersen binary LJ mixtures, and the Wahnstrom binary LJ mixture, the Buckingham model, the Dzugutov model, the LJ Gaussian model, the Gaussian core model, the Hansen-McDonald molten salt model, the Lewis-Wahnstrom ortho-terphenyl model, the asymmetric dumbbell model, and the single-point charge water model. The final part of the paper summarizes properties of strongly correlating liquids, emphasizing that these are simpler than liquids in general. Simple liquids, as defined here, may be

  19. What Is a Simple Liquid?

    Science.gov (United States)

    Ingebrigtsen, Trond S.; Schrøder, Thomas B.; Dyre, Jeppe C.

    2012-01-01

    This paper is an attempt to identify the real essence of simplicity of liquids in John Locke’s understanding of the term. Simple liquids are traditionally defined as many-body systems of classical particles interacting via radially symmetric pair potentials. We suggest that a simple liquid should be defined instead by the property of having strong correlations between virial and potential-energy equilibrium fluctuations in the NVT ensemble. There is considerable overlap between the two definitions, but also some notable differences. For instance, in the new definition simplicity is not a direct property of the intermolecular potential because a liquid is usually only strongly correlating in part of its phase diagram. Moreover, not all simple liquids are atomic (i.e., with radially symmetric pair potentials) and not all atomic liquids are simple. The main part of the paper motivates the new definition of liquid simplicity by presenting evidence that a liquid is strongly correlating if and only if its intermolecular interactions may be ignored beyond the first coordination shell (FCS). This is demonstrated by NVT simulations of the structure and dynamics of several atomic and three molecular model liquids with a shifted-forces cutoff placed at the first minimum of the radial distribution function. The liquids studied are inverse power-law systems (r-n pair potentials with n=18,6,4), Lennard-Jones (LJ) models (the standard LJ model, two generalized Kob-Andersen binary LJ mixtures, and the Wahnstrom binary LJ mixture), the Buckingham model, the Dzugutov model, the LJ Gaussian model, the Gaussian core model, the Hansen-McDonald molten salt model, the Lewis-Wahnstrom ortho-terphenyl model, the asymmetric dumbbell model, and the single-point charge water model. The final part of the paper summarizes properties of strongly correlating liquids, emphasizing that these are simpler than liquids in general. Simple liquids, as defined here, may be characterized in three quite

  20. DEINDUSTRIALISASI SEBUAH ANCAMAN KEGAGALAN TRIPLE TRACK STRATEGY PEMBANGUNAN DI INDONESIA

    Directory of Open Access Journals (Sweden)

    P. Eko Prasetyo

    2015-12-01

    Full Text Available SBY government work effort through the triple-track strategy namely pro-growth, pro jobs and pro-poor developments will be doomed to fail because of a deindustrialization inIndonesia. The phenomenon of deindustrialization is characterized by the continued decline of industrial contribution mainly manufacture industrial sektor to the value added, employment, exports and contribution to GDP growth, would obviously be a serious threat to the government in its efforts to achieve economic growth to reduce unemployment and poverty. Industrial sektor at this time was no longer regarded as a leading sektor in the national and regional development, so that if eagerly handled will have a negative impact more and could threaten the stability of the economic development of Indonesia.

  1. Tetraphenylporphyrin as a protein label for triple detection analytical systems

    Directory of Open Access Journals (Sweden)

    Kamila Konopińska

    2015-12-01

    Full Text Available Porphyrins and metalloporphyrins are promising new protein labels that can be detected using multiple techniques; improving the reliability of the analysis and broadening the range of the linear response. Here, we investigate the potential of 5,10,15,20-tetraphenyl-21H,23H-porphyrin (Tpp as a hybrid protein label. The electrochemical and optical properties of porphyrin conjugated with bovine serum albumin (BSA, chicken egg albumin (CEA and immunoglobulin G (IgG were determined and optimal conditions for Tpp-protein conjugation established. Model conjugates of carboxylated Tpp with BSA and short peptides were characterized using differential pulse voltammetry, UV–Vis spectrophotometry and spectrofluorimetry. These results reveal that Tpp is a promising molecule to be used in a triple detection protein labelling system.

  2. Concurrent triple-scale simulation of molecular liquids

    Science.gov (United States)

    Delgado-Buscalioni, Rafael; Kremer, Kurt; Praprotnik, Matej

    2008-03-01

    We present a triple-scale simulation of a molecular liquid, in which the atomistic, coarse-grained, and continuum descriptions of the liquid are concurrently coupled. The presented multiscale approach, which covers the length scales ranging from the micro- to macroscale, is a combination of two dual-scale models: a particle-based adaptive resolution scheme (AdResS), which couples the atomic and mesoscopic scales, and a hybrid continuum-molecular dynamics scheme (HybridMD). The combined AdResS-HybridMD scheme successfully sorts out the problem of large molecule insertion in the hybrid particle-continuum simulations of molecular liquids. The combined model is shown to correctly describe the hydrodynamics within a hybrid particle-continuum framework. The presented approach opens up the possibility to perform efficient grand-canonical molecular dynamics simulations of truly open molecular liquid systems.

  3. A triple quantum dot based nano-electromechanical memory device

    Energy Technology Data Exchange (ETDEWEB)

    Pozner, R.; Lifshitz, E. [Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa 32000 (Israel); Solid State Institute, Technion-Israel Institute of Technology, Haifa 32000 (Israel); Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa 32000 (Israel); Peskin, U., E-mail: uri@tx.technion.ac.il [Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa 32000 (Israel); Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa 32000 (Israel); Lise Meitner Center for Computational Quantum Chemistry, Technion-Israel Institute of Technology, Haifa 32000 (Israel)

    2015-09-14

    Colloidal quantum dots (CQDs) are free-standing nano-structures with chemically tunable electronic properties. This tunability offers intriguing possibilities for nano-electromechanical devices. In this work, we consider a nano-electromechanical nonvolatile memory (NVM) device incorporating a triple quantum dot (TQD) cluster. The device operation is based on a bias induced motion of a floating quantum dot (FQD) located between two bound quantum dots (BQDs). The mechanical motion is used for switching between two stable states, “ON” and “OFF” states, where ligand-mediated effective interdot forces between the BQDs and the FQD serve to hold the FQD in each stable position under zero bias. Considering realistic microscopic parameters, our quantum-classical theoretical treatment of the TQD reveals the characteristics of the NVM.

  4. Efficacy of Neoadjuvant Cisplatin in Triple-Negative Breast Cancer

    DEFF Research Database (Denmark)

    Szallasi, Zoltan Imre; Eklund, Aron Charles; Li, Qiyuan

    2010-01-01

    share features suggesting common pathogenesis, we conducted a neoadjuvant trial of cisplatin in TNBC and explored specific biomarkers to identify predictors of response. PATIENTS AND METHODS Twenty-eight women with stage II or III breast cancers lacking estrogen and progesterone receptors and HER2/Neu...... (TNBC) were enrolled and treated with four cycles of cisplatin at 75 mg/m(2) every 21 days. After definitive surgery, patients received standard adjuvant chemotherapy and radiation therapy per their treating physicians. Clinical and pathologic treatment response were assessed, and pretreatment tumor......PURPOSE Cisplatin is a chemotherapeutic agent not used routinely for breast cancer treatment. As a DNA cross-linking agent, cisplatin may be effective treatment for hereditary BRCA1-mutated breast cancers. Because sporadic triple-negative breast cancer (TNBC) and BRCA1-associated breast cancer...

  5. Infantile melanoma--a triple threat: diagnosis and management.

    Science.gov (United States)

    Lambie, Milena; Nadler, Chad; Glat, Paul; Van Duzer, Scott; Halligan, Gregory; Geller, Evan

    2011-07-01

    Cases of infantile melanoma are very rare, and only a few have been presented in the literature. Pediatric melanoma can present to the clinician as a "triple threat" of delayed diagnosis resulting in thick lesions at risk for metastasis, histologic uncertainty of diagnosis, and a lack of data guiding regional node management and adjuvant therapy. Melanoma in childhood is an uncommon condition, and it is even more atypical in infants. There is evidence however that it is increasing in frequency. We present 2 cases of infantile melanoma diagnosed before age 1 and multidisciplinary management performed at our institution. One child was diagnosed with melanoma arising within a congenital melanocytic nevus, and the other presented with melanoma from a de novo acquired scalp lesion. The ambiguity surrounding correct pathologic diagnosis of melanoma in this age group, and the tendency for late diagnosis with thicker lesions presents special staging and treatment challenges to the team of specialists involved in the care of these children.

  6. Peyronie’s disease: A “triple oxygenant therapy”

    Directory of Open Access Journals (Sweden)

    Francesco Ciociola

    2013-04-01

    Full Text Available Objectives: To evaluate the effects of upregulators of nitric oxide in one patient with Peyronie’s disease, after non significant improvement following intracavernosal verapamil. Methods: A 20-years-old Caucasian male presented with penile induration in flaccid state, persistent during erection and associated with mild pain at third middle of penis. After treatment with intracavernosal verapamil for 4 months with relief of penile discomfort, followed by counseling on the use of penile extender for at least 6 hours per day, he was prescribed pentoxifylline associated with tadalafil plus levo-arginine, propionil-carnitine and Vitamin B3. Results: After almost 2 years, the septal thickness was reduced at ultrasound evaluation after this “triple oxygenant therapy”. Conclusion: NO-iNOS biology in Peyronie patients is the very protagonist in modulating penile fibrosis through up-regulation of NO-cGMP pathway that influences penile health by preventing and reversing fibrosis in the tunical albuginea.

  7. Triple fracture during rehabilitation after revision total knee arthroplasty.

    Science.gov (United States)

    Meyer, Christof; Szalay, Gabor; Alt, Volker; Schnettler, Reinhard

    2014-11-01

    The incidence of periprosthetic fractures after knee-joint implant revisions is increasing in prevalence. We present a method of treatment for a patient who sustained a triple fracture--a periprosthetic femur fracture, a patella fracture, and a tibial shaft fracture. The femoral fracture was treated with a specially designed intramedullary nail, the patella fracture with a figure-of-eight suture, and the tibial shaft fracture by a minimal-invasive plate osteosynthesis using a percutaneous plating technique. Osseous consolidation was confirmed, and the patient presented a satisfying range of movement under full-weight-bearing conditions after mobilisation. Simultaneous multiple periprosthetic fractures are a special challenge, and in situ coupling of the endoprosthesis with a slotted hollow nail presents a valuable option for the treatment. Level V, Expert opinion.

  8. Gastric Metastasis of Triple Negative Invasive Lobular Carcinoma.

    Science.gov (United States)

    Geredeli, Caglayan; Dogru, Osman; Omeroglu, Ethem; Yilmaz, Farise; Cicekci, Faruk

    2015-05-05

    Invasive lobular carcinomas are the second most common type (5% to 15%) of invasive breast carcinomas. The most frequent sites of breast cancer metastasis are the local and distant lymph nodes, brain, lung, liver, and bones; metastasis to the gastrointestinal system, especially to the stomach, is rare. When a mass is detected in an unusual place in a patient with invasive lobular carcinoma, it should be kept in mind that such a mass may be either a second primary carcinoma or the metastasis of an invasive lobular carcinoma. In this report, we present a case of gastric metastasis from triple-negative invasive lobular breast cancer. It is important to make an accurate diagnosis by distinguishing gastric metastasis from breast cancer in order to select the best initial treatment for systemic diseases of breast cancer. Considering our case, healthcare professionals should take into account that cases with invasive lobular breast cancer may experience unusual metastases.

  9. Gravitational wave sirens as a triple probe of dark energy

    Energy Technology Data Exchange (ETDEWEB)

    Linder, Eric V, E-mail: evlinder@lbl.gov [Berkeley Laboratory, University of California, Berkeley, CA 94720 (United States)

    2008-03-15

    Gravitational wave standard sirens have been considered as precision distance indicators of high redshift; however, at high redshift standard sirens or standard candles such as supernovae suffer from lensing noise. We investigate lensing noise as a signal instead and show how measurements of the maximum demagnification (minimum convergence) probe cosmology in a manner highly complementary to the distance itself. Revisiting the original form for minimum convergence we quantify the bias arising from the commonly used approximation. Furthermore, after presenting a new lensing probability function we discuss how the width of the lensed standard siren amplitude distribution also probes growth of structure. Thus standard sirens and candles can serve as triple probes of dark energy, measuring both the cosmic expansion history and growth history.

  10. Gravitational wave sirens as a triple probe of dark energy

    Science.gov (United States)

    Linder, Eric V.

    2008-03-01

    Gravitational wave standard sirens have been considered as precision distance indicators of high redshift; however, at high redshift standard sirens or standard candles such as supernovae suffer from lensing noise. We investigate lensing noise as a signal instead and show how measurements of the maximum demagnification (minimum convergence) probe cosmology in a manner highly complementary to the distance itself. Revisiting the original form for minimum convergence we quantify the bias arising from the commonly used approximation. Furthermore, after presenting a new lensing probability function we discuss how the width of the lensed standard siren amplitude distribution also probes growth of structure. Thus standard sirens and candles can serve as triple probes of dark energy, measuring both the cosmic expansion history and growth history.

  11. Triple-Negative Breast Cancer: Adjuvant Therapeutic Options

    Directory of Open Access Journals (Sweden)

    Ayca Gucalp

    2011-01-01

    Full Text Available Triple-negative breast cancer (TNBC, a subtype distinguished by negative immunohistochemical assays for expression of the estrogen and progesterone receptors (ER/PR and human epidermal growth factor receptor-2(HER2 represents 15% of all breast cancers. Patients with TNBC generally experience a more aggressive clinical course with increased risk of disease progression and poorer overall survival. Furthermore, this subtype accounts for a disproportionate number of disease-related mortality in part due to its aggressive natural history and our lack of effective targeted agents beyond conventional cytotoxic chemotherapy. In this paper, we will review the epidemiology, risk factors, prognosis, and the molecular and clinicopathologic features that distinguish TNBC from other subtypes of breast cancer. In addition, we will examine the available data for the use of cytotoxic chemotherapy in the treatment of TNBC in both the neoadjuvant and adjuvant setting and explore the ongoing development of newer targeted agents.

  12. Efficient Triple Helix collaboration fostering local niche innovation projects

    DEFF Research Database (Denmark)

    Brem, Alexander; Radziwon, Agnieszka

    2017-01-01

    Collaboration between universities and their local stakeholders is becoming a key success factor for the growth of regional entrepreneurial ecosystems. Efficient energy solutions are often facing challenges in innovation diffusion, which is in contrast to the growing demand for providing answers...... to key ecological problems. In order to present how an efficient Triple Helix collaboration could foster and support niche innovations, an applied research project is introduced. This unique university-industry-government cooperation brings a students' idea to a proof-of-concept project thus covers...... the entire innovation process. The selected case offers insights of how and why such initiative could emerge, as well as discusses its implications for future technological innovations and in particular those that are about to emerge in regional entrepreneurial ecosystems. Networking, win...

  13. Triple-Vessel Percutaneous Coronary Revascularization In Situs Inversus Dextrocardia

    Directory of Open Access Journals (Sweden)

    Nikolaos Kakouros

    2010-01-01

    Full Text Available Dextrocardia with situs inversus occurs in approximately one in 10,000 individuals of whom 20% have primary ciliary dyskinesia inherited as an autosomal recessive trait. These patients have a high incidence of congenital cardiac disease but their risk of coronary artery disease is similar to that of the general population. We report what is, to our knowledge, the first case of total triple-vessel coronary revascularization by percutaneous stent implantation in a 79-year-old woman with situs inversus dextrocardia. We describe the successful use of standard diagnostic and interventional guide catheters with counter rotation and transversely inversed image acquisition techniques. The case also highlights that the right precordial pain may represent cardiac ischemia in this population.

  14. Computer electronics made simple computerbooks

    CERN Document Server

    Bourdillon, J F B

    1975-01-01

    Computer Electronics: Made Simple Computerbooks presents the basics of computer electronics and explains how a microprocessor works. Various types of PROMs, static RAMs, dynamic RAMs, floppy disks, and hard disks are considered, along with microprocessor support devices made by Intel, Motorola and Zilog. Bit slice logic and some AMD bit slice products are also described. Comprised of 14 chapters, this book begins with an introduction to the fundamentals of hardware design, followed by a discussion on the basic building blocks of hardware (NAND, NOR, AND, OR, NOT, XOR); tools and equipment that

  15. Nonlinear Pendulum: A Simple Generalization

    OpenAIRE

    Neto, J. P. Juchem

    2010-01-01

    In this work we solve the nonlinear second order differential equation of the simple pendulum with a general initial angular displacement ($\\theta(0)=\\theta_0$) and velocity ($\\dot{\\theta}(0)=\\phi_0$), obtaining a closed-form solution in terms of the Jacobi elliptic function $\\text{sn}(u,k)$, and of the the incomplete elliptical integral of the first kind $F(\\varphi,k)$. Such a problem can be used to introduce concepts like elliptical integrals and functions to advanced undergraduate students...

  16. Simple Simulations of DNA Condensation

    Energy Technology Data Exchange (ETDEWEB)

    STEVENS,MARK J.

    2000-07-12

    Molecular dynamics simulations of a simple, bead-spring model of semiflexible polyelectrolytes such as DNA are performed. All charges are explicitly treated. Starting from extended, noncondensed conformations, condensed structures form in the simulations with tetravalent or trivalent counterions. No condensates form or are stable for divalent counterions. The mechanism by which condensates form is described. Briefly, condensation occurs because electrostatic interactions dominate entropy, and the favored Coulombic structure is a charge ordered state. Condensation is a generic phenomena and occurs for a variety of polyelectrolyte parameters. Toroids and rods are the condensate structures. Toroids form preferentially when the molecular stiffness is sufficiently strong.

  17. Systems analysis made simple computerbooks

    CERN Document Server

    Antill, Lyn

    1980-01-01

    Systems Analysis: Made Simple Computerbooks introduces the essential elements of information systems analysis and design and teaches basic technical skills required for the tasks involved. The book covers the aspects to the design of an information system; information systems and the organization, including the types of information processing activity and computer-based information systems; the role of the systems analyst; and the human activity system. The text also discusses information modeling, socio-technical design, man-machine interface, and the database design. Software specification

  18. Simple laws of urban growth

    CERN Document Server

    Masucci, Paolo; Batty, Michael

    2012-01-01

    By analysing the evolution of the street network of Greater London from the late 1700s to the present, we are able to shed light on the inner mechanisms that lie behind the growth of a city. First we define an object called a city as a spatial discontinuous phenomena, from clustering the density of street intersections. Second, we find that the city growth mechanisms can be described by two logistic laws, hence can be determined by a simple model of urban network growth in the presence of competition for limited space.

  19. Windows Phone 7 Made Simple

    CERN Document Server

    Trautschold, Martin

    2011-01-01

    With Windows Phone 7, Microsoft has created a completely new smartphone operating system that focuses on allowing users to be productive with their smartphone in new ways, while offering seamless integration and use of Microsoft Office Mobile as well as other productivity apps available in the Microsoft App Store. Windows Phone 7 Made Simple offers a clear, visual, step-by-step approach to using your Windows Phone 7 smartphone, no matter what the manufacturer. Author Jon Westfall is an expert in mobile devices, recognized by Microsoft as a "Most Valuable Professional" with experience

  20. The TWA 3 Young Triple System: Orbits, Disks, Evolution

    Energy Technology Data Exchange (ETDEWEB)

    Kellogg, Kendra [Department of Physics and Astronomy, The University of Western Ontario, London, ON N6A 3K7 (Canada); Prato, L.; Avilez, I.; Wasserman, L. H.; Levine, S. E.; Bosh, A. S. [Lowell Observatory, 1400 West Mars Hill Road, Flagstaff, AZ 86001 (United States); Torres, Guillermo [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Schaefer, G. H. [The CHARA Array of Georgia State University, Mount Wilson Observatory, Mount Wilson, CA 91023 (United States); Ruíz-Rodríguez, D. [Research School of Astronomy and Astrophysics, Australian National University, Canberra, ACT 2611 (Australia); Bonanos, Alceste Z. [IAASARS, National Observatory of Athens, 15236 Penteli (Greece); Guenther, E. W. [Thüringer Landessternwarte Tautenburg, D-07778 Tautenburg (Germany); Neuhäuser, R. [Astrophysikalisches Institut und Universitäts-Sternwarte, FSU Jena, Schillergäßchen 2-3, D-07745 Jena (Germany); Morzinski, Katie M.; Close, Laird; Hinz, Phil; Males, Jared R. [Steward Observatory, University of Arizona, 933 N. Cherry Ave, Tucson, AZ 85721 (United States); Bailey, Vanessa, E-mail: kkellogg@uwo.ca, E-mail: lprato@lowell.edu [Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics, Stanford University, Stanford, CA, 94305 (United States)

    2017-08-01

    We have characterized the spectroscopic orbit of the TWA 3A binary and provide preliminary families of probable solutions for the TWA 3A visual orbit, as well as for the wide TWA 3A–B orbit. TWA 3 is a hierarchical triple located at 34 pc in the ∼10 Myr old TW Hya association. The wide component separation is 1.″55; the close pair was first identified as a possible binary almost 20 years ago. We initially identified the 35-day period orbital solution using high-resolution infrared spectroscopy that angularly resolved the A and B components. We then refined the preliminary orbit by combining the infrared data with a reanalysis of our high-resolution optical spectroscopy. The orbital period from the combined spectroscopic solution is ∼35 days, the eccentricity is ∼0.63, and the mass ratio is ∼0.84; although this high mass ratio would suggest that optical spectroscopy alone should be sufficient to identify the orbital solution, the presence of the tertiary B component likely introduced confusion in the blended optical spectra. Using millimeter imaging from the literature, we also estimate the inclinations of the stellar orbital planes with respect to the TWA 3A circumbinary disk inclination and find that all three planes are likely misaligned by at least ∼30°. The TWA 3A spectroscopic binary components have spectral types of M4.0 and M4.5; TWA 3B is an M3. We speculate that the system formed as a triple, is bound, and that its properties were shaped by dynamical interactions between the inclined orbits and disk.

  1. Vascular characterisation of triple negative breast carcinomas using dynamic MRI

    Energy Technology Data Exchange (ETDEWEB)

    Li, Sonia P.; Beresford, Mark J.; Ah-See, Mei-Lin W.; Makris, Andreas [Mount Vernon Cancer Centre, Academic Oncology Unit, Northwood, Middlesex (United Kingdom); Padhani, Anwar R.; Taylor, N.J.; Stirling, J.J. [Mount Vernon Hospital, Paul Strickland Scanner Centre, Northwood, Middlesex (United Kingdom); D' Arcy, James A.; Collins, David J. [Royal Marsden NHS Foundation Trust and Institute of Cancer Research, CR UK and EPSRC Cancer Imaging Centre, Sutton, Surrey (United Kingdom)

    2011-07-15

    Triple-negative (ER-/PR-/HER2-) breast carcinomas (TNBC) are aggressive tumours with underexplored imaging features. This study investigates whether their vascular characteristics as assessed by dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast-enhanced (DSC) MRI are distinct from the prognostically more favourable ER+/PR+/HER2- cancers. Patients with primary breast cancer underwent MRI before neoadjuvant chemotherapy and were identified as ER-/PR-/HER2- or ER+/PR+/HER2- from core biopsy specimens. MRI parameters reflecting tissue perfusion, permeability, and extracellular leakage space were measured. Values for inflow transfer constant (K{sup trans}), outflow rate constant (k{sub ep}), leakage space (v{sub e}), area under the gadolinium curve (IAUGC{sub 60}), relative blood volume (rBV) and flow (rBF), and Mean Transit Time (MTT) were compared across receptor status and with known prognostic variables. Thirty seven patients were assessable in total (16 ER-/PR-/HER2-, 21 ER+/PR+/HER2-). Lower v{sub e} (p = 0.001), shorter MTT (p = 0.007) and higher k{sub ep} values (p = 0.044) were observed in TNBC. v{sub e} was lower across all T stages, node-negative (p = 0.004) and low-grade TNBC (p = 0.037). v{sub e} was the best predictor of triple negativity (ROC AUC 0.80). TNBC possess characteristic features on imaging, with lower extracellular space (higher cell density) and higher contrast agent wash-out rate (higher vascular permeability) suggesting a distinctive phenotype detectable by MRI. (orig.)

  2. [Triple immunosuppressive therapy in the treatment of severe ulcerative colitis].

    Science.gov (United States)

    Castro, B; Crespo, J; García-Suárez, C; Fábrega, E; Casafont, F; Pons-Romero, F

    2004-01-01

    Severe episodes of steroid-refractory ulcerative colitis (UC) were considered an indication for surgery until the introduction of new immunosuppressive agents such as cyclosporine. 1) To confirm the efficacy of intravenous cyclosporine in inducing remission in severe episodes of steroid-refractory UC; 2) To analyze the efficacy of triple immunosuppressive therapy with cyclosporine, azathioprine and prednisone in the maintenance of remission induced by intravenous cyclosporine. Fourteen patients diagnosed with a severe episode of steroid-refractory UC were treated with intravenous cyclosporine at a dose of 4 mg/kg/day. In all patients, after response was induced, this regimen was substituted by oral cyclosporine plus azathioprine at a dose of 2-2.5 mg/kg/day and decreasing doses of corticoids. Neoral cyclosporine was progressively reduced until discontinuation within 3 months, coinciding with a simultaneous decrease of oral steroids. All patients showed response to intravenous cyclosporine with a significant reduction in the Truelove index calculated before and after treatment. After remission was induced, all patients followed triple immunosuppressive therapy for 3 months. In the follow-up for a mean of 24 months (range: 14-34) only two patients required admission for a new episode of UC and colectomy was finally indicated in only one. None of the 14 patients treated with cyclosporine showed severe adverse effects attributable to the drug. Intravenous cyclosporine is a safe and effective alternative in the treatment of severe episodes of steroid-refractory UC. Early initiation of oral administration associated with azathioprine is useful in maintaining response, reducing subsequent relapses and the need for colectomy during the follow-up of these patients.

  3. Persistent, triple-virus co-infections in mosquito cells

    Directory of Open Access Journals (Sweden)

    Malasit Prida

    2010-01-01

    Full Text Available Abstract Background It is known that insects and crustaceans can carry simultaneous, active infections of two or more viruses without showing signs of disease, but it was not clear whether co-infecting viruses occupied the same cells or different cells in common target tissues. Our previous work showed that successive challenge of mosquito cell cultures followed by serial, split-passage resulted in stabilized cultures with 100% of the cells co-infected with Dengue virus (DEN and an insect parvovirus (densovirus (DNV. By addition of Japanese encephalitis virus (JE, we tested our hypothesis that stable, persistent, triple-virus co-infections could be obtained by the same process. Results Using immunocytochemistry by confocal microscopy, we found that JE super-challenge of cells dually infected with DEN and DNV resulted in stable cultures without signs of cytopathology, and with 99% of the cells producing antigens of the 3 viruses. Location of antigens for all 3 viruses in the triple co-infections was dominant in the cell nuclei. Except for DNV, this differed from the distribution in cells persistently infected with the individual viruses or co-infected with DNV and DEN. The dependence of viral antigen distribution on single infection or co-infection status suggested that host cells underwent an adaptive process to accommodate 2 or more viruses. Conclusions Individual mosquito cells can accommodate at least 3 viruses simultaneously in an adaptive manner. The phenomenon provides an opportunity for genetic exchange between diverse viruses and it may have important medical and veterinary implications for arboviruses.

  4. Triple-negative breast cancer: new perspectives for targeted therapies

    Directory of Open Access Journals (Sweden)

    Tomao F

    2015-01-01

    Full Text Available Federica Tomao,1 Anselmo Papa,2 Eleonora Zaccarelli,2 Luigi Rossi,2 Davide Caruso,2 Marina Minozzi,2 Patrizia Vici,3 Luigi Frati,4 Silverio Tomao21Department of Gynecology and Obstetrics, “Sapienza” University of Rome, Policlinico “Umberto I”, Rome, 2Department of Medico-Surgical Sciences and Biotechnologies, “Sapienza” University of Rome, Oncology Unit, Istituto Chirurgico Ortopedico Traumatologico, Latina, 3Division of Medical Oncology B, Regina Elena National Cancer Institute, Rome, Italy; 4Department of Molecular Medicine, “Sapienza” University of Rome, Policlinico “Umberto I”, Rome, ItalyAbstract: Breast cancer is a heterogeneous disease, encompassing a large number of entities showing different morphological features and having clinical behaviors. It has became apparent that this diversity may be justified by distinct patterns of genetic, epigenetic, and transcriptomic aberrations. The identification of gene-expression microarray-based characteristics has led to the identification of at least five breast cancer subgroups: luminal A, luminal B, normal breast-like, human epidermal growth factor receptor 2, and basal-like. Triple-negative breast cancer is a complex disease diagnosed by immunohistochemistry, and it is characterized by malignant cells not expressing estrogen receptors or progesterone receptors at all, and human epidermal growth factor receptor 2. Along with this knowledge, recent data show that triple-negative breast cancer has specific molecular features that could be possible targets for new biological targeted drugs. The aim of this article is to explore the use of new drugs in this particular setting, which is still associated with poor prognosis and high risk of distant recurrence and death.Keywords: basal-like breast cancer, estrogen–progesterone receptors, gene-expression microarray, human epidermal growth factor receptor 2, chemotherapy, target therapy

  5. Evaluation of Helicobacter Pylori eradication in pediatric patients by triple therapy plus lactoferrin and probiotics compared to triple therapy alone

    Directory of Open Access Journals (Sweden)

    Tolone Salvatore

    2012-10-01

    Full Text Available Abstract Background To evaluate whether the addition of a probiotic could improve Helicobacter pylori (H.P. eradication rates and reduce the side effects of treatment in children. Methods Between July 2008 and July 2011 all patients with a clinical, laboratory and endoscopic diagnosis of H.P. positive gastritis referred to our Unit were included in the study. Patients suffering from allergy to any of drugs used in the study, with previous attempts to eradicate H.P. and those who received antibiotics, PPIs or probiotics within 4 weeks were excluded from the present study. Patients were randomized into two therapy regimens (group A and B: both groups received standard triple treatment (omeprazole, amoxicillin and clarithromycin while only group B patients were also given a probiotic (Probinul - Cadigroup. Patients compliance was evaluated at the end of the treatment. Successful eradication was defined as a negative 13 C-urea breath test (C13-ubt result four weeks after therapy discontinuation. Results A total of 68 histopathologically proven H.P.-infection children (32 male and 36 females were included in the study. All of the patients in both groups used more than 90% of the therapies and no patients were lost at follow up. All side effects were selflimiting and disappeared once the therapy was terminated. Epigastric pain was observed in 6 (17.6% group A vs 2 (5.8% group B patients (P Conclusion The addition of a probiotic formula to triple therapy significantly decreased the frequency of epigastric pain, nausea, vomiting and diarrhea.

  6. Arthroscopic rotator cuff repair using a triple-loaded suture anchor and a modified Mason-Allen technique (Alex stitch).

    Science.gov (United States)

    Castagna, Alessandro; Garofalo, Raffaele; Conti, Marco; Borroni, Mario; Snyder, Stephen J

    2007-04-01

    Surgical repair of the rotator cuff must have good resistance and should restore the tendon footprint. To attain this goal, a stitch with a strong biomechanical profile that avoids tissue strangulation should be used. We describe an arthroscopic suture technique undertaken to repair rotator cuff tears with a single triple-loaded suture anchor. The technique consists of a combination of a horizontal mattress and 2 vertical simple sutures that are positioned medial to the mattress suture. The suture anchor used is the 5-mm self-tapping ThRevo (Linvatec). This anchor is loaded with 3 sutures: 2 No. 2 nonabsorbable braided polyester sutures of different colors and a central high-strength No. 2 polyethylene suture. The shape of the anchor eyelet permits all 3 sutures to glide freely. A modified Mason-Allen technique (Alex stitch) that combines a horizontal side-to-side suture and 2 simples sutures as vertical loops is used. With use of the Spectrum suture passing device and shuttle relay system (Linvatec), both limbs of the centrally located polyethylene suture are passed through the cuff from bottom to top, approximately 1 cm from the tendon edge. This suture is not immediately tied. Next, with use of the same system, the other 2 sutures are placed medially and over the previous horizontal suture. Simple sutures are placed at an approximately 30 degrees angle from the center of the anchor; 1 is placed anterior and the other posterior. The sutures are tied through the lateral portal. The mattress horizontal central stitch is always tied first, followed by the 2 vertical sutures. The horizontal mattress suture serves as a "rip stop stitch" and theoretically reduces the possibility of cutting out of the simple sutures.

  7. Methadone radioimmunoassay: two simple methods

    Energy Technology Data Exchange (ETDEWEB)

    Robinson, K.; Smith, R.N. (Metropolitan Police Forensic Science Laboratory, London (UK))

    1983-09-01

    Two simple and economical radioimmunoassays for methadone in blood or urine are described. Haemolysis, decomposition, common anticoagulants and sodium fluoride do not affect the results. One assay used commercially-available (1-/sup 3/H)(-)-methadone hydrobromide as the label, while the other uses a radioiodinated conjugate of 4-dimethylamino-2,2-diphenylpentanoic acid and L-tyrosine methyl ester. A commercially-available antiserum is used in both assays. Normethadone and ..cap alpha..-methadol cross-react to a small extent with the antiserum while methadone metabolites, dextropropoxyphene, dipipanone and phenadoxone have negligible cross-reactivities. The 'cut-offs' of the two assays as described are 30 and 33 ng ml/sup -1/ for blood, and 24 and 21 ng ml/sup -1/ for urine. The assay using the radioiodinated conjugate can be made more sensitive if required by increasing the specific activity of the label.

  8. iPad Made Simple

    CERN Document Server

    Trautschold, Martin; Learning, MSL Made Simple

    2010-01-01

    The new iPad is sleek, powerful, and most importantly, it's much more than just a big iPhone. Your iPad is can be used for reading, surfing the web, emailing, watching TV/Movies, getting work done, and much more. And with the upcoming wave of iPad apps, the possibilities are endless. iPad X Made Simple clarifies all of the key features on the iPad, introduces what's new, and also reveals dozens of time-saving shortcuts and techniques. The book has over 1,000 screen shots that are carefully annotated with step-by-step instructions. * Clear instructions on how to set up and use the iPad * Illust

  9. Simple lattice model of macroevolution

    Science.gov (United States)

    Borkowski, Wojciech

    2009-04-01

    In future astrobiology, like in modern astrophysics, the numerical simulations can be a very important tool for proving theories. In this paper, I propose a simple lattice model of a multi-species ecosystem suitable for the study of emergent properties of macroevolution. Unlike the majority of ecological models, the number of species is not fixed - they emerge by "mutation" of existing species, then survive or go extinct depending on the balance between local ecological interactions. The Monte-Carlo numerical simulations show that this model is able to qualitatively reproduce phenomena that have been empirically observed, like the dependence between size of the isolated area and the number of species inhabiting there, primary production and species-diversity. The model allows also studying the causes of mass extinctions and more generally, repeatability, and the role of pure chance in macroevolution.

  10. Effect of body mass index on clinical and morphological characteristics of triple negative breast cancer

    Directory of Open Access Journals (Sweden)

    I. B. Schepotin

    2014-01-01

    Full Text Available Triple negative breast cancer phenotype characterized by a more aggressive than other molecular types of tumor. In addition to non-modifiable clinical and pathological factors of aggressiveness of triple negative breast cancer is caused by potentially modifiable lifestyle (obesity, alcohol consumption, hypodynamia etc.. In this study we investigated the relationship between body mass index at diagnosis, clinical and morphological outcome predictors, and the impact of obesity on overall and disease-free survival of patients with triple negative breast cancer.

  11. Precipitation regime influence on oxygen triple-isotope distributions in Antarctic precipitation and ice cores

    Science.gov (United States)

    Miller, Martin F.

    2018-01-01

    The relative abundance of 17O in meteoric precipitation is usually reported in terms of the 17O-excess parameter. Variations of 17O-excess in Antarctic precipitation and ice cores have hitherto been attributed to normalised relative humidity changes at the moisture source region, or to the influence of a temperature-dependent supersaturation-controlled kinetic isotope effect during in-cloud ice formation below -20 °C. Neither mechanism, however, satisfactorily explains the large range of 17O-excess values reported from measurements. A different approach, based on the regression characteristics of 103 ln (1 +δ17 O) versus 103 ln (1 +δ18 O), is applied here to previously published isotopic data sets. The analysis indicates that clear-sky precipitation ('diamond dust'), which occurs widely in inland Antarctica, is characterised by an unusual relative abundance of 17O, distinct from that associated with cloud-derived, synoptic snowfall. Furthermore, this distinction appears to be largely preserved in the ice core record. The respective mass contributions to snowfall accumulation - on both temporal and spatial scales - provides the basis of a simple, first-order explanation for the observed oxygen triple-isotope ratio variations in Antarctic precipitation, surface snow and ice cores. Using this approach, it is shown that precipitation during the last major deglaciation, both in western Antarctica at the West Antarctic Ice Sheet (WAIS) Divide and at Vostok on the eastern Antarctic plateau, consisted essentially of diamond dust only, despite a large temperature differential (and thus different water vapour supersaturation conditions) at the two locations. In contrast, synoptic snowfall events dominate the accumulation record throughout the Holocene at both sites.

  12. BRCA1/2-negative hereditary triple-negative breast cancers exhibit BRCAness.

    Science.gov (United States)

    Domagala, Pawel; Hybiak, Jolanta; Cybulski, Cezary; Lubinski, Jan

    2017-04-01

    BRCA1/2-associated breast cancers are sensitive to poly(ADPribose) polymerase (PARP) inhibitors and platinum compounds mainly due to their deficiency in DNA repair via homologous recombination (HR). However, approximately only 15% of triple-negative breast cancers (TNBCs) are BRCA1/2-associated. TNBCs that exhibit BRCAness (a phenotype reflecting impaired HR in BRCA1/2-negative tumors) are also regarded sensitive to PARP inhibitors and platinum compounds. Thus, we hypothesized that hereditary BRCA1/2-negative TNBCs may exhibit BRCAness. To find a subset of hereditary BRCA1/2-negative TNBCs among 360 TNBCs, we first identified a group of 41 hereditary TNBCs by analyzing the family histories of the patients. Next, we tested this group for the presence of germline BRCA1/2 mutations, and finally, we compared the expression levels of 120 genes involved in HR and five other major mechanisms of DNA damage repair between BRCA1/2-associated and BRCA1/2-negative subgroups of hereditary TNBCs using real-time PCR arrays. Approximately 73% of the hereditary TNBCs were BRCA1/2-associated and 27% were BRCA1/2-negative. The expression levels of the analyzed genes showed no significant differences between these two subgroups indicating the BRCAness of the BRCA1/2-negative hereditary TNBCs and thereby distinguishing a novel subset of TNBCs as a potential target for PARP inhibitors or platinum-based therapy. The results show the significance of family history in selecting patients with TNBC for therapies directed at incompetent DNA repair (e.g., PARP inhibitors and/or platinum-based therapies) and indicate that a relatively simple strategy for broadening the target group for these modes of treatment is to identify patients with hereditary TNBCs. © 2016 UICC.

  13. A Simple Demonstration Model of Osmosis

    Science.gov (United States)

    Morse, Joseph G.

    1999-01-01

    A simple device constructed from a wire screen, a large beaker, beans, and oats is described. It provides a simple and effective visual model of the phenomenon of osmosis and, by extension, the origin of other colligative properties of solutions.

  14. Pengaruh Potongan Margin (Muqashah Ar-Ribhi Terhadap Minat nasabah dalam Memanfaatkan Pembiayaan Murabahah di Bank Pembiayaan Rakyat Syariah (BPRS Bhakti Sumekar (Studi Kasus di Kantor Cabang Bluto Sumenep

    Directory of Open Access Journals (Sweden)

    Hotimatul Adalah

    2016-06-01

    Full Text Available PT. BPRS Bhakti Sumekar Branch Bluto Sumenep is one of Bank Syari’ah Financing which functions as an intermediary that has its own the market in distributing financial products, namely the public and small businesses that need capital but in analyzing the customer worthy or not to be given financig by using the ratings analysis 5C to anticipate the risk of financing as doubted, less smooth and credit jammed. This type of research used in this research is quantitative research using using simple linear regression method where the purpose of simple linear regression is to forecast or predict systematically about what is most likely to happen in the future based on the information of the past and present-have for mistakes can be minimized. The data used are primary data obtained through questionnaires. Sample of 73 customers. The instruments used in data collection is by using the questionnaire method, documentation and interviews. While proving the hypothesis using a calculation by the classical assumption test, t test and f test. The results of this research using simple linear regression analysis which states that there is influence between margin pieces (muqashah ar-Ribhi, the equation Y = 19.060 + 0.345 X. Based on the results of testing the hypothesis with t test and F test shows significant value where t count> t table = 6.784 0.000 ˃1.666 with significant level of 0,000 less than 0.05. And the F test showed the value of Fcount ˃ Ftabel (46.027 ˃ 3.98 with the level of sig. Of as big as 0000. It can be concluded that simultaneously margin pieces (muqashah ar-Ribhi has a significant effect on the customers' interest in utilizing financing murabaha at Bank Financing Shari’ah People (BPRS Bhakti Sumekar (Case Study at the Branch Office Bluto Sumenep.

  15. Risk Factors for Triple-Negative Breast Cancer in Women Under the Age of 45 Years

    National Research Council Canada - National Science Library

    Jessica M. Dolle; Janet R. Daling; Emily White; Louise A. Brinton; David R. Doody; Peggy L. Porter; Kathleen E. Malone

    2009-01-01

    .... We undertook this study to assess the risk for triple-negative breast cancer among women 45 years of age and younger in relation to demographic/lifestyle factors, reproductive history, and oral contraceptive use...

  16. The Safety Profile of Telaprevir-Based Triple Therapy in Clinical Practice: A Retrospective Cohort Study

    National Research Council Canada - National Science Library

    Iketani, Ryo; Ide, Kazuki; Yamada, Hiroshi; Kawasaki, Yohei; Masaki, Naohiko

    2017-01-01

    .... This retrospective cohort study compared telaprevir-based triple therapy (T/PR) with PR therapy. The study population comprised patients with genotype 1 chronic hepatitis C represented in the database between December 2009 and August 2015...

  17. Surgical experience of laparoscopic retroperitoneal triple neurectomy for a patient with chronic neuropathic inguinodynia

    Directory of Open Access Journals (Sweden)

    Masato Narita

    2017-01-01

    Conclusions: Laparoscopic retroperitoneal triple neurectomy is useful for treating refractory neuropathic pain. The diagnosis of neuropathic pain via thorough preoperative assessment is vital for procedure success because the procedure would not be effective for other types of pain.

  18. The multisection method for triple products and identities of Rogers-Ramanujan type

    Science.gov (United States)

    Chu, Wenchang; Wang, Chenying

    2008-03-01

    By applying the bisection and trisection method to Jacobi's triple product identity, we establish several identities factorizing sum and difference of infinite products, which lead, in turn, to new and elementary proofs for twenty identities of Rogers-Ramanujan type.

  19. Revisiting Triple Antibiotic Irrigation of Breast Implant Pockets: A Placebo-controlled Single Practice Cohort Study

    Directory of Open Access Journals (Sweden)

    James J. Drinane, BSci

    2013-10-01

    Conclusions: Triple antibiotic breast irrigation is not associated with a significant reduction in the incidence or severity of capsular contracture compared with sterile saline when high-quality surgical technique is used.

  20. Toxic Anterior Segment Syndrome following a Triple Descemet’s Stripping Automated Endothelial Keratoplasty Procedure

    Directory of Open Access Journals (Sweden)

    Nir Sorkin

    2012-11-01

    Full Text Available Purpose: To present a unique case of a 58-year-old female with toxic anterior segment syndrome (TASS, following a triple procedure: Descemet’s stripping automated endothelial keratoplasty (DSAEK, phacoemulsification and posterior chamber intraocular lens implantation. Methods: The patient was treated with topical dexamethasone sodium phosphate 0.1% and topical atropine sulfate 1%. Due to a slow improvement in her clinical status, oral prednisone 1 mg/kg/day was added. Results: The anterior chamber reaction improved gradually, with tapering down of topical and oral treatment, until a complete resolution of the anterior chamber reaction was observed. Conclusions: Taking into account the estimated volume of DSAEK triple procedures performed worldwide, we would expect an annual incidence of several TASS cases, following triple DSAEK procedures. However, we were unable to find any such previous reports in the literature. This fact raises questions regarding the cause of reduced TASS incidence following triple DSAEK procedures.

  1. Simple substrates for complex cognition

    Directory of Open Access Journals (Sweden)

    Peter Dayan

    2008-12-01

    Full Text Available Complex cognitive tasks present a range of computational and algorithmic challenges for neural accounts of both learning and inference. In particular, it is extremely hard to solve them using the sort of simple policies that have been extensively studied as solutions to elementary Markov decision problems. There has thus been recent interest in architectures for the instantiation and even learning of policies that are formally more complicated than these, involving operations such as gated working memory. However, the focus of these ideas and methods has largely been on what might best be considered as automatized, routine or, in the sense of animal conditioning, habitual, performance. Thus, they have yet to provide a route towards understanding the workings of rule-based control, which is critical for cognitively sophisticated competence. Here, we review a recent suggestion for a uniform architecture for habitual and rule-based execution, discuss some of the habitual mechanisms that underpin the use of rules, and consider a statistical relationship between rules and habits.

  2. Semiregular factorization of simple graphs

    Directory of Open Access Journals (Sweden)

    Anthony J. Hilton

    2004-11-01

    Full Text Available A graph G is a (d, d + s-graph if the degree of each vertex of G lies in the interval [d, d + s]. A (d, d + 1-graph is said to be semiregular. An (r, r + 1 -factorization of a graph is a decomposition of the graph into edgedisjoint (r, r + 1-factors.We discuss here the state of knowledge about (r, r + 1-factorizations of d -regular graphs and of (d, d + 1-graphs.For r, s ≥ 0, let φ(r, s be the least integer such that, if d ≥ φ(r, s and G is any simple [d, d + s]-graph, then G has an (r, r + 1-factorization.Akiyama and Kano (when r is even and Cai (when r is odd showed that φ(r, s exists for all r, s. We show that, for s ≥ 2, φ(r, s = r(r + s + 1 + 1. Earlier φ(r, 0 was determined by Egawa and Era, and φ(r, 1 was determined by Hilton.

  3. Simple Quantum Dynamics with Thermalization.

    Science.gov (United States)

    Jansen, Thomas L C

    2018-01-11

    In this paper, we introduce two simple quantum dynamics methods. One is based on the popular surface-hopping method, and the other is based on rescaling of the propagation on the bath ground-state potential surface. The first method is special, as it avoids specific feedback from the simulated quantum system to the bath and can be applied for precalculated classical trajectories. It is based on the equipartition theorem to determine if hops between different potential energy surfaces are allowed. By comparing with the formally exact Hierarchical Equations Of Motion approach for four model systems we find that the method generally approximates the quantum dynamics toward thermal equilibrium very well. The second method is based on rescaling of the nonadiabatic coupling and also neglect the effect of the state of the quantum system on the bath. By the nature of the approximations, they cannot reproduce the effect of bath relaxation following excitation. However, the methods are both computationally more tractable than the conventional fewest switches surface hopping, and we foresee that the methods will be powerful for simulations of quantum dynamics in systems with complex bath dynamics, where the system-bath coupling is not too strong compared to the thermal energy.

  4. Simple model for molecular scattering

    Science.gov (United States)

    Mehta, Nirav; Ticknor, Christopher; Hazzard, Kaden

    2017-04-01

    The collisions of ultracold molecules are qualitatively different from the collisions of ultracold atoms due to the high density of bimolecular resonances near the collision energy. We present results from a simple N-channel scattering model with square-well channel potentials and constant channel couplings (inside the well) designed to reproduce essential features of chaotic molecular scattering. The potential depths and channel splittings are tuned to reproduce the appropriate density of states for the short-range bimolecular collision complex (BCC), which affords a direct comparison of the resulting level-spacing distribution to that expected from random matrix theory (RMT), namely the so-called Wigner surmise. The density of states also sets the scale for the rate of dissociation from the BCC to free molecules, as approximated by transition state theory (TST). Our model affords a semi-analytic solution for the scattering amplitude in the open channel, and a determinantal equation for the eigenenergies of the short-ranged BCC. It is likely the simplest finite-ranged scattering model that can be compared to expectations from the approximations of RMT, and TST. The validity of these approximations has implications for the many-channel Hubbard model recently developed. This research was funded in part by the National Science Foundation under Grant No. NSF PHY-1125915.

  5. Triple Modular Redundancy verification via heuristic netlist analysis

    Directory of Open Access Journals (Sweden)

    Giovanni Beltrame

    2015-08-01

    Full Text Available Triple Modular Redundancy (TMR is a common technique to protect memory elements for digital processing systems subject to radiation effects (such as in space, high-altitude, or near nuclear sources. This paper presents an approach to verify the correct implementation of TMR for the memory elements of a given netlist (i.e., a digital circuit specification using heuristic analysis. The purpose is detecting any issues that might incur during the use of automatic tools for TMR insertion, optimization, place and route, etc. Our analysis does not require a testbench and can perform full, exhaustive coverage within less than an hour even for large designs. This is achieved by applying a divide et impera approach, splitting the circuit into smaller submodules without loss of generality, instead of applying formal verification to the whole netlist at once. The methodology has been applied to a production netlist of the LEON2-FT processor that had reported errors during radiation testing, successfully showing a number of unprotected memory elements, namely 351 flip-flops.

  6. Strongly Misaligned Triple System in SR 24 Revealed by ALMA

    Science.gov (United States)

    Fernández-López, M.; Zapata, L. A.; Gabbasov, R.

    2017-08-01

    We report the detection of the 1.3 mm continuum and the molecular emission of the disks of the young triple system SR24 by analyzing ALMA (The Atacama Large Millimeter/Submillimter Array) subarcsecond archival observations. We estimate the mass of the disks (0.025 M ⊙ and 4 × 10-5 M ⊕ for SR24S and SR24N, respectively) and the dynamical mass of the protostars (1.5 M ⊙ and 1.1 M ⊙). A kinematic model of the SR24S disk to fit its C18O (2-1) emission allows us to develop an observational method to determine the tilt of a rotating and accreting disk. We derive the size, inclination, position angle, and sense of rotation of each disk, finding that they are strongly misaligned (108^\\circ ) and possibly rotate in opposite directions as seen from Earth, in projection. We compare the ALMA observations with 12CO SMA archival observations, which are more sensitive to extended structures. We find three extended structures and estimate their masses: a molecular bridge joining the disks of the system, a molecular gas reservoir associated with SR24N, and a gas streamer associated with SR24S. Finally, we discuss the possible origin of the misaligned SR24 system, concluding that a closer inspection of the northern gas reservoir is needed to better understand it.

  7. Simultaneous phacoemulsification, lens implantation and endothelial keratoplasty: Triple procedure

    Directory of Open Access Journals (Sweden)

    Nikolić Ljubiša

    2011-01-01

    Full Text Available Introduction. Simultaneous Descemet stripping endothelial keratoplasty, phacoemulsification, and intraocular lens implantation are indicated in Fuchs’ dystrophy with associated cataract. Compared to the standard method of the triple procedure which includes penetrating keratoplasty, this new method has the advantages of sutureless surgery, small limbal incision, faster recovery, less surface problems, less astigmatism, stronger tensile strength and more predictable calculation of the intraocular lens power. This is the first report of such a combination of procedures in our literature. Case report. A 76-year-old woman suffered from a gradual bilateral visual loss. The best corrected visual acuity was 20/60 (right eye and finger counting at 1m (left eye. Corneal thickness was 590 μm and 603 μm, respectively. A marked cornea guttata and nuclear cataract were present in both eyes. Phacoemulsification, lens implantation, and Descemet stripping were done in the left eye. The posterior lamellar corneal graft, 8.0 mm in diameter and about 150 μm thick, was bent and inserted through the limbal incision. The air was injected into the anterior chamber to attach the graft to the recipient stroma. The cornea remained clear, and the transplant was attached during a two-year follow-up. Visual acuity was 20/40 after two months, and 20/25 after one year. Conclusion. The new technique proved itself as a good choice for the treatment of a mild Fuchs’ dystrophy associated with cataract.

  8. Triple Bioluminescence Imaging for In Vivo Monitoring of Cellular Processes

    Directory of Open Access Journals (Sweden)

    Casey A Maguire

    2013-01-01

    Full Text Available Bioluminescence imaging (BLI has shown to be crucial for monitoring in vivo biological processes. So far, only dual bioluminescence imaging using firefly (Fluc and Renilla or Gaussia (Gluc luciferase has been achieved due to the lack of availability of other efficiently expressed luciferases using different substrates. Here, we characterized a codon-optimized luciferase from Vargula hilgendorfii (Vluc as a reporter for mammalian gene expression. We showed that Vluc can be multiplexed with Gluc and Fluc for sequential imaging of three distinct cellular phenomena in the same biological system using vargulin, coelenterazine, and D-luciferin substrates, respectively. We applied this triple imaging system to monitor the effect of soluble tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL delivered using an adeno-associated viral vector (AAV on brain tumors in mice. Vluc imaging showed efficient sTRAIL gene delivery to the brain, while Fluc imaging revealed a robust antiglioma therapy. Further, nuclear factor-κB (NF-κB activation in response to sTRAIL binding to glioma cells death receptors was monitored by Gluc imaging. This work is the first demonstration of trimodal in vivo bioluminescence imaging and will have a broad applicability in many different fields including immunology, oncology, virology, and neuroscience.

  9. Phoebe 2.0 - Triple and multiple systems

    Science.gov (United States)

    Conroy, K.; Degroote, P.; Hambleton, K.; Bloemen, S.; Pablo, H.; Giammarco, J.; Prša, A.

    2013-02-01

    Some close binary formation theories require the presence of a third body so that the binary orbit can shrink over time. Tidal friction and Kozai cycles transfer energy from the binary to its companion, resulting in a close inner binary and a wide third body orbit. Spectroscopy and imaging studies have found 40% of binaries with periods less than 10 days, and 96% with periods less than 3 days, have a wide tertiary companion. With recent advancements in large photometric surveys, we are now beginning to detect many of these triple systems by observing tertiary eclipses or through the effect they have on the eclipse timing variations (ETVs) of the inner-binary. In the sample of 2600 Kepler EBs, we have detected the possible presence of a third body in ˜20%, including several circumbinary planets. Some multiple systems are quite dynamical and feature disappearing and reappearing eclipses, apsidal motion, and large disruptions to the inner-binary. phoebe is a freely available binary modeling code which can dynamically model all of these systems, allowing us to better test formation theories and probe the physics of eclipsing binaries.

  10. W mass and Triple Gauge Couplings at Tevatron

    Directory of Open Access Journals (Sweden)

    Pétroff Pierre

    2013-05-01

    Full Text Available The W mass is a crucial parameter in the Standard Model (SM of particle physics, providing constraints on the mass of the Higgs boson as well as on new physics models via quantum loop corrections. On the other hand, any deviation of the triple gauge boson couplings (TGC from their values predicted by the SM would be also an indication for new physics. We present recent measurements on W boson mass and searches for anomalous TGC (aTGC in Wγ, Zγ, WW, WZ and ZZ at Fermilab Tevatron both by CDF and DØ Collaborations. The CDF Collaboration has measured the W boson mass using data corresponding to 2.2 fb−1 of integrated luminosity. The measurement, performed using electron and muon decays of W boson, yields a mass of MW = 80387 ± 19 MeV. The DØ Collaboration has measured MW = 80367 ± 26 MeV with data corresponding to 4.3 fb−1 of integrated luminosity in the channel W → ev. The combination with an earlier DØ result, using independant data sample at 1 fb−1 of integrated luminosity, yields MW = 80375 ± 23 MeV. The limits on anomalous TGCs parameters are consistent with the SM expectations.

  11. Performance of a Horizontal Triple Cylinder Type Pulping Machine

    Directory of Open Access Journals (Sweden)

    Sukrisno Widyotomo

    2011-05-01

    Full Text Available Pulping is one important step in wet coffee processing method. Pulping process usually uses a machine which constructed by wood or metal materials. A horizontal single cylinder type of fresh coffee cherries pulping machine is the most popular machine in coffee processing. One of the weaknesses of a horizontal single cylinder type of fresh coffee cherries pulping machine is higher in broken beans. Broken bean is one of mayor aspects in defect system that contribute to low quality. Indonesian Coffee and Cocoa Research Institute has designed and tested a horizontal double cylinder type of fresh coffee cherries pulping machine which resulted in 12.6—21.4% of broken beans. To reduce percentage of broken beans, Indonesian Coffee and Cocoa Research Institute has developed and tested a horizontal triple cylinder type of fresh coffee cherries pulping machine. Material tested was fresh mature Robusta coffee cherries, 60—65% (wet basis moisture content; has classified on 3 levels i.e. unsorted, small and medium, and clean from metal and foreign materials. The result showed that the machine produced 6,340 kg/h in optimal capacity for operational conditions, 1400 rpm rotor rotation speed for unsorted coffee cherries with composition 55.5% whole parchment coffee, 3.66% broken beans, and 1% beans in wet skin.Key words : coffee, pulp, pulper, cylinder, quality.

  12. Comparing Relational and Ontological Triple Stores in Healthcare Domain

    Directory of Open Access Journals (Sweden)

    Ozgu Can

    2017-01-01

    Full Text Available Today’s technological improvements have made ubiquitous healthcare systems that converge into smart healthcare applications in order to solve patients’ problems, to communicate effectively with patients, and to improve healthcare service quality. The first step of building a smart healthcare information system is representing the healthcare data as connected, reachable, and sharable. In order to achieve this representation, ontologies are used to describe the healthcare data. Combining ontological healthcare data with the used and obtained data can be maintained by storing the entire health domain data inside big data stores that support both relational and graph-based ontological data. There are several big data stores and different types of big data sets in the healthcare domain. The goal of this paper is to determine the most applicable ontology data store for storing the big healthcare data. For this purpose, AllegroGraph and Oracle 12c data stores are compared based on their infrastructural capacity, loading time, and query response times. Hence, healthcare ontologies (GENE Ontology, Gene Expression Ontology (GEXO, Regulation of Transcription Ontology (RETO, Regulation of Gene Expression Ontology (REXO are used to measure the ontology loading time. Thereafter, various queries are constructed and executed for GENE ontology in order to measure the capacity and query response times for the performance comparison between AllegroGraph and Oracle 12c triple stores.

  13. Triple Halo Coil: Development and Comparison with Other TMS Coils

    Science.gov (United States)

    Rastogi, Priyam; Hadimani, Ravi; Jiles, David

    Transcranial Magnetic Stimulation (TMS) is a non-invasive stimulation technique that can be used for the treatment of various neurological disorders such as Parkinson's Disease, PTSD, TBI and anxiety by regulating synaptic activity. TMS is FDA approved for the treatment of major depressive disorder. There is a critical need to develop deep TMS coils that can stimulate deeper regions of the brain without excessively stimulating the cortex in order to provide an alternative to surgical methods. We have developed a novel multi-coil configuration called ``Triple Halo Coil'' (THC) that can stimulate deep brain regions. Investigation of induced electric and magnetic field in these regions have been achieved by computer modelling. Comparison of the results due to THC configuration have been conducted with other TMS coils such as ``Halo Coil'', circular coil and ``Figure of Eight'' coil. There was an improvement of more than 15 times in the strength of magnetic field, induced by THC configuration at 10 cm below the vertex of the head when compared with the ``Figure of Eight'' coil alone. Carver Charitable Trust.

  14. Triple diagnostics for early detection of ambivalent necrotizing fasciitis.

    Science.gov (United States)

    Hietbrink, Falco; Bode, Lonneke G; Riddez, Louis; Leenen, Luke P H; van Dijk, Marijke R

    2016-01-01

    Necrotizing fasciitis is an uncommon, rapidly progressive and potential lethal condition. Over the last decade time to surgery decreased and outcome improved, most likely due to increased awareness and more timely referral. Early recognition is key to improve mortality and morbidity. However, early referral frequently makes it a challenge to recognize this heterogeneous disease in its initial stages. Signs and symptoms might be misleading or absent, while the most prominent skin marks might be in discrepancy with the position of the fascial necrosis. Gram staining and especially fresh frozen section histology might be a useful adjunct. Retrospective analysis of 3 year period. Non-transferred patients who presented with suspected necrotizing fasciitis are included. ASA classification was determined. Mortality was documented. In total, 21 patients are included. Most patients suffered from severe comorbidities. In 11 patients, diagnoses was confirmed based on intra-operative macroscopic findings. Histology and/or microbiotic findings resulted in 6/10 remaining patients in a change in treatment strategy. In total, 17 patients proved to suffer necrotizing fasciitis. In the cohort series 2 patients died due to necrotizing fasciitis. In the early phases of necrotizing fasciitis, clinical presentation can be ambivalent. In the present cohort, triple diagnostics consisting of an incisional biopsy with macroscopic, histologic and microbiotic findings was helpful in timely identification of necrotizing fasciitis.

  15. Rad51 supports triple negative breast cancer metastasis

    Science.gov (United States)

    Wiegmans, Adrian P; Al-Ejeh, Fares; Chee, Nicole; Yap, Pei-Yi; Gorski, Julia J; Silva, Leonard Da; Bolderson, Emma; Chenevix-Trench, Georgia; Anderson, Robin; Simpson, Peter T; Lakhani, Sunil R; Khanna, Kum Kum

    2014-01-01

    In contrast to extensive studies on familial breast cancer, it is currently unclear whether defects in DNA double strand break (DSB) repair genes play a role in sporadic breast cancer development and progression. We performed analysis of immunohistochemistry in an independent cohort of 235 were sporadic breast tumours. This analysis suggested that RAD51 expression is increased during breast cancer progression and metastasis and an oncogenic role for RAD51 when deregulated. Subsequent knockdown of RAD51 repressed cancer cell migration in vitro and reduced primary tumor growth in a syngeneic mouse model in vivo. Loss of RAD51 also inhibited associated metastasis not only in syngeneic mice but human xenografts and changed the metastatic gene expression profile of cancer cells, consistent with inhibition of distant metastasis. This demonstrates for the first time a new function of RAD51 that may underlie the proclivity of patients with RAD51 overexpression to develop distant metastasis. RAD51 is a potential biomarker and attractive drug target for metastatic triple negative breast cancer, with the capability to extend the survival of patients, which is less than 6 months. PMID:24811120

  16. MCNP analysis and optimization of a triple crystal phoswich detector

    CERN Document Server

    Childress, N L

    2002-01-01

    Researchers at the University of Missouri-Columbia have designed a triple crystal phoswich detector that allows for simultaneous detection of alpha, beta, and gamma radiation. A ZnS:Ag layer detects alpha particles, a CaF sub 2 :Eu scintillator preferentially interacts with beta particles, and a NaI:Tl cell is used for gamma detection. The detector output is digitally collected, processed, and analyzed by a personal computer using custom software. Monte Carlo N-Particle version 4C simulations of this detector found that the phoswich design has inherent minimum energy limits of 250 keV E sub m sub a sub x for beta particles and 50 keV for gamma-rays. For a 2.54 cm thick NaI:Tl crystal, intrinsic gamma efficiency for photons ranges from a maximum of 80% at 100 keV to 26% for 2 MeV photons. Mischaracterized gamma events in the CaF sub 2 :Eu crystal above 175 keV can be corrected by subtracting 26+-4% of the total number of counts in the NaI:Tl crystal from the CaF sub 2 :Eu response. Beta induced events in the N...

  17. Clinical Characteristics in Patients with Triple Negative Breast Cancer

    Directory of Open Access Journals (Sweden)

    Janet Yeh

    2017-01-01

    Full Text Available Purpose. The purpose of this study was to compare and contrast the clinical characteristics of the triple negative breast cancer (TNBC and non-TNBC patients, with a particular focus on genetic susceptibility and risk factors prior to diagnosis. Methods. Our institutional database was queried for all patients diagnosed with invasive breast cancer between January 2010 and May 2016. Results. Out of a total of 1964 patients, 190 (10% patients had TNBC. The median age for both TNBC and non-TNBC was 59 years. There was a significantly higher proportion of African American and Asian patients with TNBC (p=0.0003 compared to patients with non-TNBC. BRCA1 and BRCA2 were significantly associated with TNBC (p<0.0001, p=0.0007. A prior history of breast cancer was significantly associated with TNBC (p=0.0003. There was no relationship observed between TNBC and a history of chemoprevention or patients who had a history of AH or LCIS. Conclusions. We found that having Asian ancestry, a prior history of breast cancer, and a BRCA1 or BRCA2 mutation all appear to be positively associated with TNBC. In order to develop more effective treatments, better surveillance, and improved prevention strategies, it is necessary to improve our understanding of the population at risk for TNBC.

  18. Optimization of the triple-pressure combined cycle power plant

    Directory of Open Access Journals (Sweden)

    Alus Muammer

    2012-01-01

    Full Text Available The aim of this work was to develop a new system for optimization of parameters for combined cycle power plants (CCGTs with triple-pressure heat recovery steam generator (HRSG. Thermodynamic and thermoeconomic optimizations were carried out. The objective of the thermodynamic optimization is to enhance the efficiency of the CCGTs and to maximize the power production in the steam cycle (steam turbine gross power. Improvement of the efficiency of the CCGT plants is achieved through optimization of the operating parameters: temperature difference between the gas and steam (pinch point P.P. and the steam pressure in the HRSG. The objective of the thermoeconomic optimization is to minimize the production costs per unit of the generated electricity. Defining the optimal P.P. was the first step in the optimization procedure. Then, through the developed optimization process, other optimal operating parameters (steam pressure and condenser pressure were identified. The developed system was demonstrated for the case of a 282 MW CCGT power plant with a typical design for commercial combined cycle power plants. The optimized combined cycle was compared with the regular CCGT plant.

  19. Comparison of triple antibiotic paste removal by different irrigation techniques.

    Science.gov (United States)

    Aksel, Hacer; Küçükkaya Eren, Selen; Serper, Ahmet

    2017-05-31

    This study compared different irrigation techniques in triple antibiotic paste (TAP) removal from root canals. Fifty-six maxillaryanterior-teeth were filled with TAP for 28 days, and assigned into 5 experimental groups (n=10): Syringe irrigation (SI), NaviTip FX (NFX), Vibringe-Syringe irrigation (V-SI), NaviTip FX-Vibringe (V-NFX), passive ultrasonic irrigation (PUI) and positive and negative control groups (n=3 for each). Following the removal of the medicament, the remaining medicament was evaluated using 4-grade scoring-system. V-NFX and NFX showed similar performances (p>0.05) while V-NFX was significantly more efficient than SI and PUI (p0.05). Regarding different parts of the root canals, V-SI and PUI were significantly less efficient at the apical part (pirrigation delivery with and without sonic activation improved the removal of TAP from the root canals when compared to ultrasonic activation, syringe irrigation or sonic activation alone.

  20. Mometasone-based triple combination therapy in melasma: is it really safe?

    Science.gov (United States)

    Majid, Imran

    2010-10-01

    Kligman's triple combination formula has been one of the most popular treatment options in melasma over the last three decades. The original Kligman's formula has been modified in many ways over the years and the most recent modification that has been introduced is a triple combination of 2% hydroquinone, 0.025% tretinoin, and 1% mometasone. The use of this triple combination in patients with melasma has seen a sharp rise over the last few years and with this rampant use the side-effect profile of this triple combination has also come to the fore. The aim of the present study was to assess the overall safety of the mometasone-based triple combination treatment in the management of melasma. This retrospective study was performed on 60 patients of melasma who had used a mometasone-based triple combination treatment for at least 3 weeks anytime in the previous 1 year. The patients were given a preformed questionnaire wherein they assessed the overall effect of the triple combination treatment on their melasma during its use as well as after its withdrawal. The patients were specifically asked about the status of their disease as well as the sun sensitivity of their skin before and after the use of triple combination treatment. In addition, the patients were assessed by a single trained dermatologist for the presence of any adverse effects arising out of the triple combination treatment in the form of telangiectasia, hypertrichosis, acne, skin atrophy, etc. Majority of patients (51.7%) had used the combination treatment well beyond the recommended duration. About one-third (36.7%) of the patients rated their melasma as worse at the time of filling the questionnaire as compared with their disease before the use of triple combination treatment. On clinical examination, the evidence of steroid side effects was seen in 26 patients (43.3%). Steroid-induced telangiectasia was the commonest finding, seen in all of these 26 patients. Steroid-induced skin atrophy

  1. Mometasone-based triple combination therapy in melasma: Is it really safe?

    Directory of Open Access Journals (Sweden)

    Majid Imran

    2010-01-01

    Full Text Available Background: Kligman′s triple combination formula has been one of the most popular treatment options in melasma over the last three decades. The original Kligman′s formula has been modified in many ways over the years and the most recent modification that has been introduced is a triple combination of 2% hydroquinone, 0.025% tretinoin, and 1% mometasone. The use of this triple combination in patients with melasma has seen a sharp rise over the last few years and with this rampant use the side-effect profile of this triple combination has also come to the fore. Aim : The aim of the present study was to assess the overall safety of the mometasone-based triple combination treatment in the management of melasma. Materials and Methods: This retrospective study was performed on 60 patients of melasma who had used a mometasone-based triple combination treatment for at least 3 weeks anytime in the previous 1 year. The patients were given a preformed questionnaire wherein they assessed the overall effect of the triple combination treatment on their melasma during its use as well as after its withdrawal. The patients were specifically asked about the status of their disease as well as the sun sensitivity of their skin before and after the use of triple combination treatment. In addition, the patients were assessed by a single trained dermatologist for the presence of any adverse effects arising out of the triple combination treatment in the form of telangiectasia, hypertrichosis, acne, skin atrophy, etc. Results: Majority of patients (51.7% had used the combination treatment well beyond the recommended duration. About one-third (36.7% of the patients rated their melasma as worse at the time of filling the questionnaire as compared with their disease before the use of triple combination treatment. On clinical examination, the evidence of steroid side effects was seen in 26 patients (43.3%. Steroid-induced telangiectasia was the commonest finding, seen

  2. Triple constraint considerations in the management of construction projects : a South African perspective

    OpenAIRE

    2013-01-01

    M.Ing. (Engineering Management) The triple constraint considerations in construction projects determine failure or success of projects. The key reasons of a winning project comprise of identification, monitoring, control and management of projects risks. Projects, over the years, failed to be completed within the contracted triple constraints. The persistent failure of construction projects in South Africa contributes to lack of development in skills and infrastructure. It is hypothesized ...

  3. Triple-Stranded Cluster Helicates for the Selective Catalytic Oxidation of C-H Bonds.

    Science.gov (United States)

    Fang, Yu; Gong, Wei; Liu, Lujia; Liu, Yan; Cui, Yong

    2016-10-17

    Triple-stranded cluster helicates with heptametallic dicubane cores are synthesized by entrapping metals in the cavities of linear triple helicates based on a C2-symmetrical hexadentate Schiff-base ligand of ortho-substitued biphenol. The helicates are stable in both the solution and solid states, and the copper species could selectively catalyze the oxidation of C-H bonds of alkanes to ketones.

  4. SDSS J1056+5516: A Triple AGN or an SMBH Recoil Candidate?

    Science.gov (United States)

    Kalfountzou, E.; Santos Lleo, M.; Trichas, M.

    2017-12-01

    We report the discovery of a kiloparsec-scale triple supermassive black hole system at z = 0.256: SDSS J1056+5516, discovered by our systematic search for binary quasars. The system contains three strong emission-line nuclei, which are offset by black hole (SMBH) interacting system, a triple AGN, or a recoiling SMBH. Each of these scenarios is unique for our understanding of the hierarchical growth of galaxies, AGN triggering, and gravitational waves.

  5. Measurement of triple gauge-boson couplings at 172 GeV

    CERN Document Server

    Barate, R; Décamp, D; Ghez, P; Goy, C; Lees, J P; Lucotte, A; Minard, M N; Nief, J Y; Pietrzyk, B; Boix, G; Casado, M P; Chmeissani, M; Crespo, J M; Delfino, M C; Fernández, E; Fernández-Bosman, M; Garrido, L; Graugès-Pous, E; Juste, A; Martínez, M; Merino, G; Miquel, R; Mir, L M; Morawitz, P; Park, I C; Pascual, A; Perlas, J A; Riu, I; Sánchez, F; Colaleo, A; Creanza, D; De Palma, M; Gelao, G; Iaselli, Giuseppe; Maggi, G; Maggi, M; Nuzzo, S; Ranieri, A; Raso, G; Ruggieri, F; Selvaggi, G; Silvestris, L; Tempesta, P; Tricomi, A; Zito, G; Huang, X; Lin, J; Ouyang, Q; Wang, T; Xie, Y; Xu, R; Xue, S; Zhang, J; Zhang, L; Zhao, W; Abbaneo, D; Alemany, R; Becker, U; Bright-Thomas, P G; Casper, David William; Cattaneo, M; Cerutti, F; Ciulli, V; Dissertori, G; Drevermann, H; Forty, Roger W; Frank, M; Gianotti, F; Hagelberg, R; Hansen, J B; Harvey, J; Janot, P; Jost, B; Lehraus, Ivan; Mato, P; Minten, Adolf G; Moneta, L; Pacheco, A; Pusztaszeri, J F; Ranjard, F; Rolandi, Luigi; Rousseau, D; Schlatter, W D; Schmitt, M; Schneider, O; Tejessy, W; Teubert, F; Tomalin, I R; Vreeswijk, M; Wachsmuth, H W; Wagner, A; Ajaltouni, Ziad J; Badaud, F; Chazelle, G; Deschamps, O; Falvard, A; Ferdi, C; Gay, P; Guicheney, C; Henrard, P; Jousset, J; Michel, B; Monteil, S; Montret, J C; Pallin, D; Perret, P; Podlyski, F; Proriol, J; Rosnet, P; Fearnley, Tom; Hansen, J D; Hansen, J R; Hansen, P H; Nilsson, B S; Rensch, B; Wäänänen, A; Daskalakis, G; Kyriakis, A; Markou, C; Simopoulou, Errietta; Vayaki, Anna; Blondel, A; Brient, J C; Machefert, F P; Rougé, A; Rumpf, M; Valassi, Andrea; Videau, H L; Boccali, T; Focardi, E; Parrini, G; Zachariadou, K; Cavanaugh, R J; Corden, M; Georgiopoulos, C H; Hühn, T; Jaffe, D E; Antonelli, A; Bencivenni, G; Bologna, G; Bossi, F; Campana, P; Capon, G; Chiarella, V; Felici, G; Laurelli, P; Mannocchi, G; Murtas, F; Murtas, G P; Passalacqua, L; Pepé-Altarelli, M; Curtis, L; Dorris, S J; Halley, A W; Lynch, J G; Negus, P; O'Shea, V; Raine, C; Scarr, J M; Smith, K; Teixeira-Dias, P; Thompson, A S; Thomson, E; Thomson, F; Ward, J J; Buchmüller, O L; Dhamotharan, S; Geweniger, C; Graefe, G; Hanke, P; Hansper, G; Hepp, V; Kluge, E E; Putzer, A; Sommer, J; Tittel, K; Werner, S; Wunsch, M; Beuselinck, R; Binnie, David M; Cameron, W; Dornan, Peter J; Girone, M; Goodsir, S M; Martin, E B; Marinelli, N; Moutoussi, A; Nash, J; Sedgbeer, J K; Spagnolo, P; Williams, M D; Ghete, V M; Girtler, P; Kneringer, E; Kuhn, D; Rudolph, G; Betteridge, A P; Bowdery, C K; Buck, P G; Colrain, P; Crawford, G; Finch, A J; Foster, F; Hughes, G; Jones, R W L; Whelan, E P; Williams, M I; Giehl, I; Hoffmann, C; Jakobs, K; Kleinknecht, K; Quast, G; Renk, B; Rohne, E; Sander, H G; Van Gemmeren, P; Zeitnitz, C; Aubert, Jean-Jacques; Benchouk, C; Bonissent, A; Bujosa, G; Carr, J; Coyle, P; Ealet, A; Fouchez, D; Leroy, O; Motsch, F; Payre, P; Talby, M; Sadouki, A; Thulasidas, M; Tilquin, A; Trabelsi, K; Aleppo, M; Antonelli, M; Ragusa, F; Berlich, R; Blum, Walter; Büscher, V; Dietl, H; Ganis, G; Gotzhein, C; Kroha, H; Lütjens, G; Lutz, Gerhard; Mannert, C; Männer, W; Moser, H G; Richter, R H; Rosado-Schlosser, A; Schael, S; Settles, Ronald; Seywerd, H C J; Stenzel, H; Wiedenmann, W; Wolf, G; Boucrot, J; Callot, O; Chen, S; Davier, M; Duflot, L; Grivaz, J F; Heusse, P; Höcker, A; Jacholkowska, A; Kado, M; Kim, D W; Le Diberder, F R; Lefrançois, J; Lutz, A M; Schune, M H; Serin, L; Tournefier, E; Veillet, J J; Videau, I; Zerwas, D; Azzurri, P; Bagliesi, G; Bettarini, S; Bozzi, C; Calderini, G; Dell'Orso, R; Fantechi, R; Ferrante, I; Giassi, A; Gregorio, A; Ligabue, F; Lusiani, A; Marrocchesi, P S; Messineo, A; Palla, Fabrizio; Rizzo, G; Sanguinetti, G; Sciabà, A; Sguazzoni, G; Steinberger, Jack; Tenchini, Roberto; Vannini, C; Venturi, A; Verdini, P G; Blair, G A; Bryant, L M; Chambers, J T; Coles, J; Green, M G; Medcalf, T; Perrodo, P; Strong, J A; Von Wimmersperg-Töller, J H; Botterill, David R; Clifft, R W; Edgecock, T R; Haywood, S; Maley, P; Norton, P R; Thompson, J C; Wright, A E; Bloch-Devaux, B; Colas, P; Fabbro, B; Faïf, G; Lançon, E; Lemaire, M C; Locci, E; Pérez, P; Przysiezniak, H; Rander, J; Renardy, J F; Rosowsky, A; Roussarie, A; Trabelsi, A; Vallage, B; Black, S N; Dann, J H; Kim, H Y; Konstantinidis, N P; Litke, A M; McNeil, M A; Taylor, G; Booth, C N; Brew, C A J; Cartwright, S L; Combley, F; Kelly, M S; Lehto, M H; Reeve, J; Thompson, L F; Affholderbach, K; Böhrer, A; Brandt, S; Cowan, G D; Foss, J; Grupen, Claus; Smolik, L; Stephan, F; Apollonio, M; Bosisio, L; Della Marina, R; Giannini, G; Gobbo, B; Musolino, G; Pütz, J; Rothberg, J E; Wasserbaech, S R; Williams, R W; Armstrong, S R; Charles, E; Elmer, P; Ferguson, D P S; Gao, Y; González, S; Greening, T C; Hayes, O J; Hu, H; Jin, S; McNamara, P A; Nachtman, J M; Nielsen, J; Orejudos, W; Pan, Y B; Saadi, Y; Scott, I J; Walsh, J; Wu Sau Lan; Wu, X; Yamartino, J M; Zobernig, G

    1998-01-01

    The triple gauge-boson couplings, Awp, Aw and Abp, have been measured using 34 semileptonically and 54 hadronically decaying WW candidate events. The events were selected in the data recorded during 1996 with the ALEPH detector at 172 GeV, corresponding to an integrated luminosity of 10.65 pb^-1. The triple gauge-boson couplings have been measured using optimal observables constructed from kinematic information of WW events. The results are in agreement with the Standard Model expectation.

  6. Entrepreneurship, innovation and the triple helix model:\\ud evidence from Oxfordshire and Cambridgeshire

    OpenAIRE

    Lawton-Smith, Helen; Romeo, S.; Waters, R

    2013-01-01

    This paper focuses on how regions become entrepreneurial and the extent to which the actors in the triple helix model are dominant at particular stages in development. It uses the case studies of Oxfordshire and Cambridgeshire in the UK to explore this theme. Both can now be described as ‘regional triple helix spaces’ (Etzkowitz 2008), and form two points of the Golden Triangle of Oxford, Cambridge and London universities. As entrepreneurial regions, however, they differ in a number of respec...

  7. Triple P (Positive Parenting Program): Theoretischer und empirischer Hintergrund und erste Erfahrungen im deutschsprachigen Raum

    OpenAIRE

    Cina, Annette; Bodenmann, Guy; Hahlweg, Kurt; Dirscherl, Thomas; Sanders, Matthew R.

    2006-01-01

    'Dieser Artikel stellt die theoretischen, empirischen und klinischen Grundlagen eines mehrstufigen erziehungs- und familienunterstützenden Präventionsprogramms (Triple P: Positive Pa-renting Program) dar, welches die Förderung elterlicher Erziehungskompetenzen und die Reduktion von Verhaltensproblemen und emotionalen Störungen bei Kindern und Jugendlichen zum Ziel hat. Der Beitrag stellt die einzelnen Interventionsmethoden, Trainingselemente, Formen von Triple P und dessen Neuerungen sowie in...

  8. Triple P-Positive Parenting Program for Mothers of ADHD Children

    OpenAIRE

    Aghebati, Asma; Gharraee, Banafsheh; Hakim Shoshtari, Mitra; Gohari, Mahmood Reza

    2014-01-01

    Objective: Attention deficit hyperactivity disorder (ADHD) is a chronic, highly prevalent neurodevelopmental disorder which affects 9% of school-age children. Triple P-Positive Parenting Program is an evidence-based parenting program reported to be useful in the management of this disorder. The aim of this randomized controlled trial was to evaluate the effectiveness of Triple P in mothers of ADHD children. Methods: In this study, 30 mothers with ADHD children aged between 6 to 10 were random...

  9. Helping families change: The adoption of the Triple P - Positive Parenting Program in the Netherlands

    OpenAIRE

    de Graaf, I.M.

    2009-01-01

    In this thesis the implementation of the evidence-based Triple P Positive Parenting Program in the Netherlands was examined. Because parenting is associated with the wellbeing of children, parenting programs are developed to address the child problems. Among all developed parenting programs, the Behavioral Family Interventions (BFI) have the strongest empirical evidence. The aim of Triple P is to prevent and offer treatment for mild and severe behavioral, emotional and developmental problems ...

  10. Triple therapy versus sequential therapy for the first-line Helicobacter pylori eradication.

    Science.gov (United States)

    Chang, Ji Young; Shim, Ki-Nam; Tae, Chung Hyun; Lee, Ko Eun; Lee, Jihyun; Lee, Kang Hoon; Moon, Chang Mo; Kim, Seong-Eun; Jung, Hye-Kyung; Jung, Sung-Ae

    2017-01-21

    The eradication rate of Helicobacter pylori (H. pylori) with triple therapy which was considered as standard first-line treatment has decreased to 70-85%. The aim of this study is to compare 7-day triple therapy versus 10-day sequential therapy as the first line treatment. Data of 1240 H. pylori positive patients treated with triple therapy or sequential therapy from January 2013 to December 2015 were analyzed retrospectively. The patients who had undertaken previous H. pylori eradication therapy or gastric surgery were excluded. There were 872 (74.3%) patients in the triple therapy group, and 302 (25.7%) patients in the sequential therapy group. There was no significant difference between the two groups regarding age, residence, comorbidities or drug compliance, but several differences were noted in endoscopic characteristics and indication for the treatment. The eradication rate of H. pylori by intention to treat analysis was 64.3% in the triple therapy group, and 81.9% in the sequential therapy group (P = 0.001). In per protocol analysis, H. pylori eradication rate in the triple therapy and sequential therapy group was 81.9 and 90.3%, respectively (P = 0.002). There was no significant difference in overall adverse events between the two groups (P = 0.706). For the rescue therapy, bismuth-containing quadruple therapy showed comparable treatment efficacy after sequential therapy, as following triple therapy. The eradication rate of triple therapy was below the recommended threshold. Sequential therapy could be effective and tolerable candidate for the first-line H. pylori eradication therapy.

  11. Characterization of $SU_q(\\ell+1)$-equivariant spectral triples for the odd dimensional quantum spheres

    OpenAIRE

    Chakraborty, Partha Sarathi; Pal, Arupkumar

    2007-01-01

    The quantum group $SU_q(\\ell+1)$ has a canonical action on the odd dimensional sphere $S_q^{2\\ell+1}$. All odd spectral triples acting on the $L_2$ space of $S_q^{2\\ell+1}$ and equivariant under this action have been characterized. This characterization then leads to the construction of an optimum family of equivariant spectral triples having nontrivial $K$-homology class. These generalize the results of Chakraborty & Pal for $SU_q(2)$.

  12. [Study of collagen mimetic peptide's triple-helix structure and its thermostability by circular dichroism].

    Science.gov (United States)

    Zhang, Zhi-Bao; Wang, Jing-Jie; Chen, Hui-Juan; Xiong, Qing-Qing; Liu, Ling-Rong; Zhang, Qi-Qing

    2014-04-01

    In the present study, the authors explore the triple-helix conformation and thermal stability of collagen mimetic peptides (CMPs) as a function of peptide sequence and/or chain length by circular dichroism(CD). Five CMPs were designed and synthetized varying the number of POG triplets or incorporating an integrin alpha2beta1 binding motif Gly-Phe-Hyp-Gly-Glu-Arg (GFOGER). CD spectroscopy from 260 to 190 nm was recorded to confirm the existence of triple-helix conformation at room temperature, while thermal melting and thermal annealing of triple-helix (thermal unfolding and refolding of triple-helix, respectively) was characterized by monitoring ellipticity at 225 nm as a function of temperature. The results demonstrated that all the CMPs adopted triple-helix conformation, and the thermal stability of the CMPs was enhanced with increasing the number of POG triplets. In contrast to natural collagen, the thermal denaturation processes of CMPs were reversible, i. e. the triple-helix unfolded upon heating while refolded upon cooling. Meanwhile, the phenomenon of "hysteresis" was observed by comparing melting and thermal curves. These findings add new insights to the mechanisms of collagen and CMPs assembly, as well as provide an alternative approach to the fabrication of artificial collagen-likes biomaterials.

  13. Triple negative breast cancer patients presenting with low serum vitamin D levels: a case series

    Science.gov (United States)

    Khan, Yasir; Tisman, Glenn

    2009-01-01

    Introduction Serum vitamin D levels measured as 25-hydroxyvitamin D have been shown to be low in cancer patients, including breast cancer patients. However, the vitamin D status has yet to be studied in different breast cancer phenotypes: luminal A, luminal B, HER2+/ER-, and triple negative comprising the majority of basal-like. Case presentation Fifteen triple-negative breast cancer patients have presented to our medical oncology office in the last five years. Thirteen of these fifteen patients (87%) were found to be vitamin D deficient, defined as serum 25(OH)D less than 80 nmol/L, prior to initiation of adjuvant therapy. Ninety-one breast cancer patients from our office were classified as: luminal A (ER+ &/or PR+ and HER2-), luminal B (ER+ &/or PR+ and HER2+), HER2+/ER- (ER-, PR-, and HER2+), and triple-negative or basal-like (ER-, PR-, and HER2-). A normal mean was found from 78 volunteers. The breast cancer patients were found to be statistically different than the normal population. The triple-negative phenotype was found to be the most statistically different than the normal population. Conclusion The triple-negative breast cancer phenotype has the lowest average vitamin D level and the highest percentage of patients that are vitamin D deficient. These data suggests that low vitamin D levels are characteristic of the triple-negative phenotype. PMID:19830074

  14. Measurement uncertainty in single, double and triple isotope dilution mass spectrometry.

    Science.gov (United States)

    Vogl, Jochen

    2012-02-15

    Triple IDMS has been applied for the first time to the quantification of element concentrations. It has been compared with single and double IDMS obtained on the same sample set in order to evaluate the advantages and disadvantages of triple IDMS over single and double IDMS as an analytical reference procedure. The measurement results of single, double and triple IDMS are indistinguishable, considering rounding due to the individual measurement uncertainties. As expected, the relative expanded uncertainties (k = 2) achieved with double IDMS (0.08%) are dramatically smaller than those obtained with single IDMS (1.4%). Triple IDMS yields the smallest relative expanded uncertainties (k = 2, 0.077%) unfortunately at the expense of a much higher workload. Nevertheless triple IDMS has the huge advantage that the isotope ratio of the spike does not need to be determined. Elements with high memory effects, highly enriched spikes or highest metrological requirements may be typical applications for triple IDMS. Copyright © 2011 John Wiley & Sons, Ltd.

  15. Colligative properties of simple solutions.

    Science.gov (United States)

    Andrews, F C

    1976-11-05

    Vapor pressure lowering, osmotic pressure, boiling point elevation, and freezing point depression are all related quantitatively to the decrease in micro(1)(soln) upon the addition of solute in forming a solution. In any equilibrium system, regardless of whether it is in a gravitational field or whether it contains walls, semipermeable membranes, phase transitions, or solutes, all equilibria are maintained locally, in the small region of the equilibrium, by the equality of micro(1)(soln). If there are several subsystems in a gravitational field, at any fixed height, microi will have the same value in each subsystem into which substance i can get, and microi + M(i)gh is constant throughout the entire system. In a solution, there is no mechanism by which solvent and solute molecules could sustain different pressures. Both the solvent and solute are always under identical pressures in a region of solution, namely, the pressure of the solution in that region. Since nature does not know which component we call the solvent and which the solute, equations should be symmetric in the two (acknowledging that the nonvolatile component, if any, is commonly chosen to be solute). Simple molecular pictures illustrate what is happening to cause pressure (positive or negative) in liquids, vapor pressure of liquids, and the various colligative properties of solutions. The only effect of solute involved in these properties is that it dilutes the solvent, with the resulting increase in S and decrease in micro(1)(soln). Water can be driven passively up a tree to enormous heights by the difference between its chemical potential in the roots and the ambient air. There is nothing mysterious about the molecular bases for any of these phenomena. Biologists can use the well-understood pictures of these phenomena with confidence to study what is happening in the complicated living systems they consider.

  16. MPRINT: VAX printing made simple

    Energy Technology Data Exchange (ETDEWEB)

    Worlton, T.

    1994-08-01

    Users with stand-alone personal computers and personal printers usually find printing simple, but on a VAX computer or VAX cluster there may be many printers of different types located in different areas. The print queues set up for these printers may require different form qualifiers and may not all be able to print all documents. This article describes the basic steps a VAX system manager should take in setting up and managing print queues on a VAX and tells how to access these queues from a VAX, Unix, Macintosh, or DOS Computer. It gives a basic overview, but includes several helpful items that are obscure or completely undocumented. Following this overview, there is a description of a Fortran program, MPRINT, written to simplify printing for users. The MPRINT program simplifies the choice of printers and print forms for users of VAX print queues by allowing them to select from a one line per queue menu. The menu includes queue descriptions and only lists printers which can correctly print the specified file. MPRINT selects the correct form to use based on file type and maximum record length of the file. MPRINT may be useful at your site, and provides examples of a number of system services. MPRINT includes routines to do a user open of a file and get information from the File and Record Access Blocks (FAB and RAB), and a routine to obtain information about print queues. There are also routines to parse a file name, detab a character buffer, and trim trailing nulls and blanks from a character string.

  17. Accuracy of Triple Diagnostic Test in Patients with Thyroid Nodule at Dr. Cipto Mangunkusumo General Hospital

    Directory of Open Access Journals (Sweden)

    Gunawan Wibisana

    2017-04-01

    Full Text Available The aim of the study is to evaluate the accuracy of triple diagnostic test on thyroid nodules. The data from patients’ medical records who came to Cipto Mangunkusumo General Hospital for the first time or for evaluation of thyroid nodule and patients who underwent thyroidectomy during 2010 to 2011. Clinical examination was scored by McGill Thyroid Nodule Score. ROC procedure was performed to obtain clinical cut-off scores of diagnosis of malignant. Ultrasonography (USG result was considered malignant for TIRADS 4, 5, and 6. If clinical, USG and histopathology examinations of triple diagnostic give positive results, it will be classified as concordant malignant whereas if all those three show benign results, the classification is benign. Thyroid carcinoma was found in 134 out of 161 patients with thyroid nodule. There were 84 patients with concordant results for all three elements of the triple test. Out of 84 patients with concordant triple diagnostic results, there were 53 malignant cases (32.9% and 31 benign cases (19.3%. Main histopathological findings among patients with thyroid carcinoma was papillary (90.3%, follicular (3%, medullary (0.7%, and anaplastic (6%. The sensitivity and specificity of triple diagnostic was 77% and 94%, with positive predictive value of 98%, negative predictive value of 51,6% and accuracy of 80.9%. Combination of clinical findings, USG, and FNAB gave malignant probability of 92%, better than combination of clinical findings and USG (81.6% or clinical findings and FNAB (87%. Triple diagnostic cannot be used as an ideal test to replace frozen section examination in managing thyroid nodule. However, in cases with concordant results of each triple diagnostic’s element, the positive predictive value (98% and malignant probability (92% is high. Keywords: thyroid nodule, triple diagnostic, accuracy.   Akurasi Metode Triple Diagnostic pada Pasien Nodul Tiroid  di RSUPN Dr. Cipto Mangunkusumo   Abstrak Tujuan

  18. Androgen receptor as a mediator and biomarker of radioresistance in triple-negative breast cancer.

    Science.gov (United States)

    Speers, Corey; Zhao, Shuang G; Chandler, Ben; Liu, Meilan; Wilder-Romans, Kari; Olsen, Eric; Nyati, Shyam; Ritter, Cassandra; Alluri, Prasanna G; Kothari, Vishal; Hayes, Daniel F; Lawrence, Theodore S; Spratt, Daniel E; Wahl, Daniel R; Pierce, Lori J; Feng, Felix Y

    2017-01-01

    Increased rates of locoregional recurrence have been observed in triple-negative breast cancer despite chemotherapy and radiation therapy. Thus, approaches that combine therapies for radiosensitization in triple-negative breast cancer are critically needed. We characterized the radiation therapy response of 21 breast cancer cell lines and paired this radiation response data with high-throughput drug screen data to identify androgen receptor as a top target for radiosensitization. Our radiosensitizer screen nominated bicalutamide as the drug most effective in treating radiation therapy-resistant breast cancer cell lines. We subsequently evaluated the expression of androgen receptor in >2100 human breast tumor samples and 51 breast cancer cell lines and found significant heterogeneity in androgen receptor expression with enrichment at the protein and RNA level in triple-negative breast cancer. There was a strong correlation between androgen receptor RNA and protein expression across all breast cancer subtypes (R(2) = 0.72, p triple-negative breast cancer, expression of androgen receptor above the median was associated with increased risk of locoregional recurrence after radiation therapy (hazard ratio for locoregional recurrence 2.9-3.2)) in two independent data sets, but there was no difference in locoregional recurrence in triple-negative breast cancer patients not treated with radiation therapy when stratified by androgen receptor expression. In multivariable analysis, androgen receptor expression was most significantly associated with worse local recurrence-free survival after radiation therapy (hazard ratio of 3.58) suggesting that androgen receptor expression may be a biomarker of radiation response in triple-negative breast cancer. Inhibition of androgen receptor with MDV3100 (enzalutamide) induced radiation sensitivity (enhancement ratios of 1.22-1.60) in androgen receptor-positive triple-negative breast cancer lines, but did not affect androgen

  19. A clinicopathologic study of triple negative breast cancer

    Directory of Open Access Journals (Sweden)

    Vandana L Gaopande

    2015-01-01

    Full Text Available Background: Triple negative breast cancers (TNBC are defined by absence of estrogen and progesterone receptors (ER and PR and absence of overexpression of human epidermal growth factor receptor 2 (Her2. They are associated with poor prognosis. The purpose of this study is to study the clinicopathologic parameters of TNBC such as age, tumor size, stage, grade, and lymph node involvement and compare them with nonTNBC tumors. There are many studies which have shown that TNBC are similar to basal-like breast cancers (BBC. We have found the proportion of BBC in the TNBC group using surrogate immunohistochemical (IHC markers cytokeratin5 (CK5 and epidermal growth factor receptor (EGFR. Materials and Methods : This is a retrospective study of 102 cases of carcinoma breast. Clinical records of the cases were retrieved. Histopathology slides and the IHC slides (ER, PR, Her2 were reviewed. Thus, two groups of patients were made TNBC and nonTNBC. Using the software SPSS version 16 statistical significance of the difference between clinicopathologic variables of the two groups was calculated. TNBC group was later studied for the presence of basal markers CK5 and EGFR using tissue microarray. Results: Statistically significant difference was found between the two groups in the variables such as mean age at diagnosis, mean tumor size, tumor grade, and the presence of lymphovascular invasion. Conclusions: TNBC formed 23.5% of total cases. Overall, TNBC were high grade tumors with larger size at diagnosis, presenting in younger women and showing lymphovascular invasion in a higher number of cases. 87.5% of TNBC were BBC.

  20. TMEPAI genome editing in triple negative breast cancer cells

    Directory of Open Access Journals (Sweden)

    Bantari W.K. Wardhani

    2017-05-01

    Full Text Available Background: Clustered regularly interspaced short palindromic repeats/CRISPR-associated 9 (CRISPR/Cas9 is a powerful genome editing technique. It consists of RNA-guided DNA endonuclease Cas9 and single guide RNA (gRNA. By combining their expressions, high efficiency cleavage of the target gene can be achieved, leading to the formation of DNA double-strand break (DSB at the genomic locus of interest which will be repaired via NHEJ (non-homologous end joining or HDR (homology-directed repair and mediate DNA alteration. We aimed to apply the CRISPR/Cas9 technique to knock-out the transmembrane prostate androgen-induced protein (TMEPAI gene in the triple negative breast cancer cell line.Methods: Designed gRNA which targets the TMEPAI gene was synthesized, annealed, and cloned into gRNA expression vector. It was co-transfected into the TNBC cell line using polyethylenimine (PEI together with Cas9-GFP and puromycin resistant gene vector. At 24-hours post-transfection, cells were selected by puromycin for 3 days before they were cloned. Selected knock-out clones were subsequently checked on their protein levels by western blotting.Results: CRISPR/Cas9, a genome engineering technique successfully knocked-out TMEPAI in the Hs578T TNBC cell line. Sequencing shows a frameshift mutation in TMEPAI. Western blot shows the absence of TMEPAI band on Hs578T KO cells.Conclusion: TMEPAI gene was deleted in the TNBC cell line using the genomic editing technique CRISPR/Cas9. The deletion was confirmed by genome and protein analysis.

  1. Trends of triple negative breast cancer research (2007–2015)

    Science.gov (United States)

    Wang, Yiran; Zhai, Xiao; Liu, Chuan; Wang, Ning; Wang, Yajie

    2016-01-01

    Abstract Background: Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype. However, there have been limited data to evaluate the trend of TNBC research. This study aims to investigate the trend of TNBC research and compare the contribution of research from different regions, organizations, and authors. Methods: TNBC-related publications from 2007 to 2015 were retrieved from the Web of Science database. Excel 2013 (Redmond, Washington, USA), GraphPad Prism 5 (GraphPad Prism Software Inc., San Diego, CA), and VOSviewer (Leiden University, Leiden, Netherlands) software were used to analyze the trend of TNBC research. This article does not contain any studies with human participants or animals performed by any of the authors. Results: A total of 1695 papers were identified and were cited 34,078 times with a time limit of May 27, 2016. The United States accounted for 43.10% of the articles, 57.59% of the citations, and the highest H-index (64). China ranked second in total number of articles, but seventh in citation frequency (1998) and ninth in H-index (21). The journal Breast Cancer Research and Treatment had the highest number of publications. The author, Narod SA, has published the most papers in this field (30). The keyword “receptor” was mentioned the most, 1489 times, and the word “myeloid cell leukemia-1 (MCL-1)” was the latest hot spot by 2015. Conclusion: Literature growth related to TNBC is expanding rapidly in recent years. The quality of the articles from China still requires improvement. Newest progress of the TNBC research may be released by the journal Breast Cancer Research and Treatment first. Narod SA, Gonzalez-Angulo AM, and Hortobagyi GN may be good candidates for collaborative research in this field. MCL-1 is an emerging topic that should be closely observed. PMID:27861384

  2. "An addendum to breast cancer": the triple negative experience.

    Science.gov (United States)

    Turkman, Yasemin E; Kennedy, Holly Powell; Harris, Lyndsay N; Knobf, M Tish

    2016-09-01

    The triple negative breast cancer (TNBC) subtype, known to be aggressive with high recurrence and mortality rates, disproportionately affects African-Americans, young women, and BRCA1 carriers. TNBC does not respond to hormonal or biologic agents, limiting treatment options. The unique characteristics of the disease and the populations disproportionately affected indicate a need to examine the responses of this group. No known studies describe the psychosocial experiences of women with TNBC. The purpose of this study is to begin to fill that gap and to explore participants' psychosocial needs. An interpretive descriptive qualitative approach was used with in-depth interviews. A purposive sample of adult women with TNBC was recruited. Dominant themes were extracted through iterative and constant comparative analysis. Of the 22 participants, nearly half were women of color, and the majority was under the age of 60 years and within 5 years of diagnosis. The central theme was a perception of TNBC as "an addendum" to breast cancer. There were four subthemes: TNBC is Different: "Bottom line, it's not good"; Feeling Insecure: "Flying without a net"; Decision-Making and Understanding: "A steep learning curve"; and Looking Back: "Coulda, shoulda, woulda." Participants expressed a need for support in managing intense uncertainty with a TNBC diagnosis and in decision-making. Women with all subtypes of breast cancer have typically been studied together. This is the first study on the psychosocial needs specifically of women with TNBC. The findings suggest that women with TNBC may have unique experiences and unmet psychosocial needs.

  3. Intratumor heterogeneity predicts metastasis of triple-negative breast cancer.

    Science.gov (United States)

    Yang, Fang; Wang, Yucai; Li, Quan; Cao, Lulu; Sun, Zijia; Jin, Juan; Fang, Hehui; Zhu, Aiyu; Li, Yan; Zhang, Wenwen; Wang, Yanru; Xie, Hui; Gustafsson, Jan-Åke; Wang, Shui; Guan, Xiaoxiang

    2017-09-01

    Even with the identical clinicopathological features, the ability for metastasis is vastly different among triple-negative breast cancer (TNBC) patients. Intratumor heterogeneity (ITH), which is common in breast cancer, may be a key mechanism leading to the tumor progression. In this study, we studied whether a quantitative genetic definition of ITH can predict clinical outcomes in patients with TNBC. We quantified ITH by calculating Shannon index, a measure of diversity in a population, based on Myc, epidermal growth factor receptor/centromeric probe 7 (EGFR/CEP7) and cyclin D1/centromeric probe 11 (CCND1/CEP11) copy number variations (CNVs) in 300 cells at three different locations of a tumor. Among 75 TNBC patients, those who developed metastasis had significantly higher ITH, that is Shannon indices of EGFR/CEP7 and CCND1/CEP11 CNVs. Higher Shannon indices of EGFR/CEP7 and CCND1/CEP11 CNVs were significantly associated with the development of metastasis and were predictive of significantly worse metastasis-free survival (MFS). Regional heterogeneity, defined as the difference in copy numbers of Myc, EGFR or CCND1 at different locations, was found in 52 patients. However, the presence of regional heterogeneity did not correlate with metastasis or MFS. Our findings demonstrate that higher ITH of EGFR/CEP7 and CCND1/CEP11 CNVs is predictive of metastasis and is associated with significantly worse MFS in TNBC patients, suggesting that ITH is a very promising novel prognostic factor in TNBC. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  4. [Premature immunosenescence in triple-transgenic mice for Alzheimer's disease].

    Science.gov (United States)

    Mate, Ianire; Cruces, Julia; Vida, Carmen; Sanfeliu, Coral; Manassra, Rashed; Giménez-Llort, Lydia; De la Fuente, Mónica

    2014-01-01

    A deterioration of the neuroimmunoendocrine network has been observed in Alzheimer's disease (AD). However, the peripheral immune response has hardly been investigated in this pathology. Since some immune function parameters have been established as good markers of the rate of ageing, and can predict longevity, the aim of the present work was to study some of these functions in splenic leucocytes in transgenic mice for AD of different ages. Young female (4 ± 1 months), adult (9 ± 1 months), and mature (12 ± 1 months) triple-transgenic mice for AD (3 xTgAD) and non-transgenic (NTg) control mice of the same ages were used. The chemotaxis, the anti-tumour activity of « natural killer » (NK) cells and the lymphoproliferative response in the presence of the mitogens concanavalin A and lipopolysaccharide, functions that decrease with age, were determined in splenic leucocytes. In addition, the differences in lifespan between 3 xTgAD and NTg were studied in parallel using other animals, until their death through natural causes. In 3 xTgAD, with respect to NTg, chemotaxis decreased at all ages studied, whereas in lymphoproliferative response this reduction was shown at 4 months and 9 months. NK activity was diminished only in young 3 xTgAD with respect to NTg. The 3 xTgAD showed a shorter lifespan than the NTg control group. The 3 xTgAD mice show a premature immunosenescence, which could explain their early mortality. The determination of these immune functions at peripheral level could serve as a marker of the progression of the Alzheimer's disease. Copyright © 2013 SEGG. Published by Elsevier Espana. All rights reserved.

  5. Folate receptor-α (FOLR1 expression and function in triple negative tumors.

    Directory of Open Access Journals (Sweden)

    Brian M Necela

    Full Text Available Folate receptor alpha (FOLR1 has been identified as a potential prognostic and therapeutic target in a number of cancers. A correlation has been shown between intense overexpression of FOLR1 in breast tumors and poor prognosis, yet there is limited examination of the distribution of FOLR1 across clinically relevant breast cancer subtypes. To explore this further, we used RNA-seq data from multiple patient cohorts to analyze the distribution of FOLR1 mRNA across breast cancer subtypes comprised of estrogen receptor positive (ER+, human epidermal growth factor receptor positive (HER2+, and triple negative (TNBC tumors. FOLR1 expression varied within breast tumor subtypes; triple negative/basal tumors were significantly associated with increased expression of FOLR1 mRNA, compared to ER+ and HER2+ tumors. However, subsets of high level FOLR1 expressing tumors were observed in all clinical subtypes. These observations were supported by immunohistochemical analysis of tissue microarrays, with the largest number of 3+ positive tumors and highest H-scores of any subtype represented by triple negatives, and lowest by ER+ tumors. FOLR1 expression did not correlate to common clinicopathological parameters such as tumor stage and nodal status. To delineate the importance of FOLR1 overexpression in triple negative cancers, RNA-interference was used to deplete FOLR1 in overexpressing triple negative cell breast lines. Loss of FOLR1 resulted in growth inhibition, whereas FOLR1 overexpression promoted folate uptake and growth advantage in low folate conditions. Taken together, our data suggests patients with triple negative cancers expressing high FOLR1 expression represent an important population of patients that may benefit from targeted anti-FOLR1 therapy. This may prove particularly helpful for a large number of patients who would typically be classified as triple negative and who to this point have been left without any targeted treatment options.

  6. Binary Black Hole Mergers from Field Triples: Properties, Rates, and the Impact of Stellar Evolution

    Energy Technology Data Exchange (ETDEWEB)

    Antonini, Fabio [Center for Interdisciplinary Exploration and Research in Astrophysics (CIERA) and Department of Physics and Astrophysics, Northwestern University, Evanston, IL 60208 (United States); Toonen, Silvia [Astronomical Institute Anton Pannekoek, University of Amsterdam, P.O. Box 94249, 1090 GE, Amsterdam (Netherlands); Hamers, Adrian S. [Institute for Advanced Study, School of Natural Sciences, Einstein Drive, Princeton, NJ 08540 (United States)

    2017-06-01

    We consider the formation of binary black hole (BH) mergers through the evolution of field massive triple stars. In this scenario, favorable conditions for the inspiral of a BH binary are initiated by its gravitational interaction with a distant companion, rather than by a common-envelope phase invoked in standard binary evolution models. We use a code that follows self-consistently the evolution of massive triple stars, combining the secular triple dynamics (Lidov–Kozai cycles) with stellar evolution. After a BH triple is formed, its dynamical evolution is computed using either the orbit-averaged equations of motion, or a high-precision direct integrator for triples with weaker hierarchies for which the secular perturbation theory breaks down. Most BH mergers in our models are produced in the latter non-secular dynamical regime. We derive the properties of the merging binaries and compute a BH merger rate in the range (0.3–1.3) Gpc{sup −3} yr{sup −1}, or up to ≈2.5 Gpc{sup −3} yr{sup −1} if the BH orbital planes have initially random orientation. Finally, we show that BH mergers from the triple channel have significantly higher eccentricities than those formed through the evolution of massive binaries or in dense star clusters. Measured eccentricities could therefore be used to uniquely identify binary mergers formed through the evolution of triple stars. While our results suggest up to ≈10 detections per year with Advanced-LIGO, the high eccentricities could render the merging binaries harder to detect with planned space based interferometers such as LISA.

  7. Pattern of triple negative epithelial ovarian cancer in indigenous African women [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Mustapha Akanji Ajani

    2016-09-01

    Full Text Available Background: Triple negative epithelial ovarian cancer (TNEOC  refers to ovarian carcinomas that do not express estrogen receptor (ER, progesterone receptor (PR and human epidermal growth factor receptor- type 2 (HER-2/neu.  The aim of this study is to determine the pattern of triple negative epithelial ovarian cancer in indigenous African women. Methods: We performed a retrospective review of ER, PR and HER-2/neu expression in 90 Nigerian patients with histologically diagnosed epithelial ovarian cancer. Lack of expression of ER, PR and HER2/neu antigens was used to determine carcinomas that are among the TNEOC. We also compared the clinicopathological parameters (age, International Federation of Gynaecology and Obstetrics (FIGO stage, grade and histological subtype in patients with TNEOC and non- TNEOC . Results: Thirty-eight (42.2% of the 90 tumours diagnosed as EOC were negative for ER, PR and HER2/neu expression. There was no significant association between TNEOC with other parameters such as age, FIGO stage and histological grade. Sixteen (66.7% of the 24 mucinous carcinomas were triple negative, while only 21 (33.3% of the 63 serous carcinomas were triple-negative and one (50% of the two endometrioid carcinomas was triple negative. There was a significant association between triple-negative tumours and histological subtypes of EOC (p = 0.034. Conclusions: A subtype of epithelial ovarian cancer that is negative for ER, PR and HER-2/neu has been discovered in indigenous African women. TNEOC expression is high and is comparable to the triple negative breast cancer subtype seen in people of African ancestry. Future study of TNEOC in a large sample size should be considered.

  8. Targeted chemotherapy for triple-negative breast cancers via LHRH receptor.

    Science.gov (United States)

    Föst, Crispin; Duwe, Francesca; Hellriegel, Martin; Schweyer, Stefan; Emons, Günter; Gründker, Carsten

    2011-05-01

    Triple-negative breast cancer does not express estrogen and progesterone receptors and there is no overexpression/amplification of the HER2-neu gene. Therefore, this subtype of breast cancer lacks the benefits of specific therapies which target these receptors. About 60% of all human breast cancers express receptors for luteinizing hormone releasing hormone (LHRH, GnRH), which might be used as a target. The LHRH receptor can be used for targeted chemotherapy with cytotoxic luteinizing hormone releasing hormone agonists such as AEZS-108 (AN-152), in which doxorubicin is linked to [D-Lys6]LHRH. In the present study we have analyzed by in vitro and in vivo experiments whether the cytotoxic LHRH agonist AEZS-108 (AN-152) induces apoptosis in triple-negative human breast cancer cells that express LHRH receptors. LHRH receptor expression in tumor biopsy specimens of triple-negative breast cancers was tested using immunohistochemistry. Cell proliferation was analyzed using alamar blue proliferation assay. Induction of apoptosis was quantified by measurement of loss of mitochondrial membrane potential. In vivo experiments were performed using nude mice bearing xenografted human breast tumors.Thirty-one of 42 triple-negative breast cancers (73.8%) expressed LHRH receptors. We could show that treatment of triple-negative but LHRH-positive MDA-MB-231, HCC1806 and HCC1937 human breast cancer cells with AEZS-108 (AN-152) resulted in apoptotic cell death in vitro via activation of caspase-3. The antitumor effects were confirmed in nude mice. AEZS-108 (AN-152) inhibited the growth of xenotransplants of triple-negative human breast cancers in nude mice completely, without any apparent side effects. The cytotoxic LHRH agonist AEZS-108 (AN-152) seems to be a suitable drug for an efficacious therapy for triple-negative breast cancers with little toxicity.

  9. A novel triple-layer zinc oxide/carbon nanotube architecture for dye-sensitized solar cells with excellent power conversion efficiency

    Science.gov (United States)

    Hu, Jing; Xie, Yahong; Bai, Te; Zhang, Chunyang; Wang, Jide

    2015-07-01

    A novel triple-layer photoanode architecture, composed of ZnO and ZnO/CNT nanostructure semiconductor films for dye-sensitized solar cell with excellent power conversion efficiency is fabricated by a simple strategy. A convenient and effective method is applied to disperse the multiwalled carbon nanotube (MWCNT). The structure, morphology and light absorption of the novel hybrid photoanode are characterized by X-ray diffraction, scanning electron microscopy, and UV-vis absorption spectroscopy analyze. Results indicate that the ZnO has a typical wurtzite structure and the MWCNTs are homogeneously dispersed in ZnO. Current-voltage curves demonstrate CNT-0.5 with 0.05wt% of carbon nanotube (CNT) is the most suitable in improving the performance of DSSCs, and the power conversion efficiency of ZnO/CNT-0.5-0.05wt% is 6.25%, which is 35.57% higher than those without CNTs (4.61%). Finally, electrochemical impedance spectra confirms that the abundant dyes absorption by the ZnO layer and large numbers of direct pathway for electron transport provided by the MWCNTs are attributed to the high efficiency of this new DSSC. This result is remarkable and provides a novel triple-layer ZnO/CNT architecture in improving the performance of DSSCs.

  10. The hierarchical stability of the seven known large size ratio triple asteroids using the empirical stability parameters.

    Science.gov (United States)

    Liu, Xiaodong; Baoyin, Hexi; Marchis, Franck

    In this study, the hierarchical stability of the seven known large size ratio triple asteroids is investigated. The effect of the solar gravity and primary's J 2 are considered. The force function is expanded in terms of mass ratios based on the Hill's approximation and the large size ratio property. The empirical stability parameters are used to examine the hierarchical stability of the triple asteroids. It is found that the all the known large size ratio triple asteroid systems are hierarchically stable. This study provides useful information for future evolutions of the triple asteroids.

  11. Training GPs in parent consultation skills: an evaluation of training for the Triple P-Positive Parenting Program

    National Research Council Canada - National Science Library

    Sanders, MR; Turner, KM; Maher, C; Tully, LA; McAuliffe, C

    2003-01-01

    BACKGROUND: The Triple P-Positive Parenting Program is a behavioural family intervention program that aims to prevent severe behavioral, emotional and developmental problems in children by enhancing...

  12. Triple oxygen isotopes in biogenic and sedimentary carbonates

    Science.gov (United States)

    Passey, Benjamin H.; Hu, Huanting; Ji, Haoyuan; Montanari, Shaena; Li, Shuning; Henkes, Gregory A.; Levin, Naomi E.

    2014-09-01

    The 17O anomaly (Δ17O) of natural waters has been shown to be sensitive to evaporation in a way analogous to deuterium excess, with evaporated bodies of water (e.g., leaf waters, lake waters, animal body waters) tending to have lower Δ17O than primary meteoric waters. In animal body water, Δ17O relates to the intake of evaporated waters, evaporative effluxes of water, and the Δ17O value of atmospheric O2, which itself carries signatures of global carbon cycling and photochemical reactions in the stratosphere. Carbonates have the potential to record the triple oxygen isotope compositions of parent waters, allowing reconstruction of past water compositions, but such investigations have awaited development of methods for high-precision measurement of Δ17O of carbonate. We describe optimized methods based on a sequential acid digestion/reduction/fluorination approach that yield Δ17O data with the high precision (∼0.010‰, 1σ) needed to resolve subtle environmental signals. We report the first high-precision Δ17O dataset for terrestrial carbonates, focusing on vertebrate biogenic carbonates and soil carbonates, but also including marine invertebrates and high-temperature carbonates. We determine apparent three-isotope fractionation factors between the O2 analyte derived from carbonate and the parent waters of the carbonate. These in combination with appropriate temperature estimates (from clumped isotope thermometry, or known or estimated body temperatures) are used to calculate the δ18O and Δ17O of parent waters. The clearest pattern to emerge is the strong 17O-depletion in avian, dinosaurian, and mammalian body water (from analyses of eggshell and tooth enamel) relative to meteoric waters, following expected influences of evaporated water (e.g., leaf water) and atmospheric O2 on vertebrate body water. Parent waters of the soil carbonates studied here have Δ17O values that are similar to or slightly lower than global precipitation. Our results suggest

  13. Engineering Remotely Triggered Liposomes to Target Triple Negative Breast Cancer

    Science.gov (United States)

    Sneider, Alexandra; Jadia, Rahul; Piel, Brandon; VanDyke, Derek; Tsiros, Christopher; Rai, Prakash

    2017-01-01

    Triple Negative Breast Cancer (TNBC) continues to present a challenge in the clinic, as there is still no approved targeted therapy. TNBC is the worst sub-type of breast cancer in terms of prognosis and exhibits a deficiency in estrogen, progesterone, and human epidermal growth factor 2 (HER2) receptors. One possible option for the treatment of TNBC is chemotherapy. The issue with many chemotherapy drugs is that their effectiveness is diminished due to poor water solubility, and the method of administration directly or with a co-solvent intravenously can lead to an increase in toxicity. The issues of drug solubility can be avoided by using liposomes as a drug delivery carrier. Liposomes are engineered, biological nanoconstructs that possess the ability to encapsulate both hydrophobic and hydrophilic drugs and have been clinically approved to treat cancer. Specific targeting of cancer cell receptors through the use of ligands conjugated to the surface of drug-loaded liposomes could lessen damage to normal, healthy tissue. This study focuses on polyethylene glycol (PEG)-coated, folate conjugated, benzoporphyrin derivative (BPD)-loaded liposomes for treatment via photodynamic therapy (PDT). The folate receptor is over expressed on TNBC cells so these liposomes are targeted for greater uptake into cancer cells. PDT involves remotely irradiating light at 690 nm to trigger BPD, a hydrophobic photosensitive drug, to form reactive oxygen species that cause tumor cell death. BPD also displays a fluorescence signal when excited by light making it possible to image the fluorescence prior to PDT and for theranostics. In this study, free BPD, non-targeted and folate-targeted PEGylated BPD-loaded liposomes were introduced to a metastatic breast cancer cell line (MDA-MB-231) in vitro. The liposomes were reproducibly synthesized and characterized for size, polydispersity index (PDI), zeta potential, stability, and BPD release kinetics. Folate competition tests, fluorescence

  14. Preliminary Low Temperature Electron Irradiation of Triple Junction Solar Cells

    Science.gov (United States)

    Stella, Paul M.; Mueller, Robert L.; Scrivner, Roy L.; Helizon, Roger S.

    2007-01-01

    For many years extending solar power missions far from the sun has been a challenge not only due to the rapid falloff in solar intensity (intensity varies as inverse square of solar distance) but also because some of the solar cells in an array may exhibit a LILT (low intensity low temperature) degradation that reduces array performance. Recent LILT tests performed on commercial triple junction solar cells have shown that high performance can be obtained at solar distances as great as approx. 5 AU1. As a result, their use for missions going far from the sun has become very attractive. One additional question that remains is whether the radiation damage experienced by solar cells under low temperature conditions will be more severe than when measured during room temperature radiation tests where thermal annealing may take place. This is especially pertinent to missions such as the New Frontiers mission Juno, which will experience cell irradiation from the trapped electron environment at Jupiter. Recent testing2 has shown that low temperature proton irradiation (10 MeV) produces cell degradation results similar to room temperature irradiations and that thermal annealing does not play a factor. Although it is suggestive to propose the same would be observed for low temperature electron irradiations, this has not been verified. JPL has routinely performed radiation testing on commercial solar cells and has also performed LILT testing to characterize cell performance under far sun operating conditions. This research activity was intended to combine the features of both capabilities to investigate the possibility of any room temperature annealing that might influence the measured radiation damage. Although it was not possible to maintain the test cells at a constant low temperature between irradiation and electrical measurements, it was possible to obtain measurements with the cell temperature kept well below room temperature. A fluence of 1E15 1MeV electrons was

  15. Underworld results as a triple (shopping list, posterior, priors)

    Science.gov (United States)

    Quenette, S. M.; Moresi, L. N.; Abramson, D.

    2013-12-01

    When studying long-term lithosphere deformation and other such large-scale, spatially distinct and behaviour rich problems, there is a natural trade-off between the meaning of a model, the observations used to validate the model and the ability to compute over this space. For example, many models of varying lithologies, rheological properties and underlying physics may reasonably match (or not match) observables. To compound this problem, each realisation is computationally intensive, requiring high resolution, algorithm tuning and code tuning to contemporary computer hardware. It is often intractable to use sampling based assimilation methods, but with better optimisation, the window of tractability becomes wider. The ultimate goal is to find a sweet-spot where a formal assimilation method is used, and where a model affines to observations. Its natural to think of this as an inverse problem, in which the underlying physics may be fixed and the rheological properties and possibly the lithologies themselves are unknown. What happens when we push this approach and treat some portion of the underlying physics as an unknown? At its extreme this is an intractable problem. However, there is an analogy here with how we develop software for these scientific problems. What happens when we treat the changing part of a largely complete code as an unknown, where the changes are working towards this sweet-spot? When posed as a Bayesian inverse problem the result is a triple - the model changes, the real priors and the real posterior. Not only does this give meaning to the process by which a code changes, it forms a mathematical bridge from an inverse problem to compiler optimisations given such changes. As a stepping stone example we show a regional scale heat flow model with constraining observations, and the inverse process including increasingly complexity in the software. The implementation uses Underworld-GT (Underworld plus research extras to import geology and export

  16. Triple Negative Breast Cancer in Pregnancy and Postpartum: Two Case Reports in Hispanic Women

    Directory of Open Access Journals (Sweden)

    Ruchi Upadhyay

    2015-01-01

    Full Text Available Objective. Despite studies suggesting that triple negative breast cancer is more often seen in women of African ancestry, we report here two cases of pregnancy associated triple negative breast cancer in Hispanic women. Cases. Case one is a 37-year-old female para 2-0-0-2, who presented with a left breast mass, at 19 weeks of gestation, the biopsy of which reported an invasive ductal carcinoma, found to be triple receptor negative. The patient underwent chemotherapy during the pregnancy and was delivered with a cesarean at 37 weeks for obstetric indication. After delivery, the patient completed her chemotherapy that was followed by radical mastectomy and radiotherapy. Case two is a 28-year-old female para 6-0-1-5, who presented while breast-feeding with signs and symptoms of mastitis, and an engorged and tender right breast, five months postpartum. However, the sonogram revealed a fluid filled cavity. Aspiration and cytology did not reflect an infection and were negative for malignancy. High suspicion and lack of improvement led to biopsy that identified an invasive ductal carcinoma, found to be triple negative. The patient underwent chemotherapy followed by modified radical mastectomy. Conclusions. Triple negative breast cancer, during pregnancy or postpartum, poses a unique challenge and requires a multidisciplinary team to optimize treatment for these women.

  17. Triple vs. dual antiplatelet therapy in patients with acute myocardial infarction and renal dysfunction.

    Science.gov (United States)

    Choi, Young Hwan; Suh, Sang Heon; Choi, Joon Seok; Kim, Chang Seong; Sim, Doo Sun; Bae, Eun Hui; Lim, Sang Yup; Ma, Seong Kwon; Jeong, Myung Ho; Kim, Soo Wan

    2012-01-01

     The question as to whether triple antiplatelet therapy is superior to dual antiplatelet therapy for patients with acute myocardial infarction (AMI) and renal dysfunction, who undergo percutaneous coronary intervention (PCI), is unresolved.  As part of the Korea Acute Myocardial Infarction Registry (KAMIR), 2,288 AMI patients with renal dysfunction (glomerular filtration rate aspirin plus clopidogrel; n=1,587) or triple (aspirin plus clopidogrel and cilostazol; n=701) antiplatelet therapy. Major adverse cardiac events (MACE) at 1 month and 1 year were compared between these 2 groups. On comparison with the dual therapy group, the triple therapy group had a similar incidence of major bleeding events but a significantly lower incidence of in-hospital mortality. The MACE rate at 1 month was significantly higher for the dual therapy group than for the triple therapy group (16.3% vs. 11.1%, P<0.05), and this difference was mainly attributed to death rather than repeat PCI (12.9% vs. 9.1%, P<0.05). The MACE rate at 1 year and the MACE-free survival time, however, did not differ between the groups.  In AMI patients with renal dysfunction, triple antiplatelet therapy has a favorable in-hospital and short-term MACE impact, but it does not have an impact on the 1-year MACE-free survival.

  18. The BDS Triple Frequency Pseudo-range Correlated Stochastic Model of Single Station Modeling Method

    Directory of Open Access Journals (Sweden)

    HUANG Lingyong

    2017-05-01

    Full Text Available In order to provide a reliable pseudo-range stochastic model, a method is studied to estimate the BDS triple-frequency pseudo-range related stochastic model based on three BDS triple-frequency pseudo-range minus carrier (GIF combinations using the data of a single station. In this algorithm, the low order polynomial fitting method is used to fit the GIF combination in order to eliminate the error and other constants except non pseudo noise at first. And then, multiple linear regression analysis method is used to model the stochastic function of three linearly independent GIF combinations. Finally the related stochastic model of the original BDS triple-frequency pseudo-range observations is obtained by linear transformation. The BDS triple-frequency data verification results show that this algorithm can get a single station related stochastic model of BDS triple-frequency pseudo-range observation, and it is advantageous to provide accurate stochastic model for navigation and positioning and integrity monitoring.

  19. Triple p-positive parenting program for mothers of ADHD children.

    Science.gov (United States)

    Aghebati, Asma; Gharraee, Banafsheh; Hakim Shoshtari, Mitra; Gohari, Mahmood Reza

    2014-01-01

    Attention deficit hyperactivity disorder (ADHD) is a chronic, highly prevalent neurodevelopmental disorder which affects 9% of school-age children. Triple P-Positive Parenting Program is an evidence-based parenting program reported to be useful in the management of this disorder. The aim of this randomized controlled trial was to evaluate the effectiveness of Triple P in mothers of ADHD children. In this study, 30 mothers with ADHD children aged between 6 to 10 were randomly assigned to two groups (15 participants in each group). Parenting style, mother-child relationship, maternal depression, anxiety and stress, and children's behavioral problems were evaluated. The intervention group received 120 minute sessions for 5 weeks and 15-30 minute telephone contacts for 3 weeks while no intervention was done for the control group. Analysis of covariance revealed that mothers of the Triple P group showed significant (p parenting style, mother-child relationship, and considerable decrease in depression, anxiety and stress. Women trained in the Triple P group also reported significantly lower rates of child misbehavior than women of the control group. Triple P-Positive Parenting intervention is effective and acceptable for mothers of ADHD children. None. Clinical Trial Registration-URL: http://www.irct.ir. Unique identifier: IRCT201111288234N1.

  20. The effect of increasing strength and approach velocity on triple jump performance.

    Science.gov (United States)

    Allen, Sam J; Yeadon, M R Fred; King, Mark A

    2016-12-08

    The triple jump is an athletic event comprising three phases in which the optimal phase ratio (the proportion of each phase to the total distance jumped) is unknown. This study used a planar whole body torque-driven computer simulation model of the ground contact parts of all three phases of the triple jump to investigate the effect of strength and approach velocity on optimal performance. The strength and approach velocity of the simulation model were each increased by up to 30% in 10% increments from baseline data collected from a national standard triple jumper. Increasing strength always resulted in an increased overall jump distance. Increasing approach velocity also typically resulted in an increased overall jump distance but there was a point past which increasing approach velocity without increasing strength did not lead to an increase in overall jump distance. Increasing both strength and approach velocity by 10%, 20%, and 30% led to roughly equivalent increases in overall jump distances. Distances ranged from 14.05m with baseline strength and approach velocity, up to 18.49m with 30% increases in both. Optimal phase ratios were either hop-dominated or balanced, and typically became more balanced when the strength of the model was increased by a greater percentage than its approach velocity. The range of triple jump distances that resulted from the optimisation process suggests that strength and approach velocity are of great importance for triple jump performance. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. The efficacy of betulinic acid in triple-negative breast cancer

    Directory of Open Access Journals (Sweden)

    Daniel Weber

    2014-09-01

    Full Text Available Purpose: The treatment of triple-negative breast cancer remains a daunting challenge with the standard-of-care treatments eventually failing due to acquired drug resistance, toxic side effects and the presence of a deregulated immune response. New treatments for overcoming these drawbacks include the use of plant extracts. Study design: In this study, the efficacy of betulinic acid, a naturally abundant phytochemical exhibiting anti-inflammatory and anti-proliferative activity, has been evaluated for the treatment of triple-negative breast cancer MDA-MB-231 and MDA-MB-468 cell lines. Furthermore, the ability of betulinic acid to inhibit angiogenesis was also determined. Results: Here, we report that betulinic acid was able to inhibit the inflammatory response, inhibit angiogenesis and cause cell cycle arrest ultimately causing apoptosis in triple-negative breast cancer cells. Our findings support that the identification of naturally occurring anti-tumour compounds may provide a chemotherapeutic approach for the treatment of triple-negative breast cancer. Conclusion: Overall, our results provide a molecular basis for the ability of betulinic acid to mediate apoptosis, suppress inflammation and inhibit angiogenesis in triple-negative breast cancer cell lines.

  2. Studies of the Triple PomeronVertex in perturbative QCD and its applications in phenomenology

    Energy Technology Data Exchange (ETDEWEB)

    Kutak, K.

    2006-12-15

    We study the properties of the Triple Pomeron Vertex in the perturbative QCD using the twist expansion method. Such analysis allows us to find the momenta configurations preferred by the vertex. When the momentum transfer is zero, the dominant contribution in the limit when N{sub c}{yields}{infinity} comes from anticollinear pole. This is in agreement with result obtained without expanding, but by direct averaging of the Triple Pomeron Vertex over angles. Resulting theta functions show that the anticollinear configuration is optimal for the vertex. In the finite N{sub c} case the collinear term also contributes. Using the Triple Pomeron Vertex we construct a pomeron loop and we also consider four gluon propagation between two Triple Pomeron Vertices. We apply the Triple Pomeron Vertex to construct the Hamiltonian from which we derive the Balitsky-Kovchegov equation for an unintegrated gluon density. In order to apply this equation to phenomenology, we apply the Kwiecinski-Martin-Stasto model for higher order corrections to a linear part of the Balitsky-Kovchegov equation. We introduce the definition of the saturation scale which reflects properties of this equation. Finally, we use it for computation of observables, such as the F{sub 2} structure function and diffractive Higgs boson production cross section. The impact of screening corrections on F{sub 2} is negligible, but those effects turn out to be significant for diffractive Higgs boson production at LHC.

  3. The Fluid Foil: The Seventh Simple Machine

    Science.gov (United States)

    Mitts, Charles R.

    2012-01-01

    A simple machine does one of two things: create a mechanical advantage (lever) or change the direction of an applied force (pulley). Fluid foils are unique among simple machines because they not only change the direction of an applied force (wheel and axle); they convert fluid energy into mechanical energy (wind and Kaplan turbines) or vice versa,…

  4. Simple utility functions with Giffen demand

    DEFF Research Database (Denmark)

    Sørensen, Peter Norman

    2007-01-01

    Simple utility functions with the Giffen property are presented: locally, the demand curve for a good is upward sloping. The utility functions represent continuous, monotone, convex preferences......Simple utility functions with the Giffen property are presented: locally, the demand curve for a good is upward sloping. The utility functions represent continuous, monotone, convex preferences...

  5. Sunspots and Their Simple Harmonic Motion

    Science.gov (United States)

    Ribeiro, C. I.

    2013-01-01

    In this paper an example of a simple harmonic motion, the apparent motion of sunspots due to the Sun's rotation, is described, which can be used to teach this subject to high-school students. Using real images of the Sun, students can calculate the star's rotation period with the simple harmonic motion mathematical expression.

  6. Simple Numerical Analysis of Longboard Speedometer Data

    Science.gov (United States)

    Hare, Jonathan

    2013-01-01

    Simple numerical data analysis is described, using a standard spreadsheet program, to determine distance, velocity (speed) and acceleration from voltage data generated by a skateboard/longboard speedometer (Hare 2012 "Phys. Educ." 47 409-17). This simple analysis is an introduction to data processing including scaling data as well as…

  7. The world's biomes and primary production as a triple tragedy of the commons foraging game played among plants.

    Science.gov (United States)

    McNickle, Gordon G; Gonzalez-Meler, Miquel A; Lynch, Douglas J; Baltzer, Jennifer L; Brown, Joel S

    2016-11-16

    Plants appear to produce an excess of leaves, stems and roots beyond what would provide the most efficient harvest of available resources. One way to understand this overproduction of tissues is that excess tissue production provides a competitive advantage. Game theoretic models predict overproduction of all tissues compared with non-game theoretic models because they explicitly account for this indirect competitive benefit. Here, we present a simple game theoretic model of plants simultaneously competing to harvest carbon and nitrogen. In the model, a plant's fitness is influenced by its own leaf, stem and root production, and the tissue production of others, which produces a triple tragedy of the commons. Our model predicts (i) absolute net primary production when compared with two independent global datasets; (ii) the allocation relationships to leaf, stem and root tissues in one dataset; (iii) the global distribution of biome types and the plant functional types found within each biome; and (iv) ecosystem responses to nitrogen or carbon fertilization. Our game theoretic approach removes the need to define allocation or vegetation type a priori but instead lets these emerge from the model as evolutionarily stable strategies. We believe this to be the simplest possible model that can describe plant production. © 2016 The Author(s).

  8. Evaluation of the existing triple point path models with new experimental data: proposal of an original empirical formulation

    Science.gov (United States)

    Boutillier, J.; Ehrhardt, L.; De Mezzo, S.; Deck, C.; Magnan, P.; Naz, P.; Willinger, R.

    2017-08-01

    With the increasing use of improvised explosive devices (IEDs), the need for better mitigation, either for building integrity or for personal security, increases in importance. Before focusing on the interaction of the shock wave with a target and the potential associated damage, knowledge must be acquired regarding the nature of the blast threat, i.e., the pressure-time history. This requirement motivates gaining further insight into the triple point (TP) path, in order to know precisely which regime the target will encounter (simple reflection or Mach reflection). Within this context, the purpose of this study is to evaluate three existing TP path empirical models, which in turn are used in other empirical models for the determination of the pressure profile. These three TP models are the empirical function of Kinney, the Unified Facilities Criteria (UFC) curves, and the model of the Natural Resources Defense Council (NRDC). As discrepancies are observed between these models, new experimental data were obtained to test their reliability and a new promising formulation is proposed for scaled heights of burst ranging from 24.6-172.9 cm/kg^{1/3}.

  9. Triple Quadrupole Versus High Resolution Quadrupole-Time-of-Flight Mass Spectrometry for Quantitative LC-MS/MS Analysis of 25-Hydroxyvitamin D in Human Serum

    Science.gov (United States)

    Geib, Timon; Sleno, Lekha; Hall, Rabea A.; Stokes, Caroline S.; Volmer, Dietrich A.

    2016-08-01

    We describe a systematic comparison of high and low resolution LC-MS/MS assays for quantification of 25-hydroxyvitamin D3 in human serum. Identical sample preparation, chromatography separations, electrospray ionization sources, precursor ion selection, and ion activation were used; the two assays differed only in the implemented final mass analyzer stage; viz. high resolution quadrupole-quadrupole-time-of-flight (QqTOF) versus low resolution triple quadrupole instruments. The results were assessed against measured concentration levels from a routine clinical chemiluminescence immunoassay. Isobaric interferences prevented the simple use of TOF-MS spectra for extraction of accurate masses and necessitated the application of collision-induced dissociation on the QqTOF platform. The two mass spectrometry assays provided very similar analytical figures of merit, reflecting the lack of relevant isobaric interferences in the MS/MS domain, and were successfully applied to determine the levels of 25-hydroxyvitamin D for patients with chronic liver disease.

  10. FPA-FTIR Microspectroscopy for Monitoring Chemotherapy Efficacy in Triple-Negative Breast Cancer

    Science.gov (United States)

    Zawlik, Izabela; Kaznowska, Ewa; Cebulski, Jozef; Kolodziej, Magdalena; Depciuch, Joanna; Vongsvivut, Jitraporn; Cholewa, Marian

    2016-11-01

    Triple-negative breast cancer is the most aggressive breast cancer subtype with limited treatment options and a poor prognosis. Approximately 70% of triple-negative breast cancer patients fail to achieve a pathologic complete response (pCR) after chemotherapy due to the lack of targeted therapies for this subtype. We report here the development of a focal-plane-array Fourier transform infrared (FPA-FTIR) microspectroscopic technique combined with principal component analysis (PCA) for monitoring chemotherapy effects in triple-negative breast cancer patients. The PCA results obtained using the FPA-FTIR spectral data collected from the same patients before and after the chemotherapy revealed discriminatory features that were consistent with the pathologic and clinical responses to chemotherapy, indicating the potential of the technique as a monitoring tool for observing chemotherapy efficacy.

  11. Death and Transfiguration of a Triple Junction in the South Atlantic

    Science.gov (United States)

    Ligi; Bonatti; Bortoluzzi; Carrara; Fabretti; Penitenti; Gilod; Peyve; Skolotnev; Turko

    1997-04-11

    Three major lithospheric plates-Antarctic, South American, and African-meet in the South Atlantic near Bouvet Island where the Mid-Atlantic Ridge (MAR), the Southwest Indian Ridge (SWIR), and the American Antarctic Ridge converge toward a fast evolving triple junction. A major magmatic pulse has recently built a new, swollen segment of the SWIR (Spiess Ridge) that is propagating toward the MAR at a rate of 4 to 5 centimeters per year, disrupting a former ridge-ridge-ridge (RRR) triple junction. A new triple junction will be established about 70 kilometers to the north when the propagating SWIR/Spiess segment will impact with the MAR, probably within the next 1 million years. The American Antarctic Ridge will take advantage of the MAR/SWIR duel by capturing an approximately 70-kilometer stretch of MAR, whereas the Antarctic plate will increase its size.

  12. [Combining mastopexy and triple-plane breast augmentation in correction of breast atrophy and ptosis].

    Science.gov (United States)

    Long, Xiao; Wang, Yang; Bai, Ming; Zhao, Ru

    2015-01-01

    To investigate the application of combining mastopexy and triple-plane breast augmentation in correction of breast ptosis and atrophy. Peri-areolar incision was performed to finish the fascia and dermal suspension to correct the breast ptosis. The implant was inserted under the pectoralis major muscle through lateral lower border of the gland and a "X" shape full thickness incision was made on the pectoralis major muscle according to the new position of nipple-areolar complex. 14 patients received combined mastopexy and triple-plane breast augmentation to correct breast atrophy and mastopexy simultaneously. All the patients were regularly followed for 6-12 months. No patients suffered severe complication and the results were satisfied. "Triple-plane" breast augmentation could be safely performed with peri-areolar mastopexy with minor injury. The technique could help to ensure the balance between the gland, nipple-areolar complex and the implant.

  13. Does the triple P-Positive Parenting Program provide value for money?

    Science.gov (United States)

    Mihalopoulos, Cathrine; Sanders, Matthew R; Turner, Karen M T; Murphy-Brennan, Majella; Carter, Rob

    2007-03-01

    The aim of the present study was to investigate the economic case for the implementation of the Triple P-Positive Parenting Program on a population basis in Queensland, Australia, in order to reduce the prevalence of conduct disorder in children. Threshold analysis was undertaken together with a limited cost-effectiveness analysis. The Triple P-Positive Parenting Program is a dominant intervention; that is, it costs less than the amount it saves, until the reduction in prevalence falls below 7% where net costs become positive. Triple P is likely to be a worthwhile use of limited health funds. The economic case is promising, but further research is required to confirm the study results.

  14. Population-based prevention of child maltreatment: the U.S. Triple p system population trial.

    Science.gov (United States)

    Prinz, Ronald J; Sanders, Matthew R; Shapiro, Cheri J; Whitaker, Daniel J; Lutzker, John R

    2009-03-01

    The prevention of child maltreatment necessitates a public health approach. In the U.S. Triple P System Population Trial, 18 counties were randomly assigned to either dissemination of the Triple P-Positive Parenting Program system or to the services-as-usual control condition. Dissemination involved Triple P professional training for the existing workforce (over 600 service providers), as well as universal media and communication strategies. Large effect sizes were found for three independently derived population indicators: substantiated child maltreatment, child out-of-home placements, and child maltreatment injuries. This study is the first to randomize geographical areas and show preventive impact on child maltreatment at a population level using evidence-based parenting interventions.

  15. How To Design A Triple Bottom Line Organization: A Start-Up Case Study

    Directory of Open Access Journals (Sweden)

    Bernhard Schroeder

    2014-05-01

    Full Text Available In today’s business environment, where success for a start-up company is measured by early revenue and profit, it can be quite challenging to design a triple bottom line organization (people/planet/profit from the very beginning. We present a case study of a U.S.-based start-up firm and discuss its early challenges, developmental processes, and current success as a triple bottom line firm. The company’s founder and CEO, with no initial product, distribution, or revenue strategy, sought to develop a company that could provide the marketplace with a valuable product while also staying true to a corporate vision of positively affecting less fortunate people. Our analysis of the case suggests that the founder’s vision, passion, transparent communication, and leveraging of partners’ resources were key elements in building the firm. We draw implications of our case study for the designers of future triple bottom line organizations.

  16. In silico modeling of the rheological properties of covalently crosslinked collagen triple helices

    CERN Document Server

    Head, David A; Russell, Stephen J; Wood, David J

    2016-01-01

    Biomimetic hydrogels based on natural polymers are a promising class of biomaterial, mimicking the natural extra-cellular matrix of biological tissues and providing cues for cell attachment, proliferation and differentiation. With a view to providing an upstream method to guide subsequent experimental design, the aim of this study was to introduce a mathematical model that described the rheological properties of a hydrogel system based on covalently crosslinked collagen triple helices. In light of their organization, such gels exhibit limited collagen bundling that cannot be described by existing fibril network models. The model presented here treats collagen triple helices as discrete semi-flexible polymers, permits full access to metrics for network microstructure, and should provide a comprehensive understanding of the parameter space associated with the development of such multi-functional materials. Triple helical hydrogel networks were experimentally obtained via reaction of type I collagen with both ar...

  17. Determining safe antibiotics for drug hypersensitive patients with the alternative method of double-triple test.

    Science.gov (United States)

    Karakaya, G; Isik, S R; Kalyoncu, A F

    2008-01-01

    Allergic reactions to antibiotics are common in daily clinical allergy practice. Oral drug provocation tests (ODPT) are used to determine safe alternative antibiotics in addition to diagnostic purposes. In one of our previous studies, we have shown that triple test was a safe, time-saving and cost-effective method for determining safe alternatives for patients with non-steroidal anti-inflammatory drug (NSAID) hypersensitivity. Our aim was to investigate the safety of one day two or three antibiotic ODPT performed to find safe alternative antibiotics in antibiotic/NSAID hypersensitive patients, as a cost effective and time saving alternative to conventional one day one antibiotic ODPT. Fifty-three patients were enrolled into this survey between 1 September 2005 and 31 December 2006. Double and triple tests are defined as performing ODPT with two and three antibiotics consecutively on the same day. Mean age of the patients was 41.3 +/- 11.7 years and 71.7 % were females. Beta-lactams (41.5 %) were the antibiotics most commonly causing reactions and the most common reaction was urticaria (68.8 %). Double test was performed in 26 (ciprofloxacin + clarithromycin, ciprofloxacin + tetracyline, clarithromycin + tetracycline, ciprofloxacin + ampicillin and ciprofloxacin + roxithromycin) and triple test in 27 patients (ciprofloxacin + tetracycline + clarithromycin, ciprofloxacin + tetracycline + ampicillin, clarithromycin + tetracycline + clindamycin and clarithromycin + ciprofloxacin + ampicillin). Only four patients had positive reactions during triple and double tests. There were no serious adverse reactions. Sixty-five days have been spent with triple-double tests where it would be 136 days with the conventional method. The triple-double ODPT performed with antibiotics in antibiotic/NSAID hypersensitive patients with the purpose of determining a safe alternative antibiotic could be a safe, cost-effective and time-saving alternative to conventional one day one antibiotic

  18. Rheumatoid Arthritis Treatment After Methotrexate: The Durability of Triple Therapy Versus Etanercept.

    Science.gov (United States)

    Peper, Shana M; Lew, Robert; Mikuls, Ted; Brophy, Mary; Rybin, Denis; Wu, Hongseng; O'Dell, James

    2017-10-01

    Although it is common for rheumatologists to initiate biologic agents after failure of methotrexate monotherapy in rheumatoid arthritis (RA), ample data support the initial use of combinations of conventional therapies in this clinical scenario. Our study explores the durability of triple therapy (methotrexate, sulfasalazine, and hydroxychloroquine) versus methotrexate-etanercept in RA. RA patients with suboptimal response to methotrexate (n = 353) were randomized to either triple therapy or methotrexate-etanercept therapy in a 48-week, double-blinded, noninferiority trial. Patients without clinical improvement at 24 weeks were switched to the alternative treatment. Of the total, 289 participated in followup. We report treatment durability, Disease Activity Score in 28 joints (DAS28), and other measures during an open-label extension for an additional period up to 72 weeks. Mean ± SD duration of open-label followup was 11 ± 6 months. The likelihood of continuing conventional therapy at 1 year was 78% for triple therapy versus 63% for methotrexate-etanercept, with most treatment changes occurring at the start of followup. More patients changed from methotrexate-etanercept to triple therapy than from triple therapy to methotrexate-etanercept (P = 0.005). DAS28 scores and other disease activity measures were not different for the 2 treatments and were stable during followup. In RA patients with suboptimal methotrexate response randomized to receive triple therapy or methotrexate-etanercept, the former was found to be significantly more durable. Given cost differences and similar outcomes, the variable durability demonstrated provides additional evidence supporting conventional combinations over biologic agent combinations as the first choice after methotrexate inadequate response. © 2017, American College of Rheumatology.

  19. Gender differences in triple jump phase ratios and arm swing motion of international level athletes

    Directory of Open Access Journals (Sweden)

    Vassilios Panoutsakopoulos

    2016-12-01

    Full Text Available Background: Female triple jumping is a relatively new athletics event. A limited number of researchers have focused on comparing male and female jumpers competing in international events, resulting in scarce findings in the literature regarding gender differences of the determinants of triple jump performance. Objective: The aim of the study was to examine the possible gender differences in the approach step characteristics, the spatiotemporal parameters of the separate phases of the triple jump as performed by athletes participating in sub-elite international events. Methods: The male and female participants of the 2015 European Team Championships triple jump event were recorded with a panning video camera. Approach speed was measured using photocells. Kinematical parameters were extracted using the APAS WIZARD 13.3.0.3 software. The relationships between the examined parameters and the actual triple jump performance were examined with Pearson's correlation analysis. Repeated measures ANOVA and chi-square statistical tests were run to examine the significance of the differences between genders. Results: Approach speed significantly correlated with the actual jumping distance in both males and females (p < .05. Significant gender differences (p < .05 existed concerning basic kinematical parameters. Men were found to have larger average horizontal speed of the 11 m to 1 m segment of the final approach, step length of the final six steps of the approach, step frequency of the final two steps, actual phase distances and percentage distribution of the step. Women, unlike men, used solely single arm swing techniques. No athlete executed the jump using a jump dominated technique. Conclusions: Gender differences in triple jump performance lies upon the kinematical parameters of the final two steps of the approach, the length of the step phase and the support time for the jump. The technique elements of the penultimate step are suggested to

  20. Evaluate Risk/Benefit of Nab Paclitaxel in Combination With Gemcitabine and Carboplatin Compared to Gemcitabine and Carboplatin in Triple Negative Metastatic Breast Cancer (or Metastatic Triple Negative Breast Cancer)

    Science.gov (United States)

    2017-06-05

    Breast Tumor; Breast Cancer; Cancer of the Breast; Estrogen Receptor- Negative Breast Cancer; HER2- Negative Breast Cancer; Progesterone Receptor- Negative Breast Cancer; Recurrent Breast Cancer; Stage IV Breast Cancer; Triple-negative Breast Cancer; Triple-negative Metastatic Breast Cancer; Metastatic Breast Cancer

  1. Physics of lateral triple quantum-dot molecules with controlled electron numbers.

    Science.gov (United States)

    Hsieh, Chang-Yu; Shim, Yun-Pil; Korkusinski, Marek; Hawrylak, Pawel

    2012-11-01

    We review the recent progress in theory and experiments with lateral triple quantum dots with controlled electron numbers down to one electron in each dot. The theory covers electronic and spin properties as a function of topology, number of electrons, gate voltage and external magnetic field. The orbital Hund's rules and Nagaoka ferromagnetism, magnetic frustration and chirality, interplay of quantum interference and electron-electron interactions and geometrical phases are described and related to charging and transport spectroscopy. Fabrication techniques and recent experiments are covered, as well as potential applications of triple quantum-dot molecule in coherent control, spin manipulation and quantum computation.

  2. Modeling Radiation Effects on a Triple Junction Solar Cell using Silvaco ATLAS

    OpenAIRE

    Schiavo, Daniel

    2012-01-01

    In this research, Silvaco ATLAS, an advanced virtual wafer fabrication tool, was used to model the effects of radiation on a triple junction InGaP/GaAs/Ge solar cell. A Silvaco ATLAS model of a triple junction InGaP/GaAs/Ge cell was created by first creating individual models for solar cells composed of each material. Realistic doping levels were used and thicknesses were varied to produce the design parameters and create reasonably efficient solar cell models for testing. After the individua...

  3. Telehealth and Occupational Therapy: Integral to the Triple Aim of Health Care Reform.

    Science.gov (United States)

    Cason, Jana

    2015-01-01

    Programs and concepts included in the Patient Protection and Affordable Care Act of 2010 are expected to transform health care in the United States from a volume-based health system to a value-based health system with increased emphasis on prevention and health promotion. The Triple Aim, a framework set forth by the Institute for Healthcare Improvement, focuses on improving the health care experience, the health of populations, and the affordability of care. This article describes telehealth as an integral component in achieving the Triple Aim of health care and discusses implications for occupational therapy practitioners. Copyright © 2015 by the American Occupational Therapy Association, Inc.

  4. A Modified Triple Pelvic Osteotomy for the Treatment of Hip Hypoplasia

    Directory of Open Access Journals (Sweden)

    Hassan Rahimi

    2013-09-01

    Full Text Available Background: The prevalence of hip dysplasia is 1 in 1000. Several pelvic osteotomy methods have been developed to prevent early osteoarthritis, such as triple osteotomy. In this study we are going to introduce our new technique that was done on 4 patients with favorable short-term results.   Methods: Four patients underwent triple osteotomy and fixation using a reconstruction plate and early weight bearing was started. Results: The Harris Hip Score, limb length, center-edge angle, and acetabular inclination showed improvement. Conclusion: This modified technique is suggested for corrective surgery on adult dysplastic hips.

  5. A novel High-Voltage System for a triple GEM detector

    CERN Document Server

    Corradi, Giovanni; Tagnani, Diego; 10.1016/j.nima.2006.10.166

    2007-01-01

    A novel High-Voltage System for a triple GEM detector has been designed and realized in Frascati within the LHCb muon detector framework. The system is built with seven floating power supply, with a maximum of 1200 V each, and controlled via CANbus, for voltage settings and monitoring. Several HV modules can be installed in a nano-ammeter mainframe already developed in Frascati, realizing a HV crate able to supply up to 24 triple GEM chambers with a 1 nA resolution monitoring system.

  6. TripleR: an R package for social relations analyses based on round-robin designs.

    Science.gov (United States)

    Schönbrodt, Felix D; Back, Mitja D; Schmukle, Stefan C

    2012-06-01

    In this article, we present TripleR, an R package for the calculation of social relations analyses (Kenny, 1994) based on round-robin designs. The scope of existing software solutions is ported to R and enhanced with previously unimplemented methods of significance testing in single groups (Lashley & Bond, 1997) and handling of missing values. The package requires only minimal knowledge of R, and results can be exported for subsequent analyses to other software packages. We demonstrate the use of TripleR with several didactic examples.

  7. Phantom studies of triple photon absorptiometry and bone mineral measurement at a hip prosthesis

    Energy Technology Data Exchange (ETDEWEB)

    Farrell, T.J.; Webber, C.E. (Chedoke McMaster Hospitals, Hamilton, ON (Canada). Dept. of Nuclear Medicine)

    1992-03-01

    The feasibility of using triple photon absorptiometry (TPA) for the measurement of bone mineral mass about a hip prosthesis was examined. A theoretical expression describing the variance of TPA measurements was verified using a triple photon source and phantom materials which simulate the soft tissue-bone mineral-metal prosthesis system. The expression for the variance was used to determine an optimized set of photon energies. It was shown that a precision of 3% could be obtained for reasonable measurement times using this optimized set of energies and that TPA should be a feasible approach for measurement of bone mineral about a hip prosthesis. (orig.).

  8. Triple phase boundary specific pathway analysis for quantitative characterization of solid oxide cell electrode microstructure

    DEFF Research Database (Denmark)

    Jørgensen, Peter Stanley; Ebbehøj, Søren Lyng; Hauch, Anne

    2015-01-01

    The density and percolation of Triple phase boundary sites are important quantities in analyzing microstructures of solid oxide fuel cell electrodes from tomography data. However, these measures do not provide descriptions of the quality of the TPB sites in terms of the length and radius of the p......The density and percolation of Triple phase boundary sites are important quantities in analyzing microstructures of solid oxide fuel cell electrodes from tomography data. However, these measures do not provide descriptions of the quality of the TPB sites in terms of the length and radius...

  9. FULFIL Trial: Once-Daily Triple Therapy for Patients with Chronic Obstructive Pulmonary Disease.

    Science.gov (United States)

    Lipson, David A; Barnacle, Helen; Birk, Ruby; Brealey, Noushin; Locantore, Nicholas; Lomas, David A; Ludwig-Sengpiel, Andrea; Mohindra, Rajat; Tabberer, Maggie; Zhu, Chang-Qing; Pascoe, Steven J

    2017-08-15

    Randomized data comparing triple therapy with dual inhaled corticosteroid (ICS)/long-acting β 2 -agonist (LABA) therapy in patients with chronic obstructive pulmonary disease (COPD) are limited. We compared the effects of once-daily triple therapy on lung function and health-related quality of life with twice-daily ICS/LABA therapy in patients with COPD. The FULFIL (Lung Function and Quality of Life Assessment in Chronic Obstructive Pulmonary Disease with Closed Triple Therapy) trial was a randomized, double-blind, double-dummy study comparing 24 weeks of once-daily triple therapy (fluticasone furoate/umeclidinium/vilanterol 100 μg/62.5 μg/25 μg; ELLIPTA inhaler) with twice-daily ICS/LABA therapy (budesonide/formoterol 400 μg/12 μg; Turbuhaler). A patient subgroup remained on blinded treatment for up to 52 weeks. Co-primary endpoints were change from baseline in trough FEV 1 and in St. George's Respiratory Questionnaire (SGRQ) total score at Week 24. In the intent-to-treat population (n = 1,810) at Week 24 for triple therapy (n = 911) and ICS/LABA therapy (n = 899), mean changes from baseline in FEV 1 were 142 ml (95% confidence interval [CI], 126 to 158) and -29 ml (95% CI, -46 to -13), respectively, and mean changes from baseline in SGRQ scores were -6.6 units (95% CI, -7.4 to -5.7) and -4.3 units (95% CI, -5.2 to -3.4), respectively. For both endpoints, the between-group differences were statistically significant (P < 0.001). There was a statistically significant reduction in moderate/severe exacerbation rate with triple therapy versus dual ICS/LABA therapy (35% reduction; 95% CI, 14-51; P = 0.002). The safety profile of triple therapy reflected the known profiles of the components. These results support the benefits of single-inhaler triple therapy compared with ICS/LABA therapy in patients with advanced COPD. Clinical trial registered with www.clinicaltrials.gov (NCT02345161).

  10. Equivariant spectral triples for $SU_q(\\ell+1)$ and the odd dimensional quantum spheres

    OpenAIRE

    Chakraborty, Partha Sarathi; Pal, Arupkumar

    2005-01-01

    We formulate the notion of equivariance of an operator with respect to a covariant representation of a C^*-dynamical system. We then use a combinatorial technique used by the authors earlier in characterizing spectral triples for SU_q(2) to investigate equivariant spectral triples for two classes of spaces: the quantum groups SU_q(\\ell+1) for \\ell>1, and the odd dimensional quantum spheres S_q^{2\\ell+1} of Vaksman & Soibelman. In the former case, a precise characterization of the sign and the...

  11. Torus equivariant spectral triples for odd dimensional quantum spheres coming from $C^*$-extensions

    OpenAIRE

    Chakraborty, Partha Sarathi; Pal, Arupkumar

    2007-01-01

    The torus group $(S^1)^{\\ell+1}$ has a canonical action on the odd dimensional sphere $S_q^{2\\ell+1}$. We take the natural Hilbert space representation where this action is implemented and characterize all odd spectral triples acting on that space and equivariant with respect to that action. This characterization gives a construction of an optimum family of equivariant spectral triples having nontrivial $K$-homology class thus generalizing our earlier results for $SU_q(2)$. We also relate the...

  12. Triple antiplatelet therapy for preventing vascular events: a systematic review and meta-analysis

    Directory of Open Access Journals (Sweden)

    Bath Philip MW

    2010-06-01

    Full Text Available Abstract Background Dual antiplatelet therapy is usually superior to mono therapy in preventing recurrent vascular events (VEs. This systematic review assesses the safety and efficacy of triple antiplatelet therapy in comparison with dual therapy in reducing recurrent vascular events. Methods Completed randomized controlled trials investigating the effect of triple versus dual antiplatelet therapy in patients with ischaemic heart disease (IHD, cerebrovascular disease or peripheral vascular disease were identified using electronic bibliographic searches. Data were extracted on composite VEs, myocardial infarction (MI, stroke, death and bleeding and analysed with Cochrane Review Manager software. Odds ratios (OR and 95% confidence intervals (CI were calculated using random effects models. Results Twenty-five completed randomized trials (17,383 patients with IHD were included which involving the use of intravenous (iv GP IIb/IIIa inhibitors (abciximab, eptifibatide, tirofiban, aspirin, clopidogrel and/or cilostazol. In comparison with aspirin-based therapy, triple therapy using an intravenous GP IIb/IIIa inhibitor significantly reduced composite VEs and MI in patients with non-ST elevation acute coronary syndromes (NSTE-ACS (VE: OR 0.69, 95% CI 0.55-0.86; MI: OR 0.70, 95% CI 0.56-0.88 and ST elevation myocardial infarction (STEMI (VE: OR 0.39, 95% CI 0.30-0.51; MI: OR 0.26, 95% CI 0.17-0.38. A significant reduction in death was also noted in STEMI patients treated with GP IIb/IIIa based triple therapy (OR 0.69, 95% CI 0.49-0.99. Increased minor bleeding was noted in STEMI and elective percutaneous coronary intervention (PCI patients treated with GP IIb/IIIa based triple therapy. Stroke events were too infrequent for us to be able to identify meaningful trends and no data were available for patients recruited into trials on the basis of stroke or peripheral vascular disease. Conclusions Triple antiplatelet therapy based on iv GPIIb/IIIa inhibitors

  13. The value of recognizing suspect diagnoses in the triple diagnosis of giant cell tumor of bone

    Directory of Open Access Journals (Sweden)

    Kotru Mrinalini

    2007-01-01

    Full Text Available Giant cell tumor (GCT of bone is the most frequently over-diagnosed neoplasm in orthopedic pathology because giant cells are a common component of many neoplastic and nonneoplastic conditions of bone. Triple diagnosis, requiring substantial individual and collective inputs by orthopedic surgeons, radiologists and pathologists, is the preferred method for the workup of patients with suspected bone neoplasms. At each stage in triple diagnosis, deviations from the typical must be regarded as clues to alternate diagnoses: the greater the deviation, the more a diagnosis of GCT must be considered suspect. A suspect diagnosis must trigger renewed analysis of the available data and a diligent search to exclude alternate diagnoses.

  14. Triple oxygen isotope composition of the Campi Flegrei magma systems

    Science.gov (United States)

    Iovine, Raffaella Silvia; Wörner, Gerhard; Pack, Andreas; Sengupta, Sukanya; Carmine Mazzeo, Fabio; Arienzo, Ilenia; D'Antonio, Massimo

    2017-04-01

    Sr-O isotope relationships in igneous rocks are a powerful tool to distinguish magma sources and quantify assimilation processes in magmatic rocks. Isotopic (87Sr/86Sr and 18O/16O-17O/16O) data have been acquired on whole rocks and separated minerals (feldspar, Fe-cpx, Mg-cpx, olivine phenocrysts) from pyroclastic products of the Campi Flegrei volcanic complex (Gulf of Naples, Southern Italy). Oxygen isotope ratios were measured by infrared laser fluorination using a Thermo MAT253 gas source isotope ratio mass spectrometer in dual inlet mode, on ˜2 mg of hand-picked phenocrysts. Variations in triple oxygen isotope ratios (17O/16O, 18O/16O) are expressed as the δ notation relative to VSMOW. Sr isotopic compositions were determined by thermal ionization mass spectrometry after standard cation-exchange methods on separated hand-picked phenocrysts (˜300 mg), and on whole rocks, in case of insufficient sample size to separate crystals. Sr-isotopes in Campi Flegrei minerals range from 0.707305 to 0.707605 and δ18O varies from 6.5 to 8.3‰ . Recalculated δ18Omelt values accordingly show a large range between 7.2 and 8.6‰ . Our data, compared with published δ18O-isotope data from other Italian volcanic centers (Alban Hills, Mts. Ernici, Ischia, Mt. Vesuvius, Aeolian Islands, Tuscany and Sardinia) and from subduction zones worldwide (Kamchatka, Lesser Antilles, Indonesia and Central Andean ignimbrites), show compositions that are very different from typical mantle values. Distinct trends and sources are recognized in our compilation from global data: (1) serpentinized mantle (Kamchatka), (2) sediment-enrichment in the mantle source (Indonesia, Lesser Antilles, Eolian arc), (3) assimilation of old radiogenic continental crust affecting magmas derived from sediment-modified mantle sources (Tuscany, Sardinia), (4) assimilation of lower crustal lithologies (Central Andes, Alban Hills, Mts. Ernici, Ischia). Sr-O-isotope values of Campi Flegrei and Vesuvius magmas

  15. Oral Tranexamic Acid with Fluocinolone-Based Triple Combination Cream Versus Fluocinolone-Based Triple Combination Cream Alone in Melasma: An Open Labeled Randomized Comparative Trial.

    Science.gov (United States)

    Padhi, Tanmay; Pradhan, Swetalina

    2015-01-01

    Melasma is a common acquired cause of facial hyperpigmentation with no definitive therapy. Tranexamic acid, a plasmin inhibitor, has demonstrated depigmenting properties and combining this oral drug with other modalities of treatment has shown promising results. To compare the efficacy of a combination of oral tranexamic acid and fluocinolone-based triple combination cream with that of fluocinolone-based triple combination cream alone in melasma among Indian patients. 40 patients of melasma of either sex attending to dermatology OPD were enrolled in this study. Participants were randomly divided into two groups with 20 patients in each group. Group A patients were asked to apply the cream only and Group B patients received oral tranexamic acid 250 mg twice daily and applied a triple combination cream containing fluocinolone acetonide 0.01%, tretinoin 0.05%, and hydroquinone 2% once daily for 8 weeks. Response was evaluated using melasma area severity index (MASI) at baseline, 4 weeks, and 8 weeks. 40 patients completed the study. The MASI scores at baseline, 4 weeks and 8 weeks in group A were 15.425 + 1.09, 11.075 + 9.167 and 6.995 + 6.056 respectively and in group B 18.243 + 1.05, 6.135 + 4.94 and 2.19 + 3.38. Intergroup comparison showed a faster reduction in pigmentation in Group B as compared to Group A and the results were statistically significant at 4 weeks (P value 0.014) and 8 weeks (P value 0.000). The efficacy was maintained throughout the 6-month follow-up period. Addition of oral tranexamic acid to fluocinolone-based triple combination cream results in a faster and sustained improvement in the treatment of melasma.

  16. Oral tranexamic acid with fluocinolone-based triple combination cream versus fluocinolone-based triple combination cream alone in melasma: An open labeled randomized comparative trial

    Directory of Open Access Journals (Sweden)

    Tanmay Padhi

    2015-01-01

    Full Text Available Background : Melasma is a common acquired cause of facial hyperpigmentation with no definitive therapy. Tranexamic acid, a plasmin inhibitor, has demonstrated depigmenting properties and combining this oral drug with other modalities of treatment has shown promising results. Objectives : To compare the efficacy of a combination of oral tranexamic acid and fluocinolone-based triple combination cream with that of fluocinolone-based triple combination cream alone in melasma among Indian patients. Materials and Methods : 40 patients of melasma of either sex attending to dermatology OPD were enrolled in this study. Participants were randomly divided into two groups with 20 patients in each group. Group A patients were asked to apply the cream only and Group B patients received oral tranexamic acid 250 mg twice daily and applied a triple combination cream containing fluocinolone acetonide 0.01%, tretinoin 0.05%, and hydroquinone 2% once daily for 8 weeks. Response was evaluated using melasma area severity index (MASI at baseline, 4 weeks, and 8 weeks. Results : 40 patients completed the study. The MASI scores at baseline, 4 weeks and 8 weeks in group A were 15.425 + 1.09, 11.075 + 9.167 and 6.995 + 6.056 respectively and in group B 18.243 + 1.05, 6.135 + 4.94 and 2.19 + 3.38. Intergroup comparison showed a faster reduction in pigmentation in Group B as compared to Group A and the results were statistically significant at 4 weeks (P value 0.014 and 8 weeks (P value 0.000. The efficacy was maintained throughout the 6-month follow-up period. Conclusion: Addition of oral tranexamic acid to fluocinolone-based triple combination cream results in a faster and sustained improvement in the treatment of melasma.

  17. Simple bone cysts of two brothers

    Energy Technology Data Exchange (ETDEWEB)

    An, Seo Young; An, Chang Hyeon; Choi, Karp Shik [Department of Oral and Maxillofacial Radiology, School of Dentistry, Kyungpook National University, Daegu (Korea, Republic of)

    2008-09-15

    17-year-old and 14-year-old brothers were referred for evaluation of the cystic lesions on the mandibular anterior area with no symptoms. Neither their mother nor the brothers could recall any past trauma to those areas. Panoramic and intraoral radiographs revealed moderately defined cystic lesions on their mandibular anterior areas. Biopsies on both lesions revealed simple bone cysts. Hereditary cause or familial history of simple bone cysts could not be found in literature review. This case may have been a coincidence. However, further investigation is needed to find the cause of simple bone cysts occurring in patients those are closely related.

  18. Decomposing the Triple-Helix synergy into the regional innovation systems of Norway: Firm data and patent networks

    NARCIS (Netherlands)

    Strand, Ø.; Ivanova, I.; Leydesdorff, L.

    The Triple Helix model of university-industry-government relations allows us to use mutual information among geographical, sectorial, and size distribution of firms to measure synergy at various geographical scales in a nation. In this paper we decompose the synergy in Triple Helix relations and

  19. Laboratory investigation of triple marking the parasitoid Gonatocerus ashmeadi (Hymenoptera: Mymaridae) with a fluorescent dye and two animal proteins

    Science.gov (United States)

    Gonatocerus ashmeadi Girault, a parasitoid of Homalodisca vitripennis (Germar), was used as a model insect to investigate triple marking a minute hymenopteran for potential use for monitoring dispersal patterns of natural enemies in the field. The triple mark contained egg albumin in chicken eggs, c...

  20. Effectiveness of the Triple P Positive Parenting Program on behavioral problems in children: A meta-analysis

    NARCIS (Netherlands)

    de Graaf, I.; Speetjens, P.; Smit, F.; de Wolff, M.; Tavecchio, L.

    2008-01-01

    The Triple P Positive Parenting Program is a multilevel parenting program to prevent and offer treatment for severe behavioral, emotional, and developmental problems in children. The aim of this meta-analysis is to assess the effectiveness of Triple P Level 4 interventions in the management of

  1. Effectiveness of the Triple P Positive Parenting Program on Behavioral Problems in Children: A Meta-Analysis

    Science.gov (United States)

    de Graaf, Ireen; Speetjens, Paula; Smit, Filip; de Wolff, Marianne; Tavecchio, Louis

    2008-01-01

    The Triple P Positive Parenting Program is a multilevel parenting program to prevent and offer treatment for severe behavioral, emotional, and developmental problems in children. The aim of this meta-analysis is to assess the effectiveness of Triple P Level 4 interventions in the management of behavioral problems in children by pooling the…

  2. Abundance, composition and distribution of simple sequence ...

    Indian Academy of Sciences (India)

    Abundance, composition and distribution of simple sequence repeats and dinucleotide compositional bias within WSSV genomes. MALATHI SHEKAR, INDRANI KARUNASAGAR and IDDYA KARUNASAGAR*. Department of Fishery Microbiology, UNESCO Centre for Marine Biotechnology,. Karnataka Veterinary, Animal ...

  3. Thirty Simple Ideas for Interactive Whiteboards

    Science.gov (United States)

    Adams, Caralee

    2011-01-01

    This article presents thirty simple ideas for interactive whiteboards and how IWB can make one's teaching life easier. These teaching ideas for the interactive whiteboard can be used by teachers every day. Tips for classroom management are also presented.

  4. A Simple Preparation Method for Diphosphoimidazole

    DEFF Research Database (Denmark)

    Rosenberg, T.

    1964-01-01

    A simple method for the preparation of diphosphoimidazole is presented that involves direct phosphorylation of imidazole by phosphorus oxychloride in alkaline aqueous solution. Details are given on the use of diphosphoimidazole in preparing sodium phosphoramidate and certain phosphorylated amino...

  5. Evaluation of a modified "Triple-P" procedure in women with morbidly adherent placenta after previous caesarean section.

    Science.gov (United States)

    Wei, Yanxing; Cao, Yanwen; Yu, Yanhong; Wang, Zhijian

    2017-07-21

    To describe a modified "Triple-P" procedure and evaluate its outcome in women with morbidly adherent placenta (MAP) after previous caesarean section (CS). A retrospective cohort study of 96 women with MAP after CS was recruited with 45 women receiving the modified "Triple-P" procedure as study group and the other 51 cases receiving the conventional managements as the control. The maternal outcomes were compared. The modified "Triple-P" procedure was described in step by step. Women in study group demonstrated reduction of blood loss, transfusion blood volume and operation time, as well as less hospital days and lower hospitalization cost (P P > 0.05). Our modified "Triple-P" procedure for MAP after previous CS maintained the advantages of Chandraharan's "Triple-P" procedure in preservation of uterus for further fertility, less intraoperative blood loss, shorter hospital stays, and lower hospitalization cost but also advanced in feasibility and convenience during introducing into routine clinical practice.

  6. Erratum to: An Analysis of Training, Generalization, and Maintenance Effects of Primary Care Triple P for Parents of Preschool-Aged Children with Disruptive Behavior.

    Science.gov (United States)

    Boyle, Cynthia L; Sanders, Matthew R; Lutzker, John R; Prinz, Ronald J; Shapiro, Cheri; Whitaker, Daniel J

    2015-10-01

    The Triple P-Positive Parenting Program is owned by the University of Queensland (UQ). The University through its main technology transfer company UniQuest Pty Limited has licensed Triple P International Pty Ltd to disseminate the program worldwide. Royalties stemming from this dissemination activity are distributed to the Parenting and Family Support Centre, School of Psychology, UQ; Faculty of Health and Behavioural Sciences at UQ; and contributory authors. No author has any share or ownership in Triple P International Pty Ltd. Matthew Sanders is the founder and an author on various Triple P programs and a consultant to Triple P International. Karen Turner is an author of various Triple P programs. Ronald Prinz is a consultant to Triple P International. Cheri Shapiro is a consultant to Triple P America.

  7. Technical note: simple vibroacoustic foetal stimulator.

    Science.gov (United States)

    Stojanović, D; Frković, A; Filiplić-Stojanović, H; Kirincić, N

    2001-01-01

    To build and test a simple vibroacoustic foetal stimulator. A vibroacoustic foetal stimulator was constructed and subjected to bench testing. Clinical trial was carried out in comparison to an electro laynx. Screening specificity of 98% and 100% sensitivity was achieved, with no decrease in specificity due to user's maladjustments. The device was characterized by simple use, maintenance and disinfection. The device is a good screening instrument for foetal health in prenatal care, despite its simplicity and low price.

  8. Simple trophic modules for complex food webs

    OpenAIRE

    Bascompte, Jordi; Carlos J. Melián

    2005-01-01

    There are two common approaches to food webs. On the one hand, empirical studies have described aggregate statistical measures of many-species food webs. On the other hand, theoretical studies have explored the dynamic properties of simple tri-trophic food chains (i.e., trophic modules). The question remains to what extent results based on simple modules are relevant for whole food webs. Here we bridge between these two independent research agendas by exploring the relative fr...

  9. Online Multikernel Learning Based on a Triple-Norm Regularizer for Semantic Image Classification

    Directory of Open Access Journals (Sweden)

    Shuangping Huang

    2015-01-01

    Full Text Available Currently image classifiers based on multikernel learning (MKL mostly use batch approach, which is slow and difficult to scale up for large datasets. In the meantime, standard MKL model neglects the correlations among examples associated with a specific kernel, which makes it infeasible to adjust the kernel combination coefficients. To address these issues, a new and efficient multikernel multiclass algorithm called TripleReg-MKL is proposed in this work. Taking the principle of strong convex optimization into consideration, we propose a new triple-norm regularizer (TripleReg to constrain the empirical loss objective function, which exploits the correlations among examples to tune the kernel weights. It highlights the application of multivariate hinge loss and a conservative updating strategy to filter noisy samples, thereby reducing the model complexity. This novel MKL formulation is then solved in an online mode using a primal-dual framework. A theoretical analysis of the complexity and convergence of TripleReg-MKL is presented. It shows that the new algorithm has a complexity of OCMT and achieves a fast convergence rate of OlogT/T. Extensive experiments on four benchmark datasets demonstrate the effectiveness and robustness of this new approach.

  10. Enhancing the innovative capacity of small firms through triple helix interactions : challenges and opportunities

    NARCIS (Netherlands)

    Ranga, Liana Marina; Miedema, Joost; Jorna, Rene

    2008-01-01

    This paper presents the results of a recent exploratory study aiming to enhance the innovative capacity of small firms in the Northern Netherlands, a region lagging behind the rest of the country in terms of economic growth and innovative capacity. The triple helix perspective is adopted to examine

  11. The determinant bundle on the moduli space of stable triples over a ...

    Indian Academy of Sciences (India)

    We construct a holomorphic Hermitian line bundle over the moduli space of stable triples of the form (1, 2, ), where 1 and 2 are holomorphic vector bundles over a fixed compact Riemann surface , and : 2 → 1 is a holomorphic vector bundle homomorphism. The curvature of the Chern connection of this ...

  12. Scaling of triple differential cross-sections for asymmetric (e,2e ...

    Indian Academy of Sciences (India)

    Asymmetric (e, 2e) process; triple differential cross-section; scaling; helium ... initial state wave function is not exactly known and those in use do not have an ... Z dependence of the target wave function for (e, 2e) process. Consider the one- parameter variational wave function of helium ground state φi ( r1, r2) = (. Z 3 π ).

  13. Hydroxyproline Ring Pucker Causes Frustration of Helix Parameters in the Collagen Triple Helix

    Science.gov (United States)

    Ying Chow, W.; Bihan, Dominique; Forman, Chris J.; Slatter, David A.; Reid, David G.; Wales, David J.; Farndale, Richard W.; Duer, Melinda J.

    2015-07-01

    Collagens, the most abundant proteins in mammals, are defined by their triple-helical structures and distinctive Gly-Xaa-Yaa repeating sequence, where Xaa is often proline and Yaa, hydroxyproline (Hyp/O). It is known that hydroxyproline in the Yaa position stabilises the triple helix, and that lack of proline hydroxylation in vivo leads to dysfunctional collagen extracellular matrix assembly, due to a range of factors such as a change in hydration properties. In addition, we note that in model peptides, when Yaa is unmodified proline, the Xaa proline has a strong propensity to adopt an endo ring conformation, whilst when Yaa is hydroxyproline, the Xaa proline adopts a range of endo and exo conformations. Here we use a combination of solid-state NMR spectroscopy and potential energy landscape modelling of synthetic triple-helical collagen peptides to understand this effect. We show that hydroxylation of the Yaa proline causes the Xaa proline ring conformation to become metastable, which in turn confers flexibility on the triple helix.

  14. A Mid-Infrared Search for the Outer Companion in a Millisecond Pulsar Triple System [Dataset

    NARCIS (Netherlands)

    Kaplan, D.; Ransom, S.; Stairs, I.; Hessels, J.

    2012-01-01

    Only two systems with pulsars and multiple companions are known, but they offer a wealth of information about dynamics, binary evolution, and the pulsars themselves. We have recently discovered a bright new millisecond pulsar in a very exotic stellar system: a hierarchical triple system with a

  15. From Commodity Production to Sign Production: A Triple Triangle Model for Marx's Semiotics and Peirce's Economics.

    Science.gov (United States)

    Kim, Joohoan

    Using the viewpoint of semiotics, this paper "re-reads" Karl Marx's labor theory of value and suggests a "triple triangle" model for commodity production and shows how this model could be a model for semiosis in general. The paper argues that there are three advantages to considering homogeneity of the sign production and the…

  16. Open Innovation, Triple Helix and Regional Innovation Systems: Exploring CATAPULT Centres in the UK

    Science.gov (United States)

    Kerry, Christopher; Danson, Michael

    2016-01-01

    Through the lens of UK CATAPULT Centres this conceptual paper presents an examination of the links between open innovation, the Triple Helix model and regional innovation systems. Highlighting the importance of boundary-spanning intermediaries, the combined role of these concepts is explored in detail. A conceptual model is then proposed which…

  17. Preparation of Porous Hollow Fiber Membranes with a Triple-Orifice Spinneret

    NARCIS (Netherlands)

    He, T.; Mulder, M.H.V.; Wessling, Matthias

    2003-01-01

    A triple-orifice spinneret has been applied for the preparation of hollow fiber microfiltration membranes with a high surface porosity. Considering the general rules of diffusion induced phase separation, a low polymer concentration is required at the outer layer to obtain a highly interconnected

  18. Tailored versus Triple plus Bismuth or Concomitant Therapy as Initial Helicobacter pylori Treatment: A Randomized Trial.

    Science.gov (United States)

    Zhou, Liya; Zhang, Jianzhong; Song, Zhiqiang; He, Lihua; Li, Yanqing; Qian, Jiaming; Bai, Peng; Xue, Yan; Wang, Ye; Lin, Sanren

    2016-04-01

    With markedly increased antibiotic resistance and unsatisfactory efficacies of common empiric eradication regimens in the mainland of China, tailored therapy may be the best choice to achieve good efficacy. This study compared the eradication rates, safety, and compliance of tailored therapy to those of triple therapy plus bismuth and concomitant therapy in the naïve patients with Helicobacter pylori infection. Between September 2013 and April 2014, 1050 patients with H. pylori infection at three tertiary hospitals were randomly assigned to 10-day treatment with tailored, triple plus bismuth, or concomitant regimens. In tailored therapy, medications were adjusted according to clarithromycin sensitivity and cytochrome P450 isoenzyme 2C19 genotype. The antimicrobial susceptibility testing (E test) was performed. Eradication status was assessed 4-12 weeks after treatment. The eradication rate was significantly higher in tailored group than in triple plus bismuth and concomitant groups in both intention-to-treat (88.7 vs 77.4 vs 78.3%, p bismuth and 75.9, 87.2, 92.9, and 95.2% in concomitant therapy, respectively. First-line tailored therapy achieves significantly higher eradication rates and fewer side effects, compared to triple therapy plus bismuth and concomitant therapy in a setting with high rates of clarithromycin and metronidazole resistance. © 2015 John Wiley & Sons Ltd.

  19. A single drug for Helicobacter pylori infection: first results with a new bismuth triple monocapsule

    NARCIS (Netherlands)

    de Boer, W. A.; van Etten, R. J.; Schneeberger, P. M.; Tytgat, G. N.

    2000-01-01

    In this pilot study we investigated the efficacy and tolerability of a new monocapsule that contains a bismuth compound, tetracycline, and metronidazole. If proven to be effective, this monotherapy would turn the well-accepted multidrug regimen of standard bismuth-based triple therapy into an easy

  20. Role of bismuth in improving Helicobacter pylori eradication with triple therapy.

    Science.gov (United States)

    Dore, Maria Pina; Lu, Hong; Graham, David Y

    2016-05-01

    In most regions of the world, antimicrobial resistance has increased to the point where empirical standard triple therapy for Helicobacter pylorieradication is no longer recommended. The treatment outcome in a population is calculated as the sum of the treatment success in the subpopulation with susceptible infections plus treatment success in the subpopulation with resistant infections. The addition of bismuth (i.e., 14-day triple therapy plus bismuth) can improve cure rates despite a high prevalence of antimicrobial resistance. The major bismuth effect is to add an additional 30%-40% to the success with resistant infections. The overall result is therefore dependent on the prevalence of resistance and the treatment success in the subpopulation with resistant infections (eg, with proton-pump inhibitor-amoxicillin dual therapy). Here, we explore the contribution of each component and the mechanisms of how bismuth might enhance the effectiveness of triple therapy. We also discuss the limitations of this approach and provide suggestions how triple therapy plus bismuth might be further improved. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/