2008 Science Accomplishments Report of the Pacific Northwest Research Station

Science.gov (United States)

Rhonda Mazza

2009-01-01

This report highlights significant research findings and accomplishments by scientists at the Pacific Northwest (PNW) Research Station during fiscal year 2008. The mission of the PNW Research Station is to generate and communicate scientific knowledge that helps people understand and make informed choices about people, natural resources, and the environment. The work...

International Space Station Science Research Accomplishments During the Assembly Years: An Analysis of Results from 2000-2008

Science.gov (United States)

Evans, Cynthia A.; Robinson, Julie A.; Tate-Brown, Judy; Thumm, Tracy; Crespo-Richey, Jessica; Baumann, David; Rhatigan, Jennifer

2009-01-01

This report summarizes research accomplishments on the International Space Station (ISS) through the first 15 Expeditions. When research programs for early Expeditions were established, five administrative organizations were executing research on ISS: bioastronautics research, fundamental space biology, physical science, space product development, and space flight. The Vision for Space Exploration led to changes in NASA's administrative structures, so we have grouped experiments topically by scientific themes human research for exploration, physical and biological sciences, technology development, observing the Earth, and educating and inspiring the next generation even when these do not correspond to the administrative structure at the time at which they were completed. The research organizations at the time at which the experiments flew are preserved in the appendix of this document. These investigations on the ISS have laid the groundwork for research planning for Expeditions to come. Humans performing scientific investigations on ISS serve as a model for the goals of future Exploration missions. The success of a wide variety of investigations is an important hallmark of early research on ISS. Of the investigations summarized here, some are completed with results released, some are completed with preliminary results, and some remain ongoing.

A Strategy for Accomplishing Human-Performance Monitoring of Constructing NPPs

Energy Technology Data Exchange (ETDEWEB)

Sung, Chanho; Jung, Yeonsub [KHNP Central Research Institute, Daejeon (Korea, Republic of)

2015-10-15

The main purpose of HPM(Human performance monitoring) is that no significant safety degradation occurs due to changes in design, procedures, training, or staffing during the plant operation. Accordingly, the strategy for accomplishing HPM should be to maintain the acceptable level of human performance for safety operation. This paper presents a strategy to fulfill HPM effectively for constructing NPPs in Korea. Activities for HPM in constructing plants need to be divided into two large parts on the basis of the fuel loading, which could be a good strategy to accomplish HPM effectively. That is, the activities such as making HPM plan and developing its indexes are performed before the fuel loading, while the activities of maintaining acceptable HP levels are conducted after the fuel loading. This HPM strategy includes not only maintaining the criteria of human performance established during ISV, but also improving human performance through existing activities during the plant operation. Constructing plants will also make actively use of the existing programs for enhancing human performance.

The virtual accomplishment of knitting

DEFF Research Database (Denmark)

Heinemann, T.; Möller, R. L.

2016-01-01

. This means, among other things, that learners need to detect, diagnose and correct their errors without assistance from an expert. In this paper we focus on how this is accomplished by individuals attempting to learn how to knit by following instructions from a video tutorial. We show that novice knitters...

Advanced fuels campaign 2013 accomplishments

Energy Technology Data Exchange (ETDEWEB)

Braase, Lori [Idaho National Lab. (INL), Idaho Falls, ID (United States); Hamelin, Doug [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2013-10-01

The mission of the Advanced Fuels Campaign (AFC) is to perform Research, Development, and Demonstration (RD&D) activities for advanced fuel forms (including cladding) to enhance the performance and safety of the nation’s current and future reactors; enhance proliferation resistance of nuclear fuel; effectively utilize nuclear energy resources; and address the longer-term waste management challenges. This includes development of a state-of-the art Research and Development (R&D) infrastructure to support the use of “goal-oriented science-based approach.” In support of the Fuel Cycle Research and Development (FCRD) program, AFC is responsible for developing advanced fuels technologies to support the various fuel cycle options defined in the Department of Energy (DOE) Nuclear Energy Research and Development Roadmap, Report to Congress, April 2010. Accomplishments made during fiscal year (FY) 2013 are highlighted in this report, which focuses on completed work and results. The process details leading up to the results are not included; however, the technical contact is provided for each section.

Separations and Waste Forms Research and Development FY 2013 Accomplishments Report

Energy Technology Data Exchange (ETDEWEB)

None, None

2013-12-01

The Separations and Waste Form Campaign (SWFC) under the U.S. Department of Energy (DOE) Fuel Cycle Research and Development Program (FCRD) is responsible for developing advanced separation and waste form technologies to support the various fuel cycle options defined in the DOE Nuclear Energy Research and Development Roadmap, Report to Congress, April 2010. The fiscal year (FY) 2013 accomplishments report provides a highlight of the results of the research and development (R&D) efforts performed within SWFC in FY 2013. Each section contains a high-level overview of the activities, results, technical point of contact, applicable references, and documents produced during the fiscal year. This report briefly outlines campaign management and integration activities, but the intent of the report is to highlight the many technical accomplishments made during FY 2013.

Health and environmental research. Summary of accomplishments

Energy Technology Data Exchange (ETDEWEB)

1984-04-01

This is a short account of a 40-year-old health and environmental research program performed in national laboratories, universities, and research institutes. Under the sponsorship of the federal agencies that were consecutively responsible for the national energy mission, this research program has contributed to the understanding of the human health and environmental effects of emergining energy technologies. In so doing, it has also evolved several nuclear techniques for the diagnosis and treatment of human ills. The form of this presentation is through examples of significant, tangible accomplishments in each of these areas at certain times to illustrate the role and impact of the research program. The narrative of this research program concludes with a perspective of its past and a prospectus on its future.

Material Recovery and Waste Form Development FY 2015 Accomplishments Report

Energy Technology Data Exchange (ETDEWEB)

Todd, Terry Allen [Idaho National Lab. (INL), Idaho Falls, ID (United States); Braase, Lori Ann [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-11-01

The Material Recovery and Waste Form Development (MRWFD) Campaign under the U.S. Department of Energy (DOE) Fuel Cycle Technologies (FCT) Program is responsible for developing advanced separation and waste form technologies to support the various fuel cycle options defined in the DOE Nuclear Energy Research and Development Roadmap, Report to Congress, April 2010. The FY 2015 Accomplishments Report provides a highlight of the results of the research and development (R&D) efforts performed within the MRWFD Campaign in FY-14. Each section contains a high-level overview of the activities, results, technical point of contact, applicable references, and documents produced during the fiscal year. This report briefly outlines campaign management and integration activities, but primarily focuses on the many technical accomplishments made during FY-15. The campaign continued to utilize an engineering driven-science-based approach to maintain relevance and focus. There was increased emphasis on development of technologies that support near-term applications that are relevant to the current once-through fuel cycle.

IMHEX fuel cell repeat component manufacturing continuous improvement accomplishments

Energy Technology Data Exchange (ETDEWEB)

Jakaitis, L.A.; Petraglia, V.J.; Bryson, E.S. [M-C Power Corp., Burr Ridge, IL (United States)] [and others

1996-12-31

M-C Power is taking a power generation technology that has been proven in the laboratory and is making it a commercially competitive product. There are many areas in which this technology required scale up and refinement to reach the market entry goals for the IMHEX{reg_sign} molten carbonate fuel cell power plant. One of the primary areas that needed to be addressed was the manufacturing of the fuel cell stack. Up to this point, the fuel cell stack and associated components were virtually hand made for each system to be tested. M-C Power has now continuously manufactured the repeat components for three 250 kW stacks. M-C Power`s manufacturing strategy integrated both evolutionary and revolutionary improvements into its comprehensive commercialization effort. M-C Power`s objectives were to analyze and continuously improve stack component manufacturing and assembly techniques consistent with established specifications and commercial scale production requirements. Evolutionary improvements are those which naturally occur as the production rates are increased and experience is gained. Examples of evolutionary (learning curve) improvements included reducing scrap rates and decreasing raw material costs by buying in large quantities. Revolutionary improvements result in significant design and process changes to meet cost and performance requirements of the market entry system. Revolutionary changes often involve identifying new methods and developing designs to accommodate the new process. Based upon our accomplishments, M-C Power was able to reduce the cost of continuously manufactured fuel cell repeat components from the first to third 250 kW stack by 63%. This paper documents the continuous improvement accomplishments realized by M-C Power during IMHEX{reg_sign} fuel cell repeat component manufacturing.

Overview of LAMPF and its accomplishments

International Nuclear Information System (INIS)

Rosen, L.

1978-04-01

The report presented is from a talk given at a Los Alamos Scientific Laboratory colloquium on October 4, 1977, in which the history, technological accomplishments, present status, and scientific program at the Clinton P. Anderson Meson Physics Facility (LAMPF) were reviewed

Advanced Fuels Campaign 2012 Accomplishments

Energy Technology Data Exchange (ETDEWEB)

Not Listed

2012-11-01

The Advanced Fuels Campaign (AFC) under the Fuel Cycle Research and Development (FCRD) program is responsible for developing fuels technologies to support the various fuel cycle options defined in the DOE Nuclear Energy Research and Development Roadmap, Report to Congress, April 2010. The fiscal year 2012 (FY 2012) accomplishments are highlighted below. Kemal Pasamehmetoglu is the National Technical Director for AFC.

Significant ELCAP analysis results: Summary report. [End-use Load and Consumer Assessment Program

Energy Technology Data Exchange (ETDEWEB)

Pratt, R.G.; Conner, C.C.; Drost, M.K.; Miller, N.E.; Cooke, B.A.; Halverson, M.A.; Lebaron, B.A.; Lucas, R.G.; Jo, J.; Richman, E.E.; Sandusky, W.F. (Pacific Northwest Lab., Richland, WA (USA)); Ritland, K.G. (Ritland Associates, Seattle, WA (USA)); Taylor, M.E. (USDOE Bonneville Power Administration, Portland, OR (USA)); Hauser, S.G. (Solar Energy Research Inst., Golden, CO (USA))

1991-02-01

The evolution of the End-Use Load and Consumer Assessment Program (ELCAP) since 1983 at Bonneville Power Administration (Bonneville) has been eventful and somewhat tortuous. The birth pangs of a data set so large and encompassing as this have been overwhelming at times. The early adolescent stage of data set development and use has now been reached and preliminary results of early analyses of the data are becoming well known. However, the full maturity of the data set and the corresponding wealth of analytic insights are not fully realized. This document is in some sense a milestone in the brief history of the program. It is a summary of the results of the first five years of the program, principally containing excerpts from a number of previous reports. It is meant to highlight significant accomplishments and analytical results, with a focus on the principal results. Many of the results have a broad application in the utility load research community in general, although the real breadth of the data set remains largely unexplored. The first section of the document introduces the data set: how the buildings were selected, how the metering equipment was installed, and how the data set has been prepared for analysis. Each of the sections that follow the introduction summarize a particular analytic result. A large majority of the analyses to date involve the residential samples, as these were installed first and had highest priority on the analytic agenda. Two exploratory analyses using commercial data are included as an introduction to the commercial analyses that are currently underway. Most of the sections reference more complete technical reports which the reader should refer to for details of the methodology and for more complete discussion of the results. Sections have been processed separately for inclusion on the data base.

Biomass Program 2007 Accomplishments - Full Report

Energy Technology Data Exchange (ETDEWEB)

none,

2009-10-27

The Office of Energy Efficiency and Renewable Energy's (EERE’s) Biomass Program works with industry, academia and its national laboratory partners on a balanced portfolio of research in biomass feedstocks and conversion technologies. This document provides Program accomplishments for 2007.

Biomass Program 2007 Accomplishments - Report Introduction

Energy Technology Data Exchange (ETDEWEB)

none,

2009-10-27

The Office of Energy Efficiency and Renewable Energy's (EERE’s) Biomass Program works with industry, academia and its national laboratory partners on a balanced portfolio of research in biomass feedstocks and conversion technologies. This document provides the introduction to the 2007 Program Accomplishments Report.

Working Memory and Short-Term Memory Abilities in Accomplished Multilinguals

Science.gov (United States)

Biedron, Adriana; Szczepaniak, Anna

2012-01-01

The role of short-term memory and working memory in accomplished multilinguals was investigated. Twenty-eight accomplished multilinguals were compared to 36 mainstream philology students. The following instruments were used in the study: three memory subtests of the Wechsler Intelligence Scale (Digit Span, Digit-Symbol Coding, and Arithmetic,…

Accomplishments and challenges of the severe accident research

International Nuclear Information System (INIS)

Sehga, B.R.

1998-01-01

This paper describes the progress of the severe accident research since 1980, in terms of the accomplishments made so far and the challenges that remain. Much has been accomplished: many important safety issues have been resolved and consensus is near on some others. However, some of the previously identified safety issues remain as challenges, while some new ones have arisen due to the shift in focus from containment integrity to vessel integrity. New reactor designs have also created some new challenges. In general, the regulatory demands in new reactor designs are much stricter, thereby requiring much greater attention to the safety issues concerned with the containment design of the new large reactors

Business accomplishments, gender and entrepreneurial self-image

NARCIS (Netherlands)

A.R. Thurik (Roy); I. Verheul (Ingrid); L.M. Uhlaner (Lorraine)

2003-01-01

textabstractDrawing on Bem’s psychological theory of self-perception, this paper presents and tests a model that examines the impact of business accomplishments and gender on entrepreneurial self-image and explores the definition of entrepreneurship according to Vesper’s Entrepreneurial Typology.

Northeast Regional Biomass Program: Mission, accomplishments, prospects, 1991

International Nuclear Information System (INIS)

1991-03-01

This 1991 Report contains an update on the mission, goals and accomplishments of the Northeast Regional Biomass Program (NRBP). It describes the activities conducted during the past two years and incorporates the information contained in the 1989 publication of the NRBP Five Year Report. It describes the biomass projects conducted by the individual states of the Northeast Region, and summarizes the results from the Program's technical studies. Publications from both the state and regional projects are listed as well. An appendix lists the biomass-fired electricity generating stations planned or in operation in the region. The NRBP began in 1983 by developing a five year plan to guide its work. Within that time frame, the NRBP undertook over 20 applied research and technology transfer projects, and supported and guided the work of its eleven member states. During and since that period, the NRBP has brought together public and private sector organizations to promote the use in the Northeast of biomass and municipal waste energy resources and technologies. The NRBP's long-range plan was updated in 1990. In light of the accomplishments of the NRBP and the remaining challenges, this Report considers directions for future efforts. The Northeast has abundant biomass resources and markets for their use as energy. Meeting this potential will contribute to reducing the atmospheric greenhouse effect and dependence on imported oil. 49 refs

5 CFR 3301.102 - Procedure for accomplishing disqualification.

Science.gov (United States)

2010-01-01

... ETHICAL CONDUCT FOR EMPLOYEES OF THE DEPARTMENT OF ENERGY § 3301.102 Procedure for accomplishing...) Disqualification from matter effecting prospective employers. A DOE employee who is required, in accordance with 5...

Non-proliferation and nuclear cooperation - accomplishments and challenges

International Nuclear Information System (INIS)

Marshall, H.R. Jr.

1983-01-01

The purpose of this paper is to assess the accomplishments in non-proliferation and nuclear co-operation since the beginning of President Reagan's administration, and the challenges remaining to be met in those fields. (NEA) [fr

The genetics of music accomplishment: evidence for gene-environment correlation and interaction.

Science.gov (United States)

Hambrick, David Z; Tucker-Drob, Elliot M

2015-02-01

Theories of skilled performance that emphasize training history, such as K. Anders Ericsson and colleagues' deliberate-practice theory, have received a great deal of recent attention in both the scientific literature and the popular press. Twin studies, however, have demonstrated evidence for moderate-to-strong genetic influences on skilled performance. Focusing on musical accomplishment in a sample of over 800 pairs of twins, we found evidence for gene-environment correlation, in the form of a genetic effect on music practice. However, only about one quarter of the genetic effect on music accomplishment was explained by this genetic effect on music practice, suggesting that genetically influenced factors other than practice contribute to individual differences in music accomplishment. We also found evidence for gene-environment interaction, such that genetic effects on music accomplishment were most pronounced among those engaging in music practice, suggesting that genetic potentials for skilled performance are most fully expressed and fostered by practice.

Research accomplishments in particle physics: Annual progress report

International Nuclear Information System (INIS)

1988-01-01

This document presents our report of the research accomplishments of Boston University researchers in six projects in high energy physics research: Colliding Beams Physics; Proton Decay; Monopole Detection with MACRO; Precision Muon G-2 Experiment; Accelerator Design Physics; and Theoretical Physics

Idaho National Laboratory Mission Accomplishments, Fiscal Year 2015

Energy Technology Data Exchange (ETDEWEB)

Allen, Todd Randall [Idaho National Lab. (INL), Idaho Falls, ID (United States); Wright, Virginia Latta [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-09-01

A summary of mission accomplishments for the research organizations at the Idaho National Laboratory for FY 2015. Areas include Nuclear Energy, National and Homeland Security, Science and Technology Addressing Broad DOE Missions; Collaborations; and Stewardship and Operation of Research Facilities.

Accomplishments and challenges of the severe accident research

International Nuclear Information System (INIS)

Sehgal, B.R.

2001-01-01

This paper briefly describes the progress of the severe accident research since 1980, in terms of the accomplishments made so far and the challenges that remain. Much has been accomplished: many important safety issues have been resolved and consensus is near on some others. However, some of the previously identified safety issues remain as challenges, while some new ones have arisen due to the shift in focus from containment to vessel integrity. New reactor designs have also created some new challenges. In general, the regulatory demands for new reactor designs are stricter, thereby requiring much greater attention to the safety issues concerned with the containment design of the new large reactors, and to the accident management procedures for mitigating the consequences of a severe accident. We apologize for not providing references to many fine investigations that contributed to the great progress made so far in the severe accident research

China Accomplished Its First Space Rendezvous and Docking

Institute of Scientific and Technical Information of China (English)

Chen Xiaoli

2011-01-01

At 1:36 am on November 3,China's Shenzhou 8 unmanned spaceship and Tiangong 1 space lab spacecraft accomplished the country's first space docking procedure and coupling in space at more than 343km above Earth's surface,marking a great leap in China's space program.

GESAMP: Two decades of accomplishments

International Nuclear Information System (INIS)

Windom, H.L

1991-01-01

Many of the uses of the oceans by society may lead potentially to the degradation of the marine environment. Human activities on land lead to the inadvertent or deliberate input of contaminants to the oceans which also may result in marine environmental degradation on local, regional or global scales. Potential impacts on the marine environment of human activities on land and the potential conflicts of society's utilization of the oceans require ongoing global evaluation from a multidisciplinary scientific perspective. This has been recognized for some time by the community of United Nations organizations, eight of which jointly sponsor an interdisciplinary groups of scientists to provide independent advice on existing and potential marine pollution problems. This Group of Experts on the Scientific Aspects of Marine Pollution (GESAMP) was formed two decades ago to serve as a mechanism for encouraging coordination, collaboration and harmonization of activities related to marine pollution of common interest to the co-sponsoring bodies. More recently, GESAMP has expanded its programme to include consideration of the impacts of other human activities, such as coastal development, on the marine environment. The purpose of this booklet is to briefly describe what GESAMP is, how it operates and what it accomplishes

Capacity of small groups of muscles to accomplish precision grasping tasks.

Science.gov (United States)

Towles, Joseph D; Valero-Cuevas, Francisco J; Hentz, Vincent R

2013-01-01

An understanding of the capacity or ability of various muscle groups to generate endpoint forces that enable grasping tasks could provide a stronger biomechanical basis for the design of reconstructive surgery or rehabilitation for the treatment of the paralyzed or paretic hand. We quantified two-dimensional endpoint force distributions for every combination of the muscles of the index finger, in cadaveric specimens, to understand the capability of muscle groups to produce endpoint forces that accomplish three common types of grasps-tripod, tip and lateral pinch-characterized by a representative level of Coulomb friction. We found that muscle groups of 4 or fewer muscles were capable of generating endpoint forces that enabled performance of each of the grasping tasks examined. We also found that flexor muscles were crucial to accomplish tripod pinch; intrinsic muscles, tip pinch; and the dorsal interosseus muscle, lateral pinch. The results of this study provide a basis for decision making in the design of reconstructive surgeries and rehabilitation approaches that attempt to restore the ability to perform grasping tasks with small groups of muscles.

Message from the ISCB: 2015 ISCB Accomplishment by a Senior Scientist Award: Cyrus Chothia.

Science.gov (United States)

Fogg, Christiana N; Kovats, Diane E

2015-07-01

The International Society for Computational Biology (ISCB; http://www.iscb.org) honors a senior scientist annually for his or her outstanding achievements with the ISCB Accomplishment by a Senior Scientist Award. This award recognizes a leader in the field of computational biology for his or her significant contributions to the community through research, service and education. Cyrus Chothia, an emeritus scientist at the Medical Research Council Laboratory of Molecular Biology and emeritus fellow of Wolfson College at Cambridge University, England, is the 2015 ISCB Accomplishment by a Senior Scientist Award winner.Chothia was selected by the Awards Committee, which is chaired by Dr Bonnie Berger of the Massachusetts Institute of Technology. He will receive his award and deliver a keynote presentation at 2015 Intelligent Systems for Molecular Biology/European Conference on Computational Biology in Dublin, Ireland, in July 2015. dkovats@iscb.org. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

NASA total quality management 1990 accomplishments report

Science.gov (United States)

1991-01-01

NASA's efforts in Total Quality Management are based on continuous improvement and serve as a foundation for NASA's present and future endeavors. Given here are numerous examples of quality strategies that have proven effective and efficient in a time when cost reduction is critical. These accomplishment benefit our Agency and help to achieve our primary goal, keeping American in the forefront of the aerospace industry.

Accomplishments Report for the National Strategy for Electronics Stewardship

Science.gov (United States)

This page holds the NSES report, which charts the progress and accomplishments of the NSES in addressing sustainable management of electronics and highlights the benefits of continued leadership from the federal government.

So much to do, so little time. To accomplish the mandatory initiatives of ARRA, healthcare organizations will require significant and thoughtful planning, prioritization and execution.

Science.gov (United States)

Klein, Kimberly

2010-01-01

The American Recovery and Reinvestment Act of 2009 (ARRA) has set forth legislation for the healthcare community to achieve adoption of electronic health records (EHR), as well as form data standards, health information exchanges (HIE) and compliance with more stringent security and privacy controls under the HITECH Act. While the Office of the National Coordinator for Health Information Technology (ONCHIT) works on the definition of both "meaningful use" and "certification" of information technology systems, providers in particular must move forward with their IT initiatives to achieve the basic requirements for Medicare and Medicaid incentives starting in 2011, and avoid penalties that will reduce reimbursement beginning in 2015. In addition, providers, payors, government and non-government stakeholders will all have to balance the implementation of EHRs, working with HIEs, at the same time that they must upgrade their systems to be in compliance with ICD-10 and HIPAA 5010 code sets. Compliance deadlines for EHRs and HIEs begin in 2011, while ICD-10 diagnosis and procedure code sets compliance is required by October 2013 and HIPAA 5010 transaction sets, with one exception, is required by January 1, 2012. In order to accomplish these strategic and mandatory initiatives successfully and simultaneously, healthcare organizations will require significant and thoughtful planning, prioritization and execution.

Advanced Fuels Campaign FY 2014 Accomplishments Report

Energy Technology Data Exchange (ETDEWEB)

Braase, Lori [Idaho National Lab. (INL), Idaho Falls, ID (United States). INL Systems Analyses; May, W. Edgar [Idaho National Lab. (INL), Idaho Falls, ID (United States). INL Systems Analyses

2014-10-01

accident conditions than traditional fuel systems. AFC management and integration activities included continued support for international collaborations, primarily with France, Japan, the European Union, Republic of Korea, and China, as well as various working group and expert group activities in the Organization for Economic Cooperation and Development Nuclear Energy Agency (OECD-NEA) and the International Atomic Energy Agency (IAEA). Three industry-led Funding Opportunity Announcements (FOAs) and two university-led Integrated Research Projects (IRPs), funded in 2013, made significant progress in fuels and materials development. All are closely integrated with AFC and Accident Tolerant Fuels (ATF) research. Accomplishments made during fiscal year (FY) 2014 are highlighted in this report, which focuses on completed work and results. The process details leading up to the results are not included; however, the lead technical contact is provided for each section.

FTA fuel cell bus program : research accomplishments through 2011.

Science.gov (United States)

2012-03-01

Prepared by the Federal Transit Administration (FTA) Office of Research, Demonstration, and Innovation (TRI), this report summarizes the accomplishments of fuel-cell-transit-bus-related research and demonstrations projects supported by FTA through 20...

Accomplishments and needs in safety research

International Nuclear Information System (INIS)

Beckjord, E.S.

1988-01-01

My purpose today is to review recent accomplishments in water reactor safety research and to point out important tasks that remain to be done. I will also comment on the changes of focus that I see ahead in reactor safety research. I speak from a U.S. perspective on the subject, but note that the program of the U.S. Nuclear Regulatory Commission and also that of the U.S. industry's Electric Power Research Institute include many international collaborative research efforts. Without any doubt, nuclear safety research today is international in scope, and the collaborative movement is gaining in strength

Are studies reporting significant results more likely to be published?

Science.gov (United States)

Koletsi, Despina; Karagianni, Anthi; Pandis, Nikolaos; Makou, Margarita; Polychronopoulou, Argy; Eliades, Theodore

2009-11-01

Our objective was to assess the hypothesis that there are variations of the proportion of articles reporting a significant effect, with a higher percentage of those articles published in journals with impact factors. The contents of 5 orthodontic journals (American Journal of Orthodontics and Dentofacial Orthopedics, Angle Orthodontist, European Journal of Orthodontics, Journal of Orthodontics, and Orthodontics and Craniofacial Research), published between 2004 and 2008, were hand-searched. Articles with statistical analysis of data were included in the study and classified into 4 categories: behavior and psychology, biomaterials and biomechanics, diagnostic procedures and treatment, and craniofacial growth, morphology, and genetics. In total, 2622 articles were examined, with 1785 included in the analysis. Univariate and multivariate logistic regression analyses were applied with statistical significance as the dependent variable, and whether the journal had an impact factor, the subject, and the year were the independent predictors. A higher percentage of articles showed significant results relative to those without significant associations (on average, 88% vs 12%) for those journals. Overall, these journals published significantly more studies with significant results, ranging from 75% to 90% (P = 0.02). Multivariate modeling showed that journals with impact factors had a 100% increased probability of publishing a statistically significant result compared with journals with no impact factor (odds ratio [OR], 1.99; 95% CI, 1.19-3.31). Compared with articles on biomaterials and biomechanics, all other subject categories showed lower probabilities of significant results. Nonsignificant findings in behavior and psychology and diagnosis and treatment were 1.8 (OR, 1.75; 95% CI, 1.51-2.67) and 3.5 (OR, 3.50; 95% CI, 2.27-5.37) times more likely to be published, respectively. Journals seem to prefer reporting significant results; this might be because of authors

FY 1995 research highlights: PNL accomplishments in OER programs

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-10-01

Pacific Northwest Laboratory (PNL) conducts fundamental and applied research in support of the US Department of Energy`s (DOE) core missions in science and technology, environmental quality, energy resources, and national security. Much of this research is funded by the program offices of DOE`s Office of Energy Research (DOE-ER), primarily the Office of Basic Energy Sciences (BES) and the Office of Health and Environmental Research (OHER), and by PNL`s Laboratory Directed Research and Development (LDRD) Program. This document is a collection of research highlights that describe PNL`s accomplishments in DOE-ER funded programs during Fiscal Year 1995. Included are accomplishments in research funded by OHER`s Analytical Technologies, Environmental Research, Health Effects, General Life Sciences, and Carbon Dioxide Research programs; BES`s Materials Science, Chemical Sciences, Engineering and Geoscience, and Applied Mathematical Sciences programs; and PNL`s LDRD Program. Summaries are given for 70 projects.

Innovative Partnerships Program Accomplishments: 2009-2010 at NASA's Kennedy Space Center

Science.gov (United States)

Makufka, David

2010-01-01

This document reports on the accomplishments of the Innovative Partnerships Program during the two years of 2009 and 2010. The mission of the Innovative Partnerships Program is to provide leveraged technology alternatives for mission directorates, programs, and projects through joint partnerships with industry, academia, government agencies, and national laboratories. As outlined in this accomplishments summary, the IPP at NASA's Kennedy Space Center achieves this mission via two interdependent goals: (1) Infusion: Bringing external technologies and expertise into Kennedy to benefit NASA missions, programs, and projects (2) Technology Transfer: Spinning out space program technologies to increase the benefits for the nation's economy and humanity

Knowledge translation in health care as a multimodal interactional accomplishment

DEFF Research Database (Denmark)

Kjær, Malene

2014-01-01

of their education where they are in clinical practice. The analysis is made possible through video recordings of how student nurses translate their theoretical knowledge into a professional situational conduct in everyday interactional accomplishments among supervisors and patients. The analysis shows how some......In the theory of health care, knowledge translation is regarded as a crucial phenomenon that makes the whole health care system work in a desired manner. The present paper studies knowledge translation from the student nurses’ perspective and does that through a close analysis of the part...... knowledge gets translated through the use of rich multimodal embodied interactions, whereas the more abstract aspects of knowledge remain untranslated. Overall, the study contributes to the understanding of knowledge translation as a multimodal, locally situated accomplishment....

Accomplish the Application Area in Cloud Computing

OpenAIRE

Bansal, Nidhi; Awasthi, Amit

2012-01-01

In the cloud computing application area of accomplish, we find the fact that cloud computing covers a lot of areas are its main asset. At a top level, it is an approach to IT where many users, some even from different companies get access to shared IT resources such as servers, routers and various file extensions, instead of each having their own dedicated servers. This offers many advantages like lower costs and higher efficiency. Unfortunately there have been some high profile incidents whe...

RISK ANALYSIS FOR SHIP CONVERTING PROJECT ACCOMPLISHMENT (Case study of KRI KP Converting Project

Directory of Open Access Journals (Sweden)

Dimas Endro W

2013-10-01

Full Text Available Ship converting has become as prospective activity in ship building area. Operational and economical aspect are the most dominant rationale. Baseon a new fuction of converted ship, a task list which contain several jobs that must be done is listed. This accomplishment schedule not only contain a task list, but also duration for certain job title. In practical apllication job duration is maintained based on experience of project manager.  Further more, total accomplish duration is setted as time accomplishment for the project. This setted time has become reference for the project bid. Occasionaly, if accomplishment time which offered is strict, than schedule slip become as potencial nightmare. For this situation, project manager has had a cristal clearconsideration to select a proper decision wheter he will take the tender offer or not. practically, project mananger has layed on his experience to handle previous project and face  penalty if the project delayed. This paper focussed on how to measure tender offer based on risk analysis, specially for converted ship tender which has a strike time accomplishment.A new application method to analysis proposed tender based on time and penalty parameter has become a topic of this paper.

The History and Accomplishments of the LIVESTRONG Young Adult Alliance.

Science.gov (United States)

Mathews-Bradshaw, Beth; Johnson, Rebecca; Kaplan, Stuart; Craddock, Kelli; Hayes-Lattin, Brandon

2011-03-01

This article outlines the history, background, and accomplishments of the LIVESTRONG Young Adult Alliance. The LIVESTRONG Young Adult Alliance, a program of the Lance Armstrong Foundation, was developed as a vehicle for a strategic plan designed to implement the Adolescent and Young Adult Oncology Progress Review Group (AYAO PRG) recommendations. The AYAO PRG was co-sponsored by Lance Armstrong Foundation and the National Cancer Institute (NCI); both LIVESTRONG and NCI provide strategic oversight and guidance to the Alliance. Highlights and accomplishments: The Alliance accomplishments include the publication of disease-specific retrospective analyses, funding of an AYA cohort study and biorepository proposal, publication of two position statements on guidelines for care of AYAs with cancer and training for AYA oncology health professionals, promotion of an international charter of rights for AYA cancer patients, creation and distribution of a survey to college health professionals, creation and implementation of a Cancer Centers Working Group and Institutional Review Board Toolkit, and continued growth and collaboration through an annual meeting. The growth and success of the Alliance has coincided with the growth of AYA oncology as a field. The collaborative environment of the Alliance draws together a diverse group of individuals united in the effort to increase survival rates and improve the quality of life for adolescents and young adults diagnosed with cancer.

Advanced Fuels Campaign FY 2015 Accomplishments Report

Energy Technology Data Exchange (ETDEWEB)

Braase, Lori Ann [Idaho National Lab. (INL), Idaho Falls, ID (United States); Carmack, William Jonathan [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-10-29

The mission of the Advanced Fuels Campaign (AFC) is to perform research, development, and demonstration (RD&D) activities for advanced fuel forms (including cladding) to enhance the performance and safety of the nation’s current and future reactors; enhance proliferation resistance of nuclear fuel; effectively utilize nuclear energy resources; and address the longer-term waste management challenges. This report is a compilation of technical accomplishment summaries for FY-15. Emphasis is on advanced accident-tolerant LWR fuel systems, advanced transmutation fuels technologies, and capability development.

Creating and Sustaining a Culture of Excellence: Insights from Accomplished University Team-Sport Coaches

Science.gov (United States)

Donoso-Morales, Daniela; Bloom, Gordon A.; Caron, Jeffrey G.

2017-01-01

Purpose: Winning several national championships is an extraordinary feat that very few university coaches have accomplished. The objective of this study was to investigate how some of Canada's most accomplished university team-sport coaches created and sustained a culture of excellence in their programs. Method: Six university coaches who had won…

Sandia technology engineering and science accomplishments

Energy Technology Data Exchange (ETDEWEB)

1993-03-01

Sandia is a DOE multiprogram engineering and science laboratory with major facilities at Albuquerque, New Mexico, and Livermore, California, and a test range near Tonapah, Nevada. We have major research and development responsibilities for nuclear weapons, arms control, energy, the environment, economic competitiveness, and other areas of importance to the needs of the nation. Our principal mission is to support national defense policies by ensuring that the nuclear weapon stockpile meets the highest standards of safety, reliability, security, use control, and military performance. Selected unclassified technical activities and accomplishments are reported here. Topics include advanced manufacturing technologies, intelligent machines, computational simulation, sensors and instrumentation, information management, energy and environment, and weapons technology.

The discursive accomplishment of regimes of automobility

DEFF Research Database (Denmark)

Lindegaard, Laura Bang

2016-01-01

conceptualisation of mobility, I address impacts of thought schemes and structures on current social and political discourses of mobility as I discuss and demonstrate how rationalities of advanced liberalism co-constitute a car-dependent way of living. Drawing on both studies of governmentality and ethnomethodology...... case study in a decentralised Danish village that demonstrates how citizens accomplish the rationalities that co-constitute their car-dependent mobility in discursive interaction. During the time of the case study (2010-11), the village was engaged in an energy village project, and the study...

The Mixed Waste Focus Area: Status and accomplishments

International Nuclear Information System (INIS)

Conner, J.E.

1997-01-01

The Mixed Waste Focus Area began operations in February of 1995. Its mission is to provide acceptable technologies that enable implementation of mixed waste treatment systems developed in partnership with end-users, stakeholders, tribal governments, and regulators. The MWFA will develop, demonstrate, and deliver implementable technologies for treatment of mixed waste within the DOE complex. Treatment refers to all post waste-generation activities including sampling and analysis, characterization, storage, processing, packaging, transportation, and disposal. The MWFA's mission arises from the Resources Conservation and Recovery Act (RCRA) as amended by the Federal Facility Compliance Act. Each DOE site facility that generates or stores mixed waste prepared a plan, the Site Treatment Plan, for developing treatment capacities and treating that waste. Agreements for each site were concluded with state regulators, resulting in Consent Orders providing enforceable milestones for achieving treatment of the waste. The paper discusses the implementation of the program, its status, accomplishments and goals for FY1996, and plans for 1997

Space Shuttle Program Primary Avionics Software System (PASS) Success Legacy -Major Accomplishments and Lessons Learned

Science.gov (United States)

Orr, James K.

2010-01-01

This presentation has shown the accomplishments of the PASS project over three decades and highlighted the lessons learned. Over the entire time, our goal has been to continuously improve our process, implement automation for both quality and increased productivity, and identify and remove all defects due to prior execution of a flawed process in addition to improving our processes following identification of significant process escapes. Morale and workforce instability have been issues, most significantly during 1993 to 1998 (period of consolidation in aerospace industry). The PASS project has also consulted with others, including the Software Engineering Institute, so as to be an early evaluator, adopter, and adapter of state-of-the-art software engineering innovations.

Predicting College Student Success: A Historical and Predictive Examination of High School Activities and Accomplishments

Science.gov (United States)

Davey, Carla Mae

2010-01-01

According to generational theorists, the interests and experiences of incoming students have fluctuated over time, with Millennial students being more engaged and accomplished than their predecessors. This project explored data from 1974-2007 to determine the actual trends in engagement and accomplishments for three generations of students. Over…

20180312 - US EPA-Unilever Collaborative Partnership: Accomplishments and Next Steps (SOT)

Science.gov (United States)

Reiterating the goals of the partnership, this summarizes the accomplishments and progress made so far in the collaboration, and announces a two phase extension focused on further development of high-throughput transcriptomic platform

National Fire Plan Research and Development 2004-2005 accomplishment report

Science.gov (United States)

Michael W. Hilbruner; Paul Keller

2007-01-01

This report highlights accomplishments achieved by USDA Forest Service National Fire Plan Research and Development projects from 2004 through 2005 in four key areas: firefighting, rehabilitation and restoration, hazardous fuels reduction, and community assistance. These highlights illustrate the broad range of knowledge and tools introduced and generated by the...

Abstracts and research accomplishments of university coal research projects

Energy Technology Data Exchange (ETDEWEB)

1991-06-01

The Principal Investigators of the grants supported by the University Coal Research Program were requested to submit abstracts and highlight accomplishments of their projects in time for distribution at a grantees conference. This book is a compilation of the material received in response to the request. Abstracts discuss the following area: coal science, coal surface science, reaction chemistry, advanced process concepts, engineering fundamentals and thermodynamics, environmental science.

Abstracts and research accomplishments of university coal research projects

International Nuclear Information System (INIS)

1991-06-01

The Principal Investigators of the grants supported by the University Coal Research Program were requested to submit abstracts and highlight accomplishments of their projects in time for distribution at a grantees conference. This book is a compilation of the material received in response to the request. Abstracts discuss the following area: coal science, coal surface science, reaction chemistry, advanced process concepts, engineering fundamentals and thermodynamics, environmental science

The eighth NASA total quality management accomplishments report, 1990

Science.gov (United States)

1990-01-01

The eighth annual accomplishments report provides numerous examples of quality strategies that have proven effective and efficient in a time when cost reduction is critical. NASA's continuous improvement efforts can provide insight for others to succeed in their own endeavors. The report covers: top management leadership and support, strategic planning, focus on the customer, employee training and recognition, employee empowerment and teamwork, measurement and analysis, and quality assurance.

Fort Collins Science Center fiscal year 2010 science accomplishments

Science.gov (United States)

Wilson, Juliette T.

2011-01-01

The scientists and technical professionals at the U.S. Geological Survey (USGS), Fort Collins Science Center (FORT), apply their diverse ecological, socioeconomic, and technological expertise to investigate complicated ecological problems confronting managers of the Nation's biological resources. FORT works closely with U.S. Department of the Interior (DOI) agency scientists, the academic community, other USGS science centers, and many other partners to provide critical information needed to help answer complex natural-resource management questions. In Fiscal Year 2010 (FY10), FORT's scientific and technical professionals conducted ongoing, expanded, and new research vital to the science needs and management goals of DOI, other Federal and State agencies, and nongovernmental organizations in the areas of aquatic systems and fisheries, climate change, data and information integration and management, invasive species, science support, security and technology, status and trends of biological resources (including the socioeconomic aspects), terrestrial and freshwater ecosystems, and wildlife resources, including threatened and endangered species. This report presents selected FORT science accomplishments for FY10 by the specific USGS mission area or science program with which each task is most closely associated, though there is considerable overlap. The report also includes all FORT publications and other products published in FY10, as well as staff accomplishments, appointments, committee assignments, and invited presentations.

2014 Science Accomplishments Report of the Pacific Northwest Research Station

Science.gov (United States)

Rhonda Mazza

2015-01-01

Communicating the scientific knowledge generated by the Pacific Northwest Research Station is integral to our mission. The 2014 Science Accomplishments reports highlights the breadth of the station’s research, the relevance of our science findings, and the application of these findings. The photographs throughout the report showcase the region where we work and how...

2013 Science Accomplishments Report of the Pacific Northwest Research Station

Science.gov (United States)

Rhonda Mazza

2014-01-01

Communicating the scientific knowledge generated by the Pacific Northwest Research Station is integral to our mission. The 2013 Science Accomplishments reports highlights the breadth of the station’s research, the relevance of our science findings, and the application of these findings. The photographs throughout the report showcase the region where we work and how...

National Low-Level Waste Management Program final summary report of key activities and accomplishments for fiscal year 1996

International Nuclear Information System (INIS)

Garcia, R.S.

1996-12-01

To assist the Department of Energy (DOE) in fulfilling its responsibilities under the Low-Level Radioactive Waste Policy Amendments Act of 1985, the National Low-Level Waste Management Program (NLLWMP) outlines the key activities tat the NLLWMP will accomplish in the following fiscal year. Additional activities are added during the fiscal year as necessary to accomplish programmatic goals. This report summarizes the activities and accomplishments of the NLLWMP during Fiscal Year 1996

National Low-Level Waste Management Program final summary report of key activities and accomplishments for fiscal year 1995

International Nuclear Information System (INIS)

Forman, S.

1995-12-01

To assist the Department of Energy (DOE) in fulfilling its responsibilities under the Low-Level Radioactive Waste Policy Amendments Act of 1985, the National Low-Level Waste Management Program (NLLWMP) outlines the key activities that the NLLWMP will accomplish in the following fiscal year. Additional activities are added during the fiscal year as necessary to accomplish programmatic goals. This report summarizes the activities and accomplishments of the NLLWMP during fiscal year 1995

29 CFR 779.218 - Methods to accomplish “unified operation.”

Science.gov (United States)

2010-07-01

..., join together to perform some or all of their activities as a unified business or business system. They may accomplish such unification through agreements, franchises, grants, leases, or other arrangements... others so that they constitute a single business or unified business system. Whether in any particular...

NGNP Process Heat Applications: Hydrogen Production Accomplishments for FY2010

Energy Technology Data Exchange (ETDEWEB)

Charles V Park

2011-01-01

This report summarizes FY10 accomplishments of the Next Generation Nuclear Plant (NGNP) Engineering Process Heat Applications group in support of hydrogen production technology development. This organization is responsible for systems needed to transfer high temperature heat from a high temperature gas-cooled reactor (HTGR) reactor (being developed by the INL NGNP Project) to electric power generation and to potential industrial applications including the production of hydrogen.

Personalized medicine: CCO's vision, accomplishments and future plans.

Science.gov (United States)

Guo, Jennifer; Kamel-Reid, Suzanne; Rutherford, Michael; Hart, Jennifer; Melamed, Saul; Pollett, Aaron

2015-01-01

Personalized medicine is a rapidly expanding field, with the potential to improve patient care. Its benefits include increasing efficiency in cancer screening, diagnosis and treatment through early detection, targeted therapy and identifying individuals with an underlying genetic risk for cancer or adverse outcomes. Through the work of Cancer Care Ontario (CCO)'s Pathology and Laboratory Medicine Program, a number of initiatives have been undertaken to support developments in personalized medicine. In keeping with the momentum of recent accomplishments, CCO has led the formation of the Personalized Medicine Steering Committee to develop a comprehensive provincial genetics strategy for the future of cancer care. Copyright © 2014 Longwoods Publishing.

Accomplishments and Compromises in Prediction Research for World Records and Best Performances in Track and Field and Swimming

Science.gov (United States)

Liu, Yuanlong; Paul, Stanley; Fu, Frank H.

2012-01-01

The conductors of this study reviewed prediction research and studied the accomplishments and compromises in predicting world records and best performances in track and field and swimming. The results of the study showed that prediction research only promises to describe the historical trends in track and field and swimming performances, to study…

Non-destructive testing: significant facts

International Nuclear Information System (INIS)

Espejo, Hector; Ruch, Marta C.

2006-01-01

In the last fifty years different organisations, both public and private, have been assigned to the mission of introducing into the country the most relevant aspects of the modern technological discipline 'Non Destructive Testing' (NDT) through a manifold of activities, such as training and education, research, development, technical assistance and services, personnel qualification/certification and standardisation. A review is given of the significant facts in this process, in which the Argentine Atomic Energy Commission, CNEA, played a leading part, a balance of the accomplishments is made and a forecast of the future of the activity is sketched. (author) [es

Research accomplishments and future goals in particle physics

International Nuclear Information System (INIS)

1991-12-01

This report presents the research accomplishments and ongoing activities of Boston University researchers in high energy physics. We are active in eight principal areas which are discussed in this report: Colliding Beams - physics of electron-positron annihilation; Accelerator Design Physics - advanced accelerator design; Monopole/ Neutrino - searchers for magnetic monopoles and for neutrino oscillations; Proton Decay - search for nucleon instability and study of nonaccelarator physics; Particle Theory - theoretical high energy particles physics; Muon G-2 - an experiment to measure the anomalous magnetic moment of the muon with a factor of 20 better precision than currently achieved; SSSintcal - scintillating fiber calorimetry for the SSC; and SSC Muon Detectors - development of muon detectors for the GEM Experiment at the SSC

Water Power Technologies Office 2017 Marine Energy Accomplishments

Energy Technology Data Exchange (ETDEWEB)

Water Power Technologies Office

2018-04-01

The U.S. Department of Energy's Water Power Technologies Office's marine and hydrokinetic portfolio has numerous projects that support industry advancement in wave, tidal, and ocean and river current technologies. In order to strengthen state-of-the-art technologies in these fields and bring them closer to commercialization, the Water Power Technologies Office funds industry, academia, and the national laboratories. A U.S. chapter on marine and hydrokinetic energy research and development was included in the Ocean Energy Systems' Technology Programme—an intergovernmental collaboration between countries, which operates under a framework established by the International Energy Agency. This brochure is an overview of the U.S. accomplishments and updates from that report.

Empowering Adult Learners. NIF Literacy Program Helps ABE Accomplish Human Development Mission.

Science.gov (United States)

Hurley, Mary E.

1991-01-01

The National Issues Forum's Literacy Program uses study circles and group discussion to promote empowerment and enhance adult literacy through civic education. The program has helped the Westonka (Minnesota) Adult Basic Education project accomplish its mission and has expanded the staff's view of adult learning. (SK)

Interpreting Statistical Significance Test Results: A Proposed New "What If" Method.

Science.gov (United States)

Kieffer, Kevin M.; Thompson, Bruce

As the 1994 publication manual of the American Psychological Association emphasized, "p" values are affected by sample size. As a result, it can be helpful to interpret the results of statistical significant tests in a sample size context by conducting so-called "what if" analyses. However, these methods can be inaccurate…

NASA total quality management 1989 accomplishments report

Science.gov (United States)

Tai, Betty P. (Editor); Stewart, Lynne M. (Editor)

1990-01-01

NASA and contractor employees achieved many notable improvements in 1989. The highlights of those improvements, described in this seventh annual Accomplishments Report, demonstrate that the people who support NASA's activities are getting more involved in quality and continuous improvement efforts. Their gains solidly support NASA's and this Nation's goal to remain a leader in space exploration and in world-wide market competition, and, when communicated to others through avenues such as this report, foster improvement efforts across government and industry. The principles in practice which led to these process refinements are important cultural elements to any organization's productivity and quality efforts. The categories in this report reflect NASA principles set forth in the 1980's and are more commonly known today as Total Quality Management (TQM): top management leadership and support; strategic planning; focus on the customer; employee training and recognition; employee empowerment and teamwork; measurement and analysis; and quality assurance.

Input significance analysis: feature ranking through synaptic weights ...

African Journals Online (AJOL)

a selected dataset taken from the UCI Machine Learning Repository and in an online environment and lastly to attest the FR results by using another selected dataset taken from the same source and in the same environment. There are three groups of experiments conducted to accomplish these goals. The results are ...

Volpe Center Annual Accomplishments: Advancing Transportation Innovation for the Public Good - January 2018

Science.gov (United States)

2018-01-01

The Volpe Centers Annual Accomplishments highlights our best work of 2017 and illustrates the sustained impact of the Volpe Center in supporting the U.S. DOTs top priorities and strategic goals: safety, infrastructure, innovation, and accountab...

Twenty years of ABACC: Accomplishments, lessons learnt and future perspectives

Energy Technology Data Exchange (ETDEWEB)

Peixoto, Orpet J.M. [ABACC- Brazilian Argentine Agency for Accounting and Control of Nuclear Materials, Rio de Janeiro (Brazil)

2012-06-15

From the inception of the implementation of the Quadripartite Agreement (INFCIRC/435), in 1991, ABACC has had an important role at the non-proliferation agenda and has also been an active player in the international safeguards. It was necessary for ABACC to develop a technical capacity to face the challenges to be a safeguards agency and to gain credibility in the nuclear safeguards world. This capacity means to develop and implement safeguards systems in the technical area, in the inspection framework, in the conceptual analysis of processes and approaches and in the political scenario. These tasks conducted the strategic plan of ABACC on the last 20 years. Among the accomplishments, ABACC has been involved in the application of safeguards to sensitive and complex installations, in developing safeguards instrumentation, in establishing a technical and trained inspectorate, in constructing a cooperative and coordinate environment with IAEA for safeguards application. Other challenges as R and D of equipment and quality assurance systems were also managed during all these years. ESARDA is one forum that ABACC is involved and always shares experience and ideas. On July 18th, 2011 ABACC will formally complete 20 years. This paper summarizes the accomplishments, lessons learnt and future actions for strengthen the ABACC safeguards role. It also addresses the collaboration of ABACC with other organizations in the non-proliferation and international safeguards arena.

The Ongoing Accomplishment of the Mobile Telecommunication: An Ethnomethodological Study of “Talking on a Mobile Phone”

Directory of Open Access Journals (Sweden)

Chia-Rong Tsao

2015-07-01

Full Text Available This paper attempts to explore the practices of “talking on a mobile phone” through the ethnomethodological approach. Instead of paying attention to the influences of the prevalence of mobile phones, this paper focuses on the ongoing accomplishment of the practices of cellphone-using. This paper contends that the mobile phone users accomplish the practices of “talking on a mobile phone” continuously by methods such as “reading hermeneutically”, “embodying”, “the documentary method of interpretation”, and “accounting reasonably”, etc. Users not only take these methods for granted, but also see but unnoticed what they really do by these cellphone-using practices. The practices identify and reproduce reflexively the structural influences brought by the prevalence of mobile phones while accomplishing the process of “talking on a mobile phone”.

The space shuttle program technologies and accomplishments

CERN Document Server

Sivolella, Davide

2017-01-01

This book tells the story of the Space Shuttle in its many different roles as orbital launch platform, orbital workshop, and science and technology laboratory. It focuses on the technology designed and developed to support the missions of the Space Shuttle program. Each mission is examined, from both the technical and managerial viewpoints. Although outwardly identical, the capabilities of the orbiters in the late years of the program were quite different from those in 1981. Sivolella traces the various improvements and modifications made to the shuttle over the years as part of each mission story. Technically accurate but with a pleasing narrative style and simple explanations of complex engineering concepts, the book provides details of many lesser known concepts, some developed but never flown, and commemorates the ingenuity of NASA and its partners in making each Space Shuttle mission push the boundaries of what we can accomplish in space. Using press kits, original papers, newspaper and magazine articles...

Reshaping American Energy - A Look Back at BETO's Accomplishments in 2013

Energy Technology Data Exchange (ETDEWEB)

None

2013-11-01

For more than a decade, BETO has been shaping the bioenergy industry. BETO helps transform the nation's renewable biomass resources into high-performance biofuels, biopower, and bioproducts. This fact sheet outlines some of our biggest accomplishments in 2013.

Consideration about moral accomplishment: a necessity in today’s world

Directory of Open Access Journals (Sweden)

Iulia Tutuianu

2015-12-01

Full Text Available Unlike in the atheist existentialism, the Christian one finds the individual in palpable situations, seen as opportunities in the process of personal accomplishment. The existentialism is not a quietude philosophy, but it asks for permanent effort. The religious man has a meaning, a purpose, The Encounter with Absolute, his entire life being part of Propedeutica. He replaces the anguish with hope, with the joy of being closed to God which occurs in each moment when we are aware that we follow our destiny.

Environmental Measurements Laboratory fiscal year 1998: Accomplishments and technical activities

Energy Technology Data Exchange (ETDEWEB)

Erickson, M.D.

1999-01-01

The Environmental Measurements Laboratory (EML) is government-owned, government-operated, and programmatically under the DOE Office of Environmental Management. The Laboratory is administered by the Chicago Operations Office. EML provides program management, technical assistance and data quality assurance for measurements of radiation and radioactivity relating to environmental restoration, global nuclear nonproliferation, and other priority issues for the Department of Energy, as well as for other government, national, and international organizations. This report presents the technical activities and accomplishments of EML for Fiscal Year 1998.

Accomplishments in 2007 in the treatment of advanced colorectal cancer.

Science.gov (United States)

Goldberg, Richard M; Carrato, Alfredo

2008-05-01

Overview of the Disease IncidencePrognosis Prognostic or Predictive FactorsCurrent General Therapy Standards and Regional Variations STANDARDS IN THE US AND EUROPE: Combination Therapy Plus a Biologic FOCUS and CAIRO 1: Serial Single Agents vs. Combination TherapyStop-and-Go StrategyLimited Availability of Biologics in Some RegionsAccomplishments During the Year TherapyWhat Needs To Be Done Controversies and Disagreements BOND-2 and PACCE: Chemotherapy + Bevacizumab + Cetuximab or PanitumumabSpecial Populations (Elderly and Poor Performance Status)Future Directions Comments on ResearchObstacles to Progress.

FY2000 Hanford Technology Deployment Accomplishments Fact Sheets

International Nuclear Information System (INIS)

WIBLE, R.A.

2001-01-01

Cleaning up the Hanford Site is one of the top priorities for the U. S. Department of Energy. The department is continually looking for ways to expedite cleanup and reduce costs. During Fiscal Year (FY) 2000. Hanford Site staff deployed 24 new technologies, which produced an estimated lifecycle cost savings of 479 million dollars. This is a clear indicator of the impacts new technology has had and will have on the cleanup efforts. The Hanford Site cleanup is focused on the following: Restoring the Columbia River Corridor; Building and operating the tank waste treatment complex to complete the cleanup of highly radioactive tank waste at Hanford; and Transitioning the Central Plateau. Applying innovative science and technology from national laboratories, universities, and private industry is critical to our complex cleanup mission. The 24 new technologies deployed in FY 2000 are significantly higher than our goal of 14 technological deployments. Eleven of these technologies supported restoring the Columbia River Corridor, and seven were involved with the remediation of radioactive tank waste. These deployments produced valuable information to determine the effectiveness of the new technologies in the field and the efficiencies gained over existing cleanup methods. In several cases, the technology deployed presented a solution to a problem where a clear path of remediation had not yet been determined. New and innovative technologies will play a significant role in the cleanup of the Hanford Site and enable remediation to be done more efficiently. Technology is being developed at a staggering pace. This requires excellent communication throughout the scientific and industry arenas. To effect this communication, we have implemented a technology needs process in conjunction with the multi-year work planning process. Through the combination of these two processes, technology developments and deployments address the near-term technology needs and enable us to plan for the

When Bioelectrochemical Systems Meet Forward Osmosis: Accomplishing Wastewater Treatment and Reuse through Synergy

Directory of Open Access Journals (Sweden)

Yaobin Lu

2014-12-01

Full Text Available Bioelectrochemical systems (BES and forward osmosis (FO are two emerging technologies with great potential for energy-efficient water/wastewater treatment. BES takes advantage of microbial interaction with a solid electron acceptor/donor to accomplish bioenergy recovery from organic compounds, and FO can extract high-quality water driven by an osmotic pressure. The strong synergy between those two technologies may complement each other and collaboratively address water-energy nexus. FO can assist BES with achieving water recovery (for future reuse, enhancing electricity generation, and supplying energy for accomplishing the cathode reactions; while BES may help FO with degrading organic contaminants, providing sustainable draw solute, and stabilizing water flux. This work has reviewed the recent development that focuses on the synergy between BES and FO, analyzed the advantages of each combination, and provided perspectives for future research. The findings encourage further investigation and development for efficient coordination between BES and FO towards an integrated system for wastewater treatment and reuse.

Recent Accomplishments in Laser-Photovoltaic Wireless Power Transmission

Science.gov (United States)

Fikes, John C.; Henley, Mark W.; Mankins, John C.; Howell, Joe T.; Fork, Richard L.; Cole, Spencer T.; Skinner, Mark

2003-01-01

Wireless power transmission can be accomplished over long distances using laser power sources and photovoltaic receivers. Recent research at AMOS has improved our understanding of the use of this technology for practical applications. Research by NASA, Boeing, the University of Alabama-Huntsville, the University of Colorado, Harvey Mudd College, and the Naval Postgraduate School has tested various commercial lasers and photovoltaic receiver configurations. Lasers used in testing have included gaseous argon and krypton, solid-state diodes, and fiber optic sources, at wavelengths ranging from the visible to the near infra-red. A variety of Silicon and Gallium Arsenide photovoltaic have been tested with these sources. Safe operating procedures have been established, and initial tests have been conducted in the open air at AMOS facilities. This research is progressing toward longer distance ground demonstrations of the technology and practical near-term space demonstrations.

New Accomplishments and Development of INIS in Croatia

International Nuclear Information System (INIS)

Novosel, N.; Pleslic Jovicic, S.

1998-01-01

International Nuclear Information System (INIS) is the leading information system on peaceful use of nuclear energy in the world. INIS is realized through co-operation of International Atomic Energy Agency (IAEA) and its member states. It contains information related to literature on nuclear science and technology in the form of a bibliographic record. The Republic of croatia became an INIS member at the end of 1994 and since then this database has been available in a written form as INIS Atomindex and on CD-ROM. Moreover, several representatives of expert organizations have been trained for searching the database and for formulating of input data for INIS. This article describes new accomplishments in the development of the INIS database and joining of Croatia into the international exchange of nuclear information through national contribution in the form of INIS input data. (author)

WISM - A Wideband Instrument for Snow Measurement: Past Accomplishments, Current Status, and Path Forward

Science.gov (United States)

Bonds, Quenton; Racette, Paul; Durham, Tim (Principal Investigator)

2016-01-01

Presented are the prior accomplishments, current status and path forward for GSFC's Wideband Instrument for Snow Measurement (WISM). This work is a high level overview of the project, presented via Webinar to the IEEE young professionals.

Lunabotics Mining Competition: Inspiration Through Accomplishment

Science.gov (United States)

Mueller, Robert P.

2011-01-01

NASA's Lunabotics Mining Competition is designed to promote the development of interest in space activities and STEM (Science, Technology, Engineering, and Mathematics) fields. The competition uses excavation, a necessary first step towards extracting resources from the regolith and building bases on the moon. The unique physical properties of lunar regolith and the reduced 1/6th gravity, vacuum environment make excavation a difficult technical challenge. Advances in lunar regolith mining have the potential to significantly contribute to our nation's space vision and NASA space exploration operations. The competition is conducted annually by NASA at the Kennedy Space Center Visitor Complex. The teams that can use telerobotic or autonomous operation to excavate a lunar regolith geotechnical simulant, herein after referred to as Black Point-1 (or BP-1) and score the most points (calculated as an average of two separate 10-minute timed competition attempts) will eam points towards the Joe Kosmo Award for Excellence and the scores will reflect ranking in the on-site mining category of the competition. The minimum excavation requirement is 10.0 kg during each competition attempt and the robotic excavator, referred to as the "Lunabot", must meet all specifications. This paper will review the achievements of the Lunabotics Mining Competition in 2010 and 2011, and present the new rules for 2012. By providing a framework for robotic design and fabrication, which culminates in a live competition event, university students have been able to produce sophisticated lunabots which are tele-operated. Multi-disciplinary teams are encouraged and the extreme sense of accomplishment provides a unique source of inspiration to the participating students, which has been shown to translate into increased interest in STEM careers. Our industrial sponsors (Caterpillar, Newmont Mining, Harris, Honeybee Robotics) have all stated that there is a strong need for skills in the workforce related

Amlodipine+benazepril is superior to hydrochlorothiazide+benazepril irrespective of baseline pulse pressure: subanalysis of the ACCOMPLISH trial.

Science.gov (United States)

Skoglund, Per H; Svensson, Per; Asp, Joline; Dahlöf, Björn; Kjeldsen, Sverre E; Jamerson, Kenneth A; Weber, Michael A; Jia, Yan; Zappe, Dion H; Östergren, Jan

2015-02-01

Pulse pressure (PP) is an independent risk factor for cardiovascular (CV) disease and death but few studies have investigated the effect of antihypertensive treatments in relation to PP levels before treatment. The Avoiding Cardiovascular Events Through Combination Therapy in Patients Living With Systolic Hypertension (ACCOMPLISH) trial showed that the combination of benazepril+amlodipine (B+A) is superior to benazepril+hydrochlorothiazide (B+H) in reducing CV events. We aimed to investigate whether the treatment effects in the ACCOMPLISH trial were dependent on baseline PP. High-risk hypertensive patients (n=11,499) were randomized to double-blinded treatment with single-pill combinations of either B+A or B+H and followed for 36 months. Patients were divided into tertiles according to their baseline PP and events (CV mortality/myocardial infarction or stroke) were compared. Hazard ratios (HRs) for the treatment effect (B+A over B+H) were calculated in a Cox regression model with age, coronary artery disease, and diabetes mellitus as covariates and were compared across the tertiles. The event rate was increased in the high tertile of PP compared with the low tertile (7.2% vs 4.4% P<.01). In the high and medium PP tertiles, HRs were 0.75 (95% confidence interval [CI], 0.60-0.95; P=.018) and 0.74 (CI, 0.56-0.98, P=.034), respectively, in favor of B+A. There was no significant difference between the treatments in the low tertile and no significant differences in treatment effect when comparing the HRs between tertiles of PP. B+A has superior CV protection over B+H in high-risk hypertensive patients independent of baseline PP although the absolute treatment effect is enhanced in the higher tertiles of PP where event rates are higher. © 2014 Wiley Periodicals, Inc.

Cementitious Barriers Partnership Accomplishments And Relevance To The DOE Complex

International Nuclear Information System (INIS)

Burns, H.; Langton, C.; Flach, G.; Kosson, D.

2010-01-01

The Cementitious Barriers Partnership (CBP) was initiated to reduce risk and uncertainties in the performance assessments that directly impact U.S. Department of Energy (DOE) environmental cleanup and closure programs. The CBP is supported by the DOE Office of Environmental Management (DOE-EM) and has been specifically addressing the following critical EM program needs: (i) the long-term performance of cementitious barriers and materials in nuclear waste disposal facilities and (ii) increased understanding of contaminant transport behavior within cementitious barrier systems to support the development and deployment of adequate closure technologies. To accomplish this, the CBP has two initiatives: (1) an experimental initiative to increase understanding of changes in cementitious materials over long times (> 1000 years) over changing conditions and (2) a modeling initiative to enhance and integrate a set of computational tools validated by laboratory and field experimental data to improve understanding and prediction of the long-term performance of cementitious barriers and waste forms used in nuclear applications. In FY10, the CBP developed the initial phase of an integrated modeling tool that would serve as a screening tool which could help in making decisions concerning disposal and tank closure. The CBP experimental programs are underway to validate this tool and provide increased understanding of how CM changes over time and under changing conditions. These initial CBP products that will eventually be enhanced are anticipated to reduce the uncertainties of current methodologies for assessing cementitious barrier performance and increase the consistency and transparency of the DOE assessment process. These tools have application to low activity waste forms, high level waste tank closure, D and D and entombment of major nuclear facilities, landfill waste acceptance criteria, and in-situ grouting and immobilization of vadose zone contamination. This paper

Skylab experiments. Volume 6: Mechanics. [Skylab program accomplishments for high school level education

Science.gov (United States)

1973-01-01

Skylab program activities are presented in a form adapted to instruction of high school students. The overall goals of the program are discussed. The specific accomplishments of the mechanics investigations are described. The subjects involved are as follows: (1) evaluation of mobility aids, (2) mass measurement devices, and (3) space guidance crew/vehicle disturbances.

Light Water Reactor Sustainability Accomplishments Report

Energy Technology Data Exchange (ETDEWEB)

McCarthy, Kathryn A. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-02-01

Welcome to the 2014 Light Water Reactor Sustainability (LWRS) Program Accomplishments Report, covering research and development highlights from 2014. The LWRS Program is a U.S. Department of Energy research and development program to inform and support the long-term operation of our nation’s commercial nuclear power plants. The research uses the unique facilities and capabilities at the Department of Energy national laboratories in collaboration with industry, academia, and international partners. Extending the operating lifetimes of current plants is essential to supporting our nation’s base load energy infrastructure, as well as reaching the Administration’s goal of reducing greenhouse gas emissions to 80% below 1990 levels by the year 2050. The purpose of the LWRS Program is to provide technical results for plant owners to make informed decisions on long-term operation and subsequent license renewal, reducing the uncertainty, and therefore the risk, associated with those decisions. In January 2013, 104 nuclear power plants operated in 31 states. However, since then, five plants have been shut down (several due to economic reasons), with additional shutdowns under consideration. The LWRS Program aims to minimize the number of plants that are shut down, with R&D that supports long-term operation both directly (via data that is needed for subsequent license renewal), as well indirectly (with models and technology that provide economic benefits). The LWRS Program continues to work closely with the Electric Power Research Institute (EPRI) to ensure that the body of information needed to support SLR decisions and actions is available in a timely manner. This report covers selected highlights from the three research pathways in the LWRS Program: Materials Aging and Degradation, Risk-Informed Safety Margin Characterization, and Advanced Instrumentation, Information, and Control Systems Technologies, as well as a look-ahead at planned activities for 2015. If you

Major accomplishments of America's nuclear rocket program (ROVER)

International Nuclear Information System (INIS)

Finseth, J.L.

1991-01-01

The United States embarked on a program to develop nuclear rocket engines in 1955. This program was known as project Rover. Initially nuclear rockets were considered as a potential backup for intercontinental ballistic missile propulsion but later proposed applications included both a lunar second stage as well as use in manned-Mars flights. Under the Rover program, 19 different reactors were built and tested during the period of 1959-1969. Additionally, several cold flow (non-fuelled) reactors were tested as well as a nuclear fuels test cell. The Rover program was terminated in 1973, due to budget constraints and an evolving political climate. The Rover program would have led to the development of a flight engine had the program continued through a logical continuation. The Rover program was responsible for a number of technological achievements. The successful operation of nuclear rocket engines on a system level represents the pinnacle of accomplishment. This paper will discuss the engine test program as well as several subsystems

EarthScope Education and Outreach: Accomplishments and Emerging Opportunities

Science.gov (United States)

Robinson, S.; Ellins, K. K.; Semken, S. C.; Arrowsmith, R.

2014-12-01

EarthScope's Education and Outreach (E&O) program aims to increase public awareness of Earth science and enhance geoscience education at the K-12 and college level. The program is distinctive among major geoscience programs in two ways. First, planning for education and public engagement occurred in tandem with planning for the science mission. Second, the NSF EarthScope program includes funding support for education and outreach. In this presentation, we highlight key examples of the program's accomplishments and identify emerging E&O opportunities. E&O efforts have been collaboratively led by the EarthScope National Office (ESNO), IRIS, UNAVCO, the EarthScope Education and Outreach Subcommittee (EEOSC) and PI-driven EarthScope projects. Efforts by the EEOSC, guided by an EarthScope Education and Outreach Implementation Plan that is periodically updated, focus EarthScope E&O. EarthScope demonstrated early success in engaging undergraduate students (and teachers) in its mission through their involvement in siting USArray across the contiguous U.S. Funded E&O programs such as TOTLE, Illinois EarthScope, CEETEP (for K-12), InTeGrate and GETSI (for undergraduates) foster use of freely available EarthScope data and research findings. The Next Generation Science Standards, which stress science and engineering practices, offer an opportunity for alignment with existing EarthScope K-12 educational resources, and the EEOSC recommends focusing efforts on this task. The EEOSC recognizes the rapidly growing use of mobile smart devices by the public and in formal classrooms, which bring new opportunities to connect with the public and students. This will capitalize on EarthScope's already prominent social media presence, an effort that developed to accomplish one of the primary goals of the EarthScope E&O Implementation Plan to "Create a high-profile public identity for EarthScope" and to "Promote science literacy and understanding of EarthScope among all audiences through

Quality management at Argonne National Laboratory: Status, accomplishments, and lessons learned

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-06-01

In April 1992, Argonne National Laboratory (ANL) launched the implementation of quality management (QM) as an initiative of the Laboratory Director. The goal of the program is to seek ways of improving Laboratory performance and effectiveness by drawing from the realm of experiences in the global total quality management movement. The Argonne QM initiative began with fact finding and formulating a strategy for implementation; the emphasis is that the underlying principles of QM should be an integral part of how the Laboratory is managed and operated. A primary theme that has guided the Argonne QM initiative is to consider only those practices that offer the potential for real improvement, make sense, fit the culture, and would be credible to the broad population. In October 1993, the Laboratory began to pilot a targeted set of QM activities selected to produce outcomes important to the Laboratory--strengthening the customer focus, improving work processes, enhancing employee involvement and satisfaction, and institutionalizing QM. This report describes the results of the just-concluded QM development and demonstration phase in terms of detailed strategies, accomplishments, and lessons learned. These results are offered as evidence to support the conclusion that the Argonne QM initiative has achieved value-added results and credibility and is well positioned to support future deployment across the entire Laboratory as an integrated management initiative. Recommendations for follow-on actions to implement future deployment are provided separately.

Estimation of the genetically significant dose resulting from diagnostic radiology

International Nuclear Information System (INIS)

Angerstein, W.

1978-01-01

Based on the average gonad dose received per examination or per film and on the frequency of x-ray examinations (36 million per annum), the mean annual gonad dose to individuals in the GDR has been determined to be 33 mR. Considering different age groups of patients and the fact that the gonad dose to children is often significantly reduced in comparison to adults, estimates of the genetically significant dose (GSD) range from 7 to 19 mR per annum. Examinations of women have accounted for about 66 per cent of the GSD. The highest contribution to the GSD result from examinations of the following organs: kidneys, colon, bile duct (only in women), lumbar spine, pelois, hips, and proximal femur. Despite their high frequency, examinations of the stomach account for only about 3 per cent of the GSD. All thorax examinations (nearly 10,000,000 per annum) contribute less than 0.5 per cent, and the most frequent x-ray examinations of the skeletal system, skull, cervical spine, and teeth account for less than 3 per cent. The GSD values obtained are comparable with those from countries such as India, Japan, Netherlands, USSR, and USA. (author)

Life paths and accomplishments of mathematically precocious males and females four decades later.

Science.gov (United States)

Lubinski, David; Benbow, Camilla P; Kell, Harrison J

2014-12-01

Two cohorts of intellectually talented 13-year-olds were identified in the 1970s (1972-1974 and 1976-1978) as being in the top 1% of mathematical reasoning ability (1,037 males, 613 females). About four decades later, data on their careers, accomplishments, psychological well-being, families, and life preferences and priorities were collected. Their accomplishments far exceeded base-rate expectations: Across the two cohorts, 4.1% had earned tenure at a major research university, 2.3% were top executives at "name brand" or Fortune 500 companies, and 2.4% were attorneys at major firms or organizations; participants had published 85 books and 7,572 refereed articles, secured 681 patents, and amassed $358 million in grants. For both males and females, mathematical precocity early in life predicts later creative contributions and leadership in critical occupational roles. On average, males had incomes much greater than their spouses', whereas females had incomes slightly lower than their spouses'. Salient sex differences that paralleled the differential career outcomes of the male and female participants were found in lifestyle preferences and priorities and in time allocation. © The Author(s) 2014.

Geotrap: radionuclide migration in geologic, heterogeneous media. Summary of accomplishments

International Nuclear Information System (INIS)

2002-01-01

GEOTRAP - the OECD/NEA Project on Radionuclide Migration in Geologic, Heterogeneous Media - was carried out in the context of site evaluation and safety assessment of deep repository systems for long-lived radioactive waste. The project was created in 1996 with the aim of developing an understanding of, and modelling capability for, potential radionuclide migration. This report provides an overview of the project's main findings and accomplishments over its five-year life. This summary should help make the valuable information collected and generated by the GEOTRAP project accessible to a wide readership both within and outside the radioactive waste community.It is a reflection of the careful attention paid by this community to the question of radionuclide transport. (authors)

Summary of the most significant results reported in this session

CERN Document Server

Sens, J C

1980-01-01

D1e most interesting although speculative result is the observation of a 4 standard deviation effect at 5. 3 GeV in the l)JK 0TI - and lj!K- 'ff+ mass plots (SPS Exp. WJ\\11) with a crosssection of 180 nb (assuming 1 % branching ratio). This is a cancliclatc bare b-state. + Tiw next most significant experimental result is the observation of Ac at the CERN Intersecting Storage Rings (ISR). TI1is state was discovered at BNL by Samios et al. and has since been seen in several neutrino experiments. It was seen at the ISR by Lockman ct al. about a year ago (reported at Budapest) but not in a convincing way. The analysis has now been improved, and the result shows a peak which is most clearly present in the stnnmed A(31T)+ and K-p1T+ mass spectra. 'TI1e signal has furthennore been seen in Exp. R606 (reported - + by F. Muller in this parallel session) in both A3TI and pK TI . 111e most convincing signal comes from the Spli t-Ficlcl Magnet (SFM) in K-pn + 'TI1e three observations together, all at the ISR, make this an...

Personalized citizen assistance for social participation (APIC): A promising intervention for increasing mobility, accomplishment of social activities and frequency of leisure activities in older adults having disabilities.

Science.gov (United States)

Levasseur, Mélanie; Lefebvre, Hélène; Levert, Marie-Josée; Lacasse-Bédard, Joanie; Desrosiers, Johanne; Therriault, Pierre-Yves; Tourigny, André; Couturier, Yves; Carbonneau, Hélène

2016-01-01

Social participation, a determinant of health in older adults, requires innovative interventions. The personalised citizen assistance for social participation (APIC) involves weekly three-hour personalised stimulation sessions targeting significant social and leisure activities difficult to accomplish. Recently adapted for older adults, the APIC's impact on this population is unknown. This study explored the impact of APIC on older adults with disabilities. A mixed-method design including a pre-experimental component was used with 16 participants (11 women) aged 66-91 (79.4±8.7) with disabilities, living at home. They completed functional autonomy, social participation, leisure and quality of life questionnaires, and semi-structured interviews. APIC increased older adults' functional autonomy (p=0.02), accomplishment (pleisure practice (pleisure activities, and difficulties in their social environment diminished (p=0.03). Their attitude toward leisure (p=0.04) as well as their health (p<0.01) and psychological (p=0.03) quality of life improved. Older adults thought APIC helped them resume, maintain, explore and experiment with significant social activities. It also increased their psychological and physical well-being, feeling of control, connectedness, self-esteem and motivation to accomplish activities. Finally, APIC can compensate for an unavailable and crumbling social network. APIC is a promising intervention that leads to new opportunities for older adults to increase community integration and enhance the social component of their lives. It can also optimise how the needs of older adults are met, including utilisation of personal and environmental resources. Crown Copyright © 2016. Published by Elsevier Ireland Ltd. All rights reserved.

Research accomplishments and future goals in particle physics

International Nuclear Information System (INIS)

1987-01-01

This document presents a report of the research accomplishments of Boston University researchers in six projects in high energy physics research: Study of high energy electron-positron annihilation, using the ASP and SLD detectors at SLAC; Search for proton decay and neutrinos from point astrophysical sources, as well as the study of cosmic ray muons and neutrinos in the IMB detector; Development of a new underground detector facility in the Gran Sasso Laboratory in Italy for magnetic monopoles and to study astrophysical muons and neutrinos; Preparation of an experiment to measure the anomalous magnetic moment of the muon in a new superconducting storage ring and detector system at BNL; Development of new concepts for particle accelerator components, including design and prototyping of high-precision electrostatic and magnetic elements; and Study of theoretical particle physics, including lattice gauge theories, string theories, phenomenology of the Standard Model and its extensions, and application of particle physics concepts to the early universe, cosmology and astrophysics, as well as the extension of these techniques into computational physics

The Global Geodetic Observing System: Recent Activities and Accomplishments

Science.gov (United States)

Gross, R. S.

2017-12-01

The Global Geodetic Observing System (GGOS) of the International Association of Geodesy (IAG) provides the basis on which future advances in geosciences can be built. By considering the Earth system as a whole (including the geosphere, hydrosphere, cryosphere, atmosphere and biosphere), monitoring Earth system components and their interactions by geodetic techniques and studying them from the geodetic point of view, the geodetic community provides the global geosciences community with a powerful tool consisting mainly of high-quality services, standards and references, and theoretical and observational innovations. The mission of GGOS is: (a) to provide the observations needed to monitor, map and understand changes in the Earth's shape, rotation and mass distribution; (b) to provide the global frame of reference that is the fundamental backbone for measuring and consistently interpreting key global change processes and for many other scientific and societal applications; and (c) to benefit science and society by providing the foundation upon which advances in Earth and planetary system science and applications are built. The goals of GGOS are: (1) to be the primary source for all global geodetic information and expertise serving society and Earth system science; (2) to actively promote, sustain, improve, and evolve the integrated global geodetic infrastructure needed to meet Earth science and societal requirements; (3) to coordinate with the international geodetic services that are the main source of key parameters and products needed to realize a stable global frame of reference and to observe and study changes in the dynamic Earth system; (4) to communicate and advocate the benefits of GGOS to user communities, policy makers, funding organizations, and society. In order to accomplish its mission and goals, GGOS depends on the IAG Services, Commissions, and Inter-Commission Committees. The Services provide the infrastructure and products on which all contributions

Some History and Accomplishments of the IUSS

Science.gov (United States)

Brevik, Eric C.; Hartemink, Alfred E.

2013-04-01

Urban Soils) and three standing committees (Committee on awards and prizes, Committee on budget and finances, and Committee on statutes and byelaws). Membership in ISSS/IUSS increased from around 550 after WWII to over 60,000 today. The IUSS also provides Honorary Membership to soil scientists who have significant accomplishments in the field; to date 87 soil scientists have been so recognized from all over the globe. The IUSS is the most important global link to the world's leading soil science and soil scientists.

Accomplishments and challenges in development of an autonomous operation system

International Nuclear Information System (INIS)

Endou, A.; Saiki, A.; Yoshikawa, S.; Okusa, K.; Suda, K.

1994-01-01

The authors are studying an autonomous operation system for nuclear power plants in which AI plays key roles as an alternative of plant operators and traditional controllers. In contrast with past studies dedicated to assist the operators, the ultimate target of development of the autonomous operation system is to operate the nuclear plants by AI. To realize humanlike decision-making process by means of AI, the authors used a model-based approach from multiple viewpoints and methodology diversity. A hierarchical distributed cooperative multi-agent system configuration is adopted to allow to incorporate diversified methodologies and to dynamically reorganize system functions. In the present paper, accomplishments to date in the course of the development are described. Challenges for developing methodologies to attain dynamic reorganization are also addressed. (author)

Activities and Accomplishments in Various Domains: Relationships with Creative Personality and Creative Motivation in Adolescence

Science.gov (United States)

Hong, Eunsook; Peng, Yun; O'Neil, Harold F., Jr.

2014-01-01

This study examined relationships between five personal traits and adolescents' creative activities and accomplishments in five domains--music, visual arts, creative writing, science, and technology. Participants were 439 tenth graders (220 males and 219 females) in China. The relationships were examined using confirmatory factor analysis.…

p-Curve and Effect Size: Correcting for Publication Bias Using Only Significant Results.

Science.gov (United States)

Simonsohn, Uri; Nelson, Leif D; Simmons, Joseph P

2014-11-01

Journals tend to publish only statistically significant evidence, creating a scientific record that markedly overstates the size of effects. We provide a new tool that corrects for this bias without requiring access to nonsignificant results. It capitalizes on the fact that the distribution of significant p values, p-curve, is a function of the true underlying effect. Researchers armed only with sample sizes and test results of the published findings can correct for publication bias. We validate the technique with simulations and by reanalyzing data from the Many-Labs Replication project. We demonstrate that p-curve can arrive at conclusions opposite that of existing tools by reanalyzing the meta-analysis of the "choice overload" literature. © The Author(s) 2014.

Affordability as a discursive accomplishment in a changing National Health Service.

Science.gov (United States)

Russell, Jill; Greenhalgh, Trisha

2012-12-01

Health systems worldwide face the challenges of rationing. The English National Health Service (NHS) was founded on three core principles: universality, comprehensiveness, and free at the point of delivery. Yet patients are increasingly hearing that some treatments are unaffordable on the NHS. We considered affordability as a social accomplishment and sought to explore how those charged with allocating NHS resources achieved this in practice. We undertook a linguistic ethnography to examine the work practices of resource allocation committees in three Primary Care Trusts (PCTs) in England between 2005 and 2012, specifically deliberations over 'individual funding requests' (IFRs)--requests by patients and their doctors for the PCT to support a treatment not routinely funded. We collected and analysed a diverse dataset comprising policy documents, legal judgements, audio recordings, ethnographic field notes and emails from PCT committee meetings, interviews and a focus group with committee members. We found that the fundamental values of universality and comprehensiveness strongly influenced the culture of these NHS organisations, and that in this context, accomplishing affordability was not easy. Four discursive practices served to confer legitimacy on affordability as a guiding value of NHS health care: (1) categorising certain treatments as only eligible for NHS funding if patients could prove 'exceptional' circumstances; (2) representing resource allocation decisions as being not (primarily) about money; (3) indexical labelling of affordability as an ethical principle, and (4) recontextualising legal judgements supporting refusal of NHS treatment on affordability grounds as 'rational'. The overall effect of these discursive practices was that denying treatment to patients became reasonable and rational for an organisation even while it continued to espouse traditional NHS values. We conclude that deliberations about the funding of treatments at the margins of NHS

Recent Accomplishments and Future Directions in US Fusion Safety & Environmental Program

Energy Technology Data Exchange (ETDEWEB)

David A. Petti; Brad J. Merrill; Phillip Sharpe; L. C. Cadwallader; L. El-Guebaly; S. Reyes

2006-07-01

The US fusion program has long recognized that the safety and environmental (S&E) potential of fusion can be attained by prudent materials selection, judicious design choices, and integration of safety requirements into the design of the facility. To achieve this goal, S&E research is focused on understanding the behavior of the largest sources of radioactive and hazardous materials in a fusion facility, understanding how energy sources in a fusion facility could mobilize those materials, developing integrated state of the art S&E computer codes and risk tools for safety assessment, and evaluating S&E issues associated with current fusion designs. In this paper, recent accomplishments are reviewed and future directions outlined.

Job leaving intentions and occupation-related beliefs amongst preregistered dental nurses in Scotland: the mediating role of work engagement and personal accomplishment.

Science.gov (United States)

Forbes, Gillian; Freeman, Ruth; McCombes, Wendy; Humphris, Gerry

2014-02-01

To identify the job resource beliefs of preregistration dental nurses and subsequently investigate their relationship with work engagement, personal accomplishment and intention to leave amongst this occupational group in Scotland. A cross-sectional survey design was used. The Utrecht Work Engagement Scale, Personal accomplishment (a subscale of Maslach Burnout Inventory) and author-developed questions for job resource beliefs and intention to leave were the measuring instruments used. Two hundred and thirty-one dental nurses participated (82% response rate). Mean age was 25 and mean job tenure was 17.5 months. The job resource belief most valued was 'good working relationship'. A multiple mediated path analytical model was explored. Work engagement adjusted for job resource beliefs was very strongly negatively associated with intention to leave (-0.93). There was an indirect relationship between job resource beliefs and intention to leave (-0.28) mediated via work engagement and personal accomplishment. Dental nurses under training held job resource beliefs about their profession that were associated with work engagement, personal accomplishment and their stability of remaining in the job. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Replacing gasoline with corn ethanol results in significant environmental problem-shifting.

Science.gov (United States)

Yang, Yi; Bae, Junghan; Kim, Junbeum; Suh, Sangwon

2012-04-03

Previous studies on the life-cycle environmental impacts of corn ethanol and gasoline focused almost exclusively on energy balance and greenhouse gas (GHG) emissions and largely overlooked the influence of regional differences in agricultural practices. This study compares the environmental impact of gasoline and E85 taking into consideration 12 different environmental impacts and regional differences among 19 corn-growing states. Results show that E85 does not outperform gasoline when a wide spectrum of impacts is considered. If the impacts are aggregated using weights developed by the National Institute of Standards and Technology (NIST), overall, E85 generates approximately 6% to 108% (23% on average) greater impact compared with gasoline, depending on where corn is produced, primarily because corn production induces significant eutrophication impacts and requires intensive irrigation. If GHG emissions from the indirect land use changes are considered, the differences increase to between 16% and 118% (33% on average). Our study indicates that replacing gasoline with corn ethanol may only result in shifting the net environmental impacts primarily toward increased eutrophication and greater water scarcity. These results suggest that the environmental criteria used in the Energy Independence and Security Act (EISA) be re-evaluated to include additional categories of environmental impact beyond GHG emissions.

Investigating Essential Factors on Students' Perceived Accomplishment and Enjoyment and Intention to Learn in Web Development

Science.gov (United States)

Zhang, Yulei; Dang, Yan

2015-01-01

Web development is an important component in the curriculum of computer science and information systems areas. However, it is generally considered difficult to learn among students. In this study,we examined factors that could influence students' perceptions of accomplishment and enjoyment and their intention to learn in the web development…

Magnetic Gimbal Proof-of-Concept Hardware performance results

Science.gov (United States)

Stuart, Keith O.

1993-01-01

The Magnetic Gimbal Proof-of-Concept Hardware activities, accomplishments, and test results are discussed. The Magnetic Gimbal Fabrication and Test (MGFT) program addressed the feasibility of using a magnetic gimbal to isolate an Electro-Optical (EO) sensor from the severe angular vibrations induced during the firing of divert and attitude control system (ACS) thrusters during space flight. The MGFT effort was performed in parallel with the fabrication and testing of a mechanically gimballed, flex pivot based isolation system by the Hughes Aircraft Missile Systems Group. Both servo systems supported identical EO sensor assembly mockups to facilitate direct comparison of performance. The results obtained from the MGFT effort indicate that the magnetic gimbal exhibits the ability to provide significant performance advantages over alternative mechanically gimballed techniques.

Accelerator mass spectrometry - accomplishments and challenges

International Nuclear Information System (INIS)

Elmore, David

2002-01-01

Full text: AMS techniques and applications have advanced significantly since the first radiocarbon measurements in 1977. The list of nuclides in routine use includes 10 Be, 14 C, 26 Al, 36 Cl, 41 Ca, and 129 I. Cosmogenic radionuclides now have important applications in the study of earth surface processes and events. Recent biomedical studies include tracing aluminum as a toxic element and as an adjuvant in vaccines, radiocarbon as a tracer for tissue implants, and calcium loss from bones. Improvements in AMS performance for these and new nuclides result from automation, better ion sources, higher energies, and better isobar separation techniques

Sense of Accomplishment Is Modulated by a Proper Level of Instruction and Represented in the Brain Reward System.

Science.gov (United States)

Nakai, Tomoya; Nakatani, Hironori; Hosoda, Chihiro; Nonaka, Yulri; Okanoya, Kazuo

2017-01-01

Problem-solving can be facilitated with instructions or hints, which provide information about given problems. The proper amount of instruction that should be provided for learners is controversial. Research shows that tasks with intermediate difficulty induce the largest sense of accomplishment (SA), leading to an intrinsic motivation for learning. To investigate the effect of instructions, we prepared three instruction levels (No hint, Indirect hint, and Direct hint) for the same insight-problem types. We hypothesized that indirect instructions impose intermediate difficulty for each individual, thereby inducing the greatest SA per person. Based on previous neuroimaging studies that showed involvement of the bilateral caudate in learning and motivation, we expected SA to be processed in this reward system. We recruited twenty-one participants, and investigated neural activations during problem solving by functional magnetic resonance imaging (fMRI). We confirmed that the Indirect hint, which imposed intermediate difficulty, induced the largest SA among the three instruction types. Using fMRI, we showed that activations in the bilateral caudate and anterior cingulate cortex (ACC) were significantly modulated by SA. In the bilateral caudate, the indirect hint induced the largest activation, while the ACC seemed to reflect the difference between correct and incorrect trials. Importantly, such activation pattern was independent of notations (number or letter). Our results indicate that SA is represented in the reward system, and that the Indirect instruction effectively induces such sensation.

Radiation safety training for industrial irradiators: What are we trying to accomplish?

International Nuclear Information System (INIS)

Smith, M.A.

1998-01-01

Radiation safety training at an industrial irradiator facility takes a different approach than the traditional methods and topics used at other facilities. Where the more routine industrial radiation users focus on standard training topics of contamination control, area surveys, and the traditional dogma of time, distance, and shielding, radiation safety in an industrial irradiation facility must be centered on preventing accidents. Because the primary methods for accomplishing that goal are engineering approaches such as safety system interlocks, training provided to facility personnel should address system operation and emergency actions. This presents challenges in delivering radiation safety training to an audience of varied educational and technical background where little to no commercially available training material specific to this type of operation exists

Gene expression results in lipopolysaccharide-stimulated monocytes depend significantly on the choice of reference genes

Directory of Open Access Journals (Sweden)

Øvstebø Reidun

2010-05-01

Full Text Available Abstract Background Gene expression in lipopolysaccharide (LPS-stimulated monocytes is mainly studied by quantitative real-time reverse transcription PCR (RT-qPCR using GAPDH (glyceraldehyde 3-phosphate dehydrogenase or ACTB (beta-actin as reference gene for normalization. Expression of traditional reference genes has been shown to vary substantially under certain conditions leading to invalid results. To investigate whether traditional reference genes are stably expressed in LPS-stimulated monocytes or if RT-qPCR results are dependent on the choice of reference genes, we have assessed and evaluated gene expression stability of twelve candidate reference genes in this model system. Results Twelve candidate reference genes were quantified by RT-qPCR in LPS-stimulated, human monocytes and evaluated using the programs geNorm, Normfinder and BestKeeper. geNorm ranked PPIB (cyclophilin B, B2M (beta-2-microglobulin and PPIA (cyclophilin A as the best combination for gene expression normalization in LPS-stimulated monocytes. Normfinder suggested TBP (TATA-box binding protein and B2M as the best combination. Compared to these combinations, normalization using GAPDH alone resulted in significantly higher changes of TNF-α (tumor necrosis factor-alpha and IL10 (interleukin 10 expression. Moreover, a significant difference in TNF-α expression between monocytes stimulated with equimolar concentrations of LPS from N. meningitides and E. coli, respectively, was identified when using the suggested combinations of reference genes for normalization, but stayed unrecognized when employing a single reference gene, ACTB or GAPDH. Conclusions Gene expression levels in LPS-stimulated monocytes based on RT-qPCR results differ significantly when normalized to a single gene or a combination of stably expressed reference genes. Proper evaluation of reference gene stabiliy is therefore mandatory before reporting RT-qPCR results in LPS-stimulated monocytes.

Task III: UCSD/DIII-D/Textor FY-97-98 Accomplishments

International Nuclear Information System (INIS)

Boedo, J.A.

2000-01-01

OAK (B204) Task III: UCSD/DIII-D/Textor FY-97-98 Accomplishments. A comprehensive report on the physics of pump limiters and particularly, the characterization of ALT-II, was published in Nuclear Fusion, bringing the project to a closure. The performance of the toroidal pump limiter was characterized under full auxiliary heating of 7 MW of NBI and ICRH and full pumping, as stated in the project milestones. Relevant highlights are: (1) Pumping with ALT-II allows for density control. (2) The achieved exhaust efficiency is 4% during NBI operation and near 2% during OH or ICRH operation. (3) We have shown that an exhaust efficiency of 2% is sufficient to satisfy the ash removal requirements of fusion reactors. (4) The plasma particle efflux and the pumped flux both increase with density and heating power. (5) The particle confinement time is less than the energy confinement time by a factor of 4. In summary, pumped belt limiters could provide the density control and ash exhaust requirements of fusion reactors

Some differences between English and Romanian resultative constructions

Directory of Open Access Journals (Sweden)

Imola-Ágnes Farkas

2009-01-01

Full Text Available It is a generally accepted fact that Romance languages behave differently from English and other Germanic languages as far as the building of resultative constructions is concerned. The wide availability of resultatives in English is in sharp contrast with their less frequent occurrence in Romanian; not to mention the view according to which there are no such constructions in Romanian at all. In the present paper we focus our attention on some differences between the resultatives in English and Romanian. Most importantly, English resultatives can be built on activity, as well as accomplishment matrix verbs; whereas Romanian allows only resultatives built on accomplishment verbs. This approach is consonant with Kayne’s (2005 theory about the existence/non-existence of silent elements in the two (families of languages; we explain this difference between the two languages in terms of the presence/absence of a silent UP TO element.

Advanced Industrial Materials (AIM) Program: Compilation of project summaries and significant accomplishments, FY 1995

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-04-01

In many ways, the Advanced Industrial Materials (AIM) Program underwent a major transformation in Fiscal Year 1995 and these changes have continued to the present. When the Program was established in 1990 as the Advanced Industrial Concepts (AIC) Materials Program, the mission was to conduct applied research and development to bring materials and processing technologies from the knowledge derived from basic research to the maturity required for the end use sectors for commercialization. In 1995, the Office of Industrial Technologies (OIT) made radical changes in structure and procedures. All technology development was directed toward the seven ``Vision Industries`` that use about 80% of industrial energy and generated about 90% of industrial wastes. The mission of AIM has, therefore, changed to ``Support development and commercialization of new or improved materials to improve productivity, product quality, and energy efficiency in the major process industries.`` Though AIM remains essentially a National Laboratory Program, it is essential that each project have industrial partners, including suppliers to, and customers of, the seven industries. Now, well into FY 1996, the transition is nearly complete and the AIM Program remains reasonably healthy and productive, thanks to the superb investigators and Laboratory Program Managers. This report contains the technical details of some very remarkable work by the best materials scientists and engineers in the world. Subject areas covered are: advanced metals and composites; advanced ceramics and composites; polymers and biobased materials; and new materials and processes.

What do younger and older workers want to accomplish? Age-related differences in content and characteristics of occupational goals

NARCIS (Netherlands)

Zacher, Hannes; Degner, Manuela; Seevaldt, Robert; Frese, Michael; Luedde, Joerg

2009-01-01

Demographic changes necessitate that companies commit younger workers and motivate older workers through work design. Age-related differences in occupational goals should be taken into account when accomplishing these challenges. In this study, we investigated goal contents and goal characteristics

How Well Can Existing Software Support Processes Accomplish Sustainment of a Non-Developmental Item-Based Acquisition Strategy

Science.gov (United States)

2017-04-06

guidance to the PM regarding development and sustainment of software . The need for a strong application of software engineering principles is...on the battlefield by a government- developed network manager application . The configuration of this confluence of software will be jointly managed...How Well Can Existing Software -Support Processes Accomplish Sustainment of a Non- Developmental Item-Based Acquisition Strategy? Graciano

Low velocity gunshot wounds result in significant contamination regardless of ballistic characteristics.

Science.gov (United States)

Weinstein, Joseph; Putney, Emily; Egol, Kenneth

2014-01-01

Controversy exists among the orthopedic community regarding the treatment of gunshot injuries. No consistent treatment algorithm exists for treatment of low energy gunshot wound (GSW) trauma. The purpose of this study was to critically examine the wound contamination following low velocity GSW based upon bullet caliber and clothing fiber type found within the injury track. Four types of handguns were fired at ballistic gel from a 10-foot distance. Various clothing materials were applied (denim, cotton, polyester, and wool) circumferentially around the tissue agar in a loose manor. A total of 32 specimens were examined. Each caliber handgun was fired a minimum of 5 times into a gel. Regardless of bullet caliber there was gross contamination of the entire bullet track in 100% of specimens in all scenarios and for all fiber types. Furthermore, as would be expected, the degree of contamination appeared to increase as the size of the bullet increased. Low velocity GSWs result in significant contamination regardless of bullet caliber and jacket type. Based upon our results further investigation of low velocity GSW tracks is warranted. Further clinical investigation should focus on the degree to which debridement should be undertaken.

29 CFR 452.108 - Publication of results.

Science.gov (United States)

2010-07-01

... 29 Labor 2 2010-07-01 2010-07-01 false Publication of results. 452.108 Section 452.108 Labor... DISCLOSURE ACT OF 1959 Election Procedures; Rights of Members § 452.108 Publication of results. In any... one local, publication may be accomplished by posting on appropriate bulletin boards, or in a union...

Serving the Nation for Fifty Years: 1952 - 2002 Lawrence Livermore National Laboratory [LLNL], Fifty Years of Accomplishments

Science.gov (United States)

2002-01-01

For 50 years, Lawrence Livermore National Laboratory has been making history and making a difference. The outstanding efforts by a dedicated work force have led to many remarkable accomplishments. Creative individuals and interdisciplinary teams at the Laboratory have sought breakthrough advances to strengthen national security and to help meet other enduring national needs. The Laboratory's rich history includes many interwoven stories -- from the first nuclear test failure to accomplishments meeting today's challenges. Many stories are tied to Livermore's national security mission, which has evolved to include ensuring the safety, security, and reliability of the nation's nuclear weapons without conducting nuclear tests and preventing the proliferation and use of weapons of mass destruction. Throughout its history and in its wide range of research activities, Livermore has achieved breakthroughs in applied and basic science, remarkable feats of engineering, and extraordinary advances in experimental and computational capabilities. From the many stories to tell, one has been selected for each year of the Laboratory's history. Together, these stories give a sense of the Laboratory -- its lasting focus on important missions, dedication to scientific and technical excellence, and drive to made the world more secure and a better place to live.

Hipparcos: mission accomplished

Science.gov (United States)

1993-08-01

prime contractor was Matra Marconi Space (France), also responsible for the payload and the on-board software development: with Alenia (Italy) responsible for the procurement of the spacecraft, as well as integration and testing of the complete satellite. A total of 35 European firms were involved in the satellite construction. The satellite was launched by Ariane 4 on 8 August 1989. Hipparcos was named after the pioneer Greek astronomer Hipparchus who compiled a detailed star map in around 120 BC and, by comparing it with observations made by his predecessors, established that the Earth's rotation axis slowly changed its direction in space. The Hipparcos satellite carried out its measurements in a highly elliptical 10-hour orbit, ranging between 500 km and 36,000 km above the Earth's surface, resulting from non-functioning of the satellite's apogee boost motor shortly after launch. A redesign of the on-board attitude control system, and the addition of two more ground stations into the control network, nevertheless allowed ESA's operations team at ESOC (Darmstadt, Germany) to operate the satellite with close to full efficiency. For the 20-strong operations team at ESOC and the ground station teams in Perth (Australia), Goldstone (USA) and Kourou (French Guiana) the mission has been highly interesting, challenging and very demanding. "After more than three years of excellent performance, underlining the remarkable quality of the satellite's design and construction, it was showing its age in several areas" said Dietmar Heger, ESOC's Spacecraft Operations Manager for Hipparcos. "The orbit was subjected to very significant levels of high energy electron and proton radiation, much higher than those expected in its intended geostationary orbit. We cannot be surprised or disappointed that the satellite has finally ceased to function" he said. The scientific activities associated with the Hipparcos mission are under the responsibility of four European scientific teams

NASA Intelligent Systems Project: Results, Accomplishments and Impact on Science Missions

Science.gov (United States)

Coughlan, Joseph C.

2005-01-01

The Intelligent Systems Project was responsible for much of NASA's programmatic investment in artificial intelligence and advanced information technologies. IS has completed three major project milestones which demonstrated increased capabilities in autonomy, human centered computing, and intelligent data understanding. Autonomy involves the ability of a robot to place an instrument on a remote surface with a single command cycle. Human centered computing supported a collaborative, mission centric data and planning system for the Mars Exploration Rovers and data understanding has produced key components of a terrestrial satellite observation system with automated modeling and data analysis capabilities. This paper summarizes the technology demonstrations and metrics which quantify and summarize these new technologies which are now available for future Nasa missions.

Two Languages, Number One Authors: The Influence of Bilingual Upbringing on the Literary Accomplishments of Roald Dahl and Dr. Seuss

Directory of Open Access Journals (Sweden)

Ivana Marinić

2008-06-01

Full Text Available This paper focuses on the nature and impact of bilingual upbringing on cognitive development, thought and cultural experience of two bestselling authors, Roald Dahl and Theodor Seuss Geisel (Dr. Seuss. It argues that this bilingual upbringing resulted in a specific use of language in their literary accomplishments. Several segments from representative works by Dahl and Dr. Seuss are examined in order to reveal the stylistic particularities of the two authors, such as their original argot, word play, neologisms, the art of exaggeration and nonsense, as well as various aspects of metaphor. This is to show that bilingualism may be a decisive factor in creating a fruitful environment for the development of original and recognizable mode of written expression, which not only transcends cognitive and linguistic boundaries, but also cultural borderlines, resulting in the emergence of a new cultural artistic identity.

First results from core-edge parallel composition in the FACETS project.

Energy Technology Data Exchange (ETDEWEB)

Cary, J. R.; Candy, J.; Cohen, R. H.; Krasheninnikov, S.; McCune, D. C.; Estep, D. J.; Larson, J.; Malony, A. D.; Pankin, A.; Worley, P. H.; Carlsson, J. A.; Hakim, A. H.; Hamill, P.; Kruger, S.; Miah, M.; Muzsala, S.; Pletzer, A.; Shasharina, S.; Wade-Stein, D.; Wang, N.; Balay, S.; McInnes, L.; Zhang, H.; Casper, T.; Diachin, L. (Mathematics and Computer Science); (Tech-X Corp.); (General Atomics); (LLNL); (Univ. of California at San Diego); (Princeton Plasma Physics Lab.); (Colorado State Univ.); (ParaTools Inc.); (Lehigh Univ.); (ORNL)

2008-01-01

FACETS (Framework Application for Core-Edge Transport Simulations), now in its second year, has achieved its first coupled core-edge transport simulations. In the process, a number of accompanying accomplishments were achieved. These include a new parallel core component, a new wall component, improvements in edge and source components, and the framework for coupling all of this together. These accomplishments were a result of an interdisciplinary collaboration among computational physics, computer scientists, and applied mathematicians on the team.

First results from core-edge parallel composition in the FACETS project

Energy Technology Data Exchange (ETDEWEB)

Cary, J R; Carlsson, J A; Hakim, A H; Hamill, P; Kruger, S; Miah, M; Muzsala, S; Pletzer, A; Shasharina, S; Wade-Stein, D; Wang, N [Tech-X Corporation, Boulder, CO 80303 (United States); Candy, J [General Atomics, San Diego, CA 92186 (United States); Cohen, R H [Lawrence Livermore National Laboratory, Livermore, CA 94550 (United States); Krasheninnikov, S [University of California at San Diego, San Diego, CA 92093 (United States); McCune, D C [Princeton Plasma Physics Laboratory, Princeton, NJ 08543 (United States); Estep, D J [Colorado State University, Fort Collins, CO 80523 (United States); Larson, J [Argonne National Laboratory, Argonne, IL 60439 (United States); Malony, A D [ParaTools, Inc., Eugene, OR 97405 (United States); Pankin, A [Lehigh University, Bethlehem, PA 18015 (United States); Worley, P H [Oak Ridge National Laboratory, Oak Ridge, TN 37831 (United States)], E-mail: cary@txcorp.com (and others)

2008-07-15

FACETS (Framework Application for Core-Edge Transport Simulations), now in its second year, has achieved its first coupled core-edge transport simulations. In the process, a number of accompanying accomplishments were achieved. These include a new parallel core component, a new wall component, improvements in edge and source components, and the framework for coupling all of this together. These accomplishments were a result of an interdisciplinary collaboration among computational physics, computer scientists, and applied mathematicians on the team.

First results from core-edge parallel composition in the FACETS project

Energy Technology Data Exchange (ETDEWEB)

Cary, John R. [Tech-X Corporation; Candy, Jeff [General Atomics; Cohen, Ronald H. [Lawrence Livermore National Laboratory (LLNL); Krasheninnikov, Sergei [University of California, San Diego; McCune, Douglas [Princeton Plasma Physics Laboratory (PPPL); Estep, Donald J [Colorado State University, Fort Collins; Larson, Jay [Argonne National Laboratory (ANL); Malony, Allen [University of Oregon; Pankin, A. [Lehigh University, Bethlehem, PA; Worley, Patrick H [ORNL; Carlsson, Johann [Tech-X Corporation; Hakim, A H [Tech-X Corporation; Hamill, P [Tech-X Corporation; Kruger, Scott [Tech-X Corporation; Miah, Mahmood [Tech-X Corporation; Muzsala, S [Tech-X Corporation; Pletzer, Alexander [Tech-X Corporation; Shasharina, Svetlana [Tech-X Corporation; Wade-Stein, D [Tech-X Corporation; Wang, N [Tech-X Corporation; Balay, Satish [Argonne National Laboratory (ANL); McInnes, Lois [Argonne National Laboratory (ANL); Zhang, Hong [Argonne National Laboratory (ANL); Casper, T. A. [Lawrence Livermore National Laboratory (LLNL); Diachin, Lori [Lawrence Livermore National Laboratory (LLNL); Epperly, Thomas [Lawrence Livermore National Laboratory (LLNL); Rognlien, T. D. [Lawrence Livermore National Laboratory (LLNL); Fahey, Mark R [ORNL; Cobb, John W [ORNL; Morris, A [University of Oregon; Shende, Sameer [University of Oregon; Hammett, Greg [Princeton Plasma Physics Laboratory (PPPL); Indireshkumar, K [Tech-X Corporation; Stotler, D. [Princeton Plasma Physics Laboratory (PPPL); Pigarov, A [University of California, San Diego

2008-01-01

FACETS (Framework Application for Core-Edge Transport Simulations), now in its second year, has achieved its first coupled core-edge transport simulations. In the process, a number of accompanying accomplishments were achieved. These include a new parallel core component, a new wall component, improvements in edge and source components, and the framework for coupling all of this together. These accomplishments were a result of an interdisciplinary collaboration among computational physics, computer scientists, and applied mathematicians on the team.

The NASA Space Life Sciences Training Program: Accomplishments Since 2013

Science.gov (United States)

Rask, Jon; Gibbs, Kristina; Ray, Hami; Bridges, Desireemoi; Bailey, Brad; Smith, Jeff; Sato, Kevin; Taylor, Elizabeth

2017-01-01

The NASA Space Life Sciences Training Program (SLSTP) provides undergraduate students entering their junior or senior years with professional experience in space life science disciplines. This challenging ten-week summer program is held at NASA Ames Research Center. The primary goal of the program is to train the next generation of scientists and engineers, enabling NASA to meet future research and development challenges in the space life sciences. Students work closely with NASA scientists and engineers on cutting-edge research and technology development. In addition to conducting hands-on research and presenting their findings, SLSTP students attend technical lectures given by experts on a wide range of topics, tour NASA research facilities, participate in leadership and team building exercises, and complete a group project. For this presentation, we will highlight program processes, accomplishments, goals, and feedback from alumni and mentors since 2013. To date, 49 students from 41 different academic institutions, 9 staffers, and 21 mentors have participated in the program. The SLSTP is funded by Space Biology, which is part of the Space Life and Physical Sciences Research and Application division of NASA's Human Exploration and Operations Mission Directorate. The SLSTP is managed by the Space Biology Project within the Science Directorate at Ames Research Center.

The social organization of representations of history: the textual accomplishment of coming to terms with the past.

Science.gov (United States)

Tileagă, Cristian

2009-06-01

This paper is concerned with the social organization of collective memory and representations of history in the context of how post-communist democracies reckon with former regimes. It specifically centres on the textual accomplishment of coming to terms with the past in the 'Tismăneanu Report' condemning Communism in Romania. The focus is on how the Report displays and shapes the ideological contours of coming to terms with the past around a particular 'social representation' of history. Several constitutive features of the Report that facilitate bringing off a particular 'representation of history' are identified: (a) the construction of a practical framework for the inquiry as a matter of public concern and attention; (b) the production of 'Communism' as an empirical category with uniquely bound features; and (c) the structuring of time by bringing together a political agenda and national identity. The present argument tries to place representations of history (and coming to terms with the past) as something in need of constitution rather than simply relied on. It is suggested that a conception of coming to terms with the past as a textual accomplishment may lead to a fuller appreciation of the structure, function and salience of representations of history as integral part of moral/political/legal courses of action.

Nuclear Thermal Propulsion (NTP) Development Activities at the NASA Marshall Space Flight Center - 2006 Accomplishments

Science.gov (United States)

Ballard, Richard O.

2007-01-01

In 2005-06, the Prometheus program funded a number of tasks at the NASA-Marshall Space Flight Center (MSFC) to support development of a Nuclear Thermal Propulsion (NTP) system for future manned exploration missions. These tasks include the following: 1. NTP Design Develop Test & Evaluate (DDT&E) Planning 2. NTP Mission & Systems Analysis / Stage Concepts & Engine Requirements 3. NTP Engine System Trade Space Analysis and Studies 4. NTP Engine Ground Test Facility Assessment 5. Non-Nuclear Environmental Simulator (NTREES) 6. Non-Nuclear Materials Fabrication & Evaluation 7. Multi-Physics TCA Modeling. This presentation is a overview of these tasks and their accomplishments

Science and technology for a sustainable energy future: Accomplishments of the Energy Efficiency and Renewable Energy Program at Oak Ridge National Laboratory

Energy Technology Data Exchange (ETDEWEB)

Brown, M.A.; Vaughan, K.H.

1995-03-01

Accomplishments of the Energy Efficiency and Renewable Energy Program at the Oak Ridge National Laboratory are presented. Included are activities performed in the utilities, transportation, industrial, and buildings technology areas.

Task V of the IEA Photovoltaic Power Systems Program: Accomplishments and Activities

International Nuclear Information System (INIS)

Bower, Ward

1999-01-01

The International Energy Agency (IEA) is an energy forum for 24 industrialized countries and was established in 1974 as an autonomous body within the Organization for Economic Cooperation and Development (OECD). The IEA Photovoltaic Power Systems (PVPS) program implementing agreement was signed in 1993, and renewed for another five years in 1998. Twenty-two countries are collaborating under the auspices of the IEA in the PVPS to address common technical and informational barriers that often limit the rate at which photovoltaic technologies advance into the markets. Task V of the IEA PVPS is entitled ''Grid Interconnection of Building-Integrated and Other Dispersed Photovoltaic Power Systems.'' The task sponsored a workshop in September 1997 on grid-interconnection of photovoltaic systems and is planning a second workshop to address impacts of more penetration of dispersed systems into the utility grid. This paper will summarize the accomplishments of Task V over the last five years and will detail the planned work for the next three years

The Solar Thermal Design Assistance Center report of its activities and accomplishments in Fiscal Year 1993

Energy Technology Data Exchange (ETDEWEB)

Menicucci, D.F.

1994-03-01

The Solar Thermal Design Assistance Center (STDAC) at Sandia National Laboratories is a resource provided by the US Department of Energy`s Solar Thermal Program. Its major objectives are to accelerate the use of solar thermal systems through (a) direct technical assistance to users, (b) cooperative test, evaluation, and development efforts with private industry, and (c) educational outreach activities. This report outlines the major activities and accomplishments of the STDAC in Fiscal Year 1993. The report also contains a comprehensive list of persons who contacted the STDAC by telephone for information or technical consulting.

A Review: Passive System Reliability Analysis – Accomplishments and Unresolved Issues

Energy Technology Data Exchange (ETDEWEB)

Nayak, Arun Kumar, E-mail: arunths@barc.gov.in [Reactor Engineering Division, Reactor Design and Development Group, Bhabha Atomic Research Centre, Mumbai (India); Chandrakar, Amit [Homi Bhabha National Institute, Mumbai (India); Vinod, Gopika [Reactor Safety Division, Reactor Design and Development Group, Bhabha Atomic Research Centre, Mumbai (India)

2014-10-10

Reliability assessment of passive safety systems is one of the important issues, since safety of advanced nuclear reactors rely on several passive features. In this context, a few methodologies such as reliability evaluation of passive safety system (REPAS), reliability methods for passive safety functions (RMPS), and analysis of passive systems reliability (APSRA) have been developed in the past. These methodologies have been used to assess reliability of various passive safety systems. While these methodologies have certain features in common, but they differ in considering certain issues; for example, treatment of model uncertainties, deviation of geometric, and process parameters from their nominal values. This paper presents the state of the art on passive system reliability assessment methodologies, the accomplishments, and remaining issues. In this review, three critical issues pertaining to passive systems performance and reliability have been identified. The first issue is applicability of best estimate codes and model uncertainty. The best estimate codes based phenomenological simulations of natural convection passive systems could have significant amount of uncertainties, these uncertainties must be incorporated in appropriate manner in the performance and reliability analysis of such systems. The second issue is the treatment of dynamic failure characteristics of components of passive systems. REPAS, RMPS, and APSRA methodologies do not consider dynamic failures of components or process, which may have strong influence on the failure of passive systems. The influence of dynamic failure characteristics of components on system failure probability is presented with the help of a dynamic reliability methodology based on Monte Carlo simulation. The analysis of a benchmark problem of Hold-up tank shows the error in failure probability estimation by not considering the dynamism of components. It is thus suggested that dynamic reliability methodologies must be

New ways of understanding and accomplishing leadership in academic medicine.

Science.gov (United States)

Souba, Wiley W

2004-04-01

Understanding leadership as being about a person in charge is not wrong, but it is no longer adequate. The challenges and problems confronting medicine today are so complex and unpredictable that it is practically impossible for one person to accomplish the work of leadership alone. More leadership requires more shared work, but as hospitals and medical centers begin to break down departmental barriers, people have to learn to work with individuals and groups who may have different work ethics, dissimilar styles of solving problems, or even contrasting values. Successful academic medical centers will make use of a broader repertoire of leadership strategies--besides developing leaders, they will develop leadership as a property of the system, as an organizational capacity. While leader development involves enhancing human (individual) capital, the emphasis in leadership development is on social capital and building more productive relationships that enhance networking, collaboration, and resource exchange. Leadership is created in and emerges from the relational space that connects people--accordingly, leadership development involves building high-quality connections between people. To make leadership happen more effectively, academic medical centers will have to identify and study the ingredients that catalyze and enhance human connectivity, augment social capital and activate leadership. Leadership is a uniquely human activity--studying it and how it works is core to the learning organization.

An accomplished teacher's use of scaffolding during a second-grade unit on designing games.

Science.gov (United States)

Chen, Weiyun; Rovegno, Inez; Cone, Stephen L; Cone, Theresa P

2012-06-01

The purpose of this study was to describe how an accomplished teacher taught second-grade students to design games that integrated movement and mathematics content. The participants were one physical education teacher; a classroom teacher, and an intact class of 20 second-grade students. Qualitative data were gathered through videotaping of all lessons, descriptions of 20 children's responses to all lesson segments, and interviews with all participants. In keeping with constructivist principles, the teacher used a progression of tasks and multiple instructional techniques to scaffold the design process allowing children to design games that were meaningful to them. Contrary to descriptions of scaffolding fading across a unit, in this study the scaffolding was a function of the interaction between learners' needs and task content.

[Formula: see text]Determination of the smoking gun of intent: significance testing of forced choice results in social security claimants.

Science.gov (United States)

Binder, Laurence M; Chafetz, Michael D

2018-01-01

Significantly below-chance findings on forced choice tests have been described as revealing "the smoking gun of intent" that proved malingering. The issues of probability levels, one-tailed vs. two-tailed tests, and the combining of PVT scores on significantly below-chance findings were addressed in a previous study, with a recommendation of a probability level of .20 to test the significance of below-chance results. The purpose of the present study was to determine the rate of below-chance findings in a Social Security Disability claimant sample using the previous recommendations. We compared the frequency of below-chance results on forced choice performance validity tests (PVTs) at two levels of significance, .05 and .20, and when using significance testing on individual subtests of the PVTs compared with total scores in claimants for Social Security Disability in order to determine the rate of the expected increase. The frequency of significant results increased with the higher level of significance for each subtest of the PVT and when combining individual test sections to increase the number of test items, with up to 20% of claimants showing significantly below-chance results at the higher p-value. These findings are discussed in light of Social Security Administration policy, showing an impact on policy issues concerning child abuse and neglect, and the importance of using these techniques in evaluations for Social Security Disability.

Environmental significance of atmospheric emission resulting from in situ burning of oiled salt marsh

International Nuclear Information System (INIS)

Devai, I.; DeLaune, R.D.; Henry, C.B. Jr.; Roberts, P.O.; Lindau, C.W.

1998-01-01

The environmental significance of atmospheric emissions resulting from in-situ burning used as remediation technique for removal of petroleum hydrocarbons entering Louisiana coastal salt marshes was quantified. Research conducted documented atmospheric pollutants produced and emitted to the atmosphere as the result of burning of oil contaminated wetlands. Samples collected from the smoke plume contained a variety of gaseous sulfur and carbon compounds. Carbonyl sulfide and carbon disulfide were the main volatile sulfur compounds. In contrast, concentrations of sulfur dioxide were almost negligible. Concentrations of methane and carbon dioxide in the smoke plume increased compared to ambient levels. Air samples collected for aromatic hydrocarbons in the smoke plume were dominated by pyrogenic or combustion derived aromatic hydrocarbons. The particulate fraction was dominated by phenanthrene and the C-1 and C-2 alkylated phenanthrene homologues. The vapor fraction was dominated by naphthalene and the C-1 to C-3 naphthalene homologues. (author)

Introduction to Urban and Community Forestry in the United States of America: History, Accomplishments, Issues and Trends

Institute of Scientific and Technical Information of China (English)

Qi Yadong; Zhang Zhiqiang

2003-01-01

The urban and community forestry movement in the United States has matured over the last 20 years from managing street trees, to understanding the benefits of trees in urban ecosystems, and now to managing urban green infrastructure. This paper introduced the history, development, and major accomplishments of the urban and community forestry movement, highlighted the economic, ecological, environmental, and social values of forests and trees to communities, and discussed issues and trends of the urban and community forestry program in the United States.

An initiative to improve the management of clinically significant test results in a large health care network.

Science.gov (United States)

Roy, Christopher L; Rothschild, Jeffrey M; Dighe, Anand S; Schiff, Gordon D; Graydon-Baker, Erin; Lenoci-Edwards, Jennifer; Dwyer, Cheryl; Khorasani, Ramin; Gandhi, Tejal K

2013-11-01

The failure of providers to communicate and follow up clinically significant test results (CSTR) is an important threat to patient safety. The Massachusetts Coalition for the Prevention of Medical Errors has endorsed the creation of systems to ensure that results can be received and acknowledged. In 2008 a task force was convened that represented clinicians, laboratories, radiology, patient safety, risk management, and information systems in a large health care network with the goals of providing recommendations and a road map for improvement in the management of CSTR and of implementing this improvement plan during the sub-force sequent five years. In drafting its charter, the task broadened the scope from "critical" results to "clinically significant" ones; clinically significant was defined as any result that requires further clinical action to avoid morbidity or mortality, regardless of the urgency of that action. The task force recommended four key areas for improvement--(1) standardization of policies and definitions, (2) robust identification of the patient's care team, (3) enhanced results management/tracking systems, and (4) centralized quality reporting and metrics. The task force faced many challenges in implementing these recommendations, including disagreements on definitions of CSTR and on who should have responsibility for CSTR, changes to established work flows, limitations of resources and of existing information systems, and definition of metrics. This large-scale effort to improve the communication and follow-up of CSTR in a health care network continues with ongoing work to address implementation challenges, refine policies, prepare for a new clinical information system platform, and identify new ways to measure the extent of this important safety problem.

Professional conceptualisation and accomplishment of patient safety in mental healthcare: an ethnographic approach

Directory of Open Access Journals (Sweden)

Braithwaite Jeffrey

2011-05-01

Full Text Available Abstract Background This study seeks to broaden current understandings of what patient safety means in mental healthcare and how it is accomplished. We propose a qualitative observational study of how safety is produced or not produced in the complex context of everyday professional mental health practice. Such an approach intentionally contrasts with much patient safety research which assumes that safety is achieved and improved through top-down policy directives. We seek instead to understand and articulate the connections and dynamic interactions between people, materials, and organisational, legal, moral, professional and historical safety imperatives as they come together at particular times and places to perform safe or unsafe practice. As such we advocate an understanding of patient safety 'from the ground up'. Methods/Design The proposed project employs a six-phase data collection framework in two mental health settings: an inpatient unit and a community team. The first four phases comprise multiple modes of focussed, unobtrusive observation of professionals at work, to enable us to trace the conceptualisation and enactment of safety as revealed in dialogue and narrative, use of artefacts and space, bodily activity and patterns of movement, and in the accomplishment of specific work tasks. An interview phase and a social network analysis phase will subsequently be conducted to offer comparative perspectives on the observational data. This multi-modal and holistic approach to studying patient safety will complement existing research, which is dominated by instrumentalist approaches to discovering factors contributing to error, or developing interventions to prevent or manage adverse events. Discussion This ethnographic research framework, informed by the principles of practice theories and in particular actor-network ideas, provides a tool to aid the understanding of patient safety in mental healthcare. The approach is novel in that it

Professional conceptualisation and accomplishment of patient safety in mental healthcare: an ethnographic approach

Science.gov (United States)

2011-01-01

Background This study seeks to broaden current understandings of what patient safety means in mental healthcare and how it is accomplished. We propose a qualitative observational study of how safety is produced or not produced in the complex context of everyday professional mental health practice. Such an approach intentionally contrasts with much patient safety research which assumes that safety is achieved and improved through top-down policy directives. We seek instead to understand and articulate the connections and dynamic interactions between people, materials, and organisational, legal, moral, professional and historical safety imperatives as they come together at particular times and places to perform safe or unsafe practice. As such we advocate an understanding of patient safety 'from the ground up'. Methods/Design The proposed project employs a six-phase data collection framework in two mental health settings: an inpatient unit and a community team. The first four phases comprise multiple modes of focussed, unobtrusive observation of professionals at work, to enable us to trace the conceptualisation and enactment of safety as revealed in dialogue and narrative, use of artefacts and space, bodily activity and patterns of movement, and in the accomplishment of specific work tasks. An interview phase and a social network analysis phase will subsequently be conducted to offer comparative perspectives on the observational data. This multi-modal and holistic approach to studying patient safety will complement existing research, which is dominated by instrumentalist approaches to discovering factors contributing to error, or developing interventions to prevent or manage adverse events. Discussion This ethnographic research framework, informed by the principles of practice theories and in particular actor-network ideas, provides a tool to aid the understanding of patient safety in mental healthcare. The approach is novel in that it seeks to articulate an 'anatomy

[False positive results or what's the probability that a significant P-value indicates a true effect?

Science.gov (United States)

Cucherat, Michel; Laporte, Silvy

2017-09-01

The use of statistical test is central in the clinical trial. At the statistical level, obtaining a Pinformation about the plausibility of the existence of treatment effect. With "Pfalse positive is very high. This is the case if the power is low, if there is an inflation of the alpha risk or if the result is exploratory or chance discoveries. This possibility is important to take into consideration when interpreting the results of clinical trials in order to avoid pushing ahead significant results in appearance, but which are likely to be actually false positive results. Copyright © 2017 Société française de pharmacologie et de thérapeutique. Published by Elsevier Masson SAS. All rights reserved.

How the detector resolution affects the clinical significance of SBRT pre-treatment quality assurance results.

Science.gov (United States)

Bruschi, A; Esposito, M; Pini, S; Ghirelli, A; Zatelli, G; Russo, S

2017-12-01

Aim of this work was to study how the detector resolution can affect the clinical significance of SBRT pre-treatment volumetric modulated arc therapy (VMAT) verification results. Three detectors (PTW OCTAVIUS 4D 729, 1500 and 100 SRS) used in five configurations with different resolution were compared: 729, 729 merged, 1500, 1500 merged and 1000 SRS. Absolute local gamma passing rates of 3D pre-treatment quality assurance (QA) were evaluated for 150 dose distributions in 30 plans. Five different kinds of error were introduced in order to establish the detection sensitivity of the three devices. Percentage dosimetric differences were evaluated between planned dosevolume histogram (DVH) and patients' predicted DVH calculated by PTW DVH 4D® software. The mean gamma passing rates and the standard deviations were 92.4% ± 3.7%, 94.6% ± 1.8%, 95.3% ± 4.2%, 97.4% ± 2.5% and 97.6% ± 1.4 respectively for 729, 729 merged, 1500, 1500 merged and 1000 SRS with 2% local dose/2mm criterion. The same trend was found on the sensitivity analysis: using a tight gamma analysis criterion (2%L/1mm) only the 1000 SRS detected every kind of error, while 729 and 1500 merged detected three and four kinds of error respectively. Regarding dose metrics extracted from DVH curves, D50% was within the tolerance level in more than 90% of cases only for the 1000 SRS. The detector resolution can significantly affect the clinical significance of SBRT pre-treatment verification results. The choice of a detector with resolution suitable to the investigated field size is of main importance to avoid getting false positive. Copyright © 2017 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

Evaluation of the accomplishment of the Brazilian regulation 'Portaria No. 453/98' in mammography X-ray sets installed in the Sergipe state, Brazil

International Nuclear Information System (INIS)

Rolemberg Silva, Fabio A.; Almeida de Novais, Adailton; Dantas Goes, Vera L.; Almeida Dantas, Marcelino V. de; Jesus Souza, Ericarla de; Oliveira Souza, Susana; Garrido Salmon, Carlos E.; Nascimento Souza, Divanizia do

2008-01-01

In this work was done an evaluation of the accomplishment of the regulation 'Portaria No. 453/98' of the Ministry of Health in mammography machine installed in the Sergipe state, Brazil. The quality control procedures were carried out in 23 equipments currently used in clinical routine. The testing methodologies are described in documents of two Brazilian institutions: ANVISA and Brazilian College of Radiology. The following results are expressed on percentage of equipments that were in conformity with minimum requirement of the regulation, considering separately the three kinds of the tests above mentioned. About mechanical parts: compression force (70%), coincidence between the radiation field and the radiographic film (80%) and distortion of the plate compression (47%). About image analysis: performance and reproducibility of the automatic exposure control (54% and 63% respectively), and image quality (84%). In the item beam radiation quality: reproducibility and linearity of the air rate kerma (100% and 84% respectively). In the automatic processors were monitored the following parameters: temperature (70%), pH (65%) and dry-to-dry processing time (25%). The unsatisfactory test results of the plate compression and automatic exposure control jeopardize the expected balance between dose distribution and image quality. This unbalance has significant effects on image nonuniformity and/or a localized dose increment. Even though the results of the tests of image quality and air Kerma rate can be considered satisfactory they are not enough for a full evaluation because they do not take into account the interaction with the object of interest: the breast. The results of the time processing suggest that the operators must change the parameters of the technique employed, attempting to maintain the image quality without resulting in an increase of the absorbed dose. (author)

Description of test facilities bound to the research on sodium aerosols - some significant results

Energy Technology Data Exchange (ETDEWEB)

Dolias, M; Lafon, A; Vidard, M; Schaller, K H [DRNR/STRS - Centre de Cadarache, Saint-Paul-lez-Durance (France)

1977-01-01

This communication is dedicated to the description of the CEA (French Atomic Energy Authority) testing located at CADARACHE and which are utilized for the study of sodium aerosols behavior. These testing loops are necessary for studying the operating of equipment such as filters, sodium vapour traps, condensers and separators. It is also possible to study the effect of characteristics parameters on formation, coagulation and carrying away of sodium aerosols in the cover gas. Sodium aerosols deposits in a vertical annular space configuration with a cold area in its upper part are also studied. Some significant results emphasize the importance of operating conditions on the formation of aerosols. (author)

Accomplishing the Visions for Teacher Education Programs Advocated in the National Science Education Standards

Science.gov (United States)

Akcay, Hakan; Yager, Robert

2010-10-01

The purpose of this study was to investigate the advantages of an approach to instruction using current problems and issues as curriculum organizers and illustrating how teaching must change to accomplish real learning. The study sample consisted of 41 preservice science teachers (13 males and 28 females) in a model science teacher education program. Both qualitative and quantitative research methods were used to determine success with science discipline-specific “Societal and Educational Applications” courses as one part of a total science teacher education program at a large Midwestern university. Students were involved with idea generation, consideration of multiple points of views, collaborative inquiries, and problem solving. All of these factors promoted grounded instruction using constructivist perspectives that situated science with actual experiences in the lives of students.

Research accomplishments and future goals in particle physics. Final technical report

International Nuclear Information System (INIS)

1994-06-01

This proposal presents the research accomplishments and ongoing activities of Boston University researchers in high energy physics. Some changes have been made in the structure of the program from the previous arrangement of tasks. Task B, Accelerator Design Physics, is being submitted as a separate proposal for an independent grant; this will be consistent with the nature of the research and the source of funding. Boston University is active in seven principal areas: (1) Task A: Colliding Beams -- physics of e + e - and anti pp collisions; (2) Task C: MACRO Experiment -- search for magnetic monopoles and study of cosmic rays; (3) Task D: Proton Decay -- search for nucleon instability and study of neutrino interactions; (4) Tasks E, J, and N: Particle Theory -- theoretical high energy particle physics, including two Outstanding Junior Investigator awards; (5) Task F: Muon G-2 -- measurement of the anomalous magnetic moment of the muon; (6) Task K: SSCintcal -- calorimetry for the GEM Experiment; (7) Task L: Muon Detectors for the GEM Experiment. The body of the proposal is devoted to detailed discussions of each of the tasks. The total budget request for the program appears in a summary chapter that includes a general budget discussion and individual budget requests and explanations for each of the tasks

Combat Ration Network for Technology Implementation. CORANET Demonstration Site: Results and Accomplishments

Science.gov (United States)

2010-01-01

School of Enviromental and Biological Sciences New Brunswick, NJ 08903 FTR 214 Defense Logistics Agency 8725 John J. Kingsman Rd Fort Belvoir, VA...Precision Automation X Injection Mold 1100 Rack Stock America X Injection Mold 1400 Rack AllPax X Enviromental Chamber Model: 11-679-25C Fisher

Managing for Results--Linking Performance Measures and Budgets.

Science.gov (United States)

McGee, William L.; Fountain, James R., Jr.

1995-01-01

The Government Accounting Standards Board notion of service efforts and accomplishments reporting is one step in a process of managing for results that includes strategic planning, development and use of performance measures of managing ongoing programs, and outputs to budgetary appropriation. Reports a trial application to one school district.…

Astrobiology at Arizona State University: An Overview of Accomplishments

Science.gov (United States)

Farmer, Jack

2005-01-01

During our five years as an NAI charter member, Arizona State University sponsored a broadly-based program of research and training in Astrobiology to address the origin, evolution and distribution of life in the Solar System. With such a large, diverse and active team, it is not possible in a reasonable space, to cover all details of progress made over the entire five years. The following paragraphs provide an overview update of the specific research areas pursued by the Arizona State University (ASU) Astrobiology team at the end of Year 5 and at the end of the 4 month and subsequent no cost month extensions. for a more detailed review, the reader is referred to the individual annual reports (and Executive Summaries) submitted to the NAI at the end of each of our five years of membership. Appended in electronic form is our complete publication record for all five years, plus a tabulation of undergraduates, graduate students and post-docs supported by our program during this time. The overarching theme of ASU s Astrobiology program was "Exploring the Living Universe: Studies of the Origin, Evolution and Distribution of Life in the Solar System". The NAi-funded research effort was organized under three basic sub- themes: 1. Origins of the Basic Building Blocks of Life. 2. Early Biosphere Evolution. and 3. Exploring for Life in the Solar System. These sub-theme areas were in turn, subdivided into Co-lead research modules. In the paragraphs that follow, accomplishments for individual research modules are briefly outlined, and the key participants presented in tabular form. As noted, publications for each module are appended in hard copy and digital formats, under the name(s) of lead co-Is.

Intensity-Modulated Radiotherapy Results in Significant Decrease in Clinical Toxicities Compared With Conventional Wedge-Based Breast Radiotherapy

International Nuclear Information System (INIS)

Harsolia, Asif; Kestin, Larry; Grills, Inga; Wallace, Michelle; Jolly, Shruti; Jones, Cortney; Lala, Moinaktar; Martinez, Alvaro; Schell, Scott; Vicini, Frank A.

2007-01-01

Purpose: We have previously demonstrated that intensity-modulated radiotherapy (IMRT) with a static multileaf collimator process results in a more homogenous dose distribution compared with conventional wedge-based whole breast irradiation (WBI). In the present analysis, we reviewed the acute and chronic toxicity of this IMRT approach compared with conventional wedge-based treatment. Methods and Materials: A total of 172 patients with Stage 0-IIB breast cancer were treated with lumpectomy followed by WBI. All patients underwent treatment planning computed tomography and received WBI (median dose, 45 Gy) followed by a boost to 61 Gy. Of the 172 patients, 93 (54%) were treated with IMRT, and the 79 patients (46%) treated with wedge-based RT in a consecutive fashion immediately before this cohort served as the control group. The median follow-up was 4.7 years. Results: A significant reduction in acute Grade 2 or worse dermatitis, edema, and hyperpigmentation was seen with IMRT compared with wedges. A trend was found toward reduced acute Grade 3 or greater dermatitis (6% vs. 1%, p = 0.09) in favor of IMRT. Chronic Grade 2 or worse breast edema was significantly reduced with IMRT compared with conventional wedges. No difference was found in cosmesis scores between the two groups. In patients with larger breasts (≥1,600 cm 3 , n = 64), IMRT resulted in reduced acute (Grade 2 or greater) breast edema (0% vs. 36%, p <0.001) and hyperpigmentation (3% vs. 41%, p 0.001) and chronic (Grade 2 or greater) long-term edema (3% vs. 30%, p 0.007). Conclusion: The use of IMRT in the treatment of the whole breast results in a significant decrease in acute dermatitis, edema, and hyperpigmentation and a reduction in the development of chronic breast edema compared with conventional wedge-based RT

Burnout in Cardiac Anesthesiologists: Results From a National Survey in Italy.

Science.gov (United States)

Sanfilippo, Filippo; Noto, Alberto; Palumbo, Gaetano J; Ippolito, Mariachiara; Gagliardone, Mariapia; Scarlata, Maria; Bignami, Elena; Sangalli, Fabio; Cattaneo, Sergio; Blangetti, Ilaria; Scolletta, Sabino; Locatelli, Alessandro; Tritapepe, Luigi; Lorini, Ferdinando L; Arcadipane, Antonio

2018-05-16

There is increasing burnout incidence among medical disciplines, and physicians working in emergency settings seem at higher risk. Cardiac anesthesiology is a stressful anesthesiology subspecialty dealing with high-risk patients. The authors hypothesized a high risk of burnout in cardiac anesthesiologists. National survey conducted on burnout SETTING: Italian cardiac centers. Cardiac anesthesiologists. The authors administered via email an anonymous questionnaire divided into 3 parts. The first 2 parts evaluated workload and private life. The third part consisted of the Maslach Burnout Inventory test with its 3 constituents: high emotional exhaustion, high depersonalization, and low personal accomplishment. The authors measured the prevalence and risk of burnout through the Maslach Burnout Inventory questionnaire and analyzed factors influencing burnout. Among 670 contacts from 71 centers, 382 cardiac anesthesiologists completed the survey (57%). The authors found the following mean Maslach Burnout Inventory values: 14.5 ± 9.7 (emotional exhaustion), 9.1 ± 7.1 (depersonalization), and 33.7 ± 8.9 (personal accomplishment). A rate of 34%, 54%, and 66% of respondents scored in "high" or "moderate-high" risk of burnout (emotional exhaustion, depersonalization, and personal accomplishment, respectively). The authors found that, if offered to change subspecialty, 76% of respondents would prefer to remain in cardiac anesthesiology. This preference and parenthood were the only 2 investigated factors with a protective effect against all components of burnout. Significantly lower burnout scores were found in more experienced anesthesiologists. A relatively high incidence of burnout was found in cardiac anesthesiologists, especially regarding high depersonalization and low personal accomplishment. Nonetheless, most of the respondents would choose to remain in cardiac anesthesiology. Copyright © 2018 Elsevier Inc. All rights reserved.

Safety Significance of the Halden IFA-650 LOCA Test Results

International Nuclear Information System (INIS)

Fuketa, Toyoshi; Nagase, Fumihisa; Grandjean, Claude; Petit, Marc; Hozer, Zoltan; Kelppe, Seppo; Khvostov, Grigori; Hafidi, Biya; Therache, Benjamin; Heins, Lothar; Valach, Mojmir; Voglewede, John; Wiesenack, Wolfgang

2010-01-01

CSNI therefore posed the question to the Working Group on Fuel Safety (WGFS): How could the Halden LOCA tests affect regulation? The WGFS agreed that the main safety concern would be fuel dispersal (and hence the potential for loss of coolable geometry) occurring at relatively low temperature, i.e. 800 deg. C. In order to assess the applicability of the IFA-650.4 results to actual power plant situations and the possible impact on safety criteria, a number of aspects should be clarified before considering a safety significance of the Halden IFA-650 series results: - Representativeness for NPP cases - Gas flow - Relocation - Burnup effect - Repeatability - Power history These items will be discussed one by one in this CSNI report. On April 17, 2009, test 650.9 was carried out with 650.4 sibling fuel. The target cladding peak temperature was 1100 deg. C in this case, but otherwise the experimental conditions were very similar. In many respects, 650.9 repeated the 650.4 experiment, e.g. by showing clear signs of fuel relocation which was confirmed by gamma scanning later on. The WGFS therefore decided that 650.9 should be considered as well for this CSNI report. Mention is also made of IFA-650.3, which failed with a small crack in a weak spot induced by thermocouple welding, and IFA-650.5 which involved ballooning and fuel ejection under conditions of restricted gas flow

"Disciplining witnesses" in the teaching of physiotherapy: some insights into the practical accomplishment of a science-based healthcare profession.

Science.gov (United States)

Kell, Clare; Horlick-Jones, Tom

2012-01-01

Physiotherapy in the UK defines itself as a "science-based healthcare profession". Physiotherapy students must undertake at least one thousand hours of learning in live practice settings. Adopting an analytic stance shaped by interaction analysis and workplace studies, and drawing on observational data of placement settings, this paper examines some features of the means by which physiotherapy education is practically accomplished. The paper introduces and utilises a novel notational system for capturing movement and touch in ethnographic fieldwork notes. Our analysis draws upon ideas from Lynch and Macbeth's (1998) study of elementary school science classes. We focus in particular on their notion of "disciplining witnesses" to illustrate how science is enacted -- and plays a privileged role -- within the everyday accomplishment of practice-based physiotherapy education. We show how patients are disciplined to provide information on cue and to act as props for therapeutic demonstrations, while students are disciplined to co-produce standard interpretations of the science of physiotherapy. We conclude the paper with a brief discussion of the ways in which these insights offer a new perspective for physiotherapy practitioners and educators in understanding the nature of interactions entailed in their professional practice, and the role of patients within those interactions.

A tribute to the life and accomplishments of Birdwell Finlayson.

Science.gov (United States)

Yeung, Lawrence L; Vieweg, Johannes W; Khan, Saeed R; Newman, Robert C; Dahm, Philipp

2008-03-01

Birdwell Finlayson was a talented researcher and clinician whose pioneering work in the field of urolithiasis led him to worldwide prominence in urology. We researched his life and accomplishments to provide a historical account of his career. The archives of the Department of Urology and the University of Florida Health Science Center Library were searched for publications, photographs and other records relating to Doctor Finlayson. Additionally, we interviewed many of his friends and colleagues for more information. Birdwell Finlayson was born in Pocatello Bannock, Idaho. He completed a urology residency and obtained a Ph.D. in biophysics at the University of Chicago. In 1967 he joined the faculty at the University of Florida. His interest in understanding the fundamentals of stone formation led to the discovery that crystal retention at a site of nephron injury was essential for stone formation. This fixed particle hypothesis continues to serve to as the foundation for urolithiasis research today. His computer model EQUIL is the gold standard for calculating urinary supersaturation with respect to kidney stone formation. Finlayson was 1 of the 6 original coinvestigators for shock wave lithotripsy in the United States. He is also remembered for his wit and his love of aeronautics, as he was a flight instructor and stunt pilot. Finlayson died unexpectedly of idiopathic hypertrophic cardiomyopathy on July 22, 1988. Birdwell Finlayson was an internationally renowned surgeon and stone disease expert whose research continues to serve as the basis of urolithiasis research at the University of Florida and worldwide.

Integrated Monitoring and Surveillance System demonstration project. Phase 2 accomplishments

International Nuclear Information System (INIS)

Aumeier, S.E.; Walters, B.G.; Singleterry, R.C.

1997-01-01

The paper presents the results of the Integrated Monitoring and Surveillance System (IMSS) demonstration project Phase 2 efforts. the rationale behind IMSS development is reviewed and progress in each of the 5 basic tasks is detailed. Significant results include further development of the data acquisition system and procurement of necessary hardware/software, options and associated costs for plutonium canning systems and gloveboxes, initiation of facility modifications, determination of possibly affected facility documentation, results from sensor system trade study, and preliminary storage configuration designs. Resources invested during Phase 1 and Phase 2 are summarized and budgetary requirements for completion of Phase 3 presented. The results show that the IMSS demonstration project team has met and in many cases exceeded the commitments made for Phase 2 deliverables

Design and accomplishment for the monitoring unit of the sup 6 sup 0 Co train freight inspection system

CERN Document Server

Cong Peng

2002-01-01

The sup 6 sup 0 Co railway cargo inspection system has super automaticity. And the monitoring unit is an important part of the automatic control system. The author introduces the idea of designing the monitoring unit in detail and accomplishes a new-style unit which is different from the traditional one. The monitoring unit which is highly integrated, easy to be mounted and debugged and convenient to be operated and maintained has play an excellent role in the work of the whole inspection system

The Seismic Category I Structures Program results for FY 1987

International Nuclear Information System (INIS)

Farrar, C.R.; Bennett, J.G.; Dunwoody, W.E.; Baker, W.E.

1990-10-01

The accomplishments of the Seismic Category I Structures Program for FY 1987 are summarized. These accomplishments include the quasi-static load cycle testing of large shear wall elements, an extensive analysis of previous data to determine if equivalent linear analytical models can predict the response of damaged shear wall structures, and code committee activities. In addition, previous testing and results that led to the FY 1987 program plan are discussed and all previous data relating to shear wall stiffness are summarized. Because separate reports have already summarized the experimental and analytical work in FY 1987, this report will briefly highlight this work and the appropriate reports will be references for a more detailed discussion. 12 refs., 23 figs., 18 tabs

Experience of research of valued-normative sphere of persons that accomplish felonious homicides from selfish motives

Directory of Open Access Journals (Sweden)

Ю. О. Оберемко

2015-11-01

Full Text Available Problem setting. The valued-normative sphere of consciousness of criminal’s personality is determined by views, persuasions, valued orientation, internal orientation, that altogether gives an opportunity to set reasons of the criminal behavior’s origin. Recent research and publications analysis. The deficiency of frequent researches of the mercenary killers’ personality, analysis of deformations of the axiological-normative sphere of their consciousness is actual for scientists. The question of axiological-normative sphere of criminal’s consciousness draw attention of many scientists, such as Yu. M. Antonyan, B. M. Golovkin, M.I. Enekeev, G.H. Efremova, K.E. Igoshev, A.R. Ratinov, O.M. Yakovlev. Paper main body. Consideration of personality of mercenary killer showed that one of leading morally-psychological lines of such persons a mercenary orientation comes forward. The aim of the article consists in consideration of criminal group, as forms of realization of mercenary orientation and criminogenic elements of consciousness of mercenary killer. The system of the valued orientations comes forward as an index of valued-normative sphere of personality of mercenary killer. It is considered that the valued orientations are regulator that inferior behavior of man. The presence of the different systems of values in society predetermines a wide choice the man of separate from them, as during the life she becomes the participant of many social relationships with the excellent valued structures. The analysis of the system of the valued orientations of mercenary killers we carried out on the basis of results of authorial empiric research. Investigating the psychological constituent of mercenary killers we paid attention to their emotionally-volitional features. We set that the volitional adjusting mercenary killers had at low level. It is persons that are characterized impulsiveness, mental instability and low level of self-control. Depending upon

Santa Rita Experimental Range: 100 years (1903 to 2003) of accomplishments and contributions; conference proceedings; 2003 October 30-November 1; Tucson, AZ

Science.gov (United States)

Mitchel P. McClaran; Peter F. Ffolliott; Carleton B. Edminster

2003-01-01

The purpose of this conference was to celebrate the 100 years of accomplishments and contributions of the Santa Rita Experimental Range, the longest continuously operating research area dedicated to the sustainable management of North American rangelands. The conference consisted of one-and-a-half days of invited synthesis papers and contributed poster presentations...

Pathways from parental stimulation of children's curiosity to high school science course accomplishments and science career interest and skill

Science.gov (United States)

Eskeles Gottfried, Adele; Johnson Preston, Kathleen Suzanne; Gottfried, Allen W.; Oliver, Pamella H.; Delany, Danielle E.; Ibrahim, Sirena M.

2016-08-01

Curiosity is fundamental to scientific inquiry and pursuance. Parents are important in encouraging children's involvement in science. This longitudinal study examined pathways from parental stimulation of children's curiosity per se to their science acquisition (SA). A latent variable of SA was indicated by the inter-related variables of high school science course accomplishments, career interest, and skill. A conceptual model investigated parental stimulation of children's curiosity as related to SA via science intrinsic motivation and science achievement. The Fullerton Longitudinal Study provided data spanning school entry through high school (N = 118). Parental stimulation of curiosity at age 8 years comprised exposing children to new experiences, promoting curiosity, encouraging asking questions, and taking children to a museum. Intrinsic motivation was measured at ages 9, 10, and 13 years, and achievement at ages 9, 10, and 11 years. Structural equation modelling was used for analyses. Controlling for socio-economic status, parental stimulation of curiosity bore positive and significant relations to science intrinsic motivation and achievement, which in turn related to SA. Gender neither related to stimulation of curiosity nor contributed to the model. Findings highlight the importance of parental stimulation of children's curiosity in facilitating trajectories into science, and relevance to science education is discussed.

PFR/TREAT program: objectives, accomplishments, and plans

International Nuclear Information System (INIS)

Cowking, C.B.; Alter, H.; Stillwell, J.; Wood, M.H.; Woods, W.J.; Culley, G.E.; Klickman, A.E.; Borys, S.S.

1984-01-01

The PFR-TREAT collaborative program of transient safety testing of fast reactor fuel was established in 1979 to provide mutual advantage to USDOE and the UKAEA through irradiation of US and UK full-length fuel pins in PFR, followed by safety testing in TREAT. The tests which were planned include Transient Over-Power (TOP) and Transient Under-Cooling with Over-Power (TUCOP) tests to fuel destruction and re-distribution; the results will provide significant new information on fuel and cladding behavior in hypothetical reactor faults. The information obtained in both US and UK fuel pins is to be interpreted by both partners and published jointly when mutually agreed. Thirteen tests, on fresh and irradiated fuel, in single-pin and 7-pin test sections, were completed by the end of 1983. The test matrix, which is currently being re-evaluated, calls for additional tests to be run under the present agreement. There has been an extensive program of post irradiation examination of sibling pins in both the UK and the US to characterize the test fuel prior to destructive irradiation, including testing of irradiated cladding to determine its failure characteristics

Integrated monitoring and surveillance system demonstration project: Phase I accomplishments

International Nuclear Information System (INIS)

Aumeier, S.E.; Walters, B.G.; Crawford, D.C.

1997-01-01

The authors present the results of the Integrated Monitoring and Surveillance System (IMSS) demonstration project Phase I efforts. The rationale behind IMSS development is reviewed and progress in each of the 5 basic tasks is detailed. Significant results include decisions to use Echelon LonWorks networking protocol and Microsoft Access for the data system needs, a preliminary design for the plutonium canning system glovebox, identification of facilities and materials available for the demonstration, determination of possibly affected facility documentation, and a preliminary list of available sensor technologies. Recently imposed changes in the overall project schedule and scope are also discussed and budgetary requirements for competition of Phase II presented. The results show that the IMSS demonstration project team has met and in many cases exceeded the commitments made for Phase I deliverables

Sigma Team for Advanced Actinide Recycle FY2015 Accomplishments and Directions

Energy Technology Data Exchange (ETDEWEB)

Moyer, Bruce A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2015-09-30

noncomplexing aqueous solution and submission of this scientific breakthrough as a paper in Science; The first-ever co-crystallization of Am(VI) with UO₂(NO₃)₂ ∙ 6H₂O, opening the door to a new approach for separating hexavalent actinides as a group; Results showing that three potentially problematic metals will not present risk in ALSEP; Improvement in ALSEP contactor stripping kinetics to acceptable performance; A comparison of centrifugal contactors vs mixer-settlers showing the former performs better in ALSEP stripping; Synthesis of new mixed N,O-donor extractants with enhanced solubility and strength for selective trivalent actinide extraction; Development of computational methods showing promise in prediction of the selectivity of new extractants for trivalent actinides vs lanthanides; An order-of-magnitude improvement in aqueous Am/Eu complexation selectivity of an alternative macrocyclic stripping agent for ALSEP, potentially enabling an option for an Am product stream free from both Ln and Cm. An alternative aqueous combination of dipicolinate complexant and malonate buffer that may present options for ALSEP and TALSPEAK (Trivalent Actinide-Lanthanide Separations by Phosphorus-reagent Extraction from Aqueous Komplexes) type separations. The ALSEP concept is advancing toward a benchtop flowsheet demonstration planned for FY 2016, and a bench-scale test bed at Idaho National Laboratory (INL) will be employed to demonstrate at least one tandem Am oxidation and separation concept. This report outlines the goals of the STAAR, significance of achieving these goals, STAAR organization around the above aims and questions, recent highlights, and future directions. The report also includes a listing of publications, reports, patents, and dissertations.

Web-based thyroid imaging reporting and data system: Malignancy risk of atypia of undetermined significance or follicular lesion of undetermined significance thyroid nodules calculated by a combination of ultrasonography features and biopsy results.

Science.gov (United States)

Choi, Young Jun; Baek, Jung Hwan; Shin, Jung Hee; Shim, Woo Hyun; Kim, Seon-Ok; Lee, Won-Hong; Song, Dong Eun; Kim, Tae Yong; Chung, Ki-Wook; Lee, Jeong Hyun

2018-05-13

The purpose of this study was to construct a web-based predictive model using ultrasound characteristics and subcategorized biopsy results for thyroid nodules of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) to stratify the risk of malignancy. Data included 672 thyroid nodules from 656 patients from a historical cohort. We analyzed ultrasound images of thyroid nodules and biopsy results according to nuclear atypia and architectural atypia. Multivariate logistic regression analysis was performed to predict whether nodules were diagnosed as malignant or benign. The ultrasound features, including spiculated margin, marked hypoechogenicity, calcifications, biopsy results, and cytologic atypia, showed significant differences between groups. A 13-point risk scoring system was developed, and the area under the curve (AUC) of the receiver operating characteristic (ROC) curve of the development and validation sets were 0.837 and 0.830, respectively (http://www.gap.kr/thyroidnodule_b3.php). We devised a web-based predictive model using the combined information of ultrasound characteristics and biopsy results for AUS/FLUS thyroid nodules to stratify the malignant risk. © 2018 Wiley Periodicals, Inc.

Calculation of limits for significant unidirectional changes in two or more serial results of a biomarker based on a computer simulation model

DEFF Research Database (Denmark)

Lund, Flemming; Petersen, Per Hyltoft; Fraser, Callum G

2015-01-01

BACKGROUND: Reference change values (RCVs) were introduced more than 30 years ago and provide objective tools for assessment of the significance of differences in two consecutive results from an individual. However, in practice, more results are usually available for monitoring, and using the RCV...... the presented factors. The first result is multiplied by the appropriate factor for increase or decrease, which gives the limits for a significant difference.......BACKGROUND: Reference change values (RCVs) were introduced more than 30 years ago and provide objective tools for assessment of the significance of differences in two consecutive results from an individual. However, in practice, more results are usually available for monitoring, and using the RCV......,000 simulated data from healthy individuals, a series of up to 20 results from an individual was generated using different values for the within-subject biological variation plus the analytical variation. Each new result in this series was compared to the initial measurement result. These successive serial...

Burnout: Job Resources and Job Demands Associated With Low Personal Accomplishment in United States Radiology Residents.

Science.gov (United States)

Guenette, Jeffrey P; Smith, Stacy E

2018-06-01

We aimed to identify job resources and job demands associated with measures of personal accomplishment (PA) in radiology residents in the United States. A 34-item online survey was administered between May and June 2017 to U.S. radiology residents and included the 8 Likert-type PA questions from the Maslach Burnout Inventory-Human Services Survey, 19 visual analog scale job demands-resources questions, and 7 demographic questions. Multiple linear regression was calculated to predict PA based on job demands-resources. Effects of binomial demographic factors on PA scores were compared with independent-samples t tests. Effects of categorical demographic factors on PA scores were compared with one-way between-subjects analysis of variance tests. A linear regression was calculated to evaluate the relationship of age on PA scores. "The skills and knowledge that I am building are important and helpful to society" (P = 2 × 10 -16 ), "I have good social support from my co-residents" (P = 4 × 10 -5 ), and "I regularly receive adequate constructive feedback" (P = 4 × 10 -6 ) all positively correlated with PA. PA scores were significantly lower for individuals who were single vs those married or partnered (P = .01). Radiology residents score higher in the PA domain of burnout when they receive adequate constructive feedback, have good co-resident social support, and feel that the skills and knowledge they are building are important to society. Improving constructive feedback mechanisms, enabling resident-only social time, and supporting opportunities that reinforce the importance of their contributions may therefore improve radiology residents' sense of PA. Copyright © 2018. Published by Elsevier Inc.

Introduction of e-learning in dental radiology reveals significantly improved results in final examination.

Science.gov (United States)

Meckfessel, Sandra; Stühmer, Constantin; Bormann, Kai-Hendrik; Kupka, Thomas; Behrends, Marianne; Matthies, Herbert; Vaske, Bernhard; Stiesch, Meike; Gellrich, Nils-Claudius; Rücker, Martin

2011-01-01

Because a traditionally instructed dental radiology lecture course is very time-consuming and labour-intensive, online courseware, including an interactive-learning module, was implemented to support the lectures. The purpose of this study was to evaluate the perceptions of students who have worked with web-based courseware as well as the effect on their results in final examinations. Users (n(3+4)=138) had access to the e-program from any networked computer at any time. Two groups (n(3)=71, n(4)=67) had to pass a final exam after using the e-course. Results were compared with two groups (n(1)=42, n(2)=48) who had studied the same content by attending traditional lectures. In addition a survey of the students was statistically evaluated. Most of the respondents reported a positive attitude towards e-learning and would have appreciated more access to computer-assisted instruction. Two years after initiating the e-course the failure rate in the final examination dropped significantly, from 40% to less than 2%. The very positive response to the e-program and improved test scores demonstrated the effectiveness of our e-course as a learning aid. Interactive modules in step with clinical practice provided learning that is not achieved by traditional teaching methods alone. To what extent staff savings are possible is part of a further study. Copyright © 2010 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

Analyzing the Competing Teams’ Match Results in 2012 - 2013 Season in Turki sh Spor Toto Super League Based on Different Parameters

Directory of Open Access Journals (Sweden)

Recep İMAMOĞLU

2015-08-01

Full Text Available The aim of the study is to evaluate the wins, draws, and defeats in the matches in Turkish Spor Toto Super League in 2012 - 2013 season based on different parameters that can influence the result. The data as a resource to the study has been obtained from the website tr.matchstudy.com which presents mat ch analyses by using Mathball software with 1,5% error margin rate. The data has been examined statistically by using SPSS 21.0 program and the significance level has been determined as p0.05 when the match scores of the teams such as w ins, draws, and defeats are compared with the percentage of ball possession in the attacking field. When the teams’ number of passes are viewed, it has been found out that losing teams accomplished more passes than the winning teams. Yet, these passes were negative ones which create a significant difference (p<0.05. As a result, it has been observed that the scores of the matches played between the teams are effected by the passes accomplished, the ball sent to the penalty area, and the shots to the goal. It has been revealed that losing teams have higher rates in some parameters such as passes and balls sent to the penalty area, but their attempts usually fail. It can be stated that the important point to win the game is not ball possession but to use the ball in a more effective and result - oriented way.

Status of selected ion flow tube MS: accomplishments and challenges in breath analysis and other areas.

Science.gov (United States)

Smith, David; Španěl, Patrik

2016-06-01

This article reflects our observations of recent accomplishments made using selected ion flow tube MS (SIFT-MS). Only brief descriptions are given of SIFT-MS as an analytical method and of the recent extensions to the underpinning analytical ion chemistry required to realize more robust analyses. The challenge of breath analysis is given special attention because, when achieved, it renders analysis of other air media relatively straightforward. Brief overviews are given of recent SIFT-MS breath analyses by leading research groups, noting the desirability of detection and quantification of single volatile biomarkers rather than reliance on statistical analyses, if breath analysis is to be accepted into clinical practice. A 'strengths, weaknesses, opportunities and threats' analysis of SIFT-MS is made, which should help to increase its utility for trace gas analysis.

The ACCOMPLISH study. A cluster randomised trial on the cost-effectiveness of a multicomponent intervention to improve hand hygiene compliance and reduce healthcare associated infections

Directory of Open Access Journals (Sweden)

Steyerberg Ewout W

2011-09-01

Full Text Available Abstract Background Public health authorities have recognized lack of hand hygiene in hospitals as one of the important causes of preventable mortality and morbidity at population level. The implementation strategy ACCOMPLISH (Actively Creating COMPLIance Saving Health targets both individual and environmental determinants of hand hygiene. This study aims to evaluate the cost-effectiveness of a multicomponent implementation strategy aimed at the reduction of healthcare associated infections in Dutch hospital care, by promotion of hand hygiene. Methods/design The ACCOMPLISH package will be evaluated in a two-arm cluster randomised trial in 16 hospitals in the Netherlands, in one intensive care unit and one surgical ward per hospital. Intervention A multicomponent package, including e-learning, team training, introduction of electronic alcohol based hand rub dispensers and performance feedback. Variables The primary outcome measure will be the observed hand hygiene compliance rate, measured at baseline and after 6, 12 and 18 months; as a secondary outcome measure the prevalence of healthcare associated infections will be measured at the same time points. Process indicators of the intervention will be collected pre and post intervention. An ex-post economic evaluation of the ACCOMPLISH package from a healthcare perspective will be performed. Statistical analysis Multilevel analysis, using mixed linear modelling techniques will be conducted to assess the effect of the intervention strategy on the overall compliance rate among healthcare workers and on prevalence of healthcare associated infections. Questionnaires on process indicators will be analysed with multivariable linear regression, and will include both behavioural determinants and determinants of innovation. Cost-effectiveness will be assessed by calculating the incremental cost-effectiveness ratio, defined here as the costs for the intervention divided by the difference in prevalence of

Initial results of the quality control in 11 computed tomography scanners at Curitiba

International Nuclear Information System (INIS)

Kodlulovich, S; Oliveira, L.; Jakubiak, R.R.; Miquelin, C.A.

2008-01-01

The aim of this study was to evaluate the image quality of 11 scanners installed in public and private centers of Curitiba, Brazil. This sample represents 30% of the CT scanners in the city so far. The ACR CT accreditation phantom was used to verify the accomplishment of the scanners performance to the international quality requirements. The results indicate that efforts should be concentrated in the maintenance of the equipments and specific training of the technicians. Most of the scanners have showed some non-conformity. In 27,5% of the sample the positioning requirement wasn't accomplished. The CT number accuracy evaluation showed that in 72,3 % of the scanners the CT numbers were out of the tolerance range, reaching values 35% greater than the limit. The low contrast resolution criteria weren't accomplished in 9% of the scanners. The main concern is that there isn't a specific program to evaluate the image quality of the CT scanners neither to estimate the CT doses in the procedures. (author)

The NEA thermochemical database project. 30 years of accomplishments

International Nuclear Information System (INIS)

Ragoussi, Maria-Eleni; Brassinnes, Stephane

2015-01-01

The NEA Thermochemical Database (TDB) Project (www.oecd-nea.org/dbtdb/) provides a database of chemical thermodynamic values treating the most significant elements related to nuclear waste management. The work carried out since the initiation of TDB in 1984 has resulted in the publication of thirteen major reviews and a large set of selected values that have become an international reference in the field, as they are characterized for their accuracy, consistency and high quality. Herein, we describe the basis, scientific principles and organization of the TDB project, together with its evolution from its inception to the present organization as a joint undertaking under Article 5(b) of the Statute of the OECD Nuclear Energy Agency (NEA).

[Effects of long-term isolation and anticipation of significant event on sleep: results of the project "Mars-520"].

Science.gov (United States)

Zavalko, I M; Rasskazova, E I; Gordeev, S A; Palatov, S Iu; Kovrov, G V

2013-01-01

The purpose of the research was to study effect of long-term isolation on night sleep. The data were collected during international ground simulation of an interplanetary manned flight--"Mars-500". The polysomnographic recordings of six healthy men were performed before, four times during and after 520-days confinement. During the isolation sleep efficiency and delta-latency decreased, while sleep latency increased. Post-hoc analysis demonstrate significant differences between background and the last (1.5 months before the end of the experiment) measure during isolation. Frequency of nights with low sleep efficiency rose on the eve of the important for the crew events (simulation of Mars landing and the end of the confinement). Two weeks after the landing simulation, amount of the nights with a low sleep efficiency significantly decreased. Therefore, anticipation of significant event under condition of long-term isolation might result in sleep worsening in previously healthy men, predominantly difficulties getting to sleep.

International space station accomplishments update: Scientific discovery, advancing future exploration, and benefits brought home to earth

Science.gov (United States)

Thumm, Tracy; Robinson, Julie A.; Alleyne, Camille; Hasbrook, Pete; Mayo, Susan; Buckley, Nicole; Johnson-Green, Perry; Karabadzhak, George; Kamigaichi, Shigeki; Umemura, Sayaka; Sorokin, Igor V.; Zell, Martin; Istasse, Eric; Sabbagh, Jean; Pignataro, Salvatore

2014-10-01

Throughout the history of the International Space Station (ISS), crews on board have conducted a variety of scientific research and educational activities. Well into the second year of full utilization of the ISS laboratory, the trend of scientific accomplishments and educational opportunities continues to grow. More than 1500 investigations have been conducted on the ISS since the first module launched in 1998, with over 700 scientific publications. The ISS provides a unique environment for research, international collaboration and educational activities that benefit humankind. This paper will provide an up to date summary of key investigations, facilities, publications, and benefits from ISS research that have developed over the past year. Discoveries in human physiology and nutrition have enabled astronauts to return from ISS with little bone loss, even as scientists seek to better understand the new puzzle of “ocular syndrome” affecting the vision of up to half of astronauts. The geneLAB campaign will unify life sciences investigations to seek genomic, proteomic and metabolomics of the effect of microgravity on life as a whole. Combustion scientists identified a new “cold flame” phenomenon that has the potential to improve models of efficient combustion back on Earth. A significant number of instruments in Earth remote sensing and astrophysics are providing new access to data or nearing completion for launch, making ISS a significant platform for understanding of the Earth system and the universe. In addition to multidisciplinary research, the ISS partnership conducts a myriad of student led research investigations and educational activities aimed at increasing student interest in science, technology, engineering and mathematics (STEM). Over the past year, the ISS partnership compiled new statistics of the educational impact of the ISS on students around the world. More than 43 million students, from kindergarten to graduate school, with more than 28

"What If" Analyses: Ways to Interpret Statistical Significance Test Results Using EXCEL or "R"

Science.gov (United States)

Ozturk, Elif

2012-01-01

The present paper aims to review two motivations to conduct "what if" analyses using Excel and "R" to understand the statistical significance tests through the sample size context. "What if" analyses can be used to teach students what statistical significance tests really do and in applied research either prospectively to estimate what sample size…

Intersystem LOCA risk assessment: methodology and results

International Nuclear Information System (INIS)

Galyean, W.J.; Kelly, D.L.; Schroeder, J.A.; Auflick, L.J.; Blackman, H.S.; Gertman, D.I.; Hanley, L.N.

1994-01-01

The United States Nuclear Regulatory Commission is sponsoring a research program to develop an improved understanding of the human factors, hardware and accident consequence issues that dominate the risk from an intersystem loss-of-coolant accident (ISLOCA) at a nuclear power plant. To accomplish the goals of this program, a mehtodology has been developed for estimating ISLOCA core damage frequency and risk. The steps in this methodology are briefly described, along with the results obtained from an application of the methodology at three pressurized water reactors. Also included are the results of a screening study of boiling water reactors. ((orig.))

The development and significance of the DOE Safeguards and Security standards and criteria

International Nuclear Information System (INIS)

Toman, J.

1987-01-01

In October 1985, the DOE Assistant Secretary for Defense Programs created a task force to develop inspection standards and criteria for Safeguards and Security. These standards and criteria (S/C) would provide the DOE Inspection and Evaluation (I and E) teams with the guidance needed to assess the security posture of DOE's nuclear and other important facilities. The Lawrence Livermore National Laboratory was designated the lead management organization for the structuring, administration, and execution of the overall task force effort and appointed the Executive Secretary. The Office of Security Evaluations (OSE) became the responsible DOE organization, and its Director assumed the role of Chairman of the Task Force Executive Committee. At its peak, the Task Force consisted of approximately 200 people who were considered to be experts in eight major topical areas. The composition of the experts was almost evenly divided between DOE and contractor employees. The collective wisdom of these experts was used in a consensus process to develop the S/C that are now published in draft form. These S/C have been used in more than ten inspections since May 1986 with much success. This paper discusses the process used to achieve the desired end result and the significance of the Task Force's accomplishments

Accounting for abortion: Accomplishing transnational reproductive governance through post-abortion care in Senegal.

Science.gov (United States)

Suh, Siri

2018-06-01

Reproductive governance operates through calculating demographic statistics that offer selective truths about reproductive practices, bodies, and subjectivities. Post-abortion care, a global reproductive health intervention, represents a transnational reproductive regime that establishes motherhood as women's primary legitimate reproductive status. Drawing on ethnographic fieldwork conducted in Senegal between 2010 and 2011, I illustrate how post-abortion care accomplishes reproductive governance in a context where abortion is prohibited altogether and the US is the primary bilateral donor of population aid. Reproductive governance unfolds in hospital gynecological wards and the national health information system through the mobilization and interpretation of post-abortion care data. Although health workers search women's bodies and behavior for signs of illegal abortion, they minimize police intervention in the hospital by classifying most post-abortion care cases as miscarriage. Health authorities deploy this account of post-abortion care to align the intervention with national and global maternal health policies that valorize motherhood. Although post-abortion care offers life-saving care to women with complications of illegal abortion, it institutionalizes abortion stigma by scrutinizing women's bodies and masking induced abortion within and beyond the hospital. Post-abortion care reinforces reproductive inequities by withholding safe, affordable obstetric care from women until after they have resorted to unsafe abortion.

The significance of the Sun, Moon and celestial bodies to societies in the Carpathian basin during the Bronze Age

Science.gov (United States)

Pásztor, Emília

2011-06-01

Celestial events often exerted a great or even decisive influence on the life of ancient communities. They may provide some of the foundations on which an understanding of the deeper meaning of mythologies, religious systems and even folk tales can be based. These influences are reflected and may be detected in the archaeological material as well. There is good evidence that celestial (especially solar and perhaps lunar) phenomena played a particularly important rôle in the worldview of prehistoric Europe. To reveal the social and ideational significance of concepts relating to the celestial bodies in the prehistory of the Carpathian Basin, complex investigations on orientations of houses and graves, prestige archaeological finds and iconography have been accomplished. The results indicate ideological and/or social changes, which developed into a likely organized ideological system in large part of Central Europe including the Carpathian Basin by the Late Bronze Age. It might also be the first period in prehistory when people became really interested in celestial phenomena.

Data bases for LDEF results

Science.gov (United States)

Bohnhoff-Hlavacek, Gail

1993-01-01

The Long Duration Exposure Facility (LDEF) carried 57 experiments and 10,000 specimens for some 200 LDEF experiment investigators. The external surface of LDEF had a large variety of materials exposed to the space environment which were tested preflight, during flight, and post flight. Thermal blankets, optical materials, thermal control paints, aluminum, and composites are among the materials flown. The investigations have produced an abundance of analysis results. One of the responsibilities of the Boeing Support Contract, Materials and Systems Special Investigation Group, is to collate and compile that information into an organized fashion. The databases developed at Boeing to accomplish this task is described.

Expression and clinical significance of PIWIL2 in hilar cholangiocarcinoma tissues and cell lines.

Science.gov (United States)

Chen, Y J; Xiong, X F; Wen, S Q; Tian, L; Cheng, W L; Qi, Y Q

2015-06-26

The objective of this study was to explore the relationship between PIWI-like protein 2 (PIWIL2) and clinicopathological charac-teristics and prognosis after radical resection. To accomplish this, we analyzed PIWIL2 expression in hilar cholangiocarcinoma tissues and cell lines. PIWIL2 expression was detected by immunohistochemistry in 41 hilar cholangiocarcinoma samples and 10 control tissues. Western blotting and immunocytofluorescence were used to investigate PIWIL2 expression in the cholangiocarcinoma cell line QBC939 and the bile duct epithelial cell line HIBEpic. Univariate and multivariate surviv-al analyses were performed using the Kaplan-Meier method for hilar cholangiocarcinoma patients who underwent radical resection. PIWIL2 expression was significantly higher in the hilar cholangiocarcinoma tissues and QBC939 cells than in control tissues and HIBEpic cells, respectively (P hilar cholangiocarcinoma (P hilar cholangiocarcinoma.

Most significant preliminary results of the probabilistic safety analysis on the Juragua nuclear power plant

International Nuclear Information System (INIS)

Perdomo, Manuel

1995-01-01

Since 1990 the Group for PSA Development and Applications (GDA/APS) is working on the Level-1 PSA for the Juragua-1 NPP, as a part of an IAEA Technical Assistance Project. The main objective of this study, which is still under way, is to assess, in a preliminary way, the Reactor design safety to find its potential 'weak points' at the construction stage, using a eneric data base. At the same time, the study allows the PSA team to familiarize with the plant design and analysis techniques for the future operational PSA of the plant. This paper presents the most significant preliminary results of the study, which reveal some advantages of the safety characteristics of the plant design in comparison with the homologous VVER-440 reactors and some areas, where including slight modifications would improve the plant safety, considering the level of detail at which the study is carried out. (author). 13 refs, 1 fig, 2 tabs

Potent corticosteroid cream (mometasone furoate) significantly reduces acute radiation dermatitis: results from a double-blind, randomized study

International Nuclear Information System (INIS)

Bostroem, Aasa; Lindman, Henrik; Swartling, Carl; Berne, Berit; Bergh, Jonas

2001-01-01

Purpose: Radiation-induced dermatitis is a very common side effect of radiation therapy, and may necessitate interruption of the therapy. There is a substantial lack of evidence-based treatments for this condition. The aim of this study was to investigate the effect of mometasone furoate cream (MMF) on radiation dermatitis in a prospective, double-blind, randomized study. Material and methods: The study comprised 49 patients with node-negative breast cancer. They were operated on with sector resection and scheduled for postoperative radiotherapy using photons with identical radiation qualities and dosage to the breast parenchyma. The patients were randomized to receive either MMF or emollient cream. The cream was applied on the irradiated skin twice a week from the start of radiotherapy until the 12th fraction (24 Gy) and thereafter once daily until 3 weeks after completion of radiation. Both groups additionally received non-blinded emollient cream daily. The intensity of the acute radiation dermatitis was evaluated on a weekly basis regarding erythema and pigmentation, using a reflectance spectrophotometer together with visual scoring of the skin reactions. Results: MMF in combination with emollient cream treatment significantly decreased acute radiation dermatitis (P=0.0033) compared with emollient cream alone. There was no significant difference in pigmentation between the two groups. Conclusions: Adding MMF, a potent topical corticosteroid, to an emollient cream is statistically significantly more effective than emollient cream alone in reducing acute radiation dermatitis

Superconducting solenoid model magnet test results

International Nuclear Information System (INIS)

Carcagno, R.; Dimarco, J.; Feher, S.; Ginsburg, C.M.; Hess, C.; Kashikhin, V.V.; Orris, D.F.; Pischalnikov, Y.; Sylvester, C.; Tartaglia, M.A.; Terechkine, I.; Tompkins, J.C.; Wokas, T.; Fermilab

2006-01-01

Superconducting solenoid magnets suitable for the room temperature front end of the Fermilab High Intensity Neutrino Source (formerly known as Proton Driver), an 8 GeV superconducting H- linac, have been designed and fabricated at Fermilab, and tested in the Fermilab Magnet Test Facility. We report here results of studies on the first model magnets in this program, including the mechanical properties during fabrication and testing in liquid helium at 4.2 K, quench performance, and magnetic field measurements. We also describe new test facility systems and instrumentation that have been developed to accomplish these tests

Superconducting solenoid model magnet test results

Energy Technology Data Exchange (ETDEWEB)

Carcagno, R.; Dimarco, J.; Feher, S.; Ginsburg, C.M.; Hess, C.; Kashikhin, V.V.; Orris, D.F.; Pischalnikov, Y.; Sylvester, C.; Tartaglia, M.A.; Terechkine, I.; /Fermilab

2006-08-01

Superconducting solenoid magnets suitable for the room temperature front end of the Fermilab High Intensity Neutrino Source (formerly known as Proton Driver), an 8 GeV superconducting H- linac, have been designed and fabricated at Fermilab, and tested in the Fermilab Magnet Test Facility. We report here results of studies on the first model magnets in this program, including the mechanical properties during fabrication and testing in liquid helium at 4.2 K, quench performance, and magnetic field measurements. We also describe new test facility systems and instrumentation that have been developed to accomplish these tests.

Predictors of systolic BP benazepril plus amlodipine or hydrochlorothiazide) in the ACCOMPLISH Study.

Science.gov (United States)

Kjeldsen, Sverre E; Jamerson, Kenneth A; Bakris, George L; Pitt, Bertram; Dahlöf, Björn; Velazquez, Eric J; Hua, Tsushung A; Kelly, Roxzana Y; Zappe, Dion; Hester, Allen; Tuomilehto, Jaakko; Ostergren, Jan; Ibsen, Hans; Weber, Michael

2012-04-01

The ACCOMPLISH Trial investigated intensive antihypertensive combination treatment with benazepril + amlodipine (B+A) or benazepril + hydrochlorothiazide (B+H) on cardiovascular outcomes in patients with systolic hypertension. We analyzed the baseline predictors of achieving a systolic blood pressure (SBP) Nordic region) and Caucasian ethnicity in both randomization arms. A higher diastolic BP and the use of lipid lowering agents indicated favorable effects in the B+H arm only. The predictors of uncontrolled SBP were: (i) higher baseline SBP values, (ii) higher number of previous antihypertensive medications in both arms, (iii) the previous use of insulin in the B+A arm, and (iv) pre-trial calcium channel blocker (CCB) use in the B+H arm. Additionally, pre-trial use of thiazides and electrocardiogram (ECG)-left ventricular hypertrophy (LVH) at baseline predicted higher, and smoking lower absolute SBP in the B+A arm and the use of thiazides and proteinuria a higher SBP in the B+H arm. Irrespective of treatment, patients in the USA and Caucasians achieved better SBP control, whereas higher baseline SBP and more previous antihypertensive medications indicated less control. Concomitant use of lipid lowering treatment indicated a better SBP control in the benazepril + hydrochlorothiazide arm. Lastly, insulin use and ECG-LVH in the benazepril + amlodipine arm and proteinuria in the benazepril + hydrochlorothiazide arm indicated poor control.

Salt decontamination demonstration test results

International Nuclear Information System (INIS)

Snell, E.B.; Heng, C.J.

1983-06-01

The Salt Decontamination Demonstration confirmed that the precipitation process could be used for large-scale decontamination of radioactive waste sale solution. Although a number of refinements are necessary to safely process the long-term requirement of 5 million gallons of waste salt solution per year, there were no observations to suggest that any fundamentals of the process require re-evaluation. Major accomplishments were: (1) 518,000 gallons of decontaminated filtrate were produced from 427,000 gallons of waste salt solution from tank 24H. The demonstration goal was to produce a minimum of 200,000 gallons of decontaminated salt solution; (2) cesium activity in the filtrate was reduced by a factor of 43,000 below the cesium activity in the tank 24 solution. This decontamination factor (DF) exceeded the demonstration goal of a DF greater than 10,000; (3) average strontium-90 activity in the filtrate was reduced by a factor of 26 to less than 10 3 d/m/ml versus a goal of less than 10 4 d/m/ml; and (4) the concentrated precipitate was washed to a final sodium ion concentration of 0.15 M, well below the 0.225 M upper limit for DWPF feed. These accomplishments were achieved on schedule and without incident. Total radiation exposure to personnel was less than 350 mrem and resulted primarily from sampling precipitate slurry inside tank 48. 3 references, 6 figures, 2 tables

Bone scintiscanning significance in breast cancer propaedeutics

Energy Technology Data Exchange (ETDEWEB)

de Almeida, J S; Fahel, V G; de Almeida, M R.M.; Hassan, A T; Hassan, E M.M.T. [Hospital Aristides Maltez, Salvador (Brazil). Servico de Medicina Nuclear

1977-01-01

An evaluation was performed of 139 bone scannings which were accomplished in patients with breast cancer. Bone scintigraphy was concluded to be more important than the radiological examination in this propedeutic. The increase of alkaline phosphatase was very significative too, since there was only one case in which it was increased and the bone scanning was negative and even so the liver scanning was positive. On the other hand there were cases which showed positive both bone scanning and radiological study although the alkaline phosphatase was not increase. The necessity of realizing this examination was emphazised even in initial cases, making possible to modify therapeutic shedules in time, to help patient.

National Low-Level Waste Management Program final summary report of key activities and accomplishments for fiscal year 1997

International Nuclear Information System (INIS)

Rittenberg, R.B.

1998-03-01

The US Department of Energy (DOE) has responsibilities under the Low-Level Radioactive Waste Policy Amendments Act of 1985 to assist states and compacts in their siting and licensing efforts for low-level radioactive waste disposal facilities. The National Low-Level Waste Management Program (NLLWMP) is the element of the DOE that performs the key support activities under the Act. The NLLWMP's activities are driven by the needs of the states and compacts as they prepare to manage their low-level waste under the Act. Other work is added during the fiscal year as necessary to accommodate new requests brought on by status changes in states' and compacts' siting and licensing efforts. This report summarizes the activities and accomplishments of the NLLWMP during FY 1997

The Evaluation of The Knowledge Levels and Attitudes of Medical Students Who Have Accomplished Obstetric and Gynaecological Diseases Internship in a Medical School About Human Papilloma Virus Vaccine

Directory of Open Access Journals (Sweden)

M. Fatih Onsuz

2011-10-01

Full Text Available Aim: Aim of the study was to determine medical school students’ knowledge levels and attitudes who accomplished Obstetric and Gynecology clerkship in a medical school about HPV vaccination and intention to suggest HPV vaccine to their patients. Method: This descriptive study was carried out in a medical school among 166 medical students accomplishing their internship in the Obstetrics and Gynaecological Diseases Department. Study data had been collected by questionnaire which had three part and 30 question. The data were evaluated by descriptive statistics. Results: Fifty five point four of the students stated that they felt informed about HPV vaccine, 72.9% of them stated that HPV was more serious for women. 95.8% of the participants thought they would suggest HPV vaccine to their patients and the most proposed group was adolescent girls (51.6%. 80.5% of students stated their possibility to suggest the vaccine would increase in case the vaccine would be free. The most important drawback points of the students in suggesting the vaccine to their patients were thinking high priced and not cost effectiveness of the vaccine (51.6% and inducing unprotected, risky sexual intercourses (45.9%. Conclusion: In this study we determine the professional acception of HPV vaccine between students. Also we determine the most important factor in suggesting the HPV vaccine is the cost effectiveness of it. [TAF Prev Med Bull 2011; 10(5.000: 557-564

An Evaluation of State Energy Program Accomplishments: 2002 Program Year

Energy Technology Data Exchange (ETDEWEB)

Schweitzer, M.

2005-07-13

cost savings and emissions reductions associated with SEP activities performed by the states during the 2002 program year, based on primary data provided by the states themselves. This is the second systematic evaluation of SEP accomplishments performed by Oak Ridge National Laboratory (ORNL) for DOE. A report documenting the findings of the first study was published in January 2003 (Schweitzer et.al., 2003).

Cell type-dependent induction of DNA damage by 1800 MHz radiofrequency electromagnetic fields does not result in significant cellular dysfunctions.

Directory of Open Access Journals (Sweden)

Shanshan Xu

Full Text Available BACKGROUND: Although IARC clarifies radiofrequency electromagnetic fields (RF-EMF as possible human carcinogen, the debate on its health impact continues due to the inconsistent results. Genotoxic effect has been considered as a golden standard to determine if an environmental factor is a carcinogen, but the currently available data for RF-EMF remain controversial. As an environmental stimulus, the effect of RF-EMF on cellular DNA may be subtle. Therefore, more sensitive method and systematic research strategy are warranted to evaluate its genotoxicity. OBJECTIVES: To determine whether RF-EMF does induce DNA damage and if the effect is cell-type dependent by adopting a more sensitive method γH2AX foci formation; and to investigate the biological consequences if RF-EMF does increase γH2AX foci formation. METHODS: Six different types of cells were intermittently exposed to GSM 1800 MHz RF-EMF at a specific absorption rate of 3.0 W/kg for 1 h or 24 h, then subjected to immunostaining with anti-γH2AX antibody. The biological consequences in γH2AX-elevated cell type were further explored with comet and TUNEL assays, flow cytometry, and cell growth assay. RESULTS: Exposure to RF-EMF for 24 h significantly induced γH2AX foci formation in Chinese hamster lung cells and Human skin fibroblasts (HSFs, but not the other cells. However, RF-EMF-elevated γH2AX foci formation in HSF cells did not result in detectable DNA fragmentation, sustainable cell cycle arrest, cell proliferation or viability change. RF-EMF exposure slightly but not significantly increased the cellular ROS level. CONCLUSIONS: RF-EMF induces DNA damage in a cell type-dependent manner, but the elevated γH2AX foci formation in HSF cells does not result in significant cellular dysfunctions.

THE INFLUENCE OF ACCOUNTING POLICIES OVER THE ENTITIES’ RESULT

Directory of Open Access Journals (Sweden)

ALICE EMILIA ŢINTA

2013-12-01

Full Text Available This article started from the idea that International Accounting and Financial Reporting Standards have had a major impact over the accounting world. Accounting laws of Continental Europe (especially France centered on historical cost, are in opposition to IFRS towards fair value. If accounting is based on historical cost we can say that excess of prudence leads to inaction. On the other hand the Anglo-Saxon accounting system is based on fair value that looks for a quick profit and to help investors. Financial statements record how resources have been handled by the management. The role of financial statements is to provide informations that will help users to make decisions. They can accomplish this mission only for those objectives that can be quantified as value and quantity. IFRS is referring to the whole set of financial statements that have to include a statement of the financial position, of the result, of changes in equity and treasury. Alongside these informations has to be a summary of significant accounting policies as well as informations about retrospective application of one or more accounting policies.

Analysis results from the Los Alamos 2D/3D program

International Nuclear Information System (INIS)

Boyack, B.E.; Cappiello, M.W.; Harmony, S.C.; Shire, P.R.; Siebe, D.A.

1987-01-01

Los Alamos National Laboratory is a participant in the 2D/3D program. Activities conducted at Los Alamos National Laboratory in support of 2D/3D program goals include analysis support of facility design, construction, and operation; provision of boundary and initial conditions for test-facility operations based on analysis of pressurized water reactors; performance of pretest and posttest predictions and analyses; and use of experimental results to validate and assess the single- and multi-dimensional, nonequilibrium features in the Transient Reactor Analysis Code (TRAC). During fiscal year 1987, Los Alamos conducted analytical assessment activities using data from the Slab Core Test Facility, The Cylindrical Core Test Facility, and the Upper Plenum Test Facility. Finally, Los Alamos continued work to provide TRAC improvements. In this paper, Los Alamos activities during fiscal year 1987 will be summarized; several significant accomplishments will be described in more detail to illustrate the work activities at Los Alamos

Mutagenicity in drug development: interpretation and significance of test results.

Science.gov (United States)

Clive, D

1985-03-01

The use of mutagenicity data has been proposed and widely accepted as a relatively fast and inexpensive means of predicting long-term risk to man (i.e., cancer in somatic cells, heritable mutations in germ cells). This view is based on the universal nature of the genetic material, the somatic mutation model of carcinogenesis, and a number of studies showing correlations between mutagenicity and carcinogenicity. An uncritical acceptance of this approach by some regulatory and industrial concerns is over-conservative, naive, and scientifically unjustifiable on a number of grounds: Human cancers are largely life-style related (e.g., cigarettes, diet, tanning). Mutagens (both natural and man-made) are far more prevalent in the environment than was originally assumed (e.g., the natural bases and nucleosides, protein pyrolysates, fluorescent lights, typewriter ribbon, red wine, diesel fuel exhausts, viruses, our own leukocytes). "False-positive" (relative to carcinogenicity) and "false-negative" mutagenicity results occur, often with rational explanations (e.g., high threshold, inappropriate metabolism, inadequate genetic endpoint), and thereby confound any straightforward interpretation of mutagenicity test results. Test battery composition affects both the proper identification of mutagens and, in many instances, the ability to make preliminary risk assessments. In vitro mutagenicity assays ignore whole animal protective mechanisms, may provide unphysiological metabolism, and may be either too sensitive (e.g., testing at orders-of-magnitude higher doses than can be ingested) or not sensitive enough (e.g., short-term treatments inadequately model chronic exposure in bioassay). Bacterial systems, particularly the Ames assay, cannot in principle detect chromosomal events which are involved in both carcinogenesis and germ line mutations in man. Some compounds induce only chromosomal events and little or no detectable single-gene events (e.g., acyclovir, caffeine

Bone scintiscanning significance in breast cancer propaedeutics

International Nuclear Information System (INIS)

Almeida, J.S. de; Fahel, V.G.; Almeida, M.R.M. de; Hassan, A.T.; Hassan, E.M.M.T.

1977-01-01

An evaluation was performed of 139 bone scannings which were accomplished in patients with breast cancer. Bone scintigraphy was concluded to be more important than the radiological examination in this propedeutic. The increase of alkaline phosphatase was very significative too, since there was only one case in which it was increased and the bone scanning was negative and even so the liver scanning was positive. On the other hand there were cases which showed positive both bone scanning and radiological study although the alkaline phosphatase was not increase. The necessity of realizing this examination was emphazised even in initial cases, making possible to modify therapeutic shedules in time, to help patient [pt

What is the clinical significance of chest CT when the chest x-ray result is normal in patients with blunt trauma?

Science.gov (United States)

Kea, Bory; Gamarallage, Ruwan; Vairamuthu, Hemamalini; Fortman, Jonathan; Lunney, Kevin; Hendey, Gregory W; Rodriguez, Robert M

2013-08-01

Computed tomography (CT) has been shown to detect more injuries than plain radiography in patients with blunt trauma, but it is unclear whether these injuries are clinically significant. This study aimed to determine the proportion of patients with normal chest x-ray (CXR) result and injury seen on CT and abnormal initial CXR result and no injury on CT and to characterize the clinical significance of injuries seen on CT as determined by a trauma expert panel. Patients with blunt trauma older than 14 years who received emergency department chest imaging as part of their evaluation at 2 urban level I trauma centers were enrolled. An expert trauma panel a priori classified thoracic injuries and subsequent interventions as major, minor, or no clinical significance. Of 3639 participants, 2848 (78.3%) had CXR alone and 791 (21.7%) had CXR and chest CT. Of 589 patients who had chest CT after a normal CXR result, 483 (82.0% [95% confidence interval [CI], 78.7-84.9%]) had normal CT results, and 106 (18.0% [95% CI, 15.1%-21.3%]) had CTs diagnosing injuries-primarily rib fractures, pulmonary contusion, and incidental pneumothorax. Twelve patients had injuries classified as clinically major (2.0% [95% CI, 1.2%-3.5%]), 78 were clinically minor (13.2% [95% CI, 10.7%-16.2%]), and 16 were clinically insignificant (2.7% (95% CI, 1.7%-4.4%]). Of 202 patients with CXRs suggesting injury, 177 (87.6% [95% CI, 82.4%-91.5%]) had chest CTs confirming injury and 25 (12.4% [95% CI, 8.5%-17.6%]) had no injury on CT. Chest CT after a normal CXR result in patients with blunt trauma detects injuries, but most do not lead to changes in patient management. Copyright © 2013 Elsevier Inc. All rights reserved.

Accomplishments in the Trident Laser Facility

Energy Technology Data Exchange (ETDEWEB)

Fernandez, Juan Carlos [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2016-08-25

Trident has been an extremely productive laser facility, despite its modest size and operating cost in the firmament of high-energy, high-power laser facilities worldwide. More than 150 peer-reviewed journal articles (in 39 different journals) have been published using Trident experimental data, many in high-impact journals such as Nature, Nature Physics, Nature Communications, and Physical Review Letters. More than 230 oral presentations involving research at Trident have been presented at national and international conferences. Trident publications have over 5000 citations in the literature with an h-index of 38. AT least 23 Los Alamos postdoctoral researchers have worked on Trident. In the period since its inception in 1992-2007, despite not issuing formal proposal calls for access nor functioning explicitly as a user facility until later, Trident has 170 unique users from more than 30 unique institutions, such as Los Alamos, Lawrence Livermore, and Sandia national laboratories, various University of California campuses, General Atomic, Imperial College, and Ecole Polytechnique. To reinforce its role as an important Los Alamos point of connection to the external research community, at least 20 PhD students did a significant fraction of their thesis work on Trident. Such PhD students include Mike Dunne (Imperial College, 1995) - now director of LCLS and professor at Stanford; David Hoarty (IC, 1997) - scientist at Atomic Weapons Establishment, UK; Dustin Froula (UC Davis, 2002) - Plasma and Ultrafast Physics Group leader at the Laboratory for Laser Energetics and assistant professor at the Physics and Astronomy Department at the University of Rochester; Tom Tierney (UC Irvine, 2002) - scientist at Los Alamos; Eric Loomis (Arizona State U., 2005) - scientist at Los Alamos; and Eliseo Gamboa (University of Michigan, 2013) - scientist at the Linac Coherent Light Source. The work performed on Trident, besides its scientific impact, has also supported the Inertial

Active Aging Promotion: Results from the Vital Aging Program

Directory of Open Access Journals (Sweden)

Mariagiovanna Caprara

2013-01-01

Full Text Available Active aging is one of the terms in the semantic network of aging well, together with others such as successful, productive, competent aging. All allude to the new paradigm in gerontology, whereby aging is considered from a positive perspective. Most authors in the field agree active aging is a multidimensional concept, embracing health, physical and cognitive fitness, positive affect and control, social relationships and engagement. This paper describes Vital Aging, an individual active aging promotion program implemented through three modalities: Life, Multimedia, and e-Learning. The program was developed on the basis of extensive evidence about individual determinants of active aging. The different versions of Vital Aging are described, and four evaluation studies (both formative and summative are reported. Formative evaluation reflected participants’ satisfaction and expected changes; summative evaluations yielded some quite encouraging results using quasi-experimental designs: those who took part in the programs increased their physical exercise, significantly improved their diet, reported better memory, had better emotional balance, and enjoyed more cultural, intellectual, affective, and social activities than they did before the course, thus increasing their social relationships. These results are discussed in the context of the common literature within the field and, also, taking into account the limitations of the evaluations accomplished.

Active aging promotion: results from the vital aging program.

Science.gov (United States)

Caprara, Mariagiovanna; Molina, María Ángeles; Schettini, Rocío; Santacreu, Marta; Orosa, Teresa; Mendoza-Núñez, Víctor Manuel; Rojas, Macarena; Fernández-Ballesteros, Rocío

2013-01-01

Active aging is one of the terms in the semantic network of aging well, together with others such as successful, productive, competent aging. All allude to the new paradigm in gerontology, whereby aging is considered from a positive perspective. Most authors in the field agree active aging is a multidimensional concept, embracing health, physical and cognitive fitness, positive affect and control, social relationships and engagement. This paper describes Vital Aging, an individual active aging promotion program implemented through three modalities: Life, Multimedia, and e-Learning. The program was developed on the basis of extensive evidence about individual determinants of active aging. The different versions of Vital Aging are described, and four evaluation studies (both formative and summative) are reported. Formative evaluation reflected participants' satisfaction and expected changes; summative evaluations yielded some quite encouraging results using quasi-experimental designs: those who took part in the programs increased their physical exercise, significantly improved their diet, reported better memory, had better emotional balance, and enjoyed more cultural, intellectual, affective, and social activities than they did before the course, thus increasing their social relationships. These results are discussed in the context of the common literature within the field and, also, taking into account the limitations of the evaluations accomplished.

Significant Tsunami Events

Science.gov (United States)

Dunbar, P. K.; Furtney, M.; McLean, S. J.; Sweeney, A. D.

2014-12-01

Tsunamis have inflicted death and destruction on the coastlines of the world throughout history. The occurrence of tsunamis and the resulting effects have been collected and studied as far back as the second millennium B.C. The knowledge gained from cataloging and examining these events has led to significant changes in our understanding of tsunamis, tsunami sources, and methods to mitigate the effects of tsunamis. The most significant, not surprisingly, are often the most devastating, such as the 2011 Tohoku, Japan earthquake and tsunami. The goal of this poster is to give a brief overview of the occurrence of tsunamis and then focus specifically on several significant tsunamis. There are various criteria to determine the most significant tsunamis: the number of deaths, amount of damage, maximum runup height, had a major impact on tsunami science or policy, etc. As a result, descriptions will include some of the most costly (2011 Tohoku, Japan), the most deadly (2004 Sumatra, 1883 Krakatau), and the highest runup ever observed (1958 Lituya Bay, Alaska). The discovery of the Cascadia subduction zone as the source of the 1700 Japanese "Orphan" tsunami and a future tsunami threat to the U.S. northwest coast, contributed to the decision to form the U.S. National Tsunami Hazard Mitigation Program. The great Lisbon earthquake of 1755 marked the beginning of the modern era of seismology. Knowledge gained from the 1964 Alaska earthquake and tsunami helped confirm the theory of plate tectonics. The 1946 Alaska, 1952 Kuril Islands, 1960 Chile, 1964 Alaska, and the 2004 Banda Aceh, tsunamis all resulted in warning centers or systems being established.The data descriptions on this poster were extracted from NOAA's National Geophysical Data Center (NGDC) global historical tsunami database. Additional information about these tsunamis, as well as water level data can be found by accessing the NGDC website www.ngdc.noaa.gov/hazard/

Overview and Recent Accomplishments of the Advanced Mirror Technology Development (AMTD) for Large Aperture UVOIR Space Telescopes Project

Science.gov (United States)

Stahl, H. Philip

2013-01-01

Per Astro2010, a new, larger UVO telescope is needed to answer fundamental scientific questions, such as: is there life on Earth-like exoplanets; how galaxies assemble stellar populations; how baryonic matter interacts with intergalactic medium; and how solar systems form and evolve. And, present technology is not mature enough to affordably build and launch any potential UVO concept. Advanced Mirror Technology Development (AMTD) is a funded SAT project. Our objective is to mature to TRL-6 the critical technologies needed to produce 4-m or larger flight-qualified UVOIR mirrors by 2018 so that a viable mission can be considered by the 2020 Decadal Review. AMTD uses a science-driven systems engineering approach. We mature technologies required to enable the highest priority science AND result in a high-performance low-cost low-risk system. To provide the science community with options, we are pursuing multiple technology paths. We have assembled an outstanding team from academia, industry, and government with extensive expertise in astrophysics and exoplanet characterization, and in the design/manufacture of monolithic and segmented space telescopes. One of our key accomplishments is that we have derived engineering specifications for advanced normal-incidence monolithic and segmented mirror systems needed to enable both general astrophysics and ultra-high contrast observations of exoplanets missions as a function of potential launch vehicle and its inherent mass and volume constraints. We defined and initiated a program to mature 6 key technologies required to fabricate monolithic and segmented space mirrors.

[The significance of the contamination of dental care articles. The results of a field study].

Science.gov (United States)

Hingst, V

1989-04-01

Permissible conclusions both from recent available literature and our own field-study results concerning the problematic nature of microbial contamination of dental hygiene articles and the resulting possible health hazard for the consumer can be summarized as follows: Manufacturing practices as are given in the basic instructions for production sites of the cosmetic industry, render a possible degree of microbial contamination. This largely rules out the danger of infection of the consumer upon acquisition of the dental hygiene product. Secondary contamination of these products, as inevitably is the case during use of dental hygiene articles, leads to microbial colonization especially of toothbrush bristles. The extent of this colonization depends at least partially upon the utilization age of the toothbrush. Also for this reason a toothbrush should be replaced by a new one after period of three months, six months at the latest and in all cases of inflammatory changes of the mouth and throat region. The contamination of both the glass or plastic container used for rinsing the teeth after brushing or for gargling can be held within certain limits by dry storage. Only in exceptional cases do mouthwashes show a small degree of contamination. Provided they contain antimicrobial substances, no therapeutically serviceable possibilities worth mentioning follow for the reduction of oropharyngeal flora. Microbial colonization of toothpastes as a result of secondary contamination following use is observed only in exceptional cases due to their preservative content. Significant germination of stagnated residual water in waterpicks often occurs, achieving germ counts up to more than 10(7) cfu per ml. Moreover, waterpicks can represent a biotope for Pseudomonas aeruginosa, and should be used neither by patients with open wounds or mucous membrane lesions in the oropharyngeal area, nor by patients with reduced immune resistance. Manufacturers of waterpicks are urged to impede

International Space Station Research for the Next Decade: International Coordination and Research Accomplishments

Science.gov (United States)

Thumm, Tracy L.; Robinson, Julie A.; Johnson-Green, Perry; Buckley, Nicole; Karabadzhak, George; Nakamura, Tai; Sorokin, Igor V.; Zell, Martin; Sabbagh, Jean

2011-01-01

During 2011, the International Space Station reached an important milestone in the completion of assembly and the shift to the focus on a full and continuous utilization mission in space. The ISS partnership itself has also met a milestone in the coordination and cooperation of utilization activities including research, technology development and education. We plan and track all ISS utilization activities jointly and have structures in place to cooperate on common goals by sharing ISS assets and resources, and extend the impacts and efficiency of utilization activities. The basic utilization areas on the ISS include research, technology development and testing, and education/outreach. Research can be categorized as applied research for future exploration, basic research taking advantage of the microgravity and open space environment, and Industrial R&D / commercial research focused at industrial product development and improvement. Technology development activities range from testing of new spacecraft systems and materials to the use of ISS as an analogue for future exploration missions to destinations beyond Earth orbit. This presentation, made jointly by all ISS international partners, will highlight the ways that international cooperation in all of these areas is achieved, and the overall accomplishments that have come as well as future perspectives from the cooperation. Recently, the partnership has made special efforts to increase the coordination and impact of ISS utilization that has humanitarian benefits. In this context the paper will highlight tentative ISS utilization developments in the areas of Earth remote sensing, medical technology transfer, and education/outreach.

Small-angle neutron scattering investigations of Co-doped iron oxide nanoparticles. Preliminary results

Science.gov (United States)

Creanga, Dorina; Balasoiu, Maria; Soloviov, Dmitro; Balasoiu-Gaina, Alexandra-Maria; Puscasu, Emil; Lupu, Nicoleta; Stan, Cristina

2018-03-01

Preliminary small-angle neutron scattering investigations on aqueous suspensions of several cobalt doped ferrites (CoxFe3-xO4, x=0; 0.5; 1) nanoparticles prepared by chemical co-precipitation method, are reported. The measurements were accomplished at the YuMO instrument in function at the IBR-2 reactor. Results of intermediary data treatment are presented and discussed.

Attentional Selection of Feature Conjunctions Is Accomplished by Parallel and Independent Selection of Single Features.

Science.gov (United States)

Andersen, Søren K; Müller, Matthias M; Hillyard, Steven A

2015-07-08

Experiments that study feature-based attention have often examined situations in which selection is based on a single feature (e.g., the color red). However, in more complex situations relevant stimuli may not be set apart from other stimuli by a single defining property but by a specific combination of features. Here, we examined sustained attentional selection of stimuli defined by conjunctions of color and orientation. Human observers attended to one out of four concurrently presented superimposed fields of randomly moving horizontal or vertical bars of red or blue color to detect brief intervals of coherent motion. Selective stimulus processing in early visual cortex was assessed by recordings of steady-state visual evoked potentials (SSVEPs) elicited by each of the flickering fields of stimuli. We directly contrasted attentional selection of single features and feature conjunctions and found that SSVEP amplitudes on conditions in which selection was based on a single feature only (color or orientation) exactly predicted the magnitude of attentional enhancement of SSVEPs when attending to a conjunction of both features. Furthermore, enhanced SSVEP amplitudes elicited by attended stimuli were accompanied by equivalent reductions of SSVEP amplitudes elicited by unattended stimuli in all cases. We conclude that attentional selection of a feature-conjunction stimulus is accomplished by the parallel and independent facilitation of its constituent feature dimensions in early visual cortex. The ability to perceive the world is limited by the brain's processing capacity. Attention affords adaptive behavior by selectively prioritizing processing of relevant stimuli based on their features (location, color, orientation, etc.). We found that attentional mechanisms for selection of different features belonging to the same object operate independently and in parallel: concurrent attentional selection of two stimulus features is simply the sum of attending to each of those

Hanford coring bit temperature monitor development testing results report

International Nuclear Information System (INIS)

Rey, D.

1995-05-01

Instrumentation which directly monitors the temperature of a coring bit used to retrieve core samples of high level nuclear waste stored in tanks at Hanford was developed at Sandia National Laboratories. Monitoring the temperature of the coring bit is desired to enhance the safety of the coring operations. A unique application of mature technologies was used to accomplish the measurement. This report documents the results of development testing performed at Sandia to assure the instrumentation will withstand the severe environments present in the waste tanks

The thresholds for statistical and clinical significance

DEFF Research Database (Denmark)

Jakobsen, Janus Christian; Gluud, Christian; Winkel, Per

2014-01-01

BACKGROUND: Thresholds for statistical significance are insufficiently demonstrated by 95% confidence intervals or P-values when assessing results from randomised clinical trials. First, a P-value only shows the probability of getting a result assuming that the null hypothesis is true and does...... not reflect the probability of getting a result assuming an alternative hypothesis to the null hypothesis is true. Second, a confidence interval or a P-value showing significance may be caused by multiplicity. Third, statistical significance does not necessarily result in clinical significance. Therefore...... of the probability that a given trial result is compatible with a 'null' effect (corresponding to the P-value) divided by the probability that the trial result is compatible with the intervention effect hypothesised in the sample size calculation; (3) adjust the confidence intervals and the statistical significance...

SPX significant events and whether it would have happened on EFR

International Nuclear Information System (INIS)

Rahmani, L.; Dechelette, S.; Bandini, C.

2000-01-01

In the 13 years since commissioning of the Creys-Malville nuclear power plant, exactly 100 unusual events were recorded on the French and later on the INES scales. The resultant ratio is slightly lower than the French PWR average. This is a noteworthy accomplishment, considering that the plant is a prototype, went through significant design changes, was repeatedly put to test in operating transients and, in addition, holds roughly twice the number of components as a PWR of comparable power. It may be inferred that fast reactors are not more difficult to operate than PWRs, which is also the opinion of most people having taken shifts in both types of reactors. Although Superphenix was labelled a white elephant by public opinion makers, this little known characteristic should remain part of its legacy. In this period 7 events are registered at the level 1 of the French and INES scales, owing either to misconception, material or operational failure. At the level 2 of the scales, 2 events are registered, which is admittedly quite high. The first one was the sodium leakage from and pervasive cracking of the revolving 'drum' of the fuel handling line, in retrospect the result of the choice of steel grade not fully compatible with sodium, which questions the designer's decision making process. The second level 2 event started as a massive air ingress in the primary circuit atmosphere, bringing on a pollution of the sodium up to 15,5 ppm of oxygen (although its significance in terms of corrosion was shown to be minimal). Although this event originated from a maintenance mix-up, it revealed a lack in understanding of sodium chemistry and the inadequacy of the instrumentation. The operational feed-back of the Superphenix reactor was thoroughly combed for clues to potential anomalies by a working group comprising representatives of the operator, utility, designer and R and D bodies. All the gathered information (together with experience gained from other FBRs, most notably PFR

Current results for the NRC's short cracks in piping and piping welds research program

International Nuclear Information System (INIS)

Wilkowski, G.; Krishnaswamy, P. Brust, F.; Francini, R.; Ghadiali, N.; Kilinski, T.; Marschall, C.; Rahman, S.; Rosenfield, A.; Scott, P.

1994-01-01

The overall objective of the Short Cracks in Piping and Piping Welds Program is to verify and improve engineering analyses to predict the fracture behavior of circumferentially cracked pipe under quasi-static loading with particular attention to crack lengths typically used in LBB or flaw evaluation criteria. The program consists of 8 technical tasks as listed below. Task 1 Short through-wall-cracked (TWC) pipe evaluations. Task 2 Short surface-cracked pipe evaluations. Task 3 Bi-metallic weld crack evaluations. Task 4 Dynamic strain aging and crack instabilities. Task 5 Fracture evaluations of anisotropic pipe. Task 6 Crack-opening-area evaluations. Task 7 NRCPIPE Code improvements. Task 8 Additional efforts. Since the last WRSM meeting several additional tasks have been initiated in this program. These are discussed in Task 8. Based on results to date, the first seven tasks have also been modified as deemed necessary. The most significant accomplishments in each of these tasks since the last WRSIM meeting are discussed below. The details of all the results presented here are published in the semiannual reports from this program

Analysis results from the Los Alamos 2D/3D program

International Nuclear Information System (INIS)

Boyack, B.E.; Cappiello, M.W.; Stumpf, H.; Shire, P.; Gilbert, J.; Hedstrom, J.

1986-01-01

Los Alamos National Laboratory is a participant in the 2D/3D program. Activities conducted at Los Alamos National Laboratory in support of 2D/3D program goals include analysis support of facility design, construction, and operation; provision of boundary and initial conditions for test facility operations based on analysis of pressurized water reactors; performance of pretest and posttest predictions and analyses; and use of experimental results to validate and assess the single- and multidimensional nonequilibrium features in the Transient Reactor Analysis Code (TRAC). During Fiscal Year 1986, Los Alamos conducted analytical assessment activities using data from the Cylindrical Core Test Facility and the Slab Core Test Facility. Los Alamos also continued to provide support analysis for the planning of Upper Plenum Test Facility experiments. Finally, Los Alamos either completed or is currently working on three areas of TRAC modeling improvement. In this paper, Los Alamos activities during Fiscal Year 1986 are summarized; several significant accomplishments are described in more detail to illustrate the work activities at Los Alamos

Investor Outlook: Significance of the Positive LCA2 Gene Therapy Phase III Results.

Science.gov (United States)

Schimmer, Joshua; Breazzano, Steven

2015-12-01

Spark Therapeutics recently reported positive phase III results for SPK-RPE65 targeting the treatment of visual impairment caused by RPE65 gene mutations (often referred to as Leber congenital amaurosis type 2, or LCA2, but may include other retinal disorders), marking an important inflection point for the field of gene therapy. The results highlight the ability to successfully design and execute a randomized trial of a gene therapy and also reinforce the potentially predictive nature of early preclinical and clinical data. The results are expected to pave the way for the first approved gene therapy product in the United States and should sustain investor interest and confidence in gene therapy for many approaches, including retina targeting and beyond.

Statistical significant changes in ground thermal conditions of alpine Austria during the last decade

Science.gov (United States)

Kellerer-Pirklbauer, Andreas

2016-04-01

Longer data series (e.g. >10 a) of ground temperatures in alpine regions are helpful to improve the understanding regarding the effects of present climate change on distribution and thermal characteristics of seasonal frost- and permafrost-affected areas. Beginning in 2004 - and more intensively since 2006 - a permafrost and seasonal frost monitoring network was established in Central and Eastern Austria by the University of Graz. This network consists of c.60 ground temperature (surface and near-surface) monitoring sites which are located at 1922-3002 m a.s.l., at latitude 46°55'-47°22'N and at longitude 12°44'-14°41'E. These data allow conclusions about general ground thermal conditions, potential permafrost occurrence, trend during the observation period, and regional pattern of changes. Calculations and analyses of several different temperature-related parameters were accomplished. At an annual scale a region-wide statistical significant warming during the observation period was revealed by e.g. an increase in mean annual temperature values (mean, maximum) or the significant lowering of the surface frost number (F+). At a seasonal scale no significant trend of any temperature-related parameter was in most cases revealed for spring (MAM) and autumn (SON). Winter (DJF) shows only a weak warming. In contrast, the summer (JJA) season reveals in general a significant warming as confirmed by several different temperature-related parameters such as e.g. mean seasonal temperature, number of thawing degree days, number of freezing degree days, or days without night frost. On a monthly basis August shows the statistically most robust and strongest warming of all months, although regional differences occur. Despite the fact that the general ground temperature warming during the last decade is confirmed by the field data in the study region, complications in trend analyses arise by temperature anomalies (e.g. warm winter 2006/07) or substantial variations in the winter

Technology benefits resulting from accelerator production of tritium

International Nuclear Information System (INIS)

1998-01-01

One of the early and most dramatic uses of nuclear transformations was in development of the nuclear weapons that brought World War II to an end. Despite that difficult introduction, nuclear weapons technology has been used largely as a deterrent to war throughout the latter half of the twentieth century. The Accelerator Production of Tritium (APT) offers a clean, safe, and reliable means of producing the tritium (a heavy form of hydrogen) needed to maintain the nuclear deterrent. Tritium decays away naturally at a rate of about 5.5% per year; therefore, the tritium reservoirs in nuclear weapons must be periodically replenished. In recent years this has been accomplished by recycling tritium from weapons being retired from the stockpile. Although this strategy has served well since the last US tritium production reactor was shut down in 1988, a new tritium production capability will be required within ten years. Some benefits will result from direct utilization of some of the APT proton beam; others could result from advances in the technologies of particle accelerators and high power spallation targets. The APT may save thousands of lives through the production of medical isotopes, and it may contribute to solving the nation's problem in disposing of long-lived nuclear wastes. But the most significant benefit may come from advancing the technology, so that the great potential of accelerator applications can be realized during our lifetimes

How significant is the ‘significant other’? Associations between significant others’ health behaviors and attitudes and young adults’ health outcomes

Directory of Open Access Journals (Sweden)

Berge Jerica M

2012-04-01

Full Text Available Abstract Background Having a significant other has been shown to be protective against physical and psychological health conditions for adults. Less is known about the period of emerging young adulthood and associations between significant others’ weight and weight-related health behaviors (e.g. healthy dietary intake, the frequency of physical activity, weight status. This study examined the association between significant others’ health attitudes and behaviors regarding eating and physical activity and young adults’ weight status, dietary intake, and physical activity. Methods This study uses data from Project EAT-III, a population-based cohort study with emerging young adults from diverse ethnic and socioeconomic backgrounds (n = 1212. Logistic regression models examining cross-sectional associations, adjusted for sociodemographics and health behaviors five years earlier, were used to estimate predicted probabilities and calculate prevalence differences. Results Young adult women whose significant others had health promoting attitudes/behaviors were significantly less likely to be overweight/obese and were more likely to eat ≥ 5 fruits/vegetables per day and engage in ≥ 3.5 hours/week of physical activity, compared to women whose significant others did not have health promoting behaviors/attitudes. Young adult men whose significant other had health promoting behaviors/attitudes were more likely to engage in ≥ 3.5 hours/week of physical activity compared to men whose significant others did not have health promoting behaviors/attitudes. Conclusions Findings suggest the protective nature of the significant other with regard to weight-related health behaviors of young adults, particularly for young adult women. Obesity prevention efforts should consider the importance of including the significant other in intervention efforts with young adult women and potentially men.

Statewide ban on recreational fires resulted in a significant decrease in campfire-related summer burn center admissions.

Science.gov (United States)

Hoang, David Manh; Reid, Dixie; Lentz, Christopher William

2013-01-01

Every summer, there is an increase in the number of burn injuries caused by accidents around campfires. Because of the prevalence of drought, high winds, and uncontrolled wild fires, a statewide ban on recreational fires was instituted in New Mexico from June to July 2011. We hypothesized that this legislation would have a significant impact on burn admissions caused by campfire-related injuries. A retrospective review of summer admissions to a state burn center was conducted to assess the effect of this ban on recreational fire injuries, and these data were compared with that of the previous summer when no ban was in effect. All burn admissions to a state burn center were reviewed from Memorial Day to Labor Day in 2010 and 2011. Data collected included cause, % TBSA, age, days of hospitalization, intensive care unit days, and total surface area grafted. Nonparametric statistical analysis was performed with Fisher exact test for dichotomous data and Mann-Whitney test for continuous data with significance at P fires during the study period (n = 14 [17%] in 2010 and 4 [5%] in 2011; P = .02). This resulted in a decrease in the number of patient-days from 91 in 2010 to 25 in 2011. Half of the camp fire admissions required skin grafts to definitively close the wounds (6/14 in 2010 and 2/4 in 2011). Recreational fire bans targeted at controlling wildfires during conditions favoring rapid spread were associated with a 3- to 4-fold decrease in campfire-related burn admissions. Compared with a summer when no fire ban was in effect, the number of patient-days decreased from 91 to 25.

The St.Petersburg school of oncogynecology, certain results and perspectives

International Nuclear Information System (INIS)

Bokhman, Ya.V.; Bishnevskij, A.S.; Maksimov, S.Ya.

1997-01-01

Basic results on studies, accomplished at the St.Petersburg school of oncogynecology, relative to the most frequent cases of Timor process localization (uterus cervix cancer, endometritis cancer, ovary cancer). It is shown that results of improved gynecological cancer treatment and decrease in mortality cases may be achieved not because of improving the surgical and radiation methods, the possibilities whereof are to a certain degree exhausted, but due to introduction of screening programs, enabling identification of early preclinical forms of cancer. Computerized and magnetoresonance tomography, USI and mammography are among the most efficient diagnostical methods. The perspectives of chemiohormone therapy and immunotherapy are also noted

Significance of isolated reactive treponemal chemiluminescence immunoassay results.

Science.gov (United States)

Hunter, Michael G; Robertson, Peter W; Post, Jeffrey J

2013-05-01

Isolated reactive serum treponemal chemiluminescence immunoassay (CIA) specimens cause clinical uncertainty. Sera were screened by CIA, and reactive samples underwent reflex testing with rapid plasma reagin (RPR), Treponema pallidum particle agglutination (TPPA), and fluorescent treponemal antibody absorption (FTA Abs) assays. Samples reactive only on the CIA were deemed "isolated" reactive CIA samples. We undertook detailed review of a subset of subjects with isolated reactive CIA specimens. Of 28 261 specimens, 1171 (4.1%) were reactive on CIA, of which 133 (11.3%) had isolated CIA reactivity. Most subjects (66 of 82 [80.5%]) with isolated reactive CIA specimens were from high-prevalence populations. We found evidence of CIA, TPPA, and FTA Abs seroreversion. The median chemiluminescent signal-to-cutoff ratio was similar for isolated reactive CIA sera and sera that were reactive on either FTA Abs or TPPA assays (2.19 vs 2.32; P = .15) but lower than for sera reactive on both FTA Abs and TPPA assays (12.37; P < .001) or for sera reactive on RPR assays (25.53; P < .001). A total of 11 of 20 patients (55%) with an isolated reactive CIA specimen who underwent medical record review had previous or subsequent evidence of syphilis infection. Isolated reactive CIA specimens may represent true T. pallidum infection and may be found after seroreversion of traditional treponemal assays.

U.S. ICF program: status and accomplishments

Science.gov (United States)

Crandall, D. H.; Keane, Christopher J.; Bieg, K.; Powers, L. V.; Sluyter, Marshall M.

1997-12-01

The paper describes the structure of the ICF program and highlights its latest results. The pre-construction activities of the National Ignition Facility (NIF) project have increased their momentum as a result of the recent Congressional decision to appropriate the requested funds for Fiscal Year 1997 to continue the project. The facility is an essential part of United States nuclear defense program in the absence of underground testing. The near-term goal of the U.S. ICF program is to achieve ignition in the laboratory (i.e. NIF) and to achieve high yield in the future. This paper describes some current results in ignition physics and related areas, as well as the progress in some new concepts that may have application to high yield. International collaborations that have been developed in recent years have contributed to the increased rate of progress. The paper closes with a summary of current and planned international initiatives.

Subintimal angioplasty for the treatment of long segment occlusion of superficial femoral artery: the midterm results

International Nuclear Information System (INIS)

Lou Wensheng; Gu Jianping; He Xu; Chen Liang; Chen Guoping; Su Haobo; Song Jinhua; Wang Tao; Xu Ke

2011-01-01

Objective: To discuss the clinical value of subintimal angioplasty in treating long segment occlusion of superficial femoral artery and to observe its midterm results. Methods: Subintimal angioplasty was performed in 45 patients with long segment occlusion of superficial femoral artery, whose clinical presentation was intermittent claudication or critical limb ischemia. The primary patency, limb salvage and factors influencing long-term patency were observed, and the clinical data were analyzed. Results: Of the total 45 cases, the subintimal angioplasty was successfully accomplished in 43. The success rate of antegrade approach technique via the superficial femoral artery was 80% (n=36), the occlusion was recanalized by using retrograde approach technique via ipsilateral popliteal artery in 7 case. The total technical success rate was 95.6%. The primary patency in 43 successful cases at 6, 12, 24 and 36 months was 85.7%, 69.0% 57.3% and 50.9%, respectively. No statistically significant difference in primary patency existed between the group of intermittent claudication and the group of critical limb ischemia (P>0.05). Statistically significant prediction factors for primary patency included the number of the run off vessels below the knee and the length of the occlusion (P<0.05). Conclusion: Subintimal angioplasty is an effective procedure for the treatment of long segment occlusions of superficial femoral artery with satisfactory mid-term results. (authors)

Women with provoked vestibulodynia experience clinically significant reductions in pain regardless of treatment: results from a 2-year follow-up study.

Science.gov (United States)

Davis, Seth N P; Bergeron, Sophie; Binik, Yitzchak M; Lambert, Bernard

2013-12-01

Provoked vestibulodynia (PVD) is a prevalent genital pain syndrome that has been assumed to be chronic, with little spontaneous remission. Despite this assumption, there is a dearth of empirical evidence regarding the progression of PVD in a natural setting. Although many treatments are available, there is no single treatment that has demonstrated efficacy above others. The aims of this secondary analysis of a prospective study were to (i) assess changes over a 2-year period in pain, depressive symptoms, and sexual outcomes in women with PVD; and (ii) examine changes based on treatment(s) type. Participants completed questionnaire packages at Time 1 and a follow-up package 2 years later. Visual analog scale of genital pain, Global Measure of Sexual Satisfaction, Female Sexual Function Index, Beck Depression Inventory, Dyadic Adjustment Scale, and sexual intercourse attempts over the past month. Two hundred thirty-nine women with PVD completed both time one and two questionnaires. For the sample as a whole, there was significant improvement over 2 years on pain ratings, sexual satisfaction, sexual function, and depressive symptoms. The most commonly received treatments were physical therapy, sex/psychotherapy, and medical treatment, although 41.0% did not undergo any treatment. Women receiving no treatment also improved significantly on pain ratings. No single treatment type predicted better outcome for any variable except depressive symptoms, in which women who underwent surgery were more likely to improve. These results suggest that PVD may significantly reduce in severity over time. Participants demonstrated clinically significant pain improvement, even when they did not receive treatment. Furthermore, the only single treatment type predicting better outcomes was surgery, and only for depressive symptoms, accounting for only 2.3% of the variance. These data do not demonstrate the superiority of any one treatment and underscore the need to have control groups in

Do US Ambient Air Lead Levels Have a Significant Impact on Childhood Blood Lead Levels: Results of a National Study

Directory of Open Access Journals (Sweden)

LuAnn L. Brink

2013-01-01

Full Text Available Introduction. Although lead paint and leaded gasoline have not been used in the US for thirty years, thousands of US children continue to have blood lead levels (BLLs of concern. Methods. We investigated the potential association of modeled air lead levels and BLLs ≥ 10 μg/dL using a large CDC database with BLLs on children aged 0–3 years. Percent of children with BLLs ≥ 10 μg/dL (2000–2007 by county and proportion of pre-50 housing and SES variables were merged with the US EPA's National Air Toxics Assessment (NATA modeled air lead data. Results. The proportion with BLL ≥ 10 μg/dL was 1.24% in the highest air lead counties, and the proportion with BLL ≥ 10 μg/dL was 0.36% in the lowest air lead counties, resulting in a crude prevalence ratio of 3.4. Further analysis using multivariate negative binomial regression revealed that NATA lead was a significant predictor of % BLL ≥ 10 μg/dL after controlling for percent pre-l950 housing, percent rural, and percent black. A geospatial regression revealed that air lead, percent older housing, and poverty were all significant predictors of % BLL ≥ 10 μg/dL. Conclusions. More emphasis should be given to potential sources of ambient air lead near residential areas.

2015 Accomplishments Report

Energy Technology Data Exchange (ETDEWEB)

None, None

2017-05-31

This report covers selected highlights from the four research pathways in the LWRS Program: Materials Aging and Degradation; Risk-Informed Safety Margin Characterization; Advanced Instrumentation, Information, and Control Systems Technologies; and Reactor Safety Technologies, as well as a look-ahead at planned activities for 2017.

2016 Accomplishments Report

Energy Technology Data Exchange (ETDEWEB)

None, None

2017-05-30

This report covers selected highlights from the four research pathways in the LWRS Program: Materials Aging and Degradation; Risk-Informed Safety Margin Characterization; Advanced Instrumentation, Information, and Control Systems Technologies; and Reactor Safety Technologies, as well as a look-ahead at planned activities for 2017.

2015 Accomplishments Report

International Nuclear Information System (INIS)

2017-01-01

This report covers selected highlights from the four research pathways in the LWRS Program: Materials Aging and Degradation; Risk-Informed Safety Margin Characterization; Advanced Instrumentation, Information, and Control Systems Technologies; and Reactor Safety Technologies, as well as a look-ahead at planned activities for 2017.

2016 Accomplishments Report

International Nuclear Information System (INIS)

2017-01-01

This report covers selected highlights from the four research pathways in the LWRS Program: Materials Aging and Degradation; Risk-Informed Safety Margin Characterization; Advanced Instrumentation, Information, and Control Systems Technologies; and Reactor Safety Technologies, as well as a look-ahead at planned activities for 2017.

Our Accomplishments | NREL

Science.gov (United States)

and financial performance of proposed projects well before the first shovel hits the dirt. NREL's performance models with detailed financial models to help stakeholders in the industry make informed decisions person viewing a simulation at the ESIF. Cool ride: thermal management boosts EV performance Cool ride

A result-driven minimum blocking method for PageRank parallel computing

Science.gov (United States)

Tao, Wan; Liu, Tao; Yu, Wei; Huang, Gan

2017-01-01

Matrix blocking is a common method for improving computational efficiency of PageRank, but the blocking rules are hard to be determined, and the following calculation is complicated. In tackling these problems, we propose a minimum blocking method driven by result needs to accomplish a parallel implementation of PageRank algorithm. The minimum blocking just stores the element which is necessary for the result matrix. In return, the following calculation becomes simple and the consumption of the I/O transmission is cut down. We do experiments on several matrixes of different data size and different sparsity degree. The results show that the proposed method has better computational efficiency than traditional blocking methods.

Biological significance of facilitated diffusion in protein-DNA interactions. Applications to T4 endonuclease V-initiated DNA repair

International Nuclear Information System (INIS)

Dowd, D.R.; Lloyd, R.S.

1990-01-01

Facilitated diffusion along nontarget DNA is employed by numerous DNA-interactive proteins to locate specific targets. Until now, the biological significance of DNA scanning has remained elusive. T4 endonuclease V is a DNA repair enzyme which scans nontarget DNA and processively incises DNA at the site of pyrimidine dimers which are produced by exposure to ultraviolet (UV) light. In this study we tested the hypothesis that there exists a direct correlation between the degree of processivity of wild type and mutant endonuclease V molecules and the degree of enhanced UV resistance which is conferred to repair-deficient Eshcerichia coli. This was accomplished by first creating a series of endonuclease V mutants whose in vitro catalytic activities were shown to be very similar to that of the wild type enzyme. However, when the mechanisms by which these enzymes search nontarget DNA for its substrate were analyzed in vitro and in vivo, the mutants displayed varying degrees of nontarget DNA scanning ranging from being nearly as processive as wild type to randomly incising dimers within the DNA population. The ability of these altered endonuclease V molecules to enhance UV survival in DNA repair-deficient E. coli then was assessed. The degree of enhanced UV survival was directly correlated with the level of facilitated diffusion. This is the first conclusive evidence directly relating a reduction of in vivo facilitated diffusion with a change in an observed phenotype. These results support the assertion that the mechanisms which DNA-interactive proteins employ in locating their target sites are of biological significance

Oral challenges with four apple cultivars result in significant differences in oral allergy symptoms.

Science.gov (United States)

Nybom, Hilde; Cervin-Hoberg, Charlotte; Andersson, Morgan

2013-01-01

We analyzed the hypoallergenic potential of a recently bred apple selection with unusually low content of Mal d 1, using an oral challenge model with three additional apple cultivars for comparison. Sixty-six birch pollen-allergic individuals with a history of oral allergy syndrome after apple intake were subjected to a double-blind oral provocation with two apple cultivars (B:0654 and 'Discovery'). Thirteen also tested two other apple cultivars ('Ingrid Marie' and 'Gloster'). Three doses were given consecutively, 30 min apart: 10 g without peel, and 10 and 50 g with peel. A final assessment was conducted 30 min after the last intake. Oral symptoms were graded from 0 to 5. Total oral symptom score (TOS) included all scores for each cultivar at all time points. B:0654 induced significantly higher TOS than 'Discovery' when tested by 66 individuals, in spite of its lower Mal d 1 content. TOS values were higher in females and increased with increasing age of the individuals when challenged with 'Discovery'. Among the 13 individuals who tested all four cultivars, B:0654 produced a higher score after the second dose compared to 'Ingrid Marie'. This was also the case after the third dose compared to 'Ingrid Marie' and 'Gloster', and again 30 min after the last intake compared to each of the other three cultivars, as well as a higher TOS compared to each of the other three cultivars (all p safe and well tolerated, and produced significant differences among the apple cultivars. Contrary to expectations, B:0654 was less well tolerated than the other three cultivars. Copyright © 2013 S. Karger AG, Basel.

Radiation exposure in the former uranium mining sites in Saxony and Thuringia. What was accomplished in 20 years of decontamination?; Strahlenexposition an ehemaligen Uranbergbau-Standorten in Sachsen und Thueringen. Was wurde in 20 Jahren Sanierung erreicht?

Energy Technology Data Exchange (ETDEWEB)

Schmidt, Peter [Wismuth GmbH, Chemnitz (Germany); Sperrhacke, Andrea [Saechsisches Landesamt fuer Umwelt, Landwirtschaft und Geologie, Dresden (Germany). Referat 54 - Natuerliche Radioaktivitaet

2012-07-01

The residuals of uranium mining and uranium ore processing ca results in considerable radiation exposures of the general public. Effective doses up to 20 mS/a are possible, especially if mine dumps, mines and industrial facilities were operated close to housing settlements, as has been the case for SDAG Wismut in Saxony and Thuringia. The activities of the radiation protection authorities have accomplished that the effective doses for the public of 1 mSv/a exceeded only very locally. The radiation protection goals will only be reached when the stability of spreading barriers in case of stored radioactive materials will be proven and the resulting radioactive concentration in aquifers and air will be faded out. The still existing radiation protection problems are summarized.

Preliminary results of in vitro propagation of Guayule

Science.gov (United States)

Dastoor, M. N.; Schubert, W. W.; Petersen, G. R.

1981-01-01

Guayule, Parthenium argentatum Gray, was first established in tissue culture by Bonner and Arreguin (1950) as a means to study the effects of various chemicals and extracts on rubber production. The propagation of whole guayule plants from tissue culture, however, has not been accomplished. The reported investigation is concerned with such an objective. In an attempt to stimulate rubber production in Guayule, Yokoyama et al. (1977) sprayed juvenile plants with 2-(3,4-dichloro-phenoxy)triethylamine (TEA derivative). This treatment resulted in increased isoprenoid levels in the plant tissue. In the current investigation, experiments were conducted to study the effect of TEA derivative on in vitro cultures. It was found that a suppression of callus formation occurs at a 10 mg/L concentration of TEA derivative with a resultant increase of shoot formation. Lower and higher concentrations of TEA derivative promote callus formation.

Professional burnout in European young oncologists: results of the European Society for Medical Oncology (ESMO) Young Oncologists Committee Burnout Survey.

Science.gov (United States)

Banerjee, S; Califano, R; Corral, J; de Azambuja, E; De Mattos-Arruda, L; Guarneri, V; Hutka, M; Jordan, K; Martinelli, E; Mountzios, G; Ozturk, M A; Petrova, M; Postel-Vinay, S; Preusser, M; Qvortrup, C; Volkov, M N M; Tabernero, J; Olmos, D; Strijbos, M H

2017-07-01

Burnout in health care professionals could have serious negative consequences on quality of patient care, professional satisfaction and personal life. Our aim was to investigate the burnout prevalence, work and lifestyle factors potentially affecting burnout amongst European oncologists ≤40 (YOs). A survey was conducted using the validated Maslach Burnout Inventory (MBI) and additional questions exploring work/lifestyle factors. Statistical analyses were carried out to identify factors associated with burnout. Total of 737 surveys (all ages) were collected from 41 European countries. Countries were divided into six regions. Results from 595 (81%) YOs were included (81% medical oncologists; 52% trainees, 62% women). Seventy-one percent of YOs showed evidence of burnout (burnout subdomains: depersonalization 50%; emotional exhaustion 45; low accomplishment 35%). Twenty-two percent requested support for burnout during training and 74% reported no hospital access to support services. Burnout rates were significantly different across Europe (P women (60% versus 45% P = 0.0001) and low accomplishment was highest in the 26-30 age group (P balance, access to support services, living alone and inadequate vacation time remained independent burnout factors (P balance, access to support services and adequate vacation time may reduce burnout levels. Raising awareness, support and interventional research are needed. © The Author 2017. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Lunabotics Mining Competition: Inspiration through Accomplishment

Science.gov (United States)

Mueller, Robert P.

2012-01-01

Space Mining for resources such as water ice, and regolith, which contain many elements in the form of metals, minerals, volatiles and other compounds, is a necessary step in Space Resource Utilization. One of the primary goals is to extract propellants from the regolith such as oxygen and hydrogen which could then be used for in-space transportation. In addition, the space mining system can be used for various construction tasks that can benefit human and robotic exploration as well as scientific investigations based on the exposed topography. The National Aeronautics & Space Administration (NASA) Lunabotics Mining Competition is a university-level competition designed to engage and retain students in science, technology, engineering and mathematics (STEM). NASA will directly benefit from the competition by encouraging the development of innovative lunar excavation concepts from universities which may result in clever ideas and solutions which could be applied to an actual lunar excavation device or payload. The challenge is for students to design and build a remote controlled or autonomous excavator, called a lunabot, that can collect and deposit a minimum of 10 kilograms of lunar simulant within 15 minutes. The complexities of the challenge include the abrasive characteristics of the lunar simulant, the weight and size limitations of the lunabot, and the ability to control the lunabot from a remote control center or operate autonomously. This paper will present an update of the results and lessons learned during the first and second annual Lunabotics Mining Competitions held in May 2010 and May 2011. It will also preview the 2012 competition with a review of the revised rules. In 2010,22 United States (US) universities competed, and in May 2011 the competition was opened to international participation. In 2011, 36 teams actually competed from 26 USA states and 4 foreign countries (India, Bangladesh, Colombia and Canada). This combined total directly inspired an

The accomplishment of the Engineering Design Activities of IFMIF/EVEDA: The European-Japanese project towards a Li(d,xn) fusion relevant neutron source

Science.gov (United States)

Knaster, J.; Ibarra, A.; Abal, J.; Abou-Sena, A.; Arbeiter, F.; Arranz, F.; Arroyo, J. M.; Bargallo, E.; Beauvais, P.-Y.; Bernardi, D.; Casal, N.; Carmona, J. M.; Chauvin, N.; Comunian, M.; Delferriere, O.; Delgado, A.; Diaz-Arocas, P.; Fischer, U.; Frisoni, M.; Garcia, A.; Garin, P.; Gobin, R.; Gouat, P.; Groeschel, F.; Heidinger, R.; Ida, M.; Kondo, K.; Kikuchi, T.; Kubo, T.; Le Tonqueze, Y.; Leysen, W.; Mas, A.; Massaut, V.; Matsumoto, H.; Micciche, G.; Mittwollen, M.; Mora, J. C.; Mota, F.; Nghiem, P. A. P.; Nitti, F.; Nishiyama, K.; Ogando, F.; O'hira, S.; Oliver, C.; Orsini, F.; Perez, D.; Perez, M.; Pinna, T.; Pisent, A.; Podadera, I.; Porfiri, M.; Pruneri, G.; Queral, V.; Rapisarda, D.; Roman, R.; Shingala, M.; Soldaini, M.; Sugimoto, M.; Theile, J.; Tian, K.; Umeno, H.; Uriot, D.; Wakai, E.; Watanabe, K.; Weber, M.; Yamamoto, M.; Yokomine, T.

2015-08-01

The International Fusion Materials Irradiation Facility (IFMIF), presently in its Engineering Validation and Engineering Design Activities (EVEDA) phase under the frame of the Broader Approach Agreement between Europe and Japan, accomplished in summer 2013, on schedule, its EDA phase with the release of the engineering design report of the IFMIF plant, which is here described. Many improvements of the design from former phases are implemented, particularly a reduction of beam losses and operational costs thanks to the superconducting accelerator concept, the re-location of the quench tank outside the test cell (TC) with a reduction of tritium inventory and a simplification on its replacement in case of failure, the separation of the irradiation modules from the shielding block gaining irradiation flexibility and enhancement of the remote handling equipment reliability and cost reduction, and the water cooling of the liner and biological shielding of the TC, enhancing the efficiency and economy of the related sub-systems. In addition, the maintenance strategy has been modified to allow a shorter yearly stop of the irradiation operations and a more careful management of the irradiated samples. The design of the IFMIF plant is intimately linked with the EVA phase carried out since the entry into force of IFMIF/EVEDA in June 2007. These last activities and their on-going accomplishment have been thoroughly described elsewhere (Knaster J et al [19]), which, combined with the present paper, allows a clear understanding of the maturity of the European-Japanese international efforts. This released IFMIF Intermediate Engineering Design Report (IIEDR), which could be complemented if required concurrently with the outcome of the on-going EVA, will allow decision making on its construction and/or serve as the basis for the definition of the next step, aligned with the evolving needs of our fusion community.

[Contract focused short-term group therapy--results of an evaluation].

Science.gov (United States)

Hirschberg, Rainer; Meyer, Birgit

2010-01-01

A short description outlines the development of commission focused short-term therapy (AFoG) for children and adolescents. Subsequently the generic principles of psychotherapy are applied to AFoG in order to underline the basic assumptions of this variation of systemic group therapy. Behavioural changes arising in different contexts (school, family, group therapy) show the need for an appropriate flexibility of group therapy techniques. The evaluation was accomplished using the Child Behaviour Checklist (CBCL 4-18) at the beginning and 3 month after the end of the group therapy. The results show positive effects which finally are discussed critically.

Treatment with a belly-board device significantly reduces the volume of small bowel irradiated and results in low acute toxicity in adjuvant radiotherapy for gynecologic cancer: results of a prospective study

International Nuclear Information System (INIS)

Martin, Joseph; Fitzpatrick, Kathryn; Horan, Gail; McCloy, Roisin; Buckney, Steve; O'Neill, Louise; Faul, Clare

2005-01-01

Background and purpose: To determine whether treatment prone on a belly-board significantly reduces the volume of small bowel irradiated in women receiving adjuvant radiotherapy for gynecologic cancer, and to prospectively study acute small bowel toxicity using an accepted recording instrument. Material and methods: Thirty-two gynecologic patients underwent simulation with CT scanning supine and prone. Small bowel was delineated on every CT slice, and treatment was prone on the belly-board using 3-5 fields-typically Anterior, Right and Left Lateral, plus or minus Lateral Boosts. Median prescribed dose was 50.4 Gy and all treatments were delivered in 1.8 Gy fractions. Concomitant Cisplatin was administered in 13 patients with cervical carcinoma. Comparison of small bowel dose-volumes was made between supine and prone, with each subject acting as their own matched pair. Acute small bowel toxicity was prospectively measured using the Common Toxicity Criteria: Version 2.0. Results: Treatment prone on the belly-board significantly reduced the volume of small bowel receiving ≥100; ≥95; ≥90; and ≥80% of the prescribed dose, but not ≥50%. This was found whether volume was defined in cubic centimeters or % of total small bowel volume. Of 29 evaluable subjects, 2 (7%) experienced 1 episode each of grade 3 diarrhoea. All other toxicity events were grade 2 or less and comprised diarrhoea (59%), abdominal pain or cramping (48%), nausea (38%), anorexia (17%), vomiting (10%). There were no Grade 4 events and no treatment days were lost due to toxicity. Conclusions: Treatment prone on a belly-board device results in significant small bowel sparing, during adjuvant radiotherapy for gynecologic cancer. The absence of Grade 4 events or Treatment Days Lost compares favorably with the published literature

Results of a WINGDES2/AERO2S Flap Optimization for the TCA

Science.gov (United States)

Yaros, Steven F.

1999-01-01

The codes WINGDES2 and AERO2S were easy to obtain, and technical help was readily available. The codes have a long, well-documented history of successful optimizations of various aircraft configurations. The codes were easy to use, although specification of input data was time-consuming. The Run times were short, allowing the many runs necessary for the Suction Parameter matrix to be accomplished within a day or two. The results of the optimization appear to be reasonable.

Corneal thinning associated with recurrent microbial keratitis resulting from 7-day extended wear of low Dk hydrogel contact lenses: a case report.

Science.gov (United States)

Cardona, Genís; Saona-Santos, Carlos Luís

2010-02-01

Corneal thinning and an increased risk of corneal perforation, resulting from recurrent episodes of microbial keratitis, required a 38-year-old Caucasian female to undergo bilateral corneal grafting. Although strongly advised otherwise, the patient had been a long time user of low oxygen permeability hydrogel contact lenses in a flexible wear regime, with frequent overnight use. Microbial keratitis is a potentially severe contact lens related complication which, if not properly treated, may lead to permanent visual loss. The introduction of silicone-hydrogel materials and daily replacement modalities has not resulted in a significant decrease in the incidence of microbial keratitis, thus suggesting that the condition is mainly dependent on patient hygiene and wearing habits. Non-compliance, which is endemic in contact lens wear, may be combated by increasing patient awareness of the potential risk factors of contact lens misuse. This is accomplished through constant, rigorous information provided by contact lens practitioners.

Editor's choice--Use of disposable radiation-absorbing surgical drapes results in significant dose reduction during EVAR procedures.

Science.gov (United States)

Kloeze, C; Klompenhouwer, E G; Brands, P J M; van Sambeek, M R H M; Cuypers, P W M; Teijink, J A W

2014-03-01

Because of the increasing number of interventional endovascular procedures with fluoroscopy and the corresponding high annual dose for interventionalists, additional dose-protecting measures are desirable. The purpose of this study was to evaluate the effect of disposable radiation-absorbing surgical drapes in reducing scatter radiation exposure for interventionalists and supporting staff during an endovascular aneurysm repair (EVAR) procedure. This was a randomized control trial in which 36 EVAR procedures were randomized between execution with and without disposable radiation-absorbing surgical drapes (Radpad: Worldwide Innovations & Technologies, Inc., Kansas City, US, type 5511A). Dosimetric measurements were performed on the interventionalist (hand and chest) and theatre nurse (chest) with and without the use of the drapes to obtain the dose reduction and effect on the annual dose caused by the drapes. Use of disposable radiation-absorbing surgical drapes resulted in dose reductions of 49%, 55%, and 48%, respectively, measured on the hand and chest of the interventionalist and the chest of the theatre nurse. The use of disposable radiation-absorbing surgical drapes significantly reduces scatter radiation exposure for both the interventionalist and the supporting staff during EVAR procedures. Copyright © 2013 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

Future health care applications resulting from progress in the neurosciences: The significance of neural plasticity research

NARCIS (Netherlands)

Gelijns, A.C.; Graaff, P.J.; Lopes da Silva, F.A.; Gispen, W.H.

1987-01-01

Neurological, communicative and behavioral disorders afflict a significant part of the population in industrialized countries, and these disorders can be expected to gain in importance in the coming decades. In a considerable number of these dis-orders impairments in plasticity, i.e. deficiencies in

Results of efforts by the Convention on Biological Diversity to describe ecologically or biologically significant marine areas.

Science.gov (United States)

Bax, Nicholas J; Cleary, Jesse; Donnelly, Ben; Dunn, Daniel C; Dunstan, Piers K; Fuller, Mike; Halpin, Patrick N

2016-06-01

In 2004, Parties to the Convention on Biological Diversity (CBD) addressed a United Nations (UN) call for area-based planning, including for marine-protected areas that resulted in a global effort to describe ecologically or biologically significant marine areas (EBSAs). We summarized the results, assessed their consistency, and evaluated the process developed by the Secretariat of the CBD to engage countries and experts in 9 regional workshops held from 2011 to 2014. Experts from 92 countries and 79 regional or international bodies participated. They considered 250 million km(2) of the world's ocean area (two-thirds of the total). The 204 areas they examined in detail differed widely in area (from 5.5 km(2) to 11.1 million km(2) ). Despite the initial focus of the CBD process on areas outside national jurisdiction, only 31 of the areas examined were solely outside national jurisdiction. Thirty-five extended into national jurisdictions, 137 were solely within national jurisdictions, and 28 included the jurisdictions of more than 1 country (1 area lacked precise boundaries). Data were sufficient to rank 88-99% of the areas relative to each of the 7 criteria for EBSAs agreed to previously by Parties to the CBD. The naturalness criterion ranked high for a smaller percentage of the EBSAs (31%) than other criteria (51-70%), indicating the difficulty in finding relatively undisturbed areas in the ocean. The highly participatory nature of the workshops, including easy and consistent access to the relevant information facilitated by 2 technical teams, contributed to the workshop participants success in identifying areas that could be ranked relative to most criteria and areas that extend across jurisdictional boundaries. The formal recognition of workshop results by the Conference of Parties to the CBD resulted in these 204 areas being identified as EBSAs by the 196 Parties. They represent the only suite of marine areas recognized by the international community for their

Influence of gender, working field and psychosocial factors on the vulnerability for burnout in mental hospital staff: results of an Austrian cross-sectional study.

Science.gov (United States)

Schadenhofer, Petra; Kundi, Michael; Abrahamian, Heidemarie; Stummer, Harald; Kautzky-Willer, Alexandra

2018-03-01

According to the European Agency for Safety and Health at Work (EU-OSHA), hospitals represent a work environment with high job strain. Prolonged perceived occupational stress may result in symptoms of burnout, such as emotional exhaustion (EE), depersonalisation (DP) and reduced personal accomplishment (PA). Understanding which factors may reduce vulnerability for burnout is an important requirement for well-targeted occupational stress prevention in mental hospital staff. To identify the influence of gender, age, working field, family structure, education, voluntarily occupational training during holidays and length of stay on job on occupational stress perception. In a cross-sectional design, 491 employees (311 female, 180 male) of an Austrian mental health centre participated in the study. The extent of perceived occupational stress was assessed by the Maslach Burnout Inventory (MBI) with the scales for emotional exhaustion, depersonalisation and personal accomplishment. Participants were divided according to their working field in those working with/without patients. Prevalence of emotional exhaustion was higher in women working with patients compared to men working with patients (25% vs. 18%, p = 0.003). Age above 45 years was significantly associated with decreased vulnerability for burnout in men (EE p = 0.040, DP p = 0.010, PA p = 0.007), but not in women. A lower level of education had a significant impact on depersonalisation in both sexes (p = 0.001 for men, p = 0.048 for women). Length of stay on job showed a significant influence on emotional exhaustion. No significant relationship was found between family structure and vulnerability for burnout. Gender had a differential effect on perceived occupational stress indicating a need for gender-tailored preventive strategies. Age, working field, education, voluntarily occupational training during holidays and length of stay on job affect vulnerability for burnout in mental hospital staff. �

Determination of some significant batch culture conditions affecting acetyl-xylan esterase production by Penicillium notatum NRRL-1249

Directory of Open Access Journals (Sweden)

Akhtar MN

2011-05-01

Full Text Available Abstract Background Acetyl-xylan esterase (AXE, EC 3.1.1.72 hydrolyses acetate group from the linear chain of xylopyranose residues bound by β-1,4-linkage. The enzyme finds commercial applications in bio-bleaching of wood pulp, treating animal feed to increase digestibility, processing food to increase clarification and converting lignocellulosics to feedstock and fuel. In the present study, we report on the production of an extracellular AXE from Penicillium notatum NRRL-1249 by solid state fermentation (SSF. Results Wheat bran at a level of 10 g (with 4 cm bed height was optimized as the basal substrate for AXE production. An increase in enzyme activity was observed when 7.5 ml of mineral salt solution (MSS containing 0.1% KH2PO4, 0.05% KCl, 0.05% MgSO4.7H2O, 0.3% NaNO3, 0.001% FeSO4.2H2O and 0.1% (v/w Tween-80 as an initial moisture content was used. Various nitrogen sources including ammonium sulphate, urea, peptone and yeast extract were compared for enzyme production. Maximal enzyme activity of 760 U/g was accomplished which was found to be highly significant (p ≤ 0.05. A noticeable enhancement in enzyme activity was observed when the process parameters including incubation period (48 h, initial pH (5, 0.2% (w/w urea as nitrogen source and 0.5% (v/w Tween-80 as a stimulator were further optimized using a 2-factorial Plackett-Burman design. Conclusion From the results it is clear that an overall improvement of more than 35% in terms of net enzyme activity was achieved compared to previously reported studies. This is perhaps the first report dealing with the use of P. notatum for AXE production under batch culture SSF. The Plackett-Burman model terms were found highly significant (HS, suggesting the potential commercial utility of the culture used (df = 3, LSD = 0.126.

Applied research and development private sector accomplishments

International Nuclear Information System (INIS)

Beskid, N.J.; Devgun, J.S.; Erickson, M.D.; Zielke, M.M.

1992-01-01

This report describes the fiscal year 1990 procurement of contracts with the private sector and the current status of applied research and development conducted for DOE's Office of Technology Development (OTD). This report documents the procurement actions, discusses lessons learned from this activity, and disseminates the results of the procurement to interested parties in DOE and in the private sector

Response to Instruction in Preschool: Results of Two Randomized Studies with Children At Significant Risk of Reading Difficulties

Science.gov (United States)

Lonigan, Christopher J.; Phillips, Beth M.

2015-01-01

Although response-to-instruction (RTI) approaches have received increased attention, few studies have evaluated the potential impacts of RTI approaches with preschool populations. This manuscript presents results of two studies examining impacts of Tier II instruction with preschool children. Participating children were identified as substantially delayed in the acquisition of early literacy skills despite exposure to high-quality, evidence-based classroom instruction. Study 1 included 93 children (M age = 58.2 months; SD = 3.62) attending 12 Title I preschools. Study 2 included 184 children (M age = 58.2 months; SD = 3.38) attending 19 Title I preschools. The majority of children were Black/African American, and about 60% were male. In both studies, eligible children were randomized to receive either 11 weeks of need-aligned, small-group instruction or just Tier I. Tier II instruction in Study 1 included variations of activities for code- and language-focused domains with prior evidence of efficacy in non-RTI contexts. Tier II instruction in Study 2 included instructional activities narrower in scope, more intensive, and delivered to smaller groups of children. Impacts of Tier II instruction in Study 1 were minimal; however, there were significant and moderate-to-large impacts in Study 2. These results identify effective Tier II instruction but indicate that the context in which children are identified may alter the nature of Tier II instruction that is required. Children identified as eligible for Tier II in an RTI framework likely require more intensive and more narrowly focused instruction than do children at general risk of later academic difficulties. PMID:26869730

Development of regulatory guidance on safety reviews of nuclear power plants in Germany. A survey on accomplished and current PSA activities

International Nuclear Information System (INIS)

Berg, H.-P.; Froehmel, T.; Goertz, R.; Rehs, B.

2005-01-01

The paper describes the key points of the accomplished and current regulatory activities in order to revise PSA guide and the corresponding technical documents in Germany. The regulatory German PSA guide covers the fundamental requirements concerning the performance of PSAs in the frame of comprehensive safety reviews. The technical details regarding the performance of PSA are set out in two technical documents (PSA Methods and PSA Data) that have been developed by a working group of PSA experts (FAK PSA). Based on the experiences from the first series of PSRs, international experiences and the fact that PSR is mandatory since April 2002 revisions of all guides are underway. The first guide to be updated is the PSA guide together with the corresponding technical documents. The working programme and the revision process of FAK PSA was finished at the end of 2004 and the technical documents have recently been republished. (author)

Significance evaluation in factor graphs

DEFF Research Database (Denmark)

Madsen, Tobias; Hobolth, Asger; Jensen, Jens Ledet

2017-01-01

in genomics and the multiple-testing issues accompanying them, accurate significance evaluation is of great importance. We here address the problem of evaluating statistical significance of observations from factor graph models. Results Two novel numerical approximations for evaluation of statistical...... significance are presented. First a method using importance sampling. Second a saddlepoint approximation based method. We develop algorithms to efficiently compute the approximations and compare them to naive sampling and the normal approximation. The individual merits of the methods are analysed both from....... Conclusions The applicability of saddlepoint approximation and importance sampling is demonstrated on known models in the factor graph framework. Using the two methods we can substantially improve computational cost without compromising accuracy. This contribution allows analyses of large datasets...

INPP safety upgrade programme. Accomplishments and progress

International Nuclear Information System (INIS)

Vaisnys, P.

1996-01-01

The safety upgrade programme consists of the following parts: Post Chernobyl immediate modifications undertaken to remove obvious deficiencies discovered in the course of analysis of the main causes of Chernobyl accident; Modifications to remove gaps in safety provision discovered as a result of safety assessment investigations; Modifications to remove evident discrepancies in respect to internationally accepted standard. As it follows from above the deep safety investigations were undertaken to put their findings into concrete improvement programme

Areva 2007 results: accelerated growth and significantly improved profitability

International Nuclear Information System (INIS)

2008-02-01

The AREVA group recorded accelerated growth and increased profitability in 2007, meeting both of its objectives for the year. The group made strategic inroads in fast growing markets. AREVA's integrated model met with record success in China, where GGNPC acquired two EPR nuclear islands in a combined order including both the reactors and the fuel, and the creation of a joint venture in engineering. Its T and D division was awarded the largest contract of its history in Qatar, making it the leader in a region where T and D was not even present a few years ago. For more than three years, AREVA has built up its capacity to meet surging demand in the nuclear power and T and D markets through an active policy of research and development and by capitalizing on the diversity and strength of its partnerships. Areva hired 8,600 people in 2006 and 11,500 people in 2007; this represents an investment in recruitment, training and integration of approximately euro 200 million per year. For 2008, the group foresees a further increase in its backlog, sales revenue and operating income. The Areva Group financial statements for 2007 are summarized below: - Backlog: euro 39.8 billion, up 55%; - Sales revenue: euro 11.9 billion, up 9.8% (up 10.4% like-for-like); - Operating income: euro 751 million, i.e. 6.3% operating margin, up 2.6 points compared with 2006; - Net income attributable to equity holders of the parent: euro 743 million (euro 20.95 per share), up from euro 649 million in 2006 (euro 18.31 per share); - Net debt: euro 1.954 billion, linked to the acquisition of UraMin; - Dividend: euro 6.77, to be proposed to the Annual General Meeting of Shareholders convening on April 17, 2008

TEACH Kitchen: A Chronological Review of Accomplishments

Science.gov (United States)

Chae, Jung Hee; Ansa, Benjamin E.; Smith, Selina A.

2017-01-01

Background The Eating and Cooking Healthy (TEACH) Kitchen was founded at the Medical College of Georgia in 2015 as a nutrition-based intervention to combat the high prevalence of obesity and obesity-related chronic diseases in the area of Augusta, Georgia. Despite the importance of diet in the management of chronic diseases, inadequate nutrition education among patients and healthcare providers presents a barrier. The purpose of TEACH Kitchen is to address this gap. Methods TEACH Kitchen is as a student-led initiative that promotes healthy cooking among medical students and patients with chronic diseases. Healthy nutrition and cooking classes are held during the academic year. Participants spend four weeks on each of four modules: obesity, hypertension, hyperlipidemia, and diabetes mellitus. Data collection, which began in January 2017, is currently on going. TEACH Kitchen has collaborated with Augusta University, Sodexo, and Kohl’s. Results Currently, TEACH Kitchen has enrolled 14 patients and 6 children. Anticipated results include measurements of pre-and post-intervention changes in knowledge, attitudes, beliefs, and competence in nutrition, as well as differences in clinical indicators, including body mass index, blood pressure, lipid profile, and HbA1c. Conclusions TEACH Kitchen is the first medical school-based nutrition/cooking education initiative in Augusta, Georgia. It provides patients and medical students with hands-on healthy nutrition/cooking experience with the goal of decreasing the prevalence and improving the outcome of obesity-related diseases. PMID:28890945

Environmentally compliant manufacturing. Project accomplishment summary

International Nuclear Information System (INIS)

Morris, T.O.

1997-01-01

The metal working industry needs to reduce the waste associated with scrap, worn tools, degradation of metal working fluids, and etc. One task in this project concerned metal working fluids (MWF), which typically consists of surfactants, anti-microbial agents, lubricating agents, complexing agents, and a number of other components. The waste stream volume from the MWF can be reduced by judiciously (1) recycling, (2) selective replacement of expended components, and (3) protecting against microbial contamination. This activity consists of developing an analytical method, amenable to automation, which addresses all three of the methods of extending the MWF lifetime, thereby reducing the waste stream. The technology for determining key components in MWF on-line (at the machine tool) did not exist. The Y-12 Plant's collaboration was selected for this particular endeavor because of its ongoing machining operations and expertise in automation. In addition, concerns have been raised regarding chronic exposure of machine shop personnel to metal working fluid mists generated during routine machining operations. The chemical composition of metal working fluids is fairly well known, however, the chemical and physical characteristics of the resulting aerosols (mists) are not as well known. Machinists exposed to these aerosols by inhalation and skin contact sometimes develop unpleasant reactions. The second task involved efforts to characterize mists generated from candidate cutting fluids

Social networking strategies that aim to reduce obesity have achieved significant although modest results.

Science.gov (United States)

Ashrafian, Hutan; Toma, Tania; Harling, Leanne; Kerr, Karen; Athanasiou, Thanos; Darzi, Ara

2014-09-01

The global epidemic of obesity continues to escalate. Obesity accounts for an increasing proportion of the international socioeconomic burden of noncommunicable disease. Online social networking services provide an effective medium through which information may be exchanged between obese and overweight patients and their health care providers, potentially contributing to superior weight-loss outcomes. We performed a systematic review and meta-analysis to assess the role of these services in modifying body mass index (BMI). Our analysis of twelve studies found that interventions using social networking services produced a modest but significant 0.64 percent reduction in BMI from baseline for the 941 people who participated in the studies' interventions. We recommend that social networking services that target obesity should be the subject of further clinical trials. Additionally, we recommend that policy makers adopt reforms that promote the use of anti-obesity social networking services, facilitate multistakeholder partnerships in such services, and create a supportive environment to confront obesity and its associated noncommunicable diseases. Project HOPE—The People-to-People Health Foundation, Inc.

Results From the 2014 National Wilderness Manager Survey

Science.gov (United States)

Ramesh Ghimire; Ken Cordell; Alan Watson; Chad Dawson; Gary T. Green

2015-01-01

A national survey of managers was developed to support interagency wilderness strategic planning. The focus was on major challenges, perceived needs for science and training, and accomplishments of 1995 Strategic Plan objectives. The survey was administered to managers at the four federal agencies with wilderness management responsibilities: the Bureau of Land...

Early Detection of Clinically Significant Prostate Cancer Using Ultrasonic Acoustic Radiation Force Impulse (ARFI) Imaging

Science.gov (United States)

2017-10-01

Toolkit for rapid 3D visualization and image volume interpretation, followed by automated transducer positioning in a user-selected image plane for... Toolkit (IGSTK) to enable rapid 3D visualization and image volume interpretation followed by automated transducer positioning in the user-selected... careers in science, technology, and the humanities. What do you plan to do during the next reporting period to accomplish the goals? If this

Significance of Pharmacogenetics and Pharmacogenomics Research in Current Medical Practice.

Science.gov (United States)

Prakash, Swayam; Agrawal, Suraksha

2016-01-01

Human genome sequencing highlights the involvement of genetic variation towards differential risk of human diseases, presence of different phenotypes, and response to pharmacological elements. This brings the field of personalized medicine to forefront in the era of modern health care. Numerous recent approaches have shown that how variation in the genome at single nucleotide level can be used in pharmacological research. The two broad aspects that deal with pharmacological research are pharmacogenetics and pharmacogenomics. This review encompasses how these variations have created the basis of pharmacogenetics and pharmacogenomics research and important milestones accomplished in these two fields in different diseases. It further discusses at length their importance in disease diagnosis, response of drugs, and various treatment modalities on the basis of genetic determinants.

Integration process and logistics results

International Nuclear Information System (INIS)

2004-01-01

The Procurement and Logistics functions have gone through a process of integration since the beginning of integrated management of Asco and Vandellos II up to the present. These are functions that are likely to be designed for delivering a single product to the rest of the organization, defined from a high level of expectations, and that admit simplifications and materialization of synergy's as they are approached from an integrated perspective. The analyzed functions are as follows: Service and Material Purchasing, Warehouse and Material Management, and Documentation and General Services Management. In all case, to accomplish the integration, objectives, procedures and information systems were unified. As for the organization, a decision was made in each case on whether or not to out source. The decisive corporate strategy to integrate, resulting in actions such as moving corporate headquarters to Vandellos II, corporate consolidation, regulation of employment and implementation of the ENDESA Group Economic Information System (SIE) , has shaped this process, which at present can be considered as practically complete. (Author)

Reusable Solid Rocket Motor - Accomplishments, Lessons, and a Culture of Success

Science.gov (United States)

Moore, Dennis R.; Phelps, Willie J.

2011-01-01

The Reusable Solid Rocket Motor represents the largest solid rocket motor ever flown and the only human rated solid motor. Each Reusable Solid Rocket Motor (RSRM) provides approximately 3-million lb of thrust to lift the integrated Space Shuttle vehicle from the launch pad. The motors burn out approximately 2 minutes later, separate from the vehicle and are recovered and refurbished. The size of the motor and the need for high reliability were challenges. Thrust shaping, via shaping of the propellant grain, was needed to limit structural loads during ascent. The motor design evolved through several block upgrades to increase performance and to increase safety and reliability. A major redesign occurred after STS-51L with the Redesigned Solid Rocket Motor. Significant improvements in the joint sealing systems were added. Design improvements continued throughout the Program via block changes with a number of innovations including development of low temperature o-ring materials and incorporation of a unique carbon fiber rope thermal barrier material. Recovery of the motors and post flight inspection improved understanding of hardware performance, and led to key design improvements. Because of the multidecade program duration material obsolescence was addressed, and requalification of materials and vendors was sometimes needed. Thermal protection systems and ablatives were used to protect the motor cases and nozzle structures. Significant understanding of design and manufacturing features of the ablatives was developed during the program resulting in optimization of design features and processing parameters. The project advanced technology in eliminating ozone-depleting materials in manufacturing processes and the development of an asbestos-free case insulation. Manufacturing processes for the large motor components were unique and safety in the manufacturing environment was a special concern. Transportation and handling approaches were also needed for the large

Development of a cryogenic EOS capability for the Z Pulsed Radiation Source: Goals and accomplishments of FY97 LDRD project

International Nuclear Information System (INIS)

Hanson, D.L.; Johnston, R.R.; Asay, J.R.

1998-03-01

Experimental cryogenic capabilities are essential for the study of ICF high-gain target and weapons effects issues involving dynamic materials response at low temperatures. This report describes progress during the period 2/97-11/97 on the FY97 LDRD project ''Cryogenic EOS Capabilities on Pulsed Radiation Sources (Z Pinch)''. The goal of this project is the development of a general purpose cryogenic target system for precision EOS and shock physics measurements at liquid helium temperatures on the Z accelerator Z-pinch pulsed radiation source. Activity during the FY97 LDRD phase of this project has focused on development of a conceptual design for the cryogenic target system based on consideration of physics, operational, and safety issues, design and fabrication of principal system components, construction and instrumentation of a cryogenic test facility for off-line thermal and optical testing at liquid helium temperatures, initial thermal testing of a cryogenic target assembly, and the design of a cryogenic system interface to the Z pulsed radiation source facility. The authors discuss these accomplishments as well as elements of the project that require further work

Job burnout in 159 anesthesiology trainees

Directory of Open Access Journals (Sweden)

Yesim Cokay Abut

2012-01-01

Full Text Available Background: Anesthesiology may be stressful and most anesthesiologists develop mechanisms for coping. However, inexperienced trainee anesthesiologists seem to be vulnerable. We studied stress perception and job burnout in trainee anesthesiologists. Methods: Responses to perceived stress scale (PSS and Maslach Burnout Inventory (MBI were evaluated in 159 trainee anesthesiologists. Results: In our results, when perceived stress was increased, emotional exhaustion and depersonalization increased but personal accomplishment decreased, as expected. Perceived stress was very high in the early years of training. There was a negative correlation between age and emotional exhaustion and depersonalization, but positive correlation with personal accomplishment. Female anesthesiologists had higher personal accomplishment, but lower depersonalization points than male anesthesiologists in our study. There was no statistical association between marital status, PSS, and MBI; ≥2 children group had a significant high personal accomplishment but low depersonalization and emotional exhaustion scores. Line regression analysis showed a statistically significant relationship between PSS and emotional exhaustion and between age and depersonalization. Conclusions: Social factors such as gender and number of children affect the work life of our trainees.

Median of patient results as a tool for assessment of analytical stability

DEFF Research Database (Denmark)

Jørgensen, Lars Mønster; Hansen, Steen Ingemann; Petersen, Per Hyltoft

2015-01-01

BACKGROUND: In spite of the well-established external quality assessment and proficiency testing surveys of analytical quality performance in laboratory medicine, a simple tool to monitor the long-term analytical stability as a supplement to the internal control procedures is often needed. METHOD......: Patient data from daily internal control schemes was used for monthly appraisal of the analytical stability. This was accomplished by using the monthly medians of patient results to disclose deviations from analytical stability, and by comparing divergences with the quality specifications for allowable...... analytical bias based on biological variation. RESULTS: Seventy five percent of the twenty analytes achieved on two COBASs INTEGRA 800 instruments performed in accordance with the optimum and with the desirable specifications for bias. DISCUSSION: Patient results applied in analytical quality performance...

Significance of Building Maintenance Management Systems towards Sustainable Development

Directory of Open Access Journals (Sweden)

M.A. Othuman Mydin

2014-05-01

Full Text Available Building maintenance management is an organized and effective system of maintenance operations which is set up to deal with problems related to the upkeep of a building. Its goal, aside from locating and remedying a building’s deficiencies, is to effectively minimize the overall costs of maintenance and is also an effort to maximize the gain and benefits from the savings. There are a few factors that influence decisions to undertake maintenance work. The principal goal of maintenance is to protect a building in the early stage of issues as they arise. Some major reasons for maintaining a building include retaining its reputation and value of investments, maintaining the building in a condition which allows it to accomplish its purpose, and presenting a good outer shell. This paper will review and discuss some of the major elements of building maintenance towards achieving sustainable buildings.

Waste Minimization Improvements Achieved Through Six Sigma Analysis Result In Significant Cost Savings

International Nuclear Information System (INIS)

Mousseau, Jeffrey D.; Jansen, John R.; Janke, David H.; Plowman, Catherine M.

2003-01-01

Improved waste minimization practices at the Department of Energy's (DOE) Idaho National Engineering and Environmental Laboratory (INEEL) are leading to a 15% reduction in the generation of hazardous and radioactive waste. Bechtel, BWXT Idaho, LLC (BBWI), the prime management and operations contractor at the INEEL, applied the Six Sigma improvement process to the INEEL Waste Minimization Program to review existing processes and define opportunities for improvement. Our Six Sigma analysis team: composed of an executive champion, process owner, a black belt and yellow belt, and technical and business team members used this statistical based process approach to analyze work processes and produced ten recommendations for improvement. Recommendations ranged from waste generator financial accountability for newly generated waste to enhanced employee recognition programs for waste minimization efforts. These improvements have now been implemented to reduce waste generation rates and are producing positive results

Tacrolimus interaction with nafcillin resulting in significant decreases in tacrolimus concentrations: A case report.

Science.gov (United States)

Wungwattana, Minkey; Savic, Marizela

2017-04-01

Tacrolimus (TAC) is subject to many drug interactions as a result of its metabolism primarily via CYP450 isoenzyme 3A4. Numerous case reports of TAC and CYP3A4 inducers and inhibitors have been described including antimicrobials, calcium channel antagonists, and antiepileptic drugs. We present the case of a 13-year-old patient with cystic fibrosis and a history of liver transplantation, where subtherapeutic TAC concentrations were suspected to be a result of concomitant TAC and nafcillin (NAF) therapy. The observed drug interaction occurred on two separate hospital admissions, during both of which the patient exhibited therapeutic TAC concentrations prior to exposure to NAF, a CYP3A4 inducer. Upon discontinuation of NAF, TAC concentrations recovered in both instances. This case represents a drug-drug interaction between TAC and NAF that has not previously been reported to our knowledge. Despite the lack of existing reports of interaction between these two agents, this case highlights the importance of therapeutic drug monitoring and assessing for any potential drug-drug or drug-food interactions in patients receiving TAC therapy. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

SIMMER Program: its accomplishments

International Nuclear Information System (INIS)

Smith, L.L.; Bell, C.R.; Bohl, W.R.; Luck, L.B.; Wehner, T.R.; DeVault, G.P.; Parker, F.R.

1985-01-01

SIMMER's mechanistic framework has contributed to substantial progress in understanding severe LMFBR accidents, the important accident processes, the process environments, and the need for consistency in assessing the total accident sequence. A comprehensive program of model and code development, experiment analyses, separate-effects studies, and whole-core accident calculations has resolved issues in transition-phase, behavior and showed convincingly that Clinch River Breeder Reactor accident energetics were within design requirements. The current international program continues progress toward improving our understanding of severe accidents in LMFBRs. 17 refs

Collaborative research: Accomplishments & potential

Science.gov (United States)

Katsouyanni, Klea

2008-01-01

Although a substantial part of scientific research is collaborative and increasing globalization will probably lead to its increase, very few studies actually investigate the advantages, disadvantages, experiences and lessons learned from collaboration. In environmental epidemiology interdisciplinary collaboration is essential and the contrasting geographical patterns in exposure and disease make multi-location projects essential. This paper is based on a presentation given at the Annual Conference of the International Society for Environmental Epidemiology, Paris 2006, and is attempting to initiate a discussion on a framework for studying collaborative research. A review of the relevant literature showed that indeed collaborative research is rising, in some countries with impressive rates. However, there are substantial differences between countries in their outlook, need and respect for collaboration. In many situations collaborative publications receive more citations than those based on national authorship. The European Union is the most important host of collaborative research, mainly driven by the European Commission through the Framework Programmes. A critical assessment of the tools and trends of collaborative networks under FP6, showed that there was a need for a critical revision, which led to changes in FP7. In conclusion, it is useful to study the characteristics of collaborative research and set targets for the future. The added value for science and for the researchers involved may be assessed. The motivation for collaboration could be increased in the more developed countries. Particular ways to increase the efficiency and interaction in interdisciplinary and intercultural collaboration may be developed. We can work towards "the principles of collaborative research" in Environmental Epidemiology. PMID:18208596

Mission Accomplishment through Outsourcing

Science.gov (United States)

2006-02-07

salary only and does not include associated benefits. According to the U.S. 7 Chamber of Commerce , employee benefit costs represent 37.6 percent of...articles/ glossary.html#o. 10 Office of Personnel Management, U.S. Government, http://www.opm.gov/oca/06tables/html/dcb.asp. 11 U.S. Chamber of Commerce , http...employee% 20turnover. U.S. Chamber of Commerce . http://www.uschamber.com/press/ releases/2005/january//05-13.htm. USGA. “Employee Turnover

Radiological results for samples collected on paired glass- and cellulose-fiber filters at the Sandia complex, Tonopah Test Range, Nevada

International Nuclear Information System (INIS)

Mizell, Steve A.; Shadel, Craig A.

2016-01-01

Airborne particulates are collected at U.S. Department of Energy sites that exhibit radiological contamination on the soil surface to help assess the potential for wind to transport radionuclides from the contamination sites. Collecting these samples was originally accomplished by drawing air through a cellulose-fiber filter. These filters were replaced with glass-fiber filters in March 2011. Airborne particulates were collected side by side on the two filter materials between May 2013 and May 2014. Comparisons of the sample mass and the radioactivity determinations for the side-by-side samples were undertaken to determine if the change in the filter medium produced significant results. The differences in the results obtained using the two filter types were assessed visually by evaluating the time series and correlation plots and statistically by conducting a nonparametric matched-pair sign test. Generally, the glass-fiber filters collect larger samples of particulates and produce higher radioactivity values for the gross alpha, gross beta, and gamma spectroscopy analyses. However, the correlation between the radioanalytical results for the glass-fiber filters and the cellulose-fiber filters was not strong enough to generate a linear regression function to estimate the glass-fiber filter sample results from the cellulose-fiber filter sample results.

Significant Lactic Acidosis from Albuterol

Directory of Open Access Journals (Sweden)

Deborah Diercks

2018-03-01

Full Text Available Lactic acidosis is a clinical entity that demands rapid assessment and treatment to prevent significant morbidity and mortality. With increased lactate use across many clinical scenarios, lactate values themselves cannot be interpreted apart from their appropriate clinical picture. The significance of Type B lactic acidosis is likely understated in the emergency department (ED. Given the mortality that sepsis confers, a serum lactate is an important screening study. That said, it is with extreme caution that we should interpret and react to the resultant elevated value. We report a patient with a significant lactic acidosis. Though he had a high lactate value, he did not require aggressive resuscitation. A different classification scheme for lactic acidosis that focuses on the bifurcation of the “dangerous” and “not dangerous” causes of lactic acidosis may be of benefit. In addition, this case is demonstrative of the potential overuse of lactates in the ED.

Innovative Integration of Decommissioning and Deactivation Program with Soil-Groundwater Clean Up Program Has Positive Results on Budget and Schedule: A Case Study

International Nuclear Information System (INIS)

Schappell, B; Rucker, G

2007-01-01

An innovative approach to integrate the activities of a decommissioning and deactivation program (D and D) with a soil-groundwater clean up program has had significant positive results saving both money and time at the Department of Energy's Savannah River Site. The accomplishments that have been achieved by the combining the two programs have been remarkable including significant cost savings, economies of scale for sampling and document generation, and alignment of common objectives. Because of the coordination of both activities area-wide ''end states'' can be formulated and be consistent with the customers' cleanup goals and federal regulations. This coordinates and aligns both the environmental clean up and D and D objectives because each must be addressed simultaneously and comprehensively. In this respect, resources from both organizations can be pooled to take advantage of the strengths of each. The new approach allows more efficient use of lean financial resources and optimizes workforce activities to attain the common objectives while being more cost effective, more protective of the environment, and optimizing the use existing resources

The situated accomplishment (aesthetics) of being a cyranoid

DEFF Research Database (Denmark)

Raudaskoski, Pirkko Liisa; Mitchell, Robb

2013-01-01

One aim of participatory innovation is to find new ways of engaging people in various situations that result in ideas and suggestions. For a socio- technical system – whether the design process or its implemented result – to work smoothly (aesthetically) as a specific social order, we should...

Coronary artery disease in a rural population of Bangladesh: is dyslipidemia or adiposity a significant risk?

Directory of Open Access Journals (Sweden)

Sajal Krishna Banerjee

2017-07-01

Full Text Available Background and Aims: The prevalence of cardiovascular diseases (CVD are on the increase worldwide and more in the developing countries. Coronary artery disease (CAD constitutes the major brunt of CVD. Despite the increasing morbidity and mortality, Bangladesh has a few published data on CAD in rural population. This study addressed the prevalence of CAD and its risk factors in rural population of Bangladesh. Study methods: Sixteen villages were purposively selected in a rural area. A population census was conducted in the selected area. The census yielded eligible participants, who reached at least eighteen years of age. Those who willingly consented to participate were enlisted. Each participant was interviewed regarding CAD risk (age, sex, social class, occupation, illness, family history. Anthropometry (height, weight, waist- and hip-girth was recorded. Resting blood pressure (BP was measured. Blood sample was collected for fasting blood glucose (FBG, total cholesterol (Chol, triglycerides (Tg, low density lipoproteins (LDL, very low density lipoproteins (VLDL and high density (HDL. All participants having FBG>5.5mmol/l or systolic (SBP ³135 or diastolic BP (DBP ³85mmHg underwent electrocardiography (ECG. A team of cardiologists selected and accomplished exercise tolerance test (ETT and echocardiography (Echo. Results: The prevalence of CAD was 4.5% (95% CI: 3.85 – 5.15. Compared with the female (3.5%, CI, 2.76 – 4.24 the male participants had significantly higher prevalence of CAD (6.0%, CI, 4.83 – 7.13. Comparison of characteristics between participants with and without CAD showed that age, SBP, DBP and FBG were significantly higher in CAD group. Bivariate analysis showed that age, sex, social class, glycemic status, metabolic syndrome (MetS and smoking were significantly related to CAD. Stepwise logistic regression proved only male sex, rich social class, hypertension and diabetes had independent risk of CAD; whereas, age, obesity

Roll-up of validation results to a target application.

Energy Technology Data Exchange (ETDEWEB)

Hills, Richard Guy

2013-09-01

Suites of experiments are preformed over a validation hierarchy to test computational simulation models for complex applications. Experiments within the hierarchy can be performed at different conditions and configurations than those for an intended application, with each experiment testing only part of the physics relevant for the application. The purpose of the present work is to develop methodology to roll-up validation results to an application, and to assess the impact the validation hierarchy design has on the roll-up results. The roll-up is accomplished through the development of a meta-model that relates validation measurements throughout a hierarchy to the desired response quantities for the target application. The meta-model is developed using the computation simulation models for the experiments and the application. The meta-model approach is applied to a series of example transport problems that represent complete and incomplete coverage of the physics of the target application by the validation experiments.

Results of level 1 PSA in Trillo 1 NPP

International Nuclear Information System (INIS)

Gomez, F.; Lopez, C.

1998-01-01

In July 1991, C. N. Trillo I was requested by the Spanish Regulatory Body (CSN) to perform a PSA that should include: - Level 1 PSA at power - Internal flooding analysis - Level 2 PSA including containment capacity analysis. - External event analyses (fires, external flooding, seismic events and other external events) - Risk analysis for off power conditions (shutdown and low power) - Risk analysis due to other sources of radioactivity In 1992 the Project Plan was issued and the PSA team for the performance of Level 1 PSA was established. Before finishing the Project, it was decided to develop a Phase B to take into account some important modifications that had been accomplished in the Plant and that, probably, could affect the results. Level 1 PSA was finished in March 1998. Both the results of the study and the main conclusions derived from the importance, uncertainty and sensibility analysis performed are presented in this paper. These results de not include the internal flooding analysis conclusions and correspond to PSA revision 0 that is currently being evaluated by the Spanish Regulatory Body. (Author)

Exploration for fossil and nuclear fuels from orbital altitudes. [results of ERTS program for oil exploration

Science.gov (United States)

Short, N. M.

1974-01-01

Results from the ERTS program pertinent to exploration for oil, gas, and uranium are discussed. A review of achievements in relevant geological studies from ERTS, and a survey of accomplishments oriented towards exploration for energy sources are presented along with an evaluation of the prospects and limitations of the space platform approach to fuel exploration, and an examination of continuing programs designed to prove out the use of ERTS and other space system in exploring for fuel resources.

Common genetic variants are significant risk factors for early menopause: results from the Breakthrough Generations Study.

Science.gov (United States)

Murray, Anna; Bennett, Claire E; Perry, John R B; Weedon, Michael N; Jacobs, Patricia A; Morris, Danielle H; Orr, Nicholas; Schoemaker, Minouk J; Jones, Michael; Ashworth, Alan; Swerdlow, Anthony J

2011-01-01

Women become infertile approximately 10 years before menopause, and as more women delay childbirth into their 30s, the number of women who experience infertility is likely to increase. Tests that predict the timing of menopause would allow women to make informed reproductive decisions. Current predictors are only effective just prior to menopause, and there are no long-range indicators. Age at menopause and early menopause (EM) are highly heritable, suggesting a genetic aetiology. Recent genome-wide scans have identified four loci associated with variation in the age of normal menopause (40-60 years). We aimed to determine whether theses loci are also risk factors for EM. We tested the four menopause-associated genetic variants in a cohort of approximately 2000 women with menopause≤45 years from the Breakthrough Generations Study (BGS). All four variants significantly increased the odds of having EM. Comparing the 4.5% of individuals with the lowest number of risk alleles (two or three) with the 3.0% with the highest number (eight risk alleles), the odds ratio was 4.1 (95% CI 2.4-7.1, P=4.0×10(-7)). In combination, the four variants discriminated EM cases with a receiver operator characteristic area under the curve of 0.6. Four common genetic variants identified by genome-wide association studies, had a significant impact on the odds of having EM in an independent cohort from the BGS. The discriminative power is still limited, but as more variants are discovered they may be useful for predicting reproductive lifespan.

Individuals with clinically significant insomnia symptoms are characterised by a negative sleep-related expectancy bias: Results from a cognitive-experimental assessment.

Science.gov (United States)

Courtauld, Hannah; Notebaert, Lies; Milkins, Bronwyn; Kyle, Simon D; Clarke, Patrick J F

2017-08-01

Cognitive models of insomnia consistently suggest that negative expectations regarding the consequences of poor sleep contribute to the maintenance of insomnia. To date, however, no research has sought to determine whether insomnia is indeed characterised by such a negative sleep-related expectancy bias, using objective cognitive assessment tasks which are more immune to response biases than questionnaire assessments. Therefore, the current study employed a reaction-time task assessing biased expectations among a group with clinically significant insomnia symptoms (n = 30) and a low insomnia symptoms group (n = 40). The task involved the presentation of scenarios describing the consequences of poor sleep, and non-sleep related activities, which could be resolved in a benign or a negative manner. The results demonstrated that the high insomnia symptoms group were disproportionately fast to resolve sleep-related scenarios in line with negative outcomes, as compared to benign outcomes, relative to the low insomnia symptoms group. The two groups did not differ in their pattern of resolving non-sleep related scenarios. This pattern of findings is entirely consistent with a sleep-specific expectancy bias operating in individuals with clinically significant insomnia symptoms, and highlights the potential of cognitive-experimental assessment tasks to objectively index patterns of biased cognition in insomnia. Copyright © 2017 Elsevier Ltd. All rights reserved.

Call-to-balloon time dashboard in patients with ST-segment elevation myocardial infarction results in significant improvement in the logistic chain.

Science.gov (United States)

Hermans, Maaike P J; Velders, Matthijs A; Smeekes, Martin; Drexhage, Olivier S; Hautvast, Raymond W M; Ytsma, Timon; Schalij, Martin J; Umans, Victor A W M

2017-08-04

Timely reperfusion with primary percutaneous coronary intervention (pPCI) in ST-segment elevation myocardial infarction (STEMI) patients is associated with superior clinical outcomes. Aiming to reduce ischaemic time, an innovative system for home-to-hospital (H2H) time monitoring was implemented, which enabled real-time evaluation of ischaemic time intervals, regular feedback and improvements in the logistic chain. The objective of this study was to assess the results after implementation of the H2H dashboard for monitoring and evaluation of ischaemic time in STEMI patients. Ischaemic time in STEMI patients transported by emergency medical services (EMS) and treated with pPCI in the Noordwest Ziekenhuis, Alkmaar before (2008-2009; n=495) and after the implementation of the H2H dashboard (2011-2014; n=441) was compared. Median time intervals were significantly shorter in the H2H group (door-to-balloon time 32 [IQR 25-43] vs. 40 [IQR 28-55] minutes, p-value dashboard was independently associated with shorter time delays. Real-time monitoring and feedback on time delay with the H2H dashboard improves the logistic chain in STEMI patients, resulting in shorter ischaemic time intervals.

Production of 3,4-dihydroxy L-phenylalanine by a newly isolated Aspergillus niger and parameter significance analysis by Plackett-Burman design

Directory of Open Access Journals (Sweden)

Haq I

2010-12-01

Full Text Available Abstract Background The amino acid derivative 3,4-dihydroxy L-phenylalanine (L-dopa is gaining interest as a drug of choice for Parkinson's disease. Aspergillus oryzae is commonly used for L-dopa production; however, a slower growth rate and relatively lower tyrosinase activity of mycelia have led to an increasing interest in exploiting alternative fungal cultures. In the present investigation, we report on the microbiological transformation of L-tyrosine to L-dopa accomplished by a newly isolated filamentous fungus Aspergillus niger. Results The culture A. niger (isolate GCBT-8 was propagated in 500 ml Erlenmeyer flasks and the pre-grown mycelia (48 h old were used in the reaction mixture as a source of enzyme tyrosinase. Grinded mycelia gave 1.26 fold higher L-dopa production compared to the intact at 6% glucose (pH 5.5. The rate of L-tyrosine consumption was improved from 0.198 to 0.281 mg/ml. Among the various nitrogen sources, 1.5% peptone, 1% yeast extract and 0.2% ammonium chloride were optimized. The maximal L-dopa was produced (0.365 mg/ml at 0.3% potassium dihydrogen phosphate with L-tyrosine consumption of 0.403 mg/ml. Conclusion Over ~73% yield was achieved (degree of freedom 3 when the process parameters were identified using 2k-Plackett-Burman experimental design. The results are highly significant (p ≤ 0.05 and mark the commercial utility (LSD 0.016 of the mould culture which is perhaps the first ever report on L-dopa production from A. niger.

Avaliação da aeração nasal pré e pós a realização de manobras de massagem e limpeza nasal Evaluation of nasal aeration before and after the accomplishment of massage and nasal cleanness

Directory of Open Access Journals (Sweden)

Fabíola Maria Gomes de Melo

2007-09-01

Full Text Available OBJETIVO: identificar a modificação da aeração nasal após a realização de manobras de massagem e limpeza nasal. MÉTODOS: vinte crianças na faixa etária de quatro a onze anos com diagnóstico de rinite alérgica foram submetidas à avaliação da aeração nasal com o auxílio do espelho milimetrado de Altmann. Inicialmente houve a marcação do ar expirado na placa metálica, posteriormente foram realizadas manobras de massagem e limpeza nasal para retirada da secreção, havendo uma nova marcação para a comparação dos resultados. Foi aplicado o teste Kolmogorov-Smirnov para observar a suposição de normalidade dos dados e o teste t-student para amostras pareadas, sendo todas as conclusões tomadas ao nível de significância de 5%. RESULTADOS: pode-se observar que as médias obtidas da quantificação da aeração nasal após as manipulações e limpeza na região foram significativas pPURPOSE: to identify the modification of nasal aeration after the accomplishment of maneuvers of massage and nasal cleanness. METHODS: twenty children aging from four to eleven years with diagnosis of allergic rhinitis have been submitted to evaluation of nasal aeration with the Altmann's milimetric mirror. Initially, we was marked the air exhaled on the metallic plate, afterwards we made a massage and nasal cleanness for removing of the secretion, having a new benchmark to compare the results. Kolmogorov-Smirnov test was applied to test the assumption of normality for the data and t-student test for paired samples. All conclusions were taken under 5% significance. RESULTS: it was observed that the obtained averages of the nasal aeration after the manipulations and cleanness in the region were significant: p<0,001. CONCLUSION: from the results obtained in this research it was possible to observe a significant increase in the nasal aeration after the massage and nasal cleanness.

Nanomaterials for membrane fouling control: accomplishments and challenges.

Science.gov (United States)

Yang, Qian; Mi, Baoxia

2013-11-01

We report a review of recent research efforts on incorporating nanomaterials-including metal/metal oxide nanoparticles, carbon-based nanomaterials, and polymeric nanomaterials-into/onto membranes to improve membrane antifouling properties in biomedical or potentially medical-related applications. In general, nanomaterials can be incorporated into/onto a membrane by blending them into membrane fabricating materials or by attaching them to membrane surfaces via physical or chemical approaches. Overall, the fascinating, multifaceted properties (eg, high hydrophilicity, superparamagnetic properties, antibacterial properties, amenable functionality, strong hydration capability) of nanomaterials provide numerous novel strategies and unprecedented opportunities to fully mitigate membrane fouling. However, there are still challenges in achieving a broader adoption of nanomaterials in the membrane processes used for biomedical applications. Most of these challenges arise from the concerns over their long-term antifouling performance, hemocompatibility, and toxicity toward humans. Therefore, rigorous investigation is still needed before the adoption of some of these nanomaterials in biomedical applications, especially for those nanomaterials proposed to be used in the human body or in contact with living tissue/body fluids for a long period of time. Nevertheless, it is reasonable to predict that the service lifetime of membrane-based biomedical devices and implants will be prolonged significantly with the adoption of appropriate fouling control strategies. Copyright © 2013 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Variability of the Cyclin-Dependent Kinase 2 Flexibility Without Significant Change in the Initial Conformation of the Protein or Its Environment; a Computational Study.

Science.gov (United States)

Taghizadeh, Mohammad; Goliaei, Bahram; Madadkar-Sobhani, Armin

2016-06-01

Protein flexibility, which has been referred as a dynamic behavior has various roles in proteins' functions. Furthermore, for some developed tools in bioinformatics, such as protein-protein docking software, considering the protein flexibility, causes a higher degree of accuracy. Through undertaking the present work, we have accomplished the quantification plus analysis of the variations in the human Cyclin Dependent Kinase 2 (hCDK2) protein flexibility without affecting a significant change in its initial environment or the protein per se. The main goal of the present research was to calculate variations in the flexibility for each residue of the hCDK2, analysis of their flexibility variations through clustering, and to investigate the functional aspects of the residues with high flexibility variations. Using Gromacs package (version 4.5.4), three independent molecular dynamics (MD) simulations of the hCDK2 protein (PDB ID: 1HCL) was accomplished with no significant changes in their initial environments, structures, or conformations, followed by Root Mean Square Fluctuations (RMSF) calculation of these MD trajectories. The amount of variations in these three curves of RMSF was calculated using two formulas. More than 50% of the variation in the flexibility (the distance between the maximum and the minimum amount of the RMSF) was found at the region of Val-154. As well, there are other major flexibility fluctuations in other residues. These residues were mostly positioned in the vicinity of the functional residues. The subsequent works were done, as followed by clustering all hCDK2 residues into four groups considering the amount of their variability with respect to flexibility and their position in the RMSF curves. This work has introduced a new class of flexibility aspect of the proteins' residues. It could also help designing and engineering proteins, with introducing a new dynamic aspect of hCDK2, and accordingly, for the other similar globular proteins. In

Preliminary results and power analysis of the UAH SEDS G503 GAS can

Science.gov (United States)

Jalbert, Lyle B.; Mustaikis, Steven, II; Nerren, Philip

1995-01-01

The G-503 Get Away Special (GAS) Canister contained four experiments. A stainless steel corrosion experiment, and experiment to mix and cure concrete, a plant root growth chamber, and a group of 8 chambers to characterize diatom growth cycles in microgravity. As would be expected for this selection of experiments a significant amount of power was required to carry out these investigations over several days in a GAS environment. This was accomplished through the use of low power experiment control circuitry, heaters, and an estimate 3.6 kWh battery pack. The battery was designed around 120 standard Duracell Alkaline F cells. This pack weighed 29.5 kg (65 lbs) including a DC/DC converter and the power distribution bus for all of the experiments. Although not rechargeable, this configurations was a fraction of the cost of rechargeable systems and did not require venting to the outside of the can. Combining this with the long term storage performance, 85% of initial capacity after four years at 20 C (70 F), this guarantees sufficient power even with unexpected launch delays. This paper describes the experiments, there operation and initial results. Also, the performance of the power system during the STS-68 SRL2 mission will be addressed.

Getting to know the person behind the illness - the significance of interacting with patients hospitalised in forensic psychiatric settings.

Science.gov (United States)

Salzmann-Erikson, Martin; Rydlo, Cecilia; Wiklund Gustin, Lena

2016-05-01

To describe what nurses want to accomplish in relationships with patients who are hospitalised in forensic psychiatric settings. Relationships between staff and patients in forensic psychiatric settings should be grounded in trust and confidence, and the patients need opportunities for emotional reconciliation. However, relationships can be challenging for nurses, who sometimes distance themselves from patients' expressions of suffering. The role of forensic mental health nurses is nebulous, as are the prescriptives and the implementation of nursing practices. Qualitative descriptive design. In-depth interviews with five nurses who all work in forensic psychiatric settings. We present a descriptive analysis of what nurses want to accomplish in relationships with patients who are hospitalised in forensic psychiatric settings. The results are presented in two main categories: (1) getting to know the person behind the illness and (2) making a difference. Care in forensic psychiatry needs to shift towards a more long-term view of the role of nursing, focusing less on the traditional and stereotypical identity of the productive nurse and more on the care given when nurses slow down and take the time to see the patients as individuals. Establishing trusting relationships with patients in forensic psychiatric settings is viewed as a less oppressive way to control patients and guide them in directions that are preferable for the nurses and for the society. Nurses may use simple strategies in their daily practice such as sitting on the sofa with patients to establish trust. We stress that nurses should abandon policing roles and custodial activities in favour of guiding principles that promote individual recovery, treatment and health-promoting care. © 2016 John Wiley & Sons Ltd.

Significance of Phébus-FP results for plant safety in Switzerland

International Nuclear Information System (INIS)

Birchley, J.; Güntay, S.

2013-01-01

Highlights: • Prototypicality of Phebus is unique for severe accident integral code assessment. • MELCOR and SCDAP show good simulation capability. • Phebus revealed knowledge gaps concerning organic iodine source. • Complementary studies seek to reduce uncertainties. • New engineering technology is developed to resolve organic iodine issue. - Abstract: Switzerland, in common with other countries, uses source term estimates to formulate emergency plans in the unlikely event of an accident with release of activity to the environment. In the past estimates have typically been based on conservative treatments of the accident sequence, necessitated by the limited validation status of models used for the phenomena that control the reactor accident evolution. Although analyses using best-estimate tools frequently indicated substantially smaller releases – knowledge and data were insufficient to place reliance on the methods or the calculated results. The Phébus programme is unique in providing a source of integral transient data on fission product release, transport and chemical behaviour under prototypic conditions, capturing the entire portfolio of processes – transport, material and chemical – and their causal interaction. To this day, no other source of such data is available. These data provide a means to assess, improve and validate methods for source term evaluation and establish the needs for establishing new processes to mitigate the source term. There are strong synergies and complementarities between the Phébus project, the International Source Term Project, the iodine-related studies at PSI and the aerosol retention projects at PSI, and current moves toward improved management/mitigation of severe accidents. The Federal Nuclear Safety Inspectorate (ENSI), Paul Scherrer Institute (PSI) and the Swiss utilities running five nuclear power plants share in the findings. The need to strengthen the foundation on which we perform best

rf impedance of the accelerating beam gap and its significance to the TRIUMF rf system

International Nuclear Information System (INIS)

Poirier, R.

1979-03-01

The rf system at TRIUMF is now operating with the highest Q, the lowest rf leakage into the beam gap, the best voltage stability, and the lowest resonator strongback temperatures ever measured since it was first put into operation. This paper describes the calculation of the rf impedance of the beam gap and its correlation to the rf problems encountered, which eventually led to modifications to the flux guides and resonator tips to accomplish the improved operation of the rf system

Safety analysis results for the control rod banks withdrawal event at a full power of the SMART-P

International Nuclear Information System (INIS)

Yang, S. H.; Chung, Y. J.; Kim, H. C.; Zee, S. Q.

2005-01-01

For the validation of the 330 MWt SMART (System-integrated Modular Advanced ReacTor), a detailed design for the SMART-P has been accomplished by KAERI. In the SMART-P design similar to the SMART design, the soluble boron free design is adapted. This concept results in a larger reactivity worth of the control rod bank compared to that of the commercial pressurized water reactor. Moreover, in the SMART-P design, the control rod banks are fairly well inserted into the core, even at a full power condition. Therefore, accidents related to the reactivity anomalies have been evaluated as crucial events when compared to the other initiating events. In this paper, safety analysis for the control rod banks withdrawal event at a full power of the SMART-P has been accomplished by considering various initial conditions, different withdrawal times of the control rod banks and the reactivity feedback. To perform the safety analysis, the TASS/SMR (Transients And Setpoint Simulation/Small and Medium Reactor) code for a system response and SSF-1 correlation for a CHFR (Critical Heat Flux Ratio) have been used

The somatically significant dose, SSD, and analog of the GSD, the genetically significant dose

International Nuclear Information System (INIS)

Beentjes, L.B.; Duijsings, J.H.

1992-01-01

The medical applications of radiation comprise three main fields namely: Diagnostic Radiology, Radiotherapy and Nuclear Medicine. With the new weighting factors of ICRP (IC91a) the effective dose due to medical applications can be established. I is common to separate the effective dose into the genetic part and the somatic part, SED. In dealing with gonad doses it is important to account for the age of the person at the time of exposure as this will influence the number of children still to be expected from that person. The resulting dose will then be called the genetically significant dose, GSD. In a similar fashion this age factor will be important in considering the chance of tumor induction. The age of patients differs considerably from the average age of the general population. This age difference has to be accounted for if a comparison is to be made with other sources of radiation. This justifies establishing a somatically significant dose, SSD. The reduction of the SED value to a SSD for the medical field due to this phenomenon is .6 for diagnostic radiology, .5 for nuclear medicine and .3 for radiotherapy. Also the extension to more organs at risk, which result in a larger number of weighting factors published by ICRP (IC91a) tends to lower the calculated effective doses. (author)

[Long-term effect of a cognitive intervention on learning and participation in a significant leisure activity in early dementia of Alzheimer type: a case study].

Science.gov (United States)

Provencher, Véronique; Bier, Nathalie; Audet, Thérèse; Gagnon, Lise

2009-06-01

Decreased ability to accomplish significant leisure activities often occurs in early stages of dementia of Alzheimer type (DAT). As a long term effect, it may eventually affect the quality of life of the patient as well as that of the caregiver's. In a previous study, a woman with early DAT (77 years old, MMSE: 24/30) improved her participation in 2 leisure activities (listening to music and praying in a group) following the learning of a few tasks (e.g. using a radio cassette, remembering the significance of an pre-programmed ring) as a result of a cognitive intervention. The present study presents the long term effect of this intervention on the retention of the learned tasks and on spontaneous participation in both leisure activities of her daily living. Measures of tasks' learning and spontaneous participation in activities have been obtained through direct observation (ex: ability to use the tasks learned without assistance) and telephone conversations with the caregiver. The measures were taken 9 to 15 months post-intervention. Nine months after the end of the intervention, the participant could no longer use the radio cassette, but was able to remember the significance of the pre-programmed ring. Similarly, she stopped listening to music, but still attended her prayer group. The intervention appears to maintain participation in a leisure activity for several months in a patient with early DAT, in spite of expected functional decline. This functional impact can be achieved through retention of specific learned tasks as well as by strong external cues (daily pre-programmed ring), and can increase the quality of life for patients with DAT.

MARSite-MARMARA SUPERSITE: Accomplishments and Outlook

Science.gov (United States)

Meral Ozel, Nurcan; Necmioglu, Ocal; Ergintav, Semih; Oguz Ozel, Asım; Italiano, Franco; Favali, Paolo; Bigarre, Pascal; Cakir, Ziyadin; Geli, Louis; Aochi, Hideo; Bossu, Remy; Zulfikar, Can; Sesetyan, Karin

2017-04-01

MARsite Project, funded under FP7-ENV.2012 6.4-2 (Grant 308417) and successfully implemented to Marmara Region during 2014-2016 indicated that focusing on the monitoring of the region and the integration of data from land, sea and space and the processing of this composed data based on sound earth-science research is an effective tool for mitigating damage from future earthquakes. This was achieved by monitoring the earthquake hazard through the ground-shaking and forecast maps, short- and long-term earthquake rate forecasting and time-dependent seismic hazard maps to make important risk-mitigation decisions regarding building design, insurance rates, land-use planning, and public-policy issues that need to balance safety and economic and social interests. MARSite has demonstrated the power of the use of different sensors in the assessment of the earthquake hazard. In addition to the more than 30 scientific publication within the MARsite Project framework, a multidisciplinary innovative borehole seismic observatory and a dilatometer have been installed within MARSite where its a data can be used for a range of seismic studies. Due to the encouraging results obtained from this experiment, it was determined that in the future likely smaller number of stations will be required reducing the cost of national seismic networks. The technical infrastructure of the continuous GPS stations of MAGNET network has been updated within MARSite. Tsunami hazard studies in MARSite in Marmara Sea showed that the tsunami hazard in the Marmara Region is primarily due to submarine landslides triggered by an earthquake and a conceptual Tsunami Early Warning System in the Marmara region strongly coupled with the strong ground motion and existing Earthquake Early Warning System was developed. The existing Earthquake Early Warning and Rapid Response system in the Marmara Region was improved and the installation and test of a pilot seismic landslide monitoring system was taken place in the

Results and Lessons Learned from Performance Testing of Humans in Spacesuits in Simulated Reduced Gravity

Science.gov (United States)

Chappell, Steven P.; Norcross, Jason R.; Gernhardt, Michael L.

2009-01-01

NASA's Constellation Program has plans to return to the Moon within the next 10 years. Although reaching the Moon during the Apollo Program was a remarkable human engineering achievement, fewer than 20 extravehicular activities (EVAs) were performed. Current projections indicate that the next lunar exploration program will require thousands of EVAs, which will require spacesuits that are better optimized for human performance. Limited mobility and dexterity, and the position of the center of gravity (CG) are a few of many features of the Apollo suit that required significant crew compensation to accomplish the objectives. Development of a new EVA suit system will ideally result in performance close to or better than that in shirtsleeves at 1 G, i.e., in "a suit that is a pleasure to work in, one that you would want to go out and explore in on your day off." Unlike the Shuttle program, in which only a fraction of the crew perform EVA, the Constellation program will require that all crewmembers be able to perform EVA. As a result, suits must be built to accommodate and optimize performance for a larger range of crew anthropometry, strength, and endurance. To address these concerns, NASA has begun a series of tests to better understand the factors affecting human performance and how to utilize various lunar gravity simulation environments available for testing.

Impacts of Reinsurance Operations on Significant Items of the Financial Statements of Commercial Insurance Companies According to Czech Accounting Legislation and International Accounting Standards

Directory of Open Access Journals (Sweden)

Jana Gláserová

2015-01-01

Full Text Available The principal aim of the paper is to determine the impact of reinsurance operations in commercial insurance companies, in accordance with the relevant accounting legislation, for certain significant items of the financial statements. In actual fact, the reinsurance operations affect the profit of a commercial insurance company, following the financial statements. The prerequisite for fulfilling the objective of the paper is to analyse the accounting legislation for reinsurance operations in commercial insurance companies. Attention will be devoted also to the method of accounting for reinsurance operations and their specific reporting in various parts of the financial statements of commercial insurance companies. The partial aim of this paper is to identify significant differences in the area of accounting of commercial insurance companies, based on the comparison of accounting practices of the issues examined in accordance with IAS/IFRS. In the conclusion, the authors will address the latest development of necessary steps in adopting the concept of IFRS 4 Phase II and accomplishing the process of the application of IFRS 4 Phase II to the accounts of commercial insurance companies.

[The conflict between work and private life and its relationship with burnout - results of a physician survey in breast cancer centers in North Rhine-Westphalia].

Science.gov (United States)

Nitzsche, A; Driller, E; Kowalski, C; Ansmann, L; Pfaff, H

2013-05-01

This study investigates the conflict between work and private life (work-life conflict and life-work conflict) and its relationship with burnout among physicians in breast cancer centers in North Rhine-Westphalia (n=378). With regard to the construct burnout, we differentiated between the 3 subscales emotional exhaustion, depersonalisation and personal accomplishment of the Maslach burnout inventory. In a structural equation model it was seen that above all the work-life conflict is positively associated with emotional exhaustion whereas the life-work conflict has a stronger positive correlation with depersonalisation and a negative relationship with personal accomplishment. Altogether, the results emphasise the importance of a successful interaction between professional work and private life ("work-life balance") for the health of medical personnel. © Georg Thieme Verlag KG Stuttgart · New York.

What if there were no significance tests?

CERN Document Server

Harlow, Lisa L; Steiger, James H

2013-01-01

This book is the result of a spirited debate stimulated by a recent meeting of the Society of Multivariate Experimental Psychology. Although the viewpoints span a range of perspectives, the overriding theme that emerges states that significance testing may still be useful if supplemented with some or all of the following -- Bayesian logic, caution, confidence intervals, effect sizes and power, other goodness of approximation measures, replication and meta-analysis, sound reasoning, and theory appraisal and corroboration. The book is organized into five general areas. The first presents an overview of significance testing issues that sythesizes the highlights of the remainder of the book. The next discusses the debate in which significance testing should be rejected or retained. The third outlines various methods that may supplement current significance testing procedures. The fourth discusses Bayesian approaches and methods and the use of confidence intervals versus significance tests. The last presents the p...

Encounter Probability of Significant Wave Height

DEFF Research Database (Denmark)

Liu, Z.; Burcharth, H. F.

The determination of the design wave height (often given as the significant wave height) is usually based on statistical analysis of long-term extreme wave height measurement or hindcast. The result of such extreme wave height analysis is often given as the design wave height corresponding to a c...

Estimating the uncertainty of damage costs of pollution: A simple transparent method and typical results

International Nuclear Information System (INIS)

Spadaro, Joseph V.; Rabl, Ari

2008-01-01

Whereas the uncertainty of environmental impacts and damage costs is usually estimated by means of a Monte Carlo calculation, this paper shows that most (and in many cases all) of the uncertainty calculation involves products and/or sums of products and can be accomplished with an analytic solution which is simple and transparent. We present our own assessment of the component uncertainties and calculate the total uncertainty for the impacts and damage costs of the classical air pollutants; results for a Monte Carlo calculation for the dispersion part are also shown. The distribution of the damage costs is approximately lognormal and can be characterized in terms of geometric mean μ g and geometric standard deviation σ g , implying that the confidence interval is multiplicative. We find that for the classical air pollutants σ g is approximately 3 and the 68% confidence interval is [μ g / σ g , μ g σ g ]. Because the lognormal distribution is highly skewed for large σ g , the median is significantly smaller than the mean. We also consider the case where several lognormally distributed damage costs are added, for example to obtain the total damage cost due to all the air pollutants emitted by a power plant, and we find that the relative error of the sum can be significantly smaller than the relative errors of the summands. Even though the distribution for such sums is not exactly lognormal, we present a simple lognormal approximation that is quite adequate for most applications

Summary of the most significant results reported in this session

CERN Document Server

Van De Walle, R T

1980-01-01

In the following a summary is presented of five parallel sessions on light quark had- ron spectroscopy. In general all topics which were discussed in the plenary sessions, and for which the proceedings contain separate (invited) papers, will be left out; only occa- sionally (and for reasons of completeness) will we make a reference to these presentations. Several other restrictions can be made. Nearly all papers submitted to the (parallel) hadron spectroscopy sessions were experimenta1 1 ), the only exceptions being a series of four theoretical papers on the baryonium problem. Furthermore, there was virtually no new information concerning the 'classical' baryons. In particular, no new facts were submitted on the problem of the possible existence of baryon states outside the so-called minimal spectrum, i.e. outside {56,L+ } and {70,L-dd}, the existence of the {ZO}'s, and the exis- even o tence of (baryon) exotic states. There was one contribution on a 'possible' new:".* 2 ), and a report on the final measureme...

Clinical significance of anismus in encopresis.

Science.gov (United States)

Catto-Smith, A G; Nolan, T M; Coffey, C M

1998-09-01

Treatments designed to relieve paradoxical contraction of the anal sphincters during defecation (anismus) have had limited success in children with encopresis. This has raised doubts as to the clinical relevance of this diagnosis in childhood as anorectal dysfunction. Our aim was to determine whether, in patients who had treatment-resistant encopresis, the presence of electromyographic anismus was associated with increased faecal retention. Sixty-eight children with soiling (mean age 8.7+/-2.06 years) were assessed by clinical examination, abdominal radiography and then with anorectal manometry. Patients with electromyographic anismus (n=32; 47%) had significantly increased radiographic rectal faecal retention and were significantly less likely to be able to defecate water-filled balloons. There were no significant differences in response to prior therapy, history of primary encopresis, behavioural adjustment or in sociodemographic data. Our results suggest that electromyographic anismus is associated with obstructed defecation and faecal retention.

Testing Significance Testing

Directory of Open Access Journals (Sweden)

Joachim I. Krueger

2018-04-01

Full Text Available The practice of Significance Testing (ST remains widespread in psychological science despite continual criticism of its flaws and abuses. Using simulation experiments, we address four concerns about ST and for two of these we compare ST’s performance with prominent alternatives. We find the following: First, the 'p' values delivered by ST predict the posterior probability of the tested hypothesis well under many research conditions. Second, low 'p' values support inductive inferences because they are most likely to occur when the tested hypothesis is false. Third, 'p' values track likelihood ratios without raising the uncertainties of relative inference. Fourth, 'p' values predict the replicability of research findings better than confidence intervals do. Given these results, we conclude that 'p' values may be used judiciously as a heuristic tool for inductive inference. Yet, 'p' values cannot bear the full burden of inference. We encourage researchers to be flexible in their selection and use of statistical methods.

Health significance and statistical uncertainty. The value of P-value.

Science.gov (United States)

Consonni, Dario; Bertazzi, Pier Alberto

2017-10-27

The P-value is widely used as a summary statistics of scientific results. Unfortunately, there is a widespread tendency to dichotomize its value in "P0.05" ("statistically not significant"), with the former implying a "positive" result and the latter a "negative" one. To show the unsuitability of such an approach when evaluating the effects of environmental and occupational risk factors. We provide examples of distorted use of P-value and of the negative consequences for science and public health of such a black-and-white vision. The rigid interpretation of P-value as a dichotomy favors the confusion between health relevance and statistical significance, discourages thoughtful thinking, and distorts attention from what really matters, the health significance. A much better way to express and communicate scientific results involves reporting effect estimates (e.g., risks, risks ratios or risk differences) and their confidence intervals (CI), which summarize and convey both health significance and statistical uncertainty. Unfortunately, many researchers do not usually consider the whole interval of CI but only examine if it includes the null-value, therefore degrading this procedure to the same P-value dichotomy (statistical significance or not). In reporting statistical results of scientific research present effects estimates with their confidence intervals and do not qualify the P-value as "significant" or "not significant".

Safety significance evaluation system

International Nuclear Information System (INIS)

Lew, B.S.; Yee, D.; Brewer, W.K.; Quattro, P.J.; Kirby, K.D.

1991-01-01

This paper reports that the Pacific Gas and Electric Company (PG and E), in cooperation with ABZ, Incorporated and Science Applications International Corporation (SAIC), investigated the use of artificial intelligence-based programming techniques to assist utility personnel in regulatory compliance problems. The result of this investigation is that artificial intelligence-based programming techniques can successfully be applied to this problem. To demonstrate this, a general methodology was developed and several prototype systems based on this methodology were developed. The prototypes address U.S. Nuclear Regulatory Commission (NRC) event reportability requirements, technical specification compliance based on plant equipment status, and quality assurance assistance. This collection of prototype modules is named the safety significance evaluation system

Safety significance of ATR passive safety response attributes

International Nuclear Information System (INIS)

Atkinson, S.A.

1990-01-01

The Advanced Test Reactor (ATR) at the Idaho National Engineering Laboratory was designed with some passive safety response attributes which contribute to the safety of the facility. The three passive safety attributes being evaluated in the paper are: 1) In-core and in-vessel natural convection cooling, 2) a passive heat sink capability of the ATR primary coolant system (PCS) for the transfer of decay power from the uninsulated piping to the confinement, and 3) gravity feed of emergency coolant makeup. The safety significance of the ATR passive safety response attributes is that the reactor can passively respond to most transients, given a reactor scram, to provide adequate decay power removal and a significant time for operator action should the normal active heat removal systems and their backup systems both fail. The ATR Interim Level 1 Probabilistic Risk Assessment (PRA) models and results were used to evaluate the significance to ATR fuel damage frequency (or probability) of the above three passive response attributes. The results of the evaluation indicate that the first attribute is a major safety characteristic of the ATR. The second attribute has a noticeable but only minor safety significance. The third attribute has no significant influence on the ATR firewater injection system (emergency coolant system)

Radiographic evaluation of root canal fillings accomplished by undergraduate dental students.

Science.gov (United States)

Yavari, Hamidreza; Samiei, Mohammad; Shahi, Shahriar; Borna, Zahra; Abdollahi, Amir Ardalan; Ghiasvand, Negar; Shariati, Gholamreza

2015-01-01

The purpose of this study was to evaluate the radiographic quality of root canal fillings by fourth-, fifth-, and sixth-year undergraduate students at Tabriz Faculty of Dentistry between 2006 and 2012. A total of 1183 root canal fillings in 620 teeth were evaluated by two investigators (and in case of disagreement by a third investigator) regarding the presence or absence of under-fillings, over-fillings and perforations. For each tooth, preoperative, working and postoperative radiographs were checked. The Pearson's chi-square test was used for statistical evaluation of the data. Inter-examiner agreement was measured by Cohen's kappa (k) values. The level of significance was set at 0.05. Total frequencies of over-filling, under-filling and perforation were 5.6%, 20.4% and 1.9%, respectively. There were significant differences between frequencies of over- and under-fillings (P<0.05). Unacceptable quality, under- and over-fillings were detected in 27.9% of 1183 evaluated canals. The technical quality of root canal therapies performed by undergraduate dental students using step-back preparation and lateral compaction techniques was unacceptable in almost one-fourth of the cases.

Prognostic significance of increased bone marrow microcirculation in newly diagnosed multiple myeloma: results of a prospective DCE-MRI study

Energy Technology Data Exchange (ETDEWEB)

Merz, Maximilian; Hillengass, Jens [Department of Radiology, German Cancer Research Center, Heidelberg (Germany); University of Heidelberg, Department of Hematology, Oncology and Rheumatology, Heidelberg (Germany); Moehler, Thomas M.; Ritsch, Judith; Delorme, Stefan [Department of Radiology, German Cancer Research Center, Heidelberg (Germany); Baeuerle, Tobias [University of Erlangen-Nuremberg, Department of Radiology, Erlangen (Germany); Zechmann, Christian M. [Rinecker Proton Therapy, Muenchen (Germany); Wagner, Barbara; Hose, Dirk [University of Heidelberg, Department of Hematology, Oncology and Rheumatology, Heidelberg (Germany); Jauch, Anna [University of Heidelberg, Institute of Human Genetics, Heidelberg (Germany); Kunz, Christina; Hielscher, Thomas [German Cancer Research Center, Department of Biostatistics, Heidelberg (Germany); Laue, Hendrik [Fraunhofer MEVIS, Bremen (Germany); Goldschmidt, Hartmut [University of Heidelberg, Department of Hematology, Oncology and Rheumatology, Heidelberg (Germany); National Center for Tumor Diseases, Heidelberg (Germany)

2016-05-15

Aim of this prospective study was to investigate prognostic significance of increased bone marrow microcirculation as detected by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for survival and local complications in patients with multiple myeloma (MM). We performed DCE-MRI of the lumbar spine in 131 patients with newly diagnosed MM and analysed data according to the Brix model to acquire amplitude A and exchange rate constant k{sub ep}. In 61 patients a second MRI performed after therapy was evaluated to assess changes in vertebral height and identify vertebral fractures. Correlation analysis revealed significant positive association between beta2-microglobulin as well as immunoparesis with DCE-MRI parameters A and k{sub ep}. Additionally, A was negatively correlated with haemoglobin levels and k{sub ep} was positively correlated with LDH levels. Higher baseline k{sub ep} values were associated with decreased vertebral height in a second MRI (P = 0.007) and A values were associated with new vertebral fractures in the lower lumbar spine (P = 0.03 for L4). Pre-existing lytic bone lesions or remission after therapy had no impact on the occurrence of vertebral fractures. Multivariate analysis revealed that amplitude A is an independent adverse risk factor for overall survival. DCE-MRI is a non-invasive tool with significance for systemic prognosis and vertebral complications. (orig.)

Identification of sequence motifs significantly associated with antisense activity

Directory of Open Access Journals (Sweden)

Peek Andrew S

2007-06-01

Full Text Available Abstract Background Predicting the suppression activity of antisense oligonucleotide sequences is the main goal of the rational design of nucleic acids. To create an effective predictive model, it is important to know what properties of an oligonucleotide sequence associate significantly with antisense activity. Also, for the model to be efficient we must know what properties do not associate significantly and can be omitted from the model. This paper will discuss the results of a randomization procedure to find motifs that associate significantly with either high or low antisense suppression activity, analysis of their properties, as well as the results of support vector machine modelling using these significant motifs as features. Results We discovered 155 motifs that associate significantly with high antisense suppression activity and 202 motifs that associate significantly with low suppression activity. The motifs range in length from 2 to 5 bases, contain several motifs that have been previously discovered as associating highly with antisense activity, and have thermodynamic properties consistent with previous work associating thermodynamic properties of sequences with their antisense activity. Statistical analysis revealed no correlation between a motif's position within an antisense sequence and that sequences antisense activity. Also, many significant motifs existed as subwords of other significant motifs. Support vector regression experiments indicated that the feature set of significant motifs increased correlation compared to all possible motifs as well as several subsets of the significant motifs. Conclusion The thermodynamic properties of the significantly associated motifs support existing data correlating the thermodynamic properties of the antisense oligonucleotide with antisense efficiency, reinforcing our hypothesis that antisense suppression is strongly associated with probe/target thermodynamics, as there are no enzymatic

Design of nuclear emergency decision-making support system based on the results of radiation monitoring

International Nuclear Information System (INIS)

Zheng Qiyan; Zhang Lijun; Huang Weiqi; Chen Lin

2010-01-01

For nuclear emergency decision-making support system based on the results of radiation monitoring, its main assignment is receiving radiation monitoring data and analyzing them, to accomplish some works such as environment influence evaluation, dose assessment for emergency responder, decision-making analyzing and effectiveness evaluation for emergency actions, etc.. This system is made up of server, communication terminal, data-analyzing terminal, GPRS modules, printer, and so on. The whole system make of a LAN. The system's software is made up of six subsystems: data-analyzing subsystem, reporting subsystem, GIS subsystem, communication subsystem, user-managing subsystem and data-base. (authors)

Burnout among young physicians and its association with physicians' wishes to leave: results of a survey in Saxony, Germany.

Science.gov (United States)

Pantenburg, Birte; Luppa, Melanie; König, Hans-Helmut; Riedel-Heller, Steffi G

2016-01-01

Concerns about burnout, and its consequences, among German physicians are rising. However, data on burnout among German physicians are scarce. Also, a suspected association between burnout and German physicians' wishes to leave remains to be studied. Therefore, the extent of burnout, and the association between burnout and wishes to leave clinical practice or to go abroad for clinical work was studied in a sample of young physicians in Saxony. In a cross-sectional survey, all physicians ≤40 years and registered with the State Chamber of Physicians of Saxony, Germany (n = 5956) received a paper-pencil questionnaire inquiring about socio-demographics, job satisfaction, and wishes to leave clinical practice or to go abroad for clinical work. Response rate was 40 % (n = 2357). Burnout was measured with the German version of the Maslach Burnout Inventory - Human Services Survey (MBI) consisting of the subscales emotional exhaustion (feeling emotionally drained), depersonalization (feelings of cynicsm) and personal accomplishment (feelings of personal achievement in job). Variables associated with burnout, and the association between burnout and wishes to leave were assessed in multivariate logistic regression analyses. For emotional exhaustion participants reached a mean of 21.3 [standard deviation = 9.74], for depersonalization a mean of 9.9 [5.92], and for personal accomplishment a mean of 36.3 [6.77]. Men exhibited significantly higher depersonalization than women (11.3 [6.11] versus 9 [5.62], p satisfaction with the components "work environment" and "humaneness", were associated with a lower chance for a high degree of burnout on all subscales. Higher emotional exhaustion and lower personal accomplishment were associated with an increased chance of wishing to leave clinical practice. Higher emotional exhaustion and higher depersonalization were associated with an increased chance of wishing to go abroad for clinical work. Preventing physician

Sibling Competition & Growth Tradeoffs. Biological vs. Statistical Significance.

Science.gov (United States)

Kramer, Karen L; Veile, Amanda; Otárola-Castillo, Erik

2016-01-01

Early childhood growth has many downstream effects on future health and reproduction and is an important measure of offspring quality. While a tradeoff between family size and child growth outcomes is theoretically predicted in high-fertility societies, empirical evidence is mixed. This is often attributed to phenotypic variation in parental condition. However, inconsistent study results may also arise because family size confounds the potentially differential effects that older and younger siblings can have on young children's growth. Additionally, inconsistent results might reflect that the biological significance associated with different growth trajectories is poorly understood. This paper addresses these concerns by tracking children's monthly gains in height and weight from weaning to age five in a high fertility Maya community. We predict that: 1) as an aggregate measure family size will not have a major impact on child growth during the post weaning period; 2) competition from young siblings will negatively impact child growth during the post weaning period; 3) however because of their economic value, older siblings will have a negligible effect on young children's growth. Accounting for parental condition, we use linear mixed models to evaluate the effects that family size, younger and older siblings have on children's growth. Congruent with our expectations, it is younger siblings who have the most detrimental effect on children's growth. While we find statistical evidence of a quantity/quality tradeoff effect, the biological significance of these results is negligible in early childhood. Our findings help to resolve why quantity/quality studies have had inconsistent results by showing that sibling competition varies with sibling age composition, not just family size, and that biological significance is distinct from statistical significance.

Sibling Competition & Growth Tradeoffs. Biological vs. Statistical Significance.

Directory of Open Access Journals (Sweden)

Karen L Kramer

Full Text Available Early childhood growth has many downstream effects on future health and reproduction and is an important measure of offspring quality. While a tradeoff between family size and child growth outcomes is theoretically predicted in high-fertility societies, empirical evidence is mixed. This is often attributed to phenotypic variation in parental condition. However, inconsistent study results may also arise because family size confounds the potentially differential effects that older and younger siblings can have on young children's growth. Additionally, inconsistent results might reflect that the biological significance associated with different growth trajectories is poorly understood. This paper addresses these concerns by tracking children's monthly gains in height and weight from weaning to age five in a high fertility Maya community. We predict that: 1 as an aggregate measure family size will not have a major impact on child growth during the post weaning period; 2 competition from young siblings will negatively impact child growth during the post weaning period; 3 however because of their economic value, older siblings will have a negligible effect on young children's growth. Accounting for parental condition, we use linear mixed models to evaluate the effects that family size, younger and older siblings have on children's growth. Congruent with our expectations, it is younger siblings who have the most detrimental effect on children's growth. While we find statistical evidence of a quantity/quality tradeoff effect, the biological significance of these results is negligible in early childhood. Our findings help to resolve why quantity/quality studies have had inconsistent results by showing that sibling competition varies with sibling age composition, not just family size, and that biological significance is distinct from statistical significance.

Personal Establishment and Accomplishment of Public Service Values

Directory of Open Access Journals (Sweden)

Mirko PEČARIČ

2013-02-01

Full Text Available Public objectives are mostly developed within public administrations, which despite apparent Weberian rationality work mainly evolutionarily, i.e. by imitation of what already works in other areas and what randomly brings good results. The rule of law that is fundamental to the Western democratic order cannot work without morality and legal values. If we want workable values, we must understand them at their core, which is not the domain of law. The starting point is an individual who operates primarily on the basis of his personal characteristics regardless of all the present theories of the public administration. Entering into the unknown with full preparedness for the changes will be the motto of the future public administration. We are much closer to such a stance if we know how the public service values are really established and implemented.

A Limited Structural Modification Results in a Significantly More Efficacious Diazachrysene-Based Filovirus Inhibitor

Directory of Open Access Journals (Sweden)

Rekha G. Panchal

2012-08-01

Full Text Available Ebola (EBOV and Marburg (MARV filoviruses are highly infectious pathogens causing deadly hemorrhagic fever in humans and non-human primates. Promising vaccine candidates providing immunity against filoviruses have been reported. However, the sporadic nature and swift progression of filovirus disease underlines the need for the development of small molecule therapeutics providing immediate antiviral effects. Herein we describe a brief structural exploration of two previously reported diazachrysene (DAAC-based EBOV inhibitors. Specifically, three analogs were prepared to examine how slight substituent modifications would affect inhibitory efficacy and inhibitor-mediated toxicity during not only EBOV, but also MARV cellular infection. Of the three analogs, one was highly efficacious, providing IC₅₀ values of 0.696 µM ± 0.13 µM and 2.76 µM ± 0.21 µM against EBOV and MARV infection, respectively, with little or no associated cellular toxicity. Overall, the structure-activity and structure-toxicity results from this study provide a framework for the future development of DAAC-based filovirus inhibitors that will be both active and non-toxic in vivo.

Sodium leak and combustion experiment-II report. Evaluation result of damage of mild steel liner

Energy Technology Data Exchange (ETDEWEB)

Aoto, K.; Hirakawa, Y.; Kuroda, T. [Power Reactor and Nuclear Fuel Development Corp., Oarai, Ibaraki (Japan). Oarai Engineering Center

1996-09-01

Several material analyses on damage of the floor liner made of a mild steel which was in the test cell of the second sodium leak and combustion experiment (Test-2) performed in OEC/PNC on June 7 in 1996 were carried out to clarify the following issues. (1) Difference of the corrosion mechanism of Test-2 liner to that of the first sodium leak and combustion experiment (Test-1) liner. (2) The vital factor which can desides corrosion mechanism and damage location. The following analyses were accomplished. (1) Microstructure observation, (2) EPMA for cross-section of vicinity of corroded area, (3) X-ray diffraction (XRD) for the interface between corrosion product-liner (mild steel). The differences between the corrosion mechanism of Test-1 liner which is seemed to be the same that of `MONJU` liner and that of Test-2 liner is discussed based on the results of these material analyses. As the result, the Na-Fe double oxidization with mechanical/chemical removal of reaction product can be occurred on the Test-1 and `MONJU` liner. On the other hand, a hot-corrosion, that is the molten salt type corrosion is subject to be thinning of the Test-2 liner. All failures of Test-2 liner surround at the halfway up a convex. Considering the above corrosion mechanism, that fact leads that significant damage is occurred at the molten salt level. (author)

Getting to know the person behind the illness - the significance of interacting with patients hospitalised in forensic psychiatric settings

OpenAIRE

Salzmann-Erikson, Martin; Rydlo, Cecilia; Wiklund Gustin, Lena

2016-01-01

Source: http://onlinelibrary.wiley.com/doi/10.1111/jocn.13252/epdf AIMS AND OBJECTIVES: To describe what nurses want to accomplish in relationships with patients who are hospitalised in forensic psychiatric settings. BACKGROUND: Relationships between staff and patients in forensic psychiatric settings should be grounded in trust and confidence, and the patients need opportunities for emotional reconciliation. However, relationships can be challenging for nurses, who sometimes dist...

Medico-economic evaluation of healthcare products. Methodology for defining a significant impact on French health insurance costs and selection of benchmarks for interpreting results.

Science.gov (United States)

Dervaux, Benoît; Baseilhac, Eric; Fagon, Jean-Yves; Biot, Claire; Blachier, Corinne; Braun, Eric; Debroucker, Frédérique; Detournay, Bruno; Ferretti, Carine; Granger, Muriel; Jouan-Flahault, Chrystel; Lussier, Marie-Dominique; Meyer, Arlette; Muller, Sophie; Pigeon, Martine; De Sahb, Rima; Sannié, Thomas; Sapède, Claudine; Vray, Muriel

2014-01-01

Decree No. 2012-1116 of 2 October 2012 on medico-economic assignments of the French National Authority for Health (Haute autorité de santé, HAS) significantly alters the conditions for accessing the health products market in France. This paper presents a theoretical framework for interpreting the results of the economic evaluation of health technologies and summarises the facts available in France for developing benchmarks that will be used to interpret incremental cost-effectiveness ratios. This literature review shows that it is difficult to determine a threshold value but it is also difficult to interpret then incremental cost effectiveness ratio (ICER) results without a threshold value. In this context, round table participants favour a pragmatic approach based on "benchmarks" as opposed to a threshold value, based on an interpretative and normative perspective, i.e. benchmarks that can change over time based on feedback. © 2014 Société Française de Pharmacologie et de Thérapeutique.

Statistical significance of cis-regulatory modules

Directory of Open Access Journals (Sweden)

Smith Andrew D

2007-01-01

Full Text Available Abstract Background It is becoming increasingly important for researchers to be able to scan through large genomic regions for transcription factor binding sites or clusters of binding sites forming cis-regulatory modules. Correspondingly, there has been a push to develop algorithms for the rapid detection and assessment of cis-regulatory modules. While various algorithms for this purpose have been introduced, most are not well suited for rapid, genome scale scanning. Results We introduce methods designed for the detection and statistical evaluation of cis-regulatory modules, modeled as either clusters of individual binding sites or as combinations of sites with constrained organization. In order to determine the statistical significance of module sites, we first need a method to determine the statistical significance of single transcription factor binding site matches. We introduce a straightforward method of estimating the statistical significance of single site matches using a database of known promoters to produce data structures that can be used to estimate p-values for binding site matches. We next introduce a technique to calculate the statistical significance of the arrangement of binding sites within a module using a max-gap model. If the module scanned for has defined organizational parameters, the probability of the module is corrected to account for organizational constraints. The statistical significance of single site matches and the architecture of sites within the module can be combined to provide an overall estimation of statistical significance of cis-regulatory module sites. Conclusion The methods introduced in this paper allow for the detection and statistical evaluation of single transcription factor binding sites and cis-regulatory modules. The features described are implemented in the Search Tool for Occurrences of Regulatory Motifs (STORM and MODSTORM software.

Results of the PEP`93 intercomparison of reference cell calibrations and newer technology performance measurements

Energy Technology Data Exchange (ETDEWEB)

Osterwald, C.R.; Emery, K. [National Renewable Energy Lab., Golden, CO (United States); Anevsky, S. [All-Union Research Inst. for Optophysical Measurements, Moscow (Russian Federation)] [and others

1996-05-01

This paper presents the results of an international intercomparison of photovoltaic (PV) performance measurements and calibrations. The intercomparison, which was organized and operated by a group of experts representing national laboratories from across the globe (i.e., the authors of this paper), was accomplished by circulating two sample sets. One set consisted of twenty silicon reference cells that would, hopefully, form the basis of an international PV reference scale. A qualification procedure applied to the calibration results gave average calibration numbers with an overall standard deviation of less than 2% for the entire set. The second set was assembled from a wide range of newer technologies that present unique problems for PV measurements. As might be expected, these results showed much larger differences among laboratories. Methods were then identified that should be used to measure such devices, along with problems to avoid.

Surgical results in patients with unruptured asymptomatic cerebral aneurysms. Significance of evaluation of neuropsychological function, magnetic resonance images and cerebral blood flow

International Nuclear Information System (INIS)

Kumon, Yoshiaki; Watanabe, Hideaki; Igase, Keiji; Nagato, Shigeyuki; Fukumoto, Shinya; Iwata, Shinji; Ohue, Shiro; Ohnishi, Takanori

2006-01-01

We evaluated neuropsychological function, magnetic resonance (MR) images and cerebral blood flow (CBF) in patients with unruptured asymptomatic cerebral aneurysms. Among consecutive operations (n=73) on 70 patients since 2000, direct surgery was performed in 53 operations on 50 patients, and intravascular surgery was performed in 20 operations on 20 patients. Surgical results of direct surgery were studied. Direct surgery was selected mainly for patients with small and anterior circulation aneurysms. MR imaging was conducted 1 week after surgery, and Wechsler Adult Intelligence Scale-Revised (WAIS-R) examination and CBF measurement using 133 Xe-SPECT were done before and 1 month after surgery. Abnormal neurological findings were recognized postoperatively in 26% of surgeries. Among them, visual disturbance was permanent in 4% of surgeries, all of which were surgeries for paraclinoid internal carotid artery aneurysms. WAIS-R results deteriorated in 26% of surgeries at 1 month and at least in 5% of surgeries at 1 year after surgery. MR images at 1 week after surgery revealed brain damage in 30% of surgeries and subdural fluid collection in 19% of surgeries. Patients with large brain damage or thick subdural fluid collection frequently showed neurological deficits and/or WAISR deterioration. These complications were recognized frequently in patients with ACoA aneurysms. Resting CBF decreased significantly in the area supplied by the anterior cerebral artery and anterior border zone on the operated side postoperatively. The brain damage and subdural fluid collection were observed frequently and caused neurological deficits and neuropsychological dysfunction, although these were usually transient. It may be necessary to evaluate neuropsychological function, MRI and CBF in patients with unruptured asymptomatic cerebral aneurysms to improve surgical results. (author)

Past Accomplishments and Future Challenges

Science.gov (United States)

Danielson, Louis; Doolittle, Jennifer; Bradley, Renee

2005-01-01

Three broad issues continue to dramatically impact the education of children with specific learning disabilities (SLD): (1) the development and implementation of scientifically defensible methods of identification; (2) the development and implementation of scientific interventions to ensure that children with SLD have access to and make progress…

The Measurement of Instructional Accomplishments.

Science.gov (United States)

Fraley, Lawrence E.; Vargas, Ernest A.

Instructional System Technology in recent years has been characterized by an increase in individualized instruction and the modularization of the curriculum. In traditional systems the learners are forced to take blocks of instruction the size of entire courses and these are much too large. The courses can now be broken down into conceptual…

Nuclear power-accomplishments and prospects

International Nuclear Information System (INIS)

Anon.

1989-01-01

Nuclear energy is probably unique in being an international endeavor. The US was correct in 1973 in embracing nuclear energy, and is correct even today in continuing to champion and push this technology. Several major events justify this view. They include: the world's growing dependence on oil and America's increasing dependence on the unstable Middle East; steady high growth in electricity demand; culminated in this summer's record peak demands across the country, and while it was a hot summer, most of that increased demand was industrial activity-economic activity-not due to heat and renewed emphasis on the environment. The job of nuclear utilities and manufacturers is to work with continuity towards greater reliability, safety, and economy of our plants as they exist today. Nuclear power offers clear objective advantages if one is able to look beyond the illusions of the immediate situation. Taipower believes that nuclear power should be the major energy resource for Taiwan in the future. The first problem facing Taipower is the long lead time required for project approval. The second problem Taipower faces is the difficulty in obtaining a public consensus. Three main rational and irrational reasons are decisive for this future development of nuclear energy in Germany: energy structure, economics, and public acceptance. The use of nuclear energy is ethically not irresponsible, but it is ethically irresponsible not to use nuclear energy. A lot of modifications on the European plants have taken place to try to minimize the chance of having an accident and, in case it should happen, to limit the consequences. Another problem is waste deposits. As long as there is no answer to this question, the public will continue to debate on this issue

Technical Report --Final Work Accomplishment

Energy Technology Data Exchange (ETDEWEB)

Kim, Eun Heui

2007-11-19

The main goal of this project was to understand the solution structure of nonlinear boundary value problems arising in self-similar solutions of nonlinear systems of multidimensional conservation laws. This project further extended to study on biocomplex systems including Morphogen gradients systems (reaction-diffusion systems) and tumor growth and its treatment model problems (free boundary, conservation of mass and reaction-diffusion systems). The list of publications and the summary of those publications are listed.

Differences in the perception of characteristics of excellence of clinical tutors among residents and consultants at an emergency medicine residency program a qualitative research

Directory of Open Access Journals (Sweden)

Muna Saleem Aljahany

2013-01-01

Full Text Available Introduction: Defining exactly what characterizes a clinical tutor as excellent and another less effective, is an important task in assessing the effectiveness of clinical training and guiding faculty development. Aim: We aimed to evaluate those characteristics and measure differences in their perception among accomplished and non-accomplished consultants and residents in the Emergency Department. We also compared perceptions between the different groups of participants. Methods: The characteristics measured were extracted from an extensive search of previously published studies summarized in a review article. A qualitative study was conducted, using a 20 item questionnaire piloted from the refined characteristics (good indicator of reliability; Cronbach′s Alpha = 0.86. The questionnaire was distributed among all consultants and residents in Saudi Board of Emergency Medicine. Results: No significant difference between consultants′ and residents′ perception was found. "Sincere" was an exception 87.8% versus 55.1%, P = 0.013. Consultants′ specifications did not seem to affect perception on overall scores and its component sub-scores. Conclusion: Since results showed no relation between accomplished and non-accomplished consultants in perceiving those qualities, we excluded the lack of knowledge of those characteristics as a cause of being accomplished or non-accomplished. We suggest a greater dedication from program developers towards creating more opportunities to involve more consultants in basic Emergency Medicine training.

Significance analysis of lexical bias in microarray data

Directory of Open Access Journals (Sweden)

Falkow Stanley

2003-04-01

Full Text Available Abstract Background Genes that are determined to be significantly differentially regulated in microarray analyses often appear to have functional commonalities, such as being components of the same biochemical pathway. This results in certain words being under- or overrepresented in the list of genes. Distinguishing between biologically meaningful trends and artifacts of annotation and analysis procedures is of the utmost importance, as only true biological trends are of interest for further experimentation. A number of sophisticated methods for identification of significant lexical trends are currently available, but these methods are generally too cumbersome for practical use by most microarray users. Results We have developed a tool, LACK, for calculating the statistical significance of apparent lexical bias in microarray datasets. The frequency of a user-specified list of search terms in a list of genes which are differentially regulated is assessed for statistical significance by comparison to randomly generated datasets. The simplicity of the input files and user interface targets the average microarray user who wishes to have a statistical measure of apparent lexical trends in analyzed datasets without the need for bioinformatics skills. The software is available as Perl source or a Windows executable. Conclusion We have used LACK in our laboratory to generate biological hypotheses based on our microarray data. We demonstrate the program's utility using an example in which we confirm significant upregulation of SPI-2 pathogenicity island of Salmonella enterica serovar Typhimurium by the cation chelator dipyridyl.

he Impact of Burnout Level of Employees on Intention to L eave: A Research on the Hotels in Hatay

Directory of Open Access Journals (Sweden)

Zeynep Aslan

2015-09-01

Full Text Available The purpose of this study is to determine the impact of burnout level of employees on intention to leavein three, four, five-star and boutique hotels in Hatay. The scales developed previously were used to measure the independent variable; emotional exhaustion, personal accomplishment, depersonalization and the dependent variable; intentiontoleave. In this study, judgmental sampling method was used and the employees in three, four, five star and boutique hotels in Hatay were included in the field research. The result of this studying dedicated that employees had lower levels of burnout. The results also showed that sub-dimensions of burnout, emotional exhaustion, depersonalization and personal accomplishment significantly associated with intentionto leave. The results also showed that intention to leave increased when emotional exhaustion and depersonalization increased, but reduced when personal accomplishment increased. Consequently, this study pointed out that the burnout level of employees had an effect on intention to leave

The International Space Station Research Opportunities and Accomplishments

Science.gov (United States)

Alleyne, Camille W.

2011-01-01

In 2010, the International Space Station (ISS) construction and assembly was completed to become a world-class scientific research laboratory. We are now in the era of utilization of this unique platform that facilitates ground-breaking research in the microgravity environment. There are opportunities for NASA-funded research; research funded under the auspice of the United States National Laboratory; and research funded by the International Partners - Japan, Europe, Russia and Canada. The ISS facilities offer an opportunity to conduct research in a multitude of disciplines such as biology and biotechnology, physical science, human research, technology demonstration and development; and earth and space science. The ISS is also a unique resource for educational activities that serve to motivate and inspire students to pursue careers in Science, Technology, Engineering and Mathematics. Even though we have just commenced full utilization of the ISS as a science laboratory, early investigations are yielding major results that are leading to such things as vaccine development, improved cancer drug delivery methods and treatment for debilitating diseases, such as Duchenne's Muscular Dystrophy. This paper

Real significance of skin contamination is

International Nuclear Information System (INIS)

Sudmann, R.H.

1983-01-01

For five decades, health physicists have discussed the thickness, area, significance of radioactive contamination and the exposures to various portions of the skin. Concern about instances of skin contamination extend beyond the resultant organ dose simply because it is a recognizable and quantifiable event. As such, there is a tendency for management and regulatory agencies to use it as a trend indicator. The final result is a score card similar to the list of OSHA reportable accidents. In fact, the skin contamination incidence rate has a somewhat different meaning to the health physicist, to the manager, and to the regulator. The question must then be asked, What is the true significance of skin contamination, Is it the resultant skin dose, Is it an indicator of loss of control, Is it both or neither. In order to answer these questions, Rockwell Hanford Operations began analysis of the previous five years records of skin contamination cases. Since by policy each incidence of skin contamination is documented, a large percentage of the 425 records analyzed were of low level activity (less than 100 dpm/cm 2 ) on the extremeties, primarily hands and fingers. Most of these cases were readily decontaminated with soap and water. Individual elements studied included: detection/monitoring methods and limits; impact of type of operation on the incidence rate; causes of and methods for reduction of the incidence rate; reporting and documentation; and dose assessment. Results of the study indicate that skin contamination rarely presents a beta dose problem because it is normally highly localized on the extremeties. Only in unusual cases does it represent a potential for internal deposition. Thus, the real importance of skin contamination incidence is as an indicator of deteriorating conditions and should be reviewed by health physicists, managers and regulators as such

Detecting Novelty and Significance

Science.gov (United States)

Ferrari, Vera; Bradley, Margaret M.; Codispoti, Maurizio; Lang, Peter J.

2013-01-01

Studies of cognition often use an “oddball” paradigm to study effects of stimulus novelty and significance on information processing. However, an oddball tends to be perceptually more novel than the standard, repeated stimulus as well as more relevant to the ongoing task, making it difficult to disentangle effects due to perceptual novelty and stimulus significance. In the current study, effects of perceptual novelty and significance on ERPs were assessed in a passive viewing context by presenting repeated and novel pictures (natural scenes) that either signaled significant information regarding the current context or not. A fronto-central N2 component was primarily affected by perceptual novelty, whereas a centro-parietal P3 component was modulated by both stimulus significance and novelty. The data support an interpretation that the N2 reflects perceptual fluency and is attenuated when a current stimulus matches an active memory representation and that the amplitude of the P3 reflects stimulus meaning and significance. PMID:19400680

Significant Variation of Post-critical SsPmp Amplitude as a Result of Variation in Near-surface Velocity: Observations from the Yellowknife Array

Science.gov (United States)

Ferragut, G.; Liu, T.; Klemperer, S. L.

2017-12-01

In recent years Virtual Deep Seismic Sounding (VDSS) emerged as a novel method to image the Moho, which uses the post-critical reflection P waves at the Moho generated by teleseismic S waves at the free surface near the receivers (SsPmp). However, observed SsPmp sometimes have significantly lower amplitude than predicted, raising doubts among the seismic community on the theoretical basis of the method. With over two decades of continuous digital broadband records and major subduction zones in the range of 30-50 degrees, the Yellowknife Array in northern Canada provides a rich opportunity for observation of post-critical SsPmp. We analyze S wave coda of events with epicenter distances of 30-50°, and pay special attention to earthquakes in a narrow azimuth range that ­­­encompasses the Kamchatka Peninsula. Among 21 events with strong direct S energy on the radial components, we observe significant variation of SsPmp energy. After associating the SsPmp energy with the virtual source location of each event, we observe a general trend of decreasing SsPmp energy from NE to SW. As the trend coincides with the transition from exposed basement of the Slave Craton to Paleozoic platform covered by Phanerozoic sediment, we interpret the decreasing SsPmp energy as a result of lower S velocity at the virtual sources, which reduces S-to-P reflection coefficients. We plan to include more events from the Aleutian Islands, the virtual sources of which are primarily located in the Paleozoic platform. This will allow us to further investigate the relationship between SsPmp amplitude and near-surface velocity.

Gas revenue increasingly significant

International Nuclear Information System (INIS)

Megill, R.E.

1991-01-01

This paper briefly describes the wellhead prices of natural gas compared to crude oil over the past 70 years. Although natural gas prices have never reached price parity with crude oil, the relative value of a gas BTU has been increasing. It is one of the reasons that the total amount of money coming from natural gas wells is becoming more significant. From 1920 to 1955 the revenue at the wellhead for natural gas was only about 10% of the money received by producers. Most of the money needed for exploration, development, and production came from crude oil. At present, however, over 40% of the money from the upstream portion of the petroleum industry is from natural gas. As a result, in a few short years natural gas may become 50% of the money revenues generated from wellhead production facilities

Significance of atypical squamous cells of undetermined significance on ThinPrep papanicolaou smears.

Science.gov (United States)

Eltabbakh, G H; Lipman, J N; Mount, S L; Morgan, A

2000-10-01

The aim of this study was to assess the prevalence and risk factors predictive of dysplasia among women seen in a gynecologic oncology service with the cytologic diagnosis of atypical squamous cells of undetermined significance (ASCUS) on Papanicolaou smears obtained by the ThinPrep method. Patients with ASCUS ThinPrep Papanicolaou smears seen at the Division of Gynecologic Oncology, University of Vermont, between 1997 and 1999 were identified. The cytologic smears were reviewed and subtyped into reactive or suggestive of squamous intraepithelial lesion (SIL). The charts of these patients were reviewed and the following information was abstracted: age, gravidity, parity, menopausal status, use of hormonal replacement therapy, smoking, history of pelvic cancer, history of radiation therapy, history of abnormal Papanicolaou smear and its treatment, history of human papillomavirus (HPV) infection, and follow-up information including results of repeat Papanicolaou smears, colposcopy, and biopsies. The prevalence of dysplasia was calculated. The demographic features of women with ASCUS, reactive, were compared with those with ASCUS, SIL, using a two-sample t test, chi(2), and Fisher's exact test. Risk factors predictive of dysplasia were calculated using the odds ratio and the 95% confidence interval. P ASCUS on ThinPrep Papanicolaou smear were identified; 63 patients had ASCUS, reactive, and 63 patients had ASCUS, SIL. The demographic features of both groups were similar. The overall prevalence of dysplasia was 15.9% and was significantly higher among women with ASCUS, SIL, than among women with ASCUS, reactive (25.4% versus 6.4%, P = 0.003). The type of ASCUS cytology (reactive versus SIL), smoking, and history of HPV were significant risk factors for dysplasia (P = 0.003, 0.037, and 0. 042, respectively). The prevalence of dysplasia among women seen in a gynecologic oncology service with ASCUS cytology on ThinPrep Papanicolaou smears is 15.9%. Women with ASCUS favor

Research results reported by OEO summer (1981) student employees of LLNL working with Earth Sciences (K) Division personnel

International Nuclear Information System (INIS)

Doyle, M.C.; Griffith, P.J.; Kreevoy, E.P.; Turner, H.J. III; Tatman, D.A.

1982-01-01

Significant experimental results were achieved in a number of research programs that were carried out during the summer of 1981 by students sponsored by the Office of Equal Opportunity at the Lawrence Livermore National Laboratory. These students were working with Earth Sciences (K) Division personnel. Accomplishments include the following: (1) preparation of post-burn stratigraphic sections for the Hoe Creek III experiment, Underground Coal Gasification project; (2) preparation of miscellaneous stratigraphic sections in the Climax granite near the Spent Fuel Test, Nevada Test Site, for the Waste Isolation Project; (3) confirmation of the applicability of a new theory relating to subsidence (solid matrix movement); (4) experimental confirmation that organic groundwater contaminants produced during an underground coal gasification experiment can be removed by appropriate bacterial treatment; (5) development of data supporting the extension of the Greenville Fault Zone into the Northern Diablo Range (Alameda and Santa Clara Counties, California); (6) completion of a literature review on hazardous waste (current disposal technology, regulations, research needs); (7) preparation of a map showing levels of background seismic noise in the USSR; (8) demonstration of a correlation of explosion size with the P-wave magnitude of the seismic signal produced by the explosion; and (9) reduction of data showing the extent of ground motion resulting from subsidence in the vicinity of the Hoe Creek III experiment, Underground Coal Gasification Project

Research results reported by OEO summer (1981) student employees of LLNL working with Earth Sciences (K) Division personnel

Energy Technology Data Exchange (ETDEWEB)

Doyle, M. C.; Griffith, P. J.; Kreevoy, E. P.; Turner, III, H. J.; Tatman, D. A.

1982-01-01

Significant experimental results were achieved in a number of research programs that were carried out during the summer of 1981 by students sponsored by the Office of Equal Opportunity at the Lawrence Livermore National Laboratory. These students were working with Earth Sciences (K) Division personnel. Accomplishments include the following: (1) preparation of post-burn stratigraphic sections for the Hoe Creek III experiment, Underground Coal Gasification project; (2) preparation of miscellaneous stratigraphic sections in the Climax granite near the Spent Fuel Test, Nevada Test Site, for the Waste Isolation Project; (3) confirmation of the applicability of a new theory relating to subsidence (solid matrix movement); (4) experimental confirmation that organic groundwater contaminants produced during an underground coal gasification experiment can be removed by appropriate bacterial treatment; (5) development of data supporting the extension of the Greenville Fault Zone into the Northern Diablo Range (Alameda and Santa Clara Counties, California); (6) completion of a literature review on hazardous waste (current disposal technology, regulations, research needs); (7) preparation of a map showing levels of background seismic noise in the USSR; (8) demonstration of a correlation of explosion size with the P-wave magnitude of the seismic signal produced by the explosion; and (9) reduction of data showing the extent of ground motion resulting from subsidence in the vicinity of the Hoe Creek III experiment, Underground Coal Gasification Project.

Percepção de crianças hospitalizadas sobre realização de exames Percepción de niños hospitalizados sobre realización de examenes Hospitalized children' perception on exam accomplishment

Directory of Open Access Journals (Sweden)

Virgínia Virgilio Soares

2004-09-01

Full Text Available O estudo teve como objetivo identificar a percepção da criança hospitalizada, em idade escolar, sobre a realização de exames. Foi utilizada a pesquisa de natureza descritiva, predominando a investigação de caráter qualitativo. Os resultados revelaram que as crianças cooperam com os exames apesar do medo. O medo foi relacionado ao temor da dor física, de ser machucado, e ainda, do desconhecido. Considera-se que a criança percebe a realização do exame como parte do seu tratamento e gostaria de receber explicações sobre o procedimento.El estudio tuvo como objetivo identificar la percepción del niño hospitalizado, en edad de ir a la escuela, sobre la realización de exámenes. Fue usada la investigación de naturaleza descriptiva, prevaleciendo la investigación de carácter cualitativo. Los resultados revelaron que los niños colaboran con los exámenes a pesar del miedo. EI miedo se relacionó con el temor al dolor físico, a ser herido, o aún, a lo desconocido. Se considera que el niño percibe la realización del examen como parte del tratamiento e desearía recibir explicaciones sobre el procedimiento.The study had as objective to identify the hospitalized children's perception, in school age, about the accomplishment of exams. The research of descriptive nature was used, prevailing the investigation of qualitative character. The results revealed that the children cooperate with exams despite the fear. The fear was related to the dread of the physical pain, being hurt, or even the unknown. It is considered that the child notes the exam accomplishment as part of his/her treatment and he/she would like to receive explanations about the procedure.

Clinical significance of the fabella

International Nuclear Information System (INIS)

Dodevski, A.; Lazarova-Tosovska, D.; Zhivadinovik, J.; Lazareska, M.

2012-01-01

Full text: Introduction: There is variable number of sesamoid bones in the human body; one of them is fabella, located in the tendon of the gastrocnemius muscle. Aim of this study was to investigate the frequency of occurrence of fabella in the Macedonian population and to discuss about clinical importance of this bone. Materials and methods: We retrospectively examined radiographs of 53 patients who had knee exams undertaken for a variety of clinical reasons, performed as a part of their medical treatment. Over a time span of six months, 53 patients (38 males and 15 females, age range 19-60 years, mean age of 36.7±12.3 years) were examined. Results: In seven (13.2%) patients of 53 analyzed reports, fabella was found in the lateral tendon of gastrocnemius muscle. We did not find a significant gender or side difference in the appearance of fabella. Conclusion: Although anatomic studies emphasized a lack of significance of the fabella, this bone has been associated with a spectrum of pathology affecting the knee as fabellar syndrome, perineal nerve injury and fracture. We should think of this sesamoid bone while performing diagnostic and surgical procedures

New compounds for neutron capture therapy (NCT) and their significance

International Nuclear Information System (INIS)

Fairchild, R.G.; Bond, V.P.

1982-01-01

Clearly the most effective tumor therapy would be obtained by the selective targeting of cytotoxic agents to tumor cells. Although many biomolecules are known to be taken up in tumors, the targeting of cytotoxic agents to tumors is limited by the fact that other essential cell pools compete with equal or even greater effectiveness. The approach of delivering stable non-toxic isotopes to tumor, with activation by means of an external radiation beam, is advantageous for two reasons: (1) it obviates problems associated with high uptake of isotopes in normal tissues, as these cell pools can be excluded from the radiation field, and (2) the general tumor area can be included in the activating beam field; thus, the possibility exists that all microscopic tumor extensions can be irradiated. As long as range of reaction products is short, dose will be restricted to the tumor, with a resultant high therapeutic ratio. This method can be accomplished with either photon activation therapy (PAT) or Neutron Capture Therapy (NCT), the latter will be emphasized here. The range of the high LET, low OER particles from the 10 B(n,α) 7 Li reaction is approx. 10 μm, or one cell diameter; hence this reaction is optimal for cell killing. A number of biomolecules have been investigated as possible vehicles for transport of boron to tumors, including phenothiazines, thiouracils, porphyrins, nucleosides, and amino acids. Biodistributions of these compounds show selective concentration in tumor adequate for therapy. The biological halflives are in the order of days, allowing the possibility of fractionated or protracted irradiations. The radiobiological and physical implication of these parameters on NCT are discussed. The possibility of using an approximately-monoenergetic, scandium-filtered beam of about 2 keV, to reduce the dose from background radiations by about 85%, is also discussed

The EU Rules on Labelling of Genetically Modified Foods: Mission accomplished?

DEFF Research Database (Denmark)

Andersen, Lars Bracht

2010-01-01

of GMO related content in a food product is in fact an appropriate measure to protect consumer interests. Furthermore, the EU labelling rules may prove to be a trade obstacle causing conflict in the EU’s trade relations with third countries. The labelling rules will most likely be considered a trade......In 2003 the EU adopted new rules regulating all aspects of placing genetically modified foods on the market. The rules significantly enhance the scope of the labelling requirement in an attempt to accommodate consumer demand, but it is debatable whether or not a labelling requirement in the case...

Gas Research Institute research program summary: Goals and accomplishments

International Nuclear Information System (INIS)

1991-07-01

Gas Research Institute's research and development programs pursue technologies that maximize the value of gas energy services while minimizing the cost of supplying and delivering gaseous fuels. Four program areas, Supply Options, End Use, Gas Operations, and Crosscutting Research, are described in the report, together with related project titles and numbers. Also included are summaries of 1990 research results, research collaboration and supported work, and patents and licensing agreements. Glossaries of budget and program terms and of acronyms and abbreviations often used in the GRI literature are added

The significance of 'facilitator as a change agent'--organisational learning culture in aged care home settings.

Science.gov (United States)

Grealish, Laurie; Henderson, Amanda; Quero, Fritz; Phillips, Roslyn; Surawski, May

2015-04-01

To explore the impact of an educational programme focused on social behaviours and relationships on organisational learning culture in the residential aged care context. The number of aged care homes will continue to rise as the frail older elderly live longer, requiring more formal care and support. As with other small- to medium-sized health services, aged care homes are faced with the challenge of continuous development of the workforce and depend upon registered nurses to lead staff development. A mixed-method evaluation research design was used to determine the impact of an educational programme focused on social aspects of learning on organisational learning culture. One hundred and fifty-nine (pre) and 143 (post) participants from three aged care homes completed the Clinical Learning Organisational Culture survey, and three participant-researcher registered nurse clinical educators provided regular journal entries for review. While each site received the same educational programme over a six-month period, the change in organisational learning culture at each site was notably different. Two aged care homes had significant improvements in affiliation, one in accomplishment and one in recognition. The educators' journals differed in the types of learning observed and interventions undertaken, with Eucalyptus focused on organisational change, Grevillea focused on group (student) change and the Wattle focused on individual or situational change. Clinical educator activities appear to have a significant effect on organisational learning culture, with a focus on the organisational level having the greatest positive effect on learning culture and on individual or situational level having a limited effect. Clinical educator facilitation that is focused on organisational rather than individual interests may offer a key to improving organisational learning culture. © 2014 John Wiley & Sons Ltd.

Clinical significance of low result of 1-h 50-g glucose-challenge test in pregnant women.

Science.gov (United States)

Oawada, Nozomi; Aoki, Shigeru; Sakamaki, Kentaro; Obata, Soichiro; Seki, Kazuo; Hirahara, Fumiki

2018-01-31

The objective of this study is to examine the effect of low-glucose value on the 1-h 50-g glucose challenge test (GCT) on neonatal body weight in low-risk Asian singleton pregnant women. We retrospectively analyzed women who delivered a singleton neonate at term at a tertiary center and underwent GCT at 24-28 weeks of gestation between June 2001 and June 2015. The low GCT group was defined as low-birth weight, and macrosomia. The χ 2 test, Fisher's exact test, and Student's t test were used. There were 313 low GCT groups and 4611 control. The low GCT group were younger, had lower prepregnancy body weight, higher stature, and lower prepregnancy body mass index (BMI). After adjusting these variables, the low GCT group had a lower rate of LGA and a higher rate of SGA. Neonatal body weight is more influenced by maternal physique than by low GCT result (standardized coefficient (β); GCT 0.071, height 0.188, prepregnancy BMI 0.143). Neonatal body weight was only slightly influenced by low GCT result, but markedly influenced by maternal physique, such as height and prepregnancy BMI.

Clinical significance of atypical squamous cells of undetermined significance in detecting preinvasive cervical lesions in post- menopausal Turkish women.

Science.gov (United States)

Tokmak, Aytekin; Guzel, Ali Irfan; Ozgu, Emre; Oz, Murat; Akbay, Serap; Erkaya, Salim; Gungor, Tayfun

2014-01-01

To evaluate the clinical significance of atypical squamous cells of undetermined significance (ASCUS) in PAP test in post-menopausal women and compare with reproductive age women. A total of 367 patients who referred to our gynecologic oncology clinic were included to the study between September 2012 and August 2013. Data for 164 post-menopausal (group 1) and 203 pre-menopausal (group 2) women with ASCUS cytology were evaluated retrospectively. Immediate colposcopy and endocervical curettage was performed for both groups and conization for all women with a result suggestive of CIN2-3. Histopathological results and demographic features of patients were compared between the two groups. Mean age of the patients was 54.6±6.5 years in group 1 and 38±6.6 years in group 2. Some 14 (8.5%) of post- menopausal women and 36 (17.7%) of pre-menopausal women were current smokers (p=011). Totals of 38 (23.2%) post-menopausal and 64 (31.5%) pre-menopausal women were assessed for HPV-DNA. High risk HPV was detected in 7 (4.3%) and 21 (10.3%), respectively (p=0.029). Final histopathological results recorded were normal cervix, low grade cervical intra-epithelial neoplasia (CIN 1), and high grade cervical intra-epithelial neoplasia (CIN2-3). In group 1 results were 84.8%, 12.2% and 1.8%, respectively, and in group 2 were 71.9%, 23.2% and 4.9%. There were no cases of micro invasive or invasive cervical carcinoma in either group. Two cases were detected as endometrial carcinoma in the menopausal group (1.2%). In current study we found that preinvasive lesions were statistically significantly higher in pre-menopausal women than post- menopausal women with ASCUS. Cervicitis was more common in menopausal women. Therefore, we think that in case of ASCUS in a post-menopausal woman there is no need for radical management.

Reports of the research results for the peaceful uses of atomic energy, no. 19

International Nuclear Information System (INIS)

1980-01-01

Many valuable results have been obtained by the tests and researches concerning the peaceful utilization of atomic energy, and they accomplished major role in the promotion of the peaceful utilization of atomic energy in Japan. In this report, the results of the tests and researches on the peaceful utilization of atomic energy carried out by national research institutes and others in 1978 fiscal year are outlined. It is desirable to deepen understandings further on the recent trend and results of the tests and researches with this book. The report is divided into the following chapters: nuclear fusion, safety research (technological safety research, environmental radioactivity safety research), food irradiation, countermeasures to cancers, agriculture, forestry and fishery (fertilized soil, quality improvement, farm product protection, breeding improvement), medicine (diagnosis and therapy, pharmaceuticals, environmental hygiene, application to living body pathology), mining and industry (radiation chemistry, radiation measurement, process analysis), power utilization (nuclear reactor materials, nuclear ships), civil engineering, radioactivation analysis, and injury prevention research. (Kako, I.)

Confidence intervals permit, but don't guarantee, better inference than statistical significance testing

Directory of Open Access Journals (Sweden)

Melissa Coulson

2010-07-01

Full Text Available A statistically significant result, and a non-significant result may differ little, although significance status may tempt an interpretation of difference. Two studies are reported that compared interpretation of such results presented using null hypothesis significance testing (NHST, or confidence intervals (CIs. Authors of articles published in psychology, behavioural neuroscience, and medical journals were asked, via email, to interpret two fictitious studies that found similar results, one statistically significant, and the other non-significant. Responses from 330 authors varied greatly, but interpretation was generally poor, whether results were presented as CIs or using NHST. However, when interpreting CIs respondents who mentioned NHST were 60% likely to conclude, unjustifiably, the two results conflicted, whereas those who interpreted CIs without reference to NHST were 95% likely to conclude, justifiably, the two results were consistent. Findings were generally similar for all three disciplines. An email survey of academic psychologists confirmed that CIs elicit better interpretations if NHST is not invoked. Improved statistical inference can result from encouragement of meta-analytic thinking and use of CIs but, for full benefit, such highly desirable statistical reform requires also that researchers interpret CIs without recourse to NHST.

Legal significance of environmental protection in foreign investments law

Directory of Open Access Journals (Sweden)

Divljak Drago

2013-01-01

Full Text Available The paper presents the analysis of conceptual interaction between foreign investments and environmental protection, as well as its legal repercussions. A part of the paper has been directed towards critical review of the attempt of legal regulating of these relationships at an international level. A special attention was paid to the treatment of the environment in our foreign investments law. It can be concluded that the dominant paradigm of the future direction of development in this field is going to be the strengthening of the bond between international investments and environmental protection. It is insisted on the attitude that our law needs to approach adequately to the matter of legal valorization of the environmental protection issue. This requires the creating of a complex, coherent approach that should be based on adequate legal superstructure and amendments to the existing Law on Foreign Investments. The main direction of changes implies that the current obligation of foreign investors in this field should be raised onto a higher level and foreign investments should be placed in the function of accomplishing of the concept of sustainable development. However, such an approach has to be accompanied by appropriate mechanism of control and supervision in the given field, if its full effectiveness is to be achieved.

Clinical Significance of the Number of Depressive Symptoms in Major Depressive Disorder: Results from the CRESCEND Study.

Science.gov (United States)

Park, Seon-Cheol; Sakong, Jeongkyu; Koo, Bon Hoon; Kim, Jae-Min; Jun, Tae-Youn; Lee, Min-Soo; Kim, Jung-Bum; Yim, Hyeon-Woo; Park, Yong Chon

2016-04-01

Our study aimed to establish the relationship between the number of depressive symptoms and the clinical characteristics of major depressive disorder (MDD). This would enable us to predict the clinical significance of the number of depressive symptoms in MDD patients. Using data from the Clinical Research Center for Depression (CRESCEND) study in Korea, 853 patients with DSM-IV MDD were recruited. The baseline and clinical characteristics of groups with different numbers of depressive symptoms were compared using the χ(2) test for discrete variables and covariance (ANCOVA) for continuous variables. In addition, the scores of these groups on the measurement tools were compared by ANCOVA after adjusting the potential effects of confounding variables. After adjusting the effects of monthly income and history of depression, a larger number of depressive symptoms indicated higher overall severity of depression (F [4, 756] = 21.458, P depressive symptoms (F [4, 767] = 19.145, P depressive symptoms can be used as an index of greater illness burden in clinical psychiatry.

Prognostic significance of diagnostic laparoscopy for spontaneous fertility

NARCIS (Netherlands)

Mol, B. W.; Swart, P.; Bossuyt, P. M.; van der Veen, F.

1999-01-01

OBJECTIVE: To determine the prognostic significance of laparoscopy results for fertility outcome. STUDY DESIGN: Consecutive patients undergoing hysterosalpingography and laparoscopy for subfertility in our department between May 1985 and November 1987 were identified from medical records. The impact

Prognostic significance of precordial ST segment depression during inferior myocardial infarction in the thrombolytic era: Results in 16,521 patients

NARCIS (Netherlands)

E.D. Peterson; W.R. Hathaway; K.M. Zabel; K.S. Pieper (Karen); C.B. Granger (Christopher); G.S. Wagner (Galen); E.J. Topol (Eric); E.R. Bates (Eric); M.L. Simoons (Maarten); R.M. Califf (Robert)

1996-01-01

textabstractObjectives. We examined the prognostic significance of precordial ST segment depression among patients with an acute inferior myocardial infarction. Background. Although precordial ST segment depression has been associated with a poor prognosis, this correlation has not been adequately

Clinical results of the transjugular intrahepatic portosystemic shunt

Energy Technology Data Exchange (ETDEWEB)

Park, Auh Whan; Sim, Jae In; Ryeom, Hun Kyu; Kim, Yong Joo [Kyungpook National University Hospital, Daegu (Korea, Republic of)

1994-04-15

To evaluate the clinical results of transjugular intrahepatic portosystemic shunt(TIPS) for the control of variceal bleeding. TIPS creation was attempted in 23 patients with endoscopically confirmed variceal bleeding. Most patients had multiple episodes of bleeding in the past and have been treated with multiple endoscopic sclerotherapies. Pre-and post-procedural hepatic and portal vein pressures were measured. After creation of TIPS patients were followed up at regular intervals. TIPS has been successfully accomplished in 22 of 23 patients using Wallstent(n = 21) and Strecker stent(n = 1). Immediate bleeding control was achieved in all patients with shunt creation. No procedure-related complication was noted. Portal vein pressure was reduced from 30.7 {+-} 5.8 mmHg to 20.8 {+-} 4.7 mmHg. The mean pressure gradient of portosystemic shunt dropped from 22.8 {+-} 6.0 prior to TIPS to 12.2 {+-} 4.1 immediately after. During the follow-up period (6-556 days, mean; 10 months), seven patients died; progressive hepatic failure (n 4), variceal rebleeding (n = 2), and respiratory failure(n = 1). Hepatic encephalopathy after TIPS was noted in 7 patients(31.8%). Variceal rebleeding occurred in 3 patients(13.6%). The remaining 15 patients have survived an average of 11 months. This results suggest that TIPS is a safe and effective method for lowering portal pressure and controlling variceal bleeding. Furthermore if these initial results are encouraged by further long-term observation, TIPS could replace endoscopic and risky surgical intervention.

A single amino acid change (Y318F) in the L-arabitol dehydrogenase (LadA) from Aspergillus niger results in a significant increase in affinity for D-sorbitol

Science.gov (United States)

2009-01-01

Background L-arabitol dehydrogenase (LAD) and xylitol dehydrogenase (XDH) are involved in the degradation of L-arabinose and D-xylose, which are among the most abundant monosaccharides on earth. Previous data demonstrated that LAD and XDH not only differ in the activity on their biological substrate, but also that only XDH has significant activity on D-sorbitol and may therefore be more closely related to D-sorbitol dehydrogenases (SDH). In this study we aimed to identify residues involved in the difference in substrate specificity. Results Phylogenetic analysis demonstrated that LAD, XDH and SDH form 3 distinct groups of the family of dehydrogenases containing an Alcohol dehydrogenase GroES-like domain (pfam08240) and likely have evolved from a common ancestor. Modelling of LadA and XdhA of the saprobic fungus Aspergillus niger on human SDH identified two residues in LadA (M70 and Y318), that may explain the absence of activity on D-sorbitol. While introduction of the mutation M70F in LadA of A. niger resulted in a nearly complete enzyme inactivation, the Y318F resulted in increased activity for L-arabitol and xylitol. Moreover, the affinity for D-sorbitol was increased in this mutant. Conclusion These data demonstrates that Y318 of LadA contributes significantly to the substrate specificity difference between LAD and XDH/SDH. PMID:19674460

Evaluating significance in linear mixed-effects models in R.

Science.gov (United States)

Luke, Steven G

2017-08-01

Mixed-effects models are being used ever more frequently in the analysis of experimental data. However, in the lme4 package in R the standards for evaluating significance of fixed effects in these models (i.e., obtaining p-values) are somewhat vague. There are good reasons for this, but as researchers who are using these models are required in many cases to report p-values, some method for evaluating the significance of the model output is needed. This paper reports the results of simulations showing that the two most common methods for evaluating significance, using likelihood ratio tests and applying the z distribution to the Wald t values from the model output (t-as-z), are somewhat anti-conservative, especially for smaller sample sizes. Other methods for evaluating significance, including parametric bootstrapping and the Kenward-Roger and Satterthwaite approximations for degrees of freedom, were also evaluated. The results of these simulations suggest that Type 1 error rates are closest to .05 when models are fitted using REML and p-values are derived using the Kenward-Roger or Satterthwaite approximations, as these approximations both produced acceptable Type 1 error rates even for smaller samples.

Significant biases affecting abundance determinations

Science.gov (United States)

Wesson, Roger

2015-08-01

I have developed two highly efficient codes to automate analyses of emission line nebulae. The tools place particular emphasis on the propagation of uncertainties. The first tool, ALFA, uses a genetic algorithm to rapidly optimise the parameters of gaussian fits to line profiles. It can fit emission line spectra of arbitrary resolution, wavelength range and depth, with no user input at all. It is well suited to highly multiplexed spectroscopy such as that now being carried out with instruments such as MUSE at the VLT. The second tool, NEAT, carries out a full analysis of emission line fluxes, robustly propagating uncertainties using a Monte Carlo technique.Using these tools, I have found that considerable biases can be introduced into abundance determinations if the uncertainty distribution of emission lines is not well characterised. For weak lines, normally distributed uncertainties are generally assumed, though it is incorrect to do so, and significant biases can result. I discuss observational evidence of these biases. The two new codes contain routines to correctly characterise the probability distributions, giving more reliable results in analyses of emission line nebulae.

The fast trigger electronics of the lead/scintillating fiber calorimeter SpaCal of the H1 experiment at HERA: accomplishment, results of test beam measurements at CERN and first results at HERA

International Nuclear Information System (INIS)

Spielmann, Stephan

1996-01-01

The studies presented in this thesis cover parts of the project to improve the H1 detector at the electron-proton collider HERA. The main goal of this improvement was to build a lead/scintillating fiber calorimeter (SpaCal) and its associate trigger and read-out electronics. The description and the analysis of measurements with a calorimeter prototype and its electronics are presented with respect to the performance requirements for the project. This measurement realized at a CERN test beam facility have shown that an on-line selection of physics events out of background events can be achieved with a time-of-flight measurement. The efficiency of the trigger is higher than 99 percent independent of the particles' impact points. The feasibility of electron/pion separation on the one percent level is also shown. In 1995 the SpaCal calorimeter was integrated in the H1 detector. A detailed description of its associate electronics is given and the results on the trigger's performance for the first year of data taking are presented. (author) [fr

The low risk of precancer after a screening result of human papillomavirus-negative/atypical squamous cells of undetermined significance papanicolaou and implications for clinical management.

Science.gov (United States)

Gage, Julia C; Katki, Hormuzd A; Schiffman, Mark; Castle, Philip E; Fetterman, Barbara; Poitras, Nancy E; Lorey, Thomas; Cheung, Li C; Behrens, Catherine; Sharma, Abha; Zhao, Fang-Hui; Cuzick, Jack; Yang, Zi Hua; Kinney, Walter K

2014-11-01

Different US practice guidelines have conflicting recommendations for when women should return after a screening result of human papillomavirus (HPV)-negative with an equivocal Papanicolaou (Pap) result of atypical squamous cells of undetermined significance (ASC-US) (ie, return in either 3 or 5 years). One way to determine management is to compare the risk of precancer/cancer after an HPV-negative/ASC-US result with the risks after other negative screening results. For example, if the risk after an HPV-negative/ASC-US result was similar to the risk after a negative Pap test, a 3-year return would be preferred because guidelines agree that women with negative Pap test results should return in 3 years. Alternatively, if the risk after an HPV-negative/ASC-US result is similar to that after a cotest-negative result (HPV negative/Pap test negative), a 5-year return would be preferred because guidelines agree that women testing cotest negative should return in 5 years. The authors compared risks of cervical intraepithelial neoplasia of grade 3 or higher (CIN3+) and cervical cancer among women aged 30 years to 64 years at Kaiser Permanente Northern California with the following test results from 2003 through 2012: 17,191 women testing HPV negative/ASC-US; 980,268 women testing Pap test negative (regardless of HPV result); and 892,882 women testing cotest negative. The 5-year CIN3+ and cancer risks after an HPV-negative/ASC-US result were closer to the risks after a negative Pap test result (CIN3+: 0.48% vs 0.31% [P =.0019]; and cancer: 0.043% vs 0.031% [P =.4]) than after a negative cotest (CIN3+: 0.48% vs 0.11% [P<.0001]; and cancer: 0.043% vs 0.014% [P =.016]). Women testing HPV negative/ASC-US were found to have precancer/cancer risks that were more closely aligned with women with negative Pap test results, suggesting that women testing HPV negative/ASC-US should be managed similarly to women testing negative on Pap tests with a 3-year return for screening. © 2014

Prevalence of significant bacteriuria among symptomatic and ...

African Journals Online (AJOL)

Data were analyzed using the Statistical Package for Social Sciences (SPSS) version 16.0 (SPSS, Inc., Chicago, Ill). Results: A total of 100 consenting participants were recruited into the study. The mean age was: 23.42 ± 8.31 years and a range of 14‑50 years. Only 9% (9/100) had significant bacteriuria while 44.4% (4/9) ...

Ontario Power Generation Nuclear: results and opportunities

International Nuclear Information System (INIS)

Dermarkar, F.

2006-01-01

This paper describes the accomplishments of Ontario Power Generation (OPG) Nuclear and outlines future opportunities. OPG's mandate is to cost effectively produce electricity, while operating in a safe, open and environmentally responsible manner. OPG's nuclear production has been increasing over the past three years - partly from the addition of newly refurbished Pickering A Units 1 and 4, and partly from the increased production from Darlington and Pickering B. OPG will demonstrate its proficiency and capability in nuclear by continuing to enhance the performance and cost effectiveness of its existing operations. Its priorities are to focus on performance excellence, commercial success, openness, accountability and transparency

Dual purpose or not? The significant factors

International Nuclear Information System (INIS)

Bak, W.; Roland, V.

1999-01-01

The development of spent fuel storage systems requires consideration of many factors in making design decisions. A significant issue affecting the design is the need to incorporate transportability of the canister or cask system design, which results in major changes to the storage system design. This paper presents a review of the significant factors affecting storage system design to incorporate transportation requirements and looks at the trends in both the United States and Europe where Transnucleaire and its US affiliated companies Transnuclear Inc., Transnuclear West and PacTec are active. A discussion is also presented relative to the pros and cons of whether the spent fuel storage system vendor should anticipate these transportation needs in the design of their systems. (author)

Accomplishments of Naturalistic Decision Making Research and Applications to Emerging Defense Challenges

Science.gov (United States)

2015-07-27

disease if responsible parties cut corners or make wrong decisions for their own convenience? The moral here is the importance of non-expert decision...values, morality , etc.). Create Methods for "Rapidized Cognitive Task Analysis" (RCTA) CTA of various methodological types has a significant track...For measurement at the work system level the most important measures will be relativized , compound measures. So, for example, a measure of

Your Chi-Square Test Is Statistically Significant: Now What?

Science.gov (United States)

Sharpe, Donald

2015-01-01

Applied researchers have employed chi-square tests for more than one hundred years. This paper addresses the question of how one should follow a statistically significant chi-square test result in order to determine the source of that result. Four approaches were evaluated: calculating residuals, comparing cells, ransacking, and partitioning. Data…

The baffle-barrel-bolting analysis program: evolution and technical accomplishments

International Nuclear Information System (INIS)

Schwirian, R.E.; Forsyth, D.R.; Snyder, M.D.; Bhandari, D.R.; Barsic, J.A.; Rabenstein, W.D.

2001-01-01

In Westinghouse pressurized water reactors (PWR) the reactor core is surrounded by baffle plates, which provide lateral restraint for the fuel assemblies at the core boundary. Baffle plates are attached to horizontal supports called former plates by baffle-former bolts. The formers are attached to the core barrel which also provides vertical support for the core. The B3 analysis program addresses the possibility of reduced baffle-former bolting in Westinghouse U.S. domestic plant designs with respect to the relevant design criteria. Since safety is the overriding motivation for the program, faulted events have received the most in-depth attention. This focus has been reinforced by the fact that the loads produced by the loss-of-coolant-accident (LOCA) have usually been the most limiting of all those considered. Consequently, much of the presentation below deals with the development of analysis techniques and acceptance criteria to demonstrate that LOCA-induced loads on the bolts and the fuel assemblies will be acceptable with significantly reduced baffle-former bolting. A discussion of the other faulted, normal, and upset analyses performed as part of the program will also be presented. (author)

Caveats for using statistical significance tests in research assessments

DEFF Research Database (Denmark)

Schneider, Jesper Wiborg

2013-01-01

controversial and numerous criticisms have been leveled against their use. Based on examples from articles by proponents of the use statistical significance tests in research assessments, we address some of the numerous problems with such tests. The issues specifically discussed are the ritual practice......This article raises concerns about the advantages of using statistical significance tests in research assessments as has recently been suggested in the debate about proper normalization procedures for citation indicators by Opthof and Leydesdorff (2010). Statistical significance tests are highly...... argue that applying statistical significance tests and mechanically adhering to their results are highly problematic and detrimental to critical thinking. We claim that the use of such tests do not provide any advantages in relation to deciding whether differences between citation indicators...

A History of the Discovery of Random X Chromosome Inactivation in the Human Female and its Significance

Directory of Open Access Journals (Sweden)

Sophia Balderman

2011-07-01

Full Text Available Genetic determinants of sex in placental mammals developed by the evolution of primordial autosomes into the male and female sex chromosomes. The Y chromosome determines maleness by the action of the gene SRY, which encodes a protein that initiates a sequence of events prompting the embryonic gonads to develop into testes. The X chromosome in the absence of a Y chromosome results in a female by permitting the conversion of the embryonic gonads into ovaries. We trace the historical progress that resulted in the discovery that one X chromosome in the female is randomly inactivated in early embryogenesis, accomplishing approximate equivalency of X chromosome gene dosage in both sexes. This event results in half of the somatic cells in a tissue containing proteins encoded by the genes of the maternal X chromosome and half having proteins encoded by the genes of the paternal X chromosome, on average, accounting for the phenotype of a female heterozygote with an X chromosome mutation. The hypothesis of X chromosome inactivation as a random event early in embryogenesis was first described as a result of studies of variegated coat color in female mice. Similar results were found in women using the X chromosome-linked gene, glucose-6-phosphate dehydrogenase, studied in red cells. The random inactivation of the X chromosome-bearing genes for isoenzyme types A and B of glucose-6-phosphate dehydrogenase was used to establish the clonal origin of neoplasms in informative women with leiomyomas. Behind these discoveries are the stories of the men and women scientists whose research enlightened these aspects of X chromosome function and their implication for medicine.

No significant fuel failures (NSFF)

International Nuclear Information System (INIS)

Domaratzki, Z.

1979-01-01

It has long been recognized that no emergency core cooling system (ECCS) could be absolutely guaranteed to prevent fuel failures. In 1976 the Atomic Energy Control Board decided that the objective for an ECCS should be to prevent fuel failures, but if the objective could not be met it should be shown that the consequences are acceptable for dual failures comprising any LOCA combined with an assumed impairment of containment. Out of the review of the Bruce A plant came the definition of 'no significant fuel failures': for any postulated LOCA combined with any one mode of containment impairment the resultant dose to a person at the edge of the exclusion zone is less than the reference dose limits for dual failures

Quality of life during orthopaedic training and academic practice: part 2: spouses and significant others.

Science.gov (United States)

Sargent, M Catherine; Sotile, Wayne; Sotile, Mary O; Rubash, Harry; Barrack, Robert L

2012-10-03

Orthopaedic residents and attending physicians who report having a supportive spouse show lower levels of burnout and psychological distress than those without supportive spouses. However, little is known about the experiences of the spouses. This nationwide study examines burnout, psychological distress, and marital satisfaction of the spouses and significant others (collectively referred to hereafter as spouses) of orthopaedists in training and in orthopaedic practice in an academic setting. Employing previously reported methodology, 259 spouses of orthopaedic residents and 169 spouses of full-time orthopaedic faculty completed a voluntary, anonymous survey. The survey included three validated instruments (the Maslach Burnout Inventory, the General Psychological Health Questionnaire-12, and the Revised Dyadic Adjustment Scale) and three novel question sets addressing demographic information, relationship issues, stress, and work/life balance. Psychological distress was noted in 18% of resident spouses compared with only 10% of faculty spouses (p = 0.014). Resident spouses reported greater loneliness (p < 0.0009) and stress (p = 0.03) than faculty spouses. Among working spouses, 30% of resident spouses and 13% of faculty spouses showed high levels of emotional exhaustion (p < 0.003). Twenty-eight percent of employed resident spouses and 5% of employed faculty spouses showed problematic levels of depersonalization (p < 0.0001). Twenty-six percent of employed resident spouses and 12% of employed faculty spouses showed a diminished sense of personal accomplishment (p = 0.012). Marital satisfaction was high for both resident and faculty spouses. Decreased satisfaction correlated with excessive mate irritability and fatigue that precluded their mate's involvement in family activities. A gratifying sex life, full-time work outside the home, and spending more than ninety minutes a day with their mate correlated significantly with marital satisfaction. Many orthopaedic

Developing a typology of patient-generated behavioral goals for cognitive behavioral therapy for chronic pain (CBT-CP): classification and predicting outcomes.

Science.gov (United States)

Heapy, Alicia A; Wandner, Laura; Driscoll, Mary A; LaChappelle, Kathryn; Czlapinski, Rebecca; Fenton, Brenda T; Piette, John D; Aikens, James E; Janevic, Mary R; Kerns, Robert D

2018-04-01

Patient-generated treatment goals describe what patients value, yet the content of these goals, and the relationship among goal types, goal accomplishment, and treatment outcomes has received little examination. We used inductive sorting to categorize patient-generated goals made by 147 adults receiving cognitive-behavioral therapy for chronic pain. The resulting goal categories were: Physical Activity (29.0%), Functional Status (24.6%), Wellness (16.3%), Recreational Activities (11.3%), House/Yard Work (9.7%), Socializing (7.1%), and Work/School (2.0%). Next, we examined associations between number of goals by category, goal accomplishment, and clinically meaningful improvements in pain-related interference, pain intensity and depressive symptoms. Improvement in all outcome domains was related to goal accomplishment. Additionally, depressive symptoms were related to number of Physical Activity, House/Yard Work, Recreational Activities, and Wellness goals, whereas improved pain-intensity was significantly related to House/Yard Work. Classifying patient-generated goals facilitates investigation of the relationships among goal type, goal accomplishment and treatment outcomes.

Results of the Annual DOD/FAI Acquisition Research Symposium (9th)

Science.gov (United States)

1980-10-01

decision space to include the feasible alterna- tives is usually accomplished to some degree by the DM (perhaps subconsciously ) using some version of...approval outside of the PPBS time frame can be funded by reprogramming actions when appropriate. The analysis of the mission area is an excellent...was deferred. This means funds are tied up that could not be deobligated and reprogrammed to satisfy other requirements. GENERAL OBJECTIVES In

Acute and Chronic Fetal Anemia as a Result of Fetomaternal Hemorrhage

OpenAIRE

Singh, Paul; Swanson, Tara

2014-01-01

Introduction. Fetomaternal hemorrhage represents a transfer of fetal blood to the maternal circulation. Although many etiologies have been described, most causes of fetomaternal hemorrhage remain unidentified. The differentiation between acute and chronic fetomaternal hemorrhage may be accomplished antenatally and may influence perinatal management. Case. A 36-year-old gravida 6 para 3 presented at 37 and 5/7 completed gestational weeks with ultrasound findings suggestive of chronic fetal ane...

Results and development prospects for the Cernavoda NPP

International Nuclear Information System (INIS)

Rotaru, Ioan

2001-01-01

The new competitive market in the power sector offers favorable conditions for continual developing of Nuclear Power in Romania. The principal arguments in this respect are: the CANDU technology is a western technology recognized world wide both for its operation reliability and its economical performances. The results obtained by Cernavoda NPP Unit 1 over a period of four years and a half commercial operation confirms the validity of the CANDU project in Romania in the new conditions of competitive market. Accomplishing the Unit 2 of Cernavoda NPP represents for the time being one of the most cost-effective investment in the Romanian power sector. Also, the participation of the local industry to the project implementation is important as it ensures the initial heavy water and nuclear fuel charging, specific materials and equipment production, design and construction works, etc. Heaving in view all these favorable arguments, the construction of Unit 2 of Cernavoda NPP represents one of the highest priorities of the State Budget of the present administration in year 2001. The Nuclear Power Project in Romania, based on CANDU technology meets national as well as EU regulations concerning nuclear power and as such its development poses no significant problems both in the context of EU extension and in the frame of the developing competitive market in the power sector. For SNN SA the main objectives in view for the next stage are: operating Cernavoda NPP Unit 1 in conditions of highest nuclear safety and economical efficiency; finalizing the Cernavoda NPP Unit 2 and creation of an organisation for operating the two units; promoting of a functional system characteristic to the competitive market economy and open to privatization; creating opportunities for exporting electrical energy. The contribution contains the following sections: 1. General overlook; 2. Performance of the power production in the year 2000; 2.1. Unit 1 of Cernavoda NPP; 2.2. Nuclear Fuel Plant

Sandia Technology: Engineering and science accomplishments, February 1995

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-02-01

Sandia National Laboratories is one of the Department of Energy`s primary research and development laboratories. Our essential mission is to support the national interests of the US in defense, energy, and the environment. Managed by Martin Marietta Corporation for DOE, Sandia focuses its resources on problems of national interest that require the integration of science and technology for their solution. We all hope that this period of sweeping alterations in international affairs will result in a successful transition from the Cold War to a period of sustainable global security and prosperity. In the meantime, our nation`s interests are best served by continued commitment to Sandia`s traditional responsibilities. Nonetheless, as momentous developments are reshaping the world, Sandia is also changing from its beginning as a closed operation concentrating on classified defense programs, Sandia has become a more accessible resource that focuses on research and development partnerships with industry and universities as a way to ensure continued success in DOE`s evolving core mission area of nuclear weapons, energy, environment, and the basis sciences. Through these collaborative efforts, Sandia and its partners are also benefiting the economic competitiveness of our nation. Sandia places a special emphasis on working with small businesses as both technology transfer partners and suppliers of goods and services. We are also reaching out the the larger community surrounding Sandia, striving to provide technological solution and accurate information to meet community needs. We believe that the dialogue we are creating will benefit Sandia, the community, and the nation. Our goal is to render `` exceptional service in the national interest`` by returning maximum value on the investment in the labs. As you review this document, look for new ways in which Sandia can contribute to the solution of problems facing our nation.

Investigating the life-span of cork products through a longitudinal approach with users- Interim results

NARCIS (Netherlands)

Da Silva Pereira, A.C.; Brezet, J.C.; Pereira, H.; Vogtlander, J.G.

2012-01-01

Products with long life-spans are generally preferred form an environmental perspective. This paper addresses the longevity of cork products, and the respective influencing aspects. This is accomplished through a longitudinal study where several cork products are used, and at different moments in

Addition of 2-(ethylamino)acetonitrile group to nitroxoline results in significantly improved anti-tumor activity in vitro and in vivo.

Science.gov (United States)

Mitrović, Ana; Sosič, Izidor; Kos, Špela; Tratar, Urša Lampreht; Breznik, Barbara; Kranjc, Simona; Mirković, Bojana; Gobec, Stanislav; Lah, Tamara; Serša, Gregor; Kos, Janko

2017-08-29

Lysosomal cysteine peptidase cathepsin B, involved in multiple processes associated with tumor progression, is validated as a target for anti-cancer therapy. Nitroxoline, a known antimicrobial agent, is a potent and selective inhibitor of cathepsin B, hence reducing tumor progression in vitro and in vivo . In order to further improve its anti-cancer properties we developed a number of derivatives using structure-based chemical synthesis. Of these, the 7-aminomethylated derivative (compound 17 ) exhibited significantly improved kinetic properties over nitroxoline, inhibiting cathepsin B endopeptidase activity selectively. In the present study, we have evaluated its anti-cancer properties. It was more effective than nitroxoline in reducing tumor cell invasion and migration, as determined in vitro on two-dimensional cell models and tumor spheroids, under either endpoint or real time conditions. Moreover, it exhibited improved action over nitroxoline in impairing tumor growth in vivo in LPB mouse fibrosarcoma tumors in C57Bl/6 mice. Taken together, the addition of a 2-(ethylamino)acetonitrile group to nitroxoline at position 7 significantly improves its pharmacological characteristics and its potential for use as an anti-cancer drug.

Near-field performance assessment for a low-activity waste glass disposal system: laboratory testing to modeling results

International Nuclear Information System (INIS)

McGrail, B.P.; Bacon, D.H.; Icenhower, J.P.; Mann, F.M.; Puigh, R.J.; Schaef, H.T.; Mattigod, S.V.

2001-01-01

Reactive chemical transport simulations of glass corrosion and radionuclide release from a low-activity waste (LAW) disposal system were conducted out to times in excess of 20 000 yr with the subsurface transport over reactive multiphases (STORM) code. Time and spatial dependence of glass corrosion rate, secondary phase formation, pH, and radionuclide concentration were evaluated. The results show low release rates overall for the LAW glasses such that performance objectives for the site will be met by a factor of 20 or more. Parameterization of the computer model was accomplished by combining direct laboratory measurements, literature data (principally thermodynamic data), and parameter estimation methods

Broken home or drug using peers : "Significant relations"?

NARCIS (Netherlands)

Quensel, S; McArdle, P; Brinkley, A; Wiegersma, A; Blom, M; Fitzgerald, M; Johnson, R; Kolte, B; Michels, [No Value; Pierolini, A; Pos, R; Stoeckel, [No Value

2002-01-01

This study reports the results of a comparative survey with representative samples of 3,386 school attending youths, most of whom were 15 years of age and residing in five European cities. We found significant but low correlations between the type of family structure (intact family, model family,

Marine hydrogeology: recent accomplishments and future opportunities

Science.gov (United States)

Fisher, A. T.

2005-03-01

Marine hydrogeology is a broad-ranging scientific discipline involving the exploration of fluid-rock interactions below the seafloor. Studies have been conducted at seafloor spreading centers, mid-plate locations, and in plate- and continental-margin environments. Although many seafloor locations are remote, there are aspects of marine systems that make them uniquely suited for hydrologic analysis. Newly developed tools and techniques, and the establishment of several multidisciplinary programs for oceanographic exploration, have helped to push marine hydrogeology forward over the last several decades. Most marine hydrogeologic work has focused on measurement or estimation of hydrogeologic properties within the shallow subsurface, but additional work has emphasized measurements of local and global fluxes, fluid source and sink terms, and quantitative links between hydrogeologic, chemical, tectonic, biological, and geophysical processes. In addition to summarizing selected results from a small number of case studies, this paper includes a description of several new experiments and programs that will provide outstanding opportunities to address fundamental hydrogeologic questions within the seafloor during the next 20-30 years. L'hydrogéologie marine est une large discipline scientifique impliquant l' exploration des interactions entre les fluides et les roches sous les fonds marins. Des études ont été menées dans les différents environnements sous-marins (zone abyssale, plaque océanique, marges continentales). Bien que de nombreux fonds marins soient connus, il existe des aspects des systèmes marins qui les rendent inadaptés à l'analyse hydrologique. De nouveaux outils et techniques, et la mise en oeuvre de nombreux programmes multidisciplinaires d'exploration océanographique, ont aidé à pousser en avant l'hydrogéologie marine ces dix dernières années. La plus part des études hydrogéologiques se sont concentrées jusqu'à présent sur la mesure ou

SIGNIFICANT PROGRESS IN THE DEPLOYMENT OF NEW TECHNOLOGIES FOR THE RETRIEVAL OF HANFORD RADIOACTIVE WASTE STORAGE TANKS

International Nuclear Information System (INIS)

RAYMOND RE; DODD RA; CARPENTER KE; STURGES MH

2008-01-01

Significant enhancements in the development and deployment of new technologies for removing waste from storage tanks at the Hanford Site have resulted in accelerated progress and reduced costs for tank cleanup. CH2M HILL Hanford Group, Inc. is the U.S. Department of Energy, Office of River Protection's prime contractor responsible for safely storing and retrieving approximately 53 million gallons of highly-radioactive and hazardous waste stored in 177 underground tanks. The waste is stored in 149 older single-shell tanks (SST) and 28 newer double-shell tanks (DST) that are grouped in 18 so-called farms near the center of the Hanford Site, located in southeastern Washington State. Tank contents include materials from years of World-War II and post-war weapons production, which account for 60 percent by volume of the nation's high-level radioactive waste. A key strategy for improved cleanup is the development and deployment of innovative technologies, which enhance worker safety, resolve technical challenges, streamline retrieval processes, and cut project costs and durations. During the past seven years of tank cleanout projects we have encountered conditions and waste chemistry that defy conventional approaches, requiring a variety of new tools and techniques. Through the deployment of advanced technology and the creative application of resources, we are finding ways to accomplish the retrieval process safely, swiftly, and economically. To date, retrieval operations have been completed in seven tanks, including a record six tanks in a two-year period. Retrieval operations are in progress for another three tanks. This paper describes the following tank cleanup technologies deployed at Hanford in the past few years: Modified waste sluicing, High pressure water lance, Mobile retrieval tools, Saltcake dissolution, Vacuum retrieval, Sparging of wastes, Selective dissolution for waste treatment, Oxalic acid dissolution, High-pressure water mixers, Variable height pumps

Laser fusion study. Final report, volume I, study results

International Nuclear Information System (INIS)

1975-06-01

The primary goal of this study was to devise, evaluate, and conceptually design a complete, end-to-end, alignment system capable of handling 30 to 32 Shiva amplifier chains to specified accuracies in space and time. A secondary goal was to accomplish the primary goal with an acceptably low development and procurement cost and with an acceptably high day-after-day performance reliability. This report presents such a system: it is comprised of sensors, actuating mechanisms, controls, and displays that perform well within the current art-state. (U.S.)

Identification of clinically significant drug-drug interactions in cardiac ...

African Journals Online (AJOL)

Purpose: To identify clinically significant potential drug-drug interactions in cardiac intensive care units of two tertiary care ... hypertension, hyperlipidemia, diabetes or other diseases .... May result in digoxin toxicity (nausea, vomiting, cardiac.

Significance of postoperative irradiation for breast cancer

International Nuclear Information System (INIS)

Murai, Nobuko; Ogami, Koji; Nishikawa, Kiyoshi; Koga, Kenji; Waki, Norio; Higashi, Hidefumi; Hayashi, Asami; Shibata, Koichiro; Watanabe, Katsuji

1986-01-01

From 1978 through 1983, 27 patients were treated with surgery followed by irradiation (irradiated group) and 29 with surery alone (non-irradiated group). In the irradiated group, 10 had stage II and 17 stage III; in the non-irradiated group, 25 had stage II and 4 stage III. The most common histology was medullary tubular carcinoma (MTC). There was no significant difference in survivals at 3 years and 5 years between the groups. Similarly, no significant difference was seen among stage II patients. Patients with MTC tended to have worse survivals in the irradiated group than in the non-irradiated group, with no statistically significant difference. Among stage II patients, no major differences in local recurrence were seen between the groups; the incidence of distant metastases tended to be high in the irradiated group. The incidence of both local recurrence and distant metastases for stage III patients showed a tendency to be higher in the irradiated group than in the non-irradiated group. The results indicated no apparent benifit of postoperative irradiation for breast cancer. A randomized clinical trial is needed for the evaluation of postoperative irradiation for breast cancer. (Namekawa, K.)

Significance and radioimmunoassay of gastric inhibitory polypeptide

International Nuclear Information System (INIS)

Zheng Ping; Zeng Minde; Yuan Jimin

1995-01-01

We have established the GIP Radioimmunoassay which has high sensitivity and specificity by labelling with iodogen and purified with HPLC. Using this method, the plasma GIP level was measured in 64 cases of which there are 10 normal individuals, 25 cases of diabetes and 29 cases of liver cirrhosis . The results showed that the plasma GIP level was significantly increased in patients with liver cirrhosis and correlated to degree of glucose tolerance damage

Late Quaternary stratigraphy of the La Janda Basin (SW Spain) - first results and palaeoenvironmental significance

Science.gov (United States)

Höbig, Nicole; Santisteban, Juan; Mediavilla, Rosa; May, Simon Matthias; Klasen, Nicole; Brückner, Helmut; van't Hoff, Jasmijn; Reicherter, Klaus

2017-04-01

The La Janda basin in southern Spain is a near-shore geo-bio-archive comprising a variable Quaternary depositional history, with shallow marine, lacustrine, palustrine, and terrestrial strata. In the 1930s the lake was drained and is serving now as a huge agricultural area. The 33 m-core recovered in fall 2016 along with several shallower drill cores up to c. 15 m, reveals insights into a unique mixed terrestrial palaeo-environmental archive in Andalucia influenced by the Atlantic Ocean and hence the North Atlantic Oscillation (NAO) within the Gulf of Cádiz. The basin's evolution was influenced both by the postglacial marine transgression and by an active tectonic fault controlling most of the accommodation space by causing subsidence. Our long core was accompanied by further corings along an E-W striking transect in order to reveal also the relation of the influence of tectonic activity with sedimentary sequences. Multi-Sensor Core Logging has been completed. Results of sedimentological, geochemical and micropalaeontological analyses will be presented in the frame of the climate variations during the Late Pleistocene and the Holocene, along with a preliminary age-depth model based on radiocarbon (AMS-14C) and optical stimulated luminescence (OSL) dating techniques. Our investigations ultimately aim at providing valuable information on major Late Pleistocene to Holocene climatic and palaeo-environmental fluctuations in the southernmost part of the Iberian Peninsula.

PROMPT Ia SUPERNOVAE ARE SIGNIFICANTLY DELAYED

International Nuclear Information System (INIS)

Raskin, Cody; Scannapieco, Evan; Rhoads, James; Della Valle, Massimo

2009-01-01

The time delay between the formation of a population of stars and the onset of type Ia supernovae (SNe Ia) sets important limits on the masses and nature of SN Ia progenitors. Here, we use a new observational technique to measure this time delay by comparing the spatial distributions of SNe Ia to their local environments. Previous work attempted such analyses encompassing the entire host of each SN Ia, yielding inconclusive results. Our approach confines the analysis only to the relevant portions of the hosts, allowing us to show that even so-called prompt SNe Ia that trace star formation on cosmic timescales exhibit a significant delay time of 200-500 million years. This implies that either the majority of Ia companion stars have main-sequence masses less than 3 M sun , or that most SNe Ia arise from double white dwarf binaries. Our results are also consistent with a SNe Ia rate that traces the white dwarf formation rate, scaled by a fixed efficiency factor.

Results of 7th regular inspection of No.1 plant in Oi Power Station, Kansai Electric Power Co., Inc

International Nuclear Information System (INIS)

1989-01-01

The 7th regular inspection of No.1 plant in Oi Power Station was carried out from December 25, 1987 to July 15, 1988. The parallel operation was resumed on June 23, 1988, 182 days after the start of the inspection. The facilities to be inspected were the reactor proper, reactor cooling system, measurement and control system, fuel facilities, radiation control facilities, waste facilities, reactor containment installation and emergency power generation system. On these facilities to be inspected, the appearance, disassembling, leak, function, performance and other inspections were carried out, and as the results, a part of the fitting of a water chamber partition cover for a steam generator broke off, significant signals were observed in 936 heating tubes of steam generators, 72 bolts for fixing the blade of a primary coolant pump were damaged, and leak was found in two fuel assemblies. The works related to this regular inspection were accomplished within the range of allowable radiation dose based on the relevant laws. The main reconstruction works carried out during the period of this regular inspection were the use of the fuel containing gadolinia, the removal of a thermometer bypass piping and the repair of defective steam generator tubes. (K.I.)

Kinematics effectively delineate accomplished users of endovascular robotics with a physical training model.

Science.gov (United States)

Duran, Cassidy; Estrada, Sean; O'Malley, Marcia; Lumsden, Alan B; Bismuth, Jean

2015-02-01

Endovascular robotics systems, now approved for clinical use in the United States and Europe, are seeing rapid growth in interest. Determining who has sufficient expertise for safe and effective clinical use remains elusive. Our aim was to analyze performance on a robotic platform to determine what defines an expert user. During three sessions, 21 subjects with a range of endovascular expertise and endovascular robotic experience (novices 20 hours) performed four tasks on a training model. All participants completed a 2-hour training session on the robot by a certified instructor. Completion times, global rating scores, and motion metrics were collected to assess performance. Electromagnetic tracking was used to capture and to analyze catheter tip motion. Motion analysis was based on derivations of speed and position including spectral arc length and total number of submovements (inversely proportional to proficiency of motion) and duration of submovements (directly proportional to proficiency). Ninety-eight percent of competent subjects successfully completed the tasks within the given time, whereas 91% of noncompetent subjects were successful. There was no significant difference in completion times between competent and noncompetent users except for the posterior branch (151 s:105 s; P = .01). The competent users had more efficient motion as evidenced by statistically significant differences in the metrics of motion analysis. Users with >20 hours of experience performed significantly better than those newer to the system, independent of prior endovascular experience. This study demonstrates that motion-based metrics can differentiate novice from trained users of flexible robotics systems for basic endovascular tasks. Efficiency of catheter movement, consistency of performance, and learning curves may help identify users who are sufficiently trained for safe clinical use of the system. This work will help identify the learning curve and specific movements that

AREVA - 2012 annual results: significant turnaround in performance one year after launching the Action 2016 plan

International Nuclear Information System (INIS)

Duperray, Julien; Berezowskyj, Katherine; Kempkes, Vincent; Rosso, Jerome; Thebault, Alexandre; Scorbiac, Marie de; Repaire, Philippine du

2013-01-01

One year after launching Areva's Action 2016 strategic plan, the first results are in. AREVA is ahead of schedule in executing its recovery plan. While pursuing its efforts in the management of a few difficult projects (such as OL3), Areva group was able to return to a virtuous performance cycle rooted in strong growth in nuclear order intake and good progress on its cost reduction program. Commercially, despite the difficult economic environment, AREVA was able to capitalize on its leadership in the installed base and on its long-term partnerships with strategic customers, beginning with EDF, with which AREVA renewed a confident and constructive working relationship. Areva has secured 80% of its objective of one billion euros of savings by the end of 2015 to improve its competitiveness. The group also continued efforts to optimize working capital requirement and control the capital expenditure trajectory. Together, these results enabled AREVA to exceed the objectives set for 2012 for two key indicators of its strategic plan: EBITDA and free operating cash flow. Nearly 60% of the 2.1 billion euros devoted to capital expenditures for future growth in 2012 were funded by operations, a quasi-doubled share compared to 2011. Areva's floor target for asset disposals was achieved one year ahead of schedule, also helping the Group to control its net debt, which remained below 4 billion euros. In 2013, Areva is continuing to implement the Action 2016 plan to keep its turnaround on track. In summary: - Backlog renewed over the year 2012 to euro 45.4 bn thanks to the increase in nuclear order intake; - Sales revenue growth: euro 9.342 bn (+5.3% vs. 2011), led by nuclear and renewables operations; - Very sharp upturn in EBITDA: euro 1.007 bn (+euro 586 m vs. 2011) - Very net improvement in free operating cash flow: -euro 854 m (+euro 512 m vs. 2011); - Back to positive reported operating income: euro 118 m (+euro 1.984 bn vs. 2011); - 2012-2013 floor target for asset disposals

Determining Semantically Related Significant Genes.

Science.gov (United States)

Taha, Kamal

2014-01-01

GO relation embodies some aspects of existence dependency. If GO term xis existence-dependent on GO term y, the presence of y implies the presence of x. Therefore, the genes annotated with the function of the GO term y are usually functionally and semantically related to the genes annotated with the function of the GO term x. A large number of gene set enrichment analysis methods have been developed in recent years for analyzing gene sets enrichment. However, most of these methods overlook the structural dependencies between GO terms in GO graph by not considering the concept of existence dependency. We propose in this paper a biological search engine called RSGSearch that identifies enriched sets of genes annotated with different functions using the concept of existence dependency. We observe that GO term xcannot be existence-dependent on GO term y, if x- and y- have the same specificity (biological characteristics). After encoding into a numeric format the contributions of GO terms annotating target genes to the semantics of their lowest common ancestors (LCAs), RSGSearch uses microarray experiment to identify the most significant LCA that annotates the result genes. We evaluated RSGSearch experimentally and compared it with five gene set enrichment systems. Results showed marked improvement.

Impact significance determination-Back to basics

International Nuclear Information System (INIS)

Lawrence, David P.

2007-01-01

Impact significance determination is widely recognized as a vital and critical EIA activity. But impact significance related concepts are poorly understood. And the quality of approaches for impact significance determination in EIA practice remains highly variable. This article seeks to help establish a sound and practical conceptual foundation for formulating and evaluating impact significance determination approaches. It addresses the nature (what is impact significance?), the core characteristics (what are the major properties of significance determination?), the rationale (why are impact significance determinations necessary?), the procedural and substantive objectives (what do impact significance determinations seek to achieve?), and the process for making impact significance judgments (how is impact significance determination conducted?). By identifying fundamental attributes and key distinctions associated with impact significance determinations, a basis is provided for designing and evaluating impact significance determination procedures at both the regulatory and applied levels

Significance testing in ridge regression for genetic data

Directory of Open Access Journals (Sweden)

De Iorio Maria

2011-09-01

Full Text Available Abstract Background Technological developments have increased the feasibility of large scale genetic association studies. Densely typed genetic markers are obtained using SNP arrays, next-generation sequencing technologies and imputation. However, SNPs typed using these methods can be highly correlated due to linkage disequilibrium among them, and standard multiple regression techniques fail with these data sets due to their high dimensionality and correlation structure. There has been increasing interest in using penalised regression in the analysis of high dimensional data. Ridge regression is one such penalised regression technique which does not perform variable selection, instead estimating a regression coefficient for each predictor variable. It is therefore desirable to obtain an estimate of the significance of each ridge regression coefficient. Results We develop and evaluate a test of significance for ridge regression coefficients. Using simulation studies, we demonstrate that the performance of the test is comparable to that of a permutation test, with the advantage of a much-reduced computational cost. We introduce the p-value trace, a plot of the negative logarithm of the p-values of ridge regression coefficients with increasing shrinkage parameter, which enables the visualisation of the change in p-value of the regression coefficients with increasing penalisation. We apply the proposed method to a lung cancer case-control data set from EPIC, the European Prospective Investigation into Cancer and Nutrition. Conclusions The proposed test is a useful alternative to a permutation test for the estimation of the significance of ridge regression coefficients, at a much-reduced computational cost. The p-value trace is an informative graphical tool for evaluating the results of a test of significance of ridge regression coefficients as the shrinkage parameter increases, and the proposed test makes its production computationally feasible.

Cross wavelet analysis: significance testing and pitfalls

Directory of Open Access Journals (Sweden)

D. Maraun

2004-01-01

Full Text Available In this paper, we present a detailed evaluation of cross wavelet analysis of bivariate time series. We develop a statistical test for zero wavelet coherency based on Monte Carlo simulations. If at least one of the two processes considered is Gaussian white noise, an approximative formula for the critical value can be utilized. In a second part, typical pitfalls of wavelet cross spectra and wavelet coherency are discussed. The wavelet cross spectrum appears to be not suitable for significance testing the interrelation between two processes. Instead, one should rather apply wavelet coherency. Furthermore we investigate problems due to multiple testing. Based on these results, we show that coherency between ENSO and NAO is an artefact for most of the time from 1900 to 1995. However, during a distinct period from around 1920 to 1940, significant coherency between the two phenomena occurs.

Sixteen-Day Bedrest Significantly Increases Plasma Colloid Osmotic Pressure

Science.gov (United States)

Hargens, Alan R.; Hsieh, S. T.; Murthy, G.; Ballard, R. E.; Convertino, V. A.; Wade, Charles E. (Technical Monitor)

1994-01-01

Upon exposure to microgravity, astronauts lose up to 10% of their total plasma volume, which may contribute to orthostatic intolerance after space flight. Because plasma colloid osmotic pressure (COP) is a primary factor maintaining plasma volume, our objective was to measure time course changes in COP during microgravity simulated by 6 deg. head-down tilt (HDT). Seven healthy male subjects (30-55 years of age) were placed in HDT for 16 days. For the purpose of another study, three of the seven subjects were chosen to exercise on a cycle ergometer on day 16. Blood samples were drawn immediately before bedrest on day 14 of bedrest, 18-24 hours following exercise while all subjects were still in HDT and 1 hour following bedrest termination. Plasma COP was measured in all 20 microliter EDTA-treated samples using an osmometer fitted with a PM 30 membrane. Data were analyzed with paired and unpaired t-tests. Plasma COP on day 14 of bedrest (29.9 +/- 0.69 mmHg) was significantly higher (p less than 0.005) than the control, pre-bedrest value (23.1 +/- 0.76 mmHg). At one hour of upright recovery after HDT, plasma COP remained significantly elevated (exercise: 26.9 +/- 0.87 mmHg; no exercise: 26.3 +/- 0.85 mmHg). Additionally, exercise had no significant effect on plasma COP 18-24 hours following exercise (exercise: 27.8 +/- 1.09 mmHg; no exercise: 27.1 +/- 0.78 mmHg). Our results demonstrate that plasma COP increases significantly with microgravity simulated by HDT. However, preliminary results indicate exercise during HDT does not significantly affect plasma COP.

The significance test controversy revisited the fiducial Bayesian alternative

CERN Document Server

Lecoutre, Bruno

2014-01-01

The purpose of this book is not only to revisit the “significance test controversy,”but also to provide a conceptually sounder alternative. As such, it presents a Bayesian framework for a new approach to analyzing and interpreting experimental data. It also prepares students and researchers for reporting on experimental results. Normative aspects: The main views of statistical tests are revisited and the philosophies of Fisher, Neyman-Pearson and Jeffrey are discussed in detail. Descriptive aspects: The misuses of Null Hypothesis Significance Tests are reconsidered in light of Jeffreys’ Bayesian conceptions concerning the role of statistical inference in experimental investigations. Prescriptive aspects: The current effect size and confidence interval reporting practices are presented and seriously questioned. Methodological aspects are carefully discussed and fiducial Bayesian methods are proposed as a more suitable alternative for reporting on experimental results. In closing, basic routine procedures...

Five-year results from a prospective multicentre study of percutaneous pulmonary valve implantation demonstrate sustained removal of significant pulmonary regurgitation, improved right ventricular outflow tract obstruction and improved quality of life

DEFF Research Database (Denmark)

Hager, Alfred; Schubert, Stephan; Ewert, Peter

2017-01-01

. The EQ-5D quality of life utility index and visual analogue scale scores were both significantly improved six months post PPVI and remained so at five years. CONCLUSIONS: Five-year results following PPVI demonstrate resolved moderate or severe pulmonary regurgitation, improved right ventricular outflow...

A shift from significance test to hypothesis test through power analysis in medical research.

Science.gov (United States)

Singh, G

2006-01-01

Medical research literature until recently, exhibited substantial dominance of the Fisher's significance test approach of statistical inference concentrating more on probability of type I error over Neyman-Pearson's hypothesis test considering both probability of type I and II error. Fisher's approach dichotomises results into significant or not significant results with a P value. The Neyman-Pearson's approach talks of acceptance or rejection of null hypothesis. Based on the same theory these two approaches deal with same objective and conclude in their own way. The advancement in computing techniques and availability of statistical software have resulted in increasing application of power calculations in medical research and thereby reporting the result of significance tests in the light of power of the test also. Significance test approach, when it incorporates power analysis contains the essence of hypothesis test approach. It may be safely argued that rising application of power analysis in medical research may have initiated a shift from Fisher's significance test to Neyman-Pearson's hypothesis test procedure.

Understanding the Sampling Distribution and Its Use in Testing Statistical Significance.

Science.gov (United States)

Breunig, Nancy A.

Despite the increasing criticism of statistical significance testing by researchers, particularly in the publication of the 1994 American Psychological Association's style manual, statistical significance test results are still popular in journal articles. For this reason, it remains important to understand the logic of inferential statistics. A…

Real Time Precise Point Positioning: Preliminary Results for the Brazilian Region

Science.gov (United States)

Marques, Haroldo; Monico, João.; Hirokazu Shimabukuro, Milton; Aquino, Marcio

2010-05-01

this paper our proposition is to present the mathematical models implemented in the PPP_RT software and some proposal to accomplish the PPP in real time as for example using tropospheric model from Brazilian Numerical Weather Forecast Model (BNWFM) and estimating the ionosphere using stochastic process. GPS data sample from the Brazilian region was processed using the PPP_RT software considering periods under low and high ionospheric activities and the results estimating the ionosphere were compared with the ion-free combination. The PPP results also were analyzed considering the strategy of the troposphere estimation, Hopfield model or using the BNWFM. For the troposphere case, the values from BNWFM can reach similar results when estimating the troposphere. For the ionosphere case, the results have shown that ionosphere estimation can improve the time convergence of the PPP processing what is very important for PPP in real time.

Exploring the relationships among personality traits, burnout dimensions and stigma in a sample of mental health professionals.

Science.gov (United States)

Zaninotto, Leonardo; Rossi, Genny; Danieli, Andrea; Frasson, Alberto; Meneghetti, Leonardo; Zordan, Maria; Tito, Paolo; Salvetti, Beatrice; Conca, Andreas; Ferranti, Roberta; Salcuni, Silvia; Solmi, Marco

2018-04-07

A sample of mental health professionals (n = 215) from six Community Mental Health Services was examined using a short version of the Attribution Questionnaire-27, the Maslach Burnout Inventory and the Ten Items Personality Inventory to detect possible associations among stigma, burnout dimensions and personality traits. The role of demographic and professional variables was also explored. Perception of workplace safety resulted to significantly affect attitudes toward patients. The concern about being assaulted and a low level of Personal Accomplishment were both related to avoidant attitudes, while the presence of procedures for managing the violent patient was associated with a higher level of Personal Accomplishment. Conversely, Emotional Stability and Openness to new experiences were inversely correlated with burnout dimensions and avoidant attitudes, respectively. Overall, our study supports the view of a significant association among some dimensions of stigma, burnout and personality factors. In particular, avoidant attitudes toward patients may be influenced by Personal Accomplishment and Openness to new experiences. Copyright © 2018 Elsevier B.V. All rights reserved.

Genome-wide identification of significant aberrations in cancer genome

Directory of Open Access Journals (Sweden)

Yuan Xiguo

2012-07-01

Full Text Available Abstract Background Somatic Copy Number Alterations (CNAs in human genomes are present in almost all human cancers. Systematic efforts to characterize such structural variants must effectively distinguish significant consensus events from random background aberrations. Here we introduce Significant Aberration in Cancer (SAIC, a new method for characterizing and assessing the statistical significance of recurrent CNA units. Three main features of SAIC include: (1 exploiting the intrinsic correlation among consecutive probes to assign a score to each CNA unit instead of single probes; (2 performing permutations on CNA units that preserve correlations inherent in the copy number data; and (3 iteratively detecting Significant Copy Number Aberrations (SCAs and estimating an unbiased null distribution by applying an SCA-exclusive permutation scheme. Results We test and compare the performance of SAIC against four peer methods (GISTIC, STAC, KC-SMART, CMDS on a large number of simulation datasets. Experimental results show that SAIC outperforms peer methods in terms of larger area under the Receiver Operating Characteristics curve and increased detection power. We then apply SAIC to analyze structural genomic aberrations acquired in four real cancer genome-wide copy number data sets (ovarian cancer, metastatic prostate cancer, lung adenocarcinoma, glioblastoma. When compared with previously reported results, SAIC successfully identifies most SCAs known to be of biological significance and associated with oncogenes (e.g., KRAS, CCNE1, and MYC or tumor suppressor genes (e.g., CDKN2A/B. Furthermore, SAIC identifies a number of novel SCAs in these copy number data that encompass tumor related genes and may warrant further studies. Conclusions Supported by a well-grounded theoretical framework, SAIC has been developed and used to identify SCAs in various cancer copy number data sets, providing useful information to study the landscape of cancer genomes

Sandia Technology engineering and science accomplishments

Energy Technology Data Exchange (ETDEWEB)

1994-02-01

This report briefly discusses the following research being conducted at Sandia Laboratories: Advanced Manufacturing -- Sandia technology helps keep US industry in the lead; Microelectronics-Sandia`s unique facilities transform research advances into manufacturable products; Energy -- Sandia`s energy programs focus on strengthening industrial growth and political decisionmaking; Environment -- Sandia is a leader in environmentally conscious manufacturing and hazardous waste reduction; Health Care -- New biomedical technologies help reduce cost and improve quality of health care; Information & Computation -- Sandia aims to help make the information age a reality; Transportation -- This new initiative at the Labs will help improve transportation, safety,l efficiency, and economy; Nonproliferation -- Dismantlement and arms control are major areas of emphasis at Sandia; and Awards and Patents -- Talented, dedicated employees are the backbone of Sandia`s success.

LS1 Report: first missions accomplished

CERN Multimedia

CERN Bulletin

2013-01-01

Things are going well in all the Laboratory’s accelerators. For the SMACC project at the LHC (see here), work on the machine’s outer W bellows is well advanced with over half now opened up. To date we have completed 15% of the project and all the magnet and superconducting circuit consolidation activities are now being submitted to a quality audit by external experts from laboratories all over the world.   Picture 1: one of the Point 7 access galleries after enlargment. Magnets are being replaced according to the schedule and the last of them should be in place before mid-August. The Radiation to Electronics (R2E) project to relocate the electronics is progressing particularly well and is one week ahead of schedule. At Point 7, the civil-engineering work to widen one of the access galleries is almost complete (see picture 1). At Point 5, drilling to allow the passage of the last of the 14 m-long sleeves, 40 cm in diameter, has been successfully completed. Unfortunately ...

Accomplishment Report for Fiscal Year 2001

National Research Council Canada - National Science Library

2002-01-01

SSC San Diego C4I Programs Office Philadelphia is responsible for a program of development, in-service engineering, procurement, installation support, configuration control, and integrated logistics...

Aims and accomplishments of surface theory

International Nuclear Information System (INIS)

Feibelman, P.J.

1979-01-01

The goals of surface science include the understanding of surface structure, transport and chemistry. However, present activities are mainly focussed on the most basic problem, viz., what are the constituents of a given surface and where are they located. Theorists are approaching this surface characterization problem from two sides. To make better use of the data available from the many experimental surface probes, an understanding of the force laws which govern the motion of probe-particles near surfaces is being developed, and the relation between the excitation and ground state spectra of a solid are being studied. In order to develop a predictive capability regarding surface structure, a variety of intrinsic surface properties are being studied, including the nature of bonds at transition metal surfaces, the meaning of bond locality in extended systems, and the electronic factors underlying the forces which govern surface geometry. These studies often raise technical issues such as the validity of using local exchange-correlation potentials and the applicability of cluster calculations to the analysis of extended surface situations, which, however, should not obscure the main thrust of current work - empirical and predictive surface structure determination. These points are illustrated with examples from recent research and ways in which experimental surface work might assist theoretical efforts are indicated

TRISTAN I: techniques, capabilities, and accomplishments

International Nuclear Information System (INIS)

Talbert, W.L. Jr.

1977-01-01

Following a brief description of the TRISTAN facility, the techniques developed for on-line nuclear spectroscopy of short-lived fission products, the studies possible, and the activities studied are presented. All journal publications relating to the development of the facility and the studies carried out using it are referenced, and co-workers identified

Modeling and simulation goals and accomplishments

International Nuclear Information System (INIS)

Turinsky, P.

2013-01-01

The CASL (Consortium for Advanced Simulation of Light Water Reactors) mission is to develop and apply the Virtual Reactor simulator (VERA) to optimise nuclear power in terms of capital and operating costs, of nuclear waste production and of nuclear safety. An efficient and reliable virtual reactor simulator relies on 3-dimensional calculations, accurate physics models and code coupling. Advances in computer hardware, along with comparable advances in numerical solvers make the VERA project achievable. This series of slides details the VERA project and presents the specificities and performance of the codes involved in the project and ends by listing the computing needs

LAMPF: its origins, history, and accomplishments

International Nuclear Information System (INIS)

Rosen, L.

1985-01-01

The main vehicle for bringing the pion to bear on a vast array of problems, has been the meson factories. Today there exist such facilities in Switzerland (SIN), in Canada (TRIUMF), and in the USA (LAMPF). A fourth is just now being completed in the Soviet Union. They are enormous enterprises - the current replacement value of LMPF is $350 million, not including the part devoted to national security problems. But they accommodate hundreds of scientists from around the world and by so doing generate political as well as intellectual and economic capital. Proton facilities, together with heavy-ion accelerators and electron facilities, form a triad on which stands the present edifice of experimental nuclear science. Each leg of this triad is dependent, to a greater or lesser extent, on the other two. However, in terms of versatility, the size of the community it serves, and the relatively short-term application of the knowledge base and people base for which nuclear science is responsible, the meson factory part of the above triad is by no means the least important component. I discuss this component from the standpoint of the facility I know best, namely LAMPF. 33 refs., 36 figs

Significance of autobiographical episodes and spacing effects in incidental memory.

Science.gov (United States)

Toyota, Hiroshi

2013-10-01

Participants were presented with target words on two occasions, and were asked each time to generate a memory of a past episode associated with the targets. Participants were also instructed to rate the importance (significance elaboration) or pleasantness of the pisode (pleasantness elaboration) in an orienting task, followed by an unexpect d recall test. Significance elaboration led to better recall than pleasantness elaboration, but only in the spaced presentation. The spaced presentation led to better tree recall than massed presentation with significance elaboration, but the difference between the two types of presentation was not observed with pleasantness elaboration. These results suggest that the significance of an episode is more critical than the pleasantness of an episode in determining the effectiveness of autobiographical elaboration in facilitating recall.

Human Factors Engineering and Ergonomics Analysis for the Canister Storage Building (CSB) Results and Findings

International Nuclear Information System (INIS)

GARVIN, L.J.

1999-01-01

The purpose for this supplemental report is to follow-up and update the information in SNF-3907, Human Factors Engineering (HFE) Analysis: Results and Findings. This supplemental report responds to applicable U.S. Department of Energy Safety Analysis Report review team comments and questions. This Human Factors Engineering and Ergonomics (HFE/Erg) analysis was conducted from April 1999 to July 1999; SNF-3907 was based on analyses accomplished in October 1998. The HFE/Erg findings presented in this report and SNF-3907, along with the results of HNF-3553, Spent Nuclear Fuel Project, Final Safety Analysis Report. Annex A, ''Canister Storage Building Final Safety Analysis Report,'' Chapter A3.0, ''Hazards and Accidents Analyses,'' provide the technical basis for preparing or updating HNF-3553, Annex A, Chapter A13.0, ''Human Factors Engineering.'' The findings presented in this report allow the HNF-3553 Chapter 13.0, ''Human Factors,'' to respond fully to the HFE requirements established in DOE Order 5480.23, Nuclear Safety Analysis Reports

Human Factors Engineering and Ergonomics Analysis for the Canister Storage Building (CSB): Results and Findings

International Nuclear Information System (INIS)

GARVIN, L.J.

1999-01-01

The purpose for this supplemental report is to follow-up and update the information in SNF-3907, Human Factors Engineering (HFE) Analysis: Results and Findings. This supplemental report responds to applicable U.S. Department of Energy Safety Analysis Report review team comments and questions. This Human Factors Engineering and Ergonomics (HFE/Erg) analysis was conducted from April 1999 to July 1999; SNF-3907 was based on analyses accomplished in October 1998. The HFE/Erg findings presented in this report and SNF-3907, along with the results of HNF-3553, Spent Nuclear Fuel Project, Final Safety Analysis Report, Annex A, ''Canister Storage Building Final Safety Analysis Report,'' Chapter A3.0, ''Hazards and Accidents Analyses,'' provide the technical basis for preparing or updating HNF-3553. Annex A, Chaptex A13.0, ''Human Factors Engineering.'' The findings presented in this report allow the HNF-3553 Chapter 13.0, ''Human Factors,'' to respond fully to the HFE requirements established in DOE Order 5480.23, Nuclear Safety Analysis Reports

Clinical Significance of Resistin Expression in Osteoarthritis: A Meta-Analysis

Directory of Open Access Journals (Sweden)

Xiao-Chuan Li

2014-01-01

Full Text Available Background. The objective of this study was to conduct a systematic review of literature evaluating human resistin expression as a diagnostic factor in osteoarthritis development and to quantify the overall diagnostic effect. Method. Relevant studies were identified and evaluated for quality through multiple search strategies. Studies analyzing resistin expression in the development of OA were eligible for inclusion. Data from eligible studies were extracted and included into the meta-analysis using a random-effects model. Results. Four case-control studies consisting of a total of 375 OA patients and 214 controls as well as three sex-stratified analyses composed of 53 males and 104 females were incorporated into our meta-analysis. Our results revealed that resistin levels were significantly higher in male OA subjects and OA patients overall. Country-stratified analysis yielded significantly different estimates in resistin levels between male OA subjects and female OA subjects in the Canadian subgroup but not among the French and USA subgroups. Based on the resistin levels in OA cases and controls, resistin levels were heightened in OA patients in the Dutch population. Conclusion. These results support the hypothesis that high expression of resistin represents a significant and reproducible marker of poor progression in OA patients, especially in males.

Low-dose vaporized cannabis significantly improves neuropathic pain.

Science.gov (United States)

Wilsey, Barth; Marcotte, Thomas; Deutsch, Reena; Gouaux, Ben; Sakai, Staci; Donaghe, Haylee

2013-02-01

We conducted a double-blind, placebo-controlled, crossover study evaluating the analgesic efficacy of vaporized cannabis in subjects, the majority of whom were experiencing neuropathic pain despite traditional treatment. Thirty-nine patients with central and peripheral neuropathic pain underwent a standardized procedure for inhaling medium-dose (3.53%), low-dose (1.29%), or placebo cannabis with the primary outcome being visual analog scale pain intensity. Psychoactive side effects and neuropsychological performance were also evaluated. Mixed-effects regression models demonstrated an analgesic response to vaporized cannabis. There was no significant difference between the 2 active dose groups' results (P > .7). The number needed to treat (NNT) to achieve 30% pain reduction was 3.2 for placebo versus low-dose, 2.9 for placebo versus medium-dose, and 25 for medium- versus low-dose. As these NNTs are comparable to those of traditional neuropathic pain medications, cannabis has analgesic efficacy with the low dose being as effective a pain reliever as the medium dose. Psychoactive effects were minimal and well tolerated, and neuropsychological effects were of limited duration and readily reversible within 1 to 2 hours. Vaporized cannabis, even at low doses, may present an effective option for patients with treatment-resistant neuropathic pain. The analgesia obtained from a low dose of delta-9-tetrahydrocannabinol (1.29%) in patients, most of whom were experiencing neuropathic pain despite conventional treatments, is a clinically significant outcome. In general, the effect sizes on cognitive testing were consistent with this minimal dose. As a result, one might not anticipate a significant impact on daily functioning. Published by Elsevier Inc.

Could patients' coughing have communicative significance?

Science.gov (United States)

Bailey, Julia V

2008-01-01

Medical discourse positions patients with coughs and colds negatively, so consulting health services with 'minor' respiratory illness is therefore more accountable than for other medical problems. Patients face dilemmas since they must persuade doctors of the doctorability of their illness without being seen as hypochondriacal, and they risk losing face if doctors decide that there is nothing much wrong. It is known that the placement of non-lexical features of talk such as laughing or crying can have interactional meaning. Using a data set of video-recorded doctor-patient cough and cold consultations, this study explores whether patients' coughing could have communicative significance. The study is a qualitative analysis of 33 consultations drawing on a constructionist, sociolinguistic analytic approach. Coughing is co-ordinated with talk rather than occurring randomly. Coughing helps patients to demonstrate the doctorability of their symptoms and to legitimize their claims for medical attention. Coughing is also associated with resistance to 'no problem' diagnoses, resulting in changes in the trajectory of talk (for example, soliciting more explanation from doctors and/or re-negotiation of doctors' investigation or treatment plans). Coughing is undoubtedly a manifestation of respiratory illness, but also has communicative significance in consultations for coughs and colds.

Report of the evaluation by the Ad Hoc Review Committee on advance science research. Result evaluation, interim evaluation, in-advance evaluation in fiscal year 2003

International Nuclear Information System (INIS)

2003-11-01

The Research Evaluation Committee, which consisted of 13 members from outside of the Japan Atomic Energy Research Institute (JAERI), set up an Ad Hoc Review Committee on Advanced Science Research in accordance with the Fundamental Guideline for the Evaluation of Research and Development (R and D) at JAERI' and its subsidiary regulations in order to evaluate the accomplishments of the research completed in Fiscal Year 2002, the accomplishments of the research started in Fiscal Year 2001, and the adequacy of the programs of the research to be started in Fiscal Year 2004 at Advanced Science Research Center of JAERI. The Ad Hoc Review Committee consisted of nine specialists from outside of JAERI. The Ad Hoc Review Committee conducted its activities from May to July 2003. The evaluation was performed on the basis of the materials submitted in advance and of the oral presentations made at the Ad Hoc Review Committee meeting which was held on June 24, 2003, in line with the items, viewpoints, and criteria for the evaluation specified by the Research Evaluation Committee. The result of the evaluation by the Ad Hoc Review Committee was submitted to the Research Evaluation Committee, and was judged to be appropriate at its meeting held on August 4, 2003. This report describes the result of the evaluation by the Ad Hoc Review Committee on Advanced Science Research. (author)

Report of the evaluation by the Ad Hoc Review Committee on Advance Science Research. Result evaluation, interim evaluation, in-advance evaluation in fiscal year 2002

Energy Technology Data Exchange (ETDEWEB)

NONE

2002-11-01

The Research Evaluation Committee, which consisted of 13 members from outside of the Japan Atomic Energy Research Institute (JAERI), set up an Ad Hoc Review Committee on Advanced Science Research in accordance with the Fundamental Guideline for the Evaluation of Research and Development (R and D) at JAERI' and its subsidiary regulations in order to evaluate the accomplishments of the research completed in Fiscal Year 2001, the accomplishments of the research started in Fiscal Year 2000, and the adequacy of the programs of the research to be started in Fiscal Year 2003 at Advanced Science Research Center of JAERI. The Ad Hoc Review Committee consisted of eight specialists from outside of JAERI. The Ad Hoc Review Committee conducted its activities from May to July 2002. The evaluation was performed on the basis of the materials submitted in advance and of the oral presentations made at the Ad Hoc Review Committee meeting which was held on June 4, 2002, in line with the items, viewpoints, and criteria for the evaluation specified by the Research Evaluation Committee. The result of the evaluation by the Ad Hoc Review Committee was submitted to the Research Evaluation Committee, and was judged to be appropriate at its meeting held on August 5, 2002. This report describes the result of the evaluation by the Ad Hoc Review Committee on Advanced Science Research. (author)

Acute and Chronic Fetal Anemia as a Result of Fetomaternal Hemorrhage

Directory of Open Access Journals (Sweden)

Paul Singh

2014-01-01

Full Text Available Introduction. Fetomaternal hemorrhage represents a transfer of fetal blood to the maternal circulation. Although many etiologies have been described, most causes of fetomaternal hemorrhage remain unidentified. The differentiation between acute and chronic fetomaternal hemorrhage may be accomplished antenatally and may influence perinatal management. Case. A 36-year-old gravida 6 para 3 presented at 37 and 5/7 completed gestational weeks with ultrasound findings suggestive of chronic fetal anemia such as right ventricular enlargement, diminished cerebral vascular resistance, and elevated middle cerebral artery end-diastolic velocity. On the other hand, signs of acute fetal decompensation such as deterioration of the fetal heart tracing, diminished biophysical score, decreased cord pH, and increased cord base deficit were noted. Following delivery, the neonate’s initial hemoglobin was 4.0 g/dL and the maternal KB ratio was 0.015 indicative of a significant fetomaternal hemorrhage. Discussion. One should consider FMH as part of the differential diagnosis for fetal or immediate neonatal anemia. We describe a unique case of FMH that demonstrated both acute and chronic clinical features. It is our hope that this case will assist practitioners in differentiating acute FMH that may require emergent delivery from chronic FMH which may be able to be expectantly managed.

Acute and chronic fetal anemia as a result of fetomaternal hemorrhage.

Science.gov (United States)

Singh, Paul; Swanson, Tara

2014-01-01

Introduction. Fetomaternal hemorrhage represents a transfer of fetal blood to the maternal circulation. Although many etiologies have been described, most causes of fetomaternal hemorrhage remain unidentified. The differentiation between acute and chronic fetomaternal hemorrhage may be accomplished antenatally and may influence perinatal management. Case. A 36-year-old gravida 6 para 3 presented at 37 and 5/7 completed gestational weeks with ultrasound findings suggestive of chronic fetal anemia such as right ventricular enlargement, diminished cerebral vascular resistance, and elevated middle cerebral artery end-diastolic velocity. On the other hand, signs of acute fetal decompensation such as deterioration of the fetal heart tracing, diminished biophysical score, decreased cord pH, and increased cord base deficit were noted. Following delivery, the neonate's initial hemoglobin was 4.0 g/dL and the maternal KB ratio was 0.015 indicative of a significant fetomaternal hemorrhage. Discussion. One should consider FMH as part of the differential diagnosis for fetal or immediate neonatal anemia. We describe a unique case of FMH that demonstrated both acute and chronic clinical features. It is our hope that this case will assist practitioners in differentiating acute FMH that may require emergent delivery from chronic FMH which may be able to be expectantly managed.

Significant prolongation of segmental pancreatic allograft survival in two species

Energy Technology Data Exchange (ETDEWEB)

Du Toit, D.F.; Heydenrych, J.J.

1988-06-01

A study was conducted to assess the suppression of segmental pancreatic allograft rejection by cyclosporine (CSA) alone in baboons and dogs, and subtotal marrow irradiation (TL1) alone and TL 1 in combination with CSA in baboons. Total pancreatectomy in the dog and primate provided a reliable diabetic model, induced an absolute deficiency of insulin and was uniformly lethal if not treated. Continuous administration of CSA in baboons resulted in modest allograft survival. As in baboons, dogs receiving CSA 25 mg/kg/d rendered moderate graft prolongation but a dose of 40 mg/kg/d resulted in significant graft survival (greater than 100 days) in 5 of 8 allograft recipients. Irradiation alone resulted in minimal baboon pancreatic allograft survival of 20 baboons receiving TL1 1,000 rad and CSA, 3 had graft survival greater than of 100 days. Of 15 baboons receiving TL1 800 rad and CSA, 6 had graft survival of greater than 100 days. In conclusion, CSA administration in dogs and TL1 in combination with CSA in baboons resulted in highly significant segmental pancreatic allograft survival.

Significant prolongation of segmental pancreatic allograft survival in two species

International Nuclear Information System (INIS)

Du Toit, D.F.; Heydenrych, J.J.

1988-01-01

A study was conducted to assess the suppression of segmental pancreatic allograft rejection by cyclosporine (CSA) alone in baboons and dogs, and subtotal marrow irradiation (TL1) alone and TL 1 in combination with CSA in baboons. Total pancreatectomy in the dog and primate provided a reliable diabetic model, induced an absolute deficiency of insulin and was uniformly lethal if not treated. Continuous administration of CSA in baboons resulted in modest allograft survival. As in baboons, dogs receiving CSA 25 mg/kg/d rendered moderate graft prolongation but a dose of 40 mg/kg/d resulted in significant graft survival (greater than 100 days) in 5 of 8 allograft recipients. Irradiation alone resulted in minimal baboon pancreatic allograft survival of 20 baboons receiving TL1 1,000 rad and CSA, 3 had graft survival greater than of 100 days. Of 15 baboons receiving TL1 800 rad and CSA, 6 had graft survival of greater than 100 days. In conclusion, CSA administration in dogs and TL1 in combination with CSA in baboons resulted in highly significant segmental pancreatic allograft survival

A shift from significance test to hypothesis test through power analysis in medical research

Directory of Open Access Journals (Sweden)

Singh Girish

2006-01-01

Full Text Available Medical research literature until recently, exhibited substantial dominance of the Fisher′s significance test approach of statistical inference concentrating more on probability of type I error over Neyman-Pearson′s hypothesis test considering both probability of type I and II error. Fisher′s approach dichotomises results into significant or not significant results with a P value. The Neyman-Pearson′s approach talks of acceptance or rejection of null hypothesis. Based on the same theory these two approaches deal with same objective and conclude in their own way. The advancement in computing techniques and availability of statistical software have resulted in increasing application of power calculations in medical research and thereby reporting the result of significance tests in the light of power of the test also. Significance test approach, when it incorporates power analysis contains the essence of hypothesis test approach. It may be safely argued that rising application of power analysis in medical research may have initiated a shift from Fisher′s significance test to Neyman-Pearson′s hypothesis test procedure.

Median of patient results as a tool for assessment of analytical stability.

Science.gov (United States)

Jørgensen, Lars Mønster; Hansen, Steen Ingemann; Petersen, Per Hyltoft; Sölétormos, György

2015-06-15

In spite of the well-established external quality assessment and proficiency testing surveys of analytical quality performance in laboratory medicine, a simple tool to monitor the long-term analytical stability as a supplement to the internal control procedures is often needed. Patient data from daily internal control schemes was used for monthly appraisal of the analytical stability. This was accomplished by using the monthly medians of patient results to disclose deviations from analytical stability, and by comparing divergences with the quality specifications for allowable analytical bias based on biological variation. Seventy five percent of the twenty analytes achieved on two COBASs INTEGRA 800 instruments performed in accordance with the optimum and with the desirable specifications for bias. Patient results applied in analytical quality performance control procedures are the most reliable sources of material as they represent the genuine substance of the measurements and therefore circumvent the problems associated with non-commutable materials in external assessment. Patient medians in the monthly monitoring of analytical stability in laboratory medicine are an inexpensive, simple and reliable tool to monitor the steadiness of the analytical practice. Copyright © 2015 Elsevier B.V. All rights reserved.

A Novel Least Significant Bit First Processing Parallel CRC Circuit

Directory of Open Access Journals (Sweden)

Xiujie Qu

2013-01-01

Full Text Available In HDLC serial communication protocol, CRC calculation can first process the most or least significant bit of data. Nowadays most CRC calculation is based on the most significant bit (MSB first processing. An algorithm of the least significant bit (LSB first processing parallel CRC is proposed in this paper. Based on the general expression of the least significant bit first processing serial CRC, using state equation method of linear system, we derive a recursive formula by the mathematical deduction. The recursive formula is applicable to any number of bits processed in parallel and any series of generator polynomial. According to the formula, we present the parallel circuit of CRC calculation and implement it with VHDL on FPGA. The results verify the accuracy and effectiveness of this method.

Human Body 3D Posture Estimation Using Significant Points and Two Cameras

Science.gov (United States)

Juang, Chia-Feng; Chen, Teng-Chang; Du, Wei-Chin

2014-01-01

This paper proposes a three-dimensional (3D) human posture estimation system that locates 3D significant body points based on 2D body contours extracted from two cameras without using any depth sensors. The 3D significant body points that are located by this system include the head, the center of the body, the tips of the feet, the tips of the hands, the elbows, and the knees. First, a linear support vector machine- (SVM-) based segmentation method is proposed to distinguish the human body from the background in red, green, and blue (RGB) color space. The SVM-based segmentation method uses not only normalized color differences but also included angle between pixels in the current frame and the background in order to reduce shadow influence. After segmentation, 2D significant points in each of the two extracted images are located. A significant point volume matching (SPVM) method is then proposed to reconstruct the 3D significant body point locations by using 2D posture estimation results. Experimental results show that the proposed SVM-based segmentation method shows better performance than other gray level- and RGB-based segmentation approaches. This paper also shows the effectiveness of the 3D posture estimation results in different postures. PMID:24883422

Oral heparin results in the appearance of heparin fragments in the plasma of rats

International Nuclear Information System (INIS)

Larsen, A.K.; Lund, D.P.; Langer, R.; Folkman, J.

1986-01-01

We have previously shown that angiogenesis inhibition and tumor regression can be accomplished by combinations of heparin or heparin fragments with cortisone. Oral heparin was also effective in combination with cortisone. We now show that a single oral dose of [ 35 S]heparin or [ 3 H]heparin (15,000 units/kg) results in continuous release of radioactive material into the bloodstream for at least 12 hr. This is associated with the presence of anti-factor Xa activity at a level of approximately equal to 0.1 unit/ml. The radioactive material is identified as oligo-, di-, and monosaccharides by its behavior in chromatographic systems, its possession of anti-factor Xa activity, and the effect of treatment with bacterial heparinase. The heparin fragments are extensively metabolized to fragments without anti-factor Xa activity that are readily subject to urinary excretion

Significant exposures to isoeugenol derivaties in perfumes

DEFF Research Database (Denmark)

Rastogi, Suresh Chandra; Johansen, Jeanne Duus

2008-01-01

in perfumes/aftershaves. MATERIALS AND METHODS: 29 international brand perfumes/aftershaves were analysed for the target fragrance ingredient by gas chromatography-mass spectrometry. All samples were analysed in duplicate at detection levels of 1-5 p.p.m. RESULTS: 16 products (55%) contained isoeugenol...... was not detected in any of the investigated products. CONCLUSIONS: Isoeugenyl acetate is present in perfumes/aftershaves, in some products in significant amounts. This may lead to elicitation of contact allergy in isoeugenol-sensitized individuals and may contribute to unchanged levels of isoeugenol sensitization....

Mechanical disruption of tumors by iron particles and magnetic field application results in increased anti-tumor immune responses.

Directory of Open Access Journals (Sweden)

Myriam N Bouchlaka

Full Text Available The primary tumor represents a potential source of antigens for priming immune responses for disseminated disease. Current means of debulking tumors involves the use of cytoreductive conditioning that impairs immune cells or removal by surgery. We hypothesized that activation of the immune system could occur through the localized release of tumor antigens and induction of tumor death due to physical disruption of tumor architecture and destruction of the primary tumor in situ. This was accomplished by intratumor injection of magneto-rheological fluid (MRF consisting of iron microparticles, in Balb/c mice bearing orthotopic 4T1 breast cancer, followed by local application of a magnetic field resulting in immediate coalescence of the particles, tumor cell death, slower growth of primary tumors as well as decreased tumor progression in distant sites and metastatic spread. This treatment was associated with increased activation of DCs in the draining lymph nodes and recruitment of both DCs and CD8(+T cells to the tumor. The particles remained within the tumor and no toxicities were observed. The immune induction observed was significantly greater compared to cryoablation. Further anti-tumor effects were observed when MRF/magnet therapy was combined with systemic low dose immunotherapy. Thus, mechanical disruption of the primary tumor with MRF/magnetic field application represents a novel means to induce systemic immune activation in cancer.

History and Accomplishments of USDA-ARS Avian Disease and Oncology Laboratory

Science.gov (United States)

The USDA-Agricultural Research Service Avian Disease and Oncology Laboratory (ADOL) in East Lansing, Michigan, formerly known as Regional Poultry Research Laboratory, was dedicated on August 8, 1939. Its establishment was the result of joint efforts by the Agricultural Experiment Stations of the Nor...

Mineral-microorganism interactions in Acid Mine Drainage environments: preliminary results

Science.gov (United States)

Carbone, Cristina; Zotti, Mirca; Pozzolini, Marina; Giovine, Marco; Di Piazza, Simone; Mariotti, Mauro; Lucchetti, Gabriella

2014-05-01

Minerals play a key role in controlling the mobility and distribution of metals and metalloids of environmental concern in supergenic environments. These are involved in a variety of processes, spanning the alteration of primary minerals to the formation of secondary authigenic phases and can represent a source or a trap for Potentially Ecotoxic Elements (PTEs). Soil, sediments, and waters heavily polluted with PTEs through AMD processes are a reservoir of a unusual bacteria and fungi well adapted to these toxic environments. Classical studies of biotic weathering have mainly focused on water-mineral interaction and on the ability of microorganism to influence the soil solution chemical composition. In this work, we analyzed two different representative ochreous and greenish-blue AMD colloidal precipitates in order to i) characterize the biota population present in these colloidal minerals and ii) verify the bioaccumulation of PTEs into the fungi and the potential impact of bacteria in the geochemistry of the system. The samples are composed by nanocrystalline goethite which contains high amounts of Fe, Cu, Zn, Pb, and Ni and woodwardite that is characterized by Cu, Zn, Ni, Y, and Ce. These precipitates were examined in order to evaluate the presence of fungal strains and to extract bacteria DNA. The preliminary results of fungi characterization show an interesting and selected mycobiota able to survive under unfavourable environmental conditions. A significant number of fungal strains was isolated in pure culture. Most of them belong to the genus Mucor and Penicillium. It is worth noting the presence of Trametes versicolor, a macrofungal lignicolous species already known for heavy metal biosorption capability from aqueous solution (Gülay et al 2003). The same colloidal precipitates have been processed to extract bacteria DNA, using a specific procedure developed for DNA extraction from sediments. The results gave a good yield of nucleic acids and the positive PCR

Environmental Assessment and Finding of No Significant Impact: Center for Integrated Nanotechnologies at Sandia National Laboratories/New Mexico

International Nuclear Information System (INIS)

2003-01-01

In 1999, the United States government announced the National Nanotechnology Initiative (NNI) that included a proposal directed at doubling the nation's investment in nanotechnology to ensure the United States' competitive position in the rapidly developing field of nanotechnology. As part of the NNI, the National Science and Technology Council Interagency Working Group on Nanoscale Science, Engineering, and Technology (IWGN) concluded that research centers would permit activities that cannot be accomplished in the traditional mode of small groups or single investigators or with the current research infrastructure. The IWGN recognized the importance of establishing research centers with major Department of Energy (DOE) specialized and user facilities. Consequently, the DOE Office of Basic Energy Sciences (OBES) plans to support the NNI, in part, through the establishment of an integrated national program of Nanoscale Science Research Centers (NSRC) affiliated with major facilities at DOE's national laboratories. Specific objectives of the NSRCs are to accomplish the following: (1) Advance the fundamental understanding and control of materials at the nanoscale regime; (2) Provide an environment to support research of a scope, complexity, and disciplinary breadth not possible under traditional investigator or small group efforts; (3) Provide the foundation for the development of nanotechnologies important to the DOE; (4) Provide state-of-the-art equipment to in-house laboratory, university, and industry researchers and optimize the use of national user facilities for materials characterization employing electrons, photons, and neutrons; (5) Provide a formal mechanism for both short- and long-term collaborations and partnerships among DOE laboratory, academic, and industrial researchers; and (6) Provide training for graduate students and postdoctoral associates in interdisciplinary nanoscale science, engineering, and technology research

Metamorphic history and geodynamic significance of the Early Cretaceous Sabzevar granulites (Sabzevar structural zone, NE Iran

Directory of Open Access Journals (Sweden)

M. Nasrabady

2011-11-01

Full Text Available The Iranian ophiolites are part of the vast orogenic suture zones that mark the Alpine-Himalayan convergence zone. Few petrological and geochronological data are available from these ophiolitic domains, hampering a full assessment of the timing and regimes of subduction zone metamorphism and orogenic construction in the region. This paper describes texture, geochemistry, and the pressure-temperature path of the Early Cretaceous mafic granulites that occur within the Tertiary Sabzevar ophiolitic suture zone of NE Iran. Whole rock geochemistry indicates that the Sabzevar granulites are likely derived from a MORB-type precursor. They are thus considered as remnants of a dismembered dynamo-thermal sole formed during subduction of a back-arc basin (proto-Sabzevar Ocean formed in the upper-plate of the Neotethyan slab. The metamorphic history of the granulites suggests an anticlockwise pressure-temperature loop compatible with burial in a hot subduction zone, followed by cooling during exhumation. Transition from a nascent to a mature stage of oceanic subduction is the geodynamic scenario proposed to accomplish for the reconstructed thermobaric evolution. When framed with the regional scenario, results of this study point to diachronous and independent tectonic evolutions of the different ophiolitic domains of central Iran, for which a growing disparity in the timing of metamorphic equilibration and of pressure-temperature paths can be expected to emerge with further investigations.

Impact significance determination-Pushing the boundaries

International Nuclear Information System (INIS)

Lawrence, David P.

2007-01-01

Impact significance determination practice tends to be highly variable. Too often insufficient consideration is given to good practice insights. Also, impact significance determinations are frequently narrowly defined addressing, for example, only individual, negative impacts, focusing on bio-physical impacts, and not seeking to integrate either the Precautionary Principle or sustainability. This article seeks to extend the boundaries of impact significance determination practice by providing an overview of good general impact significance practices, together with stakeholder roles and potential methods for addressing significance determination challenges. Relevant thresholds, criteria, contextual considerations and support methods are also highlighted. The analysis is then extended to address how impact significance determination practices change for positive as compared with negative impacts, for cumulative as compared with individual impacts, for socio-economic as compared with bio-physical impacts, when the Precautionary Principle is integrated into the process, and when sustainability contributions drive the EIA process and related impact significance determinations. These refinements can assist EIA practitioners in ensuring that the scope and nature of impact significance determinations reflect the broadened scope of emerging EIA requirements and practices. Suggestions are included for further refining and testing of the proposed changes to impact significance determination practice

Significant Radionuclides Determination

Energy Technology Data Exchange (ETDEWEB)

Jo A. Ziegler

2001-07-31

The purpose of this calculation is to identify radionuclides that are significant to offsite doses from potential preclosure events for spent nuclear fuel (SNF) and high-level radioactive waste expected to be received at the potential Monitored Geologic Repository (MGR). In this calculation, high-level radioactive waste is included in references to DOE SNF. A previous document, ''DOE SNF DBE Offsite Dose Calculations'' (CRWMS M&O 1999b), calculated the source terms and offsite doses for Department of Energy (DOE) and Naval SNF for use in design basis event analyses. This calculation reproduces only DOE SNF work (i.e., no naval SNF work is included in this calculation) created in ''DOE SNF DBE Offsite Dose Calculations'' and expands the calculation to include DOE SNF expected to produce a high dose consequence (even though the quantity of the SNF is expected to be small) and SNF owned by commercial nuclear power producers. The calculation does not address any specific off-normal/DBE event scenarios for receiving, handling, or packaging of SNF. The results of this calculation are developed for comparative analysis to establish the important radionuclides and do not represent the final source terms to be used for license application. This calculation will be used as input to preclosure safety analyses and is performed in accordance with procedure AP-3.12Q, ''Calculations'', and is subject to the requirements of DOE/RW-0333P, ''Quality Assurance Requirements and Description'' (DOE 2000) as determined by the activity evaluation contained in ''Technical Work Plan for: Preclosure Safety Analysis, TWP-MGR-SE-000010'' (CRWMS M&O 2000b) in accordance with procedure AP-2.21Q, ''Quality Determinations and Planning for Scientific, Engineering, and Regulatory Compliance Activities''.

Human-directed social behaviour in dogs shows significant heritability.

Science.gov (United States)

Persson, M E; Roth, L S V; Johnsson, M; Wright, D; Jensen, P

2015-04-01

Through domestication and co-evolution with humans, dogs have developed abilities to attract human attention, e.g. in a manner of seeking assistance when faced with a problem solving task. The aims of this study were to investigate within breed variation in human-directed contact seeking in dogs and to estimate its genetic basis. To do this, 498 research beagles, bred and kept under standardized conditions, were tested in an unsolvable problem task. Contact seeking behaviours recorded included both eye contact and physical interactions. Behavioural data was summarized through a principal component analysis, resulting in four components: test interactions, social interactions, eye contact and physical contact. Females scored significantly higher on social interactions and physical contact and age had an effect on eye contact scores. Narrow sense heritabilities (h(2) ) of the two largest components were estimated at 0.32 and 0.23 but were not significant for the last two components. These results show that within the studied dog population, behavioural variation in human-directed social behaviours was sex dependent and that the utilization of eye contact seeking increased with age and experience. Hence, heritability estimates indicate a significant genetic contribution to the variation found in human-directed social interactions, suggesting that social skills in dogs have a genetic basis, but can also be shaped and enhanced through individual experiences. This research gives the opportunity to further investigate the genetics behind dogs' social skills, which could also play a significant part into research on human social disorders such as autism. © 2015 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.

The Colorado Front Range Ecosystem Management Research Project: Accomplishments to date

Science.gov (United States)

Brian Kent; Wayne D. Shepperd; Deborah J. Shields

2000-01-01

This article briefly describes the goals and objectives for the Colorado Front Range Ecosystem Management Project (FREM). Research under this project has addressed both biophysical and human dimensions problems relating to ecosystem management in the Colorado Front Range. Results of completed work are described, and the status of the ongoing demonstration project at...

Cosmetic Evaluation of long term results following intraoperative radiotherapy (IORT) of conservative surgery for breast carcinoma

International Nuclear Information System (INIS)

Fussl, C. M.

2009-01-01

Introduction In breast conserving therapy (BCT) of breast cancer, cosmetic results have become next to tumor-related outcome parameters a criterion of increasing awareness. The aim of this study is the evaluation of long term cosmetic results after conservative surgery and intraoperative radiotherapy with 10 Gy electrons (IOERT), followed by whole breast radiotherapy (WBRT) with 50-54 Gy. Patients and Methods From October 1998 to October 2005, 818 patients (median age 57.89 years) were treated by IOERT during breast conserving surgery, 12 of them for bilateral cancer. 32 patients were referred to mastectomy within primary treatment, 50 were reported as dead at the beginning of the study, 4 patients had developed an in-breast-recurrence and had been salvaged by secondary mastectomy, and in 41 cases an intercurrent dissemination was noted. All 679 remaining patients were invited in written form to participate in the cosmesis study. 403 of them (59.4%) have answered and were object of the evaluation (August 2006 to April 2007). To provide reproducible examination conditions, a standardized photo-documentation in four positions (frontal, loose-hanging and elevated arms; left and right lateral, elevated arms) was accomplished. Patients and treating physicians evaluated the cosmetic results separately within a 5-point-score (Excellent, Good, Moderate, Bad, Complications). Patient-, tumor- and treatment-related factors were investigated with regard to possible impact on the cosmetic outcome in all patients (group 1). A separate subgroup analysis was carried out for 261 patients with a follow-up of at least three years after completion of local treatment (group 2). For computation of the statistic correlation between the variables and the cosmetic evaluation the rank correlation coefficients Kendall's τ Spearman's ρ were used. A correlation is significant below a p-value of 0.05. Results The self-assessment of the patients in group 1 yielded around 69% excellent, 25

Publication of statistically significant research findings in prosthodontics & implant dentistry in the context of other dental specialties.

Science.gov (United States)

Papageorgiou, Spyridon N; Kloukos, Dimitrios; Petridis, Haralampos; Pandis, Nikolaos

2015-10-01

To assess the hypothesis that there is excessive reporting of statistically significant studies published in prosthodontic and implantology journals, which could indicate selective publication. The last 30 issues of 9 journals in prosthodontics and implant dentistry were hand-searched for articles with statistical analyses. The percentages of significant and non-significant results were tabulated by parameter of interest. Univariable/multivariable logistic regression analyses were applied to identify possible predictors of reporting statistically significance findings. The results of this study were compared with similar studies in dentistry with random-effects meta-analyses. From the 2323 included studies 71% of them reported statistically significant results, with the significant results ranging from 47% to 86%. Multivariable modeling identified that geographical area and involvement of statistician were predictors of statistically significant results. Compared to interventional studies, the odds that in vitro and observational studies would report statistically significant results was increased by 1.20 times (OR: 2.20, 95% CI: 1.66-2.92) and 0.35 times (OR: 1.35, 95% CI: 1.05-1.73), respectively. The probability of statistically significant results from randomized controlled trials was significantly lower compared to various study designs (difference: 30%, 95% CI: 11-49%). Likewise the probability of statistically significant results in prosthodontics and implant dentistry was lower compared to other dental specialties, but this result did not reach statistical significant (P>0.05). The majority of studies identified in the fields of prosthodontics and implant dentistry presented statistically significant results. The same trend existed in publications of other specialties in dentistry. Copyright © 2015 Elsevier Ltd. All rights reserved.

Significant bacteriuria in children with sickle cell anaemia in a ...

African Journals Online (AJOL)

) may result in long term morbidity and mortality due to chronic renal dysfunction. Objectives: To evaluate the prevalence of significant bacteriuria among children with SCA and to determine their antimicrobial sensitivity patterns of isolates.

Novel silicone stent to treat tracheobronchial lesions: results of 35 patients.

Science.gov (United States)

Saueressig, Maurício G; Sanches, Paulo R S; Macedo Neto, Amarilio V; Moreschi, Alexandre H; Oliveira, Hugo G; Xavier, Rogerio G

2010-12-01

We describe a case series of 35 patients with either benign (14) or malignant (21) tracheal stenosis who were treated using a novel silicone stent, the HCPA-1, designed to prevent migration. Between March 2001 and September 2008, 13 women and 22 men received 41 HCPA-1 stents. The median duration of stenting in benign cases was 457 days (range, 4-2,961 days). Successful stent removal with curative results was accomplished in 2 patients with tracheomalacia and 1 with post-intubation stenosis. In malignant cases, the median duration of stenting was 162 days (range, 1-1,279 days). Five patients had tumor progression with obstruction requiring repeated laser resection, dilatation, or additional stents. Two patients died due to airway obstruction despite bronchoscopic intervention. Twelve patients with malignant lesions died with the stent in place. At the end of the study, 3 patients with malignant disease remained alive; 2 were lost to follow-up. The HCPA-1 stent proved to be safe, with no severe complications during the study period, and effective in improving quality of life with relief of dyspnea.

Exercise testing in patients with variant angina: results, correlation with clinical and angiographic features and prognostic significance

International Nuclear Information System (INIS)

Waters, D.D.; Szlachcic, J.; Bourassa, M.G.; Scholl, J.-M.; Theroux, P.

1982-01-01

Eighty-two patients with variant angina underwent a treadmill exercise test using 14 ECG leads, and 67 also underwent exercise thallium-201 scans. The test induced ST elevation in 25 patients (30%), ST depression in 21 (26%) and no ST-segment abnormality in 36 (44%). ST elevation during exercise occurred in the same ECG leads as during spontaneous attacks at rest, and was always associated with a large perfusion defect on the exercise thallium scan. In contrast, exercise-induced ST depression often did not occur in the leads that exhibited ST elevation during episodes at rest. The ST-segment response to exercise did not accurately predict coronary anatomy: Coronary stenoses greater than or equal to 70% were present in 14 of 25 patients (56%) with ST elevation, in 13 of 21 (62%) with ST depression and in 14 of 36 (39%) with no ST-segment abnormality (NS). However, the degree of disease activity did correlate with the result of the exercise test: ST elevation occurred during exercise in 11 of 14 patients who had an average of more than two spontaneous attacks per day, in 12 of 24 who had between two attacks per day and two per week, and in only two of 31 who had fewer than two attacks per week (p<0.005). ST elevation during exercise was reproducible in five of five patients retested during an active phase of their disease, but not in three of three patients who had been angina-free for a least 1 month before the repeat test. We conclude that in variant angina patients, the results of an exercise test correlate well with the degree of disease activity but not with coronary anatomy, and do not define a high-risk subgroup

Results of clinical and radiologic mass-screening tests of the locomotor system of miners in Hungary

Energy Technology Data Exchange (ETDEWEB)

Bene, E.; Temesvary, P.; Szilagyi, M.; Pera, F.

Clinical and radiological screening tests on the locomotor system of 250 workers being active in mines were accomplished by the authors. The test results of 125 miners working underground were compared with those of a control group consisting of equally 125 workers of the same age category, but engaged in open mining. As a result of the investigation it could be stated that miners working in underground mines were affected by diseases of the organs of motion at a very early stage, and in a greater proportion. The most serious deformations were observed with development irregularities and development variations. The development of degenerative locomotor diseases is promoted in Hungary by the working conditions prevailing underground. The completion of the examination procedure of fitness for work by clinical and radiological examinations of the locomotor system is important and highly recommended. The investigation carried out by the authors may serve as a model for the screening tests to be made on the locomotor system of industrial workers.

Accomplishment of highly porous-lithium lanthanum titanate through microwave treatment

Energy Technology Data Exchange (ETDEWEB)

Lakshmi, D.; Nalini, B., E-mail: jyothsnalalin99@gmail.com [Department of Physics, Avinashilingam University for Women, Coimbatore, Tamilnadu (India); Abhilash, K. P.; Selvin, P. Christopher [Department of Physics, NGM college for arts and science, Pollachi, Tamilnadu (India)

2016-05-23

Perovskite structured (ABO{sub 3}) lithium lanthanum titanate (LLTO) is a successful electrolyte reported by several scientists in the recent past. It is believed that intercalation and de-intercalation of Li ions inside solid electrolyte can be improved by increasing the porosity of the material. Hence in this research work, an attempt is made to increase the porosity of the LLTO electrolyte by rapid-microwave synthesis route. The microwave prepared LLTO is compared with the sol-gel synthesized LLTO. The prepared samples are analyzed with XRD, SEM, PL and cyclic Voltammetry studies. Morphological analysis proves that microwave synthesized LLTO contains much pores compared to the Sol-gel LLTO. A remarkable difference in its electrochemical property is also demonstrated and analysed with cyclic voltammetric studies and the results are presented.

Genome-wide identification of significant aberrations in cancer genome.

Science.gov (United States)

Yuan, Xiguo; Yu, Guoqiang; Hou, Xuchu; Shih, Ie-Ming; Clarke, Robert; Zhang, Junying; Hoffman, Eric P; Wang, Roger R; Zhang, Zhen; Wang, Yue

2012-07-27

Somatic Copy Number Alterations (CNAs) in human genomes are present in almost all human cancers. Systematic efforts to characterize such structural variants must effectively distinguish significant consensus events from random background aberrations. Here we introduce Significant Aberration in Cancer (SAIC), a new method for characterizing and assessing the statistical significance of recurrent CNA units. Three main features of SAIC include: (1) exploiting the intrinsic correlation among consecutive probes to assign a score to each CNA unit instead of single probes; (2) performing permutations on CNA units that preserve correlations inherent in the copy number data; and (3) iteratively detecting Significant Copy Number Aberrations (SCAs) and estimating an unbiased null distribution by applying an SCA-exclusive permutation scheme. We test and compare the performance of SAIC against four peer methods (GISTIC, STAC, KC-SMART, CMDS) on a large number of simulation datasets. Experimental results show that SAIC outperforms peer methods in terms of larger area under the Receiver Operating Characteristics curve and increased detection power. We then apply SAIC to analyze structural genomic aberrations acquired in four real cancer genome-wide copy number data sets (ovarian cancer, metastatic prostate cancer, lung adenocarcinoma, glioblastoma). When compared with previously reported results, SAIC successfully identifies most SCAs known to be of biological significance and associated with oncogenes (e.g., KRAS, CCNE1, and MYC) or tumor suppressor genes (e.g., CDKN2A/B). Furthermore, SAIC identifies a number of novel SCAs in these copy number data that encompass tumor related genes and may warrant further studies. Supported by a well-grounded theoretical framework, SAIC has been developed and used to identify SCAs in various cancer copy number data sets, providing useful information to study the landscape of cancer genomes. Open-source and platform-independent SAIC software is

The significance of appearance in physician-nurse collaboration

DEFF Research Database (Denmark)

Konradsen, H.; Christensen, O.M.; Berthelsen, C.

2009-01-01

INTRODUCTION: According to nurses' assessment, physician-nurse collaboration is problematic. The aim of the study was to investigate whether nurses believe physicians' appearances is significant for their ability to collaborate. MATERIAL AND METHODS: This is a single-blinded, quasi-experimental i......-depth interviews to achieve harmonic interaction leading to a prolific and close future collaboration Udgivelsesdato: 2009/12/14......INTRODUCTION: According to nurses' assessment, physician-nurse collaboration is problematic. The aim of the study was to investigate whether nurses believe physicians' appearances is significant for their ability to collaborate. MATERIAL AND METHODS: This is a single-blinded, quasi....... The Jefferson Scale of Attitudes Toward Physician-Nurse Collaboration will be used for baseline and follow-up study of the nurses' assessment. RESULTS: Due to ethical considerations, researchers had difficulties finding surgeons prepared to perform procedures aiming at weakening the physicians' physical...

The Significance of Loyalty on Consumer Credit Profitability

Directory of Open Access Journals (Sweden)

Aditya Galih Prihartono

2012-04-01

Full Text Available The purpose of this research is to analyze and test the effect of customer loyalty on consumer credit profitability. Loyalty Index Score was developed to determine the level of customers’ loyalty level through 4 main variables; Longevity, Depth, Breadth and Referrals. The effect of Loyalty Index Score on profitability was further tested by path analysis to find out the significance direct relationship between loyalty and profitablity and the indirect relationship between the two variable through bucket. The result showed that loyalty has a significant effect on profitability either directly or indirectly. It was concluded that direct loyalty effect on profitability is lower than that of the indirect effect through bucket. The conclusion could be made by analyzing the available data from personal loan customers in one of the biggest multinational bank in indonesia during October 2010 until March 2011.

The energetic significance of cooking.

Science.gov (United States)

Carmody, Rachel N; Wrangham, Richard W

2009-10-01

While cooking has long been argued to improve the diet, the nature of the improvement has not been well defined. As a result, the evolutionary significance of cooking has variously been proposed as being substantial or relatively trivial. In this paper, we evaluate the hypothesis that an important and consistent effect of cooking food is a rise in its net energy value. The pathways by which cooking influences net energy value differ for starch, protein, and lipid, and we therefore consider plant and animal foods separately. Evidence of compromised physiological performance among individuals on raw diets supports the hypothesis that cooked diets tend to provide energy. Mechanisms contributing to energy being gained from cooking include increased digestibility of starch and protein, reduced costs of digestion for cooked versus raw meat, and reduced energetic costs of detoxification and defence against pathogens. If cooking consistently improves the energetic value of foods through such mechanisms, its evolutionary impact depends partly on the relative energetic benefits of non-thermal processing methods used prior to cooking. We suggest that if non-thermal processing methods such as pounding were used by Lower Palaeolithic Homo, they likely provided an important increase in energy gain over unprocessed raw diets. However, cooking has critical effects not easily achievable by non-thermal processing, including the relatively complete gelatinisation of starch, efficient denaturing of proteins, and killing of food borne pathogens. This means that however sophisticated the non-thermal processing methods were, cooking would have conferred incremental energetic benefits. While much remains to be discovered, we conclude that the adoption of cooking would have led to an important rise in energy availability. For this reason, we predict that cooking had substantial evolutionary significance.

Significance of water fluxes in a deep arid-region vadose zone to waste disposal strategies

International Nuclear Information System (INIS)

Johnejack, K.R.; Blout, D.O.; Sully, M.J.; Emer, D.F.; Hammermeister, D.P.; Dever, L.G.; O'Neill, L.J.; Tyler, S.W.; Chapman, J.

1994-01-01

Recently collected subsurface site characterization data have led to the development of a conceptual model of water movement beneath the Area 5 Radioactive Waste Management Site (RWMS) at the Nevada Test Site (NTS) that differs significantly from the conceptual model of water movement inherent in Resource Conservation and Recovery Act (RCRA) regulations. At the Area 5 RWMS, water fluxes in approximately the upper 75 m (250 ft) of the vadose zone point in the upward direction (rather than downward) which effectively isolates this region from the deep (approximately 250 m (820 ft)) uppermost aquifer. Standard RCRA approaches for detection and containment (groundwater monitoring and double liners/leachate collection/leak detection systems) are not able to fulfill their intended function in this rather unique hydrogeologic environment. In order to better fulfill the waste detection and containment intentions of RCRA for mixed waste disposal at the Area 5 RWMS, the Department of Energy, Nevada Operations Office (DOE/NV) is preparing a single petition for both a waiver from groundwater monitoring and an exemption from double liners with leachate collection/leak detection. DOE/NV proposes in this petition that the containment function of liners and leachate collection is better accomplished by the natural hydrogeologic processes operating in the upper vadose zone; and the detection function of groundwater monitoring and the leak detection system in liners is better fulfilled by an alternative vadose zone monitoring system. In addition, an alternative point of compliance is proposed that will aid in early detection, as well as limit the extent of potential contamination before detection. Finally, special cell design features and operation practices will be implemented to limit leachate formation, especially while the cell is open to the atmosphere during waste emplacement

Significant Improvement of Catalytic Efficiencies in Ionic Liquids

International Nuclear Information System (INIS)

Song, Choong Eui; Yoon, Mi Young; Choi, Doo Seong

2005-01-01

The use of ionic liquids as reaction media can confer many advantages upon catalytic reactions over reactions in organic solvents. In ionic liquids, catalysts having polar or ionic character can easily be immobilized without additional structural modification and thus the ionic solutions containing the catalyst can easily be separated from the reagents and reaction products, and then, be reused. More interestingly, switching from an organic solvent to an ionic liquid often results in a significant improvement in catalytic performance (e.g., rate acceleration, (enantio)selectivity improvement and an increase in catalyst stability). In this review, some recent interesting results which can nicely demonstrate these positive 'ionic liquid effect' on catalysis are discussed

The prognostic significance of early treatment response in pediatric relapsed acute myeloid leukemia : results of the international study Relapsed AML 2001/01

NARCIS (Netherlands)

Creutzig, Ursula; Zimmermann, Martin; Dworzak, Michael N.; Gibson, Brenda; Tamminga, Rienk; Abrahamsson, Jonas; Ha, Shau-Yin; Hasle, Henrik; Maschan, Alexey; Bertrand, Yves; Leverger, Guy; von Neuhoff, Christine; Razzouk, Bassem; Rizzari, Carmelo; Smisek, Petr; Smith, Owen P.; Stark, Batia; Reinhardt, Dirk; Kaspers, Gertjan L.

2014-01-01

The prognostic significance of early response to treatment has not been reported in relapsed pediatric acute myeloid leukemia. In order to identify an early and easily applicable prognostic factor allowing subsequent treatment modifications, we assessed leukemic blast counts in the bone marrow by

Consumption of a healthy dietary pattern results in significant reductions in C-reactive protein levels in adults: a meta-analysis.

Science.gov (United States)

Neale, E P; Batterham, M J; Tapsell, L C

2016-05-01

Consumption of healthy dietary patterns has been associated with reduced risk of cardiovascular disease and metabolic syndrome. Dietary intervention targets disease prevention, so studies increasingly use biomarkers of underlying inflammation and metabolic syndrome progression to examine the diet-health relationship. The extent to which these biomarkers contribute to the body of evidence on healthy dietary patterns is unknown. The aim of this meta-analysis was to determine the effect of healthy dietary patterns on biomarkers associated with adiposity, insulin resistance, and inflammation in adults. A systematic search of Scopus, PubMed, Web of Science, and Cochrane Central Register of Controlled Trials (all years to April 2015) was conducted. Inclusion criteria were randomized controlled trials; effects of dietary patterns assessed on C-reactive protein (CRP), total adiponectin, high-molecular-weight adiponectin, tumor necrosis factor-α, adiponectin:leptin, resistin, or retinol binding protein 4. Random effects meta-analyses were conducted to assess the weighted mean differences in change or final mean values for each outcome. Seventeen studies were included in the review. These reflected research on dietary patterns associated with the Mediterranean diet, Nordic diet, Tibetan diet, and the Dietary Approaches to Stop Hypertension diet. Consumption of a healthy dietary pattern was associated with significant reductions in CRP (weighted mean difference, -0.75 [-1.16, -0.35]; P = .0003). Non-significant changes were found for all other biomarkers. This analysis found evidence for favorable effects of healthy dietary patterns on CRP, with limited evidence for other biomarkers. Future research should include additional randomized controlled trials incorporating a greater range of dietary patterns and biomarkers. Copyright © 2016 Elsevier Inc. All rights reserved.

ATE accomplishes receiver specification testing with increased speed and throughput

Science.gov (United States)

Moser, S. A.

1982-12-01

The use of automatic test equipment (ATE) for receiver specifications testing can result in a 90-95% reduction of test time, with a corresponding reduction of labor costs due both to the reduction of personnel numbers and a simplification of tasks that permits less skilled personnel to be employed. These benefits free high-level technicians for more challenging system management assignments. Accuracy and repeatability also improve with the adoption of ATE, since no possibility of human error can be introduced into the readings that are taken by the system. A massive and expensive software design and development effort is identified as the most difficult aspect of ATE implementation, since programming is both time-consuming and labor intensive. An attempt is therefore made by system manufacturers to conduct an integrated development program for both ATE system hardware and software.

Fumio Matsumura--accomplishments at the University of California, Davis, and in the Sierra Nevada Mountains.

Science.gov (United States)

Seiber, James N

2015-05-01

Fumio Matsumura joined the University of California, Davis, faculty in 1987 where he served as founding director of the Center for Environmental Health Sciences, associate director of the U.C. Toxic Substances Research and Teaching Program, and chair of the Department of Environmental Toxicology. He was an active affiliate with the NIEHS-funded Superfund Basic Research Program and the NIH Comprehensive Cancer Center. He was in many instances a primary driver or otherwise involved in most activities related to environmental toxicology at Davis, including the education of students in environmental biochemistry and ecotoxicology. A significant part of his broad research program was focused on the long range transport of chemicals such as toxaphene, PCBs and related contaminants used or released in California to the Sierra Nevada mountains, downwind of the urban and agricultural regions of the state. He hypothesized that these chemical residues adversely affected fish and wildlife, and particularly the declining populations of amphibians in Sierra Nevada streams and lakes. Fumio and his students and colleagues found residues of toxaphene and PCBs at higher elevations, an apparent result of atmospheric drift and deposition in the mountains. Fumio and his wife Teruko had personal interests in, and a love of the mountains, as avid skiers, hikers, and outdoor enthusiasts. Copyright © 2014 Elsevier Inc. All rights reserved.

Significant NRC Enforcement Actions

Data.gov (United States)

Nuclear Regulatory Commission — This dataset provides a list of Nuclear Regulartory Commission (NRC) issued significant enforcement actions. These actions, referred to as "escalated", are issued by...

REDUCTION OF ARSENIC WASTES IN THE SEMICONDUCTOR INDUSTRY

Science.gov (United States)

The research described in this report was aimed at initiating and developing processes and process modifications that could be incorporated into semiconductor manufacturing operations to accomplish pollution prevention, especially to accomplish significant reduction in the quanti...

Clinical and prognostic significance of plasma fibrinogen in lung cancer

Directory of Open Access Journals (Sweden)

Chen YS

2014-01-01

Full Text Available Objectives: Hyperfibrinogenemia is a common problem associated with various carcinomas. The recent studies have shown that high plasma fibrinogen concentration is associated with invasion, growth and metastases of cancer. Furthermore, the recent studies focus on the prognostic significance of fibrinogen in the patients with advanced NSCLC (stage IIIB -IV. However, the prognostic significance of the plasma fibrinogen levels in early stage NSCLC patients (stage I -IIIA still remains unclear. In addition, it remains unclear whether or not chemotherapy-induced changes in fibrinogen level relate to the prognosis. The aims of this study were to 1 further explore the relationship between the plasma fibrinogen concentration and the stage and metastases of lung cancer 2 evaluate the prognostic significance of the basal plasma fibrinogen level in patients with lung cancer 3 explore the prognostic value of the change in fibrinogen levels between pre and post-chemotherapy. Methods: In this retrospective study, the data from 370 patients with lung cancer were enrolled into this study. The plasma fibrinogen levels were compared with the clinical and prognostic significance of lung cancer. The association between the plasma fibrinogen level and clinical-prognostic characteristics were analyzed using SPSS 17.0 software. Results: 1 The median pre-treatment plasma fibrinogen levels were 4.20g/L. Pre-treatment plasma fibrinogen levels correlated significantly with gender (p = 0.013. A higher plasma fibrinogen concentration was associated with squamous cell carcinoma versus adenocarcinoma (4.83±1.50 g/L versus 4.15±1.30 g/L; P<0.001, there was a significant association between plasma fibrinogen level and metastases of lung cancer, pointing a higher plasma fibrinogen level in lymph nodes or distant organ metastases (p < 0.001. 2 Patients with low plasma fibrinogen concentration demonstrates higher overall survival compared with those with high plasma fibrinogen

Characterization and potential functional significance of human-chimpanzee large INDEL variation

Directory of Open Access Journals (Sweden)

Polavarapu Nalini

2011-10-01

Full Text Available Abstract Background Although humans and chimpanzees have accumulated significant differences in a number of phenotypic traits since diverging from a common ancestor about six million years ago, their genomes are more than 98.5% identical at protein-coding loci. This modest degree of nucleotide divergence is not sufficient to explain the extensive phenotypic differences between the two species. It has been hypothesized that the genetic basis of the phenotypic differences lies at the level of gene regulation and is associated with the extensive insertion and deletion (INDEL variation between the two species. To test the hypothesis that large INDELs (80 to 12,000 bp may have contributed significantly to differences in gene regulation between the two species, we categorized human-chimpanzee INDEL variation mapping in or around genes and determined whether this variation is significantly correlated with previously determined differences in gene expression. Results Extensive, large INDEL variation exists between the human and chimpanzee genomes. This variation is primarily attributable to retrotransposon insertions within the human lineage. There is a significant correlation between differences in gene expression and large human-chimpanzee INDEL variation mapping in genes or in proximity to them. Conclusions The results presented herein are consistent with the hypothesis that large INDELs, particularly those associated with retrotransposons, have played a significant role in human-chimpanzee regulatory evolution.

Safety significance of ATR [Advanced Test Reactor] passive safety response attributes

International Nuclear Information System (INIS)

Atkinson, S.A.

1989-01-01

The Advanced Test Reactor (ATR) at the Idaho National Engineering Laboratory was designed with some passive safety response attributes which contribute to the safety posture of the facility. The three passive safety attributes being evaluated in the paper are: (1) In-core and in-vessel natural convection cooling, (2) a passive heat sink capability of the ATR primary coolant system (PCS) for the transfer of decay power from the uninsulated piping to the confinement, and (3) gravity feed of emergency coolant makeup. The safety significance of the ATR passive safety response attributes is that the reactor can passively respond for most transients, given a reactor scram, to provide adequate decay power removal and a significant time for operator action should the normal active heat removal systems and their backup systems both fail. The ATR Interim Level 1 Probabilistic Risk Assessment (PRA) model ands results were used to evaluate the significance to ATR fuel damage frequency (or probability) of the above three passive response attributes. The results of the evaluation indicate that the first attribute is a major safety characteristic of the ATR. The second attribute has a noticeable but only minor safety significance. The third attribute has no significant influence on the ATR Level 1 PRA because of the diversity and redundancy of the ATR firewater injection system (emergency coolant system). 8 refs., 4 figs., 1 tab

FORCE STRUCTURE: Better Management Controls Are Needed to Oversee the Army's Modular Force and Expansion Initiatives and Improve Accountability for Results

National Research Council Canada - National Science Library

2007-01-01

.... For this report, GAO assessed to what extent the Army has accomplished the following: (1) implemented and established management controls for its modular force and force expansion initiatives, and (2...

RETROFIT COSTS FOR SO2 AND NOX CONTROL OPTIONS AT 200 COAL-FIRED PLANTS, VOLUME III - SITE SPECIFIC STUDIES FOR IN, KY, MA, MD, MI, MN

Science.gov (United States)

The report gives results of a study, the objective of which was to significantly improve engineering cost estimates currently being used to evaluate the economic effects of applying SO2 and NOx controls at 200 large SO2-emitting coal-fired utility plants. To accomplish the object...

RETROFIT COSTS FOR SO2 AND NOX CONTROL OPTIONS AT 200 COAL-FIRED PLANTS, VOLUME V - SITE SPECIFIC STUDIES FOR PA, SC, TN, VA, WI, WV

Science.gov (United States)

The report gives results of a study, the objective of which was to significantly improve engineering cost estimates currently being used to evaluate the economic effects of applying SO2 and NOx controls at 200 large SO2-emitting coal-fired utility plants. To accomplish the object...

RETROFIT COSTS FOR SO2 AND NOX CONTROL OPTIONS AT 200 COAL-FIRED PLANTS, VOLUME II - SITE SPECIFIC STUDIES FOR AL, DE. FL, GA, IL

Science.gov (United States)

The report gives results of a study, the objective of which was to significantly improve engineering cost estimates currently being used to evaluate the economic effects of applying SO2 and NOx controls at 200 large SO2-emitting coal-fired utility plants. To accomplish the object...

RETROFIT COSTS FOR SO2 AND NOX CONTROL OPTIONS AT 200 COAL-FIRED PLANTS, VOLUME IV - SITE SPECIFIC STUDIES FOR MO, MS, NC, NH, NJ, NY, OH

Science.gov (United States)

The report gives results of a study, the objective of which was to significantly improve engineering cost estimates currently being used to evaluate the economic effects of applying SO2 and NOx controls at 200 large SO2-emitting coal-fired utility plants. To accomplish the object...

RETROFIT COSTS FOR SO2 AND NOX CONTROL OPTIONS AT 200 COAL-FIRED PLANTS, VOLUME I - INTRODUCTION AND METHODOLOGY

Science.gov (United States)

The report gives results of a study, the objective of which was to significantly improve engineering cost estimates currently being used to evaluate the economic effects of applying SO2 and NOx controls at 200 large SO2-emitting coal-fired utility plants. To accomplish the object...

Accomplishments in free-piston stirling tests at NASA GRC

Science.gov (United States)

Schreiber, Jeffrey G.; Skupinski, Robert C.

2002-01-01

A power system based on the Stirling Radioisotope Generator (SRG) has been identified for potential use on deep space missions, as well as for Mars rovers that may benefit from extended operation. The Department of Energy (DOE) has responsibility for developing the generator and the NASA Glenn Research Center (GRC) is supporting DOE in this effort. The generator is based on a free-piston Stirling power convertor that has been developed by the Stirling Technology Company (STC) under contract to DOE. The generator would be used as a high-efficiency alternative to the Radioisotope Thermoelectric Generators (RTGs) that have been used on many previous missions. The increased efficiency leads to a factor of 3 to 4 reduction in the inventory of plutonium required to heat the generator. GRC has been involved in the development of Stirling power conversion technology for over 25 years. The support provided to this project by GRC has many facets and draws upon the lab's scientists and engineers that have gained experience in applying their skills to the previous Stirling projects. This has created a staff with an understanding of the subtleties involved in applying their expertise to Stirling systems. Areas include materials, structures, tribology, controls, electromagnetic interference, permanent magnets, alternator analysis, structural dynamics, and cycle performance. One of the key areas of support to the project is in the performance testing of the free-piston Stirling convertors. Since these power convertors are the smallest, lowest power Stirling machines that have been tested at GRC, a new laboratory was equipped for this project. Procedures and test plans have been created, instrumentation and data systems developed, and Stirling convertors have been tested. This paper will describe the GRC test facility, the test procedures that are used, present some of the test results and outline plans for the future. .

Clinical significance of measurement of hepatic volume by computed tomography

International Nuclear Information System (INIS)

Sato, Hiroyuki; Matsuda, Yoshiro; Takada, Akira

1984-01-01

Hepatic volumes were measured by computed tomography (CT) in 91 patients with chronic liver diseases. Mean hepatic volume in alcoholic liver disease was significantly larger than that in non-alcoholic liver disease. Hepatic volumes in the majority of decompensated liver cirrhosis were significantly smaller than those of compensated liver cirrhosis. In liver cirrhosis, significant correlations between hepatic volume and various hepatic tests which reflect the total functioning hepatic cell masses were found. Combinations of hepatic volume with ICG maximum removal rate and with serum cholinesterase activity were most useful for the assessment of prognosis in liver cirrhosis. These results indicated that estimation of hepatic volume by CT is useful for analysis of pathophysiology and prognosis of chronic liver diseases, and for diagnosis of alcoholic liver diseases. (author)

Accurate coding in sepsis: clinical significance and financial implications.

Science.gov (United States)

Chin, Y T; Scattergood, N; Thornber, M; Thomas, S

2016-09-01

Sepsis is a major healthcare problem and leading cause of death worldwide. UK hospital mortality statistics and payments for patient episodes of care are calculated on clinical coding data. The accuracy of these data depends on the quality of coding. This study aimed to investigate whether patients with significant bacteraemia are coded for sepsis and to estimate the financial costs of miscoding. Of 54 patients over a one-month period with a significant bacteraemia, only 19% had been coded for sepsis. This is likely to lead to falsely high calculated hospital mortality. Furthermore, this resulted in an underpayment of £21,000 for one month alone. Copyright © 2016 The Healthcare Infection Society. All rights reserved.

Hyperspectral Technology Transfer to the US Department of Interior: Summary of Results of the NASA/DOI Hyperspectral Technology Transfer Project

Science.gov (United States)

Root, Ralph; Wickland, Diane

2001-01-01

In 1997 the Office of Biological Informatics and Outreach (OBIO), Biological Resources Division, US Geological Survey and NASA, Office of Earth Science (OES), initiated a coordinated effort for applying Airborne Visible and Infrared Imaging Spectrometer (AVIRIS) data and analysis, as a technology transfer project, to critical DOI environmental issues in four study sites throughout the United States. This work was accomplished by four US Department of the Interior (DOI) study teams with support from NASA/OES principal investigators and the Office of Earth Science programs. The studies, including personnel, objectives, background, project plans, and milestones were documented in a project website at . This report summarizes the final outcomes of the project, detailing accomplishments, lessons learned, and benefits realized to NASA, the US Geological Survey, and the participating DOI bureaus.

Main results and status of the development of LEU fuel for Russian research reactors

International Nuclear Information System (INIS)

Vatulin, A.; Morozov, A.; Suprun, V.; Dobrikova, I.

2005-01-01

VNIINM develops low enrichment uranium (LEU) fuel on base U-Mo alloys and a novel design of pin-type fuel elements. The development is carried out both for existing reactors, and for new advanced designs of reactors. The work is carried on the following main directions: - irradiate LEU U-Mo dispersion fuel (the uranium density up to 6,0 g/cm 3 ) in two Russian research reactors: MIR (RIAR, Dimitrovgrad) as pin type fuel mini-elements and in WWR-M (PINP, Gatchina) within full-scaled fuel assembly (FA) with pin type fuel elements; - finalize development of design and fabrication process of IRT type FA with pin type fuel elements; - develop methods of reducing of U-Mo fuel --Al matrix interaction under irradiation; - develop fabricating methods of fuel elements on base of monolithic U-Mo fuel. The paper generally reviews the results of calculation, design and technology investigations accomplished by now. (author)

Dutch healthcare reform: did it result in performance improvement of health plans? A comparison of consumer experiences over time.

NARCIS (Netherlands)

Hendriks, M.; Spreeuwenberg, P.; Rademakers, J.; Delnoij, D.M.J.

2009-01-01

BACKGROUND: Many countries have introduced elements of managed competition in their healthcare system with the aim to accomplish more efficient and demand-driven health care. Simultaneously, generating and reporting of comparative healthcare information has become an important quality-improvement

Experimental results from Stripa

International Nuclear Information System (INIS)

Hood, M.

1979-06-01

The results indicate that the temperature fields in a rock mass containing geologic discontinuities can be predicted accurately using the simple theory of heat conduction. Geologic discontinuities appear to introduce significant nonlinear thermomechanical deformation into the rock mass, as a result of which the thermally induced displacements are much less than those predicted by the simple theory of thermo-elasticity. In addition, the assumption that the rock properties are temperature independent appears to increase the values predicted for these displacements significantly. Therefore, it is important that the temperature dependence of these properties is known and that these values be used in the calculations. The onset of significant thermal spalling along the walls of the heater boreholes appears to be related to conditions where the maximum induced compressive stress exceeds the uniaxial compressive strength of the rock. 7 figures

Materials International Space Station Experiment (MISSE): Overview, Accomplishments and Future Needs

Science.gov (United States)

deGroh, Kim K.; Jaworske, Donald A.; Pippin, Gary; Jenkins, Philip P.; Walters, Robert J.; Thibeault, Sheila A.; Palusinski, Iwona; Lorentzen, Justin R.

2014-01-01

8, yielding long-duration space environmental performance and durability data that enable material validation, processing recertification and space qualification; improved predictions of materials and component lifetimes in space; model verification and development; and correlation factors between space-exposure and ground-facilities enabling more accurate in-space performance predictions based on ground-laboratory testing. A few of the many experiment results and observations, and their impacts, are provided. Those highlighted include examples on improved understanding of atomic oxygen scattering mechanisms, LEO coating durability results, and polymer erosion yields and their impacts on spacecraft design. The MISSE 2 Atomic Oxygen Scattering Chamber Experiment discovered that the peak flux of scattered AO was determined to be 45 deg from normal incidence, not the model predicted cosine dependence. In addition, the erosion yield (E(sub y)) of Kapton H for AO scattered off oxidized-Al is 22% of the E(sub y) of direct AO impingement. These results were used to help determine the degradation mechanism of a cesium iodide detector within the Hubble Space Telescope Cosmic Origins Spectrograph Experiment. The MISSE 6 Indium Tin Oxide (ITO) Degradation Experiment measured surface electrical resistance of ram and wake ITO coated samples. The data confirmed that ITO is a stable AO protective coating, and the results validated the durability of ITO conductive coatings for solar arrays for the Atmosphere-Space Transition 2 Explorer program. The MISSE 2, 6 and 7 Polymer Experiments have provided LEO AO Ey data on over 120 polymer and composites samples. The flight E(sub y) values were found to range from 3.05 x 10(exp -26) cu cm/atom for the AO resistant polymer CORIN to 9.14 x 10(exp -26) cu cm/atom for polyoxymethylene (POM). In addition, flying the same polymers on different missions has advanced the understanding of the AO E(sub y) dependency on solar exposure for polymers

Understanding significant others' experience of aphasia and rehabilitation following stroke.

Science.gov (United States)

Hallé, Marie-Christine; Le Dorze, Guylaine

2014-01-01

It is currently unknown how rehabilitation services contribute to significant others' adjustment to stroke with aphasia since their experience of rehabilitation has not been studied before. The purpose of this study was thus to understand significant others' experience of aphasia rehabilitation within the context of post-stroke rehabilitation. Individual interviews were carried out with 12 significant others of persons who became aphasic as a result of a stroke and were discharged from rehabilitation in the past 3 months. Data were analyzed with a grounded theory approach. "Being centered on the aphasic person" was the core category triggered by the significant other's perception of the stroke survivor's vulnerability and his/her feelings of attachment towards that person. Through their interactions with professionals, significant others assumed that rehabilitation was also centered on the aphasic person; a perspective that was reinforced. Consequently, significant others participated in rehabilitation as caregivers and expected rehabilitation to meet their caregiver needs but not other personal and relational needs. Their appraisal of rehabilitation was thus related to the satisfaction or not of caregiver needs. With a greater sensitivity to significant others who focus on the stroke survivor and disregard their own needs, rehabilitation professionals and especially speech-language therapists, can assist families in reestablishing communication and satisfying relationships which are affected because of aphasia. This qualitative study shows that significant others of aphasic stroke survivors experience rehabilitation as services focused on the person who had the stroke. Significant others' satisfaction with rehabilitation is not related to the fulfillment of their personal (e.g. resuming their activities) and relational needs (e.g. good communication with the person with aphasia). When offering interventions targeting significant others' needs, rehabilitation

Tundra permafrost thaw causes significant shifts in energy partitioning

Directory of Open Access Journals (Sweden)

Christian Stiegler

2016-04-01

Full Text Available Permafrost, a key component of the arctic and global climate system, is highly sensitive to climate change. Observed and ongoing permafrost degradation influences arctic hydrology, ecology and biogeochemistry, and models predict that rapid warming is expected to significantly reduce near-surface permafrost and seasonally frozen ground during the 21st century. These changes raise concern of how permafrost thaw affects the exchange of water and energy with the atmosphere. However, associated impacts of permafrost thaw on the surface energy balance and possible feedbacks on the climate system are largely unknown. In this study, we show that in northern subarctic Sweden, permafrost thaw and related degradation of peat plateaus significantly change the surface energy balance of three peatland complexes by enhancing latent heat flux and, to less degree, also ground heat flux at the cost of sensible heat flux. This effect is valid at all radiation levels but more pronounced at higher radiation levels. The observed differences in flux partitioning mainly result from the strong coupling between soil moisture availability, vegetation composition, albedo and surface structure. Our results suggest that ongoing and predicted permafrost degradation in northern subarctic Sweden ultimately result in changes in land–atmosphere coupling due to changes in the partitioning between latent and sensible heat fluxes. This in turn has crucial implications for how predictive climate models for the Arctic are further developed.

The Radioactive Waste Management Advisory Committee's advice to ministers on the establishment of scientific consensus on the interpretation and significance of the results of science programmes into radioactive waste disposal

International Nuclear Information System (INIS)

1999-04-01

This document presents conclusions and recommendations on establishment of scientific consensus on the interpretation and significance of the results of science programmes into radioactive waste disposal. The topics discussed include: the nature of science and its limitations; societal views of science and the radioactive waste problem; issues upon which consensus will be needed; evidence of past attempts at greater involvement of the public; the linking of scientific and social consensus; communicating the nature of consensus to the public

Computation of spatial significance of mountain objects extracted from multiscale digital elevation models

International Nuclear Information System (INIS)

Sathyamoorthy, Dinesh

2014-01-01

The derivation of spatial significance is an important aspect of geospatial analysis and hence, various methods have been proposed to compute the spatial significance of entities based on spatial distances with other entities within the cluster. This paper is aimed at studying the spatial significance of mountain objects extracted from multiscale digital elevation models (DEMs). At each scale, the value of spatial significance index SSI of a mountain object is the minimum number of morphological dilation iterations required to occupy all the other mountain objects in the terrain. The mountain object with the lowest value of SSI is the spatially most significant mountain object, indicating that it has the shortest distance to the other mountain objects. It is observed that as the area of the mountain objects reduce with increasing scale, the distances between the mountain objects increase, resulting in increasing values of SSI. The results obtained indicate that the strategic location of a mountain object at the centre of the terrain is more important than its size in determining its reach to other mountain objects and thus, its spatial significance

23 CFR 630.1010 - Significant projects.

Science.gov (United States)

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Significant projects. 630.1010 Section 630.1010 Highways... PRECONSTRUCTION PROCEDURES Work Zone Safety and Mobility § 630.1010 Significant projects. (a) A significant project is one that, alone or in combination with other concurrent projects nearby is anticipated to cause...

Regularities of socially significant functions formation in pupils

Directory of Open Access Journals (Sweden)

Hrebniak N.P.

2016-05-01

Full Text Available The article focused on the results of carried out research of the functional state of the pupils’ organism in a process of edu­cational activity. It has been shown that formative influence of activity is manifested on the different levels of develop­ment of socially important functions: the actual developmental zone (priority development of indicators, which have the main significance in the activity and the proximal developmental zone (tendency of activation of the key functions.

Significant Association of Streptococcus bovis with Malignant Gastrointestinal Diseases

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Salah Shanan

2011-01-01

Full Text Available Streptococcus bovis is a Gram-positive bacterium causing serious human infections, including endocarditis and bacteremia, and is usually associated with underlying disease. The aims of the current study were to compare prevalence of the bacterium associated with malignant and nonmalignant gastrointestinal diseases and to determine the susceptibility of the isolated strains to different antimicrobial agents. The result showed that the prevalence of S. bovis in stool specimens from patients with malignant or with nonmalignant gastrointestinal diseases was statistically significant. This result may support the idea that there is correlation between S. bovis and the malignant gastrointestinal diseases.

Creating Significant Learning Experiences across Disciplines

Science.gov (United States)

Levine, Laura E.; Fallahi, Carolyn R.; Nicoll-Senft, Joan M.; Tessier, Jack T.; Watson, Cheryl L.; Wood, Rebecca M.

2008-01-01

The purpose of this study was to use Fink's (2003) taxonomy of significant learning to redesign courses and assess student learning. Significant improvements were found across the semester for students in the six courses, but there were differences in which taxa showed improvement in each course. The meta-analysis showed significant, positive…

Human Factors Engineering and Ergonomics Analysis for the Canister Storage Building (CSB) Results and Findings

Energy Technology Data Exchange (ETDEWEB)

GARVIN, L.J.

1999-09-20

The purpose for this supplemental report is to follow-up and update the information in SNF-3907, Human Factors Engineering (HFE) Analysis: Results and Findings. This supplemental report responds to applicable U.S. Department of Energy Safety Analysis Report review team comments and questions. This Human Factors Engineering and Ergonomics (HFE/Erg) analysis was conducted from April 1999 to July 1999; SNF-3907 was based on analyses accomplished in October 1998. The HFE/Erg findings presented in this report and SNF-3907, along with the results of HNF-3553, Spent Nuclear Fuel Project, Final Safety Analysis Report, Annex A, ''Canister Storage Building Final Safety Analysis Report,'' Chapter A3.0, ''Hazards and Accidents Analyses,'' provide the technical basis for preparing or updating HNF-3553. Annex A, Chaptex A13.0, ''Human Factors Engineering.'' The findings presented in this report allow the HNF-3553 Chapter 13.0, ''Human Factors,'' to respond fully to the HFE requirements established in DOE Order 5480.23, Nuclear Safety Analysis Reports.

Planck 2013 results. I. Overview of products and scientific results

CERN Document Server

Ade, P.A.R.; Armitage-Caplan, C.; Arnaud, M.; Ashdown, M.; Atrio-Barandela, F.; Aumont, J.; Baccigalupi, C.; Banday, A.J.; Barreiro, R.B.; Bartelmann, M.; Bartlett, J.G.; Battaner, E.; Benabed, K.; Benoit, A.; Benoit-Levy, A.; Bernard, J.P.; Bersanelli, M.; Bielewicz, P.; Bobin, J.; Bock, J.J.; Bonaldi, A.; Bond, J.R.; Borrill, J.; Bouchet, F.R.; Boulanger, F.; Bowyer, J.W.; Bridges, M.; Bucher, M.; Burigana, C.; Butler, R.C.; Cappellini, B.; Cardoso, J.F.; Carr, R.; Casale, M.; Catalano, A.; Challinor, A.; Chamballu, A.; Chary, R.R.; Chen, X.; Chiang, L.Y.; Chiang, H.C.; Christensen, P.R.; Church, S.; Clements, D.L.; Colombi, S.; Colombo, L.P.L.; Couchot, F.; Coulais, A.; Crill, B.P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R.D.; Davis, R.J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Delouis, J.M.; Desert, F.X.; Dickinson, C.; Diego, J.M.; Dole, H.; Donzelli, S.; Dore, O.; Douspis, M.; Dunkley, J.; Dupac, X.; Efstathiou, G.; Ensslin, T.A.; Eriksen, H.K.; Falgarone, E.; Finelli, F.; Foley, S.; Forni, O.; Frailis, M.; Franceschi, E.; Freschi, M.; Fromenteau, S.; Gaier, T.C.; Galeotta, S.; Gallegos, J.; Gandolfo, B.; Ganga, K.; Giard, M.; Giardino, G.; Giraud-Heraud, Y.; Gonzalez-Nuevo, J.; Gorski, K.M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Haissinski, J.; Hansen, F.K.; Hanson, D.; Harrison, D.; Helou, G.; Henrot-Versille, S.; Hernandez-Monteagudo, C.; Herranz, D.; Hildebrandt, S.R.; Hivon, E.; Hobson, M.; Holmes, W.A.; Hornstrup, A.; Hovest, W.; Huffenberger, K.M.; Jaffe, T.R.; Jaffe, A.H.; Jewell, J.; Jones, W.C.; Juvela, M.; Kangaslahti, P.; Keihanen, E.; Keskitalo, R.; Kisner, T.S.; Kneissl, R.; Knoche, J.; Knox, L.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lahteenmaki, A.; Lamarre, J.M.; Lasenby, A.; Laureijs, R.J.; Lawrence, C.R.; Le Jeune, M.; Leach, S.; Leahy, J.P.; Leonardi, R.; Leon-Tavares, J.; Leroy, C.; Lesgourgues, J.; Liguori, M.; Lilje, P.B.; Linden-Vornle, M.; Lopez-Caniego, M.; Lowe, S.; Lubin, P.M.; Macias-Perez, J.F.; Maffei, B.; Maino, D.; Mandolesi, N.; Maris, M.; Marshall, D.J.; Martin, P.G.; Martinez-Gonzalez, E.; Masi, S.; Matarrese, S.; Matthai, F.; Mazzotta, P.; McDonald, A.; McGehee, P.; Meinhold, P.R.; Melchiorri, A.; Melin, J.B.; Mendes, L.; Mennella, A.; Migliaccio, M.; Miniscalco, R.; Mitra, S.; Miville-Deschenes, M.A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J.A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C.B.; Norgaard-Nielsen, H.U.; North, C.; Noviello, F.; Novikov, D.; Novikov, I.; O'Dwyer, I.J.; Osborne, S.; Oxborrow, C.A.; Paci, F.; Pagano, L.; Pajot, F.; Paladini, R.; Paoletti, D.; Partridge, B.; Pasian, F.; Patanchon, G.; Pearson, D.; Pearson, T.J.; Perdereau, O.; Perotto, L.; Perrotta, F.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Platania, P.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Popa, L.; Poutanen, T.; Pratt, G.W.; Prezeau, G.; Prunet, S.; Puget, J.L.; Rachen, J.P.; Reach, W.T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Ricciardi, S.; Riller, T.; Ringeval, C.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rowan-Robinson, M.; Rubino-Martin, J.A.; Rusholme, B.; Salerno, E.; Sandri, M.; Santos, D.; Savini, G.; Scott, D.; Seiffert, M.D.; Shellard, E.P.S.; Smoot, G.F.; Spencer, L.D.; Starck, J.L.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sureau, F.; Sutton, D.; Suur-Uski, A.S.; Sygnet, J.F.; Tauber, J.A.; Tavagnacco, D.; Taylor, D.; Terenzi, L.; Texier, D.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Turler, M.; Tuttlebee, M.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Varis, J.; Vibert, L.; Vielva, P.; Villa, F.; Vittorio, N.; Wade, L.A.; Wandelt, B.D.; Watson, R.; Watson, C.; White, M.; White, S.D.M.; Wilkinson, A.; Yvon, D.; Zacchei, A.; Zonca, A.

2014-01-01

The ESA's Planck satellite, dedicated to studying the early universe, was launched on May 2009 and has been surveying the microwave and submillimetre sky since August 2009. In March 2013, ESA and the Planck Collaboration publicly released the initial cosmology products based on the first 15.5 months of Planck operations, along with a set of scientific and technical papers and a web-based explanatory supplement. This paper describes the mission and its performance, and gives an overview of the processing and analysis of the data, the characteristics of the data, the main scientific results, and the science data products and papers in the release. Scientific results include robust support for the standard, six parameter LCDM model of cosmology and improved measurements for the parameters that define this model, including a highly significant deviation from scale invariance of the primordial power spectrum. The Planck values for some of these parameters and others derived from them are significantly different fr...

Implementing Environmental Practices for Accomplishing Sustainable Green Supply Chain Management

Directory of Open Access Journals (Sweden)

Minkyun Kim

2017-07-01

Full Text Available With the emergence of environmental protection as a global issue, implementing environmental practices for sustaining green supply chain management (GSCM has received a lot of attention. This study investigates the impact of integration with suppliers and supply disruption risk on environmental practices. It also examines the role of supplier integration and supply disruption risk on performance. Finally, it investigates the relationship between environmental practices and performance in order to sustain green supply chains. Based on 272 survey responses from supply and purchase managers, our research results support the positive impact of integration with suppliers and the negative impact of supply disruption risk on the adoption of environmental practices. Furthermore, they provide empirical evidence that environmental practices and integration with suppliers are positively associated with performance, while supply disruption risk is negatively associated with performance. This study identifies antecedents and establishes a research framework of GSCM. More importantly, it provides meaningful insights to managers regarding the implementation of environmental practices related to other supply chain practices for sustaining green supply chains.

IMAGE STEGANOGRAPHY DENGAN METODE LEAST SIGNIFICANT BIT (LSB

Directory of Open Access Journals (Sweden)

M. Miftakul Amin

2014-02-01

Full Text Available Security in delivering a secret message is an important factor in the spread of information in cyberspace. Protecting that message to be delivered to the party entitled to, should be made a message concealment mechanism. The purpose of this study was to hide a secret text message into digital images in true color 24 bit RGB format. The method used to insert a secret message using the LSB (Least Significant Bit by replacing the last bit or 8th bit in each RGB color component. RGB image file types option considering that messages can be inserted capacity greater than if use a grayscale image, this is because in one pixel can be inserted 3 bits message. Tests provide results that are hidden messages into a digital image does not reduce significantly the quality of the digital image, and the message has been hidden can be extracted again, so that messages can be delivered to the recipient safely.

Burnout among hospital nurses in China.

Science.gov (United States)

Lin, Frances; St John, Winsome; McVeigh, Carol

2009-04-01

The aim of this study was to examine the level of burnout and factors that contribute to burnout in hospital nurses in the People's Republic of China. While burnout among hospital nurses has been widely researched in western countries, little research has investigated burnout among hospital nurses in China. A translated version of the Maslach Burnout Inventory-Human Services Survey was used to measure burnout in 249 randomly selected nurses from various wards of a large teaching hospital in Beijing, China. Questionnaire packs were sent to the hospital wards where selected nurses worked. One hundred and twenty-eight nurses returned the completed questionnaire. The response rate was 51%. The results showed moderate levels of Emotional Exhaustion and Personal Accomplishment, and low levels of Depersonalization. Age, years of experience and professional title had a significant positive relationship with Emotional Exhaustion and Personal Accomplishment. Older, married nurses with more personal responsibilities and in a more senior position experienced higher levels of Emotional Exhaustion. The findings suggest that burnout is a significant issue for nurses in China. The results of this study indicate that working environment factors such as relationships with coworkers and managers may contribute to or mitigate burnout. There is a need to address personal and professional support, life-work balance, personal accomplishment and educational programmes to reduce burnout in nurses working in China.

Significance of perfectionism in understanding different forms of insomnia

Directory of Open Access Journals (Sweden)

Totić-Poznanović Sanja

2012-01-01

Full Text Available Introduction. Studies consistently show a connection between perfectionism as a multidimensional construct with various psychological and psychopathological states and characteristics. However, studies that analyze the connection between this concept and sleep disturbances, especially modalities of insomnia, are rare. Objective. The aim of this study was to examine whether dimensions of perfectionism can explain different forms of insomnia; difficulties initiating sleep (insomnia early, difficulties during the sleep (insomnia middle, waking in early hours of the morning (insomnia late and dissatisfaction with sleep quality (subjective insomnia. Methods. The sample consisted of 254 students of the School of Medicine in Belgrade. Predictive significance of nine perfectionism dimensions, measured by Frost’s and Hewitt’s and Flett’s scales of multi-dimensional perfectionism, related to four modalities of insomnia, measured by a structured questionnaire, was analyzed by multiple linear regression method. Results. Perfectionism dimensions are significant predictors of each of the tested forms of insomnia. Doubt about actions significantly predicts initial insomnia; to other-oriented perfectionism in the negative pole and socially prescribed perfectionism underlie the difficulties during the sleep, while organization and parental criticism underlie late insomnia. Significant predictors of subjective insomnia are personal standards and organization and to other-oriented perfectionism on the negative pole. Three of nine analyzed dimensions were not confirmed as significant; concern over mistakes, parental expectations and self-oriented perfectionism. Conclusion. Various aspects of perfectionism can be considered as a vulnerability factor for understanding some forms of insomnia. Out of all forms of insomnia tested, perfectionism as the personality trait proved to be the most significant for understanding subjective insomnia.

Gastric cancer in New Mexico counties with significant deposits of uranium

International Nuclear Information System (INIS)

Wilkinson, G.S.

1985-01-01

Several counties in northern New Mexico display high rates of mortality from gastric cancer. Significant differences in sex-specific, age-adjusted, average annual stomach cancer mortality rates among whites from 1970-1979 were found between counties with significant deposits of uranium compared to those without significant deposits. These results remained unchanged when either socioeconomic status or Hispanic ethnicity were considered. Additional research needs to consider individual characteristics and competing risk factors for individuals with gastric cancer in these counties. A working hypothesis is that residents of counties with significant deposits of uranium are exposed to higher-than-average environmental levels of radionuclides such as radon and radon daughters, or to trace elements such as arsenic, cadmium, selenium, and lead which are commonly found in areas with uranium deposits

Modifications resulting in significant increases in the beam usage time of a 60 keV electron beam welder

International Nuclear Information System (INIS)

Zielinski, R.E.; Harrison, J.L.

1976-01-01

Short beam usage times were encountered using a 60 keV electron beam welder. These short times were the direct result of a buildup of a reaction product (WO 2 . 90 ) that occurred on graphite washers which housed the tungsten emitter plate. While it was not possible to prevent the reaction product, its growth rate was sufficiently altered by changing graphite materials and minor design changes of the washers. With these modifications beam usage times increased from an original 40 min to approximately 675 min