Compact assembly generates plastic foam, inflates flotation bag

Science.gov (United States)

1965-01-01

Device for generating plastic foam consists of an elastomeric bag and two containers with liquid resin and a liquid catalyst. When the walls of the containers are ruptured the liquids come into contact producing foam which inflates the elastomeric bag.

Detecting leaks in vacuum bags

Science.gov (United States)

Carlstrom, E. E.

1980-01-01

Small leaks in vacuum bag can be readily detected by eye, using simple chemical reaction: combination of ammonia and acetic acid vapors to produce cloudy white smoke. Technique has been successfully used to test seam integrity and to identify minute pinholes in vacuum bag used in assembly of ceramic-tile heat shield for Space Shuttle Orbiter.

An analytical hierarchy process-based study on the factors affecting legislation on plastic bags in the USA.

Science.gov (United States)

Li, Zhongguo; Zhao, Fu

2017-08-01

Annually, a large number of used plastic shopping bags are released into the environment, posing significant threats to public health and wildlife. Owing to these concerns, many local, regional, and national governments around the world have passed legislation to ban or restrict the use of plastic shopping bags. However, in the USA there are only 18 states that have approved plastic bag bans/fees, and even within these states these regulations do not cover all cities or counties. There are many factors that could affect the development and implementation of these regulations. This article employs an analytical hierarchy process to analyse the factors that could impact the enactment of plastic bag regulations. Five impact factors are identified based on statistical data, that is, geographical location, interest of industry achievable, cost of living, level of economic development, and educational level of population. The weights of the five impact factors are determined and it is found that the possibility of banning or restricting plastic bags in general follows a certain pattern among all states.

Modeling the Hybrid Flow Shop Scheduling Problem Followed by an Assembly Stage Considering Aging Effects and Preventive Maintenance Activities

Directory of Open Access Journals (Sweden)

Seyyed Mohammad Hassan Hosseini

2016-05-01

Full Text Available Scheduling problem for the hybrid flow shop scheduling problem (HFSP followed by an assembly stage considering aging effects additional preventive and maintenance activities is studied in this paper. In this production system, a number of products of different kinds are produced. Each product is assembled with a set of several parts. The first stage is a hybrid flow shop to produce parts. All machines can process all kinds of parts in this stage but each machine can process only one part at the same time. The second stage is a single assembly machine or a single assembly team of workers. The aim is to schedule the parts on the machines and assembly sequence and also determine when the preventive maintenance activities get done in order to minimize the completion time of all products (makespan. A mathematical modeling is presented and its validation is shown by solving an example in small scale. Since this problem has been proved strongly NP-hard, in order to solve the problem in medium and large scale, four heuristic algorithms is proposed based on the Johnson’s algorithm. The numerical experiments are used to run the mathematical model and evaluate the performance of the proposed algorithms.

Persuasive Normative Messages: The Influence of Injunctive and Personal Norms on Using Free Plastic Bags

OpenAIRE

Judith I.M. de Groot; Wokje Abrahamse; Kayleigh Jones

2013-01-01

In this exploratory field-study, we examined how normative messages ( i.e. , activating an injunctive norm, personal norm, or both) could encourage shoppers to use fewer free plastic bags for their shopping in addition to the supermarket’s standard environmental message aimed at reducing plastic bags. In a one-way subjects-design ( N = 200) at a local supermarket, we showed that shoppers used significantly fewer free plastic bags in the injunctive, personal and combined normative message cond...

Two cases of death due to plastic bag suffocation.

Science.gov (United States)

Nadesan, K; Beng, O B

2001-01-01

Deaths due to plastic bag suffocation or plastic bag asphyxia are not reported in Malaysia. In the West many suicides by plastic bag asphyxia, particularly in the elderly and those who are chronically and terminally ill, have been reported. Accidental deaths too are not uncommon in the West, both among small children who play with shopping bags and adolescents who are solvent abusers. Another well-known but not so common form of accidental death from plastic bag asphyxia is sexual asphyxia, which is mostly seen among adult males. Homicide by plastic bag asphyxia too is reported in the West and the victims are invariably infants or adults who are frail or terminally ill and who cannot struggle. Two deaths due to plastic bag asphyxia are presented. Both the autopsies were performed at the University Hospital Mortuary, Kuala Lumpur. Both victims were 50-year old married Chinese males. One death was diagnosed as suicide and the other as sexual asphyxia. Sexual asphyxia is generally believed to be a problem associated exclusively with the West. Specific autopsy findings are often absent in deaths due to plastic bag asphyxia and therefore such deaths could be missed when some interested parties have altered the scene and most importantly have removed the plastic bag. A visit to the scene of death is invariably useful.

Typically Female Features in Hungarian Shopping Tourism

Directory of Open Access Journals (Sweden)

Gábor Michalkó

2006-06-01

Full Text Available Although shopping has been long acknowledged as a major tourist activity, the extent and characteristics of shopping tourism have only recently become the subject of academic research and discussion. As a contribution to this field of knowledge, the paper presents the characteristics of shopping tourism in Hungary, and discusses the typically female features of outbound Hungarian shopping tourism. The research is based on a survey of 2473 Hungarian tourists carried out in 2005. As the findings of the study indicate, while female respondents were altogether more likely to be involved in tourist shopping than male travellers, no significant difference was experienced between the genders concerning the share of shopping expenses compared to their total travel budget. In their shopping behaviour, women were typically affected by price levels, and they proved to be both more selfish and more altruistic than men by purchasing more products for themselves and for their family members. The most significant differences between men and women were found in their product preferences as female tourists were more likely to purchase typically feminine goods such as clothes, shoes, bags and accessories, in the timing of shopping activities while abroad, and in the information sources used by tourists, since interpersonal influences such as friends’, guides’ and fellow travellers’ recommendations played a higher role in female travellers’ decisions.

The Portuguese plastic carrier bag tax: The effects on consumers' behavior.

Science.gov (United States)

Martinho, Graça; Balaia, Natacha; Pires, Ana

2017-03-01

Marine litter from lightweight plastic bags is a global problem that must be solved. A plastic bag tax was implemented in February 2015 to reduce the consumption of plastic grocery bags in Portugal and in turn reduce the potential contribution to marine litter. This study analyzes the effect of the plastic bag tax on consumer behavior to learn how it was received and determine the perceived effectiveness of the tax 4months after its implementation. In addition, the study assessed how proximity to coastal areas could influence behaviors and opinions. The results showed a 74% reduction of plastic bag consumption with a simultaneously 61% increase of reusable plastic bags after the tax was implemented. Because plastic bags were then reused for shopping instead of garbage bags, however, the consumption of garbage bags increased by 12%. Although reduction was achieved, the tax had no effect on the perception of marine litter or the impact of plastic bags on environment and health. The majority of respondents agree with the tax but view it as an extra revenue to the State. The distance to the coast had no meaningful influence on consumer behavior or on the perception of the tax. Although the tax was able to promote the reduction of plastics, the role of hypermarkets and supermarkets in providing alternatives through the distribution of reusable plastic bags was determinant to ensuring the reduction. Copyright © 2017 Elsevier Ltd. All rights reserved.

Flexible job shop scheduling problem in manufacturing

OpenAIRE

Curralo, Ana; Pereira, Ana I.; Barbosa, José; Leitão, Paulo

2013-01-01

This paper addresses a real assembly cell: the AIP-PRIMECA cell at the Université de Valenciennes et du Hainaut-Cambrésis, in France. This system can be viewed as a Flexible Job Shop, leading to the formulation of a Flexible Job Shop Scheduling Problem (FJSSP).

Green Purchasing Behavior Analysis of Government Policy About Paid Plastic Bags

Directory of Open Access Journals (Sweden)

Muhammad Khoiruman

2017-06-01

Full Text Available This research will be conducted to know: 1 The influence of green perceived value to consumer green trust to use plastic bag after the policy of using plastic bag paid at modern retail store in Surakarta. 2 The influence of green perceived risk to consumer green trust to use plastic bag after the policy of using plastic bag paid at modern retail store in Surakarta. 3 The effect of green trust on green purchase behavior of consumers to use plastic bags after the policy of using plastic bag paid at modern retail store in Surakarta. The study was conducted in modern retail stores (Alfamart, Indomart and Superindo in Surakarta using 200 respondents who shop at the modern retail store. A model that can be used to measure green purchasing behavior in the use of paid plastic bags using four interrelated variables: green perceived value, green perceived risk, green trust and green purchasing. Data analysis using Structural Equation Model (SEM. The result of analysis and discussion showed that green perceived value have positive and significant effect to green trust, green trust has positive effect on green purchasing, but green perceived risk has no significant effect to green trust.

Innovation prize for air-conditioned assembly shop - Constant temperature allows the assembly of high-precision machining centres; Innovationspreis fuer klimatisierte Montagehalle

Energy Technology Data Exchange (ETDEWEB)

Schmid, W.

2002-07-01

This article describes the clever combination of various techniques to achieve the goal of providing a stable ambient temperature with an accuracy of +/- 1 K in the assembly shop of a German manufacturer of precision machine tools. The requirements placed on the assembly and operation of machine tools operating to an accuracy of less that a hundredth of a millimetre are discussed. The award-winning heating and cooling system, which features the use of gravity cooling, geothermal energy (ground water for cooling) and the use of constructional elements (floor, facades, windows) for thermal buffering is described. The ingenious control system with 32 control zones and 64 sensors is described, which also provides the company's management with long-term documentation of temperature conditions for quality assurance purposes. Technical data on the installation is provided in table form.

Solar saddle bags. Solar-Fahrradpacktaschen

Energy Technology Data Exchange (ETDEWEB)

Willems, M

1991-09-12

The invention consists of the arrangement of solar cells on the upper side of saddle bags of every design (handle bar pocket, bicycle saddle bag etc.) which charge the accumulators in the pack pocket. One can drive the alternator of the bicycle, a transistor radio, a cassette tape recorder, or similar, with the power from the accumulators. The lamp and the taillight of the bicycle can still be used. The solar cells can be attached firmly to the pack pocket. However, they can also be assembled detachably, e.g. by push-buttons or zip-fasteners.

Welding facilities for NPP assembling

International Nuclear Information System (INIS)

Rojtenberg, S.S.

1987-01-01

Recommendations concerning the choice of equipment for welding in pre-assembling work shops, in the enlarging assembling shops and at the assembling site, are given. Advanced production automatic welders and semiautomatic machines, applied during the NPP equipment assembling as well as automatic machines specially produced for welding the main reactor components and pipelines are described. Automatic and semiautomatic machine and manual welding post supply sources are considered

Usage of Plastic Bags and Health Hazards: A Study to Assess Awareness Level and Perception about Legislation Among a Small Population of Mangalore City.

Science.gov (United States)

Joseph, Nitin; Kumar, Aswin; Majgi, Sumanth Mallikarjuna; Kumar, Ganesh S; Prahalad, Raghavendra Babu Yellapur

2016-04-01

Plastic bag users are at risk of number of health hazards. There is paucity of data with regard to awareness of health hazards among general population in India. This study was done to find out the status of awareness of the health hazards associated with the usage of plastic bags among people and their perception towards the legislation prohibiting the usage of plastic bags. This cross-sectional study conducted in Mangalore city in August 2013. Data was collected by interviewing any adult member (aged above 18 years) in each of the selected households using an interview schedule. Mean age of the 250 participants was 32.8±10.8 years. Majority 160(64%) were females educated up to undergraduate level or above 187(74.8%). Among the participants 216(86.4%) were aware of the health hazards associated with the use of plastic bags. Awareness was significantly more amongst females (p=0.027), well-educated participants (p=0.004) and among professionals and semi-professionals (pplastic bags for shopping after initial usage. The cloth bags were used for shopping in place of plastic bags by 13(5.2%) participants. Among the participants 213(85.2%) were aware of the legislation banning the use of plastic bags and out of which 166(77.9%) were in its favour. Semi-professionals and students favoured the ban on plastic bags whereas unskilled and semiskilled workers were against the ban (p=0.01). Most of the participants in the settings had the awareness of hazards of plastic bag usage. However, there is a need for spreading the awareness of using alternative strategies and effective implementation of legislation in order to minimize the usage of plastics in the community.

Usage of Plastic Bags and Health Hazards: A Study to Assess Awareness Level and Perception about Legislation Among a Small Population of Mangalore City

Science.gov (United States)

Kumar, Aswin; Majgi, Sumanth Mallikarjuna; Kumar, Ganesh S; Prahalad, Raghavendra Babu Yellapur

2016-01-01

Introduction Plastic bag users are at risk of number of health hazards. There is paucity of data with regard to awareness of health hazards among general population in India. Aim This study was done to find out the status of awareness of the health hazards associated with the usage of plastic bags among people and their perception towards the legislation prohibiting the usage of plastic bags. Materials and Methods This cross-sectional study conducted in Mangalore city in August 2013. Data was collected by interviewing any adult member (aged above 18 years) in each of the selected households using an interview schedule. Results Mean age of the 250 participants was 32.8±10.8 years. Majority 160(64%) were females educated up to undergraduate level or above 187(74.8%). Among the participants 216(86.4%) were aware of the health hazards associated with the use of plastic bags. Awareness was significantly more amongst females (p=0.027), well-educated participants (p=0.004) and among professionals and semi-professionals (pplastic bags for shopping after initial usage. The cloth bags were used for shopping in place of plastic bags by 13(5.2%) participants. Among the participants 213(85.2%) were aware of the legislation banning the use of plastic bags and out of which 166(77.9%) were in its favour. Semi-professionals and students favoured the ban on plastic bags whereas unskilled and semiskilled workers were against the ban (p=0.01). Conclusion Most of the participants in the settings had the awareness of hazards of plastic bag usage. However, there is a need for spreading the awareness of using alternative strategies and effective implementation of legislation in order to minimize the usage of plastics in the community. PMID:27190841

Using nudges to reduce waste? The case of Toronto's plastic bag levy.

Science.gov (United States)

Rivers, Nicholas; Shenstone-Harris, Sarah; Young, Nathan

2017-03-01

The overuse of disposable plastic bags is a major environmental problem across the globe. In recent years, numerous jurisdictions have sought to curb disposable bag use by implementing a levy or fee at the point of purchase. These levies are typically small and symbolic (around $0.05 per bag), but serve as a highly-visible and continuous reminder to consumers. As such, they are consistent with nudging policies that seek to encourage broad changes in behaviour through small, non-coercive measures that influence people's thinking about an issue. While existing empirical evidence suggests that nudges are highly effective in reducing disposable bag use, we argue that many of these studies are flawed because they lack adequate temporal and geographic controls. We use longitudinal data from four waves of a major Canadian survey to analyze the effect of a disposable bag levy in the City of Toronto. Controlling for demographics and changes in social norms over time, we find that the levy increased the use of reusable shopping bags by 3.4 percentage points. Moreover, we find that the impact of the policy was highly variable across behavioural and demographic groups. The levy was highly effective in encouraging people who already used reusable bags to use them more frequently, while having no effect on infrequent users. We also find that the effects are limited to households with high socio-economic status (as measured by income, educational attainment, and housing situation). This suggests important limitations for nudging policy more generally, as people with lower socio-economic status appear to have been unaffected by this behavioural prompt. Copyright © 2016 Elsevier Ltd. All rights reserved.

Double Vacuum Bag Process for Resin Matrix Composite Manufacturing

Science.gov (United States)

Hou, Tan-Hung (Inventor); Jensen, Brian J. (Inventor)

2007-01-01

A double vacuum bag molding assembly with improved void management and laminate net shape control which provides a double vacuum enviromnent for use in fabricating composites from prepregs containing air and/or volatiles such as reactive resin matrix composites or composites from solvent containing prepregs with non-reactive resins matrices. By using two vacuum environments during the curing process, a vacuum can be drawn during a B-stage of a two-step cycle without placing the composite under significant relative pressure. During the final cure stage, a significant pressure can be applied by releasing the vacuum in one of the two environments. Inner and outer bags are useful for creating the two vacuum environments with a perforated tool intermediate the two. The composite is placed intermediate a tool plate and a caul plate in the first environment with the inner bag and tool plate defining the first environment. The second environment is characterized by the outer bag which is placed over the inner bag and the tool plate.

Astronomy in my shopping cart: Today I bought some asteroids, hundreds of black holes and three Solar Systems!

Science.gov (United States)

Boccato, C.; Lazzaretto, E.

2008-06-01

Here we will present a pilot project that will be tested and developed throughout 2007/08 in advance of the International Year of Astronomy. Why "putting astronomy in the shopping cart"? The aim of the project is to publicise astrophysics at a popular level, choosing a place that best matches the meaning of the word `popular': the shopping mall. With this project we want to arouse consumer interest in science, making use of the supermarket inside any shopping mall: a place people are familiar with and where they find common consumer goods. The final purpose is to give our science consumer the chance to bring home shopping bags filled not only with consumer goods, but also with a piece of knowledge about astronomy, astrophysics and the way astronomers work and think to understand the Universe and its phenomena.

Potential bags

International Nuclear Information System (INIS)

Ferreira, P.L.; Tomio, L.

1992-01-01

In this paper, relativistic confining potential models, endowed with bag constants associated to volume energy terms, are investigated. In contrast to the usual bag model, these potential bags are distinguished by having smeared bag surfaces. Based on the dynamical assumptions underlying the fuzzy bag model, these bag constants are derived from the corresponding energy-momentum tensor. Explicit expressions for the single-quark energies and for the nucleon bag constant are obtained by means of an improved analytical version of the saddle-point variational method for the Dirac equation with confining power-law potentials of the scalar plus vector (S + V) or pure scalar (S) type

Breaking BAG: The Co-Chaperone BAG3 in Health and Disease.

Science.gov (United States)

Behl, Christian

2016-08-01

Human BAG (Bcl-2-associated athanogene) proteins form a family of antiapoptotic proteins that currently consists of six members (BAG1-6) all sharing the BAG protein domain from which the name arises. Via this domain, BAG proteins bind to the heat shock protein 70 (Hsp70), thereby acting as a co-chaperone regulating the activity of Hsp70. In addition to their antiapoptotic activity, all human BAG proteins have distinct functions in health and disease, and BAG3 in particular is the focus of many investigations. BAG3 has a modular protein domain composition offering the possibility for manifold interactions with other proteins. Various BAG3 functions are implicated in disorders including cancer, myopathies, and neurodegeneration. The discovery of its role in selective autophagy and the description of BAG3-mediated selective macroautophagy as an adaptive mechanism to maintain cellular homeostasis, under stress as well as during aging, make BAG3 a highly interesting target for future pharmacological interventions. Copyright © 2016 Elsevier Ltd. All rights reserved.

Urine drainage bags

Science.gov (United States)

Leg bag ... the catheter from your bladder into the leg bag. Your leg bag will be attached to you all day. You ... freely with it. You can hide your leg bag under skirts, dresses, or pants. They come in ...

Science Shops

DEFF Research Database (Denmark)

Jørgensen, Michael Søgaard

1999-01-01

The paper prsents the overall concept of science shops as practised in most of the European science shops and present the concept practised and some experience obtained at the Technical University of Denmark. An outline for the planning of new sceince shops is presented.......The paper prsents the overall concept of science shops as practised in most of the European science shops and present the concept practised and some experience obtained at the Technical University of Denmark. An outline for the planning of new sceince shops is presented....

Eyes Wide Shopped: Shopping Situations Trigger Arousal in Impulsive Buyers

Science.gov (United States)

Serfas, Benjamin G.; Büttner, Oliver B.; Florack, Arnd

2014-01-01

The present study proposes arousal as an important mechanism driving buying impulsiveness. We examined the effect of buying impulsiveness on arousal in non-shopping and shopping contexts. In an eye-tracking experiment, we measured pupil dilation while participants viewed and rated pictures of shopping scenes and non-shopping scenes. The results demonstrated that buying impulsiveness is closely associated with arousal as response to viewing pictures of shopping scenes. This pertained for hedonic shopping situations as well as for utilitarian shopping situations. Importantly, the effect did not emerge for non-shopping scenes. Furthermore, we demonstrated that arousal of impulsive buyers is independent from cognitive evaluation of scenes in the pictures. PMID:25489955

Eyes wide shopped: shopping situations trigger arousal in impulsive buyers.

Science.gov (United States)

Serfas, Benjamin G; Büttner, Oliver B; Florack, Arnd

2014-01-01

The present study proposes arousal as an important mechanism driving buying impulsiveness. We examined the effect of buying impulsiveness on arousal in non-shopping and shopping contexts. In an eye-tracking experiment, we measured pupil dilation while participants viewed and rated pictures of shopping scenes and non-shopping scenes. The results demonstrated that buying impulsiveness is closely associated with arousal as response to viewing pictures of shopping scenes. This pertained for hedonic shopping situations as well as for utilitarian shopping situations. Importantly, the effect did not emerge for non-shopping scenes. Furthermore, we demonstrated that arousal of impulsive buyers is independent from cognitive evaluation of scenes in the pictures.

Eyes wide shopped: shopping situations trigger arousal in impulsive buyers.

Directory of Open Access Journals (Sweden)

Benjamin G Serfas

Full Text Available The present study proposes arousal as an important mechanism driving buying impulsiveness. We examined the effect of buying impulsiveness on arousal in non-shopping and shopping contexts. In an eye-tracking experiment, we measured pupil dilation while participants viewed and rated pictures of shopping scenes and non-shopping scenes. The results demonstrated that buying impulsiveness is closely associated with arousal as response to viewing pictures of shopping scenes. This pertained for hedonic shopping situations as well as for utilitarian shopping situations. Importantly, the effect did not emerge for non-shopping scenes. Furthermore, we demonstrated that arousal of impulsive buyers is independent from cognitive evaluation of scenes in the pictures.

Chiral bag model

International Nuclear Information System (INIS)

Musakhanov, M.M.

1980-01-01

The chiral bag model is considered. It is suggested that pions interact only with the surface of a quark ''bag'' and do not penetrate inside. In the case of a large bag the pion field is rather weak and goes to the linearized chiral bag model. Within that model the baryon mass spectrum, β decay axial constant, magnetic moments of baryons, pion-baryon coupling constants and their form factors are calculated. It is shown that pion corrections to the calculations according to the chiral bag model is essential. The obtained results are found to be in a reasonable agreement with the experimental data

Enhancing Older People’s Outdoor Activities Through User-Centered (Shopping Bag Product Design; A Qualitative Study Based on the User-Centered Approach

Directory of Open Access Journals (Sweden)

Maliheh Naeimi

2015-07-01

Conclusion Considering the elderly's problems in shopping, a solution in product design is proposed to facilitate shopping and prevent difficulties such as forgetfulness. In future studies considering the anthropometrical measures to adjust the proposed solutions with the specific needs of users is suggested.

Laparoscopic specimen retrieval bags.

Science.gov (United States)

Smorgick, Noam

2014-10-01

Specimen retrieval bags have long been used in laparoscopic gynecologic surgery for contained removal of adnexal cysts and masses. More recently, the concerns regarding spread of malignant cells during mechanical morcellation of myoma have led to an additional use of specimen retrieval bags for contained "in-bag" morcellation. This review will discuss the indications for use retrieval bags in gynecologic endoscopy, and describe the different specimen bags available to date.

Bags Under Eyes

Science.gov (United States)

Bags under eyes Overview Bags under eyes — mild swelling or puffiness under the eyes — are common as you age. With aging, the tissues around your ... space below your eyes, adding to the swelling. Bags under eyes are usually a cosmetic concern and ...

Gold-decorated shopping centre; Golddekoriertes Shopping Center

Energy Technology Data Exchange (ETDEWEB)

Altmannshofer, Robert

2010-11-15

In the autumn 2009, the German quality seal sustainable construction for commercial new buildings was introduced. Thus, owners and operators of retail real estate and shopping centres can make clear their commitment in the matter of sustainability. The Ernst-August-Galerie (Hanover, Federal Republic of Germany) developed and operated by ECE Projektmanagement GmbH and Co. KG (Hamburg, Federal Republic of Germany) was a pilot project and also the first gold in one. With its around 150 shops, the Ernst-August-Galerie offers a supermarket, fashion outlets, a food court, service outlets and restaurants/cafes. The spacious and elegantly designed shopping mall with its piazzas and light-flooded rotundas exudes a Mediterranean air, making it a high-quality venue for shopping, strolling and leisure activities.

Examination of Energy Efficiency Increasing Measures in an Automobile Assembly Plant

Directory of Open Access Journals (Sweden)

Fatma ÇANKA KILIÇ

2018-03-01

Full Text Available In this study, energy consumption analysis was performed in a car assembly plant (Body-inWhite (BiW productions, painting processes, chassis and accessory assembly processes. Examined automobile assembly plant has a production capacity of 200,000 vehicles per year by working six days a week and three shifts a day. Highly energy consuming processes are determined. Energy efficiency increasing opportunities in energy consuming systems (paint shop, drying ovens, compressed air, heating and cooling systems and effects of current automotive assembly techniques on energy efficiency are examined. Most of the total energy in the studied plant is consumed in the paint shop. Considering annual energy consumption; paint shop is responsible for the %50 of total electrical energy and %70 of total natural gas consumption. Specific energy consumption of plant is calculated as 853 kWh (SET; 275 kWh for electricity consumption (SETe , and 578 kWh for natural gas (SETdg . By performing determined energy efficiency measures; SET of plant will reduce %1 for the SETe , and %5,7 for SETdg

Comparison Shopping Agents and Czech Online Customers’ Shopping Behaviour

Directory of Open Access Journals (Sweden)

Pilik Michal

2016-12-01

Full Text Available The internet has changed the lifestyles and shopping behaviours of customers. Online purchasing enables people to obtain information about products and services provided more effectively and easily, with the result that home shopping has become ordinary and usual. This paper presents part of a research focusing on online shopping customers’ behaviour in the Czech Republic. The article pertains to comparison shopping agents (CPAs, a tool which provides information to customers and helps find the best offer. The research was conducted on the basis of an online questionnaire available on an internet web page. The main results confirmed a dependency between online purchasing and the use of shopping agents, which are very popular in the Czech Republic. Almost two-thirds of online shoppers use CPAs when they engage in internet shopping. The final part of the paper addresses references and customers’ reviews as an important factor for the selection of online retailer.

Shopping Centres and Selected Aspects of Shopping Behaviour (Brno, the Czech Republic)

Czech Academy of Sciences Publication Activity Database

Kunc, J.; Tonev, P.; Szczyrba, Z.; Frantál, Bohumil

2012-01-01

Roč. 7, č. 2 (2012), s. 39-51 ISSN 2065-4421 Institutional support: RVO:68145535 Keywords : shopping centres * shopping habits * commuting to retail shops Subject RIV: AO - Sociology, Demography http://technicalgeography.org/pdf/2_2012/05_josef_kunc_petr_tonev_zdenek_szczyrba_bohumil_frantal_shopping_centres_and_selected_aspects_of_shopping_behaviour.pdf

The fuzzy bag model revisited

International Nuclear Information System (INIS)

Pilotto, F.; Vasconcellos, C.A.Z.; Coelho, H.T.

2001-01-01

In this work we develop a new version of the fuzzy bag model. Th main ideas is to include the conservation of energy and momentum in the model. This feature is not included in the original formulation of the fuzzy bag model, but is of paramount importance to interpret the model as being a bag model - that, is a model in which the outward pressure of the quarks inside the bag is balanced by the inward pressure of the non-perturbative vacuum outside the bag - as opposed to a relativistic potential model, in which there is no energy-momentum conservation. In the MT bag model, as well as in the original version of the fuzzy bag model, the non-perturbative QCD vacuum is parametrized by a constant B in the Lagrangian density. One immediate consequence of including energy-momentum conservation in the fuzzy bag model is that the bag constant B will acquire a radial dependence, B = B(r). (author)

The fuzzy bag model revisited

Energy Technology Data Exchange (ETDEWEB)

Pilotto, F.; Vasconcellos, C.A.Z. [Rio Grande do Sul Univ., Porto Alegre, RS (Brazil). Inst. de Fisica; Coelho, H.T. [Pernambuco Univ., Recife, PE (Brazil). Inst. de Fisica

2001-07-01

In this work we develop a new version of the fuzzy bag model. Th main ideas is to include the conservation of energy and momentum in the model. This feature is not included in the original formulation of the fuzzy bag model, but is of paramount importance to interpret the model as being a bag model - that, is a model in which the outward pressure of the quarks inside the bag is balanced by the inward pressure of the non-perturbative vacuum outside the bag - as opposed to a relativistic potential model, in which there is no energy-momentum conservation. In the MT bag model, as well as in the original version of the fuzzy bag model, the non-perturbative QCD vacuum is parametrized by a constant B in the Lagrangian density. One immediate consequence of including energy-momentum conservation in the fuzzy bag model is that the bag constant B will acquire a radial dependence, B = B(r). (author)

Dynamical chiral bag model

International Nuclear Information System (INIS)

Colanero, K.; Chu, M.-C.

2002-01-01

We study a dynamical chiral bag model, in which massless fermions are confined within an impenetrable but movable bag coupled to meson fields. The self-consistent motion of the bag is obtained by solving the equations of motion exactly assuming spherical symmetry. When the bag interacts with an external meson wave we find three different kinds of resonances: fermionic, geometric, and σ resonances. We discuss the phenomenological implications of our results

7 CFR 201.41 - Bags.

Science.gov (United States)

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false Bags. 201.41 Section 201.41 Agriculture Regulations of... Sampling in the Administration of the Act § 201.41 Bags. (a) For lots of six bags or less, each bag shall be sampled. A total of at least five trierfuls shall be taken. (b) For lots of more than six bags...

Rules for Adaptive Learning and Assistance on the Shop Floor

Science.gov (United States)

Ullrich, Carsten

2016-01-01

Today's shop floor, the area of a factory where operatives assemble products, is a complex and demanding work environment. The employed and produced technology becomes ever more complex, and employees are responsible for an increasing amount of tasks. As a consequence, the employee is under constant pressure to solve problems occurring on the shop…

Soumen Bag

Indian Academy of Sciences (India)

Home; Journals; Sadhana. Soumen Bag. Articles written in Sadhana. Volume 38 Issue 1 February 2013 pp 133-168. A survey on optical character recognition for Bangla and Devanagari scripts · Soumen Bag Gaurav Harit · More Details Abstract Fulltext PDF. The past few decades have witnessed an intensive research on ...

The Chiral bag model and the little bag

International Nuclear Information System (INIS)

Vento, Vincent.

1980-11-01

We review the properties of the existing solutions to the Chiral bag equations of motion and discuss how the 'little bag' picture could come about in this scheme. Our analysis leads to a model which is qualitatively similar to the naive quark model with pion cloud corrections. We use this latter approach to look for pion cloud signatures in experimental data

ShopComm: Community-Supported Online Shopping for Older Adults.

Science.gov (United States)

Gorkovenko, Katerina; Tigwell, Garreth W; Norrie, Christopher S; Waite, Miriam; Herron, Daniel

2017-01-01

The United Kingdom has an ageing population whose members experience significant life transitions as they grow older, for example, losing mobility due to deteriorating health. For these adults, digital technology has the potential to sustain their independence and improve their quality of life. However older adults can be reluctant to use digital solutions. In this paper, we review a local charity providing a grocery shopping service for older adults who are unable to go themselves. We explore how older adults perceive the benefits and drawbacks of both physical and digital shopping. Using these insights, we designed ShopComm to enable and support older adults with mobility impairments to shop online.

Bag facaden

DEFF Research Database (Denmark)

Hvidtfeldt, Susanne; Sjøstedt, Lotte Ebsen

Bag facaden er et task-baseret materiale der går bag om danskerne kulturelt og sprogligt. Det henvender sig til spor 3-learnere på de sidste trin, men kan i nogle klasser godt anvendes tidligere. Teksterne i bogen er autentiske dagbogsnotater skrevet af danskere i alle aldre. Den nærværende og...... eller hun er i sin sprogtilegnelse og i sit behov for viden om dansk kultur og samfund. Derudover forbereder det fint learneren til almenprøve 2 og DUF eksamen, både hvad angår indhold og arbejdsformer. I forløb hvor der stiles mod folkeskolens afgangseksamner er Bag facaden relevant som supplerende...

Vector-Interaction-Enhanced Bag Model

Science.gov (United States)

Cierniak, Mateusz; Klähn, Thomas; Fischer, Tobias; Bastian, Niels-Uwe

2018-02-01

A commonly applied quark matter model in astrophysics is the thermodynamic bag model (tdBAG). The original MIT bag model approximates the effect of quark confinement, but does not explicitly account for the breaking of chiral symmetry, an important property of Quantum Chromodynamics (QCD). It further ignores vector repulsion. The vector-interaction-enhanced bag model (vBag) improves the tdBAG approach by accounting for both dynamical chiral symmetry breaking and repulsive vector interactions. The latter is of particular importance to studies of dense matter in beta-equilibriumto explain the two solar mass maximum mass constraint for neutron stars. The model is motivated by analyses of QCD based Dyson-Schwinger equations (DSE), assuming a simple quark-quark contact interaction. Here, we focus on the study of hybrid neutron star properties resulting from the application of vBag and will discuss possible extensions.

Omni channel fashion shopping

NARCIS (Netherlands)

Kemperman, A.D.A.M.; van Delft, L.; Borgers, A.W.J.; Pantano, E.

2015-01-01

This chapter gives insight into consumers' online and offline fashion shopping behavior, consumers' omni-channel usage during the shopping process, and consumer fashion shopper segments. Based on a literature review, omni-channel shopping behavior during the shopping process was operationalized.

Manufacturing requirements of reactor assembly components for PFBR (Paper No. 041)

International Nuclear Information System (INIS)

Murty, C.G.K.; Bhoje, S.B.

1987-02-01

This paper enumerates the requirements of 500 MWe Prototype Fast Breeder Reactor (PFBR) components and considering the present state of art of Indian industry an analysis is made on the challenges to be faced in manufacture highlighting the areas needing development. The large sizes and weights of the components coupled with the limitations on shop facilities and ODC transport, demand part of the fabrication to be done at shop and balance assembly work as well as certain assembly machining operations to be done at site work shop. The stringent geometrical tolerances coupled with extensive destructive and non-destructive examinations call for balanced and low heat input welding techniques and special inspection equipment like electronic co-ordinate determination system. The present paper deals with the specific manufacturing problems of the main reactor components. (author)

ATTITUDES TOWARD ONLINE SHOPPING FROM THE ASPECTS OF PERSONAL CHARACTERISTICS AND SHOPPING MOTIVE THROUGH A DEVELOPING CONCEPT: PRIVATE SHOPPING

OpenAIRE

BAYBARS, Miray; USTUNDAGLI, Elif

2011-01-01

Private shopping is one of the concepts that serve as a members-only online shopping platform with deep discounts and well-known brands. The aim of this paper is to determine whether consumers’ need for uniqueness and innovativeness as a personal trait and price discount orientation affect consumer attitudes toward private shopping and their purchase decision or not. Research results revealed that need for uniqueness and innovativeness affect positive attitudes towards private shopping positi...

Bag model with diffuse surface

International Nuclear Information System (INIS)

Phatak, S.C.

1986-01-01

The constraint of a sharp bag boundary in the bag model is relaxed in the present work. This has been achieved by replacing the square-well potential of the bag model by a smooth scalar potential and introducing a term similar to the bag pressure term. The constraint of the conservation of the energy-momentum tensor is used to obtain an expression for the added bag pressure term. The model is then used to determine the static properties of the nucleon. The calculation shows that the rms charge radius and the nucleon magnetic moment are larger than the corresponding bag model values. Also, the axial vector coupling constant and the πNN coupling constant are in better agreement with the experimental values

Supporting the Supermarket Shopping Experience through a Context-Aware Shopping Trolley

DEFF Research Database (Denmark)

Black, Darren; Clemmensen, Nils Jakob; Skov, Mikael B.

2009-01-01

Shopping in the real world is becoming an increasingly interactive experience as stores integrate various technologies to support shoppers. Based on an empirical study of supermarket shoppers, we designed a mobile context-aware system called the Context- Aware Shopping Trolley (CAST). The aim...... of the system is to support shopping in supermarkets through context-awareness and acquiring user attention. Thus, the interactive trolley guides and directs shoppers in the handling and finding of groceries. An empirical evaluation showed that shoppers using CAST adapted in different shopping behavior than...... traditional trolley shoppers by exhibiting a more uniform behavior in terms of product sequence collection and ease of finding products and thus, CAST supported the shopping experience....

Shopping online and/or in-store? A structural equation model of the relationships between e-shopping and in-store shopping

OpenAIRE

Farag, Sendy; Schwanen, Tim; Dijst, Martin

2005-01-01

Searching product information or buying goods online is becoming increasingly popular and could affect shopping trips. However, the relationship between e-shopping and in-store shopping is currently unclear. The aim of this study is to investigate empirically how the frequencies of online searching, online buying, and non-daily shopping trips relate to each other, after controlling for sociodemographic, land use, behavioral, and attitudinal characteristics. Data were collected from 826 respon...

Performance testing of the new AMPAC fire debris bag against three other commercial fire debris bags.

Science.gov (United States)

Grutters, Michiel M P; Dogger, Judith; Hendrikse, Jeanet N

2012-09-01

Fire debris evidence is collected and stored in a wide range of containers, including various polymer bags. Four different polymer bags have been investigated, including the NYLON, DUO, ALU, and AMPAC bags. The latter is the successor of the Kapak Fire DebrisPAK™. Microscopy and infrared spectroscopy were used to elucidate the composition of the bags. Gas chromatography/mass spectrometry was used to investigate performance parameters such as background volatiles, leak rate, cross-contamination, recovery, and sorption. The NYLON bag was susceptible for leakage and cross-contamination and showed decreased recoveries. The DUO and ALU bags showed some background volatiles, sorption, and poor recoveries. The AMPAC bag performed excellent: low background, no leakage or cross-contamination, good recoveries, and only traces of sorption. Heat sealing proved to be the best method of closure. Preliminary studies on AMPAC bags showed that polyethylene clamps are easy to use on-site and preserve ignitable liquids adequately for a limited period of time. © 2012 American Academy of Forensic Sciences.

Dynamics of the soliton bag

International Nuclear Information System (INIS)

Wilets, L.; Goldflam, R.

1983-09-01

The MIT bag was one of the earliest and most successful models of QCD, imposing confinement and including perturbative gluon interactions. An evolution of the MIT bag came with the introduction of the chiral and cloudy bags, which treat pions as elementary particles. As a model of QCD, the soliton model proposed by Friedberg and Lee is particularly attractive. It is based on a covariant field theory and is sufficiently general so that, for certain limiting cases of the adjustable parameters, it can describe either the MIT or SLAC (string) bags. The confinement mechanism appears as a dynamic field. This allows non-static processes, such as bag oscillations and bag collisions, to be calculated utilizing the well-developed techniques of nuclear many-body theory. The utilization of the model for calculating dynamical processes is discussed. 14 references

Minimizing the Makespan for a Two-Stage Three-Machine Assembly Flow Shop Problem with the Sum-of-Processing-Time Based Learning Effect

Directory of Open Access Journals (Sweden)

Win-Chin Lin

2018-01-01

Full Text Available Two-stage production process and its applications appear in many production environments. Job processing times are usually assumed to be constant throughout the process. In fact, the learning effect accrued from repetitive work experiences, which leads to the reduction of actual job processing times, indeed exists in many production environments. However, the issue of learning effect is rarely addressed in solving a two-stage assembly scheduling problem. Motivated by this observation, the author studies a two-stage three-machine assembly flow shop problem with a learning effect based on sum of the processing times of already processed jobs to minimize the makespan criterion. Because this problem is proved to be NP-hard, a branch-and-bound method embedded with some developed dominance propositions and a lower bound is employed to search for optimal solutions. A cloud theory-based simulated annealing (CSA algorithm and an iterated greedy (IG algorithm with four different local search methods are used to find near-optimal solutions for small and large number of jobs. The performances of adopted algorithms are subsequently compared through computational experiments and nonparametric statistical analyses, including the Kruskal–Wallis test and a multiple comparison procedure.

Internet Shopping

Institute of Scientific and Technical Information of China (English)

刘洪毓

2004-01-01

Nowadays you no longer need to walk round hundreds of shops looking for the items you need. You can shop for just about anything from your armchair. All you need is a computer and access(进入) to the Internet.

THE INFLUENCE OF HEDONIC SHOPPING MOTIVATION TO THE IMPULSE BUYING OF ONLINE-SHOPPING CONSUMER ON INSTAGRAM

Directory of Open Access Journals (Sweden)

Asnawati

2018-02-01

Full Text Available This research aims to know the influence of Adventure Shopping, Relaxation Shopping, Value Shopping, Social Shopping and Idea Shopping variables to the variable of Impulse Buying of Online-Shopping Consumer on Instagram. The type of the research is explanatory research. The result of F-test showed that Fcount (12.829 > Ftable (2.669 which meant that research variables had influences to the Impulse Buying. With partial correlation value of 0.548, Idea Shopping variable became the dominant factor influencing Impulse Buying on the online-shopping purchase on Instagram.

BAG3 role in cardiomyocytes physiopathology

OpenAIRE

De Marco, Margot

2013-01-01

2010 - 2011 The anti-apoptotic protein BAG3 is expressed at high levels in skeletal and cardiac muscle in vivo. Our group recently focused its interest on BAG3 role in myocardiocyte proliferation, survival and response to stressful stimuli. We found that BAG3 is upregulated during the differentiation of cardiomyoblasts. Our results prompted us to verify whether bag3 silencing could affect the differentiation state of cardiocytes and we found that bag3 silencing resulted in highly reducing ...

THE INFLUENCE OF HEDONIC SHOPPING MOTIVATION TO THE IMPULSE BUYING OF ONLINE-SHOPPING CONSUMER ON INSTAGRAM

OpenAIRE

Asnawati; Wahyuni S.

2018-01-01

This research aims to know the influence of Adventure Shopping, Relaxation Shopping, Value Shopping, Social Shopping and Idea Shopping variables to the variable of Impulse Buying of Online-Shopping Consumer on Instagram. The type of the research is explanatory research. The result of F-test showed that Fcount (12.829) > Ftable (2.669) which meant that research variables had influences to the Impulse Buying. With partial correlation value of 0.548, Idea Shopping variable became the dominant fa...

Analysis of a classical chiral bag model

International Nuclear Information System (INIS)

Nadeau, H.

1985-01-01

The author studies a classical chiral bag model with a Mexican hat-type potential for the self-coupling of the pion fields. He assumes a static spherical bag of radius R, the hedgehog ansatz for the chiral fields and that the quarks are all in the lowest lying s state. The author has considered three classes of models, the cloudy or pantopionic bags, the little or exopionic bags and the endopionic bags, where the pions are allowed all through space, only outside the bag and only inside the bag respectively. In all cases, the quarks are confined in the interior. He calculates the bag radius R, the bag constant B and the total ground state energy R for wide ranges of the two free parameters of the theory, namely the coupling constant λ and the quark frequency omega. The author focuses the study on the endopionic bags, the least known class, and compares the results with the familiar ones of other classes

Quantization of bag-like solitons

International Nuclear Information System (INIS)

Breit, J.D.

1982-01-01

The method of collective coordinates is used to quantize bag-like solitons formed by scalar and spinor fields. This method leads to approximate wave functions for quarks in the bag that are orthogonal to the translational modes. Solutions are given for the MIT bag limit of the fields. (orig.)

Shopping Malls - ShoppingCenters

Data.gov (United States)

NSGIC Local Govt | GIS Inventory — Collected from a variety of sources both commercial and internal, this layer represents shopping center locations within Volusia County and is maintained by the...

B P Bag

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. B P Bag. Articles written in Bulletin of Materials Science. Volume 35 Issue 1 February 2012 pp 1-5. Structural and optical characterization of thick and thin polycrystalline diamond films deposited by microwave plasma activated CVD · S K Pradhan B Satpati B P Bag T Sharda.

Storing Peanuts in Grain Bags

Science.gov (United States)

A study was executed to determine the potential of storing farmers stock peanuts and shelled peanuts for crushing in hermetically sealed grain bags. The objectives of the study were to evaluate equipment for loading and unloading the grain bags, the capacity of the grain bags, and the changes in qu...

A bag with soft surface

International Nuclear Information System (INIS)

Il-Tong Cheon.

1991-02-01

The MIT bag has a sharply edged surface. It seems to be unnatural. Taking vector mesons into account, we discuss effects of a smooth surface of the bag constructed by superposition of the MIT bags with various radii on the baryon magnetic moments. (author). 9 refs, 2 figs, 2 tabs

21 CFR 878.4100 - Organ bag.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Organ bag. 878.4100 Section 878.4100 Food and... GENERAL AND PLASTIC SURGERY DEVICES Surgical Devices § 878.4100 Organ bag. (a) Identification. An organ bag is a device that is a flexible plastic bag intended to be used as a temporary receptacle for an...

Female Consumers Recreational Shopping Experiences

Directory of Open Access Journals (Sweden)

Sarbjot Singh

2013-04-01

Full Text Available The study examines the core meaning of intrinsic shopping to understand their experimental aspects of recreational and leisure shopping. The study focus only on female shoppers of age group ranging from 25-30, and understand their mall experiences because this segment is newly transform into self dependent segment which have less social and familial liabilities and have enough enthusiasm to explore the world or their boundaries. The Grounded theory use for identification of recreational shopping themes which are (a seeking experiences and (b experimental shopping and each have respective sub themes. The themes are connected to the key idea that shoppers are motivated by their expectations and desires. The study uses social constructivism to find and understand the shopper meanings in real terms rather than imposing and judgment on them. The findings described the way people do recreational shopping and how shopping malls use as leisure space and become facilitators of recreational shopping activities. Females use malls to fulfill their recreational and leisure shopping experiences as this is the great way of enjoying shopping for females of small towns. In malls females not only enjoy product experiences but services experiences also which makes their shopping interesting. The way the female of this age category use malls help the marketers and retailers to understand this segment shopping patterns.

Swelling and infusion of tea in tea bags.

Science.gov (United States)

Yadav, Geeta U; Joshi, Bhushan S; Patwardhan, Ashwin W; Singh, Gurmeet

2017-07-01

The present study deals with swelling and infusion kinetics of tea granules in tea bags. The swelling and infusion kinetics of tea bags differing in tea loading and tea bag shapes were compared with loose tea. Increment in temperature and dipping frequency of tea bag in hot water increased the infusion kinetics of tea bags. Reduction in particle size enhanced the swelling and infusion kinetics of tea in a tea bag. The effects of tea particle size, tea bag dipping rate, loading of tea granules in tea bag and tea bag shapes on infusion kinetics were investigated. Increase in tea loading in tea bags resulted in reduced infusion kinetics. Double chambered tea bag showed the highest swelling (30%) and infusion kinetics (8.30% Gallic acid equivalence) while single chambered tea bags showed the lowest kinetics, amongst the various bags studied. The swelling and infusion kinetics of loose tea was always faster and higher than that of tea bags. It was found that overall effect of percentage filling of tea granules and height of tea bed in a tea bag affects tea infusion kinetics the most. Weibull model was found to be in good agreement with the swelling data.

Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress.

Science.gov (United States)

Liang, Jingjing; Sagum, Cari A; Bedford, Mark T; Sidhu, Sachdev S; Sudol, Marius; Han, Ziying; Harty, Ronald N

2017-01-01

Ebola (EBOV) and Marburg (MARV) viruses are members of the Filoviridae family which cause outbreaks of hemorrhagic fever. The filovirus VP40 matrix protein is essential for virus assembly and budding, and its PPxY L-domain motif interacts with WW-domains of specific host proteins, such as Nedd4 and ITCH, to facilitate the late stage of virus-cell separation. To identify additional WW-domain-bearing host proteins that interact with VP40, we used an EBOV PPxY-containing peptide to screen an array of 115 mammalian WW-domain-bearing proteins. Using this unbiased approach, we identified BCL2 Associated Athanogene 3 (BAG3), a member of the BAG family of molecular chaperone proteins, as a specific VP40 PPxY interactor. Here, we demonstrate that the WW-domain of BAG3 interacts with the PPxY motif of both EBOV and MARV VP40 and, unexpectedly, inhibits budding of both eVP40 and mVP40 virus-like particles (VLPs), as well as infectious VSV-EBOV recombinants. BAG3 is a stress induced protein that regulates cellular protein homeostasis and cell survival through chaperone-mediated autophagy (CMA). Interestingly, our results show that BAG3 alters the intracellular localization of VP40 by sequestering VP40 away from the plasma membrane. As BAG3 is the first WW-domain interactor identified that negatively regulates budding of VP40 VLPs and infectious virus, we propose that the chaperone-mediated autophagy function of BAG3 represents a specific host defense strategy to counteract the function of VP40 in promoting efficient egress and spread of virus particles.

Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress.

Directory of Open Access Journals (Sweden)

Jingjing Liang

2017-01-01

Full Text Available Ebola (EBOV and Marburg (MARV viruses are members of the Filoviridae family which cause outbreaks of hemorrhagic fever. The filovirus VP40 matrix protein is essential for virus assembly and budding, and its PPxY L-domain motif interacts with WW-domains of specific host proteins, such as Nedd4 and ITCH, to facilitate the late stage of virus-cell separation. To identify additional WW-domain-bearing host proteins that interact with VP40, we used an EBOV PPxY-containing peptide to screen an array of 115 mammalian WW-domain-bearing proteins. Using this unbiased approach, we identified BCL2 Associated Athanogene 3 (BAG3, a member of the BAG family of molecular chaperone proteins, as a specific VP40 PPxY interactor. Here, we demonstrate that the WW-domain of BAG3 interacts with the PPxY motif of both EBOV and MARV VP40 and, unexpectedly, inhibits budding of both eVP40 and mVP40 virus-like particles (VLPs, as well as infectious VSV-EBOV recombinants. BAG3 is a stress induced protein that regulates cellular protein homeostasis and cell survival through chaperone-mediated autophagy (CMA. Interestingly, our results show that BAG3 alters the intracellular localization of VP40 by sequestering VP40 away from the plasma membrane. As BAG3 is the first WW-domain interactor identified that negatively regulates budding of VP40 VLPs and infectious virus, we propose that the chaperone-mediated autophagy function of BAG3 represents a specific host defense strategy to counteract the function of VP40 in promoting efficient egress and spread of virus particles.

Zebrafish models of BAG3 myofibrillar myopathy suggest a toxic gain of function leading to BAG3 insufficiency.

Science.gov (United States)

Ruparelia, Avnika A; Oorschot, Viola; Vaz, Raquel; Ramm, Georg; Bryson-Richardson, Robert J

2014-12-01

Mutations in the co-chaperone Bcl2-associated athanogene 3 (BAG3) can cause myofibrillar myopathy (MFM), a childhood-onset progressive muscle disease, characterized by the formation of protein aggregates and myofibrillar disintegration. In contrast to other MFM-causing proteins, BAG3 has no direct structural role, but regulates autophagy and the degradation of misfolded proteins. To investigate the mechanism of disease in BAG3-related MFM, we expressed wild-type BAG3 or the dominant MFM-causing BAG3 (BAG3(P209L)) in zebrafish. Expression of the mutant protein results in the formation of aggregates that contain wild-type BAG3. Through the stimulation and inhibition of autophagy, we tested the prevailing hypothesis that impaired autophagic function is responsible for the formation of protein aggregates. Contrary to the existing theory, our studies reveal that inhibition of autophagy is not sufficient to induce protein aggregation. Expression of the mutant protein, however, did not induce myofibrillar disintegration and we therefore examined the effect of knocking down Bag3 function. Loss of Bag3 resulted in myofibrillar disintegration, but not in the formation of protein aggregates. Remarkably, BAG3(P209L) is able to rescue the myofibrillar disintegration phenotype, further demonstrating that its function is not impaired. Together, our knockdown and overexpression experiments identify a mechanism whereby BAG3(P209L) aggregates form, gradually reducing the pool of available BAG3, which eventually results in BAG3 insufficiency and myofibrillar disintegration. This mechanism is consistent with the childhood onset and progressive nature of MFM and suggests that reducing aggregation through enhanced degradation or inhibition of nucleation would be an effective therapy for this disease.

The Virtual Shopping Experience: using virtual presence to motivate online shopping

Directory of Open Access Journals (Sweden)

Carolyn Chin

2005-11-01

Full Text Available Online shopping has thus far tended to be a niche business – highly successful in selling digital products such as shares, software and, increasingly, music and films, it has been less successful in persuading the purchasers of ‘traditional’ goods such as cars, clothes, toiletries, or household appliances to forsake their physical retailers and move into cyberspace. In this wide-ranging review paper we investigate the issue of the virtual experience – endeavouring to understand what is needed for a successful ‘shopping experience’ online and what the possible obstacles or pitfalls along the way might be. We initially introduce the concepts of virtual presence (the sense of ‘being there’ and virtual reality, discussing the possible roles both can play in providing a solution to the problem of effective online shopping. We then consider the Experience Economy, a concept which encapsulates many of the issues related to the problem of online shopping and which suggests ways in which online retailers can enhance the effectiveness of their sites by means of a virtual ‘experience’. Having set the scene for online shopping, we discuss eTailing today in terms of direct product experience and the opportunities which cyber-shopping offers to replicate this process. Finally, we identify some of the possibilities and problems of online shopping today, illustrating the current status of virtual presence in retailing with two micro-cases of success and failure.

21 CFR 880.6050 - Ice bag.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Ice bag. 880.6050 Section 880.6050 Food and Drugs....6050 Ice bag. (a) Identification. An ice bag is a device intended for medical purposes that is in the... the body. The device may include a holder that keeps the bag in place against an external area of the...

Online Shopping Behavior

OpenAIRE

Shahzad, Hashim

2015-01-01

Online shopping is a very much developed phenomena in Scandinavian countries. Different online factors impact online consumers’ behavior differently depending on the environment of different regions. Sweden is one of the developed and technologically advanced countries. To see the impact of different factors on consumers’ online shopping behavior, the purpose of this study is to analyse the factors that influence consumers’ online shopping behavior in Sweden’s context. One of the objectives o...

Practical job shop scheduling

NARCIS (Netherlands)

Schutten, Johannes M.J.

1998-01-01

The Shifting Bottleneck procedure is an intuitive and reasonably good approximation algorithm for the notoriously difficult classical job shop scheduling problem. The principle of decomposing a classical job shop problem into a series of single-machine problems can also easily be applied to job shop

Quark bag coupling to finite size pions

International Nuclear Information System (INIS)

De Kam, J.; Pirner, H.J.

1982-01-01

A standard approximation in theories of quark bags coupled to a pion field is to treat the pion as an elementary field ignoring its substructure and finite size. A difficulty associated with these treatments in the lack of stability of the quark bag due to the rapid increase of the pion pressure on the bad as the bag size diminishes. We investigate the effects of the finite size of the qanti q pion on the pion quark bag coupling by means of a simple nonlocal pion quark interaction. With this amendment the pion pressure on the bag vanishes if the bag size goes to zero. No stability problems are encountered in this description. Furthermore, for extended pions, no longer a maximum is set to the bag parameter B. Therefore 'little bag' solutions may be found provided that B is large enough. We also discuss the possibility of a second minimum in the bag energy function. (orig.)

Bosonization relations as bag boundary conditions

International Nuclear Information System (INIS)

Nadkarni, S.; Nielsen, H.B.; Zahed, I.

1984-10-01

The more sophisticated bag models of hadrons become, the less precisely they seem to determine the bag radius. Idealizing this situation leads to the concept of exact bag models - ''Cheshire Cat'' models, CCM'S - where the physics is completely insensitive to changes in the bag radius. CCM's are constructed explitly in 1+1-dimensions, where exact bosonization relations are known. In the formalism of bag models, these relations appear as boundary conditions which ensure that the shifting of the bag wall has no physical effect. Other notable features of 1+1-dimensional CCM's are: (i) Fermion number, though classically confined, can escape the bag via a vector current anomaly at the surface. (ii) Essentially the same boundary action works for a variety of models and its symmetries determine those of the external boson fields. Remarkably enough, this 1+1-dimensional boundary action has precisely the same form as the one used in 3+1-dimensional chiral bag models, lending support to the belief that the latter are indeed approximateCCM's. These 1+1-dimensional results are expected to provide useful guidelines in the attempt to, at least approximately, besonize 3+1-dimensional QCD. (orig.)

A deformable bag model of hadrons, 1

International Nuclear Information System (INIS)

Ui, Haruo; Saito, Koich

1983-01-01

As a generalization of the MIT spherical bag model, we construct the spheroidal bag model of hadron with an arbitrary eccentricity. This generalization is made by slightly modifying the MIT linear boundary condition: The linear boundary condition is examined in detail. Our model always satisfies two necessary requirements of the MIT bag model - i.e., n.j = 0, no quark colour flux leaves the bag, and q-barq = 0, the scalar density of quark should vanish on the bag surface- and it reduces to the MIT spherical bag model in the limit of zero-eccentricity. Lagrangian formalism of our model is briefly described. The eigenfrequencies of a single massless quark confined in this spheroidal bag are numerically calculated. We obtain the level-splitting of the excited quark orbits, which is just analogous to the well-known Nilsson's splitting of single particle orbits in deformed nuclei. By using the numerical results of the lowest orbit, the effect of the bag-deformation on the mass of low-lying hadrons is estimated. It is found that, although the spherical bag is stable, the quark bag is extremely soft against the quadrupole deformation. Brief discussions are added on the mechanisms which make the spherical bag more stable. (author)

Chiral pion dynamics for spherical nucleon bags

International Nuclear Information System (INIS)

Vento, V.; Rho, M.; Nyman, E.M.; Jun, J.H.; Brown, G.E.; CEA Centre d'Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette

1980-01-01

A chirally symmetric quark-bag model for the nucleon is obtained by introducing an explicit, classical, pion field exterior to the bag. The coupling at the bag surface is determined by the requirement of a conserved axial-vector current. The pion field satisfies equations of motion corresponding to the non-linear sigma-model. We study on this paper the simplified case where the bag and the pion field are spherically symmetric. Corrections due to gluon exchange between the quarks are ignored along with other interactions which split the N- and Δ-masses. The equations of motion for the pion field are solved and we find a substantial pion pressure at the bag surface, along with an attractive contribution to the nucleon self-energy. The total energy of the system, bag plus meson cloud, turns out to be approximately Msub(n)c 2 for a wide range of bag radii, from 1.5 fm down to about 0.5 fm. Introduction of a form factor for the pion would extend the range of possible radii to even smaller values. We propose that the bag with the smallest allowed radius be identified with the 'little bag' discussed before. One surprising result of the paper is that as long as one restricts to spherically symmetric bags, restoring chiral symmetry to the bag model makes the axial-vector current coupling constant gsub(A) to be always too large compared with the experimental value for any bag radius, suggesting a deviation from spherical symmetry for the intrinsic bag wave functions of the 'ground-state' hadrons. (orig.)

Pions and the chiral bag

International Nuclear Information System (INIS)

Rho, M.

1982-01-01

As an aid to discussing the structure of nucleons and nuclei conceptual framework, heuristic arguments are presented which indicate that a hadron can be considered as a bag consisting of two different phases. The chiral structure of the phase outside the bag is discussed in terms of effective field theories and it is shown to what extent experiments in nuclei can constrain the structure of such theories. Results thus obtained are then combined to set up a set of equations for the bag structure of u and d hadrons, incorporating asymptotic freedom in the phase inside of the bag confinement of quarks and gluons by boundary conditions and spontaneously broken chiral symmetry in the outside. This set of equations which represent a chirally invariant generalization of the M.I.T. bag model is then solved. (U.K.)

Bag models of hadrons

International Nuclear Information System (INIS)

DeTar, C.E.; Donoghue, J.F.

1983-01-01

We believe further progress in the bag model must come from a better understanding of QCD. The bag theory is basically a simple model of the vacuum. A ''perturbative'' vacuum of finite extent is found inside the bag, while the ''true'' vacuum is found outside. The formation of the bag can be viewed as a phase change between the two types of vacuum. In what sense does QCD support this view. There have been many recent attempts to characterize the QCD vacuum. Of particular relevance to the bag model is recent work by Hansson et al. They set out to determine the structure of the vacuum wave function by using a variational argument. Their ''trial'' wave function was inspired by the bag model, but their intention was to describe general features of QCD. Their work starts from the realization that with the usual perturbative model of the vacuum a J /sup PC/ = 0 ++ glueball state can be made with m 2 ++ glueball (C. B. Thorn, unpublished), which leads to a state with m 2 < 0 when c.m. corrections are included (65). Hansson et al show that the perturbative vacuum can lower its energy by filling up with scalar glueballs. They calculate the energy of glueballs containing two and four gluons and find that the energy of the four-gluon state is higher. Therefore the vacuum energy reaches a minimum when the glueballs start to overlap

Customer experience with online shopping : what are the unique experiences customers seek from online shopping?

OpenAIRE

Jin, Daoyan

2013-01-01

Over the last decade, there has been a great change in consumers' shopping behavior along with technological change. Online shopping is the use of computer technology for better shopping performance. Retailers are busy in studying consumers' behavior to see their attitudes toward online shopping and to meet the demand of online shoppers. Due to my interest in online business, I have also decided to study about customers' attitudes toward online shopping and specifically regarding factors that...

GENDER AND SHOPPING BEHAVIOR OUTCOMES IN THE CONTEXT OF SHOPPING CENTERS

Directory of Open Access Journals (Sweden)

Ioana Nicoleta ABRUDAN

2016-09-01

Full Text Available Understanding consumer behavior can be divided into three parts: before visiting the stores or shopping centers, during the visit, and after. From the point of view of the final result intended by retailers, satisfying customers in terms of profitability, all three components are equally important. A relevant segmentation criterion for most products and stores is gender. Previous research suggests that gender influences shopping motivations, the way people shop and shopping behavior outcomes. The purpose of this article is to investigate if there are, indeed, differences between shopping behavior outputs of women and men (affective loyalty (satisfaction and conative loyalty, as found by certain researchers, and also in terms of the factors that influence the formation of conative loyalty. The results confirm that there are few significant differences in the satisfaction level, although for women all values are slightly higher, and none in the repurchase and recommendation intentions between the two genders. Conative loyalty formation (defined as intent to repurchase and recommend takes place differently between the two genders.

Effects of bagging materials and CaCl2 spray on fruit calcium concentration in fruit-bagged apple trees

International Nuclear Information System (INIS)

Yim, Y.J.; Choi, J.S.; Kim, S.B.

1989-01-01

This experiment was carried out to investigate the effects of bagging materials and CaCl 2 spray on fruit Ca concentration in fruit-bagged apple trees (Malus domestica Borkh.). No difference was noted in fruit Ca concentration among bagging materials during the growing season. And also, there was no difference in fruit Ca concentration between bagged and non-bagged fruits. The fruit flesh Ca concentration of bagged fruits was significantly lower than that of non-bagged fruits in the same tree, which 0.5 % CaCl 2 was sprayed 5 times in the late growing season. The radioactivity of 45 Ca was highest in the sprayed shoot leaves and bark, while only a trace amount was detected in the fruit and shoot proximate to the treated shoot 3 weeks after 3 times application of 45 CaCl 2 (5 micro Ci/ml). As a result, it is confirmed that the Ca once accumulated in a specific part is hardly retranslocated. Therefore, it is concluded that Ca foliar spray to the fruit-bagged tree has no influence on Ca concentration in the fruit

Quantum chromodynamics, chiral symmetry and bag models

International Nuclear Information System (INIS)

Soyeur, M.

1983-08-01

This course deals with the following subjects: quarks; quantum chromodynamics (the classical Lagrangian of QCD, quark masses, the classical equations of motion of QCD, general properties, lattices); chiral symmetry (massless free Dirac theory, realizations, the σ-model); the M.I.T. bag model (basic assumptions and equations of motion, spherical cavity approximation, properties of hadrons); the chiral bag models (basic assumptions, the cloudy bag model, the little bag model); non-topological soliton bag models

Quark structure of nucleons: the third bag

International Nuclear Information System (INIS)

Wilets, L.

1983-01-01

The soliton bag model proposed by Friedberg and Lee is discussed. Unlike the other bag models, it treats the confining bag as a fully dynamical object. A scalar soliton field is introduced to effect confinement. The combined quark-soliton system (plus gluons, Higgs fields, counter terms) is described by a Hamiltonian or Lagrangian. The standard bag models do not have a complete Hamiltonian or Lagrangian. The resulting bag can undergo oscillations, rotations and dynamical distortions

Determination of H2 Diffusion Rates through Various Closures on TRU Waste Bag-Out Bags

International Nuclear Information System (INIS)

Noll, Phillip D. Jr.; Callis, E. Larry; Norman, Kirsten M.

1999-01-01

The amount of H 2 diffusion through twist and tape (horse-tail), wire tie, plastic tie, and heat sealed closures on transuranic (TRU) waste bag-out bags has been determined. H 2 diffusion through wire and plastic tie closures on TRU waste bag-out bags has not been previously characterized and, as such, TRU waste drums containing bags with these closures cannot be certified and/or shipped to the Waste Isolation Pilot Plant (WIPP). Since wire ties have been used at Los Alamos National Laboratory (LANL) from 1980 to 1991 and the plastic ties from 1991 to the present, there are currently thousands of waste drums that cannot be shipped to the WIPP site. Repackaging the waste would be prohibitively expensive. Diffusion experiments performed on the above mentioned closures show that the diffusion rates of plastic tie and horse-tail closures are greater than the accepted value presented in the TRU-PACT 11 Safety Analysis Report (SAR). Diffusion rates for wire tie closures are not statistically different from the SAR value. Thus, drums containing bags with these closures can now potentially be certified which would allow for their consequent shipment to WIPP

Gravitating lepton bag model

International Nuclear Information System (INIS)

Burinskii, A.

2015-01-01

The Kerr–Newman (KN) black hole (BH) solution exhibits the external gravitational and electromagnetic field corresponding to that of the Dirac electron. For the large spin/mass ratio, a ≫ m, the BH loses horizons and acquires a naked singular ring creating two-sheeted topology. This space is regularized by the Higgs mechanism of symmetry breaking, leading to an extended particle that has a regular spinning core compatible with the external KN solution. We show that this core has much in common with the known MIT and SLAC bag models, but has the important advantage of being in accordance with the external gravitational and electromagnetic fields of the KN solution. A peculiar two-sheeted structure of Kerr’s gravity provides a framework for the implementation of the Higgs mechanism of symmetry breaking in configuration space in accordance with the concept of the electroweak sector of the Standard Model. Similar to other bag models, the KN bag is flexible and pliant to deformations. For parameters of a spinning electron, the bag takes the shape of a thin rotating disk of the Compton radius, with a ring–string structure and a quark-like singular pole formed at the sharp edge of this disk, indicating that the considered lepton bag forms a single bag–string–quark system

Online shopping hesitation.

Science.gov (United States)

Cho, Chang-Hoan; Kang, Jaewon; Cheon, Hongsik John

2006-06-01

This study was designed to understand which factors influence consumer hesitation or delay in online product purchases. The study examined four groups of variables (i.e., consumer characteristics, contextual factors perceived uncertainty factors, and medium/channel innovation factors) that predict three types of online shopping hesitation (i.e., overall hesitation, shopping cart abandonment, and hesitation at the final payment stage). We found that different sets of delay factors are related to different aspects of online shopping hesitation. The study concludes with suggestion for various delay-reduction devices to help consumers close their online decision hesitation.

Bag pigtråd

DEFF Research Database (Denmark)

Bjerre, Jacob Halvas

2015-01-01

BogFeature om Inger Bjørn Knudsen: Bag Pigtråd - Rom flygtningelejr 1945-1948. Udg. af Lemvig Museum, 2014. 80 sider......BogFeature om Inger Bjørn Knudsen: Bag Pigtråd - Rom flygtningelejr 1945-1948. Udg. af Lemvig Museum, 2014. 80 sider...

The influences of social e-shopping in enhancing young women’s online shopping behaviour

OpenAIRE

Dennis, C; Morgan, A; Wright, LT; Jayawardhena, C

2010-01-01

Copyright @ 2010 Westburn Publishers Ltd The background to this paper is that shoppers, particularly women, are motivated by a variety of different reasons, including socialising and enjoyment. Despite the growth of Internet retailing (e-retailing), these social needs are largely unmet in e-shopping. In the high street, women do most of the shopping but online shopping (e-shopping) tends to be dominated by male shoppers. At the same time, social networking is growing fast and is especially...

19 CFR 148.83 - Diplomatic and consular bags.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 2 2010-04-01 2010-04-01 false Diplomatic and consular bags. 148.83 Section 148... bags. (a) Diplomatic bags. The contents of diplomatic bags are restricted to diplomatic documents and articles intended exclusively for official use and packages constituting the diplomatic bag must bear...

Supporting shop floor intelligence

DEFF Research Database (Denmark)

Carstensen, Peter; Schmidt, Kjeld; Wiil, Uffe Kock

1999-01-01

Many manufacturing enterprises are now trying to introduce various forms of flexible work organizations on the shop floor. However, existing computer-based production planning and control systems pose severe obstacles for autonomous working groups and other kinds of shop floor control to become r......-to-day production planning by supporting intelligent and responsible workers in their situated coordination activities on the shop floor....

49 CFR 173.166 - Air bag inflators, air bag modules and seat-belt pretensioners.

Science.gov (United States)

2010-10-01

... generant and, in some cases, a pressure vessel (cylinder)) is a gas generator used to inflate an air bag in... domestic transportation by highway, rail freight, cargo vessel or cargo aircraft, a serviceable air bag...

Role of blood bag temperature indicators in maintaining patent temperature of the returned unused blood bags in blood bank.

Science.gov (United States)

Nurasyikin, Y; Leong, C F; Fadhlullah, T M; Hafiz, W M; Nadiah, Z; Atieqah, A N; Ling, T J; Das, S

2011-01-01

The main objective of the present study was to evaluate the temperature chain of red blood cells (RBC) returned unused blood bags using blood temperature indicator and ascertain the factors like transportation time, type, size of coolant box and number of bags per box. A total of 250 blood bags with the indicator were observed for the temperature changes with other factors like transportation time, type and size of coolant box and number of bags per box. The recordings were performed at several checkpoints located between the blood bank and the wards. Out of the 250 bags, 74 (29.6%) showed colour changes in which 64 (86.3%) were returned unused (RU) blood bags. The transportation time for these 74 bags was 818.3 ± 941.643 min, significantly higher than bags without colour changes, (p=0.02). Interestingly, 71.4% of the colour changes occurred within the ward. The 7 litre coolant box with an average of 1-5 blood bags per box had a statistically significant higher percentage of colour change with 59.2% compared to the 5 litre coolant box (p=0.05). This study showed that the temperature chain of blood bags was often not well maintained. These results could be mainly due to the non-adherence to the standard operating procedure (SOP) of blood transfusion and the usage of non-standardized coolant boxes.

Shopping Problems among High School Students

Science.gov (United States)

Grant, Jon E.; Potenza, Marc N.; Krishnan-Sarin, Suchitra; Cavallo, Dana A.; Desai, Rani A.

2010-01-01

Background Although shopping behavior among adolescents is normal, for some the shopping becomes problematic. An assessment of adolescent shopping behavior along a continuum of severity and its relationship to other behaviors and health issues is incompletely understood. Methods A large sample of high school students (n=3999) was examined using a self-report survey with 153 questions concerning demographic characteristics, shopping behaviors, other health behaviors including substance use, and functioning variables such as grades and violent behavior. Results The overall prevalence of problem shopping was 3.5% (95%CI: 2.93–4.07). Regular smoking, marijuana and other drug use, sadness and hopelessness, and antisocial behaviors (e.g., fighting, carrying weapons) were associated with problem shopping behavior in both boys and girls. Heavy alcohol use was significantly associated with problem shopping only in girls. Conclusion Problem shopping appears fairly common among high school students and is associated with symptoms of depression and a range of potentially addictive and antisocial behaviors. Significant distress and diminished behavioral control suggest that excessive shopping may often have significant associated morbidity. Additional research is needed to develop specific prevention and treatment strategies for adolescents who report problems with shopping. PMID:21497217

Shopping problems among high school students.

Science.gov (United States)

Grant, Jon E; Potenza, Marc N; Krishnan-Sarin, Suchitra; Cavallo, Dana A; Desai, Rani A

2011-01-01

Although shopping behavior among adolescents is normal, for some, the shopping becomes problematic. An assessment of adolescent shopping behavior along a continuum of severity and its relationship to other behaviors and health issues is incompletely understood. A large sample of high school students (n = 3999) was examined using a self-report survey with 153 questions concerning demographic characteristics, shopping behaviors, other health behaviors including substance use, and functioning variables such as grades and violent behavior. The overall prevalence of problem shopping was 3.5% (95% CI, 2.93-4.07). Regular smoking, marijuana and other drug use, sadness and hopelessness, and antisocial behaviors (e.g., fighting, carrying weapons) were associated with problem shopping behavior in both boys and girls. Heavy alcohol use was significantly associated with problem shopping only in girls. Problem shopping appears fairly common among high school students and is associated with symptoms of depression and a range of potentially addictive and antisocial behaviors. Significant distress and diminished behavioral control suggest that excessive shopping may often have significant associated morbidity. Additional research is needed to develop specific prevention and treatment strategies for adolescents who report problems with shopping. Copyright © 2011 Elsevier Inc. All rights reserved.

Binjai Shopping Mall : Arsitektur Metafora

OpenAIRE

Abadsyah, Haris

2014-01-01

City of Binjai have a potential to increase economic growth, especially in the field of trade and services.It can be seen from appearance of the commercial building like the shopping center ( Binjai Super Mall, Ramayana and Suzuya ) Construction of Binjai Shopping Mall intended for planning new shopping centers that provide public kebuthan in Binjai and well planned shopping center with optimal processing space and create a comfortable and pleasant atmosphere. In addition, the ...

Consumers’ Attitude towards Online Shopping : Factors influencing Gotland consumers to shop online

OpenAIRE

Sultan, Muhammad Umar; Uddin, Md. Nasir

2011-01-01

In the era of globalization electronic marketing is a great revolution.  Over the last decade maximum business organizations are running with technological change.  Online shopping or marketing is the use of technology (i.e., computer) for better marketing performance. And retailers are devising strategies to meet the demand of online shoppers; they are busy in studying consumer behavior in the field of online shopping, to see the consumer attitudes towards online shopping. Therefore we have ...

The Multifunctional Protein BAG3

Directory of Open Access Journals (Sweden)

Valerie D. Myers, MS

2018-02-01

Full Text Available The B-cell lymphoma 2–associated anthanogene (BAG3 protein is expressed most prominently in the heart, the skeletal muscle, and in many forms of cancer. In the heart, it serves as a co-chaperone with heat shock proteins in facilitating autophagy; binds to B-cell lymphoma 2, resulting in inhibition of apoptosis; attaches actin to the Z disk, providing structural support for the sarcomere; and links the α-adrenergic receptor with the L-type Ca2+ channel. When BAG3 is overexpressed in cancer cells, it facilitates prosurvival pathways that lead to insensitivity to chemotherapy, metastasis, cell migration, and invasiveness. In contrast, in the heart, mutations in BAG3 have been associated with a variety of phenotypes, including both hypertrophic/restrictive and dilated cardiomyopathy. In murine skeletal muscle and vasculature, a mutation in BAG3 leads to critical limb ischemia after femoral artery ligation. An understanding of the biology of BAG3 is relevant because it may provide a therapeutic target in patients with both cardiac and skeletal muscle disease.

ARE PLASTIC GROCERY BAGS SACKING THE ENVIRONMENT?

OpenAIRE

Mangal Gogte

2009-01-01

This paper is oriented on analysis impacts of plastic bags on environment. In this paper is analyzed did plastic bags are so harmful, and what are the main ingredients of it. One part of this paper is oriented on effects of plastic bags and management of their usage. There is also made comparative analysis between impacts of plastic and paper bags on environment.

A rotating bag model for hadrons. 2

International Nuclear Information System (INIS)

Iwasaki, Masaharu

1994-01-01

The MIT bag model is modified in order to describe rotational motion of hadrons. It has a kind of 'diatomic molecular' structure; The rotational excitation of the MIT bag is described by the polarized two colored sub-bags which are connected with each other by the gluon flux. One sub-bag contains a quark and the other has an antiquark for mesons. For baryons, the latter sub-bag contains the remaining two quarks instead of the antiquark. The Regge trajectories of hadrons are explained qualitatively by our new model with the usual MIT bag parameters. In particular the Regge slopes are reproduced fairly well. It is also pointed out that the gluon flux plays an important role in the rotational motion of hadrons. (author)

Acoustic Multipurpose Cargo Transfer Bag

Science.gov (United States)

Baccus, Shelley

2015-01-01

The Logistics Reduction (LR) project within the Advanced Exploration Systems (AES) program is tasked with reducing logistical mass and repurposing logistical items. Multipurpose Cargo Transfer Bags (MCTB) are designed to be the same external volume as a regular cargo transfer bag, the common logistics carrier for the International Space Station. After use as a cargo bag, the MCTB can be unzipped and unfolded to be reused. This Acoustic MCTBs transform into acoustic blankets after the initial logistics carrying objective is complete.

Bagworm bags as portable armour against invertebrate predators

Directory of Open Access Journals (Sweden)

Shinji Sugiura

2016-02-01

Full Text Available Some animals have evolved the use of environmental materials as “portable armour” against natural enemies. Portable bags that bagworm larvae (Lepidoptera: Psychidae construct using their own silk and plant parts are generally believed to play an important role as a physical barrier against natural enemies. However, no experimental studies have tested the importance of bags as portable armour against predators. To clarify the defensive function, I studied the bagworm Eumeta minuscula and a potential predator Calosoma maximoviczi (Coleoptera: Carabidae. Under laboratory conditions, all bagworm larvae were attacked by carabid adults, but successfully defended themselves against the predators’ mandibles using their own bags. The portable bags, which are composed mainly of host plant twigs, may function as a physical barrier against predator mandibles. To test this hypothesis, I removed the twig bags and replaced some with herb leaf bags; all bag-removed larvae were easily caught and predated by carabids, while all bag-replaced larvae could successfully defend themselves against carabid attacks. Therefore, various types of portable bags can protect bagworm larvae from carabid attacks. This is the first study to test the defensive function of bagworm portable bags against invertebrate predators.

Bagworm bags as portable armour against invertebrate predators.

Science.gov (United States)

Sugiura, Shinji

2016-01-01

Some animals have evolved the use of environmental materials as "portable armour" against natural enemies. Portable bags that bagworm larvae (Lepidoptera: Psychidae) construct using their own silk and plant parts are generally believed to play an important role as a physical barrier against natural enemies. However, no experimental studies have tested the importance of bags as portable armour against predators. To clarify the defensive function, I studied the bagworm Eumeta minuscula and a potential predator Calosoma maximoviczi (Coleoptera: Carabidae). Under laboratory conditions, all bagworm larvae were attacked by carabid adults, but successfully defended themselves against the predators' mandibles using their own bags. The portable bags, which are composed mainly of host plant twigs, may function as a physical barrier against predator mandibles. To test this hypothesis, I removed the twig bags and replaced some with herb leaf bags; all bag-removed larvae were easily caught and predated by carabids, while all bag-replaced larvae could successfully defend themselves against carabid attacks. Therefore, various types of portable bags can protect bagworm larvae from carabid attacks. This is the first study to test the defensive function of bagworm portable bags against invertebrate predators.

ARE PLASTIC GROCERY BAGS SACKING THE ENVIRONMENT?

Directory of Open Access Journals (Sweden)

Mangal Gogte

2009-12-01

Full Text Available This paper is oriented on analysis impacts of plastic bags on environment. In this paper is analyzed did plastic bags are so harmful, and what are the main ingredients of it. One part of this paper is oriented on effects of plastic bags and management of their usage. There is also made comparative analysis between impacts of plastic and paper bags on environment.

Shopping in discount stores

DEFF Research Database (Denmark)

Zielke, Stephan

2014-01-01

quarters of intentions to shop in discount stores. Value perception has the strongest total effect, which is partly mediated by enjoyment, shame and guilt. Attributions influence the shopping intention indirectly via value perception and emotions. The inferior quality attribution has the strongest total......This paper analyzes the impact of price-related attributions, emotions and value perception on the intention to shop at grocery discounters in an integrated framework. Moderating effects of price consciousness are also analyzed. The results show that the proposed model explains almost three...... effect, followed by the efficiency of the business model attribution. The unfairness to stakeholders and the tricks in price communication attribution mostly influence the shopping intention for less price-conscious customers....

Effects of quantum entropy on bag constant

International Nuclear Information System (INIS)

Miller, D.E.; Tawfik, A.

2012-01-01

The effects of quantum entropy on the bag constant are studied at low temperatures and for small chemical potentials. The inclusion of the quantum entropy of the quarks in the equation of state provides the hadronic bag with an additional heat which causes a decrease in the effective latent heat inside the bag. We have considered two types of baryonic bags, Δ and Ω - . In both cases we have found that the bag constant without the quantum entropy almost does not change with temperature and quark chemical potential. The contribution from the quantum entropy to the equation of state clearly decreases the value of the bag constant. Furthermore, we construct states densities for quarks using the 'Thomas Fermi model' and take into consideration a thermal potential for the interaction. (author)

Vape Shop Employees: Public Health Advocates?

OpenAIRE

Hart, Joy L; Walker, Kandi L; Sears, Clara G; Lee, Alexander S; Smith, Courteney; Siu, Allison; Keith, Rachel; Ridner, S. Lee

2017-01-01

INTRODUCTION E-cigarettes have increased in popularity and given rise to a new type of sales outlet?the vape shop. Expanding on work examining vape shop employee e-cigarette and tobacco attitudes and behaviors 1 , this study examined key messages that vape shop employees communicate to customers. METHODS Using informal interviews, observations, and a cross-sectional survey, we examined vape shop employees? (n=16) perceptions and e-cigarette use. Data were collected in nine vape shops in Louis...

Consumer Intention toward Bringing Your Own Shopping Bags in Taiwan: An Application of Ethics Perspective and Theory of Planned Behavior

Directory of Open Access Journals (Sweden)

Sheng-Hsiung Chang

2018-05-01

Full Text Available Following Chan and coworkers’ (2008 research, the current study integrated Hunt and Vitell’s (1986 ethics perspective and Theory of Planned Behavior (TPB to present a model that explains consumers’ intention to “Bring Your Own Shopping Bags” (BYOB with grocery shopping. The proposed model is empirically validated in Taiwan. Based on a survey of 601 respondents, the findings suggest that consumers’ deontological evaluation is positively related to their attitude, subjective norm, and perceived behavioral control, while teleological evaluation is positively related to perceived behavioral control only. In addition, the results also indicate that consumers’ attitude and perceived behavioral control has a positive relationship with BYOB intention, while subjective norm does not have a signification relationship with BYOB intention. In sum, this study contributes to the literature by providing insights for applying general ethics and theory of planned behavior to explain consumers’ BYOB behavior. The results also provide policy makers guidelines regarding BYOB. Managerial implications and research limitations are discussed at the end of this paper.

Vapor pressure measured with inflatable plastic bag

Science.gov (United States)

1965-01-01

Deflated plastic bag in a vacuum chamber measures initial low vapor pressures of materials. The bag captures the test sample vapors and visual observation of the vapor-inflated bag under increasing external pressures yields pertinent data.

Analysis of HDAC6 and BAG3-Aggresome Pathways in African Swine Fever Viral Factory Formation

Directory of Open Access Journals (Sweden)

Raquel Muñoz-Moreno

2015-04-01

Full Text Available African swine fever virus (ASFV is a double-stranded DNA virus causing a hemorrhagic fever disease with high mortality rates and severe economic losses in pigs worldwide. ASFV replicates in perinuclear sites called viral factories (VFs that are morphologically similar to cellular aggresomes. This fact raises the possibility that both VFs and aggresomes may be the same structure. However, little is known about the process involved in the formation of these viral replication platforms. In order to expand our knowledge on the assembly of ASFV replication sites, we have analyzed the involvement of both canonical aggresome pathways in the formation of ASFV VFs: HDAC6 and BAG3. HDAC6 interacts with a component of the dynein motor complex (dynactin/p150Glued and ubiquitinated proteins, transporting them to the microtubule-organizing center (MTOC and leading to aggresome formation, while BAG3 is mediating the recruitment of non-ubiquitinated proteins through a similar mechanism. Tubacin-mediated HDAC6 inhibition and silencing of BAG3 pathways, individually or simultaneously, did not prevent ASFV VF formation. These findings show that HDAC6 and Bag3 are not required for VFs formation suggesting that aggresomes and VFs are not the same structures. However, alternative unexplored pathways may be involved in the formation of aggresomes.

The Effects of Shopping Orientations, Consumer Innovativeness, Purchase Experience, and Gender on Intention to Shop for Fashion Products Online

Directory of Open Access Journals (Sweden)

Ratih Puspa Nirmala

2011-02-01

Full Text Available Nowadays, many fashion retailers or marketers use the power of internet to promote and sell their products. This research examines the effects of consumers’ shopping orientations (brand/fashion consciousness, shopping enjoyment, price consciousness, convenience/time consciousness, shopping confidence, in-home shopping tendency, consumer innovativeness, online purchase experience for fashion products, and gender on consumers’ intention to shop for fashion products online. Data were collected through online surveys from the population of internet users in Indonesia, aged between 15 and 30 years old (generation Y, who had bought or browsed fashion products through the internet (N=210. This research is a quantitative research which uses purposive sampling and multiple regression analysis. Results show that the effects of several shopping orientations (shopping enjoyment, price consciousness, in-home shopping tendency, consumer innovativeness, online purchase experience for fashion products, and gender, are significant on consumers’ intention to shop for fashion products online. Furthermore, gender is marginally significant related to consumers’ intention to shop for fashion products online. Surprisingly, women tend to have lower intentions to shop for fashion products online compared to men.

A generic taxonomy of shopping motives among hypermarkets (hyper-stores customers and the relationship with demographic variables

Directory of Open Access Journals (Sweden)

M. Dhurup

2008-12-01

Full Text Available Purpose of the study: Noting that the motive for shopping is located within the paradigm of buying behaviour of consumers; the study seeks to complement existing literature by examining whether a configuration of shopper motives could be developed, thereby revealing taxonomy of hypermarket (hyper-store shoppers. In addition the study seeks to establish whether shopping motives is shaped by demographic variables. Problem statement: Although the motive for shopping and its antecedents has been approached from various perspectives, it has been accentuated in literature that traditional utilitarian aspects of product acquisition explanations may not fully reflect the totality of a shopping experience. With such affirmations, shopping may be harmonised with hedonic activities when considered within a hypermarket/hyper-store South African context. Methodology: The study adopted a conceptual framework for identifying relatable factors (using exploratory factor analysis that influence consumer motivation for shopping within hypermarket (hyper-store environments. Reliability and validity of the scale was established. Findings: A 13 item scale was developed. Shopping seems to be both a utilitarian and a hedonic consumption experience with three auxiliary categories of hedonic motivations, namely diversion, recreational and sensory stimulated shoppers. In examining the motives for shopping and demographic variables, diversion appears to vary with levels of education. Value of the research: Enhancing one's understanding of the "softer" issues of shopping, namely diversion, recreational and sensory stimulated shoppers is essential, as they represent possible differentiating factors in a highly competitive and often commoditised retail market. Acquaintance of distinct shopper segments is useful for retailers in assembling marketing communication strategies and designing appealing store environments. Conclusion: Whilst shopper typologies may hold several

Online Shopping: Advantages over the Offline Alternative

OpenAIRE

Dr Joshua Chang

2003-01-01

The advent of the Internet as a shopping medium has enabled shoppers to gain shopping benefits such as convenience and time-saving, better information, and price savings. This paper aims to provide a better understanding of the benefits of Internet shopping by identifying and discussing the advantages of Internet shopping over traditional storefront shopping.

Massless quark wavefunction in the deformed bag

International Nuclear Information System (INIS)

Min, D.P.; Park, B.Y.; Koh, Y.S.

1984-01-01

The quark wavefunctions inside the deformed bag are obtained using a modified linear boundary condition stemming from the MIT bag Lagrangian with an additional term. We propose an exact method to obtain the quark wavefunction even for a spheroidally deformed bag. (Author)

Biodegradable bags for the production of plant seedlings

Directory of Open Access Journals (Sweden)

Ana Paula Bilck

2014-10-01

Full Text Available The production of plant seedlings has traditionally used polyethylene bags, which are thrown out in the soil or burned after transplant because the large amount of organic material attached to the bags makes recycling difficult. Additionally, when a seedling is taken from the bag for transplant, there is the risk of root damage, which compromises the plant’s development. In this study, we developed biodegradable bags to be used in seedling production, and we verify their influence on the development of Brazilian ginseng (Pfaffia glomerata (Spreng Pedersen, when the plant is planted without being removed from the bag. Both black and white biodegradable bags remained intact throughout the seedling production period (60 days. After being transplanted into containers (240 days, they were completely biodegraded, and there was no significant difference between the dry mass of these plants and that of plants that were transplanted without the bags. The plants that were cultivated without being removed from the polyethylene bags had root development difficulties, and the wrapping showed no signs of degradation. The use of biodegradable films is an alternative for the production of bags for seedlings, as these can then be transplanted directly into the soil without removing the bag, reducing the risk of damage to the roots during the moment of transplant.

Multi-monopoles and magnetic bags

International Nuclear Information System (INIS)

Bolognesi, Stefano

2006-01-01

By analogy with the multi-vortices, we show that also multi-monopoles become magnetic bags in the large n limit. This simplification allows us to compute the spectrum and the profile functions by requiring the minimization of the energy of the bag. We consider in detail the case of the magnetic bag in the limit of vanishing potential and we find that it saturates the Bogomol'nyi bound and there is an infinite set of different shapes of allowed bags. This is consistent with the existence of a moduli space of solutions for the BPS multi-monopoles. We discuss the string theory interpretation of our result and also the relation between the 't Hooft large n limit of certain supersymmetric gauge theories and the large n limit of multi-monopoles. We then consider multi-monopoles in the cosmological context and provide a mechanism that could lead to their production

Autoregulation of Co-Chaperone BAG3 Gene Transcription

OpenAIRE

Gentilella, Antonio; Khalili, Kamel

2009-01-01

The Bcl-2-associated athanogene, BAG, protein family through their BAG domain associates with the heat shock protein 70 (HSP-70) and modulates its chaperone activity. One member of this family, BAG3, appears to play an important role in protein homeostasis, as its expression promotes cell survival by preventing polyubiquitination of Hsp-70 client proteins. Expression of BAG3 is enhanced by a variety of stress-inducing agents. Here we describe a role for BAG3 to modulate transcription of its o...

Baryon bags in strong coupling QCD

Science.gov (United States)

Gattringer, Christof

2018-04-01

We discuss lattice QCD with one flavor of staggered fermions and show that in the path integral the baryon contributions can be fully separated from quark and diquark contributions. The baryonic degrees of freedom (d.o.f.) are independent of the gauge field, and the corresponding free fermion action describes the baryons through the joint propagation of three quarks. The nonbaryonic dynamics is described by quark and diquark terms that couple to the gauge field. When evaluating the quark and diquark contributions in the strong coupling limit, the partition function completely factorizes into baryon bags and a complementary domain. Baryon bags are regions in space-time where the dynamics is described by a single free fermion made out of three quarks propagating coherently as a baryon. Outside the baryon bags, the relevant d.o.f. are monomers and dimers for quarks and diquarks. The partition sum is a sum over all baryon bag configurations, and for each bag, a free fermion determinant appears as a weight factor.

Bag model with broken chiral symmetry

International Nuclear Information System (INIS)

Efrosinin, V.P.; Zaikin, D.A.

1986-01-01

A variant of the bag model in which chiral symmetry is broken and which provides a description of all the experimental data on the light hadrons, including the pion, is discussed. The pion and kaon decay constants are calculated in this model. The problem of taking into account the center-of-mass motion in bag models and the boundary conditions in the bag model with broken chiral symmetry are also discussed

PENGARUH ATMOSFER PUSAT BELANJA PADA SHOPPING VALUE

Directory of Open Access Journals (Sweden)

Astrid Kusumowidagdo

2015-11-01

Full Text Available AbstractAt the moment, the creation of shopping environment design that provides certain sensation and experience become strategy of the shopping center. This research aims to find out about the influence of shopping center’s atmosphere towards shopping value. The formative factors of shopping centre’s atmosphere are architectural features, interior features and support facilities. The research begins with a focus group to adjust the indicators of the previous research to the present research’s object. The next stage of research is done with a multiple regression analysis. The research object is the atmosphere condition of Senayan City shopping center in Jakarta and the subjects are samples totaling to sixty people. The samples are visitors from the middle-class segment between the age of 18-35.The research finds that architectural features, interior features and support facilities collectively bring an influence towards shopping value in Senayan City Pusat belanja, wether partially, only interior features show the significant influence towards shopping value.Keywords: design, atmosphere, shopping centre, shopping value.AbstrakSaat ini penciptaan lingkungan belanja dengan yang memberikan sensasi dan pengalaman telah menjadi bagian dari strategi bisnis pusat belanja. Penelitian ini bertujuan untuk menelusuri pengaruh atmosfer pusat belanja terhadap shopping value. Atmosfer pusat belanja dibentuk oleh faktor-faktor yaitu fitur arsitektur, fitur interior dan fasilitas penunjang. Penelitian ini diawali dengan focus group untuk penentuan indikator yang tepat dan dilanjutkan dengan survey pada 60 orang dengan usia 18-35 tahun yang bersegmen menengah. Obyek penelitian adalahatmosfer dari pusat belanja Senayan City. Hasil penelitian menunjukkan terdapat hubungan dari faktor-faktor atmosfer pusat belanja secara serempak pada shopping value, sedangkan secara parsial hanya fitur interior yang memberikan pengaruh signifikan pada shopping value

The Cheshire Cat principle for hybrid bag models

International Nuclear Information System (INIS)

Nielsen, H.B.

1987-05-01

The Cheshire Cat point of view where the bag in the chiral bag model has no physical significance, but only a notational one is argued for. It is explained how a fermion - in, say, a 1+1 dimensional exact Cheshire Cat model - escapes the bag by means of an anomaly. The possibility to construct sophisticated hybrid bag models is suggested which use the lack of physical significance of the bag to fix the many parameters so as to anyway give hope of a phenomenologically sensible model. (orig.)

The quark bag model

International Nuclear Information System (INIS)

Hasenfratz, P.; Kuti, J.

1978-01-01

The quark bag model is reviewed here with particular emphasis on spectroscopic applications and the discussion of exotic objects as baryonium, gluonium, and the quark phase of matter. The physical vacuum is pictured in the model as a two-phase medium. In normal phase of the vacuum, outside hadrons, the propagation of quark and gluon fields is forbidden. When small bubbles in a second phase are created in the medium of the normal phase with a characteristic size of one fermi, the hadron constituent fields may propagate inside the bubbles in normal manner. The bubble (bag) is stabilized against the pressure of the confined hadron constituent fields by vacuum pressure and surface tension. Inside the bag the colored quarks and gluons are governed by the equations of quantum chromodynamics. (Auth.)

Extended Stability of Epinephrine Hydrochloride Injection in Polyvinyl Chloride Bags Stored in Amber Ultraviolet Light-Blocking Bags.

Science.gov (United States)

Van Matre, Edward T; Ho, Kang C; Lyda, Clark; Fullmer, Beth A; Oldland, Alan R; Kiser, Tyree H

2017-09-01

Objective: The objective of this study was to evaluate the stability of epinephrine hydrochloride in 0.9% sodium chloride in polyvinyl chloride bags for up to 60 days. Methods: Dilutions of epinephrine hydrochloride to concentrations of 16 and 64 µg/mL were performed under aseptic conditions. The bags were then placed into ultraviolet light-blocking bags and stored at room temperature (23°C-25°C) or under refrigeration (3°C-5°C). Three samples of each preparation and storage environment were analyzed on days 0, 30, 45, and 60. Physical stability was performed by visual examination. The pH was assessed at baseline and upon final degradation evaluation. Sterility of the samples was not assessed. Chemical stability of epinephrine hydrochloride was evaluated using high-performance liquid chromatography. To determine the stability-indicating nature of the assay, degradation 12 months following preparation was evaluated. Samples were considered stable if there was less than 10% degradation of the initial concentration. Results: Epinephrine hydrochloride diluted to 16 and 64 µg/mL with 0.9% sodium chloride injection and stored in amber ultraviolet light-blocking bags was physically stable throughout the study. No precipitation was observed. At days 30 and 45, all bags had less than 10% degradation. At day 60, all refrigerated bags had less than 10% degradation. Overall, the mean concentration of all measurements demonstrated less than 10% degradation at 60 days at room temperature and under refrigeration. Conclusion: Epinephrine hydrochloride diluted to 16 and 64 µg/mL with 0.9% sodium chloride injection in polyvinyl chloride bags stored in amber ultraviolet light-blocking bags was stable up to 45 days at room temperature and up to 60 days under refrigeration.

Recent status of the chiral bag model

International Nuclear Information System (INIS)

Hosaka, Atsushi; Toki, Hiroshi.

1995-01-01

In this note, recent status of the chiral bag model is presented. As it combines the MIT quark bag model and the Skyrme model, the chiral bag model interpolates the two models smoothly as a function of the chiral bag radius R. The correct limit of R → ∞ is reproduced by including the higher order terms in the Ω expansion of the cranking method. It resolves the so-called small g A problem in a class of models where the semiclassical method is used. (author)

Storage of Maize in Purdue Improved Crop Storage (PICS) Bags.

Science.gov (United States)

Williams, Scott B; Murdock, Larry L; Baributsa, Dieudonne

2017-01-01

Interest in using hermetic technologies as a pest management solution for stored grain has risen in recent years. One hermetic approach, Purdue Improved Crop Storage (PICS) bags, has proven successful in controlling the postharvest pests of cowpea. This success encouraged farmers to use of PICS bags for storing other crops including maize. To assess whether maize can be safely stored in PICS bags without loss of quality, we carried out laboratory studies of maize grain infested with Sitophilus zeamais (Motshulsky) and stored in PICS triple bags or in woven polypropylene bags. Over an eight month observation period, temperatures in the bags correlated with ambient temperature for all treatments. Relative humidity inside PICS bags remained constant over this period despite the large changes that occurred in the surrounding environment. Relative humidity in the woven bags followed ambient humidity closely. PICS bags containing S. zeamais-infested grain saw a significant decline in oxygen compared to the other treatments. Grain moisture content declined in woven bags, but remained high in PICS bags. Seed germination was not significantly affected over the first six months in all treatments, but declined after eight months of storage when infested grain was held in woven bags. Relative damage was low across treatments and not significantly different between treatments. Overall, maize showed no signs of deterioration in PICS bags versus the woven bags and PICS bags were superior to woven bags in terms of specific metrics of grain quality.

Machine Shop Lathes.

Science.gov (United States)

Dunn, James

This guide, the second in a series of five machine shop curriculum manuals, was designed for use in machine shop courses in Oklahoma. The purpose of the manual is to equip students with basic knowledge and skills that will enable them to enter the machine trade at the machine-operator level. The curriculum is designed so that it can be used in…

Engineering work plan for container venting system drill press assembly troubleshooting. Revision 1

International Nuclear Information System (INIS)

Prather, M.C.

1994-11-01

This work plan is for troubleshooting the current CVS drill press to ensure that the drill bit assembly doesn't bind in the press plate. A drill press assembly has been fabricated for the Container Venting System (CVS). The drill bit assembly has bound in the press plate in previous revisions of this design. Initial troubleshooting of the drill press per Rev. 0 of this work plan was performed at the 200W Kaiser Machine Shop under Work Package 2H9401670F, Internal Work Order E20027. The drill press operated without jamming. Then, during the pre-operational test on 11/14/17 and the operational test on 11/17/94, two drum lids were drilled. Immediately after the test on 11/17/94, the drill was again operated, and it jammed. An inspection found shavings at the bottom of the drill bit assembly, between the drill bit sleeve and the press plate bore. This revised work plan provides direction for the machine shop to diagnose and correct this recent problem

49 CFR 178.521 - Standards for paper bags.

Science.gov (United States)

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Standards for paper bags. 178.521 Section 178.521...-bulk Performance-Oriented Packaging Standards § 178.521 Standards for paper bags. (a) The following are identification codes for paper bags: (1) 5M1 for a multi-wall paper bag; and (2) 5M2 for a multi-wall water...

Buying cannabis in 'coffee shops'.

Science.gov (United States)

Monshouwer, Karin; Van Laar, Margriet; Vollebergh, Wilma A

2011-03-01

The key objective of Dutch cannabis policy is to prevent and limit the risks of cannabis consumption for users, their direct environment and society ('harm reduction'). This paper will focus on the tolerated sale of cannabis in 'coffee shops'. We give a brief overview of Dutch policy on coffee shops, its history and recent developments. Furthermore, we present epidemiological data that may be indicative of the effects of the coffee shop policy on cannabis and other drug use. Dutch coffee shop policy has become more restrictive in recent years and the number of coffee shops has decreased. Cannabis prevalence rates in the adult population are somewhat below the European average; the rate is relatively high among adolescents; and age of first use appears to be low. On a European level, the use of hard drugs in both the Dutch adult and adolescent population is average to low (except for ecstasy among adults). International comparisons do not suggest a strong, upward effect of the coffee shop system on levels of cannabis use, although prevalence rates among Dutch adolescents give rise to concern. Furthermore, the coffee shop system appears to be successful in separating the hard and soft drugs markets. Nevertheless, in recent years, issues concerning the involvement of organised crime and the public nuisance related to drug tourism have given rise to several restrictive measures on the local level and have sparked a political debate on the reform of Dutch drug policy. © 2011 Trimbos Institute.

Kinect sensing of shopping related actions

NARCIS (Netherlands)

Popa, M.; Koc, A.K.; Rothkrantz, L.J.M.; Shan, C.; Wiggers, P.

2011-01-01

Surveillance systems in shopping malls or supermarkets are usually used for detecting abnormal behavior. We used the distributed video cameras system to design digital shopping assistants which assess the behavior of customers while shopping, detect when they need assistance, and offer their support

Social Sustainability of Shopping Streets in Ankara

Directory of Open Access Journals (Sweden)

Özge YALÇINER ERCOŞKUN

2013-02-01

Full Text Available Shopping streets are integral parts of public spaces in traditional shopping areas of Central Business Districts (CBD. Furthermore, as modern shopping venues, shopping centers offer advantages for modern lifestyles with spacious shopping areas, variety of commercial and social activities, and economic value of their investments. These advantages act in favor of shopping centers and improve the level of shopping street social sustainability and its relevant concepts. The aim of this study is to analyze the main shopping streets of Ankara, using the concepts of social sustainability. In this study, these concepts, such as locality, identity, vitality, viability, sense of place, conviviality, meaning and local characteristics of the shopping streets are investigated. For the first time, the retail unit locations in Ankara, their brands and their business types, are illustrated on thematic land use maps using Geographical Information Systems (GIS software. Next, population activities and consumer spatial behavior are observed and marked on maps that are also referred to as social sustainability maps. The results of the study can be useful in formulating strategies within the framework of social sustainability, which is a relatively new concept.

Nuclear surface vibrations in bag models

International Nuclear Information System (INIS)

Tomio, L.

1984-01-01

The main difficulties found in the hadron bag models are reviewed from the original version of the MIT bag model. Following, with the aim to answer two of the main difficulties in bag models, viz., the parity and the divergence illness, a dynamical model is presented. In the model, the confinement surface of the quarks (bag) is treated like a real physical object which interacts with the quarks and is exposed to vibrations. The model is applied to the nucleon, being observed that his spectrum, in the first excited levels, can be reproduced with resonable precision and obeying to the correct parity order. In the same way that in a similar work of Brown et al., it is observed to be instrumental the inclusion of the effect due to pions. (L.C.) [pt

Science Shops - a concept for community based learning

DEFF Research Database (Denmark)

Jørgensen, Michael Søgaard; Hende, Merete

2001-01-01

Experience from science shops show that besides assisting citizen groups, science shops can also contribute to the development of university curricula and research. The paper is based on an investigation of the impact of science shops on university curricula and research through a questionnaire...... sent out to science shops and through follow-up interviews with employees from nine different university based science shops. These science shops had in the questionnaire indicated that the science shop in one way or the other has had impact on university curricula and/or research. This paper focuses...... on the impact on university curricula. The case studies have been supplemented with articles and reports. The analysis has focused on the kind of impact, which the science shops have reported, and has tried to relate the impact to the local history of the science shop. One direct impact on the curricula...

Knife-edge seal for vacuum bagging

Science.gov (United States)

Rauschl, J. A.

1980-01-01

Cam actuated clamps pinch bagging material between long knife edge (mounted to clamps) and high temperature rubber cushion bonded to baseplate. No adhesive, tape, or sealing groove is needed to seal edge of bagging sheet against base plate.

Why Shops Close Again : An Evolutionary Perspective on the Deregulation of Shopping Hours

NARCIS (Netherlands)

Kosfeld, M.

1999-01-01

This paper introduces a new perspective on the deregulation of shopping hours based on ideas from evolutionary game theory. We study a retail economy where shopping hours have been deregulated recently. It is argued that first, the deregulation leads to a coordination problem between store owners

16 CFR 501.3 - Replacement bags for vacuum cleaners.

Science.gov (United States)

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Replacement bags for vacuum cleaners. 501.3... REQUIREMENTS AND PROHIBITIONS UNDER PART 500 § 501.3 Replacement bags for vacuum cleaners. Replacement bags for..., provided: (a) The quantity of contents is expressed in terms of numerical count of the bags; (b) A...

Hybrid job shop scheduling

NARCIS (Netherlands)

Schutten, Johannes M.J.

1995-01-01

We consider the problem of scheduling jobs in a hybrid job shop. We use the term 'hybrid' to indicate that we consider a lot of extensions of the classic job shop, such as transportation times, multiple resources, and setup times. The Shifting Bottleneck procedure can be generalized to deal with

Online Shopping In The UK

OpenAIRE

K. K. Ramachandran; K. K. Karthick; M. Saravana Kumar

2011-01-01

This paper will contribute to current academic literature in the area of online retailing and consumer behaviour. Our research outlines a survey conducted with respondents from the UK to ascertain their attitudes to grocery shopping both off and online. The findings indicate that, whilst the vast majority of our sample has experience of online shopping, few actively engage in online grocery shopping. Some of the reasons for this are highlighted and the key issues relate to consumer trust and ...

Shopping Online Sebagai Gaya Hidup

OpenAIRE

Lestari, Sri Budi

2015-01-01

The use of internet communication technology can make the world as if in one hand makes electronicbusiness with the concept of Online Shopping at its peak in recent years along with the development ofcommunication technologies over theInternet.How to shop online by using the internet through computers andmobile devices is increasingly popular smartphone can even be said to have become a trend today.Variousconvenience of shopping be the main thing to offer, with enough gadgets available in the...

The Shopping Mall: A Teenager Hangout.

Science.gov (United States)

Anthony, Kathryn H.

1985-01-01

Investigated teenagers' use of the shopping mall as a "hangout" through interviews with 51 adolescents using the mall, and 10 hours of behavioral observations. Results indicated that many teenagers visit the shopping center regularly to watch members of the opposite sex, play video games, see friends, shop, and people-watch. (Author/NRB)

Cross-border shopping and tourism destination marketing

DEFF Research Database (Denmark)

Makkonen, Teemu

2016-01-01

This article addresses the economic impact that cross-border shopping has on the local tourism industry and the ways that cross-border shopping is taken advantage of in tourism destination marketing. Southern Jutland–situated in Denmark just north of the German border, where border shops situated......-border shopping into tourism destination marketing strategies. The results have wider relevance for other border regions.......This article addresses the economic impact that cross-border shopping has on the local tourism industry and the ways that cross-border shopping is taken advantage of in tourism destination marketing. Southern Jutland–situated in Denmark just north of the German border, where border shops situated...... just south of the same border enable Danes to capitalize on the lower value added tax levels in Germany–is utilized as an illustrative case example. The data was collected by analysing the relevant tourism destination marketing material and via interviews with local destination marketing organizations...

Biodegradable bags for the production of plant seedlings

OpenAIRE

Bilck,Ana Paula; Olivato,Juliana Bonametti; Yamashita,Fabio; Souza,José Roberto Pinto de

2014-01-01

The production of plant seedlings has traditionally used polyethylene bags, which are thrown out in the soil or burned after transplant because the large amount of organic material attached to the bags makes recycling difficult. Additionally, when a seedling is taken from the bag for transplant, there is the risk of root damage, which compromises the plant’s development. In this study, we developed biodegradable bags to be used in seedling production, and we verify their influence on the deve...

Improved bag models of P-wave baryons

International Nuclear Information System (INIS)

Wang Fan; Wong Chunwa

1988-01-01

Problems in two previous bag-model calculations of P-wave baryon states are pointed out. The two-body matrix elements used in one of these models, the Myhrer-Wroldsen bag model, have now been revised and corrected by Myhrer, Umino and Wroldsen. We use their corrected matrix elements to construct simple bag models in which baryon masses are stabilized against collapse by using a finite pion size. We find that baryon masses in both ground and excited states can be fitted with the same model parameters. Models with small-bag baryons of the type proposed by Brown and Rho are then obtained. Typical bag radii are 0.5 fm for N, 0.6 fm for Δ and 0.7 fm for P-wave nonstrange baryons. In these models, the mixing angles are still unsatisfactory, while inadequacy in the treatment of center-of-mass motion found in an earlier paper persists. These results are briefly discussed. especially in connection with skyrmion models. (orig.)

Dynamic Support of Government in Online Shopping

OpenAIRE

Hai, Le Chi; Alam Kazmi, Syed Hasnain

2015-01-01

Advancements in online shopping for consumers requires consistent government support policies and the introduction of substantial government laws and regulations. In order to establish innovative developments in online shopping market environment that makes online shopping faster and stable, the government perspective is vital with the Technology Acceptance Model (TAM) for research and development in online shopping behavior for consumer’s confidence and their purchase intention. The proposed...

SHOPPING ONLINE SEBAGAI GAYA HIDUP

OpenAIRE

Sri Budi Lestari

2016-01-01

The use of internet communication technology can make the world as if in one hand makes electronic business with the concept of Online Shopping at its peak in recent years along with the development of communication technologies over theInternet.How to shop online by using the internet through computers and mobile devices is increasingly popular smartphone can even be said to have become a trend today.Various convenience of shopping be the main thing to offer, with enough gadgets ...

21 CFR 870.3650 - Pacemaker polymeric mesh bag.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Pacemaker polymeric mesh bag. 870.3650 Section 870...) MEDICAL DEVICES CARDIOVASCULAR DEVICES Cardiovascular Prosthetic Devices § 870.3650 Pacemaker polymeric mesh bag. (a) Identification. A pacemaker polymeric mesh bag is an implanted device used to hold a...

Wave energy absorption by a floating air bag

DEFF Research Database (Denmark)

Kurniawan, Adi; Chaplin, John; Greaves, Deborah

2017-01-01

A floating air bag, ballasted in water, expands and contracts as it heaves under wave action. Connecting the bag to a secondary volume via a turbine transforms the bag into a device capable of generating useful energy from the waves. Small-scale measurements of the device reveal some interesting...

Process Waste Assessment - Paint Shop

International Nuclear Information System (INIS)

Phillips, N.M.

1993-06-01

This Process Waste Assessment was conducted to evaluate hazardous wastes generated in the Paint Shop, Building 913, Room 130. Special attention is given to waste streams generated by the spray painting process because it requires a number of steps for preparing, priming, and painting an object. Also, the spray paint booth covers the largest area in R-130. The largest and most costly waste stream to dispose of is open-quote Paint Shop wasteclose quotes -- a combination of paint cans, rags, sticks, filters, and paper containers. These items are compacted in 55-gallon drums and disposed of as solid hazardous waste. Recommendations are made for minimizing waste in the Paint Shop. Paint Shop personnel are very aware of the need to minimize hazardous wastes and are continuously looking for opportunities to do so

BAG3: a multifaceted protein that regulates major cell pathways

Science.gov (United States)

Rosati, A; Graziano, V; De Laurenzi, V; Pascale, M; Turco, M C

2011-01-01

Bcl2-associated athanogene 3 (BAG3) protein is a member of BAG family of co-chaperones that interacts with the ATPase domain of the heat shock protein (Hsp) 70 through BAG domain (110–124 amino acids). BAG3 is the only member of the family to be induced by stressful stimuli, mainly through the activity of heat shock factor 1 on bag3 gene promoter. In addition to the BAG domain, BAG3 contains also a WW domain and a proline-rich (PXXP) repeat, that mediate binding to partners different from Hsp70. These multifaceted interactions underlie BAG3 ability to modulate major biological processes, that is, apoptosis, development, cytoskeleton organization and autophagy, thereby mediating cell adaptive responses to stressful stimuli. In normal cells, BAG3 is constitutively present in a very few cell types, including cardiomyocytes and skeletal muscle cells, in which the protein appears to contribute to cell resistance to mechanical stress. A growing body of evidence indicate that BAG3 is instead expressed in several tumor types. In different tumor contexts, BAG3 protein was reported to sustain cell survival, resistance to therapy, and/or motility and metastatization. In some tumor types, down-modulation of BAG3 levels was shown, as a proof-of-principle, to inhibit neoplastic cell growth in animal models. This review attempts to outline the emerging mechanisms that can underlie some of the biological activities of the protein, focusing on implications in tumor progression. PMID:21472004

Nonlinear cloudy bag model in the meson mean-field approximation

International Nuclear Information System (INIS)

Bunatyan, G.G.

1989-01-01

We investigate the cloudy bag model for the nucleon, including the essentially nonlinear interaction of the quarks with the meson field. From the boundary conditions, which guarantee the stability of the bag, we obtain equations for the size R of the bag, for the momentum p of the quarks, and for the mean pion field var-phi. We obtain an expression for the total energy E of the bag nucleon. By taking the appropriate averages of all the relations the calculations reduce to the case of a spherically symmetric bag. We show that in the general nonlinear cloudy bag model in question the equations for R, p, and var-phi have a simultaneous solution which corresponds to the absolute minimum of the bag energy E and, consequently, that there exists a stable equilibrium state of the bag nucleon

Baryon excitations in the bag model

International Nuclear Information System (INIS)

Jaffe, R.L.

1976-07-01

Two recent spectroscopic applications of the bag model are discussed. The first is a study of the place of multiquark states in meson and baryon spectroscopy, and the second is an attempt to sort out the P-wave baryon excitations in a bag model. 33 references

Better Physician's 'Black Bags'

Science.gov (United States)

1976-01-01

The "black bag" is outgrowth of astronaut monitoring technology from NASA's Johnson Space Center. Technically known as the portable medical status system, a highly advanced physician's "black bag" weighs less than 30 pounds, yet contains equipment for monitoring and recording vital signs, electrocardiograms, and electroencephalograms. Liquid crystal displays are used to present 15 digits of data simultaneously for long periods of time without excessive use of battery power. Single printed circuit card contains all circuitry required to measure and display vital signs such as heart and respiration rate, temperature, and blood pressure.

Youth Clothes-Shopping Behavior: An Analysis by Gender.

Science.gov (United States)

Peters, John F.

1989-01-01

Explored possible gender differences in clothes-shopping behavior among adolescents. Findings from 387 college students revealed that: parents financially assisted sons and daughters equally; there was no gender difference in shopping frequency; mothers more frequently shopped with sons than with daughters; fathers rarely shopped with any…

The quark mass and baryon numbers of empty chiral bags

International Nuclear Information System (INIS)

Jezabek, M.; Zalewski, K.

1984-01-01

We show that for spherical chiral bags the baryon number of the Dirac vacuum inside the bag does not depend on quark masses. Thus, the sum of the baryon numbers of an empty chiral bag and the skyrmion surrounding the bag is an integer, which depends on the boundary condition on the surface of the bag. This extends the result obtained by Goldstone and Jaffe for massless quarks. (orig.)

BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta

Science.gov (United States)

Minoia, Melania; Boncoraglio, Alessandra; Vinet, Jonathan; Morelli, Federica F; Brunsting, Jeanette F; Poletti, Angelo; Krom, Sabine; Reits, Eric; Kampinga, Harm H; Carra, Serena

2014-01-01

Eukaryotic cells use autophagy and the ubiquitin–proteasome system as their major protein degradation pathways. Upon proteasomal impairment, cells switch to autophagy to ensure proper clearance of clients (the proteasome-to-autophagy switch). The HSPA8 and HSPA1A cochaperone BAG3 has been suggested to be involved in this switch. However, at present it is still unknown whether and to what extent BAG3 can indeed reroute proteasomal clients to the autophagosomal pathway. Here, we show that BAG3 induces the sequestration of ubiquitinated clients into cytoplasmic puncta colabeled with canonical autophagy linkers and markers. Following proteasome inhibition, BAG3 upregulation significantly contributes to the compensatory activation of autophagy and to the degradation of the (poly)ubiquitinated proteins. BAG3 binding to the ubiquitinated clients occurs through the BAG domain, in competition with BAG1, another BAG family member, that normally directs ubiquitinated clients to the proteasome. Therefore, we propose that following proteasome impairment, increasing the BAG3/BAG1 ratio ensures the “BAG-instructed proteasomal to autophagosomal switch and sorting” (BIPASS). PMID:25046115

Toponium Tests Of Top-Quark Higgs Bags

OpenAIRE

Macpherson, Alick L.; Campbell, Bruce A.

1993-01-01

Recently it has been suggested that top quarks, or very massive fourth generation quarks, might surround themselves with a Higgs "bag" of deformation of the Higgs expectation value from its vacuum magnitude. In this paper we address the question of whether such nonlinear Higgs-top interaction effects are subject to experimental test. We first note that if top quarks were necessarily accompanied by Higgs "bags", then top quark weak decay would involve the sudden disruption of the Higgs "bag", ...

Consumers preferences of shopping centers in Bratislava (Slovakia

Directory of Open Access Journals (Sweden)

Kristína Bilková

2016-05-01

Full Text Available There have been changes in the shopping behavior and preferences of consumers in the post-communist countries caused by political changes after 1989. Slovakia is not an exception, and it has been observed a change not only at the consumers’ level but also in retail stores. A notable bearer of such changes was the construction of big shopping centers that were a new phenomenon in shopping. They quickly became popular and changed spatial and shopping patterns of consumers. The main aim of this study is to analyze and evaluate the shopping preferences of consumers based on the example of the capital city – Bratislava (at the level of urban districts. The database consists of results of a questionnaire survey carried out in 2011. Respondents were interviewed inside the shopping center. The partial aims focus on the analysis of consumers’ perceptions, the frequency of their shopping and the mode of transport used for shopping. One of the goals of this study is also to evaluate the perception of consumers in terms of the catchment areas of the chosen shopping center, as well as the perceptional classification of retail in the given area and the accessibility of stores.

Strategy of image management in retail shops

Directory of Open Access Journals (Sweden)

Sandra Soče Kraljević

2007-12-01

Full Text Available A sound positioning in consumers’ mind, along with strong promotion support, brought many retail shops to the top. This is mostly thanks to the image created in the consumers’ mind. A retail shop’s image may but need not conform to reality. Image often looks like a cliché. It overstates certain elements of the shop while simply omitting others. That is exactly why image is of great importance and often crucial to consumer behavior. This paper aims at determining the impact of image on customer behavior in the course of decision making about shopping and choosing a particular retail shop. Image is a significant factor of success of every company, hence also of a retail shops. It is a relatively strong value and a component of creating competitive advantage. But if we do not pay sufficient attention to image, it can become counterproductive. Instead to, like an additional value helps creating and maintaining the advantage in competition and realization of business aims, transforms into a limiting factor. Therefore, it is imperative to identify the elements of image that are of greatest importance to customers. Research has shown that customers choose the retail shop first and after that products and brands within this shop. When it comes to the supermarket, as a kind of retail shop, research has shown that two out of three shopping decisions are made by the customer on the spot, that is, without previous planning. That practically means that we can influence customers with different sales techniques. The paper suggests different strategies of image management for supermarkets and conventional shops. For supermarkets it is the “widest assortment” strategy, while for conventional shops the strategy is that of a “selected group of products“. Improvements to research methods will enable getting more information about customer behavior, while pressures of increased competition in the business environment will force retailers to get

49 CFR 178.520 - Standards for textile bags.

Science.gov (United States)

2010-10-01

..., plastic film bonded to the inner surface of the bag, or one or more inner liners made of paper or plastic... bag, or one or more inner liners made of plastic material or metalized film or foil. (4) Maximum net... 49 Transportation 2 2010-10-01 2010-10-01 false Standards for textile bags. 178.520 Section 178...

Stability of Fentanyl Citrate in Polyolefin Bags.

Science.gov (United States)

Donnelly, Ronald F

2016-01-01

Fentanyl is used to manage pain because it is a potent lipophilic opiate agonist. The stability of fentanyl in polyolefin bags when diluted to either 10 µg/mL or 50 µg/mL with sodium chloride 0.9% has not been studied. The chemical stability of fentanyl 50 µg/mL packaged in polyvinyl chloride bags has been studied, however, the stability in polyolefin bags is lacking. Polyolefin bags were aseptically filled with either 10-µg/mL or 50-µg/mL fentanyl solution. Containers were then stored at either 5°C and protected from light or 22°C and exposed to light for 93 days. Fentanyl peaks were monitored using a stability-indicatin high-performance liquid chromatographic method. Changes to color, clarity, and pH were also monitored. There were no signs of chemical degradation of fentanyl packaged in polyolefin bags at either 5°C or 22°C after storage for 93 days. Over the course of the study, all solutions remained colorless and clear. The pH showed a slight decrease during the 93 days of storage. The stability of both undiluted (50-µg/mL) and diluted (10-µg/mL) fentanyl solutions when packaged in polyolefin bags was 93 days when stored at either 5°C or 22°C. Copyright© by International Journal of Pharmaceutical Compounding, Inc.

Solid and Liquid Waste Drying Bag

Science.gov (United States)

Litwiller, Eric (Inventor); Hogan, John A. (Inventor); Fisher, John W. (Inventor)

2009-01-01

Method and system for processing waste from human activities, including solids, liquids and vapors. A fluid-impermeable bag, lined with a liquid-impermeable but vapor-permeable membrane, defining an inner bag, is provided. A vacuum force is provided to extract vapors so that the waste is moved toward a selected region in the inner bag, extracted vapors, including the waste vapors and vaporized portions of the waste liquids are transported across the membrane, and most or all of the solids remain within the liner. Extracted vapors are filtered, and sanitized components thereof are isolated and optionally stored. The solids remaining within the liner are optionally dried and isolated for ultimate disposal.

BAG3 is involved in neuronal differentiation and migration.

Science.gov (United States)

Santoro, Antonietta; Nicolin, Vanessa; Florenzano, Fulvio; Rosati, Alessandra; Capunzo, Mario; Nori, Stefania L

2017-05-01

Bcl2-associated athanogene 3 (BAG3) protein belongs to the family of co-chaperones interacting with several heat shock proteins. It plays a key role in protein quality control and mediates the clearance of misfolded proteins. Little is known about the expression and cellular localization of BAG3 during nervous system development and differentiation. Therefore, we analyze the subcellular distribution and expression of BAG3 in nerve-growth-factor-induced neurite outgrowth in PC12 cells and in developing and adult cortex of mouse brain. In differentiated PC12 cells, BAG3 was localized mainly in the neuritic domain rather than the cell body, whereas in control cells, it appeared to be confined to the cytoplasm near the nuclear membrane. Interestingly, the change of BAG3 localization during neuronal differentiation was associated only with a slight increase in total BAG3 expression. These data were coroborated by transmission electron microscopy showing that BAG3 was confined mainly within large dense-core vesicles of the axon in differentiated PC12 cells. In mouse developing cortex, BAG3 appeared to be intensely expressed in cellular processes of migrating cells, whereas in adult brain, a diffuse expression of low to medium intensity was detected in neuronal cell bodies. These findings suggest that BAG3 expression is required for neuronal differentiation and migration and that its role is linked to a change in its distribution pattern rather than to an increase in its protein expression levels.

Degradation of plastic compost bags used for yard waste

International Nuclear Information System (INIS)

Taber, H.G.; Cox, D.F.

1993-01-01

Three trials, beginning June, July, and September 1991, examined the breakdown of photodegradable plastic bags. The plastic contained a light-sensitive compound dissolved in the polymer to hasten degradation. The bags were placed in east-west rows on bare ground. Other factors studied included turning the bags over either every 3 or 7 days and either filling the bags with fresh grass clippings or leaving them empty. Strength loss was determined with a hand-held puncture tester. Strength increased initially by 36%, 32%, and 63% in the three trials, respectively. The bags took 33, 35, and 64 days to reach brittleness (puncture strength of 180 g) in the three trials, respectively. Once degradation began, all trials showed similar rates of decline. However, the degradation began 7 days after exposure in the first two trials, but not until 14 days after exposure in the September trial. The addition of grass clippings to the bags increased the initial strength and delayed the onset of degradation. Turning the bags every 3 days rather than every 7 did not affect degradation

CERN Shop - Christmas Sale in Bldg. 33

CERN Multimedia

PH Department

2010-01-01

Looking for Christmas present ideas? The CERN Shop will give CERN card holders a special reduction of 10 % on all CERN Shop articles from Monday 13.12.2010 to Saturday 18.12.2010. Come and visit the CERN Shop in the Reception Building 33.

Ellipsoidal bag model for heavy quark system

International Nuclear Information System (INIS)

Bi Pinzhen; Fudan Univ., Shanghai

1991-01-01

The ellipsoidal bag model is used to describe heavy quark systems such as Qanti Q, Qanti Qg and Q 2 anti Q 2 . Instead of two step model, these states are described by an uniform picture. The potential derived from the ellipsoidal bag for Qanti Q is almost equivalent to the Cornell potential. For a Q 2 anti Q 2 system with large quark pair separation, an improvement of 70 MeV is obtained comparing with the spherical bag. (orig.)

Marketing plan for a web shop business

OpenAIRE

Koskivaara, Leonilla

2014-01-01

Internet has changed the buying behavior of consumers during the past years and companies need to adapt to the changes. Web shop business is an important sales channel of today’s companies. Advantages of a web shop business include cost effectiveness and potential to do business globally. Challenges of a web shop business include search engine optimization and running both, a retail store and a web shop at the same time. Social media has become an important marketing channel and has bec...

Comparison of the risks of shopping behavior and opioid abuse between tapentadol and oxycodone and association of shopping behavior and opioid abuse.

Science.gov (United States)

Cepeda, M Soledad; Fife, Daniel; Kihm, Mary A; Mastrogiovanni, Greg; Yuan, Yingli

2014-12-01

This study compared the risks of opioid shopping behavior and opioid abuse between tapentadol immediate release and oxycodone immediate release and, to validate the definition of shopping, examined the association between opioid shopping and opioid abuse further. This retrospective cohort study using linked dispensing and diagnosis databases followed opioid-naive patients for development of shopping behavior and/or opioid abuse during 1 year after initial exposure to tapentadol or oxycodone. Shopping was defined by having overlapping opioid prescriptions from >1 prescriber filled at ≥3 pharmacies; abuse by having International Classification of Diseases, 9th revision diagnoses reflecting opioid abuse, addiction, or dependence. To determine their association, we cross-tabulated shopping and opioid abuse and calculated odds ratios. Risks of developing each outcome were estimated using logistic regression. Among 277,401 participants initiating opioid use with tapentadol (39,524) or oxycodone (237,877), 0.6% developed shopping behavior, 0.75% developed abuse. Higher proportions of patients in the oxycodone group developed shopping behavior and abuse than in the tapentadol group (shopping: adjusted odds ratio [95% confidence interval], 0.45 [0.36-0.55]; abuse: 0.44 [0.37-0.54]). Shopping behavior and abuse were associated; of those with shopping behavior, 6.5% had abuse. Age (18 to 64 y), sex (male), prior benzodiazepine use, paying cash, and history (mood disorders, abuse of nonopioid medications, and back pain) were risk factors for developing either outcome. Shopping behavior and abuse measure complementary, but associated, constructs, which further validates the current definition of shopping. The risk of developing either is lower among patients who initiate opioid use with tapentadol than those who initiate opioid use with oxycodone.

Shop stewards' learning and union strategies

DEFF Research Database (Denmark)

Warring, Niels

2007-01-01

In Denmark the trade unions have well established educational systems providing the shop stewards with a variety of competencies. Union courses have been analysed focusing on shop stewards' satisfaction with the content and the practical impact of the courses. However, little attention has been...... different theoretical traditions: Shop steward's learning is situational, relational and cross-contextual. Shop stewards' learning is lifelong and life wide. And shop stewards' learning is closely connected to the development of the labour market and not least the unions' priorities, interpretation...

Sourav Bag

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences. Sourav Bag. Articles written in Journal of Chemical Sciences. Volume 128 Issue 3 March 2016 pp 339-347 Regular Articles. On the electrocatalytic activity of nitrogen-doped reduced graphene Oxide:Does the nature of nitrogen really control the activity towards oxygen ...

Why do you shop there? A mixed methods study mapping household food shopping patterns onto weekly routines of black women.

Science.gov (United States)

DiSantis, Katherine Isselmann; Hillier, Amy; Holaday, Rio; Kumanyika, Shiriki

2016-01-28

The effectiveness of initiatives to increase healthy food access may be affected by where people decide to shop. People with poor neighborhood access to large grocery stores develop shopping patterns that require traveling to other areas, and some people who do have neighborhood access also travel elsewhere for food shopping. We sought to gain an understanding of household food shopping patterns in a sample of Black women in terms of where they shopped and why. All food shopping trips of 35 low- or middle/high-income black mothers or caregivers living with at least one child were identified from grocery shopping receipts collected over four consecutive weeks. Food shopping locations were mapped along with locations of participants' homes and other places they visited during weekly routine travels (e.g. work, child's school). Semi-structured individual interviews elicited narrative information about whether and how grocery shopping trips were linked to routine travels. Inductive content analysis was utilized to identify emergent themes from interviews. Themes were considered in relation to geospatial distances and travel patterns identified through mapping of participants' shopping. Participants shopped at an average of six different stores, traveling on average a total of 35 miles (sd = 41) (Euclidian distance) over the four weeks. The most frequented store was within a mile of home (57%) or home or another place visited in the weekly routine for about 77% of participants. Interview results emphasized the concept of convenience which referred to geographical proximity to the home or routine destinations and also to potential to save time because several stores were co-located or because the store layout was easy to navigate and familiar. Store selection also related to mode of transportation, pricing, and family preference for certain foods. People have specific reasons for consistently shopping in areas outside of their neighborhood of residence. Incorporating

Waste Management Policy Implementation in South Africa: An ...

African Journals Online (AJOL)

The need to eliminate plastic shopping bags from South Africa's environment has resulted in the formation and implementation of the Plastic Carrier Bags and Plastics Flat Bags Regulations (hereafter referred to as the Plastic Bags Regulations).The new law requires manufacturers to produce thicker, reusable and ...

Marketing activities of vape shops across racial/ethnic communities.

Science.gov (United States)

Garcίa, Robert; Sidhu, Anupreet; Allem, Jon-Patrick; Baezconde-Garbanati, Lourdes; Unger, Jennifer B; Sussman, Steve

2016-01-01

There has been a surge in the number of vape shops in the USA. Research on the marketing practices of e-cigarette manufacturers is scarce and even less known are the practices of vape shop retailers. Past research on tobacco marketing has shown differences in the amount and content of marketing material, based on a community's demographic profile. This study examined marketing strategies in vape shops and explored differences among vape shops located in communities that differ by ethnic composition. Data was gathered in 2014 from a pilot-study on vape shops (n=77) in Los Angeles, which documented the characteristics of shops through employee interviews and in-store observations. Data were collected from shops located in communities that were predominantly, African-American (n=20), Hispanic (n=17), Korean (n=18), or non-Hispanic White (n=22). Sixty-one percent of vape shops had advertisements (print ads and posters) for e-cigarettes and 84% offered discounts. Vape shops in Hispanic communities were more likely to have ethnic specific marketing material compared to shops in other communities. All the shops provided customers with free samples, however those in Korean and non-Hispanic White communities had a significantly higher prevalence of customer accessible free samples. Vape shop marketing practices differed by ethnic community. A large majority of shops provided free samples to their customers, a practice which is now banned by the FDA. It will be important to monitor how vape shops will adjust their marketing strategy because of this ban. Future research should expand on the findings presented here to provide regulators with further crucial information.

CERN Shop - Christmas Sale in Bldg. 33

CERN Multimedia

PH Department

Looking for Christmas present ideas? The CERN Shop will give the CERN card holders a special reduction of 10 % on all CERN Shop articles from Friday 11.12.2009 to Thursday 17.12.2009. Come to visit the CERN Shop at the Reception, Building 33. PH-EDU-PO

Reflexivity in performative science shop projects

OpenAIRE

Beunen, R.; Duineveld, M.; During, R.; Straver, G.H.M.B.; Aalvanger, A.

2012-01-01

Science shop research projects offer possibilities for universities to engage with communities. Many science shop projects directly or indirectly intend to empower certain marginalised groups or interests within a decision-making process. In this article we argue that it is important to reflect on the role and position the researchers have in these projects. We present three science shop projects to illustrate some of the dilemmas that may arise in relation to citizen empowerment, democracy, ...

Handbook for Trade and Industrial Shop Teachers.

Science.gov (United States)

Texas A and M Univ., College Station. Vocational Instructional Services.

This handbook is intended to help teachers of pre-employment shop courses in organizing and delivering instruction in both the shop and classroom. Addressed in the guide are the following topics: the instructor's place in the local school organization; the instructor's job (objectives, advisory committees, occupational analysis, shop/classroom and…

Properties of the cloudy bag in nuclear matter

International Nuclear Information System (INIS)

Bunatyan, G.G.

1986-01-01

Because of the pion mode softening, the pion field of the clody bag in the nuclear matter increases if the nuclear density increases. This causes in its turn the decreasing of the bag size and at a sufficiently large density of the nuclear matter lead to absolute instability of the cloudy bag-nucleon, which means the transition of the nuclear matter in another nonnucleon phase

Dimensions of Consumer's Perceived Risk in Online Shopping

Institute of Scientific and Technical Information of China (English)

YE Naiyi

2004-01-01

Perceived risk is an important concept in consumer behavior in online shopping. It impedes the adopting online shopping. A structure model with seven factors of consumer's perceived risk in online shopping is developed in this paper. The results have the descriptive power about Chinese consumers' perceived risk in Internet shopping and provide framework for managerial use in China's e-commerce market environment.

Ammonia Diffusion through Nalophan Double Bags: Effect of Concentration Gradient Reduction

Science.gov (United States)

Capelli, Laura; Boiardi, Emanuela; Del Rosso, Renato

2014-01-01

The ammonia loss through Nalophan bags has been studied. The losses observed for storage conditions and times as allowed by the reference standard for dynamic olfactometry (EN 13725:2003) indicate that odour concentration values due to the presence of small molecules may be significantly underestimated if samples are not analysed immediately after sampling. A diffusion model was used in order to study diffusion through the bag. The study discusses the effect of concentration gradient (ΔC) across the polymeric membrane of the analyte. The ΔC was controlled by using a setup bag called “double bags.” Experimental data show a reduction of ammonia percentage losses due to the effect of the external multibarrier. The expedient of the double bag loaded with the same gas mixture allows a reduced diffusion of ammonia into the inner bag. Comparing the inner bag losses with those of the single bag stored in the same conditions (T, P, u) and with equal geometrical characteristics (S/V, z), it was observed that the inner bag of the double bag displays a 16% loss while the single bag displays a 37% loss. Acting on the ΔC it is possible to achieve a gross reduction of 57% in the ammonia leakage due to diffusion. PMID:25506608

Ammonia diffusion through Nalophan double bags: effect of concentration gradient reduction.

Science.gov (United States)

Sironi, Selena; Eusebio, Lidia; Capelli, Laura; Boiardi, Emanuela; Del Rosso, Renato

2014-01-01

The ammonia loss through Nalophan bags has been studied. The losses observed for storage conditions and times as allowed by the reference standard for dynamic olfactometry (EN 13725:2003) indicate that odour concentration values due to the presence of small molecules may be significantly underestimated if samples are not analysed immediately after sampling. A diffusion model was used in order to study diffusion through the bag. The study discusses the effect of concentration gradient (ΔC) across the polymeric membrane of the analyte. The ΔC was controlled by using a setup bag called "double bags." Experimental data show a reduction of ammonia percentage losses due to the effect of the external multibarrier. The expedient of the double bag loaded with the same gas mixture allows a reduced diffusion of ammonia into the inner bag. Comparing the inner bag losses with those of the single bag stored in the same conditions (T, P, u) and with equal geometrical characteristics (S/V, z), it was observed that the inner bag of the double bag displays a 16% loss while the single bag displays a 37% loss. Acting on the ΔC it is possible to achieve a gross reduction of 57% in the ammonia leakage due to diffusion.

Forecasting of indirect consumables for a Job Shop

Science.gov (United States)

Shakeel, M.; Khan, S.; Khan, W. A.

2016-08-01

A job shop has an arrangement where similar machines (Direct consumables) are grouped together and use indirect consumables to produce a product. The indirect consumables include hack saw blades, emery paper, painting brush etc. The job shop is serving various orders at a particular time for the optimal operation of job shop. Forecasting is required to predict the demand of direct and indirect consumables in a job shop. Forecasting is also needed to manage lead time, optimize inventory cost and stock outs. The objective of this research is to obtain the forecast for indirect consumables. The paper shows how job shop can manage their indirect consumables more accurately by establishing a new technique of forecasting. This results in profitable use of job shop by multiple users.

Social image of students who shop and don't shop online.

Science.gov (United States)

Lammers, H Bruce; Curren, Mary T; Cours, Deborah; Lammers, Marilyn L

2003-06-01

A descriptive survey of a stratified random sample of 326 undergraduates from a large, diverse university in Los Angeles was conducted to assess whether resistance to online shopping might be, in part, related to negative social perceptions of those who shop online. Indirect questioning showed that students perceived online student shoppers as more lazy and less likely to fear for the safety and security of others but also as more trustworthy, attractive, successful, and smart. Differences in social perceptions were not related to these students' own online spending.

INDONESIAN CUSTOMER SATISFACTION IN ONLINE SHOPPING TRADING

Directory of Open Access Journals (Sweden)

Hermawan F.

2018-03-01

Full Text Available This research aims to find out if the ease of shopping, site design, informative, comprehensive, and communication have a significant influence on the level of Indonesian customer satisfaction in online shopping transactions and how the impact to the word of mouth communication. Respondents of this study are the 250 students of Jakarta colleges. This study found that the variables of design, simplicity, and security have an influence on customer satisfaction in shopping online, while the informative variable and communication have no influence on the customer's satisfaction online shopping.

BAG3 affects the nucleocytoplasmic shuttling of HSF1 upon heat stress

International Nuclear Information System (INIS)

Jin, Young-Hee; Ahn, Sang-Gun; Kim, Soo-A.

2015-01-01

Bcl2-associated athoanogene (BAG) 3 is a member of the co-chaperone BAG family. It is induced by stressful stimuli such as heat shock and heavy metals, and it regulates cellular adaptive responses against stressful conditions. In this study, we identified a novel role for BAG3 in regulating the nuclear shuttling of HSF1 during heat stress. The expression level of BAG3 was induced by heat stress in HeLa cells. Interestingly, BAG3 rapidly translocalized to the nucleus upon heat stress. Immunoprecipitation assay showed that BAG3 interacts with HSF1 under normal and stressed conditions and co-translocalizes to the nucleus upon heat stress. We also demonstrated that BAG3 interacts with HSF1 via its BAG domain. Over-expression of BAG3 down-regulates the level of nuclear HSF1 by exporting it to the cytoplasm during the recovery period. Depletion of BAG3 using siRNA results in reduced nuclear HSF1 and decreased Hsp70 promoter activity. BAG3 in MEF(hsf1 −/− ) cells actively translocalizes to the nucleus upon heat stress suggesting that BAG3 plays a key role in the processing of the nucleocytoplasmic shuttling of HSF1 upon heat stress. - Highlights: • The expression level of BAG3 is induced by heat stress. • BAG3 translocates to the nucleus upon heat stress. • BAG3 interacts with HSF1 and co-localizes to the nucleus. • BAG3 is a key regulator for HSF1 nuclear shuttling

BAG3 affects the nucleocytoplasmic shuttling of HSF1 upon heat stress

Energy Technology Data Exchange (ETDEWEB)

Jin, Young-Hee [Department of Biochemistry, Dongguk University College of Oriental Medicine, Gyeongju 780-714 (Korea, Republic of); Ahn, Sang-Gun [Department of Pathology, Chosun University College of Dentistry, Gwangju 501-759 (Korea, Republic of); Kim, Soo-A., E-mail: ksooa@dongguk.ac.kr [Department of Biochemistry, Dongguk University College of Oriental Medicine, Gyeongju 780-714 (Korea, Republic of)

2015-08-21

Bcl2-associated athoanogene (BAG) 3 is a member of the co-chaperone BAG family. It is induced by stressful stimuli such as heat shock and heavy metals, and it regulates cellular adaptive responses against stressful conditions. In this study, we identified a novel role for BAG3 in regulating the nuclear shuttling of HSF1 during heat stress. The expression level of BAG3 was induced by heat stress in HeLa cells. Interestingly, BAG3 rapidly translocalized to the nucleus upon heat stress. Immunoprecipitation assay showed that BAG3 interacts with HSF1 under normal and stressed conditions and co-translocalizes to the nucleus upon heat stress. We also demonstrated that BAG3 interacts with HSF1 via its BAG domain. Over-expression of BAG3 down-regulates the level of nuclear HSF1 by exporting it to the cytoplasm during the recovery period. Depletion of BAG3 using siRNA results in reduced nuclear HSF1 and decreased Hsp70 promoter activity. BAG3 in MEF(hsf1{sup −/−}) cells actively translocalizes to the nucleus upon heat stress suggesting that BAG3 plays a key role in the processing of the nucleocytoplasmic shuttling of HSF1 upon heat stress. - Highlights: • The expression level of BAG3 is induced by heat stress. • BAG3 translocates to the nucleus upon heat stress. • BAG3 interacts with HSF1 and co-localizes to the nucleus. • BAG3 is a key regulator for HSF1 nuclear shuttling.

PVC posting bags for glove boxes

International Nuclear Information System (INIS)

1976-12-01

This specification covers the materials, measurements and manufacture of unpigmented PVC posting bags for use on glove boxes, together with methods of testing the materials. These bags are used in the handling of radioactive and toxic materials of a hazardous nature and therefore must be of the highest standard of mechanical strength, leak tightness and general finish. (author)

Space Odyssey Gift Shop

Science.gov (United States)

2000-01-01

The Space Odyssey Gift Shop located in StenniSphere at the John C. Stennis Space Center in Hancock County, Miss., offers every visitor the opportunity to go home with 'the right stuff' from his or her StenniSphere visit. The gift shop is located just inside the front doors to StenniSphere and offers a wide range of space-related apparel, memorabilia, toys, books, mission patches and more.

Translational invariance in bag model

International Nuclear Information System (INIS)

Megahed, F.

1981-10-01

In this thesis, the effect of restoring the translational invariance to an approximation to the MIT bag model on the calculation of deep inelastic structure functions is investigated. In chapter one, the model and its major problems are reviewed and Dirac's method of quantisation is outlined. This method is used in chapter two to quantise a two-dimensional complex scalar bag and formal expressions for the form factor and the structure functions are obtained. In chapter three, the expression for the structure function away from the Bjorken limit is studied. The corrections to the L 0 - approximation to the structure function is calculated in chapter four and it is shown to be large. Finally, in chapter five, a bag-like model for kinematic corrections to structure functions is introduced and agreement with data between 2 and 6 (GeV/C) 2 is obtained. (author)

BAG3 controls angiogenesis through regulation of ERK phosphorylation.

Science.gov (United States)

Falco, A; Festa, M; Basile, A; Rosati, A; Pascale, M; Florenzano, F; Nori, S L; Nicolin, V; Di Benedetto, M; Vecchione, M L; Arra, C; Barbieri, A; De Laurenzi, V; Turco, M C

2012-12-13

BAG3 is a co-chaperone of the heat shock protein (Hsp) 70, is expressed in many cell types upon cell stress, however, its expression is constitutive in many tumours. We and others have previously shown that in neoplastic cells BAG3 exerts an anti-apoptotic function thus favoring tumour progression. As a consequence we have proposed BAG3 as a target of antineoplastic therapies. Here we identify a novel role for BAG3 in regulation of neo-angiogenesis and show that its downregulation results in reduced angiogenesis therefore expanding the role of BAG3 as a therapeutical target. In brief we show that BAG3 is expressed in endothelial cells and is essential for the interaction between ERK and its phosphatase DUSP6, as a consequence its removal results in reduced binding of DUSP6 to ERK and sustained ERK phosphorylation that in turn determines increased levels of p21 and p15 and cell-cycle arrest in the G1 phase.

Determinants Of Online Shopping In Manado

OpenAIRE

Halim, Ellen

2013-01-01

Retailers utilize online media to reach more potential customers. Internet connects the retailer and customers without any geographic location boundaries. Internet growth has a positive impact for business world. There is a new shopping method in non-store shopping as people can buy products or services without having to travel to the outlets like traditional retail does. With the increase of online retailers on internet world, online shopping became popular. The objective of this research is...

Potential of Natural Ventilation in Shopping Centres

DEFF Research Database (Denmark)

Diederichsen, Alice; Friis, Kristina; Brohus, Henrik

2008-01-01

The indoor environmental quality (IEQ) is a fundamental requirement for a well performing shopping centre. This paper contains a pilot study of the potential of using hybrid ventilation (a combination of automatically controlled natural and mechanical ventilation - respectively NV and MV) in shop......The indoor environmental quality (IEQ) is a fundamental requirement for a well performing shopping centre. This paper contains a pilot study of the potential of using hybrid ventilation (a combination of automatically controlled natural and mechanical ventilation - respectively NV and MV......) in shopping centres with focus on both the achieved IEQ and energy consumptions for air movement. By thermal building simulations it is found that there exists an interesting potential for hybrid ventilation of shopping centres, which can lead to great savings in the electrical energy consumptions...

Vector meson decays in the chiral bag model

International Nuclear Information System (INIS)

Maxwell, O.V.; Jennings, B.K.

1985-01-01

Vector meson decays are examined in a model where a confined quark and antiquark annihilate, producing a pair of elementary pseudoscalar mesons. Two versions of the pseudoscalar meson-quark interaction are employed, one where the coupling is restricted to the bag surface and one where it extends throughout the bag volume. Energy conservation is ensured in the model through insertion of exponential factors containing the bag energy at each interaction vertex. To guarantee momentum conservation, a wave-packet description is utilized in which the decay widths are normalized by a factor involving the overlap of the initial bag state with the confined qanti q state of zero momentum. With either interaction, the model yields a value for the p-width that exceeds the empirical width by a factor two. For the Ksup(*) and PHI mesons, the computed widths depend strongly on the interaction employed. Implications of these results for chiral bag models are discussed. (orig.)

HESITANCY TOWARDS ONLINE SHOPPING, A STUDY OF PAKISTANI CONSUMERS

Directory of Open Access Journals (Sweden)

Usman YOUSAF

2012-01-01

Full Text Available To study the influence of Perceived cost, risk, convenience and enjoyment on online consumer purchases. Being more convenient online shopping seems painless compared to in store shopping, why consumers are still reluctant to shop online?.A sample of 220 questionnaires was filled from different departments at University of Sargodha. Respondents were asked to fill the questionnaire based on four factors (Perceived cost, Perceived risk, Perceived convenience, Perceived enjoyment, there were 2 general questions. Out of 220, 207 questionnaires were returned. One sample test is applied in this study to check the reliability of independent variables. Analysis was also done on basis of gender and their ages. The most important factor out of four, which can persuade the customer's online buying decision, is delivery cost for purchased items and it has negative relationship with dependent variable, moreover perceived risk has also negative relationship with dependent one. Perceived convenience and Perceived enjoyment has positive relationship with online shopping preference. As online shopping is easier to do but due to extra delivery cost and risk factors consumers do not adopt online shopping and these factors should be minimized to promote online shopping. Online shopping should be promoted and to gain the consumer confidence, delivery cost and risk factor should be minimized. As online shopping is easier to do as compared to offline shopping but people still reluctant to use internet for online shopping, so to promote online shopping delivery cost and risk factor should be minimized to gain consumers attraction and confidence. People want to experience online shopping but it won’t be promoted until delivery cost and perceived risk factors be reduced. A little work has been done on exploring the factors that influence the online buying decision. These factors are called situational factors and include delivery charges, risk factors, convenience

Impact of storage environment on the efficacy of hermetic storage bags.

Science.gov (United States)

Lane, Brett; Woloshuk, Charles

2017-05-01

Small hermetic bags (50 and 100 kg capacities) used by smallholder farmers in several African countries have proven to be a low-cost solution for preventing storage losses due to insects. The complexity of postharvest practices and the need for ideal drying conditions, especially in the Sub-Sahara, has led to questions about the efficacy of the hermetic bags for controlling spoilage by fungi and the potential for mycotoxin accumulation. This study compared the effects of environmental temperature and relative humidity at two locations (Indiana and Arkansas) on dry maize (14% moisture content) in woven polypropylene bags and Purdue Improved Crop Storage (PICS) hermetic bags. Temperature and relative humidity data loggers placed in the middle of each bag provided profiles of environmental influences on stored grain at the two locations. The results indicated that the PICS bags prevented moisture penetration over the three-month storage period. In contrast, maize in the woven bags increased in moisture content. For both bag types, no evidence was obtained indicating the spread of Aspergillus flavus from colonized maize to adjacent non-colonized maize. However, other storage fungi did increase during storage. The number of infected kernels did not increase in the PICS bags, but the numbers in the woven bags increased significantly. The warmer environment in Arkansas resulted in significantly higher insect populations in the woven bags than in Indiana. Insects in the PICS bags remained low at both locations. This study demonstrates that the PICS hermetic bags are effective at blocking the effects of external humidity fluctuations as well as the spread of fungi to non-infected kernels.

Commuter Shopping : A study in understanding commuting in the context of shopping

OpenAIRE

Andersson, Åsa; Skoog, Sara; Svensson, Johanna

2014-01-01

Background For ages people have commuted to work, or to other activities, located outside their home municipality. Statements found indicate that the basic decision for commuting are based on utility maximisation and no matter what the character of the benefit is; it should be higher than what can be found closer to the home location. This thesis aims to investigate if people are also commuting with the purpose of obtaining benefits from shopping. The shopping location will in this thesis be ...

Retail Shopping Lists

DEFF Research Database (Denmark)

Schmidt, Marcus

2012-01-01

categories. An association between the frequency of a brand's appearance on lists and the amount of money spent on advertising the brand could not be found. A strong link between brands, prices and store names is revealed. Price in the majority of cases refers to brands rather than to product categories......The paper addresses consumers' shopping lists. The current study is based on a survey of 871 lists collected at retail grocery stores. Most items on shopping lists appear on the product category level rather than the brand level. The importance of the brand level varies considerably across product...

The Effective Design of Bean Bag as a Vibroimpact Damper

Directory of Open Access Journals (Sweden)

A.Q. Liu

2000-01-01

Full Text Available The technique of a bean bag damper has been effectively applied in many engineering fields to control the vibroimpact of a structural system. In this study, the basic parameters responsible for the design of an effective bean bag: the size of beans, the mass ratio of the bean bag to the structure to which it is attached, the clearance distance and the position of the bag, are studied by both theoretical and experimental analyses. These will provide a better understanding of the performance of the bean bag for optimisation of damper design. It was found that reducing the size of beans would increase the exchange of momentum in the system due to the increase in the effective contact areas. Within the range of mass ratios studied, the damping performance of the damper was found to improve with higher mass ratios. There was an optimum clearance for any specific damper whereby the maximum attenuation could be achieved. The position of the bag with respect to nodes and antipodes of the primary structure determined the magnitude of attenuation attainable. Furthermore, the limitations of bean bags have been identified and a general criteria for the design of a bean bag damper has been formulated based on the study undertaken. It was shown that an appropriately configured bean bag damper was capable of reducing the amplitude of vibration by 80% to 90%.

Peepoo bag: self-sanitising single use biodegradable toilet.

Science.gov (United States)

Vinnerås, Björn; Hedenkvist, Mikael; Nordin, Annika; Wilhelmson, Anders

2009-01-01

Unsafe water, sanitation and hygiene together with deficient nutritional status are major contributors to the global burden of disease. Safe collection, disposal and reuse of human excreta would enable the risk of transmission of diseases to be decreased and household food security to be increased in many regions. However, the majority of the 2.5 billion people lacking improved sanitation comprise poor people in societies with weak infrastructure. This study developed a low cost sanitation option requiring little investment and maintenance--a single use, self-sanitising, biodegradable toilet (Peepoo bag) and tested it for smell, degradability and hygiene aspects. It was found that no smell was detectable from a 25 microm thick bag filled with faeces during 24 h in a 10 m2 room at 30 degrees C. Bags that had been in contact with urea-treated faeces or urine for 2 months in air, compost or water at 24 or 37 degrees C showed little signs of degradation. Furthermore, pathogen inactivation modelling of the 4 g of urea present in the bag indicated that appropriate sanitation of faecal material collected is achieved in the bag within 2-4 weeks, after which the bag can be degraded and reused as fertiliser.

Models of quark bags and their consequences

International Nuclear Information System (INIS)

Bogolubov, P.N.

1977-01-01

The development of the first Dubna Quark Bag and the results obtained in this way are considered. The idea of the first Dubna Quark Bag is as follows: baryons are constructed of three quarks measons are constructed of two quarks, and each quark is interpreted as the Dirac particle which moves in a scalar square well. The so-called quasiindependent quark model is considered too. It is a simple quark model based on an analogy with the shell model for nuclei. The quarks are considered as moving in an arbitrary radially-symmetric field, and their one-particle wave function satisfies the usual Dirac equation. Such quark model can give at least the same results as the relativistic bag model. A possibility exists to improve the results of the relativistic quark model with the oscillator interaction between quarks. The results of the MIT-Bag model and the quasiindependent quark model coincide

Growing Shopping Malls and Behavior of Urban Shoppers

OpenAIRE

Rajagopal

2009-01-01

Shopping malls contribute to business more significantly than traditional markets which were viewed as simple convergence of supply and demand. Shopping malls attract buyers and sellers, and induce customers providing enough time to make choices as well as a recreational means of shopping. However, competition between malls, congestion of markets and traditional shopping centers has led mall developers and management to consider alternative methods to build excitement with customers. This stu...

Designing electronic shops, persuading consumers to buy

DEFF Research Database (Denmark)

Dormann, Claire

2000-01-01

The purpose of this article is to show how to design persuasive and successful Web shops. An approach to commercial site design that draws on theories of visual persuasion is proposed. We focus on the role of emotion. Images in an ad are typically meant to create some emotional disposition toward....... To strengthen the discussion, an evaluation of shop home pages, situated within the perspective of visual persuasion is presented. This study has given some indications that viewers form distinctive emotional impressions from shop designs. Thus, by building on visual persuasion theories, we can learn how...... to design seductive Web shops....

78 FR 20695 - Notice of a Public Meeting of the Advisory Committee on Apprenticeship (ACA)

Science.gov (United States)

2013-04-05

... City mall. It is also highly encouraged to use the Metro rail. 3. All purses, bags/briefcases carried... large bags (i.e., knapsacks, camera bags, backpacks and shopping bags, etc). Anyone with the mentioned.... Meeting participants not checked in inside the Pentagon Visitors Center by the scheduled meeting time will...

49 CFR 178.519 - Standards for plastic film bags.

Science.gov (United States)

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Standards for plastic film bags. 178.519 Section... PACKAGINGS Non-bulk Performance-Oriented Packaging Standards § 178.519 Standards for plastic film bags. (a) The identification code for a plastic film bag is 5H4. (b) Construction requirements for plastic film...

49 CFR 178.518 - Standards for woven plastic bags.

Science.gov (United States)

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Standards for woven plastic bags. 178.518 Section... PACKAGINGS Non-bulk Performance-Oriented Packaging Standards § 178.518 Standards for woven plastic bags. (a) The following are identification codes for woven plastic bags: (1) 5H1 for an unlined or non-coated...

Leachables from saline-containing IV bags can alter therapeutic protein properties.

Science.gov (United States)

Chang, Judy Y; Xiao, Nina J; Zhu, Min; Zhang, Jennifer; Hoff, Ed; Russell, Stephen J; Katta, Viswanatham; Shire, Steven J

2010-11-01

To investigate the cause of the observed instability of dulanermin in 100 ml polyolefin (PO) infusion bags containing saline. Diluted dulanermin in IV bags was collected and frozen prior to analysis by size exclusion chromatography. The UV absorption profiles of the IV bag solutions were characterized by using spectrophotometry. Inductively Coupled Plasma Mass Spectrometry (ICP-MS) measured the metal content. Leachables from IV bags were identified by LC-UV-high resolution MS/MS analysis. An elevated loss of dulanermin monomers was observed only in 100 ml PO bags. These IV bag solutions have a compound that contains zinc and has absorbance at 320 nm. This compound was identified to be 2-Mercaptobenzothiazole, and its zinc salt and was found to come from the stopper used in the 100 ml PO bags. The manufacturer has subsequently corrected this problem by using non-latex components in the 100 ml PO IV bag. End-users need to be aware that IV bags made from a particular polymer by the same manufacturer may contain components or use a manufacturing process that results in a different product. Analysis of samples after freezing and thawing proved to be useful in identifying potential incompatibility of dulanermin in the IV bags.

BAG3 affects the nucleocytoplasmic shuttling of HSF1 upon heat stress.

Science.gov (United States)

Jin, Young-Hee; Ahn, Sang-Gun; Kim, Soo-A

2015-08-21

Bcl2-associated athoanogene (BAG) 3 is a member of the co-chaperone BAG family. It is induced by stressful stimuli such as heat shock and heavy metals, and it regulates cellular adaptive responses against stressful conditions. In this study, we identified a novel role for BAG3 in regulating the nuclear shuttling of HSF1 during heat stress. The expression level of BAG3 was induced by heat stress in HeLa cells. Interestingly, BAG3 rapidly translocalized to the nucleus upon heat stress. Immunoprecipitation assay showed that BAG3 interacts with HSF1 under normal and stressed conditions and co-translocalizes to the nucleus upon heat stress. We also demonstrated that BAG3 interacts with HSF1 via its BAG domain. Over-expression of BAG3 down-regulates the level of nuclear HSF1 by exporting it to the cytoplasm during the recovery period. Depletion of BAG3 using siRNA results in reduced nuclear HSF1 and decreased Hsp70 promoter activity. BAG3 in MEF(hsf1(-/-)) cells actively translocalizes to the nucleus upon heat stress suggesting that BAG3 plays a key role in the processing of the nucleocytoplasmic shuttling of HSF1 upon heat stress. Copyright © 2015 Elsevier Inc. All rights reserved.

Monopoles and bags

International Nuclear Information System (INIS)

Jun, J.H.

1980-01-01

From chapter III to chapter V properties of U(1) monopole are discussed by calculating radiative capture of an electron by a monopole, the scattering cross section of an electron by a dyon, and the bound state properties of the electron-dyon system. The Lipkin-Weisberger-Peshkin difficulty is overcome by an introduction of a small magnetic moment of the electron. In chapter VI, the linear deformation of the Prasad-Sommerfield solution of the t'Hooft Polyakov monopole is discussed, where we found all the deformed solutions analytically. In chapter VII and VIII, the question of a deformed bag and properties of an excited bag are discussed. The excited D-state is mixed with S-state to give the correct value of g/sub A/. Initially, in chapter II, energy ratios for trimuons produced through a heavy-lepton cascade decay are calculated

The 3D virtual environment online for real shopping

OpenAIRE

Khalil, Nahla

2015-01-01

The development of information technology and Internet has led to rapidly progressed in e-commerce and online shopping, due to the convenience that they provide consumers. E-commerce and online shopping are still not able to fully replace onsite shopping. In contrast, conventional online shopping websites often cannot provide enough information about a product for the customer to make an informed decision before checkout. 3D virtual shopping environment show great potential for enhancing e-co...

RURAL CUSTOMER SATISFACTION TOWARDS ONLINE SHOPPING IN POLLACHI TALUK

OpenAIRE

K. Jayaprakash; A. Pavithra

2017-01-01

Online shopping is a recent phenomenon in electronic commerce and its definitely going to be the future of shopping in the world. It is user friendly compare to in store shopping because consumers can just complete his requirements just with a click of mouse without leaving their home. In the present work, the researcher intended to analyze the most preferred online shopping website, factors influencing the rural customers towards online shopping and to analyze the level satisfaction of the ...

Fermion bag solutions to some unsolved sign problems

Science.gov (United States)

Li, Anyi; Chandrasekharan, Shailesh

2012-03-01

Some interesting lattice four-fermion models containing N flavors of staggered fermions with Z2 and U(1) chiral symmetries suffer from sign problems in the auxiliary field approach. Earlier calculations have either ignored these sign problems or have circumvented them by adding conjugate fermion fields which changes the model. In this talk we show that the recently proposed fermion bag approach solves these sign problems. The basic idea of the new approach is to collect unpaired fermionic degrees of freedom inside a fermion bag. A resummation of all fermion world lines inside the bag is then sufficient to solve the sign problems. The fermion bag approach provides new opportunities to solve in these ``unsolved'' four-fermion models in the chiral limit efficiently.

48 CFR 252.227-7033 - Rights in shop drawings.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Rights in shop drawings... of Provisions And Clauses 252.227-7033 Rights in shop drawings. As prescribed in 227.7107-(1)(c), use the following clause: Rights in Shop Drawings (APR 1966) (a) Shop drawings for construction means...

48 CFR 1952.227-77 - Rights in shop drawings.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Rights in shop drawings... Rights in shop drawings. As prescribed in 1927.405(h), insert the following clause: Rights in Shop Drawings (FEB 1985) (a) Shop drawings for construction means drawings, submitted to the Government by the...

Off-gas filtration and releases: bag filters

International Nuclear Information System (INIS)

Hennart, D.M.J.G.

1985-01-01

During high-temperature incineration of radioactive waste, some metal oxides are volatilized and carried out with the off-gases. During cooling those oxides react with acidic components generated by the combustion of the fuel oil or of the waste itself. This results in a submicronic crystalline dust in which cesium isotopes are concentrated. Bag filters have been selected at S.C.K./C.E.N. to carry out the first step of dust separation. Two baghouses equipped with Teflon bags with a total filtering area of 100 m 2 have been installed. The bags are cleaned on line by compressed air backflow. The residual dust content is below 3 mg/m 3 , which is sufficiently low to be removed by HEPA filters. The baghouses were put into operation in October 1981 and since then have been on line for about 3000 hours. Some bags had to be replaced after a fire in mid-1983. (orig.)

Development and functional significance of dorsal air bags in ...

African Journals Online (AJOL)

This study describes the morphology and investigates the possible function of the air bags found on the nestlings of Monteiro's Hornbill Tockus monteiri. These air bags increased in size with age and mass of the nestling until 14 d of age, and then decreased in size. By 20 d of age, the air bags were absent. Histological ...

Determinants of Customer Continuance Intention of Online Shopping

Directory of Open Access Journals (Sweden)

Al-maghrabi, T.

2011-01-01

Full Text Available The purpose of this study is to clarify theory and identify factors that could explain the level of continuance intention of e-shopping. A revised technology acceptance model integrates expectation confirmation theory and investigates effects of age differences. An online survey of internet shoppers in Saudi Arabia. Structural equation modelling and invariance analysis confirm model fit. The findings confirm that perceived usefulness, enjoyment and social pressure are determinants of e-shopping continuance. The structural weights are mostly equivalent between young and old but the regression path from perceived usefulness to social pressure is stronger for younger respondents. This research moves beyond e-shopping intentions to factors affecting e-shopping continuance, explaining 55% of intention to continue shopping online. Online strategies cannot ignore direct and indirect effects on continuance intentions. The findings contribute to literature on internet shopping and continuance intentions in the context of Saudi Arabia.

An Exploratory Analysis of Online Shopping Behavior in Turkey

Directory of Open Access Journals (Sweden)

Adnan Veysel Ertemel

2017-06-01

Full Text Available Alongside the technologic developments, transformation in user behavior and business models has been observed. New areas and models are emerged in a lot of grounds like the communication of people or daily activities. So a new face put for shopping behavior by the e-commerce, which is one of the novelties. This study tries to research online shopping behavior in Turkey. With a quantitative research, device usage, the reasons behind to shop or not to shop online, online shopping category and e-commerce site preferences, payment methods, international e-commerce and online marketplace usage is investigated. As implications of the research, “saving time“ is found to be the foremost reason for shopping online in Turkey and “travel and bookings” category is found as the most shopped category among the results of the survey.

2'-Hydroxycinnamaldehyde induces apoptosis through HSF1-mediated BAG3 expression.

Science.gov (United States)

Nguyen, Hai-Anh; Kim, Soo-A

2017-01-01

BAG3, a member of BAG co-chaperone family, is induced by stressful stimuli such as heat shock and heavy metals. Through interaction with various binding partners, BAG3 is thought to play a role in cellular adaptive responses against stressful conditions in normal and neoplastic cells. 2'-Hydroxycinnamaldehyde (HCA) is a natural derivative of cinnamaldehyde and has antitumor activity in various cancer cells. In the present study, for the first time, we identified that HCA induced BAG3 expression and BAG3-mediated apoptosis in cancer cells. The apoptotic cell death induced by HCA was demonstrated by caspase-7, -9 and PARP activation, and confirmed by Annexin V staining in both SW480 and SW620 colon cancer cells. Notably, both the mRNA and protein levels of BAG3 were largely induced by HCA in a dose- and time-dependent manner. By showing transcription factor HSF1 activation, we demonstrated that HCA induces the expression of BAG3 through HSF1 activation. More importantly, knockdown of BAG3 expression using siRNA largely inhibited HCA-induced apoptosis, suggesting that BAG3 is actively involved in HCA-induced cancer cell death. Considering the importance of the stress response mechanism in cancer progression, our results strongly suggest that BAG3 could be a potential target for anticancer therapy.

Specific energy use in Swedish and Norwegian shopping malls

Energy Technology Data Exchange (ETDEWEB)

Stensson, Sofia; Axell, Monica (SP Energy Technology, Boraas (Sweden)); Smaage, Kjell Petter (Evotek AS (Norway)); Fahlen, Per (Chalmers Univ. of Technology, Building Services Engineering, Goeteborg (Sweden))

2009-07-01

The prevalence of shopping malls is growing worldwide. Internationally, there are differences in energy use and system solutions due to local outdoor climate, available energy resources, prices, national building regulations, traditions etc. On the other hand, tenants are usually international chains and they often have the same demands regarding indoor climate, system solutions etc. irrespective of the national differences. Shopping malls overall tends to have large lighting loads, high population density and, hence, a large air conditioning demand. There is also an apparent trend towards increasing glass surfaces and such design feature affects the energy balance of the building. For those interested in the energy efficiency of the building and its installations, it is interesting to know how different system solutions affect the energy use. Benchmarking between buildings gives valuable insight to energy efficient design and operation. However, available information on energy use for such benchmarking in shopping malls is still rather limited. This study investigates shopping malls in Sweden and Norway. Available national statistical data on retail and shopping malls are reviewed. Further building statistical data were collected from building owners and managers, covering energy use in 41 shopping malls. Additional energy use data for 115 shops, within three of these shopping malls were also collected. The building statistical data shows that the average energy use in Norwegian and Swedish shopping malls are approximately 291 and 279 kWh/m2/year respectively. The highest energy use exceeds the lowest figure by approximately 50 percent, indicating a significant potential for improvement. Results also show a wide deviation in energy use of the different shops in a shopping mall. The paper further provides a discussion concerning alternative benchmarking methods and necessary improvements to make valid conclusions regarding energy use in shopping malls.

Turning shopping habits of young consumers into green

NARCIS (Netherlands)

Bialkova, Svetlana; van 't Erve, Sanne; van Hoof, Joris Jasper; Pruyn, Adriaan T.H.; Bigné, Enrique

2014-01-01

Consumers have strong shopping habits, and although being aware of sustainable issues, they hardly do green shopping. Therefore, a challenging question is: how to break the old shopping habits and turn those into green? The current study addresses this question looking at barriers and potential

Why Shops Close Again : An Evolutionary Perspective on the Deregulation of Shopping Hours

OpenAIRE

Kosfeld, M.

1999-01-01

This paper introduces a new perspective on the deregulation of shopping hours based on ideas from evolutionary game theory. We study a retail economy where shopping hours have been deregulated recently. It is argued that first, the deregulation leads to a coordination problem between store owners and customers, and second, the ‘solution’ to this problem depends on the specific cost structure of stores and the preferences of customers. In particular, it may happen that, even if extended shoppi...

Retailing and Shopping on the Internet.

Science.gov (United States)

Rowley, Jennifer

1996-01-01

Internet advertising and commercial activity are increasing. This article examines challenges facing the retail industry on the Internet: location; comparison shopping; security, especially financial transactions; customer base and profile; nature of the shopping experience; and legal and marketplace controls. (PEN)

Impact of e-shopping on shopping-related travel behaviour: Analyses of the Netherlands Mobility Panel data.

NARCIS (Netherlands)

Hoogendoorn-Lanser, S.; Olde Kalter, Marie-José José Theresia; Schaap, Nina

2015-01-01

From the moment e-shopping emerged, there are speculations about the impact that would have on personal mobility. Questions about the impact of e-shopping on mobility increase due to media coverage on the sharp increase in turnover of Internet purchases and the increasing number of consumers that

Measuring consumer perceptions of online shopping convenience

OpenAIRE

Ferreira, Margarida Bernardo

2016-01-01

The aim of this master thesis is to identify which dimensions of convenience affect consumers’ intention of using online shopping. Also it explores a conceptual model to measuring consumer perceptions of online shopping convenience. This paper contains prospects about online consumer behavior, and the results have important implications for retailers, managers and marketers, related to online shopping strategies. An empirical investigation was carried out to test the hypotheses. In order t...

Alternative hospital gift bags and breastfeeding exclusivity.

Science.gov (United States)

Bai, Yeon; Wunderlich, Shahla M; Kashdan, Rickie

2013-01-01

The type of gift bags given to new mothers at the time of discharge from the hospital can influence their confidence in breastfeeding. Most hospitals in the US continue to distribute commercial gift bags containing formula samples despite the reported negative influence of commercial bags on the duration of breastfeeding. This study compared breastfeeding outcomes in women receiving three different kinds of gift bags at discharge. A prospective intervention study was conducted during 2009-2010 in New Jersey. Three breastfeeding cohorts were recruited and assigned to three groups: COMMERCIAL received discharge bags containing formula samples, BF-INFO received breastfeeding information and supplies, and PUMP received breastfeeding information/supplies plus a manual breast pump. Follow-up contacts were at 2, 4, and 12 postpartum weeks to determine breastfeeding outcome. The mean durations of exclusive (EBF) and partial breastfeeding were compared between groups using ANOVA. A total of 386 participants completed the study. The mean EBF duration (weeks) in the PUMP (n = 138, 8.28 ± 4.86) and BF-INFO (n = 121, 7.87 ± 4.63) were significantly longer (P < 0.01) than COMMERCIAL (n = 127, 6.12 ± 4.49). The rate of EBF through 12 weeks in PUMP was most consistent. The mean duration of partial breastfeeding showed similar results: significantly longer in PUMP and BF-INFO than COMMERCIAL (P < 0.01).

CERN SHOP CHRISTMAS SALE

CERN Multimedia

Visits & Exhibition Service

2000-01-01

Looking for Christmas present ideas? Come to the Reception Shop Special Stand in Meyrin, Main Building, ground floor, from Tuesday 12 to Thursday 14 December from 10.00 to 16.00.   Sweat-shirt col zippé, grey, blue, black (M, L, XL) 30.- Sweat-shirt col polo, grey, collar blue (M, L, XL) 30.- T-shirt, black, (M, L, XL) 15.- WWW T-shirt, white, bordeau (M, L, XL) 15.- CERN silk tie (3 colours) 33.- Fancy silk tie (blue, bordeau 25.- Silk scarf (blue, red, yellow) 35.- Swiss army knife with CERN logo 25.- New model of CERN watch 25.- New CERN baseball cap 10.- Antimatter (English/anglais) 30.- The Search for Infinity (French, Italian, English,) 35.- Auf der Suche nach dem Unendlichen 45.- If you miss this special occasion, the articles are also available at the Reception Shop in Building 33 from Monday to Saturday between 08.30 and 17.30 hrs (Shop will be closed at 12.00 on 22.12.).

An architecture for agile shop floor control systems

DEFF Research Database (Denmark)

Langer, Gilad; Alting, Leo

2000-01-01

as shop floor control. This paper presents the Holonic Multi-cell Control System (HoMuCS) architecture that allows for design and development of holonic shop floor control systems. The HoMuCS is a shop floor control system which is sometimes referred to as a manufacturing execution system...

Tourist shopping behavior in a historic downtown area

NARCIS (Netherlands)

Kemperman, A.D.A.M.; Borgers, A.W.J.; Timmermans, H.J.P.

2009-01-01

Shopping is one of the most important activities for tourists. The purpose of this study is to describe and predict tourist shopping route choice behavior in a downtown historic center. Reported routes of tourists in the downtown shopping area of Maastricht, located in the Southern part of the

Flow-shop scheduling problem under uncertainties: Review and trends

Directory of Open Access Journals (Sweden)

Eliana María González-Neira

2017-03-01

Full Text Available Among the different tasks in production logistics, job scheduling is one of the most important at the operational decision-making level to enable organizations to achieve competiveness. Scheduling consists in the allocation of limited resources to activities over time in order to achieve one or more optimization objectives. Flow-shop (FS scheduling problems encompass the sequencing processes in environments in which the activities or operations are performed in a serial flow. This type of configuration includes assembly lines and the chemical, electronic, food, and metallurgical industries, among others. Scheduling has been mostly investigated for the deterministic cases, in which all parameters are known in advance and do not vary over time. Nevertheless, in real-world situations, events are frequently subject to uncertainties that can affect the decision-making process. Thus, it is important to study scheduling and sequencing activities under uncertainties since they can cause infeasibilities and disturbances. The purpose of this paper is to provide a general overview of the FS scheduling problem under uncertainties and its role in production logistics and to draw up opportunities for further research. To this end, 100 papers about FS and flexible flow-shop scheduling problems published from 2001 to October 2016 were analyzed and classified. Trends in the reviewed literature are presented and finally some research opportunities in the field are proposed.

High expression of BAG3 predicts a poor prognosis in human medulloblastoma.

Science.gov (United States)

Yang, Dong; Zhou, Ji; Wang, Hao; Wang, Yutao; Yang, Ge; Zhang, Yundong

2016-10-01

Bcl2-associated athanogene 3 (BAG3), a co-chaperone of the heat shock protein (Hsp) 70, regulates various physiological and pathological processes. However, its role in human medulloblastoma has not been clarified. First of all, the expression of BAG3 was examined in formalin-fixed, paraffin-embedded specimens by immunohistochemical staining. And then, the prognostic role of BAG3 was analyzed in 51 medulloblastoma samples. Finally, the roles of BAG3 in the proliferation, migration, and invasion of Daoy medulloblastoma cell were investigated using a specific short hairpin RNA (shRNA). The expression of BAG3 in medulloblastoma tissues was higher than nontumorous samples. Furthermore, BAG3 overexpression significantly correlated with poor prognosis of patients with medulloblastoma. The overall survival and tumor-free survival in patients with BAG3 low expression were higher than high expression. Univariate and multivariate analysis showed that BAG3 overexpression was an independent prognostic marker for medulloblastoma. After the BAG3 knockdown, the Daoy cells exhibited decreased the ability to proliferate and form neurosphere. The preliminary mechanism study showed that overexpression of BAG3 might facilitate the cell cycle transition from G1 to S phase by modulating the cyclin-dependent kinase 2 (CDK2) and cyclin E expression. Additionally, we found that BAG3 might enhance the medulloblastoma cell migratory and invasive ability. In summary, BAG3 overexpression may regulate the survival and invasive properties of medulloblastoma and may serve as a potential therapy target for medulloblastoma.

Nuclear matter as an MIT bag crystal

International Nuclear Information System (INIS)

Zhang, Q.; Derreth, C.; Schaefer, A.; Greiner, W.

1986-01-01

An MIT bag crystal model of nuclear matter is formulated. The energy bands of the quarks are calculated as a function of the overlap between adjacent bags. A clear indication of substantial overlap is found. Accordingly, infinite nuclear matter is more similar to a quark gas than to a nucleonic structure. (author)

Connection between hydrodynamic, water bag and Vlasov models

International Nuclear Information System (INIS)

Gros, M.; Bertrand, P.; Feix, M.R.

1978-01-01

The connection between hydrodynamic, water bag and Vlasov models is still under consideration with numerical experiments. For long wavelength, slightly non linear excitations and initial preparations such as the usual adiabatic invariant Pn -3 is space independent, the hydrodynamic model is equivalent to the water bag, and for long wavelengths a nice agreement is found with the full numerical solution of the Vlasov equation. For other initial conditions when the water bag cannot be defined, the hydrodynamic approach does not represent the correct behaviour. (author)

PICS bags safely store unshelled and shelled groundnuts in Niger.

Science.gov (United States)

Baributsa, D; Baoua, I B; Bakoye, O N; Amadou, L; Murdock, L L

2017-05-01

We conducted an experiment in Niger to evaluate the performance of hermetic triple layer (Purdue Improved Crop Storage- PICS) bags for the preservation of shelled and unshelled groundnut Arachis hypogaea L. Naturally-infested groundnut was stored in PICS bags and woven bags for 6.7 months. After storage, the average oxygen level in the PICS bags fell from 21% to 18% (v/v) and 21%-15% (v/v) for unshelled and shelled groundnut, respectively. Identified pests present in the stored groundnuts were Tribolium castaneum (Herbst), Corcyra cephalonica (Stainton) and Cryptolestes ferrugineus (Stephens). After 6.7 months of storage, in the woven bag, there was a large increase in the pest population accompanied by a weight loss of 8.2% for unshelled groundnuts and 28.7% for shelled groundnut. In PICS bags for both shelled and unshelled groundnuts, by contrast, the density of insect pests did not increase, there was no weight loss, and the germination rate was the same compared to that recorded at the beginning of the experiment. Storing shelled groundnuts in PICS bags is the most cost-effective way as it increases the quantity of grain stored.

The impact of science shops on university research and education

DEFF Research Database (Denmark)

Hende, Merete; Jørgensen, Michael Søgaard

This report discusses the impact from university-based science shops on curricula and research. Experience from science shops show that besides assisting citizen groups, science shops can also contribute to the development of university curricula and research. This impact has been investigated...... through the SCIPAS questionnaire sent out to science shops and through follow-up interviews with employees from nine different university-based science shops and one university researcher. Not all the cases call themselves science shops, but in the report the term 'science shop' will be used most...... way or the other has had impact on university curricula and/or research. The analysis and the case studies have theoretically been based on literature on universities and education and research as institutions and a few articles about the impact of science shops on education and research. The analysis...

Hybridizing the Skyrmion with an Anti-de-Sitter bag

International Nuclear Information System (INIS)

Rosu, H.

1992-02-01

We discuss a phenomenological model of the nucleon in which a small Anti-de-Sitter bag is placed into the Skyrmion configuration. Such a bag has a timelike boundary and allows naturally the Cheshire Cat Principle. Very important in this model is the membrane of the bag, the 3-dimensional manifold S 1 xS 2 , in which topological techniques will come into play. (author). 63 refs

Environment-Aware Production Schedulingfor Paint Shops in Automobile Manufacturing: A Multi-Objective Optimization Approach.

Science.gov (United States)

Zhang, Rui

2017-12-25

The traditional way of scheduling production processes often focuses on profit-driven goals (such as cycle time or material cost) while tending to overlook the negative impacts of manufacturing activities on the environment in the form of carbon emissions and other undesirable by-products. To bridge the gap, this paper investigates an environment-aware production scheduling problem that arises from a typical paint shop in the automobile manufacturing industry. In the studied problem, an objective function is defined to minimize the emission of chemical pollutants caused by the cleaning of painting devices which must be performed each time before a color change occurs. Meanwhile, minimization of due date violations in the downstream assembly shop is also considered because the two shops are interrelated and connected by a limited-capacity buffer. First, we have developed a mixed-integer programming formulation to describe this bi-objective optimization problem. Then, to solve problems of practical size, we have proposed a novel multi-objective particle swarm optimization (MOPSO) algorithm characterized by problem-specific improvement strategies. A branch-and-bound algorithm is designed for accurately assessing the most promising solutions. Finally, extensive computational experiments have shown that the proposed MOPSO is able to match the solution quality of an exact solver on small instances and outperform two state-of-the-art multi-objective optimizers in literature on large instances with up to 200 cars.

E-COMMERCE FACTORS INFLUENCING CONSUMERS‘ ONLINE SHOPPING DECISION

Directory of Open Access Journals (Sweden)

Živilė Baubonienė

2015-12-01

Full Text Available Purpose – The purpose of this paper is to look at the factors driving online shopping and to develop an understanding of the factors influencing the online shopping by the consumers. This is done by exploring the factors that encourage consumers to shop online through analysis of such advantages as security, fast delivery, comparable price, convenience, cheaper prices and a wider choice. At the same time, the research project reveals the factors that are discouraging for consumers and the benefits received by buyers making purchases online. Specifically, the research explores how online shopping can be affected by such factors as age, gender or occupation. Design/methodology/approach – The factors that affect the consumer online shopping have been disclosed through quantitative research by analysing data collected via a web‐based questionnaire survey. The sample consisted of 183 Lithuanian consumers who were purchasing online. Findings –The empirical findings of this study indicate that the main factors influencing consumers to shop online are convenience, simplicity and better price. Analysis of socio-demographical characteristics such as gender has shown that men shop more often online because of the lower price. Respondents of the 25–35 year age group more often choose shopping online for such reasons as lack of time and a wide range of products. The most beneficial factor of shopping online was identified as a possibility to compare prices and buy at a lower price. Research limitations/implications – This study was done regarding only general conditions and the findings may not necessarily be applicable to a particular e-business. Therefore, in the future it would be highly encouraged to examine consumers’ attitudes towards specialized online shopping websites to look for differences by kind of products or services.Practical implications – Attributes identified by this study could help e-business developers to forme their

Review on the Influences of Bagging Treatment on Pesticide Residue in Fruits

OpenAIRE

ZHAO Xiao-yun; XIE De-fang

2018-01-01

At present, bagging technology has been widely applicated in fruit cultivation. Impact of bagging treatment on the pesticide residues have different results. On the basis of existing achievements, this paper systematically analyzed the influence of different bagging treatments on pesticide residues:such as different ways of applying pesticide, pesticide concentration, number of applying pesticide; bagging materials, bagged layer; the type of pesticide(systemic pesticide, nonendoscopic pestici...

Approximation algorithms for the parallel flow shop problem

NARCIS (Netherlands)

X. Zhang (Xiandong); S.L. van de Velde (Steef)

2012-01-01

textabstractWe consider the NP-hard problem of scheduling n jobs in m two-stage parallel flow shops so as to minimize the makespan. This problem decomposes into two subproblems: assigning the jobs to parallel flow shops; and scheduling the jobs assigned to the same flow shop by use of Johnson's

Bagging Weak Predictors

DEFF Research Database (Denmark)

Lukas, Manuel; Hillebrand, Eric

Relations between economic variables can often not be exploited for forecasting, suggesting that predictors are weak in the sense that estimation uncertainty is larger than bias from ignoring the relation. In this paper, we propose a novel bagging predictor designed for such weak predictor variab...

A hand in the bag; La main dans le sac

Energy Technology Data Exchange (ETDEWEB)

Dube, C.

2009-10-15

Many retailers have abandoned the plastic bag for seemingly more environmentally friendly biodegradable bags. However, the solution may be worse than the problem. Biodegradable plastic bags are essentially made of the same polyethylene that is used in regular plastic bags. The only difference is that oxo-biodegradable bags have an additive such as iron or manganese that enables them to decompose in 12 to 24 months. The plastic decomposes quickly when exposed to ultraviolet rays or stress. Although the bags have been touted to be recyclable, they are not. This article presented an example of how a park bench made of recycled materials began to deteriorate after only a few weeks outside. The additive therefore renders the plastics ineffectual for use in recycled plastic products. The article also emphasized that contrary to popular belief, the role of landfills is not to accelerate decomposition, but limit it in order to prevent emissions of greenhouse gases. 1 fig.

Role of BAG3 in cancer progression: A therapeutic opportunity.

Science.gov (United States)

De Marco, Margot; Basile, Anna; Iorio, Vittoria; Festa, Michelina; Falco, Antonia; Ranieri, Bianca; Pascale, Maria; Sala, Gianluca; Remondelli, Paolo; Capunzo, Mario; Firpo, Matthew A; Pezzilli, Raffaele; Marzullo, Liberato; Cavallo, Pierpaolo; De Laurenzi, Vincenzo; Turco, Maria Caterina; Rosati, Alessandra

2018-06-01

BAG3 is a multifunctional protein that can bind to heat shock proteins (Hsp) 70 through its BAG domain and to other partners through its WW domain, proline-rich (PXXP) repeat and IPV (Ile-Pro-Val) motifs. Its intracellular expression can be induced by stressful stimuli, while is constitutive in skeletal muscle, cardiac myocytes and several tumour types. BAG3 can modulate the levels, localisation or activity of its partner proteins, thereby regulating major cell pathways and functions, including apoptosis, autophagy, mechanotransduction, cytoskeleton organisation, motility. A secreted form of BAG3 has been identified in studies on pancreatic ductal adenocarcinoma (PDAC). Secreted BAG3 can bind to a specific receptor, IFITM2, expressed on macrophages, and induce the release of factors that sustain tumour growth and the metastatic process. BAG3 neutralisation therefore appears to constitute a novel potential strategy in the therapy of PDAC and, possibly, other tumours. Copyright © 2017 Elsevier Ltd. All rights reserved.

Product Characteristics and Internet Shopping Intentions.

Science.gov (United States)

Vijayasarathy, Leo R.

2002-01-01

Discussion of electronic commerce and online marketing focuses on an empirical study that investigated differences between Internet shopping intentions for products categorized by cost and tangibility. Highlights include hypotheses; respondent characteristics; results that showed that intentions to shop using the Internet differ by tangibility of…

Rental Values in UK Shopping Malls

NARCIS (Netherlands)

Yuo, Tony Shun-Te; Lizieri, Colin; McCann, Phillip; Crosby, Neil

This paper employs a unique dataset to analyse the retail rental levels of 1108 retail tenants in 148 UK regional shopping malls. The dataset integrates information regarding the characteristics of the shopping centre, the individual retailer, the brand, the individual unit occupied, the tenancy

Cellular Phone Users- Willingness to Shop Online

OpenAIRE

Norazah Mohd Suki; Norbayah Mohd Suki

2009-01-01

This study aims to identify cellular phone users- shopping motivating factors towards online shopping. 100 university students located in Klang Valley, Malaysia were involved as the respondents. They were required to complete a set of questionnaire and had to own a cellular phone in order to be selected as sample in this study. Three from five proposed hypotheses were supported: purchasing information, shopping utilities and service quality. As a result, marketers and retailers should concent...

CONSUMER BEHAVIOUR AND ATTITUDE TOWARDS ONLINE SHOPPING

OpenAIRE

S. Nethra; Dr. V. T. Dhanaraj

2016-01-01

The popularity of online shopping has caught the attention of many peoples. Many studies have been done in developed nations to know about the attitude and behaviour of consumers towards online shopping. The research is focused on consumer behaviour and attitude towards online shopping in Coimbatore district. The study is based on primary data which has been collected by issuing questionnaire to 200 respondents residing in Coimbatore district by adopting convenient sampling method. The stat...

Passion and dependency in online shopping activities.

Science.gov (United States)

Wang, Chih-Chien; Yang, Hui-Wen

2007-04-01

This study examines the influence of harmonious passion (HP) and obsessive passion (OP) to online shopping dependency. The results show that both HP and OP might lead to online shopping dependency and online shoppers with OP are more dependent on online shopping activities. In addition, this study also found out that HP and OP could be denoted as a sequence of different intensities of passion, where HP might be a necessity of OP.

Overexpressed BAG3 is a potential therapeutic target in chronic lymphocytic leukemia.

Science.gov (United States)

Zhu, Huayuan; Wu, Wei; Fu, Yuan; Shen, Wenyi; Miao, Kourong; Hong, Min; Xu, Wei; Young, Ken H; Liu, Peng; Li, Jianyong

2014-03-01

Bcl-2-associated athanogene 3 (BAG3), a member of BAG family, is shown to sustain cell survival and underlie resistance to chemotherapy in human neoplastic cells. We aimed to determine the exact role and underlying mechanisms of BAG3 in human chronic lymphocytic leukemia (CLL). One hundred human CLL samples and 20 normal B-cell samples from healthy controls were collected. We measured the BAG3 expression in these cells and explored its relationship with known prognostic factors for CLL. The roles of BAG3 in cell apoptosis and migration were evaluated by small interfering RNA-mediated knockdown of BAG3 in primary CLL cells. We showed that BAG3 expression level was increased in CLL cells compared with normal B cells. Moreover, BAG3 expression was particularly upregulated in CD38 positive, unmutated immunoglobulin heavy-chain patients and those with lymphadenopathy and/or splenomegaly. Importantly, patients with increased BAG3 expression level have poor overall survival in subgroups with positive ZAP-70 or those without any "p53 abnormality". In addition, knocking down of BAG3 expression resulted in increased apoptotic ratio and decreased migration in primary CLL cells. Our data indicate that BAG3 is a marker of poor prognostic in specific subgroups of CLL patients and may be a potential therapeutic target for this disease.

Breaking Out of the Local: International dimensions of science shops

Directory of Open Access Journals (Sweden)

Caspar DeBok

2008-09-01

Full Text Available In this article we want to give an overview of the international dimension and the interest of the European Union (EU in the concept of Science Shops. The European Commission (EC manages the day-to-day business by initiating and implementing EU policies and spending EU funds. The EC support for Science Shops has been an important factor for the international interest and progress of the Science Shop movement. This article will not give detailed information about daily routines of a Science Shop. Detailed information about the Science Shop concept can be found at the Living Knowledge website (www.livingknowledge.org. Living Knowledge represents the international Science Shop Network. In this article international developments of the Science Shop Network, like the project TRAMS, and Science Shop backgrounds will be linked with past and new EU policies like the EU 7th Framework Programme for Research. It shows how community-based research does not only have a local dimension. The international Science Shop activities show the strengths of international cooperation to break out of the local and to bring local issues on the international agenda. Detailed information about the Science Shop concept and daily routines of a Science Shop can be found at the Living Knowledge website (www.livingknowledge.org, e.g. at the FAQ section and in the toolbox.

Power Service Shops

Data.gov (United States)

Federal Laboratory Consortium — TVA's Power Service Shops provides expert repair and maintenance of power system components and large industrial equipment. With world-class maintenance facilities...

Can "contamination" occur in body bags?-The example of background fibres in body bags used in Australia.

Science.gov (United States)

Schwendener, Giuliana; Moret, Sébastien; Cavanagh-Steer, Karen; Roux, Claude

2016-09-01

Impurities that are transferred to a crime scene or a body can have a significant negative impact on the investigation if the existence of the contamination is not known, and the source of the contamination is not identified. Forensic consumables, such as DNA swabs, have been known to have caused contaminations, wrongfully linking crimes throughout Europe. In that context, this study focused on body bags, widely used to transfer a corpse from the crime scene to the morgue. Our preliminary survey showed that several countries and Australian Jurisdictions are conducting the sampling of trace evidence at the morgue after the transportation of the body. Potential impurities present in body bags could thus interfere with pertinent traces. The aim of this work was to qualify and quantify the background contamination of trace evidence in body bags used within Australia. Fifteen body bags from four Australian Jurisdictions or laboratories were searched for micro traces. Impurities such as fibres and unidentified particles were detected in each examined body bag, with an estimated average of 3603 coloured fibres and 1429 unidentified particles. This number of fibres is similar to the amount found on a vinyl cinema seat in other studies. Various other contaminants such as pieces of fabric, hairs, parts of insects or feathers were also observed. It is hypothesised that these impurities are introduced during the manufacturing process. This high number of impurities can lead to incorrect conclusions and misleading investigative leads. This paper presents an overview of the problems these impurities can cause and proposes several strategies to prevent future issues. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Transcriptional upregulation of BAG3 upon proteasome inhibition

International Nuclear Information System (INIS)

Wang Huaqin; Liu Haimei; Zhang Haiyan; Guan Yifu; Du Zhenxian

2008-01-01

Proteasome inhibitors exhibit antitumoral activity against malignancies of different histology. Emerging evidence indicates that antiapoptotic factors may also accumulate as a consequence of exposure to these drugs, thus it seems plausible that activation of survival signaling cascades might compromise their antitumoral effects. Bcl-2-associated athanogene (BAG) family proteins are characterized by their property of interaction with a variety of partners involved in modulating the proliferation/death balance, including heat shock proteins (HSP), Bcl-2, Raf-1. In this report, we demonstrated that BAG3 is a novel antiapoptotic molecule induced by proteasome inhibitors in various cancer cells at the transcriptional level. Moreover, we demonstrated that BAG3 knockdown by siRNA sensitized cancer cells to MG132-induced apoptosis. Taken together, our results suggest that BAG3 induction might represents as an unwanted molecular consequence of utilizing proteasome inhibitors to combat tumors

On the vacuum baryon number in the chiral bag model

International Nuclear Information System (INIS)

Jaroszewicz, T.

1984-01-01

We give a rederivation, generalization and interpretation of the result of Goldstone and Jaffe on the vacuum baryon number in the chiral bag model. Our results are based on considering the bag model as a theory of free quarks, massless inside and infinitely massive outside the bag. (orig.)

What do we know about consumer m-shopping behaviour?

OpenAIRE

Marriott, Hannah; Williams, Michael; Dwivedi, Yogesh

2017-01-01

Purpose – This paper provides a review of mobile shopping (m-shopping) acceptance literature to bring international marketing and consumer research attention to m-shopping acceptance factors and limitations in current understandings to propose recommendations for further academic and retailing attention.\\ud Design/methodology – Keyword searches identified consumer-focused literature across mobile commerce, mobile shopping, mobile browsing, and mobile purchasing, published in English language ...

Hedonic Motivations for Online Shopping

OpenAIRE

Pui-Lai To; E-Ping Sung

2014-01-01

The purpose of this study is to investigate hedonic online shopping motivations. A qualitative analysis was conducted to explore the factors influencing online hedonic shopping motivations. The results of the study indicate that traditional hedonic values, consisting of social, role, self-gratification, learning trends, pleasure of bargaining, stimulation, diversion, status, and adventure, and dimensions of flow theory, consisting of control, curiosity, enjoyment, and telepresence, exist in t...

The anti-apoptotic activity of BAG3 is restricted by caspases and the proteasome.

Directory of Open Access Journals (Sweden)

Victoria M Virador

Full Text Available Caspase-mediated cleavage and proteasomal degradation of ubiquitinated proteins are two independent mechanisms for the regulation of protein stability and cellular function. We previously reported BAG3 overexpression protected ubiquitinated clients, such as AKT, from proteasomal degradation and conferred cytoprotection against heat shock. We hypothesized that the BAG3 protein is regulated by proteolysis.Staurosporine (STS was used as a tool to test for caspase involvement in BAG3 degradation. MDA435 and HeLa human cancer cell lines exposed to STS underwent apoptosis with a concomitant time and dose-dependent loss of BAG3, suggesting the survival role of BAG3 was subject to STS regulation. zVAD-fmk or caspase 3 and 9 inhibitors provided a strong but incomplete protection of both cells and BAG3 protein. Two putative caspase cleavage sites were tested: KEVD (BAG3(E345A/D347A within the proline-rich center of BAG3 (PXXP and the C-terminal LEAD site (BAG3(E516A/D518A. PXXP deletion mutant and BAG3(E345A/D347A, or BAG3(E516A/D518A respectively slowed or stalled STS-mediated BAG3 loss. BAG3, ubiquitinated under basal growth conditions, underwent augmented ubiquitination upon STS treatment, while there was no increase in ubiquitination of the BAG3(E516A/D518A caspase-resistant mutant. Caspase and proteasome inhibition resulted in partial and independent protection of BAG3 whereas inhibitors of both blocked BAG3 degradation. STS-induced apoptosis was increased when BAG3 was silenced, and retention of BAG3 was associated with cytoprotection.BAG3 is tightly controlled by selective degradation during STS exposure. Loss of BAG3 under STS injury required sequential caspase cleavage followed by polyubiquitination and proteasomal degradation. The need for dual regulation of BAG3 in apoptosis suggests a key role for BAG3 in cancer cell resistance to apoptosis.

Chiral bag model with constituent quarks: topological and nontopological decisions

International Nuclear Information System (INIS)

Malakhov, I.Yu.; Sveshnikov, K.A.; Fedorov, S.M.; Khalili, M.F.

2002-01-01

The three-phase modification of the hybrid chiral bag containing along with asymptotic freedom and hadronization phases and also intermediate phase of the constituent quarks is considered. The self-consistent solutions of the equations of the model in the (1 + 1)-dimensional case are determined with an account of the fermion vacuum polarization effects. The bag renormalized complete energy is studied as a function of the parameters characterizing the bag geometry and its topological (baryon) charge. It is shown that for nonzero topological charge there exists the whole series of configurations representing the local minima of the bag complete energy and containing all three phases, whereas the bag energy minimum in the nontopological case corresponds to zero dimensions of the area corresponding to asymptotic freedom phase [ru

EMC effect and multiquark bags in nuclei

International Nuclear Information System (INIS)

Kondratyuk, L.; Shmatikov, M.

1984-01-01

Assuming existence of 9q- and 12q bags in niclei the form factors of light nuclei at large momentum transfers and structure functions of deep inelastic scattering of leptons on nuclei are described. It is shown that the existing experimental data can be described in a unified way provided the momentum distribution of quarks in multiquark bags at k 0 has the exponential form PSIsub(q)sup(2)(k) approximately esup(-k/k 0 ) with the parameter k 0 approximately 50-60 MeV. Theoretical results agree well the EMC experimental data on the ratio of the iron and deuteron structure functions with the 20% admixture of 12q-bags in the Fe nucleus

Clinical application of vacuum bag immobilization of the trunk in malignant tumor patients

International Nuclear Information System (INIS)

Su Jianxin; Wu Yuqi; Huang Jun; Lin Chengguang; Liu Hui; Huang Xiaoyan

2005-01-01

Objective: To evaluate the clinical application of vacuum bag immobilization of thorax and pelvis for patients with malignant tumors. Methods: Of 714 patients (fields) chosen randomly, 582(fields) were immobilized with vacuum bag, while the other 132 (fields) used only sand bags, tapes, and other simple immobilizing devices. The field movements were measured and compared before and after the setup, along with 56 patients immobilized twice with vacuum bag. Results: The variance of movement before and after the setup was 6.7% for patients with vacuum bag , while that was 26.5% for patients without the vacuum bag. It was even 32.1% for patients immobilized twice with vacuum bag. Conclusions: The variance of movement decreases significantly with vacuum bag immobilization. It should be used as frequently as possible. As the variance of movement rises obviously when vacuum bag is used twice, the semi-soft vacuum bag should be prepared afresh and checked under the simulator before the second use. (authors)

Study of the suitability of DUO plastic bags for the storage of dynamites.

Science.gov (United States)

Sáiz, Jorge; Ferrando, José-Luis; Atoche, Juan-Carlos; García-Ruiz, Carmen

2013-10-10

A comparative study on the retentiveness of two plastic bags (DUO and Royal Pack) has been carried out by gas chromatography with mass spectrometry detection. Two types of dynamites were packed in both plastic bags. The bags were placed into glass jars and headspace analyses were performed over 11 weeks to detect whether the volatile constituents of the dynamites were released from the bags. DUO plastic bags showed much better retentiveness than Royal Pack plastic bags. Ethylene glycol dinitrate (EGDN) was quickly detected in the headspace of the glass jars containing Royal Pack plastic bags after 1 week of storage. On the contrary, only a weak signal of EGDN, which was not detectable in the total ion chromatogram, was detected after 11 weeks of storage. Moreover, DUO plastic bags have shown less background signals than the Royal Pack bags, being the former bags much more suitable for the storage of dynamites. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

BAG3 promotes chondrosarcoma progression by upregulating the expression of β-catenin

Science.gov (United States)

Shi, Huijuan; Chen, Wenfang; Dong, Yu; Lu, Xiaofang; Zhang, Wenhui; Wang, Liantang

2018-01-01

To investigate the roles of B-cell lymphoma-2 associated athanogene 3 (BAG3) in human chondrosarcoma and the potential mechanisms, the expression levels of BAG3 were detected in the present study, and the associations between BAG3 and clinical pathological parameters, clinical stage as well as the survival of patients were analyzed. The present study detected BAG3 mRNA and protein expression in the normal cartilage cell line HC-a and in SW1353 chondrosarcoma cells by reverse transcription-quantitative polymerase chain reaction and western blot analysis. The BAG3 protein expression in 59 cases of chondrosarcoma, 30 patients with endogenous chondroma and 8 cases of normal cartilage was semi-quantitatively analyzed using the immunohistochemical method. In addition, the BAG3 protein expression level, the clinical pathological parameters, clinical stage and the survival time of patients with chondrosarcoma were analyzed. The plasmid transfection method was employed to upregulate the expression BAG3 and small RNA interference to downregulate the expression of BAG3 in SW1353 cells. The expression levels of BAG3 protein and mRNA were significantly increased in the chondrosarcoma cell line when compared with the normal cartilage cell line. The immunohistochemistry results indicated that BAG3 protein was overexpressed in the tissue of human chondrosarcoma. Statistical analysis showed that the expression level of BAG3 was significantly increased in the different Enneking staging of patients with chondrosarcoma and Tumor staging, and there were no statistical differences in age, gender, histological classification and tumor size. In the in vitro experiments, the data revealed that BAG3 significantly promoted chondrosarcoma cell proliferation, colony-formation, migration and invasion; however, it inhibited chondrosarcoma cell apoptosis. It was observed that BAG3 upregulated β-catenin expression at the mRNA and protein levels. In addition, BAG3 induced the expression of runt

BAG3 promotes chondrosarcoma progression by upregulating the expression of β-catenin.

Science.gov (United States)

Shi, Huijuan; Chen, Wenfang; Dong, Yu; Lu, Xiaofang; Zhang, Wenhui; Wang, Liantang

2018-04-01

To investigate the roles of B‑cell lymphoma‑2 associated athanogene 3 (BAG3) in human chondrosarcoma and the potential mechanisms, the expression levels of BAG3 were detected in the present study, and the associations between BAG3 and clinical pathological parameters, clinical stage as well as the survival of patients were analyzed. The present study detected BAG3 mRNA and protein expression in the normal cartilage cell line HC‑a and in SW1353 chondrosarcoma cells by reverse transcription‑quantitative polymerase chain reaction and western blot analysis. The BAG3 protein expression in 59 cases of chondrosarcoma, 30 patients with endogenous chondroma and 8 cases of normal cartilage was semi-quantitatively analyzed using the immunohistochemical method. In addition, the BAG3 protein expression level, the clinical pathological parameters, clinical stage and the survival time of patients with chondrosarcoma were analyzed. The plasmid transfection method was employed to upregulate the expression BAG3 and small RNA interference to downregulate the expression of BAG3 in SW1353 cells. The expression levels of BAG3 protein and mRNA were significantly increased in the chondrosarcoma cell line when compared with the normal cartilage cell line. The immunohistochemistry results indicated that BAG3 protein was overexpressed in the tissue of human chondrosarcoma. Statistical analysis showed that the expression level of BAG3 was significantly increased in the different Enneking staging of patients with chondrosarcoma and Tumor staging, and there were no statistical differences in age, gender, histological classification and tumor size. In the in vitro experiments, the data revealed that BAG3 significantly promoted chondrosarcoma cell proliferation, colony‑formation, migration and invasion; however, it inhibited chondrosarcoma cell apoptosis. It was observed that BAG3 upregulated β‑catenin expression at the mRNA and protein levels. In addition, BAG3 induced the

A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress.

Science.gov (United States)

Judge, Luke M; Perez-Bermejo, Juan A; Truong, Annie; Ribeiro, Alexandre Js; Yoo, Jennie C; Jensen, Christina L; Mandegar, Mohammad A; Huebsch, Nathaniel; Kaake, Robyn M; So, Po-Lin; Srivastava, Deepak; Pruitt, Beth L; Krogan, Nevan J; Conklin, Bruce R

2017-07-20

Molecular chaperones regulate quality control in the human proteome, pathways that have been implicated in many diseases, including heart failure. Mutations in the BAG3 gene, which encodes a co-chaperone protein, have been associated with heart failure due to both inherited and sporadic dilated cardiomyopathy. Familial BAG3 mutations are autosomal dominant and frequently cause truncation of the coding sequence, suggesting a heterozygous loss-of-function mechanism. However, heterozygous knockout of the murine BAG3 gene did not cause a detectable phenotype. To model BAG3 cardiomyopathy in a human system, we generated an isogenic series of human induced pluripotent stem cells (iPSCs) with loss-of-function mutations in BAG3. Heterozygous BAG3 mutations reduced protein expression, disrupted myofibril structure, and compromised contractile function in iPSC-derived cardiomyocytes (iPS-CMs). BAG3-deficient iPS-CMs were particularly sensitive to further myofibril disruption and contractile dysfunction upon exposure to proteasome inhibitors known to cause cardiotoxicity. We performed affinity tagging of the endogenous BAG3 protein and mass spectrometry proteomics to further define the cardioprotective chaperone complex that BAG3 coordinates in the human heart. Our results establish a model for evaluating protein quality control pathways in human cardiomyocytes and their potential as therapeutic targets and susceptibility factors for cardiac drug toxicity.

Addressing challenges in bar-code scanning of large-volume infusion bags.

Science.gov (United States)

Raman, Kirthana; Heelon, Mark; Kerr, Gary; Higgins, Thomas L

2011-08-01

A hospital pharmacy's efforts to identify and address challenges with bedside scanning of bar codes on large-volume parenteral (LVP) infusion bags are described. Bar-code-assisted medication administration (BCMA) has been shown to reduce medication errors and improve patient safety. After the pilot implementation of a BCMA system and point-of-care scanning procedures at a medical center's intensive care unit, it was noted that nurses' attempted bedside scans of certain LVP bags for product identification purposes often were not successful. An investigation and root-cause analysis, including observation of nurses' scanning technique by a multidisciplinary team, determined that the scanning failures stemmed from the placement of two bar-code imprints-one with the product identification code and another, larger imprint with the expiration date and lot number-adjacently on the LVP bags. The nursing staff was educated on a modified scanning technique, which resulted in significantly improved success rates in the scanning of the most commonly used LVP bags. Representatives of the LVP bag manufacturer met with hospital staff to discuss the problem and corrective measures. As part of a subsequent infusion bag redesign, the manufacturer discontinued the use of the bar-code imprint implicated in the scanning failures. Failures in scanning LVP bags were traced to problematic placement of bar-code imprints on the bags. Interdisciplinary collaboration, consultation with the bag manufacturer, and education of the nursing and pharmacy staff resulted in a reduction in scanning failures and the manufacturer's removal of one of the bar codes from its LVP bags.

The prosurvival protein BAG3: a new participant in vascular homeostasis.

Science.gov (United States)

Carrizzo, Albino; Damato, Antonio; Ambrosio, Mariateresa; Falco, Antonia; Rosati, Alessandra; Capunzo, Mario; Madonna, Michele; Turco, Maria C; Januzzi, James L; De Laurenzi, Vincenzo; Vecchione, Carmine

2016-10-20

Bcl2-associated athanogene 3 (BAG3), is constitutively expressed in a few normal cell types, including myocytes, peripheral nerves and in the brain, and is also expressed in certain tumors. To date, the main studies about the role of BAG3 are focused on its pro-survival effect in tumors through various mechanisms that vary according to cellular type. Recently, elevated concentrations of a soluble form of BAG3 were described in patients affected by advanced stage of heart failure (HF), identifying BAG3 as a potentially useful biomarker in monitoring HF progression. Despite the finding of high levels of BAG3 in the sera of HF patients, there are no data on its possible role on the modulation of vascular tone and blood pressure levels. The aim of this study was to investigate the possible hemodynamic effects of BAG3 performing both in vitro and in vivo experiments. Through vascular reactivity studies, we demonstrate that BAG3 is capable of evoking dose-dependent vasorelaxation. Of note, BAG3 exerts its vasorelaxant effect on resistance vessels, typically involved in the blood pressure regulation. Our data further show that the molecular mechanism through which BAG3 exerts this effect is the activation of the PI3K/Akt signalling pathway leading to nitric oxide release by endothelial cells. Finally, we show that in vivo BAG3 administration is capable of regulating blood pressure and that this is dependent on eNOS regulation since this ability is lost in eNOS KO animals.

An Explanatory Study of Lean Practices in Job Shop Production/ Special Job Production/ Discrete Production/ Batch Shop Production Industries

OpenAIRE

Lavlesh Kumar Sharma; Ravindra Mohan Saxena

2014-01-01

In this paper, the study explores the benefits and advantages of Lean Practices or Lean Thinking in Job shop production/ Special job production/ Discrete production/ Batch shop production industries. The Lean Practices have been applied more compatible in Job shop production than in the continuous/ mass production because of several barriers and hurdles in the industrial context that influence the whole processes again and again, this happens due to the lack of knowledge about...

On the quantisation of one-dimensional bags

International Nuclear Information System (INIS)

Fairley, G.T.; Squires, E.J.

1976-01-01

The quantisation of one-dimensional MIT bags by expanding the fields as a sum of classical modes and truncating the series after the first term is discussed. The lowest states of a bag in a world containing two scalar quark fields are obtained. Problems associated with the zero-point oscillations of the field are discussed. (Auth.)

Radioactive Material Containment Bags

National Research Council Canada - National Science Library

2000-01-01

The audit was requested by Senator Joseph I. Lieberman based on allegations made by a contractor, Defense Apparel Services, about the Navy's actions on three contracts for radioactive material containment bags...

Launching Garbage-Bag Balloons.

Science.gov (United States)

Kim, Hy

1997-01-01

Presents a modification of a procedure for making and launching hot air balloons made out of garbage bags. Student instructions for balloon construction, launching instructions, and scale diagrams are included. (DDR)

Internet Shopping Behavior of College of Education Students

Science.gov (United States)

Kiyici, Mubin

2012-01-01

Internet is an important facilitator for human and humans use this medium almost every phase. As a shopping medium, internet attract human so attract researcher. Younger people can adapt newer technologies so they can adapt internet as shopping tool. In this research it is tried to define college of education students' online shopping behavior and…

Towards an understanding of Internet-based problem shopping behaviour: The concept of online shopping addiction and its proposed predictors

Science.gov (United States)

ROSE, SUSAN; DHANDAYUDHAM, ARUN

2014-01-01

Background: Compulsive and addictive forms of consumption and buying behaviour have been researched in both business and medical literature. Shopping enabled via the Internet now introduces new features to the shopping experience that translate to positive benefits for the shopper. Evidence now suggests that this new shopping experience may lead to problematic online shopping behaviour. This paper provides a theoretical review of the literature relevant to online shopping addiction (OSA). Based on this selective review, a conceptual model of OSA is presented. Method: The selective review of the literature draws on searches within databases relevant to both clinical and consumer behaviour literature including EBSCO, ABI Pro-Quest, Web of Science – Social Citations Index, Medline, PsycINFO and Pubmed. The article reviews current thinking on problematic, and specifically addictive, behaviour in relation to online shopping. Results: The review of the literature enables the extension of existing knowledge into the Internet-context. A conceptual model of OSA is developed with theoretical support provided for the inclusion of 7 predictor variables: low self-esteem, low self-regulation; negative emotional state; enjoyment; female gender; social anonymity and cognitive overload. The construct of OSA is defined and six component criteria of OSA are proposed based on established technological addiction criteria. Conclusions: Current Internet-based shopping experiences may trigger problematic behaviours which can be classified on a spectrum which at the extreme end incorporates OSA. The development of a conceptual model provides a basis for the future measurement and testing of proposed predictor variables and the outcome variable OSA. PMID:25215218

Towards an understanding of Internet-based problem shopping behaviour: The concept of online shopping addiction and its proposed predictors.

Science.gov (United States)

Rose, Susan; Dhandayudham, Arun

2014-06-01

Compulsive and addictive forms of consumption and buying behaviour have been researched in both business and medical literature. Shopping enabled via the Internet now introduces new features to the shopping experience that translate to positive benefits for the shopper. Evidence now suggests that this new shopping experience may lead to problematic online shopping behaviour. This paper provides a theoretical review of the literature relevant to online shopping addiction (OSA). Based on this selective review, a conceptual model of OSA is presented. The selective review of the literature draws on searches within databases relevant to both clinical and consumer behaviour literature including EBSCO, ABI Pro-Quest, Web of Science - Social Citations Index, Medline, PsycINFO and Pubmed. The article reviews current thinking on problematic, and specifically addictive, behaviour in relation to online shopping. The review of the literature enables the extension of existing knowledge into the Internet-context. A conceptual model of OSA is developed with theoretical support provided for the inclusion of 7 predictor variables: low self-esteem, low self-regulation; negative emotional state; enjoyment; female gender; social anonymity and cognitive overload. The construct of OSA is defined and six component criteria of OSA are proposed based on established technological addiction criteria. Current Internet-based shopping experiences may trigger problematic behaviours which can be classified on a spectrum which at the extreme end incorporates OSA. The development of a conceptual model provides a basis for the future measurement and testing of proposed predictor variables and the outcome variable OSA.

Safety grade pressurizer heater power supply connector assembly

International Nuclear Information System (INIS)

Burnett, J.M.; Daftari, R.M.; Reyns, R.M.

1987-01-01

This patent describes a pressurizer heater power supply connector assembly for attaching a power cable to an electric heater within a pressurizer of a pressurized water nuclear reactor system, the electric heater having pin contacts. The assembly comprises: a pin-socket type connector including a tubular body having a first open end carrying a pin-socket contact member and an insert intermediate a shell and the pin-socket contact member, the contact member having socket means for electrically receiving and contacting the pin contacts, and a second open end; a flexible sealed conduit including a flexible corrugated tube having one end connected to the second open end of the pin-socket type connector, and another end; and a shop splice assembly including a header adapter and a hose clamp interconnected between the header adapter and another end of the flexible corrugated tube

INDONESIAN CUSTOMER SATISFACTION IN ONLINE SHOPPING TRADING

OpenAIRE

Hermawan F.; Wijayanti S.H.

2018-01-01

This research aims to find out if the ease of shopping, site design, informative, comprehensive, and communication have a significant influence on the level of Indonesian customer satisfaction in online shopping transactions and how the impact to the word of mouth communication. Respondents of this study are the 250 students of Jakarta colleges. This study found that the variables of design, simplicity, and security have an influence on customer satisfaction in shopping online, while the info...

Modeling the Joint Choice Decisions on Urban Shopping Destination and Travel-to-Shop Mode: A Comparative Study of Different Structures

Directory of Open Access Journals (Sweden)

Chuan Ding

2014-01-01

Full Text Available The joint choice of shopping destination and travel-to-shop mode in downtown area is described by making use of the cross-nested logit (CNL model structure that allows for potential interalternative correlation along the both choice dimensions. Meanwhile, the traditional multinomial logit (MNL model and nested logit (NL model are also formulated, respectively. This study uses the data collected in the downtown areas of Maryland-Washington, D.C. region, for shopping trips, considering household, individual, land use, and travel related characteristics. The results of the model reveal the significant influencing factors on joint choice travel behavior between shopping destination and travel mode. A comparison of the different models shows that the proposed CNL model structure offers significant improvements in capturing unobserved correlations between alternatives over MNL model and NL model. Moreover, a Monte Carlo simulation for a group of scenarios assuming that there is an increase in parking fees in downtown area is undertaken to examine the impact of a change in car travel cost on the joint choice of shopping destination and travel mode switching. The results are expected to give a better understanding on the shopping travel behavior.

Radiative decays of vector mesons in the chiral bag model

International Nuclear Information System (INIS)

Tabachenko, A.N.

1988-01-01

A new model of radiative π-meson decays of vector mesons in the chiral bag model is proposed. The quark-π-meson interaction has the form of a pseudoscalar coupling and is located on the bag surface. The vector meson decay width depends on the quark masses, the π-meson decay constant, the radius of the bag, and the free parameter Z 2 , which specifies the disappearance of the bag during the decay. The obtained results for the omega- and p-decay widths are in satisfactory agreement with the experiment

BAG3 regulates contractility and Ca(2+) homeostasis in adult mouse ventricular myocytes.

Science.gov (United States)

Feldman, Arthur M; Gordon, Jennifer; Wang, JuFang; Song, Jianliang; Zhang, Xue-Qian; Myers, Valerie D; Tilley, Douglas G; Gao, Erhe; Hoffman, Nicholas E; Tomar, Dhanendra; Madesh, Muniswamy; Rabinowitz, Joseph; Koch, Walter J; Su, Feifei; Khalili, Kamel; Cheung, Joseph Y

2016-03-01

Bcl2-associated athanogene 3 (BAG3) is a 575 amino acid anti-apoptotic protein that is constitutively expressed in the heart. BAG3 mutations, including mutations leading to loss of protein, are associated with familial cardiomyopathy. Furthermore, BAG3 levels have been found to be reduced in end-stage non-familial failing myocardium. In contrast to neonatal myocytes in which BAG3 is found in the cytoplasm and involved in protein quality control and apoptosis, in adult mouse left ventricular (LV) myocytes BAG3 co-localized with Na(+)-K(+)-ATPase and L-type Ca(2+) channels in the sarcolemma and t-tubules. BAG3 co-immunoprecipitated with β1-adrenergic receptor, L-type Ca(2+) channels and phospholemman. To simulate decreased BAG3 protein levels observed in human heart failure, we targeted BAG3 by shRNA (shBAG3) in adult LV myocytes. Reducing BAG3 by 55% resulted in reduced contraction and [Ca(2+)]i transient amplitudes in LV myocytes stimulated with isoproterenol. L-type Ca(2+) current (ICa) and sarcoplasmic reticulum (SR) Ca(2+) content but not Na(+)/Ca(2+) exchange current (INaCa) or SR Ca(2+) uptake were reduced in isoproterenol-treated shBAG3 myocytes. Forskolin or dibutyryl cAMP restored ICa amplitude in shBAG3 myocytes to that observed in WT myocytes, consistent with BAG3 having effects upstream and at the level of the receptor. Resting membrane potential and action potential amplitude were unaffected but APD50 and APD90 were prolonged in shBAG3 myocytes. Protein levels of Ca(2+) entry molecules and other important excitation-contraction proteins were unchanged in myocytes with lower BAG3. Our findings that BAG3 is localized at the sarcolemma and t-tubules while modulating myocyte contraction and action potential duration through specific interaction with the β1-adrenergic receptor and L-type Ca(2+) channel provide novel insight into the role of BAG3 in cardiomyopathies and increased arrhythmia risks in heart failure. Copyright © 2016 Elsevier Ltd. All rights

BAG3 regulates contractility and Ca2+ homeostasis in adult mouse ventricular myocytes

Science.gov (United States)

Feldman, Arthur M.; Gordon, Jennifer; Wang, JuFang; Song, Jianliang; Zhang, Xue-Qian; Myers, Valerie D.; Tilley, Douglas G.; Gao, Erhe; Hoffman, Nicholas E.; Tomar, Dhanendra; Madesh, Muniswamy; Rabinowitz, Joseph; Koch, Walter J.; Su, Feifei; Khalili, Kamel; Cheung, Joseph Y.

2016-01-01

Bcl2-associated athanogene 3 (BAG3) is a 575 amino acid anti-apoptotic protein that is constitutively expressed in the heart. BAG3 mutations, including mutations leading to loss of protein, are associated with familial cardiomyopathy. Furthermore, BAG3 levels have been found to be reduced in end-stage non-familial failing myocardium. In contrast to neonatal myocytes in which BAG3 is found in the cytoplasm and involved in protein quality control and apoptosis, in adult mouse left ventricular (LV) myocytes BAG3 co-localized with Na+-K+-ATPase and L-type Ca2+ channels in the sarcolemma and t-tubules. BAG3 co-immunoprecipitated with β1-adrenergic receptor, L-type Ca2+ channels and phospholemman. To simulate decreased BAG3 protein levels observed in human heart failure, we targeted BAG3 by shRNA (shBAG3) in adult LV myocytes. Reducing BAG3 by 55% resulted in reduced contraction and [Ca2+]i transient amplitudes in LV myocytes stimulated with isoproterenol. L-type Ca2+ current (ICa) and sarcoplasmic reticulum (SR) Ca2+ content but not Na+/Ca2+ exchange current (INaCa) or SR Ca2+ uptake were reduced in isoproterenol-treated shBAG3 myocytes. Forskolin or dibutyrl cAMP restored ICa amplitude in shBAG3 myocytes to that observed in WT myocytes, consistent with BAG3 having effects upstream and at the level of the receptor. Resting membrane potential and action potential amplitude were unaffected but APD50 and APD90 were prolonged in shBAG3 myocytes. Protein levels of Ca2+ entry molecules and other important excitation-contraction proteins were unchanged in myocytes with lower BAG3. Our findings that BAG3 is localized at the sarcolemma and t-tubules while modulating myocyte contraction and action potential duration through specific interaction with the β1-adrenergic receptor and L-type Ca2+ channel provide novel insight into the role of BAG3 in cardiomyopathies and increased arrhythmia risks in heart failure. PMID:26796036

BAG3 regulates epithelial-mesenchymal transition and angiogenesis in human hepatocellular carcinoma.

Science.gov (United States)

Xiao, Heng; Cheng, Shaobing; Tong, Rongliang; Lv, Zheng; Ding, Chaofeng; Du, Chengli; Xie, Haiyang; Zhou, Lin; Wu, Jian; Zheng, Shusen

2014-03-01

Bcl2-associated athanogene 3 (BAG3) protein is a co-chaperone of heat-shock protein (Hsp) 70 and may regulate major physiological and pathophysiological processes. However, few reports have examined the role of BAG3 in human hepatocellular carcinoma (HCC). In this study, we show that BAG3 regulates epithelial-mesenchymal transition (EMT) and angiogenesis in HCC. BAG3 was overexpressed in HCC tissues and cell lines. BAG3 knockdown resulted in reduction in migration and invasion of HCC cells, which was linked to reversion of EMT by increasing E-cadherin expression and decreasing N-cadherin, vimentin and slug expression, as well as suppressing matrix metalloproteinase 2 (MMP-2) expression. In a xenograft tumorigenicity model, BAG3 knockdown effectively inhibited tumor growth and metastasis through reduction in CD34 and VEGF expression and reversal of the EMT pathway. In conclusion, BAG3 is associated with the invasiveness and angiogenesis in HCC, and the BAG3 gene may be a novel therapeutic approach against HCC.

Legitimization of regulatory norms: Waterfowl hunter acceptance of changing duck bag limits

Science.gov (United States)

Schroeder, Susan A.; Fulton, David C.; Lawrence, Jeffrey S.; Cordts, Steven D.

2014-01-01

Few studies have examined response to regulatory change over time, or addressed hunter attitudes about changes in hunting bag limits. This article explores Minnesota waterfowl hunters’ attitudes about duck bag limits, examining attitudes about two state duck bag limits that were initially more restrictive than the maximum set by the U.S. Fish and Wildlife Service (USFWS), but then increased to match federal limits. Results are from four mail surveys that examined attitudes about bag limits over time. Following two bag limit increases, a greater proportion of hunters rated the new bag limit “too high” and a smaller proportion rated it “too low.” Several years following the first bag limit increase, the proportion of hunters who indicated that the limit was “too high” had declined, suggesting hunter acceptance of the new regulation. Results suggest that waterfowl bag limits may represent legal norms that influence hunter attitudes and gain legitimacy over time.

Urban artisanal gold shops and mercury emissions

International Nuclear Information System (INIS)

Cordy, P.; Veiga, M.; Carrasco, V.H.G.

2008-01-01

Artisanal miners in developing countries use mercury amalgamation processes to extract gold. The amalgams are then refined before being sold on to urban gold shops. The amalgams can often contain between 2 to 40 per cent mercury. Unburned amalgams are also often sold directly to gold shops. There are serious health risks for shop employees and nearby populations when the gold is melted and further purified. Studies have shown that mercury concentrations in the ambient air of gold shops often exceeds World Health Organization (WHO) limits by an order of magnitude or more. This study examined the practices and technologies used to refine gold in Latin America and Indonesia. The study compared and contrasted various refining methods and their resulting mercury emissions. Methods of reducing mercury emissions were also investigated, including a filtration system designed to capture 80 per cent of mercury emissions. Barriers to implementing mercury emissions reduction plans were also investigated. It was concluded that the design of urban gold shops must include condensers, fume hoods, and efficient mercury capture systems. 15 refs

BAG3 Protein Is Over-Expressed in Endometrioid Endometrial Adenocarcinomas.

Science.gov (United States)

Esposito, Veronica; Baldi, Carlo; Zeppa, Pio; Festa, Michelina; Guerriero, Luana; d'Avenia, Morena; Chetta, Massimiliano; Zullo, Fulvio; De Laurenzi, Vincenzo; Turco, Maria Caterina; Rosati, Alessandra; Guida, Maurizio

2017-02-01

Endometrioid endometrial cancer is the most common gynaecological tumor in developed countries, and its incidence is increasing. The definition of subtypes, based on clinical and endocrine features or on histopathological characteristics, correlate to some extent with patient's prognosis, but there is substantial heterogeneity within tumor types. The search for molecules and mechanisms implied in determining the progression and the response to therapy for this cancer is still ongoing. BAG3 protein, a member of BAG family of co-chaperones, has a pro-survival role in several tumor types. BAG3 anti-apoptotic properties rely on its characteristic to bind several intracellular partners, thereby, modulating crucial events such as apoptosis, differentiation, cell motility, and autophagy. BAG3 expression in human endometrial cancer tissues was not investigated so far. Here, we show that BAG3 protein levels are elevated in tumoral and hyperplastic cells in respect to normal glands. Furthermore, BAG3 subcellular localization appears to be changed in tumoral compared to normal cells. Our results indicate a possible role for BAG3 protein in the maintenance of cell survival in endometrioid endometrial cancer and suggest that this field of studies is worthy of further investigations. J. Cell. Physiol. 232: 309-311, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Let's Do It Again: Bagging Equity Premium Predictors

DEFF Research Database (Denmark)

Hillebrand, Eric Tobias; Lee, Tae-Hwy; Medeiros, Marcelo C.

The literature on excess return prediction has considered a wide array of estimation schemes, among them unrestricted and restricted regression coefficients. We consider bootstrap aggregation (bagging) to smooth parameter restrictions. Two types of restrictions are considered: positivity...... by smoothing the restriction through bagging....

Performance of PICS bags under extreme conditions in the sahel zone of Niger.

Science.gov (United States)

Baoua, Ibrahim B; Bakoye, Ousmane; Amadou, Laouali; Murdock, Larry L; Baributsa, Dieudonne

2018-03-01

Experiments in Niger assessed whether extreme environmental conditions including sunlight exposure affect the performance of triple-layer PICS bags in protecting cowpea grain against bruchids. Sets of PICS bags and woven polypropylene bags as controls containing 50 kg of naturally infested cowpea grain were held in the laboratory or outside with sun exposure for four and one-half months. PICS bags held either inside or outside exhibited no significant increase in insect damage and no loss in weight after 4.5 months of storage compared to the initial values. By contrast, woven bags stored inside or outside side by side with PICS bags showed several-fold increases in insects present in or on the grain and significant losses in grain weight. Grain stored inside in PICS bags showed no reduction in germination versus the initial value but there was a small but significant drop in germination of grain in PICS bags held outside (7.6%). Germination rates dropped substantially more in grain stored in woven bags inside (16.1%) and still more in woven bags stored outside (60%). PICS bags held inside and outside retained their ability to maintain internal reduced levels of oxygen and elevated levels of carbon dioxide. Exposure to extreme environmental conditions degraded the external polypropylene outer layer of the PICS triple-layer bag. Even so, the internal layers of polyethylene were more slowly degraded. The effects of exposure to sunlight, temperature and humidity variation within the sealed bags are described.

Soliton Bag Model

International Nuclear Information System (INIS)

Wilets, L.; Bickeboeller, M.; Birse, M.C.

1985-01-01

A summary of recent and current research on the Soliton Bag Model is presented. The unique feature of the model, namely dynamics, is emphasized, since this permits calculation of reactions within the framework of a covariant effective Lagrangian. One gluon exchange effects are included. 17 refs., 3 figs

Nurses' shop stewards and their collaboration with management

DEFF Research Database (Denmark)

Bild, Tage; Hjalager, Anne-Mette; Lassen, Morten Staun

2009-01-01

Purpose - This study investigates the collaboration between Danish nurses' shop stewards and workplace management. The aim of the study is to track changes in workplace climate after a major structural reform of the health sector. Design/methodology/approach - The data source for the study...... is a comprehensive survey among union representatives in the health and care sectors. Findings - Generally, and not surprisingly, shops stewards maintain closer relations and a higher degree of loyalty to the nearest managers rather than management at higher levels in the hierarchy. It can also be demonstrated...... that more experienced shop stewards, those who have been employed in this position and in the workplace for the longest terms have more affirmative relations to management than less experienced shop stewards with shorter tenure. Those shop stewards who spend much time on the entitled duties are rewarded...

Hsp70-Bag3 interactions regulate cancer-related signaling networks.

Science.gov (United States)

Colvin, Teresa A; Gabai, Vladimir L; Gong, Jianlin; Calderwood, Stuart K; Li, Hu; Gummuluru, Suryaram; Matchuk, Olga N; Smirnova, Svetlana G; Orlova, Nina V; Zamulaeva, Irina A; Garcia-Marcos, Mikel; Li, Xiaokai; Young, Z T; Rauch, Jennifer N; Gestwicki, Jason E; Takayama, Shinichi; Sherman, Michael Y

2014-09-01

Bag3, a nucleotide exchange factor of the heat shock protein Hsp70, has been implicated in cell signaling. Here, we report that Bag3 interacts with the SH3 domain of Src, thereby mediating the effects of Hsp70 on Src signaling. Using several complementary approaches, we established that the Hsp70-Bag3 module is a broad-acting regulator of cancer cell signaling by modulating the activity of the transcription factors NF-κB, FoxM1, Hif1α, the translation regulator HuR, and the cell-cycle regulators p21 and survivin. We also identified a small-molecule inhibitor, YM-1, that disrupts the Hsp70-Bag3 interaction. YM-1 mirrored the effects of Hsp70 depletion on these signaling pathways, and in vivo administration of this drug was sufficient to suppress tumor growth in mice. Overall, our results defined Bag3 as a critical factor in Hsp70-modulated signaling and offered a preclinical proof-of-concept that the Hsp70-Bag3 complex may offer an appealing anticancer target. ©2014 American Association for Cancer Research.

Relationships among Shopping Quality and Corporate Social Responsibility of Shopping Centers and Consumer Satisfaction: Case from Novi Sad (Serbia

Directory of Open Access Journals (Sweden)

Ivana Blešić

2014-02-01

Full Text Available Taking into consideration satisfied customer as necessary for business maintenance, companies are trying to discover determinants which have the biggest influence on their consumer satisfaction. Here are presented two factors that have influence on consumer satisfaction in shopping centers: quality of shopping and corporate social responsibility. In this research, each of these factors had six elements. The results of the regression analysis are that “Value for money in stores” (beta=0.387, p=0.000 has the greatest impact on satisfaction when shopping quality performance is concerned, and that “Retailer support for (national/local cultural and sport events“ (beta=0.333, p<0.001 has the greatest impact on satisfaction in the case of CSR performance. Further analysis showed the difference in consumer perception of corporate social responsibility, depending on their occupation and level of education. It is also important to mention that consumers with environment and empathic concern have higher scores perception of CSR. However, there is not statistically important difference in consumer perception of shopping quality in shopping centers

The effects of four agrobotanical extracts and three types of bags on ...

African Journals Online (AJOL)

... Shaki area of Oyo State, Nigeria and treated with extracts from Azadiractha indica (neem) leaf, Xylopia aethiopica(uda) pod, Occimum graticimum (nche anwu) leaf and Zingiber officinale (ginger) stem tuber. The storage bags were 0.05mm gauge polythene bags, 0.05mm gauge polythene-lined-jute bags and jute bags.

Vented spikes improve delivery from intravenous bags with no air headspace.

Science.gov (United States)

Galush, William J; Horst, Travis A

2015-07-01

Flexible plastic bags are the container of choice for most intravenous (i.v.) infusions. Under certain circumstances, however, the air-liquid interface present in these i.v. bags can lead to physical instability of protein biopharmaceuticals, resulting in product aggregation. In principle, the air headspace present in the bags can be removed to increase drug stability, but experiments described here show that this can result in incomplete draining of solution from the bag using gravity delivery, or generation of negative pressure in the bag when an infusion pump is used. It is expected that these issues could lead to incomplete delivery of medication to patients or pump-related problems, respectively. However, here it is shown that contrary to the standard pharmacy practice of using nonvented spikes with i.v. bags, the use of vented spikes with i.v. bags that lack air headspace allows complete delivery of the dose solution without impacting the physical stability of a protein-based drug. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association.

Non-leptonic hyperon decays and the chiral meson coupling to bags

International Nuclear Information System (INIS)

Horvat, D.; Tadic, D.

1986-01-01

Hyperon nonleptonic decays have been analyzed using a chiral-bag model instead of the MIT-bag model which was used in earlier analyses. The adopted theoretical formalism allows a step by step comparison between the new and the old approaches. The results are in agreement with the calculation which has used chiral model in its cloudy-bag variant. Chiral-bag model based theoretical predictions are not significantly different from the old MIT-bag model based results. Theory can account for overall gross features of the hyperon nonleptonic decays but not for the fine details like the exact, almost vanishing, value of the A(Σsub(+) + ) amplitude. (orig.)

Effects of time of day on shopping behavior.

Science.gov (United States)

Chebat, J C

1999-04-01

Shoppers interviewed in a shopping mall at different times of the day show different activities within the mall and attitudes toward the products. Prices also vary with the time of the day. These results can be explained in terms of shopping values and the related demographic characteristics of the population visiting the shopping center at different times of the day.

PLASTIC BAGS: AQUESTION OF CHANGING HABITS

OpenAIRE

Lorenzett, Juliana Benitti; Rizzatti, Cláudia Bach; Lorenzett, Daniel Benitti; Godoy, Leoni Pentiado

2013-01-01

http://dx.doi.org/10.5902/223613087725This study aimed to conduct a review about of the use and disposal of plastic bags, checking in the existing literature that has been studied and the current status of this environmental problem, besides conducting a survey with customers in a supermarket to check the involvement of the community with the adoption of reusable bags. A bibliographic search was conducted by internet, and is considered therefore works available online. The study survey was gi...

Consumer Buying Behavior Towards Online Shopping Stores in Malaysia

OpenAIRE

Mehrdad Salehi

2011-01-01

The Internet as a global medium is quickly gaining interest and attractiveness as the most revolutionary marketing tool. The global nature of communication and shopping has as well redefined, seeing that it is the perfect vehicle for online shopping stores. Online convenient shop is mostly reflected in shorter time and less energy spent, including shipping cost reduction, less crowd and queues than real markets, unlimited time and space, which all increase convenience of shopping. Internet sh...

End-user Acceptance of Online Shopping Sites in India

OpenAIRE

Bolar K; Shaw B

2015-01-01

Online shopping sites have recently gained momentum in India. Since the ecommerce industry is in infancy state, customer (end user) satisfaction with the online shopping is the prime concern because decreasing customer satisfaction leads to negative electronic word of mouth (eWOM) which is very severe for the business. Through a dataset gathered from 127 online shopping customers in with respect to online shopping sites in India, this study investigates the role of website quality, informatio...

Multiattribute shopping models and ridge regression analysis

NARCIS (Netherlands)

Timmermans, H.J.P.

1981-01-01

Policy decisions regarding retailing facilities essentially involve multiple attributes of shopping centres. If mathematical shopping models are to contribute to these decision processes, their structure should reflect the multiattribute character of retailing planning. Examination of existing

Use of pliable bags in liquid scintillation counting

International Nuclear Information System (INIS)

Simonnet, G.; Jacquet, M.A.; Sharif, A.; Engler, R.

1981-01-01

Pliable plastic bags have been used to replace glass or plastic vials for liquid scintillation counting. The two major advantages of this method are the lower cost of the plastic bags and the fact that, per sample, the radioactive waste is significantly reduced. The following parameters have been checked: the impermeability of the bags to various scintillator mixtures and the fact that neither the irregular shape of the bags nor their position in the counting chamber had any effect on the results of the counting. The latter was also constant with time, at least over a period of 10 days. The technique has been used to count the radioactivity of 3 H-DNA precipitates prepared from bacteria and lymphocytes and deposited on filters impregnated with only 200 μl scintillator. It is a method that can be applied to the counting of any samples deposited on filters and insoluble in scintillator. (author)

MATERIALISTIC VALUES, SHOPPING, AND LIFE SATISFACTION IN ROMANIA

Directory of Open Access Journals (Sweden)

VALERIU FRUNZARU

2015-11-01

Full Text Available Numerous studies have shown that generally materialists are less happy than those lower in materialism. Several studies confirm that people who experience a lower level of life satisfaction are more interested in shopping; therefore materialism determines directly and indirectly (mediated by life satisfaction the desire of going shopping. There are only few studies that deal with this topic within Romanian consumers. The conceptual model proposed here was tested on a convenience sample of 390 Romanians. Using structural equation modelling, our findings confirm the hypothetical model only partially. Materialism leads to life dissatisfaction and shopping, but life dissatisfaction does not increase shopping. To the contrary, there is a positive relationship between life satisfaction and the desire for shopping. One possible explanation is that Romanians perceive materialism as a positive attitude. Anyway, nuances should be considered regarding the role of money and possession in bringing life satisfaction

Cost analysis of premixed multichamber bags versus compounded parenteral nutrition: breakeven point.

Science.gov (United States)

Bozat, Erkut; Korubuk, Gamze; Onar, Pelin; Abbasoglu, Osman

2014-02-01

Industrially premixed multichamber bags or hospital-manufactured compounded products can be used for parenteral nutrition. The aim of this study was to compare the cost of these 2 approaches. Costs of compounded parenteral nutrition bags in an university hospital were calculated. A total of 600 bags that were administered during 34 days between December 10, 2009 and February 17, 2010 were included in the analysis. For quality control, specific gravity evaluation of the filled bags was performed. It was calculated that the variable cost of a hospital compounded bag was $26.15. If we take the annual fixed costs into consideration, the production cost reaches $36.09 for each unit. It was estimated that the cost for the corresponding multichamber bag was $37.79. Taking the fixed and the variable costs into account, the breakeven point of the hospital compounded and the premixed multichamber bags was seen at 5,404 units per year. In specific gravity evaluation, it was observed that the mean and interval values were inside the upper and lower control margins. In this analysis, usage of hospital-compounded parenteral nutrition bags showed a cost advantage in hospitals that treat more than 15 patients per day. In small volume hospitals, premixed multichamber bags may be more beneficial.

[Expression of BAG3 Gene in Acute Myeloid Leukemia and Its Prognostic Value].

Science.gov (United States)

Zhu, Hua-Yuan; Fu, Yuan; Wu, Wei; Xu, Jia-Dai; Chen, Ting-Mei; Qiao, Chun; Li, Jian-Yong; Liu, Peng

2015-08-01

To investigate the expression of BAG3 gene in acue myeloid leukemia (AML) and its prognostic value. Real-time quantitative RT-PCR was used to detect the expression of BAG3 mRNA in 88 previously untreated AML patients. The corelation of BAG3 expression level with clinical characteristics and known prognostic markers of AML was analyzed. In 88 patients with AML, the expression of BAG3 mRNA in NPMI mutated AML patients was obviously lower than that in NPMI unmutated patients (P = 0.018). The expression level of BAG3 mRNA did not related to clinical parameters, such as age, sex, FAB subtype, WBC count, extra-modullary presentation, and to prognostic factors including cytogenetics, FLT3-ITD, c-kit and CEBPα mutation status (P > 0.05). The expression level of BAG3 had no obvious effect on complete remission (CR) of patients in first treatment. The expression level of BAG3 in non-M3 patients was higher than that in relapsed patients (P = 0.036). The expression level of BAG3 had no effect on overall survival (OS) of patients. The expression level of BAG3 does not correlated with known-prognostic markers of AML, only the expression level of BAG3 in NPM1 mutated patients is lower than that in NPM1 unmutated patients. The expression level of BAG3 has no effect on OS of AML patients, the BAG3 can not be difined as a prognostic marker in AML.

Warming preterm infants in the delivery room: polyethylene bags, exothermic mattresses or both?

Science.gov (United States)

McCarthy, Lisa K; O'Donnell, Colm P F

2011-12-01

To compare the admission temperature of infants treated with polyethylene bags alone to infants treated with exothermic mattresses in addition to bags in the delivery room. We prospectively studied infants born at bags at birth. Some infants were also placed on mattresses. Admission axillary temperatures were measured in all infants on admission to the neonatal intensive care. We compared the temperatures of infants treated with bags alone to those treated with mattresses and bags. We studied 43 infants: 15 were treated with bags while 28 were treated with a bag and mattress. Mean admission temperature was similar between the groups. Hypothermia and hyperthermia occurred more frequently in infants treated with a bag and mattress, and more infants treated with a bag had admission temperatures 36.5-37.5°C. The use of exothermic mattresses in addition to polyethylene bags, particularly in younger, smaller newborns, may result in more hypothermia and hyperthermia on admission. A randomised controlled trial is necessary to determine which strategy results in more infants having admission temperatures in the normal range. © 2011 The Author(s)/Acta Paediatrica © 2011 Foundation Acta Paediatrica.

Silencing of BAG3 inhibits the epithelial-mesenchymal transition in human cervical cancer.

Science.gov (United States)

Song, Fei; Wang, Geng; Ma, Zhifang; Ma, Yuebing; Wang, Yingying

2017-11-10

Bcl2-associated athanogene 3 (BAG3) has been reported to be involved in aggressive progression of many tumors. In the present study, we examined the expression of BAG3 in human cervical cancer (CC) tissues and investigated the role of BAG3 in SiHa and HeLa cell growth, migration, and invasion. Here, we found that most of CC tissues highly expressed the protein and mRNA of BAG3, while their expression was obviously lower in paired normal tissues (all pBAG3 expression was associated with FIGO stage and metastasis (all pBAG3 siRNAs inhibited SiHa and HeLa cell growth, invasion and migration. Mechanically, BAG3 siRNAs inhibited the expression of EMT-regulating markers, involving MMP2, Slug and N-cadherin, and increased the expression of E-cadherin. In a xenograft nude model, BAG3 siRNAs inhibited tumor growth and the expression of EMT biomarkers. In conclusion, BAG3 is involved in the EMT process, including cell growth, invasion and migration in the development of CC. Thus, BAG3 target might be recommended as a novel therapeutic approach.

Burns From Hot Wheat Bags: A Public Safety Issue

Science.gov (United States)

Collins, Anna; Amprayil, Mathew; Solanki, Nicholas S.; Greenwood, John Edward

2011-01-01

Introduction: Wheat bags are therapeutic devices that are heated in microwaves and commonly used to provide relief from muscle and joint pain. The Royal Adelaide Hospital Burns Unit has observed a number of patients with significant burn injuries resulting from their use. Despite their dangers, the products come with limited safety information. Methods: Data were collected from the Burns Unit database for all patients admitted with burns due to hot wheat bags from 2004 to 2009. This was analyzed to determine the severity of the burn injury and identify any predisposing factors. An experimental study was performed to measure the temperature of wheat bags when heated to determine their potential for causing thermal injury. Results: 11 patients were admitted with burns due to hot wheat bags. The median age was 52 years and the mean total body surface area was 1.1%. All burns were either deep dermal (45.5%) or full thickness (54.5%). Ten patients required operative management. Predisposing factors (eg, neuropathy) to thermal injury were identified in 7 patients. The experimental study showed that hot wheat bags reached temperatures of 57.3°C (135.1°F) when heated according to instructions, 63.3°C (145.9°F) in a 1000 W microwave and 69.6°C (157.3°F) on reheating. Conclusions: Hot wheat bags cause serious burn injury. When heated improperly, they can reach temperatures high enough to cause epidermal necrosis in a short period of time. Patients with impaired temperature sensation are particularly at risk. There should be greater public awareness of the dangers of wheat bag use and more specific safety warnings on the products. PMID:21915357

Marketing activities of vape shops across racial/ethnic communities

OpenAIRE

Garcίa, Robert; Sidhu, Anupreet; Allem, Jon-Patrick; Baezconde-Garbanati, Lourdes; Unger, Jennifer B.; Sussman, Steve

2017-01-01

INTRODUCTION There has been a surge in the number of vape shops in the USA. Research on the marketing practices of e-cigarette manufacturers is scarce and even less known are the practices of vape shop retailers. Past research on tobacco marketing has shown differences in the amount and content of marketing material, based on a community’s demographic profile. This study examined marketing strategies in vape shops and explored differences among vape shops located in communities that differ by...

Comparison of cryopreservation bags for hematopoietic progenitor cells using a WBC-enriched product.

Science.gov (United States)

Dijkstra-Tiekstra, Margriet J; Hazelaar, Sandra; Gkoumassi, Effimia; Weggemans, Margienus; de Wildt-Eggen, Janny

2015-04-01

Hematopoietic progenitor cells (HPC) are stored in cryopreservation bags that are resistant to liquid nitrogen. Since Cryocyte bags of Baxter (B-bags) are no longer available, an alternative bag was sought. Also, the influence of freezing volume was studied. Miltenyi Biotec (MB)- and MacoPharma (MP)-bags passed the integrity tests without failure. Comparing MB- and MP-bags with B-bags, no difference in WBC recovery or viability was found when using a WBC-enriched product as a "dummy" HPC product. Further, a freezing volume of 30 mL resulted in better WBC recovery and viability than 60 mL. Additonal studies using real HPC might be necessary. Copyright © 2014 Elsevier Ltd. All rights reserved.

Book Bag Buddies

Science.gov (United States)

Madden, Angie; Townsend, J. Scott; Green, Jennifer

2011-01-01

Children love to learn about new topics and share what they have discovered with their teachers, families, and friends. The authors designed the "Book Bag Buddies" project to give their third-grade students a chance to channel their enthusiasm and research from science investigations into writing. In this creative project, students integrated…

BAG1: the guardian of anti-apoptotic proteins in acute myeloid leukemia.

Directory of Open Access Journals (Sweden)

Sanja Aveic

Full Text Available BCL2 associated Athano-Gene 1 (BAG1 is a multifunctional protein that has been described to be involved in different cell processes linked to cell survival. It has been reported as deregulated in diverse cancer types. Here, BAG1 protein was found highly expressed in children with acute myeloid leukemia at diagnosis, and in a cohort of leukemic cell lines. A silencing approach was used for determining BAG1's role in AML, finding that its down-regulation decreased expression of BCL2, BCL-XL, MCL1, and phospho-ERK1/2, all proteins able to sustain leukemia, without affecting the pro-apoptotic protein BAX. BAG1 down-regulation was also found to increase expression of BAG3, whose similar activity was able to compensate the loss of function of BAG1. BAG1/BAG3 co-silencing caused an enhanced cell predisposition to death in cell lines and also in primary AML cultures, affecting the same proteins. Cell death was CASPASE-3 dependent, was accompanied by PARP cleavage and documented by an increased release of pro-apoptotic molecules Smac/DIABLO and Cytochrome c. BAG1 was found to directly maintain BCL2 and to protect MCL1 from proteasomal degradation by controlling USP9X expression, which appeared to be its novel target. Finally, BAG1 was found able to affect leukemia cell fate by influencing the expression of anti-apoptotic proteins crucial for AML maintenance.

Charges for plastic bags : Motivational and behavioral effects

NARCIS (Netherlands)

Jakovcevic, Adriana; Steg, Linda; Mazzeo, Nadia; Caballero, Romina; Franco, Paul; Putrino, Natalia; Favara, Jesica

2014-01-01

Two field studies tested the effects of a charge for single-use plastic bags recently implemented in Buenos Aires City, Argentina. Study 1 showed a greater increase in consumers' own bag use after the charge was introduced in supermarkets where the policy was introduced, in comparison to control

Zero-point energy in bag models

International Nuclear Information System (INIS)

Milton, K.A.

1979-01-01

The zero-point (Casimir) energy of free vector (gluon) fields confined to a spherical cavity (bag) is computed. With a suitable renormalization the result for eight gluons is E = + 0.51/a. This result is substantially larger than that for a spherical shell (where both interior and exterior modes are present), and so affects Johnson's model of the QCD vacuum. It is also smaller than, and of opposite sign to, the value used in bag model phenomenology, so it will have important implications there. 1 figure

Online versus conventional shopping: consumers' risk perception and regulatory focus.

Science.gov (United States)

van Noort, Guda; Kerkhof, Peter; Fennis, Bob M

2007-10-01

In two experiments, the impact of shopping context on consumers' risk perceptions and regulatory focus was examined. We predicted that individuals perceive an online (vs. conventional) shopping environment as more risky and that an online shopping environment, by its risky nature, primes a prevention focus. The findings in Study 1 demonstrate these effects by using self-report measures for risk perception and prevention focus. In Study 2, we replicated these findings and demonstrated that the effect of an online shopping environment carries over to behavior in a domain unrelated to shopping.

Performance of triple bagging hermetic technology for postharvest storage of cowpea grain in Niger

KAUST Repository

Baoua, Ibrahim B.

2012-10-01

Triple bagging technology for protecting postharvest cowpea grain from losses to the bruchid, Callosobruchus maculatus Fabricius (Coleoptera: Chrysomelidae: Bruchinae) is currently being adopted on a fairly large scale in ten West and Central African countries, including Niger. The triple bag consists of two inner high-density polyethylene bags acting as oxygen barriers, which in turn are encased in an outer woven polypropylene bag that serves primarily for mechanical strength. These hermetic bags, available in either 50 or 100 kg capacity, are called Purdue Improved Cowpea Storage (PICS) bags. Adoption of PICS technology in West and Central Africa has been driven by its effectiveness, simplicity, low cost, durability, and manufacture within the region. From surveys on adoption we discovered that farmers have begun to re-use bags they had used the previous year or even the previous two years. In the present study, we compared the performance of three different types of PICS bags: (1) new 50 kg (2) new 100 kg bags and (3) once-used 50 kg bags, all filled with naturally infested untreated cowpeas. In these PICS bags the O 2 levels within the bags initially fell to about 3 percent (v/v) while the CO 2 rose to nearly 5 percent (v/v). After five months of storage, new and used 50 kg bags and new 100 kg bags preserved the grain equally well. There were greatly reduced numbers of adults and larvae in the PICS bags versus the controls, which consisted of grain stored in single layer woven bags. The proportion of grain having C. maculatus emergence holes after five months of storage in PICS bags was little changed from that found when the grain was first put into the bags. The PICS technology is practical and useful in Sahelian conditions and can contribute to improved farmers\\' incomes as well as increase availability of high quality, insecticide-free cowpea grain as food. © 2012 Elsevier Ltd.

NON-FUNCTIONAL SHOPPING MOTIVES AMONG IRANIAN CONSUMERS

Directory of Open Access Journals (Sweden)

Shahriar AZIZI

2011-01-01

Full Text Available This study aims to explore the non functional shopping motives among Iranian consumers. In addition, the effects of marital status, gender, age and residential region as an indicator for social class on the non-functional shopping motives are investigated. This paper uses a self-reported and 15 items questionnaire. The analysis is done based on 363 returned and usable questionnaires. Multivariate analysis of variance is applied for this study. MANOVA results show that marital status, gender, age and region have different significant effects on the non-functional shopping motives among Iranian consumers.

Bag-breakup control of surface drag in hurricanes

Science.gov (United States)

Troitskaya, Yuliya; Zilitinkevich, Sergej; Kandaurov, Alexander; Ermakova, Olga; Kozlov, Dmitry; Sergeev, Daniil

2016-04-01

Air-sea interaction at extreme winds is of special interest now in connection with the problem of the sea surface drag reduction at the wind speed exceeding 30-35 m/s. This phenomenon predicted by Emanuel (1995) and confirmed by a number of field (e.g., Powell, et al, 2003) and laboratory (Donelan et al, 2004) experiments still waits its physical explanation. Several papers attributed the drag reduction to spume droplets - spray turning off the crests of breaking waves (e.g., Kudryavtsev, Makin, 2011, Bao, et al, 2011). The fluxes associated with the spray are determined by the rate of droplet production at the surface quantified by the sea spray generation function (SSGF), defined as the number of spray particles of radius r produced from the unit area of water surface in unit time. However, the mechanism of spume droplets' formation is unknown and empirical estimates of SSGF varied over six orders of magnitude; therefore, the production rate of large sea spray droplets is not adequately described and there are significant uncertainties in estimations of exchange processes in hurricanes. Herewith, it is unknown what is air-sea interface and how water is fragmented to spray at hurricane wind. Using high-speed video, we observed mechanisms of production of spume droplets at strong winds by high-speed video filming, investigated statistics and compared their efficiency. Experiments showed, that the generation of the spume droplets near the wave crest is caused by the following events: bursting of submerged bubbles, generation and breakup of "projections" and "bag breakup". Statistical analysis of results of these experiments showed that the main mechanism of spray-generation is attributed to "bag-breakup mechanism", namely, inflating and consequent blowing of short-lived, sail-like pieces of the water-surface film. Using high-speed video, we show that at hurricane winds the main mechanism of spray production is attributed to "bag-breakup", namely, inflating and

The use of filtered bags to increase waste payload capacity

International Nuclear Information System (INIS)

Dustin, D.F.; Thorp, D.T.; Rivera, M.A.

1998-01-01

For the past few years, the Department of Energy has favored the direct disposal of low plutonium content residue materials from Rocky Flats rather than engage in expensive and time consuming plutonium recovery operations. One impediment to direct disposal has been the wattage limit imposed by the Waste Isolation Pilot Plant on hydrogenous materials such as combustibles and sludges. The issue of concern is the radiolytic generation and accumulation of hydrogen and other explosive gases in waste containers. The wattage limits that existed through 1996 restricted the amount of plutonium bearing hydrogenous materials that could be packaged in a WIPP bound waste drum to only a fraction of the capacity of a drum. Typically, only about one kilogram of combustible residue could be packaged in a waste drum before the wattage limit was exceeded resulting in an excessively large number of drums to be procured, stored, shipped, and interred. The Rocky Flats Environmental Technology Site has initiated the use of filtered plastic bags (called bag-out bags) used to remove transuranic waste materials from glove box lines. The bags contain small, disk like HEPA filters which are effective in containing radioactively contaminated particulate material but allow for the diffusion of hydrogen gas. Used in conjunction with filtered 55 gallon drums, filtered bag-out bags were pursued as a means to increase the allowable wattage limits for selected residue materials. In February 1997, the Nuclear Regulatory Commission approved the use of filtered bag-out bags for transuranic waste materials destined for WIPP. The concomitant increase in wattage limits now allows for approximately four times the payload per waste drum for wattage limited materials

BAG3: a new player in the heart failure paradigm.

Science.gov (United States)

Knezevic, Tijana; Myers, Valerie D; Gordon, Jennifer; Tilley, Douglas G; Sharp, Thomas E; Wang, JuFang; Khalili, Kamel; Cheung, Joseph Y; Feldman, Arthur M

2015-07-01

BAG3 is a cellular protein that is expressed predominantly in skeletal and cardiac muscle but can also be found in the brain and in the peripheral nervous system. BAG3 functions in the cell include: serving as a co-chaperone with members of the heat-shock protein family of proteins to facilitate the removal of misfolded and degraded proteins, inhibiting apoptosis by interacting with Bcl2 and maintaining the structural integrity of the Z-disk in muscle by binding with CapZ. The importance of BAG3 in the homeostasis of myocytes and its role in the development of heart failure was evidenced by the finding that single allelic mutations in BAG3 were associated with familial dilated cardiomyopathy. Furthermore, significant decreases in the level of BAG3 have been found in end-stage failing human heart and in animal models of heart failure including mice with heart failure secondary to trans-aortic banding and in pigs after myocardial infarction. Thus, it becomes relevant to understand the cellular biology and molecular regulation of BAG3 expression in order to design new therapies for the treatment of patients with both hereditary and non-hereditary forms of dilated cardiomyopathy.

What drives people? Analyzing leisure-shopping trip decision making

NARCIS (Netherlands)

de Ceunynck, T.; Kusumastuti, Diana; Hannes, E.; Janssens, D.; Wets, G.

2011-01-01

Because of the strong increase in the number of leisure-shopping trips, a shift towards more sustainable leisure-shopping behaviour is desirable. This can be attained by having a better insight into people’s reasoning in choosing a transport mode and shopping location for this type of activities.

E-shopping and its interactions with in-store shopping

NARCIS (Netherlands)

Farag, Sendy

2006-01-01

Nowadays, the Internet permeates society: for many people, life without the Internet is hard to imagine. E-shopping (searching and/or buying products online) has rapidly gained popularity in the past few years, and could affect consumers’ visits to stores. The goal of this research is to show which

Analysis of BAG3 plasma concentrations in patients with acutely decompensated heart failure.

Science.gov (United States)

Gandhi, Parul U; Gaggin, Hanna K; Belcher, Arianna M; Harisiades, Jamie E; Basile, Anna; Falco, Antonia; Rosati, Alessandra; Piscione, Federico; Januzzi, James L; Turco, M Caterina

2015-05-20

BCL-2-associated athanogene 3 (BAG3) is a protein implicated in the cardiomyocyte stress response and genesis of cardiomyopathy. Extracellular BAG3 is measurable in patients with heart failure (HF), but the relationship of BAG3 with HF prognosis is unclear. BAG3 plasma concentrations were measured in 39 acutely decompensated HF patients; the primary endpoint was death at 1 year. Baseline characteristics were compared by vital status and median BAG3 concentration. Correlation of BAG3 with left ventricular ejection fraction (LVEF) and other biomarkers was performed. Prognostic value was assessed using Cox proportional hazards regression and Kaplan-Meier analysis. At baseline, median BAG3 was significantly higher in decedents (N=11) than survivors (N=28; 1489 ng/mL versus 50 ng/mL; P=0.04); decedents also had worse renal function and higher median natriuretic peptide (NP) and sST2. BAG3 was not significantly correlated with NPs, mid-regional pro-adrenomedullin, sST2, or eGFR, however. Mortality was increased in patients with supra-median BAG3 (>336 ng/mL; 42.1% versus 15.0%, P=0.06). In age and LVEF-adjusted Cox proportional hazards, BAG3 remained a significant mortality predictor (HR=3.20; 95% CI=1.34-7.65; P=0.02); those with supra-median BAG3 had significantly shorter time-to-death (P=0.04). The stress response protein BAG3 is measurable in patients with ADHF and may be prognostic for death. Copyright © 2015 Elsevier B.V. All rights reserved.

Apparel shopping behavior of elderly men and women.

Science.gov (United States)

Chowdhary, U

1989-06-01

70 interested elderly (65 yr. and over) men and women participated in an investigation of older consumers' apparel-shopping behavior and satisfactions and dissatisfactions with available clothing and facilities. Analysis showed that the participants considered shopping ease, wide variety, and label/brand as some of the important factors while shopping for clothes. The respondents were satisfied with good selection, closeness of the mall, and reasonable sales. However, their dissatisfactions ranged from service to fit and size, youthful styles, and abundance of imported clothing. In-store displays, mail order catalogs, and window shopping were the most commonly used sources of apparel information. Several implications of the findings were discussed and suggestions for further research were made.

Effect of pre-harvest fruit bagging on post-harvest quality of guava cv. Swarupkathi

Directory of Open Access Journals (Sweden)

Md. Mokter Hossain

2018-04-01

The investigation was carried out at Germplasm Centre (BAU-GPC, Bangladesh Agricultural University, during March to July 2016 in order to investigate the effect of pre-harvest fruit bagging on post-harvest quality of guava cv. Swarupkathi. Four different bagging materials viz. brown paper bag, white paper bag, white polythene bag, black polythene bag included for the study and uncovered fruits were used as control treatment. The experiment was laid out in randomized complete block design with three replications. Fruit bagging treatments showed significant effects on different parameters studied. It was observed that fruit size, fruit weight, vitamin C concentration, and moisture content increased due to fruit bagging. Fruits were gained maximum in size (6.59 cm length, 5.86 cm diameter and weight (164.26 g under white paper bag followed by white polythene bag (131.3g. The skin color of fruits was very attractive in case of white paper bag than that of other treatments. Total soluble solid concentration of the fruit was found maximum (12.33% Brix under brown paper bag while maximum vitamin C concentration (162.14 mg 100 g-1 was recorded under white paper bag. Uncovered fruits showed maximum total sugar, non-reducing sugar, reducing sugar concentrations (10.13%, 6.05%, 4.08%, respectively.The results revealed that fruit bagging in general, improved the growth and quality of guava fruits as compared to control. Among the various fruit covering materials, white paper bag was found to be the best for overall improvement of physical and chemical quality of guava cv. Swarupkathi. [Fundam Appl Agric 2018; 3(1.000: 363-371

An alternative approach to heavy quark bags

International Nuclear Information System (INIS)

Baacke, J.; Kasperidus, G.

1980-01-01

We discuss a formulation of quark bags where the quark wave function depends only on the relative coordinate and the bag boundary is fixed with respect to the center of mass of the quark system. For technical reasons we have to restrict ourselves to a heavy quark-antiquark system in an s-wave with spherical boundary. A phenomenological application to quarkonium states encourages further investigation of the approach. (orig.)

Wave energy absorption by a submerged air bag connected to a rigid float

DEFF Research Database (Denmark)

Kurniawan, Adi; Chaplin, J. R.; Hann, M. R.

2017-01-01

A new wave energy device features a submerged ballasted air bag connected at the top to a rigid float. Under wave action, the bag expands and contracts, creating a reciprocating air flow through a turbine between the bag and another volume housed within the float. Laboratory measurements are gene......A new wave energy device features a submerged ballasted air bag connected at the top to a rigid float. Under wave action, the bag expands and contracts, creating a reciprocating air flow through a turbine between the bag and another volume housed within the float. Laboratory measurements...

Energy efficiency in U.K. shopping centres

Science.gov (United States)

Mangiarotti, Michela

Energy efficiency in shopping centres means providing comfortable internal environment and services to the occupants with minimum energy use in a cost-effective and environmentally sensitive manner. This research considers the interaction of three factors affecting the energy efficiency of shopping centres: i) performance of the building fabric and services ii) management of the building in terms of operation, control, maintenance and replacement of the building fabric and services, and company's energy policy iii) occupants' expectation for comfort and awareness of energy efficiency. The aim of the investigation is to determine the role of the above factors in the energy consumption and carbon emissions of shopping centres and the scope for reducing this energy usage by changing one or all the three factors. The study also attempts to prioritize the changes in the above factors that are more cost-effective at reducing that energy consumption and identify the benefits and main economic and legal drivers for energy efficiency in shopping centres. To achieve these targets, three case studies have been analysed. Using energy data from bills, the performance of the selected case studies has been assessed to establish trends and current energy consumption and carbon emissions of shopping centres and their related causes. A regression analysis has attempted to break down the energy consumption of the landlords' area by end-use to identify the main sources of energy usage and consequently introduce cost-effective measures for saving energy. A monitoring and occupants' survey in both landlords' and tenants' areas have been carried out at the same time to compare the objective data of the environmental conditions with the subjective impressions of shoppers and shopkeepers. In particular, the monitoring aimed at assessing the internal environment to identify possible causes of discomfort and opportunities for introducing energy saving measures. The survey looked at

Modern status of quark bag model

International Nuclear Information System (INIS)

Bogolyubov, P.N.; Dorokhov, A.E.

1987-01-01

A review contains a modern status of the bag model - a composite quark model of hadrons. The idea of quasi-independent quarks moving in a finite closed region of space is a basic feature of the model. Dubna's formulation of the model and its different versions (MIT, chiral model and others) are given in detail. The role of symmetric and physical principles of the model is underlined, a critical review of mass formulas is given, the relation of the bag model and the soliton-like models (in particular with the Skyrme model) is considered

Cue reactivity towards shopping cues in female participants.

Science.gov (United States)

Starcke, Katrin; Schlereth, Berenike; Domass, Debora; Schöler, Tobias; Brand, Matthias

2013-03-01

Background and aims It is currently under debate whether pathological buying can be considered as a behavioural addiction. Addictions have often been investigated with cue-reactivity paradigms to assess subjective, physiological and neural craving reactions. The current study aims at testing whether cue reactivity towards shopping cues is related to pathological buying tendencies. Methods A sample of 66 non-clinical female participants rated shopping related pictures concerning valence, arousal, and subjective craving. In a subgroup of 26 participants, electrodermal reactions towards those pictures were additionally assessed. Furthermore, all participants were screened concerning pathological buying tendencies and baseline craving for shopping. Results Results indicate a relationship between the subjective ratings of the shopping cues and pathological buying tendencies, even if baseline craving for shopping was controlled for. Electrodermal reactions were partly related to the subjective ratings of the cues. Conclusions Cue reactivity may be a potential correlate of pathological buying tendencies. Thus, pathological buying may be accompanied by craving reactions towards shopping cues. Results support the assumption that pathological buying can be considered as a behavioural addiction. From a methodological point of view, results support the view that the cue-reactivity paradigm is suited for the investigation of craving reactions in pathological buying and future studies should implement this paradigm in clinical samples.

ShopGirls Shine in Eco-Marathon

Science.gov (United States)

Stowell, Shante

2011-01-01

The ShopGirls of Granite Falls (WA) High School are the first-ever all-female team to successfully design, build, and race a prototype diesel car in the Shell Eco-marathon. The team took first place in the diesel fuel-efficiency category with a vehicle that achieved 470 miles per gallon! The idea for the ShopGirls came when Vervia Gabriel, career…

The impact of science shops on university research and education

DEFF Research Database (Denmark)

Jørgensen, Michael Søgaard

2000-01-01

Science shops are mediating agencies at universities that give citizens and citizen groups access to the resources of the university through co-operation with students and researchers. Science shops have three aims: to support citizens and citizen groups in their efforts getting influence...... to the impact of science shops on universities and on society are discussed. A typology for the different types of knowledge requested by citizens and citizen groups through science shops is presented (documentation, knowledge building, development of new perspectives). As important aspects of the potentials......, prerequisites and limits to the impact of science shops are discussed the networking between the science shop and the researchers and teachers and with the citizens and other external actors, and the content and the structure of the curricula at the university....

Consumer protection and internet shopping

OpenAIRE

Blažková, Lenka

2010-01-01

The diploma thesis is devoted to the issue of online shopping. Its aim is to analyze internet shopping and see the rights and obligations of consumers and sellers, which are based on current legislation. The thesis is divided into two parts. The theoretical part deals with purchase over the internet and its regulations. There are explained the concepts internet, e-business and e-commerce and indicate the types of e-business and is mentioned certification of online stores. The practical part i...

Comparison of bacterial attachment to platelet bags with and without preconditioning with plasma.

Science.gov (United States)

Loza-Correa, M; Kalab, M; Yi, Q-L; Eltringham-Smith, L J; Sheffield, W P; Ramirez-Arcos, S

2017-07-01

Canadian Blood Services produces apheresis and buffy coat pooled platelet concentrates (PCs) stored in bags produced by two different manufacturers (A and B, respectively), both made of polyvinyl chloride-butyryl trihexyl citrate. This study was aimed at comparing Staphylococcus epidermidis adhesion to the inner surface of both bag types in the presence or absence of plasma factors. Sets (N = 2-6) of bags type A and B were left non-coated (control) or preconditioned with platelet-rich, platelet-poor or defibrinated plasma (PRP, PPP and DefibPPP, respectively). Each bag was inoculated with a 200-ml S. epidermidis culture adjusted to 0·5 colony-forming units/ml. Bags were incubated under platelet storage conditions for 7 days. After culture removal, bacteria attached to the plastic surface were either dislodged by sonication for bacterial quantification or examined in situ by scanning electron microscopy (SEM). Higher bacterial adhesion was observed to preconditioned PC bags than control containers for both bag types (P bags was confirmed by SEM. Bacteria adhered equally to both types of containers in the presence of PRP, PPP and DefibPPP residues (P > 0·05). By contrast, a significant increase in bacterial adherence was observed to type A bags compared with type B bags in the absence of plasma (P bags depends on the presence of plasma factors. Future efforts should be focused on reducing plasma proteins' attachment to platelet storage containers to decrease subsequent bacterial adhesion. © 2017 International Society of Blood Transfusion.

Stability of odorants from pig production in sampling bags for olfactometry.

Science.gov (United States)

Hansen, Michael J; Adamsen, Anders P S; Feilberg, Anders; Jonassen, Kristoffer E N

2011-01-01

Odor from pig production facilities is typically measured with olfactometry, whereby odor samples are collected in sampling bags and assessed by human panelists within 30 h. In the present study, the storage stability of odorants in two types of sampling bags that are often used for olfactometry was investigated. The bags were made of Tedlar or Nalophan. In a field experiment, humid and dried air samples were collected from a pig production facility with growing-finishing pigs and analyzed with a gas chromatograph with an amperometric sulfur detector at 4, 8, 12, 28, 52, and 76 h after sampling. In a laboratory experiment, the bags were filled with a humid gas mixture containing carboxylic acids, phenols, indoles, and sulfur compounds and analyzed with proton-transfer-reaction mass spectrometry after 0, 4, 8, 12, and 24 h. The results demonstrated that the concentrations of carboxylic acids, phenols, and indoles decreased by 50 to >99% during the 24 h of storage in Tedlar and Nalophan bags. The concentration of hydrogen sulfide decreased by approximately 30% during the 24 h of storage in Nalophan bags, whereas in Tedlar bags the concentration of sulfur compounds decreased by bags, and the composition changes toward a higher relative presence of sulfur compounds. This can result in underestimation of odor emissions from pig production facilities and of the effect of odor reduction technologies. Copyright © by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.

Doctor and pharmacy shopping for controlled substances.

Science.gov (United States)

Peirce, Gretchen L; Smith, Michael J; Abate, Marie A; Halverson, Joel

2012-06-01

Prescription drug abuse is a major health concern nationwide, with West Virginia having one of the highest prescription drug death rates in the United States. Studies are lacking that compare living subjects with persons who died from drug overdose for evidence of doctor and pharmacy shopping for controlled substances. The study objectives were to compare deceased and living subjects in West Virginia for evidence of prior doctor and pharmacy shopping for controlled substances and to identify factors associated with drug-related death. A secondary data study was conducted using controlled substance, Schedule II-IV, prescription data from the West Virginia Controlled Substance Monitoring Program and drug-related death data compiled by the Forensic Drug Database between July 2005 and December 2007. A case-control design compared deceased subjects 18 years and older whose death was drug related with living subjects for prior doctor and pharmacy shopping. Logistic regression identified factors related to the odds of drug-related death. A significantly greater proportion of deceased subjects were doctor shoppers (25.21% vs. 3.58%) and pharmacy shoppers (17.48% vs. 1.30%) than living subjects. Approximately 20.23% of doctor shoppers were also pharmacy shoppers, and 55.60% of pharmacy shoppers were doctor shoppers. Younger age, greater number of prescriptions dispensed, exposure to opioids and benzodiazepines, and doctor and pharmacy shopping were factors with greater odds of drug-related death. Doctor and pharmacy shopping involving controlled substances were identified, and shopping behavior was associated with drug-related death. Prescription monitoring programs may be useful in identifying potential shoppers at the point of care.

In vitro digestibility of lucerne hay using bag method

Directory of Open Access Journals (Sweden)

constantin gavan

2013-10-01

Full Text Available A filter bag method was used for estimating apparent dry matter (DM digestibility, apparent digestible organic matter in DM, true DM digestibility, true digestible organic matter in DM and Digestibility of neutral detergent fibre. The forage sample analysed comprised tree plant parts (whole, leaf and stem of alfalfa (Medicago sativa, one degree of particle breakdown (1 mm sieve size at miliing and two field replicates at Agricultural Research and Developement Station (ARDS Șimnic-Craiova. Rumen fluid was used from two cannulated dairy cows. The use of filter bags can give acceptable results for the in vitro digestibility of forages. The escape of soluble matter from bags with samples high in solubles could influence the microbial population and hence increase cell wall degradation in bags with samples low in soluble matter, if  all are in the same incubation vessel.

Hospital discharge bags and breastfeeding at 6 months: data from the infant feeding practices study II.

Science.gov (United States)

Sadacharan, Radha; Grossman, Xena; Matlak, Stephanie; Merewood, Anne

2014-02-01

Distribution of industry-sponsored formula sample packs to new mothers undermines breastfeeding. Using data from the Infant Feeding Practices Study II (IFPS II), we aimed to determine whether receipt of 4 different types of bags was associated with exclusive breastfeeding during the first 6 months of life. We extracted data from IFPS II questionnaires. Type of discharge bag received was categorized as "formula bag," "coupon bag," "breastfeeding supplies bag," or "no bag". We examined exclusive breastfeeding status at 10 weeks (post hoc) and at 6 months using univariate descriptive analyses and multivariate logistic regression models, controlling for sociodemographic and attitudinal variables. Overall, 1868 (81.4%) of women received formula bags, 96 (4.2%) received coupon bags, 46 (2.0%) received breastfeeding supplies bags, and 284 (12.4%) received no bag. By 10 weeks, recipients of breastfeeding supplies bags or no bag were significantly more likely to be exclusively breastfeeding than formula bag recipients. In the adjusted model, compared to formula bag/coupon bag recipients, recipients of breastfeeding supplies bag/no bag were significantly more likely to breastfeed exclusively for 6 months (odds ratio = 1.58; 95% confidence interval, 1.06-2.36). The vast majority of new mothers received formula sample packs at discharge, and this was associated with reduced exclusive breastfeeding at 10 weeks and 6 months. Bags containing breastfeeding supplies or no bag at all were positively associated with exclusive breastfeeding at 10 weeks and 6 months.

Testing odorants recovery from a novel metallized fluorinated ethylene propylene gas sampling bag.

Science.gov (United States)

Zhu, Wenda; Koziel, Jacek A; Cai, Lingshuang; Wright, Donald; Kuhrt, Fred

2015-12-01

Industry-standard Tedlar bags for odor sample collection from confined animal feeding operations (CAFOs) have been challenged by the evidence of volatile organic compound (VOC) losses and background interferences. Novel impermeable aluminum foil with a thin layer of fluorinated ethylene propylene (FEP) film on the surface that is in contact with a gas sample was developed to address this challenge. In this research, Tedlar and metallized FEP bags were compared for (a) recoveries of four characteristic CAFO odorous VOCs (ethyl mercaptan, butyric acid, isovaleric acid and p-cresol) after 30 min and 24 hr sample storage time and for (b) chemical background interferences. All air sampling and analyses were performed with solid-phase microextraction (SPME) followed by gas chromatography-mass spectroscopy (GC-MS). Mean target gas sample recoveries from metallized FEP bags were 25.9% and 28.0% higher than those in Tedlar bags, for 30 min and 24 hr, respectively. Metallized FEP bags demonstrated the highest p-cresol recoveries after 30-min and 24-hr storage, 96.1±44.5% and 44.8±10.2%, respectively, among different types of sampling bags reported in previous studies. However, a higher variability was observed for p-cresol recovery with metallized FEP bags. A 0% recovery of ethyl mercaptan was observed with Tedlar bags after 24-hr storage, whereas an 85.7±7.4% recovery was achieved with metallized FEP bags. Recoveries of butyric and isovaleric acids were similar for both bag types. Two major impurities in Tedlar bags' background were identified as N,N-dimethylacetamide and phenol, while backgrounds of metallized FEP bags were significantly cleaner. Reusability of metallized FEP bags was tested. Caution is advised when using polymeric materials for storage of livestock-relevant odorous volatile organic compounds. The odorants loss with storage time confirmed that long-term storage in whole-air form is ill advised. A focused short-term odor sample containment should be

Design-A-Bag Competition 2012

Index Scriptorium Estoniae

2012-01-01

Eesti Kunstiakadeemia nahakunsti osakonna tudengid Kadri Paloveer, Inga Radikainen ja Mari Maripuu pälvisid Hong-Kongis korraldataval "DESIGN-A-BAG 2012" konkursil tihedas rahvusvahelises konkurentsis mitmeid preemiaid

Overexpression of BAG3 Attenuates Hypoxia-Induced Cardiomyocyte Apoptosis by Inducing Autophagy

Directory of Open Access Journals (Sweden)

Jiankai Zhang

2016-07-01

Full Text Available Background: Hypoxia is a well-known factor in the promotion of apoptosis, which contributes to the development of numerous cardiac diseases, such as heart failure and myocardial infarction. Inhibiting apoptosis is an important therapeutic strategy for the treatment of related heart diseases caused by ischemia/hypoxic injury. Previous studies have demonstrated that BAG3 plays an important role in cardiomyocyte apoptosis and survival. However, the role of BAG3 in hypoxia-induced cardiomyocyte apoptosis remains to be clarified. Here, we demonstrate that BAG3 is induced by hypoxia stimuli in cultured cardiomyocytes. Methods: BAG3 expression level was measured in H9c2 cells treated with hypoxia for 48 h. Cell proliferation and apoptosis were tested using MTT assay and Annexin V FITC-PI staining assay, respectively. The mRNA or protein expression level of BAG3, LC3-I, LC3-II, Atg5, NF-κB p65 and phosphorylated NF-κB p65 were assessed by qRT-PCR and western blot assay, respectively. Resluts: Overexpression of BAG3 inhibited cell apoptosis and promoted proliferation in hypoxia-injured H9c2 cells. Furthermore, autophagy and NF-κB were activated by BAG3 overexpression, and the NF-κB inhibitor PDTC could inhibit the activation of autophagy induced by BAG3 overexpression. In addition, the autophagy inhibitor 3-MA partly impeded the inhibitory effect of BAG3 on hypoxia-induced cardiomyocyte apoptosis. Conclusion: these results suggested that overexpression of BAG3 promoted cell proliferation and inhibited apoptosis by activating autophagy though the NF-κB signaling pathway in hypoxia-injured cardiomyocytes.

BAG3 regulates cell proliferation, migration, and invasion in human colorectal cancer.

Science.gov (United States)

Shi, Huiyong; Xu, Haidong; Li, Zengjun; Zhen, Yanan; Wang, Bin; Huo, Shoujun; Xiao, Ruixue; Xu, Zhongfa

2016-04-01

Bcl2-associated athanogene 3 (BAG3) has been reported to be elevated in various tumors. However, it is unclear whether BAG3 has a functional role in the initiation and progression of colorectal cancer (CRC). Here, we collected CRC samples and cell lines to validate the pathway by using gene and protein assays. RT-PCR showed that the expression of BAG3 mRNA in CRC tissues was obviously higher than that in non-tumor tissues (p BAG3 was found in most CRC tissues and strongly correlated with TNM stage (p = 0.001), differentiation (p = 0.003), and metastasis (p = 0.010). Low expression of BAG3 in HCT-8 significantly reduced cellular proliferation, migration, and invasion. The analysis of in vitro cell showed that HCT-8 cells were exposed to si-BAG3, and its growth was inhibited depending on modulation of cell cycle G1/S checkpoints and cell cycle regulators, involving cyclin D1, cyclin A2, and cyclin B1. Furthermore, suppression of the epithelial-mesenchymal transition (EMT) by si-BAG3 is linked to the decreased expression of E-cadherin and the increased expression of N-cadherin, vimentin, and MMP9. In conclusion, in the present study, we demonstrated that BAG3 overexpression plays a critical role in cell proliferation, migration, and invasion of colorectal cancer. Our data suggests targeted inhibition of BAG3 may be useful for patients with CRC.

Development of Spray on Bag for manufacturing of large composites parts: Diffusivity analysis

Science.gov (United States)

Dempah, Maxime Joseph

Bagging materials are utilized in many composites manufacturing processes. The selection is mainly driven by cost, temperature requirements, chemical compatibility and tear properties of the bag. The air barrier properties of the bag are assumed to be adequate or in many cases are not considered at all. However, the gas barrier property of a bag is the most critical parameter, as it can negatively affect the quality of the final laminate. The barrier property is a function of the bag material, uniformity, thickness and temperature. Improved barrier properties are needed for large parts, high pressure consolidated components and structures where air stays entrapped on the part surface. The air resistance property of the film is defined as permeability and is investigated in this thesis. A model was developed to evaluate the gas transport through the film and an experimental cell was implemented to characterize various commercial films. Understanding and characterizing the transport phenomena through the film allows optimization of the bagging material for various manufacturing processes. Spray-on-Bag is a scalable alternative bagging method compared to standard films. The approach allows in-situ fabrication of the bag on large and complex geometry structures where optimization of the bag properties can be varied on a local level. An experimental setup was developed and implemented using a six axis robot and an automated spraying system. Experiments were performed on a flat surface and specimens were characterized and compared to conventional films. Air barrier properties were within range of standard film approaches showing the potential to fabricate net shape bagging structures in an automated process.

Lipid globule size in total nutrient admixtures prepared in three-chamber plastic bags.

Science.gov (United States)

Driscoll, David F; Thoma, Andrea; Franke, Rolf; Klütsch, Karsten; Nehne, Jörg; Bistrian, Bruce R

2009-04-01

The stability of injectable lipid emulsions in three-chamber plastic (3CP) bags, applying the globule-size limits established by United States Pharmacopeia ( USP ) chapter 729, was studied. A total of five premixed total nutrient admixture (TNA) products packaged in 3CP bags from two different lipid manufacturers containing either 20% soybean oil or a mixture of soybean oil and medium-chain-triglyceride oil as injectable lipid emulsions were tested. Two low-osmolarity 3CP bags and three high-osmolarity 3CP bags were studied. All products were tested with the addition of trace elements and multivitamins. All additive conditions (with and without electrolytes) were tested in triplicate at time 0 (immediately after mixing) and at 6, 24, 30, and 48 hours after mixing; the bags were stored at 24-26 degrees C. All additives were equally distributed in each bag for comparative testing, applying both globule sizing methods outlined in USP chapter 729. Of the bags tested, all bags from one manufacturer were coarse emulsions, showing signs of significant growth in the large-diameter tail when mixed as a TNA formulation and failing the limits set by method II of USP chapter 729 from the outset and throughout the study, while the bags from the other manufacturer were fine emulsions and met these limits. Of the bags that failed, significant instability was noted in one series containing additional electrolytes. Injectable lipid emulsions provided in 3CP bags that did not meet the globule-size limits of USP chapter 729 produced coarser TNA formulations than emulsions that met the USP limits.

WW domain of BAG3 is required for the induction of autophagy in glioma cells.

Science.gov (United States)

Merabova, Nana; Sariyer, Ilker Kudret; Saribas, A Sami; Knezevic, Tijana; Gordon, Jennifer; Turco, M Caterina; Rosati, Alessandra; Weaver, Michael; Landry, Jacques; Khalili, Kamel

2015-04-01

Autophagy is an evolutionarily conserved, selective degradation pathway of cellular components that is important for cell homeostasis under healthy and pathologic conditions. Here we demonstrate that an increase in the level of BAG3 results in stimulation of autophagy in glioblastoma cells. BAG3 is a member of a co-chaperone family of proteins that associates with Hsp70 through a conserved BAG domain positioned near the C-terminus of the protein. Expression of BAG3 is induced by a variety of environmental changes that cause stress to cells. Our results show that BAG3 overexpression induces autophagy in glioma cells. Interestingly, inhibition of the proteasome caused an increase in BAG3 levels and induced autophagy. Further analysis using specific siRNA against BAG3 suggests that autophagic activation due to proteosomal inhibition is mediated by BAG3. Analyses of BAG3 domain mutants suggest that the WW domain of BAG3 is crucial for the induction of autophagy. BAG3 overexpression also increased the interaction between Bcl2 and Beclin-1, instead of disrupting them, suggesting that BAG3 induced autophagy is Beclin-1 independent. These observations reveal a novel role for the WW domain of BAG3 in the regulation of autophagy. © 2014 Wiley Periodicals, Inc.

Effects of Website Interactivity on Online Retail Shopping Behavior

Science.gov (United States)

Islam, Hafizul

Motivations to engage in retail online shopping can include both utilitarian and hedonic shopping dimensions. To cater to these consumers, online retailers can create a cognitively and esthetically rich shopping environment, through sophisticated levels of interactive web utilities and features, offering not only utilitarian benefits and attributes but also providing hedonic benefits of enjoyment. Since the effect of interactive websites has proven to stimulate online consumer’s perceptions, this study presumes that websites with multimedia rich interactive utilities and features can influence online consumers’ shopping motivations and entice them to modify or even transform their original shopping predispositions by providing them with attractive and enhanced interactive features and controls, thus generating a positive attitude towards products and services offered by the retailer. This study seeks to explore the effects of Web interactivity on online consumer behavior through an attitudinal model of technology acceptance.

Online shopping behavior in offline retail stores : strategic value for companies?

OpenAIRE

Ferreira, José Pedro Santos

2015-01-01

In a world where e-tailing and traditional in-store shopping live together and complement each other in several shopping activities (Chu, et. al, 2010), little is known about the possibility of an emerging reality in which online and offline shopping merge into one single phenomenon. The purpose of this dissertation is to explore whether consumers are willing to engage in a shopping behavior inside retail stores in a way that is similar to the one they have when shopping online. Additionally,...

BAG3 facilitates the clearance of endogenous tau in primary neurons.

Science.gov (United States)

Lei, Zhinian; Brizzee, Corey; Johnson, Gail V W

2015-01-01

Tau is a microtubule associated protein that is found primarily in neurons, and in pathologic conditions, such as Alzheimer's disease (AD) it accumulates and contributes to the disease process. Because tau plays a fundamental role in the pathogenesis of AD and other tauopathies, and in AD mouse models reducing tau levels improves outcomes, approaches that facilitate tau clearance are being considered as therapeutic strategies. However, fundamental to the development of such interventions is a clearer understanding of the mechanisms that regulate tau clearance. Here, we report a novel mechanism of tau degradation mediated by the co-chaperone BAG3. BAG3 has been shown to be an essential component of a complex that targets substrates to the autophagy pathway for degradation. In rat primary neurons, activation of autophagy by inhibition of proteasome activity or treatment with trehalose resulted in significant decreases in tau and phospho-tau levels. These treatments also induced an upregulation of BAG3. Proteasome inhibition activated JNK, which was responsible for the upregulation of BAG3 and increased tau clearance. Inhibiting JNK or knocking down BAG3 blocked the proteasome inhibition-induced decreases in tau. Further, BAG3 overexpression alone resulted in significant decreases in tau and phospho-tau levels in neurons. These results indicate that BAG3 plays a critical role in regulating the levels of tau in neurons, and interventions that increase BAG3 levels could provide a therapeutic approach in the treatment of AD. Copyright © 2015 Elsevier Inc. All rights reserved.

English Shop Signs and Brand Names

Directory of Open Access Journals (Sweden)

Parvaneh Khosravizadeh

2016-07-01

Full Text Available The present study tries to investigate the people’s attitude to the use of English words in TV commercials, brand-naming and shop signs in Iran and specifically in Tehran where due to the fact that it is the capital, more English might be used for the sake of foreigners. The widespread use of English shop signs and English brand names for recently produced goodsdrove the researchers to investigate peoples’ attitude as consumers from two aspects of age and education. To reach the research goal, a questionnaire was devised and distributed to 100 people at random selection probing their attitudes while considering two factors of age and education. The result of the research will mostly benefit sociolinguists and business marketers.Keywords: age, education, advertising, brand-naming, shop signs, globalization

E-commerce factors influencing consumers‘ online shopping decision

OpenAIRE

Baubonienė, Živilė; Gulevičiūtė, Gintarė

2015-01-01

Purpose – The purpose of this paper is to look at the factors driving online shopping and to develop an understanding of the factors influencing the online shopping by the consumers. This is done by exploring the factors that encourage consumers to shop online through analysis of such advantages as security, fast delivery, comparable price, convenience, cheaper prices and a wider choice. At the same time, the research project reveals the factors that are discouraging for consumers and the ben...

Customer Buying Behavior : - Online shopping towards electronic product

OpenAIRE

Wang, Dan; Yang, Liuzi

2010-01-01

ABSTRACT Online shopping in EU has been shown to a good potential market. The electronic equipment takes a high percent of the individuals shopping. Compared with other goods, online shopping of electronic goods adds great convenience to the life of the people. Buying electronic gadgets online gives customers an opportunity to find a great variety of product online, and customers can review a wide selection of products and find special offers and discount with the best deals online. In the co...

Online versus conventional shopping: Consumers' risk perception and regulatory focus

NARCIS (Netherlands)

van Noort, G.; Kerkhof, P.; Fennis, B.M.

2007-01-01

In two experiments, the impact of shopping context on consumers' risk perceptions and regulatory focus was examined. We predicted that individuals perceive an online (vs. conventional) shopping environment as more risky and that an online shopping environment, by its risky nature, primes a

Online versus Conventional Shopping: Consumers' Risk Perception and Regulatory Focus

NARCIS (Netherlands)

van Noort, Guda; Kerkhof, Peter; Fennis, B.M.

2007-01-01

In two experiments, the impact of shopping context on consumers' risk perceptions and regulatory focus was examined. We predicted that individuals perceive an online (vs. conventional) shopping environment as more risky and that an online shopping environment, by its risky nature, primes a

A Strategic Planning for a College Student-Segment Shopping Mall

OpenAIRE

Astri Anindya Sari; Hanson Endra Kusuma; Baskoro Tedjo

2011-01-01

In the midst of shopping mall development today, an understanding of consumer behaviors and preferences is absolutely a must if we want to plan successfuly a shopping mall. This knowledge will provide input for strategic planning so that the concept offered for shopping mall development will meet the consumers’ demand and may win the market competition. This study explores the preferences of students in Bandung as one of the potential market segments of the shopping mall. Qualitative study w...

[Evaluation of Storage Performance of Preserving Bags for Manually Separated Platelets].

Science.gov (United States)

Liu, Min-Xia; Duan, Lan; Wang, Jie-Xi; Wang, Yan; Zhuo, Hai-Long; Cai, Li-Na; Yi, Xiao-Yang; Zhou, Jian-Wei; Ang, Jian-Wei; Han, Ying

2015-08-01

To evaluate the storage performance of the domestically made platelet storage bags (experimental group) and the United States Trima set platelet storage bags (control group). The manually separated platelets were divided in two equal parts, which was added to control blood bags and experimental blood bags respectively, all samples were stored at a 22 °C ± 2 °C. The platelet count, mean volume, aggregation activity (ADP, THR), pH, glucose, lactate concentration, lactate dehydrogenase concentration, hypotonic shock reaction, CD62P and phosphatidic acid serine content were detected at day 0, 3, 5 and 7 of storage. There was no significant difference of platelet quality at day 5 after storage between the experimental group and the control group (T-test, P > 0.05). Two kinds of platelet storage bags have the similar storage performance.

Dimerization Products of Chloroprene are Background Contaminants Emitted from ALTEF (Polyvinylidene Difluoride) Gas Sampling Bags.

Science.gov (United States)

Kwak, Jae; Fan, Maomian; Martin, Jennifer A; Ott, Darrin K; Grigsby, Claude C

2017-01-01

Gas sampling bags have been used for collecting air samples. Tedlar bags are most commonly used, but bleed background chemicals such as N,N-dimethylacetamide and phenol. It is often necessary to remove the contaminant by flushing the bags with pure nitrogen or air. In this study, we identified four chloroprene dimerization products as background contaminants emitted from ALTEF bags that are made of a proprietary polyvinylidene difluoride (PVDF). No monomer chloroprene was detected in the bags analyzed. All of the dimers gradually increased once bags were filled with nitrogen due to diffusion from the bag surface. Flushing the bags with nitrogen reduced their concentrations, but was not effective for removing the contaminants. When the bags that had been flushed with nitrogen 5 times were left for 24 h, they increased again, indicating that the dimers were constantly emitted from the ALTEF bag surface. To our knowledge, these compounds have never been demonstrated in ALTEF or other PVDF bags. Our finding indicates that ALTEF might be incorporated with Neoprene (chloroprene-based polymer) during its manufacturing process.

Promoting fertilizer use via controlled release of a bacteria-encapsulated film bag.

Science.gov (United States)

Wu, Chin-San

2010-05-26

A phosphate-solubilizing bacterium ( Burkholderia cepacia isolate) encapsulated in maleic anhydride (MA) grafted onto poly(butylene succinate adipate) (PBSA) and then combined with starch as film bag material (PBSA-g-MA/starch) incubated in a saline solution required approximately 20 days to deplete the starch in the film bags. Thereafter, the cell concentration in the saline solution increased significantly because of the release of cells from the severely destroyed film bags and also their growth by use of depolymerized PBSA-g-MA fragments as a substrate. The incubation proceeded for 60 days, by which time the PBSA-g-MA/starch composite had suffered a >80% weight loss. For practical application, effectiveness of the above-mentioned film bags was demonstrated because it could improve the absorbability of a fertilizer for plants and promote the growth of plants. As a result, it can avoid the accumulation of the phosphate in excess fertilizer that lead to the phenomenon of poor soils. These results demonstrate that PBSA-g-MA/starch can be used to encapsulate cells of an indigenous phosphate-solubilizing bacterium ( B. cepacia isolate) to form a controlled release of bacteria-encapsulated film bag (BEFB). The B. cepacia isolate was able to degrade the film bags material, causing cell release. Biodegradability of the film bags depended upon the type of material used, because the PBSA film bags were also degraded but to a lesser degree. The addition of starch made the film bags more biodegradable. The decrease in intrinsic viscosity was also higher for the starch composite, suggesting a strong connection between the biodegradability and these characteristics. The results suggest that the release of fertilizer-promoted bacteria might be controllable via a suitable film bag material formulation. In addition, this work adopted live bacteria to promote the absorption of phosphate, which is superior to the phosphate used in the traditional way.

Overexpression of BAG3 Attenuates Hypoxia-Induced Cardiomyocyte Apoptosis by Inducing Autophagy.

Science.gov (United States)

Zhang, Jiankai; He, Zhangyou; Xiao, Wenjian; Na, Qingqing; Wu, Tianxiu; Su, Kaixin; Cui, Xiaojun

2016-01-01

Hypoxia is a well-known factor in the promotion of apoptosis, which contributes to the development of numerous cardiac diseases, such as heart failure and myocardial infarction. Inhibiting apoptosis is an important therapeutic strategy for the treatment of related heart diseases caused by ischemia/hypoxic injury. Previous studies have demonstrated that BAG3 plays an important role in cardiomyocyte apoptosis and survival. However, the role of BAG3 in hypoxia-induced cardiomyocyte apoptosis remains to be clarified. Here, we demonstrate that BAG3 is induced by hypoxia stimuli in cultured cardiomyocytes. BAG3 expression level was measured in H9c2 cells treated with hypoxia for 48 h. Cell proliferation and apoptosis were tested using MTT assay and Annexin V FITC-PI staining assay, respectively. The mRNA or protein expression level of BAG3, LC3-I, LC3-II, Atg5, NF-x03BA;B p65 and phosphorylated NF-x03BA;B p65 were assessed by qRT-PCR and western blot assay, respectively. Resluts: Overexpression of BAG3 inhibited cell apoptosis and promoted proliferation in hypoxia-injured H9c2 cells. Furthermore, autophagy and NF-x03BA;B were activated by BAG3 overexpression, and the NF-x03BA;B inhibitor PDTC could inhibit the activation of autophagy induced by BAG3 overexpression. In addition, the autophagy inhibitor 3-MA partly impeded the inhibitory effect of BAG3 on hypoxia-induced cardiomyocyte apoptosis. these results suggested that overexpression of BAG3 promoted cell proliferation and inhibited apoptosis by activating autophagy though the NF-x03BA;B signaling pathway in hypoxia-injured cardiomyocytes. © 2016 The Author(s) Published by S. Karger AG, Basel.

Flight Bags as a Cause of Back Injuries Among Commercial Pilots.

Science.gov (United States)

Kanumuri, Vamsi S R; Zautke, John L; Dorevitch, Samuel

2015-06-01

Pilots of fixed wing commercial aircraft face numerous occupational hazards. Low back pain is among the most common and costly workplace injury, though relatively little is known about causes of back injuries among pilots. The awkward lifting and twisting maneuvers in the flight deck to position flight bags has not been described as a cause of occupational back injury among pilots. A case series of low back injuries among pilots was identified and described by a retrospective review of charts at an airport-based clinic. Circumstances of occupational back injury, initial direct medical costs, treatment, and work status following evaluation were described. Over a 6-yr period, 37 occupational low back injuries among 35 pilots were evaluated and treated. Of these, 24 (65%) involved flight bags. Only 27% of pilots with flight bag-associated injuries were returned to work after initial evaluation; medications with sedating properties were frequently required for treatment. Injuries due to slips, trips, and falls, typically in jet bridges or associated with hotel shuttles, were common among pilots with back injuries not related to flight bags. The majority of occupational low back injuries seen among pilots in an airport based clinic were attributable to use of flight bags. Substituting electronic flight bags for traditional flight bags could contribute to back injury prevention among pilots.

Vape shops: who uses them and what do they do?

Science.gov (United States)

Pattinson, Julie; Lewis, Sarah; Bains, Manpreet; Britton, John; Langley, Tessa

2018-04-23

'Vape shops' are a popular source for buying electronic cigarettes (e-cigarettes) and related products. The products that vape shops sell, their marketing techniques and the extent to which they provide information or encouragement to smokers to quit tobacco use, as well as the patterns of tobacco and e-cigarette use of their customers are not well understood. We conducted cross-sectional surveys in vape shops in the East Midlands region of the United Kingdom, one with shop staff (n = 41), and one with customers (n = 197). The majority of customers (84%) currently used e-cigarettes. Among current vapers, 19% were dual users and 78% had quit smoking. Over half of vapers reported using a lower level of nicotine in their current e-liquid than when they started using e-cigarettes. There was a wide variety in products and price ranges between the shops. Many staff reported that customers ask for information about quitting smoking (90%). Less than half reported providing smoking cessation advice, although 76% of staff reported feeling confident about delivering cessation advice to customers who ask for it. Just under half of customers and shop staff said they thought it was appropriate to deliver formal in-store smoking cessation support. The majority of vape shop customers are vapers who have quit smoking. Shop staff play a central role in providing customers with product information, and many provide smoking cessation advice. Further research is needed to investigate the potential for smoking cessation interventions in vape shops, including the extent to which these would appeal to non-vapers.

A validation study of new cryopreservation bags for implementation in a blood and marrow transplant laboratory.

Science.gov (United States)

Pomper, Gregory J; Wilson, Emily; Isom, Scott; Hurd, David D

2011-06-01

A new cryopreservation bag for hematopoietic cell transplantation requires validation as a safe alternative to the bag currently being used in the laboratory. The new bag was validated using both laboratory and clinical criteria. Laboratory validation proceeded using paired samples of mononuclear cells processed using standard procedures. Cells cryopreserved in the new and old bags were compared for viability, cell counts, CD34 enumeration, colony-forming unit assays, and bag integrity. After completion of laboratory investigations, engraftment with the new bags was followed and compared to historical engraftment using the old bags. There were no significant differences between the old and new bags detected using laboratory studies. Bag integrity was equivalent. The validation data suggested impaired cell function after cryopreservation in the new bags, but there were no significant differences in engraftment potential using either material. Days to engraftment was longer using the new bags, but statistical analysis revealed an association with CD34 dose and not with cryopreservation bag type. The new bags were noninferior to the old bags. A change in cryopreservation bag type may appear to affect cell function and potentially affect engraftment. Multiple analyses may be needed to understand the effect of cell processing changes. © 2010 American Association of Blood Banks.

A hybrid job-shop scheduling system

Science.gov (United States)

Hellingrath, Bernd; Robbach, Peter; Bayat-Sarmadi, Fahid; Marx, Andreas

1992-01-01

The intention of the scheduling system developed at the Fraunhofer-Institute for Material Flow and Logistics is the support of a scheduler working in a job-shop. Due to the existing requirements for a job-shop scheduling system the usage of flexible knowledge representation and processing techniques is necessary. Within this system the attempt was made to combine the advantages of symbolic AI-techniques with those of neural networks.

A multipurpose shopping trip model to assess retail agglomeration effects

NARCIS (Netherlands)

Arentze, T.A.; Oppewal, H.; Timmermans, H.J.P.

2005-01-01

Multipurpose shopping is a prominent and relevant feature of shopping behavior. However, no methodology is available to assess empirically how the demand for multipurpose shopping depends on retail agglomeration or, in general, the characteristics of retail supply, such as the numbers and types of

Outpatient-shopping behavior and survival rates in newly diagnosed cancer patients.

Science.gov (United States)

Chiou, Shang-Jyh; Wang, Shiow-Ing; Liu, Chien-Hsiang; Yaung, Chih-Liang

2012-09-01

To evaluate the appropriateness of the definition of outpatient-shopping behavior in Taiwanese patients. Linked study of 3 databases (Taiwan Cancer Registry, National Health Insurance [NHI] claim database, and death registry database). Outpatient shopping behavior was defined as making at least 4 or 5 physician visits to confirm a cancer diagnosis. We analyzed patient-related factors and the 5-year overall survival rate of the outpatient-shopping group compared with a nonshopping group. Using the household registration database and NHI database, we determined the proportion of outpatient shopping, characteristics of patients who did and did not shop for outpatient therapy, time between diagnosis and start of regular treatment, and medical service utilization in the shopping versus the nonshopping group. Patients with higher incomes were significantly more likely to shop for outpatient care. Patients with higher comorbidity scores were 1.4 times more likely to shop for outpatient care than patients with lower scores. Patients diagnosed with more advanced cancer were more likely to shop than those who were not. Patients might be more trusting of cancer diagnoses given at higher-level hospitals. The nonshopping groups had a longer duration of survival over 5 years. Health authorities should consider charging additional fees after a specific outpatient- shopping threshold is reached to reduce this behavior. The government may need to reassess the function of the medical sources network by shrinking it from the original 4 levels to 2 levels, or by enhancing the referral function among different hospital levels.

An update on purple urine bag syndrome

Directory of Open Access Journals (Sweden)

Hadano Y

2012-08-01

Full Text Available Yoshiro Hadano,1 Taro Shimizu,2 Shimon Takada,3 Toshiya Inoue,4 Sumire Sorano51Department of General Internal Medicine and Infectious Diseases, Rakuwakai Otowa Hospital, Yamashina-ku, Kyoto, Japan; 2Rollins School of Public Health, Emory University, Atlanta, GA, USA; 3Department of General Internal Medicine, Osaka City General Hospital, Miyakojima-ku, Osaka, Japan; 4Department of Emergency Medicine, Urasoe General Hospital, Urasoe-city, Okinawa, Japan; 5Kobe University School of Medicine, Kusunokicho, Chuoku, Kobe, JapanAbstract: Purple urine bag syndrome is characterized by the urinary drainage bag turning purple in patients on prolonged urinary catheterization, especially those in the bedridden state. It is associated with bacterial urinary tract infections caused by indigo-producing and indirubin-producing bacteria, usually affects women, and is associated with alkaline urine, constipation, and a high bacterial load in the urine. Almost all patients with purple urine bag syndrome are catheterized due to significant disability, and the urinary pH is 7.0 or more. In general, intensive treatment with antibiotics is not recommended. Purple urine bag syndrome per se almost always appears to be asymptomatic and harmless. However, caution is needed, because some cases have been reported to show progression to severe disease states, so further research into the morbidity and mortality of this infection is warranted.Keywords: purple urine, urinary catheterization, geriatrics, urinary tract infection

Technicians and Shop Owners

Science.gov (United States)

Overview page provides information for shops and technicians that repair or service motor vehicle air-conditioning systems, including information on proper training, approved equipment, and regulatory practices.

Development and functional significance of dorsal air bags in ...

African Journals Online (AJOL)

Histological examination of the air bags showed that they were integumentary structures composed of an outer epidermis and an inner dermis. The air bags were not connected to the respiratory system. The body temperature (Tb) of Monteiro's Hornbill nestlings increased significantly with increasing age. Comparisons of ...

Developing Baby Bag Design by Using Kansei Engineering Method

Science.gov (United States)

Janari, D.; Rakhmawati, A.

2016-01-01

Consumer's preferences and market demand are essential factors for product's success. Thus, in achieving its success, a product should have design that could fulfill consumer's expectation. Purpose of this research is accomplishing baby bag product as stipulated by Kansei. The results that represent Kanseiwords are; neat, unique, comfortable, safe, modern, gentle, elegant, antique, attractive, simple, spacious, creative, colorful, durable, stylish, smooth and strong. Identification value on significance of correlation for durable attribute is 0,000 baby's bag. While the value of coefficient regression is 0,812 baby's bag.The result of the baby's bag final design selectionbased on the questionnaire 3 is resulting the combination of all design. Space for clothes, diaper's space, shoulder grip, side grip, bottle's heater pocket and bottle's pocket are derived from design 1. Top grip, space for clothes, shoulder grip, and side grip are derived from design 2.Others design that were taken are, spaces for clothes from design 3, diaper's space and clothes’ space from design 4.

Online Infrastructure in Supply Chain for Hardware Shops

OpenAIRE

Sørensen , Karl ,

2014-01-01

Part 4: Private Services; International audience; This article describes how the Scandinavian network communication system DATEX was used to build an online infrastructure in a retail chain of privately owned hardware shops and Do-It-Yourself (DIY) centers. The solution gave the staff in the shops the possibility to use EDP as early as in 1983. The Internet did not exist at the time. EDP was not part of the daily work in the shop and was for most employees something unknown that took place at...

Possible Opioid Shopping and its Correlates.

Science.gov (United States)

Walker, Alexander M; Weatherby, Lisa B; Cepeda, M Soledad; Bradford, Daniel; Yuan, Yingli

2017-11-01

We created an operational definition of possible opioid shopping in US commercial health insurance data and examined its correlates. The population consisted of 264,204 treatment courses in persons with a fill for an opioid or diuretic prescription in 2012 and a second within 18 months. We examined counts of prescribers and pharmacies and the numbers of fills and overlaps for ability to discriminate courses of opioids from diuretics, which were a negative control. The most discriminatory measure, indicating possible shopping behavior, was cross-tabulated against other prescriptions filled and diagnoses as found in insurance claims. The associations between claims characteristics and shopping behavior were assessed in a logistic regression. A definition that classified possible "moderate" or "extensive" shopping when a person obtained drug through at least 3 practices and at least 3 pharmacies over 18 months was highly discriminatory between opioid and diuretic treatment. Overlaps between fills and number of fills did not improve the discrimination. Data from insurance claims strongly predicted moderate-to-extensive levels of possible shopping (c=0.82). Prominent among 20 significant predictors were: state of residence; amount of opioid dispensed; self-payment; use of nonspecialist prescribers; high use of anxiolytics, hypnotics, psychostimulants, and antipsychotics; and use of both immediate release and extended-release or long-acting opioids. The use of ≥3 prescribing practices and ≥3 dispensing pharmacies over 18 months sharply discriminated courses of opioid treatment from courses of diuretics. This pattern of fills was additionally associated with the numbers of nonspecialist and self-paid fills, the total morphine milligram equivalents dispensed, and heavier use of drugs for anxiety, sleep, attention, and psychosis.

Census tract correlates of vape shop locations in New Jersey.

Science.gov (United States)

Giovenco, Daniel P; Duncan, Dustin T; Coups, Elliot J; Lewis, M Jane; Delnevo, Cristine D

2016-07-01

Vape shops are opening across the USA, but little is known about the types of neighborhoods where they are located. This study explores community-level predictors of vape shop locations in New Jersey, USA. Vape shops were identified in July 2015 using a validated systematic online search protocol and geocoded using Google Earth Pro. Multivariable logistic regression identified demographic and other predictors of vape shop presence at the census tract level. Tobacco outlet density was consistently associated with higher odds of vape shop presence after adjusting for covariates (pretail were negatively associated with vapor outlets. Census tracts with a higher proportion of non-Hispanic black residents had significantly lower odds of having a vape shop (β=-0.03, pretail is high, but where fewer racial minorities live. The retail environment may communicate social norms regarding vaping and ultimately influence use behaviors of community residents. Copyright © 2016 Elsevier Ltd. All rights reserved.

Energy benchmarking for shopping centers in Gulf Coast region

International Nuclear Information System (INIS)

Juaidi, Adel; AlFaris, Fadi; Montoya, Francisco G.; Manzano-Agugliaro, Francisco

2016-01-01

Building sector consumes a significant amount of energy worldwide (up to 40% of the total global energy); moreover, by the year 2030 the consumption is expected to increase by 50%. One of the reasons is that the performance of buildings and its components degrade over the years. In recent years, energy benchmarking for government office buildings, large scale public buildings and large commercial buildings is one of the key energy saving projects for promoting the development of building energy efficiency and sustainable energy savings in Gulf Cooperation Council (GCC) countries. Benchmarking would increase the purchase of energy efficient equipment, reducing energy bills, CO_2 emissions and conventional air pollution. This paper focuses on energy benchmarking for shopping centers in Gulf Coast Region. In addition, this paper will analyze a sample of shopping centers data in Gulf Coast Region (Dubai, Ajman, Sharjah, Oman and Bahrain). It aims to develop a benchmark for these shopping centers by highlighting the status of energy consumption performance. This research will support the sustainability movement in Gulf area through classifying the shopping centers into: Poor, Usual and Best Practices in terms of energy efficiency. According to the benchmarking analysis in this paper, the shopping centers best energy management practices in the Gulf Coast Region are the buildings that consume less than 810 kW h/m"2/yr, whereas the poor building practices are the centers that consume greater than 1439 kW h/m"2/yr. The conclusions of this work can be used as a reference for shopping centres benchmarking with similar climate. - Highlights: •The energy consumption data of shopping centers in Gulf Coast Region were gathered. •A benchmarking of energy consumption for the public areas for the shopping centers in the Gulf Coast Region was developed. •The shopping centers have the usual practice in the region between 810 kW h/m"2/yr and 1439 kW h/m"2/yr.

Solitons, monopoles and bags

International Nuclear Information System (INIS)

Rajasekaran, G.

1978-01-01

Recent developments in the theory of solitons and related objects in the fields of high energy physics and nuclear physics are reviewed. The aim is to concentrate on the physical aspects and explain why these objects have awakened the interest of physicists. The physics of solitons is discussed with the help of a simple one-dimensional soliton. Then the physically more interesting monopole-soliton is considered and its connection with the original Dirac monopole is pointed out. The ''revolutionary'' possibility of making fermions as composites of bosons is indicated. Both the one-dimensional solitons and the monopole-soliton are examples of ''topological solitons'' and the role of topology in the physics of solitons is explained. The possible importance of topological quantum numbers in providing a fundamental understanding of the basic conservation laws of physics is pointed out. Two examples of non-topological solitons namely, the nucleon as a bag of almost-massless quarks and the abnormal nucleons as a bag of almost massless nucleons is discussed. (auth.)

A causal model to evaluate the influence of consumer's perceptions of online shopping on their shopping behavior

OpenAIRE

Asakawa, Masami; Okano, Masao

2009-01-01

This study examined the factors influencing consumers' perception of online shopping and developed a causal model that explains how this perception affects their online-shopping behavior. We administered a questionnaire survey to 297 college students. By utilizing the answers to 13 questions pertaining to consumer perceptions, we conducted a factor analysis that identified the following three factors: "convenience", "anxiety regarding security" and "poor navigation". On the basis of this resu...

Getting closer to people: family planning provision by drug shops in Uganda

Science.gov (United States)

Akol, Angela; Chin-Quee, Dawn; Wamala-Mucheri, Patricia; Namwebya, Jane Harriet; Mercer, Sarah Jilani; Stanback, John

2014-01-01

ABSTRACT Background: Private-sector drug shops are often the first point of health care in sub-Saharan Africa. Training and supporting drug shop and pharmacy staff to provide a wide range of contraceptive methods and information is a promising high-impact practice for which more information is needed to fully document implementation experience and impact. Methods: Between September 2010 and March 2011, we trained 139 drug shop operators (DSOs) in 4 districts of Uganda to safely administer intramuscular DMPA (depot medroxyprogesterone acetate) contraceptive injections. In 2012, we approached 54 of these DSOs and interviewed a convenience sample of 585 of their family planning clients to assess clients' contraceptive use and perspectives on the quality of care and satisfaction with services. Finally, we compared service statistics from April to June 2011 from drug shops, community health workers (CHWs), and government clinics in 3 districts to determine the drug shop market share of family planning services. Results: Most drug shop family planning clients interviewed were women with low socioeconomic status. The large majority (89%) were continuing family planning users. DMPA was the preferred contraceptive. Almost half of the drug shop clients had switched from other providers, primarily from government health clinics, mostly as a result of more convenient locations, shorter waiting times, and fewer stock-outs in drug shops. All clients reported that the DSOs treated them respectfully, and 93% trusted the drug shop operator to maintain privacy. Three-quarters felt that drug shops offered affordable family planning services. Most of the DMPA clients (74%) were very satisfied with receiving their method from the drug shop and 98% intended to get the next injection from the drug shop. Between April and June 2011, clinics, CHWs, and drug shops in 3 districts delivered equivalent proportions of couple-years of protection, with drug shops leading marginally at 36

Self-control predicts attentional bias assessed by online shopping-related Stroop in high online shopping addiction tendency college students.

Science.gov (United States)

Jiang, Zhaocai; Zhao, Xiuxin; Li, Cancan

2017-05-01

The aim of this study was to examine the relationships of personality types (i.e., self-control, BAS/BIS) and online shopping addiction (OSA) behavior and to investigate whether high-OSA tendency individuals display attentional biases toward online shopping-related (OS-related) stimuli as well as the links between attentional bias and personality types. The study included 98 college students divided into three groups (i.e., high-, medium- and low-OSA) according to their OSA behavior. The personality types (i.e., self-control, BAS/BIS) and OSA behavior were investigated by questionnaires. The attentional bias was evaluated by the OS-related Stroop and dot-probe task (DPT) paradigms. OSA was positively predicted by time spent on online shopping per day and average consumption for online shopping monthly, and negatively by self-control. High-OSA individuals displayed significant attentional biases toward OS-related stimuli in the Stroop, but not DPT paradigm. Moreover, the attentional bias toward OSA-related stimuli in high-OSA individuals was negatively correlated with self-control. These findings demonstrated the critical role of self-control in OSA behavior and attentional bias to OS-related stimuli in high-OSA individuals, indicating that more importance should be attached to self-control for the clinical intervention of online shopping addiction in future studies. Copyright © 2017 Elsevier Inc. All rights reserved.

Vacuum-bag-only processing of composites

Science.gov (United States)

Thomas, Shad

Ultrasonic imaging in the C-scan mode in conjunction with the amplitude of the reflected signal was used to measure flow rates of an epoxy resin film penetrating through the thickness of single layers of woven carbon fabric. Assemblies, comprised of a single layer of fabric and film, were vacuum-bagged and ultrasonically scanned in a water tank during impregnation at 50°C, 60°C, 70°C, and 80°C. Measured flow rates were plotted versus inverse viscosity to determine the permeability in the thin film, non-saturated system. The results demonstrated that ultrasonic imaging in the C-scan mode is an effective method of measuring z-direction resin flow through a single layer of fabric. The permeability values determined in this work were consistent with permeability values reported in the literature. Capillary flow was not observed at the temperatures and times required for pressurized flow to occur. The flow rate at 65°C was predicted from the linear plot of flow rate versus inverse viscosity. The effects of fabric architecture on through-thickness flow rates during impregnation of an epoxy resin film were measured by ultrasonic imaging. Multilayered laminates comprised of woven carbon fabrics and epoxy films (prepregs) were fabricated by vacuum-bagging. Ultrasonic imaging was performed in a heated water tank (65°C) during impregnation. Impregnation rates showed a strong dependence on fabric architecture, despite similar areal densities. Impregnation rates are directly affected by inter-tow spacing and tow nesting, which depend on fabric architecture, and are indirectly affected by areal densities. A new method of predicting resin infusion rates in prepreg and resin film infusion processes was proposed. The Stokes equation was used to derive an equation to predict the impregnation rate of laminates as a function of fabric architecture. Flow rate data previously measured by ultrasound was analyzed with the new equation and the Kozeny-Carman equation. A fiber

Methods in Mapping Usability of Malaysia’s Shopping Centre

Directory of Open Access Journals (Sweden)

Abdul Ghani Aida Affina

2016-01-01

Full Text Available With more than 200 number of shopping centre in Klang Valley itself, we the consumer actually have vast of choices. Instead of the machineries varieties from the lower class product till the posh one, each of those shopping centres eventually offers the typical product same as others. Those shopping centers are competing with each other and in great endeavour to attract more consumers, to visit and spend. As for the visitor, the typical product and boring ambience seems similar in all malls, and is looking something beyond the standard. Something that promising quality embedded in shopping centre which evokes the various emotions of the user along their journey in malls. This quality is known as usability. Usability; as defined generally is a global user’s experience response with product, environment, service or facilities. It is an assessment in extracting the qualities of shopping centre design. In mapping it, there are a few synthesizing methods to implement it. Therefore, this paper purposely to review the method that been used in usability of Malaysia’s shopping centre research with a few references on previous research done in usability assessment by predecessor’s scholars. With the accentuation on three elements that anchoring what the usability is: effectiveness, efficient and satisfaction, it is hope that this overview can lead other researcher in portraying its relationship with the quality and ‘user friendly’ design of shopping centre.

Investigating Comfort Temperatures and Heat Transfer in Sleeping Bags

Science.gov (United States)

Hill, Trevor; Hill, Lara

2017-01-01

After many years of confusion, thermal performance of sleeping bags has now been quantified and unified using expensive test techniques. Based on Newton's law of cooling, we present a simple inexpensive test and model to check manufacturers' claims on the temperature performance of a range of modern sleeping bags.

INVESTIGATING THE COLLECTIVE ONLINE purchase PHENOMENON: FACTORS AFFECTING THE SHOPPING INTENSITY

Directory of Open Access Journals (Sweden)

Everton Roberto Comin

2014-04-01

Full Text Available The collective online shopping is a recent phenomenon in Brazil whose objective is to sell products and services for a minimum number of consumers. This study aims to investigate whether the intensity of collective online shopping is influenced by the aspects consumer interest in online collective shopping, impulse buying and insecurity. The data collection was based on a questionnaire with closed questions with multiple choices and a 5-point Likert scale.The final sample is composed of 143 respondents. Data was analyzed through the following statistic techniques: exploratory data analysis, exploratory factor analysis, reliability analysis, and logistic regression. The results suggest that people more interest in collective shopping are more likely to make collective shopping. People who feel greater insecurity in navigating the website is less likely to make collective shopping. It was observed that there is no a positive relationship between impulse shopping and collective purchasing. Some limitations include the number of constructs and sample characteristics.

Baby boomers' food shopping habits. Relationships with demographics and personal values.

Science.gov (United States)

Worsley, Anthony; Wang, Wei C; Hunter, Wendy

2010-12-01

The purpose of this study was to examine baby boomers' food shopping behaviours and to investigate their relationships with demographics and personal values. A questionnaire concerning food shopping behaviours, personal values and demographics was mailed to a random sample of 2975 people aged 40-70 years in Victoria, Australia. Usable questionnaires of 1031 were obtained. Structural equation modelling was employed for data analyses. The analyses revealed that demographics and personal values influenced shopping behaviours via different pathways among male and female baby boomers. For example, self-direction positively impacted on shopping planning for men but negatively influenced price minimization for women. Among women only, age was positively related to shopping planning and negatively to price minimization. Thus, both personal values and demographics influenced baby boomers' shopping behaviours. Since values are more likely to be amenable to change than demographics, segmentation of the population via value orientations would facilitate targeted interventions to promote healthy food shopping. Copyright © 2010 Elsevier Ltd. All rights reserved.

The role of food shopping in later life.

Science.gov (United States)

Pettigrew, Simone; Worrall, Caitlin; Biagioni, Nicole; Talati, Zenobia; Jongenelis, Michelle

2017-04-01

By the time they reach retirement, individuals are typically highly experienced in sourcing food products and they have strong familiarity with food retailing environments. To investigate the ongoing role of food shopping in later life, the present study explored seniors' attitudes to food shopping and their food-selection behaviours through the lens of their broader lifestyles. The aim was to provide insights of relevance to the development of future efforts to optimise seniors' food shopping experiences and nutrition-related outcomes. Interviews were conducted with 75 Western Australians aged 60 + years to discuss food shopping in the context of their day-to-day lives. The sample was comprised mainly of women (n = 64) and the average age was 74 years. In general, food shopping was perceived to be a manageable but mundane part of life. The findings suggest that there has been an improvement in food retailing practices because many of the numerous areas of concern identified in previous research conducted in this geographical location a decade ago were not nominated as relevant by the interviewees. Instead, food-related issues reported to be most problematic included the difficulties associated with sourcing affordable food products that had been produced locally and that did not contain unacceptable food additives. Seniors' food shopping concerns thus appear to have changed from functional aspects of the physical store environment to product attributes that reflect the increasing industrialisation of the food industry. Copyright © 2016 Elsevier Ltd. All rights reserved.

Meat Safety: An Evaluation of Portuguese Butcher Shops.

Science.gov (United States)

Santos, Ana; Cardoso, Margarida Fonseca; Costa, José M Correia da; Gomes-Neves, Eduarda

2017-07-01

Butcher shops are end points in the meat chain, and they can have a determinant role in cross-contamination control. This study aims to determine whether Portuguese butcher shops comply with European and Portuguese law regarding the sale of fresh meat and meat products. Butcher shops (n = 73) were assessed for meat handler and facility hygiene and for maintenance of the premises. Handlers (n = 88) were given a questionnaire composed of questions about knowledge and practice, including hazard analysis and critical control point (HACCP) and good practice in food industry, to assess their knowledge of and compliance with food safety practices. A checklist of 27 items was used to evaluate facility and meat handler hygiene and butcher shop maintenance. Our results revealed some lack of compliance in all the areas evaluated. The mean knowledge and practice score among the operators was 68.0%, and the mean "visual inspection" score for the butcher shops was 64.0%. Severe deficiencies were observed in the mandatory implementation of HACCP principles in this type of small food business. These findings indicate a need to modify training to enhance compliance with European food safety regulations at this step of the meat chain.

Flow shop scheduling with heterogeneous workers

OpenAIRE

Benavides, Alexander J.; Ritt, Marcus; Miralles Insa, Cristóbal Javier

2014-01-01

We propose an extension to the flow shop scheduling problem named Heterogeneous Flow Shop Scheduling Problem (Het-FSSP), where two simultaneous issues have to be resolved: finding the best worker assignment to the workstations, and solving the corresponding scheduling problem. This problem is motivated by Sheltered Work centers for Disabled, whose main objective is the labor integration of persons with disabilities, an important aim not only for these centers but for any company d...

Commercial liquid bags as a potential source of venous air embolism in shoulder arthroscopy.

Science.gov (United States)

Austin, Luke; Zmistowski, Benjamin; Tucker, Bradford; Hetrick, Robin; Curry, Patrick; Williams, Gerald

2010-09-01

Venous air embolism is a rare but potentially fatal complication of arthroscopy. Fatal venous air embolism has been reported with as little as 100 mL of air entering the venous system. During liquid-only arthroscopy, avenues for air introduction into the joint are limited. Therefore, we hypothesized that commercially prepared 3-L saline-solution bags are a source of potentially fatal amounts of gas that can be introduced into the joint by arthroscopic pumps. Eight 3-L arthroscopic saline-solution bags were obtained and visually inspected for air. The air was aspirated from four bags, and the volume of the air was recorded. A closed-system pump was prepared, and two 3-L bags were connected to it. The pump emptied into an inverted graduated cylinder immersed in a water bath. Both bags were allowed to run dry. Two more bags were then connected and also allowed to run dry. The air was quantified by the downward displacement of water. The experiment was then repeated with the four bags after the air had been aspirated from them. This experiment was performed at three institutions, with utilization of three pump systems and two brands of 3-L saline-solution bags. Air was visualized in all bags, and the bags contained between 34 and 85 mL of air. Arthroscopic pumps can pump air efficiently through the tubing. The total volumes of gas ejected from the tubing after the four 3-L bags had been emptied were 75, 80, and 235 mL. When bags from which the air had been evacuated were used, no air exited the system. Because a saline-solution arthroscopic pump is theoretically a closed system, venous air embolism has not been a concern. However, this study shows that it is possible to pump a fatal amount of air from 3-L saline-solution bags into an environment susceptible to the creation of emboli. Evacuation of air from the 3-L bags prior to use may eliminate this risk.

SHOP: scaffold hopping by GRID-based similarity searches

DEFF Research Database (Denmark)

Bergmann, Rikke; Linusson, Anna; Zamora, Ismael

2007-01-01

A new GRID-based method for scaffold hopping (SHOP) is presented. In a fully automatic manner, scaffolds were identified in a database based on three types of 3D-descriptors. SHOP's ability to recover scaffolds was assessed and validated by searching a database spiked with fragments of known...... scaffolds were in the 31 top-ranked scaffolds. SHOP also identified new scaffolds with substantially different chemotypes from the queries. Docking analysis indicated that the new scaffolds would have similar binding modes to those of the respective query scaffolds observed in X-ray structures...

ESDに向けての14C測定の利用

OpenAIRE

中村, 俊夫; 太田, 友子; 西田, 真砂美; Nakamura, Toshio; Ohta, Tomoko; Nishida, Masami

2015-01-01

We have measured 14C concentration of plastic bag samples to confirm that the plastic bags were produced from sustainable carbon, carbon contained in living plants, instead of fossil carbon. Three plastic bags used for normal shopping of food carrier had descriptions on the bag that they were produced from sustainable carbon in some amount. To check the amount of carbon from recent plant remains, we have measured 14C concentrations of the plastic bag samples. The 14C contents were consistent ...

The Cheshire Cat principle applied to hybrid bag models

International Nuclear Information System (INIS)

Nielsen, H.B.; Wirzba, A.

1987-05-01

Here is argued for the Cheshire Cat point of view according to which the bag (itself) has only notational, but no physical significance. It is explained in a 1+1 dimensional exact Cheshire Cat model how a fermion can escape from the bag by means of an anomaly. We also suggest that suitably constructed hybrid bag models may be used to fix such parameters of effective Lagrangians that can otherwise be obtained from experiments only. This idea is illustrated in a calculation of the mass of the pseudoscalar η' meson in 1+1 dimension. Thus there is hope to find a construction principle for a phenomenologically sensible model. (orig.)

Optimal experience in online shopping: the influence of flow

OpenAIRE

Sharkey, Ultan; Acton, Thomas; Conboy, Kieran

2012-01-01

peer-reviewed This research investigates the influences of product presentation modes, decision behaviour and the consumer experience on Internet shopping. The growth of online shopping brings with it cognitive challenges for consumers attempting to assess large numbers of options in purchase decisions. Further, there is little guidance for vendors in terms of presenting large numbers of product. In this study, online shopping is viewed as an information processing, decision ta...

Home-School Literacy Bags for Twenty-First Century Preschoolers

Science.gov (United States)

Brand, Susan Trostle; Marchand, Jessica; Lilly, Elizabeth; Child, Martha

2014-01-01

Combining home-school literacy bags with preschool family literature circles provided a strong foundation for family involvement at home and school during this year-long Reading Partners project, and helped parents become essential partners in their children's literacy development. Using home-school literacy bags, children and parents learned…

Bogota bag in the treatment of abdominal wound dehiscence.

Science.gov (United States)

Sukumar, N; Shaharin, S; Razman, J; Jasmi, A Y

2004-06-01

A patient who underwent emergency laparotomy for rectal prolapse developed repeated abdominal wound dehiscence and subsequently an enteric fistula. The management of abdominal wound dehiscence is discussed, specifically with regards to the Bogota bag. Use of Bogota bag has been reported worldwide but this may be the first report here.

Are the N and Δ deformed MIT bags

International Nuclear Information System (INIS)

Clement, G.; Maamache, M.

1985-01-01

The influence of the one-gluon exchange interaction, zero-point energy, and centre-of-mass correction, on the deformation of the nucleon and Δ bags, is studied in the MIT bag model. If the sharp MIT boundary conditions are taken seriously, the strong dependence of the zero-point energy on the deformation leads to the collapse of the N and Δ bags for realistic values of the strong fine structure constant α/sub S/. If on the other hand the zero-point energy is ignored altogether, then the nucleon, spherical for α/sub S/ 3.25, while the Δ is always prolate. The various predictions of the model are, for α/sub S/> or approx. =3.25, consistent with experiment, except for the proton magnetic moment which is only about 40% of the experimental value

Anterior haptic flexing and in-the-bag subluxation of an accommodating intraocular lens due to excessive capsular bag contraction.

Science.gov (United States)

Kramer, Gregory D; Werner, Liliana; Neuhann, Tobias; Tetz, Manfred; Mamalis, Nick

2015-09-01

We describe the case of a patient who had cataract surgery with implantation of the hydrophilic acrylic Tetraflex accommodating intraocular lens (IOL), with subsequent development of capsulorhexis phimosis and in-the-bag IOL subluxation. Contraction of the capsular bag secondary to fibrosis resulted in significant anterior flexing of the lens haptic component. Explantation of the IOL-capsular bag complex was required 7 years after implantation. Histopathologic analysis demonstrated multiple areas of thick anterior subcapsular fibrosis. Pseudoexfoliative material was present throughout the surface of the lens capsule. Intraocular lenses manufactured from hydrophilic acrylic material are highly flexible and may be more susceptible to capsule contraction, even in the absence of predisposing ocular and systemic conditions. This case highlights the importance of developing guidelines regarding patient screening and selection for the appropriate use of accommodating and other highly flexible IOLs. No author has a financial or proprietary interest in any material or method mentioned. Copyright © 2015 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

Performance of triple bagging hermetic technology for postharvest storage of cowpea grain in Niger

KAUST Repository

Baoua, Ibrahim B.; Margam, Venu; Amadou, Laouali; Murdock, Larry L.

2012-01-01

) new 100 kg bags and (3) once-used 50 kg bags, all filled with naturally infested untreated cowpeas. In these PICS bags the O 2 levels within the bags initially fell to about 3 percent (v/v) while the CO 2 rose to nearly 5 percent (v/v). After five

The Danish game bag record and its role in wildlife management

DEFF Research Database (Denmark)

Asferg, Tommy

2015-01-01

The Danish Game Bag Record and its role in wildlife management The Danish Game Bag Record, i.e. the national hunting statistics database, was initiated in 1941. It is a compilation of annual, mandatory reports on bagged game (shot or trapped) from all hunting licence holders. Today, this database...... is reflected in the methods of collecting the hunting statistics but the basic principle of every hunter reporting his/hers personal game bag every year still applies. From 1941 onwards annual reports were delivered on paper forms, and since year 2000 it has been possible to report electronically via...... management is its ability to reflect changes in population size – at least for some game species – mainly on a nationwide scale, but for some of the more abundant species also on a regional scale. A few examples will be shown to illustrate this. Finally, a few suggestions for improvement of the bag record...

A role of BAG3 in regulating SNCA/α-synuclein clearance via selective macroautophagy.

Science.gov (United States)

Cao, Yu-Lan; Yang, Ya-Ping; Mao, Cheng-Jie; Zhang, Xiao-Qi; Wang, Chen-Tao; Yang, Jing; Lv, Dong-Jun; Wang, Fen; Hu, Li-Fang; Liu, Chun-Feng

2017-12-01

Many studies reveal that BAG3 plays a critical role in the regulation of protein degradation via macroautophagy. However, it remains unknown whether BAG3 affects the quality control of α-synuclein (SNCA), a Parkinson's disease-related protein. In this study, we demonstrated the increases of BAG3 expression in the ventral midbrain of SNCA A53T transgenic mice and also in MG132-treated PC12 cells overexpressing wild-type SNCA (SNCA WT -PC12). Moreover, we showed that BAG3 overexpression was sufficient to enhance the autophagy activity while knockdown of Bag3 reduced it in SNCA WT -PC12 cells. Immunoprecipitation revealed that BAG3 interacted with heat shock protein 70 and sequestosome 1. The immunostaining also showed the perinuclear accumulation and colocalization of BAG3 with these 2 proteins, as well as with LC3 dots in tyrosine hydroxylase-positive neurons in the midbrain of SNCA A53T mice. BAG3 overexpression was able to modulate SNCA degradation via macroautophagy which was prevented by Atg5 knockdown. Taken together, these results indicate that BAG3 plays a relevant role in regulating SNCA clearance via macroautophagy, and the heat shock protein 70-BAG3-sequestosome 1 complex may be involved in this process. Copyright © 2017 Elsevier Inc. All rights reserved.

BAG3 protects bovine papillomavirus type 1-transformed equine fibroblasts against pro-death signals.

Science.gov (United States)

Cotugno, Roberta; Gallotta, Dario; d'Avenia, Morena; Corteggio, Annunziata; Altamura, Gennaro; Roperto, Franco; Belisario, Maria Antonietta; Borzacchiello, Giuseppe

2013-07-22

In human cancer cells, BAG3 protein is known to sustain cell survival. Here, for the first time, we demonstrate the expression of BAG3 protein both in equine sarcoids in vivo and in EqS04b cells, a sarcoid-derived fully transformed cell line harbouring bovine papilloma virus (BPV)-1 genome. Evidence of a possible involvement of BAG3 in equine sarcoid carcinogenesis was obtained by immunohistochemistry analysis of tumour samples. We found that most tumour samples stained positive for BAG3, even though to a different grade, while normal dermal fibroblasts from healthy horses displayed very weak staining pattern for BAG3 expression. By siRNA technology, we demonstrate in EqS04b the role of BAG3 in counteracting basal as well as chemical-triggered pro-death signals. BAG3 down-modulation was indeed shown to promote cell death and cell cycle arrest in G0/G1. In addition, we found that BAG3 silencing sensitized EqS04b cells to phenethylisothiocyanate (PEITC), a promising cancer chemopreventive/chemotherapeutic agent present in edible cruciferous vegetables. Notably, such a pro-survival role of BAG3 was less marked in E. Derm cells, an equine BPV-negative fibroblast cell line taken as a normal counterpart. Altogether our findings might suggest a mutual cooperation between BAG3 and viral oncoproteins to sustain cell survival.

Digitalization influence on shopping centers strategic management

Directory of Open Access Journals (Sweden)

Ioniţă Irene Mihaela

2017-07-01

Full Text Available Shopping centers are an important aspect of the extremely dynamic life of the 21st century consumer. Nowadays, worldwide, shopping centers represent significant multimillion euro investments, remarking themselves with bold architectures and structures and an individual brand image. Retail markets are currently under transformation by a confluence of new retailing technologies, dramatic shifts in the demographic profile and preferences of more affluent and educated shoppers. Part of the market share in modern retail moved to new forms of selling, which weakened the offer of some traditional retailers, while also creating opportunities for retailers to move and integrate their offerings with new digital tools (via electronic commerce, social commerce and mobile commerce. Meeting customer needs and increasing sales are the primary drivers behind retailers use of information systems and technology (IS/IT. New developments in IS/IT offer new opportunities and challenges for organizations and society. The current paper proposes to analyze the way digital media and information technology (computers and mobile devices influences the virtual and physical shopping experiences, and shopping centers management consequently. The need for communication & sales channels integration, the impact of new information technologies (IT’s, the growing role of social / digital media, the balance between personalization and privacy – all represent challenges retail industry needs to currently adapt to face digitalization. E-commerce is transforming both consumer behavior and retailing business models, by greatly expanding shopping convenience, selection and affordability.

New Digital Marketing Actors: Private Shopping Clubs and Their Advertising Practices

Directory of Open Access Journals (Sweden)

Nazlım Tüzel Uraltaş

2014-12-01

In the first part of the study the concept of digital marketing and its historical background will be explained. In the second part online shopping behavior, online shopping training activities in Turkey and private shopping clubs will be examined.  The last part of the study will deal with the advertising practices of private shopping clubs. The study is essentially a literature review; thus, the resources are mostly secondary in nature.

Bag filters

Energy Technology Data Exchange (ETDEWEB)

Yoshida, M; Komeda, I; Takizaki, K

1982-01-01

Bag filters are widely used throughout the cement industry for recovering raw materials and products and for improving the environment. Their general mechanism, performance and advantages are shown in a classification table, and there are comparisons and explanations. The outer and inner sectional construction of the Shinto ultra-jet collector for pulverized coal is illustrated and there are detailed descriptions of dust cloud prevention, of measures used against possible sources of ignition, of oxygen supply and of other topics. Finally, explanations are given of matters that require careful and comprehensive study when selecting equipment.

Storage quality and marketability potential of bagged silage for ...

African Journals Online (AJOL)

Bagged sole maize and maize–cowpea silages in three bag sizes were assessed at 42 and 282 d post-ensiling for sensory and chemical quality. A survey of dairy farmers on silage use and preferences was conducted in the Chikwaka communal area and Marirangwe small-scale commercial farming area. Only silage ...

Bag-of-steps : Predicting lower-limb fracture rehabilitation length

NARCIS (Netherlands)

Pla, Albert; López, Beatriz; Nogueira, Cristofor; Mordvaniuk, Natalia; Blokhuis, Taco J.; Holtslag, Herman R.

2016-01-01

This paper presents bag-of-steps, a new methodology to predict the rehabilitation length of a patient by monitoring the weight he is bearing in his injured leg and using a predictive model based on the bag-of-words technique. A force sensor is used to monitor and characterize the patient's gait,

LinkShop v.1.0.0

Energy Technology Data Exchange (ETDEWEB)

2017-05-15

LinkShop is a software tool for applying the method of Linkography to the analysis time-sequence data. LinkShop provides command line, web, and application programming interfaces (API) for input and processing of time-sequence data, abstraction models, and ontologies. The software creates graph representations of the abstraction model, ontology, and derived linkograph. Finally, the tool allows the user to perform statistical measurements of the linkograph and refine the ontology through direct manipulation of the linkograph.

A cross-cultural comparison of expatriates’ shopping behavior

NARCIS (Netherlands)

Wijnen, G.J.; Kemperman, A.D.A.M.; Janssen, I.I.

2012-01-01

Explored is how shopping centre attributes can be adapted to culture-related shopping behaviour of expatriates. While awareness of consumer ethnicity and effectiveness of culture-based market segmentation are on-going and relevant topics in retailing, there is only limited information available on

Design of Control System for Flexible Packaging Bags Palletizing Production Line Based on PLC

Science.gov (United States)

Zheng, Huiping; Chen, Lin; Zhao, Xiaoming; Liu, Zhanyang

Flexible packaging bags palletizing production line is to put the bags in the required area according to particular order and size, in order to finish handling, storage, loading and unloading, transportation and other logistics work of goods. Flexible packaging bags palletizing line is composed of turning bags mechanism, shaping mechanism, indexing mechanism, marshalling mechanism, pushing bags mechanism, pressing bags mechanism, laminating mechanism, elevator, tray warehouse, tray conveyor and loaded tray conveyor. Whether the whole production line can smoothly run depends on each of the above equipment and precision control among them. In this paper the technological process and the control logic of flexible packaging bags palletizing production line is introduced. Palletizing process of the production line realized automation by means of a control system based on programmable logic controller (PLC). It has the advantages of simple structure, reliable and easy maintenance etc.

Evidence for the Role of BAG3 in Mitochondrial Quality Control in Cardiomyocytes.

Science.gov (United States)

Tahrir, Farzaneh G; Knezevic, Tijana; Gupta, Manish K; Gordon, Jennifer; Cheung, Joseph Y; Feldman, Arthur M; Khalili, Kamel

2017-04-01

Mitochondrial abnormalities impact the development of myofibrillar myopathies. Therefore, understanding the mechanisms underlying the removal of dysfunctional mitochondria from cells is of great importance toward understanding the molecular events involved in the genesis of cardiomyopathy. Earlier studies have ascribed a role for BAG3 in the development of cardiomyopathy in experimental animals leading to the identification of BAG3 mutations in patients with heart failure which may play a part in the onset of disease development and progression. BAG3 is co-chaperone of heat shock protein 70 (HSP70), which has been shown to modulate apoptosis and autophagy, in several cell models. In this study, we explore the potential role of BAG3 in mitochondrial quality control. We demonstrate that siRNA mediated suppression of BAG3 production in neonatal rat ventricular cardiomyocytes (NRVCs) significantly elevates the level of Parkin, a key component of mitophagy. We found that both BAG3 and Parkin are recruited to depolarized mitochondria and promote mitophagy. Suppression of BAG3 in NRVCs significantly reduces autophagy flux and eliminates clearance of Tom20, an essential import receptor for mitochondria proteins, after induction of mitophagy. These observations suggest that BAG3 is critical for the maintenance of mitochondrial homeostasis under stress conditions, and disruptions in BAG3 expression impact cardiomyocyte function. J. Cell. Physiol. 232: 797-805, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Evaluation of Fresh Food Internet Shopping in Korean Beef

OpenAIRE

金, 鍾和; 森高, 正博; 福田, 晋; Kim, Jong-hwa; Moritaka, Masahiro; Fukuda, Susumu

2013-01-01

This paper focuses on consumer reactions to the fresh food internet shopping on Korea beef. In the paper, we have analyzed an effective relation in consumer's perceived qualities, the evaluation of commodities and the evaluation of fresh food internet shopping. As a result, two effective relations were found. Firstly, consumer's perceived qualities affect the evaluation of commodities. Secondly, the evaluation of commodities affects t-he evaluation of fresh food internet shopping. This result...

Attitudinal Explanation on Virtual Shopping Intention

Directory of Open Access Journals (Sweden)

Ritzky Karina M.R. Brahmana

2014-08-01

Full Text Available Abstract. Virtual stores provide great efficiency in the retail value chain, and their existence has tremendously paved the way for electronic commerce. Understanding the intention of consumers to shop online in attitudinal perspective will provide important contribution to the area of e-commerce. This research proposes Task Technology Fit, Perceived Ease of Use (PEoU, and Perceived Usefulness (PU as the factors that drive consumers’ intention. The results from our survey study of 310 online consumers in Indonesia indicate that TTF affects PEoU and PU significantly. Our hierarchical model also reports that PEoU is the mediating effect on the relationship between TTF and Intention. The resulting model explains a large portion of the factors that lead a user’s behavioural intention to use a virtual shop. Keywords : Attitudinal, Task Technology Fit, Perceived Ease of Use, Perceived Usefulness, Retail, Virtual Shopping Intention

Attractive Casimir effect in an infrared modified gluon bag model

International Nuclear Information System (INIS)

Oxman, L.E.; Amaral, R.L.P.G.; Svaiter, N.F.

2005-01-01

In this work, we are motivated by previous attempts to derive the vacuum contribution to the bag energy in terms of familiar Casimir energy calculations for spherical geometries. A simple infrared modified model is introduced which allows studying the effects of the analytic structure as well as the geometry in a clear manner. In this context, we show that if a class of infrared vanishing effective gluon propagators is considered, then the renormalized vacuum energy for a spherical bag is attractive, as required by the bag model to adjust hadron spectroscopy

Minimizing total weighted completion time in a proportionate flow shop

NARCIS (Netherlands)

Shakhlevich, N.V.; Hoogeveen, J.A.; Pinedo, M.L.

1998-01-01

We study the special case of the m machine flow shop problem in which the processing time of each operation of job j is equal to pj; this variant of the flow shop problem is known as the proportionate flow shop problem. We show that for any number of machines and for any regular performance

Opioid shopping behavior: how often, how soon, which drugs, and what payment method.

Science.gov (United States)

Cepeda, M Soledad; Fife, Daniel; Chow, Wing; Mastrogiovanni, Gregory; Henderson, Scott C

2013-01-01

Doctor shopping (obtaining opioid prescriptions from multiple prescribers) is one example of opioid abuse and diversion. The authors assessed how soon shopping behavior was observed after opioid exposure, number of events per shopper, preferred opioids, and method of payment. This was a cohort study. Individuals with ≤1 dispensing for any opioid in 2008 were followed for 18 months. Shopping behavior was defined as ≤2 prescriptions by different prescribers with ≤1 day of overlap and filled at ≤3 pharmacies. Of 25,161,024 subjects, 0.30% exhibited shopping behavior. Opioid-experienced subjects were 13.7 times more likely to exhibit shopping behavior and had more shopping episodes than opioid-naive subjects. Time to first shopping event was 246.90 ± 163.61 days. Number of episodes was 2.74 ± 4.66. Most subjects with shopping behavior (55.27%) had 1 shopping episode, whereas 9.52% had ≤6 episodes; 88.99% had ≤4 prescribers. Subjects with shopping behavior filled schedule II opioids more often than subjects without shopping behavior (19.51% vs 10.89%) and more often paid in cash (44.85% vs 18.54%). Three of 1000 people exposed to opioids exhibit shopping behavior, on average, 8 months after exposure. Opioid shoppers seek strong opioids, avoid combination products, often pay cash, and obtain prescriptions from few prescribers. © 2012 The Author(s).

21 CFR 178.3730 - Piperonyl butoxide and pyrethrins as components of bags.

Science.gov (United States)

2010-04-01

... bags. 178.3730 Section 178.3730 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... pyrethrins as components of bags. Piperonyl butoxide in combination with pyrethrins may be safely used for insect control on bags that are intended for use in contact with dried feed in compliance with §§ 561.310...

Implementing the Affordable Care Act: State Action to Establish SHOP Marketplaces.

Science.gov (United States)

Dash, Sarah J; Lucia, Kevin W; Thomas, Amy

2014-03-01

The Affordable Care Act seeks to help small employers offer coverage by reforming the small-group market and establishing Small Business Health Options Program (SHOP) marketplaces. Seventeen states and the District of Columbia chose to operate their own SHOP marketplaces in 2014, with the federal government operating the SHOP marketplace in 33 states. This brief examines state decisions to enhance the value of SHOP marketplaces for small employers and finds that most have set predictable participation and eligibility requirements and will offer a competitive choice of insurers and plans. States also are seeking to facilitate small employers' shopping experience through online tools and access to personalized assistance. While not all SHOP marketplaces are yet functioning as intended, their establishment offers an opportunity to identify successful strategies for improving the affordability and accessibility of coverage for small employers.

Cordyceps sinensis attenuates renal fibrosis and suppresses BAG3 induction in obstructed rat kidney.

Science.gov (United States)

Du, Feng; Li, Si; Wang, Tian; Zhang, Hai-Yan; Zong, Zhi-Hong; Du, Zhen-Xian; Li, De-Tian; Wang, Hua-Qin; Liu, Bo; Miao, Jia-Ning; Bian, Xiao-Hui

2015-01-01

BAG3 regulates a number of cellular processes, including cell proliferation, apoptosis, adhesion and migration, and epithelial-mesenchymal transition (EMT). However, the role of BAG3 in renal tubular EMT and renal interstitial fibrosis remains elusive. This study aimed to examine the dynamic expression of BAG3 during renal fibrosis, and to investigate the efficacy of Cordyceps sinensis (C. sinensis) on renal fibrosis. A rat model of unilateral ureteral obstruction (UUO) was established, and the expression of BAG3 and α-SMA, and the efficacy of C. sinensis on renal fibrosis induced by UUO were examined. The results showed that UUO led to collagen accumulation, which was significantly suppressed by C. sinensis. UUO increased the expression of BAG3 and α-SMA, a mesenchymal marker, while UUO induced BAG3 and α-SMA expression was significantly inhibited by C. sinensis. In addition, immunohistochemical staining demonstrated that BAG3 immunoreactivity was restricted to tubular epithelium. In conclusion, BAG3 is a potential target for the prevention and/or treatment of renal fibrosis, and C. Sinensis is a promising agent for renal fibrosis.

Quark compound Bag model for NN scattering up to 1 GeV

International Nuclear Information System (INIS)

Fasano, C.; Lee, T.S.H.

1987-01-01

A Quark Compound Bag model has been constructed to describe NN s-wave scattering up to 1 GeV. The model contains a vertex interaction H/sub D/leftrightarrow/NN/ for describing the excitation of a confined six-quark Bag state, and a meson-exchange interaction obtained from modifying the phenomenological core of the Paris potential. Explicit formalisms and numerical results are presented to reveal the role of the Bag excitation mechanism in determining the relative wave function, P- and S-matrix of NN scattering. We explore the merit as well as the shortcoming of the Quark Compound Bag model developed by the ITEP group. It is shown that the parameters of the vertex interaction H/sub D/leftrightarrow/NN/ can be more rigorously determined from the data if the notation of the Chiral/Cloudy Bag model is used to allow the presence of the background meson-exchange interaction inside Bag excitation region. The application of the model in the study of quark degrees of freedom in nuclei is discussed. 41 refs., 6 figs., 3 tabs

Waste product profile: Plastic film and bags

Energy Technology Data Exchange (ETDEWEB)

Miller, C. [Environmental Industry Associations, Washington, DC (United States)

1996-10-01

Plastic film is recycled by being pelletized following a granulation or densifying process. Manufacturing and converting plants are the major sources of plastic film for recycling because they can supply sufficient amounts of clean raw material of a known resin type. Post-consumer collection programs are more recent. They tend to focus on businesses such as grocery stores that are large generators of plastic bags. In this case, the recycling process is more complex, requiring sorting, washing, and removal of contaminants as a first step. Curbside collection of plastic bags is rare.

Workload control in job shops, grasping the tap

NARCIS (Netherlands)

Land, Martin Jaap

2004-01-01

The term job shops is used to indicate companies that produce customer-specific components in small batches. Jobs (production orders) in a job shop are characterised by a large variety of routings and operation processing times. This variety, combined with irregular order arrivals, generally leads

Ensacamento de frutos de pereira cv. Housui Bagging of nashi pear cv. Housui

Directory of Open Access Journals (Sweden)

Ivan Dagoberto Faoro

2004-04-01

Full Text Available Foi avaliada a qualidade de frutos de pêra japonesa cv. Housui (Pyrus pyrifolia var. culta ensacados com diferentes tipos de sacos de papel e em duas épocas: 34 e 83 dias após a florada. O ensacamento não influenciou na firmeza, no teor de sólidos solúveis totais e no peso médio dos frutos. Sacos vermelhos não induziram aumento do pH da polpa, mas o uso de sacos duplos, sacos marrons, sacos de papel kraft marrons e sacos de pipoca brancos aumentaram significativamente o pH. Ao buscar-se maior precocidade de colheita, os melhores resultados foram obtidos com o uso de sacos pequenos de papel manteiga aos 34 dias após a floração e o uso de sacos grandes duplos ou sacos grandes marrons, 83 dias após a plena floração. O ensacamento 34 dias após a plena floração, com sacos grandes de papel duplo de cor marrom ou sacos de papel kraft marrons, ou ainda o uso de sacos pequenos parafinados transparentes de papel manteiga, aos 34 dias, seguidos pela colocação, aos 83 dias, dos dois tipos de sacos grandes citados anteriormente, resultaram em frutos de melhor qualidade externa (película de coloração homogênea e mais clara, lisa e com lenticelas pouco salientes. O uso de sacos vermelhos de papel manteiga e de sacos de pipoca brancos, com ou sem ensacamento prévio com sacos pequenos de papel manteiga parafinado, não resultaram em melhoria substancial da qualidade externa do fruto.The fruit quality of Nashi pears cv. Housui (Pyrus pyrifolia var. culta have been evaluated after bagging with different paper bags at two bagging dates: 34 and 83 days after full bloom. The bagging did not affect the fruit firmness, the total soluble solids and the average fruit weight. Red bags did not affect the pH of the fruit flesh. However the fruit bagged with double bags of brown color, brown kraft paper and white popcorn paper increased the pH. In order to harvest precociously, the use of small transparent paraffin paper bags 34 days after full bloom

E-Commerce Performance. Shopping Cart Key Performance Indicators

Directory of Open Access Journals (Sweden)

Mihaela I. MUNTEAN

2016-01-01

Full Text Available In an e-commerce performance framework is important to identify the key performance indicators that measure success and together provide the greatest context into the business perfor-mance. Shopping carts are an essential part of ecommerce, a minimal set of key performance indicators being the subject of our debate. The theoretical approach is sustained by a case study, an e-shop implemented using PHP and MySQL, for simulating main business processes within the considered performance framework. Our approach opens a perspective for future research using additional indicators in order to properly evaluate the global performance of any e-shop.

The cloudy bag model

International Nuclear Information System (INIS)

Thomas, A.W.

1981-01-01

Recent developments in the bag model, in which the constraints of chiral symmetry are explicitly included are reviewed. The model leads to a new understanding of the Δ-resonance. The connection of the theory with current algebra is clarified and implications of the model for the structure of the nucleon are discussed

Consumer behavior towards Online shopping of electronics in pakistan

OpenAIRE

BASHIR, ADIL

2013-01-01

E-commerce has made life simple and innovative of individuals and groups; consumer Behavior in online shopping is different from the physical market where he has access to see the product. The purpose of the research was to study the consumer behavior in online shopping of electronics especially in Pakistan. The main research question in thesis is how consumers behave while shopping online. Primary data was collected through the questionnaire survey and by emails from personal contacts in...

Influence of visualization on consumption during on-line shopping

OpenAIRE

Hictaler, Urška

2013-01-01

This diploma work studies the influence of visualization on consumption during on-line shopping. The first part of the thesis starts with key areas of visualization, consumption and on-line shopping. Visualization, areas of use, human perception and ways of product presentation in on-line shops are defined discussed first. Next, consumption, consumers and factors that influence their decisions and satisfaction are defined. The last topic in the first part of the thesis discusses on-line shopp...

FUNGAL POPULATION, AFLATOXIN AND FREE FATTY ACID CONTENTS OF PEANUTS PACKED IN DIFFERENT BAG TYPES

Directory of Open Access Journals (Sweden)

SONIA S.P. BULAONG

2002-01-01

Full Text Available Shelled peanuts of Gajah var. with initial moisture content of 7% were stored at 11 kg/bag in four bag types namely: jute bag, polypropylene bag, jute bag doubled with thin polyethylene (PE, and jute bag doubled with thick PE. Storage was done for six months under warehouse conditions with monitoring of relative humidity and temperature. Samples taken at the be ginning of storage and every month thereafter were analyzed for moisture content, fungal population, aflatoxin and free fatty acid contents. Statistical analyses showed that moisture content, fungal population, and free fatty acid contents were signifi cantly higher in jute and polypropylene bags than in PE-dou,bled jute bags. No significant differences were obtained in aflatoxin contents among bag types but at the end of six months storage, toxin level in jute bag exceeded the 30 ppb limit. Polypropylene had second highest toxin level at 23 ppb. The PE-doubled bags ha d 17 and 19 ppb total aflatoxins for thin and thick films, respectively. The results indicated that the immediate packag ing of dried shelled peanuts at safe moisture level in plastic films with water vapor transmission rated of 1 g/m2/24 hr or lower is recommended. This p ackaging will delay critical increases in moisture content, fungal population, aflatoxin and free fatty acid contents of peanut kernels at ambient storage conditions.

Shopping intention prediction using decision trees

OpenAIRE

Šebalj, Dario; Franjković, Jelena; Hodak, Kristina

2017-01-01

Introduction: The price is considered to be neglected marketing mix element due to the complexity of price management and sensitivity of customers on price changes. It pulls the fastest customer reactions to that change. Accordingly, the process of making shopping decisions can be very challenging for customer.Objective: The aim of this paper is to create a model that is able to predict shopping intention and classify respondents into one of the two categories, depending on whether they inten...

Bagworm bags as portable armour against invertebrate predators

OpenAIRE

Sugiura, Shinji

2016-01-01

Some animals have evolved the use of environmental materials as “portable armour” against natural enemies. Portable bags that bagworm larvae (Lepidoptera: Psychidae) construct using their own silk and plant parts are generally believed to play an important role as a physical barrier against natural enemies. However, no experimental studies have tested the importance of bags as portable armour against predators. To clarify the defensive function, I studied the bagworm Eumeta minuscula and a po...

Properties of hybrid stars in an extended MIT bag model

International Nuclear Information System (INIS)

Bao Tmurbagan; Liu Guangzhou; Zhu Mingfeng

2009-01-01

The properties of hybrid stars are investigated in the framework of the relativistic mean field theory (RMFT) and an MIT bag model with density-dependent bag constant to describe the hadron phase (HP) and quark phase (QP), respectively. We find that the density-dependent B(ρ) decreases with baryon density ρ; this decrement makes the strange quark matter become more energetically favorable than ever; which makes the threshold densities of the hadron-quark phase transition lower than those of the original bag constant case. In this case, the hyperon degrees of freedom can not be considered. As a result, the equations of state of a star in the mixed phase (MP) become softer whereas those in the QP become stiffer, and the radii of the star obviously decrease. This indicates that the extended MIT bag model is more suitable to describe hybrid stars with small radii. (authors)

Constraint-based job shop scheduling with ILOG SCHEDULER

NARCIS (Netherlands)

Nuijten, W.P.M.; Le Pape, C.

1998-01-01

We introduce constraint-based scheduling and discuss its main principles. An approximation algorithm based on tree search is developed for the job shop scheduling problem using ILOG SCHEDULER. A new way of calculating lower bounds on the makespan of the job shop scheduling problem is presented and

Assessment of the permeability properties of cryopreservation outer bags used in NHSBT.

Science.gov (United States)

Hogg, P; Rooney, P; Lomas, R; Kearney, J N

2018-01-12

This study was carried out to investigate leakage/transport across the bag material of six outer cryopreservation bags in common use within NHS Blood and Transplant. In order to do this two different leak testing procedures; coloured dye and hydrogen tracer gas, were used. The data obtained show that a coloured dye cannot permeate through the materials both at room temperature and following storage at liquid nitrogen temperature (- 196 °C). In addition, when filled with the smallest elemental molecule, hydrogen, in the form of a tracer gas, all of the bags only allowed trace amounts of hydrogen to escape, either through the seal or the bag material. The data indicated that each of the bag materials tested would be capable of preventing bacterial or viral cross-contamination as long as the material remained intact.

Dynamics of cesium-134 and biomass in treated and untreated turkey oak leaf-litter bags

International Nuclear Information System (INIS)

Croom, J.M.; Ragsdale, H.L.

1978-01-01

Litter bags were prepared from leaves harvested in late fall from turkey oak trees (Quercus laevis) tagged with 134 Cs. Untreated bags and bags treated by soaking in 1000 ppM HgCl 2 were placed in the field on Dec. 7, 1974. Five bags of each treatment were retrieved at 7-, 14-, and 30-day intervals as the experiment progressed. Treated bags remained free of visible fungal hyphae growth for 12 weeks. Untreated bags had lost more weight but less 134 Cs than treated bags after 14 and 56 days, respectively. After 9 months, untreated bags had lost 33% weight and 90% 134 Cs. Although 134 Cs is rapidly leached from litter (ecological half-life approximately equal to 12 weeks), some is retained by fungal hyphae on leaf-litter surfaces. This mechanism of mineral retention in the litter layer could represent adaptation at the ecosystem level for nutrient conservation

Bucket Brigades to Increase Productivity in a Luxury Assembly Line

OpenAIRE

Carlo, Filippo De; Borgia, Orlando; Tucci, Mario

2013-01-01

One of the most challenging issues in manual assembly lines is to achieve the best balance of workloads. There are many analytic approaches to solve this problem, but they are often neglected, since they are time-consuming and require high level engineering skills. Fashion bags packaging lines must comply with a number of different products with low production volumes, while the organization of the line is often under the mere responsibility of the foreman, who balances workloads in an empiri...

Zero-point motion in the bag description of the nucleon

International Nuclear Information System (INIS)

Brown, G.E.; Durso, J.W.; Johnson, M.B.

1983-01-01

In the bag model, confinement of quarks is accomplished by introduction of a boundary condition at some definite radius R, where the energy of the total system is a minimum. This minimum is, however, relatively shallow and energies for substantially different bag radii are not much larger than this minimum value. This indicates that the zero-point motion of the bag surface may be important. In this paper, quantization of the bag surface motion is carried out in a somewhat ad hoc fashion, modelled after the generator coordinate theory in nuclear physics. This procedure unifies a number of ideas previously in the literature; it stresses the anharmonicity of the collective motion. As in earlier treatments, the Roper resonance emerges as a breathing-mode type of excitation of the nucleon. The one- and two-pion decays of the Roper resonance are calculated and the widths are found to fall short of the empirical ones. It is pointed out, however, that decays involving intermediate states containing virtual rho-mesons will enhance the widths. Pion-nucleon scattering in the P 11 channel is constructed in our model and found to agree roughly with experiment. A crucial term in the driving force involves the pion coupling to the nucleon through a virtual rho-meson. With introduction of zero-point motion of the bag surface, the motion of 'bag radius' becomes dependent on precisely which moment of the radius is measured. Our development gives a model for cutting off smoothly the pion-exchange term in the nucleon-nucleon interaction. (orig.)

Pionic corrections to the MIT bag model: The (3,3) resonance

International Nuclear Information System (INIS)

Theberge, S.; Thomas, A.W.; Miller, G.A.

1980-01-01

By incorporating chiral invariance in the MIT bag model, we are led to a theory in which the pion field is coupled to the confined quarks only at the bag surface. An equivalent quantized theory of nucleons and Δ's interacting with pions is then obtained. The pion-nucleon scattering amplitude in this model is found to give a good fit to experimental data on the (3,3) resonance, with a bag radius of about 0.72 fm

BAG3 myofibrillar myopathy presenting with cardiomyopathy.

Science.gov (United States)

Konersman, Chamindra G; Bordini, Brett J; Scharer, Gunter; Lawlor, Michael W; Zangwill, Steven; Southern, James F; Amos, Louella; Geddes, Gabrielle C; Kliegman, Robert; Collins, Michael P

2015-05-01

Myofibrillar myopathies (MFMs) are a heterogeneous group of neuromuscular disorders distinguished by the pathological hallmark of myofibrillar dissolution. Most patients present in adulthood, but mutations in several genes including BCL2-associated athanogene 3 (BAG3) cause predominantly childhood-onset disease. BAG3-related MFM is particularly severe, featuring weakness, cardiomyopathy, neuropathy, and early lethality. While prior cases reported either neuromuscular weakness or concurrent weakness and cardiomyopathy at onset, we describe the first case in which cardiomyopathy and cardiac transplantation (age eight) preceded neuromuscular weakness by several years (age 12). The phenotype comprised distal weakness and severe sensorimotor neuropathy. Nerve biopsy was primarily axonal with secondary demyelinating/remyelinating changes without "giant axons." Muscle biopsy showed extensive neuropathic changes that made myopathic changes difficult to interpret. Similar to previous cases, a p.Pro209Leu mutation in exon 3 of BAG3 was found. This case underlines the importance of evaluating for MFMs in patients with combined neuromuscular weakness and cardiomyopathy. Copyright © 2015 Elsevier B.V. All rights reserved.

Price learning during grocery shopping

DEFF Research Database (Denmark)

Jensen, Birger Boutrup

Many attempts have been made to measure consumers' price knowledge for groceries. However, the results have varied considerably and conflict with results of reference price research. This is the first study to examine price knowledge before, during, and after store visit, thus enabling a study...... of what consumers learn about prices during grocery shopping. Three measures of price knowledge corresponding to different levels of price information processing were applied. Results indicate that price learning does take place and that episodic price knowledge after store exit is far more widespread...... than expected. Consequently, a new view of how consumer price knowledge evolves during grocery shopping is presented....

Bird-resistant pollination bags for sorghum breeding and germplasm maintenance

Science.gov (United States)

Bird damage is a problem in sorghum breeding and germplasm maintenance operations. Paper pollination bags are damaged by rain and provide minimal deterrent to birds. To overcome these limitations we fabricated pollination bags from spun polyethylene fiber sheeting. Seed loss by bird damage was elimi...

When Is a New Scale not a New Scale? The Case of the Bergen Shopping Addiction Scale and the Compulsive Online Shopping Scale.

Science.gov (United States)

Griffiths, Mark D; Andreassen, Cecilie S; Pallesen, Ståle; Bilder, Robert M; Torsheim, Torbjørn; Aboujaoude, Elias

2016-01-01

Manchiraju et al. ( International Journal of Mental Health and Addiction , 1-15, 2016) published the Compulsive Online Shopping Scale (COSS) in the International Journal of Mental Health and Addiction ( IJMHA ). To develop their measure of compulsive online shopping, Manchiraju and colleagues adapted items from the seven-item Bergen Shopping Addiction Scale (BSAS) and its' original 28-item item pool. Manchiraju et al. did not add or remove any of the original seven items, and did not substantially change the content of any of the 28 items on which the BSAS was based. They simply added the word "online" to each existing item. Given that the BSAS was specifically developed to take into account the different ways in which people now shop and to include both online and offline shopping, there does not seem to be a good rationale for developing an online version of the BSAS. It is argued that the COSS is not really an adaptation of the BSAS but an almost identical instrument based on the original 28-item pool.