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Sample records for shock increases systemic

  1. System Shock: The Archetype of Operational Shock

    Science.gov (United States)

    2017-05-25

    the battle space. They can also facilitate a much greater understanding of the variables involved in each party’s decision - making process. However...system shock nests within current US Army Unified Land Operations doctrine. In order to test the utility of system shock theory to Gray Zone...23 Neil E. Harrison, “Thinking about the World We Make ” in Chaos Theory in the Social Sciences: Foundations and Applications

  2. Remote shock sensing and notification system

    Science.gov (United States)

    Muralidharan, Govindarajan; Britton, Charles L.; Pearce, James; Jagadish, Usha; Sikka, Vinod K.

    2008-11-11

    A low-power shock sensing system includes at least one shock sensor physically coupled to a chemical storage tank to be monitored for impacts, and an RF transmitter which is in a low-power idle state in the absence of a triggering signal. The system includes interference circuitry including or activated by the shock sensor, wherein an output of the interface circuitry is coupled to an input of the RF transmitter. The interface circuitry triggers the RF transmitting with the triggering signal to transmit an alarm message to at least one remote location when the sensor senses a shock greater than a predetermined threshold. In one embodiment the shock sensor is a shock switch which provides an open and a closed state, the open state being a low power idle state.

  3. SELF-REGULATED SHOCKS IN MASSIVE STAR BINARY SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    Parkin, E. R.; Sim, S. A., E-mail: parkin@mso.anu.edu.au, E-mail: s.sim@qub.ac.uk [Research School of Astronomy and Astrophysics, Australian National University, ACT 2611 (Australia)

    2013-04-20

    In an early-type, massive star binary system, X-ray bright shocks result from the powerful collision of stellar winds driven by radiation pressure on spectral line transitions. We examine the influence of the X-rays from the wind-wind collision shocks on the radiative driving of the stellar winds using steady-state models that include a parameterized line force with X-ray ionization dependence. Our primary result is that X-ray radiation from the shocks inhibits wind acceleration and can lead to a lower pre-shock velocity, and a correspondingly lower shocked plasma temperature, yet the intrinsic X-ray luminosity of the shocks, L{sub X}, remains largely unaltered, with the exception of a modest increase at small binary separations. Due to the feedback loop between the ionizing X-rays from the shocks and the wind driving, we term this scenario as self-regulated shocks. This effect is found to greatly increase the range of binary separations at which a wind-photosphere collision is likely to occur in systems where the momenta of the two winds are significantly different. Furthermore, the excessive levels of X-ray ionization close to the shocks completely suppress the line force, and we suggest that this may render radiative braking less effective. Comparisons of model results against observations reveal reasonable agreement in terms of log (L{sub X}/L{sub bol}). The inclusion of self-regulated shocks improves the match for kT values in roughly equal wind momenta systems, but there is a systematic offset for systems with unequal wind momenta (if considered to be a wind-photosphere collision).

  4. SELF-REGULATED SHOCKS IN MASSIVE STAR BINARY SYSTEMS

    International Nuclear Information System (INIS)

    Parkin, E. R.; Sim, S. A.

    2013-01-01

    In an early-type, massive star binary system, X-ray bright shocks result from the powerful collision of stellar winds driven by radiation pressure on spectral line transitions. We examine the influence of the X-rays from the wind-wind collision shocks on the radiative driving of the stellar winds using steady-state models that include a parameterized line force with X-ray ionization dependence. Our primary result is that X-ray radiation from the shocks inhibits wind acceleration and can lead to a lower pre-shock velocity, and a correspondingly lower shocked plasma temperature, yet the intrinsic X-ray luminosity of the shocks, L X , remains largely unaltered, with the exception of a modest increase at small binary separations. Due to the feedback loop between the ionizing X-rays from the shocks and the wind driving, we term this scenario as self-regulated shocks. This effect is found to greatly increase the range of binary separations at which a wind-photosphere collision is likely to occur in systems where the momenta of the two winds are significantly different. Furthermore, the excessive levels of X-ray ionization close to the shocks completely suppress the line force, and we suggest that this may render radiative braking less effective. Comparisons of model results against observations reveal reasonable agreement in terms of log (L X /L bol ). The inclusion of self-regulated shocks improves the match for kT values in roughly equal wind momenta systems, but there is a systematic offset for systems with unequal wind momenta (if considered to be a wind-photosphere collision).

  5. Lunar Surface Potential Increases during Terrestrial Bow Shock Traversals

    Science.gov (United States)

    Collier, Michael R.; Stubbs, Timothy J.; Hills, H. Kent; Halekas, Jasper; Farrell, William M.; Delory, Greg T.; Espley, Jared; Freeman, John W.; Vondrak, Richard R.; Kasper, Justin

    2009-01-01

    Since the Apollo era the electric potential of the Moon has been a subject of interest and debate. Deployed by three Apollo missions, Apollo 12, Apollo 14 and Apollo 15, the Suprathermal Ion Detector Experiment (SIDE) determined the sunlit lunar surface potential to be about +10 Volts using the energy spectra of lunar ionospheric thermal ions accelerated toward the Moon. We present an analysis of Apollo 14 SIDE "resonance" events that indicate the lunar surface potential increases when the Moon traverses the dawn bow shock. By analyzing Wind spacecraft crossings of the terrestrial bow shock at approximately this location and employing current balancing models of the lunar surface, we suggest causes for the increasing potential. Determining the origin of this phenomenon will improve our ability to predict the lunar surface potential in support of human exploration as well as provide models for the behavior of other airless bodies when they traverse similar features such as interplanetary shocks, both of which are goals of the NASA Lunar Science Institute's Dynamic Response of the Environment At the Moon (DREAM) team.

  6. Low-energy proton increases associated with interplanetary shock waves.

    Science.gov (United States)

    Palmeira, R. A. R.; Allum, F. R.; Rao, U. R.

    1971-01-01

    Impulsive increases in the low energy proton flux observed by the Explorer 34 satellite, in very close time association with geomagnetic storm sudden commencements are described. It is shown that these events are of short duration (20-30 min) and occur only during the decay phase of a solar cosmic-ray flare event. The differential energy spectrum and the angular distribution of the direction of arrival of the particles are discussed. Two similar increases observed far away from the earth by the Pioneer 7 and 8 deep-space probes are also presented. These impulsive increases are compared with Energetic Storm Particle events and their similarities and differences are discussed. A model is suggested to explain these increases, based on the sweeping and trapping of low energy cosmic rays of solar origin by the advancing shock front responsible for the sudden commencement detected on the earth.

  7. Shock waves in collective field theories for many particle systems

    Energy Technology Data Exchange (ETDEWEB)

    Oki, F; Saito, T [Kyoto Prefectural Univ. of Medicine (Japan); Shigemoto, K

    1980-10-01

    We find shock wave solutions to collective field equations for quantum mechanical many particle system. Importance of the existence of a ''tension'' working on the surface of the shock-wave front is pointed out.

  8. Towards an understanding of resilience: responding to health systems shocks.

    Science.gov (United States)

    Hanefeld, Johanna; Mayhew, Susannah; Legido-Quigley, Helena; Martineau, Frederick; Karanikolos, Marina; Blanchet, Karl; Liverani, Marco; Yei Mokuwa, Esther; McKay, Gillian; Balabanova, Dina

    2018-04-01

    The recent outbreak of Ebola Virus Disease (EVD) in West Africa has drawn attention to the role and responsiveness of health systems in the face of shock. It brought into sharp focus the idea that health systems need not only to be stronger but also more 'resilient'. In this article, we argue that responding to shocks is an important aspect of resilience, examining the health system behaviour in the face of four types of contemporary shocks: the financial crisis in Europe from 2008 onwards; climate change disasters; the EVD outbreak in West Africa 2013-16; and the recent refugee and migration crisis in Europe. Based on this analysis, we identify '3 plus 2' critical dimensions of particular relevance to health systems' ability to adapt and respond to shocks; actions in all of these will determine the extent to which a response is successful. These are three core dimensions corresponding to three health systems functions: 'health information systems' (having the information and the knowledge to make a decision on what needs to be done); 'funding/financing mechanisms' (investing or mobilising resources to fund a response); and 'health workforce' (who should plan and implement it and how). These intersect with two cross-cutting aspects: 'governance', as a fundamental function affecting all other system dimensions; and predominant 'values' shaping the response, and how it is experienced at individual and community levels. Moreover, across the crises examined here, integration within the health system contributed to resilience, as does connecting with local communities, evidenced by successful community responses to Ebola and social movements responding to the financial crisis. In all crises, inequalities grew, yet our evidence also highlights that the impact of shocks is amenable to government action. All these factors are shaped by context. We argue that the '3 plus 2' dimensions can inform pragmatic policies seeking to increase health systems resilience.

  9. Shock propagation in locally driven granular systems

    Science.gov (United States)

    Joy, Jilmy P.; Pathak, Sudhir N.; Das, Dibyendu; Rajesh, R.

    2017-09-01

    We study shock propagation in a system of initially stationary hard spheres that is driven by a continuous injection of particles at the origin. The disturbance created by the injection of energy spreads radially outward through collisions between particles. Using scaling arguments, we determine the exponent characterizing the power-law growth of this disturbance in all dimensions. The scaling functions describing the various physical quantities are determined using large-scale event-driven simulations in two and three dimensions for both elastic and inelastic systems. The results are shown to describe well the data from two different experiments on granular systems that are similarly driven.

  10. Shock and vibration technology with applications to electrical systems

    Science.gov (United States)

    Eshleman, R. L.

    1972-01-01

    A survey is presented of shock and vibration technology for electrical systems developed by the aerospace programs. The shock environment is surveyed along with new techniques for modeling, computer simulation, damping, and response analysis. Design techniques based on the use of analog computers, shock spectra, optimization, and nonlinear isolation are discussed. Shock mounting of rotors for performance and survival, and vibration isolation techniques are reviewed.

  11. Integration of regenerative shock absorber into vehicle electric system

    Science.gov (United States)

    Zhang, Chongxiao; Li, Peng; Xing, Shaoxu; Kim, Junyoung; Yu, Liangyao; Zuo, Lei

    2014-03-01

    Regenerative/Energy harvesting shock absorbers have a great potential to increase fuel efficiency and provide suspension damping simultaneously. In recent years there's intensive work on this topic, but most researches focus on electricity extraction from vibration and harvesting efficiency improvement. The integration of electricity generated from regenerative shock absorbers into vehicle electric system, which is very important to realize the fuel efficiency benefit, has not been investigated. This paper is to study and demonstrate the integration of regenerative shock absorber with vehicle alternator, battery and in-vehicle electrical load together. In the presented system, the shock absorber is excited by a shaker and it converts kinetic energy into electricity. The harvested electricity flows into a DC/DC converter which realizes two functions: controlling the shock absorber's damping and regulating the output voltage. The damping is tuned by controlling shock absorber's output current, which is also the input current of DC/DC converter. By adjusting the duty cycles of switches in the converter, its input impedance together with input current can be adjusted according to dynamic damping requirements. An automotive lead-acid battery is charged by the DC/DC converter's output. To simulate the working condition of combustion engine, an AC motor is used to drive a truck alternator, which also charges the battery. Power resistors are used as battery's electrical load to simulate in-vehicle electrical devices. Experimental results show that the proposed integration strategy can effectively utilize the harvested electricity and power consumption of the AC motor is decreased accordingly. This proves the combustion engine's load reduction and fuel efficiency improvement.

  12. Underwater hydraulic shock shovel control system

    Science.gov (United States)

    Liu, He-Ping; Luo, A.-Ni; Xiao, Hai-Yan

    2008-06-01

    The control system determines the effectiveness of an underwater hydraulic shock shovel. This paper begins by analyzing the working principles of these shovels and explains the importance of their control systems. A new type of control system’s mathematical model was built and analyzed according to those principles. Since the initial control system’s response time could not fulfill the design requirements, a PID controller was added to the control system. System response time was still slower than required, so a neural network was added to nonlinearly regulate the proportional element, integral element and derivative element coefficients of the PID controller. After these improvements to the control system, system parameters fulfilled the design requirements. The working performance of electrically-controlled parts such as the rapidly moving high speed switch valve is largely determined by the control system. Normal control methods generally can’t satisfy a shovel’s requirements, so advanced and normal control methods were combined to improve the control system, bringing good results.

  13. out-of-n systems with shock model

    African Journals Online (AJOL)

    distributed. Sarhan, A.M. and Abouammoh (2000) used the shock model to derive the re- liability function of k-out-of-n systems with nonindependent and nonidentical components. They assumed that a system is subjected to n + m independent types of shocks. Liu et al. (2008) proposed a model to evaluate the reliability ...

  14. Toxoplasma gondii 70 kDa heat shock protein: systemic detection is associated with the death of the parasites by the immune response and its increased expression in the brain is associated with parasite replication.

    Directory of Open Access Journals (Sweden)

    Paulo Victor Czarnewski Barenco

    Full Text Available The heat shock protein of Toxoplasma gondii (TgHSP70 is a parasite virulence factor that is expressed during T. gondii stage conversion. To verify the effect of dexamethasone (DXM-induced infection reactivation in the TgHSP70-specific humoral immune response and the presence of the protein in the mouse brain, we produced recombinant TgHSP70 and anti-TgHSP70 IgY antibodies to detect the protein, the specific antibody and levels of immune complexes (ICs systemically, as well as the protein in the brain of resistant (BALB/c and susceptible (C57BL/6 mice. It was observed higher TgHSP70-specific antibody titers in serum samples of BALB/c compared with C57BL/6 mice. However, the susceptible mice presented the highest levels of TgHSP70 systemically and no detection of specific ICs. The DXM treatment induced increased parasitism and lower inflammatory changes in the brain of C57BL/6, but did not interfere with the cerebral parasitism in BALB/c mice. Additionally, DXM treatment decreased the serological TgHSP70 concentration in both mouse lineages. C57BL/6 mice presented high expression of TgHSP70 in the brain with the progression of infection and under DXM treatment. Taken together, these data indicate that the TgHSP70 release into the bloodstream depends on the death of the parasites mediated by the host immune response, whereas the increased TgHSP70 expression in the brain depends on the multiplication rate of the parasite.

  15. Shock disturbance of the I-Xe system

    International Nuclear Information System (INIS)

    Caffee, M.W.; Hohenberg, C.M.; Podosek, F.A.; Swindle, T.D.

    1982-01-01

    Three separate samples of the meteorite Bjurbole were artificially shocked at pressures of 70 kb, 200 kb, and 400 kb. Analysis of xenon released in stepwise heating shows that the I-Xe system of the 400 kb sample is substantially altered by the shock loading, and it is no longer possible to infer an age or trapped xenon composition for that sample. The 200-kb and 70-kb samples display isotopic structures progressively less altered demonstrating the gradations in shock disturbance likely to be found in natural systems. Interpretations of the I-Xe and Ar-40-Ar-39 systems for several naturally shocked meteorites are also presented. New data for Arapahoe do not confirm the previously reported age and trapped xenon composition, demonstrating instead that its I-Xe structure has been strongly disturbed by shock

  16. Compact all-fiber interferometer system for shock acceleration measurement

    Science.gov (United States)

    Zhao, Jiang; Pi, Shaohua; Hong, Guangwei; Zhao, Dong; Jia, Bo

    2013-08-01

    Acceleration measurement plays an important role in a variety of fields in science and engineering. In particular, the accurate, continuous and non-contact recording of the shock acceleration profiles of the free target surfaces is considered as a critical technique in shock physics. Various kinds of optical interferometers have been developed to monitor the motion of the surfaces of shocked targets since the 1960s, for instance, the velocity interferometer system for any reflector, the fiber optic accelerometer, the photonic Doppler velocimetry system and the displacement interferometer. However, most of such systems rely on the coherent quasi-monochromatic illumination and discrete optic elements, which are costly in setting-up and maintenance. In 1996, L. Levin et al reported an interferometric fiber-optic Doppler velocimeter with high-dynamic range, in which fiber-coupled components were used to replace the discrete optic elements. However, the fringe visibility of the Levin's system is low because of the coupled components, which greatly limits the reliability and accuracy in the shock measurement. In this paper, a compact all-fiber interferometer system for measuring the shock acceleration is developed and tested. The advantage of the system is that not only removes the non-interfering light and enhances the fringe visibility, but also reduces polarization induced signal fading and the polarization induced phase shift. Moreover, it also does not require a source of long coherence length. The system bases entirely on single-mode fiber optics and mainly consists of a polarization beam splitter, a faraday rotator, a depolarizer and a 3×3 single-mode fiber coupler which work at 1310 nm wavelength. The optical systems of the interferometer are described and the experimental results compared with a shock acceleration calibration system with a pneumatic exciter (PneuShockTM Model 9525C by The Modal Shop) are reported. In the shock acceleration test, the

  17. Banking System Shocks and REIT Performance

    OpenAIRE

    Olliges, Jan-Willem; Raudszus, Malte H.; Mueller, Glenn R.

    2013-01-01

    The purpose of this study is to directly contrast the REIT market’s stock return response to bank failures versus bank bailouts. The non-negativity constraints of the GARCH model measuring risk dynamics are mitigated by the use of the EGARCH model. EGARCH accounts for non-symmetrical effects of risk adjustments in response to return shocks. Previous research shows that bank failures cause a positive abnormal return effect for REITs. This confirms the expectation that during crises, market par...

  18. Development of a Novel Shock Wave Catheter Ablation System

    Science.gov (United States)

    Yamamoto, H.; Hasebe, Yuhi; Kondo, Masateru; Fukuda, Koji; Takayama, Kazuyoshi; Shimokawa, Hiroaki

    Although radio-frequency catheter ablation (RFCA) is quite effective for the treatment tachyarrhythmias, it possesses two fundamental limitations, including limited efficacy for the treatment of ventricular tachyarrhythmias of epicardial origin and the risk of thromboembolism. Consequently, new method is required, which can eradicate arrhythmia source in deep part of cardiac muscle without heating. On the other hand, for a medical application of shock waves, extracorporeal shock wave lithotripter (ESWL) has been established [1]. It was demonstrated that the underwater shock focusing is one of most efficient method to generate a controlled high pressure in a small region [2]. In order to overcome limitations of existing methods, we aimed to develop a new catheter ablation system with underwater shock waves that can treat myocardium at arbitrary depth without causing heat.

  19. Shock absorber system for nuclear reactor ice condenser compartment

    International Nuclear Information System (INIS)

    Meier, J.F.; Rudd, G.E.; Pradhan, A.V.; George, J.A.; Lippincott, H.W.; Sutherland, J.D.

    1979-01-01

    A shock absorber system was designed to absorb the energy imparted to doors in a nuclear reactor ice condenser compartment as they swing rapidly to an open position. Each shock absorber which is installed on a wall adjacent to each door is large and must absorb up to about 40,000 foot pounds of energy. The basic shock absorber component comprises foam enclosed in a synthetic fabric bag having a volume about twice the foam volume. A stainless steel knitted mesh bag of the same volume as the fabric bag, contains the fabric bag and its enclosed foam. To protect the foam and bags during construction activities at the reactor site and from the shearing action of the doors, a protective sheet metal cover is installed over the shock absorber ends and the surface to be contacted by the moving door. With the above shock absorber mounted on a wall behind each door, as the door is forcibly opened by steam pressure and air resulting from a pipe break in the reactor compartment, it swings at a high velocity into contact with the shock absorber, crushes the foam and forces it into the fabric bag excess material thus containing the foam fragmented particles, and minimizes build-up of pressure in the bag as a result of the applied compressive force

  20. Shock to the system: Restructuring America's electricity industry

    International Nuclear Information System (INIS)

    Brennan, T.J.; Palmer, K.L.; Kopp, R.J.; Krupnick, A.J.; Stagliano, V.

    1996-01-01

    Recent decades have seen revolutions in communications, finance, and transportation. In a similar way, technological, economic, and political developments are reshaping the US electricity industry. This concise, balanced, and readable primer, produced by a team of economic analysts at Resources for the Future, introduces the concepts, crucial elements, and terminology used in discussions about electricity restructuring. A Shock to the System provides the background necessary to understand the increasing role of competition in electricity markets. The authors present the history of public policy regarding electricity, identify the significant proposals for implementing competition, and examine their potential consequences for utility regulation, industry structure, cost recovery, and the environment. This volume is an instructive guide to the decisions that electricity providers, customers, and policy makers will face, what forms the decisions are likely to take, and what the long-term ramifications may be

  1. Endogenous versus exogenous shocks in systems with memory

    Science.gov (United States)

    Sornette, D.; Helmstetter, A.

    2003-02-01

    Systems with long-range persistence and memory are shown to exhibit different precursory as well as recovery patterns in response to shocks of exogenous versus endogenous origins. By endogenous, we envision either fluctuations resulting from an underlying chaotic dynamics or from a stochastic forcing origin which may be external or be an effective coarse-grained description of the microscopic fluctuations. In this scenario, endogenous shocks result from a kind of constructive interference of accumulated fluctuations whose impacts survive longer than the large shocks themselves. As a consequence, the recovery after an endogenous shock is in general slower at early times and can be at long times either slower or faster than after an exogenous perturbation. This offers the tantalizing possibility of distinguishing between an endogenous versus exogenous cause of a given shock, even when there is no “smoking gun”. This could help in investigating the exogenous versus self-organized origins in problems such as the causes of major biological extinctions, of change of weather regimes and of the climate, in tracing the source of social upheaval and wars, and so on. Sornette et al., Volatility fingerprints of large stocks: endogenous versus exogenous, cond-mat/0204626 has already shown how this concept can be applied concretely to differentiate the effects on financial markets of the 11 September 2001 attack or of the coup against Gorbachev on 19 August 1991 (exogenous) from financial crashes such as October 1987 (endogenous).

  2. Slow shocks and their transition to fast shocks in the inner solar wind

    International Nuclear Information System (INIS)

    Wang, Y.C.

    1987-01-01

    The jump conditions of MHD shocks may be directly calculated as functions of three upstream conditions: the shock Alfven number based on the normal component of the relative shock speed, the shock angle, and the plasma β value. The shock Alfven number is less than 1 for a slow shock and greater than 1 for a fast shock. A traveling, forward shock can be a slow shock in coronal space, where the Alfven speed is of the order of 1000 km/s. The surface of a forward slow shock has a bow-shaped geometry with its nose facing toward the sun. The decrease in the Alfven speed at increasing heliocentric distance causes the shock Alfven number of a forward slow shock to become greater than 1, and the shock eventually evolves from a slow shock into a fast shock. During the transition the shock system consists of a slow shock, a fast shock, and a rotational discontinuity. They intersect along a closed transition line. As the system moves outward from the sun, the area enclosed by the transition line expands, the fast shock grows stronger, and the slow shock becomes weaker. Eventually, the slow shock diminishes, and the entire shock system evolves into a forward fast shock. copyrightAmerican Geophysical Union 1987

  3. Preview control of vehicle suspension system featuring MR shock absorber

    Energy Technology Data Exchange (ETDEWEB)

    Seong, M S; Choi, S B [Smart Structures and Systems Laboratory, Department of Mechanical Engineering, Inha University, Incheon 402-751 (Korea, Republic of); Cho, M W [Precision Manufacturing and Inspection Laboratory, Department of Mechanical Engineering, Inha University, Incheon 402-751 (Korea, Republic of); Lee, H G [Department of Automotive Engineering, Daeduk College, Daejeon, 305-715 (Korea, Republic of)], E-mail: seungbok@inha.ac.kr

    2009-02-01

    This paper presents control performance evaluation of optimal preview control algorithm for vehicle suspension featuring MR shock absorber. The optimal preview control algorithm has several advantages such as high control performance over that which is best for a non-preview system. In order to achieve this goal, a commercial MR shock absorber, Delphi MganerideTM, which is applicable to high class passenger vehicle, is adopted and its field-dependent damping force and dynamic responses are experimentally evaluated. Then the governing equation of motion for the full-vehicle model is established and integrated with the MR shock absorber. Subsequently, optimal controller with preview control algorithm is formulated and implemented for vibration suppression of the car body. Control performance of the preview controller is evaluated for the full-vehicle model under random road condition. In addition, the control performances depending on preview distances are evaluated.

  4. Preview control of vehicle suspension system featuring MR shock absorber

    International Nuclear Information System (INIS)

    Seong, M S; Choi, S B; Cho, M W; Lee, H G

    2009-01-01

    This paper presents control performance evaluation of optimal preview control algorithm for vehicle suspension featuring MR shock absorber. The optimal preview control algorithm has several advantages such as high control performance over that which is best for a non-preview system. In order to achieve this goal, a commercial MR shock absorber, Delphi MganerideTM, which is applicable to high class passenger vehicle, is adopted and its field-dependent damping force and dynamic responses are experimentally evaluated. Then the governing equation of motion for the full-vehicle model is established and integrated with the MR shock absorber. Subsequently, optimal controller with preview control algorithm is formulated and implemented for vibration suppression of the car body. Control performance of the preview controller is evaluated for the full-vehicle model under random road condition. In addition, the control performances depending on preview distances are evaluated.

  5. Gradually Increased Oxygen Administration Improved Oxygenation and Mitigated Oxidative Stress after Resuscitation from Severe Hemorrhagic Shock.

    Science.gov (United States)

    Luo, Xin; Yin, Yujing; You, Guoxing; Chen, Gan; Wang, Ying; Zhao, Jingxiang; Wang, Bo; Zhao, Lian; Zhou, Hong

    2015-11-01

    The optimal oxygen administration strategy during resuscitation from hemorrhagic shock (HS) is still controversial. Improving oxygenation and mitigating oxidative stress simultaneously seem to be contradictory goals. To maximize oxygen delivery while minimizing oxidative damage, the authors proposed the notion of gradually increased oxygen administration (GIOA), which entails making the arterial blood hypoxemic early in resuscitation and subsequently gradually increasing to hyperoxic, and compared its effects with normoxic resuscitation, hyperoxic resuscitation, and hypoxemic resuscitation in severe HS. Rats were subjected to HS, and on resuscitation, the rats were randomly assigned to four groups (n = 8): the normoxic, the hyperoxic, the hypoxemic, and the GIOA groups. Rats were observed for an additional 1 h. Hemodynamics, acid-base status, oxygenation, and oxidative injury were observed and evaluated. Central venous oxygen saturation promptly recovered only in the hyperoxic and the GIOA groups, and the liver tissue partial pressure of oxygen was highest in the GIOA group after resuscitation. Oxidative stress in GIOA group was significantly reduced compared with the hyperoxic group as indicated by the reduced malondialdehyde content, increased catalase activity, and the lower histologic injury scores in the liver. In addition, the tumor necrosis factor-α and interleukin-6 expressions in the liver were markedly decreased in the GIOA group than in the hyperoxic and normoxic groups as shown by the immunohistochemical staining. GIOA improved systemic/tissue oxygenation and mitigated oxidative stress simultaneously after resuscitation from severe HS. GIOA may be a promising strategy to improve resuscitation from HS and deserves further investigation.

  6. Digoxin Is Associated With Increased Shock Events and Electrical Storms in Patients With Implantable Cardioverter Defibrillators.

    Science.gov (United States)

    Mina, George S; Acharya, Madan; Shepherd, Taylor; Gobrial, George; Tekeste, Michael; Watti, Hussam; Bhandari, Ruchi; Saini, Aditya; Reddy, Pratap; Dominic, Paari

    2018-03-01

    Recently, digoxin use has been found to associate with higher mortality. Yet, potential mechanisms by which digoxin use increases mortality remain unclear. Increased arrhythmogenicity from digoxin use is one possibility. Thus, we aimed to evaluate the relation between digoxin and shock events in patients with implantable cardioverter defibrillators (ICDs). We performed a retrospective chart review of all patients with ICDs and at least 1 device interrogation at our institution between January 1, 2012, and January 1, 2015. We aimed to cover 1 year of interrogation period. Patients with heart failure, atrial fibrillation, or both were included in the analysis. Patients were divided into 2 groups based on digoxin use, defined as use of digoxin for any period of time during ICD interrogation period. Incidence of ICD shock events and electrical storms and hospitalizations were compared between the 2 groups. The study included 202 patients. Of those, 55 patients were on digoxin and 147 were not on digoxin. Patients on digoxin were more likely to receive ICD shocks (odds ratio [OR] = 2.5, 95% confidence interval [95% CI] = 1.01-6.18, P = .04) and have increased risk of electrical storms ( P = .02). Moreover, total hospitalizations were higher in digoxin users ( P = .02). Multivariate logistic regression analysis also showed that digoxin use was an independent predictor of shock events (OR = 4.07, 95% CI = 1.43-11.58, P = .009). Digoxin is associated with increased shock events and electrical storms in patients with ICDs; however, large randomized controlled studies are needed to confirm our findings.

  7. Plumbing system shock absorbers as a source of Legionella pneumophila.

    Science.gov (United States)

    Memish, Z A; Oxley, C; Contant, J; Garber, G E

    1992-12-01

    Water distribution systems have been demonstrated to be a major source of nosocomial legionellosis. We describe an outbreak in our institution in which a novel source of Legionella pneumophila was identified in the plumbing system. After an outbreak of 10 cases of legionellosis in our hospital, recommended measures including superheating of the hot water to 80 degrees C, hyperchlorination to 2 ppm, and flushing resulted in no new cases in the following 5 years. Recently, despite these control measures, three new cases occurred. Surveillance cultures of shower heads and water tanks were negative; cultures of tap water samples remained positive. This prompted a search for another reservoir. Shock absorbers installed within water pipes to decrease noise were suspected. One hundred twenty-five shock absorbers were removed and cultured. A total of 13 (10%) yielded heavy growth of L. pneumophila (serogroup 1). Since their removal, no new cases have been found and the percentage of positive results of random tap water culture has dropped from 20% to 5%. This is the first report that identifies shock absorbers as a possible reservoir for L. pneumophila. We recommend that institutions with endemic legionellosis assess the water system for possible removal of shock absorbers.

  8. Increased Risk of New-Onset Hypertension After Shock Wave Lithotripsy in Urolithiasis: A Nationwide Cohort Study.

    Science.gov (United States)

    Huang, Shi-Wei; Tsai, Chung-You; Wang, Jui; Pu, Yeong-Shiau; Chen, Pei-Chun; Huang, Chao-Yuan; Chien, Kuo-Liong

    2017-10-01

    Although shock wave lithotripsy is minimally invasive, earlier studies argued that it may increase patients' subsequent risk of hypertension and diabetes mellitus. This study evaluated the association between shock wave lithotripsy and new-onset hypertension or diabetes mellitus. The Taiwanese National Health Insurance Research Database was used to identify 20 219 patients aged 18 to 65 years who underwent the first stone surgical treatment (shock wave lithotripsy or ureterorenoscopic lithotripsy) between January 1999 and December 2011. A Cox proportional model was applied to evaluate associations. Time-varying Cox models were applied to evaluate the association between the number of shock wave lithotripsy sessions and the incidence of hypertension or diabetes mellitus. After a median follow-up of 74.9 and 82.6 months, 2028 and 688 patients developed hypertension in the shock wave lithotripsy and ureterorenoscopic lithotripsy groups, respectively. Patients who underwent shock wave lithotripsy had a higher probability of developing hypertension than patients who underwent ureterorenoscopic lithotripsy, with a hazard ratio of 1.20 (95% confidence interval, 1.10-1.31) after adjusting for covariates. The risk increased as the number of shock wave lithotripsy sessions increased. However, the diabetes mellitus risk was similar in the shock wave lithotripsy and ureterorenoscopic lithotripsy groups. Furthermore, the hazard ratio did not increase as the number of shock wave lithotripsy sessions increased. Shock wave lithotripsy consistently increased the incidence of hypertension on long-term follow-up. Therefore, alternatives to urolithiasis treatment (eg, endoscopic surgery or medical expulsion therapy) could avoid the hypertension risk. Furthermore, avoiding multiple sessions of shock wave lithotripsy could also evade the hypertension risk. © 2017 American Heart Association, Inc.

  9. Resveratrol Reactivates Latent HIV through Increasing Histone Acetylation and Activating Heat Shock Factor 1.

    Science.gov (United States)

    Zeng, Xiaoyun; Pan, Xiaoyan; Xu, Xinfeng; Lin, Jian; Que, Fuchang; Tian, Yuanxin; Li, Lin; Liu, Shuwen

    2017-06-07

    The persistence of latent HIV reservoirs presents a significant challenge to viral eradication. Effective latency reversing agents (LRAs) based on "shock and kill" strategy are urgently needed. The natural phytoalexin resveratrol has been demonstrated to enhance HIV gene expression, although its mechanism remains unclear. In this study, we demonstrated that resveratrol was able to reactivate latent HIV without global T cell activation in vitro. Mode of action studies showed resveratrol-mediated reactivation from latency did not involve the activation of silent mating type information regulation 2 homologue 1 (SIRT1), which belonged to class-3 histone deacetylase (HDAC). However, latent HIV was reactivated by resveratrol mediated through increasing histone acetylation and activation of heat shock factor 1 (HSF1). Additionally, synergistic activation of the latent HIV reservoirs was observed under cotreatment with resveratrol and conventional LRAs. Collectively, this research reveals that resveratrol is a natural LRA and shows promise for HIV therapy.

  10. Towards a proper assignment of systemic risk: the combined roles of network topology and shock characteristics.

    Science.gov (United States)

    Loepfe, Lasse; Cabrales, Antonio; Sánchez, Angel

    2013-01-01

    The 2007-2008 financial crisis solidified the consensus among policymakers that a macro-prudential approach to regulation and supervision should be adopted. The currently preferred policy option is the regulation of capital requirements, with the main focus on combating procyclicality and on identifying the banks that have a high systemic importance, those that are "too big to fail". Here we argue that the concept of systemic risk should include the analysis of the system as a whole and we explore systematically the most important properties for policy purposes of networks topology on resistance to shocks. In a thorough study going from analytical models to empirical data, we show two sharp transitions from safe to risky regimes: 1) diversification becomes harmful with just a small fraction (~2%) of the shocks sampled from a fat tailed shock distributions and 2) when large shocks are present a critical link density exists where an effective giant cluster forms and most firms become vulnerable. This threshold depends on the network topology, especially on modularity. Firm size heterogeneity has important but diverse effects that are heavily dependent on shock characteristics. Similarly, degree heterogeneity increases vulnerability only when shocks are directed at the most connected firms. Furthermore, by studying the structure of the core of the transnational corporation network from real data, we show that its stability could be clearly increased by removing some of the links with highest centrality betweenness. Our results provide a novel insight and arguments for policy makers to focus surveillance on the connections between firms, in addition to capital requirements directed at the nodes.

  11. Reliability for systems of degrading components with distinct component shock sets

    International Nuclear Information System (INIS)

    Song, Sanling; Coit, David W.; Feng, Qianmei

    2014-01-01

    This paper studies reliability for multi-component systems subject to dependent competing risks of degradation wear and random shocks, with distinct shock sets. In practice, many systems are exposed to distinct and different types of shocks that can be categorized according to their sizes, function, affected components, etc. Previous research primarily focuses on simple systems with independent failure processes, systems with independent component time-to-failure, or components that share the same shock set or type of shocks. In our new model, we classify random shocks into different sets based on their sizes or function. Shocks with specific sizes or function can selectively affect one or more components in the system but not necessarily all components. Additionally the shocks from the different shock sets can arrive at different rates and have different relative magnitudes. Preventive maintenance (PM) optimization is conducted for the system with different component shock sets. Decision variables for two different maintenance scheduling problems, the PM replacement time interval, and the PM inspection time interval, are determined by minimizing a defined system cost rate. Sensitivity analysis is performed to provide insight into the behavior of the proposed maintenance policies. These models can be applied directly or customized for many complex systems that experience dependent competing failure processes with different component shock sets. A MEMS (Micro-electro mechanical systems) oscillator is a typical system subject to dependent and competing failure processes, and it is used as a numerical example to illustrate our new reliability and maintenance models

  12. The shock tube as wave reactor for kinetic studies and material systems

    Energy Technology Data Exchange (ETDEWEB)

    Bhaskaran, K.A. [Indian Institute of Technology, Chennai (India). Department of Mechanical Engineering; Roth, P. [Gerhard Mercator Universitat, Duisberg (Germany). Institut fur Verbrennung und Gasdynamik

    2002-07-01

    Several important reviews of shock tube kinetics have appeared earlier, prominent among them being 'Shock Tube Technique in Chemical Kinetics' by Belford and Strehlow (Ann Rev Phys Chem 20 (1969) 247), 'Chemical Reaction of Shock Waves' by Wagner (Proceedings of the Eighth International Shock Tube Symposium (1971) 4/1), 'Shock Tube and Shock Wave Research' by Bauer and Lewis (Proceedings of the 11th International Symposium on Shock Tubes and Waves (1977) 269), 'Shock Waves in Chemistry' edited by Assa Lifshitz (Shock Waves in Chemistry, 1981) and 'Shock Tube Techniques in Chemical Kinetics' by Wing Tsang and Assa Lifshitz (Annu Rev Phys Chem 41 (1990) 559). A critical analysis of the different shock tube techniques, their limitations and suggestions to improve the accuracy of the data produced are contained in these reviews. The purpose of this article is to present the current status of kinetic research with emphasis on the diagnostic techniques. Selected studies on homogeneous and dispersed systems are presented to bring out the versatility of the shock tube technique. The use of the shock tube as high temperature wave reactor for gas phase material synthesis is also highlighted. (author)

  13. Offshoring as an Exogenous Shock to the Services Production System

    DEFF Research Database (Denmark)

    Brandl, Kristin; Mol, Michael; Petersen, Bent

    Production of services involves three key elements, an output for the client, resources of a provider and task execution. Offshoring of services acts as an exogenous shock to such a production system. Using multiple case methodology we investigate how task output, execution, and resources change...... as a consequence of offshoring and particularly how these elements are realigned. The cases reveal substantial managerial challenges in the alignment process prompted by a relocation of service task execution to an emerging economy. In particular, we find that instead of some set of capabilities that proactively...

  14. Systemic release of cytokines and heat shock proteins in porcine models of polytrauma and hemorrhage

    Science.gov (United States)

    Baker, Todd A.; Romero, Jacqueline; Bach, Harold H.; Strom, Joel A.; Gamelli, Richard L.; Majetschak, Matthias

    2011-01-01

    Objective To define systemic release kinetics of a panel of cytokines and heat shock proteins (HSP) in porcine polytrauma/hemorrhage models and to evaluate whether they could be useful as early trauma biomarkers. Design and Setting Prospective study in a research laboratory. Subjects Twenty-one Yorkshire pigs. Measurements and Main Results Pigs underwent polytrauma (femur fractures/lung contusion, P), hemorrhage (mean arterial pressure 25-30mmHg, H), polytrauma plus hemorrhage (P/H) or sham procedure (S). Plasma was obtained at baseline, in 5-15min intervals during a 60min shock period without intervention and in 60-120min intervals during fluid resuscitation for up to 300min. Plasma was assayed for IL-1β, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12/IL-23p40, IL-13, IL-17, IL-18, IFNγ, TGFβ, TNFα, HSP40, HSP70 and HSP90 by ELISA. All animals after S, P and H survived (n=5/group). Three of six animals after P/H died. IL-10 increased during shock after P and this increase was attenuated after H. TNFα increased during the shock period after P, H and also after S. P/H abolished the systemic IL-10 and TNFα release and resulted in 20-30% increased levels of IL-6 during shock. As fluid resuscitation was initiated TNFα and IL-10 levels decreased after P, H and P/H, HSP 70 increased after P, IL-6 levels remained elevated after P/H and also increased after P and S. Conclusions Differential regulation of the systemic cytokine release after polytrauma and/or hemorrhage, in combination with the effects of resuscitation, can explain the variability and inconsistent association of systemic cytokine/HSP levels with clinical variables in trauma patients. Insults of major severity (P/H) partially suppress the systemic inflammatory response. The plasma concentrations of the measured cytokines/HSPs do not reflect injury severity or physiological changes in porcine trauma models and are unlikely to be able to serve as useful trauma biomarkers in patients. PMID:21983369

  15. The heat shock proteins at the increasing of the radioresistance of silkworm embryo Bombyx Moril

    International Nuclear Information System (INIS)

    Agaev, F.A.; Garibov, A.A.; Aliev, D.I.; Alieva, I.N.

    2002-01-01

    The aim of this study is revealing the role of Heat Shock Proteins (HSP) at the radio-modification effect of Heat Shock (HS) on the silkworm embryo. Our preliminary study was indicated that 3-daily silkworm embryo is more than 10-12 times sensitive to gamma-radiation in comparative to 7-daily embryo. Investigation of the HS effect on the radiosensitivity of the embryo indicates that thermal treatment (40 deg. C) of 3 daily embryo during 60 min before irradiation leads the increasing of its radioresistance. At the same time, the HS treatment immediately after irradiation capable increases strike affect of irradiation. LD 50 for heat treated embryo before and after irradiation consists of 46.7 and 19.0 Gy, correspondingly. For embryo irradiated without heat treatment LD 50 is 29.5 Gy. Identical effects are observed for 7-daily embryo. Increasing of the radioresistance by HS before irradiation, obviously, may be explained by the embryo cell reply to the stress factor and capable initiated by different biochemical shifts, for example, by induction of HPS synthesis. According to the results of carried out experiments HS treatment leads to the induction or increasing of the HSP synthesis into this embryo. Protein with molecular mass 70 kDa (HSP-70 kDa) has been synthesised de novo. The synthesis of the other two proteins (HSP-83 kDa and HSP-68 kDa) significantly increases at the high temperature. It is noted, that HSP-70 kDa consists of 55-60 % of whole included radioactive mark. Identical induction was observed in the experiments at the combined effect both HS and gamma-radiation on the embryo. At the post-radiation heat treatment the induction of HSP synthesis is observed, too. It was concluded that damages induced by irradiation can not prevent HSP induction into embryo. The result of comparative analysis was shown that in 3-daily embryo in spite of 7-daily embryo the synthesis of HSP is more intensive and correlated with the radio- modification effect of HS. The

  16. Role of the renin-angiotensin system, renal sympathetic nerve system, and oxidative stress in chronic foot shock-induced hypertension in rats.

    Science.gov (United States)

    Dong, Tao; Chen, Jing-Wei; Tian, Li-Li; Wang, Lin-Hui; Jiang, Ren-Di; Zhang, Zhe; Xu, Jian-Bing; Zhao, Xiao-Dong; Zhu, Wei; Wang, Guo-Qing; Sun, Wan-Ping; Zhang, Guo-Xing

    2015-01-01

    The renin-angiotensin system (RAS) and renal sympathetic nerve system (RSNS) are involved in the development of hypertension. The present study is designed to explore the possible roles of the RAS and the RSNS in foot shock-induced hypertension. Male Sprague-Dawley rats were divided into six groups: control, foot shock, RSNS denervation, denervation plus foot shock, Captopril (angiotensin I converting enzyme inhibitor, ACE inhibitor) plus foot shock, and Tempol (superoxide dismutase mimetic) plus foot shock. Rats received foot shock for 14 days. We measured the quantity of thiobarbituric acid reactive substances (TBARS), corticosterone, renin, and angiotensin II (Ang II) in plasma, the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and renal noradrenaline content. RAS component mRNA and protein levels were quantified in the cerebral cortex and hypothalamus. The two week foot shock treatment significantly increased systolic blood pressure, which was accompanied by an increase in angiotensinogen, renin, ACE1, and AT1a mRNA and protein expression in the cerebral cortex and hypothalamus, an increase of the plasma concentrations of renin, Ang II, corticosterone, and TBARS, as well as a decrease in plasma SOD and GSH-Px activities. Systolic blood pressure increase was suppressed by denervation of the RSNS or treatment with Captopril or Tempol. Interestingly, denervation or Tempol treatment both decreased main RAS components not only in the circulatory system, but also in the central nervous system. In addition, decreased antioxidant levels and increased TBARS and corticosterone levels were also partially restored by denervation or treatment with Tempol or Captopril. RAS, RSNS and oxidative stress reciprocally potentiate to play important roles in the development of foot shock-induced hypertension.

  17. Replacement policy in a system under shocks following a Markovian arrival process

    International Nuclear Information System (INIS)

    Montoro-Cazorla, Delia; Perez-Ocon, Rafael; Carmen Segovia, Maria del

    2009-01-01

    We present a system subject to shocks that arrive following a Markovian arrival process. The system is minimally repaired. It is replaced when a certain number of shocks arrive. A general model where the replacements are governed by a discrete phase-type distribution is studied. For this system, the Markov process governing the system is constructed, and the interarrival times between replacements and the number of replacements are calculated. A special case of this system is when it can stand a prefixed number of shocks. For this new system, the same performance measures are calculated. The systems are considered in transient and stationary regime

  18. Replacement policy in a system under shocks following a Markovian arrival process

    Energy Technology Data Exchange (ETDEWEB)

    Montoro-Cazorla, Delia [Department of Statistics and Operational Research, University of Jaen (Spain); Perez-Ocon, Rafael [Department of Statistics and Operational Research, University of Granada, Granada (Spain)], E-mail: rperezo@ugr.es; Carmen Segovia, Maria del [Departamento de Estadistica e I.O., University of Granada, Granada (Spain)

    2009-02-15

    We present a system subject to shocks that arrive following a Markovian arrival process. The system is minimally repaired. It is replaced when a certain number of shocks arrive. A general model where the replacements are governed by a discrete phase-type distribution is studied. For this system, the Markov process governing the system is constructed, and the interarrival times between replacements and the number of replacements are calculated. A special case of this system is when it can stand a prefixed number of shocks. For this new system, the same performance measures are calculated. The systems are considered in transient and stationary regime.

  19. New safety systems for better impact shock protection of pedestrians; Neue Sicherheitssysteme fuer besseren Fussgaengerschutz

    Energy Technology Data Exchange (ETDEWEB)

    Buechling, J.

    2005-06-01

    From October 2005, new vehicles in the European Union must be equipped successively with impact shock protection systems for pedestrians. There are many different concepts and solutions, from optimised front ends and flexible hoods to outside airbags, flexible shock absorbers and systems to prevent rolling over pedestrians. (orig.)

  20. Investigation of pressure transients in nuclear filtration systems: construction details of a large shock tube

    International Nuclear Information System (INIS)

    Smith, P.R.; Gregory, W.S.

    1980-04-01

    This report documents the construction of a 0.914-m (36-in.)-dia. shock tube on the New Mexico State University caompus. Highly variable low-grade explosions can be simulated with the shock tube. We plan to investigate the response of nuclear facility ventilation system components to low-grade explosions. Components of particular interest are high-capacity, high efficiency paticulate air (HEPA) filters. Shock tube construction details, operating principles, firing sequence, and preliminary results are reported

  1. Letter to the EditorForbush precursory increase and shock-associated particles on 20 October 1989

    Directory of Open Access Journals (Sweden)

    A. Struminsky

    2002-08-01

    Full Text Available Strong interplanetary disturbances may affect cosmic ray protons tremendously with energies less than 1 GeV, increasing their intensity by hundreds of percents, but they are not so effective for protons of higher energies. This energy limit is crucial to understand processes of cosmic ray propagation and acceleration in the heliosphere. The Forbush pre-increase and the effect of shock-associated particles observed on 20 October 1989 illustrate the problem. This is a rare event, when the energies of shock-associated particles measured by the GOES-7 satellite spread continuously to the neutron monitor energies. The Forbush pre-increase could be attributed to a single reflection of galactic cosmic rays from the magnetic wall observed at 12:00 UT. It had a very hard spectrum with maximum energy of modulation more than 10 GeV. The spectrum of shock-associated particles was soft and their maximum energy was less than 1 GeV. The problem of shock acceleration versus trapping is discussed for the 20 October 1989 event. It is argued that the shock-associated particles were accelerated near the flare site and then propagated to the Earth inside the trap between two magnetic walls at 12:00 UT and 17:00 UT.Key words. Interplanetary physics (cosmic rays; energetic particles; interplanetary magnetic fields

  2. Safety in pipeline systems. Prevention of pressure shocks and cavitation shocks; Sichere Rohrleitungssysteme. Vermeidung von Druckstoessen und Kavitationsschlaegen

    Energy Technology Data Exchange (ETDEWEB)

    Prasser, H.-M. [Forschungszentrum Rossendorf, Dresden (Germany); Dudlik, Andreas; Schoenfeld, Sri Budi Handajani; Apostolidis, Alexander; Schlueter, Stefan [Fraunhofer-Institut UMSICHT, Oberhausen (Germany)

    2002-06-01

    The Fraunhofer institute UMSICHT, Oberhausen, and Rossendorf research centre FZR investigated the causes and consequences of pressure shocks and cavitation shocks and ways to prevent them. The experimental set-up and software tools were made available. New methods for preventing pressure shocks and cavitation shocks were developed, and armatures were developed on this basis which are also suited for retrofitting. [German] In Rohrleitungssystemen koennen durch instationaere Stroemungsvorgaenge gefaehrliche Betriebsbedingungen entstehen, die infolge von mehrfach erhoehtem Systemdruck und von Lasteintraegen in Halterungen Mensch und Umwelt erheblich schaedigen. Je nach Industriebranche koennen unterschiedliche betriebsbedingte Ursachen zu sog. Druckstoessen, Kavitations- und Kondensationsschlaegen fuehren, z.B. Kontaktkondensation von Dampf und Wasser oder ploetzliche Aenderung der Fluessigkeitsgeschwindigkeit. Das Fraunhofer-Institut UMSICHT in Oberhausen und das Forschungszentrum Rossendorf FZR untersuchen Ursachen, Folgen und Moeglichkeiten zur Vermeidung von Druckstoessen und Kavitationsschlaegen. Hierzu stehen Versuchsanlagen unterschiedlichen Massstabs sowie Softwaretools zur Verfuegung. Aus den Forschungsergebnissen wurden neue Methoden zur Vermeidung von Druckstoessen und Kavitationsschlaegen entwickelt. Hierbei werden neue oder vorhandene Absperrarmaturen mit einem hydraulischen Bremssystem ausgeruestet und mit einer Rueckschlagklappe kombiniert angeordnet. Das System gilt auch fuer bereits existierende Anlagen als besonders geeignet, da es keine Hilfsenergie benoetigt und sich an Aenderungen der Systemparameter Druck und Fliessgeschwindigkeit selbststaendig anpasst. (orig.)

  3. Narrative theory: II. Self-generated and experimenter-provided negative income shock narratives increase delay discounting.

    Science.gov (United States)

    Mellis, Alexandra M; Snider, Sarah E; Bickel, Warren K

    2018-04-01

    Reading experimenter-provided narratives of negative income shock has been previously demonstrated to increase impulsivity, as measured by discounting of delayed rewards. We hypothesized that writing these narratives would potentiate their effects of negative income shock on decision-making more than simply reading them. In the current study, 193 cigarette-smoking individuals from Amazon Mechanical Turk were assigned to either read an experimenter-provided narrative or self-generate a narrative describing either the negative income shock of job loss or a neutral condition of job transfer. Individuals then completed a task of delay discounting and measures of affective response to narratives, as well as rating various narrative qualities such as personal relevance and vividness. Consistent with past research, narratives of negative income shock increased delay discounting compared to control narratives. No significant differences existed in delay discounting after self-generating compared to reading experimenter-provided narratives. Positive affect was lower and negative affect was higher in response to narratives of job loss, but affect measures did not differ based on whether narratives were experimenter-provided or self-generated. All narratives were rated as equally realistic, but self-generated narratives (whether negative or neutral) were rated as more vivid and relevant than experimenter-provided narratives. These results indicate that the content of negative income shock narratives, regardless of source, consistently drives short-term choices. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  4. Pre-Acting Control for Shock and Impact Isolation Systems

    Directory of Open Access Journals (Sweden)

    D.V. Balandin

    2005-01-01

    Full Text Available Pre-acting control in shock/impact isolation systems is studied. With pre-acting control, the isolation system begins to respond to an impact before this impact has been applied to the base. The limiting performance of the isolator with pre-acting control is investigated for a single-degree-of-freedom system subject to an instantaneous impact. The isolation performance index is defined as the maximum of the absolute value of the displacement of the object to be isolated relative to the base, provided that the magnitude of the control force transmitted to the object does not exceed a prescribed value. It is shown that there is a substantial advantage in the use of pre-acting isolators over isolators without pre-action. Particular attention is given to a pre-acting isolator based on a passive elastic element (a spring separating the object to be protected from the base. An example illustrates the calculation of the design parameters of such an isolator.

  5. The ways for increasing the technical capabilities of antiseismic hydraulic shock absorbers

    International Nuclear Information System (INIS)

    Kaznovskij, S.P.; Lenskij, V.S.; Plyaskov, A.S.

    1986-01-01

    Basic achievements in a sphere of production of a new type of atomic power equipment-hydraulic shock absorbers-intended for NPP antiseismic fixation of pipelines are considered in short. In designing the new shock absorbers emphasis is placed on maximum unification of the most labor-consuming units, introduction of promising technological processes for mechanical treatment, optimization of the type and dimensional series, impovement of operational characteristics and simplification of assemblying and preparation for putting into operation

  6. Mild electrical stimulation with heat stimulation increase heat shock protein 70 in articular chondrocyte.

    Science.gov (United States)

    Hiraoka, Nobuyuki; Arai, Yuji; Takahashi, Kenji A; Mazda, Osam; Kishida, Tsunao; Honjo, Kuniaki; Tsuchida, Shinji; Inoue, Hiroaki; Morino, Saori; Suico, Mary Ann; Kai, Hirofumi; Kubo, Toshikazu

    2013-06-01

    The objective of this study is to investigate the effects of mild electrical stimulation (MES) and heat stress (HS) on heat shock protein 70 (HSP70), that protects chondrocytes and enhances cartilage matrix metabolism, in chondrocyte and articular cartilage. Rabbit articular chondrocytes were treated with MES and/or HS. The safeness was assessed by LDH assay and morphology. HSP70 protein, ubiquitinated proteins and HSP70 mRNA were examined by Western blotting and real-time PCR. Rat knee joints were treated with MES and/or HS. HSP70 protein, ubiquitinated proteins, HSP70 mRNA and proteoglycan core protein (PG) mRNA in articular cartilage were investigated. In vitro, HS increased HSP70 mRNA and HSP70 protein. MES augmented ubiquitinated protein and HSP70 protein, but not HSP70 mRNA. MES + HS raised HSP70 mRNA and ubiquitinated protein, and significantly increased HSP70 protein. In vivo, HS and MES + HS treatment augmented HSP70 mRNA. HS modestly augmented HSP70 protein. MES + HS significantly increased HSP70 protein and ubiquitinated proteins. PG mRNA was markedly raised by MES + HS. This study demonstrated that MES, in combination with HS, increases HSP70 protein in chondrocytes and articular cartilage, and promotes cartilage matrix metabolism in articular cartilage. MES in combination with HS can be a novel physical therapy for osteoarthritis by inducing HSP70 in articular cartilage. Copyright © 2013 Orthopaedic Research Society.

  7. A Comprehensive Review of the Techniques on Regenerative Shock Absorber Systems

    Directory of Open Access Journals (Sweden)

    Ran Zhang

    2018-05-01

    Full Text Available In this paper, the current technologies of the regenerative shock absorber systems have been categorized and evaluated. Three drive modes of the regenerative shock absorber systems, namely the direct drive mode, the indirect drive mode and hybrid drive mode are reviewed for their readiness to be implemented. The damping performances of the three different modes are listed and compared. Electrical circuit and control algorithms have also been evaluated to maximize the power output and to deliver the premium ride comfort and handling performance. Different types of parameterized road excitations have been applied to vehicle suspension systems to investigate the performance of the regenerative shock absorbers. The potential of incorporating nonlinearity into the regenerative shock absorber design analysis is discussed. The research gaps for the comparison of the different drive modes and the nonlinearity analysis of the regenerative shock absorbers are identified and, the corresponding research questions have been proposed for future work.

  8. 'Cold shock' increases the frequency of homology directed repair gene editing in induced pluripotent stem cells.

    Science.gov (United States)

    Guo, Q; Mintier, G; Ma-Edmonds, M; Storton, D; Wang, X; Xiao, X; Kienzle, B; Zhao, D; Feder, John N

    2018-02-01

    Using CRISPR/Cas9 delivered as a RNA modality in conjunction with a lipid specifically formulated for large RNA molecules, we demonstrate that homology directed repair (HDR) rates between 20-40% can be achieved in induced pluripotent stem cells (iPSC). Furthermore, low HDR rates (between 1-20%) can be enhanced two- to ten-fold in both iPSCs and HEK293 cells by 'cold shocking' cells at 32 °C for 24-48 hours following transfection. This method can also increases the proportion of loci that have undergone complete sequence conversion across the donor sequence, or 'perfect HDR', as opposed to partial sequence conversion where nucleotides more distal to the CRISPR cut site are less efficiently incorporated ('partial HDR'). We demonstrate that the structure of the single-stranded DNA oligo donor can influence the fidelity of HDR, with oligos symmetric with respect to the CRISPR cleavage site and complementary to the target strand being more efficient at directing 'perfect HDR' compared to asymmetric non-target strand complementary oligos. Our protocol represents an efficient method for making CRISPR-mediated, specific DNA sequence changes within the genome that will facilitate the rapid generation of genetic models of human disease in iPSCs as well as other genome engineered cell lines.

  9. Mesenchymal stem cells increase T-regulatory cells and improve healing following trauma and hemorrhagic shock.

    Science.gov (United States)

    Gore, Amy V; Bible, Letitia E; Song, Kimberly; Livingston, David H; Mohr, Alicia M; Sifri, Ziad C

    2015-07-01

    Rodent lungs undergo full histologic recovery within 1 week following unilateral lung contusion (LC). However, when LC is followed by hemorrhagic shock (HS), healing is impaired. We hypothesize that the intravenous administration of mesenchymal stem cells (MSCs) in animals undergoing combined LC followed by HS (LCHS) will improve wound healing. Male Sprague-Dawley rats (n = 5-6 per group) were subjected to LCHS with or without the injection of a single intravenous dose of 5 × 10 MSCs following return of shed blood after HS. Rats were sacrificed 7 days following injury. Flow cytometry was used to determine the T-regulatory cell (Treg) population in peripheral blood. Lung histology was graded using a well-established lung injury score (LIS). Components of the LIS include average inflammatory cells per high-power field over 30 fields, interstitial edema, pulmonary edema, and alveolar integrity, with total scores ranging from 0 to 11. Data were analyzed by analysis of variance followed by Tukey's multiple comparison test, expressed as mean (SD). p healing with an LIS unchanged from naive. The addition of HS resulted in a persistently elevated LIS score, whereas the addition of MSCs to LCHS decreased the LIS score back to naive levels. The change in LIS was driven by a significant decrease in edema scores. In rats undergoing LC alone, 10.5% (3.3%) of CD4 cells were Tregs. The addition of HS caused no significant change in Treg population (9.3% [0.7%]), whereas LCHS + MSC significantly increased the population to 18.2% (6.8%) in peripheral blood (p healing following trauma and HS is improved by a single dose of MSCs given immediately after injury. This enhanced healing is associated with an increase in the Treg population and a significant decrease in lung edema score as compared with animals undergoing LCHS. Further study into the role of Tregs in MSC-mediated wound healing is warranted.

  10. A comparison of shock-cloud and wind-cloud interactions: effect of increased cloud density contrast on cloud evolution

    Science.gov (United States)

    Goldsmith, K. J. A.; Pittard, J. M.

    2018-05-01

    The similarities, or otherwise, of a shock or wind interacting with a cloud of density contrast χ = 10 were explored in a previous paper. Here, we investigate such interactions with clouds of higher density contrast. We compare the adiabatic hydrodynamic interaction of a Mach 10 shock with a spherical cloud of χ = 103 with that of a cloud embedded in a wind with identical parameters to the post-shock flow. We find that initially there are only minor morphological differences between the shock-cloud and wind-cloud interactions, compared to when χ = 10. However, once the transmitted shock exits the cloud, the development of a turbulent wake and fragmentation of the cloud differs between the two simulations. On increasing the wind Mach number, we note the development of a thin, smooth tail of cloud material, which is then disrupted by the fragmentation of the cloud core and subsequent `mass-loading' of the flow. We find that the normalized cloud mixing time (tmix) is shorter at higher χ. However, a strong Mach number dependence on tmix and the normalized cloud drag time, t_{drag}^' }, is not observed. Mach-number-dependent values of tmix and t_{drag}^' } from comparable shock-cloud interactions converge towards the Mach-number-independent time-scales of the wind-cloud simulations. We find that high χ clouds can be accelerated up to 80-90 per cent of the wind velocity and travel large distances before being significantly mixed. However, complete mixing is not achieved in our simulations and at late times the flow remains perturbed.

  11. Influenza A/H1N1 septic shock in a patient with systemic lupus erythematosus. A case report

    Directory of Open Access Journals (Sweden)

    Tselios Konstantinos

    2011-12-01

    Full Text Available Abstract Background Immunocompromised patients, such as systemic lupus erythematosus (SLE sufferers have an increased risk of mortality, following influenza infection. In the recent pandemic, influenza A H1NI virus caused 18449 deaths, mainly because of adult respiratory distress syndrome or bacterial co-infections. Case Presentation In this case report, an SLE patient with viral-induced septic shock, without overt pulmonary involvement, is discussed. The patient was administered oseltamivir and supportive treatment, including wide-spectrum antibiotics, vasopressors and steroids, according to the guidelines proposed for bacterial sepsis and septic shock. She finally survived and experienced a lupus flare soon after intensive care unit (ICU discharge. Conclusions To our knowledge, this is the first case to report severe septic shock from influenza A/H1N1 virus, without overt pulmonary involvement.

  12. Do JJ Stents Increase the Effectiveness of Extracorporeal Shock Wave Lithotripsy for Pediatric Renal Stones?

    Science.gov (United States)

    Gündüz, Metin; Sekmenli, Tamer; Ciftci, İlhan; Elmacı, Ahmet Midhat

    2017-01-01

    We aimed to evaluate the effects of preoperative urinary catheterization in nephrolithiasis treatment with extracorporeal shock wave lithotripsy (SWL). Patients admitted to the Department of Pediatric Surgery for renal stones between June 2012 and June 2014 were evaluated retrospectively. Patients were divided into 2 groups based on JJ stent placements. Group 1 did not receive JJ stents, while group 2 did. The recorded demographic data for each group included age, gender, stone size, location, sessions, and complications. The Elmed Complit ESWL system was used with 11-13 kV, and 1,000-1,200 shots in patients 2-4 years of age, and 11-14 kV, and 1,000-1,500 shots for patients over 4 years. In group 1, 18 sessions of SWL were performed on 8 female and 2 male children with a mean age of 4.5 (range 2-12) years and stone diameter of 9 (range 7-15) mm. The locations of the renal stones were in the upper pole in 1 patient, 7 in the lower pole, and 2 in the pelvis renalis. Postoperatively, 1 patient had hematuria, 2 had dysuria, and one had a stone in the external urethral meatus. Eighty percent of patients were stone free; there were no fragmentations in 2 patients, and 1 patient discontinued treatment. In group 2, 15 SWL sessions were performed on 5 female and 5 male children aged 4 (range 3-5) and the stone diameter was 9 (range 7-16) mm. The locations of the renal stones were in the upper pole in 6 patients, in the lower pole in 3 patients, and in the ureteropelvic junction in one patient. JJ stents were placed in all patients preoperatively. Postoperatively, 3 patients had hematuria and one had dysuria. At the end of the study, all of the patients were stone free. Statistically, there were no differences in age, gender, stone size, location, and the number of sessions. Our results indicate that SWL without preoperative ureteral stenting is an effective and safe procedure that can be carried out in the pediatric population. Preoperative JJ stenting is unnecessary in

  13. Nuclear fuel assembly with a shock absorber system especially for seismic shocks

    International Nuclear Information System (INIS)

    Jabsen, F.S.

    1978-01-01

    Hydraulic system for absorbing impacts imparted to fuel assemblies. Internal buffers that brace the fuel assemblies so as to restrain their longitudinal displacement, rest against mobile spring buffers. Some of these spring buffers have plungers sliding in hollow tubular guide uprights provided with longitudinal slots. The end of each upright is closed by a plate fitted with an orifice. When an earthquake forces the plunger and spring buffer assemblies to move, the water under pressure in the upright guide tubes stop this movement. This water, which gushes from the holes in the plates, enables the displacement to take place at a controlled rate at which the forces applied are absorbed in complete safety. The plungers gradually close up the slots in the guide uprights, thereby progressively reducing the section through which the water inside the guide upright can flow out. The resistance increases progressively and protects the structure of the reactor core [fr

  14. Numerical simulation of increasing initial perturbations of a bubble in the bubble–shock interaction problem

    Energy Technology Data Exchange (ETDEWEB)

    Korneev, Boris [Moscow Institute of Physics and Technology, 9 Institutsky lane, Dolgoprudny 141700 (Russian Federation); Levchenko, Vadim, E-mail: boris.korneev@phystech.edu [Keldysh Institute of Applied Mathematics, 4 Miusskaya square, Moscow 125047 (Russian Federation)

    2016-12-15

    A set of numerical experiments on the interaction between a planar shock wave and a spherical bubble with a slightly perturbed surface is considered. Spectral analysis of the instability growth is carried out and three-dimensional Euler equations of fluid dynamics are chosen as the mathematical model for the process. The equations are solved via the Runge–Kutta discontinuous Galerkin method and the special DiamondTorre algorithm for multi-GPU implementation is used. (paper)

  15. Systemic Inflammatory Effects of Traumatic Brain Injury, Femur Fracture, and Shock: An Experimental Murine Polytrauma Model

    Directory of Open Access Journals (Sweden)

    C. Probst

    2012-01-01

    Full Text Available Objective. Despite broad research in neurotrauma and shock, little is known on systemic inflammatory effects of the clinically most relevant combined polytrauma. Experimental investigation in an animal model may provide relevant insight for therapeutic strategies. We describe the effects of a combined injury with respect to lymphocyte population and cytokine activation. Methods. 45 male C57BL/6J mice (mean weight 27 g were anesthetized with ketamine/xylazine. Animals were subjected to a weight drop closed traumatic brain injury (WD-TBI, a femoral fracture and hemorrhagic shock (FX-SH. Animals were subdivided into WD-TBI, FX-SH and combined trauma (CO-TX groups. Subjects were sacrificed at 96 h. Blood was analysed for cytokines and by flow cytometry for lymphocyte populations. Results. Mortality was 8%, 13% and 47% for FX-SH, WD-TBI and CO-TX groups (P<0.05. TNFα (11/13/139 for FX-SH/WD-TBI/CO-TX; P<0.05, CCL2 (78/96/227; P<0.05 and IL-6 (16/48/281; P=0.05 showed significant increases in the CO-TX group. Lymphocyte populations results for FX-SH, WD-TBI and CO-TX were: CD-4 (31/21/22; P= n.s., CD-8 (7/28/34, P<0.05, CD-4-CD-8 (11/12/18; P= n.s., CD-56 (36/7/8; P<0.05. Conclusion. This study shows that a combination of closed TBI and femur-fracture/ shock results in an increase of the humoral inflammation. More attention to combined injury models in inflammation research is indicated.

  16. Laboratory studies of stagnating plasma flows with applications to inner solar system and stellar bow shocks

    Science.gov (United States)

    Weber, T. E.; Smith, R. J.; Hsu, S. C.

    2016-10-01

    Supercritical magnetized collisionless shocks are thought to play a dominant role in the overall partition of energy throughout the universe by converting flow kinetic energy to other forms such as thermal and supra-thermal populations, magnetic field enhancement, turbulence, and energetic particles. The Magnetized Shock Experiment (MSX) at LANL creates conditions similar to those of inner solar system and stellar bow shocks by accelerating hot (100s of eV during translation) dense (1022 - 1023 m-3) Field Reversed Configuration (FRC) plasmoids to 100s of km/s; resulting in β 1, collisionless plasma flows with Msonic and MAlfvén 10. The drifting FRC can be made to impinge upon a variety of static obstacles including: a strong mirror or cusp magnetic field (mimicking magnetically excited shocks such as the Earth's bow shock), plasma pileup from a solid obstacle (similar to the bow shocks of Mercury and the Moon), and a neural gas puff (bow shocks of Venus or the comets). Characteristic shock length and time scales that are both large enough to observe yet small enough to fit within the experiment, enabling study of the complex interplay of kinetic and fluid processes that mediate cosmic shocks and can generate non-thermal distributions, produce density and magnetic field enhancements much greater than predicted by fluid theory, and accelerate particles. An overview of the experimental program will be presented, including recent results. This work is supported by the U.S. DOE, Office of Science, Office of Fusion Energy Sciences under Contract No. DE-AC52-06NA25369.

  17. Reliability assessment of competing risks with generalized mixed shock models

    International Nuclear Information System (INIS)

    Rafiee, Koosha; Feng, Qianmei; Coit, David W.

    2017-01-01

    This paper investigates reliability modeling for systems subject to dependent competing risks considering the impact from a new generalized mixed shock model. Two dependent competing risks are soft failure due to a degradation process, and hard failure due to random shocks. The shock process contains fatal shocks that can cause hard failure instantaneously, and nonfatal shocks that impact the system in three different ways: 1) damaging the unit by immediately increasing the degradation level, 2) speeding up the deterioration by accelerating the degradation rate, and 3) weakening the unit strength by reducing the hard failure threshold. While the first impact from nonfatal shocks comes from each individual shock, the other two impacts are realized when the condition for a new generalized mixed shock model is satisfied. Unlike most existing mixed shock models that consider a combination of two shock patterns, our new generalized mixed shock model includes three classic shock patterns. According to the proposed generalized mixed shock model, the degradation rate and the hard failure threshold can simultaneously shift multiple times, whenever the condition for one of these three shock patterns is satisfied. An example using micro-electro-mechanical systems devices illustrates the effectiveness of the proposed approach with sensitivity analysis. - Highlights: • A rich reliability model for systems subject to dependent failures is proposed. • The degradation rate and the hard failure threshold can shift simultaneously. • The shift is triggered by a new generalized mixed shock model. • The shift can occur multiple times under the generalized mixed shock model.

  18. Interfacial instability induced by a shock wave in a gas-liquid horizontal stratified system

    International Nuclear Information System (INIS)

    Sutradhar, S.C.; Chang, J.S.; Yoshida, H.

    1987-01-01

    The experiments are performed in a rectangular lucite duct equipped with the facility of generating shock waves. Piezo-type pressure transducers are used to monitor the strength and propagation velocity of the shock wave. As the liquid phase has high sound velocity, a prepulse wave system of flow amplitude travels in this phase at a speed faster than the principal shock wave. The magnitude of the transmitted wave in the liquid phase is estimated using a transmission coefficient for gas-liquid system. From the initial pressure ratio of the shock wave, the amplitude of the prepulse as well as the induced interfacial fluid velocity are calculated. The wave length and height of the ripples during the passage of the shock wave are estimated for a specific strength of shock wave moving through the phases. From the high speed photographs, the wave length of the ripples can be assessed. The interfacial friction factor is calculated using colebrook's equation for high speed flow. At least five distinct phenomena are observed to exist during the propagation of a shock wave. These are - (1) the energy carried by the pre-pulse is utilized in perturbing the interface; (2) shock wave induces a mass velocity at the interface; (3) the wavelength of the ripples at the interface is the product of induced interfacial mass velocity and the time period of the prepulse; (4) a portion of the liquid mass of the perturbed interface is entrained in the gas phase may be due to the hydrodynamic lift in that phase; and finally (5) waves with long wavelength are established at the interface

  19. Shocks in coupled socio-ecological systems: what are they and how can we model them?

    NARCIS (Netherlands)

    Filatova, Tatiana; Polhill, Gary; Seppelt, R.; Voinov, A.A.; Lange, S.; Bankamp, D.

    2012-01-01

    Coupled socio-ecological systems (SES) are complex systems characterized by self-organization, non-linearities, interactions among heterogeneous elements within each subsystem, and feedbacks across scales and among subsystems. When such a system experiences a shock or a crisis, the consequences are

  20. Non-lethal heat shock increased Hsp70 and immune protein transcripts but not Vibrio tolerance in the white-leg shrimp.

    Directory of Open Access Journals (Sweden)

    Nguyen Hong Loc

    Full Text Available Non-lethal heat shock boosts bacterial and viral disease tolerance in shrimp, possibly due to increases in endogenous heat shock protein 70 (Hsp70 and/or immune proteins. To further understand the mechanisms protecting shrimp against infection, Hsp70 and the mRNAs encoding the immune-related proteins prophenoloxidase (proPO, peroxinectin, penaeidin, crustin and hemocyanin were studied in post-larvae of the white-leg shrimp Litopenaeus vannamei, following a non-lethal heat shock. As indicated by RT-qPCR, a 30 min abrupt heat shock increased Hsp70 mRNA in comparison to non-heated animals. Immunoprobing of western blots and quantification by ELISA revealed that Hsp70 production after heat shock was correlated with enhanced Hsp70 mRNA. proPO and hemocyanin mRNA levels were augmented, whereas peroxinectin and crustin mRNA levels were unchanged following non-lethal heat shock. Penaeidin mRNA was decreased by all heat shock treatments. Thirty min abrupt heat shock failed to improve survival of post-larvae in a standardized challenge test with Vibrio harveyi, indicating that under the conditions of this study, L. vannamei tolerance to Vibrio infection was influenced neither by Hsp70 accumulation nor the changes in the immune-related proteins, observations dissimilar to other shrimp species examined.

  1. Non-Lethal Heat Shock Increased Hsp70 and Immune Protein Transcripts but Not Vibrio Tolerance in the White-Leg Shrimp

    Science.gov (United States)

    Loc, Nguyen Hong; MacRae, Thomas H.; Musa, Najiah; Bin Abdullah, Muhd Danish Daniel; Abdul Wahid, Mohd. Effendy; Sung, Yeong Yik

    2013-01-01

    Non-lethal heat shock boosts bacterial and viral disease tolerance in shrimp, possibly due to increases in endogenous heat shock protein 70 (Hsp70) and/or immune proteins. To further understand the mechanisms protecting shrimp against infection, Hsp70 and the mRNAs encoding the immune-related proteins prophenoloxidase (proPO), peroxinectin, penaeidin, crustin and hemocyanin were studied in post-larvae of the white-leg shrimp Litopenaeus vannamei, following a non-lethal heat shock. As indicated by RT-qPCR, a 30 min abrupt heat shock increased Hsp70 mRNA in comparison to non-heated animals. Immunoprobing of western blots and quantification by ELISA revealed that Hsp70 production after heat shock was correlated with enhanced Hsp70 mRNA. proPO and hemocyanin mRNA levels were augmented, whereas peroxinectin and crustin mRNA levels were unchanged following non-lethal heat shock. Penaeidin mRNA was decreased by all heat shock treatments. Thirty min abrupt heat shock failed to improve survival of post-larvae in a standardized challenge test with Vibrio harveyi, indicating that under the conditions of this study, L. vannamei tolerance to Vibrio infection was influenced neither by Hsp70 accumulation nor the changes in the immune-related proteins, observations dissimilar to other shrimp species examined. PMID:24039886

  2. Molecular Stress-inducing Compounds Increase Osteoclast Formation in a Heat Shock Factor 1 Protein-dependent Manner*

    Science.gov (United States)

    Chai, Ryan C.; Kouspou, Michelle M.; Lang, Benjamin J.; Nguyen, Chau H.; van der Kraan, A. Gabrielle J.; Vieusseux, Jessica L.; Lim, Reece C.; Gillespie, Matthew T.; Benjamin, Ivor J.; Quinn, Julian M. W.; Price, John T.

    2014-01-01

    Many anticancer therapeutic agents cause bone loss, which increases the risk of fractures that severely reduce quality of life. Thus, in drug development, it is critical to identify and understand such effects. Anticancer therapeutic and HSP90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin (17-AAG) causes bone loss by increasing osteoclast formation, but the mechanism underlying this is not understood. 17-AAG activates heat shock factor 1 (Hsf1), the master transcriptional regulator of heat shock/cell stress responses, which may be involved in this negative action of 17-AAG upon bone. Using mouse bone marrow and RAW264.7 osteoclast differentiation models we found that HSP90 inhibitors that induced a heat shock response also enhanced osteoclast formation, whereas HSP90 inhibitors that did not (including coumermycin A1 and novobiocin) did not affect osteoclast formation. Pharmacological inhibition or shRNAmir knockdown of Hsf1 in RAW264.7 cells as well as the use of Hsf1 null mouse bone marrow cells demonstrated that 17-AAG-enhanced osteoclast formation was Hsf1-dependent. Moreover, ectopic overexpression of Hsf1 enhanced 17-AAG effects upon osteoclast formation. Consistent with these findings, protein levels of the essential osteoclast transcription factor microphthalmia-associated transcription factor were increased by 17-AAG in an Hsf1-dependent manner. In addition to HSP90 inhibitors, we also identified that other agents that induced cellular stress, such as ethanol, doxorubicin, and methotrexate, also directly increased osteoclast formation, potentially in an Hsf1-dependent manner. These results, therefore, indicate that cellular stress can enhance osteoclast differentiation via Hsf1-dependent mechanisms and may significantly contribute to pathological and therapeutic related bone loss. PMID:24692538

  3. Molecular stress-inducing compounds increase osteoclast formation in a heat shock factor 1 protein-dependent manner.

    Science.gov (United States)

    Chai, Ryan C; Kouspou, Michelle M; Lang, Benjamin J; Nguyen, Chau H; van der Kraan, A Gabrielle J; Vieusseux, Jessica L; Lim, Reece C; Gillespie, Matthew T; Benjamin, Ivor J; Quinn, Julian M W; Price, John T

    2014-05-09

    Many anticancer therapeutic agents cause bone loss, which increases the risk of fractures that severely reduce quality of life. Thus, in drug development, it is critical to identify and understand such effects. Anticancer therapeutic and HSP90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin (17-AAG) causes bone loss by increasing osteoclast formation, but the mechanism underlying this is not understood. 17-AAG activates heat shock factor 1 (Hsf1), the master transcriptional regulator of heat shock/cell stress responses, which may be involved in this negative action of 17-AAG upon bone. Using mouse bone marrow and RAW264.7 osteoclast differentiation models we found that HSP90 inhibitors that induced a heat shock response also enhanced osteoclast formation, whereas HSP90 inhibitors that did not (including coumermycin A1 and novobiocin) did not affect osteoclast formation. Pharmacological inhibition or shRNAmir knockdown of Hsf1 in RAW264.7 cells as well as the use of Hsf1 null mouse bone marrow cells demonstrated that 17-AAG-enhanced osteoclast formation was Hsf1-dependent. Moreover, ectopic overexpression of Hsf1 enhanced 17-AAG effects upon osteoclast formation. Consistent with these findings, protein levels of the essential osteoclast transcription factor microphthalmia-associated transcription factor were increased by 17-AAG in an Hsf1-dependent manner. In addition to HSP90 inhibitors, we also identified that other agents that induced cellular stress, such as ethanol, doxorubicin, and methotrexate, also directly increased osteoclast formation, potentially in an Hsf1-dependent manner. These results, therefore, indicate that cellular stress can enhance osteoclast differentiation via Hsf1-dependent mechanisms and may significantly contribute to pathological and therapeutic related bone loss.

  4. A new shock wave assisted wood preservative injection system

    Science.gov (United States)

    Rao, K. S.; Ravikumar, G.; Lai, Ram; Jagadeesh, G.

    Preservative treatment of many tropical hard woods and bamboo pose severe problem. A number of wood preservatives (chemical formulations toxic to wood decay/ destroying organisms like fungi, wood destroying termites, marine borers etc.) and wood impregnating techniques are currently in use for improving bio resistance of timber and bamboo and thereby enhancing service life for different end uses. How ever, some species of tropical hardwoods and many species of bamboo are difficult to treat, posing technical problems. In this paper we report preliminary results of treatment of bamboo with a novel Shockwave assisted injection treatment. Samples (30×2.5×1.00 cm) of an Indian species of bamboo Dendrocalamus strictus prepared from defect free culms of dry bamboo are placed in the driven section of a vertical shock tube filled with the 4Coppepr-Chrome-Arsenic(CCA) preservative solution.The bamboo samples are subjected to repeated shock wave loading (3 shots) with typical over pressures of 30 bar. The results from the study indicate excellent penetration and retention of CCA preservative in bamboo samples. The method itself is much faster compared to the conventional methods like pressure treatment or hot and cold process.

  5. An increase in mean platelet volume from baseline is associated with mortality in patients with severe sepsis or septic shock.

    Directory of Open Access Journals (Sweden)

    Chan Ho Kim

    Full Text Available Mean platelet volume (MPV is suggested as an index of inflammation, disease activity, and anti-inflammatory treatment efficacy in chronic inflammatory disorders; however, the effect of MPV on sepsis mortality remains unclear. Therefore, we investigated whether the change in MPV between hospital admission and 72 hours (ΔMPV72h-adm predicts 28-day mortality in severe sepsis and/or septic shock.We prospectively enrolled 345 patients admitted to the emergency department (ED who received standardized resuscitation (early goal-directed therapy for severe sepsis and/or septic shock between November 2007 and December 2011. Changes in platelet indices, including ΔMPV72h-adm, were compared between survivors and non-survivors by linear mixed model analysis. The prognostic value of ΔMPV72h-adm for 28-day mortality was ascertained by Cox proportional hazards model analysis.Thirty-five (10.1% patients died within 28 days after ED admission. MPV increased significantly during the first 72 hours in non-survivors (P = 0.001 and survivors (P < 0.001; however, the rate of MPV increase was significantly higher in non-survivors (P = 0.003. Nonetheless, the difference in the platelet decline rate over the first 72 hours did not differ significantly between groups (P = 0.360. In multivariate analysis, ΔMPV72h-adm was an independent predictor of 28-day mortality, after adjusting for plausible confounders (hazard ratio, 1.44; 95% confidence interval, 1.01-2.06; P = 0.044.An increase in MPV during the first 72 hours of hospitalization is an independent risk factor for adverse clinical outcomes. Therefore, continuous monitoring of MPV may be useful to stratify mortality risk in patients with severe sepsis and/or septic shock.

  6. A mechanical analysis of woodpecker drumming and its application to shock-absorbing systems

    International Nuclear Information System (INIS)

    Yoon, Sang-Hee; Park, Sungmin

    2011-01-01

    A woodpecker is known to drum the hard woody surface of a tree at a rate of 18 to 22 times per second with a deceleration of 1200 g, yet with no sign of blackout or brain damage. As a model in nature, a woodpecker is studied to find clues to develop a shock-absorbing system for micromachined devices. Its advanced shock-absorbing mechanism, which cannot be explained merely by allometric scaling, is analyzed in terms of endoskeletal structures. In this analysis, the head structures (beak, hyoid, spongy bone, and skull bone with cerebrospinal fluid) of the golden-fronted woodpecker, Melanerpes aurifrons, are explored with x-ray computed tomography images, and their shock-absorbing mechanism is analyzed with a mechanical vibration model and an empirical method. Based on these analyses, a new shock-absorbing system is designed to protect commercial micromachined devices from unwanted high-g and high-frequency mechanical excitations. The new shock-absorbing system consists of close-packed microglasses within two metal enclosures and a viscoelastic layer fastened by steel bolts, which are biologically inspired from a spongy bone contained within a skull bone encompassed with the hyoid of a woodpecker. In the experimental characterizations using a 60 mm smoothbore air-gun, this bio-inspired shock-absorbing system shows a failure rate of 0.7% for the commercial micromachined devices at 60 000 g, whereas a conventional hard-resin method yields a failure rate of 26.4%, thus verifying remarkable improvement in the g-force tolerance of the commercial micromachined devices.

  7. Reliability Analysis of a Cold Standby System with Imperfect Repair and under Poisson Shocks

    Directory of Open Access Journals (Sweden)

    Yutian Chen

    2014-01-01

    Full Text Available This paper considers the reliability analysis of a two-component cold standby system with a repairman who may have vacation. The system may fail due to intrinsic factors like aging or deteriorating, or external factors such as Poisson shocks. The arrival time of the shocks follows a Poisson process with the intensity λ>0. Whenever the magnitude of a shock is larger than the prespecified threshold of the operating component, the operating component will fail. The paper assumes that the intrinsic lifetime and the repair time on the component are an extended Poisson process, the magnitude of the shock and the threshold of the operating component are nonnegative random variables, and the vacation time of the repairman obeys the general continuous probability distribution. By using the vector Markov process theory, the supplementary variable method, Laplace transform, and Tauberian theory, the paper derives a number of reliability indices: system availability, system reliability, the rate of occurrence of the system failure, and the mean time to the first failure of the system. Finally, a numerical example is given to validate the derived indices.

  8. Shock and vibration protection of submerged jet impingement cooling systems: Theory and experiment

    International Nuclear Information System (INIS)

    Haji Hosseinloo, Ashkan; Tan, Siow Pin; Yap, Fook Fah; Toh, Kok Chuan

    2014-01-01

    In the recent years, advances in high power density electronics and computing systems have pushed towards more advanced thermal management technologies and higher-capacity cooling systems. Among different types of cooling systems, jet impingement technology has gained attention and been widely used in different industries for its adaptability, cooling uniformity, large heat capacity, and ease of its localization. However, these cooling systems may not function properly in dynamically harsh environment inherent in many applications such as land, sea and air transportation. In this research article, a novel double-chamber jet impingement cooling system is fabricated and its performance is studied in harsh environment. Using the authors' previous studies, isolators with optimum properties are selected to ruggedize the chassis containing the cooling chamber against shock and random vibration. Experiments are conducted on both hard-mounted and isolated chassis and the cooling performance of the system is assessed using the inlet, and impingement surface temperatures of the cooling chamber. The experimental results show the isolation system prevents any failure that otherwise would occur, and also does not compromise the thermal performance of the system. - Highlights: • A novel double-chamber jet impingement cooling system was designed and fabricated. • Comprehensive set of random vibration and shock tests are conducted. • The isolation system proved to protect the cooling system properly against mechanical failure. • Cooling system performance was not significantly affected by the input random vibration and shock

  9. Numerical simulation of shock absorbers heat load for semi-active vehicle suspension system

    Directory of Open Access Journals (Sweden)

    Demić Miroslav D.

    2016-01-01

    Full Text Available Dynamic simulation, based on modelling, has a significant role during to the process of vehicle development. It is especially important in the first design stages, when relevant parameters are to be defined. Shock absorber, as an executive part of a semi-active suspension system, is exposed to thermal loads which can lead to its damage and degradation of characteristics. Therefore, this paper attempts to analyze a conversion of mechanical work into heat energy by use of a method of dynamic simulation. The issue of heat dissipation from the shock absorber has not been taken into consideration.

  10. Deficiency of heat shock transcription factor 1 suppresses heat stress-associated increase in slow soleus muscle mass of mice.

    Science.gov (United States)

    Ohno, Y; Egawa, T; Yokoyama, S; Nakai, A; Sugiura, T; Ohira, Y; Yoshioka, T; Goto, K

    2015-12-01

    Effects of heat shock transcription factor 1 (HSF1) deficiency on heat stress-associated increase in slow soleus muscle mass of mice were investigated. Both HSF1-null and wild-type mice were randomly assigned to control and heat-stressed groups. Mice in heat-stressed group were exposed to heat stress (41 °C for 60 min) in an incubator without anaesthesia. Significant increase in wet and dry weights, and protein content of soleus muscle in wild-type mice was observed seven days after the application of the heat stress. However, heat stress had no impact on soleus muscle mass in HSF1-null mice. Neither type of mice exhibited much effect of heat stress on HSF mRNA expression (HSF1, HSF2 and HSF4). On the other hand, heat stress upregulated heat shock proteins (HSPs) at the mRNA (HSP72) and protein (HSP72 and HSP110) levels in wild-type mice, but not in HSF1-null mice. The population of Pax7-positive nuclei relative to total myonuclei of soleus muscle in wild-type mice was significantly increased by heat stress, but not in HSF1-null mice. Furthermore, the absence of HSF1 gene suppressed heat stress-associated phosphorylation of Akt and p70 S6 kinase (p-p70S6K) in soleus muscle. Heat stress-associated increase in skeletal muscle mass may be induced by HSF1 and/or HSF1-mediated stress response that activates muscle satellite cells and Akt/p70S6K signalling pathway. © 2015 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.

  11. Noninvasive optoacoustic system for rapid diagnosis and management of circulatory shock

    Science.gov (United States)

    Petrov, Irene Y.; Kinsky, Michael; Petrov, Yuriy; Petrov, Andrey; Henkel, S. N.; Seeton, Roger; Esenaliev, Rinat O.; Prough, Donald S.

    2013-03-01

    Circulatory shock can lead to death or severe complications, if not promptly diagnosed and effectively treated. Typically, diagnosis and management of circulatory shock are guided by blood pressure and heart rate. However, these variables have poor specificity, sensitivity, and predictive value. Early goal-directed therapy in septic shock patients, using central venous catheterization (CVC), reduced mortality from 46.5% to 30%. However, CVC is invasive and complication-prone. We proposed to use an optoacoustic technique for noninvasive, rapid assessment of peripheral and central venous oxygenation. In this work we used a medical grade optoacoustic system for noninvasive, ultrasound image-guided measurement of central and peripheral venous oxygenation. Venous oxygenation during shock declines more rapidly in the periphery than centrally. Ultrasound imaging of the axillary [peripheral] and internal jugular vein [central] was performed using the Vivid e (GE Healthcare). We built an optoacoustic interface incorporating an optoacoustic transducer and a standard ultrasound imaging probe. Central and peripheral venous oxygenations were measured continuously in healthy volunteers. To simulate shock-induced changes in central and peripheral oxygenation, we induced peripheral vasoconstriction in the upper extremity by using a cooling blanket. Central and peripheral venous oxygenations were measured before (baseline) and after cooling and after rewarming. During the entire experiment, central venous oxygenation was relatively stable, while peripheral venous oxygenation decreased by 5-10% due to cooling and recovered after rewarming. The obtained data indicate that noninvasive, optoacoustic measurements of central and peripheral venous oxygenation may be used for diagnosis and management of circulatory shock with high sensitivity and specificity.

  12. Over-the-road shock and vibration testing of the radioisotope thermoelectric generator transportation system

    International Nuclear Information System (INIS)

    Becker, D.L.

    1997-01-01

    Radioisotope Thermoelectric Generators (RTG) convert heat generated by radioactive decay into electricity through the use of thermocouples. The RTGs have a long operating life, are reasonably lightweight, and require little or no maintenance, which make them particularly attractive for use in spacecraft. However, because RTGs contain significant quantities of radioactive materials, normally plutonium-238 and its decay products, they must be transported in packages built in accordance with Title 10, Code of Federal Regulations, Part 71 (10 CFR 71). To meet these regulations, a RTG Transportation System (RTGTS) that fully complies with 10 CFR 71 has been developed, which protects RTGs from adverse environmental conditions during normal conditions of transport (e.g., shock, vibration, and heat). To ensure the protection of RTGs from shock and vibration loadings during transport, extensive over-the-road testing was conducted on the RTG'S to obtain real-time recordings of accelerations of the air-ride suspension system trailer floor, packaging, and support structure. This paper provides an overview of the RTG'S, a discussion of the shock and vibration testing, and a comparison of the test results to the specified shock response spectra and power spectral density acceleration criteria

  13. Increased expression of heat shock protein 70 and heat shock factor 1 in chronic dermal ulcer tissues treated with laser-aided therapy.

    Science.gov (United States)

    Zhou, Jian-da; Luo, Cheng-qun; Xie, Hui-qing; Nie, Xin-min; Zhao, Yan-zhong; Wang, Shao-hua; Xu, Yi; Pokharel, Pashupati Babu; Xu, Dan

    2008-07-20

    Chronic dermal ulcers are also referred to as refractory ulcers. This study was conducted to elucidate the therapeutic effect of laser on chronic dermal ulcers and the induced expression of heat shock factor 1 (HSF1) and heat shock protein 70 (HSP70) in wound tissues. Sixty patients with 84 chronic dermal ulcers were randomly divided into traditional therapy and laser therapy groups. Laser treatment was performed in addition to traditional therapy in the laser therapy group. The treatment efficacy was evaluated after three weeks. Five tissue sections of healing wounds were randomly collected along with five normal skin sections as controls. HSP70-positive cells from HSP70 immunohistochemical staining were counted and the gray scale of positive cells was measured for statistical analysis. Reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting were performed to determine the mRNA and protein expressions of HSF1 and HSP70. The cure rate of the wounds and the total efficacy in the laser therapy group were significantly higher than those in the traditional therapy group (P ulcers plays a facilitating role in healing due to the mechanism of laser-activated endogenous heat shock protection in cells in wound surfaces.

  14. Module-based analysis of robustness tradeoffs in the heat shock response system.

    Directory of Open Access Journals (Sweden)

    Hiroyuki Kurata

    2006-07-01

    Full Text Available Biological systems have evolved complex regulatory mechanisms, even in situations where much simpler designs seem to be sufficient for generating nominal functionality. Using module-based analysis coupled with rigorous mathematical comparisons, we propose that in analogy to control engineering architectures, the complexity of cellular systems and the presence of hierarchical modular structures can be attributed to the necessity of achieving robustness. We employ the Escherichia coli heat shock response system, a strongly conserved cellular mechanism, as an example to explore the design principles of such modular architectures. In the heat shock response system, the sigma-factor sigma32 is a central regulator that integrates multiple feedforward and feedback modules. Each of these modules provides a different type of robustness with its inherent tradeoffs in terms of transient response and efficiency. We demonstrate how the overall architecture of the system balances such tradeoffs. An extensive mathematical exploration nevertheless points to the existence of an array of alternative strategies for the existing heat shock response that could exhibit similar behavior. We therefore deduce that the evolutionary constraints facing the system might have steered its architecture toward one of many robustly functional solutions.

  15. Predicting traffic volumes and estimating the effects of shocks in massive transportation systems.

    Science.gov (United States)

    Silva, Ricardo; Kang, Soong Moon; Airoldi, Edoardo M

    2015-05-05

    Public transportation systems are an essential component of major cities. The widespread use of smart cards for automated fare collection in these systems offers a unique opportunity to understand passenger behavior at a massive scale. In this study, we use network-wide data obtained from smart cards in the London transport system to predict future traffic volumes, and to estimate the effects of disruptions due to unplanned closures of stations or lines. Disruptions, or shocks, force passengers to make different decisions concerning which stations to enter or exit. We describe how these changes in passenger behavior lead to possible overcrowding and model how stations will be affected by given disruptions. This information can then be used to mitigate the effects of these shocks because transport authorities may prepare in advance alternative solutions such as additional buses near the most affected stations. We describe statistical methods that leverage the large amount of smart-card data collected under the natural state of the system, where no shocks take place, as variables that are indicative of behavior under disruptions. We find that features extracted from the natural regime data can be successfully exploited to describe different disruption regimes, and that our framework can be used as a general tool for any similar complex transportation system.

  16. Consideration of Optimal Input on Semi-Active Shock Control System

    Science.gov (United States)

    Kawashima, Takeshi

    In press working, unidirectional transmission of mechanical energy is expected in order to maximize the life of the dies. To realize this transmission, the author has developed a shock control system based on the sliding mode control technique. The controller makes a collision-receiving object effectively deform plastically by adjusting the force of the actuator inserted between the colliding objects, while the deformation of the colliding object is held at the necessity minimum. However, the actuator has to generate a large force corresponding to the impulsive force. Therefore, development of such an actuator is a formidable challenge. The author has proposed a semi-active shock control system in which the impulsive force is adjusted by a brake mechanism, although the system exhibits inferior performance. Thus, the author has also designed an actuator using a friction device for semi-active shock control, and proposed an active seatbelt system as an application. The effectiveness has been confirmed by a numerical simulation and model experiment. In this study, the optimal deformation change of the colliding object is theoretically examined in the case that the collision-receiving object has perfect plasticity and the colliding object has perfect elasticity. As a result, the optimal input condition is obtained so that the ratio of the maximum deformation of the collision-receiving object to the maximum deformation of the colliding object becomes the maximum. Additionally, the energy balance is examined.

  17. Magnetogasdynamics shock waves in a rotational axisymmetric non-ideal gas with increasing energy and conductive and radiative heat-fluxes

    Science.gov (United States)

    Nath, Gorakh

    2016-07-01

    Self-similar solutions are obtained for one-dimensional adiabatic flow behind a magnetogasdynamics cylindrical shock wave propagating in a rotational axisymmetric non ideal gas with increasing energy and conductive and radiative heat fluxes in presence of an azimuthal magnetic field. The fluid velocities and the azimuthal magnetic field in the ambient medium are assume to be varying and obeying power laws. In order to find the similarity solutions the angular velocity of the ambient medium is taken to be decreasing as the distance from the axis increases. The heat conduction is expressed in terms of Fourier's law and the radiation is considered to be the diffusion type for an optically thick grey gas model. The thermal conductivity and the absorption coefficient are assumed to vary with temperature and density. The effects of the presence of radiation and conduction, the non-idealness of the gas and the magnetic field on the shock propagation and the flow behind the shock are investigated.

  18. Hormone replacement therapy increases levels of antibodies against heat shock protein 65 and certain species of oxidized low density lipoprotein

    Directory of Open Access Journals (Sweden)

    Uint L.

    2003-01-01

    Full Text Available Hormone replacement therapy (HRT reduces cardiovascular risks, although the initiation of therapy may be associated with transient adverse ischemic and thrombotic events. Antibodies against heat shock protein (Hsp and oxidized low density lipoprotein (LDL have been found in atherosclerotic lesions and plasma of patients with coronary artery disease and may play an important role in the pathogenesis of atherosclerosis. The aim of the present study was to assess the effects of HRT on the immune response by measuring plasma levels of antibodies against Hsp 65 and LDL with a low and high degree of copper-mediated oxidative modification of 20 postmenopausal women before and 90 days after receiving orally 0.625 mg equine conjugate estrogen plus 2.5 mg medroxyprogesterone acetate per day. HRT significantly increased antibodies against Hsp 65 (0.316 ± 0.03 vs 0.558 ± 0.11 and against LDL with a low degree of oxidative modification (0.100 ± 0.01 vs 0.217 ± 0.02 (P<0.05 and P<0.001, respectively, ANOVA. The hormone-mediated immune response may trigger an inflammatory response within the vessel wall and potentially increase plaque burden. Whether or not this immune response is temporary or sustained and deleterious requires further investigation.

  19. Study on coupled shock absorber system using four electromagnetic dampers

    International Nuclear Information System (INIS)

    Fukumori, Y; Hayashi, R; Okano, H; Suda, Y; Nakano, K

    2016-01-01

    Recently, the electromagnetic damper, which is composed of an electric motor, a ball screw, and a nut, was proposed. The electromagnetic damper has high responsiveness, controllability, and energy saving performance. It has been reported that it improved ride comfort and drivability. In addition, the authors have proposed a coupling method of two electromagnetic dampers. The method enables the characteristics of bouncing and rolling or pitching motion of a vehicle to be tuned independently. In this study, the authors increase the number of coupling of electromagnetic dampers from two to four, and propose a method to couple four electromagnetic dampers. The proposed method enables the characteristics of bouncing, rolling and pitching motion of a vehicle to be tuned independently. Basic experiments using proposed circuit and motors and numerical simulations of an automobile equipped with the proposed coupling electromagnetic damper are carried out. The results indicate the proposed method is effective. (paper)

  20. Increase of Organization in Complex Systems

    OpenAIRE

    Georgiev, Georgi Yordanov; Daly, Michael; Gombos, Erin; Vinod, Amrit; Hoonjan, Gajinder

    2013-01-01

    Measures of complexity and entropy have not converged to a single quantitative description of levels of organization of complex systems. The need for such a measure is increasingly necessary in all disciplines studying complex systems. To address this problem, starting from the most fundamental principle in Physics, here a new measure for quantity of organization and rate of self-organization in complex systems based on the principle of least (stationary) action is applied to a model system -...

  1. [Septic shock due to infective endocarditis of stimulation system of implantable cardioverter-defibrillator].

    Science.gov (United States)

    Porubčinová, I; Porubčin, S; Stančák, B; Beňa, M; Sabol, F

    2012-01-01

    We present a case of a 60-year old patient hospitalized at the Department of Infectious Diseases and Travel Medicine, Medical faculty of UPJS and L. Pasteurs University Hospital in Kosice with suspected gastroenteritis. The patient was admitted to an intensive care unit because of the signs of septic shock. Within one hour from admission, the patient was administered early goal directed therapy for septic shock. Subsequently, infectious endocarditis of stimulation electrodes and tricuspid valve was identified as the origin of the infection. The stimulation system was then explanted from a stabilized and afebrile patient at the Department of cardiac Surgery of Eastern Slovak Institute of Cardiac and Vascular Diseases in Kosice. This case should emphasise frequently atypical course of this serious disease and the need for early identification of severe sepsis to enable timely management to affect mortality.

  2. Spiral shocks on a Roche lobe overflow in a semi-detached binary system

    International Nuclear Information System (INIS)

    Sawada, K.; Matsuda, T.; Hachisu, I.

    1986-01-01

    Two-dimensional hydrodynamic calculations of a Roche lobe overflow in a semi-detached binary system with a mass ratio of unity are carried out. The region of the computation covers both a mass-losing star filling its critical Roche lobe and a mass-accreting compact star. Gas ejected from the mass-losing star with specified energy flows through the L1 point to form an elephant trunk and an accretion ring. It is found that spiral-shaped shocks are formed on the accretion ring. It is suggested that the gas in the accretion ring loses angular momentum at the shocks and spirals in towards the compact star even without viscosity. (author)

  3. Bow Shock Generator Current Systems: MMS Observations of Possible Current Closure

    Science.gov (United States)

    Hamrin, M.; Gunell, H.; Lindkvist, J.; Lindqvist, P.-A.; Ergun, R. E.; Giles, B. L.

    2018-01-01

    We use data from the first two dayside seasons of the Magnetospheric Multiscale (MMS) mission to study current systems associated with quasi-perpendicular bow shocks of generator type. We have analyzed 154 MMS bow shock crossings near the equatorial plane. We compute the current density during the crossings and conclude that the component perpendicular to the shock normal (J⊥) is consistent with a pileup of the interplanetary magnetic field (IMF) inside the magnetosheath. For predominantly southward IMF, we observe a component Jn parallel (antiparallel) to the normal for GSM Y > 0 (MMS probing region. For IMF clock angles near 90∘, we find indications of the current system being tilted toward the north-south direction, obtaining a significant Jz component, and we suggest that the current closes off the equatorial plane at higher latitudes where the spacecraft are not probing. The observations are complicated for several reasons. For example, variations in the solar wind and the magnetospheric currents and loads affect the closure, and Jn is distributed over large regions, making it difficult to resolve inside the magnetosheath proper.

  4. Diabetes's 'health shock' to schooling and earnings: increased dropout rates and lower wages and employment in young adults.

    Science.gov (United States)

    Fletcher, Jason M; Richards, Michael R

    2012-01-01

    Despite a growing diabetes crisis, the nonmedical implications for young adults have gone virtually unexplored. We investigated the effects of diabetes on two key outcomes for this age group-schooling and earnings-and found that it delivers an increasingly common "health shock" to both. We identified effects in several measures of educational attainment, including a high school dropout rate that was six percentage points higher than among young adults without the disease. We also found lower employment and wages: A person with diabetes can conservatively expect to lose more than $160,000 over his or her working life, compared to a peer without the disease. For young adults with diabetes, having a parent with diabetes also leads to poorer outcomes than if one more parents do not have the disease-for example, reducing the likelihood of attending college by four to six percentage points, even after the child's health status is controlled for. These results highlight the urgency of attacking this growing health problem, as well as the need for measures such as in-school screening for whether diabetes's impact on individual learning and performance begins before the classic manifestations of clinical diabetes appear.

  5. Interaction between shock coils increased the incidence of inappropriate therapies and lead failure in implantable cardioverter defibrillator.

    Science.gov (United States)

    El Garhy, Mohammad; Ohlow, Marc-Alexander; Lauer, Bernward

    Shock coil interaction in patients with multiple implantable cardioverter defibrillator (ICD) leads is occasionally observed. We aimed to evaluate the incidence of shock coil interaction and its clinical relevance. All ICD patients (646 patients) who came to follow up control in our ICD ambulance between January 1, 2011, and December 31, 2011 in the department of cardiology in Bad Berka hospital were retrospectively evaluated in this study. All baseline demographic, clinical, and procedural characteristics and postoperative chest x ray in postero-anterior and lateral view as well as clinical and ICD follow up data were evaluated. Among 646 patients 42 had multiple ICD leads (6.5%) of whom 36 patients (5.5% of total cohort patients and 85.7% of patients with multiple ICD leads) had shock coil interaction and presented the study group (Group I). The control group (Group II) consisted of 610 patients without coil-coil interaction including patients with single shock lead (604 patients) or patients with multiple leads but without interaction between shock coils (6 patients). Inappropriate anti-tachycardia therapies and RV lead revisions were more frequent in patients with interaction between shock coils (Group I vs Group II: 27.7% and 5.7%; p = 0.049 and 30.6% vs 6.4; p = 0.0001, respectively). Interaction between shock coils may be one of possible causes of lead failure and resulted in inappropriate therapies and subsequent lead revision. Copyright © 2018 Indian Heart Rhythm Society. Production and hosting by Elsevier B.V. All rights reserved.

  6. STRATEGIES FOR INCREASING PRODUCTIVITY IN PRODUCTION SYSTEMS

    Directory of Open Access Journals (Sweden)

    Diego Pacheco

    2014-05-01

    Full Text Available The main objective of this article is to point a set of practical strategies that can be adopted to increase the capacity of constraints resources on production systems, when the constraint is inside the factory and not is in the market. To serve this purpose will be presented strategies based on best practices of the Theory of Constraints, Lean Manufacturing and Total Productive Maintenance. This article also presents the mains tools for the deployment of these methodologies. The survey results have provided an objective set of practical strategy that can be used to increase the capacity and productivity of production systems according to the needs of each manufacturing system.

  7. Increased extracellular heat shock protein 90α in severe sepsis and SIRS associated with multiple organ failure and related to acute inflammatory-metabolic stress response in children.

    Science.gov (United States)

    Fitrolaki, Michaela-Diana; Dimitriou, Helen; Venihaki, Maria; Katrinaki, Marianna; Ilia, Stavroula; Briassoulis, George

    2016-08-01

    Mammalian heat-shock-protein (HSP) 90α rapidly responses to environmental insults. We examined the hypothesis that not only serum HSP72 but also HSP90α is increased in the systemic inflammatory response syndrome (SIRS), severe-sepsis (SS), and/or sepsis (S) compared to healthy children (H); we assessed HSP90α relation to (a) multiple organ system failure (MOSF) and (b) inflammatory-metabolic response and severity of illness.A total of 65 children with S, SS, or SIRS and 25 H were included. ELISA was used to evaluate extracellular HSP90α and HSP72, chemiluminescence interleukins (ILs), flow-cytometry neutrophil-CD64 (nCD64)-expression.HSP90α, along with HSP72, were dramatically increased among MOSF patients. Patients in septic groups and SIRS had elevated HSP90α compared to H (P stress, fever, outcome endpoints, and predicted mortality and inversely related to the low-LDL/low-HDL stress metabolic pattern.

  8. 17-AAG improves cognitive process and increases heat shock protein response in a model lesion with Aβ25-35.

    Science.gov (United States)

    Ortega, Laura; Calvillo, Minerva; Luna, Félix; Pérez-Severiano, Francisca; Rubio-Osornio, Moisés; Guevara, Jorge; Limón, Ilhuicamina Daniel

    2014-08-01

    Molecular chaperones, or heat shock proteins (HSP), have been implicated in numerous neurodegenerative disorders characterized by the accumulation of protein aggregates, such as Alzheimer disease. The agglomeration of insoluble structures of Aβ is thought to be responsible for neuronal death, which in turn leads to the loss of cognitive functions. Recent findings have shown that the induction of HSP decreases the level of abnormal protein aggregates, as well as demonstrating that 17-(allylamino)-17-demethoxygeldanamycin (17-AAG), an analogue of geldanamycin (GA), increases Aβ clearance through the induction of molecular chaperones in cell culture. In light of this discovery that HSP overexpression can be neuroprotective, the search for a way to pharmacologically induce the overexpression of HSP and other associated chaperones may lead to a promising approach for the treatment of neurodegenerative diseases. The aim of our study was to evaluate both the effect of 17-AAG on the cognitive process and the HSP response in rats injected with Aβ25-35 into the CA1 of the hippocampus. The results show that the injection of Aβ caused a significant increase in the expression of the HSP involved in the regulation of cellular proteostasis. While the HSP did not reverse excitotoxic damage, given that experimental subjects showed learning and memory deficits, the administration of 17-AAG prior to the injection of Aβ25-35 did show an improvement in the behavioral assessment that correlated with the upregulation of HSP70 in subjects injured with Aβ. Overall, our data shows that the pharmacological induction of HSP using 17-AAG may be an alternative treatment of neurodegenerative diseases. Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. Accuracy of a real-time continuous glucose monitoring system in children with septic shock: A pilot study

    OpenAIRE

    Prabhudesai, Sumant; Kanjani, Amruta; Bhagat, Isha; Ravikumar, Karnam G.; Ramachandran, Bala

    2015-01-01

    Aims: The aim of this prospective, observational study was to determine the accuracy of a real-time continuous glucose monitoring system (CGMS) in children with septic shock. Subjects and Methods: Children aged 30 days to 18 years admitted to the Pediatric Intensive Care Unit with septic shock were included. A real-time CGMS sensor was used to obtain interstitial glucose readings. CGMS readings were compared statistically with simultaneous laboratory blood glucose (BG). Results: Nineteen chil...

  10. Shock Mechanism Analysis and Simulation of High-Power Hydraulic Shock Wave Simulator

    Directory of Open Access Journals (Sweden)

    Xiaoqiu Xu

    2017-01-01

    Full Text Available The simulation of regular shock wave (e.g., half-sine can be achieved by the traditional rubber shock simulator, but the practical high-power shock wave characterized by steep prepeak and gentle postpeak is hard to be realized by the same. To tackle this disadvantage, a novel high-power hydraulic shock wave simulator based on the live firing muzzle shock principle was proposed in the current work. The influence of the typical shock characteristic parameters on the shock force wave was investigated via both theoretical deduction and software simulation. According to the obtained data compared with the results, in fact, it can be concluded that the developed hydraulic shock wave simulator can be applied to simulate the real condition of the shocking system. Further, the similarity evaluation of shock wave simulation was achieved based on the curvature distance, and the results stated that the simulation method was reasonable and the structural optimization based on software simulation is also beneficial to the increase of efficiency. Finally, the combination of theoretical analysis and simulation for the development of artillery recoil tester is a comprehensive approach in the design and structure optimization of the recoil system.

  11. Ultrasonic Ranging System With Increased Resolution

    Science.gov (United States)

    Meyer, William E.; Johnson, William G.

    1987-01-01

    Master-oscillator frequency increased. Ultrasonic range-measuring system with 0.1-in. resolution provides continuous digital display of four distance readings, each updated four times per second. Four rangefinder modules in system are modified versions of rangefinder used for automatic focusing in commercial series of cameras. Ultrasonic pulses emitted by system innocuous to both people and equipment. Provides economical solutions to such distance-measurement problems as posed by boats approaching docks, truck backing toward loading platform, runway-clearance readout for tail of airplane with high angle attack, or burglar alarm.

  12. Geometrical shock dynamics for magnetohydrodynamic fast shocks

    KAUST Repository

    Mostert, W.; Pullin, D. I.; Samtaney, Ravi; Wheatley, V.

    2016-01-01

    We describe a formulation of two-dimensional geometrical shock dynamics (GSD) suitable for ideal magnetohydrodynamic (MHD) fast shocks under magnetic fields of general strength and orientation. The resulting area–Mach-number–shock-angle relation is then incorporated into a numerical method using pseudospectral differentiation. The MHD-GSD model is verified by comparison with results from nonlinear finite-volume solution of the complete ideal MHD equations applied to a shock implosion flow in the presence of an oblique and spatially varying magnetic field ahead of the shock. Results from application of the MHD-GSD equations to the stability of fast MHD shocks in two dimensions are presented. It is shown that the time to formation of triple points for both perturbed MHD and gas-dynamic shocks increases as (Formula presented.), where (Formula presented.) is a measure of the initial Mach-number perturbation. Symmetry breaking in the MHD case is demonstrated. In cylindrical converging geometry, in the presence of an azimuthal field produced by a line current, the MHD shock behaves in the mean as in Pullin et al. (Phys. Fluids, vol. 26, 2014, 097103), but suffers a greater relative pressure fluctuation along the shock than the gas-dynamic shock. © 2016 Cambridge University Press

  13. Geometrical shock dynamics for magnetohydrodynamic fast shocks

    KAUST Repository

    Mostert, W.

    2016-12-12

    We describe a formulation of two-dimensional geometrical shock dynamics (GSD) suitable for ideal magnetohydrodynamic (MHD) fast shocks under magnetic fields of general strength and orientation. The resulting area–Mach-number–shock-angle relation is then incorporated into a numerical method using pseudospectral differentiation. The MHD-GSD model is verified by comparison with results from nonlinear finite-volume solution of the complete ideal MHD equations applied to a shock implosion flow in the presence of an oblique and spatially varying magnetic field ahead of the shock. Results from application of the MHD-GSD equations to the stability of fast MHD shocks in two dimensions are presented. It is shown that the time to formation of triple points for both perturbed MHD and gas-dynamic shocks increases as (Formula presented.), where (Formula presented.) is a measure of the initial Mach-number perturbation. Symmetry breaking in the MHD case is demonstrated. In cylindrical converging geometry, in the presence of an azimuthal field produced by a line current, the MHD shock behaves in the mean as in Pullin et al. (Phys. Fluids, vol. 26, 2014, 097103), but suffers a greater relative pressure fluctuation along the shock than the gas-dynamic shock. © 2016 Cambridge University Press

  14. Control of adverse effects of explosive blasting in mines by using shock tube (non-electric) initiation systems and its future challenges

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, P.D. [Maharashtra Explosives Ltd., Nagpur (India)

    2000-04-01

    Every kind of blasting in mines produces some adverse effects on environment, such as ground vibration, noise, fly rock etc. Presently, for restricting these adverse effects, use of shock tube (non-electric) initiation systems are gaining momentum. There are some inherent shortcomings of this initiation system regarding chances of misfires. This paper discusses the various adverse effects of blasting, advantages of shock tube initiation system and the shortcomings of shock tube initiation system regarding chances of misfire and how misfire arises out of failure of shock tube initiation system is different and more dangerous than the misfire occurring due to failure of conventional system (with detonating fuse and cord relays). 1 tab.

  15. Analysis of Reactor Pressurized Thermal Shock Conditions Considering Upgrading of Systems Important to Safety

    International Nuclear Information System (INIS)

    Mazurok, A.S; Vyshemirskyij, M.P.

    2015-01-01

    The paper analyzes conditions of pressurized thermal shock on the reactor pressure vessel taking into account upgrading of the emergency core cooling system and primary overpressure protection system. For representative accident scenarios, calculation and comparative analysis was carried out. These scenarios include a small leak from the hot leg and PRZ SV stuck opening with re closure after 3600 sec and 3 SG heat transfer tube rupture. The efficiency of mass flow control by valves on the pump head (emergency core cooling systems) and cold overpressure protection (primary overpressure protection system) was analyzed. The thermal hydraulic model for RELAP5/Mod3.2 code with detailed downcomer (DC) model and changes in accordance with upgrades was used for calculations. Detailed (realistic) modeling of piping and equipment was performed. The upgrades prevent excessive primary cooling and, consequently, help to preserve the RPV integrity and to avoid the formation of a through crack, which can lead to a severe accident

  16. Noninvasive optoacoustic system for rapid diagnostics and management of circulatory shock

    Science.gov (United States)

    Esenaliev, Rinat O.; Petrov, Irene Y.; Petrov, Yuriy; Kinsky, Michael; Prough, Donald S.

    2012-02-01

    Circulatory shock is lethal, if not promptly diagnosed and effectively treated. Typically, circulatory shock resuscitation is guided by blood pressure, heart rate, and mental status, which have poor predictive value. In patients, in whom early goaldirected therapy was applied using central venous oxygenation measurement, a substantial reduction of mortality was reported (from 46.5% to 30%). However, central venous catheterization is invasive, time-consuming and often results in complications. We proposed to use the optoacoustic technique for noninvasive, rapid assessment of central venous oxygenation. In our previous works we demonstrated that the optoacoustic technique can provide measurement of blood oxygenation in veins and arteries due to high contrast and high resolution. In this work we developed a novel optoacoustic system for noninvasive, automatic, real-time, and continuous measurement of central venous oxygenation. We performed pilot clinical tests of the system in human subjects with different oxygenation in the internal jugular vein and subclavian vein. A novel optoacoustic interface incorporating highly-sensitive optoacoustic probes and standard ultrasound imaging probes were developed and built for the study. Ultrasound imaging systems Vivid i and hand-held Vscan (GE Healthcare) as well as Site-Rite 5 (C.R. Bard) were used in the study. We developed a special algorithm for oxygenation monitoring with minimal influence of overlying tissue. The data demonstrate that the system provides precise measurement of venous oxygenation continuously and in real time. Both current value of the venous oxygenation and trend (in absolute values and for specified time intervals) are displayed in the system. The data indicate that: 1) the optoacoustic system developed by our group is capable of noninvasive measurement of blood oxygenation in specific veins; 2) clinical ultrasound imaging systems can facilitate optoacoustic probing of specific blood vessels; 3) the

  17. δ- and δ'-shock wave types of singular solutions of systems of conservation laws and transport and concentration processes

    International Nuclear Information System (INIS)

    Shelkovich, V M

    2008-01-01

    This is a survey of some results and problems connected with the theory of generalized solutions of quasi-linear conservation law systems which can admit delta-shaped singularities. They are the so-called δ-shock wave type solutions and the recently introduced δ (n) -shock wave type solutions, n=1,2,..., which cannot be included in the classical Lax-Glimm theory. The case of δ- and δ'-shock waves is analyzed in detail. A specific analytical technique is developed to deal with such solutions. In order to define them, some special integral identities are introduced which extend the concept of weak solution, and the Rankine-Hugoniot conditions are derived. Solutions of Cauchy problems are constructed for some typical systems of conservation laws. Also investigated are multidimensional systems of conservation laws (in particular, zero-pressure gas dynamics systems) which admit δ-shock wave type solutions. A geometric aspect of such solutions is considered: they are connected with transport and concentration processes, and the balance laws of transport of 'volume' and 'area' to δ- and δ'-shock fronts are derived for them. For a 'zero-pressure gas dynamics' system these laws are the mass and momentum transport laws. An algebraic aspect of these solutions is also considered: flux-functions are constructed for them which, being non-linear, are nevertheless uniquely defined Schwartz distributions. Thus, a singular solution of the Cauchy problem generates algebraic relations between its components (distributions).

  18. A shock and wear system under environmental conditions subject to internal failures, repair, and replacement

    International Nuclear Information System (INIS)

    Montoro-Cazorla, Delia; Pérez-Ocón, Rafael

    2012-01-01

    A system in a random environment is considered. The influence of the external conditions is governed by a Markovian arrival process. The internal structure of failure and repair are governed by phase-type distributions. The maintenance is performed by policy N. Under these assumptions, the Markov process governing the system is constructed, and it is studied in transient and stationary regime, calculating the availability and the rate of occurrence of failures. The renewal process due to the replacements of the system is studied, and expressions for the number of replacements and for the number of repairs between replacements are calculated. This paper extends other previously published since it incorporates a shock arrival process with dependence among the interarrival times and the renewal process associated to the replacements. A numerical application illustrates the calculations.

  19. Comparison of severity of illness scoring systems in the prediction of hospital mortality in severe sepsis and septic shock

    Directory of Open Access Journals (Sweden)

    Crowe Colleen

    2010-01-01

    Full Text Available Background : New scoring systems, including the Rapid Emergency Medicine Score (REMS, the Mortality in Emergency Department Sepsis (MEDS score, and the confusion, urea nitrogen, respiratory rate, blood pressure, 65 years and older (CURB-65 score, have been developed for emergency department (ED use in various patient populations. Increasing use of early goal directed therapy (EGDT for the emergent treatment of sepsis introduces a growing population of patients in which the accuracy of these scoring systems has not been widely examined. Objectives : To evaluate the ability of the REMS, MEDS score, and CURB-65 score to predict mortality in septic patients treated with modified EGDT. Materials and Methods : Secondary analysis of data from prospectively identified patients treated with modified EGDT in a large tertiary care suburban community hospital with over 85,000 ED visits annually and 700 inpatient beds, from May 2007 through May 2008. We included all patients with severe sepsis or septic shock, who were treated with our modified EGDT protocol. Our major outcome was in-hospital mortality. The performance of the scores was compared by area under the ROC curves (AUCs. Results : A total of 216 patients with severe sepsis or septic shock were treated with modified EGDT during the study period. Overall mortality was 32.9%. Calculated AUCs were 0.74 [95% confidence interval (CI: 0.67-0.81] for the MEDS score, 0.62 (95% CI: 0.54-0.69 for the REMS, and 0.59 (95% CI: 0.51-0.67 for the CURB-65 score. Conclusion : We found that all three ED-based systems for scoring severity of illness had low to moderate predictive capability. The MEDS score demonstrated the largest AUC of the studied scoring systems for the outcome of mortality, although the CIs on point estimates of the AUC of the REMS and CURB-65 scores all overlap.

  20. Heat shock and thermotolerance of Escherichia coli O157:H7 in a model beef gravy system and ground beef.

    Science.gov (United States)

    Juneja, V K; Klein, P G; Marmer, B S

    1998-04-01

    Duplicate beef gravy or ground beef samples inoculated with a suspension of a four-strain cocktail of Escherichia coli O157:H7 were subjected to sublethal heating at 46 degrees C for 15-30 min, and then heated to a final internal temperature of 60 degrees C. Survivor curves were fitted using a linear model that incorporated a lag period (TL), and D-values and 'time to a 4D inactivation' (T4D) were calculated. Heat-shocking allowed the organism to survive longer than non-heat-shocked cells; the T4D values at 60 degrees C increased 1.56- and 1.50-fold in beef gravy and ground beef, respectively. In ground beef stored at 4 degrees C, thermotolerance was lost after storage for 14 h. However, heat-shocked cells appeared to maintain their thermotolerance for at least 24 h in ground beef held to 15 or 28 degrees C. A 25 min heat shock at 46 degrees C in beef gravy resulted in an increase in the levels of two proteins with apparent molecular masses of 60 and 69 kDa. These two proteins were shown to be immunologically related to GroEL and DnaK, respectively. Increased heat resistance due to heat shock must be considered while designing thermal processes to assure the microbiological safety of thermally processed foods.

  1. Hydrocortisone fails to abolish NF-κB1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG and is associated with increased 30-day mortality in septic shock.

    Directory of Open Access Journals (Sweden)

    Simon T Schäfer

    Full Text Available BACKGROUND: Previous investigations and meta-analyses on the effect of glucocorticoids on mortality in septic shock revealed mixed results. This heterogeneity might be evoked by genetic variations. Such candidate is a promoter polymorphism (-94ins/delATTG of the gene encoding the ubiquitous transcription-factor nuclear-factor-κB (NF-κB which binds to recognition elements in the promoter of several genes encoding for the innate immune-system. In turn, hydrocortisone inhibits NF-κB nuclear translocation and thus transcription of key immune-response regulators. Accordingly, we tested the hypotheses that hydrocortisone has a NFKB1 genotype dependent effect on 1 NF-κB1 nuclear translocation evoked by lipopolysaccharide (LPS in monocytes in vitro, and 2 mortality in septic shock. METHODS: Monocytes of volunteers with the homozygous insertion (II; n = 5 or deletion (DD; n = 6 NFKB1 genotype were incubated with 10 µgml-1 LPS ± hydrocortisone (10-5M, and NF-κB1 nuclear translocation was assessed (immunofluorescence. Furthermore, we analyzed 30-day-mortality in 160 patients with septic shock stratified for both genotype and hydrocortisone therapy. RESULTS: Hydrocortisone inhibited LPS induced nuclear translocation of NF-κB1 in II (25%±11;p = 0.0001 but not in DD genotypes (51%±15;p = n.s.. Onehundredandfour of 160 patients with septic shock received hydrocortisone, at the discretion of the intensivist. NFKB1 deletion allele carriers (ID/DD receiving hydrocortisone had a much greater 30-day-mortality (57.6% than II genotypes (24.4%; HR:3.18, 95%-CI:1.61-6.28;p = 0.001. In contrast, 30-day mortality was 22.2% in ID/DD and 25.0% in II genotypes without hydrocortisone therapy. Results were similar when using propensity score matching to account for possible bias in the intensivists' decision to administer hydrocortisone. CONCLUSION: Hydrocortisone fails to inhibit LPS induced nuclear NF-κB1 translocation in deletion allele

  2. Hydrocortisone Fails to Abolish NF-κB1 Protein Nuclear Translocation in Deletion Allele Carriers of the NFKB1 Promoter Polymorphism (-94ins/delATTG) and Is Associated with Increased 30-Day Mortality in Septic Shock

    Science.gov (United States)

    Schäfer, Simon T.; Gessner, Sophia; Scherag, André; Rump, Katharina; Frey, Ulrich H.; Siffert, Winfried; Westendorf, Astrid M.; Steinmann, Jörg; Peters, Jürgen; Adamzik, Michael

    2014-01-01

    Background Previous investigations and meta-analyses on the effect of glucocorticoids on mortality in septic shock revealed mixed results. This heterogeneity might be evoked by genetic variations. Such candidate is a promoter polymorphism (-94ins/delATTG) of the gene encoding the ubiquitous transcription-factor nuclear-factor-κB (NF-κB) which binds to recognition elements in the promoter of several genes encoding for the innate immune-system. In turn, hydrocortisone inhibits NF-κB nuclear translocation and thus transcription of key immune-response regulators. Accordingly, we tested the hypotheses that hydrocortisone has a NFKB1 genotype dependent effect on 1) NF-κB1 nuclear translocation evoked by lipopolysaccharide (LPS) in monocytes in vitro, and 2) mortality in septic shock. Methods Monocytes of volunteers with the homozygous insertion (II; n = 5) or deletion (DD; n = 6) NFKB1 genotype were incubated with 10 µgml-1 LPS ± hydrocortisone (10-5M), and NF-κB1 nuclear translocation was assessed (immunofluorescence). Furthermore, we analyzed 30-day-mortality in 160 patients with septic shock stratified for both genotype and hydrocortisone therapy. Results Hydrocortisone inhibited LPS induced nuclear translocation of NF-κB1 in II (25%±11;p = 0.0001) but not in DD genotypes (51%±15;p = n.s.). Onehundredandfour of 160 patients with septic shock received hydrocortisone, at the discretion of the intensivist. NFKB1 deletion allele carriers (ID/DD) receiving hydrocortisone had a much greater 30-day-mortality (57.6%) than II genotypes (24.4%; HR:3.18, 95%-CI:1.61-6.28;p = 0.001). In contrast, 30-day mortality was 22.2% in ID/DD and 25.0% in II genotypes without hydrocortisone therapy. Results were similar when using propensity score matching to account for possible bias in the intensivists' decision to administer hydrocortisone. Conclusion Hydrocortisone fails to inhibit LPS induced nuclear NF-κB1 translocation in deletion allele carriers of the

  3. The dynamics of heat shock system activation in Monomac-6 cells upon Helicobacter pylori infection.

    Science.gov (United States)

    Pierzchalski, P; Jastrzebska, M; Link-Lenczowski, P; Leja-Szpak, A; Bonior, J; Jaworek, J; Okon, K; Wojcik, P

    2014-12-01

    Immune system cells, particularly phagocytes, are exposed to direct contact with pathogens. Because of its nature - elimination of pathogenes - their cytoprotective systems supposed to be quick and forceful. Physiological consequence of phagocytosis for the phagocyte is the apoptotic death to prevent the eventual survival of bacteria as intracellular parasites. However, in some cases, defense systems used by the bacteria force the immune cells to prolong the contact with the pathogen for its effective elimination. Experiments were performed on Monomac-6 cells exposed to live CagA, VacA expressing Helicobacter pylori (H. pylori) over different period of time. Total cellular RNA, cytoplasmic and nuclear proteins were isolated for polymerase chain reaction, Western-blot and electrophoretic mobility shift assay, respectively. We found that Monomac-6 cells infection with H. pylori resulted in the translocation of the entire cellular content of the heat shock protein 70 (HSP70) into the cytoplasm, where its presence could protect cell against toxic products of engulfed bacteria and premature apoptosis. At the same time the nuclear translocation of heat shock factor 1 (HSF-1) and activation of HSP70 gene transcription was noticed. Action of HSP70 might to postpone monocyte apoptosis through protecting cytoplasmic and nuclear proteins from damaging effect of bacterial products, what could be the defending mechanism against the toxic stress caused by engulfed bacteria and provide the immune cell with the sufficient amount of time required for neutralization of the bacteria from phagosomes, even at the expense of temporary lack of the protection of nuclear proteins.

  4. A condition-based maintenance of a dependent degradation-threshold-shock model in a system with multiple degradation processes

    International Nuclear Information System (INIS)

    Caballé, N.C.; Castro, I.T.; Pérez, C.J.; Lanza-Gutiérrez, J.M.

    2015-01-01

    This paper proposes a condition-based maintenance strategy for a system subject to two dependent causes of failure: degradation and sudden shocks. The internal degradation is reflected by the presence of multiple degradation processes in the system. Degradation processes start at random times following a Non-homogeneous Poisson process and their growths are modelled by using a gamma process. When the deterioration level of a degradation process exceeds a predetermined value, we assume that a degradation failure occurs. Furthermore, the system is subject to sudden shocks that arrive at the system following a Doubly Stochastic Poisson Process. A sudden shock provokes the total breakdown of the system. Thus, the state of the system is evaluated at inspection times and different maintenance tasks can be carried out. If the system is still working at an inspection time, a preventive maintenance task is performed if the deterioration level of a degradation process exceeds a certain threshold. A corrective maintenance task is performed if the system is down at an inspection time. A preventive (corrective) maintenance task implies the replacement of the system by a new one. Under this maintenance strategy, the expected cost rate function is obtained. A numerical example illustrates the analytical results. - Highlights: • A condition-based maintenance model is proposed. • Two dependent causes of failure are considered: deterioration and external shocks. • Deterioration is given by multiple degradation processes growing by a gamma process. • The initiation of degradation processes follows a Non-homogeneous Poisson process. • External shocks arrive at the system by using a Doubly Stochastic Poisson Process

  5. On problems to be solved for utilizing shock isolation systems to NPP

    International Nuclear Information System (INIS)

    Shibata, H.; Shigeta, T.; Komine, H.

    1989-01-01

    This paper discusses the development of difficulties with light water fast breeder reactors (LFBR). The authors focus their discussion on thin wall reactor vessels, thin wall sodium loops, and large sodium pools with free surfaces. Conclusions considered are to lower the center of gravity and the use of shock isolation system. Since the success of Super-phenix, the interest to develop a large fast reactor, so called LFBR, has become more realistic one in Japan. However, the anti-earthquake design of a pool-type large fast reactor is more difficult than that of light water reactors for high seismicity areas like Japan. The reason of difficulties come from the difference of the structural requirement for LFBR. Three major points are as follows: thin wall reactor vessel, thin wall sodium loops, large sodium pool with free surface

  6. Glovebox-contained forty-millimeter gun system for the study of one-dimensional shock waves in toxic materials

    International Nuclear Information System (INIS)

    Honodel, C.A.

    1975-01-01

    A new gun system is being constructed at the Lawrence Livermore Laboratory for studies of the behavior of toxic materials under shock-loaded conditions. Due to the extreme toxicity of some materials, such as plutonium, the entire gun system must be enclosed in gloveboxes. Some of the experimental requirements that affected the design of the system, various diagnostic techniques that will be employed with the system, and some details of the final design that is presently under assembly are presented

  7. Key role of the expression of bone morphogenetic proteins in increasing the osteogenic activity of osteoblast-like cells exposed to shock waves and seeded on bioactive glass-ceramic scaffolds for bone tissue engineering.

    Science.gov (United States)

    Muzio, Giuliana; Martinasso, Germana; Baino, Francesco; Frairia, Roberto; Vitale-Brovarone, Chiara; Canuto, Rosa A

    2014-11-01

    In this work, the role of shock wave-induced increase of bone morphogenetic proteins in modulating the osteogenic properties of osteoblast-like cells seeded on a bioactive scaffold was investigated using gremlin as a bone morphogenetic protein antagonist. Bone-like glass-ceramic scaffolds, based on a silicate experimental bioactive glass developed at the Politecnico di Torino, were produced by the sponge replication method and used as porous substrates for cell culture. Human MG-63 cells, exposed to shock waves and seeded on the scaffolds, were treated with gremlin every two days and analysed after 20 days for the expression of osteoblast differentiation markers. Shock waves have been shown to induce osteogenic activity mediated by increased expression of alkaline phosphatase, osteocalcin, type I collagen, BMP-4 and BMP-7. Cells exposed to shock waves plus gremlin showed increased growth in comparison with cells treated with shock waves alone and, conversely, mRNA contents of alkaline phosphatase and osteocalcin were significantly lower. Therefore, the shock wave-mediated increased expression of bone morphogenetic protein in MG-63 cells seeded on the scaffolds is essential in improving osteogenic activity; blocking bone morphogenetic protein via gremlin completely prevents the increase of alkaline phosphatase and osteocalcin. The results confirmed that the combination of glass-ceramic scaffolds and shock waves exposure could be used to significantly improve osteogenesis opening new perspectives for bone regenerative medicine. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  8. Investigation of external and internal shock in the stability of Indonesia’s financial system

    Directory of Open Access Journals (Sweden)

    Maulina Vinus

    2017-07-01

    Full Text Available The objective of this research is to develop a financial system stability index and analyze the internal and external factors that we expect to affect the stability of the Indonesian financial system. We measured the single model of financial system stability index (FSSI from year 2004M03 to2014M09 in Indonesia, and compiled a single quantitative measure based on aggregate internal factors and external factors to capture and predict the shocks of the financial system stability. Stability parameters were composed of composite indicators on different bases. In addition, we developed a comprehensive index component associated with the relevant market conditions, including banking soundness index, financial vulnerability index, and regional economic climate index. Results stated that US economic growth and economic growth of ASEAN countries positively affected financial stability. In addition, current account, exchange rate, inflation, interest rate were shown to negatively affect financial stability. The results of this study imply that internal factors have a strong influence on the financial stability. Therefore, the central bank should give a fast and correct response to the changes of external and internal financial environment, especially for internal factors through monetary policy.

  9. MIGRE: an Expert System as an aid for loose part diagnosis and mechanical shocks interpretation in nuclear plant

    International Nuclear Information System (INIS)

    Monnier, B.; Puyal, C.; Fernandes, A.; Martin, C.

    1990-01-01

    This paper presents an application of the expert system technique to one of the functions which participate to the surveillance of the primary circuit of water-pressurized reactors: the detection of loose parts and the interpretation of mechanical shocks. First, we describe the domain of expertise and the context in which this expert system will be used. Then we deal with the principles and the different levels involved in the knowledge modeling and with the structure of the expert system

  10. State and parameter estimation of the heat shock response system using Kalman and particle filters.

    Science.gov (United States)

    Liu, Xin; Niranjan, Mahesan

    2012-06-01

    Traditional models of systems biology describe dynamic biological phenomena as solutions to ordinary differential equations, which, when parameters in them are set to correct values, faithfully mimic observations. Often parameter values are tweaked by hand until desired results are achieved, or computed from biochemical experiments carried out in vitro. Of interest in this article, is the use of probabilistic modelling tools with which parameters and unobserved variables, modelled as hidden states, can be estimated from limited noisy observations of parts of a dynamical system. Here we focus on sequential filtering methods and take a detailed look at the capabilities of three members of this family: (i) extended Kalman filter (EKF), (ii) unscented Kalman filter (UKF) and (iii) the particle filter, in estimating parameters and unobserved states of cellular response to sudden temperature elevation of the bacterium Escherichia coli. While previous literature has studied this system with the EKF, we show that parameter estimation is only possible with this method when the initial guesses are sufficiently close to the true values. The same turns out to be true for the UKF. In this thorough empirical exploration, we show that the non-parametric method of particle filtering is able to reliably estimate parameters and states, converging from initial distributions relatively far away from the underlying true values. Software implementation of the three filters on this problem can be freely downloaded from http://users.ecs.soton.ac.uk/mn/HeatShock

  11. Mixing and entropy increase in quantum systems

    International Nuclear Information System (INIS)

    Narnhofer, H.; Pflug, A.; Thirring, W.

    1989-01-01

    This paper attempts to explain the key feature of deterministic chaotic classical systems and how they can be translated to quantum systems. To do so we develop the appropriate algebraic language for the non-specialist. 22 refs. (Author)

  12. Shock Prevention

    Science.gov (United States)

    1978-01-01

    The electrician pictured is installing a General Electric Ground Fault Interrupter (GFI), a device which provides protection against electrical shock in the home or in industrial facilities. Shocks due to defective wiring in home appliances or other electrical equipment can cause severe burns, even death. As a result, the National Electrical Code now requires GFIs in all new homes constructed. This particular type of GFI employs a sensing element which derives from technology acquired in space projects by SCI Systems, Inc., Huntsville, Alabama, producer of sensors for GE and other manufacturers of GFI equipment. The sensor is based on the company's experience in developing miniaturized circuitry for space telemetry and other spacecraft electrical systems; this experience enabled SCI to package interruptor circuitry in the extremely limited space available and to produce sensory devices at practicable cost. The tiny sensor measures the strength of the electrical current and detects current differentials that indicate a fault in the functioning of an electrical system. The sensing element then triggers a signal to a disconnect mechanism in the GFI, which cuts off the current in the faulty circuit.

  13. Increased expression of heat shock protein 105 in rat uterus of early pregnancy and its significance in embryo implantation

    Directory of Open Access Journals (Sweden)

    Hu Zhao-Yuan

    2009-03-01

    Full Text Available Abstract Background Heat shock proteins (Hsps are a set of highly conserved proteins, Hsp105, has been suggested to play a role in reproduction. Methods Spatio-temporal expression of Hsp105 in rat uterus during peri-implantation period was examined by immunohistochemistry and Western blot, pseudopregnant uterus was used as control. Injection of antisense oligodeoxynucleotides to Hsp105 into pregnant rat uteri was carried out to look at effect of Hsp105 on embryo implantation. Results Expression of Hsp105 was mainly in the luminal epithelium on day 1 of pregnancy, and reached a peak level on day 5, whereas in stroma cells, adjacent to the implanting embryo, the strongest expression of Hsp105 was observed on day 6. The immunostaining profile in the uterus was consistent with that obtained by Western blot in the early pregnancy. In contrast, no obvious peak level of Hsp105 was observed in the uterus of pseudopregnant rat on day 5 or day 6. Furthermore, injection of antisense oligodeoxynucleotides to Hsp105 into the rat uterine horn on day 3 of pregnancy obviously suppressed the protein expression as expected and reduced number of the implanted embryos as compared with the control. Conclusion Temporal and spatial changes in Hsp105 expression in pregnant rat uterus may play a physiological role in regulating embryo implantation.

  14. The Whitham approach to dispersive shocks in systems with cubic–quintic nonlinearities

    KAUST Repository

    Crosta, M

    2012-09-12

    By employing a rigorous approach based on the Whitham modulation theory, we investigate dispersive shock waves arising in a high-order nonlinear Schrödinger equation with competing cubic and quintic nonlinear responses. This model finds important applications in both nonlinear optics and Bose–Einstein condensates. Our theory predicts the formation of dispersive shocks with totally controllable properties, encompassing both steering and compression effects. Numerical simulations confirm these results perfectly. Quite remarkably, shock tuning can be achieved in the regime of a very small high order, i.e. quintic, nonlinearity.

  15. The Whitham approach to dispersive shocks in systems with cubic–quintic nonlinearities

    KAUST Repository

    Crosta, M; Trillo, S; Fratalocchi, Andrea

    2012-01-01

    By employing a rigorous approach based on the Whitham modulation theory, we investigate dispersive shock waves arising in a high-order nonlinear Schrödinger equation with competing cubic and quintic nonlinear responses. This model finds important applications in both nonlinear optics and Bose–Einstein condensates. Our theory predicts the formation of dispersive shocks with totally controllable properties, encompassing both steering and compression effects. Numerical simulations confirm these results perfectly. Quite remarkably, shock tuning can be achieved in the regime of a very small high order, i.e. quintic, nonlinearity.

  16. Bibliographic Information Retrieval Systems: Increasing Cognitive Compatibility.

    Science.gov (United States)

    Smith, Philip J.; And Others

    1987-01-01

    Discusses the impact of research in artificial intelligence and human computer interaction on the design of bibliographic information retrieval systems, and presents design principles of a prototype system that uses semantically based searches and a knowledge base consisting of conceptual frames. (10 references) (CLB)

  17. System for increasing laser pulse rate

    International Nuclear Information System (INIS)

    1980-01-01

    A technique of static elements is disclosed for combining a plurality of laser beams having time sequenced, pulsed radiation to achieve an augmented pulse rate. The technique may also be applied in a system for combining both time sequenced pulses and frequency distinct pulses for use in a system for isotope enrichment. (author)

  18. Radioisotope Thermoelectric Generator Transporation System licensed hardware second certification test series and package shock mount system test

    International Nuclear Information System (INIS)

    Ferrell, P.C.; Moody, D.A.

    1995-10-01

    This paper presents a summary of two separate drop test a e performed in support of the Radioisotope Thermoelectric Generator (RTG) Transportation System (RTGTS). The first portion of this paper presents the second series of drop testing required to demonstrate that the RTG package design meets the requirements of Title 10, Code of Federal Regulations, ''Part 71'' (10 CFR 71). Results of the first test series, performed in July 1994, demonstrated that some design changes were necessary. The package design was modified to improve test performance and the design changes were incorporated into the Safety Analysis Report for Packaging (SARP). The second full-size certification test article (CTA-2) incorporated the modified design and was tested at the US Department of Energy's (DOE) Hanford Site near Richland, Washington. With the successful completion of the test series, and pending DOE Office of Facility Safety Analysis approval of the SARP, a certificate of compliance will be issued for the RTG package allowing its use. The second portion of this paper presents the design and testing of the RTG Package Mount System. The RTG package mount was designed to protect the RTG from excessive vibration during transport, provide shock protection during on/off loading, and provide a mechanism for moving the RTG package with a forklift. Military Standard (MIL-STD) 810E, Transit Drop Procedure (DOE 1989), was used to verify that the shock limiting system limited accelerations in excess of 15 G's at frequencies below 150 Hz. Results of the package mount drop tests indicate that an impact force of 15 G's was not exceeded in any test from a free drop height of 457 mm (18 in.)

  19. Fatal Candida septic shock during systemic chemotherapy in lung cancer patient receiving corticosteroid replacement therapy for hypopituitarism. A case report

    International Nuclear Information System (INIS)

    Morichika, Daisuke; Sato-Hisamoto, Akiko; Hotta, Katsuyuki

    2014-01-01

    Invasive candidiasis has increased as nosocomial infection recently in cancer patients who receive systemic chemotherapy, and the timely risk assessment for developing such specific infection is crucial. Especially in those concomitantly with hypopituitarism, febrile neutropenia with candidiasis can cause severe stress and lead potentially to sudden fatal outcome when the temporal steroid coverage for the adrenal insufficiency is not fully administered. We report a 72-year-old male case diagnosed as non-small-cell lung cancer, Stage 3A. He had received a steroid replacement therapy for the prior history of hypophysectomy due to pituitary adenoma with hydrocortisone of 3.3 mg/day, equivalent to prednisolone of 0.8 mg/day. This very small dosage of steroid was hardly supposed to weaken his immune system, but rather potentially led to an inappropriate supplementation of his adrenal function, assuming that the serum sodium and chlorine levels decreased. On Day 6 of second cycle of chemotherapy with carboplatin and paclitaxel, he developed sudden febrile neutropenia, septic shock and ileus, leading to death. After his death, the venous blood culture on Day 7 detected Candida albicans. Autopsy findings showed a massive necrotizing enterocolitis with extensive Candida invasion into submucous tissue. In conclusion, this case may suggest that (1) immediate initiation of antifungal therapy soon after the careful risk assessment of Candida infection and (2) adequate administration of both basal steroid replacement therapy and temporal steroid coverage for febrile neutropenia might have improved his fatal outcome. (author)

  20. Mounted Combat System Crew Shock Loading: Head and Neck Injury Potential Evaluation

    National Research Council Canada - National Science Library

    LaFiandra, Michael E; Zywiol, Harry

    2007-01-01

    ...) ride motion simulator (RMS) was used to simulate the effects of gun firing shock on a Hybrid III instrumented anthropometric test device capable of measuring neck force and torque and head acceleration...

  1. Laser Induced Shock Waves and Vaporization in Biological System and Material Science

    National Research Council Canada - National Science Library

    Gerstman, Bernard S

    2008-01-01

    .... We have developed a computational model that allows the calculation of damage resulting from a laser pulse of any duration or energy due to temperature rise, explosive bubble formation, and shock wave production...

  2. Reversible thermal transition in GrpE, the nucleotide exchange factor of the DnaK heat-shock system.

    Science.gov (United States)

    Grimshaw, J P; Jelesarov, I; Schönfeld, H J; Christen, P

    2001-03-02

    DnaK, a Hsp70 acting in concert with its co-chaperones DnaJ and GrpE, is essential for Escherichia coli to survive environmental stress, including exposure to elevated temperatures. Here we explored the influence of temperature on the structure of the individual components and the functional properties of the chaperone system. GrpE undergoes extensive but fully reversible conformational changes in the physiologically relevant temperature range (transition midpoint at approximately 48 degrees C), as observed with both circular dichroism measurements and differential scanning calorimetry, whereas no thermal transitions occur in DnaK and DnaJ between 15 degrees C and 48 degrees C. The conformational changes in GrpE appear to be important in controlling the interconversion of T-state DnaK (ATP-liganded, low affinity for polypeptide substrates) and R-state DnaK (ADP-liganded, high affinity for polypeptide substrates). The rate of the T --> R conversion of DnaK due to DnaJ-triggered ATP hydrolysis follows an Arrhenius temperature dependence. In contrast, the rate of the R --> T conversion due to GrpE-catalyzed ADP/ATP exchange increases progressively less with increasing temperature and even decreases at temperatures above approximately 40 degrees C, indicating a temperature-dependent reversible inactivation of GrpE. At heat-shock temperatures, the reversible structural changes of GrpE thus shift DnaK toward its high-affinity R state.

  3. Stationary Shock Waves with Oscillating Front in Dislocation Systems of Semiconductors

    Science.gov (United States)

    Gestrin, S. G.; Shchukina, E. V.

    2018-05-01

    The paper presents a study of weakly nonlinear wave processes in the cylindrical region of a hole gas surrounding a negatively charged dislocation in an n-type semiconductor crystal. It is shown that shock waves propagating along the dislocation are the solutions of the Korteweg-de Vries-Burgers equation when the dispersion and dissipation of medium are taken into account. Estimates are obtained for the basic physical parameters characterizing the shock wave and the region inside the Reed cylinder.

  4. The ways of SOFC systems efficiency increasing

    Energy Technology Data Exchange (ETDEWEB)

    Demin, A.K.; Timofeyeva, N.

    1996-04-01

    The efficiency of solid oxide fuel cells (SOFCs) is described. This paper considers methods to lift the fuel utilization and/or the average cell voltage with the goal of increasing the cell efficiency by improved cell designs.

  5. Vulnerability to shocks in the global seafood trade network

    Science.gov (United States)

    Gephart, Jessica A.; Rovenskaya, Elena; Dieckmann, Ulf; Pace, Michael L.; Brännström, Åke

    2016-03-01

    Trade can allow countries to overcome local or regional losses (shocks) to their food supply, but reliance on international food trade also exposes countries to risks from external perturbations. Countries that are nutritionally or economically dependent on international trade of a commodity may be adversely affected by such shocks. While exposure to shocks has been studied in financial markets, communication networks, and some infrastructure systems, it has received less attention in food-trade networks. Here, we develop a forward shock-propagation model to quantify how trade flows are redistributed under a range of shock scenarios and assess the food-security outcomes by comparing changes in national fish supplies to indices of each country’s nutritional fish dependency. Shock propagation and distribution among regions are modeled on a network of historical bilateral seafood trade data from UN Comtrade using 205 reporting territories grouped into 18 regions. In our model exposure to shocks increases with total imports and the number of import partners. We find that Central and West Africa are the most vulnerable to shocks, with their vulnerability increasing when a willingness-to-pay proxy is included. These findings suggest that countries can reduce their overall vulnerability to shocks by reducing reliance on imports and diversifying food sources. As international seafood trade grows, identifying these types of potential risks and vulnerabilities is important to build a more resilient food system.

  6. Limiting Performance Analysis of Underwater Shock Isolation of a System with Biodynamic Response Using Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    Z. Zong

    2000-01-01

    Full Text Available Biodynamic response of shipboard crew to underwater shock is of a major concern to navies. An underwater shock can produce very high accelerations, resulting in severe human injuries aboard a battleship. Protection of human bodies from underwater shock is implemented by installing onboard isolators. In this paper, the optimal underwater shock isolation to protect human bodies is studied. A simple shock-structure-isolator-human interaction model is first constructed. The model incorporates the effect of fluid-structure interaction, biodynamic response of human body, isolator influence. Based on this model, the optimum shock isolation is then formulated. The performance index and restriction are defined. Thirdly, GA (genetic algorithm is employed to solve the formulated optimization problem. GA is a powerful evolutionary optimization scheme suitable for large-scale and multi-variable optimization problems that are otherwise hard to be solved by conventional methods. A brief introduction to GA is given in the paper. Finally, the method is applied to an example problem and the limiting performance characteristic is obtained.

  7. Dispersive shock waves in systems with nonlocal dispersion of Benjamin-Ono type

    Science.gov (United States)

    El, G. A.; Nguyen, L. T. K.; Smyth, N. F.

    2018-04-01

    We develop a general approach to the description of dispersive shock waves (DSWs) for a class of nonlinear wave equations with a nonlocal Benjamin-Ono type dispersion term involving the Hilbert transform. Integrability of the governing equation is not a pre-requisite for the application of this method which represents a modification of the DSW fitting method previously developed for dispersive-hydrodynamic systems of Korteweg-de Vries (KdV) type (i.e. reducible to the KdV equation in the weakly nonlinear, long wave, unidirectional approximation). The developed method is applied to the Calogero-Sutherland dispersive hydrodynamics for which the classification of all solution types arising from the Riemann step problem is constructed and the key physical parameters (DSW edge speeds, lead soliton amplitude, intermediate shelf level) of all but one solution type are obtained in terms of the initial step data. The analytical results are shown to be in excellent agreement with results of direct numerical simulations.

  8. Relativistic shocks in the systems containing domains with anomalous equation of state and quark baryonic matter hadronization

    International Nuclear Information System (INIS)

    Bugaev, K.A.; Gorenshtejn, M.I.; Zhdanov, V.I.

    1987-01-01

    Theoretical basis for general stability criterion of relativistic shocks in baryonic matter is proposed. Different formulations of shock mechanical stability are considered and applied to the analysis of rarefaction shock hadronization transition. 13 refs.; 2 figs

  9. Shock propagation in a heterogeneous medium

    International Nuclear Information System (INIS)

    Elbaz, D.

    2011-01-01

    In the frame of the inertial confinement fusion in direct drive, the use of foams as ablator allows the reduction of hydrodynamic instabilities created on the target by the direct laser irradiation. The foam is made up of carbon (CH) fibers impregnated of cryogenic deuterium-tritium (DT). In the past, studies have been carried out considering this foam to be a homogeneous medium. Yet, the foam presents heterogeneous features. We study the effects of this heterogeneity on the shock velocity when the laser irradiates the target. Thanks to experimental and numerical studies, we show that the shock propagates faster in the heterogeneous medium than in the homogeneous one with the same averaged density. This velocity gap depends on the presence rate of the CH fibers in the foam, the density ratio, the adiabatic coefficient and the foam geometry. We model the foam by different ways, more and more complex. The shock velocity modification is due to the baroclinicity which, during the interaction between the shock front and the interface, creates a vorticity deposition, responsible for the shock acceleration. Accordingly, an interface, which is plane and perpendicular to the front shock, maximizes the vorticity deposition and increases the velocity gaps between heterogeneous and homogeneous media. We found a correlation between the kinetic energy behind the shock front and the velocities relative difference. We compared our results with two analytical models. However, the system is not closed, so we can't for the moment develop a predictive model. (author) [fr

  10. MDS system increases drilling safety and efficiency

    Energy Technology Data Exchange (ETDEWEB)

    Chevallier, J.; Turner, L. (Sedco Forex, Paris (FR))

    1989-09-01

    There's a great deal of data recorded during drilling operations on rigs these days, but it is seldom well utilized. The operator's company person relies upon mud loggers for collecting and recording most information. The methods used to process and display this information are often inadequate for those who need it the most the driller and toolpusher. Drilling contractor personnel usually have only rudimentary displays of drilling parameters, and practically no serious method of analysis except for daily paper reports. These are cumbersome to use and provide only incomplete data, after the fact. The MDS system, presented in this article, is a new information and alarm network, which rectifies this situation by bringing to the rig, for the first time, the latest in sensor and computer technologies. This system acquires key drilling data on the rig floor, pump room, and return line, and displays it in a clear graphical format to both the driller and the toolpusher in real time. It also provides the toolpusher with a workstation for easy access to the same information for evaluation and planning of the drilling program.

  11. Role of heat shock protein Hsp25 in the response of the orofacial nuclei motor system to physiological stress

    Science.gov (United States)

    Murashov, A. K.; Talebian, S.; Wolgemuth, D. J.

    1998-01-01

    Although expression of the small heat shock protein family member Hsp25 has been previously observed in the central nervous system (CNS), both constitutively and upon induction, its function in the CNS remains far from clear. In the present study we have characterized the spatial pattern of expression of Hsp25 in the normal adult mouse brain as well as the changes in expression patterns induced by subjecting mice to experimental hyperthermia or hypoxia. Immunohistochemical analysis revealed a surprisingly restricted pattern of constitutive expression of Hsp25 in the brain, limited to the facial, trigeminal, ambiguus, hypoglossal and vagal motor nuclei of the brainstem. After hyperthermia or hypoxia treatment, significant increases in the levels of Hsp25 were observed in these same areas and also in fibers of the facial and trigeminal nerve tracts. Immunoblot analysis of protein lysates from brainstem also showed the same pattern of induction of Hsp25. Surprisingly, no other area in the brain showed expression of Hsp25, in either control or stressed animals. The highly restricted expression of Hsp25 implies that this protein may have a specific physiological role in the orofacial motor nuclei, which govern precise coordination between muscles of mastication and the pharynx, larynx, and face. Its rapid induction after stress further suggests that Hsp25 may serve as a specific molecular chaperone in the lower cholinergic motor neurons and along their fibers under conditions of stress or injury. Copyright 1998 Elsevier Science B.V.

  12. Integrated microelectromechanical gyroscope under shock loads

    Science.gov (United States)

    Nesterenko, T. G.; Koleda, A. N.; Barbin, E. S.

    2018-01-01

    The paper presents a new design of a shock-proof two-axis microelectromechanical gyroscope. Without stoppers, the shock load enables the interaction between the silicon sensor elements. Stoppers were installed in the gyroscope to prevent the contact interaction between electrodes and spring elements with fixed part of the sensor. The contact of stoppers occurs along the plane, thereby preventing the system from serious contact stresses. The shock resistance of the gyroscope is improved by the increase in its eigenfrequency at which the contact interaction does not occur. It is shown that the shock load directed along one axis does not virtually cause the movement of sensing elements along the crosswise axes. Maximum stresses observed in the proposed gyroscope at any loading direction do not exceed the value allowable for silicon.

  13. Shock waves and rarefaction waves in magnetohydrodynamics. Pt. 1: A model system

    International Nuclear Information System (INIS)

    Myong, R.S.; Roe, P.L.

    1997-01-01

    The present study consists of two parts. Here in Part I, a model set of conservation laws exactly preserving the MHD hyperbolic singularities is investigated to develop the general theory of the nonlinear evolution of MHD shock waves. Great emphasis is placed on shock admissibility conditions. By developing the viscosity admissibility condition, it is shown that the intermediate shocks are necessary to ensure that the planar Riemann problem is well-posed. In contrast, it turns out that the evolutionary condition is inappropriate for determining physically relevant MHD, shocks. In the general non-planar case, by studying canonical cases, we show that the solution of the Riemann problem is not necessarily unique - in particular, that it depends not only on reference states but also on the associated internal structure. Finally, the stability of intermediate shocks is discussed, and a theory of their nonlinear evolution is proposed. In Part 2, the theory of nonlinear waves developed for the model is applied to the MHD problem. It is shown that the topology of the MHD Hugoniot and wave curves is identical to that of the model problem. (Author)

  14. Resuscitation with Pooled and Pathogen-Reduced Plasma Attenuates the Increase in Brain Water Content following Traumatic Brain Injury and Hemorrhagic Shock in Rats

    DEFF Research Database (Denmark)

    Genét, Gustav Folmer; Bentzer, Peter; Ostrowski, Sisse Rye

    2017-01-01

    brain injury, hemorrhage (20 mL/kg), and 90-min shock, 48 male Sprague-Dawley rats were randomized to resuscitation with OCTA, FFP, or NS (n = 16/group). Brain water content (wet/dry weight) and BBB permeability (transfer constant for51Cr-EDTA) were measured at 24 h. Plasma osmolality, oncotic pressure......, and biomarkers of systemic glycocalyx shedding (syndecan-1) and cell damage (histone-complexed DNA) were measured at 0 and 23 h. At 24 h, brain water content was 80.44 ± 0.39%, 80.82 ± 0.82%, and 81.15 ± 0.86% in the OCTA, FFP, and NS groups (lower in OCTA vs. NS; p = 0.026), with no difference in BBB...

  15. Treatment with a histone deacetylase inhibitor, valproic acid, is associated with increased platelet activation in a large animal model of traumatic brain injury and hemorrhagic shock

    DEFF Research Database (Denmark)

    Dekker, Simone E; Sillesen, Martin; Bambakidis, Ted

    2014-01-01

    synergistic benefits. In this study, we hypothesized that VPA administration would be associated with a conservation of platelet function as measured by increased platelet activation after resuscitation. MATERIALS AND METHODS: Ten swine (42-50 kg) were subjected to TBI and HS (40% blood loss). Animals were...... neuroprotective effects of VPA may be due to a conservation of platelet function as measured by a higher platelet activation response after resuscitation....... left in shock for 2 h before resuscitation with either FFP or FFP + VPA (300 mg/kg). Serum levels of platelet activation markers transforming growth factor beta, CD40 L, P-selectin, and platelet endothelial cell adhesion molecule (PECAM) 1 were measured at baseline, postresuscitation, and after a 6-h...

  16. The Transcriptional Heat Shock Response of Salmonella Typhimurium Shows Hysteresis and Heated Cells Show Increased Resistance to Heat and Acid Stress

    DEFF Research Database (Denmark)

    Pin, C.; Hansen, Trine; Munoz-Cuevas, M.

    2012-01-01

    We investigated if the transcriptional response of Salmonella Typhimurium to temperature and acid variations was hysteretic, i.e. whether the transcriptional regulation caused by environmental stimuli showed memory and remained after the stimuli ceased. The transcriptional activity of non......, implying that down-regulation was significantly less synchronized than upregulation. The hysteretic transcriptional response to heat shock was accompanied by higher resistance to inactivation at 50uC as well as cross-resistance to inactivation at pH 3; however, growth rates and lag times at 43uC and at p......H 4.5 were not affected. The exposure to pH 5 only caused up-regulation of 12 genes and this response was neither hysteretic nor accompanied of increased resistance to inactivation conditions. Cellular memory at the transcriptional level may represent a mechanism of adaptation to the environment...

  17. Permeability enhancement by shock cooling

    Science.gov (United States)

    Griffiths, Luke; Heap, Michael; Reuschlé, Thierry; Baud, Patrick; Schmittbuhl, Jean

    2015-04-01

    The permeability of an efficient reservoir, e.g. a geothermal reservoir, should be sufficient to permit the circulation of fluids. Generally speaking, permeability decreases over the life cycle of the geothermal system. As a result, is usually necessary to artificially maintain and enhance the natural permeability of these systems. One of the methods of enhancement -- studied here -- is thermal stimulation (injecting cold water at low pressure). This goal of this method is to encourage new thermal cracks within the reservoir host rocks, thereby increasing reservoir permeability. To investigate the development of thermal microcracking in the laboratory we selected two granites: a fine-grained (Garibaldi Grey granite, grain size = 0.5 mm) and a course-grained granite (Lanhelin granite, grain size = 2 mm). Both granites have an initial porosity of about 1%. Our samples were heated to a range of temperatures (100-1000 °C) and were either cooled slowly (1 °C/min) or shock cooled (100 °C/s). A systematic microstructural (2D crack area density, using standard stereological techniques, and 3D BET specific surface area measurements) and rock physical property (porosity, P-wave velocity, uniaxial compressive strength, and permeability) analysis was undertaken to understand the influence of slow and shock cooling on our reservoir granites. Microstructurally, we observe that the 2D crack surface area per unit volume and the specific surface area increase as a result of thermal stressing, and, for the same maximum temperature, crack surface area is higher in the shock cooled samples. This observation is echoed by our rock physical property measurements: we see greater changes for the shock cooled samples. We can conclude that shock cooling is an extremely efficient method of generating thermal microcracks and modifying rock physical properties. Our study highlights that thermal treatments are likely to be an efficient method for the "matrix" permeability enhancement of

  18. Is modification of the VVI backup mode in implantable cardioverter-defibrillators from St Jude medical required due to increased risk of inappropriate shocks?

    DEFF Research Database (Denmark)

    Philbert, Berit Thornvig; Tfelt-Hansen, Jacob; Jacobsen, Peter K

    2017-01-01

    Inappropriate implantable cardioverter-defibrillator (ICD) shock therapy is painful, stressful, and typically occurs unexpected in conscious patients and may be related to a less favourable prognosis. In our institution, we have observed four cases of multiple inappropriate ICD shocks during reset...... a ventricular fibrillation (VF) zone starting at 146 b.p.m., with shock therapy only and changes in sensitivity settings making the ICD more sensitive. In all cases, the reason for the multiple inappropriate shocks was that the VF zone was reached due to exercise-induced sinus tachycardia or due to oversensing...... during sinus rhythm. The VVI backup mode has to balance between protection from failure of ICD therapy during life-threatening ventricular arrhythmias and from inappropriate shocks. It seems the non-programmable parameters in VVI backup mode of St Jude Medical ICDs carry an unacceptable high risk...

  19. Shock absorber

    International Nuclear Information System (INIS)

    Nemeth, J.D.

    1981-01-01

    A shock absorber for the support of piping and components in a nuclear power plant is described. It combines a high degree of stiffness under sudden shocks, e.g. seismic disturbances, with the ability to allow for thermal expansion without resistance when so required. (JIW)

  20. ANAPHYLACTOID SHOCK FOLLOWING HYMENOPTERA STING AS A PRESENTING SYMPTOM OF SYSTEMIC MASTOCYTOSIS

    NARCIS (Netherlands)

    KORS, JW; VANDOORMAAL, JJ; DEMONCHY, JGR

    Systemic mastocytosis is a rare and chronic disorder characterized by a pathologically increased number of mast cells in various tissues and overproduction of mast cell mediators. From a group of 1 5 patients (I 0 females, 5 males) with systemic mastocytosis five female patients presented with a

  1. Biology of the Heat Shock Response and Protein Chaperones: Budding Yeast (Saccharomyces cerevisiae) as a Model System

    Science.gov (United States)

    Verghese, Jacob; Abrams, Jennifer; Wang, Yanyu

    2012-01-01

    Summary: The eukaryotic heat shock response is an ancient and highly conserved transcriptional program that results in the immediate synthesis of a battery of cytoprotective genes in the presence of thermal and other environmental stresses. Many of these genes encode molecular chaperones, powerful protein remodelers with the capacity to shield, fold, or unfold substrates in a context-dependent manner. The budding yeast Saccharomyces cerevisiae continues to be an invaluable model for driving the discovery of regulatory features of this fundamental stress response. In addition, budding yeast has been an outstanding model system to elucidate the cell biology of protein chaperones and their organization into functional networks. In this review, we evaluate our understanding of the multifaceted response to heat shock. In addition, the chaperone complement of the cytosol is compared to those of mitochondria and the endoplasmic reticulum, organelles with their own unique protein homeostasis milieus. Finally, we examine recent advances in the understanding of the roles of protein chaperones and the heat shock response in pathogenic fungi, which is being accelerated by the wealth of information gained for budding yeast. PMID:22688810

  2. Increased circulating heat shock protein 70 (HSPA1A) levels in gestational diabetes mellitus: a pilot study.

    Science.gov (United States)

    Garamvölgyi, Zoltán; Prohászka, Zoltán; Rigó, János; Kecskeméti, András; Molvarec, Attila

    2015-07-01

    Recent data indicate that serum Hsp70 (HSPA1A) levels are increased in type 1 and 2 diabetes mellitus. However, there is no report in the literature on circulating Hsp70 levels in gestational diabetes mellitus. In this pilot study, we measured serum Hsp70 levels in 11 pregnant women with pregestational diabetes, 38 women with gestational diabetes, and 40 healthy pregnant women with ELISA. Plasma glucose levels, serum insulin concentrations, HbA1c values, and the Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) index were also determined. According to our results, serum Hsp70 concentrations were significantly higher in women with pregestational and gestational diabetes mellitus than in healthy pregnant women. In addition, pregestational diabetic women had significantly higher Hsp70 levels than those with gestational diabetes. Furthermore, in the group of women with gestational diabetes mellitus, serum Hsp70 levels showed a significant positive correlation with HbA1c values. However, there was no other relationship between clinical features and metabolic parameters of the study subjects and their serum Hsp70 levels in either study group. In conclusion, we demonstrated for the first time in the literature that serum Hsp70 levels are increased and correlate with HbA1c values in women with gestational diabetes mellitus. Nevertheless, further studies are needed to determine whether circulating Hsp70 plays a causative role in the pathogenesis of gestational diabetes or elevated serum Hsp70 levels are only consequences of the disease.

  3. Collisionless shock waves

    International Nuclear Information System (INIS)

    Sagdeev, R.Z.; Kennel, C.F.

    1991-01-01

    Collisionless shocks cannot occur naturally on the earth, because nearly all matter here consists of electrically neutral atoms and molecules. In space, however, high temperatures and ultraviolet radiation from hot stars decompose atoms into their constituent nuclei and electrons, producing a soup of electrically charged particles known as a plasma. Plasma physicists proposed that the collective electrical and magnetic properties of plasmas could produce interactions that take the place of collisions and permit shocks to form. In 1964 the theoretical work found its first experimental confirmation. Norman F. Ness and his colleagues at the Goddard Space Flight Center, using data collected from the iMP-1 spacecraft, detected clear signs that a collisionless shock exists where the solar wind encounters the earth's magnetic field. More recent research has demonstrated that collisionless shocks appear in a dazzling array of astronomical settings. For example, shocks have been found in the solar wind upstream (sunward) of all the planet and comets that have been visited by spacecraft. Violent flares on the sun generate shocks that propagate to the far reaches of the solar system; tremendous galactic outbursts create disruptions in the intergalactic medium that are trillions of times larger. In addition, many astrophysicists think that shocks from supernova explosions in our galaxy accelerate cosmic rays, a class of extraordinarily energetic elementary particles and atomic nuclei that rain down on the earth from all directions

  4. Elevated CO2 increases R gene-dependent resistance of Medicago truncatula against the pea aphid by up-regulating a heat shock gene.

    Science.gov (United States)

    Sun, Yucheng; Guo, Huijuan; Yuan, Erliang; Ge, Feng

    2018-03-01

    Resistance against pathogens and herbivorous insects in many plant results from the expression of resistance (R) genes. Few reports, however, have considered the effects of elevated CO 2 on R gene-based resistance in plants. The current study determined the responses of two near isogenic Medicago truncatula genotypes (Jester has an R gene and A17 does not) to the pea aphid and elevated CO 2 in open-top chambers in the field. Aphid abundance, mean relative growth rate and feeding efficiency were increased by elevated CO 2 on A17 plants but were reduced on Jester plants. According to proteomic and gene expression data, elevated CO 2 enhanced pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) but decreased the effector-triggered immunity (ETI) in aphid-infested A17 plants. For aphid-infested Jester plants, by contrast, elevated CO 2 enhanced the ETI-related heat shock protein (HSP) 90 and its co-chaperones, the jasmonic acid (JA) signaling pathway, and ubiquitin-mediated proteolysis. In a loss-of-function experiment, silencing of the HSP90 gene in Jester plants impaired the JA signaling pathway and ubiquitin-mediated proteolysis against the aphid under ambient CO 2 , and negated the increased resistance against the aphid under elevated CO 2 . Our results suggest that increases in expression of HSP90 are responsible for the enhanced resistance against the aphid under elevated CO 2 . © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

  5. Increases of heat shock proteins and their mRNAs at high hydrostatic pressure in a deep-sea piezophilic bacterium, Shewanella violacea.

    Science.gov (United States)

    Sato, Hiroshi; Nakasone, Kaoru; Yoshida, Takao; Kato, Chiaki; Maruyama, Tadashi

    2015-07-01

    When non-extremophiles encounter extreme environmental conditions, which are natural for the extremophiles, stress reactions, e.g., expression of heat shock proteins (HSPs), are thought to be induced for survival. To understand how the extremophiles live in such extreme environments, we studied the effects of high hydrostatic pressure on cellular contents of HSPs and their mRNAs during growth in a piezophilic bacterium, Shewanella violacea. HSPs increased at high hydrostatic pressures even when optimal for growth. The mRNAs and proteins of these HSPs significantly increased at higher hydrostatic pressure in S. violacea. In the non-piezophilic Escherichia coli, however, their mRNAs decreased, while their proteins did not change. Several transcriptional start sites (TSSs) for HSP genes were determined by the primer extension method and some of them showed hydrostatic pressure-dependent increase of the mRNAs. A major refolding target of one of the HSPs, chaperonin, at high hydrostatic pressure was shown to be RplB, a subunit of the 50S ribosome. These results suggested that in S. violacea, HSPs play essential roles, e.g., maintaining protein complex machinery including ribosomes, in the growth and viability at high hydrostatic pressure, and that, in their expression, the transcription is under the control of σ(32).

  6. demystifying the shock of shocking

    African Journals Online (AJOL)

    (with a pulse), atrial fibrillation and atrial flutter. The energy dose in cardioversion is less (0.5. - 2 J/kg) than in defibrillation (2 - 4 J/kg). In cardioversion the shock is discharged synchronously with the native R wave of the patient. Without synchronisation,. VF can be induced if a shock is delivered during the refractory period ...

  7. The hack attack - Increasing computer system awareness of vulnerability threats

    Science.gov (United States)

    Quann, John; Belford, Peter

    1987-01-01

    The paper discusses the issue of electronic vulnerability of computer based systems supporting NASA Goddard Space Flight Center (GSFC) by unauthorized users. To test the security of the system and increase security awareness, NYMA, Inc. employed computer 'hackers' to attempt to infiltrate the system(s) under controlled conditions. Penetration procedures, methods, and descriptions are detailed in the paper. The procedure increased the security consciousness of GSFC management to the electronic vulnerability of the system(s).

  8. Optimal control of transient processes in an oscillating system with an electrorheological shock-absorber

    Energy Technology Data Exchange (ETDEWEB)

    Reizina, G N [National Technical University, 65 Nezavisimosti Avenue, Minsk, 220013 (Belarus); Korobko, E V; Bilyk, V A [Luikov Heat and Mass Transfer Institute of NASB, 15 P Brovki Street, Minsk, 220072 (Belarus); Efremov, V L; Binshtok, A E [Minsk Wheel Tractor Plant, 150 Partizanskii Avenue, Minsk, 220021 (Belarus)], E-mail: eva@itmo.by

    2009-02-01

    The problem of optimal control of the oscillation of a driver's seat with ER shock absorber is discussed in application to vehicles based on the principle of maximum. Coordinates of a vector of the control parameter and vertical motions of a seat are obtained. Test experimental investigations on working regimes for the driver's seat model depending on the controlling impact of the electrical signal (the intensity of the electric field) were performed.

  9. Life shocks and homelessness.

    Science.gov (United States)

    Curtis, Marah A; Corman, Hope; Noonan, Kelly; Reichman, Nancy E

    2013-12-01

    We exploited an exogenous health shock-namely, the birth of a child with a severe health condition-to investigate the effect of a life shock on homelessness in large cities in the United States as well as the interactive effects of the shock with housing market characteristics. We considered a traditional measure of homelessness, two measures of housing instability thought to be precursors to homelessness, and a combined measure that approximates the broadened conceptualization of homelessness under the 2009 Homeless Emergency Assistance and Rapid Transition to Housing Act (2010). We found that the shock substantially increases the likelihood of family homelessness, particularly in cities with high housing costs. The findings are consistent with the economic theory of homelessness, which posits that homelessness results from a conjunction of adverse circumstances in which housing markets and individual characteristics collide.

  10. Method and System for Weakening Shock Wave Strength at Leading Edge Surfaces of Vehicle in Supersonic Atmospheric Flight

    Science.gov (United States)

    Daso, Endwell O. (Inventor); Pritchett, Victor E., II (Inventor); Wang, Ten-See (Inventor); Farr, Rebecca Ann (Inventor); Auslender, Aaron Howard (Inventor); Blankson, Isaiah M. (Inventor); Plotkin, Kenneth J. (Inventor)

    2015-01-01

    A method and system are provided to weaken shock wave strength at leading edge surfaces of a vehicle in atmospheric flight. One or more flight-related attribute sensed along a vehicle's outer mold line are used to control the injection of a non-heated, non-plasma-producing gas into a local external flowfield of the vehicle from at least one leading-edge surface location along the vehicle's outer mold line. Pressure and/or mass flow rate of the gas so-injected is adjusted in order to cause a Rankine-Hugoniot Jump Condition along the vehicle's outer mold line to be violated.

  11. Plasma Concentration of Biomarkers Reflecting Endothelial Cell- and Glycocalyx Damage are Increased in Patients with Suspected St-Elevation Myocardial Infarction Complicated by Cardiogenic Shock

    DEFF Research Database (Denmark)

    Frydland, Martin; Ostrowski, Sisse Rye; Møller, Jacob Eifer

    2018-01-01

    BACKGROUND: Mortality in ST-elevation myocardial infarction (STEMI)-patients developing cardiogenic shock (CS) during hospitalization is high. Catecholamines, ischemia, and inflammation (parameters present in CS) affect the endothelium. We hypothesized that plasma level of biomarkers reflecting e...

  12. Hypovolemic shock

    Science.gov (United States)

    ... the person's position unless they are in immediate danger. Do not give fluids by mouth. If person ... the patient with shock. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine . 25th ed. Philadelphia, PA: ...

  13. Shock absorber

    International Nuclear Information System (INIS)

    Housman, J.J.

    1978-01-01

    A shock absorber is described for use in a hostile environment at the end of a blind passage for absorbing impact loads. The shock absorber includes at least one element which occupies the passage and which is comprised of a porous brittle material which is substantially non-degradable in the hostile environment. A void volume is provided in the element to enable the element to absorb a predetermined level of energy upon being crushed due to impact loading

  14. Radiation- and pair-loaded shocks

    Science.gov (United States)

    Lyutikov, Maxim

    2018-06-01

    We consider the structure of mildly relativistic shocks in dense media, taking into account the radiation and pair loading, and diffusive radiation energy transfer within the flow. For increasing shock velocity (increasing post-shock temperature), the first important effect is the efficient energy redistribution by radiation within the shock that leads to the appearance of an isothermal jump, whereby the flow reaches the final state through a discontinuous isothermal transition. The isothermal jump, on scales much smaller than the photon diffusion length, consists of a weak shock and a quick relaxation to the isothermal conditions. Highly radiation-dominated shocks do not form isothermal jump. Pair production can mildly increase the overall shock compression ratio to ≈10 (4 for matter-dominated shocks and 7 of the radiation-dominated shocks).

  15. Activated protein C plays no major roles in the inhibition of coagulation or increased fibrinolysis in acute coagulopathy of trauma-shock: a systematic review.

    Science.gov (United States)

    Gando, Satoshi; Mayumi, Toshihiko; Ukai, Tomohiko

    2018-01-01

    The pathophysiological mechanisms of acute coagulopathy of trauma-shock (ACOTS) are reported to include activated protein C-mediated suppression of thrombin generation via the proteolytic inactivation of activated Factor V (FVa) and FVIIIa; an increased fibrinolysis via neutralization of plasminogen activator inhibitor-1 (PAI-1) by activated protein C. The aims of this study are to review the evidences for the role of activated protein C in thrombin generation and fibrinolysis and to validate the diagnosis of ACOTS based on the activated protein C dynamics. We conducted systematic literature search (2007-2017) using PubMed, the Cochrane Database of Systematic Reviews (CDSR), and the Cochrane Central Register of Controlled Trials (CENTRAL). Clinical studies on trauma that measured activated protein C or the circulating levels of activated protein C-related coagulation and fibrinolysis markers were included in our study. Out of 7613 studies, 17 clinical studies met the inclusion criteria. The levels of activated protein C in ACOTS were inconsistently decreased, showed no change, or were increased in comparison to the control groups. Irrespective of the activated protein C levels, thrombin generation was always preserved or highly elevated. There was no report on the activated protein C-mediated neutralization of PAI-1 with increased fibrinolysis. No included studies used unified diagnostic criteria to diagnose ACOTS and those studies also used different terms to refer to the condition known as ACOTS. None of the studies showed direct cause and effect relationships between activated protein C and the suppression of coagulation and increased fibrinolysis. No definitive diagnostic criteria or unified terminology have been established for ACOTS based on the activated protein C dynamics.

  16. Control Volume Analysis of Boundary Layer Ingesting Propulsion Systems With or Without Shock Wave Ahead of the Inlet

    Science.gov (United States)

    Kim, Hyun Dae; Felder, James L.

    2011-01-01

    The performance benefit of boundary layer or wake ingestion on marine and air vehicles has been well documented and explored. In this article, a quasi-one-dimensional boundary layer ingestion (BLI) benefit analysis for subsonic and transonic propulsion systems is performed using a control volume of a ducted propulsion system that ingests the boundary layer developed by the external airframe surface. To illustrate the BLI benefit, a relationship between the amount of BLI and the net thrust is established and analyzed for two propulsor types. One propulsor is an electric fan, and the other is a pure turbojet. These engines can be modeled as a turbofan with an infinite bypass ratio for the electric fan, and with a zero bypass ratio for the pure turbojet. The analysis considers two flow processes: a boundary layer being ingested by an aircraft inlet and a shock wave sitting in front of the inlet. Though the two processes are completely unrelated, both represent a loss of total pressure and velocity. In real applications, it is possible to have both processes occurring in front of the inlet of a transonic vehicle. Preliminary analysis indicates that the electrically driven propulsion system benefits most from the boundary layer ingestion and the presence of transonic shock waves, whereas the benefit for the turbojet engine is near zero or negative depending on the amount of total temperature rise across the engine.

  17. Pifithrin-μ, an inhibitor of heat-shock protein 70, can increase the antitumor effects of hyperthermia against human prostate cancer cells.

    Directory of Open Access Journals (Sweden)

    Kazumasa Sekihara

    Full Text Available Hyperthermia (HT improves the efficacy of anti-cancer radiotherapy and chemotherapy. However, HT also inevitably evokes stress responses and increases the expression of heat-shock proteins (HSPs in cancer cells. Among the HSPs, HSP70 is known as a pro-survival protein. In this study, we investigated the sensitizing effect of pifithrin (PFT-μ, a small molecule inhibitor of HSP70, when three human prostate cancer cell lines (LNCaP, PC-3, and DU-145 were treated with HT (43°C for 2 h. All cell lines constitutively expressed HSP70, and HT further increased its expression in LNCaP and DU-145. Knockdown of HSP70 with RNA interference decreased the viability and colony-forming ability of cancer cells. PFT-μ decreased the viabilities of all cell lines at one-tenth the dose of Quercetin, a well-known HSP inhibitor. The combination therapy with suboptimal doses of PFT-μ and HT decreased the viability of cancer cells most effectively when PFT-μ was added immediately before HT, and this combination effect was abolished by pre-knockdown of HSP70, suggesting that the effect was mediated via HSP70 inhibition. The combination therapy induced cell death, partially caspase-dependent, and decreased proliferating cancer cells, with decreased expression of c-Myc and cyclin D1 and increased expression of p21(WAF1/Cip, indicating arrest of cell growth. Additionally, the combination therapy significantly decreased the colony-forming ability of cancer cells compared to therapy with either alone. Furthermore, in a xenograft mouse model, the combination therapy significantly inhibited PC-3 tumor growth. These findings suggest that PFT-μ can effectively enhance HT-induced antitumor effects via HSP70 inhibition by inducing cell death and arrest of cell growth, and that PFT-μ is a promising agent for use in combination with HT to treat prostate cancer.

  18. Age-Related Decrease in Heat Shock 70-kDa Protein 8 in Cerebrospinal Fluid Is Associated with Increased Oxidative Stress.

    Science.gov (United States)

    Loeffler, David A; Klaver, Andrea C; Coffey, Mary P; Aasly, Jan O; LeWitt, Peter A

    2016-01-01

    Age-associated declines in protein homeostasis mechanisms ("proteostasis") are thought to contribute to age-related neurodegenerative disorders. The increased oxidative stress which occurs with aging can activate a key proteostatic process, chaperone-mediated autophagy. This study investigated age-related alteration in cerebrospinal fluid (CSF) concentrations of heat shock 70-kDa protein 8 (HSPA8), a molecular chaperone involved in proteostatic mechanisms including chaperone-mediated autophagy, and its associations with indicators of oxidative stress (8-hydroxy-2'-deoxyguanosine [8-OHdG] and 8-isoprostane) and total anti-oxidant capacity. We examined correlations between age, HSPA8, 8-OHdG, 8-isoprostane, and total antioxidant capacity (TAC) in CSF samples from 34 healthy subjects ranging from 20 to 75 years of age. Age was negatively associated with HSPA8 (ρ = -0.47; p = 0.005). An age-related increase in oxidative stress was indicated by a positive association between age and 8-OHdG (ρ = 0.61; p = 0.0001). HSPA8 was moderately negatively associated with 8-OHdG (ρ = -0.58; p = 0.0004). Age and HSPA8 were weakly associated with 8-isoprostane and TAC (range of ρ values: -0.15 to 0.16). Our findings in this exploratory study suggest that during healthy aging, CSF HSPA8 may decrease, perhaps due in part to an increase in oxidative stress. Our results also suggest that 8-OHdG may be more sensitive than 8-isoprostane for measuring oxidative stress in CSF. Further studies are indicated to determine if our findings can be replicated with a larger cohort, and if the age-related decrease in HSPA8 in CSF is reflected by a similar change in the brain.

  19. An array-based study of increased system lifetime probability

    DEFF Research Database (Denmark)

    Nesgaard, Carsten

    2003-01-01

    Society's increased dependence on electronic systems calls for highly reliable power supplies comprised of multiple converters working in parallel. This paper describes a redundancy control scheme, based on the array technology that increases the overall reliability quite considerably and thereby...

  20. An array-based study of increased system lifetime probability

    DEFF Research Database (Denmark)

    Nesgaard, Carsten

    2002-01-01

    Society's increased dependence on electronic systems calls for highly reliable power supplies comprised of multiple converters working in parallel. This paper describes a redundancy control scheme, based on the array technology that increases the overall reliability quite considerably and thereby...

  1. Selfsimilar time dependent shock structures

    International Nuclear Information System (INIS)

    Beck, R.; Drury, L.O.

    1985-01-01

    Diffusive shock acceleration as an astrophysical mechanism for accelerating charged particles has the advantage of being highly efficient. This means however that the theory is of necessity nonlinear; the reaction of the accelerated particles on the shock structure and the acceleration process must be self-consistently included in any attempt to develop a complete theory of diffusive shock acceleration. Considerable effort has been invested in attempting, at least partially, to do this and it has become clear that in general either the maximum particle energy must be restricted by introducing additional loss processes into the problem or the acceleration must be treated as a time dependent problem (Drury, 1984). It is concluded that stationary modified shock structures can only exist for strong shocks if additional loss processes limit the maximum energy a particle can attain. This is certainly possible and if it occurs the energy loss from the shock will lead to much greater shock compressions. It is however equally possible that no such processes exist and we must then ask what sort of nonstationary shock structure develops. The same argument which excludes stationary structures also rules out periodic solutions and indeed any solution where the width of the shock remains bounded. It follows that the width of the shock must increase secularly with time and it is natural to examine the possibility of selfsimilar time dependent solutions

  2. Selfsimilar time dependent shock structures

    Science.gov (United States)

    Beck, R.; Drury, L. O.

    1985-01-01

    Diffusive shock acceleration as an astrophysical mechanism for accelerating charged particles has the advantage of being highly efficient. This means however that the theory is of necessity nonlinear; the reaction of the accelerated particles on the shock structure and the acceleration process must be self-consistently included in any attempt to develop a complete theory of diffusive shock acceleration. Considerable effort has been invested in attempting, at least partially, to do this and it has become clear that in general either the maximum particle energy must be restricted by introducing additional loss processes into the problem or the acceleration must be treated as a time dependent problem (Drury, 1984). It is concluded that stationary modified shock structures can only exist for strong shocks if additional loss processes limit the maximum energy a particle can attain. This is certainly possible and if it occurs the energy loss from the shock will lead to much greater shock compressions. It is however equally possible that no such processes exist and we must then ask what sort of nonstationary shock structure develops. The ame argument which excludes stationary structures also rules out periodic solutions and indeed any solution where the width of the shock remains bounded. It follows that the width of the shock must increase secularly with time and it is natural to examine the possibility of selfsimilar time dependent solutions.

  3. Disposable self-support paper-based multi-anode microbial fuel cell (PMMFC) integrated with power management system (PMS) as the real time "shock" biosensor for wastewater.

    Science.gov (United States)

    Xu, Zhiheng; Liu, Yucheng; Williams, Isaiah; Li, Yan; Qian, Fengyu; Zhang, Hui; Cai, Dingyi; Wang, Lei; Li, Baikun

    2016-11-15

    A paper-based multi-anode microbial fuel cell (PMMFC) integrated with power management system (PMS) was developed as a disposable self-support real-time "shock" biosensor for wastewater. PMMFCs were examined at three types of shocks (chromium, hypochlorite and acetate) in a batch-mode chamber, and exhibited various responses to shock types and concentrations. The power output of PMMFC sensor was four times as the carbon cloth (CC)-based MFCs, indicating the advantage of paper-based anode for bacterial adhesion. The power output was more sensitive than the voltage output under shocks, and thus preventing the false signals. The simulation of power harvest using PMS indicated that PMMFC could accomplish more frequent data transmission than single-anode MFCs (PSMFC) and CC anode MFCs (CCMMFC), making the self-support wastewater monitor and data transmission possible. Compared with traditional MFC sensors, PMMFCs integrated with PMS exhibit the distinct advantages of tight paper-packed structure, short acclimation period, high power output, and high sensitivity to a wide range of shocks, posing a great potential as "disposable self-support shock sensor" for real time in situ monitoring of wastewater quality. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. Biophoton emission induced by heat shock.

    Directory of Open Access Journals (Sweden)

    Katsuhiro Kobayashi

    Full Text Available Ultraweak biophoton emission originates from the generation of reactive oxygen species (ROS that are produced in mitochondria as by-products of cellular respiration. In healthy cells, the concentration of ROS is minimized by a system of biological antioxidants. However, heat shock changes the equilibrium between oxidative stress and antioxidant activity, that is, a rapid rise in temperature induces biophoton emission from ROS. Although the rate and intensity of biophoton emission was observed to increase in response to elevated temperatures, pretreatment at lower high temperatures inhibited photon emission at higher temperatures. Biophoton measurements are useful for observing and evaluating heat shock.

  5. Systemic Liquidity Shocks and Banking Sector Liquidity Characteristics on the Eve of Liquidity Coverage Ratio Application - The Case of the Czech Republic1

    Directory of Open Access Journals (Sweden)

    Brůna Karel

    2016-01-01

    Full Text Available The paper contains an analysis of the economic and regulatory concept of bank liquidity in the context of systemic liquidity shock. A formal model analysis shows that the application of liquidity coverage ratio (LCR based on Basel III will lead to a significant adaptation of banks liquidity management. LCR causes a change in bank’s liquidity allocation and funding to be less effective and more costly and restrictive for providing credits comparing with economic determinants. It is demonstrated that the application of LCR underestimates actual liquidity position of a bank and leads to allocation ineffectiveness. The empirical part contains simulation of impacts of systemic liquidity shock on the banking sector’s ability to withstand the unfavourable credit shock while solvency is maintained. The results confirm the robustness of the Czech banking system ensuing from the systemic surplus of liquidity, high volume of bank capital and its high profitability. The estimations of the VAR model show that the relations between liquidity characteristics of banks, sources of aggregate liquidity shock, interbank market illiquidity and the credit facilities of the Czech National Bank are relatively weak, supporting the conclusion that the banks face liquidity shocks of non-persistent character.

  6. Effects of explosion-generated shock waves in ducts

    International Nuclear Information System (INIS)

    Busby, M.R.; Kahn, J.E.; Belk, J.P.

    1976-01-01

    An explosion in a space causes an increase in temperature and pressure. To quantify the challenge that will be presented to essential components in a ventilation system, it is necessary to analyze the dynamics of a shock wave generated by an explosion, with attention directed to the propagation of such a wave in a duct. Using the equations of unsteady flow and shock tube theory, a theoretical model has been formulated to provide flow properties behind moving shock waves that have interacted with various changes in duct geometry. Empirical equations have been derived to calculate air pressure, temperature, Mach number, and velocity in a duct following an explosion

  7. Systems for increasing the sensitivity of gamma-ray imagers

    Science.gov (United States)

    Mihailescu, Lucian; Vetter, Kai M.; Chivers, Daniel H.

    2012-12-11

    Systems that increase the position resolution and granularity of double sided segmented semiconductor detectors are provided. These systems increase the imaging resolution capability of such detectors, either used as Compton cameras, or as position sensitive radiation detectors in imagers such as SPECT, PET, coded apertures, multi-pinhole imagers, or other spatial or temporal modulated imagers.

  8. Health shocks and risk aversion.

    Science.gov (United States)

    Decker, Simon; Schmitz, Hendrik

    2016-12-01

    We empirically assess whether a health shock influences individual risk aversion. We use grip strength data to obtain an objective health shock indicator. In order to account for the non-random nature of our data regression-adjusted matching is employed. Risk preferences are traditionally assumed to be constant. However, we find that a health shock increases individual risk aversion. The finding is robust to a series of sensitivity analyses and persists for at least four years after the shock. Income changes do not seem to be the driving mechanism. Copyright © 2016 Elsevier B.V. All rights reserved.

  9. Shock in the emergency department

    DEFF Research Database (Denmark)

    Holler, Jon Gitz; Henriksen, Daniel Pilsgaard; Mikkelsen, Søren

    2016-01-01

    BACKGROUND: The knowledge of the frequency and associated mortality of shock in the emergency department (ED) is limited. The aim of this study was to describe the incidence, all-cause mortality and factors associated with death among patients suffering shock in the ED. METHODS: Population...... failures. Outcomes were annual incidence per 100,000 person-years at risk (pyar), all-cause mortality at 0-7, and 8-90 days and risk factors associated with death. RESULTS: We identified 1646 of 438,191 (0.4 %) ED patients with shock at arrival. Incidence of shock increased from 53.8 to 80.6 cases per 100...

  10. Increase of COP for heat transformer in water purification systems. Part I - Increasing heat source temperature

    International Nuclear Information System (INIS)

    Siqueiros, J.; Romero, R.J.

    2007-01-01

    The integration of a water purification system in a heat transformer allows a fraction of heat obtained by the heat transformer to be recycled, increasing the heat source temperature. Consequently, the evaporator and generator temperatures are also increased. For any operating conditions, keeping the condenser and absorber temperatures and also the heat load to the evaporator and generator, a higher value of COP is obtained when only the evaporator and generator temperatures are increased. Simulation with proven software compares the performance of the modeling of an absorption heat transformer for water purification (AHTWP) operating with water/lithium bromide, as the working fluid-absorbent pair. Plots of enthalpy-based coefficients of performance (COP ET ) and the increase in the coefficient of performance (COP) are shown against absorber temperature for several thermodynamic operating conditions. The results showed that proposed (AHTWP) system is capable of increasing the original value of COP ET more than 120%, by recycling part of the energy from a water purification system. The proposed system allows to increase COP values from any experimental data for water purification or any other distillation system integrated to a heat transformer, regardless of the actual COP value and any working fluid-absorbent pair

  11. New degradation call admission control for increasing WCDMA system capacity

    Institute of Scientific and Technical Information of China (English)

    Liu Ningqing; Lu Zhi; Gu Xuemai

    2006-01-01

    Propose a new degradation call admission control(DCAC)scheme, which can be used in wideband code division multiple access communication system. So-called degradation is that non-real time call has the characteristic of variable bit rate, so decreasing its bit rate can reduce the load of the system, consequently the system can admit new call which should be blocked when the system is close to full load, therefore new call's access probability increases. This paper brings forward design project and does system simulation, simulation proves that DCAC can effectively decrease calls' blocking probability and increase the total number of the on-line users.

  12. Modeling the Motion of an Increasing Mass System

    Science.gov (United States)

    Kunkel, William; Harrington, Randal

    2010-01-01

    Problems on the dynamics of changing mass systems often call for the more general form of Newton's second law Fnet = dp/dt. These problems usually involve situations where the mass of the system decreases, such as in rocket propulsion. In contrast, this experiment examines a system where the mass "increases" at a constant rate and the net force…

  13. Uniform shock waves in disordered granular matter.

    Science.gov (United States)

    Gómez, Leopoldo R; Turner, Ari M; Vitelli, Vincenzo

    2012-10-01

    The confining pressure P is perhaps the most important parameter controlling the properties of granular matter. Strongly compressed granular media are, in many respects, simple solids in which elastic perturbations travel as ordinary phonons. However, the speed of sound in granular aggregates continuously decreases as the confining pressure decreases, completely vanishing at the jamming-unjamming transition. This anomalous behavior suggests that the transport of energy at low pressures should not be dominated by phonons. In this work we use simulations and theory to show how the response of granular systems becomes increasingly nonlinear as pressure decreases. In the low-pressure regime the elastic energy is found to be mainly transported through nonlinear waves and shocks. We numerically characterize the propagation speed, shape, and stability of these shocks and model the dependence of the shock speed on pressure and impact intensity by a simple analytical approach.

  14. How do health workers experience and cope with shocks? Learning from four fragile and conflict-affected health systems in Uganda, Sierra Leone, Zimbabwe and Cambodia.

    Science.gov (United States)

    Witter, Sophie; Wurie, Haja; Chandiwana, Pamela; Namakula, Justine; So, Sovannarith; Alonso-Garbayo, Alvaro; Ssengooba, Freddie; Raven, Joanna

    2017-11-01

    This article is grounded in a research programme which set out to understand how to rebuild health systems post-conflict. Four countries were studied-Uganda, Sierra Leone, Zimbabwe and Cambodia-which were at different distances from conflict and crisis, as well as having unique conflict stories. During the research process, the Ebola epidemic broke out in West Africa. Zimbabwe has continued to face a profound economic crisis. Within our research on health worker incentives, we captured insights from 128 life histories and in-depth interviews with a variety of staff that had remained in service. This article aims to draw together lessons from these contexts which can provide lessons for enhancing staff and therefore health system resilience in future, especially in similarly fragile and conflict-affected contexts. We examine the reported effects, both personal and professional, of the three different types of shock (conflicts, epidemics and prolonged political-economic crises), and how staff coped. We find that the impact of shocks and coping strategies are similar between conflict/post-conflict and epidemic contexts-particularly in relation to physical threats and psychosocial threats-while all three contexts create challenges and staff responses for working conditions and remuneration. Health staff showed considerable inventiveness and resilience, and also benefited from external assistance of various kinds, but there are important gaps which point to ways in which they should be better protected and supported in the future. Health systems are increasingly fragile and conflict-prone, and shocks are often prolonged or repeated. Resilience should not be taken for granted or used as an excuse for abandoning frontline health staff. Strategies should be in place at local, national and international levels to prepare for predictable crises of various sorts, rather than waiting for them to occur and responding belatedly, or relying on personal sacrifices by staff to keep

  15. Pressurized Thermal Shock, Pts

    International Nuclear Information System (INIS)

    Boyd, C.

    2008-01-01

    Pressurized Thermal Shock (Pts) refers to a condition that challenges the integrity of the reactor pressure vessel. The root cause of this problem is the radiation embrittlement of the reactor vessel. This embrittlement leads to an increase in the reference temperature for nil ductility transition (RTNDT). RTNDT can increase to the point where the reactor vessel material can loose fracture toughness during overcooling events. The analysis of the risk of having a Pts for a specific plant is a multi-disciplinary problem involving probabilistic risk analysis (PRA), thermal-hydraulic analysis, and ultimately a structural and fracture analysis of the vessel wall. The PRA effort involves the postulation of overcooling events and ultimately leads to an integrated risk analysis. The thermal-hydraulic effort involves the difficult task of predicting the system behavior during a postulated overcooling scenario with a special emphasis on predicting the thermal and mechanic loadings on the reactor pressure vessel wall. The structural and fracture analysis of the reactor vessel wall relies on the thermal-hydraulic conditions as boundary conditions. The US experience has indicated that medium and large diameter primary system breaks dominate the risk of Pts along with scenarios that involve a stuck open valve (and associated system cooldown) that recloses resulting in system re-pressurization while the vessel wall is cool.

  16. Toxic shock syndrome

    Science.gov (United States)

    Staphylococcal toxic shock syndrome; Toxic shock-like syndrome; TSLS ... Toxic shock syndrome is caused by a toxin produced by some types of staphylococcus bacteria. A similar problem, called toxic shock- ...

  17. Effect of mechanical ventilation on systemic oxygen extraction and lactic acidosis during early septic shock in rats.

    Science.gov (United States)

    Griffel, M I; Astiz, M E; Rackow, E C; Weil, M H

    1990-01-01

    We studied the effect of mechanical ventilation on systemic oxygen extraction and lactic acidosis in peritonitis and shock in rats. Sepsis was induced by cecal ligation and perforation. After tracheostomy, rats were randomized to spontaneous breathing (S) or mechanical ventilation with paralysis (V). Five animals were studied in each group. The V animals were paralyzed with pancuronium bromide to eliminate respiratory effort. Mechanical ventilation consisted of controlled ventilation using a rodent respirator with periodic adjustment of minute ventilation to maintain PaCO2 and pH within normal range. Arterial and central venous blood gases and thermodilution cardiac output were measured at baseline before abdominal surgery, and sequentially at 0.5, 3.5, and 6 h after surgery. At 6 h, cardiac output was 193 +/- 30 ml/kg.min in S animals and 199 +/- 32 ml/kg.min in V animals (NS). The central venous oxygen saturation was 27.4 +/- 4.7% in S animals and 30.0 +/- 6.4% in V animals (NS). Systemic oxygen extraction was 70 +/- 5% in S animals and 67 +/- 6% in V animals (NS). Arterial lactate was 2.4 +/- 0.4 mmol/L in S animals and 2.2 +/- 0.5 mmol/L in V animals (NS). The S animals developed lethal hypotension at 6.6 +/- 0.4 h compared to 6.8 +/- 0.4 h in V animals (NS). These data suggest that mechanical ventilation does not decrease systemic oxygen extraction or ameliorate the development of lactic acidosis during septic shock.

  18. Criteriom of efficiency of thermometric systems with increased reliability

    International Nuclear Information System (INIS)

    Sal'nikov, N.L.; Filimonov, E.V.

    1995-01-01

    Problems on metrological reliability of thermometric systems, intended for temperature regime control at nuclear power facilities are discussed. Thermoelectrical converters and resistance thermoconverters are the most utilized sources of thermometric information at nuclear power plants. Two or more transducers are proposed to be unified in one measurement system in order to increase the accuracy of temperature measurements through obtaining surplus values. Two versions of thermometric systems organization are considered. The first system combined various-type temperature transducers whereas the second system consists of two similar-type transducers. It is established that thermometric systems with various-type transducers are characterized by higher metrological reliability. 3 refs.; 2 figs

  19. Conception and realization of an expert system to help the interpretation of the mechanical shocks in a nuclear power plant

    International Nuclear Information System (INIS)

    Brunet, E.

    1988-01-01

    The computer system MIGRE, developed with the aim of helping the understanding of mechanical shocks in the nuclear power plant primary circuit. The MIGRE system allows the description of a study domain, the acquisition and exploitation of operational knowledges. The structural organization of the system is submitted to two constraints: in the first place, the system's operation depends on the accomplishment and development of an application, and on a diagnostic's research; the second constraint is the fact that the work space of PROLOG, on Macintoch, is restricted. A specific configuration is associated to each one of the work environments. The organization principle (in ''hierarchical Worlds'') of a program by PROLOG, allows to reach easily this kind of architecture. This principle makes a modular organization easy and allows to distinguish statical from dynamical steps of the system. The selection of the system different functions takes place by menus. The transition from one configuration to another is automatically effectuated and unseen by the user. Problems applying the Knowledge acquisition and the wandering bodies function, are also considered [fr

  20. Life Shocks and Homelessness

    Science.gov (United States)

    Corman, Hope; Noonan, Kelly; Reichman, Nancy E.

    2014-01-01

    We exploited an exogenous health shock—namely, the birth of a child with a severe health condition—to investigate the effect of a life shock on homelessness in large cities in the United States as well as the interactive effects of the shock with housing market characteristics. We considered a traditional measure of homelessness, two measures of housing instability thought to be precursors to homelessness, and a combined measure that approximates the broadened conceptualization of homelessness under the 2009 Homeless Emergency Assistance and Rapid Transition to Housing Act (2010). We found that the shock substantially increases the likelihood of family homelessness, particularly in cities with high housing costs. The findings are consistent with the economic theory of homelessness, which posits that homelessness results from a conjunction of adverse circumstances in which housing markets and individual characteristics collide. PMID:23868747

  1. Health Shocks and Retirement:

    DEFF Research Database (Denmark)

    Datta Gupta, Nabanita; Larsen, Mona

    We investigate the effect of an acute health shock on retirement among elderly male workers in Denmark, 1991-1999, and in particular whether various welfare state programs and institutions impinge on the retirement effect. The results show that an acute health event increases the retirement chances...... significant. For the most part, the retirement effect following a health shock seems to be immune to the availability of a multitude of government programs for older workers in Denmark....... benefits in Denmark nor by the promotion of corporate social responsibility initiatives since the mid-1990s. In the late 1990s, however, the retirement rate following a health shock is reduced to 3% with the introduction of the subsidized employment program (fleksjob) but this effect is not strongly...

  2. Molecular origins of anisotropic shock propagation in crystalline and amorphous polyethylene

    Science.gov (United States)

    O'Connor, Thomas C.; Elder, Robert M.; Sliozberg, Yelena R.; Sirk, Timothy W.; Andzelm, Jan W.; Robbins, Mark O.

    2018-03-01

    Molecular dynamics simulations are used to analyze shock propagation in amorphous and crystalline polyethylene. Results for the shock velocity Us are compared to predictions from Pastine's equation of state and hydrostatic theory. The results agree with Pastine at high impact velocities. At low velocities the yield stress becomes important, increasing the shock velocity and leading to anisotropy in the crystalline response. Detailed analysis of changes in atomic order reveals the origin of the anisotropic response. For shock along the polymer backbone, an elastic front is followed by a plastic front where chains buckle with a characteristic wavelength. Shock perpendicular to the chain backbone can produce plastic deformation or transitions to different orthorhombic or monoclinic structures, depending on the impact speed and direction. Tensile loading does not produce stable shocks: Amorphous systems craze and fracture while for crystals the front broadens linearly with time.

  3. No increased systemic fibrinolysis in women with heavy menstrual bleeding

    NARCIS (Netherlands)

    Wiewel-Verschueren, S.; Knol, H. M.; Lisman, T.; Bogchelman, D. H.; Kluin-Nelemans, J. C.; van der Zee, A.G.J.; Mulder, A.B.; Meijer, K.

    BackgroundBleeding disorders have been recognized as important etiologic or contributory factors in women with heavy menstrual bleeding. Fibrinolysis in the endometrium plays a role in heavy menstrual bleeding. It is unknown whether increased systemic fibrinolysis might also increase the risk of

  4. Techniques for increasing the reliability of accelerator control system electronics

    International Nuclear Information System (INIS)

    Utterback, J.

    1993-09-01

    As the physical size of modern accelerators becomes larger and larger, the number of required control system circuit boards increases, and the probability of one of those circuit boards failing while in service also increases. In order to do physics, the experimenters need the accelerator to provide beam reliably with as little down time as possible. With the advent of colliding beams physics, reliability becomes even more important due to the fact that a control system failure can cause the loss of painstakingly produced antiprotons. These facts prove the importance of keeping reliability in mind when designing and maintaining accelerator control system electronics

  5. Microgravity Experiment: The Fate of Confined Shock Waves

    Science.gov (United States)

    Kobel, P.; Obreschkow, D.; Dorsaz, N.; de Bosset, A.; Farhat, M.

    2007-11-01

    Shockwave induced cavitation is a form of hydrodynamic cavitation generated by the interaction of shock waves with vapor nuclei and microscopic impurities. Both the shock waves and the induced cavitation are known as sources of erosion damage in hydraulic industrial systems and hence represent an important research topic in fluid dynamics. Here we present the first investigation of shock wave induced cavitation inside closed and isolated liquid volumes, which confine the shock wave by reflections and thereby promise a particularly strong coupling with cavitation. A microgravity platform (ESA, 42^nd parabolic flight campaign) was used to produce stable water drops with centimetric diameters. Inside these drops, a fast electrical discharge was generated to release a strong shock wave. This setting results in an amplified form of shockwave induced cavitation, visible in high-speed images as a transient haze of sub-millimetric bubbles synchronized with the shockwave radiation. A comparison between high-speed visualizations and 3D simulations of a shock front inside a liquid sphere reveals that focus zones within the drop lead to a significantly increased density of induced cavitation. Considering shock wave crossing and focusing may hence prove crucially useful to understand the important process of cavitation erosion.

  6. Ultrafast growth of wadsleyite in shock-produced melts and its implications for early solar system impact processes

    Energy Technology Data Exchange (ETDEWEB)

    Tschauner, Oliver; Asimow, Paul; Kostandova, Natalia; Ahrens, Thomas; Ma, Chi; Sinogeikin, Stanislav; Liu, Zhenxian; Fakra, Sirine; Tamura, Nobumichi

    2009-12-01

    We observed micrometer-sized grains of wadsleyite, a high-pressure phase of (Mg,Fe)2SiO4, in the recovery products of a shock experiment. We infer these grains crystallized from shock-generated melt over a time interval of <1 fs, the maximum time over which our experiment reached and sustained pressure sufficient to stabilize this phase. This rapid crystal growth rate (=1 m/s) suggests that, contrary to the conclusions of previous studies of the occurrence of high-pressure phases in shock-melt veins in strongly shocked meteorites, the growth of high-pressure phases from the melt during shock events is not diffusion-controlled. Another process, such as microturbulent transport, must be active in the crystal growth process. This result implies that the times necessary to crystallize the high-pressure phases in shocked meteorites may correspond to shock pressure durations achieved on impacts between objects 1-5 m in diameter and not, as previously inferred, =1-5 km in diameter. These results may also provide another pathway for syntheses, via shock recovery, of some high-value, high-pressure phases.

  7. Shock Waves

    CERN Document Server

    Jiang, Z

    2005-01-01

    The International Symposium on Shock Waves (ISSW) is a well established series of conferences held every two years in a different location. A unique feature of the ISSW is the emphasis on bridging the gap between physicists and engineers working in fields as different as gas dynamics, fluid mechanics and materials sciences. The main results presented at these meetings constitute valuable proceedings that offer anyone working in this field an authoritative and comprehensive source of reference.

  8. Simulations of Converging Shock Collisions for Shock Ignition

    Science.gov (United States)

    Sauppe, Joshua; Dodd, Evan; Loomis, Eric

    2016-10-01

    Shock ignition (SI) has been proposed as an alternative to achieving high gain in inertial confinement fusion (ICF) targets. A central hot spot below the ignition threshold is created by an initial compression pulse, and a second laser pulse drives a strong converging shock into the fuel. The collision between the rebounding shock from the compression pulse and the converging shock results in amplification of the converging shock and increases the hot spot pressure above the ignition threshold. We investigate shock collision in SI drive schemes for cylindrical targets with a polystyrene foam interior using radiation-hydrodynamics simulations with the RAGE code. The configuration is similar to previous targets fielded on the Omega laser. The CH interior results in a lower convergence ratio and the cylindrical geometry facilitates visualization of the shock transit using an axial X-ray backlighter, both of which are important for comparison to potential experimental measurements. One-dimensional simulations are used to determine shock timing, and the effects of low mode asymmetries in 2D computations are also quantified. LA-UR-16-24773.

  9. Self-gravito-acoustic shock structures in a self-gravitating, strongly coupled, multi-component, degenerate quantum plasma system

    Science.gov (United States)

    Mamun, A. A.

    2017-10-01

    The existence of self-gravito-acoustic (SGA) shock structures (SSs) associated with negative self-gravitational potential in a self-gravitating, strongly coupled, multi-component, degenerate quantum plasma (SGSCMCDQP) system is predicted for the first time. The modified Burgers (MB) equation, which is valid for both planar and non-planar (spherical) geometries, is derived analytically, and solved numerically. It is shown that the longitudinal viscous force acting on inertial plasma species of the plasma system is the source of dissipation and is responsible for the formation of these SGA SSs in the plasma system. The time evolution of these SGA SSs is also shown for different values (viz., 0.5, 1, and 2) of Γ, where Γ is the ratio of the nonlinear coefficient to the dissipative coefficient in the MB equation. The SGSCMCDQP model and the numerical analysis of the MB equation presented here are so general that they can be applied in any type of SGSCMCDQP systems like astrophysical compact objects having planar or non-planar (spherical) shape.

  10. Shocking matter to extreme conditions

    International Nuclear Information System (INIS)

    Gupta, Y.M.; Sharma, S.M.

    1997-01-01

    A good understanding of the thermodynamic response of matter at high compression and high energy densities is important to several areas of physics. Shock-wave experiments are uniquely suited for obtaining data at extreme conditions, and a shock-compressed matter can be viewed as a condensed system with or without dissociation or as a strongly coupled plasma. This article reviews work by Da Silva et al. in which irradiances ranging from 5x10 superscript 12 to 2x10 superscript 14 W/cm 2 were used to generate 8- to 10-ns square pulses in liquid deuterium. The authors demonstrated negligible pre-heating of the sample, steady propagation of the shock wave, and direct determination of the shock wave velocity along with particle velocity and density in the shocked state. Da Silva et al. results are compared with models and other experimental information, and the usefulness of the data in other areas is assessed. 11 refs., 1 fig

  11. Oscillating nonlinear acoustic shock waves

    DEFF Research Database (Denmark)

    Gaididei, Yuri; Rasmussen, Anders Rønne; Christiansen, Peter Leth

    2016-01-01

    We investigate oscillating shock waves in a tube using a higher order weakly nonlinear acoustic model. The model includes thermoviscous effects and is non isentropic. The oscillating shock waves are generated at one end of the tube by a sinusoidal driver. Numerical simulations show that at resona......We investigate oscillating shock waves in a tube using a higher order weakly nonlinear acoustic model. The model includes thermoviscous effects and is non isentropic. The oscillating shock waves are generated at one end of the tube by a sinusoidal driver. Numerical simulations show...... polynomial in the space and time variables, we find analytical approximations to the observed single shock waves in an infinitely long tube. Using perturbation theory for the driven acoustic system approximative analytical solutions for the off resonant case are determined....

  12. "Driverless" Shocks in the Interplanetary Medium

    Science.gov (United States)

    Gopalswamy, N.; Kaiser, M. L.; Lara, A.

    1999-01-01

    Many interplanetary shocks have been detected without an obvious driver behind them. These shocks have been thought to be either blast waves from solar flares or shocks due to sudden increase in solar wind speed caused by interactions between large scale open and closed field lines of the Sun. We investigated this problem using a set of interplanetary shock detected {\\it in situ} by the Wind space craft and tracing their solar origins using low frequency radio data obtained by the Wind/WAVES experiment. For each of these "driverless shocks" we could find a unique coronal mass ejections (CME) event observed by the SOHO (Solar and Heliospheric Observatory) coronagraphs. We also found that these CMEs were ejected at large angles from the Sun-Earth line. It appears that the "driverless shocks" are actually driver shocks, but the drivers were not intercepted by the spacecraft. We conclude that the interplanetary shocks are much more extended than the driving CMEs.

  13. Electron transport and shock ignition

    Energy Technology Data Exchange (ETDEWEB)

    Bell, A R; Tzoufras, M, E-mail: t.bell1@physics.ox.ac.uk [Clarendon Laboratory, University of Oxford, Parks Road, Oxford OX1 3PU (United Kingdom)

    2011-04-15

    Inertial fusion energy (IFE) offers one possible route to commercial energy generation. In the proposed 'shock ignition' route to fusion, the target is compressed at a relatively low temperature and then ignited using high intensity laser irradiation which drives a strong converging shock into the centre of the fuel. With a series of idealized calculations we analyse the electron transport of energy into the target, which produces the pressure responsible for driving the shock. We show that transport in shock ignition lies near the boundary between ablative and heat front regimes. Moreover, simulations indicate that non-local effects are significant in the heat front regime and might lead to increased efficiency by driving the shock more effectively and reducing heat losses to the plasma corona.

  14. Diaphragmless shock wave generators for industrial applications of shock waves

    Science.gov (United States)

    Hariharan, M. S.; Janardhanraj, S.; Saravanan, S.; Jagadeesh, G.

    2011-06-01

    The prime focus of this study is to design a 50 mm internal diameter diaphragmless shock tube that can be used in an industrial facility for repeated loading of shock waves. The instantaneous rise in pressure and temperature of a medium can be used in a variety of industrial applications. We designed, fabricated and tested three different shock wave generators of which one system employs a highly elastic rubber membrane and the other systems use a fast acting pneumatic valve instead of conventional metal diaphragms. The valve opening speed is obtained with the help of a high speed camera. For shock generation systems with a pneumatic cylinder, it ranges from 0.325 to 1.15 m/s while it is around 8.3 m/s for the rubber membrane. Experiments are conducted using the three diaphragmless systems and the results obtained are analyzed carefully to obtain a relation between the opening speed of the valve and the amount of gas that is actually utilized in the generation of the shock wave for each system. The rubber membrane is not suitable for industrial applications because it needs to be replaced regularly and cannot withstand high driver pressures. The maximum shock Mach number obtained using the new diaphragmless system that uses the pneumatic valve is 2.125 ± 0.2%. This system shows much promise for automation in an industrial environment.

  15. Selected Methods For Increases Reliability The Of Electronic Systems Security

    Directory of Open Access Journals (Sweden)

    Paś Jacek

    2015-11-01

    Full Text Available The article presents the issues related to the different methods to increase the reliability of electronic security systems (ESS for example, a fire alarm system (SSP. Reliability of the SSP in the descriptive sense is a property preservation capacity to implement the preset function (e.g. protection: fire airport, the port, logistics base, etc., at a certain time and under certain conditions, e.g. Environmental, despite the possible non-compliance by a specific subset of elements this system. Analyzing the available literature on the ESS-SSP is not available studies on methods to increase the reliability (several works similar topics but moving with respect to the burglary and robbery (Intrusion. Based on the analysis of the set of all paths in the system suitability of the SSP for the scenario mentioned elements fire events (device critical because of security.

  16. Teleconnected food supply shocks

    Science.gov (United States)

    Bren d'Amour, Christopher; Wenz, Leonie; Kalkuhl, Matthias; Steckel, Jan Christoph; Creutzig, Felix

    2016-03-01

    The 2008-2010 food crisis might have been a harbinger of fundamental climate-induced food crises with geopolitical implications. Heat-wave-induced yield losses in Russia and resulting export restrictions led to increases in market prices for wheat across the Middle East, likely contributing to the Arab Spring. With ongoing climate change, temperatures and temperature variability will rise, leading to higher uncertainty in yields for major nutritional crops. Here we investigate which countries are most vulnerable to teleconnected supply-shocks, i.e. where diets strongly rely on the import of wheat, maize, or rice, and where a large share of the population is living in poverty. We find that the Middle East is most sensitive to teleconnected supply shocks in wheat, Central America to supply shocks in maize, and Western Africa to supply shocks in rice. Weighing with poverty levels, Sub-Saharan Africa is most affected. Altogether, a simultaneous 10% reduction in exports of wheat, rice, and maize would reduce caloric intake of 55 million people living in poverty by about 5%. Export bans in major producing regions would put up to 200 million people below the poverty line at risk, 90% of which live in Sub-Saharan Africa. Our results suggest that a region-specific combination of national increases in agricultural productivity and diversification of trade partners and diets can effectively decrease future food security risks.

  17. Shock waves in gas and plasma

    International Nuclear Information System (INIS)

    Niu, K.

    1996-01-01

    A shock wave is a discontinuous surface that connects supersonic flow with subsonic flow. After a shock wave, flow velocity is reduced, and pressure and temperature increase; entropy especially increases across a shock wave. Therefore, flow is in nonequilibrium, and irreversible processes occur inside the shock layer. The thickness of a shock wave in neutral gas is of the order of the mean free path of the fluid particle. A shock wave also appears in magnetized plasma. Provided that when the plasma flow is parallel to the magnetic field, a shock wave appears if the governing equation for velocity potential is in hyperbolic type in relation with the Mach number and the Alfven number. When the flow is perpendicular to the magnetic field, the Maxwell stress, in addition to the pressure, plays a role in the shock wave in plasma. When the plasma temperature is so high, as the plasma becomes collision-free, another type of shock wave appears. In a collision-free shock wave, gyromotions of electrons around the magnetic field lines cause the shock formation instead of collisions in a collision-dominant plasma or neutral gas. Regardless of a collision-dominant or collision-free shock wave, the fluid that passes through the shock wave is heated in addition to being compressed. In inertial confinement fusion, the fuel must be compressed. Really, implosion motion performs fuel compression. A shock wave, appearing in the process of implosion, compresses the fuel. The shock wave, however, heats the fuel more intensively, and it makes it difficult to compress the fuel further because high temperatures invite high pressure. Adiabatic compression of the fuel is the desired result during the implosion, without the formation of a shock wave. (Author)

  18. SALICYLATE INCREASES THE GAIN OF THE CENTRAL AUDITORY SYSTEM

    Science.gov (United States)

    Sun, W.; Lu, J.; Stolzberg, D.; Gray, L.; Deng, A.; Lobarinas, E.; Salvi, R. J.

    2009-01-01

    High doses of salicylate, the anti-inflammatory component of aspirin, induce transient tinnitus and hearing loss. Systemic injection of 250 mg/kg of salicylate, a dose that reliably induces tinnitus in rats, significantly reduced the sound evoked output of the rat cochlea. Paradoxically, salicylate significantly increased the amplitude of the sound-evoked field potential from the auditory cortex (AC) of conscious rats, but not the inferior colliculus (IC). When rats were anesthetized with isoflurane, which increases GABA-mediated inhibition, the salicylate-induced AC amplitude enhancement was abolished, whereas ketamine, which blocks N-methyl-d-aspartate receptors, further increased the salicylate-induced AC amplitude enhancement. Direct application of salicylate to the cochlea, however, reduced the response amplitude of the cochlea, IC and AC, suggesting the AC amplitude enhancement induced by systemic injection of salicylate does not originate from the cochlea. To identify a behavioral correlate of the salicylate-induced AC enhancement, the acoustic startle response was measured before and after salicylate treatment. Salicylate significantly increased the amplitude of the startle response. Collectively, these results suggest that high doses of salicylate increase the gain of the central auditory system, presumably by down-regulating GABA-mediated inhibition, leading to an exaggerated acoustic startle response. The enhanced startle response may be the behavioral correlate of hyperacusis that often accompanies tinnitus and hearing loss. Published by Elsevier Ltd on behalf of IBRO. PMID:19154777

  19. The cosmic-ray shock structure problem for relativistic shocks

    Science.gov (United States)

    Webb, G. M.

    1985-01-01

    The time asymptotic behaviour of a relativistic (parallel) shock wave significantly modified by the diffusive acceleration of cosmic-rays is investigated by means of relativistic hydrodynamical equations for both the cosmic-rays and thermal gas. The form of the shock structure equation and the dispersion relation for both long and short wavelength waves in the system are obtained. The dependence of the shock acceleration efficiency on the upstream fluid spped, long wavelength Mach number and the ratio N = P sub co/cP sub co+P sub go)(Psub co and P sub go are the upstream cosmic-ray and thermal gas pressures respectively) are studied.

  20. Quantifying the increasing sensitivity of power systems to climate variability

    Science.gov (United States)

    Bloomfield, H. C.; Brayshaw, D. J.; Shaffrey, L. C.; Coker, P. J.; Thornton, H. E.

    2016-12-01

    Large quantities of weather-dependent renewable energy generation are expected in power systems under climate change mitigation policies, yet little attention has been given to the impact of long term climate variability. By combining state-of-the-art multi-decadal meteorological records with a parsimonious representation of a power system, this study characterises the impact of year-to-year climate variability on multiple aspects of the power system of Great Britain (including coal, gas and nuclear generation), demonstrating why multi-decadal approaches are necessary. All aspects of the example system are impacted by inter-annual climate variability, with the impacts being most pronounced for baseload generation. The impacts of inter-annual climate variability increase in a 2025 wind-power scenario, with a 4-fold increase in the inter-annual range of operating hours for baseload such as nuclear. The impacts on peak load and peaking-plant are comparably small. Less than 10 years of power supply and demand data are shown to be insufficient for providing robust power system planning guidance. This suggests renewable integration studies—widely used in policy, investment and system design—should adopt a more robust approach to climate characterisation.

  1. Myosin light chain kinase is necessary for post-shock mesenteric lymph drainage enhancement of vascular reactivity and calcium sensitivity in hemorrhagic-shocked rats

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Y.P.; Niu, C.Y.; Zhao, Z.G.; Zhang, L.M.; Si, Y.H. [Institute of Microcirculation, Hebei North University, Hebei (China)

    2013-08-10

    Vascular hyporeactivity is an important factor in irreversible shock, and post-shock mesenteric lymph (PSML) blockade improves vascular reactivity after hemorrhagic shock. This study explored the possible involvement of myosin light chain kinase (MLCK) in PSML-mediated vascular hyporeactivity and calcium desensitization. Rats were divided into sham (n=12), shock (n=18), and shock+drainage (n=18) groups. A hemorrhagic shock model (40±2 mmHg, 3 h) was established in the shock and shock+drainage groups. PSML drainage was performed from 1 to 3 h from start of hypotension in shock+drainage rats. Levels of phospho-MLCK (p-MLCK) were determined in superior mesenteric artery (SMA) tissue, and the vascular reactivity to norepinephrine (NE) and sensitivity to Ca{sup 2+} were observed in SMA rings in an isolated organ perfusion system. p-MLCK was significantly decreased in the shock group compared with the sham group, but increased in the shock+drainage group compared with the shock group. Substance P (1 nM), an agonist of MLCK, significantly elevated the decreased contractile response of SMA rings to both NE and Ca{sup 2+} at various concentrations. Maximum contractility (E{sub max}) in the shock group increased with NE (from 0.179±0.038 to 0.440±0.177 g/mg, P<0.05) and Ca{sup 2+} (from 0.515±0.043 to 0.646±0.096 g/mg, P<0.05). ML-7 (0.1 nM), an inhibitor of MLCK, reduced the increased vascular response to NE and Ca{sup 2+} at various concentrations in the shock+drainage group (from 0.744±0.187 to 0.570±0.143 g/mg in E{sub max} for NE and from 0.729±0.037 to 0.645±0.056 g/mg in E{sub max} for Ca{sup 2+}, P<0.05). We conclude that MLCK is an important contributor to PSML drainage, enhancing vascular reactivity and calcium sensitivity in rats with hemorrhagic shock.

  2. Shock Wave Dynamics in Weakly Ionized Plasmas

    Science.gov (United States)

    Johnson, Joseph A., III

    1999-01-01

    An investigation of the dynamics of shock waves in weakly ionized argon plasmas has been performed using a pressure ruptured shock tube. The velocity of the shock is observed to increase when the shock traverses the plasma. The observed increases cannot be accounted for by thermal effects alone. Possible mechanisms that could explain the anomalous behavior include a vibrational/translational relaxation in the nonequilibrium plasma, electron diffusion across the shock front resulting from high electron mobility, and the propagation of ion-acoustic waves generated at the shock front. Using a turbulence model based on reduced kinetic theory, analysis of the observed results suggest a role for turbulence in anomalous shock dynamics in weakly ionized media and plasma-induced hypersonic drag reduction.

  3. System-wide emissions implications of increased wind power penetration.

    Science.gov (United States)

    Valentino, Lauren; Valenzuela, Viviana; Botterud, Audun; Zhou, Zhi; Conzelmann, Guenter

    2012-04-03

    This paper discusses the environmental effects of incorporating wind energy into the electric power system. We present a detailed emissions analysis based on comprehensive modeling of power system operations with unit commitment and economic dispatch for different wind penetration levels. First, by minimizing cost, the unit commitment model decides which thermal power plants will be utilized based on a wind power forecast, and then, the economic dispatch model dictates the level of production for each unit as a function of the realized wind power generation. Finally, knowing the power production from each power plant, the emissions are calculated. The emissions model incorporates the effects of both cycling and start-ups of thermal power plants in analyzing emissions from an electric power system with increasing levels of wind power. Our results for the power system in the state of Illinois show significant emissions effects from increased cycling and particularly start-ups of thermal power plants. However, we conclude that as the wind power penetration increases, pollutant emissions decrease overall due to the replacement of fossil fuels.

  4. Simulation of mechanical shock environments

    International Nuclear Information System (INIS)

    Lalanne, Christian.

    1975-07-01

    Shocks can produce a severe mechanical environment which must be taken into account when designing and developing new equipments. After some mathematical (Laplace and Fourier transforms) and mechanical recalls (response of a one degree freedom system to a sinusoidal excitation), different analysis methods are compared, these methods being the most used now to compare relative severities of tests and establish specifications. A few chapter deal with the different properties of simple, easy to produce, shock shapes. Then some now-in-use programmators or shock-machines specifications are shown. A final chapter concerns acceleration transducers [fr

  5. Measurement and Analysis of the Extreme Physical Shock Environment Experienced by Crane-Mounted Radiation Detection Systems.

    Energy Technology Data Exchange (ETDEWEB)

    Boyd, M [Texas A & M Univ., College Station, TX (United States); Erchinger, J [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Marianno, C [Texas A & M Univ., College Station, TX (United States); Kallenbach, Gene A. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Grypp, M [US Dept. of the Navy

    2017-09-01

    Potentially, radiation detectors at ports of entry could be mounted on container gantry crane spreaders to monitor cargo containers entering and leaving the country. These detectors would have to withstand the extreme physical environment experienced by these spreaders during normal operations. Physical shock data from the gable ends of a spreader were recorded during the loading and unloading of a cargo ship with two Lansmont SAVER 9X30 units (with padding) and two PCB Piezotronics model 340A50 accelerometers (hard mounted). Physical shocks in the form of rapid acceleration were observed in all accelerometer units with values ranging from 0.20 g’s to 199.99 g’s. The majority of the shocks for all the Lansmont and PCB accelerometers were below 50 g’s. The Lansmont recorded mean shocks of 21.83 ± 13.62 g’s and 24.78 ± 11.49 g’s while the PCB accelerometers experienced mean shocks of 34.39 ± 25.51 g’s and 41.77 ± 22.68 g’s for the landside and waterside units, respectively. Encased detector units with external padding should be designed to withstand at least 200 g’s of acceleration without padding and typical shocks of 30 g’s with padding for mounting on a spreader.

  6. 5,7-Dimethoxycoumarin prevents chronic mild stress induced depression in rats through increase in the expression of heat shock protein-70 and inhibition of monoamine oxidase-A levels

    Directory of Open Access Journals (Sweden)

    Wei Yang

    2018-02-01

    Full Text Available The current study was aimed to investigate the role of 5,7-dimethoxycoumarin in the prevention of chronic mild stress induced depression in rats. The chronic mild stress rat model was prepared using the known protocols. The results from open-field test showed that rats in the chronic mild stress group scored very low in terms of crossings and rearings than those of the normal rats. However, pre-treatment of the rats with 10 mg/kg doses of 5,7-dimethoxycoumarin prevented decline in the locomotor activity by chronic mild stress. The level of monoamine oxidase-A in the chronic mild stress rat hippocampus was markedly higher. Chronic mild stress induced increase in the monoamine oxidase-A level was inhibited by pre-treatment with 10 mg/kg doses of 5,7-dimethoxycoumarin in the rats. Chronic mild stress caused a marked increase in the level of caspase-3 mRNA and proteins in rat hippocampus tissues. The increased level of caspase-3 mRNA and protein level was inhibited by treatment of rats with 5,7-dimethoxycoumarin (10 mg/kg. 5,7-Dimethoxycoumarin administration into the rats caused a marked increase in the levels of heat shock protein-70 mRNA and protein. The levels of heat shock protein-70 were markedly lower both in normal and chronic mild stress groups of rats compared to the 5,7-dimethoxycoumarin treated groups. Thus 5,7-dimethoxycoumarin prevented the chronic mild stress induced depression in rats through an increase in the expression of heat shock protein-70 and inhibition of monoamine oxidase-A levels.

  7. 5,7-Dimethoxycoumarin prevents chronic mild stress induced depression in rats through increase in the expression of heat shock protein-70 and inhibition of monoamine oxidase-A levels.

    Science.gov (United States)

    Yang, Wei; Wang, Huanlin

    2018-02-01

    The current study was aimed to investigate the role of 5,7-dimethoxycoumarin in the prevention of chronic mild stress induced depression in rats. The chronic mild stress rat model was prepared using the known protocols. The results from open-field test showed that rats in the chronic mild stress group scored very low in terms of crossings and rearings than those of the normal rats. However, pre-treatment of the rats with 10 mg/kg doses of 5,7-dimethoxycoumarin prevented decline in the locomotor activity by chronic mild stress. The level of monoamine oxidase-A in the chronic mild stress rat hippocampus was markedly higher. Chronic mild stress induced increase in the monoamine oxidase-A level was inhibited by pre-treatment with 10 mg/kg doses of 5,7-dimethoxycoumarin in the rats. Chronic mild stress caused a marked increase in the level of caspase-3 mRNA and proteins in rat hippocampus tissues. The increased level of caspase-3 mRNA and protein level was inhibited by treatment of rats with 5,7-dimethoxycoumarin (10 mg/kg). 5,7-Dimethoxycoumarin administration into the rats caused a marked increase in the levels of heat shock protein-70 mRNA and protein. The levels of heat shock protein-70 were markedly lower both in normal and chronic mild stress groups of rats compared to the 5,7-dimethoxycoumarin treated groups. Thus 5,7-dimethoxycoumarin prevented the chronic mild stress induced depression in rats through an increase in the expression of heat shock protein-70 and inhibition of monoamine oxidase-A levels.

  8. Ray equations of a weak shock in a hyperbolic system of ...

    Indian Academy of Sciences (India)

    differential form of this system of conservation laws is a hyperbolic system of partial differential equations. A(u)ut + B(α)(u)uxα = 0,. (1.3) where. A(u) = 〈∇u,H〉 and B(α)(u) = 〈∇u, F(α)〉,. (1.4) and we use the summation convention that a repeated symbol in subscripts and super- scripts in a term will mean summation over the ...

  9. Shock stability in systems that change type. Final grant report to the Department of Energy

    International Nuclear Information System (INIS)

    Keyfitz, B.L.

    1995-01-01

    The aim of the original project was to investigate systems of conservation laws that change type. Progress was made on this problem. During the last period of the grant, the author began an investigation of a multidimensional system related to Mach reflection which goes beyond the original work proposed. This has been fruitful direction in which to apply expertise on change of type. Some basic theoretical results have been found

  10. Increasing draft capability for retrofit flue gas desulfurization systems

    International Nuclear Information System (INIS)

    Petersen, R.D.; Basel, B.E.; Mosier, R.J.

    1992-01-01

    The retrofit installation of flue gas desulfurization (FGD) systems results in significantly higher draft losses for existing generating stations. Consequently, the means for increasing draft capability must be included in many FGD retrofit projects. Consideration is given to several alternatives for increasing draft capability. Alternatives are developed for new induced draft (ID) fans to replace the existing ID fans and for new booster fans to supplement the existing ID fans. Both centrifugal and axial fans are evaluated, as are different means of fan volume control. Each alternative is evaluated on the basis of technical merit and economics. Presented are the development of fan alternatives and results of the technical and economic evaluations

  11. Planar and non-planar nucleus-acoustic shock structures in self-gravitating degenerate quantum plasma systems

    Science.gov (United States)

    Zaman, D. M. S.; Amina, M.; Dip, P. R.; Mamun, A. A.

    2017-11-01

    The basic properties of planar and non-planar (spherical and cylindrical) nucleus-acoustic (NA) shock structures (SSs) in a strongly coupled self-gravitating degenerate quantum plasma system (containing strongly coupled non-relativistically degenerate heavy nuclear species, weakly coupled non-relativistically degenerate light nuclear species, and inertialess non-/ultra-relativistically degenerate electrons) have been investigated. The generalized quantum hydrodynamic model and the reductive perturbation method have been used to derive the modified Burgers equation. It is shown that the strong correlation among heavy nuclear species acts as the source of dissipation and is responsible for the formation of the NA SSs with positive (negative) electrostatic (self-gravitational) potential. It is also observed that the effects of non-/ultra-relativistically degenerate electron pressure, dynamics of non-relativistically degenerate light nuclear species, spherical geometry, etc., significantly modify the basic features of the NA SSs. The applications of our results in astrophysical compact objects like white dwarfs and neutron stars are briefly discussed.

  12. Theory and Experiment on Radiative Shocks

    Science.gov (United States)

    Drake, R. Paul

    2005-07-01

    The current generation of high-energy-density research facilities has enabled the beginnings of experimental studies of radiation hydrodynamic systems, common in astrophysics but difficult to produce in the laboratory. Radiative shock experiments specifically have been a topic of increasing effort in recent years. Our group and collaborators [1] have emphasized the radiographic observation of structure in radiative shocks. These shocks have been produced on the Omega laser by driving a Be piston through Xenon at velocities above 100 km/s. The talk will summarize these experiments and their results. Interpreting these and other experiments is hampered by the limited range of assumptions used in published theories, and by the limitations in readily available simulation tools. This has motivated an examination of radiative shock theory [2]. The talk will summarize the key issues and present results for specific cases. [ 1 ] Gail Glendinning, Ted Perry, Bruce Remington, Jim Knauer, Tom Boehly, and other members of the NLUF Experimental Astrophysics Team. Publications: Reighard et al., Phys. Rev. Lett. submitted; Leibrandt, et al., Ap J., in press, Reighard et al., IFSA 03 Proceedings, Amer. Nucl. Soc. (2004). [2] Useful discussions with Dmitri Ryutov and Serge Bouquet. Supported by the NNSA programs via DOE Grants DE-FG52-03NA00064 and DE FG53 2005 NA26014

  13. Full-field initialized decadal predictions with the MPI earth system model: an initial shock in the North Atlantic

    Science.gov (United States)

    Kröger, Jürgen; Pohlmann, Holger; Sienz, Frank; Marotzke, Jochem; Baehr, Johanna; Köhl, Armin; Modali, Kameswarrao; Polkova, Iuliia; Stammer, Detlef; Vamborg, Freja S. E.; Müller, Wolfgang A.

    2017-12-01

    Our decadal climate prediction system, which is based on the Max-Planck-Institute Earth System Model, is initialized from a coupled assimilation run that utilizes nudging to selected state parameters from reanalyses. We apply full-field nudging in the atmosphere and either full-field or anomaly nudging in the ocean. Full fields from two different ocean reanalyses are considered. This comparison of initialization strategies focuses on the North Atlantic Subpolar Gyre (SPG) region, where the transition from anomaly to full-field nudging reveals large differences in prediction skill for sea surface temperature and ocean heat content (OHC). We show that nudging of temperature and salinity in the ocean modifies OHC and also induces changes in mass and heat transports associated with the ocean flow. In the SPG region, the assimilated OHC signal resembles well OHC from observations, regardless of using full fields or anomalies. The resulting ocean transport, on the other hand, reveals considerable differences between full-field and anomaly nudging. In all assimilation runs, ocean heat transport together with net heat exchange at the surface does not correspond to OHC tendencies, the SPG heat budget is not closed. Discrepancies in the budget in the cases of full-field nudging exceed those in the case of anomaly nudging by a factor of 2-3. The nudging-induced changes in ocean transport continue to be present in the free running hindcasts for up to 5 years, a clear expression of memory in our coupled system. In hindcast mode, on annual to inter-annual scales, ocean heat transport is the dominant driver of SPG OHC. Thus, we ascribe a significant reduction in OHC prediction skill when using full-field instead of anomaly initialization to an initialization shock resulting from the poor initialization of the ocean flow.

  14. Systemic Mastocytosis: A Rare Case of Increased Liver Stiffness

    Directory of Open Access Journals (Sweden)

    Stefanie Adolf

    2012-01-01

    Full Text Available Assessment of liver stiffness (LS by transient elastography (Fibroscan has significantly improved the noninvasive diagnosis of liver fibrosis. We here report on a 55-year-old patient with drastically increased LS due to previously unknown systemic mastocytosis. The patient initially presented with increased weight loss, nocturnal pruritus, increased transaminases, bilirubinemia, and thrombocytopenia. Abdominal ultrasound showed ascites, hepatomegaly, and splenomegaly. In addition, LS was 75 kPa (IQR 0 kPa clearly exceeding the cut-off value for F4 cirrhosis of 12.5 kPa. However, histological analysis of the liver specimen indicated liver involvement by systemic mastocytosis and excluded liver cirrhosis. An additional CT scan detected disseminated bone lesions. After three months of treatment with Midostaurin, LS slightly decreased down to 31.9 kPa (IQR 8.3 kPa. This case illustrates that diffused sinusoidal neoplastic infiltrates are a pitfall in the non-invasive diagnosis of liver cirrhosis. In conclusion, refined clinical algorithms for increased LS should also include mastocytosis in addition to inflammation, congestion, and biliary obstruction.

  15. Effects of response-shock interval and shock intensity on free-operant avoidance responding in the pigeon1

    Science.gov (United States)

    Klein, Marty; Rilling, Mark

    1972-01-01

    Two experiments investigated free-operant avoidance responding with pigeons using a treadle-pressing response. In Experiment I, pigeons were initially trained on a free-operant avoidance schedule with a response-shock interval of 32 sec and a shock-shock interval of 10 sec, and were subsequently exposed to 10 values of the response-shock parameter ranging from 2.5 to 150 sec. The functions relating response rate to response-shock interval were similar to the ones reported by Sidman in his 1953 studies employing rats, and were independent of the order of presentation of the response-shock values. Shock rates decreased as response-shock duration increased. In Experiment II, a free-operant avoidance schedule with a response-shock interval of 20 sec and a shock-shock interval of 5 sec was used, and shock intensities were varied over five values ranging from 2 to 32 mA. Response rates increased markedly as shock intensity increased from 2 to 8 mA, but rates changed little with further increases in shock intensity. Shock rates decreased as intensity increased from 2 to 8 mA, and showed little change as intensity increased from 8 to 32 mA. PMID:4652617

  16. Use of CAE-Systems at Evaluation of Shock Absorbers for Metallurgical Equipment

    Directory of Open Access Journals (Sweden)

    Artiukh Viktor

    2016-01-01

    Full Text Available Work presents results of strength calculations of absorber elastic element that were done by CAE-system and standard method of calculating. It is shown, that use of FEM software allows studying thoroughly the distribution of appropriate stresses on surfaces of elastic element.

  17. Study of the Nonlinear Dropping Shock Response of Expanded Foam Packaging System

    Directory of Open Access Journals (Sweden)

    Huan-xin Jiang

    2013-01-01

    Full Text Available The variational iteration method-2 (VIM-2 is applied to obtain approximate analytical solutions of EPS foam cushioning packaging system. The first-order frequency solution of the equation of motion was obtained and compared with the numerical simulation solution solved by the Runge-Kutta algorithm. The results showed the high accuracy of this VIM with convenient calculation.

  18. Sepsis and septic shock

    Science.gov (United States)

    Hotchkiss, Richard S.; Moldawer, Lyle L.; Opal, Steven M.; Reinhart, Konrad; Turnbull, Isaiah R.; Vincent, Jean-Louis

    2017-01-01

    For more than two decades, sepsis was defined as a microbial infection that produces fever (or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now increasingly being considered a dysregulated systemic inflammatory and immune response to microbial invasion that produces organ injury for which mortality rates are declining to 15–25%. Septic shock remains defined as sepsis with hyperlactataemia and concurrent hypotension requiring vasopressor therapy, with in-hospital mortality rates approaching 30–50%. With earlier recognition and more compliance to best practices, sepsis has become less of an immediate life-threatening disorder and more of a long-term chronic critical illness, often associated with prolonged inflammation, immune suppression, organ injury and lean tissue wasting. Furthermore, patients who survive sepsis have continuing risk of mortality after discharge, as well as long-term cognitive and functional deficits. Earlier recognition and improved implementation of best practices have reduced in-hospital mortality, but results from the use of immunomodulatory agents to date have been disappointing. Similarly, no biomarker can definitely diagnose sepsis or predict its clinical outcome. Because of its complexity, improvements in sepsis outcomes are likely to continue to be slow and incremental. PMID:28117397

  19. Comparison of acoustic shock waves generated by micro and nanosecond lasers for a smart laser surgery system

    Science.gov (United States)

    Nguendon Kenhagho, Hervé K.; Rauter, Georg; Guzman, Raphael; C. Cattin, Philippe; Zam, Azhar

    2018-02-01

    Characterization of acoustic shock wave will guarantee efficient tissue differentiation as feedback to reduce the probability of undesirable damaging (i.e. cutting) of tissues in laser surgery applications. We ablated hard (bone) and soft (muscle) tissues using a nanosecond pulsed Nd:YAG laser at 532 nm and a microsecond pulsed Er:YAG laser at 2.94 μm. When the intense short ns-pulsed laser is applied to material, the energy gain causes locally a plasma at the ablated spot that expands and propagates as an acoustic shock wave with a rarefaction wave behind the shock front. However, when using a μs-pulsed Er:YAG laser for material ablation, the acoustic shock wave is generated during the explosion of the ablated material. We measured and compared the emitted acoustic shock wave generated by a ns-pulsed Nd:YAG laser and a μs-pulsed Er:YAG laser measured by a calibrated microphone. As the acoustic shock wave attenuates as it propagates through air, the distance between ablation spots and a calibrated microphone was at 5 cm. We present the measurements on the propagation characteristics of the laser generated acoustic shock wave by measuring the arrival time-of-flight with a calibrated microphone and the energy-dependent evolution of acoustic parameters such as peak-topeak pressure, the ratio of the peak-to-peak pressures for the laser induced breakdown in air, the ablated muscle and the bone, and the spectral energy.

  20. Initial conditions of radiative shock experiments

    International Nuclear Information System (INIS)

    Kuranz, C. C.; Drake, R. P.; Krauland, C. M.; Marion, D. C.; Grosskopf, M. J.; Rutter, E.; Torralva, B.; Holloway, J. P.; Bingham, D.; Goh, J.; Boehly, T. R.; Sorce, A. T.

    2013-01-01

    We performed experiments at the Omega Laser Facility to characterize the initial, laser-driven state of a radiative shock experiment. These experiments aimed to measure the shock breakout time from a thin, laser-irradiated Be disk. The data are then used to inform a range of valid model parameters, such as electron flux limiter and polytropic γ, used when simulating radiative shock experiments using radiation hydrodynamics codes. The characterization experiment and the radiative shock experiment use a laser irradiance of ∼7 × 10 14 W cm −2 to launch a shock in the Be disk. A velocity interferometer and a streaked optical pyrometer were used to infer the amount of time for the shock to move through the Be disk. The experimental results were compared with simulation results from the Hyades code, which can be used to model the initial conditions of a radiative shock system using the CRASH code

  1. The Shock and Vibration Bulletin. Part 3. Machinery Dynamics, System Identification and Structural Analysis

    Science.gov (United States)

    1985-06-01

    purposes. 55 15 525 + 2 225L L53 + L3 ) + 2G3(L 2 + L35L4 + L45)" For the present system identification + 2G(L45 2 + L45L5 + L5 "L 1 technique, the...orbital model is comprised of 257 nodes and 819 dynamic:"DOF’s. k; were compared to ITD results for a wide variety of TD input parameters. Overall, the

  2. Shock to the System: Prevention of Mother-to-Child Transmission of HIV and Child Mortality

    OpenAIRE

    Nicholas Wilson

    2012-01-01

    This paper examines the effect of introducing a new HIV/AIDS service, prevention of mother-to-child transmission of HIV (PMTCT), on overall quality of prenatal and postnatal care. My results suggest that local PMTCT introduction in Zambia may have actually increased all cause child mortality in the short term. There is some evidence that vaccinations may have declined in the short term in association with local PMTCT introduction, suggesting that the new service may have partly crowded out ex...

  3. Simulation Study of Shock Reaction on Porous Material

    International Nuclear Information System (INIS)

    Xu Aiguo; Zhang Guangcai; Pan Xiaofei; Zhu Jianshi

    2009-01-01

    Direct modeling of porous materials under shock is a complex issue. We investigate such a system via the newly developed material-point method. The effects of shock strength and porosity size are the main concerns. For the same porosity, the effects of mean-void-size are checked. It is found that local turbulence mixing and volume dissipation are two important mechanisms for transformation of kinetic energy to heat. When the porosity is very small, the shocked portion may arrive at a dynamical steady state; the voids in the downstream portion reflect back rarefactive waves and result in slight oscillations of mean density and pressure; for the same value of porosity, a larger mean-void-size makes a higher mean temperature. When the porosity becomes large, hydrodynamic quantities vary with time during the whole shock-loading procedure: after the initial stage, the mean density and pressure decrease, but the temperature increases with a higher rate. The distributions of local density, pressure, temperature and particle-velocity are generally non-Gaussian and vary with time. The changing rates depend on the porosity value, mean-void-size and shock strength. The stronger the loaded shock, the stronger the porosity effects. This work provides a supplement to experiments for the very quick procedures and reveals more fundamental mechanisms in energy and momentum transportation. (general)

  4. Efficiency increase of complex production and transport systems management

    Directory of Open Access Journals (Sweden)

    Kornilov S.

    2017-01-01

    Full Text Available This article deals with the problem of the reduced efficiency of management in complex production - transport systems due to the lack of co-ordination in the operation of industrial enterprises and transport carrying out their maintenance. The existing transport service schedules for auxiliary departments do not take into account possible changes in operating conditions, the probability of malfunctions and the amount of reserves, which leads to an increase in general production costs. To solve this problem, we propose to use the interval regulation of production and transport processes in all departments of the complex production and transport systems. Also, such regulation involves the determination of traffic service priority. This will allow passing on from the regulated control of production and transport processes to the situational one, adapted to specific conditions, and reducing losses from untimely transport servicing, which will lead to a stores reduction and efficiency increase of the enterprise circulating facilities use. Testing the effectiveness of interval regulation was performed on the system and dynamics simulation model of liquid iron transportation in the oxygen converter shop of the metallurgical enterprise. It was established that the use of interval regulation processes in iron production and its transportation will allow decreasing non-productive downtime by 21% and the amount of the liquid iron in anticipation of recasting in the oxygen converter shop – by 33%. Economical effect of reducing the liquid iron downtime during transportation to the oxygen converter shop will be about 30 million rubles per year.

  5. MONETARY POLICY SHOCKS AND ISLAMIC BANKS DEPOSITS IN INDONESIAN DUAL BANKING SYSTEM AFTER THE FINANCIAL CRISIS

    Directory of Open Access Journals (Sweden)

    Ahmad Affandi

    2017-03-01

    Full Text Available Use of riba (usury in the economic system remained a key factor that led to financial crisis since theinception of modern economy in the late of 17th century. Implementation of interest based monetary policystipulated rampant speculation as common practices in the global financial sector. Although Islamic bankingwas governed by syariah (Divine Law, which was assumed to be resilient from distress, the volatility ofinterest movement would generally affect Islamic banks operations in a dual banking system. This paperwould look at this issue and would empirically explore the dynamic inter-relationships between deposits ofIslamic banks with monetary policy variables in Indonesia. In terms of market share, as of 2009, Islamicbanking asset in Indonesia was a meager 2%. The industry had been affected by few monetary policy shockson its deposits and financing. The study would employ vector auto regression model (VAR to explore thedynamics between the variables. The study would focus on data from 2004 to 2008 or performance after theAsian financial crisis. The results from these tests determined that shariah based deposits played significantrole in transmitting monetary policy effects to the economy. This study found that Islamic banking depositsin Indonesia were not sensitive to monetary policy changes. This study also concluded that IndonesianIslamic banks were resilient to financial crisis.

  6. Macroeconomic Evolution after a Production Shock: the Role for Financial Intermediation

    OpenAIRE

    Vinogradov, Dmitri V.

    2006-01-01

    Financial intermediaries may increase economic efficiency through intertemporal risk smoothing. However without an adequate regulation, intermediation may fail to do this. This paper studies the effects of a production shock in a closed economy and compares abilities of market-based and bank-based financial systems in processing the shock. Unregulated banking system may collapse in absence of a proper regulation. The paper studies several types of regulatory interventions, which may improve t...

  7. Increasing radiographer productivity by an incentive point system.

    Science.gov (United States)

    Williams, B; Chacko, P T

    1983-01-01

    Because of a very low technologist productivity in their Radiology Department, the authors describe a Productive Point System they developed and implemented to solve this personnel problem. After establishing the average time required to perform all exams, point credits (one point for every ten minutes utilized) were assigned to each exam performed, thereby determining an index of production. A Productive Index of 80% was considered realistic and was the equivalent of 192 points for a 40-hour work week. From 1975 to 1978 personal productivity increased from 79% to 113%. This resulted in an average yearly fiscal savings of over $20,000.00 for this three-year period. There was also a significant improvement in exam efficiency and quality, job attitude, personnel morale, and public relations. This program was highly successful because technologist acceptance and cooperation was complete, and this occurred mainly because the system supports the normal occupational goals and expectations of technologists.

  8. MICRO CREDIT SYSTEM FOR INCREASING FEMALEEMPLOYMENT AND ENTREPRENEURSHIP IN TURKEY

    Directory of Open Access Journals (Sweden)

    Şenol Yaprak

    2017-01-01

    Full Text Available Women labor participation rate is very low in Turkey. Although the governmentincentive policies have relatively improved, positive developments expected in thisarea have not taken place at the desired level. The micro-credit scheme aiming atproviding relatively smaller amount of loans to entrepreneur women to start theirbusiness began in 1980s in the world, and became operational in our country atthe beginning of 2000s. Currently, certain level of successful is observed throughin many Turkish provinces through this system. To this day, nearly 200thousandfemale entrepreneur established their business through small capital provided bythe micro credit system in Turkey. Moreover, they have already paid back all theloans that they used. In this study, the application of micro-credit system forincreasing female participation in labor force and business life is investigated.The labor participation level of women in Turkey has remained quite low.Although the government incentive policies have relatively provided improvement,the positive developmentsexpected in this area have not taken place at the desiredlevel. The micro-credit scheme aiming at providing relatively lower amount ofloans to women to start their business began in 1980s in the world, and becameoperational in our country at the beginning of 2000s. Currently, we see successfulwork is done through this scheme in many Turkish provinces. In this study, theapplication of micro-credit system for increasing the participation of women inworking life is elaborated.

  9. Increasing the information acquisition volume in iris recognition systems.

    Science.gov (United States)

    Barwick, D Shane

    2008-09-10

    A significant hurdle for the widespread adoption of iris recognition in security applications is that the typically small imaging volume for eye placement results in systems that are not user friendly. Separable cubic phase plates at the lens pupil have been shown to ameliorate this disadvantage by increasing the depth of field. However, these phase masks have limitations on how efficiently they can capture the information-bearing spatial frequencies in iris images. The performance gains in information acquisition that can be achieved by more general, nonseparable phase masks is demonstrated. A detailed design method is presented, and simulations using representative designs allow for performance comparisons.

  10. Adjustable Shock Absorbers

    OpenAIRE

    Adamiec, Radek

    2012-01-01

    Bakalářská práce obsahuje přehled používaných tlumičů osobních automobilů, závodních automobilů a motocyklů. Jsou zde popsány systémy t lumením, konstrukce tlumičů a vidlic používaných u motocyklů. Dále je zde přehled prvků používaných u podvozků automobilů. This bachelor´s thesis contains the survey of the shock absorbers of passenger cars, racing cars and motorcycles. Are described damping systems, the design used shock absorbers and forks for motorcycles. Then there is the list of the e...

  11. Pressurized thermal shock (PTS)

    International Nuclear Information System (INIS)

    Rosso, Ricardo D.; Ventura, Mirta A.

    2006-01-01

    In the present work, a description of Thermal Shock in Pressurized conditions (PTS), and its influence in the treatment of the integrity of the pressure vessel (RPV) of a Pressurized Water Reactor (PWR) and/or of a Heavy water Pressurized water Reactor (PHWR) is made. Generally, the analysis of PTS involves a process of three stages: a-) Modeling with a System Code of relevant thermohydraulics transients in reference with the thermal shock; b-) The local distribution of temperatures in the downcomer and the heat transference coefficients from the RPV wall to the fluid, are determined; c-) The fracture mechanical analysis. These three stages are included in this work: Results with the thermohydraulics code Relap5/mod.3, are obtained, for a LOCA scenario in the hot leg of the cooling System of the Primary System of the CAN-I reactor. The method used in obtaining results is described. A study on the basis of lumped parameters of the local evolutions of the temperature of the flow is made, in the downcomer of the reactor pressure vessel. The purpose of this study is to determine how the intensification of the stress coefficient, varies in function of the emergency injected water during the thermohydraulic transients that take place under the imposed conditions in the postulated scene. Specially, it is considered a 50 cm 2 break, located in the neighborhoods of the pressurized with the corresponding hot leg connection. This size is considered like the most critical. The method used to obtain the results is described. The fracture mechanical analysis is made. From the obtained results we confirmed that we have a simple tool of easy application in order to analyze phenomena of the type PTS in the postulated scenes by break in the cold and hot legs of the primary system. This methodology of calculus is completely independent of the used ones by the Nucleoelectrica Argentina S.A. (NASA) in the analysis of the PTS phenomena in the CAN-I. The results obtained with the adopted

  12. A FOCUSED TRANSPORT APPROACH TO THE TIME-DEPENDENT SHOCK ACCELERATION OF SOLAR ENERGETIC PARTICLES AT A FAST TRAVELING SHOCK

    International Nuclear Information System (INIS)

    Le Roux, J. A.; Webb, G. M.

    2012-01-01

    Some of the most sophisticated models for solar energetic particle (SEP) acceleration at coronal mass ejection driven shocks are based on standard diffusive shock acceleration theory. However, this theory, which only applies when SEP pitch-angle anisotropies are small, might have difficulty in describing first-order Fermi acceleration or the shock pre-heating and injection of SEPs into first-order Fermi acceleration accurately at lower SEP speeds where SEP pitch-angle anisotropies upstream near the shock can be large. To avoid this problem, we use a time-dependent focused transport model to reinvestigate first-order Fermi acceleration at planar parallel and quasi-parallel spherical traveling shocks between the Sun and Earth with high shock speeds associated with rare extreme gradual SEP events. The focused transport model is also used to investigate and compare three different shock pre-heating mechanisms associated with different aspects of the nonuniform cross-shock solar wind flow, namely, the convergence of the flow (adiabatic compression), the shear tensor of the flow, and the acceleration of the flow, and a fourth shock pre-heating mechanism associated with the cross-shock electric field, to determine which pre-heating mechanism contributes the most to injecting shock pre-heated source particles into the first-order Fermi acceleration process. The effects of variations in traveling shock conditions, such as increasing shock obliquity and shock slowdown, and variations in the SEP source with increasing shock distance from the Sun on the coupled processes of shock pre-heating, injection, and first-order Fermi acceleration are analyzed. Besides the finding that the cross-shock acceleration of the solar wind flow yields the dominant shock pre-heating mechanism at high shock speeds, we find that first-order Fermi acceleration at fast traveling shocks differs in a number of respects from the predictions and assumptions of standard steady-state diffusive shock

  13. INTERFERENCE OF COUNTERPROPAGATING SHOCK WAVES

    Directory of Open Access Journals (Sweden)

    P. V. Bulat

    2015-03-01

    Full Text Available The subject of study. We examined the interaction of counterpropagating shock waves. The necessity of counterpropagating shock waves studying occurs at designing of high Mach number modern internal compression air intakes, Ramjets with subsonic and supersonic combustion, in asymmetrical supersonic nozzles and in some other cases. In a sense, this problem is a generalization of the case of an oblique shock reflection from the wall or from the plane of symmetry. With the renewed vigor, the interest to this problem emerged at the end of the 90s. This was due to the start of the programs for flight study at hypersonic speeds. The first experiments performed with air intakes, which realized the interaction of counterpropagating shock waves have shown that the change in flow velocity is accompanied by abrupt alteration of shock-wave structure, the occurrence of nonstationary and oscillatory phenomena. With an increase of flow velocity these phenomena undesirable for aircraft structure became more marked. The reason is that there are two fundamentally different modes of interaction of counterpropagating shock waves: a four-wave regular and a five-wave irregular. The transition from one mode to another can be nonstationary abrupt or gradual, it can also be accompanied by hysteresis. Main results. Criteria for the transition from regular reflection of counterpropagating shock waves to irregular are described: the criterion of von Neumann and the stationary Mach configuration criterion. We described areas in which the transition from one reflection type to another is possible only in abrupt way, as well as areas of possible gradual transition. Intensity dependences of the reflected shock waves from the intensity of interacting counterpropagating shocks were given. Qualitative pictures of shock-wave structures arising from the interaction of counterpropagating shock waves were shown. Calculation results of the intensity of outgoing gas

  14. Study of a nonlinear system with shocks under broadband excitation. Application to a steam generator tube

    International Nuclear Information System (INIS)

    Thenint, Th.

    2011-01-01

    The steam generator is a heat exchanger and participates to the nuclear safety. Energy is transferred from the primary to the secondary fluid through many U-tubes maintained vertically by support plates. A sludge deposit tends to modify the boundary conditions and the secondary fluid flow. A fluid-elastic instability can then occur and lead to quick tube ruin. This thesis seeks a better understanding of the effect of contact nonlinearity on the dynamics of a tube in-air intermittently impacting the support plates and its consequences in regards with instability. The use of discretized contact conditions with circular obstacles distributed over the thickness of the plates and the use of enriched reduction bases allow quick and relevant nonlinear numerical simulations. These simulations are well correlated with experimental measurements and valid even with strong nonlinearity or negative modal damping. The evolution of power spectral densities (PSD) with growing excitation amplitude is analyzed: padding of the anti-resonances, peak shift and spread. It is then shown that an apparent stiffness associated with a permanent bilateral contact is pertinent to describe these transitions. In the case of an unstable linear system, one demonstrates that the nonlinearity keeps the responses bounded or stabilised, thus paving the way for future work with real or simulated fluid flows. (author)

  15. Technique for Increasing Accuracy of Positioning System of Machine Tools

    Directory of Open Access Journals (Sweden)

    Sh. Ji

    2014-01-01

    Full Text Available The aim of research is to improve the accuracy of positioning and processing system using a technique for optimization of pressure diagrams of guides in machine tools. The machining quality is directly related to its accuracy, which characterizes an impact degree of various errors of machines. The accuracy of the positioning system is one of the most significant machining characteristics, which allow accuracy evaluation of processed parts.The literature describes that the working area of the machine layout is rather informative to characterize the effect of the positioning system on the macro-geometry of the part surfaces to be processed. To enhance the static accuracy of the studied machine, in principle, two groups of measures are possible. One of them points toward a decrease of the cutting force component, which overturns the slider moments. Another group of measures is related to the changing sizes of the guide facets, which may lead to their profile change.The study was based on mathematical modeling and optimization of the cutting zone coordinates. And we find the formula to determine the surface pressure of the guides. The selected parameters of optimization are vectors of the cutting force and values of slides and guides. Obtained results show that a technique for optimization of coordinates in the cutting zone was necessary to increase a processing accuracy.The research has established that to define the optimal coordinates of the cutting zone we have to change the sizes of slides, value and coordinates of applied forces, reaching the pressure equalization and improving the accuracy of positioning system of machine tools. In different points of the workspace a vector of forces is applied, pressure diagrams are found, which take into account the changes in the parameters of positioning system, and the pressure diagram equalization to provide the most accuracy of machine tools is achieved.

  16. Collisionless electrostatic shocks

    DEFF Research Database (Denmark)

    Andersen, H.K.; Andersen, S.A.; Jensen, Vagn Orla

    1970-01-01

    An attempt was made in the laboratory to observe the standing collisionless electrostatic shocks in connection with the bow shock of the earth......An attempt was made in the laboratory to observe the standing collisionless electrostatic shocks in connection with the bow shock of the earth...

  17. Plasma control system upgrade and increased plasma stability in NSTX

    Energy Technology Data Exchange (ETDEWEB)

    Mastrovito, D., E-mail: dmastrovito@pppl.go [Princeton Plasma Physics Laboratory, P.O. Box 451 Princeton, NJ 08543 (United States); Gates, D.; Gerhard, S.; Lawson, J.; Ludescher-Furth, C.; Marsala, R. [Princeton Plasma Physics Laboratory, P.O. Box 451 Princeton, NJ 08543 (United States)

    2010-07-15

    Plasma control on the National Spherical Torus Experiment (NSTX) was previously accomplished using eight 333 MHz G4 processors built by Sky computers. Several planned improvements and additional control algorithms required significant upgrades to our real-time control computers and real-time data acquisition infrastructure. Several in-house modules have been designed and implemented including: the digital time stamp module (DITS) and for digital/analog front panel data port (FPDP) output, the FPDP output module digital/analog (FOMD/A). Standard Linux based Intel computers perform the real-time control tasks and InfiniBand as been employed for communication between a user-accessible 'host' server and the real-time computer. In addition to several independent real-time processes the General Atomics developed PCS (Bell (2006) ) system infrastructure continues to be used on NSTX. While maintaining previous functionality, improvements in the control system software include: an RWM feedback algorithm, beta feedback NBI control, more comprehensive error logging and trapping, more user-friendly interface, more complete archiving and restoring functionality, and better status reporting and diagnostic tools. Once completed, we succeeded in increasing overall plasma stability and decreasing control system latency by several times.

  18. Magnetic field overshoots in the Venus blow shock

    International Nuclear Information System (INIS)

    Tatrallyay, M.; Luhmann, J.G.; Russell, C.T.

    1984-01-01

    An examination of Pioneer Venus Orbiter fluxgate magnetometer data has shown that magnetic field overshoots occur not only behind quasi-perpendicular bow shocks but also behind quasi-parallel shocks. Overshoots are assocciated only with supercritical shocks. Their amplitudes increase with increasing fast Mach number. Solar wind beta has a lesser effect. The thickness of the overshoot increases with decreasing Theta-BN. The thickness of apparent overshoots detected behind 4 strong fast interplanetary shocks (M greater than M/crit) is about 3 orders of magnitude larger. Multiple crossings of the Venus bow shock were observed mainly at turbulent shocks. Their occurence is not influenced by Theta-BN. 15 references

  19. Electron velocity distributions near collisionless shocks

    International Nuclear Information System (INIS)

    Feldman, W.C.

    1984-01-01

    Recent studies of the amount of electron heating and of the shapes of electron velocity distributions across shocks near the earth are reviewed. It is found that electron heating increases with increasing shock strength but is always less than the ion heating. The scale length of electron heating is also less than that for the ions. Electron velocity distributions show characteristic shapes which depend on the strength of the shocks. At the weaker shocks, electron heating is mostly perpendicular to the ambient magnetic field, bar B, and results in Gaussian-shaped velocity distributions at low-to-moderate energies. At the stronger shocks, parallel heating predominates resulting in flat-topped velocity distributions. A reasonable interpretation of these results indicates that at the weaker shocks electron heating is dominated by a tendency toward conservation of the magnetic moment. At the stronger fast-mode shocks, this heating is thought to be dominated by an acceleration parallel to bar B produced by the macroscopic shock electric field followed by beam driven plasma instabilities. Some contribution to the heating at the stronger shocks from conservation of the magnetic moment and cross-field current-driven instabilities cannot be ruled out. Although the heating at slow-mode shocks is also dominated by instabilities driven by magnetic field-aligned electron beams, their acceleration mechanism is not yet established

  20. Shock parameter calculations at weak interplanetary shock waves

    Directory of Open Access Journals (Sweden)

    J. M. Gloag

    2005-02-01

    Full Text Available A large set of interplanetary shock waves observed using the Ulysses spacecraft is analysed in order to determine their local parameters. For the first time a detailed analysis is extended to the thermodynamic properties of a large number of events. The intention is to relate the shock parameters to the requirements set by MHD shock theory. A uniform approach is adopted in the selection of up and downstream regions for this analysis and applied to all the shock waves. Initially, the general case of a 3 component adiabatic plasma is considered. However, the calculation of magnetosonic and Alfvénic Mach numbers and the ratio of downstream to upstream entropy produce some unexpected results. In some cases there is no clear increase in entropy across the shock and also the magnetosonic Mach number can be less than 1. It is found that a more discerning use of data along with an empirical value for the polytropic index can raise the distribution of downstream to upstream entropy ratios to a more acceptable level. However, it is also realised that many of these shocks are at the very weakest end of the spectrum and associated phenomena may also contribute to the explanation of these results.

  1. The implications of an increasingly decentralised energy system

    International Nuclear Information System (INIS)

    Wolfe, Philip

    2008-01-01

    The UK government has signalled that the increasing use of decentralised energy forms part of its plan to achieve the UK's contribution to the EU's sustainable energy targets. Much of the technology for decentralised energy already exists, although it is not widely used in the UK. There will be need for new developments in onsite energy production, and in the delivery, integration and regulatory infrastructure to support it. Other State of Science reviews for this project describe particular energy technologies, but this paper highlights selected developments in thermal technologies and in biological processes which offer the potential for breakthroughs in converting biomass to energy. The effectiveness and deployment of decentralised energy can be enhanced by systems and infrastructure technology, not just for electricity but also in heat and biogas networks. Such systems are expected to be a focus of rapid development over the next two decades. Opportunities exist particularly in active networks, smart metering and intelligent tariff-interactive load management. Substantial regulatory and policy reform will be required to optimise the potential for onsite energy generation and effective two-way interchanges with centralised energy systems. There will be need for a regulatory system for heat networks and appropriate incentives for active networks. The development of an energy services business model in the industry will not progress until the compensation model changes to make it viable. The strength of the drivers for a trend towards decentralised energy, coupled with a wide range of scientific developments, should make this a very dynamic sector and present a host of new opportunities for British technology

  2. Experimental investigation of shock wave - bubble interaction

    Energy Technology Data Exchange (ETDEWEB)

    Alizadeh, Mohsen

    2010-04-09

    expanded beam of a Q-switched laser pulse at wavelength of λ=532 nm and with pulse duration of ∼4 ns is focused at the center of a water tank using an aberration minimized lens design. Single cavitation bubbles are initiated via optical breakdown at this location which coincides with the position of which the shock wave is focused. The energy of the shock wave source has been altered in 8 steps. The pressure pulse amplitude of the impinging shock wave measured at the distance of about 1.8 mm above the focus location range from 24.4 MPa to 108.1 MPa. The lithotripter shock wave impact time is varied in three steps which provides the possibility of investigation of the bubble dynamics in both cases of collapsing and expanding cavities at the moment of the shock wave impingement. After the shock wave impact, the bubble spherical symmetry is broken and a liquid jet develops in the original direction of the shock propagation. The speed of the jet is increasing with the shock wave energy. Due to the energy transfer from the shock wave to the bubble, the forced cavity implosion is more violent in comparison to free oscillation. The pressure pulse amplitude released from the forced bubble collapse is amplified and the collapse time is reduced. These effects are discussed in chapter 5. Generally, when the bubble is collapsing at the time of the shock impact, the forced cavity collapse is more violent with a resultant of more pressure enhancement compared to the expanding bubbles at the moment of the shock arrival. The maximum pressure enhancement and reduction of bubble collapse time occur when the time interval between the moments of the shock impact and bubble collapse approaches the pulse duration of the compression part of the shock wave profile (i.e. ∼1 μs). For each specific shock wave arrival time, increasing the shock intensity leads to the fact that the bubble collapse takes place earlier relative to the moment of the shock impact and having more collapse pressure

  3. Color management systems: methods and technologies for increased image quality

    Science.gov (United States)

    Caretti, Maria

    1997-02-01

    All the steps in the imaging chain -- from handling the originals in the prepress to outputting them on any device - - have to be well calibrated and adjusted to each other, in order to reproduce color images in a desktop environment as accurate as possible according to the original. Today most of the steps in the prepress production are digital and therefore it is realistic to believe that the color reproduction can be well controlled. This is true thanks to the last years development of fast, cost effective scanners, digital sources and digital proofing devices not the least. It is likely to believe that well defined tools and methods to control this imaging flow will lead to large cost and time savings as well as increased overall image quality. Until now, there has been a lack of good, reliable, easy-to- use systems (e.g. hardware, software, documentation, training and support) in an extent that has made them accessible to the large group of users of graphic arts production systems. This paper provides an overview of the existing solutions to manage colors in a digital pre-press environment. Their benefits and limitations are discussed as well as how they affect the production workflow and organization. The difference between a color controlled environment and one that is not is explained.

  4. Splenectomy increases the subsequent risk of systemic lupus erythematosus.

    Science.gov (United States)

    Hsu, Chao-Yu; Chen, Hsuan-Ju; Hsu, Chung Y; Kao, Chia-Hung

    2016-02-01

    Splenectomy may be necessary to treat systemic lupus erythematosus (SLE) patients with thrombocytopenia; however, whether performing a splenectomy on patients without SLE increases the subsequent risk of SLE remains unknown. Therefore, this study was conducted to determine the association between splenectomy and SLE. We conducted a cohort study by using data from the Taiwan National Health Institute Research Database to identify 10,298 patients with received a splenectomy between 2000 and 2006 and 41,192 participants without received a splenectomy who were selected by frequency matched based on sex, age, and the index year. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95 % confidence intervals (CIs) of developing SLE associated with splenectomy compared with patients who did not receive a splenectomy. During the study period, the overall incidence density rate of SLE was higher in the splenectomy cohort than in the non-splenectomy cohort (adjusted HR 10.55; 95 % CI 50.55-20.05). The incidence density rates of SLE in women and men who received a splenectomy were higher than those of patients who did not receive a splenectomy. Non-traumatic splenectomy increases the subsequent risk of SLE. The risk of SLE should be considered before performing a splenectomy, particularly in women and younger patients.

  5. Sepsis and Septic Shock Strategies.

    Science.gov (United States)

    Armstrong, Bracken A; Betzold, Richard D; May, Addison K

    2017-12-01

    Three therapeutic principles most substantially improve organ dysfunction and survival in sepsis: early, appropriate antimicrobial therapy; restoration of adequate cellular perfusion; timely source control. The new definitions of sepsis and septic shock reflect the inadequate sensitivity, specify, and lack of prognostication of systemic inflammatory response syndrome criteria. Sequential (sepsis-related) organ failure assessment more effectively prognosticates in sepsis and critical illness. Inadequate cellular perfusion accelerates injury and reestablishing perfusion limits injury. Multiple organ systems are affected by sepsis and septic shock and an evidence-based multipronged approach to systems-based therapy in critical illness results in improve outcomes. Copyright © 2017 Elsevier Inc. All rights reserved.

  6. Essential amino acid enriched high-protein enteral nutrition modulates insulin-like growth factor-1 system function in a rat model of trauma-hemorrhagic shock.

    Directory of Open Access Journals (Sweden)

    Xianfeng Xia

    Full Text Available Nutrition support for critically ill patients supplemented with additional modular protein may promote skeletal muscle protein anabolism in addition to counteracting acute nitrogen loss. The present study was designed to investigate whether the essential amino acid (EAA enriched high-protein enteral nutrition (EN modulates the insulin-like growth factor-1 (IGF-1 system and activates the mammalian target of rapamycin (mTOR anabolic signaling pathway in a trauma-hemorrhagic shock (T-HS rat model.Male Sprague-Dawley rats (n = 90, 278.18 ± 0.94 g were randomly assigned to 5 groups: (1 normal control, (2 pair-fed, (3 T-HS, (4 T-HS and standard EN, and (5 T-HS and EAA enriched high-protein EN. Six animals from each group were harvested on days 2, 4, and 6 for serum, gastrocnemius, soleus, and extensor digitorum longus sample collection. T-HS significantly reduced muscle mass. Nutrition support maintained muscle mass, especially the EAA enriched high-protein EN. Meanwhile, a pronounced derangement in IGF-1-IGFBPs axis as well as impaired mTOR transduction was observed in the T-HS group. Compared with animals receiving standard EN, those receiving EAA enriched high-protein EN presented 18% higher serum free IGF-1 levels following 3 days of nutrition support and 22% higher after 5 days. These changes were consistent with the concomitant elevation in serum insulin and reduction in corticosterone levels. In addition, phosphorylations of downstream anabolic signaling effectors - including protein kinase B, mTOR, and ribosomal protein S6 kinase1 - increased significantly in rats receiving EAA enriched high-protein EN.Our findings firstly demonstrate the beneficial effect of EAA enriched high-protein EN on the metabolic modulation of skeletal muscle protein anabolism by regulating the IGF-1 system and downstream anabolic signaling transduction.

  7. Reserves and Trade Jointly Determine Exposure to Food Supply Shocks

    Science.gov (United States)

    Marchand, Philippe; Carr, Joel A.; Dell'Angelo, Jampel; Fader, Marianela; Gephart, Jessica A.; Kummu, Matti; Magliocca, Nicholas; Porkka, Miina; Puma, Michael J.; Zak, Ratajczak

    2016-01-01

    While a growing proportion of global food consumption is obtained through international trade, there is an ongoing debate on whether this increased reliance on trade benefits or hinders food security, and specifically, the ability of global food systems to absorb shocks due to local or regional losses of production. This paper introduces a model that simulates the short-term response to a food supply shock originating in a single country, which is partly absorbed through decreases in domestic reserves and consumption, and partly transmitted through the adjustment of trade flows. By applying the model to publicly-available data for the cereals commodity group over a 17 year period, we find that differential outcomes of supply shocks simulated through this time period are driven not only by the intensification of trade, but as importantly by changes in the distribution of reserves. Our analysis also identifies countries where trade dependency may accentuate the risk of food shortages from foreign production shocks; such risk could be reduced by increasing domestic reserves or importing food from a diversity of suppliers that possess their own reserves. This simulation-based model provides a framework to study the short-term, nonlinear and out-of-equilibrium response of trade networks to supply shocks, and could be applied to specific scenarios of environmental or economic perturbations.

  8. Systemic inflammatory response syndrome increases immobility-induced neuromuscular weakness.

    Science.gov (United States)

    Fink, Heidrun; Helming, Marc; Unterbuchner, Christoph; Lenz, Andrea; Neff, Frauke; Martyn, J A Jeevendra; Blobner, Manfred

    2008-03-01

    Inflammation and immobility are comorbid etiological factors inducing muscle weakness in critically ill patients. This study establishes a rat model to examine the effect of inflammation and immobilization alone and in combination on muscle contraction, histology, and acetylcholine receptor regulation. Prospective, randomized, experimental study. Animal laboratory of a university hospital. Sprague-Dawley rats. To produce systemic inflammation, rats (n = 34) received three consecutive intravenous injections of Corynebacterium parvum on days 0, 4, and 8. Control rats (n = 21) received saline. Both groups were further divided to have one hind limb either immobilized by pinning of knee and ankle joints or sham-immobilized (surgical leg). The contralateral nonsurgical leg of each animal served as control (nonsurgical leg). After 12 days, body weight and muscle mass were significantly reduced in all C. parvum animals compared with saline-injected rats. Immobilization led to local muscle atrophy. Normalized to muscle mass, tetanic contraction was reduced in the surgical leg after immobilization (7.64 +/- 1.91 N/g) and after inflammation (8.71 +/- 2.0 N/g; both p < .05 vs. sham immobilization and saline injection, 11.03 +/- 2.26 N/g). Histology showed an increase in inflammatory cells in all C. parvum-injected animals. Immobilization in combination with C. parvum injection had an additive effect on inflammation. Acetylcholine receptors were increased in immobilized muscles and in all muscles of C. parvum-injected animals. The muscle weakness in critically ill patients can be replicated in our novel rat model. Inflammation and immobilization independently lead to muscle weakness.

  9. Entropy Generation Across Earth's Bow Shock

    Science.gov (United States)

    Parks, George K.; McCarthy, Michael; Fu, Suiyan; Lee E. s; Cao, Jinbin; Goldstein, Melvyn L.; Canu, Patrick; Dandouras, Iannis S.; Reme, Henri; Fazakerley, Andrew; hide

    2011-01-01

    Earth's bow shock is a transition layer that causes an irreversible change in the state of plasma that is stationary in time. Theories predict entropy increases across the bow shock but entropy has never been directly measured. Cluster and Double Star plasma experiments measure 3D plasma distributions upstream and downstream of the bow shock that allow calculation of Boltzmann's entropy function H and his famous H-theorem, dH/dt O. We present the first direct measurements of entropy density changes across Earth's bow shock. We will show that this entropy generation may be part of the processes that produce the non-thermal plasma distributions is consistent with a kinetic entropy flux model derived from the collisionless Boltzmann equation, giving strong support that solar wind's total entropy across the bow shock remains unchanged. As far as we know, our results are not explained by any existing shock models and should be of interests to theorists.

  10. Increased systemic vascular resistance in neonates with pulmonary hypertension.

    Science.gov (United States)

    Milstein, J M; Goetzman, B W; Riemenschneider, T A; Wennberg, R P

    1979-11-01

    The time necessary for aortic diastolic pressure to decrease to 50 percent of an initially selected value after dissipation of the dicrotic notch (T 1/2) was determined in newborn infants with and without pulmonary hypertension. The mean T 1/2 was 671 +/- 167 msec in seven infants with clinical evidence of pulmonary hypertension and documented right to left ductus arteriosus shunting; 849 +/- 243 msec in nine infants with clinical evidence of pulmonary hypertension but no documented right to left ductus arteriosus shunting; and 457 +/- 66 msec in eight infants with hyaline membrane disease and no clinical evidence of pulmonary hypertension or a patent ductus arteriosus. The mean T 1/2 values in the former two groups were significantly different from that in the group with no pulmonary hypertension (P less than 0.01). An evaluation of factors affecting T 1/2 leads to the conclusion that the patients with pulmonary hypertension had increased systemic vascular resistance as well. This finding has important diagnostic, etiologic and therapeutic implications.

  11. 21 CFR 876.5990 - Extracorporeal shock wave lithotripter.

    Science.gov (United States)

    2010-04-01

    ..., control console, imaging/localization system, and patient table. Prior to treatment, the urinary stone is targeted using either an integral or stand-alone localization/imaging system. Shock waves are typically... shock wave lithotripter. (a) Identification. An extracorporeal shock wave lithotripter is a device that...

  12. Fluid Replacement in Treatment of Hypovolemia and Shock: Crystalloids and Colloids

    Directory of Open Access Journals (Sweden)

    Fatih Yildiz

    2013-06-01

    Full Text Available Shock is a pathologic state with high mortality rate and characterized by a reduction of systemic tissue perfusion and decresead oxygen delivery. Absolute or relative hypovolemia is a common pathology of most shock types. Correction of hypovolemia might reverse the disturbance and increase the tissue perfusion. Fluid resuscitation with crystalloid and colloid solutions can carry the risk of increasing morbidity and mortality if not used properly. Although crystalloid and colloid solutions are considered to have equal efficacy and safety profile, recent studies showed that this assumption may not be correct. Early and effective management of hypovolemia is the cornerstone of shock resuscitation. Initial management of patients with septic shock and hypovolemia should be done with 30ml/kg of crystalloids. Proper fluid replacement and resuscitation algoritms might increase the survival rate. [Archives Medical Review Journal 2013; 22(3.000: 347-361

  13. Influence of interface scattering on shock waves in heterogeneous solids

    International Nuclear Information System (INIS)

    Zhuang Shiming; Ravichandran, Guruswami; Grady, Dennis E.

    2002-01-01

    In heterogeneous media, the scattering due to interfaces between dissimilar materials play an important role in shock wave dissipation and dispersion. In this work the influence of interface scattering effect on shock waves was studied by impacting flyer plates onto periodically layered polycarbonate/6061 aluminum, polycarbonate/304 stainless steel and polycarbonate/glass composites. The experimental results (using VISAR and stress gauges) indicate that the rise time of the shock front decreases with increasing shock strength, and increases with increasing mechanical impedance mismatch between layers; the strain rate at the shock front increases by about the square of the shock stress. Experimental and numerical results also show that due to interface scattering effect the shock wave velocity in periodically layered composites decreases. In some cases the shock velocity of a layered heterogeneous composite can be lower than that of either of its components

  14. The Finnish EMU Buffers and the Labour Market under Asymmetric Shocks

    OpenAIRE

    Alho, Kari

    2004-01-01

    The Finnish EMU buffers consist of elements built into the unemployment insurance and employment pension systems, which aim to stabilise employer contributions and employment during economic fluctuations in the EMU age. The paper simulates the role of these buffers in a hypothetical recession caused by an adverse asymmetric shock. The results show that the buffers play only a modest role in stabilising employment, although their importance increases as the shocks to the economy become greater...

  15. Finite Element Modeling of Material Fatigue and Cracking Problems for Steam Power System HP Devices Exposed to Thermal Shocks

    Directory of Open Access Journals (Sweden)

    Pawlicki Jakub

    2016-09-01

    Full Text Available The paper presents a detailed analysis of the material damaging process due to low-cycle fatigue and subsequent crack growth under thermal shocks and high pressure. Finite Element Method (FEM model of a high pressure (HP by-pass valve body and a steam turbine rotor shaft (used in a coal power plant is presented. The main damaging factor in both cases is fatigue due to cycles of rapid temperature changes. The crack initiation, occurring at a relatively low number of load cycles, depends on alternating or alternating-incremental changes in plastic strains. The crack propagation is determined by the classic fracture mechanics, based on finite element models and the most dangerous case of brittle fracture. This example shows the adaptation of the structure to work in the ultimate conditions of high pressure, thermal shocks and cracking.

  16. Advanced and Exploratory Shock Sensing Mechanisms.

    Energy Technology Data Exchange (ETDEWEB)

    Nelsen, Nicholas H. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Kolb, James D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Kulkarni, Akshay G. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Sorscher, Zachary [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Habing, Clayton D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Mathis, Allen [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Beller, Zachary J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-09-01

    Mechanical component response to shock environments must be predictable in order to ensure reliability and safety. Whether the shock input results from accidental drops during transportation to projectile impact scenarios, the system must irreversibly transition into a safe state that is incapable of triggering the component . With this critical need in mind, the 2017 Nuclear Weapons Summer Product Realization Institute (NW SPRINT) program objective sought the design of a passive shock failsafe with emphasis on additively manufactured (AM) components. Team Advanced and Exploratory (A&E) responded to the challenge by designing and delivering multiple passive shock sensing mech anisms that activate within a prescribed mechanical shock threshold. These AM failsafe designs were tuned and validated using analytical and computational techniques including the shock response spectrum (SRS) and finite element analysis (FEA). After rapid prototyping, the devices experienced physical shock tests conducted on Sandia drop tables to experimentally verify performance. Keywords: Additive manufacturing, dynamic system, failsafe, finite element analysis, mechanical shock, NW SPRINT, shock respon se spectrum

  17. Methods of increasing efficiency and maintainability of pipeline systems

    Science.gov (United States)

    Ivanov, V. A.; Sokolov, S. M.; Ogudova, E. V.

    2018-05-01

    This study is dedicated to the issue of pipeline transportation system maintenance. The article identifies two classes of technical-and-economic indices, which are used to select an optimal pipeline transportation system structure. Further, the article determines various system maintenance strategies and strategy selection criteria. Meanwhile, the maintenance strategies turn out to be not sufficiently effective due to non-optimal values of maintenance intervals. This problem could be solved by running the adaptive maintenance system, which includes a pipeline transportation system reliability improvement algorithm, especially an equipment degradation computer model. In conclusion, three model building approaches for determining optimal technical systems verification inspections duration were considered.

  18. Alterations of Mg2+ After Hemorrhagic Shock.

    Science.gov (United States)

    Lee, Mun-Young; Yang, Dong Kwon; Kim, Shang-Jin

    2017-11-01

    Hemorrhagic shock is generally characterized by hemodynamic instability with cellular hypoxia and diminishing cellular function, resulting from an imbalance between systemic oxygen delivery and consumption and redistribution of fluid and electrolytes. Magnesium (Mg) is the fourth most abundant cation overall and second most abundant intracellular cation in the body and an essential cofactor for the energy production and cellular metabolism. Data for blood total Mg (tMg; free-ionized, protein-bound, and anion-bound forms) and free Mg 2+ levels after a traumatic injury are inconsistent and only limited information is available on hemorrhagic effects on free Mg 2+ as the physiologically active form. The aim of this study was to determine changes in blood Mg 2+ and tMg after hemorrhage in rats identifying mechanism and origin of the changes in blood Mg 2+ . Hemorrhagic shock produced significant increases in blood Mg 2+ , plasma tMg, Na + , K + , Cl - , anion gap, partial pressures of oxygen, glucose, and blood urea nitrogen but significant decreases in RBC tMg, blood Ca 2+ , HCO 3 - , pH, partial pressures of carbon dioxide, hematocrit, hemoglobin, total cholesterol, and plasma/RBC ATP. During hemorrhagic shock, K + , anion gap, and BUN showed significant positive correlations with changes in blood Mg 2+ level, while Ca 2+ , pH, and T-CHO correlated to Mg 2+ in a negative manner. In conclusion, hemorrhagic shock induced an increase in both blood-free Mg 2+ and tMg, resulted from Mg 2+ efflux from metabolic damaged cell with acidosis and ATP depletion.

  19. Clustering execution in a processing system to increase power savings

    Energy Technology Data Exchange (ETDEWEB)

    Bose, Pradip; Buyuktosunoglu, Alper; Jacobson, Hans M.; Vega, Augusto J.

    2018-04-03

    Embodiments relate to clustering execution in a processing system. An aspect includes accessing a control flow graph that defines a data dependency and an execution sequence of a plurality of tasks of an application that executes on a plurality of system components. The execution sequence of the tasks in the control flow graph is modified as a clustered control flow graph that clusters active and idle phases of a system component while maintaining the data dependency. The clustered control flow graph is sent to an operating system, where the operating system utilizes the clustered control flow graph for scheduling the tasks.

  20. Clustering execution in a processing system to increase power savings

    Science.gov (United States)

    Bose, Pradip; Buyuktosunoglu, Alper; Jacobson, Hans M.; Vega, Augusto J.

    2018-03-20

    Embodiments relate to clustering execution in a processing system. An aspect includes accessing a control flow graph that defines a data dependency and an execution sequence of a plurality of tasks of an application that executes on a plurality of system components. The execution sequence of the tasks in the control flow graph is modified as a clustered control flow graph that clusters active and idle phases of a system component while maintaining the data dependency. The clustered control flow graph is sent to an operating system, where the operating system utilizes the clustered control flow graph for scheduling the tasks.

  1. Miniature shock tube for laser driven shocks.

    Science.gov (United States)

    Busquet, Michel; Barroso, Patrice; Melse, Thierry; Bauduin, Daniel

    2010-02-01

    We describe in this paper the design of a miniature shock tube (smaller than 1 cm(3)) that can be placed in a vacuum vessel and allows transverse optical probing and longitudinal backside extreme ultraviolet emission spectroscopy in the 100-500 A range. Typical application is the study of laser launched radiative shocks, in the framework of what is called "laboratory astrophysics."

  2. Are Credit Shocks Supply or Demand Shocks?

    OpenAIRE

    Bijapur, Mohan

    2013-01-01

    This paper provides new insights into the relationship between the supply of credit and the macroeconomy. We present evidence that credit shocks constitute shocks to aggregate supply in that they have a permanent effect on output and cause inflation to rise in the short term. Our results also suggest that the effects on aggregate supply have grown stronger in recent decades.

  3. Shock absorbing structure

    International Nuclear Information System (INIS)

    Kojima, Naoki; Matsushita, Kazuo.

    1992-01-01

    Small pieces of shock absorbers are filled in a space of a shock absorbing vessel which is divided into a plurality of sections by partitioning members. These sections function to prevent excess deformation or replacement of the fillers upon occurrence of falling accident. Since the shock absorbing small pieces in the shock absorbing vessel are filled irregularly, shock absorbing characteristics such as compression strength is not varied depending on the direction, but they exhibit excellent shock absorbing performance. They surely absorb shocks exerted on a transportation vessel upon falling or the like. If existing artificial fillers such as pole rings made of metal or ceramic and cut pieces such as alumium extrusion molding products are used as the shock absorbing pieces, they have excellent fire-proofness and cold resistance since the small pieces are inflammable and do not contain water. (T.M.)

  4. Melting under shock compression

    International Nuclear Information System (INIS)

    Bennett, B.I.

    1980-10-01

    A simple model, using experimentally measured shock and particle velocities, is applied to the Lindemann melting formula to predict the density, temperature, and pressure at which a material will melt when shocked from room temperature and zero pressure initial conditions

  5. Shock wave of vapor-liquid two-phase flow

    Institute of Scientific and Technical Information of China (English)

    Liangju ZHAO; Fei WANG; Hong GAO; Jingwen TANG; Yuexiang YUAN

    2008-01-01

    The shock wave of vapor-liquid two-phase flow in a pressure-gain steam injector is studied by build-ing a mathematic model and making calculations. The results show that after the shock, the vapor is nearly com-pletely condensed. The upstream Mach number and the volume ratio of vapor have a great effect on the shock. The pressure and Mach number of two-phase shock con-form to the shock of ideal gas. The analysis of available energy shows that the shock is an irreversible process with entropy increase.

  6. Biomass shock pretreatment

    Science.gov (United States)

    Holtzapple, Mark T.; Madison, Maxine Jones; Ramirez, Rocio Sierra; Deimund, Mark A.; Falls, Matthew; Dunkelman, John J.

    2014-07-01

    Methods and apparatus for treating biomass that may include introducing a biomass to a chamber; exposing the biomass in the chamber to a shock event to produce a shocked biomass; and transferring the shocked biomass from the chamber. In some aspects, the method may include pretreating the biomass with a chemical before introducing the biomass to the chamber and/or after transferring shocked biomass from the chamber.

  7. Mechanical analysis of a heat-shock induced developmental defect

    Science.gov (United States)

    Crews, Sarah M.; McCleery, W. Tyler; Hutson, M. Shane

    2014-03-01

    Embryonic development in Drosophila is a complex process involving coordinated movements of mechanically interacting tissues. Perturbing this system with a transient heat shock can result in a number of developmental defects. In particular, a heat shock applied during the earliest morphogenetic movements of gastrulation can lead to apparent recovery, but then subsequent morphogenetic failure 5-6 hours later during germ band retraction. The process of germ band retraction requires an intact amnioserosa - a single layered extra-embryonic epithelial tissue - and heat shock at gastrulation can induce the later opening of holes in the amnioserosa. These holes are highly correlated with failures of germ band retraction. These holes could be caused by a combination of mechanical weakness in the amnioserosa or local increases in mechanical stress. Here, we assess the role of mechanical stress using confocal imaging to compare cell and tissue morphology in the amnioserosa of normal and heat-shocked embryos and laser hole drilling to map the stress field around the times and locations at which heat-shock induced holes open.

  8. Increased Efficiency of Face Recognition System using Wireless Sensor Network

    Directory of Open Access Journals (Sweden)

    Rajani Muraleedharan

    2006-02-01

    Full Text Available This research was inspired by the need of a flexible and cost effective biometric security system. The flexibility of the wireless sensor network makes it a natural choice for data transmission. Swarm intelligence (SI is used to optimize routing in distributed time varying network. In this paper, SI maintains the required bit error rate (BER for varied channel conditions while consuming minimal energy. A specific biometric, the face recognition system, is discussed as an example. Simulation shows that the wireless sensor network is efficient in energy consumption while keeping the transmission accuracy, and the wireless face recognition system is competitive to the traditional wired face recognition system in classification accuracy.

  9. HUD INFORMATION SYSTEMS: Immature Software Acquisition Capability Increases Project Risks

    National Research Council Canada - National Science Library

    2001-01-01

    .... GAO has designated HUD's major program areas as high risk, in part because the department's information and financial management systems were poorly integrated, ineffective, and generally unreliable...

  10. The Impact of the Sepsis-3 Septic Shock Definition on Previously Defined Septic Shock Patients.

    Science.gov (United States)

    Sterling, Sarah A; Puskarich, Michael A; Glass, Andrew F; Guirgis, Faheem; Jones, Alan E

    2017-09-01

    The Third International Consensus Definitions Task Force (Sepsis-3) recently recommended changes to the definitions of sepsis. The impact of these changes remains unclear. Our objective was to determine the outcomes of patients meeting Sepsis-3 septic shock criteria versus patients meeting the "old" (1991) criteria of septic shock only. Secondary analysis of two clinical trials of early septic shock resuscitation. Large academic emergency departments in the United States. Patients with suspected infection, more than or equal to two systemic inflammatory response syndrome criteria, and systolic blood pressure less than 90 mm Hg after fluid resuscitation. Patients were further categorized as Sepsis-3 septic shock if they demonstrated hypotension, received vasopressors, and exhibited a lactate greater than 2 mmol/L. We compared in-hospital mortality in patients who met the old definition only with those who met the Sepsis-3 criteria. Four hundred seventy patients were included in the present analysis. Two hundred (42.5%) met Sepsis-3 criteria, whereas 270 (57.4%) met only the old definition. Patients meeting Sepsis-3 criteria demonstrated higher severity of illness by Sequential Organ Failure Assessment score (9 vs 5; p definition demonstrated significant mortality benefit following implementation of a quantitative resuscitation protocol (35% vs 10%; p = 0.006). In this analysis, 57% of patients meeting old definition for septic shock did not meet Sepsis-3 criteria. Although Sepsis-3 criteria identified a group of patients with increased organ failure and higher mortality, those patients who met the old criteria and not Sepsis-3 criteria still demonstrated significant organ failure and 14% mortality rate.

  11. Relativistic Shock Acceleration

    International Nuclear Information System (INIS)

    Duffy, P.; Downes, T.P.; Gallant, Y.A.; Kirk, J.G.

    1999-01-01

    In this paper we briefly review the basic theory of shock waves in relativistic hydrodynamics and magneto-hydrodynamics, emphasising some astrophysically interesting cases. We then present an overview of the theory of particle acceleration at such shocks describing the methods used to calculate the spectral indices of energetic particles. Recent results on acceleration at ultra-relativistic shocks are discussed. (author)

  12. Increasing Cropping System Diversity Balances Productivity, Profitability and Environmental Health

    Science.gov (United States)

    Davis, Adam S.; Hill, Jason D.; Chase, Craig A.; Johanns, Ann M.; Liebman, Matt

    2012-01-01

    Balancing productivity, profitability, and environmental health is a key challenge for agricultural sustainability. Most crop production systems in the United States are characterized by low species and management diversity, high use of fossil energy and agrichemicals, and large negative impacts on the environment. We hypothesized that cropping system diversification would promote ecosystem services that would supplement, and eventually displace, synthetic external inputs used to maintain crop productivity. To test this, we conducted a field study from 2003–2011 in Iowa that included three contrasting systems varying in length of crop sequence and inputs. We compared a conventionally managed 2-yr rotation (maize-soybean) that received fertilizers and herbicides at rates comparable to those used on nearby farms with two more diverse cropping systems: a 3-yr rotation (maize-soybean-small grain + red clover) and a 4-yr rotation (maize-soybean-small grain + alfalfa-alfalfa) managed with lower synthetic N fertilizer and herbicide inputs and periodic applications of cattle manure. Grain yields, mass of harvested products, and profit in the more diverse systems were similar to, or greater than, those in the conventional system, despite reductions of agrichemical inputs. Weeds were suppressed effectively in all systems, but freshwater toxicity of the more diverse systems was two orders of magnitude lower than in the conventional system. Results of our study indicate that more diverse cropping systems can use small amounts of synthetic agrichemical inputs as powerful tools with which to tune, rather than drive, agroecosystem performance, while meeting or exceeding the performance of less diverse systems. PMID:23071739

  13. New Commodity Services System increases gas bill for clients

    International Nuclear Information System (INIS)

    Koevoet, H.

    2003-01-01

    The Dutch company Gasunie Trade and Supply will replace the Commodity Services System (CDS, abbreviated in Dutch) January 1, 2004. This will result in a higher gas bill for almost all their clients that are expected to use more than 1 million m 3 natural gas per year. An overview is given of the principles of the old and the new pricing system [nl

  14. Shock Initiation of Damaged Explosives

    Energy Technology Data Exchange (ETDEWEB)

    Chidester, S K; Vandersall, K S; Tarver, C M

    2009-10-22

    Explosive and propellant charges are subjected to various mechanical and thermal insults that can increase their sensitivity over the course of their lifetimes. To quantify this effect, shock initiation experiments were performed on mechanically and thermally damaged LX-04 (85% HMX, 15% Viton by weight) and PBX 9502 (95% TATB, 5% Kel-F by weight) to obtain in-situ manganin pressure gauge data and run distances to detonation at various shock pressures. We report the behavior of the HMX-based explosive LX-04 that was damaged mechanically by applying a compressive load of 600 psi for 20,000 cycles, thus creating many small narrow cracks, or by cutting wedge shaped parts that were then loosely reassembled, thus creating a few large cracks. The thermally damaged LX-04 charges were heated to 190 C for long enough for the beta to delta solid - solid phase transition to occur, and then cooled to ambient temperature. Mechanically damaged LX-04 exhibited only slightly increased shock sensitivity, while thermally damaged LX-04 was much more shock sensitive. Similarly, the insensitive explosive PBX 9502 was mechanically damaged using the same two techniques. Since PBX 9502 does not undergo a solid - solid phase transition but does undergo irreversible or 'rachet' growth when thermally cycled, thermal damage to PBX 9502 was induced by this procedure. As for LX-04, the thermally damaged PBX 9502 demonstrated a greater shock sensitivity than mechanically damaged PBX 9502. The Ignition and Growth reactive flow model calculated the increased sensitivities by igniting more damaged LX-04 and PBX 9502 near the shock front based on the measured densities (porosities) of the damaged charges.

  15. Collisionless shocks in space plasmas structure and accelerated particles

    CERN Document Server

    Burgess, David

    2015-01-01

    Shock waves are an important feature of solar system plasmas, from the solar corona out to the edge of the heliosphere. This engaging introduction to collisionless shocks in space plasmas presents a comprehensive review of the physics governing different types of shocks and processes of particle acceleration, from fundamental principles to current research. Motivated by observations of planetary bow shocks, interplanetary shocks and the solar wind termination shock, it emphasises the physical theory underlying these shock waves. Readers will develop an understanding of the complex interplay between particle dynamics and the electric and magnetic fields that explains the observations of in situ spacecraft. Written by renowned experts in the field, this up-to-date text is the ideal companion for both graduate students new to heliospheric physics and researchers in astrophysics who wish to apply the lessons of solar system shocks to different astrophysical environments.

  16. Enteral tranexamic acid attenuates vasopressor resistance and changes in α1-adrenergic receptor expression in hemorrhagic shock.

    Science.gov (United States)

    Santamaria, Marco Henry; Aletti, Federico; Li, Joyce B; Tan, Aaron; Chang, Monica; Leon, Jessica; Schmid-Schönbein, Geert W; Kistler, Erik B

    2017-08-01

    Irreversible hemorrhagic shock is characterized by hyporesponsiveness to vasopressor and fluid therapy. Little is known, however, about the mechanisms that contribute to this phenomenon. Previous studies have shown that decreased intestinal perfusion in hemorrhagic shock leads to proteolytically mediated increases in gut permeability, with subsequent egress of vasoactive substances systemically. Maintenance of blood pressure is achieved in part by α1 receptor modulation, which may be affected by vasoactive factors; we thus hypothesized that decreases in hemodynamic stability and vasopressor response in shock can be prevented by enteral protease inhibition. Rats were exposed to experimental hemorrhagic shock (35 mm Hg mean arterial blood pressure for 2 hours, followed by reperfusion for 2 hours) and challenged with phenylephrine (2 μg/kg) at discrete intervals to measure vasopressor responsiveness. A second group of animals received enteral injections with the protease inhibitor tranexamic acid (TXA) (127 mM) along the small intestine and cecum 1 hour after induction of hemorrhagic shock. Blood pressure response (duration and amplitude) to phenylephrine after reperfusion was significantly attenuated in animals subjected to hemorrhagic shock compared with baseline and control nonshocked animals and was restored to near baseline by enteral TXA. Arteries from shocked animals also displayed decreased α1 receptor density with restoration to baseline after enteral TXA treatment. In vitro, rat shock plasma decreased α1 receptor density in smooth muscle cells, which was also abrogated by enteral TXA treatment. Results from this study demonstrate that experimental hemorrhagic shock leads to decreased response to the α1-selective agonist phenylephrine and decreased α1 receptor density via circulating shock factors. These changes are mitigated by enteral TXA with correspondingly improved hemodynamics. Proteolytic inhibition in the lumen of the small intestine improves

  17. Sticker Shock

    Science.gov (United States)

    Schueler, Beth E.; West, Martin R.

    2016-01-01

    This study examines the role of information in shaping public opinion in the context of support for education spending. While there is broad public support for increasing government funding for public schools, Americans tend to underestimate what is currently spent. We embed a series of experiments in a nationally representative survey administered in 2012 (n = 2,993) to examine whether informing citizens about current levels of education spending alters public opinion about whether funding should increase. Providing information on per-pupil spending in a respondent’s local school district reduces the probability that he or she will express support for increasing spending by 22 percentage points on average. Informing respondents about state-average teacher salaries similarly depresses support for salary increases. These effects are larger among respondents who underestimate per-pupil spending and teacher salaries by a greater amount, consistent with the idea that the observed changes in opinion are driven, at least in part, by informational effects, as opposed to priming alone. PMID:27257308

  18. Prenatal temperature shocks reduce cooperation

    NARCIS (Netherlands)

    Duchoslav, Jan

    2017-01-01

    Climate change has not only led to a sustained rise in mean global temperature over the past decades, but also increased the frequency of extreme weather events. This paper explores the effect of temperature shocks in utero on later-life taste for cooperation. Using historical climate data combined

  19. Alfven shock trains

    International Nuclear Information System (INIS)

    Malkov, M.A.; Kennel, C.F.; Wu, C.C.; Pellat, R.; Shapiro, V.D.

    1991-01-01

    The Cohen--Kulsrud--Burgers equation (CKB) is used to consider the nonlinear evolution of resistive, quasiparallel Alfven waves subject to a long-wavelength, plane-polarized, monochromatic instability. The instability saturates by nonlinear steepening, which proceeds until the periodic waveform develops an interior scale length comparable to the dissipation length; a fast or an intermediate shock then forms. The result is a periodic train of Alfven shocks of one or the other type. For propagation strictly parallel to the magnetic field, there will be two shocks per instability wavelength. Numerical integration of the time-dependent CKB equation shows that an initial, small-amplitude growing wave asymptotes to a stable, periodic stationary wave whose analytic solution specifies how the type of shock embedded in the shock train, and the amplitude and speed of the shock train, depend on the strength and phase of the instability. Waveforms observed upstream of the Earth's bowshock and cometary shocks resemble those calculated here

  20. Changing tides: increasing evidence to embrace a patient classification system.

    Science.gov (United States)

    Malloch, Kathy

    2012-01-01

    The effective use of a patient classification system (PCS) in a way that provides value to all health care organizations has yet to be realized given the challenging developmental pathway of these systems. As the science and technology of workforce management emerges along with evidence to support the relationships between nurse work and patient care needs, it is no longer appropriate to rely on systems that provide aggregated and minimal data to address the need for safer patient care and retention of nurses. Specificity about patient care needs in a valid and reliable PCS is essential on our pathway to improved resource utilization, improved decision making, integration of nurse cognitive and knowledge work, and management of variances from planned resource use. Advancements with technology, the ability to create and monitor equitable nurse-patient assignments, conceptual clarity, evidence, regulatory requirements, and professional role development point to a new receptiveness for PCSs.

  1. GEOMETRICAL OPTIMIZATION OF VEHICLE SHOCK ABSORBERS WITH MR FLUID

    OpenAIRE

    ENGIN, Tahsin; PARLAK, Zekeriya; ŞAHIN, Ismail; ÇALLI, Ismail

    2016-01-01

    Magnetorheological (MR) shock absorber have received remarkable attention in the last decade due to being a potential technology to conduct semi-active control in structures and mechanical systems in order to effectively suppress vibration. To develop performance of MR shock absorbers, optimal design of the dampers should be considered. The present study deals with optimal geometrical modeling of a MR shock absorber. Optimal design of the present shock absorber was carried out by using Taguch...

  2. Effects of Atwood number on shock focusing in shock-cylinder interaction

    Science.gov (United States)

    Ou, Junfeng; Ding, Juchun; Luo, Xisheng; Zhai, Zhigang

    2018-02-01

    The evolution of shock-accelerated heavy-gas cylinder surrounded by the air with different Atwood numbers (A_t=0.28, 0.50, 0.63) is investigated, concentrating on shock focusing and jet formation. Experimentally, a soap film technique is used to generate an ideal two-dimensional discontinuous gas cylinder with a clear surface, which can guarantee the observation of shock wave movements inside the cylinder. Different Atwood numbers are realized by different mixing ratios of SF_6 and air inside the cylinder. A high-speed schlieren system is adopted to capture the shock motions and jet morphology. Numerical simulations are also performed to provide more information. The results indicate that an inward jet is formed for low Atwood numbers, while an outward jet is generated for high Atwood numbers. Different Atwood numbers will lead to the differences in the relative velocities between the incident shock and the refraction shock, which ultimately results in the differences in shock competition near the downstream pole. The morphology and feature of the jet are closely associated with the position and intensity of shock focusing. The pressure and vorticity contours indicate that the jet formation should be attributed to the pressure pulsation caused by shock focusing, and the jet development is ascribed to the vorticity induction. Finally, a time ratio proposed in the previous work for determining the shock-focusing type is verified by experiments.

  3. Generation of narrow energy spread ion beams via collisionless shock waves using ultra-intense 1 um wavelength laser systems

    Science.gov (United States)

    Albert, Felicie; Pak, A.; Kerr, S.; Lemos, N.; Link, A.; Patel, P.; Pollock, B. B.; Haberberger, D.; Froula, D.; Gauthier, M.; Glenzer, S. H.; Longman, A.; Manzoor, L.; Fedosejevs, R.; Tochitsky, S.; Joshi, C.; Fiuza, F.

    2017-10-01

    In this work, we report on electrostatic collisionless shock wave acceleration experiments that produced proton beams with peak energies between 10-17.5 MeV, with narrow energy spreads between Δ E / E of 10-20%, and with a total number of protons in these peaks of 1e7-1e8. These beams of ions were created by driving an electrostatic collisionless shock wave in a tailored near critical density plasma target using the ultra-intense ps duration Titan laser that operates at a wavelength of 1 um. The near critical density target was produced through the ablation of an initially 0.5 um thick Mylar foil with a separate low intensity laser. A narrow energy spread distribution of carbon / oxygen ions with a similar velocity to the accelerated proton distribution, consistent with the reflection and acceleration of ions from an electrostatic field, was also observed. This work was supported by Lawrence Livermore National Laboratory's Laboratory Directed Research and Development program under project 15-LW-095, and the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA2734.

  4. Culture shock

    International Nuclear Information System (INIS)

    Hasell, N.

    1993-01-01

    Morale and performance among staff working for Nuclear Electric, one of the United Kingdom's nuclear power utilities, has risen dramatically from the low levels occurring when the rest of the Central Electricity Generating Board was privatised. This article explains how changed management attitudes, performance-related pay, the pursuit of teamwork and participation have all a role to play in improving business efficiency and increasing output. (UK)

  5. Increased systemic oxidatively generated DNA and RNA damage in schizophrenia

    DEFF Research Database (Denmark)

    Jørgensen, Anders; Brødbæk, Kasper; Fink-Jensen, Anders

    2013-01-01

    such as cardiovascular disease, type 2 diabetes and dementia. We determined the urinary excretion of markers of systemic Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) oxidation, 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-7,8-dihydroguanosine, respectively, in 40 schizophrenia patients and 40 age- and sex...

  6. How to increase work autonomy in workflow management systems?

    NARCIS (Netherlands)

    Vanderfeesten, I.T.P.; Reijers, H.A.

    2006-01-01

    Abstract: Purpose – Current workflow management systems (WfMS's) are often too rigid and lead to "chain production" in the office. The paper proposes a number of "tuning measures" to reconfigure an implemented WfMS in such a way that it is more agreeable to the needs of its users.

  7. Purification and characterization of a chemoattractant from electric shock-induced earthworm secretion, its receptor binding, and signal transduction through the vomeronasal system of garter snakes.

    Science.gov (United States)

    Jiang, X C; Inouchi, J; Wang, D; Halpern, M

    1990-05-25

    Following shocks with low voltage electric current, earthworms, Lumbricus terrestris, secrete a yellow mucus that has alarm properties for conspecifics and chemoattractive properties for garter snakes, Thamnophis sirtalis. A proteinaceous chemoattractant for garter snakes has been isolated and purified to homogeneity from such secretions by means of permeation chromatography and semipreparative nondenaturing polyacrylamide gel electrophoresis. The purified protein is highly attractive to garter snakes; it loses its activity after proteolytic digestion. It is a glycoprotein consisting of a single polypeptide chain with an NH2-terminal alanine. This chemoattractant has a minimum molecular mass of 15.4 kDa calculated from its amino acid and carbohydrate contents and an apparent molecular mass of about 20 kDa as estimated from sodium dodecyl sulfate-polyacrylamide gel electrophoresis. It has a pI of about 4.0, and it binds wheat germ agglutinin but not concanavalin A. This chemoattractant shows a protein to carbohydrate ratio of 2.0 +/- 0.08 (n = 5) and a ratio of total sugar to amino sugar of 1.9 +/- 0.08 (n = 3). The sequence of its NH2-terminal 15 amino acid residues has been determined. Studies were also conducted on the chemosignal transduction through the vomeronasal sensory system of the garter snake. Dot blot analysis showed that the purified chemoattractant bound to snake vomeronasal sensory epithelial membrane fractions. It did not bind to membrane extracts of the nonsensory epithelium of the vomeronasal mushroom body. The chemoattractant also bound specifically to vomeronasal sensory epithelial membrane in a reversible and saturable fashion with Kd and Bmax values of about 0.3 microM and 0.4 nmol/mg of protein, respectively. In electrophysiological studies, the chemoattractant applied to the vomeronasal epithelium caused an increase in firing rate of individual neurons in the accessory olfactory bulb of garter snakes, the projection site for vomeronasal

  8. Passive shock wave/boundary layer control of wing at transonic speeds

    Directory of Open Access Journals (Sweden)

    Ling Zhou

    2017-11-01

    Full Text Available At supercritical conditions a porous strip (or slot strip placed beneath a shock wave can reduce the drag by a weaker lambda shock system, and increase the buffet boundary, even may increase the lift. Passive shock wave/boundary layer control (PSBC for drag reduction was conducted by SC(2-0714 supercritical wing, with emphases on parameter of porous/slot and bump, such as porous distribution, hole diameter, cavity depth, porous direction and so on. A sequential quadratic programming (SQP optimization method coupled with adjoint method was adopted to achieve the optimized shape and position of the bumps. Computational fluid dynamics (CFD, force test and oil test with half model all indicate that PSBC with porous, slot and bump generally reduce the drag by weaker lambda shock at supercritical conditions. According to wind tunnel test results for angle of attack of 2° at Mach number M=0.8, the porous configuration with 6.21% porosity results in a drag reduction of 0.0002 and lift–drag ratio increase of 0.2, the small bump configuration results in a drag reduction of 0.0007 and lift–drag ratio increase of 0.3. Bump normally reduce drag at design point with shock wave position being accurately computed. If bump diverges from the position of shock wave, drag will not be easily reduced.

  9. Soft-sphere simulations of a planar shock interaction with a granular bed

    Science.gov (United States)

    Stewart, Cameron; Balachandar, S.; McGrath, Thomas P.

    2018-03-01

    Here we consider the problem of shock propagation through a layer of spherical particles. A point particle force model is used to capture the shock-induced aerodynamic force acting upon the particles. The discrete element method (DEM) code liggghts is used to implement the shock-induced force as well as to capture the collisional forces within the system. A volume-fraction-dependent drag correction is applied using Voronoi tessellation to calculate the volume of fluid around each individual particle. A statistically stationary frame is chosen so that spatial and temporal averaging can be performed to calculate ensemble-averaged macroscopic quantities, such as the granular temperature. A parametric study is carried out by varying the coefficient of restitution for three sets of multiphase shock conditions. A self-similar profile is obtained for the granular temperature that is dependent on the coefficient of restitution. A traveling wave structure is observed in the particle concentration downstream of the shock and this instability arises from the volume-fraction-dependent drag force. The intensity of the traveling wave increases significantly as inelastic collisions are introduced. Downstream of the shock, the variance in Voronoi volume fraction is shown to have a strong dependence upon the coefficient of restitution, indicating clustering of particles induced by collisional dissipation. Statistics of the Voronoi volume are computed upstream and downstream of the shock and compared to theoretical results for randomly distributed hard spheres.

  10. Subject-specific cardiovascular system model-based identification and diagnosis of septic shock with a minimally invasive data set: animal experiments and proof of concept

    International Nuclear Information System (INIS)

    Geoffrey Chase, J; Starfinger, Christina; Hann, Christopher E; Lambermont, Bernard; Ghuysen, Alexandre; Kolh, Philippe; Dauby, Pierre C; Desaive, Thomas; Shaw, Geoffrey M

    2011-01-01

    A cardiovascular system (CVS) model and parameter identification method have previously been validated for identifying different cardiac and circulatory dysfunctions in simulation and using porcine models of pulmonary embolism, hypovolemia with PEEP titrations and induced endotoxic shock. However, these studies required both left and right heart catheters to collect the data required for subject-specific monitoring and diagnosis—a maximally invasive data set in a critical care setting although it does occur in practice. Hence, use of this model-based diagnostic would require significant additional invasive sensors for some subjects, which is unacceptable in some, if not all, cases. The main goal of this study is to prove the concept of using only measurements from one side of the heart (right) in a 'minimal' data set to identify an effective patient-specific model that can capture key clinical trends in endotoxic shock. This research extends existing methods to a reduced and minimal data set requiring only a single catheter and reducing the risk of infection and other complications—a very common, typical situation in critical care patients, particularly after cardiac surgery. The extended methods and assumptions that found it are developed and presented in a case study for the patient-specific parameter identification of pig-specific parameters in an animal model of induced endotoxic shock. This case study is used to define the impact of this minimal data set on the quality and accuracy of the model application for monitoring, detecting and diagnosing septic shock. Six anesthetized healthy pigs weighing 20–30 kg received a 0.5 mg kg −1 endotoxin infusion over a period of 30 min from T0 to T30. For this research, only right heart measurements were obtained. Errors for the identified model are within 8% when the model is identified from data, re-simulated and then compared to the experimentally measured data, including measurements not used in the

  11. Increased accuracy of cost-estimation using product configuration systems

    DEFF Research Database (Denmark)

    Rasmussen, Jeppe Bredahl; Hvam, Lars; Mortensen, Niels Henrik

    This article describes an approach for utilizing Product Configuration Systems (PCS) for quantifying project costs in project-based companies. It presents a case study demonstrating a method of quantifying costs in a way that makes it possible to configure cost- and time estimates. Piecework costs......, material costs and sub-supplier costs are used as principle cost elements and linked to structural and process elements to facilitate configuration. The cost data are used by the PCS to generate fast and accurate cost-estimates, quotations, time estimates and cost summaries. The described cost...... quantification principles have been used in a Scandinavian SME (Small and Medium-sized Enterprise) since the 90’s, but have since 2011 been adopted to be used in a configuration system. A longitudinal case study was conducted to compare cost and time-estimation accuracy before and after implementation. We...

  12. Increasing flexibility of coal power plant by control system modifications

    Directory of Open Access Journals (Sweden)

    Marušić Ante

    2016-01-01

    Full Text Available Expanding implementation of intermittent renewable energy sources has already started to change the role of thermal power plants in energy systems across Europe. Traditionally base load plants are now forced to operate as peaking plants. A familiar transition in upcoming years is expected in Croatia and coal power plant operators are preparing accordingly. To evaluate cycling capabilities and control system operation for flexible operation of selected 210 MW coal plant, series of tests with different load gradients were performed and results were thoroughly analyzed. Two possible “bottlenecks” are identified, thermal stress in superheater header, and achievable ramping rate considering operational limitations of coal feeders, firing system and evaporator dynamics. Several unexpected readings were observed, usually caused by malfunctioning sensors and equipment, resulting in unexpected oscillations of superheated steam temperature. Based on superheater geometry and experimental data, maximal steam temperature gradient during ramping was evaluated. Since thermal stress was well inside the safety margins, the simulation model of the whole boiler was used to evaluate achievable ramping on electric side.

  13. Dust acoustic shock wave at high dust density

    International Nuclear Information System (INIS)

    Ghosh, Samiran; Sarkar, Susmita; Khan, Manoranjan; Avinash, K.; Gupta, M. R.

    2003-01-01

    Dust acoustic (DA) shock wave at high dust density, i.e., the dust electroacoustic (DEA) or dust Coulomb (DC) shock wave has been investigated incorporating the nonadiabatic dust charge variation. The nonlinear DEA (DC) shock wave is seen to be governed by the Korteweg-de Vries Burger equation, in which the Burger term is proportional to the nonadiabaticity generated dissipation. It is seen that the shock strength decreases but after reaching minimum, it increases as the dust space charge density |q d n d | increases and the shock strength of DA wave is greater than that of DEA (DC) wave. Moreover the DEA (DC) shock width increases appreciably with increase mass m i of the ion component of the dusty plasma but for DA shock wave the effect is weak

  14. Effects of operational shocks on key microbial populations for biogas production in UASB (Upflow Anaerobic Sludge Blanket) reactors

    International Nuclear Information System (INIS)

    Couras, C.S.; Louros, V.L.; Grilo, A.M.; Leitão, J.H.; Capela, M.I.; Arroja, L.M.; Nadais, M.H.

    2014-01-01

    This work compares the overall performance and biogas production of continuous and intermittent UASB (Upflow Anaerobic Sludge Blanket) reactors treating dairy wastewater and subjected to fat, hydraulic and temperature shocks. The systems were monitored for methane production, effluent concentration, volatile fatty acids, and microbial populations of the Eubacteria, Archaea and Syntrophomonadaceae groups. This last microbial group has been reported in literature as being determinant for the degradation of fatty substrates present in the wastewater and subsequent biogas production. Results show that both continuous and intermittent systems supported the applied shocks. However, the intermittent systems exhibited better performance than the continuous systems in biogas production and physical-chemical parameters. Syntrophomonadaceae microbial group was present in the intermittent systems, but was not detected in the biomass from the continuous systems. Hydraulic and temperature shocks, but not the fat shock, caused severe losses in the relative abundance of the Syntrophomonadaceae group in intermittent systems, leading to undetectable levels during the temperature shock. The severity of the effects of the applied shocks on the key microbial group Syntrophomonadaceae, were classified as: fats < hydraulic < temperature. Results from a full-scale anaerobic reactor confirm the effect of intermittent operation on the presence of Syntrophomonadaceae and the effect on reactor performance. - Highlights: • We compared intermittent and continuous UASB reactors upon operational shocks. • Syntrophomonadaceae key microbial group for maximizing biogas was quantified by FISH. • Syntrophomonadaceae is present in intermittent but not in continuous UASB reactors. • Syntrophomonadaceae abundance increases with fat shock in intermittent UASB reactor. • Syntrophomonadaceae abundance decreases with hydraulic or temperature shock

  15. Araloside C Prevents Hypoxia/Reoxygenation-Induced Endoplasmic Reticulum Stress via Increasing Heat Shock Protein 90 in H9c2 Cardiomyocytes

    Directory of Open Access Journals (Sweden)

    Yuyang Du

    2018-04-01

    Full Text Available Araloside C (AsC is a cardioprotective triterpenoid compound that is mainly isolated from Aralia elata. This study aims to determine the effects of AsC on hypoxia-reoxygenation (H/R-induced apoptosis in H9c2 cardiomyocytes and its underlying mechanisms. Results demonstrated that pretreatment with AsC (12.5 μM for 12 h significantly suppressed the H/R injury in H9c2 cardiomyocytes, including improving cell viability, attenuating the LDH leakage and preventing cardiomyocyte apoptosis. AsC also inhibited H/R-induced ER stress by reducing the activation of ER stress pathways (PERK/eIF2α and ATF6, and decreasing the expression of ER stress-related apoptotic proteins (CHOP and caspase-12. Moreover, AsC greatly improved the expression level of HSP90 compared with that in the H/R group. The use of HSP90 inhibitor 17-AAG and HSP90 siRNA blocked the above suppression effect of AsC on ER stress-related apoptosis caused by H/R. Taken together, AsC could reduce H/R-induced apoptosis possibly because it attenuates ER stress-dependent apoptotic pathways by increasing HSP90 expression.

  16. Converging shocks in elastic-plastic solids.

    Science.gov (United States)

    Ortega, A López; Lombardini, M; Hill, D J

    2011-11-01

    We present an approximate description of the behavior of an elastic-plastic material processed by a cylindrically or spherically symmetric converging shock, following Whitham's shock dynamics theory. Originally applied with success to various gas dynamics problems, this theory is presently derived for solid media, in both elastic and plastic regimes. The exact solutions of the shock dynamics equations obtained reproduce well the results obtained by high-resolution numerical simulations. The examined constitutive laws share a compressible neo-Hookean structure for the internal energy e=e(s)(I(1))+e(h)(ρ,ς), where e(s) accounts for shear through the first invariant of the Cauchy-Green tensor, and e(h) represents the hydrostatic contribution as a function of the density ρ and entropy ς. In the strong-shock limit, reached as the shock approaches the axis or origin r=0, we show that compression effects are dominant over shear deformations. For an isothermal constitutive law, i.e., e(h)=e(h)(ρ), with a power-law dependence e(h) is proportional to ρ(α), shock dynamics predicts that for a converging shock located at r=R(t) at time t, the Mach number increases as M is proportional to [log(1/R)](α), independently of the space index s, where s=2 in cylindrical geometry and 3 in spherical geometry. An alternative isothermal constitutive law with p(ρ) of the arctanh type, which enforces a finite density in the strong-shock limit, leads to M is proportional to R(-(s-1)) for strong shocks. A nonisothermal constitutive law, whose hydrostatic part e(h) is that of an ideal gas, is also tested, recovering the strong-shock limit M is proportional to R(-(s-1)/n(γ)) originally derived by Whitham for perfect gases, where γ is inherently related to the maximum compression ratio that the material can reach, (γ+1)/(γ-1). From these strong-shock limits, we also estimate analytically the density, radial velocity, pressure, and sound speed immediately behind the shock. While the

  17. Bulk energy storage increases United States electricity system emissions.

    Science.gov (United States)

    Hittinger, Eric S; Azevedo, Inês M L

    2015-03-03

    Bulk energy storage is generally considered an important contributor for the transition toward a more flexible and sustainable electricity system. Although economically valuable, storage is not fundamentally a "green" technology, leading to reductions in emissions. We model the economic and emissions effects of bulk energy storage providing an energy arbitrage service. We calculate the profits under two scenarios (perfect and imperfect information about future electricity prices), and estimate the effect of bulk storage on net emissions of CO2, SO2, and NOx for 20 eGRID subregions in the United States. We find that net system CO2 emissions resulting from storage operation are nontrivial when compared to the emissions from electricity generation, ranging from 104 to 407 kg/MWh of delivered energy depending on location, storage operation mode, and assumptions regarding carbon intensity. Net NOx emissions range from -0.16 (i.e., producing net savings) to 0.49 kg/MWh, and are generally small when compared to average generation-related emissions. Net SO2 emissions from storage operation range from -0.01 to 1.7 kg/MWh, depending on location and storage operation mode.

  18. Increased longevity of wireless Ad hoc network through fuzzy system

    Directory of Open Access Journals (Sweden)

    Fawzia Abdali Larki

    2014-06-01

    Full Text Available The Ad hoc network is one of the multistep-based self-organizing networks, which are dynamically changing and are taken more into account as the ways of connecting the terminals through the development of wireless communication terminals. We are faced with numerous challenges in designing a wireless network such as the dynamic topology, common and limited bandwidth, and the limited energy. The nodes are moving according to the continuous changes in the topology and the source-to-destination paths are completely broken. Therefore, the repeated route discovery enhances the delay and overload of routing. Thus, it is essential to consider the link stability while designing the path in order to choose the routing protocol. Providing the multiple paths may lead to the better performance than a path. The transmission energy control in the wireless Ad hoc networks is the option for the level of transmission energy in order to transmit each node packet in this system. Therefore, transmission energy control affects the wireless medium interface. Because of choosing the appropriate protocol, the routing operation can be improved and the energy consumption can be controlled properly as well as enhancing the durability and longevity of network. The main objective of this study is to enhance the network longevity. The proposed algorithm in this research considers the combination of 2 parameters including the rate of node energy and number of steps in Fuzzy System applied on AOMDV Protocol, which is a Multipath Routing Protocol. The results of simulation also indicate the improved performance of proposed algorithm (AOMDV-F compared to AODV and AOMDV Protocols in NS2 simulator.

  19. SYSTEM OF INCREASE OF LIBRARY WORKERS INFORMATIVE LITERACY

    Directory of Open Access Journals (Sweden)

    Svitlana M. Ivanova

    2011-02-01

    Full Text Available The article is devoted to the problems of modern information and communication technologies use in professional activity of library workers. The methods of increase of librarian informative literacy are offered. The special course aiming to prepare the skilled specialists who can decide innovative tasks on introduction, management and work with electronic resources is described. The tasks which will help listeners to enter in a theory and practice of electronic resources use in a modern library are decided in the course, such as: to form skills for working in electronic libraries; to teach the methods of modernization of informative librarian services on the base of technologies and resources of electronic libraries, freely Eprints software use.

  20. Shock waves and shock tubes; Proceedings of the Fifteenth International Symposium, Berkeley, CA, July 28-August 2, 1985

    International Nuclear Information System (INIS)

    Bershader, D.; Hanson, R.

    1986-01-01

    A detailed survey is presented of shock tube experiments, theoretical developments, and applications being carried out worldwide. The discussions explore shock tube physics and the related chemical, physical and biological science and technology. Extensive attention is devoted to shock wave phenomena in dusty gases and other multiphase and heterogeneous systems, including chemically reactive mixtures. Consideration is given to techniques for measuring, visualizing and theoretically modeling flowfield, shock wave and rarefaction wave characteristics. Numerical modeling is explored in terms of the application of computational fluid dynamics techniques to describing flowfields in shock tubes. Shock interactions and propagation, in both solids, fluids, gases and mixed media are investigated, along with the behavior of shocks in condensed matter. Finally, chemical reactions that are initiated as the result of passage of a shock wave are discussed, together with methods of controlling the evolution of laminar separated flows at concave corners on advanced reentry vehicles

  1. Surface instabilities in shock loaded granular media

    Science.gov (United States)

    Kandan, K.; Khaderi, S. N.; Wadley, H. N. G.; Deshpande, V. S.

    2017-12-01

    The initiation and growth of instabilities in granular materials loaded by air shock waves are investigated via shock-tube experiments and numerical calculations. Three types of granular media, dry sand, water-saturated sand and a granular solid comprising PTFE spheres were experimentally investigated by air shock loading slugs of these materials in a transparent shock tube. Under all shock pressures considered here, the free-standing dry sand slugs remained stable while the shock loaded surface of the water-saturated sand slug became unstable resulting in mixing of the shocked air and the granular material. By contrast, the PTFE slugs were stable at low pressures but displayed instabilities similar to the water-saturated sand slugs at higher shock pressures. The distal surfaces of the slugs remained stable under all conditions considered here. Eulerian fluid/solid interaction calculations, with the granular material modelled as a Drucker-Prager solid, reproduced the onset of the instabilities as seen in the experiments to a high level of accuracy. These calculations showed that the shock pressures to initiate instabilities increased with increasing material friction and decreasing yield strain. Moreover, the high Atwood number for this problem implied that fluid/solid interaction effects were small, and the initiation of the instability is adequately captured by directly applying a pressure on the slug surface. Lagrangian calculations with the directly applied pressures demonstrated that the instability was caused by spatial pressure gradients created by initial surface perturbations. Surface instabilities are also shown to exist in shock loaded rear-supported granular slugs: these experiments and calculations are used to infer the velocity that free-standing slugs need to acquire to initiate instabilities on their front surfaces. The results presented here, while in an idealised one-dimensional setting, provide physical understanding of the conditions required to

  2. Increasing the productive efficiency of carabaos under smallholder farming systems

    International Nuclear Information System (INIS)

    Momongan, V.G.; Sarabia, A.S.; Roxas, N.P.; Palad, O.A.; Obsioma, A.R.; Nava, Z.M.; Del Barrio, A.N.

    1990-01-01

    There is a need to improve the reproductive efficiency of carabaos to meet the increasing demand for draught power, meat and milk. Under village conditions carabaos appear to have a pregnancy rate of 17.7%; this could be attributed greatly to tethering management, which prevents their natural breeding activities. Moreover, about 32% of the breedable female carabaos are acyclic and only 3.5% are in oestrus at any one time. Carabaos which are either cycling or pregnant have a better body condition than those which are acyclic or non-pregnant. The plasma progesterone level was very low at the time of insemination (<0.5 ng/mL), but gradually increased to above 2.0 ng/mL during the first and second trimesters of pregnancy. Thus, it was possible to diagnose early pregnancy and to confirm oestrus. A positive correlation was observed between plasma and milk progesterone concentrations during the oestrous cycle (r=0.60) and pregnancy (r=0.50). Oestrus synchronization was found to be a useful tool in implementing the cross-breeding of Philippine carabaos with riverine buffaloes through artificial insemination; an average pregnancy rate of about 30% was obtained using frozen semen. The performance of cross-breds showed that the weights at birth were about 36.0 ± 0.9 kg for Phil-Ravi, 33.6 ± 0.9 kg for Phil-Murrah compared with 26.8 ± 0.9 kg for Philippine carabaos. The weights of the three genotypes at 12 months were: 157.0 ± 9.8 kg for Philippine carabaos, 215.4 ± 7.7 kg for Phil-Ravi and 199.8 ± 12.1 kg for Phil-Murrah. At 2 years of age, the carabaos weighed 217.3 ± 18.6 kg, Phil-Ravi 365 ± 23.4 kg and Phil-Murrah 366.3 ± 19.4 kg. The results of this study show that progesterone measurement and oestrus synchronization can be used effectively for cross-breeding carabaos with the frozen semen of river buffaloes. (author). 9 refs, 5 figs, 4 tabs

  3. Corticosteroids in the treatment of dengue shock syndrome

    Directory of Open Access Journals (Sweden)

    Rajapakse S

    2014-05-01

    Full Text Available Senaka Rajapakse,1 Chaturaka Rodrigo,1 Sachith Maduranga,1 Anoja Chamarie Rajapakse21Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka; 2Kings Mill Hospital, Sherwood Forest NHS Foundation Trust, Sutton-in-Ashfield, Nottinghamshire, UKAbstract: Dengue infection causes significant morbidity and mortality in over 100 countries worldwide, and its incidence is on the rise. The pathophysiological basis for the development of severe dengue, characterized by plasma leakage and the “shock syndrome” are poorly understood. No specific treatment or vaccine is available, and careful monitoring and judicious administration of fluids forms the mainstay of management at present. It is postulated that vascular endothelial dysfunction, induced by cytokine and chemical mediators, is an important mechanism of plasma leakage. Although corticosteroids are potent modulators of the immune system, their role in pharmacological doses in modulating the purported immunological effects that take place in severe dengue has been a subject of controversy. The key evidence related to the role of corticosteroids for various manifestations of dengue are reviewed here. In summary, there is currently no high-quality evidence supporting the beneficial effects of corticosteroids for treatment of shock, prevention of serious complications, or increasing platelet counts. Non-randomized trials of corticosteroids given as rescue medication for severe shock have shown possible benefit. Nonetheless, the evidence base is small, and good-quality trials are lacking. We reiterate the need for well-designed and adequately powered randomized controlled trials of corticosteroids for the treatment of dengue shock.Keywords: dengue, dengue shock, shock, corticosteroids, vascular leak, thrombocytopenia

  4. Measuring resilience to energy shocks

    OpenAIRE

    Molyneaux, Lynette; Brown, Colin; Foster, John; Wagner, Liam

    2015-01-01

    Measuring energy security or resilience in energy is, in the main, confined to indicators which are used for comparative purposes or to show trends rather than provide empirical evidence of resilience to unpredicted crises. In this paper, the electricity systems of the individual states within the United States of America are analysed for their response to the 1973-1982 and the 2003-2012 oil price shocks. Empirical evidence is sought for elements which are present in systems that experience r...

  5. Modeling Business Cycle with Financial Shocks Basing on Kaldor-Kalecki Model

    Directory of Open Access Journals (Sweden)

    Zhenghui Li

    2017-04-01

    Full Text Available The effects of financial factors on real business cycle is rising to one of the most popular discussions in the field of macro business cycle theory. The objective of this paper is to discuss the features of business cycle under financial shocks by quantitative technology. More precisely, we introduce financial shocks into the classical Kaldor-Kalecki business cycle model and study dynamics of the model. The shocks include external shock and internal shock, both of which are expressed as noises. The dynamics of the model can help us understand the effects of financial shocks on business cycle and improve our knowledge about financial business cycle. In the case of external shock, if the intensity of shock is less than some threshold value, the economic system behaves randomly periodically. If the intensity of shock is beyond the threshold value, the economic system will converge to a normalcy. In the case of internal shock, if the intensity of shock is less than some threshold value, the economic system behaves periodically as the case without shock. If the intensity of shock exceeds the threshold value, the economic system either behaves periodically or converges to a normalcy. It is uncertain. The case with both two kinds of shocks is more complicated. We find conditions of the intensities of shocks under which the economic system behaves randomly periodically or disorderly, or converges to normalcy. Discussions about the effects of financial shocks on the business cycle are presented.

  6. Shock-wave induced mechanoluminescence: A new technique for studying effects of shock pressure on crystals

    Energy Technology Data Exchange (ETDEWEB)

    Chandra, B.P.; Parganiha, S.; Sonwane, V.D. [School of Studies in Physics and Astrophysics, Pt. Ravishankar Shukla University, Raipur 492010, Chhattisgarh (India); Chandra, V.K. [Department of Electrical and Electronics Engineering, Chhatrapati Shivaji Institute of Technology, Shivaji Nagar, Kolihapuri, Durg 491001, Chhattisgarh (India); Jha, Piyush, E-mail: piyushjha22@rediffmail.com [Department of Applied Physics, Raipur Institute of Technology, Chhatauna, Mandir Hasuad, Raipur 492101, Chhattisgarh (India); Baghel, R.N. [School of Studies in Physics and Astrophysics, Pt. Ravishankar Shukla University, Raipur 492010, Chhattisgarh (India)

    2016-10-15

    The impact of a projectile propelled to velocities in the range of 0.5–2.5 km/s on to a target (X-cut quartz crystal) produces shock waves travelling at velocity of nearly 10 km/s in target, in which intense mechanoluminescence (ML) pulses of microsecond duration are produced, both in compression and post-compression conditions. The piezoelectric field produced due to surface charges of fractured target, causes band bending and subsequently, the free charge carriers are generated in the respective bands and the emission of ML occurs. The ML appears after a delay time t{sub th} whose value decreases with increasing value of the shock pressure. Initially, the ML intensity increases with the shock pressure because of the creation of more surfaces; however, for higher values of the shock pressure, the ML intensity tends to attain a saturation value because of the hardening of the crystals due to the creation of small crystallites in which the creation of new surfaces becomes difficult. The ratio between peak ML intensity in the uncompressed region and the maximum ML intensity in the compressed region decreases with increasing shock pressure because more defects produced at high pressure generate higher barrier for the relaxation of blocked cracks under compression. The expressions derived for characteristics of shock-induced ML are able to explain satisfactorily the experimental results. Shock-wave velocity, shock pressure, transit time, lifetime of electrons in conduction band, etc. can be determined by the shock-induced ML.As such, the shock-induced ML provides a new optical technique for the studies of materials under shock pressure.

  7. TRIGGERING COLLAPSE OF THE PRESOLAR DENSE CLOUD CORE AND INJECTING SHORT-LIVED RADIOISOTOPES WITH A SHOCK WAVE. II. VARIED SHOCK WAVE AND CLOUD CORE PARAMETERS

    Energy Technology Data Exchange (ETDEWEB)

    Boss, Alan P.; Keiser, Sandra A., E-mail: boss@dtm.ciw.edu, E-mail: keiser@dtm.ciw.edu [Department of Terrestrial Magnetism, Carnegie Institution, 5241 Broad Branch Road, NW, Washington, DC 20015-1305 (United States)

    2013-06-10

    A variety of stellar sources have been proposed for the origin of the short-lived radioisotopes that existed at the time of the formation of the earliest solar system solids, including Type II supernovae (SNe), asymptotic giant branch (AGB) and super-AGB stars, and Wolf-Rayet star winds. Our previous adaptive mesh hydrodynamics models with the FLASH2.5 code have shown which combinations of shock wave parameters are able to simultaneously trigger the gravitational collapse of a target dense cloud core and inject significant amounts of shock wave gas and dust, showing that thin SN shocks may be uniquely suited for the task. However, recent meteoritical studies have weakened the case for a direct SN injection to the presolar cloud, motivating us to re-examine a wider range of shock wave and cloud core parameters, including rotation, in order to better estimate the injection efficiencies for a variety of stellar sources. We find that SN shocks remain as the most promising stellar source, though planetary nebulae resulting from AGB star evolution cannot be conclusively ruled out. Wolf-Rayet (WR) star winds, however, are likely to lead to cloud core shredding, rather than to collapse. Injection efficiencies can be increased when the cloud is rotating about an axis aligned with the direction of the shock wave, by as much as a factor of {approx}10. The amount of gas and dust accreted from the post-shock wind can exceed that injected from the shock wave, with implications for the isotopic abundances expected for a SN source.

  8. EXPERIMENTAL STUDY OF SHOCK WAVE DYNAMICS IN MAGNETIZED PLASMAS

    International Nuclear Information System (INIS)

    Podder, Nirmol K.

    2009-01-01

    In this four-year project (including one-year extension), the project director and his research team built a shock-wave-plasma apparatus to study shock wave dynamics in glow discharge plasmas in nitrogen and argon at medium pressure (1-20 Torr), carried out various plasma and shock diagnostics and measurements that lead to increased understanding of the shock wave acceleration phenomena in plasmas. The measurements clearly show that in the steady-state dc glow discharge plasma, at fixed gas pressure the shock wave velocity increases, its amplitude decreases, and the shock wave disperses non-linearly as a function of the plasma current. In the pulsed discharge plasma, at fixed gas pressure the shock wave dispersion width and velocity increase as a function of the delay between the switch-on of the plasma and shock-launch. In the afterglow plasma, at fixed gas pressure the shock wave dispersion width and velocity decrease as a function of the delay between the plasma switch-off and shock-launch. These changes are found to be opposite and reversing towards the room temperature value which is the initial condition for plasma ignition case. The observed shock wave properties in both igniting and afterglow plasmas correlate well with the inferred temperature changes in the two plasmas

  9. Temperature measurements of shock-compressed deuterium

    International Nuclear Information System (INIS)

    Holmes, N.C.; Ross, M.; Nellis, W.J.

    1994-11-01

    The authors measured the temperatures of single and double-shocked D 2 and H 2 up to 85 GPa (0.85 Mbar) and 5,200 K. While single shock temperatures, at pressures to 23 GPa, agree well with previous models, the double shock temperatures are as much as 40% lower than predicted. This is believed to be caused by molecular dissociation, and a new model of the hydrogen EOS at extreme conditions has been developed which correctly predicts their observations. These data and model have important implications for programs which use condensed-phase hydrogen in implosion systems

  10. Effects of Shock and Turbulence Properties on Electron Acceleration

    Science.gov (United States)

    Qin, G.; Kong, F.-J.; Zhang, L.-H.

    2018-06-01

    Using test particle simulations, we study electron acceleration at collisionless shocks with a two-component model turbulent magnetic field with slab component including dissipation range. We investigate the importance of the shock-normal angle θ Bn, magnetic turbulence level {(b/{B}0)}2, and shock thickness on the acceleration efficiency of electrons. It is shown that at perpendicular shocks the electron acceleration efficiency is enhanced with the decrease of {(b/{B}0)}2, and at {(b/{B}0)}2=0.01 the acceleration becomes significant due to a strong drift electric field with long time particles staying near the shock front for shock drift acceleration (SDA). In addition, at parallel shocks the electron acceleration efficiency is increasing with the increase of {(b/{B}0)}2, and at {(b/{B}0)}2=10.0 the acceleration is very strong due to sufficient pitch-angle scattering for first-order Fermi acceleration, as well as due to the large local component of the magnetic field perpendicular to the shock-normal angle for SDA. On the other hand, the high perpendicular shock acceleration with {(b/{B}0)}2=0.01 is stronger than the high parallel shock acceleration with {(b/{B}0)}2=10.0, the reason might be the assumption that SDA is more efficient than first-order Fermi acceleration. Furthermore, for oblique shocks, the acceleration efficiency is small no matter whether the turbulence level is low or high. Moreover, for the effect of shock thickness on electron acceleration at perpendicular shocks, we show that there exists the bendover thickness, L diff,b. The acceleration efficiency does not noticeably change if the shock thickness is much smaller than L diff,b. However, if the shock thickness is much larger than L diff,b, the acceleration efficiency starts to drop abruptly.

  11. Hydraulic shock absorbers

    International Nuclear Information System (INIS)

    Thatcher, G.; Davidson, D. F.

    1984-01-01

    A hydraulic shock absorber of the dash pot kind for use with electrically conducting liquid such as sodium, has magnet means for electro magnetically braking a stream of liquid discharged from the cylinder. The shock absorber finds use in a liquid metal cooled nuclear reactor for arresting control rods

  12. Our Favorite Film Shocks

    DEFF Research Database (Denmark)

    Willerslev, Rane; Suhr, Christian

    2014-01-01

    The modern medium of film has long been hailed for its capacity for producing shocks of an entertaining, thought-provoking, or even politically emancipative nature. But what is a shock, how and when does it occur, how long does it last, and are there particular techniques for producing cinematic...

  13. Climate shocks and conflict

    NARCIS (Netherlands)

    Papaioannou, Kostadis J.

    2016-01-01

    This paper offers a historical micro-level analysis of the impact of climate shocks on the incidence of civil conflict in colonial Nigeria (1912-1945). Primary historical sources on court cases, prisoners and homicides are used to capture conflict. To measure climate shocks we use the deviation

  14. System impact research - increasing public health and health care system performance.

    Science.gov (United States)

    Malmivaara, Antti

    2016-01-01

    Interventions directed to system features of public health and health care should increase health and welfare of patients and population. To build a new framework for studies aiming to assess the impact of public health or health care system, and to consider the role of Randomized Controlled Trials (RCTs) and of Benchmarking Controlled Trials (BCTs). The new concept is partly based on the author's previous paper on the Benchmarking Controlled Trial. The validity and generalizability considerations were based on previous methodological studies on RCTs and BCTs. The new concept System Impact Research (SIR) covers all the studies which aim to assess the impact of the public health system or of the health care system on patients or on population. There are two kinds of studies in System Impact Research: Benchmarking Controlled Trials (observational) and Randomized Controlled Trials (experimental). The term impact covers in particular accessibility, quality, effectiveness, safety, efficiency, and equality. System Impact Research - creating the scientific basis for policy decision making - should be given a high priority in medical, public health and health economic research, and should also be used for improving performance. Leaders at all levels of health and social care can use the evidence from System Impact Research for the benefit of patients and population. Key messages The new concept of SIR is defined as a research field aiming at assessing the impacts on patients and on populations of features of public health and health and social care systems or of interventions trying to change these features. SIR covers all features of public health and health and social care system, and actions upon these features. The term impact refers to all effects caused by the public health and health and social care system or parts of it, with particular emphasis on accessibility, quality, effectiveness, adverse effects, efficiency, and equality of services. SIR creates the

  15. System impact research – increasing public health and health care system performance

    Science.gov (United States)

    Malmivaara, Antti

    2016-01-01

    Abstract Background Interventions directed to system features of public health and health care should increase health and welfare of patients and population. Aims To build a new framework for studies aiming to assess the impact of public health or health care system, and to consider the role of Randomized Controlled Trials (RCTs) and of Benchmarking Controlled Trials (BCTs). Methods The new concept is partly based on the author's previous paper on the Benchmarking Controlled Trial. The validity and generalizability considerations were based on previous methodological studies on RCTs and BCTs. Results The new concept System Impact Research (SIR) covers all the studies which aim to assess the impact of the public health system or of the health care system on patients or on population. There are two kinds of studies in System Impact Research: Benchmarking Controlled Trials (observational) and Randomized Controlled Trials (experimental). The term impact covers in particular accessibility, quality, effectiveness, safety, efficiency, and equality. Conclusions System Impact Research – creating the scientific basis for policy decision making - should be given a high priority in medical, public health and health economic research, and should also be used for improving performance. Leaders at all levels of health and social care can use the evidence from System Impact Research for the benefit of patients and population.Key messagesThe new concept of SIR is defined as a research field aiming at assessing the impacts on patients and on populations of features of public health and health and social care systems or of interventions trying to change these features.SIR covers all features of public health and health and social care system, and actions upon these features. The term impact refers to all effects caused by the public health and health and social care system or parts of it, with particular emphasis on accessibility, quality, effectiveness, adverse effects, efficiency

  16. Increase of COP for heat transformer in water purification systems. Part II - Without increasing heat source temperature

    International Nuclear Information System (INIS)

    Romero, R.J.; Siqueiros, J.; Huicochea, A.

    2007-01-01

    The integration of a water purification system allows a heat transformer to increase the actual coefficient of performance, by the reduction of the amount of heat supplied by unit of heat. A new defined COP called COP WP is proposed for the present system, which considers the fraction of heat recycled. Simulation with proven software compares the performance of the modeling of an absorption heat transformer for water purification (AHTWP) operating with water/lithium bromide, as working fluid-absorbent pair. Plots of enthalpy-based coefficients of performance (COP ET ) and water purification coefficient of performance (COP WP ) are shown against absorber temperature for several thermodynamic operating conditions. The results showed that the proposed (AHTWP) system is capable of increasing the original value of COP ET up to 1.6 times its original value by recycling energy from a water purification system. The proposed COP WP allows increments for COP values from any experimental data for water purification or for any other distillation system integrated to a heat transformer, regardless of actual COP A value or working fluid-absorbent pair

  17. Corticosteroids in the treatment of dengue shock syndrome.

    Science.gov (United States)

    Rajapakse, Senaka; Rodrigo, Chaturaka; Maduranga, Sachith; Rajapakse, Anoja Chamarie

    2014-01-01

    Dengue infection causes significant morbidity and mortality in over 100 countries worldwide, and its incidence is on the rise. The pathophysiological basis for the development of severe dengue, characterized by plasma leakage and the "shock syndrome" are poorly understood. No specific treatment or vaccine is available, and careful monitoring and judicious administration of fluids forms the mainstay of management at present. It is postulated that vascular endothelial dysfunction, induced by cytokine and chemical mediators, is an important mechanism of plasma leakage. Although corticosteroids are potent modulators of the immune system, their role in pharmacological doses in modulating the purported immunological effects that take place in severe dengue has been a subject of controversy. The key evidence related to the role of corticosteroids for various manifestations of dengue are reviewed here. In summary, there is currently no high-quality evidence supporting the beneficial effects of corticosteroids for treatment of shock, prevention of serious complications, or increasing platelet counts. Non-randomized trials of corticosteroids given as rescue medication for severe shock have shown possible benefit. Nonetheless, the evidence base is small, and good-quality trials are lacking. We reiterate the need for well-designed and adequately powered randomized controlled trials of corticosteroids for the treatment of dengue shock.

  18. DebtRank: A Microscopic Foundation for Shock Propagation

    Science.gov (United States)

    Bardoscia, Marco; Battiston, Stefano; Caccioli, Fabio; Caldarelli, Guido

    2015-01-01

    The DebtRank algorithm has been increasingly investigated as a method to estimate the impact of shocks in financial networks, as it overcomes the limitations of the traditional default-cascade approaches. Here we formulate a dynamical “microscopic” theory of instability for financial networks by iterating balance sheet identities of individual banks and by assuming a simple rule for the transfer of shocks from borrowers to lenders. By doing so, we generalise the DebtRank formulation, both providing an interpretation of the effective dynamics in terms of basic accounting principles and preventing the underestimation of losses on certain network topologies. Depending on the structure of the interbank leverage matrix the dynamics is either stable, in which case the asymptotic state can be computed analytically, or unstable, meaning that at least one bank will default. We apply this framework to a dataset of the top listed European banks in the period 2008–2013. We find that network effects can generate an amplification of exogenous shocks of a factor ranging between three (in normal periods) and six (during the crisis) when we stress the system with a 0.5% shock on external (i.e. non-interbank) assets for all banks. PMID:26091013

  19. DebtRank: A Microscopic Foundation for Shock Propagation.

    Directory of Open Access Journals (Sweden)

    Marco Bardoscia

    Full Text Available The DebtRank algorithm has been increasingly investigated as a method to estimate the impact of shocks in financial networks, as it overcomes the limitations of the traditional default-cascade approaches. Here we formulate a dynamical "microscopic" theory of instability for financial networks by iterating balance sheet identities of individual banks and by assuming a simple rule for the transfer of shocks from borrowers to lenders. By doing so, we generalise the DebtRank formulation, both providing an interpretation of the effective dynamics in terms of basic accounting principles and preventing the underestimation of losses on certain network topologies. Depending on the structure of the interbank leverage matrix the dynamics is either stable, in which case the asymptotic state can be computed analytically, or unstable, meaning that at least one bank will default. We apply this framework to a dataset of the top listed European banks in the period 2008-2013. We find that network effects can generate an amplification of exogenous shocks of a factor ranging between three (in normal periods and six (during the crisis when we stress the system with a 0.5% shock on external (i.e. non-interbank assets for all banks.

  20. DebtRank: A Microscopic Foundation for Shock Propagation.

    Science.gov (United States)

    Bardoscia, Marco; Battiston, Stefano; Caccioli, Fabio; Caldarelli, Guido

    2015-01-01

    The DebtRank algorithm has been increasingly investigated as a method to estimate the impact of shocks in financial networks, as it overcomes the limitations of the traditional default-cascade approaches. Here we formulate a dynamical "microscopic" theory of instability for financial networks by iterating balance sheet identities of individual banks and by assuming a simple rule for the transfer of shocks from borrowers to lenders. By doing so, we generalise the DebtRank formulation, both providing an interpretation of the effective dynamics in terms of basic accounting principles and preventing the underestimation of losses on certain network topologies. Depending on the structure of the interbank leverage matrix the dynamics is either stable, in which case the asymptotic state can be computed analytically, or unstable, meaning that at least one bank will default. We apply this framework to a dataset of the top listed European banks in the period 2008-2013. We find that network effects can generate an amplification of exogenous shocks of a factor ranging between three (in normal periods) and six (during the crisis) when we stress the system with a 0.5% shock on external (i.e. non-interbank) assets for all banks.

  1. Pressure resistance of cold-shocked Escherichia coli O157:H7 in ground beef, beef gravy and peptone water.

    Science.gov (United States)

    Baccus-Taylor, G S H; Falloon, O C; Henry, N

    2015-06-01

    (i) To study the effects of cold shock on Escherichia coli O157:H7 cells. (ii) To determine if cold-shocked E. coli O157:H7 cells at stationary and exponential phases are more pressure-resistant than their non-cold-shocked counterparts. (iii) To investigate the baro-protective role of growth media (0·1% peptone water, beef gravy and ground beef). Quantitative estimates of lethality and sublethal injury were made using the differential plating method. There were no significant differences (P > 0·05) in the number of cells killed; cold-shocked or non-cold-shocked. Cells grown in ground beef (stationary and exponential phases) experienced lowest death compared with peptone water and beef gravy. Cold-shock treatment increased the sublethal injury to cells cultured in peptone water (stationary and exponential phases) and ground beef (exponential phase), but decreased the sublethal injury to cells in beef gravy (stationary phase). Cold shock did not confer greater resistance to stationary or exponential phase cells pressurized in peptone water, beef gravy or ground beef. Ground beef had the greatest baro-protective effect. Real food systems should be used in establishing food safety parameters for high-pressure treatments; micro-organisms are less resistant in model food systems, the use of which may underestimate the organisms' resistance. © 2015 The Society for Applied Microbiology.

  2. Energetics of the terrestrial bow shock

    Science.gov (United States)

    Hamrin, Maria; Gunell, Herbert; Norqvist, Patrik

    2017-04-01

    The solar wind is the primary energy source for the magnetospheric energy budget. Energy can enter through the magnetopause both as kinetic energy (plasma entering via e.g. magnetic reconnection and impulsive penetration) and as electromagnetic energy (e.g. by the conversion of solar wind kinetic energy into electromagnetic energy in magnetopause generators). However, energy is extracted from the solar wind already at the bow shock, before it encounters the terrestrial magnetopause. At the bow shock the supersonic solar wind is slowed down and heated, and the region near the bow shock is known to host many complex processes, including the accelerating of particles and the generation of waves. The processes at and near the bow shock can be discussed in terms of energetics: In a generator (load) process kinetic energy is converted to (from) electromagnetic energy. Bow shock regions where the solar wind is decelerated correspond to generators, while regions where particles are energized (accelerated and heated) correspond to loads. Recently, it has been suggested that currents from the bow shock generator should flow across the magnetosheath and connect to the magnetospause current systems [Siebert and Siscoe, 2002; Lopez et al., 2011]. In this study we use data from the Magnetospheric MultiScale (MMS) mission to investigate the energetics of the bow shock and the current closure, and we compare with the MHD simulations of Lopez et al., 2011.

  3. Extracorporeal shock wave lithotripsy: What is new?

    Science.gov (United States)

    Bach, Christian; Karaolides, Theocharis; Buchholz, Noor

    2012-01-01

    Objectives Thirty years after its introduction, extracorporeal shockwave lithotripsy (ESWL) is still first-line treatment for more than half of all urinary tract stones, but machines and treatment strategies have significantly developed over time. In this review, we summarise the latest knowledge about the clinically important aspects of ESWL. Methods We searched PubMed to identify relevant reports and the latest European Association of Urology guidelines, and standard urological textbooks were consulted. Results New technical developments include: Twin-head and tandem-pulse shock-wave generators; wide-focus, low-pressure systems; optimised coupling; and automated location and acoustic tracking systems. Indications have been refined, making possible the identification of patients in whom ESWL treatment is likely to fail. By lowering the shock-wave rate, improving coupling, applying abdominal compression, power ‘ramping’ and postoperative medical expulsion therapy, treatment protocols have been optimised. Conclusions Promising new technical developments are under development, with the potential to increase the stone-free rate after ESWL. For optimal results, the refined indications need to be respected and optimised treatment protocols should be applied. PMID:26558039

  4. Heat shock proteins of higher plants

    International Nuclear Information System (INIS)

    Key, J.L.; Lin, C.Y.; Chen, Y.M.

    1981-01-01

    The pattern of protein synthesis changes rapidly and dramatically when the growth temperture of soybean seedling tissue is increased from 28 0 C (normal) to about 40 0 C (heat shock). The synthesis of normal proteins is greatly decreased and a new set of proteins, heat shock proteins, is induced. The heat shock proteins of soybean consist of 10 new bands on one-dimensional NaDodSO 4 gels; a more complex pattern is observed on two-dimensional gels. when the tissue is returned to 28 0 C after 4 hr at 40 0 C, there is progressive decline in the synthesis of heat shock proteins and reappearance of a normal pattern of synthesis by 3 or 4 hr. In vitro translation of poly(A) + RNAs isolated from tissued grown at 28 and 40 0 C shows that the heat shock proteins are translated from a ndw set of mRNAs induced at 40 0 C; furthermore, the abundant class mRNAs for many of the normal proteins persist even though they are translated weakly (or not at all) in vivo at 40 or 42.5 0 C. The heat shock response in soybean appears similar to the much-studied heat shock phenomenon in Drosophila

  5. Impaired Fracture Healing after Hemorrhagic Shock

    Directory of Open Access Journals (Sweden)

    Philipp Lichte

    2015-01-01

    Full Text Available Impaired fracture healing can occur in severely injured patients with hemorrhagic shock due to decreased soft tissue perfusion after trauma. We investigated the effects of fracture healing in a standardized pressure controlled hemorrhagic shock model in mice, to test the hypothesis that bleeding is relevant in the bone healing response. Male C57/BL6 mice were subjected to a closed femoral shaft fracture stabilized by intramedullary nailing. One group was additionally subjected to pressure controlled hemorrhagic shock (HS, mean arterial pressure (MAP of 35 mmHg for 90 minutes. Serum cytokines (IL-6, KC, MCP-1, and TNF-α were analyzed 6 hours after shock. Fracture healing was assessed 21 days after fracture. Hemorrhagic shock is associated with a significant increase in serum inflammatory cytokines in the early phase. Histologic analysis demonstrated a significantly decreased number of osteoclasts, a decrease in bone quality, and more cartilage islands after hemorrhagic shock. μCT analysis showed a trend towards decreased bone tissue mineral density in the HS group. Mechanical testing revealed no difference in tensile failure. Our results suggest a delay in fracture healing after hemorrhagic shock. This may be due to significantly diminished osteoclast recruitment. The exact mechanisms should be studied further, particularly during earlier stages of fracture healing.

  6. Self-similar dynamic converging shocks - I. An isothermal gas sphere with self-gravity

    Science.gov (United States)

    Lou, Yu-Qing; Shi, Chun-Hui

    2014-07-01

    We explore novel self-similar dynamic evolution of converging spherical shocks in a self-gravitating isothermal gas under conceivable astrophysical situations. The construction of such converging shocks involves a time-reversal operation on feasible flow profiles in self-similar expansion with a proper care for the increasing direction of the specific entropy. Pioneered by Guderley since 1942 but without self-gravity so far, self-similar converging shocks are important for implosion processes in aerodynamics, combustion, and inertial fusion. Self-gravity necessarily plays a key role for grossly spherical structures in very broad contexts of astrophysics and cosmology, such as planets, stars, molecular clouds (cores), compact objects, planetary nebulae, supernovae, gamma-ray bursts, supernova remnants, globular clusters, galactic bulges, elliptical galaxies, clusters of galaxies as well as relatively hollow cavity or bubble structures on diverse spatial and temporal scales. Large-scale dynamic flows associated with such quasi-spherical systems (including collapses, accretions, fall-backs, winds and outflows, explosions, etc.) in their initiation, formation, and evolution are likely encounter converging spherical shocks at times. Our formalism lays an important theoretical basis for pertinent astrophysical and cosmological applications of various converging shock solutions and for developing and calibrating numerical codes. As examples, we describe converging shock triggered star formation, supernova explosions, and void collapses.

  7. Crack propagation behavior of TiN coatings by laser thermal shock experiments

    International Nuclear Information System (INIS)

    Choi, Youngkue; Jeon, Seol; Jeon, Min-seok; Shin, Hyun-Gyoo; Chun, Ho Hwan; Lee, Youn-seoung; Lee, Heesoo

    2012-01-01

    Highlights: ► The crack propagation behavior of TiN coating after laser thermal shock experiment was observed by using FIB and TEM. ► Intercolumnar cracks between TiN columnar grains were predominant cracking mode after laser thermal shock. ► Cracks were propagated from the coating surface to the substrate at low laser pulse energy and cracks were originated at coating-substrate interface at high laser pulse energy. ► The cracks from the interface spread out transversely through the weak region of the columnar grains by repetitive laser shock. - Abstract: The crack propagation behavior of TiN coatings, deposited onto 304 stainless steel substrates by arc ion plating technique, related to a laser thermal shock experiment has been investigated using focused ion beam (FIB) and transmission electron microscopy (TEM). The ablated regions of TiN coatings by laser ablation system have been investigated under various conditions of pulse energies and number of laser pulses. The intercolumnar cracks were predominant cracking mode following laser thermal shock tests and the cracks initiated at coating surface and propagated in a direction perpendicular to the substrate under low loads conditions. Over and above those cracks, the cracks originated from coating-substrate interface began to appear with increasing laser pulse energy. The cracks from the interface also spread out transversely through the weak region of the columnar grains by repetitive laser shock.

  8. Micro-Raman spectroscopy of plagioclase and maskelynite in Martian meteorites: Evidence of progressive shock metamorphism

    OpenAIRE

    Fritz,Jorg; Greshake,Ansgar; Stoffler,Dieter

    2005-01-01

    We present the first systematic Micro-Raman spectroscopic investigation of plagioclase of different degree of shock metamorphism in Martian meteorites. The equilibrium shock pressure of all plagioclase phases of seventeen unpaired Martian meteorites was determined by measuring the shock-induced reduction of the refractive index. Systematic variations in the recorded Raman spectra of the plagioclase phases correlate with increasing shock pressure. In general, the shock induced deformation of t...

  9. Ion Thermalization and Electron Heating across Quasi-Perpendicular Shocks Observed by the MMS Mission

    Science.gov (United States)

    Chen, L. J.; Wilson, L. B., III; Wang, S.; Bessho, N.; Figueroa-Vinas, A.; Lai, H.; Russell, C. T.; Schwartz, S. J.; Hesse, M.; Moore, T. E.; Burch, J.; Gershman, D. J.; Giles, B. L.; Torbert, R. B.; Ergun, R.; Dorelli, J.; Strangeway, R. J.; Paterson, W. R.; Lavraud, B.; Khotyaintsev, Y. V.

    2017-12-01

    Collisionless shocks often involve intense plasma heating in space and astrophysical systems. Despite decades of research, a number of key questions concerning electron and ion heating across collisionless shocks remain unanswered. We `image' 20 supercritical quasi-perpendicular bow shocks encountered by the Magnetospheric Multiscale (MMS) spacecraft with electron and ion distribution functions to address how ions are thermalized and how electrons are heated. The continuous burst measurements of 3D plasma distribution functions from MMS reveal that the primary thermalization phase of ions occurs concurrently with the main temperature increase of electrons as well as large-amplitude wave fluctuations. Approaching the shock from upstream, the ion temperature (Ti) increases due to the reflected ions joining the incoming solar wind population, as recognized by prior studies, and the increase of Ti precedes that of the electrons. Thermalization in the form of merging between the decelerated solar wind ions and the reflected component often results in a decrease in Ti. In most cases, the Ti decrease is followed by a gradual increase further downstream. Anisotropic, energy-dependent, and/or nongyrotropic electron energization are observed in association with large electric field fluctuations in the main electron temperature (Te) gradient, motivating a renewed scrutiny of the effects from the electrostatic cross-shock potential and wave fluctuations on electron heating. Particle-in-cell (PIC) simulations are carried out to assist interpretations of the MMS observations. We assess the roles of instabilities and the cross-shock potential in thermalizing ions and heating electrons based on the MMS measurements and PIC simulation results. Challenges will be posted for future computational studies and laboratory experiments on collisionless shocks.

  10. The thickness of the interplanetary collisionless shock waves

    International Nuclear Information System (INIS)

    Pinter, S.

    1980-05-01

    The thicknesses of magnetic structures of the interplanetary shock waves related to the upstream solar wind plasma parameters are studied. From this study the following results have been obtained: the measured shock thickness increases for decreasing upstream proton number density and decreases for increasing proton flux energy. The shock thickness strongly depends on the ion plasma β, i.e. for higher values of the β the thickness decreases. (author)

  11. Pediatric Toxic Shock Syndrome

    Directory of Open Access Journals (Sweden)

    Jennifer Yee

    2017-09-01

    Full Text Available Audience: This scenario was developed to educate emergency medicine residents on the diagnosis and management of a pediatric patient with toxic shock syndrome. The case is also appropriate for teaching of medical students and advanced practice providers, as well as a review of the principles of crisis resource management, teamwork, and communication. Introduction: Toxic shock syndrome is a low-frequency, high-acuity scenario requiring timely identification and aggressive management. If patients suffering from this condition are managed incorrectly, they may progress into multi-organ dysfunction and potentially death. Toxic shock syndrome has been associated with Streptococcus and Staphylococcus aureus (Staph. Approximately half of Staph cases are associated with menstruation, which was first described in the 1970s-1980s and was associated with the use of absorbent tampons.1 Group A Streptococcus may cause complications such as necrotizing fasciitis and gangrenous myositis.2 Pediatric patients may present critically ill from toxic shock syndrome. Providers need to perform a thorough history and physical exam to discern the source of infection. Management requires aggressive care with antibiotics and IV fluids. Objectives: By the end of this simulation session, the learner will be able to: 1 Recognize toxic shock syndrome. 2 Review the importance of a thorough physical exam. 3 Discuss management of toxic shock syndrome, including supportive care and the difference in antibiotic choices for streptococcal and staphylococcal toxic shock syndrome. 4 Appropriately disposition a patient suffering from toxic shock syndrome. 5 Communicate effectively with team members and nursing staff during a resuscitation of a critically ill patient. Method: This session was conducted using high-fidelity simulation, followed by a debriefing session and lecture on toxic shock syndrome.

  12. Initiation of lambda DNA replication. The Escherichia coli small heat shock proteins, DnaJ and GrpE, increase DnaK's affinity for the lambda P protein.

    Science.gov (United States)

    Osipiuk, J; Georgopoulos, C; Zylicz, M

    1993-03-05

    It is known that the initiation of bacteriophage lambda replication requires the orderly assembly of the lambda O.lambda P.DnaB helicase protein preprimosomal complex at the ori lambda DNA site. The DnaK, DnaJ, and GrpE heat shock proteins act together to destabilize the lambda P.DnaB complex, thus freeing DnaB and allowing it to unwind lambda DNA near the ori lambda site. The first step of this disassembly reaction is the binding of DnaK to the lambda P protein. In this report, we examined the influence of the DnaJ and GrpE proteins on the stability of the lambda P.DnaK complex. We present evidence for the existence of the following protein-protein complexes: lambda P.DnaK, lambda P.DnaJ, DnaJ.DnaK, DnaK.GrpE, and lambda P.DnaK.GrpE. Our results suggest that the presence of GrpE alone destabilizes the lambda P.DnaK complex, whereas the presence of DnaJ alone stabilizes the lambda P.DnaK complex. Using immunoprecipitation, we show that in the presence of GrpE, DnaK exhibits a higher affinity for the lambda P.DnaJ complex than it does alone. Using cross-linking with glutaraldehyde, we show that oligomeric forms of DnaK exhibit a higher affinity for lambda P than monomeric DnaK. However, in the presence of GrpE, monomeric DnaK can efficiently bind lambda P protein. These findings help explain our previous results, namely that in the GrpE-dependent lambda DNA replication system, the DnaK protein requirement can be reduced up to 10-fold.

  13. Effort to increase an engine performance using electrical ignition system for motor vehicle

    Directory of Open Access Journals (Sweden)

    I Wayan Bandem Adnyana

    2012-11-01

    Full Text Available Increasing engine performances using electrical ignition system on motor vehicle. In accordance with the development oftechnology, improvisation of automotive is created in order to increase the performance of engine. The method to increase thisperformance has been done by modify the ignition system, where the conventional method of ignition system which uses contactbreaker substituted by using capacitor. The improvisation of ignition system has been tested by increasing the speed and load onstationary condition. Results show that the improvisation of ignition system by using capacitor increases the effective power andreduce the specific fuel consumption of engine and reduce the gas emission of CO.

  14. Shocks near Jamming

    Science.gov (United States)

    Gómez, Leopoldo R.; Turner, Ari M.; van Hecke, Martin; Vitelli, Vincenzo

    2012-02-01

    Nonlinear sound is an extreme phenomenon typically observed in solids after violent explosions. But granular media are different. Right when they jam, these fragile and disordered solids exhibit a vanishing rigidity and sound speed, so that even tiny mechanical perturbations form supersonic shocks. Here, we perform simulations in which two-dimensional jammed granular packings are dynamically compressed and demonstrate that the elementary excitations are strongly nonlinear shocks, rather than ordinary phonons. We capture the full dependence of the shock speed on pressure and impact intensity by a surprisingly simple analytical model.

  15. Mechanical shock absorber

    International Nuclear Information System (INIS)

    Vrillon, Bernard.

    1973-01-01

    The mechanical shock absorber described is made of a constant thickness plate pierced with circular holes regularly distributed in such a manner that for all the directions along which the strain is applied during the shock, the same section of the substance forming the plate is achieved. The shock absorber is made in a metal standing up to extensive deformation before breaking, selected from a group comprising mild steels and austenitic stainless steels. This apparatus is used for handling pots of fast neutron reactor fuel elements [fr

  16. Shock formation of HCO+

    International Nuclear Information System (INIS)

    Elitzur, M.

    1983-01-01

    It is shown that shocks propagating in dense molecular regions will lead to a decrease in HCO + relative abundance, in agreement with previous results by Iglesias and Silk. The shock enhancement of HCO + detected in the supernova remnant IC 443 by Dickenson et al. is due to enhanced ionization in the shocked material. This is the result of the material penetrating the remnant cavity where it becomes exposed to the trapped cosmic rays. A similar enhancement appears to have been detected by Wootten in W28 and is explained by the same model

  17. Effects of Alfvénic Drift on Diffusive Shock Acceleration at Weak Cluster Shocks

    Science.gov (United States)

    Kang, Hyesung; Ryu, Dongsu

    2018-03-01

    Non-detection of γ-ray emission from galaxy clusters has challenged diffusive shock acceleration (DSA) of cosmic-ray (CR) protons at weak collisionless shocks that are expected to form in the intracluster medium. As an effort to address this problem, we here explore possible roles of Alfvén waves self-excited via resonant streaming instability during the CR acceleration at parallel shocks. The mean drift of Alfvén waves may either increase or decrease the scattering center compression ratio, depending on the postshock cross-helicity, leading to either flatter or steeper CR spectra. We first examine such effects at planar shocks, based on the transport of Alfvén waves in the small amplitude limit. For the shock parameters relevant to cluster shocks, Alfvénic drift flattens the CR spectrum slightly, resulting in a small increase of the CR acceleration efficiency, η. We then consider two additional, physically motivated cases: (1) postshock waves are isotropized via MHD and plasma processes across the shock transition, and (2) postshock waves contain only forward waves propagating along with the flow due to a possible gradient of CR pressure behind the shock. In these cases, Alfvénic drift could reduce η by as much as a factor of five for weak cluster shocks. For the canonical parameters adopted here, we suggest η ∼ 10‑4–10‑2 for shocks with sonic Mach number M s ≈ 2–3. The possible reduction of η may help ease the tension between non-detection of γ-rays from galaxy clusters and DSA predictions.

  18. Enhancements of energetic particles near the heliospheric termination shock.

    Science.gov (United States)

    McDonald, Frank B; Stone, Edward C; Cummings, Alan C; Heikkila, Bryant; Lal, Nand; Webber, William R

    2003-11-06

    The spacecraft Voyager 1 is at a distance greater than 85 au from the Sun, in the vicinity of the termination shock that marks the abrupt slowing of the supersonic solar wind and the beginning of the extended and unexplored distant heliosphere. This shock is expected to accelerate 'anomalous cosmic rays', as well as to re-accelerate Galactic cosmic rays and low-energy particles from the inner Solar System. Here we report a significant increase in the numbers of energetic ions and electrons that persisted for seven months beginning in mid-2002. This increase differs from any previously observed in that there was a simultaneous increase in Galactic cosmic ray ions and electrons, anomalous cosmic rays and low-energy ions. The low-intensity level and spectral energy distribution of the anomalous cosmic rays, however, indicates that Voyager 1 still has not reached the termination shock. Rather, the observed increase is an expected precursor event. We argue that the radial anisotropy of the cosmic rays is expected to be small in the foreshock region, as is observed.

  19. Tribology Aspect of Rubber Shock Absorbers Development

    Directory of Open Access Journals (Sweden)

    M. Banić

    2013-09-01

    Full Text Available Rubber is a very flexible material with many desirable properties Which enable its broad use in engineering practice. Rubber or rubber-metal springs are widely used as anti-vibration or anti-shock components in technical systems. Rubber-metal springs are usually realized as a bonded assembly, however especially in shock absorbers, it is possible to realize free contacts between rubber and metal parts. In previous research it authors was observed that friction between rubber and metal in such case have a significant influence on the damping characteristics of shock absorber. This paper analyzes the development process of rubber or rubber-metal shock absorbers realized free contacts between the constitutive parts, starting from the design, construction, testing and operation, with special emphasis on the development of rubber-metal springs for the buffing and draw gear of railway vehicles.

  20. Critical point anomalies include expansion shock waves

    Energy Technology Data Exchange (ETDEWEB)

    Nannan, N. R., E-mail: ryan.nannan@uvs.edu [Mechanical Engineering Discipline, Anton de Kom University of Suriname, Leysweg 86, PO Box 9212, Paramaribo, Suriname and Process and Energy Department, Delft University of Technology, Leeghwaterstraat 44, 2628 CA Delft (Netherlands); Guardone, A., E-mail: alberto.guardone@polimi.it [Department of Aerospace Science and Technology, Politecnico di Milano, Via La Masa 34, 20156 Milano (Italy); Colonna, P., E-mail: p.colonna@tudelft.nl [Propulsion and Power, Delft University of Technology, Kluyverweg 1, 2629 HS Delft (Netherlands)

    2014-02-15

    From first-principle fluid dynamics, complemented by a rigorous state equation accounting for critical anomalies, we discovered that expansion shock waves may occur in the vicinity of the liquid-vapor critical point in the two-phase region. Due to universality of near-critical thermodynamics, the result is valid for any common pure fluid in which molecular interactions are only short-range, namely, for so-called 3-dimensional Ising-like systems, and under the assumption of thermodynamic equilibrium. In addition to rarefaction shock waves, diverse non-classical effects are admissible, including composite compressive shock-fan-shock waves, due to the change of sign of the fundamental derivative of gasdynamics.

  1. Shock Isolation Elements Testing for High Input Loadings. Volume II. Foam Shock Isolation Elements.

    Science.gov (United States)

    SHOCK ABSORBERS ), (*GUIDED MISSILE SILOS, SHOCK ABSORBERS ), (*EXPANDED PLASTICS, (*SHOCK(MECHANICS), REDUCTION), TEST METHODS, SHOCK WAVES, STRAIN(MECHANICS), LOADS(FORCES), MATHEMATICAL MODELS, NUCLEAR EXPLOSIONS, HARDENING.

  2. Structure of intermediate shocks and slow shocks in a magnetized plasma with heat conduction

    International Nuclear Information System (INIS)

    Tsai, C.L.; Wu, B.H.; Lee, L.C.

    2005-01-01

    The structure of slow shocks and intermediate shocks in the presence of a heat conduction parallel to the local magnetic field is simulated from the set of magnetohydrodynamic equations. This study is an extension of an earlier work [C. L. Tsai, R. H. Tsai, B. H. Wu, and L. C. Lee, Phys. Plasmas 9, 1185 (2002)], in which the effects of heat conduction are examined for the case that the tangential magnetic fields on the two side of initial current sheet are exactly antiparallel (B y =0). For the B y =0 case, a pair of slow shocks is formed as the result of evolution of the initial current sheet, and each slow shock consists of two parts: the isothermal main shock and the foreshock. In the present paper, cases with B y ≠0 are also considered, in which the evolution process leads to the presence of an additional pair of time-dependent intermediate shocks (TDISs). Across the main shock of the slow shock, jumps in plasma density, velocity, and magnetic field are significant, but the temperature is continuous. The plasma density downstream of the main shock decreases with time, while the downstream temperature increases with time, keeping the downstream pressure constant. The foreshock is featured by a smooth temperature variation and is formed due to the heat flow from downstream to upstream region. In contrast to the earlier study, the foreshock is found to reach a steady state with a constant width in the slow shock frame. In cases with B y ≠0, the plasma density and pressure increase and the magnetic field decreases across TDIS. The TDIS initially can be embedded in the slow shock's foreshock structure, and then moves out of the foreshock region. With an increasing B y , the propagation speed of foreshock leading edge tends to decrease and the foreshock reaches its steady state at an earlier time. Both the pressure and temperature downstreams of the main shock decrease with increasing B y . The results can be applied to the shock heating in the solar corona and

  3. Shock wave propagation in neutral and ionized gases

    International Nuclear Information System (INIS)

    Podder, N. K.; Wilson IV, R. B.; Bletzinger, P.

    2008-01-01

    Preliminary measurements on a recently built shock tube are presented. Planar shock waves are excited by the spark discharge of a capacitor, and launched into the neutral argon or nitrogen gas as well as its ionized glow discharge in the pressure region 1-17 Torr. For the shock wave propagation in the neutral argon at fixed capacitor charging voltage, the shock wave velocity is found to increase nonlinearly at the lower pressures, reach a maximum at an intermediate pressure, and then decrease almost linearly at the higher pressures, whereas the shock wave strength continues to increase at a nonlinear rate over the entire range of pressure. However, at fixed gas pressure the shock wave velocity increases almost monotonically as the capacitor charging voltage is increased. For the shock wave propagation in the ionized argon glow, the shock wave is found to be most influenced by the glow discharge plasma current. As the plasma current is increased, both the shock wave propagation velocity and the dispersion width are observed to increase nonlinearly

  4. A novel regenerative shock absorber with a speed doubling mechanism and its Monte Carlo simulation

    Science.gov (United States)

    Zhang, Ran; Wang, Xu; Liu, Zhenwei

    2018-03-01

    A novel regenerative shock absorber has been designed and fabricated. The novelty of the presented work is the application of the double speed regenerative shock absorber that utilizes the rack and pinion mechanism to increase the magnet speed with respect to the coils for higher power output. The simulation models with parameters identified from finite element analysis and the experiments are developed. The proposed regenerative shock absorber is compared with the regenerative shock absorber without the rack and pinion mechanism, when they are integrated into the same quarter vehicle suspension system. The sinusoidal wave road profile displacement excitation and the random road profile displacement excitation with peak amplitude of 0.035 m are applied as the inputs in the frequency range of 0-25 Hz. It is found that with the sinusoidal and random road profile displacement input, the proposed innovative design can increase the output power by 4 times comparing to the baseline design. The proposed double speed regenerative shock absorber also presents to be more sensitive to the road profile irregularity than the single speed regenerative shock absorber as suggested by Monte Carlo simulation. Lastly the coil mass and amplification factor are studied for sensitivity analysis and performance optimization, which provides a general design method of the regenerative shock absorbers. It shows that for the system power output, the proposed design becomes more sensitive to either the coil mass or amplification factor depending on the amount of the coil mass. With the specifically selected combination of the coil mass and amplification factor, the optimized energy harvesting performance can be achieved.

  5. Gibberellic Acid-Induced Aleurone Layers Responding to Heat Shock or Tunicamycin Provide Insight into the N-Glycoproteome, Protein Secretion, and Endoplasmic Reticulum Stress

    DEFF Research Database (Denmark)

    Barba Espin, Gregorio; Dedvisitsakul, Plaipol; Hägglund, Per

    2014-01-01

    respond to gibberellic acid by secreting an array of proteins and provide a unique system for the analysis of plant protein secretion. Perturbation of protein secretion in gibberellic acid-induced aleurone layers by two independent mechanisms, heat shock and tunicamycin treatment, demonstrated overlapping...... and secretion, such as calreticulin, protein disulfide isomerase, proteasome subunits, and isopentenyl diphosphate isomerase. Sixteen heat shock proteins in 29 spots showed diverse responses to the treatments, with only a minority increasing in response to heat shock. The majority, all of which were small heat...... shock proteins, decreased in heat-shocked aleurone layers. Additionally, glycopeptide enrichment and N-glycosylation analysis identified 73 glycosylation sites in 65 aleurone layer proteins, with 53 of the glycoproteins found in extracellular fractions and 36 found in intracellular fractions...

  6. Practical method for assessing pressure shock hazards in pipeline systems of the process industry; Praxisorientierte Vorgehensweise zur Beurteilung der Druckstossgefahren in Rohrleitungssystemen der Prozessindustrie

    Energy Technology Data Exchange (ETDEWEB)

    Thiemeier, T.; Westphal, F. [Siemens AG Automation and Drives, Prozess Sicherheit, Frankfurt am Main (Germany); Schaefer, J. [Sanofi-Aventis Deutschland GmbH, USB Sicherheit, Frankfurt am Main (Germany)

    2006-11-15

    In industrial applications where long large-diameter pipelines are required, the danger of pressure shocks and cavitation shocks is well known and is taken into account in projecting. Transient flow phenomena, however, tend to be neglected even though damage and leakages are caused by the same mechanisms also in chemical engineering processes. The contribution describes a staged procedure that makes it possible to assess the potential hazards resulting from pressure shocks in process engineering without requiring too detailed an analysis of uncritical cases. (orig.)

  7. Mechanical Properties of Shock-Damaged Rocks

    Science.gov (United States)

    He, Hongliang; Ahrens, T. J.

    1994-01-01

    Stress-strain tests were performed both on shock-damaged gabbro and limestone. The effective Young's modulus decreases with increasing initial damage parameter value, and an apparent work-softening process occurs prior to failure. To further characterize shock-induced microcracks, the longitudinal elastic wave velocity behavior of shock-damaged gabbro in the direction of compression up to failure was measured using an acoustic transmission technique under uniaxial loading. A dramatic increase in velocity was observed for the static compressive stress range of 0-50 MPa. Above that stress range, the velocity behavior of lightly damaged (D(sub 0) less than 0.1) gabbro is almost equal to unshocked gabbro. The failure strength of heavily-damaged (D(sub 0) greater than 0.1) gabbro is approx. 100-150 MPa, much lower than that of lightly damaged and unshocked gabbros (approx. 230-260 MPa). Following Nur's theory, the crack shape distribution was analyzed. The shock-induced cracks in gabbro appear to be largely thin penny-shaped cracks with c/a values below 5 x 10(exp -4). Moreover, the applicability of Ashby and Sammis's theory relating failure strength and damage parameter of shock-damaged rocks was examined and was found to yield a good estimate of the relation of shock-induced deficit in elastic modulus with the deficit in compressive strength.

  8. Counseling For Future Shock

    Science.gov (United States)

    Morgan, Lewis B.

    1974-01-01

    In this article the author looks at some of the searing prophecies made by Alvin Toffler in his book Future Shock and relates them to the world of the professional counselor and the clientele the counselor attempts to serve. (Author)

  9. Unlimited Relativistic Shock Surfing Acceleration

    International Nuclear Information System (INIS)

    Ucer, D.; Shapiro, V. D.

    2001-01-01

    Nonrelativistic shock surfing acceleration at quasiperpendicular shocks is usually considered to be a preacceleration mechanism for slow pickup ions to initiate diffusive shock acceleration. In shock surfing, the particle accelerates along the shock front under the action of the convective electric field of the plasma flow. However, the particle also gains kinetic energy normal to the shock and eventually escapes downstream. We consider the case when ions are accelerated to relativistic velocities. In this case, the ions are likely to be trapped for infinitely long times, because the energy of bounce oscillations tends to decrease during acceleration. This suggests the possibility of unlimited acceleration by shock surfing

  10. Is shock index associated with outcome in children with sepsis/septic shock?*.

    Science.gov (United States)

    Yasaka, Yuki; Khemani, Robinder G; Markovitz, Barry P

    2013-10-01

    To investigate the association between PICU shock index (the ratio of heart rate to systolic blood pressure) and PICU mortality in children with sepsis/septic shock. To explore cutoff values for shock index for ICU mortality, how change in shock index over the first 6 hours of ICU admission is associated with outcome, and how the use of vasoactive therapy may affect shock index and its association with outcome. Retrospective cohort. Single-center tertiary PICU. Five hundred forty-four children with the diagnosis of sepsis/septic shock. None. From January 2003 to December 2009, 544 children met International Pediatric Sepsis Consensus Conference of 2005 criteria for sepsis/septic shock. Overall mortality was 23.7%. Among all patients, hourly shock index was associated with mortality: odds ratio of ICU mortality at 0 hour, 1.08, 95% CI (1.04-1.12); odds ratio at 1 hour, 1.09 (1.04-1.13); odds ratio at 2 hours, 1.09 (1.05-1.13); and odds ratio at 6 hours, 1.11 (1.06-1.15). When stratified by age, early shock index was associated with mortality only in children 1-3 and more than or equal to 12 years old. Area under the receiver operating characteristic curve in age 1-3 and more than or equal to 12 years old for shock index at admission was 0.69 (95% CI, 0.58-0.80) and 0.62 (95% CI, 0.52-0.72) respectively, indicating a fair predictive marker. Although higher shock index was associated with increased risk of mortality, there was no particular cutoff value with adequate positive or negative likelihood ratios to identify mortality in any age group of children. The improvement of shock index in the first 6 hours of ICU admission was not associated with outcome when analyzed in all patients. However, among patients whose shock index were above the 50th percentile at ICU admission for each age group, improvement of shock index was associated with lower ICU mortality in children between 1-3 and more than or equal to 12 years old (p = 0.02 and p = 0.03, respectively). When

  11. Technology shocks matter

    OpenAIRE

    Jonas D. M. Fisher

    2002-01-01

    This paper uses the neoclassical growth model to identify the effects of technological change on the US business cycle. In the model there are two sources of technological change: neutral, which effects the production of all goods homogeneously, and investment-specific. Investment-specific shocks are the unique source of the secular trend in the real price of investment goods, while shocks to both kinds of technology are the only factors which affect labor productivity in the long run. Consis...

  12. The Heliospheric Termination Shock

    Science.gov (United States)

    Jokipii, J. R.

    2013-06-01

    The heliospheric termination shock is a vast, spheroidal shock wave marking the transition from the supersonic solar wind to the slower flow in the heliosheath, in response to the pressure of the interstellar medium. It is one of the most-important boundaries in the outer heliosphere. It affects energetic particles strongly and for this reason is a significant factor in the effects of the Sun on Galactic cosmic rays. This paper summarizes the general properties and overall large-scale structure and motions of the termination shock. Observations over the past several years, both in situ and remote, have dramatically revised our understanding of the shock. The consensus now is that the shock is quite blunt, is with the front, blunt side canted at an angle to the flow direction of the local interstellar plasma relative to the Sun, and is dynamical and turbulent. Much of this new understanding has come from remote observations of energetic charged particles interacting with the shock, radio waves and radiation backscattered from interstellar neutral atoms. The observations and the implications are discussed.

  13. Ageing shocks and short-run regional labour market dynamics in a spatial panel VAR approach

    DEFF Research Database (Denmark)

    Mitze, Timo; Schmidt, Torben Dall; Rauhut, Daniel

    2018-01-01

    Using a flexible spatial panel VAR model for a small-scale labour market system, we investigate the dynamic interdependences between changes in the demographic structure and the labour market performance of a regional economy. With a particular focus on ageing shocks, we describe an increase...... in the share of elderly in regional population due to exogenous changes in the institutional context, such as pension reforms. The regional labour market implications of an ageing shock are then tested with regard to the effects on employment growth, unemployment and labour participation rate. Our results...... based on a sample of 71 Scandinavian regions point to negative regional labour market effects of an ageing shock implying a reduction in employment growth and a temporarily declining labour participation rate, while the unemployment rate increases. Importantly, spatial spillovers amplify these negative...

  14. In vivo analysis of intestinal permeability following hemorrhagic shock

    Science.gov (United States)

    Alsaigh, Tom; Chang, Marisol; Richter, Michael; Mazor, Rafi; Kistler, Erik B

    2015-01-01

    AIM: To determine the time course of intestinal permeability changes to proteolytically-derived bowel peptides in experimental hemorrhagic shock. METHODS: We injected fluorescently-conjugated casein protein into the small bowel of anesthetized Wistar rats prior to induction of experimental hemorrhagic shock. These molecules, which fluoresce when proteolytically cleaved, were used as markers for the ability of proteolytically cleaved intestinal products to access the central circulation. Blood was serially sampled to quantify the relative change in concentration of proteolytically-cleaved particles in the systemic circulation. To provide spatial resolution of their location, particles in the mesenteric microvasculature were imaged using in vivo intravital fluorescent microscopy. The experiments were then repeated using an alternate measurement technique, fluorescein isothiocyanate (FITC)-labeled dextrans 20, to semi-quantitatively verify the ability of bowel-derived low-molecular weight molecules (< 20 kD) to access the central circulation. RESULTS: Results demonstrate a significant increase in systemic permeability to gut-derived peptides within 20 min after induction of hemorrhage (1.11 ± 0.19 vs 0.86 ± 0.07, P < 0.05) compared to control animals. Reperfusion resulted in a second, sustained increase in systemic permeability to gut-derived peptides in hemorrhaged animals compared to controls (1.2 ± 0.18 vs 0.97 ± 0.1, P < 0.05). Intravital microscopy of the mesentery also showed marked accumulation of fluorescent particles in the microcirculation of hemorrhaged animals compared to controls. These results were replicated using FITC dextrans 20 [10.85 ± 6.52 vs 3.38 ± 1.11 fluorescent intensity units (× 105, P < 0.05, hemorrhagic shock vs controls)], confirming that small bowel ischemia in response to experimental hemorrhagic shock results in marked and early increases in gut membrane permeability. CONCLUSION: Increased small bowel permeability in hemorrhagic

  15. Multiple shocks, coping and welfare consequences: natural disasters and health shocks in the Indian Sundarbans.

    Science.gov (United States)

    Mazumdar, Sumit; Mazumdar, Papiya Guha; Kanjilal, Barun; Singh, Prashant Kumar

    2014-01-01

    Based on a household survey in Indian Sundarbans hit by tropical cyclone Aila in May 2009, this study tests for evidence and argues that health and climatic shocks are essentially linked forming a continuum and with exposure to a marginal one, coping mechanisms and welfare outcomes triggered in the response is significantly affected. The data for this study is based on a cross-sectional household survey carried out during June 2010. The survey was aimed to assess the impact of cyclone Aila on households and consequent coping mechanisms in three of the worst-affected blocks (a sub-district administrative unit), viz. Hingalganj, Gosaba and Patharpratima. The survey covered 809 individuals from 179 households, cross cutting age and gender. A separate module on health-seeking behaviour serves as the information source of health shocks defined as illness episodes (ambulatory or hospitalized) experienced by household members. Finding reveals that over half of the households (54%) consider that Aila has dealt a high, damaging impact on their household assets. Result further shows deterioration of health status in the period following the incidence of Aila. Finding suggests having suffered multiple shocks increases the number of adverse welfare outcomes by 55%. Whereas, suffering either from the climatic shock (33%) or the health shock (25%) alone increases such risks by a much lesser extent. The multiple-shock households face a significantly higher degree of difficulty to finance expenses arising out of health shocks, as opposed to their counterparts facing only the health shock. Further, these households are more likely to finance the expenses through informal loans and credit from acquaintances or moneylenders. This paper presented empirical evidence on how natural and health shocks mutually reinforce their resultant impact, making coping increasingly difficult and present significant risks of welfare loss, having short as well as long-run development manifestations.

  16. Financial Restructuring after the 1997 Crisis and Impact of the Lehman Shock: Path Dependence of Financial Systems in Korea and Thailand

    OpenAIRE

    Okabe, Yasunobu

    2013-01-01

    After the 1997 Asian financial crisis, South Korea (Korea) and Thailand implemented financial restructuring in a similarly successful manner and regained the healthiness of their banking sectors. However, when the Lehman shock hit their financial markets in 2008, its impact on the two countries was quite different. Korea, which had performed better in the financial restructuring than Thailand, was driven to the brink of a second financial crisis in 2008 while Thailand weathered the shock easi...

  17. Contribution to the dynamic analysis of prestressed and preloaded spring-mass systems of variable structure under shock load

    International Nuclear Information System (INIS)

    Matthees, W.

    1980-01-01

    The purpose of this work is the development of a method to analyze on impact load structural systems whose topologically variable system arrangements are dependent on temporarily varying deformation conditions impact loads. This method serves to examine the prototype of a dynamically excited burst protection system for a nuclear power plant. Evidence is given that in case of hypothetical failure of the prestressed reactor pressure vessel the maximum load capacity of the reactor core is not exceeded, which in turn guarantees safe shutdown of the reactor. (orig./HP) [de

  18. Oil price shocks and economy: an open question

    International Nuclear Information System (INIS)

    Di Marzio, G.

    2006-01-01

    During the 1970s and 1980s advanced oil importing economies faced the adverse effects of oil supply disruptions with abrupt energy price rise, followed by sensible business cycle inversions and stagflation. The negative effects of the sharp energy price increase were amplified by factors such the induced costly resources reallocation between labour and capital, and between sectors of activity; rising uncertainty discouraging investments, and income redistribution consequences on aggregate demands After a shock the economic system generally adjusts in favour of less energy intensive industries; this leads pauses in production as part of the existing capital stock become obsolete, and causes resources under utilization. Since the 1970s a number of economists have been sceptical about why even large price shocks in a resource that accounts for less than 3-4 pct. of global GDP could cause losses of magnitude as those experienced in most advanced economies. They believe that monetary policy has played a role in generating the observed negative correlation between oil prices and economic activity, and question whether the post-oil-shock recessions were attributable to the oil price shocks themselves or to the monetary policy responding to these shocks. Empirical research largely shows a primary responsibility of large price shocks and major oil-supply disruptions on recessionary movements of GDP. Energy prices have risen sharply since 2003, driven by strengthening global demand; market fundamentals suggest that a considerable fraction of recent hikes will be permanent and current price levels remain credible. With limited spare capacity, the medium term oil supply-demand balance is expected to remain tight, and the price probably near current levels. Today' s high oil prices reflect the effects of sustained energy demand trends and, jointly, oil industry under investment during and after the low price era of the 1990s. The apparent moderate macro economic effects of the

  19. Shock-wave structure formation in a dusty plasma

    International Nuclear Information System (INIS)

    Popel', S.I.; Golub', A.P.; Loseva, T.V.; Bingkhem, R.; Benkadda, S.

    2001-01-01

    Nonstationary problem on evolution perturbation and its transformation into nonlinear wave structure is considered. The method developed permits finding solution to the system of nonlinear evolution equations describing dust particles with variable charge, Boltzmann electron and inertia ions. An accurate stationary solution as ion-sonic wave structures explained by anomalous dissipation due to electric discharge of dust particles was found. Evolution of two types of initial perturbations was studied, i.e.: soliton and immobile region with increased density of ions - a step. Soliton evolution in plasma with variable charge of dust particles results in the appearance on nonstationary shock-wave structure, whereas the step evolution gives rise to appearance of a shock wave similar to the stationary one along with rarefaction wave [ru

  20. Effectiveness of Ford's belt reminder system in increasing seat belt use

    OpenAIRE

    Williams, A; Wells, J; Farmer, C

    2002-01-01

    Objectives: The study investigated the effectiveness in increasing seat belt use of Ford's belt reminder system, a supplementary system that provides intermittent flashing lights and chimes for five minutes if drivers are not belted.

  1. Emissive spectra of shock-heated argon

    International Nuclear Information System (INIS)

    Tang Jingyou; Gu Yan; Peng Qixian; Bai Yulin; Li Ping

    2003-01-01

    To study the radiant properties of argon under weak shock compression, an aluminum target filled with gaseous argon at ambient states was impacted by a tungsten alloy projectile which was launched from a two-stage light gun to 2.00 km/s. The radiant signals of single shock-compressed argon were recorded by a six-channel pyrometer and oscilloscopes, which varied with time linearly for the five channels from 405 nm to 700 nm and exponentially for the channel 800 nm, and the corresponding velocity of shock wave was determined to be 4.10 ± 0.09 km/s. By the present experiment, it has been shown that the absorbability of the shock-heated argon is low for visual light and the optical depths of argon gas turn from thin to thick as wavelengths gradually increase. The time-resolved spectra in the rising-front of the radiant signal in the re-shocked argon were recorded by means of an OMA, and strong emissive spectrum bands near 450 nm light-wave length but no linear spectrum were found. The emissive spectrum properties of shock-compression argon were qualitatively explained by the state parameters and ionization degree

  2. Internal defibrillation: pain perception of low energy shocks.

    Science.gov (United States)

    Steinhaus, David M; Cardinal, Debbie S; Mongeon, Luc; Musley, Shailesh Kumar; Foley, Laura; Corrigan, Susie

    2002-07-01

    Recently, device-based low energy cardoversion shocks have been used as therapy for AF. However, discomfort from internal low energy electrical shocks is poorly understood. The aim of this study was to evaluate pain perception with low energy internal discharges. Eighteen patients with ICD devices for malignant ventricular arrhythmias were recruited to receive shocks of 0.4 and 2 J in the nonsedated state. Discharges were delivered in a blinded, random order and questionnaires were used to determine discomfort levels and tolerability. Patients perceived discharges at these energies as relatively uncomfortable, averaging a score of 7.3 on a discomfort scale of 0-10, and could not distinguish 0.4-J shocks from 2-J shocks. Second shocks were perceived as more uncomfortable than initial discharges, regardless of the order in which the shocks were delivered. Despite the perceived discomfort, 83% of patients stated that they would tolerate discharges of this magnitude once per month, and 44% would tolerate weekly discharges. Patients perceive low energy discharges as painful and cannot distinguish between shocks of 0.4 and 2 J. The results suggest that ICD systems developed to treat atrial tachyarrhythmias should minimize the number of shocks delivered to terminate an atrial tachyarrhythmia episode. The majority of the patients tolerated low energy shocks provided the discharges are infrequent (once per month).

  3. Thermophysical properties of multi-shock compressed dense argon.

    Science.gov (United States)

    Chen, Q F; Zheng, J; Gu, Y J; Chen, Y L; Cai, L C; Shen, Z J

    2014-02-21

    In contrast to the single shock compression state that can be obtained directly via experimental measurements, the multi-shock compression states, however, have to be calculated with the aid of theoretical models. In order to determine experimentally the multiple shock states, a diagnostic approach with the Doppler pins system (DPS) and the pyrometer was used to probe multiple shocks in dense argon plasmas. Plasma was generated by a shock reverberation technique. The shock was produced using the flyer plate impact accelerated up to ∼6.1 km/s by a two-stage light gas gun and introduced into the plenum argon gas sample, which was pre-compressed from the environmental pressure to about 20 MPa. The time-resolved optical radiation histories were determined using a multi-wavelength channel optical transience radiance pyrometer. Simultaneously, the particle velocity profiles of the LiF window was measured with multi-DPS. The states of multi-shock compression argon plasma were determined from the measured shock velocities combining the particle velocity profiles. We performed the experiments on dense argon plasmas to determine the principal Hugonoit up to 21 GPa, the re-shock pressure up to 73 GPa, and the maximum measure pressure of the fourth shock up to 158 GPa. The results are used to validate the existing self-consistent variational theory model in the partial ionization region and create new theoretical models.

  4. On the effects of monetary policy shocks in developing countries

    Directory of Open Access Journals (Sweden)

    Magda Kandil

    2014-06-01

    Full Text Available Using annual data for a sample of developing countries, the time-series evidence indicates the allocation of monetary policy shocks, both expansionary and contractionary, between price inflation and output growth. Subsequently, cross-country regressions evaluate factors that underlie the difference in these allocations and their implications. The real effects of monetary shocks increase as the elasticity of aggregate demand increases with respect to monetary shocks. Nonetheless, capacity constraints hamper the output adjustment to monetary shocks and increase price inflation. Across countries, trend output growth increases with the output response to monetary shocks. Consistent with the stabilizing function of monetary policy, the variability of output growth decreases in the face of monetary fluctuations across countries. In contrast, monetary fluctuations increase the trend and variability of price inflation across countries.

  5. Spherical strong-shock generation for shock-ignition inertial fusion

    Energy Technology Data Exchange (ETDEWEB)

    Theobald, W.; Seka, W.; Lafon, M.; Anderson, K. S.; Hohenberger, M.; Marshall, F. J.; Michel, D. T.; Solodov, A. A.; Stoeckl, C.; Edgell, D. H.; Yaakobi, B.; Shvydky, A. [Laboratory for Laser Energetics and Fusion Science Center, University of Rochester, Rochester, New York 14623 (United States); Nora, R.; Betti, R. [Laboratory for Laser Energetics and Fusion Science Center, University of Rochester, Rochester, New York 14623 (United States); Department of Mechanical Engineering and Department of Physics, University of Rochester, Rochester, New York 14623 (United States); Casner, A.; Reverdin, C. [CEA, DAM, DIF, F-91297 Arpajon (France); Ribeyre, X.; Vallet, A. [Université de Bordeaux-CNRS-CEA, CELIA (Centre Lasers Intenses et Applications) UMR 5107 F-33400 Talence (France); Peebles, J.; Beg, F. N. [University of California, San Diego, La Jolla, California 92093 (United States); and others

    2015-05-15

    Recent experiments on the Laboratory for Laser Energetics' OMEGA laser have been carried out to produce strong shocks in solid spherical targets with direct laser illumination. The shocks are launched at pressures of several hundred Mbars and reach Gbar upon convergence. The results are relevant to the validation of the shock-ignition scheme and to the development of an OMEGA experimental platform to study material properties at Gbar pressures. The experiments investigate the strength of the ablation pressure and the hot-electron production at incident laser intensities of ∼2 to 6 × 10{sup 15 }W/cm{sup 2} and demonstrate ablation pressures exceeding 300 Mbar, which is crucial to developing a shock-ignition target design for the National Ignition Facility. The timing of the x-ray flash from shock convergence in the center of the solid plastic target is used to infer the ablation and shock pressures. Laser–plasma instabilities produce hot-electrons with a moderate temperature (<100 keV). The instantaneous conversion efficiencies of laser power into hot-electron power reached up to ∼15% in the intensity spike. The large amount of hot electrons is correlated with an earlier x-ray flash and a strong increase in its magnitude. This suggests that hot electrons contribute to the augmentation of the shock strength.

  6. Shocks in fragile matter

    Science.gov (United States)

    Vitelli, Vincenzo

    2012-02-01

    Non-linear sound is an extreme phenomenon typically observed in solids after violent explosions. But granular media are different. Right when they unjam, these fragile and disordered solids exhibit vanishing elastic moduli and sound speed, so that even tiny mechanical perturbations form supersonic shocks. Here, we perform simulations in which two-dimensional jammed granular packings are continuously compressed, and demonstrate that the resulting excitations are strongly nonlinear shocks, rather than linear waves. We capture the full dependence of the shock speed on pressure and compression speed by a surprisingly simple analytical model. We also treat shear shocks within a simplified viscoelastic model of nearly-isostatic random networks comprised of harmonic springs. In this case, anharmonicity does not originate locally from nonlinear interactions between particles, as in granular media; instead, it emerges from the global architecture of the network. As a result, the diverging width of the shear shocks bears a nonlinear signature of the diverging isostatic length associated with the loss of rigidity in these floppy networks.

  7. Experimental study of micro-shock tube flow

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jin Ouk; Kim, Gyu Wan; Rasel, Md. Alim Iftakhar [Dept. of Mechanical Engineering, Andong National University, Andong (Korea, Republic of); Kim, Heuy Dong [Fire Research Center, Korea Institute of Civil Engineering and Building Technology, Hwasung (Korea, Republic of)

    2015-03-15

    The flow characteristics in micro shock tube are investigated experimentally. Studies were carried out using a stainless steel micro shock tube. Shock and expansion wave was measured using 8 pressure sensors. The initial pressure ratio was varied from 4.3 to 30.5, and the diameter of tube was also changed from 3 mm to 6 mm. Diaphragm conditions were varied using two types of diaphragms. The results obtained show that the shock strength in the tube becomes stronger for an increase in the initial pressure ratio and diameter of tube. For the thinner diaphragm, the highest shock strength was found among varied diaphragm condition. Shock attenuation was highly influenced by the diameter of tube.

  8. Reorganization of a hospital catering system increases food intake in patients with inadequate intake

    DEFF Research Database (Denmark)

    Freil, M; Nielsen, MA; Blitz, B

    2006-01-01

    Background : Low food intake is a frequent problem in undernourished hospital patients. Objective: To study whether a reorganization of a hospital catering system enabling patients to choose their evening meal individually, in combination with an increase in the energy density of the food....... Conclusions: Reorganization of a hospital catering system can increase energy and protein intake and reduce waste substantially....

  9. On a Stochastic Failure Model under Random Shocks

    Science.gov (United States)

    Cha, Ji Hwan

    2013-02-01

    In most conventional settings, the events caused by an external shock are initiated at the moments of its occurrence. In this paper, we study a new classes of shock model, where each shock from a nonhomogeneous Poisson processes can trigger a failure of a system not immediately, as in classical extreme shock models, but with delay of some random time. We derive the corresponding survival and failure rate functions. Furthermore, we study the limiting behaviour of the failure rate function where it is applicable.

  10. Nonequilibrium effects on shock-layer radiometry during earth entry.

    Science.gov (United States)

    Arnold, J. O.; Whiting, E. E.

    1973-01-01

    Radiative enhancement factors for the CN violet and N2(+) first negative band systems caused by nonequilibrium thermochemistry in the shock layer of a blunt-nosed vehicle during earth entry are reported. The results are based on radiometric measurements obtained with the aid of a combustion-driven shock tube. The technique of converting the shock-tube measurements into predictions of the enhancement factors for the blunt-body case is described, showing it to be useful for similar applications of other shock-tube measurements.

  11. A team-based approach to patients in cardiogenic shock.

    Science.gov (United States)

    Doll, Jacob A; Ohman, E Magnus; Patel, Manesh R; Milano, Carmelo A; Rogers, Joseph G; Wohns, David H; Kapur, Navin K; Rao, Sunil V

    2016-09-01

    Cardiogenic shock is a common clinical condition with high in-hospital mortality. Early application of appropriate interventions for cardiogenic shock-including medical therapies, revascularization, temporary hemodynamic support devices, and durable mechanical circulatory support-may improve outcomes. The number and complexity of therapies for cardiogenic shock are increasing, making time-dependent decision-making more challenging. A multidisciplinary cardiogenic shock team is recommended to guide the rapid and efficient use of these available treatments. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

  12. Physics of Collisionless Shocks Space Plasma Shock Waves

    CERN Document Server

    Balogh, André

    2013-01-01

    The present book provides a contemporary systematic treatment of shock waves in high-temperature collisionless plasmas as are encountered in near Earth space and in Astrophysics. It consists of two parts. Part I develops the complete theory of shocks in dilute hot plasmas under the assumption of absence of collisions among the charged particles when the interaction is mediated solely by the self-consistent electromagnetic fields. Such shocks are naturally magnetised implying that the magnetic field plays an important role in their evolution and dynamics. This part treats both subcritical shocks, which dissipate flow energy by generating anomalous resistance or viscosity, and supercritical shocks. The main emphasis is, however, on super-critical shocks where the anomalous dissipation is insufficient to retard the upstream flow. These shocks, depending on the direction of the upstream magnetic field, are distinguished as quasi-perpendicular and quasi-parallel shocks which exhibit different behaviours, reflecti...

  13. Ion transport in circulatory and/or septic shock

    International Nuclear Information System (INIS)

    Sayeed, M.M.

    1987-01-01

    This review surveys investigations of membrane ion transport in animals in hemorrhagic, endotoxic, or bacteremic shock. The focus of the review is on ion transport studies in the skeletal muscle and liver. Skeletal muscle Na + -K + transport alterations have been shown during the induction of shock via hemorrhage, endotoxin, or live Gram-negative bacteria in the rodent, canine, and primate species. These alterations include impairment of active cellular K + accumulation, increased permeability to 24 Na + and Cl - , and membrane depolarization. The ion transport alterations in the skeletal muscle are compatible with movement of extracellular fluid into the intracellular compartment. Such fluid movements can potentially lead to decreases in circulating plasma volume and thus to circulatory deficits in shock. Studies in the liver of rats subjected to hemorrhagic or endotoxic shock indicated the failure of electrogenic Na + pump. Although the hepatic cellular membrane permeability to Na + relative to permeability to K + appeared unaltered in hemorrhagic shock, endotoxic shock caused an increase in permeability to Na + . Hepatic cellular 45 Ca + regulation also appeared to be adversely affected during endotoxic shock. Alterations in hepatic Na + -K + transport and Ca + regulation could contribute to impairment in hepatic glucose production during shock. Although mechanisms of altered membrane ion transport during shock states remain unknown, such changes could occur prior to any substantial loss of cellular metabolic energy

  14. Reorganization of a hospital catering system increases food intake in patients with inadequate intake

    DEFF Research Database (Denmark)

    Freil, M.; Nielsen, M. A.; Biltz, C.

    2006-01-01

    Background: Low food intake is a frequent problem in undernourished hospital patients. Objective: To study whether a reorganization of a hospital catering system enabling patients to choose their evening meal individually, in combination with an increase in the energy density of the food, increases......: Reorganization of a hospital catering system can increase energy and protein intake and reduce waste substantially. Keywords: hospital food; nutritional risk; undernutrition...

  15. System of application of information technologies as a means of increasing education quality at the institute

    Directory of Open Access Journals (Sweden)

    Светлана Юрьевна Рубцова

    2009-09-01

    Full Text Available The article dwells on the essence of application of new information technologies in academic process at educational institution as one of the means of increasing quality of education. It will be achieved & supported by implementing automation education systems (AES based on module & system logics for preparing specialists, as well as working out & implementing didactic complex of automation education systems.

  16. Equally increased hypercoagulability irrespective of using minimized or conventional ECC systems

    DEFF Research Database (Denmark)

    Steinbrüchel, Ann S; Johansson, Pär I; Rafiq, Sulman

    2012-01-01

    Minimized extracorporeal circulation systems in coronary artery bypass may have less impairing effect on hematological parameters and bleeding compared to conventional systems. The aim of this study was to investigate whether the use of mini systems does result in an increased postoperative...

  17. Effects of black liquor shocks on activated sludge treatment of bleached kraft pulp mill wastewater.

    Science.gov (United States)

    Morales, Gabriela; Pesante, Silvana; Vidal, Gladys

    2015-01-01

    Kraft pulp mills use activated sludge systems to remove organic matter from effluents. Process streams may appear as toxic spills in treatment plant effluents, such as black liquor, which is toxic to microorganisms of the activated sludge. The present study evaluates the effects of black liquor shocks in activated sludge systems. Four black liquor shocks from 883 to 3,225 mg chemical oxygen demand-COD L(-1) were applied during 24 hours in a continuously operating lab-scale activated sludge system. Removal efficiencies of COD, color and specific compounds were determined. Moreover, specific oxygen uptake rate (SOUR), sludge volumetric index (SVI) and indicator microorganisms were evaluated. Results show that the addition of black liquor caused an increase in COD removal (76-67%) immediately post shock; followed two days later by a decrease (-19-50%). On the other hand, SOUR ranged between 0.152 and 0.336 mgO2 g(-1) volatile suspended solids-VSS• min(-1) during shocks, but the initial value was reestablished at hour 24. When the COD concentration of the shock was higher than 1,014 mg/L, the abundance of stalked ciliates and rotifers dropped. Finally, no changes in SVI were observed, with values remaining in the range 65.8-40.2 mL g(-1) total suspended solids-TSS during the entire operating process. Based on the results, the principal conclusion is that the activated sludge system with the biomass adapted to the kraft pulp effluent could resist a black liquor shock with 3,225 mgCOD L(-1) of concentration during 24 h, under this study's conditions.

  18. The Shock Routine

    DEFF Research Database (Denmark)

    van Hooren, Franca; Kaasch, Alexandra; Starke, Peter

    2014-01-01

    in Australia, Belgium, the Netherlands and Sweden over the course of four global economic shocks, we ask whether the notion of critical junctures is useful in understanding the nature of change triggered by crisis. The main empirical finding is that fundamental change in the aftermath of an exogenous shock...... is the exception rather than the rule. Instead, incremental ‘crisis routines’ based on existing policy instruments are overwhelmingly used to deal with economic hardship. We discuss these findings in the light of the psychological ‘threat-rigidity’ effect and reflect on their consequences for theories...

  19. Shock Transmission and Fatigue in Human Running.

    Science.gov (United States)

    Verbitsky, Oleg; Mizrahi, Joseph; Voloshin, Arkady; Treiger, July; Isakov, Eli

    1998-08-01

    The goal of this research was to analyze the effects of fatigue on the shock waves generated by foot strike. Twenty-two subjects were instrumented with an externally attached, lightweight accelerometer placed over the tibial tuberosity. The subjects ran on a treadmill for 30 min at a speed near their anaerobic threshold. Fatigue was established when the end-tidal CO 2 pressure decreased. The results indicated that approximately half of the subjects reached the fatigue state toward the end of the test. Whenever fatigue occurred, the peak acceleration was found to increase. It was thus concluded that there is a clear association between fatigue and increased heel strike-induced shock waves. These results have a significant implication for the etiology of running injuries, since shock wave attenuation has been previously reported to play an important role in preventing such injuries.

  20. Shock absorber in Ignalina NPP

    International Nuclear Information System (INIS)

    Bulavas, A.; Muralis, J.

    1996-09-01

    Theoretical calculation and experimental analysis of models of shock absorber in Ignalina NPP is presented. The results obtained from the investigation with model of shock absorber coincide with the theoretical calculation. (author). 2 figs., 3 refs

  1. Shock Response of Boron Carbide

    National Research Council Canada - National Science Library

    Dandekar, D. P. (Dattatraya Purushottam)

    2001-01-01

    .... The present work was undertaken to determine tensile/spall strength of boron carbide under plane shock wave loading and to analyze all available shock compression data on boron carbide materials...

  2. Fascinating World of Shock Waves

    Indian Academy of Sciences (India)

    Srimath

    travelling at supersonic speeds (more than the sound speed at ... actual earth- quake, travel at supersonic speeds. .... The time scale of the shock wave is also important ..... real lithotripsy where a shock wave is used shatter the kidney stones!

  3. Increasing income inequality

    DEFF Research Database (Denmark)

    Frederiksen, Anders; Poulsen, Odile

    In recent decades most developed countries have experienced an increase in income inequality. In this paper, we use an equilibrium search framework to shed additional light on what is causing an income distribution to change. The major benefit of the model is that it can accommodate shocks...... that shocks to the employees' relative productivity, i.e., skill-biased technological change, are unlikely to have caused the increase in income inequality....

  4. The Septic Shock 3.0 Definition and Trials: A Vasopressin and Septic Shock Trial Experience.

    Science.gov (United States)

    Russell, James A; Lee, Terry; Singer, Joel; Boyd, John H; Walley, Keith R

    2017-06-01

    The Septic Shock 3.0 definition could alter treatment comparisons in randomized controlled trials in septic shock. Our first hypothesis was that the vasopressin versus norepinephrine comparison and 28-day mortality of patients with Septic Shock 3.0 definition (lactate > 2 mmol/L) differ from vasopressin versus norepinephrine and mortality in Vasopressin and Septic Shock Trial. Our second hypothesis was that there are differences in plasma cytokine levels in Vasopressin and Septic Shock Trial for lactate less than or equal to 2 versus greater than 2 mmol/L. Retrospective analysis of randomized controlled trial. Multicenter ICUs. We compared vasopressin-to-norepinephrine group 28- and 90-day mortality in Vasopressin and Septic Shock Trial in lactate subgroups. We measured 39 cytokines to compare patients with lactate less than or equal to 2 versus greater than 2 mmol/L. Patients with septic shock with lactate greater than 2 mmol/L or less than or equal to 2 mmol/L, randomized to vasopressin or norepinephrine. Concealed vasopressin (0.03 U/min.) or norepinephrine infusions. The Septic Shock 3.0 definition would have decreased sample size by about half. The 28- and 90-day mortality rates were 10-12 % higher than the original Vasopressin and Septic Shock Trial mortality. There was a significantly (p = 0.028) lower mortality with vasopressin versus norepinephrine in lactate less than or equal to 2 mmol/L but no difference between treatment groups in lactate greater than 2 mmol/L. Nearly all cytokine levels were significantly higher in patients with lactate greater than 2 versus less than or equal to 2 mmol/L. The Septic Shock 3.0 definition decreased sample size by half and increased 28-day mortality rates by about 10%. Vasopressin lowered mortality versus norepinephrine if lactate was less than or equal to 2 mmol/L. Patients had higher plasma cytokines in lactate greater than 2 versus less than or equal to 2 mmol/L, a brisker cytokine response to infection. The Septic

  5. Network Capacity Assessment and Increase in Systems with Intermittent Water Supply

    OpenAIRE

    Ilaya-Ayza, Amilkar Ernesto; Campbell-Gonzalez, Enrique; Pérez García, Rafael; Izquierdo Sebastián, Joaquín

    2016-01-01

    [EN] Water supply systems have been facing many challenges in recent decades due to the potential effects of climate change and rapid population growth. Water systems need to expand because of demographic growth. Therefore, evaluating and increasing system capacity is crucial. Specifically, we analyze network capacity as one of the main features of a system. When the network capacity starts to decrease, there is a risk that continuous supply will become intermittent. This paper discusses how...

  6. Diffusive Shock Acceleration and Turbulent Reconnection

    Science.gov (United States)

    Garrel, Christian; Vlahos, Loukas; Isliker, Heinz; Pisokas, Theophilos

    2018-05-01

    Diffusive Shock Acceleration (DSA) cannot efficiently accelerate particles without the presence of self-consistently generated or pre-existing strong turbulence (δB/B ˜ 1) in the vicinity of the shock. The problem we address in this article is: if large amplitude magnetic disturbances are present upstream and downstream of a shock then Turbulent Reconnection (TR) will set in and will participate not only in the elastic scattering of particles but also in their heating and acceleration. We demonstrate that large amplitude magnetic disturbances and Unstable Current Sheets (UCS), spontaneously formed in the strong turbulence in the vicinity of a shock, can accelerate particles as efficiently as DSA in large scale systems and on long time scales. We start our analysis with "elastic" scatterers upstream and downstream and estimate the energy distribution of particles escaping from the shock, recovering the well known results from the DSA theory. Next we analyze the additional interaction of the particles with active scatterers (magnetic disturbances and UCS) upstream and downstream of the shock. We show that the asymptotic energy distribution of the particles accelerated by DSA/TR has very similar characteristics with the one due to DSA alone, but the synergy of DSA with TR is much more efficient: The acceleration time is an order of magnitude shorter and the maximum energy reached two orders of magnitude higher. We claim that DSA is the dominant acceleration mechanism in a short period before TR is established, and then strong turbulence will dominate the heating and acceleration of the particles. In other words, the shock serves as the mechanism to set up a strongly turbulent environment, in which the acceleration mechanism will ultimately be the synergy of DSA and TR.

  7. An overview on the small heat shock proteins

    African Journals Online (AJOL)

    USER

    2010-02-15

    Feb 15, 2010 ... whose expression is increase when cells are exposed to elevated ... shock due to much slower degradation of the protein, .... Plant sHSPs are all encoded by nuclear genes and are .... genesis, germination, pollen growth and fruit maturation). ... Production of high levels of heat shock proteins can also.

  8. A System Model of Increasing the Investment Potential of Technologically Unrelated Sectors

    Directory of Open Access Journals (Sweden)

    Melnyk Alexander G.

    2016-02-01

    Full Text Available The article presents a theoretical substantiation and the progress of practical application of the method for evaluating lagged effects of increasing the investment potential of interaction between industries in meso-level innovation systems on the example of the high-tech sector of Ukraine. The interaction data are considered in terms of their formation in such technologically unrelated sectors as the industrial sector and sector of education and sciences. It has been determined that the analytical basis to form the models of increasing the investment potential in innovation systems of meso-level should be presented by a comprehensive integrated assessment of all sectors involved in the reproduction process including technologically unrelated sectors of highly structured innovative systems. There has been proposed a system model of increasing the investment potential of the high-tech sector taking into account the optimization and synergy effects for system decisions concerning technologically unrelated sectors in economic systems of innovation type of reproduction.

  9. INTERFERENCE OF UNIDIRECTIONAL SHOCK WAVES

    Directory of Open Access Journals (Sweden)

    P. V. Bulat

    2015-05-01

    Full Text Available Subject of study.We consider interference of unidirectional shock waves or, as they are called, catching up shock waves. The scope of work is to give a classification of the shock-wave structures that arise in this type of interaction of shock waves, and the area of their existence. Intersection of unidirectional shock waves results in arising of a shock-wave structure at the intersection point, which contains the main shock wave, tangential discontinuity and one more reflected gas-dynamic discontinuity of unknown beforehand type. The problem of determining the type of reflected discontinuity is the main problem that one has to solve in the study of catching shock waves interference. Main results.The paper presents the pictures of shock-wave structures arising at the interaction of catching up shock waves. The areas with a regular and irregular unidirectional interaction of shocks are described. Characteristic shock-wave structures are of greatest interest, where reflected gas-dynamic discontinuity degenerates into discontinuous characteristics. Such structures have a number of extreme properties. We have found the areas of existence for such shock-wave structures. There are also areas in which the steady-state solution is not available. The latter has determined revival of interest for the theoretical study of the problem, because the facts of sudden shock-wave structure destruction inside the air intake of supersonic aircrafts at high Mach numbers have been discovered. Practical significance.The theory of interference for unidirectional shock waves and design procedure are usable in the design of supersonic air intakes. It is also relevant for application possibility investigation of catching up oblique shock waves to create overcompressed detonation in perspective detonation air-jet and rocket engines.

  10. Cost effective purification of intein based syntetic cationic antimicrobial peptide expressed in cold shock expression system using salt inducible E. coli GJ1158

    Directory of Open Access Journals (Sweden)

    Seetha Ram Kotra

    2014-03-01

    Full Text Available Objective:Synthetic cationic antimicrobial peptide (SC-AMP is an important and upcoming therapeutic molecule against onventional antibiotics. In this study, an attempt was made to purify the SC-AMP without the enzymatic cleavage of the affinity tag, by using an intein-based system. Methods:The intein sequence was amplified from pTYB11 vector using PCR methodologies and the N-terminal of intein was ligated with SC-AMP. The designed construct, intein-SC-AMP was cloned into MCS region of cold shock expression vector, pCOLDI and the recombinant peptide was purified on a chitin affinity column by cleaving intein with 50 mM DTT without applying enzymatic cleavage. Later the peptide was quantified and its antibacterial activity of the purified peptide was studied using well diffusion method. Results: Initially, intein-SC-AMP was expressed as a fusion protein in both IPTG inducible E. coli BL21(DE3 and salt inducible E. coli GJ1158. Single step purification using CBD (chitin binding domain - intein tag in salt inducible E. coli GJ1158, yields the SC-AMP in the soluble form at a oncentration of 208 mg/L. The antibacterial activity and minimal inhibitory concentration (MIC of the purified SC-AMP was studied against both Gram positive and Gram negative microorganisms. Conclusion: For the first time, single step purification of soluble SC-AMP was carried out using chitin-binding domain affinity tag in salt inducible E. coli GJ1158 without an application of enzymatic cleavage. J Microbiol Infect Dis 2014;4(1:13-19

  11. Structure of fast shocks in the presence of heat conduction

    International Nuclear Information System (INIS)

    Tsai, C. L.; Chen, H. H.; Wu, B. H.; Lee, L. C.

    2007-01-01

    There are three types of magnetohydrodynamic (MHD) shocks: the fast shock, intermediate shock, and slow shock. The structure of slow shocks and intermediate shocks in the presence of heat conduction has been studied earlier [C. L. Tsai, R. H. Tsai, B. H. Wu, and L. C. Lee, Phys. Plasmas 9, 1185 (2002); C. L. Tsai, B. H. Wu, and L. C. Lee, Phys. Plasmas 12, 82501 (2005)]. Based on one-dimensional MHD numerical simulations with a heat conduction term, the evolution and structure of fast shocks are studied. The fast shock will form a foreshock in the presence of heat conduction. The foreshock is formed due to the heat flow from downstream to upstream and located in the immediate upstream of the main shock. In the steady state, the value of diffusion velocity V d in the foreshock is found to nearly equal the upstream convection velocity in the fast shock frame. It is found that the density jump across the main shock in high Mach number case can be much larger than 4 in the early simulation time. However the density jump will gradually evolve to a value smaller than 4 at steady state. By using the modified Rankine-Hugoniot relations with heat flux, the density jump across the fast shock is examined for various upstream parameters. The results show that the calculated density jump with heat flux is very close to the simulation value and the density jump can far exceed the maximum value of 4 without heat conduction. The structure of foreshock and main shock is also studied under different plasma parameters, such as the heat conductivity K 0 , the ratio of upstream plasma pressure to magnetic pressure β 1 , Alfven Mach number M A1 , and the angle θ 1 between shock normal and magnetic field. It is found that as the upstream shock parameters K 0 , β 1 , and M A1 increase or θ 1 decreases, the width of foreshock L d increases. The present results can be applied to fast shocks in the solar corona, solar wind, and magnetosphere, in which the heat conduction effects are

  12. Shock tube Multiphase Experiments

    Science.gov (United States)

    Middlebrooks, John; Allen, Roy; Paudel, Manoj; Young, Calvin; Musick, Ben; McFarland, Jacob

    2017-11-01

    Shock driven multiphase instabilities (SDMI) are unique physical phenomena that have far-reaching practical applications in engineering and science. The instability is present in high energy explosions, scramjet combustors, and supernovae events. The SDMI arises when a multiphase interface is impulsively accelerated by the passage of a shockwave. It is similar in development to the Richtmyer-Meshkov (RM) instability however, particle-to-gas coupling is the driving mechanism of the SDMI. As particle effects such as lag and phase change become more prominent, the SDMI's development begins to significantly deviate from the RM instability. We have developed an experiment for studying the SDMI in our shock tube facility. In our experiments, a multiphase interface is created using a laminar jet and flowed into the shock tube where it is accelerated by the passage of a planar shockwave. The interface development is captured using CCD cameras synchronized with planar laser illumination. This talk will give an overview of new experiments conducted to examine the development of a shocked cylindrical multiphase interface. The effects of Atwood number, particle size, and a second acceleration (reshock) of the interface will be discussed.

  13. Properties of Merger Shocks in Merging Galaxy Clusters

    Science.gov (United States)

    Ha, Ji-Hoon; Ryu, Dongsu; Kang, Hyesung

    2018-04-01

    X-ray shocks and radio relics detected in the cluster outskirts are commonly interpreted as shocks induced by mergers of subclumps. We study the properties of merger shocks in merging galaxy clusters, using a set of cosmological simulations for the large-scale structure formation of the universe. As a representative case, we focus on the simulated clusters that undergo almost head-on collisions with mass ratio ∼2. Due to the turbulent nature of the intracluster medium, shock surfaces are not smooth, but composed of shocks with different Mach numbers. As the merger shocks expand outward from the core to the outskirts, the average Mach number, , increases in time. We suggest that the shocks propagating along the merger axis could be manifested as X-ray shocks and/or radio relics. The kinetic energy through the shocks, F ϕ , peaks at ∼1 Gyr after their initial launching, or at ∼1–2 Mpc from the core. Because of the Mach number dependent model adopted here for the cosmic-ray (CR) acceleration efficiency, their CR-energy-weighted Mach number is higher with }CR}∼ 3{--}4, compared to the kinetic-energy-weighted Mach number, }φ ∼ 2{--}3. Most energetic shocks are to be found ahead of the lighter dark matter (DM) clump, while the heavier DM clump is located on the opposite side of clusters. Although our study is limited to the merger case considered, the results such as the means and variations of shock properties and their time evolution could be compared with the observed characteristics of merger shocks, constraining interpretations of relevant observations.

  14. STEREO interplanetary shocks and foreshocks

    International Nuclear Information System (INIS)

    Blanco-Cano, X.; Kajdič, P.; Aguilar-Rodríguez, E.; Russell, C. T.; Jian, L. K.; Luhmann, J. G.

    2013-01-01

    We use STEREO data to study shocks driven by stream interactions and the waves associated with them. During the years of the extended solar minimum 2007-2010, stream interaction shocks have Mach numbers between 1.1-3.8 and θ Bn ∼20-86°. We find a variety of waves, including whistlers and low frequency fluctuations. Upstream whistler waves may be generated at the shock and upstream ultra low frequency (ULF) waves can be driven locally by ion instabilities. The downstream wave spectra can be formed by both, locally generated perturbations, and shock transmitted waves. We find that many quasiperpendicular shocks can be accompanied by ULF wave and ion foreshocks, which is in contrast to Earth's bow shock. Fluctuations downstream of quasi-parallel shocks tend to have larger amplitudes than waves downstream of quasi-perpendicular shocks. Proton foreshocks of shocks driven by stream interactions have extensions dr ≤0.05 AU. This is smaller than foreshock extensions for ICME driven shocks. The difference in foreshock extensions is related to the fact that ICME driven shocks are formed closer to the Sun and therefore begin to accelerate particles very early in their existence, while stream interaction shocks form at ∼1 AU and have been producing suprathermal particles for a shorter time.

  15. STEREO interplanetary shocks and foreshocks

    Energy Technology Data Exchange (ETDEWEB)

    Blanco-Cano, X. [Instituto de Geofisica, UNAM, CU, Coyoacan 04510 DF (Mexico); Kajdic, P. [IRAP-University of Toulouse, CNRS, Toulouse (France); Aguilar-Rodriguez, E. [Instituto de Geofisica, UNAM, Morelia (Mexico); Russell, C. T. [ESS and IGPP, University of California, Los Angeles, 603 Charles Young Drive, Los Angeles, CA 90095 (United States); Jian, L. K. [NASA Goddard Space Flight Center, Greenbelt, MD and University of Maryland, College Park, MD (United States); Luhmann, J. G. [SSL, University of California Berkeley (United States)

    2013-06-13

    We use STEREO data to study shocks driven by stream interactions and the waves associated with them. During the years of the extended solar minimum 2007-2010, stream interaction shocks have Mach numbers between 1.1-3.8 and {theta}{sub Bn}{approx}20-86 Degree-Sign . We find a variety of waves, including whistlers and low frequency fluctuations. Upstream whistler waves may be generated at the shock and upstream ultra low frequency (ULF) waves can be driven locally by ion instabilities. The downstream wave spectra can be formed by both, locally generated perturbations, and shock transmitted waves. We find that many quasiperpendicular shocks can be accompanied by ULF wave and ion foreshocks, which is in contrast to Earth's bow shock. Fluctuations downstream of quasi-parallel shocks tend to have larger amplitudes than waves downstream of quasi-perpendicular shocks. Proton foreshocks of shocks driven by stream interactions have extensions dr {<=}0.05 AU. This is smaller than foreshock extensions for ICME driven shocks. The difference in foreshock extensions is related to the fact that ICME driven shocks are formed closer to the Sun and therefore begin to accelerate particles very early in their existence, while stream interaction shocks form at {approx}1 AU and have been producing suprathermal particles for a shorter time.

  16. Vorticity dynamics after the shock-turbulence interaction

    Science.gov (United States)

    Livescu, D.; Ryu, J.

    2016-05-01

    The interaction of a shock wave with quasi-vortical isotropic turbulence (IT) represents a basic problem for studying some of the phenomena associated with high speed flows, such as hypersonic flight, supersonic combustion and Inertial Confinement Fusion (ICF). In general, in practical applications, the shock width is much smaller than the turbulence scales and the upstream turbulent Mach number is modest. In this case, recent high resolution shock-resolved Direct Numerical Simulations (DNS) (Ryu and Livescu, J Fluid Mech 756:R1, 2014) show that the interaction can be described by the Linear Interaction Approximation (LIA). Using LIA to alleviate the need to resolve the shock, DNS post-shock data can be generated at much higher Reynolds numbers than previously possible. Here, such results with Taylor Reynolds number approximately 180 are used to investigate the changes in the vortical structure as a function of the shock Mach number, Ms, up to Ms=10. It is shown that, as Ms increases, the shock interaction induces a tendency towards a local axisymmetric state perpendicular to the shock front, which has a profound influence on the vortex-stretching mechanism and divergence of the Lamb vector and, ultimately, on the flow evolution away from the shock.

  17. Compaction shock dissipation in low density granular explosive

    Energy Technology Data Exchange (ETDEWEB)

    Rao, Pratap T.; Gonthier, Keith A., E-mail: gonthier@me.lsu.edu; Chakravarthy, Sunada [Mechanical and Industrial Engineering Department, Louisiana State University, Baton Rouge, Louisiana 70803 (United States)

    2016-06-14

    The microstructure of granular explosives can affect dissipative heating within compaction shocks that can trigger combustion and initiate detonation. Because initiation occurs over distances that are much larger than the mean particle size, homogenized (macroscale) theories are often used to describe local thermodynamic states within and behind shocks that are regarded as the average manifestation of thermodynamic fields at the particle scale. In this paper, mesoscale modeling and simulation are used to examine how the initial packing density of granular HMX (C{sub 4}H{sub 8}N{sub 8}O{sub 8}) C{sub 4}H{sub 8}N{sub 8}O{sub 8} having a narrow particle size distribution influences dissipation within resolved, planar compaction shocks. The model tracks the evolution of thermomechanical fields within large ensembles of particles due to pore collapse. Effective shock profiles, obtained by averaging mesoscale fields over space and time, are compared with those given by an independent macroscale compaction theory that predicts the variation in effective thermomechanical fields within shocks due to an imbalance between the solid pressure and a configurational stress. Reducing packing density is shown to reduce the dissipation rate within shocks but increase the integrated dissipated work over shock rise times, which is indicative of enhanced sensitivity. In all cases, dissipated work is related to shock pressure by a density-dependent power law, and shock rise time is related to pressure by a power law having an exponent of negative one.

  18. Electromagnetic Structure and Electron Acceleration in Shock–Shock Interaction

    Energy Technology Data Exchange (ETDEWEB)

    Nakanotani, Masaru [Interdisciplinary Graduate School of Engineering Sciences, Kyushu University, 6-1 Kasuga-Koen, Kasuga, Fukuoka, 816-8580 (Japan); Matsukiyo, Shuichi; Hada, Tohru [Faculty of Engineering Sciences, Kyushu University, 6-1 Kasuga-Koen, Kasuga, Fukuoka, 816-8580 (Japan); Mazelle, Christian X., E-mail: nakanot@esst.kyushu-u.ac.jp [IRAP, Université Paul Sabatier Toulouse III-CNRS, F-31028 Toulouse Cedex 4 (France)

    2017-09-10

    A shock–shock interaction is investigated by using a one-dimensional full particle-in-cell simulation. The simulation reproduces the collision of two symmetrical high Mach number quasi-perpendicular shocks. The basic structure of the shocks and ion dynamics is similar to that obtained by previous hybrid simulations. The new aspects obtained here are as follows. Electrons are already strongly accelerated before the two shocks collide through multiple reflection. The reflected electrons self-generate waves upstream between the two shocks before they collide. The waves far upstream are generated through the right-hand resonant instability with the anomalous Doppler effect. The waves generated near the shock are due to firehose instability and have much larger amplitudes than those due to the resonant instability. The high-energy electrons are efficiently scattered by the waves so that some of them gain large pitch angles. Those electrons can be easily reflected at the shock of the other side. The accelerated electrons form a power-law energy spectrum. Due to the accelerated electrons, the pressure of upstream electrons increases with time. This appears to cause the deceleration of the approaching shock speed. The accelerated electrons having sufficiently large Larmor radii are further accelerated through the similar mechanism working for ions when the two shocks are colliding.

  19. Coaxial Tubing Systems Increase Artificial Airway Resistance and Work of Breathing.

    Science.gov (United States)

    Wenzel, Christin; Schumann, Stefan; Spaeth, Johannes

    2017-09-01

    Tubing systems are an essential component of the ventilation circuit, connecting the ventilator to the patient's airways. Coaxial tubing systems incorporate the inspiratory tube within the lumen of the expiratory one. We hypothesized that by design, these tubing systems increase resistance to air flow compared with conventional ones. We investigated the flow-dependent pressure gradient across coaxial, conventional disposable, and conventional reusable tubing systems from 3 different manufacturers. Additionally, the additional work of breathing and perception of resistance during breathing through the different devices were determined in 18 healthy volunteers. The pressure gradient across coaxial tubing systems was up to 6 times higher compared with conventional ones (1.90 ± 0.03 cm H 2 O vs 0.34 ± 0.01 cm H 2 O, P tubing systems, accordingly. Our findings suggest that the use of coaxial tubing systems should be carefully considered with respect to their increased resistance. Copyright © 2017 by Daedalus Enterprises.

  20. Perspectives on aetiology, pathophysiology and management of shock in African children

    Directory of Open Access Journals (Sweden)

    Julius Nteziyaremye

    Full Text Available Paediatric shock is still a common emergency of public health importance with an estimated 400,000–500,000 reported cases annually. Mortality due to paediatric shock has varied over the years. Data in 1980s show that mortality rates due to septic shock in children were over 50%; but by the end of the year 2000 data indicated that though a marked decline in mortality rates had been achieved, it had stagnated at about 20%. Descriptions of paediatric shock reveal the lack of a common definition and there are important gaps in evidence-based management in different settings. In well-resourced healthcare systems with well-functioning intensive care facilities, the widespread implementation of shock management guidelines based on the Paediatric Advanced Life Support and European Paediatric Advanced Life Support courses have reduced mortality. In resource limited settings with diverse infectious causative agents, the Emergency Triage Assessment and Treatment (ETAT approach is more pragmatic, but its impact remains circumscribed to centres where ETAT has been implemented and sustained. Advocacy for common management pathways irrespective of underlying cause have been suggested. However, in sub Saharan Africa, the diversity of underlying causative organisms and patient phenotypes may limit a single approach to shock management.Data from a large fluid trial (the FEAST trial in East Africa have provided vital insight to shock management. In this trial febrile children with clinical features of impaired perfusion were studied. Rapid infusion of fluid boluses, irrespective of whether the fluid was colloid or crystalloid, when compared to maintenance fluids alone had an increased risk of mortality at 48 h. All study participants were promptly managed for underlying conditions and comorbidity such as malaria, bacteraemia, severe anaemia, meningitis, pneumonia, convulsions, hypoglycaemia and others. The overall low mortality in the trial suggests the

  1. Participatory System Dynamics Modeling: Increasing Stakeholder Engagement and Precision to Improve Implementation Planning in Systems.

    Science.gov (United States)

    Zimmerman, Lindsey; Lounsbury, David W; Rosen, Craig S; Kimerling, Rachel; Trafton, Jodie A; Lindley, Steven E

    2016-11-01

    Implementation planning typically incorporates stakeholder input. Quality improvement efforts provide data-based feedback regarding progress. Participatory system dynamics modeling (PSD) triangulates stakeholder expertise, data and simulation of implementation plans prior to attempting change. Frontline staff in one VA outpatient mental health system used PSD to examine policy and procedural "mechanisms" they believe underlie local capacity to implement evidence-based psychotherapies (EBPs) for PTSD and depression. We piloted the PSD process, simulating implementation plans to improve EBP reach. Findings indicate PSD is a feasible, useful strategy for building stakeholder consensus, and may save time and effort as compared to trial-and-error EBP implementation planning.

  2. Shock Dynamics in Stellar Outbursts. I. Shock Formation

    Energy Technology Data Exchange (ETDEWEB)

    Ro, Stephen; Matzner, Christopher D., E-mail: ro@astro.utoronto.ca [Department of Astronomy and Astrophysics, University of Toronto, 50 St. George Street, Toronto, ON M5S 3H4 (Canada)

    2017-05-20

    Wave-driven outflows and non-disruptive explosions have been implicated in pre-supernova outbursts, supernova impostors, luminous blue variable eruptions, and some narrow-line and superluminous supernovae. To model these events, we investigate the dynamics of stars set in motion by strong acoustic pulses and wave trains, focusing on nonlinear wave propagation, shock formation, and an early phase of the development of a weak shock. We identify the shock formation radius, showing that a heuristic estimate based on crossing characteristics matches an exact expansion around the wave front and verifying both with numerical experiments. Our general analytical condition for shock formation applies to one-dimensional motions within any static environment, including both eruptions and implosions. We also consider the early phase of shock energy dissipation. We find that waves of super-Eddington acoustic luminosity always create shocks, rather than damping by radiative diffusion. Therefore, shock formation is integral to super-Eddington outbursts.

  3. Examining the impacts of increased corn production on groundwater quality using a coupled modeling system

    Science.gov (United States)

    This study demonstrates the value of a coupled chemical transport modeling system for investigating groundwater nitrate contamination responses associated with nitrogen (N) fertilizer application and increased corn production. The coupled Community Multiscale Air Quality Bidirect...

  4. Shock interactions with heterogeneous energetic materials

    Science.gov (United States)

    Yarrington, Cole D.; Wixom, Ryan R.; Damm, David L.

    2018-03-01

    The complex physical phenomenon of shock wave interaction with material heterogeneities has significant importance and nevertheless remains little understood. In many materials, the observed macroscale response to shock loading is governed by characteristics of the microstructure. Yet, the majority of computational studies aimed at predicting phenomena affected by these processes, such as the initiation and propagation of detonation waves in explosives or shock propagation in geological materials, employ continuum material and reactive burn model treatment. In an effort to highlight the grain-scale processes that underlie the observable effects in an energetic system, a grain-scale model for hexanitrostilbene (HNS) has been developed. The measured microstructures were used to produce synthetic computational representations of the pore structure, and a density functional theory molecular dynamics derived equation of state (EOS) was used for the fully dense HNS matrix. The explicit inclusion of the microstructure along with a fully dense EOS resulted in close agreement with historical shock compression experiments. More recent experiments on the dynamic reaction threshold were also reproduced by inclusion of a global kinetics model. The complete model was shown to reproduce accurately the expected response of this heterogeneous material to shock loading. Mesoscale simulations were shown to provide a clear insight into the nature of threshold behavior and are a way to understand complex physical phenomena.

  5. Advances in NIF Shock Timing Experiments

    Science.gov (United States)

    Robey, Harry

    2012-10-01

    Experiments are underway to tune the shock timing of capsule implosions on the National Ignition Facility (NIF). These experiments use a modified cryogenic hohlraum geometry designed to precisely match the performance of ignition hohlraums. The targets employ a re-entrant Au cone to provide optical access to multiple shocks as they propagate in the liquid deuterium-filled capsule interior. The strength and timing of all four shocks is diagnosed with VISAR (Velocity Interferometer System for Any Reflector). Experiments are now routinely conducted in a mirrored keyhole geometry, which allows for simultaneous diagnosis of the shock timing at both the hohlraum pole and equator. Further modifications are being made to improve the surrogacy to ignition hohlraums by replacing the standard liquid deuterium (D2) capsule fill with a deuterium-tritium (DT) ice layer. These experiments will remove any possible surrogacy difference between D2 and DT as well as incorporate the physics of shock release from the ice layer, which is absent in current experiments. Experimental results and comparisons with numerical simulation are presented.

  6. A numerical study of fundamental shock noise mechanisms. Ph.D. Thesis - Cornell Univ.

    Science.gov (United States)

    Meadows, Kristine R.

    1995-01-01

    The results of this thesis demonstrate that direct numerical simulation can predict sound generation in unsteady aerodynamic flows containing shock waves. Shock waves can be significant sources of sound in high speed jet flows, on helicopter blades, and in supersonic combustion inlets. Direct computation of sound permits the prediction of noise levels in the preliminary design stage and can be used as a tool to focus experimental studies, thereby reducing cost and increasing the probability of a successfully quiet product in less time. This thesis reveals and investigates two mechanisms fundamental to sound generation by shocked flows: shock motion and shock deformation. Shock motion is modeled by the interaction of a sound wave with a shock. During the interaction, the shock wave begins to move and the sound pressure is amplified as the wave passes through the shock. The numerical approach presented in this thesis is validated by the comparison of results obtained in a quasi-one dimensional simulation with linear theory. Analysis of the perturbation energy demonstrated for the first time that acoustic energy is generated by the interaction. Shock deformation is investigated by the numerical simulation of a ring vortex interacting with a shock. This interaction models the passage of turbulent structures through the shock wave. The simulation demonstrates that both acoustic waves and contact surfaces are generated downstream during the interaction. Analysis demonstrates that the acoustic wave spreads cylindrically, that the sound intensity is highly directional, and that the sound pressure level increases significantly with increasing shock strength. The effect of shock strength on sound pressure level is consistent with experimental observations of shock noise, indicating that the interaction of a ring vortex with a shock wave correctly models a dominant mechanism of shock noise generation.

  7. Dopamine versus noradrenaline in septic shock

    Directory of Open Access Journals (Sweden)

    Bo Xu

    2011-10-01

    Full Text Available BackgroundThe ‘Surviving Sepsis’ Campaign guidelines recommend theuse of dopamine or noradrenaline as the first vasopressor inseptic shock. However, information that guides clinicians inchoosing between dopamine and noradrenaline as the firstvasopressor in patients with septic shock is limited.ObjectiveThis article presents a review of the literature regarding theuse of dopamine versus noradrenaline in patients with septicshock.ResultsTwo randomised controlled trials (RCT and two largeprospective cohort studies were analysed. RCT data showeddopamine was associated with increased arrhythmic events.One cohort study found dopamine was associated with higher30-day mortality. The other cohort study found noradrenalinewas associated with higher 28-day mortality.DiscussionData on the use of dopamine versus noradrenaline in patientswith septic shock is limited. Following the recent SOAP IIstudy, there is now strong evidence that the use of dopaminein septic shock is associated with significantly morecardiovascular adverse events, compared tonoradrenaline.ConclusionNoradrenaline should be used as the initial vasopressor inseptic shock to avoid the arrhythmic events associatedwith dopamine.

  8. Biophysical analysis of bacterial and viral systems. A shock tube study of bio-aerosols and a correlated AFM/nanosims investigation of vaccinia virus

    Energy Technology Data Exchange (ETDEWEB)

    Gates, Sean Damien [Stanford Univ., CA (United States)

    2013-05-01

    The work presented herein is concerned with the development of biophysical methodology designed to address pertinent questions regarding the behavior and structure of select pathogenic agents. Two distinct studies are documented: a shock tube analysis of endospore-laden bio-aerosols and a correlated AFM/NanoSIMS study of the structure of vaccinia virus.

  9. Efficiency increase in ship's primal energy system using a multistage compression with intercooling

    Directory of Open Access Journals (Sweden)

    Landeka Petar

    2016-01-01

    Full Text Available This paper focuses on an analysis of the potential increase of efficiency in ship's primal energy system using a turbocharger with multistage compression with intercooling, and diverting a greater flow of exhaust gases to power turbine of waste heat recovery system (WHR. Analysis of potential efficiency increase has been made for various stages of compression for a 100 % main engine load, and an analysis of five stage compression with intercooling for a main engine load between 50% and 100%.

  10. Application of fuzzy inference system to increase efficiency of management decision-making in agricultural enterprises

    OpenAIRE

    Balanovskаya, Tetiana Ivanovna; Boretska, Zoreslava Petrovna

    2014-01-01

    Application of fuzzy inference system to increase efficiency of management decision- making in agricultural enterprises. Theoretical and methodological issues, practical recommendations on improvement of management decision-making in agricultural enterprises to increase their competitiveness have been intensified and developed in the article. A simulation example of a quality management system for agricultural products on the basis of the theory of fuzzy sets and fuzzy logic has been proposed...

  11. Parametric study of non-relativistic electrostatic shocks and the structure of their transition layer

    Energy Technology Data Exchange (ETDEWEB)

    Dieckmann, M. E. [Institute of Physics and Astronomy, University of Potsdam, D-14476 Potsdam (Germany); Department of Science and Technology, Linkoeping University, SE-60174 Norrkoeping (Sweden); Ahmed, H.; Sarri, G.; Doria, D.; Kourakis, I.; Borghesi, M. [Centre for Plasma Physics, School of Mathematics and Physics, Queen' s University of Belfast, Belfast BT7 1NN (United Kingdom); Romagnani, L. [LULI, Ecole Polytechnique, CNRS, CEA, UPMC, 91128 Palaiseau (France); Pohl, M. [Institute of Physics and Astronomy, University of Potsdam, D-14476 Potsdam (Germany); DESY, D-15738 Zeuthen (Germany)

    2013-04-15

    Nonrelativistic electrostatic unmagnetized shocks are frequently observed in laboratory plasmas and they are likely to exist in astrophysical plasmas. Their maximum speed, expressed in units of the ion acoustic speed far upstream of the shock, depends only on the electron-to-ion temperature ratio if binary collisions are absent. The formation and evolution of such shocks is examined here for a wide range of shock speeds with particle-in-cell simulations. The initial temperatures of the electrons and the 400 times heavier ions are equal. Shocks form on electron time scales at Mach numbers between 1.7 and 2.2. Shocks with Mach numbers up to 2.5 form after tens of inverse ion plasma frequencies. The density of the shock-reflected ion beam increases and the number of ions crossing the shock thus decreases with an increasing Mach number, causing a slower expansion of the downstream region in its rest frame. The interval occupied by this ion beam is on a positive potential relative to the far upstream. This potential pre-heats the electrons ahead of the shock even in the absence of beam instabilities and decouples the electron temperature in the foreshock ahead of the shock from the one in the far upstream plasma. The effective Mach number of the shock is reduced by this electron heating. This effect can potentially stabilize nonrelativistic electrostatic shocks moving as fast as supernova remnant shocks.

  12. Parametric study of non-relativistic electrostatic shocks and the structure of their transition layer

    International Nuclear Information System (INIS)

    Dieckmann, M. E.; Ahmed, H.; Sarri, G.; Doria, D.; Kourakis, I.; Borghesi, M.; Romagnani, L.; Pohl, M.

    2013-01-01

    Nonrelativistic electrostatic unmagnetized shocks are frequently observed in laboratory plasmas and they are likely to exist in astrophysical plasmas. Their maximum speed, expressed in units of the ion acoustic speed far upstream of the shock, depends only on the electron-to-ion temperature ratio if binary collisions are absent. The formation and evolution of such shocks is examined here for a wide range of shock speeds with particle-in-cell simulations. The initial temperatures of the electrons and the 400 times heavier ions are equal. Shocks form on electron time scales at Mach numbers between 1.7 and 2.2. Shocks with Mach numbers up to 2.5 form after tens of inverse ion plasma frequencies. The density of the shock-reflected ion beam increases and the number of ions crossing the shock thus decreases with an increasing Mach number, causing a slower expansion of the downstream region in its rest frame. The interval occupied by this ion beam is on a positive potential relative to the far upstream. This potential pre-heats the electrons ahead of the shock even in the absence of beam instabilities and decouples the electron temperature in the foreshock ahead of the shock from the one in the far upstream plasma. The effective Mach number of the shock is reduced by this electron heating. This effect can potentially stabilize nonrelativistic electrostatic shocks moving as fast as supernova remnant shocks.

  13. Fuel-coolant interactions in a shock-tube geometry

    International Nuclear Information System (INIS)

    Segev, A.; Henry, R.E.; Bankoff, S.G.

    1978-01-01

    Thermal interactions were studied in a shock tube configuration using different pairs of liquids. Large pressures were obtained for systems of water-Wood's metal and butanol-Wood's metal. Different types of interactions were observed, depending on the hot liquid temperature. It was found that thehydrodynamic component alone may account for the measured pressure in the lower temperature range. A combination of thermal and hydrodynamic interactions accounts for the pressures at high temperatures. Experiments with water and molten salt (LiCl + KCl) produced small scale explosions. All interactions were suppressed when driving pressure increased. (author)

  14. Grain destruction in interstellar shocks

    International Nuclear Information System (INIS)

    Seab, C.G.; Shull, J.M.

    1984-01-01

    One of the principal methods for removing grains from the Interstellar Medium is to destroy them in shock waves. Previous theoretical studies of shock destruction have generally assumed only a single size and type of grain; most do not account for the effect of the grain destruction on the structure of the shock. Earlier calculations have been improved in three ways: first, by using a ''complete'' grain model including a distribution of sizes and types of grains; second, by using a self-consistent shock structure that incorporates the changing elemental depletions as the grains are destroyed; and third, by calculating the shock-processed ultraviolet extinction curves for comparison with observations. (author)

  15. Implementing Work Systems across the School Day: Increasing Engagement in Students with Autism Spectrum Disorders

    Science.gov (United States)

    Hume, Kara; Reynolds, Beth

    2010-01-01

    Work systems provide visual information and organization for students with autism spectrum disorders (ASD) and assist in increasing on-task behavior and productivity while simultaneously decreasing adult prompting. Work systems are a core component of the Treatment and Education of Autistic and Related Communication-Handicapped Children…

  16. Riemann solvers and undercompressive shocks of convex FPU chains

    International Nuclear Information System (INIS)

    Herrmann, Michael; Rademacher, Jens D M

    2010-01-01

    We consider FPU-type atomic chains with general convex potentials. The naive continuum limit in the hyperbolic space–time scaling is the p-system of mass and momentum conservation. We systematically compare Riemann solutions to the p-system with numerical solutions to discrete Riemann problems in FPU chains, and argue that the latter can be described by modified p-system Riemann solvers. We allow the flux to have a turning point, and observe a third type of elementary wave (conservative shocks) in the atomistic simulations. These waves are heteroclinic travelling waves and correspond to non-classical, undercompressive shocks of the p-system. We analyse such shocks for fluxes with one or more turning points. Depending on the convexity properties of the flux we propose FPU-Riemann solvers. Our numerical simulations confirm that Lax shocks are replaced by so-called dispersive shocks. For convex–concave flux we provide numerical evidence that convex FPU chains follow the p-system in generating conservative shocks that are supersonic. For concave–convex flux, however, the conservative shocks of the p-system are subsonic and do not appear in FPU-Riemann solutions

  17. Systems, Shocks and Time Bombs

    Science.gov (United States)

    Winder, Nick

    The following sections are included: * Introduction * Modelling strategies * Are time-bomb phenomena important? * Heuristic approaches to time-bomb phenomena * Three rational approaches to TBP * Two irrational approaches * Conclusions * References

  18. 33 CFR 183.584 - Shock test.

    Science.gov (United States)

    2010-07-01

    ... SAFETY BOATS AND ASSOCIATED EQUIPMENT Fuel Systems Tests § 183.584 Shock test. A fuel tank is tested by... the boat, apply 1000 cycles of 25g vertical accelerations at a rate of 80 cycles or less per minute... manufactured for installation with its center of gravity aft of the half length of the boat, apply 1000 cycles...

  19. Heat Shock Protein 90 Inhibitor (17-AAG) Induces Apoptosis and Decreases Cell Migration/Motility of Keloid Fibroblasts.

    Science.gov (United States)

    Yun, In Sik; Lee, Mi Hee; Rah, Dong Kyun; Lew, Dae Hyun; Park, Jong-Chul; Lee, Won Jai

    2015-07-01

    The regulation of apoptosis, proliferation, and migration of fibroblasts is altered in keloids. The 90-kDa heat shock protein (heat shock protein 90) is known to play a key role in such regulation. Therefore, the authors investigated whether the inhibition of heat shock protein 90 in keloid fibroblasts could induce apoptosis and attenuate keloid fibroblast proliferation and migration. The authors evaluated heat shock protein 90 expression in keloid tissues with immunohistochemistry. The authors used cell viability [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assays and annexin V/propidium iodide staining for apoptosis, a wound healing model and cell tracking system to assess cell migration, and Akt Western blotting analysis in keloid fibroblasts after inhibition of heat shock protein 90 with 17-allylaminodemethoxygeldanamycin (17-AAG). The expression of heat shock protein 90 in keloid tissues was significantly increased compared with normal tissues. The 17-AAG-treated keloid fibroblasts showed significantly decreased proliferation, promotion of apoptosis, and decreased expression of Akt. Furthermore, a dose-dependent decrease in cell migration was noted after 17-AAG treatment of keloid fibroblasts. The 17-AAG-treated keloid fibroblasts had less directionality to the wound center and migrated a shorter distance. The authors confirmed that the inhibition of heat shock protein 90 in keloid fibroblasts could promote apoptosis and attenuate proliferation and migration of keloid fibroblasts. Therefore, the authors think that the inhibition of heat shock protein 90 is a key factor in the regulation of biological processes in keloids. With further preclinical study, the authors will be able to apply these results clinically for keloid treatment.

  20. Shock dynamics of weak imploding cylindrical and spherical shock waves with non-ideal gas effects

    International Nuclear Information System (INIS)

    Anand, R K

    2013-01-01

    The author (Anand 2012 Astrophys. Space Sci. 342 377–88) recently obtained jump relations across a shock front in non-ideal gas flow taking into consideration the equation of state for a non-ideal gas as given by Landau and Lifshitz. In this paper an analytical solution for one-dimensional adiabatic flow behind weak converging shock waves propagating in a non-ideal gas is obtained by using Whitham's (1974 Linear and Nonlinear Waves (New York: Wiley)) geometrical shock dynamics approach. The effects of an increase in (i) the propagation distance from the centre of convergence, (ii) the non-idealness parameter and (iii) the adiabatic index of the gas, on the shock velocity, pressure, density, particle velocity, adiabatic compressibility and the change in entropy across the shock front, are analyzed. The results provided a clear picture of whether and how the non-idealness parameter and the adiabatic index affect the flow field behind the imploding shock front. (paper)

  1. Thoracic CT findings at hypovolemic shock

    International Nuclear Information System (INIS)

    Rotondo, A.; Angelelli, G.; Catalano, O.; Grassi, R.; Scialpi, M.

    1998-01-01

    Purpose: To describe and discuss the thoracic CT features of hypovolemic shock. Material and Methods: From a group of 18 patients with signs of hypovolemia on contrast-enhanced abdominal CT, 11 were selected for our study as having also undergone a complete chest examination. Pulse rate, blood pressure, trauma score value, Glasgow coma scale value, surgical result, and final outcome were retrospectively evaluated. The CT features analyzed were: decreased cardiac volume, reduced caliber of the thoracic aorta, aortic branches and caval venous system, increased enhancement of the aorta, and increased enhancement of the pulmonary collapses/contusions. Results: All 11 subjects presented severe injuries and hemodynamic instability; 7 were stable enough to undergo surgery; only 1 of the 11 survived. Two patients showed none of the features of thoracic hypovolemia. All the other patients presented at least two signs: reduced caliber of the thoracic aorta in 7 cases; decreased volume of the cardiac chambers and increased aortic enhancement in 6; decreased caliber of the aortic vessels in 4; decreased caliber of the caval veins in 3; and increased enhancement of the pulmonary collapses/contusions in 3. Conclusions: In patients with hypovolemia, CT may show several thoracic findings in addition to abdominal ones. Knowledge of these features is important for distinguishing them from traumatic injuries. (orig.)

  2. Income Shocks and Adolescent Mental Health

    Science.gov (United States)

    Baird, Sarah; de Hoop, Jacobus; Ozler, Berk

    2013-01-01

    We investigate the effects of a positive income shock on mental health among adolescent girls using evidence from a cash transfer experiment in Malawi. Offers of cash transfers strongly reduced psychological distress among baseline schoolgirls. However, these large beneficial effects declined with increases in the transfer amount offered to the…

  3. Radiating shocks and condensations in flares

    International Nuclear Information System (INIS)

    Fisher, G.H.

    1985-01-01

    Rapid energy release (by either ''thick target'' (beam) or ''thermal'' models of heating) in solar flare loop models usually leads to ''chromospheric evaporation,'' the process of heating cool chromospheric material to coronal temperatures, and the resulting increase in hot soft x-ray emitting plasma. The evaporated plasma flows up into the coronal portion of the loop because of the increased pressure in the evaporated region. However, the pressure increase also leads to a number of interesting phenomena in the flare chromosphere, which will be the subject of this paper. The sudden pressure increase in the evaporated plasma initiates a downward moving ''chromospheric condensation,'' an overdense region which gradually decelerates as it accretes material and propagates into the gravitationally stratified chromosphere. Solutions to an equation of motion for this condensation shows that its motion decays after about one minute of propagation into the chromosphere. When the front of this downflowing region is supersonic relative to the atmosphere ahead of it, a radiating shock will form. If the downflow is rapid enough, the shock strength should be sufficient to excite uv radiation normally associated with the transition region, and furthermore, the radiating shock will be brighter than the transition region. These results lead to a number of observationally testable relationships between the optical and ultraviolet spectra from the condensation and radiating shock

  4. Bubble Dynamics and Shock Waves

    CERN Document Server

    2013-01-01

    This volume of the Shock Wave Science and Technology Reference Library is concerned with the interplay between bubble dynamics and shock waves. It is divided into four parts containing twelve chapters written by eminent scientists. Topics discussed include shock wave emission by laser generated bubbles (W Lauterborn, A Vogel), pulsating bubbles near boundaries (DM Leppinen, QX Wang, JR Blake), interaction of shock waves with bubble clouds (CD Ohl, SW Ohl), shock propagation in polydispersed bubbly liquids by model equations (K Ando, T Colonius, CE Brennen. T Yano, T Kanagawa,  M Watanabe, S Fujikawa) and by DNS (G Tryggvason, S Dabiri), shocks in cavitating flows (NA Adams, SJ Schmidt, CF Delale, GH Schnerr, S Pasinlioglu) together with applications involving encapsulated bubble dynamics in imaging (AA Doinikov, A Novell, JM Escoffre, A Bouakaz),  shock wave lithotripsy (P Zhong), sterilization of ships’ ballast water (A Abe, H Mimura) and bubbly flow model of volcano eruptions ((VK Kedrinskii, K Takayama...

  5. Microjetting from a grooved Al surface under supported and unsupported shocks

    Science.gov (United States)

    Shao, Jian-Li; Wang, Pei; He, An-Min

    2014-08-01

    Using molecular dynamics methods, we simulate and compare the microjetting from a grooved Al surface induced by supported and unsupported shocks at different breakout pressures. Via the analysis on the microjetting morphologies and mass distributions, we find that the threshold of shock breakout pressure for the microjetting formation is almost same, but the variation of microjet mass with shock pressure shows a great difference for the two loading patterns. Under supported shock loading, the microjet mass keeps a continuous increase with increasing shock pressure, and release melting can enhance it markedly. By contrast, the microjet mass under unsupported shocks is smaller and seems no remarkable increase with shock pressure in our simulations (at extremely short pulses), implying the shock decaying can weaken the microjetting. Of course, a large area of fragments near the surface may form in this case. The microjet source distributions corresponding to supported and unsupported shocks are presented. It is found that the former becomes apparently broader than the latter with increasing shock pressure. Besides, the microjet tip velocity under supported shocks may appear a reduction because of the material strength effect below release melting. While under unsupported shocks, all the microjets in solid and melted states will experience the reduction of tip velocity. These decrements of tip velocity can be fitted by an exponential function.

  6. Well-Being Analysis of Power Systems Considering Increasing Deployment of Gas Turbines

    Directory of Open Access Journals (Sweden)

    Bomiao Liang

    2017-07-01

    Full Text Available With the significant decrease in natural gas prices in many parts of the world, the employment of gas turbine (GT units has increased steadily in recent years. The ever-increasing deployment of GT units is strengthening the interconnections between electric power and natural gas systems, which could provide a higher level of operational flexibility and reliability. As a result, the planning and operation issues in the interconnected electric power and natural gas systems have aroused concern. In these circumstances, the impacts of increasing deployment of GT units in power system operation are studied and evaluated through well-being analysis (WBA. The fast responsive characteristics of GT units are analyzed first, and the definition and adaption of WBA in a power system with increasing deployment of GT units are addressed. Then the equivalent reserve capacity of GT units is estimated, taking demand fluctuations, commitment plans, and operational risks of GT units into account. The WBA of a power system with increasing deployment of GT units is conducted considering the uncertainties of system operation states and renewable energy sources. Finally, the proposed methods are validated through an integrated version of the IEEE 118-bus power system and a 10-bus natural gas system, and the impacts of GT units on power system security under various penetration levels are examined. Simulation results demonstrate that the role of a GT unit as a low-cost electricity producer may conflict with its role as a reserve provider, but through maintaining a proper proportion of idle GT capacities for reserve, the well-being performance of the power system concerned can be significantly improved.

  7. Tandem shock wave cavitation enhancement for extracorporeal lithotripsy

    Science.gov (United States)

    Loske, Achim M.; Prieto, Fernando E.; Fernández, Francisco; van Cauwelaert, Javier

    2002-11-01

    Extracorporeal shock wave lithotripsy (ESWL) has been successful for more than twenty years in treating patients with kidney stones. Hundreds of underwater shock waves are generated outside the patient's body and focused on the kidney stone. Stones fracture mainly due to spalling, cavitation and layer separation. Cavitation bubbles are produced in the vicinity of the stone by the tensile phase of each shock wave. Bubbles expand, stabilize and finally collapse violently, creating stone-damaging secondary shock waves and microjets. Bubble collapse can be intensified by sending a second shock wave a few hundred microseconds after the first. A novel method of generating two piezoelectrically generated shock waves with an adjustable time delay between 50 and 950 µs is described and tested. The objective is to enhance cavitation-induced damage to kidney stones during ESWL in order to reduce treatment time. In vitro kidney stone model fragmentation efficiency and pressure measurements were compared with those for a standard ESWL system. Results indicate that fragmentation efficiency was significantly enhanced at a shock wave delay of about 400 and 250 µs using rectangular and spherical stone phantoms, respectively. The system presented here could be installed in clinical devices at relatively low cost, without the need for a second shock wave generator.

  8. The interactive association between heat shock factor 1 and heat shock proteins in primary myocardial cells subjected to heat stress.

    Science.gov (United States)

    Tang, Shu; Chen, Hongbo; Cheng, Yanfen; Nasir, Mohammad Abdel; Kemper, Nicole; Bao, Endong

    2016-01-01

    Heat shock factor 1 (HSF1) is a heat shock transcription factor that rapidly induces heat shock gene transcription following thermal stress. In this study, we subjected primary neonatal rat myocardial cells to heat stress in vitro to create a model system for investigating the trends in expression and association between various heat shock proteins (HSPs) and HSF1 under adverse environmental conditions. After the cells were subjected to heat stress at 42˚C for different periods of time, HSP and HSF1 mRNA and protein levels were detected by qPCR and western blot analysis in the heat-stressed cells. The HSF1 expression levels significantly increased in the cells following 120 min of exposure to heat stess compared to the levels observed at the beginning of heat stress exposure. HSP90 followed a similar trend in expression to HSF1, whereas HSP70 followed an opposite trend. However, no significant changes were observed in the crystallin, alpha B (CRYAB, also known as HSP beta-5) expression levels during the 480‑min period of exposure to heat stress. The interaction between the HSPs and HSF1 was analyzed by STRING 9.1, and it was found that HSF1 interacted with HSP90 and HSP70, and that it did not play a role in regulating CRYAB expression. Based on our findings, HSP70 may suppress HSF1 in rat myocardial cells under conditions of heat stress. Furthermore, our data demonstrate that HSF1 is not the key factor for all HSPs, and this was particularly the case for CRYAB.

  9. Time Series Analysis of Wheat flour Price Shocks in Pakistan: A Case Analysis

    OpenAIRE

    Asad Raza Abdi; Ali Hassan Halepoto; Aisha Bashir Shah; Faiz M. Shaikh

    2013-01-01

    The current research investigates the wheat flour Price Shocks in Pakistan: A case analysis. Data was collected by using secondary sources by using Time series Analysis, and data were analyzed by using SPSS-20 version. It was revealed that the price of wheat flour increases from last four decades, and trend of price shocks shows that due to certain market variation and supply and demand shocks also play a positive relationship in price shocks in the wheat prices. It was further revealed th...

  10. Two-stream instability in collisionless shocks and foreshock

    International Nuclear Information System (INIS)

    Dieckmann, M E; Eliasson, B; Shukla, P K; Sircombe, N J; Dendy, R O

    2006-01-01

    Shocks play a key role in plasma thermalization and particle acceleration in the near Earth space plasma, in astrophysical plasma and in laser plasma interactions. An accurate understanding of the physics of plasma shocks is thus of immense importance. We give an overview over some recent developments in particle-in-cell simulations of plasma shocks and foreshock dynamics. We focus on ion reflection by shocks and on the two-stream instabilities these beams can drive, and these are placed in the context of experimental observations, e.g. by the Cluster mission. We discuss how we may expand the insight gained from the observation of proton beam driven instabilities at near Earth plasma shocks to better understand their astrophysical counterparts, such as ion beam instabilities triggered by internal and external shocks in the relativistic jets of gamma ray bursts, shocks in the accretion discs of micro-quasars and supernova remnant shocks. It is discussed how and why the peak energy that can be reached by particles that are accelerated by two-stream instabilities increases from keV energies to GeV energies and beyond, as we increase the streaming speed to relativistic values, and why the particle energy spectrum sometimes resembles power law distributions

  11. Two-stream instability in collisionless shocks and foreshock

    Energy Technology Data Exchange (ETDEWEB)

    Dieckmann, M E [Institute of Theoretical Physics IV and Centre for Plasma Science and Astrophysics, Ruhr-University Bochum, D-44780 Bochum (Germany); Eliasson, B [Institute of Theoretical Physics IV and Centre for Plasma Science and Astrophysics, Ruhr-University Bochum, D-44780 Bochum (Germany); Shukla, P K [Institute of Theoretical Physics IV and Centre for Plasma Science and Astrophysics, Ruhr-University Bochum, D-44780 Bochum (Germany); Sircombe, N J [Centre for Fusion, Space and Astrophysics, Department of Physics, Warwick University, Coventry CV4 7AL (United Kingdom); Dendy, R O [Centre for Fusion, Space and Astrophysics, Department of Physics, Warwick University, Coventry CV4 7AL (United Kingdom)

    2006-12-15

    Shocks play a key role in plasma thermalization and particle acceleration in the near Earth space plasma, in astrophysical plasma and in laser plasma interactions. An accurate understanding of the physics of plasma shocks is thus of immense importance. We give an overview over some recent developments in particle-in-cell simulations of plasma shocks and foreshock dynamics. We focus on ion reflection by shocks and on the two-stream instabilities these beams can drive, and these are placed in the context of experimental observations, e.g. by the Cluster mission. We discuss how we may expand the insight gained from the observation of proton beam driven instabilities at near Earth plasma shocks to better understand their astrophysical counterparts, such as ion beam instabilities triggered by internal and external shocks in the relativistic jets of gamma ray bursts, shocks in the accretion discs of micro-quasars and supernova remnant shocks. It is discussed how and why the peak energy that can be reached by particles that are accelerated by two-stream instabilities increases from keV energies to GeV energies and beyond, as we increase the streaming speed to relativistic values, and why the particle energy spectrum sometimes resembles power law distributions.

  12. Modeling multiscale evolution of numerous voids in shocked brittle material.

    Science.gov (United States)

    Yu, Yin; Wang, Wenqiang; He, Hongliang; Lu, Tiecheng

    2014-04-01

    The influence of the evolution of numerous voids on macroscopic properties of materials is a multiscale problem that challenges computational research. A shock-wave compression model for brittle material, which can obtain both microscopic evolution and macroscopic shock properties, was developed using discrete element methods (lattice model). Using a model interaction-parameter-mapping procedure, qualitative features, as well as trends in the calculated shock-wave profiles, are shown to agree with experimental results. The shock wave splits into an elastic wave and a deformation wave in porous brittle materials, indicating significant shock plasticity. Void collapses in the deformation wave were the natural reason for volume shrinkage and deformation. However, media slippage and rotation deformations indicated by complex vortex patterns composed of relative velocity vectors were also confirmed as an important source of shock plasticity. With increasing pressure, the contribution from slippage deformation to the final plastic strain increased. Porosity was found to determine the amplitude of the elastic wave; porosity and shock stress together determine propagation speed of the deformation wave, as well as stress and strain on the final equilibrium state. Thus, shock behaviors of porous brittle material can be systematically designed for specific applications.

  13. Density Effects on Post-shock Turbulence Structure

    Science.gov (United States)

    Tian, Yifeng; Jaberi, Farhad; Livescu, Daniel; Li, Zhaorui; Michigan State University Collaboration; Los Alamos National Laboratory Collaboration; Texas A&M University-Corpus Christi Collaboration

    2017-11-01

    The effects of density variations due to mixture composition on post-shock turbulence structure are studied using turbulence-resolving shock-capturing simulations. This work extends the canonical Shock-Turbulence Interaction (STI) problem to involve significant variable density effects. The numerical method has been verified using a series of grid and LIA convergence tests, and is used to generate accurate post-shock turbulence data for a detailed flow study. Density effects on post-shock turbulent statistics are shown to be significant, leading to an increased amplification of turbulent kinetic energy (TKE). Eulerian and Lagrangian analyses show that the increase in the post-shock correlation between rotation and strain is weakened in the case with significant density variations (referred to as the ``multi-fluid'' case). Similar to previous single-fluid results and LIA predictions, the shock wave significantly changes the topology of the turbulent structures, exhibiting a symmetrization of the joint PDF of second and third invariant of the deviatoric part of velocity gradient tensor. In the multi-fluid case, this trend is more significant and mainly manifested in the heavy fluid regions. Lagrangian data are also used to study the evolution of turbulence structure away from the shock wave and assess the accuracy of Lagrangian dynamical models.

  14. Learning Management System Success: Increasing Learning Management System Usage in Higher Education in Sub-Saharan Africa

    Science.gov (United States)

    Mtebe, Joel S.

    2015-01-01

    Learning Management Systems (LMS) have been widely adopted by higher education institutions globally for over a decade. Institutions in sub-Saharan Africa now spend a significant proportion of their limited resources on installing and maintaining these systems. This expenditure continues to increase, raising questions as to whether LMS in these…

  15. Hydrophobic interaction chromatography in dual salt system increases protein binding capacity.

    Science.gov (United States)

    Senczuk, Anna M; Klinke, Ralph; Arakawa, Tsutomu; Vedantham, Ganesh; Yigzaw, Yinges

    2009-08-01

    Hydrophobic interaction chromatography (HIC) uses weakly hydrophobic resins and requires a salting-out salt to promote protein-resin interaction. The salting-out effects increase with protein and salt concentration. Dynamic binding capacity (DBC) is dependent on the binding constant, as well as on the flow characteristics during sample loading. DBC increases with the salt concentration but decreases with increasing flow rate. Dynamic and operational binding capacity have a major raw material cost/processing time impact on commercial scale production of monoclonal antibodies. In order to maximize DBC the highest salt concentration without causing precipitation is used. We report here a novel method to maintain protein solubility while increasing the DBC by using a combination of two salting-out salts (referred to as dual salt). In a series of experiments, we explored the dynamic capacity of a HIC resin (TosoBioscience Butyl 650M) with combinations of salts. Using a model antibody, we developed a system allowing us to increase the dynamic capacity up to twofold using the dual salt system over traditional, single salt system. We also investigated the application of this novel approach to several other proteins and salt combinations, and noted a similar protein solubility and DBC increase. The observed increase in DBC in the dual salt system was maintained at different linear flow rates and did not impact selectivity.

  16. The Role of Control System in Increasing Corporate social Performance: The Use of Levers of Control

    Directory of Open Access Journals (Sweden)

    Hasan Fauzi

    2008-06-01

    Full Text Available One important instrument to be used in the control system design is strategic behaviors that can lead to the expected organization performance.  Referring to the extended definition of strategic behavior using stakeholder-based strategic behavior, corporate social performance is kind of strategic behavior to be influenced by using control system. This paper discusses how control system, using Simons‟ levers of control can play important role in increasing the corporate social performance. The interaction between control system, including belief system, boundary system, diagnostic control system, and interactive control system, as well as the corporate financial performance (CFP can affect the corporate social performance (CSP due to fact that increase in CFP resulting from the appropriate use of control system components enables the company has more chance to do the CSP. The levers of control are deemed to form an integral part of employee socialization and support the development of an organization‟s culture, the system of shared beliefs, values, norms, and mores of organizational members which are deemed to be a primary determinant of the direction of employee behavior.

  17. Hybrid PV/wind system with quinary asymmetric inverter without increasing DC-link number

    Directory of Open Access Journals (Sweden)

    Aida Baghbany Oskouei

    2016-06-01

    Full Text Available This paper suggests quinary asymmetric inverter with coupled inductors and transformer, and uses it in hybrid system including photovoltaic (PV and wind. This inverter produces twenty-five-level voltage in addition to merits of multilevel inverter, has only one DC source. Then, it is adequate for hybrid systems, which prevents increasing DC-link and makes control of system easy. Proposed structure also provides isolation in the system and the switch numbers are reduced in this topology compared with other multilevel structures. In this system, battery is used as backup, where PV and wind have complementary nature. The performance of proposed inverter and hybrid system is validated with simulation results using MATLAB/SIMULINK software and experimental results based PCI-1716 data acquisition system.

  18. Radiative relativistic shock adiabate

    International Nuclear Information System (INIS)

    Tsintsadze, L.N.; Nishikawa, K.

    1997-01-01

    The influences of thermal radiation on the state equation of shock waves, derived in the previous paper [L. N. Tsintsadze, Phys. Plasmas 2, 4462 (1995)], are studied and a series of relations of thermodynamic quantities that hold for shock waves are derived. It is shown that the presence of radiation can strongly change the compressibility of the plasma. It is well known that for polytropic gases the compressibility cannot change more than four times the initial value in the case of nonrelativistic temperatures. The numerical calculations show that there are no such restrictions, when the radiation energy exceeds the kinetic energy of the plasma. The ultrarelativistic temperature range is also covered in our numerical calculations. Also studied are the influences of the radiation on the PT and the TV diagrams. A significant modification due to radiation is found in every case studied. copyright 1997 American Institute of Physics

  19. POSTURAL SHOCK IN PREGNANCY

    Science.gov (United States)

    Wilkening, Ralph L.; Knauer, John; Larson, Roger K.

    1955-01-01

    Signs and symptoms of shock may be produced in some patients in late pregnancy by putting them in the dorsal recumbent posture. Change from this position will relieve the condition. The features of the supine hypotensive syndrome can be duplicated by applying pressure to the abdomen with the patient in a lateral position. The postural variations of venous pressure, blood pressure, and pulse appear to be due to obstruction of venous return from the lower portion of the body caused by the large uterus of late pregnancy compressing the vena cava. When shock is observed in a woman in late pregnancy, she should be turned to a lateral position before more active measures of treatment are begun. ImagesFigure 1. PMID:14351983

  20. Bow shock data analysis

    Science.gov (United States)

    Zipf, Edward C.; Erdman, Peeter W.

    1994-08-01

    The University of Pittsburgh Space Physics Group in collaboration with the Army Research Office (ARO) modeling team has completed a systematic organization of the shock and plume spectral data and the electron temperature and density measurements obtained during the BowShock I and II rocket flights which have been submitted to the AEDC Data Center, has verified the presence of CO Cameron band emission during the Antares engine burn and for an extended period of time in the post-burn plume, and have adapted 3-D radiation entrapment codes developed by the University of Pittsburgh to study aurora and other atmospheric phenomena that involve significant spatial effects to investigate the vacuum ultraviolet (VUV) and extreme ultraviolet (EUV) envelope surrounding the re-entry that create an extensive plasma cloud by photoionization.

  1. Shock Isolation Elements Testing for High Input Loadings. Volume III. Mechanical Shock Isolation Elements.

    Science.gov (United States)

    SHOCK ABSORBERS ), (*GUIDED MISSILE SILOS, SHOCK ABSORBERS ), (*SPRINGS, (*SHOCK(MECHANICS), REDUCTION), TORSION BARS, ELASTOMERS, DAMPING, EQUATIONS OF MOTION, MODEL TESTS, TEST METHODS, NUCLEAR EXPLOSIONS, HARDENING.

  2. Shock resistance testing

    International Nuclear Information System (INIS)

    Pouard, M.

    1984-03-01

    In the framework of mechanical tests and to answer the different requests for tests, the T.C.R (Transport Conditionnement et Retraitement) laboratory got test facilities. These installations allow to carry out tests of resistance to shocks, mainly at the safety level of components of nuclear power plants, mockups of transport casks for fuel elements and transport containers for radioactive materials. They include a tower and a catapult. This paper give a decription of the facilities and explain their operation way [fr

  3. On Modeling Risk Shocks

    OpenAIRE

    Dorofeenko, Victor; Lee, Gabriel; Salyer, Kevin; Strobel, Johannes

    2016-01-01

    Within the context of a financial accelerator model, we model time-varying uncertainty (i.e. risk shocks) through the use of a mixture Normal model with time variation in the weights applied to the underlying distributions characterizing entrepreneur productivity. Specifically, we model capital producers (i.e. the entrepreneurs) as either low-risk (relatively small second moment for productivity) and high-risk (relatively large second moment for productivity) and the fraction of both types is...

  4. The Shock Doctrine

    OpenAIRE

    Dionysios K. Solomos; Dimitrios N. Koumparoulis

    2011-01-01

    Naomi Klein attempts to redefine the economic history discovering the historical continuities and to reveal the neoliberal theory which functions via the utilization of specific “tools”. The state of shock is the key for the opponents of Chicago School and Milton Friedman in order for them to establish neoliberal policies and to promote the deregulated capitalism which includes less welfare state, less public sector, less regulation, weakened labor unions, privatizations and laissez-faire. Th...

  5. Theory of the shock process in dense fluids

    International Nuclear Information System (INIS)

    Wallace, D.C.

    1991-01-01

    A shock is assumed to be a steady plane wave, and irreversible thermodynamics is assumed valid. The fluid is characterized by heat conduction and by viscous or viscoelastic response, according to the strain rate. It is shown that setting the viscosity zero produces a solution which constitutes a lower bound through the shock process for the shear stress, and upper bounds for the temperature, entropy, pressure, and heat current. It is shown that there exists an upper bound to the dynamic stresses which can be achieved during shock compression, that this bound corresponds to a purely elastic response of the fluid, and that solution for the shock process along this bound constitutes lower bounds for the temperature and entropy. It is shown that a continuous steady shock is possible only if the heat current is positive and the temperature is an increasing function of compression almost everywhere. In his theory of shocks in gases, Rayleigh showed that there is a maximum shock strength for which a continuous steady solution can exist with heat conduction but without viscosity. Two more limits are shown to exist for dense fluids, based on the fluid response in the leading edge of the shock: for shocks at the overdriven threshold and above, no solution is possible without heat transport; for shocks near the viscous fluid limit and above, viscous fluid theory is not valid, and the fluid response in the leading edge of the shock is approximately that of a nonplastic solid. The viscous fluid limit is estimated to be 13 kbar for water and 690 kbar for mercury

  6. Characterization of shocked beryllium

    Directory of Open Access Journals (Sweden)

    Papin P.A.

    2012-08-01

    Full Text Available While numerous studies have investigated the low-strain-rate constitutive response of beryllium, the combined influence of high strain rate and temperature on the mechanical behavior and microstructure of beryllium has received limited attention over the last 40 years. In the current work, high strain rate tests were conducted using both explosive drive and a gas gun to accelerate the material. Prior studies have focused on tensile loading behavior, or limited conditions of dynamic strain rate and/or temperature. Two constitutive strength (plasticity models, the Preston-Tonks-Wallace (PTW and Mechanical Threshold Stress (MTS models, were calibrated using common quasi-static and Hopkinson bar data. However, simulations with the two models give noticeably different results when compared with the measured experimental wave profiles. The experimental results indicate that, even if fractured by the initial shock loading, the Be remains sufficiently intact to support a shear stress following partial release and subsequent shock re-loading. Additional “arrested” drive shots were designed and tested to minimize the reflected tensile pulse in the sample. These tests were done to both validate the model and to put large shock induced compressive loads into the beryllium sample.

  7. The use of SVAR analysis in determining the effects of fiscal shocks in Croatia

    Directory of Open Access Journals (Sweden)

    Raafel Ravnik

    2011-03-01

    Full Text Available In this paper we use multivariate Blanchard-Perotti SVAR methodology to analyze disaggregated short-term effects of fiscal policy on economic activity, inflation and short-term interest rates. The results suggest that the effects of government expenditure shocks and the shock of government revenues are relatively the highest on interest rates and the lowest on inflation. A tax shock in the short term increases the inflation rate and also decreases the short-term interest rate, and after one year stabilization occurs at the initial level, while spending shock leads to a reverse effect. The effects of fiscal policies on the proxy variable of output, i.e. industrial production, are less economically intuitive, because the shock of expenditure decreases and revenue shock permanently increases industrial production. The empirical result shows that a tax shock has a permanent effect on future taxes; while future levels of government spending are not related to current expenditure shocks. Interactions between the components of fiscal policy are also examined and it is concluded that a tax shock increases expenditures permanently, while an expenditure shock does not significantly affect government revenues, which is consistent with the tendency of growth in public debt. Furthermore, it was found that government revenue and expenditure shocks do not have a mirror effect, which justifies disaggregated analysis of fiscal policy shocks.

  8. A coherency-based method to increase dynamic security in power systems

    Energy Technology Data Exchange (ETDEWEB)

    De Tuglie, E. [Dipartimento di Ingegneria dell' Ambiente e per lo Sviluppo Sostenibile - DIASS, Politecnico di Bari, Viale del Turismo 8, 74100 Taranto (Italy); Iannone, S.M.; Torelli, F. [Dipartimento di Elettrotecnica ed Elettronica - DEE, Politecnico di Bari, Via Re David 200, 70125 Bari (Italy)

    2008-08-15

    Dynamic security analysis is the evaluation of the ability of a system to withstand contingencies by surviving transient conditions to acceptable steady-state operative states. When potential instability due to contingency is detected, preventive action may be desired to improve the system security. This is very important in the on-line operation of a power system, especially when the system is stability-limited. The method proposed in this paper is based on the idea that increasing coherency between generators in the transient behaviour following a system perturbation gives rise to a more stable system. In this paper, we suggest the use of the ''input-output feedback-linearization'' with a reference trajectory obtained using a system dynamic equivalent based on the centre of inertia. To quantify coherency levels a new coherency indicator has been assumed for the given reference trajectory. The result is an increasing level in coherency, critical clearing time and system stability. The method is tested on the IEEE 30 bus test system. (author)

  9. Planar shock focusing through perfect gas lens: First experimental demonstration

    International Nuclear Information System (INIS)

    Biamino, Laurent; Mariani, Christian; Jourdan, Georges; Houas, Lazhar; Vandenboomgaerde, Marc; Souffland, Denis

    2014-01-01

    in the converging part has a circular shape. Moreover, pressure histories that were recorded during the experiments show pressure increase behind the accelerating converging shock wave. (authors)

  10. Curved Radio Spectra of Weak Cluster Shocks

    Science.gov (United States)

    Kang, Hyesung; Ryu, Dongsu

    2015-08-01

    In order to understand certain observed features of arc-like giant radio relics such as the rareness, uniform surface brightness, and curved integrated spectra, we explore a diffusive shock acceleration (DSA) model for radio relics in which a spherical shock impinges on a magnetized cloud containing fossil relativistic electrons. Toward this end, we perform DSA simulations of spherical shocks with the parameters relevant for the Sausage radio relic in cluster CIZA J2242.8+5301, and calculate the ensuing radio synchrotron emission from re-accelerated electrons. Three types of fossil electron populations are considered: a delta-function like population with the shock injection momentum, a power-law distribution, and a power law with an exponential cutoff. The surface brightness profile of the radio-emitting postshock region and the volume-integrated radio spectrum are calculated and compared with observations. We find that the observed width of the Sausage relic can be explained reasonably well by shocks with speed {u}{{s}}˜ 3× {10}3 {km} {{{s}}}-1 and sonic Mach number {M}{{s}}˜ 3. These shocks produce curved radio spectra that steepen gradually over (0.1-10){ν }{br} with a break frequency {ν }{br}˜ 1 GHz if the duration of electron acceleration is ˜60-80 Myr. However, the abrupt increase in the spectral index above ˜1.5 GHz observed in the Sausage relic seems to indicate that additional physical processes, other than radiative losses, operate for electrons with {γ }{{e}}≳ {10}4.

  11. Shock timing technique for the National Ignition Facility

    International Nuclear Information System (INIS)

    Munro, David H.; Celliers, Peter M.; Collins, Gilbert W.; Gold, David M.; Silva, Luiz B. da; Haan, Steven W.; Cauble, Robert C.; Hammel, Bruce A.; Hsing, Warren W.

    2001-01-01

    Among the final shots at the Nova laser [Campbell et al., Rev. Sci. Instrum. 57, 2101 (1986)] was a series testing the VISAR (velocity interferometry system for any reflector) technique that will be the primary diagnostic for timing the shocks in a NIF (National Ignition Facility) ignition capsule. At Nova, the VISAR technique worked over the range of shock strengths and with the precision required for the NIF shock timing job--shock velocities in liquid D 2 from 12 to 65 μm/ns with better than 2% accuracy. VISAR images showed stronger shocks overtaking weaker ones, which is the basis of the plan for setting the pulse shape for the NIF ignition campaign. The technique is so precise that VISAR measurements may also play a role in certifying beam-to-beam and shot-to-shot repeatability of NIF laser pulses

  12. Plasma and energetic particle structure upstream of a quasi-parallel interplanetary shock

    Science.gov (United States)

    Kennel, C. F.; Scarf, F. L.; Coroniti, F. V.; Russell, C. T.; Wenzel, K.-P.; Sanderson, T. R.; Van Nes, P.; Smith, E. J.; Tsurutani, B. T.; Scudder, J. D.

    1984-01-01

    ISEE 1, 2 and 3 data from 1978 on interplanetary magnetic fields, shock waves and particle energetics are examined to characterize a quasi-parallel shock. The intense shock studied exhibited a 640 km/sec velocity. The data covered 1-147 keV protons and electrons and ions with energies exceeding 30 keV in regions both upstream and downstream of the shock, and also the magnitudes of ion-acoustic and MHD waves. The energetic particles and MHD waves began being detected 5 hr before the shock. Intense halo electron fluxes appeared ahead of the shock. A closed magnetic field structure was produced with a front end 700 earth radii from the shock. The energetic protons were cut off from the interior of the magnetic bubble, which contained a markedly increased density of 2-6 keV protons as well as the shock itself.

  13. Intense laser driven collision-less shock and ion acceleration in magnetized plasmas

    Science.gov (United States)

    Mima, K.; Jia, Q.; Cai, H. B.; Taguchi, T.; Nagatomo, H.; Sanz, J. R.; Honrubia, J.

    2016-05-01

    The generation of strong magnetic field with a laser driven coil has been demonstrated by many experiments. It is applicable to the magnetized fast ignition (MFI), the collision-less shock in the astrophysics and the ion shock acceleration. In this paper, the longitudinal magnetic field effect on the shock wave driven by the radiation pressure of an intense short pulse laser is investigated by theory and simulations. The transition of a laminar shock (electro static shock) to the turbulent shock (electromagnetic shock) occurs, when the external magnetic field is applied in near relativistic cut-off density plasmas. This transition leads to the enhancement of conversion of the laser energy into high energy ions. The enhancement of the conversion efficiency is important for the ion driven fast ignition and the laser driven neutron source. It is found that the total number of ions reflected by the shock increases by six time when the magnetic field is applied.

  14. Hepatic Shock Differential Diagnosis and Risk Factors: A Review Article.

    Science.gov (United States)

    Soleimanpour, Hassan; Safari, Saeid; Rahmani, Farzad; Nejabatian, Arezu; Alavian, Seyed Moayed

    2015-10-01

    Liver as an important organ has a vital role in physiological processes in the body. Different causes can disrupt normal function of liver. Factors such as hypo-perfusion, hypoxemia, infections and some others can cause hepatic injury and hepatic shock. Published research resources from 2002 to May 2015 in some databases (PubMed, Scopus, Index Copernicus, DOAJ, EBSCO-CINAHL, Science direct, Cochrane library and Google scholar and Iranian search database like SID and Iranmedex) were investigated for the present study. Different causes can lead to hepatic shock. Most of these causes can be prevented by early resuscitation and treatment of underlying factors. Hepatic shock is detected in ill patients, especially those with hemodynamic disorders. It can be prevented by early treatment of underlying disease. There is no definite treatment for hepatic shock and should be managed conservatively. Hepatic shock in patients can increase the mortality rate.

  15. The characteristic response of whistler mode waves to interplanetary shocks

    Science.gov (United States)

    Yue, C.; Chen, L.; Bortnik, J.; Ma, Q.; Thorne, R. M.; Angelopoulos, V.; Li, J.; An, X.; Zhou, C.

    2017-12-01

    Magnetospheric whistler mode waves play a key role in regulating the dynamics of the electron radiation belts. Recent satellite observations indicate a significant influence of interplanetary (IP) shocks on whistler mode wave power in the inner magnetosphere. In this study, we statistically investigate the response of whistler mode chorus and plasmaspheric hiss to IP shocks based on Van Allen Probes and THEMIS satellite observations. Immediately after the IP shock arrival, chorus wave power is usually intensified, often at dawn, while plasmaspheric hiss wave power predominantly decreases near the dayside but intensifies near the nightside. We conclude that chorus wave intensification outside the plasmasphere is probably associated with the suprathermal electron flux enhancement caused by the IP shock. On the other hand, the solar wind dynamic pressure increase changes the magnetic field configuration to favor ray penetration into the nightside and promote ray refraction away from the dayside, explaining the magnetic local time (MLT) dependent responses of plasmaspheric hiss waves following IP shock arrivals.

  16. Relationships between oil price shocks and stock market: An empirical analysis from China

    International Nuclear Information System (INIS)

    Cong Ronggang; Wei Yiming; Jiao Jianlin; Fan Ying

    2008-01-01

    This paper investigates the interactive relationships between oil price shocks and Chinese stock market using multivariate vector auto-regression. Oil price shocks do not show statistically significant impact on the real stock returns of most Chinese stock market indices, except for manufacturing index and some oil companies. Some 'important' oil price shocks depress oil company stock prices. Increase in oil volatility may increase the speculations in mining index and petrochemicals index, which raise their stock returns. Both the world oil price shocks and China oil price shocks can explain much more than interest rates for manufacturing index

  17. Relationships between oil price shocks and stock market: An empirical analysis from China

    DEFF Research Database (Denmark)

    Cong, Ronggang; Wei, Yi-Ming; Jiao, Jian-Ling

    2008-01-01

    This paper investigates the interactive relationships between oil price shocks and Chinese stock market using multivariate vector auto-regression. Oil price shocks do not show statistically significant impact on the real stock returns of most Chinese stock market indices, except for manufacturing...... index and some oil companies. Some “important” oil price shocks depress oil company stock prices. Increase in oil volatility may increase the speculations in mining index and petrochemicals index, which raise their stock returns. Both the world oil price shocks and China oil price shocks can explain...

  18. Using an integrated automated system to optimize retention and increase frequency of blood donations.

    Science.gov (United States)

    Whitney, J Garrett; Hall, Robert F

    2010-07-01

    This study examines the impact of an integrated, automated phone system to reinforce retention and increase frequency of donations among blood donors. Cultivated by incorporating data results over the past 7 years, the system uses computerized phone messaging to contact blood donors with individualized, multilevel notifications. Donors are contacted at planned intervals to acknowledge and recognize their donations, informed where their blood was sent, asked to participate in a survey, and reminded when they are eligible to donate again. The report statistically evaluates the impact of the various components of the system on donor retention and blood donations and quantifies the fiscal advantages to blood centers. By using information and support systems provided by the automated services and then incorporating the phlebotomists and recruiters to reinforce donor retention, both retention and donations will increase. © 2010 American Association of Blood Banks.

  19. International Shock-Wave Database: Current Status

    Science.gov (United States)

    Levashov, Pavel

    2013-06-01

    Shock-wave and related dynamic material response data serve for calibrating, validating, and improving material models over very broad regions of the pressure-temperature-density phase space. Since the middle of the 20th century vast amount of shock-wave experimental information has been obtained. To systemize it a number of compendiums of shock-wave data has been issued by LLNL, LANL (USA), CEA (France), IPCP and VNIIEF (Russia). In mid-90th the drawbacks of the paper handbooks became obvious, so the first version of the online shock-wave database appeared in 1997 (http://www.ficp.ac.ru/rusbank). It includes approximately 20000 experimental points on shock compression, adiabatic expansion, measurements of sound velocity behind the shock front and free-surface-velocity for more than 650 substances. This is still a useful tool for the shock-wave community, but it has a number of serious disadvantages which can't be easily eliminated: (i) very simple data format for points and references; (ii) minimalistic user interface for data addition; (iii) absence of history of changes; (iv) bad feedback from users. The new International Shock-Wave database (ISWdb) is intended to solve these and some other problems. The ISWdb project objectives are: (i) to develop a database on thermodynamic and mechanical properties of materials under conditions of shock-wave and other dynamic loadings, selected related quantities of interest, and the meta-data that describes the provenance of the measurements and material models; and (ii) to make this database available internationally through the Internet, in an interactive form. The development and operation of the ISWdb is guided by an advisory committee. The database will be installed on two mirrored web-servers, one in Russia and the other in USA (currently only one server is available). The database provides access to original experimental data on shock compression, non-shock dynamic loadings, isentropic expansion, measurements of sound

  20. ViewBricks: a participatory system to increase social connectedness for the elderly in care homes

    OpenAIRE

    Lin, X.; Kang, K.; Li, C.; Hu, J.; Hengeveld, B.; Rauterberg, M.; Hummels, C.

    2016-01-01

    Driven by the maturing of Internet and the development of the Internet of Things, people are becoming connected not only via the smart personal devices, but also via the increasingly responsive and connected environments, which brings up new opportunities to involve potential user group like elderly people into this network through tangible interaction and embedded systems. This paper presents the design and implementation of a participatory view-sharing system which consists of a group of sp...

  1. The role of artificial intelligence and expert systems in increasing STS operations productivity

    Science.gov (United States)

    Culbert, C.

    1985-01-01

    Artificial Intelligence (AI) is discussed. A number of the computer technologies pioneered in the AI world can make significant contributions to increasing STS operations productivity. Application of expert systems, natural language, speech recognition, and other key technologies can reduce manpower while raising productivity. Many aspects of STS support lend themselves to this type of automation. The artificial intelligence section of the mission planning and analysis division has developed a number of functioning prototype systems which demonstrate the potential gains of applying AI technology.

  2. Acceleration of cosmic rays in SNR shock waves

    International Nuclear Information System (INIS)

    Drury, L.O'C.; Markiewicz, W.J.; Voelk, H.J.

    1988-01-01

    The time dependence of the energy density of cosmic rays accelerated in the outer shock of a supernova is studied in simple nonlinear models. The solutions are classified in their dependence on the parameters of the system. (orig.)

  3. Bacterial survival following shock compression in the GigaPascal range

    Science.gov (United States)

    Hazael, Rachael; Fitzmaurice, Brianna C.; Foglia, Fabrizia; Appleby-Thomas, Gareth J.; McMillan, Paul F.

    2017-09-01

    The possibility that life can exist within previously unconsidered habitats is causing us to expand our understanding of potential planetary biospheres. Significant populations of living organisms have been identified at depths extending up to several km below the Earth's surface; whereas laboratory experiments have shown that microbial species can survive following exposure to GigaPascal (GPa) pressures. Understanding the degree to which simple organisms such as microbes survive such extreme pressurization under static compression conditions is being actively investigated. The survival of bacteria under dynamic shock compression is also of interest. Such studies are being partly driven to test the hypothesis of potential transport of biological organisms between planetary systems. Shock compression is also of interest for the potential modification and sterilization of foodstuffs and agricultural products. Here we report the survival of Shewanella oneidensis bacteria exposed to dynamic (shock) compression. The samples examined included: (a) a "wild type" (WT) strain and (b) a "pressure adapted" (PA) population obtained by culturing survivors from static compression experiments to 750 MPa. Following exposure to peak shock pressures of 1.5 and 2.5 GPa the proportion of survivors was established as the number of colony forming units (CFU) present after recovery to ambient conditions. The data were compared with previous results in which the same bacterial samples were exposed to static pressurization to the same pressures, for 15 minutes each. The results indicate that shock compression leads to survival of a significantly greater proportion of both WT and PA organisms. The significantly shorter duration of the pressure pulse during the shock experiments (2-3 μs) likely contributes to the increased survival of the microbial species. One reason for this can involve the crossover from deformable to rigid solid-like mechanical relaxational behavior that occurs for

  4. Generating minimal living systems from non-living materials and increasing their evolutionary abilities

    DEFF Research Database (Denmark)

    Rasmussen, Steen; Constantinescu, Adi; Svaneborg, Carsten

    2016-01-01

    We review lessons learned about evolutionary transitions from a bottom up construction of minimal life. We use a particular systemic protocell design process as a starting point for exploring two fundamental questions: (1) how may minimal living systems emerge from nonliving materials? - and (2......) how may minimal living systems support increasingly more evolutionary richness? Under (1) we present what has been accomplished so far and discuss the remaining open challenges and their possible solutions. Under (2) we present a design principle we have utilized successfully both for our...

  5. Study on development system of increasing gearbox for high-performance wind-power generator

    Science.gov (United States)

    Xu, Hongbin; Yan, Kejun; Zhao, Junyu

    2005-12-01

    Based on the analysis of the development potentiality of wind-power generator and domestic manufacture of its key parts in China, an independent development system of the Increasing Gearbox for High-performance Wind-power Generator (IGHPWG) was introduced. The main elements of the system were studied, including the procedure design, design analysis system, manufacturing technology and detecting system, and the relative important technologies were analyzed such as mixed optimal joint transmission structure of the first planetary drive with two grade parallel axle drive based on equal strength, tooth root round cutting technology before milling hard tooth surface, high-precise tooth grinding technology, heat treatment optimal technology and complex surface technique, and rig test and detection technique of IGHPWG. The development conception was advanced the data share and quality assurance system through all the elements of the development system. The increasing Gearboxes for 600KW and 1MW Wind-power Generator have been successfully developed through the application of the development system.

  6. DESTRUCTION OF INTERSTELLAR DUST IN EVOLVING SUPERNOVA REMNANT SHOCK WAVES

    International Nuclear Information System (INIS)

    Slavin, Jonathan D.; Dwek, Eli; Jones, Anthony P.

    2015-01-01

    Supernova generated shock waves are responsible for most of the destruction of dust grains in the interstellar medium (ISM). Calculations of the dust destruction timescale have so far been carried out using plane parallel steady shocks, however, that approximation breaks down when the destruction timescale becomes longer than that for the evolution of the supernova remnant (SNR) shock. In this paper we present new calculations of grain destruction in evolving, radiative SNRs. To facilitate comparison with the previous study by Jones et al., we adopt the same dust properties as in that paper. We find that the efficiencies of grain destruction are most divergent from those for a steady shock when the thermal history of a shocked gas parcel in the SNR differs significantly from that behind a steady shock. This occurs in shocks with velocities ≳200 km s −1 for which the remnant is just beginning to go radiative. Assuming SNRs evolve in a warm phase dominated ISM, we find dust destruction timescales are increased by a factor of ∼2 compared to those of Jones et al., who assumed a hot gas dominated ISM. Recent estimates of supernova rates and ISM mass lead to another factor of ∼3 increase in the destruction timescales, resulting in a silicate grain destruction timescale of ∼2–3 Gyr. These increases, while not able to resolve the problem of the discrepant timescales for silicate grain destruction and creation, are an important step toward understanding the origin and evolution of dust in the ISM

  7. Risk shocks and housing markets

    OpenAIRE

    Dorofeenko, Viktor; Lee, Gabriel S.; Salyer, Kevin D.

    2010-01-01

    Abstract: This paper analyzes the role of uncertainty in a multi-sector housing model with financial frictions. We include time varying uncertainty (i.e. risk shocks) in the technology shocks that affect housing production. The analysis demonstratesthat risk shocks to the housing production sector are a quantitatively important impulse mechanism for the business cycle. Also, we demonstrate that bankruptcy costs act as an endogenous markup factor in housing prices; as a consequence, the volati...

  8. Use of di(2-ethylhexyl)phthalate-containing infusion systems increases the risk for cholestasis.

    Science.gov (United States)

    von Rettberg, Heike; Hannman, Torsten; Subotic, Ulrike; Brade, Joachim; Schaible, Thomas; Waag, Karl Ludwig; Loff, Steffan

    2009-08-01

    Most polyvinylchloride infusion systems are plasticized with up to 60% of di(2-ethylhexyl)phthalate (DEHP). DEHP is easily extracted from the tubing by total parenteral nutrition (TPN) solutions and has been shown to have toxic effects on various organ systems including the liver in animals and humans. A role was postulated for DEHP in the development of hepatobiliary dysfunction in premature and newborn infants receiving parenteral nutrition, and the incidence of cholestasis was investigated after changing from polyvinylchloride infusion systems to polyvinylchloride-free infusion systems. Two 3-year periods from 1998 to 2004 were investigated retrospectively before and after changing from polyvinylchloride to polyvinylchloride-free infusion systems in our department. This resulted in 1 group of 30 patients treated with polyvinylchloride lines and a second group of 46 patients treated with polyvinylchloride-free lines. The 2 groups were examined for the incidence of cholestasis and other possible contributing factors. Statistics were performed by using SAS software (SAS Institute, Cary, NC). After changing infusion systems, the incidence of cholestasis dropped from 50% to 13%. Using DEHP-plasticized polyvinylchloride infusion systems for TPN increased the risk for cholestasis by a factor of 5.6. The use of polyvinylchloride lines correlated strongly with the development of TPN-associated cholestasis (P = .0004). Using DEHP-containing polyvinylchloride infusions systems contributes to the development of cholestasis. Therefore, the use of DEHP-free infusion systems for TPN is recommended, especially in premature and newborn infants.

  9. Vascular Stiffness and Increased Pulse Pressure in the Aging Cardiovascular System

    Directory of Open Access Journals (Sweden)

    Jochen Steppan

    2011-01-01

    Full Text Available Aging leads to a multitude of changes in the cardiovascular system, including systolic hypertension, increased central vascular stiffness, and increased pulse pressure. In this paper we will review the effects of age-associated increased vascular stiffness on systolic blood pressure, pulse pressure, augmentation index, and cardiac workload. Additionally we will describe pulse wave velocity as a method to measure vascular stiffness and review the impact of increased vascular stiffness as an index of vascular health and as a predictor of adverse cardiovascular outcomes. Furthermore, we will discuss the underlying mechanisms and how these may be modified in order to change the outcomes. A thorough understanding of these concepts is of paramount importance and has therapeutic implications for the increasingly elderly population.

  10. On terminating Poisson processes in some shock models

    Energy Technology Data Exchange (ETDEWEB)

    Finkelstein, Maxim, E-mail: FinkelMI@ufs.ac.z [Department of Mathematical Statistics, University of the Free State, Bloemfontein (South Africa); Max Planck Institute for Demographic Research, Rostock (Germany); Marais, Francois, E-mail: fmarais@csc.co [CSC, Cape Town (South Africa)

    2010-08-15

    A system subject to a point process of shocks is considered. Shocks occur in accordance with the homogeneous Poisson process. Different criteria of system failure (termination) are discussed and the corresponding probabilities of failure (accident)-free performance are derived. The described analytical approach is based on deriving integral equations for each setting and solving these equations through the Laplace transform. Some approximations are analyzed and further generalizations and applications are discussed.

  11. On terminating Poisson processes in some shock models

    International Nuclear Information System (INIS)

    Finkelstein, Maxim; Marais, Francois

    2010-01-01

    A system subject to a point process of shocks is considered. Shocks occur in accordance with the homogeneous Poisson process. Different criteria of system failure (termination) are discussed and the corresponding probabilities of failure (accident)-free performance are derived. The described analytical approach is based on deriving integral equations for each setting and solving these equations through the Laplace transform. Some approximations are analyzed and further generalizations and applications are discussed.

  12. Smallholder dairy systems in the Kenya highlands: cattle population dynamics under increasing intensification

    NARCIS (Netherlands)

    Bebe, B.O.; Udo, H.M.J.; Rowlands, G.J.; Thorpe, W.

    2003-01-01

    A cross-sectional stratified random sample survey of 1755 households in the Kenya highlands was conducted between June 1996 and April 1998 to quantify cattle population dynamics in smallholder herds. The free-, semi-zero- and zero-grazing systems practised represented increasing levels of

  13. Systems Thinking as a Competency for Community College Leaders in an Era of Increasing Complexity

    Science.gov (United States)

    Davis, Anne Powel

    2013-01-01

    The pluralistic and often competing goals of myriad constituents, the changing demographics of students, the uncertainty of funding, and the growing demands for accountability from stakeholders have increased the complexity of systems which community college leaders must manage. Emerging from the recent literature on community colleges is a call…

  14. Increased productivity in power plants by the computer-based information system PRAUT

    International Nuclear Information System (INIS)

    Hanbaba, P.

    1978-01-01

    Decrease of commissionning times, reduction of shut-down periods, avoiding of power reductions, fast adaption to load requirement variations act in the direction of increasing the productivity of a power plant. An essential contribution to this is provided by harmonized control, monitoring and communications concepts as realized, e.g. in the PRO-CONTROL system by Brown Boveri. (orig.) [de

  15. Increasing the technical and economic performance of wind diesel systems by including fresh water production

    DEFF Research Database (Denmark)

    Bindner, H.; Lundsager, P.

    1996-01-01

    In many remote regions of the world there is a lack of both electricity and potable water. In order to increase the standard of living and thus maintain the population both power and water have to be supplied at reasonable prices. A good option at many of these places are wind diesel systems...

  16. Infections Increase Risk of Arterial and Venous Thromboses in Danish Patients with Systemic Lupus Erythematosus

    DEFF Research Database (Denmark)

    Baronaite Hansen, Renata; Jacobsen, Søren

    2014-01-01

    OBJECTIVE: Infections and thromboses are known complications of systemic lupus erythematosus (SLE). We investigated if infectious episodes in patients with SLE were followed by an increased risk of thrombotic events. METHODS: A cohort of 571 patients with prevalent or incident SLE was followed...

  17. Cost-optimal electricity systems with increasing renewable energy penetration for islands across the globe

    NARCIS (Netherlands)

    Blok, K.; van Velzen, Leonore

    2018-01-01

    Cost-optimal electricity system configurations with increasing renewable energy penetration were determined in this article for six islands of different geographies, sizes and contexts, utilizing photovoltaic energy, wind energy, pumped hydro storage and battery storage. The results of the

  18. Does responsive pricing smooth demand shocks?

    OpenAIRE

    Pascal, Courty; Mario, Pagliero

    2011-01-01

    Using data from a unique pricing experiment, we investigate Vickrey’s conjecture that responsive pricing can be used to smooth both predictable and unpredictable demand shocks. Our evidence shows that increasing the responsiveness of price to demand conditions reduces the magnitude of deviations in capacity utilization rates from a pre-determined target level. A 10 percent increase in price variability leads to a decrease in the variability of capacity utilization rates between...

  19. Shock compression of diamond crystal

    OpenAIRE

    Kondo, Ken-ichi; Ahrens, Thomas J.

    1983-01-01

    Two shock wave experiments employing inclined mirrors have been carried out to determine the Hugoniot elastic limit (HEL), final shock state at 191 and 217 GPa, and the post-shock state of diamond crystal, which is shock-compressed along the intermediate direction between the and crystallographic axes. The HEL wave has a velocity of 19.9 ± 0.3 mm/µsec and an amplitude of 63 ± 28 GPa. An alternate interpretation of the inclined wedge mirror streak record suggests a ramp precursor wave and th...

  20. A Method to Increase Drivers' Trust in Collision Warning Systems Based on Reliability Information of Sensor

    Science.gov (United States)

    Tsutsumi, Shigeyoshi; Wada, Takahiro; Akita, Tokihiko; Doi, Shun'ichi

    Driver's workload tends to be increased during driving under complicated traffic environments like a lane change. In such cases, rear collision warning is effective for reduction of cognitive workload. On the other hand, it is pointed out that false alarm or missing alarm caused by sensor errors leads to decrease of driver' s trust in the warning system and it can result in low efficiency of the system. Suppose that reliability information of the sensor is provided in real-time. In this paper, we propose a new warning method to increase driver' s trust in the system even with low sensor reliability utilizing the sensor reliability information. The effectiveness of the warning methods is shown by driving simulator experiments.

  1. Hydropower: a vital asset in a power system with increased need for flexibility and firm capacity

    International Nuclear Information System (INIS)

    Weisrock, Ghislain

    2016-02-01

    In a power system with increased need for flexibility, wind and solar power are characterised by considerable volatility across different scales and their output cannot be predicted with certainty. In order to deal with the resulting variations and forecast errors, system operators as well as electricity markets will need to have access to increasing volumes of flexibility as the penetration of wind and solar power grows. Due to their flexibility and size, hydropower plants are perfectly suited for supplying these capabilities to current and future electricity markets and power systems. Storage as well as pump storage plants can be quickly started within a few minutes and adjust their output within seconds. Consequently, hydropower plants are able to follow even major variations in real time. (author)

  2. A Shocking Solar Nebula?

    OpenAIRE

    Liffman, Kurt

    2009-01-01

    It has been suggested that shock waves in the solar nebula formed the high temperature materials observed in meteorites and comets. It is shown that the temperatures at the inner rim of the solar nebula could have been high enough over a sufficient length of time to produce chondrules, CAIs, refractory dust grains and other high-temperature materials observed in comets and meteorites. The solar bipolar jet flow may have produced an enrichment of 16O in the solar nebula over time and the chond...

  3. Myths of "shock therapy".

    Science.gov (United States)

    Fink, M

    1977-09-01

    The author discusses the myths of the ECT process--that shock and the convulsion are essential, memory loss and brain damage are inescapable, and little is known of the process--and assesses the fallacies in these ideas. Present views of the ECT process suggest that its mode of action in depression may best be described as a prolonged form of diencephalic stimulation, particularly useful to affect the hypothalamic dysfunctions that characterize depressive illness. The author emphasizes the need for further study of this treatment modality and for self-regulation by the profession.

  4. Discrimination of Thermal versus Mechanical Effects of Shock on Rock Magnetic Properties of Spherically Shocked up to 10-160 GPa Basalt and Diabase

    Science.gov (United States)

    Bezaeva, N. S.; Swanson-Hysell, N.; Tikoo, S.; Badyukov, D. D.; Kars, M. A. C.; Egli, R.; Chareev, D. A.; Fairchild, L. M.

    2016-12-01

    Understanding how shock waves generated during hypervelocity impacts affect rock magnetic properties is key for interpreting the paleomagnetic records of lunar rocks, meteorites, and cratered planetary surfaces. Laboratory simulations of impacts show that ultra-high shocks may induce substantial post-shock heating of the target material. At high pressures (>10 GPa), shock heating occurs in tandem with mechanical effects, such as grain fracturing and creation of crystallographic defects and dislocations within magnetic grains. This makes it difficult to conclude whether shock-induced changes in the rock magnetic properties of target materials are primarily associated with mechanical or thermal effects. Here we present novel experimental methods to discriminate between mechanical and thermal effects of shock on magnetic properties and illustrate it with two examples of spherically shocked terrestrial basalt and diabase [1], which were shocked to pressures of 10 to >160 GPa, and investigate possible explanations for the observed shock-induced magnetic hardening (i.e., increase in remanent coercivity Bcr). The methods consist of i) conducting extra heating experiments at temperatures resembling those experienced during high-pressure shock events on untreated equivalents of shocked rocks (with further comparison of Bcr of shocked and heated samples) and ii) quantitative comparison of high-resolution first-order reversal curve (FORC) diagrams (field step: 0.5-0.7 mT) for shocked, heated and untreated specimens. Using this approach, we demonstrated that the shock-induced coercivity hardening in our samples is predominantly due to solid-state, mechanical effects of shock rather than alteration associated with shock heating. Indeed, heating-induced changes in Bcr in the post-shock temperature range were minor. Visual inspection of FORC contours (in addition to detailed analyses) reveals a stretching of the FORC distribution of shocked sample towards higher coercivities

  5. Energy harvesting from human motion: exploiting swing and shock excitations

    International Nuclear Information System (INIS)

    Ylli, K; Hoffmann, D; Willmann, A; Becker, P; Folkmer, B; Manoli, Y

    2015-01-01

    Modern compact and low power sensors and systems are leading towards increasingly integrated wearable systems. One key bottleneck of this technology is the power supply. The use of energy harvesting techniques offers a way of supplying sensor systems without the need for batteries and maintenance. In this work we present the development and characterization of two inductive energy harvesters which exploit different characteristics of the human gait. A multi-coil topology harvester is presented which uses the swing motion of the foot. The second device is a shock-type harvester which is excited into resonance upon heel strike. Both devices were modeled and designed with the key constraint of device height in mind, in order to facilitate the integration into the shoe sole. The devices were characterized under different motion speeds and with two test subjects on a treadmill. An average power output of up to 0.84 mW is achieved with the swing harvester. With a total device volume including the housing of 21 cm 3 a power density of 40 μW cm −3 results. The shock harvester generates an average power output of up to 4.13 mW. The power density amounts to 86 μW cm −3 for the total device volume of 48 cm 3 . Difficulties and potential improvements are discussed briefly. (paper)

  6. Humoral Dysregulation Associated with Increased Systemic Inflammation among Injection Heroin Users.

    Directory of Open Access Journals (Sweden)

    Michael S Piepenbrink

    Full Text Available Injection drug use is a growing major public health concern. Injection drug users (IDUs have a higher incidence of co-morbidities including HIV, Hepatitis, and other infections. An effective humoral response is critical for optimal homeostasis and protection from infection; however, the impact of injection heroin use on humoral immunity is poorly understood. We hypothesized that IDUs have altered B cell and antibody profiles.A comprehensive systems biology-based cross-sectional assessment of 130 peripheral blood B cell flow cytometry- and plasma- based features was performed on HIV-/Hepatitis C-, active heroin IDUs who participated in a syringe exchange program (n = 19 and healthy control subjects (n = 19. The IDU group had substantial polydrug use, with 89% reporting cocaine injection within the preceding month. IDUs exhibited a significant, 2-fold increase in total B cells compared to healthy subjects, which was associated with increased activated B cell subsets. Although plasma total IgG titers were similar between groups, IDUs had significantly higher IgG3 and IgG4, suggestive of chronic B cell activation. Total IgM was also increased in IDUs, as well as HIV Envelope-specific IgM, suggestive of increased HIV exposure. IDUs exhibited numerous features suggestive of systemic inflammation, including significantly increased plasma sCD40L, TNF-α, TGF-α, IL-8, and ceramide metabolites. Machine learning multivariate analysis distilled a set of 10 features that classified samples based on group with absolute accuracy.These results demonstrate broad alterations in the steady-state humoral profile of IDUs that are associated with increased systemic inflammation. Such dysregulation may impact the ability of IDUs to generate optimal responses to vaccination and infection, or lead to increased risk for inflammation-related co-morbidities, and should be considered when developing immune-based interventions for this growing population.

  7. Shock-wave propagation and reflection in semicrystalline polyethylene: A molecular-level investigation

    Science.gov (United States)

    Elder, Robert M.; O'Connor, Thomas C.; Chantawansri, Tanya L.; Sliozberg, Yelena R.; Sirk, Timothy W.; Yeh, In-Chul; Robbins, Mark O.; Andzelm, Jan W.

    2017-09-01

    Semicrystalline polyethylene (PE) is attractive for a variety of mechanically demanding applications, where shock compression can occur. Although often highly crystalline, PE invariably contains nanoscale amorphous domains that influence shock propagation. Our objective in this work is to study the effects of such domains. To this end, we adopt a novel approach wherein we parametrize a simple continuum-level theory based on the shock impedance from molecular dynamics (MD) simulations. Using this theory, we predict how crystalline/amorphous interfaces attenuate shocks via energy reflection due to the impedance mismatch between the phases. The theory predicts that these interfaces attenuate weak shocks more effectively than strong shocks. We compare the theory to explicit nonequilibrium MD simulations of compressive shocks in semicrystalline PE containing nanometer-scale amorphous regions of varying size, where we analyze the pressure response and reflection of energy. The theory and simulations show good agreement for strong shocks (≥1.0 km /s ), but for weak shocks (shock front. However, the simulations show that when amorphous domains are narrow—with widths comparable to the shock front—reflection is reduced compared to the predictions. We identify several nanoscale mechanisms that reduce the impedance mismatch, and thus reduce reflection, at thin amorphous domains. First, the two-wave elastic-plastic structure of shocks in crystalline PE allows the faster-moving elastic precursor wave to compress small amorphous domains before the plastic wave arrives. Second, confinement between stiff, ordered crystalline domains increases the stiffness and chain ordering in small amorphous regions. Moreover, in terms of stiffness the interfaces are similar in width to the shock front, which may contribute to the underprediction of the theory for weak shocks, where the shock front is widest. We conclude by discussing the significance of these results, namely, how they can

  8. A nova outburst powered by shocks

    Science.gov (United States)

    Li, Kwan-Lok; Metzger, Brian D.; Chomiuk, Laura; Vurm, Indrek; Strader, Jay; Finzell, Thomas; Beloborodov, Andrei M.; Nelson, Thomas; Shappee, Benjamin J.; Kochanek, Christopher S.; Prieto, José L.; Kafka, Stella; Holoien, Thomas W.-S.; Thompson, Todd A.; Luckas, Paul J.; Itoh, Hiroshi

    2017-10-01

    Classical novae are runaway thermonuclear burning events on the surfaces of accreting white dwarfs in close binary star systems, sometimes appearing as new naked-eye sources in the night sky1. The standard model of novae predicts that their optical luminosity derives from energy released near the hot white dwarf, which is reprocessed through the ejected material2-5. Recent studies using the Fermi Large Area Telescope have shown that many classical novae are accompanied by gigaelectronvolt γ-ray emission6,7. This emission likely originates from strong shocks, providing new insights into the properties of nova outflows and allowing them to be used as laboratories for the study of the unknown efficiency of particle acceleration in shocks. Here, we report γ-ray and optical observations of the Milky Way nova ASASSN-16ma, which is among the brightest novae ever detected in γ-rays. The γ-ray and optical light curves show a remarkable correlation, implying that the majority of the optical light comes from reprocessed emission from shocks rather than the white dwarf8. The ratio of γ-ray to optical flux in ASASSN-16ma directly constrains the acceleration efficiency of non-thermal particles to be around 0.005, favouring hadronic models for the γ-ray emission9. The need to accelerate particles up to energies exceeding 100 gigaelectronvolts provides compelling evidence for magnetic field amplification in the shocks.

  9. Gravitational shock waves and extreme magnetomaterial shock waves

    International Nuclear Information System (INIS)

    Lichnerowicz, Andre.

    1975-01-01

    Within an astrophysical context corresponding to high densities, a self-gravitating model is studied, which is the set of an extreme material medium of infinite conductivity and of a magnetic field. Corresponding shock waves generate necessarily, in general, gravitational shock waves [fr

  10. Shock Producers and Shock Absorbers in the Crisis

    OpenAIRE

    Sinn, Hans-Werner

    2009-01-01

    It is not surprising that the U.S. has been by far the world’s largest shock producer in this crisis. The big shock absorbers on the other hand were Japan, Russia and Germany, whose exports shrank more than their imports.

  11. Fast, multiphase volume adaptation to hyperosmotic shock by Escherichia coli.

    Directory of Open Access Journals (Sweden)

    Teuta Pilizota

    Full Text Available All living cells employ an array of different mechanisms to help them survive changes in extra cellular osmotic pressure. The difference in the concentration of chemicals in a bacterium's cytoplasm and the external environment generates an osmotic pressure that inflates the cell. It is thought that the bacterium Escherichia coli use a number of interconnected systems to adapt to changes in external pressure, allowing them to maintain turgor and live in surroundings that range more than two-hundred-fold in external osmolality. Here, we use fluorescence imaging to make the first measurements of cell volume changes over time during hyperosmotic shock and subsequent adaptation on a single cell level in vivo with a time resolution on the order of seconds. We directly observe two previously unseen phases of the cytoplasmic water efflux upon hyperosmotic shock. Furthermore, we monitor cell volume changes during the post-shock recovery and observe a two-phase response that depends on the shock magnitude. The initial phase of recovery is fast, on the order of 15-20 min and shows little cell-to-cell variation. For large sucrose shocks, a secondary phase that lasts several hours adds to the recovery. We find that cells are able to recover fully from shocks as high as 1 Osmol/kg using existing systems, but that for larger shocks, protein synthesis is required for full recovery.

  12. Increasing Fuel Efficiency of Direct Methanol Fuel Cell Systems with Feedforward Control of the Operating Concentration

    Directory of Open Access Journals (Sweden)

    Youngseung Na

    2015-09-01

    Full Text Available Most of the R&D on fuel cells for portable applications concentrates on increasing efficiencies and energy densities to compete with other energy storage devices, especially batteries. To improve the efficiency of direct methanol fuel cell (DMFC systems, several modifications to system layouts and operating strategies are considered in this paper, rather than modifications to the fuel cell itself. Two modified DMFC systems are presented, one with an additional inline mixer and a further modification of it with a separate tank to recover condensed water. The set point for methanol concentration control in the solution is determined by fuel efficiency and varies with the current and other process variables. Feedforward concentration control enables variable concentration for dynamic loads. Simulation results were validated experimentally with fuel cell systems.

  13. Electrostatic and electromagnetic turbulence associated with the Earth's bow shock

    International Nuclear Information System (INIS)

    Rodriguez, P.

    1974-01-01

    The electric and magnetic field spectral densities of plasma waves in the earth's bow shock have been measured in the frequency range 20 Hz to 200 kHz using two 16-channel spectrum analyzers on the IMP-6 spacecraft. Electrostatic noise with a spectrum similar to the turbulence in the shock, but with lower intensities, is observed throughout the magnetosheath region, downstream of the shock. The intensity of the electrostatic component of turbulence in the bow shock increases as the upstream electron to ion temperature ratio increases, and decreases as the upstream sound velocity increases; both of these variations for the electrostatic component are consistent with ion sound wave turbulence. (U.S.)

  14. A pictorial review of hypovolaemic shock in adults.

    LENUS (Irish Health Repository)

    Tarrant, A M

    2012-02-03

    Hypovolaemic shock is an infrequently encountered entity found on CT of victims of severe trauma. Early abdominal and pelvic CT can show diffuse abnormalities owing to hypovolaemia that may alert radiologists to the presence of hypovolaemic shock. In this pictorial review, we present the imaging findings of hypovolaemic shock, as seen on CT of the abdomen. A spectrum of vascular and visceral CT signs is described. Vascular signs include diminished inferior vena cava diameter, diminished aortic diameter and abnormal vascular enhancement. Hollow visceral abnormalities include diffuse increased mucosal enhancement of both the small and large bowel, diffuse thickening of the small bowel wall, and small bowel dilatation. Solid visceral abnormalities include both decreased and increased end organ enhancement. This report should increase radiologists\\' awareness of the CT manifestations of hypovolaemic shock.

  15. Thermal power plant operating regimes in future British power systems with increasing variable renewable penetration

    International Nuclear Information System (INIS)

    Edmunds, Ray; Davies, Lloyd; Deane, Paul; Pourkashanian, Mohamed

    2015-01-01

    Highlights: • This work investigates thermal power operating regimes in future power systems. • Gas plants have low utilisation in the scenarios considered. • Ramping intensity increases for gas plants and pumped storage. • Coal plants frequently operate at minimum stable levels and start-ups increase. • Grid emission intensity and total emission production remains substantial. - Abstract: This work investigates the operational requirements of thermal power plants in a number of potential future British power systems with increasing variable renewable penetration. The PLEXOS Integrated Energy Model has been used to develop the market models, with PLEXOS employing mixed integer programming to solve the unit commitment and economic dispatch problem, subject to a number of constraints. Initially, a model of the British power system was developed and validated. Subsequently, a 2020 test model was developed to analyse a number of future system structures with differing fuel and carbon prices and generation mixes. The study has found that in three of the four scenarios considered, the utilisation of gas power plants will be relatively low, but remains fundamental to the security of supply. Also, gas plants will be subject to more intense ramping. The findings have consequent implications for energy policy as expensive government interventions may be required to prevent early decommissioning of gas capacity, should the prevailing market conditions not guarantee revenue adequacy.

  16. Parallel implementation of geometrical shock dynamics for two dimensional converging shock waves

    Science.gov (United States)

    Qiu, Shi; Liu, Kuang; Eliasson, Veronica

    2016-10-01

    Geometrical shock dynamics (GSD) theory is an appealing method to predict the shock motion in the sense that it is more computationally efficient than solving the traditional Euler equations, especially for converging shock waves. However, to solve and optimize large scale configurations, the main bottleneck is the computational cost. Among the existing numerical GSD schemes, there is only one that has been implemented on parallel computers, with the purpose to analyze detonation waves. To extend the computational advantage of the GSD theory to more general applications such as converging shock waves, a numerical implementation using a spatial decomposition method has been coupled with a front tracking approach on parallel computers. In addition, an efficient tridiagonal system solver for massively parallel computers has been applied to resolve the most expensive function in this implementation, resulting in an efficiency of 0.93 while using 32 HPCC cores. Moreover, symmetric boundary conditions have been developed to further reduce the computational cost, achieving a speedup of 19.26 for a 12-sided polygonal converging shock.

  17. Increased functional connectivity between prefrontal cortex and reward system in pathological gambling.

    Directory of Open Access Journals (Sweden)

    Saskia Koehler

    Full Text Available Pathological gambling (PG shares clinical characteristics with substance-use disorders and is thus discussed as a behavioral addiction. Recent neuroimaging studies on PG report functional changes in prefrontal structures and the mesolimbic reward system. While an imbalance between these structures has been related to addictive behavior, whether their dysfunction in PG is reflected in the interaction between them remains unclear. We addressed this question using functional connectivity resting-state fMRI in male subjects with PG and controls. Seed-based functional connectivity was computed using two regions-of-interest, based on the results of a previous voxel-based morphometry study, located in the prefrontal cortex and the mesolimbic reward system (right middle frontal gyrus and right ventral striatum. PG patients demonstrated increased connectivity from the right middle frontal gyrus to the right striatum as compared to controls, which was also positively correlated with nonplanning aspect of impulsiveness, smoking and craving scores in the PG group. Moreover, PG patients demonstrated decreased connectivity from the right middle frontal gyrus to other prefrontal areas as compared to controls. The right ventral striatum demonstrated increased connectivity to the right superior and middle frontal gyrus and left cerebellum in PG patients as compared to controls. The increased connectivity to the cerebellum was positively correlated with smoking in the PG group. Our results provide further evidence for alterations in functional connectivity in PG with increased connectivity between prefrontal regions and the reward system, similar to connectivity changes reported in substance use disorder.

  18. Network Capacity Assessment and Increase in Systems with Intermittent Water Supply

    Directory of Open Access Journals (Sweden)

    Amilkar E. Ilaya-Ayza

    2016-03-01

    Full Text Available Water supply systems have been facing many challenges in recent decades due to the potential effects of climate change and rapid population growth. Water systems need to expand because of demographic growth. Therefore, evaluating and increasing system capacity is crucial. Specifically, we analyze network capacity as one of the main features of a system. When the network capacity starts to decrease, there is a risk that continuous supply will become intermittent. This paper discusses how network expansion carried out throughout the network life span typically reduces network capacity, thus transforming a system originally designed to work with continuous supply into a system with intermittent supply. A method is proposed to expand the network capacity in an environment of economic scarcity through a greedy algorithm that enables the definition of a schedule for pipe modification stages, and thus efficiently expands the network capacity. This method is, at the same time, an important step in the process of changing a water system from intermittent back to continuous supply—an achievement that remains one of the main challenges related to water and health in developing countries.

  19. Disintegration of power grid as part of the task of increasing functionality of electric system

    Directory of Open Access Journals (Sweden)

    Mukatov Bekzhan

    2017-01-01

    operation is inevitable with reduced reliability or, otherwise, with incomplete functionality where functionality is the set of functions provided by the power system and the quality of their performance. With the mass input of distributed small generation in grids of almost all voltage classes it is necessary to solve the problem of ensuring stability in previously passive distribution networks. The traditional approach based on the “struggle” to maintain synchronism between power plants in the distribution networks is associated with a number of difficulties, which causes to apply another approach to control modes in distribution networks. Complication of the power grid, automatic devices, increase in possible variations of modes, and tendency to maximize the use of production assets lead to an increase in the complexity of tasks solved by dispatch centers. In this regard, it is important to note that availability of cascade failures in power systems speaks of the urgency of the task of ensuring the survivability of energy supply systems both globally and locally. The paper shows how disintegration of the power grid can solve the task of ensuring the functionality of traditional power systems and help to create favorable conditions for distributed small generation integration into the integrated electric power system.

  20. LIGS measurements in the nozzle reservoir of a free-piston shock tunnel

    Science.gov (United States)

    Altenhöfer, P.; Sander, T.; Koroll, F.; Mundt, Ch.

    2018-02-01

    Free-piston shock tunnels are ground-based test facilities allowing the simulation of reentry flow conditions in a simple and cost-efficient way. For a better understanding of the processes occurring in a shock tunnel as well as for an optimal comparability of experimental data gained in shock tunnels to numerical simulations, it is highly desirable to have the best possible characterization of the generated test gas flows. This paper describes the final step of the development of a laser-induced grating spectroscopy (LIGS) system capable of measuring the temperature in the nozzle reservoir of a free-piston shock tunnel during tests: the successful adaptation of the measurement system to the shock tunnel. Preliminary measurements were taken with a high-speed camera and a LED lamp in order to investigate the optical transmissibility of the measurement volume during tests. The results helped to successfully measure LIGS signals in shock tube mode and shock tunnel mode in dry air seeded with NO. For the shock tube mode, six successful measurements for a shock Mach number of about 2.35 were taken in total, two of them behind the incoming shock (p ≈ 1 MPa, T ≈ 600 K) and four after the passing of the reflected shock (p ≈ 4 MPa, T ≈ 1000 K). For five of the six measurements, the derived temperatures were within a deviation range of 6% to a reference value calculated from measured shock speed. The uncertainty estimated was less than or equal to 3.5% for all six measurements. Two LIGS signals from measurements behind the reflected shock in shock tunnel mode were analyzed in detail. One of the signals allowed an unambiguous derivation of the temperature under the conditions of a shock with Mach 2.7 (p ≈ 5 MPa, T ≈ 1200 K, deviation 0.5% , uncertainty 4.9% ).