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Sample records for sheng lin yeh

  1. QING LIN

    QING LIN. Articles written in Journal of Genetics. Volume 96 Issue 4 September 2017 pp 535-544 RESEARCH ARTICLE. Effects of genetic variants of the bovine WNT8A gene on nine important growth traits in beef cattle · YONG-ZHEN HUANG YONG ZOU QING LIN HUA HE LI ZHENG ZI-JING ZHANG YONG-LONG DANG ...

  2. Security Analysis of Yeh-Tsai Security Mechanism

    Yum, Dae Hyun; Shin, Jong Hoon; Lee, Pil Joong

    Yeh and Tsai recently proposed an enhanced mobile commerce security mechanism. They modified the lightweight security mechanism due to Lam, Chung, Gu, and Sun to relieve the burden of mobile clients. However, this article shows that a malicious WAP gateway can successfully obtain the mobile client's PIN by sending a fake public key of a mobile commerce server and exploiting information leakage caused by addition operation. We also present a countermeasure against the proposed attack.

  3. Multinarasi Relief Yeh Pulu Basis Penciptaan Seni Lukis Kontemporer

    I Wayan Adnyana

    2018-05-01

    Full Text Available Kajian ini merupakan skema penelitian terapan, yang bertujuan untuk mengungkap konsep multinarasi relief Yeh Pulu, Bedulu, Gianyar, Bali, sebagai basis penciptaan seni lukis kontemporer. Secara metodologis penelitian ini dilakukan dalam dua tahapan: penelitian lapangan (kajian atas narasi relief berdasar perspektif ikonologi Panofsky (1971, dan berikutnya penelitian eksperimen terkait penciptaan seni lukis kontemporer berdasar perspektif ‘art practice as a research’ (Sullivan, 2005 yang menunjuk pada tiga tahapan: eksperimen medium, bahasa visual, dan penyusunan konteks yang relevan. Berdasar kajian ikonologi, terutama tahap analisis ikonografi, ditemukan bahwa narasi relief Yeh Pulu bersifat multinarasi, yakni pahatan relief yang memiliki beragam jenis tema cerita, seperti praktik pertanian, berburu, meditasi, pesta, asmara, dan lain-lain. Kemudian konsep multinarasi dalam penciptaan seni lukis kontemporer, menjadi: (a secara medium menggunakan multiteknik dan medium; (b bahasa visual, menghadirkan berbagai adegan secara berulang, terpadu dan bahkan terkesan saling berlawanan; (c konteks yang relevan, dengan memasukan ikon tokok-toko pahlawan dunia pop, seperti superman, superwomen, dan lain-lain. Secara ikonologis, bangunan visual yang mempertemukan adegan multinarasi relief Yeh Pulu dengan narasi kepahlawanan dunia pop, menjadi semakin menguatkan konsep multinarasi dalam membangun pesan kepahlawanan dunia sehari-hari dalam karya seni lukis kontemporer semakin berhasil. Penelitian ini melibatkan: Anak Agung Rai Remawa (pengumpul data, dan  Ni Luh Desi In Diana Sari (fotografi dan layout. This paper serves as an applied research scheme which aims to reveal the concept of multiple narratives of Yeh Pulu Relief, located in Bedulu, Bali, as the basis for the creation of contemporary painting. Methodologically speaking, this study was conducted in two stages: a field research (a field study on the relief narratives based on Panofsky

  4. Students Learn about Chinese Culture through the Folktale "Yeh-Shen": Emphasizing Figurative Language Interpretation

    Palmer, Barbara C.; Sun, Lingzhi; Leclere, Judith T.

    2012-01-01

    This article will analyze the figurative language that reflects Chinese traditional society and culture in "Yeh-Shen." The authors will consider both the figures of speech and the figures of thought (to include symbolism) that provide insight into an understanding of the Chinese culture through a reading of "Yeh-Shen." This analysis can be used by…

  5. YehZYXW of Escherichia coli Is a Low-Affinity, Non-Osmoregulatory Betaine-Specific ABC Transporter.

    Lang, Shenhui; Cressatti, Marisa; Mendoza, Kris E; Coumoundouros, Chelsea N; Plater, Samantha M; Culham, Doreen E; Kimber, Matthew S; Wood, Janet M

    2015-09-22

    Transporter-mediated osmolyte accumulation stimulates the growth of Escherichia coli in high-osmolality environments. YehZYXW was predicted to be an osmoregulatory transporter because (1) osmotic and stationary phase induction of yehZYXW is mediated by RpoS, (2) the Yeh proteins are homologous to the components of known osmoregulatory ABC transporters (e.g., ProU of E. coli), and (3) YehZ models based on the structures of periplasmic betaine-binding proteins suggested that YehZ retains key betaine-binding residues. The betaines choline-O-sulfate, glycine betaine, and dimethylsulfoniopropionate bound YehZ and ProX with millimolar and micromolar affinities, respectively, as determined by equilibrium dialysis and isothermal titration calorimetry. The crystal structure of the YehZ apoprotein, determined at 1.5 Å resolution (PDB ID: 4WEP ), confirmed its similarity to other betaine-binding proteins. Small and nonpolar residues in the hinge region of YehZ (e.g., Gly223) pack more closely than the corresponding residues in ProX, stabilizing the apoprotein. Betaines bound YehZ-Gly223Ser an order of magnitude more tightly than YehZ, suggesting that weak substrate binding in YehZ is at least partially due to apo state stabilization. Neither ProX nor YehZ bound proline. Assays based on osmoprotection or proline auxotrophy failed to detect YehZYXW-mediated uptake of proline, betaines, or other osmolytes. However, transport assays revealed low-affinity glycine betaine uptake, mediated by YehZYXW, that was inhibited at high salinity. Thus, YehZYXW is a betaine transporter that shares substrate specificity, but not an osmoregulatory function, with homologues like E. coli ProU. Other work suggests that yehZYXW may be an antivirulence locus whose expression promotes persistent, asymptomatic bacterial infection.

  6. SOSIALISASI KONSEP PARIWISATA BERKELANJUTAN DALAM PENGELOLAAN OBJEK WISATA PANTAI YEH GANGGA KABUPATEN TABANAN

    AGUS MURIAWAN PUTRA

    2012-10-01

    Full Text Available ABSTRACT The Bali Sustainable Development Project suggested that the sustainable development concept for Bali should reflect a balance between economy, environment and culture. This should, therefore incorporate the need for continuity of natural resources and production, the need for continuity of culture and the balances within culture, and development as an "optimum process" that can enhance quality of life. The Bali Sustainable Development Project has developed seven special criteria : (1 ecological integrity (2 efficiency (3 equity: (4cultural integrity (5 community (6 to integrate key factors, such as economy, environment, and agriculture and tourism; and (7 to enhance the capabilities of its institutions at all levels to address all needs and improve quality of life. Yeh Gangga Beach, the tourism destination in Tabanan was given a presentation from the Tourism Program of Udayana University about “Tourism Sustainable in Yeh Gangga Beach”. Responses from the people were very enthusiastics and positif because according factual issues in that destination, the people want to participate directly to increase the profit from that tourism activities.

  7. The impact of nonpolar lipids on the regulation of the steryl ester hydrolases Tgl1p and Yeh1p in the yeast Saccharomyces cerevisiae.

    Klein, Isabella; Korber, Martina; Athenstaedt, Karin; Daum, Günther

    2017-12-01

    In the yeast Saccharomyces cerevisiae degradation of steryl esters is catalyzed by the steryl ester hydrolases Tgl1p, Yeh1p and Yeh2p. The two steryl ester hydrolases Tgl1p and Yeh1p localize to lipid droplets, a cell compartment storing steryl esters and triacylglycerols. In the present study we investigated regulatory aspects of these two hydrolytic enzymes, namely the gene expression level, protein amount, stability and enzyme activity of Tgl1p and Yeh1p in strains lacking both or only one of the two major nonpolar lipids, steryl esters and triacylglycerols. In a strain lacking both nonpolar lipids and consequently lipid droplets, Tgl1p as well as Yeh1p were present at low amount, became highly unstable compared to wild-type cells, and lost their enzymatic activity. Under these conditions both steryl ester hydrolases were retained in the endoplasmic reticulum. The lack of steryl esters alone was not sufficient to cause an altered intracellular localization of Tgl1p and Yeh1p. Surprisingly, the stability of Tgl1p and Yeh1p was markedly reduced in a strain lacking triacylglycerols, but their capacity to mobilize steryl esters remained unaffected. We also tested a possible cross-regulation of Tgl1p and Yeh1p by analyzing the behavior of each hydrolase in the absence of its counterpart steryl ester hydrolases. In summary, this study demonstrates a strong regulation of the two lipid droplet associated steryl ester hydrolases Tgl1p and Yeh1p due to the presence/absence of their host organelle. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. LINS Curve in Romanian Economy

    Emilian Dobrescu

    2016-02-01

    Full Text Available The paper presents theoretical considerations and empirical evidence to test the validity of the Laffer in Narrower Sense (LINS curve as a parabola with a maximum. Attention is focused on the so-called legal-effective tax gap (letg. The econometric application is based on statistical data (1990-2013 for Romania as an emerging European economy. Three cointegrating regressions (fully modified least squares, canonical cointegrating regression and dynamic least squares and three algorithms, which are based on instrumental variables (two-stage least squares, generalized method of moments, and limited information maximum likelihood, are involved.

  9. [Sheng's acupuncture manipulation at bone-nearby acupoints and the academic thoughts].

    Sheng, Ji-li; Jin, Xiao-qing

    2014-11-01

    Sheng's acupuncture manipulation at bone-nearby acupoints is a set of needling manipulation of the chief physician of TCM, SHENG Xie-sun, summarized through his over 50 years clinical experiences and on the basis of Internal Classic. Regarding this manipulation, on the premise of acupoint selection based on syndrome differentiation, the acupoints close to bone are possibly selected and punctured, with the needle tip toward bone edge, and followed by the technique to achieve reducing purpose. Clinically, the significant immediate analgesia can be achieved in pain disorders such as headache and toothache. Professor Sheng thought, corresponding to the location of needle insertion and needling depth, the tissue layers of needle tip passing through should be considered specially. The site of needle insertion should be changeable so as to ensure the needle tip reaching the bone. This manipulation for analgesia provides a certain guide for acupuncture study, especially for the mechanism study on acupuncture analgesia.

  10. 75 FR 32741 - Action Affecting Export Privileges; Shu Quan-Sheng

    2010-06-09

    ... illegally exporting space launch technical data and defense services to the People's Republic of China and offering bribes to Chinese government officials. Quan-Sheng was sentenced to 51 months in prison, two years... Regulations; B. Take any action that facilitates the acquisition or attempted acquisition by the Denied Person...

  11. lin-4 and the NRDE pathway are required to activate a transgenic lin-4 reporter but not the endogenous lin-4 locus in C. elegans.

    Alan L Jiao

    Full Text Available As the founding member of the microRNA (miRNA gene family, insights into lin-4 regulation and function have laid a conceptual foundation for countless miRNA-related studies that followed. We previously showed that a transcriptional lin-4 reporter in C. elegans was positively regulated by a lin-4-complementary element (LCE, and by lin-4 itself. In this study, we sought to (1 identify additional factors required for lin-4 reporter expression, and (2 validate the endogenous relevance of a potential positive autoregulatory mechanism of lin-4 expression. We report that all four core nuclear RNAi factors (nrde-1, nrde-2, nrde-3 and nrde-4, positively regulate lin-4 reporter expression. In contrast, endogenous lin-4 levels were largely unaffected in nrde-2;nrde-3 mutants. Further, an endogenous LCE deletion generated by CRISPR-Cas9 revealed that the LCE was also not necessary for the activity of the endogenous lin-4 promoter. Finally, mutations in mature lin-4 did not reduce primary lin-4 transcript levels. Taken together, these data indicate that under growth conditions that reveal effects at the transgenic locus, a direct, positive autoregulatory mechanism of lin-4 expression does not occur in the context of the endogenous lin-4 locus.

  12. lin-4 and the NRDE pathway are required to activate a transgenic lin-4 reporter but not the endogenous lin-4 locus in C. elegans.

    Jiao, Alan L; Foster, Daniel J; Dixon, Julia; Slack, Frank J

    2018-01-01

    As the founding member of the microRNA (miRNA) gene family, insights into lin-4 regulation and function have laid a conceptual foundation for countless miRNA-related studies that followed. We previously showed that a transcriptional lin-4 reporter in C. elegans was positively regulated by a lin-4-complementary element (LCE), and by lin-4 itself. In this study, we sought to (1) identify additional factors required for lin-4 reporter expression, and (2) validate the endogenous relevance of a potential positive autoregulatory mechanism of lin-4 expression. We report that all four core nuclear RNAi factors (nrde-1, nrde-2, nrde-3 and nrde-4), positively regulate lin-4 reporter expression. In contrast, endogenous lin-4 levels were largely unaffected in nrde-2;nrde-3 mutants. Further, an endogenous LCE deletion generated by CRISPR-Cas9 revealed that the LCE was also not necessary for the activity of the endogenous lin-4 promoter. Finally, mutations in mature lin-4 did not reduce primary lin-4 transcript levels. Taken together, these data indicate that under growth conditions that reveal effects at the transgenic locus, a direct, positive autoregulatory mechanism of lin-4 expression does not occur in the context of the endogenous lin-4 locus.

  13. In vitro expansion of Lin+ and Lin- mononuclear cells from human peripheral blood

    Norhaiza, H. Siti; Rohaya, M. A. W.; Zarina, Z. A. Intan; Hisham, Z. A. Shahrul

    2013-11-01

    Haematopoietic stem cells (HSCs) are used in the therapy of blood disorders due to the ability of these cells to reconstitute haematopoietic lineage cells when transplanted into myeloablative recipients. However, substantial number of cells is required in order for the reconstitution to take place. Since HSCs present in low frequency, larger number of donor is required to accommodate the demand of transplantable HSCs. Therefore, in vitro expansion of HSCs will have profound impact on clinical purposes. The aim of this study was to expand lineage negative (Lin-) stem cells from human peripheral blood. Total peripheral blood mononuclear cells (PBMNCs) were fractionated from human blood by density gradient centrifugation. Subsequently, PBMNCs were subjected to magnetic assisted cell sorter (MACS) which depletes lineage positive (Lin+) mononuclear cells expressing lineage positive markers such as CD2, CD3, CD11b, CD14, CD15, CD16, CD19, CD56, CD123, and CD235a to obtained Lin- cell population. The ability of Lin+ and Lin- to survive in vitro was explored by culturing both cell populations in complete medium consisting of Alpha-Minimal Essential Medium (AMEM) +10% (v/v) Newborn Calf Serum (NBCS)+ 2% (v/v) pen/strep. In another experiment, Lin+ and Lin- were cultured with complete medium supplemented with 10ng/mL of the following growth factors: stem cell factor (SCF), interleukin (IL)-3, granulocyte-macrophage colony stimulating factor (GM-CSF), 2IU/mL of Erythropoietin (Epo) and 20ng/mL of IL-6. Three samples were monitored in static culture for 22 days. The expansion potential was assessed by the number of total viable cells, counted by trypan blue exclusion assay. It was found that Lin+ mononuclear cells were not able to survive either in normal proliferation medium or proliferation medium supplemented with cytokines. Similarly, Lin- stem cells were not able to survive in proliferation medium however, addition of cytokines into the proliferation medium support Lin

  14. Lin28a regulates germ cell pool size and fertility

    Shinoda, Gen; de Soysa, T. Yvanka; Seligson, Marc T.; Yabuuchi, Akiko; Fujiwara, Yuko; Huang, Pei Yi; Hagan, John P.; Gregory, Richard I.; Moss, Eric G.; Daley, George Q.

    2013-01-01

    Overexpression of LIN28A is associated with human germ cell tumors and promotes primordial germ cell (PGC) development from embryonic stem cells in vitro and in chimeric mice. Knockdown of Lin28a inhibits PGC development in vitro, but how constitutional Lin28a deficiency affects the mammalian reproductive system in vivo remains unknown. Here, we generated Lin28a knockout (KO) mice and found that Lin28a deficiency compromises the size of the germ cell pool in both males and females by affecting PGC proliferation during embryogenesis. Interestingly however, in Lin28a KO males the germ cell pool partially recovers during postnatal expansion, while fertility remains impaired in both males and females mated to wild type mice. Embryonic overexpression of let-7, a microRNA negatively regulated by Lin28a, reduces the germ cell pool, corroborating the role of the Lin28a/let-7 axis in regulating the germ lineage. PMID:23378032

  15. Effect of ShengRu mistura on the serum and milk contents of PRL in postpartum women

    Yin Yong; Tang Shanling; Yuan Chengye; Xu Zheng'an; Ni Chunmei

    2005-01-01

    Objective: To observe the effect of ShengRu mistura on the amount of the milk secreted and serum/milk contents of prolactin (PRL) in post-partum women. Methods: ShengRu mistura, a Chinese traditional formula, was administered to 100 post-partum women at the dose of 100ml q 12h on d2 through d4 after normal delivery. Serum PRL (measured 2h after delivery and on d4) and milk PRL (measured on d2 and d4) contents were measured with RIA in these women as well as in 100 controls. The amount of milk secreted on d4 was noted. Results: The amounts of milk secreted on d4 were significantly larger in women receiving ShengRu mistura than those in controls (P<0.001). The serum and milk PRL levels were also significantly higher in women treated with ShengRu mistura than those in controls (P<0.001). Conclusion: ShengRu mistura was effective in promoting milk secretion with higher prolactin levels in serum and milk. (authors)

  16. [Textual research on Costus root (Aucklandia lappa Decne) in the Sheng nong ben cao jing (Shennong's Classic of Materia Medica)].

    Li, Guangyan; Wang, Dequn; Fang, Shiying; Xu, Maohong

    2014-05-01

    Aucklandia lappa Decne was first recorded in the Sheng nong ben cao jing (Shennong's Classic of Materia Medica). Through the textual research of herbal literature, it was found that the costus root in the Sheng nong ben cao jing perhaps was not the plant of Aucklandia lappa Decne of Compositae, but the eaglewood or Lignum Aquilasria Resinatum based on the comprehensive judgment of shape, taste, nature, and function etc. In the Sheng nong ben cao jing, it only includes costus root without the title of eaglewood, and Tao Hongjing recorded both herbs together in his Ming yi bie lu (Supplementary Records of Celebrated Physicians), which became a foreshadow of misunderstanding of the later generations. Beginning from the Tang ben cao (Materia Medica of the Tang Dynasty), the costus root was considered as the plant of Auckiandia lappa Decne from the Compostae with its profound influence until now.

  17. Analysis list: lin-13 [Chip-atlas[Archive

    Full Text Available lin-13 Embryo,Larvae + ce10 http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/...lin-13.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/lin-13.5.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/ce10/target/lin-13.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/lin-13.Embryo....tsv,http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/lin-13.Larvae.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/ce10/colo/Embryo.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/Larvae.gml ...

  18. Candice Lin: paisaje, territorio y fronteras (Candice Lin: Landscape, Territory and Boundaries

    Gabriel Baltodano Román

    2017-11-01

    Full Text Available Se analizan los contenidos ideológicos de la acuarela «Nacimiento de una nación» (2008, de Candice Lin. A partir de nociones como territorio, tropo caníbal, tipo botánico tropical y pensamiento fronterizo, se plantea una interpretación de esa paisajística pictórica, en que la artista-activista reflexiona sobre el régimen de representación visual. Mediante diversos procedimientos formales, Lin pone en entredicho preceptos centrales de la mentalidad colonialista, que contrapone a las concepciones indigenistas. Abstract An analysis is provided of the ideological contents of the watercolor “Birth of a Nation” (2008, by Candice Lin. This interpretation of this pictorial landscape is based on notions such as territory, cannibal tropes, tropical botanical types and border thinking. The artist activist reflects here on the regime of visual representation. Using different formal procedures, Lin questions central precepts of the colonialist mentality, in contrast with indigenous conceptions.

  19. The Lin28/let-7 Axis Regulates Glucose Metabolism

    Zhu, Hao; Shyh-Chang, Ng; Segre, Ayellet V.; Shinoda, Gen; Shah, Samar P.; Einhorn, William S.; Takeuchi, Ayumu; Engreitz, Jesse M.; Hagan, John P.; Kharas, Michael G.; Urbach, Achia; Thornton, James E.; Triboulet, Robinson; Gregory, Richard I.; Altshuler, David; Daley, George Q.

    2011-01-01

    The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/b promote malignancy by inhibiting let-7 biogenesis. We have uncovered unexpected roles for the Lin28/let-7 pathway in regulating-metabolism. When overexpressed in mice, both

  20. Analysis list: lin-35 [Chip-atlas[Archive

    Full Text Available lin-35 Adult,Larvae + ce10 http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/l...in-35.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/lin-35.5.tsv http://dbarchive.bioscienced...bc.jp/kyushu-u/ce10/target/lin-35.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/lin-35.Adult.t...sv,http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/lin-35.Larvae.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/ce10/colo/Adult.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/Larvae.gml ...

  1. The Lin28/let-7 axis regulates glucose metabolism

    Zhu, Hao; Shyh-Chang, Ng; Segrè, Ayellet V.; Shinoda, Gen; Shah, Samar P.; Einhorn, William S.; Takeuchi, Ayumu; Engreitz, Jesse M.; Hagan, John P.; Kharas, Michael G; Urbach, Achia; Thornton, James E.; Triboulet, Robinson; Gregory, Richard I.; Altshuler, David; Daley, George Q.

    2012-01-01

    SUMMARY The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/b promote malignancy by blocking let-7 biogenesis. In studies of the Lin28/let-7 pathway, we discovered unexpected roles in regulating metabolism. When overexpressed in mice, both Lin28a and LIN28B promoted an insulin-sensitized state that resisted high fat diet-induced diabetes, whereas muscle-specific loss of Lin28a and overexpression of let-7 resulted in insulin resistance and impaired glucose tolerance. These phenomena occurred in part through let-7-mediated repression of multiple components of the insulin-PI3K-mTOR pathway, including IGF1R, INSR, and IRS2. The mTOR inhibitor rapamycin abrogated the enhanced glucose uptake and insulin-sensitivity conferred by Lin28a in vitro and in vivo. In addition, we found that let-7 targets were enriched for genes that contain SNPs associated with type 2 diabetes and fasting glucose in human genome-wide association studies. These data establish the Lin28/let-7 pathway as a central regulator of mammalian glucose metabolism. PMID:21962509

  2. Identification and differentiation of major components in three different “Sheng-ma” crude drug species by UPLC/Q-TOF-MS

    Mengxue Fan

    2017-03-01

    Full Text Available Cimicifugae Rhizoma (Sheng ma is a Ranunculaceae herb belonging to a composite family and well known in China. has been widely used in traditional Chinese medicine. The Pharmacopoeia of the People׳s Republic of China contains three varieties (Cimicifuga dahurica (Turcz., Cimicifuga foetida L. and Cimicifuga heracleifolia Kom. which have been used clinically as “Sheng-ma”. However, the chemical constituents of three components of “Sheng-ma” have never been documented. In this study, a rapid method for the analysis of the main components of “Sheng-ma” was developed using ultra-high performance liquid chromatography with quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF-MS. The present study reveals the major common and distinct chemical constituents of C. dahurica, C. foetida and C. heracleifolia and also reports principal component and statistical analyses of these results. The components were identified by comparing the retention time, accurate mass, mass spectrometric fragmentation characteristic ions and matching empirical molecular formula with that of the published compounds. A total of 32 common components and 8 markers for different “Sheng-ma” components were identified. These findings provide an important basis for the further study and clinical utilities of the three “Sheng-ma” varieties.

  3. Using Lin's method to solve Bykov's problems

    Knobloch, Jürgen; Lamb, Jeroen S. W.; Webster, Kevin N.

    2014-10-01

    We consider nonwandering dynamics near heteroclinic cycles between two hyperbolic equilibria. The constituting heteroclinic connections are assumed to be such that one of them is transverse and isolated. Such heteroclinic cycles are associated with the termination of a branch of homoclinic solutions, and called T-points in this context. We study codimension-two T-points and their unfoldings in Rn. In our consideration we distinguish between cases with real and complex leading eigenvalues of the equilibria. In doing so we establish Lin's method as a unified approach to (re)gain and extend results of Bykov's seminal studies and related works. To a large extent our approach reduces the study to the discussion of intersections of lines and spirals in the plane. Case (RR): Under open conditions on the eigenvalues, there exist open sets in parameter space for which there exist periodic orbits close to the heteroclinic cycle. In addition, there exist two one-parameter families of homoclinic orbits to each of the saddle points p1 and p2.See Theorem 2.1 and Proposition 2.2 for precise statements and Fig. 2 for bifurcation diagrams. Cases (RC) and (CC): At the bifurcation point μ=0 and for each N≥2, there exists an invariant set S0N close to the heteroclinic cycle on which the first return map is topologically conjugated to a full shift on N symbols. For any fixed N≥2, the invariant set SμN persists for |μ| sufficiently small.In addition, there exist infinitely many transversal and non-transversal heteroclinic orbits connecting the saddle points p1 and p2 in a neighbourhood of μ=0, as well as infinitely many one-parameter families of homoclinic orbits to each of the saddle points.For full statements of the results see Theorem 2.3 and Propositions 2.4, 2.5 and Fig. 3 for bifurcation diagrams. The dynamics near T-points has been studied previously by Bykov [6-10], Glendinning and Sparrow [20], Kokubu [27,28] and Labouriau and Rodrigues [30,31,38]. See also the surveys

  4. Inhibitory effect of bofutsushosan (fang feng tong sheng san) on glucose transporter 5 function in vitro.

    Gao, Shengli; Satsu, Hideo; Makino, Toshiaki

    2018-03-01

    Bofutsushosan (BTS; fang feng tong sheng san in Chinese) is a formula in traditional Japanese Kampo medicine and Chinese medicine comprising eighteen crude drugs, and is used to treat obesity and metabolic syndrome. Fructose is contained in refreshing beverages as high-fructose corn syrup, and is associated with obesity. Fructose is absorbed via glucose transporter 5 (GLUT5) in the intestine. Therefore, the inhibition of GLUT5 is considered to be a target of obesity drugs. We evaluated the inhibitory effects of BTS extract and its constituents on fructose uptake using Chinese hamster ovary K1 cells, i.e., cells stably expressing GLUT5. Boiled water extract of BTS significantly suppressed GLUT5 function in a concentration-dependent manner without cytotoxicities. Among 18 components of BTS, the boiled water extracts of the rhizome of Zingiber officinale, the root and rhizome of Saposhnikovia divaricata, and the root of Platycodon grandiflorum exhibited significant inhibitory effects on fructose uptake with IC 50 values of 314, 119 and 475 µg/ml, respectively. Among the constituents of the rhizome of Z. officinale extract, 6-gingerol significantly inhibited GLUT5 with an IC 50 value of 39 µM, while 6-shogaol exhibited a significant but weak inhibition on GLUT5 at 100 µM. One of the mechanisms of action of BTS may be the inhibition of fructose absorption in the intestine, and one of the active components of BTS is the rhizome of Z. officinale and 6-gingerol.

  5. In vitro expansion of Lin{sup +} and Lin{sup −} mononuclear cells from human peripheral blood

    Norhaiza, H. Siti; Zarina, Z. A. Intan; Hisham, Z. A. Shahrul [School of Bioscience and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600, Selangor (Malaysia); Rohaya, M. A. W. [Department of Orthodontics, Faculty of Dentistry, Universiti Kebangsaan Malaysia, 50300, Kuala Lumpur (Malaysia)

    2013-11-27

    Haematopoietic stem cells (HSCs) are used in the therapy of blood disorders due to the ability of these cells to reconstitute haematopoietic lineage cells when transplanted into myeloablative recipients. However, substantial number of cells is required in order for the reconstitution to take place. Since HSCs present in low frequency, larger number of donor is required to accommodate the demand of transplantable HSCs. Therefore, in vitro expansion of HSCs will have profound impact on clinical purposes. The aim of this study was to expand lineage negative (Lin{sup −}) stem cells from human peripheral blood. Total peripheral blood mononuclear cells (PBMNCs) were fractionated from human blood by density gradient centrifugation. Subsequently, PBMNCs were subjected to magnetic assisted cell sorter (MACS) which depletes lineage positive (Lin{sup +}) mononuclear cells expressing lineage positive markers such as CD2, CD3, CD11b, CD14, CD15, CD16, CD19, CD56, CD123, and CD235a to obtained Lin{sup −} cell population. The ability of Lin{sup +} and Lin{sup −} to survive in vitro was explored by culturing both cell populations in complete medium consisting of Alpha-Minimal Essential Medium (AMEM) +10% (v/v) Newborn Calf Serum (NBCS)+ 2% (v/v) pen/strep. In another experiment, Lin{sup +} and Lin{sup −} were cultured with complete medium supplemented with 10ng/mL of the following growth factors: stem cell factor (SCF), interleukin (IL)-3, granulocyte-macrophage colony stimulating factor (GM-CSF), 2IU/mL of Erythropoietin (Epo) and 20ng/mL of IL-6. Three samples were monitored in static culture for 22 days. The expansion potential was assessed by the number of total viable cells, counted by trypan blue exclusion assay. It was found that Lin{sup +} mononuclear cells were not able to survive either in normal proliferation medium or proliferation medium supplemented with cytokines. Similarly, Lin{sup −} stem cells were not able to survive in proliferation medium however

  6. Selective blockade of microRNA processing by Lin-28

    Viswanathan, Srinivas R.; Daley, George Q.; Gregory, Richard I.

    2012-01-01

    MicroRNAs (miRNAs) play critical roles in development, and dysregulation of miRNA expression has been observed in human malignancies. Recent evidence suggests that the processing of several primary miRNA transcripts (pri-miRNAs) is blocked post-transcriptionally in embryonic stem (ES) cells, embryonal carcinoma (EC) cells, and primary tumors. Here we show that Lin-28, a developmentally regulated RNA-binding protein, selectively blocks the processing of pri-let-7 miRNAs in embryonic cells. Using in vitro and in vivo studies, we demonstrate that Lin-28 is necessary and sufficient for blocking Microprocessor-mediated cleavage of pri-let-7 miRNAs. Our results identify Lin-28 as a negative regulator of miRNA biogenesis and suggest that Lin-28 may play a central role in blocking miRNA-mediated differentiation in stem cells and certain cancers. PMID:18292307

  7. Lin28 sustains early renal progenitors and induces Wilms tumor

    Urbach, Achia; Yermalovich, Alena; Zhang, Jin; Spina, Catherine S.; Zhu, Hao; Perez-Atayde, Antonio R.; Shukrun, Rachel; Charlton, Jocelyn; Sebire, Neil; Mifsud, William; Dekel, Benjamin; Pritchard-Jones, Kathy; Daley, George Q.

    2014-01-01

    Wilms Tumor, the most common pediatric kidney cancer, evolves from the failure of terminal differentiation of the embryonic kidney. Here we show that overexpression of the heterochronic regulator Lin28 during kidney development in mice markedly expands nephrogenic progenitors by blocking their final wave of differentiation, ultimately resulting in a pathology highly reminiscent of Wilms tumor. Using lineage-specific promoters to target Lin28 to specific cell types, we observed Wilms tumor only when Lin28 is aberrantly expressed in multiple derivatives of the intermediate mesoderm, implicating the cell of origin as a multipotential renal progenitor. We show that withdrawal of Lin28 expression reverts tumorigenesis and markedly expands the numbers of glomerulus-like structures and that tumor formation is suppressed by enforced expression of Let-7 microRNA. Finally, we demonstrate overexpression of the LIN28B paralog in a significant percentage of human Wilms tumor. Our data thus implicate the Lin28/Let-7 pathway in kidney development and tumorigenesis. PMID:24732380

  8. Distribution characteristics of terrestrial heat flow density in Jiyang depression of Shengli Oilfield, East China

    GONG; Yuling; WANG; Liangshu; LIU; Shaowen; LI; Cheng; HAN

    2004-01-01

    Based on the geo-temperature data of 13 systematically continuous temperature log curves and 700 testing oil boreholes in Jiyang depression, Shengli Oilfield, and the measured thermal conductivities of 47 rock samples, the terrestrial heat flow densities of 114 boreholes of Jiyang depression and its surrounding areas are determined, including 13 of those data derived from systemically continuous temperature logging. The results show that Jiyang depression has a relatively high background heat flow with an average value (65.8 ± 5.4) mW/m2. The lateral variation of heat flow in basin has negative correlation with basement depth. Moreover, heat flow of uplift areas with shallower basement is high, so are those of regions with volcanic rocks, and those of depression areas with deep basement are relatively low. The heat flow densities of different structural units of Jiyang depression can be summarized as follows: The average heat flow value of Zhanhua sag is (67.4 ± 5.3) mW/m2, higher than that of the whole basin, that of Dongying sag is (66.0 ± 6.1) mW/m2, and that of Chezhen sag is (65.1 ± 3.7) mW/m2. It is apparent that these latter two values are approximate to the average value of the whole Jiyang depression,while the average value of Huimin sag is (63.6±5.0) mW/m2, lower than that of the whole basin. In fact, the basement depth and the distribution framework of uplift and depression areas are all controlled by the process of lithosphere extension. In addition, the distribution of volcanic rocks in basin is also relatively close to this extension geodynamic process. In summary, the distribution characteristics of terrestrial heat flow of Jiyang depression is determined by the Cenozoic tectono-thermal events of this region.

  9. Lin's theory of flux and nuclear reactions

    Ping-Wha Lin

    2002-01-01

    Mathematical development of Lin's theory of flux is presented. Based on the Theory, when a chemical reaction system is subjected to a high time rate of temperature change, it changes from equilibrium to non-equilibrium conditions. It is proved mathematically that, when a gas system is subjected to a high time rate of temperature increase, the activities of particles (molecules, atoms or nuclei, and electrons) are increased: the particles are accelerated; frequencies and amplitudes of electron and atomic vibrations in a molecule increased; average kinetic energy of the particles increased; atomic bonds are ruptured; electrons are caused to leave their orbits. If most or all of the electrons leave their orbits, the gas fluid becomes plasma, which is very active chemically. The acceleration of nuclei in the dynamic condition can lead to nuclear reactions. In the pilot plant studies conducted at Research Triangle, NC, USA, for SO 2 conversion to SO 3 by rapid heating, a 10-ft high vertically fired combustor (VFC) was used. Air containing 0.5% SO 2 is forced continuously through the VFC, where it is heated by burners for conversion of SO 2 to SO 3 . During the idle period of operation, no external heat is added to the system by turning off the burners. It is observed that, as the air passing through the VFC during the idle period of sixteen hours, the temperature of the flowing air consistently rises up rapidly from ambient temperature (90 deg F) at inlet of the VFC to an average temperature as high as 582 deg F (in the range of 840 deg F to 455 deg F) at one section of the VFC, an increase of about 500 deg F. The air flow temperature increase of such large magnitude and long duration clearly indicates that nuclear reactions are present in VFC. It is also found that the water vapour in the air stream has completely disappeared in the VFC, for no sulphuric acid formation resulting from the reaction of water and SO 3 is detected there. Presumably, the water vapour in the

  10. A Novel Pharmacological Method to Study the Chinese Medicinal Formula Hua-Zheng-Hui-Sheng-Dan

    Rui Cao

    2015-01-01

    Full Text Available Objectives. Hua-Zheng-Hui-Sheng-Dan (HZHSD was used as an experimental model to explore research methods of large formulae in traditional Chinese medicine (TCM using current molecular biology approaches. Materials and Methods. The trypan blue exclusion assay was used to determine cell viability and cell numbers. Flow cytometry was used to assess cell cycle distribution and apoptosis. The concentration of cyclin D1 was analyzed by enzyme-linked immunosorbent assay. The median effect principle was used in drug combination studies. An orthogonal experimental design was used to estimate the effects of each herb at different concentrations. The HeLa xenograft mouse model was used to compare the antitumor activity of drugs in vivo. Results. Among the 35 herbs that comprise HZHSD, Radix Rehmanniae Preparata (RRP, Caesalpinia sappan (CS, Evodia rutaecarpa (ER, Folium Artemisiae Argyi (FAA, Leonurus japonicus Houtt (LJH, Tumeric (Tu, Radix Paeoniae Alba (RPA, and Trogopterus Dung (TD effectively inhibited the proliferation of HeLa and SKOV3 cells. Only RRR had an effect on HeLa and SKOV3 cell viability. According to the median effect principle, Angelica sinensis (Oliv. (AS, Tabanus (Ta, and Pollen Typhae (PT, which were proven to have a significant synergistic inhibitory effect on the proliferation of HeLa cells, were added to the original eight positive herbs. The combination of RPA and AS had a synergistic effect on inducing cell cycle S phase arrest and decreasing intracellular cyclin D1 in HeLa cells. By orthogonal experimental design, LJH and Tu were considered unnecessary herbs. The small formula (SHZHSD consisted of RPA, AS, RRR, Ta., TD, PT, ER, CS, and FAA and was able to inhibit cell proliferation and induce cell apoptosis. The antitumor effects of HZHSD and SHZHSD were also compared in vivo. Conclusions. Through molecular biology approaches both in vitro and in vivo, research into single drugs, and analysis using the median effect principle

  11. Dustfall design of open coal yard in the power plant-a case study on the closed reconstruction project of coal storage yard in shengli power plant

    Wang, Kunpeng; Ji, Weidong; Zhang, Feifei; Yu, Wei; Zheng, Runqing

    2018-02-01

    This thesis, based on the closed reconstruction project of the coal storage yard of Shengli Power Plant which is affiliated to Sinopec Shengli Petroleum Administration, first makes an analysis on the significance of current dustfall reconstruction of open coal yard, then summarizes the methods widely adopted in the dustfall of large-scale open coal storage yard of current thermal power plant as well as their advantages and disadvantages, and finally focuses on this project, aiming at providing some reference and assistance to the future closed reconstruction project of open coal storage yard in thermal power plant.

  12. 93 une urbanisation linéaire, dynamique demographique et ...

    Mohand

    d'Alger, dans l'ensemble Sahel-Mitidja sur un linéaire côtier de 2 km. Rattaché administrativement à la daira de ... connait une dynamique démographique remar- quable, dans sa périphérie orientale - composé de l'ensemble Sahel-. Mitidja ..... «Etude agro-pédologique de la plaine de la Mitidja». Florin B.; Semoud N. 2010.

  13. régression linéaire multiple

    Mots clés: Alcools et phénols – Représentation numérique de la structure chimique – Facteur acentrique – Régression linéaire multiple – Modèle RSP hybride. English Title: Structure / acentric factor relationship of alcohols and phenols: genetic algorithm – multiple linear regression approach. English Abstract. The acentric ...

  14. A Dynamic Attitude Measurement System Based on LINS

    Hanzhou Li

    2014-08-01

    Full Text Available A dynamic attitude measurement system (DAMS is developed based on a laser inertial navigation system (LINS. Three factors of the dynamic attitude measurement error using LINS are analyzed: dynamic error, time synchronization and phase lag. An optimal coning errors compensation algorithm is used to reduce coning errors, and two-axis wobbling verification experiments are presented in the paper. The tests indicate that the attitude accuracy is improved 2-fold by the algorithm. In order to decrease coning errors further, the attitude updating frequency is improved from 200 Hz to 2000 Hz. At the same time, a novel finite impulse response (FIR filter with three notches is designed to filter the dither frequency of the ring laser gyro (RLG. The comparison tests suggest that the new filter is five times more effective than the old one. The paper indicates that phase-frequency characteristics of FIR filter and first-order holder of navigation computer constitute the main sources of phase lag in LINS. A formula to calculate the LINS attitude phase lag is introduced in the paper. The expressions of dynamic attitude errors induced by phase lag are derived. The paper proposes a novel synchronization mechanism that is able to simultaneously solve the problems of dynamic test synchronization and phase compensation. A single-axis turntable and a laser interferometer are applied to verify the synchronization mechanism. The experiments results show that the theoretically calculated values of phase lag and attitude error induced by phase lag can both match perfectly with testing data. The block diagram of DAMS and physical photos are presented in the paper. The final experiments demonstrate that the real-time attitude measurement accuracy of DAMS can reach up to 20″ (1σ and the synchronization error is less than 0.2 ms on the condition of three axes wobbling for 10 min.

  15. A Dynamic Attitude Measurement System Based on LINS

    Li, Hanzhou; Pan, Quan; Wang, Xiaoxu; Zhang, Juanni; Li, Jiang; Jiang, Xiangjun

    2014-01-01

    A dynamic attitude measurement system (DAMS) is developed based on a laser inertial navigation system (LINS). Three factors of the dynamic attitude measurement error using LINS are analyzed: dynamic error, time synchronization and phase lag. An optimal coning errors compensation algorithm is used to reduce coning errors, and two-axis wobbling verification experiments are presented in the paper. The tests indicate that the attitude accuracy is improved 2-fold by the algorithm. In order to decrease coning errors further, the attitude updating frequency is improved from 200 Hz to 2000 Hz. At the same time, a novel finite impulse response (FIR) filter with three notches is designed to filter the dither frequency of the ring laser gyro (RLG). The comparison tests suggest that the new filter is five times more effective than the old one. The paper indicates that phase-frequency characteristics of FIR filter and first-order holder of navigation computer constitute the main sources of phase lag in LINS. A formula to calculate the LINS attitude phase lag is introduced in the paper. The expressions of dynamic attitude errors induced by phase lag are derived. The paper proposes a novel synchronization mechanism that is able to simultaneously solve the problems of dynamic test synchronization and phase compensation. A single-axis turntable and a laser interferometer are applied to verify the synchronization mechanism. The experiments results show that the theoretically calculated values of phase lag and attitude error induced by phase lag can both match perfectly with testing data. The block diagram of DAMS and physical photos are presented in the paper. The final experiments demonstrate that the real-time attitude measurement accuracy of DAMS can reach up to 20″ (1σ) and the synchronization error is less than 0.2 ms on the condition of three axes wobbling for 10 min. PMID:25177802

  16. lin-12 Notch functions in the adult nervous system of C. elegans

    Tucey Tim M

    2005-07-01

    Full Text Available Abstract Background Notch signaling pathways are conserved across species and traditionally have been implicated in cell fate determination during embryonic development. Notch signaling components are also expressed postdevelopmentally in the brains of adult mice and Drosophila. Recent studies suggest that Notch signaling may play a role in the physiological, rather than developmental, regulation of neurons. Here, we investigate a new non-developmental role for Caenorhabditis elegans lin-12 Notch signaling in neurons regulating the spontaneous reversal rate during locomotion. Results The spontaneous reversal rate of C. elegans during normal locomotion is constant. Both lin-12 gain and loss of function mutant animals had significantly increased reversal rates compared to wild type controls. These defects were caused by lin-12 activity, because the loss of function defect could be rescued by a wild type lin-12 transgene. Furthermore, overexpression of lin-12 recapitulated the gain-of-function defect. Increasing or decreasing lin-12 activity in the postdevelopmental adult animal was sufficient to rapidly and reversibly increase reversals, thereby excluding a developmental role for lin-12. Although lin-12 is expressed in the vulval and somatic gonad lineages, we find that these tissues play no role in regulating reversal rates. In contrast, altering lin-12 activity specifically in the nervous system was sufficient to increase reversals. These behavioral changes require components of the canonical lin-12 signaling cascade, including the ligand lag-2 and the transcriptional effector lag-1. Finally, the C. elegans AMPA/kainate glutamate receptor homolog glr-1 shows strong genetic interactions with lin-12, suggesting that glr-1 and/or other glutamate gated channels may be targets of lin-12 regulation. Conclusion Our results demonstrate a neuronal role for lin-12 Notch in C. elegans and suggest that lin-12 acutely regulates neuronal physiology to

  17. MYCN-driven regulatory mechanisms controlling LIN28B in neuroblastoma

    Beckers, Anneleen; Van Peer, Gert; Carter, Daniel R.; Gartlgruber, Moritz; Herrmann, Carl; Agarwal, Saurabh; Helsmoortel, Hetty H.; Althoff, Kristina; Molenaar, Jan J.; Cheung, Belamy B.; Schulte, Johannes H.; Benoit, Yves; Shohet, Jason M.; Westermann, Frank; Marshall, Glenn M.; Vandesompele, Jo; De Preter, Katleen; Speleman, Frank

    2016-01-01

    LIN28B has been identified as an oncogene in various tumor entities, including neuroblastoma, a childhood cancer that originates from neural crest-derived cells, and is characterized by amplification of the MYCN oncogene. Recently, elevated LIN28B expression levels were shown to contribute to neuroblastoma tumorigenesis via let-7 dependent de-repression of MYCN. However, additional insight in the regulation of LIN28B in neuroblastoma is lacking. Therefore, we have performed a comprehensive analysis of the regulation of LIN28B in neuroblastoma, with a specific focus on the contribution of miRNAs. We show that MYCN regulates LIN28B expression in neuroblastoma tumors via two distinct parallel mechanisms. First, through an unbiased LIN28B-3′UTR reporter screen, we found that miR-26a-5p and miR-26b-5p regulate LIN28B expression. Next, we demonstrated that MYCN indirectly affects the expression of miR-26a-5p, and hence regulates LIN28B, therefor establishing a MYCN-miR-26a-5p-LIN28B regulatory axis. Second, we provide evidence that MYCN regulates LIN28B expression via interaction with the LIN28B promotor, establishing a direct MYCN-LIN28B regulatory axis. We believe that these findings mark LIN28B as an important effector of the MYCN oncogenic phenotype and underlines the importance of MYCN-regulated miRNAs in establishing the MYCN-driven oncogenic process. PMID:26123663

  18. Refinements to calandria tube - liquid injection nozzle (CT-LIN) contact assessments

    Sedran, P.J.

    2012-01-01

    In recent years, the issue of CT-LIN contact, which first gained attention in 1989, has been addressed through CT-LIN gap measurements, followed by analytical predictions of time-to-contact. CT-LIN time-to-contact predictions have been preformed independently by CPUS Limited for Point Lepreau and Gentilly-2 and by AECL Sheridan Park (now Candu Energy Inc.) for Bruce Power and Gentilly-2. Both companies used the CDEPTH code in combination with CT-LIN gap measurements. Subsequent to the assessments for Point Lepreau and Gentilly-2, a recommended approach for future assessments was presented at the 2008 CANDU maintenance conference. Since that time, a number of refinements to the overall strategy for predicting CT-LIN time-to-contact have been developed and are outlined in this paper. The refinements include: 1. The use of ultrasonic LIN elevation measurements to confirm LIN creep sag behaviour 2. The development of a non-linear empirical CT Creep Sag Model 3. The development of a rationale for discrepancies observed in repeated optical CT-LIN gap measurements and a discussion of alternative CT-LIN gap measurements With these refinements, more accurate CT-LIN time-to-contact predictions can be obtained. For stations that plan to refurbish by 210,000 EFPH, the improvement in time-to-contact predictions resulting from the fore mentioned refinements will not be of any real benefit.. However, for stations that are planning life extensions in order to operate beyond 210,000 EFPH, CT-LIN contact will be an issue. For these stations, improvements in CT-LIN contact time predictions would be beneficial. This paper presents a summary of the proposed refinements and demonstrates how they would impact CT-LIN time-to-contact predictions. (author)

  19. Ge distribution in the Wulantuga high-germanium coal deposit in the Shengli coalfield, Inner Mongolia, northeastern China

    Du, Gang [Key Laboratory of Marginal Sea Geology, Chinese Academy of Sciences (China)]|[Coal Geology Bureau of Inner Mongolia, Hohhot, 010051 (China); Zhuang, Xinguo [Institute of Sedimentary Basin and Mineral, Faculty of Earth Resources, China University of Geosciences, Hubei, 430074 (China)]|[State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences, Hubei, 430074 (China); Querol, Xavier; Izquierdo, Maria; Alastuey, Andres; Moreno, Teresa; Font, Oriol [Institute of Earth Science ' Jaume Almera' , CSIC, C/ LLuis Sole Sabaris s/n, 08028 Barcelona (Spain)

    2009-03-01

    The geological and geochemical controls of the Ge distribution in the Cretaceous Wulantuga high-Germanium coal deposit in the Shengli coal field, Inner Mongolia are investigated. This paper focuses mainly on the spatial distribution of the Ge contents in coal. The high-Ge coals mainly occur in three splits of the 6 coal in the southwestern part of the Shengli coal field. Mean germanium contents in the coal range from 32 to 820 {mu}g/g, with a mean value of 137 {mu}g/g, on a bulk coal basis (mean of 939 coal samples from 75 boreholes in the 6 coal seam) in an area of 2.2 km{sup 2}. The highest Ge content occurs SW of 6 coal seam, close to the margins of the coal basin, decreasing with a fan-shaped trend towards NW, the direction of the coal basin. There is an negative correlation between the mean Ge content and the thickness of the coal seam. Different distribution patterns of Ge content were found in vertical profiles. High Ge concentrations may occur in the middle parts of coal seams, at the bottom and/or the top of thick coal seams and inconspicuous variation. A major organic affinity was determined for Ge, with a special enriched in the banded bright and semibright coal. The high-Ge coals and the coalified wood in the sandstone overlaying the 6-1 coal highly enriched in Ge, As, Sb, W, Cs, Tl, Be, and Hg. The Late Jurassic silicified volcanic rocks in the NW of the Ge coal deposit relatively high enriched in Ge, Ga, Sb, As, Cs, Be, Ge and Hg. The correlation coefficients among the elements enriched showed marked variations at close sites in this deposit, suggesting a possible diagenetic origin of the geochemical anomaly. The main Ge anomaly was attributed to early Cretaceous hydrothermal fluids circulating through the fault systems and porous volcanic rocs, probably from the subjacent granitoid rocks. The fault systems, the porous coarse clastic rocks overlying coal seam and the lithotype of coal played an important role in the transport and trapping of Ge. A

  20. Comparative analysis of the main bioactive components of Xin-Sheng-Hua granule and its single herbs by ultrahigh performance liquid chromatography with tandem mass spectrometry.

    Pang, Hanqing; Wang, Jun; Tang, Yuping; Xu, Huiqin; Wu, Liang; Jin, Yi; Zhu, Zhenhua; Guo, Sheng; Shi, Xuqin; Huang, Shengliang; Sun, Dazheng; Duan, Jin-Ao

    2016-11-01

    Xin-Sheng-Hua granule, a representative formula for postpartum hemorrhage, has been used clinically to treat postpartum diseases. Its main bioactive components comprise aromatic acids, phthalides, alkaloids, flavonoids, and gingerols among others. To investigate the changes in main bioactive constituents in its seven single herbs before and after compatibility, a rapid, simple, and sensitive method was developed for comparative analysis of 27 main bioactive components by using ultrahigh-performance liquid chromatography with triple quadrupole electrospray tandem mass spectrometry for the first time. The sufficient separation of 27 target constituents was achieved on a Thermo Scientific Hypersil GOLD column (100 mm × 3 mm, 1.9 μm) within 20 min under the optimized chromatographic conditions. Compared with the theoretical content, the observed content of each analyte showed remarkable differences in Xin-Sheng-Hua granule except thymine, p-coumaric acid, senkyunolide I, senkyunolide H, and ligustilide; the total contents of 27 components increased significantly, and the content variation degrees for the different components were gingerols > flavonoids > aromatic acids > alkaloids > phthalides. The results could provide a good reference for the quality control of Xin-Sheng-Hua granule and might be helpful to interpret the drug interactions based on variation of bioactive components in formulae. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. [Ecological vulnerability of coal mining area: a case study of Shengli Coalfield in Xilinguole of Inner Mongolia, China].

    Quan, Zhan-Jun; Li, Yuan; Li, Jun-Sheng; Han, Yu; Xiao, Neng-Wen; Fu, Meng-Di

    2013-06-01

    In this paper, an ecological vulnerability evaluation index system for the Shengli Coalfield in Xilinguole of Inner Mongolia was established, which included 16 factors in ecological sensitivity, natural and social pressure, and ecological recovery capacity, respectively. Based on the expert scoring method and analytic hierarchy process (AHP), an ecological vulnerability model was built for the calculation of the regional ecological vulnerability by means of RS and GIS spatial analysis. An analysis of the relationships between land use and ecological vulnerability was also made, and the results were tested by spatial auto-correlation analysis. Overall, the ecological vulnerability of the study area was at medium-high level. The exploitation of four opencast areas in the Coalfield caused a significant increase of ecological vulnerability. Moreover, due to the effects of mine drained water and human activities, the 300 -2000 m around the opencast areas was turning into higher ecologically fragile area. With further exploitation, the whole Coalfield was evolved into moderate and heavy ecological vulnerability area, and the coal resources mining was a key factor in this process. The cluster analysis showed that the spatial distribution of the ecological vulnerability in the study area had reasonable clustering characteristics. To decrease the population density, control the grazing capacity of grassland, and regulate the ratios of construction land and cultivated land could be the optimal ways for resolving the natural and social pressure, and to increase the investment and improve the vegetation recovery coefficient could be the fundamental measures for decreasing the ecological vulnerability of the study area.

  2. Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models

    Nguyen, Liem H.; Robinton, Daisy A.; Seligson, Marc; Wu, Linwei; Li, Lin; Rakheja, Dinesh; Comerford, Sarah; Ramezani, Saleh; Sun, Xiankai; Parikh, Monisha; Yang, Erin; Powers, John T.; Shinoda, Gen; Shah, Samar; Hammer, Robert; Daley, George Q.; Zhu, Hao

    2014-01-01

    SUMMARY Lin28a/b are RNA-binding proteins that influence stem cell maintenance, metabolism, and oncogenesis. Poorly differentiated, aggressive cancers often overexpress Lin28, but its role in tumor initiation or maintenance has not been definitively addressed. We report that LIN28B overexpression is sufficient to initiate hepatoblastoma and hepatocellular carcinoma in murine models. We also detected Lin28b overexpression in MYC-driven hepatoblastomas, and liver-specific deletion of Lin28a/b reduced tumor burden, extended latency, and prolonged survival. Both intravenous siRNA against Lin28b and conditional Lin28b deletion reduced tumor burden and prolonged survival. Igf2bp proteins are upregulated and Igf2bp3 is required in the context of LIN28B overexpression to promote growth. Thus, multiple murine models demonstrate that Lin28b is both sufficient to initiate liver cancer and necessary for its maintenance. PMID:25117712

  3. Metabolomics of hexachlorocyclohexane (HCH) transformation: ratio of LinA to LinB determines metabolic fate of HCH isomers.

    Geueke, Birgit; Garg, Nidhi; Ghosh, Sneha; Fleischmann, Thomas; Holliger, Christof; Lal, Rup; Kohler, Hans-Peter E

    2013-04-01

    Although the production and use of technical hexachlorocyclohexane (HCH) and lindane (the purified insecticidal isomer γ-HCH) are prohibited in most countries, residual concentrations still constitute an immense environmental burden. Many studies describe the mineralization of γ-HCH by bacterial strains under aerobic conditions. However, the metabolic fate of the other HCH isomers is not well known. In this study, we investigated the transformation of α-, β-, γ-, δ-, ε-HCH, and a heptachlorocyclohexane isomer in the presence of varying ratios of the two enzymes that initiate γ-HCH degradation, a dehydrochlorinase (LinA) and a haloalkane dehalogenase (LinB). Each substrate yielded a unique metabolic profile that was strongly dependent on the enzyme ratio. Comparison of these results to those of in vivo experiments with different bacterial isolates showed that HCH transformation in the tested strains was highly optimized towards productive metabolism of γ-HCH and that under these conditions other HCH-isomers were metabolized to mixtures of dehydrochlorinated and hydroxylated side-products. In view of these results, bioremediation efforts need very careful planning and toxicities of accumulating metabolites need to be evaluated. © 2012 Society for Applied Microbiology and Blackwell Publishing Ltd.

  4. Fetal deficiency of Lin28 programs life-long aberrations in growth and glucose metabolism

    Shinoda, Gen; Shyh-Chang, Ng; de Soysa, T. Yvanka; Zhu, Hao; Seligson, Marc T.; Shah, Samar P.; Abo-Sido, Nora; Yabuuchi, Akiko; Hagan, John P.; Gregory, Richard I.; Asara, John M.; Cantley, Lewis C.; Moss, Eric G.; Daley, George Q.

    2013-01-01

    LIN28A/B are RNA binding proteins implicated by genetic association studies in human growth and glucose metabolism. Mice with ectopic over-expression of Lin28a have shown related phenotypes. Here we describe the first comprehensive analysis of the physiologic consequences of Lin28a and Lin28b deficiency in knockout (KO) mice. Lin28a/b-deficiency led to dwarfism starting at different ages, and compound gene deletions showed a cumulative dosage effect on organismal growth. Conditional gene deletion at specific developmental stages revealed that fetal but neither neonatal nor adult deficiency resulted in growth defects and aberrations in glucose metabolism. Tissue-specific KO mice implicated skeletal muscle-deficiency in the abnormal programming of adult growth and metabolism. The effects of Lin28b KO can be rescued by Tsc1 haplo-insufficiency in skeletal muscles. Our data implicate fetal expression of Lin28a/b in the regulation of life-long effects on metabolism and growth, and demonstrate that fetal Lin28b acts at least in part via mTORC1 signaling. PMID:23666760

  5. Importance of the pluripotency factor LIN28 in the mammalian nucleolus during early embryonic development.

    Vogt, Edgar J; Meglicki, Maciej; Hartung, Kristina Ilka; Borsuk, Ewa; Behr, Rüdiger

    2012-12-01

    The maternal nucleolus is required for proper activation of the embryonic genome (EGA) and early embryonic development. Nucleologenesis is characterized by the transformation of a nucleolar precursor body (NPB) to a mature nucleolus during preimplantation development. However, the function of NPBs and the involved molecular factors are unknown. We uncover a novel role for the pluripotency factor LIN28, the biological significance of which was previously demonstrated in the reprogramming of human somatic cells to induced pluripotent stem (iPS) cells. Here, we show that LIN28 accumulates at the NPB and the mature nucleolus in mouse preimplantation embryos and embryonic stem cells (ESCs), where it colocalizes with the nucleolar marker B23 (nucleophosmin 1). LIN28 has nucleolar localization in non-human primate (NHP) preimplantation embryos, but is cytoplasmic in NHP ESCs. Lin28 transcripts show a striking decline before mouse EGA, whereas LIN28 protein localizes to NPBs at the time of EGA. Following knockdown with a Lin28 morpholino, the majority of embryos arrest between the 2- and 4-cell stages and never develop to morula or blastocyst. Lin28 morpholino-injected embryos arrested at the 2-cell stage were not enriched with nucleophosmin at presumptive NPB sites, indicating that functional NPBs were not assembled. Based on these results, we propose that LIN28 is an essential factor of nucleologenesis during early embryonic development.

  6. 107 Définition structurale des linéaments par traitement d'image ...

    Valued Packard Bell Customer

    The Ngovayang massif represents a key domain in understanding the geodynamics of the northern border of the Congo craton in South Cameroon. Remote sensing works .... linéaments liés au socle rocheux et aux accidents tectoniques (Minyem, 1994 [2]). Ces linéaments sont repartis selon trois directions. - la direction ...

  7. Experiences on reduction of reactor water silica and fresh resin leaching organics for Kuo-Sheng Nuclear Power Plant

    Wen, T-J.; Wang, C-H.

    2010-01-01

    The silica level in reactor water of Kuo-Sheng nuclear power plants has been slowly increased from 200 ppb to the high level above 500 ppb in recent years. The results obtained from steam/liquid mass balance calculation indicated that an increase of reactor water silica was mainly caused by continuing equilibrium leakage from deep bed condensate demineralizers, where the ion exchange zone was periodically disturbed by resin backwashing - scrubbing operation. The fastest and the most effective way to reduce the silica inventory in reactor system is to operate by continuously precoating of two sets of the reactor water clean up filter demineralizers to a lower effluent silica end point, and perhaps as frequently as three or four days. Leaching organic contaminants into feed water from the ion exchange resin becomes a key greater problem of current concern for the stable water quality promotion of condensate demineralizer. The presence of those impurities have practically been difficult to analyze by simple quality testing of the resin, and may result in as much as a hundred fold increase in chloride and sulfate in reactor water. As resin displacement with high leachable TOC, a repeated continuous soaking and effectively rinsing is required so that steady state TOC content less than 150 ppb should be achieved in an acceptably short period of time before put in-service. It is clear that cation resin containing high leachables generates high level of sulfates and sometimes also gives unexpected level of chlorides. The current TOC limits in condensate demineralizer effluent with 0.1 ppb become a significant experience to maintain reactor water soluble impurity in low levels. New resin should be subjected to TOC quality control testing prior to acceptance especially when first placed into service. TOC and organic chloride leachables for as-received virgin cation resin that are to be used in condensate polisher should be limited to be less than 100 mg-TOC and 0.5 mg-Cl per

  8. Regulation of C. elegans L4 cuticle collagen genes by the heterochronic protein LIN-29.

    Abete-Luzi, Patricia; Eisenmann, David M

    2018-05-01

    The cuticle, the outer covering of the nematode C. elegans, is synthesized five times during the worm's life by the underlying hypodermis. Cuticle collagens, the major cuticle component, are encoded by a large family of col genes and, interestingly, many of these genes express predominantly at a single developmental stage. This temporal preference motivated us to investigate the mechanisms underlying col gene expression and here we focus on a subset of col genes expressed in the L4 stage. We identified minimal promoter regions of <300 bp for col-38, col-49, and col-63. In these regions, we predicted cis-regulatory sequences and evaluated their function in vivo via mutagenesis of a col-38p::yfp reporter. We used RNAi to study the requirement for candidate transcription regulators ELT-1 and ELT-3, LIN-29, and the LIN-29 co-factor MAB-10, and found LIN-29 to be necessary for the expression of four L4-specific genes (col-38, col-49, col-63, and col-138). Temporal misexpression of LIN-29 was also sufficient to activate these genes at a different developmental stage. The LIN-29 DNA-binding domain bound the col-38, col-49, and col-63 minimal promoters in vitro. For col-38 we showed that the LIN-29 sites necessary for reporter expression in vivo are also bound in vitro: this is the first identification of specific binding sites for LIN-29 necessary for in vivo target gene expression. © 2018 Wiley Periodicals, Inc.

  9. In vitro expansion of Lin+ and Lin− mononuclear cells from human peripheral blood

    Norhaiza, H. Siti; Zarina, Z. A. Intan; Hisham, Z. A. Shahrul; Rohaya, M. A. W.

    2013-01-01

    Haematopoietic stem cells (HSCs) are used in the therapy of blood disorders due to the ability of these cells to reconstitute haematopoietic lineage cells when transplanted into myeloablative recipients. However, substantial number of cells is required in order for the reconstitution to take place. Since HSCs present in low frequency, larger number of donor is required to accommodate the demand of transplantable HSCs. Therefore, in vitro expansion of HSCs will have profound impact on clinical purposes. The aim of this study was to expand lineage negative (Lin − ) stem cells from human peripheral blood. Total peripheral blood mononuclear cells (PBMNCs) were fractionated from human blood by density gradient centrifugation. Subsequently, PBMNCs were subjected to magnetic assisted cell sorter (MACS) which depletes lineage positive (Lin + ) mononuclear cells expressing lineage positive markers such as CD2, CD3, CD11b, CD14, CD15, CD16, CD19, CD56, CD123, and CD235a to obtained Lin − cell population. The ability of Lin + and Lin − to survive in vitro was explored by culturing both cell populations in complete medium consisting of Alpha-Minimal Essential Medium (AMEM) +10% (v/v) Newborn Calf Serum (NBCS)+ 2% (v/v) pen/strep. In another experiment, Lin + and Lin − were cultured with complete medium supplemented with 10ng/mL of the following growth factors: stem cell factor (SCF), interleukin (IL)-3, granulocyte-macrophage colony stimulating factor (GM-CSF), 2IU/mL of Erythropoietin (Epo) and 20ng/mL of IL-6. Three samples were monitored in static culture for 22 days. The expansion potential was assessed by the number of total viable cells, counted by trypan blue exclusion assay. It was found that Lin + mononuclear cells were not able to survive either in normal proliferation medium or proliferation medium supplemented with cytokines. Similarly, Lin − stem cells were not able to survive in proliferation medium however, addition of cytokines into the proliferation

  10. Lin Receives 2010 Natural Hazards Focus Group Award for Graduate Research

    2010-11-01

    Ning Lin has been awarded the Natural Hazards Focus Group Award for Graduate Research, given annually to a recent Ph.D. recipient for outstanding contributions to natural hazards research. Lin's thesis is entitled “Multi-hazard risk analysis related to hurricanes.” She is scheduled to present an invited talk in the Extreme Natural Events: Modeling, Prediction, and Mitigation session (NH20) during the 2010 AGU Fall Meeting, held 13-17 December in San Francisco, Calif. Lin will be formally presented with the award at the Natural Hazards focus group reception on 14 December 2010.

  11. Lin28 Mediates Cancer Chemotherapy Resistance via Regulation of miRNA Signaling.

    Xu, Chaoyang; Xie, Shuduo; Song, Chunjiao; Huang, Liming; Jiang, Zhinong

    2014-06-01

    Chemotherapy resistance is one of the major obstacles limiting the success of cancer drug treatment. Among the mechanisms of resistance to chemotherapy treatment, there are those closely related to P-Glycoprotein, multidrug resistance-related protein, glutathione S-transferase pi and topoisomerase-II. Lin28 is a highly conserved RNA-binding protein, it consists of a cold shock domain and retroviral-type (CCHC) zinc finger motifs. In previous preclinical and clinical studies, positive Lin28 expression in cancer cells was correlated with decreased sensitivity to chemotherapy. And Lin28 could mediate cancer chemotherapy resistance via regulation of miR107 and Let-7 MiRNA. This article reviews current knowledge on predictive value of Lin28 in response to chemotherapy. Better understanding of its role may facilitate patient's selection of therapeutic regimen and lead to optimal clinical outcome.

  12. Lin28b stimulates the reprogramming of rat Müller glia to retinal progenitors

    Zhao, Chen; Tao, Zui; Xue, Langyue; Zeng, Yuxiao [Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing 400038 (China); Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing 400038 (China); Wang, Yi, E-mail: wangyieye@aliyun.com [Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing 400038 (China); Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing 400038 (China); Xu, Haiwei, E-mail: haiweixu2001@163.com [Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing 400038 (China); Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing 400038 (China); Yin, Zheng Qin, E-mail: qinzyin@aliyun.com [Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing 400038 (China); Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing 400038 (China)

    2017-03-01

    In lower-order vertebrates, Müller glia exhibit characteristics of retinal progenitor cells, while in higher vertebrates, such as mammals, the regenerative capacity of Müller glia is limited. Recently, we reported that Lin28b promoted the trans-differentiation of Müller cells to rod photoreceptor and bipolar cells in the retina of retinitis pigmentosa rat model, whereas it is unclear whether Lin28b can stimulate the reprogramming of Müller glia in vitro for transplantation into a damaged retina. In the present study, Long-Evens rat Müller glia were infected with Adeno-Lin28b or Adeno-GFP. Over-expression of Lin28b in isolated rat Müller glia resulted in the suppression of GFAP expression, enhancement of cell proliferation and a significant increase of the expression of retinal progenitor markers 5 days after infection. Moreover, Lin28b caused a significant reduction of the Let-7 family of microRNAs. Following sub-retinal space transplantation, Müller glia-derived retinal progenitors improved b-wave amplification of 30d Royal College of Surgeons retinitis pigmentosa model (RCS-P+) rats, as detected by electroretinography (ERG) recordings. Taken together, these data suggest that the up-regulation of Lin28b expression facilitated the reprogramming of Müller cells toward characteristics of retinal progenitors. - Highlights: • Lin28b reprograms Müller glia to retinal progenitors. • Let-7 micrRNAs are suppressed by Lin28b. • Transplantation of reprogrammed Müller glia restores retinal function.

  13. Lin28b stimulates the reprogramming of rat Müller glia to retinal progenitors

    Zhao, Chen; Tao, Zui; Xue, Langyue; Zeng, Yuxiao; Wang, Yi; Xu, Haiwei; Yin, Zheng Qin

    2017-01-01

    In lower-order vertebrates, Müller glia exhibit characteristics of retinal progenitor cells, while in higher vertebrates, such as mammals, the regenerative capacity of Müller glia is limited. Recently, we reported that Lin28b promoted the trans-differentiation of Müller cells to rod photoreceptor and bipolar cells in the retina of retinitis pigmentosa rat model, whereas it is unclear whether Lin28b can stimulate the reprogramming of Müller glia in vitro for transplantation into a damaged retina. In the present study, Long-Evens rat Müller glia were infected with Adeno-Lin28b or Adeno-GFP. Over-expression of Lin28b in isolated rat Müller glia resulted in the suppression of GFAP expression, enhancement of cell proliferation and a significant increase of the expression of retinal progenitor markers 5 days after infection. Moreover, Lin28b caused a significant reduction of the Let-7 family of microRNAs. Following sub-retinal space transplantation, Müller glia-derived retinal progenitors improved b-wave amplification of 30d Royal College of Surgeons retinitis pigmentosa model (RCS-P+) rats, as detected by electroretinography (ERG) recordings. Taken together, these data suggest that the up-regulation of Lin28b expression facilitated the reprogramming of Müller cells toward characteristics of retinal progenitors. - Highlights: • Lin28b reprograms Müller glia to retinal progenitors. • Let-7 micrRNAs are suppressed by Lin28b. • Transplantation of reprogrammed Müller glia restores retinal function.

  14. Le nævus épidermique verruqueux inflammatoire linéaire ...

    Le nævus épidermique verruqueux inflammatoire linéaire (NEVIL) est une affection rare correspondant à des hyperplasies épidermiques bénignes qui se présentent cliniquement sous forme de lésions linéaires unilatérales hyperkératosiques. Une adolescente âgée de 16 ans, sans antécédents, présentait depuis la ...

  15. Effectiveness of Traditional Chinese Medicine Compound JieDuTongLuoShengJin Granules Treatment in Primary Sjögren’s Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

    Ben Li

    2017-01-01

    Full Text Available Objective. To evaluate the clinical therapeutic efficacy and safety of JieDuTongLuoShengJin granules + HCQ in patients with pSS. Methods. 40 patients with low-activity-level pSS and without visceral involvement participated in this study and were randomized to receive either JieDuTongLuoShengJin granules with HCQ or placebo with HCQ. Patients and investigators were blinded to treatment allocation. The primary endpoint was week 12 ESSPRI score, while secondary endpoints included ESSDAI, salivary and lacrimal gland function, and some laboratory variables. Safety-related data were also assessed. Results. Comparing with the placebo group, the treatment group experienced statistically significant improvement in the mean change from baseline for the primary endpoint of ESSPRI score and also in PGA. Moreover, in comparison with baseline values, the treatment group had significantly improved ESSDAI score, unstimulated saliva flow rate, and several laboratory variables. However, upon comparison of the two groups, there were no significant differences for them. The incidence of AEs was 10.0%, one in treatment group and three in placebo group. Conclusion. Treatment with a combination of JieDuTongLuoShengJin granules with HCQ is effective in improving patients’ subjective symptoms and some objective indicators of pSS. These results indicate that JieDuTongLuoShengJin is promising as a safe and effective treatment of pSS.

  16. Redescription of the types of species of Anastatus Motschulsky, 1859 (Hymenoptera: Chalcidoidea: Eupelmidae described by J.K. Sheng and coauthors

    Lingfei Peng

    2017-03-01

    Full Text Available Six species of Anastatus Motschulsky, 1859 (Hymenoptera: Eupelmidae were described from China in Chinese by J.K. Sheng and coauthors in 1997 and 1998: A. dexingensis, A. flavipes, A. fulloi, A. huangi, A. meilingensis and A. shichengensis. This represents almost half the species of Anastatus recorded from China, but no keys were given to differentiate the species and the original descriptions included only simple line drawings to illustrate the species. Because recognition of these species is critical prior to clarifying the Anastatus fauna of China and of the eastern Palaearctic and Oriental regions, we have redescribed the six species in detail in English based on original type material, illustrating the species through macrophotography of type material and providing a key to differentiate females of the species.

  17. Association of Lin-28A rs3811464 Variant with Susceptibility to Type 2 Diabetes

    Mona Khodabandeh

    2017-11-01

    Full Text Available Introduction: It has been suggested that Lin-28A and the let-7 microRNA family (Lin-28/let-7 axis play a critical role in the control of glucose metabolism, insulin sensitivity and resistance to diabetes. Aim: This case-control study aimed at evaluating the association between Lin-28 rs3811464 polymorphism and the susceptibility to Type 2 Diabetes (T2D in a sample of Iranian population. Materials and Methods: This study involved 172 T2D patients and 160 non-diabetic age and gender-matched controls. Lin 28A rs3811464 genotypes were determined by Polymerase Chain Reaction–Restriction Fragment Length Polymorphism (PCR-RFLP technique. Results: The results showed that the frequency of the AA genotype was significantly higher in control subjects than in diabetic patients (13.12% vs. 4.65%. In addition, binary logistic regression analysis revealed that rs3811464-AA genotype was significantly associated to T2D after adjustment for BMI, age and lipid profiles. Indeed, subjects with AA genotype were less likely to develop T2D than GG and AG subjects (OR of 0.26, 95% CI 0.10-0.66, p=0.005. Conclusion: The findings of our study suggest that the Lin 28A rs3811464 is associated with type 2 diabetes susceptibility and subjects with AA genotypes were less likely to develop T2D diabetes.

  18. Clinical application of Lin's biopsy grasper for intrauterine targeted biopsy and polypectomy during office hysteroscopy.

    Cheng, Hsin-Yi; Lin, Bao-Liang; Tseng, Jen-Yu; Ueno, Kazunori; Nakada, Sakura

    2018-06-01

    Hysteroscopy has widely been used for diagnosis of the uterine cavity; however, target biopsy has often been difficult in part to the inherent limitations of ancillary instruments. Lin's biopsy grasper was specifically designed to work in conjunction with a flexible hysteroscope to obtain intrauterine biopsy under transabdominal sonography. Herein, we share our clinical experience in the management of endometrial abnormalities with the use of Lin's biopsy grasper during office-based hysteroscopy. From February 2006 to November 2016, the use of Lin's biopsy grasper for tissue biopsy was attempted on 126 cases. We retrospectively recorded and analyzed the patients' preoperative characteristics and biopsy outcomes to demonstrate the feasibility and efficacy of Lin's biopsy grasper. Out of the one hundred and twenty-six enrolled patients, satisfactory targeted biopsies were achieved; including high diagnostic rate (92.1%, with 116 cases confirmed histologically) and adequate tissue retrieval (77.8%, with 98 cases obtaining optimal specimen volume). All patients tolerated the procedure without analgesics or anesthesia. Diagnostic flexible hysteroscopy combined with the use of Lin's biopsy grasper has proven to be an effective tool for intrauterine evaluation and obtaining tissue sample. Copyright © 2018. Published by Elsevier B.V.

  19. Lin4Neuro: a customized Linux distribution ready for neuroimaging analysis.

    Nemoto, Kiyotaka; Dan, Ippeita; Rorden, Christopher; Ohnishi, Takashi; Tsuzuki, Daisuke; Okamoto, Masako; Yamashita, Fumio; Asada, Takashi

    2011-01-25

    A variety of neuroimaging software packages have been released from various laboratories worldwide, and many researchers use these packages in combination. Though most of these software packages are freely available, some people find them difficult to install and configure because they are mostly based on UNIX-like operating systems. We developed a live USB-bootable Linux package named "Lin4Neuro." This system includes popular neuroimaging analysis tools. The user interface is customized so that even Windows users can use it intuitively. The boot time of this system was only around 40 seconds. We performed a benchmark test of inhomogeneity correction on 10 subjects of three-dimensional T1-weighted MRI scans. The processing speed of USB-booted Lin4Neuro was as fast as that of the package installed on the hard disk drive. We also installed Lin4Neuro on a virtualization software package that emulates the Linux environment on a Windows-based operation system. Although the processing speed was slower than that under other conditions, it remained comparable. With Lin4Neuro in one's hand, one can access neuroimaging software packages easily, and immediately focus on analyzing data. Lin4Neuro can be a good primer for beginners of neuroimaging analysis or students who are interested in neuroimaging analysis. It also provides a practical means of sharing analysis environments across sites.

  20. LIN-32/Atonal Controls Oxygen Sensing Neuron Development in Caenorhabditis elegans

    Romanos, Teresa Rojo; Pladevall-Morera, David; Langebeck-Jensen, Kasper

    2017-01-01

    HLH) family of transcription factors has multiple functions in neurogenesis. Here, we identified the LIN-32/Atonal bHLH transcription factor as a key regulator of URXL/R oxygen-sensing neuron development in Caenorhabditis elegans. When LIN-32/Atonal expression is lost, the expression of URX specification......Development of complex nervous systems requires precisely controlled neurogenesis. The generation and specification of neurons occur through the transcriptional and post-Transcriptional control of complex regulatory networks. In vertebrates and invertebrates, the proneural basic-helix-loop-helix (b...... and terminal differentiation genes is abrogated. As such, lin-32 mutant animals are unable to respond to increases in environmental oxygen. The URX neurons are generated from a branch of the cell lineage that also produces the CEPDL/R and URADL/R neurons. We found development of these neurons is also defective...

  1. Identification and Characterization of Genes That Interact with Lin-12 in Caenorhabditis Elegans

    Tax, F. E.; Thomas, J. H.; Ferguson, E. L.; Horvitz, H. R.

    1997-01-01

    We identified and characterized 14 extragenic mutations that suppressed the dominant egg-laying defect of certain lin-12 gain-of-function mutations. These suppressors defined seven genes: sup-17, lag-2, sel-4, sel-5, sel-6, sel-7 and sel-8. Mutations in six of the genes are recessive suppressors, whereas the two mutations that define the seventh gene, lag-2, are semi-dominant suppressors. These suppressor mutations were able to suppress other lin-12 gain-of-function mutations. The suppressor ...

  2. [Professor LIN Guohua's experience of gold implantation at acupoint for rheumatoid arthritis].

    Li, Jingjing; Pei, Wenya

    2015-12-01

    Based on the pathogenesis and symptom of rheumatoid arthritis (RA), professor LIN Guohua's unique opinion and method for RA in clinical treatment are summarized and analyzed. In the opinion of Professor Lin, RA is considered as "Jinbi" and "Gubi" in TCM, which is caused by deficient root with superficial excess. Based on the symptoms of RA, attention should be focused on lung-kidney diagnosis and treatment, and gold and catgut implantation at acupoint can be mutually combined, which is aimed to provide a special and effective method for clinical treatment of RA.

  3. Multiple transcription factors directly regulate Hox gene lin-39 expression in ventral hypodermal cells of the C. elegans embryo and larva, including the hypodermal fate regulators LIN-26 and ELT-6.

    Liu, Wan-Ju; Reece-Hoyes, John S; Walhout, Albertha J M; Eisenmann, David M

    2014-05-13

    Hox genes encode master regulators of regional fate specification during early metazoan development. Much is known about the initiation and regulation of Hox gene expression in Drosophila and vertebrates, but less is known in the non-arthropod invertebrate model system, C. elegans. The C. elegans Hox gene lin-39 is required for correct fate specification in the midbody region, including the Vulval Precursor Cells (VPCs). To better understand lin-39 regulation and function, we aimed to identify transcription factors necessary for lin-39 expression in the VPCs, and in particular sought factors that initiate lin-39 expression in the embryo. We used the yeast one-hybrid (Y1H) method to screen for factors that bound to 13 fragments from the lin-39 region: twelve fragments contained sequences conserved between C. elegans and two other nematode species, while one fragment was known to drive reporter gene expression in the early embryo in cells that generate the VPCs. Sixteen transcription factors that bind to eight lin-39 genomic fragments were identified in yeast, and we characterized several factors by verifying their physical interactions in vitro, and showing that reduction of their function leads to alterations in lin-39 levels and lin-39::GFP reporter expression in vivo. Three factors, the orphan nuclear hormone receptor NHR-43, the hypodermal fate regulator LIN-26, and the GATA factor ELT-6 positively regulate lin-39 expression in the embryonic precursors to the VPCs. In particular, ELT-6 interacts with an enhancer that drives GFP expression in the early embryo, and the ELT-6 site we identified is necessary for proper embryonic expression. These three factors, along with the factors ZTF-17, BED-3 and TBX-9, also positively regulate lin-39 expression in the larval VPCs. These results significantly expand the number of factors known to directly bind and regulate lin-39 expression, identify the first factors required for lin-39 expression in the embryo, and hint at a

  4. Influence of Partial Dam Removal on Change of Channel Morphology and Physical Habitats: A Case Study of Yu-Sheng River

    Hao Weng, Chung; Yeh, Chao Hsien

    2017-04-01

    The rivers in Taiwan have the characteristic of large slope gradient and fast flow velocity caused by rugged terrain. And Taiwan often aces many typhoons which will bring large rainfall in the summer. In early Taiwan, river management was more focus on flood control, flood protection and disaster reduction. In recent years, the rise of ecological conservation awareness for the precious fish species brings spotlight on the Taiwan salmon (Oncorhynchus masou formosanus) which lives in the river section of this study. In order to make sure ecological corridor continuing, dam removal is the frequently discussed measure in recent years and its impact on environmental is also highly concerned. Since the dam removal may causes severe changes to the river channel, the action of dam removal needs careful evaluation. As one of the endangered species, Taiwan salmon is considered a national treasure of Taiwan and it was originally an offshore migration of the Pacific salmon. After the ice age and geographical isolation, it becomes as an unique subspecies of Taiwan and evolved into landlocked salmon. Now the Taiwan salmon habitats only exists in few upstream creeks and the total number of wild Taiwan salmon in 2015 was about 4,300. In order to expand the connectivity of the fish habitats in Chi-Jia-Wan creek basin, several dam removal projects had completed with good results. Therefore, this paper focuses on the dam removal of Yu-Sheng creek dam. In this paper, a digital elevation model (DEM) of about 1 kilometer channel of the Yu-Sheng creek dam is obtained by unmanned aerial vehicle (UAV). Using CCHE2D model, the simulation of dam removal will reveal the impact on channel morphology. After model parameter identification and verification, this study simulated the scenarios of three historical typhoon events with recurrence interval of two years, fifteen years, and three decades under four different patterns of dam removal to identify the the head erosion, flow pattern, and

  5. Kinetic and sequence-structure-function analysis of known LinA variants with different hexachlorocyclohexane isomers.

    Pooja Sharma

    Full Text Available BACKGROUND: Here we report specific activities of all seven naturally occurring LinA variants towards three different isomers, α, γ and δ, of a priority persistent pollutant, hexachlorocyclohexane (HCH. Sequence-structure-function differences contributing to the differences in their stereospecificity for α-, γ-, and δ-HCH and enantiospecificity for (+- and (--α -HCH are also discussed. METHODOLOGY/PRINCIPAL FINDINGS: Enzyme kinetic studies were performed with purified LinA variants. Models of LinA2(B90A A110T, A111C, A110T/A111C and LinA1(B90A were constructed using the FoldX computer algorithm. Turnover rates (min(-1 showed that the LinAs exhibited differential substrate affinity amongst the four HCH isomers tested. α-HCH was found to be the most preferred substrate by all LinA's, followed by the γ and then δ isomer. CONCLUSIONS/SIGNIFICANCE: The kinetic observations suggest that LinA-γ1-7 is the best variant for developing an enzyme-based bioremediation technology for HCH. The majority of the sequence variation in the various linA genes that have been isolated is not neutral, but alters the enantio- and stereoselectivity of the encoded proteins.

  6. An Effective Implementation of K-opt Moves for the Lin-Kernighan TSP Heuristic

    Helsgaun, Keld

    Local search with k-change neighborhoods, k-opt, is the most widely used heuristic method for the traveling salesman problem (TSP). This report presents an effective implementation of k-opt for the Lin- Kernighan TSP heuristic. The effectiveness of the implementation is demonstrated with extensive...

  7. Combustion of Pure, Hydrolyzed and Methyl Ester Formed of Jatropha Curcas Lin oil

    Muhaji Muhaji

    2015-10-01

    Full Text Available The density and viscosity of vegetable oil are higher than that of diesel oil. Thus its direct combustion in the diesel engine results many problems. This research was conducted to investigate the flame characteristics of combustion of jatropha curcas lin in pure, hydrolyzed and methyl ester form. The results indicated that the combustion of pure jatropha curcas lin occurs in three stages, hydrolyzed in two stages    and methyl ester in one stage. For pure jatropha curcas lin, in the first stage, unsaturated fatty acid burned for  0.265 s.  It is followed by saturated fatty acid, burned for 0.389 s in the second stage. And, in the last stage is the burned of glycerol for 0.560 s. Meanwhile for hydrolyzed one, in the first stage, unsaturated fatty acid burned for 0.736 s, followed by saturated fatty acid, burned  for 0.326 s in the second stage. And the last, for methyl ester is the burned for 0.712 s. The highest burning rate was for methyl ester which was 0.003931cc/s. The energy releasing rate of methyl ester, which was for 13,628.67 kcal/(kg.s resembled that of diesel oil the most, while the lowest rate was for pure jatropha curcas lin which was 8,200.94 kcal/(kg.s. In addition, massive explosion occurred in the fuel containing unsaturated fatty acid and glycerol

  8. linäituse stendid = Outdoor exhibition stands / Gert Sarv, Galina Burnakova

    Sarv, Gert, 1971-

    2013-01-01

    Eesti Sisearhitektide Liidu 2012. aasta parima eseme preemia pälvinud välinäituse stendidest Vanasadama Admiraliteedi basseini kaldapealsel. Autorid: Gert Sarv, Galina Burnakova, Loreida Hein. Sisearhitekti ja ESLi aastapreemiate žürii liikme Tea Tammelaane arvamus

  9. A role for Lin28 in primordial germ cell development and germ cell malignancy

    West, Jason A.; Viswanathan, Srinivas R.; Yabuuchi, Akiko; Cunniff, Kerianne; Takeuchi, Ayumu; Park, In-Hyun; Sero, Julia E.; Zhu, Hao; Perez-Atayde, Antonio; Frazier, A. Lindsay; Surani, M. Azim; Daley, George Q.

    2009-01-01

    The rarity and inaccessibility of the earliest primordial germ cells (PGCs) in the mouse embryo thwarts efforts to investigate molecular mechanisms of germ cell specification. Stella marks the minute founder population of the germ lineage1,2. Here we differentiate mouse embryonic stem cells (ESCs) carrying a Stella transgenic reporter into putative PGCs in vitro. The Stella+ cells possess a transcriptional profile similar to embryo-derived PGCs, and like their counterparts in vivo, lose imprints in a time-dependent manner. Using inhibitory RNAs to screen candidate genes for effects on the development of Stella+ cells in vitro, we discovered that Lin28, a negative regulator of let-7 microRNA processing3-6, is essential for proper PGC development. We further show that Blimp1, a let-7 target and a master regulator of PGC specification7-9, can rescue the effect of Lin28-deficiency during PGC development, thereby establishing a mechanism of action for Lin28 during PGC specification. Over-expression of Lin28 promotes formation of Stella+ cells in vitro and PGCs in chimeric embryos, and is associated with human germ cell tumours. The differentiation of putative PGCs from ESCs in vitro recapitulates the early stages of gamete development in vivo, and provides an accessible system for discovering novel genes involved in germ cell development and malignancy. PMID:19578360

  10. Cryptanalysis of Lin et al.'s Efficient Block-Cipher-Based Hash Function

    Liu, Bozhong; Gong, Zheng; Chen, Xiaohong; Qiu, Weidong; Zheng, Dong

    2010-01-01

    Hash functions are widely used in authentication. In this paper, the security of Lin et al.'s efficient block-cipher-based hash function is reviewed. By using Joux's multicollisions and Kelsey et al.'s expandable message techniques, we find the scheme is vulnerable to collision, preimage and second

  11. Single-tube linear DNA amplification (LinDA) for robust ChIP-seq

    Shankaranarayanan, P.; Mendoza-Parra, M.A.; Walia, M.; Wang, L.; Li, N.; Trindade, L.M.; Gronemeyer, H.

    2011-01-01

    Genome-wide profiling of transcription factors based on massive parallel sequencing of immunoprecipitated chromatin (ChIP-seq) requires nanogram amounts of DNA. Here we describe a high-fidelity, single-tube linear DNA amplification method (LinDA) for ChIP-seq and reChIP-seq with picogram DNA amounts

  12. New explicit and exact solutions of the Benney–Kawahara–Lin equation

    Yuan-Xi, Xie

    2009-01-01

    In this paper, we present a combination method of constructing the explicit and exact solutions of nonlinear partial differential equations. And as an illustrative example, we apply the method to the Benney–Kawahara–Lin equation and derive its many explicit and exact solutions which are all new solutions. (general)

  13. Variational principles of fluid mechanics and electromagnetism: imposition and neglect of the Lin constraint

    Allen, R.R. Jr.

    1987-01-01

    The Lin constraint has been utilized by a number of authors who have sought to develop Eulerian variational principles in both fluid mechanics and electromagnetics (or plasmadynamics). This dissertation first reviews the work of earlier authors concerning the development of variational principles in both the Eulerian and Lagrangian nomenclatures. In the process, it is shown whether or not the Euler-Lagrange equations that result from the variational principles are equivalent to the generally accepted equations of motion. In particular, it is shown in the case of several Eulerian variational principles that imposition of the Lin constraint results in Euler-Lagrange equations equivalent to the generally accepted equations of motion, whereas neglect of the Lin constraint results in restrictive Euler-Lagrange equations. In an effort to improve the physical motivation behind introduction of the Lin constraint, a new variational constraint is developed based on teh concept of surface forces within a fluid. Additionally, it is shown that a quantity often referred to as the canonical momentum of a charged fluid is not always a constant of the motion of the fluid; and it is demonstrated that there does not exist an unconstrained Eulerian variational principle giving rise to the generally accepted equations of motion for both a perfect fluid and a cold, electromagnetic fluid

  14. A Systems Biology-Based Investigation into the Pharmacological Mechanisms of Sheng-ma-bie-jia-tang Acting on Systemic Lupus Erythematosus by Multi-Level Data Integration.

    Huang, Lin; Lv, Qi; Liu, Fenfen; Shi, Tieliu; Wen, Chengping

    2015-11-12

    Sheng-ma-bie-jia-tang (SMBJT) is a Traditional Chinese Medicine (TCM) formula that is widely used for the treatment of Systemic Lupus Erythematosus (SLE) in China. However, molecular mechanism behind this formula remains unknown. Here, we systematically analyzed targets of the ingredients in SMBJT to evaluate its potential molecular mechanism. First, we collected 1,267 targets from our previously published database, the Traditional Chinese Medicine Integrated Database (TCMID). Next, we conducted gene ontology and pathway enrichment analyses for these targets and determined that they were enriched in metabolism (amino acids, fatty acids, etc.) and signaling pathways (chemokines, Toll-like receptors, adipocytokines, etc.). 96 targets, which are known SLE disease proteins, were identified as essential targets and the rest 1,171 targets were defined as common targets of this formula. The essential targets directly interacted with SLE disease proteins. Besides, some common targets also had essential connections to both key targets and SLE disease proteins in enriched signaling pathway, e.g. toll-like receptor signaling pathway. We also found distinct function of essential and common targets in immune system processes. This multi-level approach to deciphering the underlying mechanism of SMBJT treatment of SLE details a new perspective that will further our understanding of TCM formulas.

  15. Biodegradation of γ-hexachlorocyclohexane by transgenic hairy root cultures of Cucurbita moschata that accumulate recombinant bacterial LinA.

    Nanasato, Yoshihiko; Namiki, Sayuri; Oshima, Masao; Moriuchi, Ryota; Konagaya, Ken-Ichi; Seike, Nobuyasu; Otani, Takashi; Nagata, Yuji; Tsuda, Masataka; Tabei, Yutaka

    2016-09-01

    γ-HCH was successfully degraded using LinA-expressed transgenic hairy root cultures of Cucurbita moschata . Fusing an endoplasmic reticulum-targeting signal peptide to LinA was essential for stable accumulation in the hairy roots. The pesticide γ-hexachlorocyclohexane (γ-HCH) is a persistent organic pollutant (POP) that raises public health and environmental pollution concerns worldwide. Although several isolates of γ-HCH-degrading bacteria are available, inoculating them directly into γ-HCH-contaminated soil is ineffective because of the bacterial survival rate. Cucurbita species incorporate significant amounts of POPs from soils compared with other plant species. Here, we describe a novel bioremediation strategy that combines the bacterial degradation of γ-HCH and the efficient uptake of γ-HCH by Cucurbita species. We produced transgenic hairy root cultures of Cucurbita moschata that expressed recombinant bacterial linA, isolated from the bacterium Sphingobium japonicum UT26. The LinA protein was accumulated stably in the hairy root cultures by fusing an endoplasmic reticulum (ER)-targeting signal peptide to LinA. Then, we demonstrated that the cultures degraded more than 90 % of γ-HCH (1 ppm) overnight and produced the γ-HCH metabolite 1,2,4-trichlorobenzene, indicating that LinA degraded γ-HCH. These results indicate that the gene linA has high potential for phytoremediation of environmental γ-HCH.

  16. LIN28 phosphorylation by MAPK/ERK couples signaling to the post-transcriptional control of pluripotency

    Tsanov, Kaloyan M.; Pearson, Daniel S.; Wu, Zhaoting; Han, Areum; Triboulet, Robinson; Seligson, Marc T.; Powers, John T.; Osborne, Jihan K.; Kane, Susan; Gygi, Steven P.; Gregory, Richard I.; Daley, George Q.

    2016-01-01

    Signaling and post-transcriptional gene control are both critical for the regulation of pluripotency1,2, yet how they are integrated to influence cell identity remains poorly understood. LIN28 (also known as LIN28A), a highly conserved RNA-binding protein (RBP), has emerged as a central post-transcriptional regulator of cell fate through blockade of let-7 microRNA (miRNA) biogenesis and direct modulation of mRNA translation3. Here we show that LIN28 is phosphorylated by MAPK/ERK in pluripotent stem cells (PSCs), which increases its levels via post-translational stabilization. LIN28 phosphorylation had little impact on let-7 but enhanced LIN28’s effect on its direct mRNA targets, revealing a mechanism that uncouples LIN28’s let-7-dependent and independent activities. We have linked this mechanism to the induction of pluripotency by somatic cell reprogramming and the transition from naïve to primed pluripotency. Collectively, our findings indicate that MAPK/ERK directly impacts LIN28, defining an axis that connects signaling, post-transcriptional gene control, and cell fate regulation. PMID:27992407

  17. The let-7/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury.

    McDaniel, Kelly; Huang, Li; Sato, Keisaku; Wu, Nan; Annable, Tami; Zhou, Tianhao; Ramos-Lorenzo, Sugeily; Wan, Ying; Huang, Qiaobing; Francis, Heather; Glaser, Shannon; Tsukamoto, Hidekazu; Alpini, Gianfranco; Meng, Fanyin

    2017-07-07

    The let-7/Lin28 axis is associated with the regulation of key cellular regulatory genes known as microRNAs in various human disorders and cancer development. This study evaluated the role of the let-7/Lin28 axis in regulating a mesenchymal phenotype of hepatic stellate cells in alcoholic liver injury. We identified that ethanol feeding significantly down-regulated several members of the let-7 family in mouse liver, including let-7a and let-7b. Similarly, the treatment of human hepatic stellate cells (HSCs) with lipopolysaccharide (LPS) and transforming growth factor-β (TGF-β) significantly decreased the expressions of let-7a and let-7b. Conversely, overexpression of let-7a and let-7b suppressed the myofibroblastic activation of cultured human HSCs induced by LPS and TGF-β, as evidenced by repressed ACTA2 (α-actin 2), COL1A1 (collagen 1A1), TIMP1 (TIMP metallopeptidase inhibitor 1), and FN1 (fibronectin 1); this supports the notion that HSC activation is controlled by let-7. A combination of bioinformatics, dual-luciferase reporter assay, and Western blot analysis revealed that Lin28B and high-mobility group AT-hook (HMGA2) were the direct targets of let-7a and let-7b. Furthermore, Lin28B deficiency increased the expression of let-7a/let-7b as well as reduced HSC activation and liver fibrosis in mice with alcoholic liver injury. This feedback regulation of let-7 by Lin28B is verified in hepatic stellate cells isolated by laser capture microdissection from the model. The identification of the let-7/Lin28 axis as an important regulator of HSC activation as well as its upstream modulators and down-stream targets will provide insights into the involvement of altered microRNA expression in contributing to the pathogenesis of alcoholic liver fibrosis and novel therapeutic approaches for human alcoholic liver diseases. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  18. Lin28a uses distinct mechanisms of binding to RNA and affects miRNA levels positively and negatively

    Nowak, Jakub Stanislaw; Hobor, Fruzsina; Downie Ruiz Velasco, Angela; Choudhury, Nila Roy; Heikel, Gregory; Kerr, Alastair; Ramos, Andres; Michlewski, Gracjan

    2017-01-01

    Lin28a inhibits the biogenesis of let-7 miRNAs by triggering the polyuridylation and degradation of their precursors by terminal uridylyltransferases TUT4/7 and 3’-5’ exoribonuclease Dis3l2, respectively. Previously, we showed that Lin28a also controls the production of neuro-specific miRNA-9 via a polyuridylation-independent mechanism. Here we reveal that the sequences and structural characteristics of pre-let-7 and pre-miRNA-9 are eliciting two distinct modes of binding to Lin28a. We presen...

  19. Fragmented Encounters, Social Slippages: Lin Huiyin's "In Ninety-Nine Degree Heat"

    Carles Prado-Fonts

    2010-01-01

    Full Text Available The article reads Lin Huiyin’s short story “In Ninety-Nine Degree Heat” (1934 in relation to the context of 1930s China, as an innovative literary work which combines elements from both the Chinese and the Western traditions, and as a text which informs readers not only of the problematic of class and gender issues in 1930s Chinese society but also of the context of the liuxuesheng who returns to China –like Lin Huiyin herself. Focusing on questions like otherness, representation, and encounters, the essay analyzes how the episodic narrative structure of Lin’s short story echoes social and representational discourses in post-May Fourth China, at the same time that it explores issues such as social inequality, otherness and alienation, which were crucial to the liuxuesheng, and which reflect Lin’s own experience as a returned and alienated liuxuesheng at the time.

  20. GENII-LIN: a Multipurpose Health Physics Code Built on GENII-1.485

    Marco Sumini

    2006-10-01

    Full Text Available The aim of the GENII-LIN project was to develop an open source multipurpose health physics code running on Linux platform, for calculating radiation dose and risk from radionuclides released to the environment. The general features of the GENII-LIN system include [1] capabilities for calculating radiation dose both for acute and chronic releases, with options for annual dose, committed dose and accumulated dose [2] capabilities for evaluating exposure pathways including direct exposure via water (swimming, boating, fishing, soil (buried and surface sources and air (semi-infinite cloud and finite cloud model, inhalation pathways and ingestion pathways. The release scenarios considered are: - acute release to air, from ground level or elevated sources, or to water; - chronic release to air, from ground level or elevated sources, or to water; - initial contamination of soil or surfaces. Keywords: radiation protection, Linux, health physics, risk analysis.

  1. An Adaptation of the Kernighan-Lin Heuristic to the Simple Graph Partitioning Problem

    Sørensen, Michael Malmros

    1999-01-01

    to this problem of the Kernighan-Lin exchange heuristic, which was originally developed for the closely related 2-partition problem. The evaluation is carried out on problem instances on graphs with up to 50 nodes for which the optimal partition values are known or upper bounds are available. The computational...... results show that among all instances with known optimal values the best partition values found by a randomized version of this heuristic lie well within 1% off the optimum....

  2. Comparatively evaluating the pharmacokinetic of fifteen constituents in normal and blood deficiency rats after oral administration of Xin-Sheng-Hua Granule by UPLC-MS/MS.

    Pang, Han-Qing; Tang, Yu-Ping; Cao, Yu-Jie; Tan, Ya-Jie; Jin, Yi; Shi, Xu-Qin; Huang, Sheng-Liang; Sun, Da-Zheng; Sun, Jin; Tang, Zhi-Shu; Duan, Jin-Ao

    2017-09-01

    Xin-Sheng-Hua Granule (XSHG), a famous traditional Chinese medicine prescription, are clinically applied for the treatment of postpartum disease through nourishing blood and promoting blood circulation. In this investigation, a multi-constituents (trigonelline, stachydrine hydrochloride, hydroxysafflor yellow A, chlorogenic acid, amygdalin, leonurine, liquiritin, ferulic acid, senkyunolide I, senkyunolide H, glycyrrhizic acid, senkyunolide A, ligustilide, butylidenephthalide and glycyrrhetinic acid) pharmacokinetic study of XSHG was conducted for the first time. These fifteen constituents in both normal and blood deficiency rat plasma were monitored by using the established and validated ultra-high-performance liquid chromatography coupled with a triple quadrupole electrospray tandem mass spectrometry (UPLC-TQ-MS/MS) method. The samples were prepared through removing protein from plasma with three volumes of methanol. Sufficient separation of target constituents and internal standards (chloramphenicol and clarithromycin) was obtained on a Thermo Scientific Hypersil GOLD column (100mm×3mm, 1.9μm) within a 20min gradient elution (0.1% formic acid aqueous - acetonitrile). Multiple reaction monitoring (MRM) mode was applied to monitor target analytes in both positive and negative electrospray ionization. For the fifteen selected target analytes, this method was fully validated with excellent linearity (r≥0.9925), satisfactory intra- and inter-day precisions (RSD≤11.87%), as well as good accuracies (RE, between -12.84 and 11.69). And the stabilities, matrix effects and extraction recoveries of the rat plasma samples were also within acceptable limits (RSD<15%). Compared to normal group, the pharmacokinetics of major active constituents (except liquiritin and glycyrrhetinic acid) had significant differences (P<0.05) in the model rats, indicated that several metabolite enzymes activities could be altered at disease condition. Copyright © 2017 Elsevier B.V. All

  3. Primordial dwarfism gene maintains Lin28 expression to safeguard embryonic stem cells from premature differentiation.

    Dai, Qian; Luan, Guangxin; Deng, Li; Lei, Tingjun; Kang, Han; Song, Xu; Zhang, Yujun; Xiao, Zhi-Xiong; Li, Qintong

    2014-05-08

    Primordial dwarfism (PD) is characterized by global growth failure, both during embryogenesis and postnatally. Loss-of-function germline mutations in La ribonucleoprotein domain family, member 7 (LAPR7) have recently been linked to PD. Paradoxically, LARP7 deficiency was previously assumed to be associated with increased cell growth and proliferation via activation of positive transcription elongation factor b (P-TEFb). Here, we show that Larp7 deficiency likely does not significantly increase P-TEFb activity. We further discover that Larp7 knockdown does not affect pluripotency but instead primes embryonic stem cells (ESCs) for differentiation via downregulation of Lin28, a positive regulator of organismal growth. Mechanistically, we show that Larp7 interacts with a poly(A) polymerase Star-PAP to maintain Lin28 mRNA stability. We propose that proper regulation of Lin28 and PTEFb is essential for embryonic cells to achieve a sufficient number of cell divisions prior to differentiation and ultimately to maintain proper organismal size. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  4. Dynamiques complexes et morphogenèse Introduction aux sciences non linéaires

    Misbah, Chaouqi

    2011-01-01

    Les sciences non linéaires ont pour objet l’ensemble des phénomènes dont l’analyse résiste au principe de superposition. Elles concernent en grande partie les systèmes dits « complexes » dont l’interaction et l’interdépendance entre les parties empêchent de prédire précisément l’évolution du système. Pour expliquer ces phénomènes, deux approches complémentaires ont été proposées : la théorie des bifurcations et la théorie des catastrophes. Mais la pleine compréhension et la modélisation de la non-linéarité restent chacune un défi pour les scientifiques du XXIe siècle. C’est dans la perspective d’accompagner tous ceux qui voudront le relever que ce livre a été conçu. Son objectif est d’exposer au lecteur le langage et le formalisme nécessaires à l’étude de la non-linéarité. Partant d’exemples simples, pour ensuite atteindre un niveau d’abstraction visant l’universalité, l’auteur explore les divers scénarios possibles de bifurcations et les catastr...

  5. Functional comparison of the nematode Hox gene lin-39 in C. elegans and P. pacificus reveals evolutionary conservation of protein function despite divergence of primary sequences.

    Grandien, K; Sommer, R J

    2001-08-15

    Hox transcription factors have been implicated in playing a central role in the evolution of animal morphology. Many studies indicate the evolutionary importance of regulatory changes in Hox genes, but little is known about the role of functional changes in Hox proteins. In the nematodes Pristionchus pacificus and Caenorhabditis elegans, developmental processes can be compared at the cellular, genetic, and molecular levels and differences in gene function can be identified. The Hox gene lin-39 is involved in the regulation of nematode vulva development. Comparison of known lin-39 mutations in P. pacificus and C. elegans revealed both conservation and changes of gene function. Here, we study evolutionary changes of lin-39 function using hybrid transgenes and site-directed mutagenesis in an in vivo assay using C. elegans lin-39 mutants. Our data show that despite the functional differences of LIN-39 between the two species, Ppa-LIN-39, when driven by Cel-lin-39 regulatory elements, can functionally replace Cel-lin-39. Furthermore, we show that the MAPK docking and phosphorylation motifs unique for Cel-LIN-39 are dispensable for Cel-lin-39 function. Therefore, the evolution of lin-39 function is driven by changes in regulatory elements rather than changes in the protein itself.

  6. Response to Niklasson's comment on Lin, et al. (2012) : "the relation between postural movement and bilateral motor integration".

    Lin, Chin-Kai; Kuo, Bor-Chen; Wu, Huey-Min

    2014-10-01

    In the study of Lin, Wu, Lin, Wu, Wu, Kuo, and Yeung (2012 ), the relationship between the validity of postural movement and bilateral motor integration in terms of sensory integration theory was examined. Postural movement is the ability to use the antigravity postures required for stabilization of the neck, trunk and upper extremities via muscle co-contractions in the neck and upper extremities, and balance. Niklasson's (2013 ) comment argued that postural movement should include primitive reflexes in terms of the general abilities approach. Niklasson (2013 ) focused on the efficacy of the treatment rather than the theoretical frameworks implied in the therapeutic activities. For that purpose Lin, et al. (2012 ) used sensory integration as the theoretical foundation, and the relationship between postural movement and bilateral motor integration was assessed via empirical data. The result of Lin, et al. (2012 ) was offered as a theoretical reference for therapeutic activities.

  7. On the reduction of generalized polylogarithms to Li_n and Li_2_,_2 and on the evaluation thereof

    Frellesvig, Hjalte; Tommasini, Damiano; Wever, Christopher

    2016-01-01

    We give expressions for all generalized polylogarithms up to weight four in terms of the functions log, Li_n, and Li_2_,_2, valid for arbitrary complex variables. Furthermore we provide algorithms for manipulation and numerical evaluation of Li_n and Li_2_,_2, and add codes in Mathematica and C++ implementing the results. With these results we calculate a number of previously unknown integrals, which we add in appendix C.

  8. Analysis of Sheng-Mai-San, a Ginseng-Containing Multiple Components Traditional Chinese Herbal Medicine Using Liquid Chromatography Tandem Mass Spectrometry and Physical Examination by Electron and Light Microscopies

    Yung-Yi Cheng

    2016-09-01

    Full Text Available Sheng-Mai-San is a multi-component traditional Chinese herbal preparation. Due to the fact granulated additives, such as starch, carboxymethyl cellulose, lactose and raw herbal powder may alter the content of the bioactive markers in the herbal products, a developed ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS method was used to measure the herbal biomarkers of ginsenoside Rb1, Rb2, Rc, Rd, Re, Rg1, Rh1, compound K, ophiopogonin D and schizandrin from the Sheng-Mai-San herbal formulation. Besides, scanning electron microscopy (SEM was used to observe the morphology of the herbal granular powders. Light microscopy with Congo red and iodine-KI reagent staining was used to identify the cellulose fiber and cornstarch added to pharmaceutical herbal products. The swelling power (SP, water solubility index (WSI, and crude fiber analysis were used to determine the contents of cellulose fiber and cornstarch in pharmaceutical herbal products. In this study, we developed a novel skill to assess the quantification of appended cornstarch in pharmaceutical herbal products using Aperio ImageScope software. Compared with the traditional cornstarch analysis, our analysis method is a rapid, simple and conversion process which could be applied to detect the percentage of added cornstarch in unknown powder products. The various range of the herbal content for the five pharmaceutical manufacturers varied by up to several hundreds-fold. The physical examination reveals that the morphology of the herbal pharmaceutical products is rough and irregular with sharp layers. This study provides a reference standard operating procedure guide for the quality control of the Chinese herbal pharmaceutical products of Sheng-Mai-San.

  9. Analysis of Sheng-Mai-San, a Ginseng-Containing Multiple Components Traditional Chinese Herbal Medicine Using Liquid Chromatography Tandem Mass Spectrometry and Physical Examination by Electron and Light Microscopies.

    Cheng, Yung-Yi; Tsai, Tung-Hu

    2016-09-01

    Sheng-Mai-San is a multi-component traditional Chinese herbal preparation. Due to the fact granulated additives, such as starch, carboxymethyl cellulose, lactose and raw herbal powder may alter the content of the bioactive markers in the herbal products, a developed ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method was used to measure the herbal biomarkers of ginsenoside Rb₁, Rb₂, Rc, Rd, Re, Rg₁, Rh₁, compound K, ophiopogonin D and schizandrin from the Sheng-Mai-San herbal formulation. Besides, scanning electron microscopy (SEM) was used to observe the morphology of the herbal granular powders. Light microscopy with Congo red and iodine-KI reagent staining was used to identify the cellulose fiber and cornstarch added to pharmaceutical herbal products. The swelling power (SP), water solubility index (WSI), and crude fiber analysis were used to determine the contents of cellulose fiber and cornstarch in pharmaceutical herbal products. In this study, we developed a novel skill to assess the quantification of appended cornstarch in pharmaceutical herbal products using Aperio ImageScope software. Compared with the traditional cornstarch analysis, our analysis method is a rapid, simple and conversion process which could be applied to detect the percentage of added cornstarch in unknown powder products. The various range of the herbal content for the five pharmaceutical manufacturers varied by up to several hundreds-fold. The physical examination reveals that the morphology of the herbal pharmaceutical products is rough and irregular with sharp layers. This study provides a reference standard operating procedure guide for the quality control of the Chinese herbal pharmaceutical products of Sheng-Mai-San.

  10. LIN Dataset

    Department of Homeland Security — This data is captured and helps to coordinate technical and scientific testing in the area of Trade Enforcement, WMD, Intellectual Property Rights, and Narcotics...

  11. Sheng-ji Hua-yu formula promotes diabetic wound healing of re-epithelization via Activin/Follistatin regulation.

    Kuai, Le; Zhang, Jing-Ting; Deng, Yu; Xu, Shun; Xu, Xun-Zhe; Wu, Min-Feng; Guo, Dong-Jie; Chen, Yu; Wu, Ren-Jie; Zhao, Xing-Qiang; Nian, Hua; Li, Bin; Li, Fu-Lun

    2018-01-29

    Sheng-ji Hua-yu(SJHY) formula is one of the most useful Traditional Chinese medicine (TCM) in the treatment of the delayed diabetic wound. However, elucidating the related molecular biological mechanism of how the SJHY Formula affects excessive inflammation in the process of re-epithelialization of diabetic wound healing is a task urgently needed to be fulfilled. The objectives of this study is to evaluate the effect of antagonisic expression of pro-/anti-inflammatory factors on transforming growth factor-β(TGF-β) superfamily (activin and follistatin) in the process of re-epithelialization of diabetic wound healing in vivo, and to characterize the involvement of the activin/follistatin protein expression regulation, phospho-Smad (pSmad2), and Nuclear factor kappa B p50 (NF-kB) p50 in the diabetic wound healing effects of SJHY formula. SJHY Formula was prepared by pharmaceutical preparation room of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine. Diabetic wound healing activity was evaluated by circular excision wound models. Wound healing activity was examined by macroscopic evaluation. Activin/follistatin expression regulation, protein expression of pSmad2 and NF-kB p50 in skin tissue of wounds were analyzed by Real Time PCR, Western blot, immunohistochemistry and hematoxylin and eosin (H&E) staining. Macroscopic evaluation analysis showed that wound healing of diabetic mice was delayed, and SJHY Formula accelerated wound healing time of diabetic mice. Real Time PCR analysis showed higher mRNA expression of activin/follistatin in diabetic delayed wound versus the wound in normal mice. Western Blot immunoassay analysis showed reduction of activin/follistatin proteins levels by SJHY Formula treatment 15 days after injury. Immunohistochemistry investigated the reduction of pSmad2 and NF-kB p50 nuclear staining in the epidermis of diabetic SJHY versus diabetic control mice on day 15 after wounding. H&E staining revealed that SJHY Formula

  12. LIN7A depletion disrupts cerebral cortex development, contributing to intellectual disability in 12q21-deletion syndrome.

    Ayumi Matsumoto

    Full Text Available Interstitial deletion of 12q21 has been reported in four cases, which share several common clinical features, including intellectual disability (ID, low-set ears, and minor cardiac abnormalities. Comparative genomic hybridization (CGH analysis using the Agilent Human Genome CGH 180K array was performed with the genomic DNA from a two-year-old Japanese boy with these symptoms, as well as hypoplasia of the corpus callosum. Consequently, a 14 Mb deletion at 12q21.2-q21.33 (nt. 77 203 574-91 264 613 bp, which includes 72 genes, was detected. Of these, we focused on LIN7A, which encodes a scaffold protein that is important for synaptic function, as a possible responsible gene for ID, and we analyzed its role in cerebral cortex development. Western blotting analyses revealed that Lin-7A is expressed on embryonic day (E 13.5, and gradually increases in the mouse brain during the embryonic stage. Biochemical fractionation resulted in the enrichment of Lin-7A in the presynaptic fraction. Suppression of Lin-7A expression by RNAi, using in utero electroporation on E14.5, delayed neuronal migration on postnatal day (P 2, and Lin-7A-deficient neurons remained in the lower zone of the cortical plate and the intermediate zone. In addition, when Lin-7A was silenced in cortical neurons in one hemisphere, axonal growth in the contralateral hemisphere was delayed; development of these neurons was disrupted such that one half did not extend into the contralateral hemisphere after leaving the corpus callosum. Taken together, LIN7A is a candidate gene responsible for 12q21-deletion syndrome, and abnormal neuronal migration and interhemispheric axon development may contribute to ID and corpus callosum hypoplasia, respectively.

  13. LIN28B polymorphisms are associated with central precocious puberty and early puberty in girls

    Sung Won Park

    2012-10-01

    Full Text Available &lt;B&gt;Purpose:&lt;/B&gt; Single-nucleotide polymorphism (SNP markers within &lt;i&gt;LIN28B&lt;/i&gt; have been reported to be related to the timing of pubertal growth. However, no study has investigated the frequency of genetic markers in girls with precocious puberty (PP or early puberty (EP. This study aimed to determine the frequency of putative genetic markers in girls with PP or EP. &lt;B&gt;Methods:&lt;/B&gt; Genomic DNAs were obtained from 77 and 109 girls that fulfilled the criteria for PP and EP, respectively. The controls in this study were 144 healthy volunteers between 20 and 30 years of age. The haplotypes were reconstructed using 11 SNPs of &lt;i&gt;LIN28B&lt;/i&gt;, and haplotype association analysis was performed. The haplotype frequencies were compared. Differences in the clinical and laboratory parameters were analyzed according to the haplotype dosage. &lt;B&gt;Results:&lt;/B&gt; Eleven SNPs in &lt;i&gt;LIN28B&lt;/i&gt; were all located in a block that was in linkage disequilibrium. The haplotype could be reconstructed using 2 representative SNPs, rs4946651 and rs369065. The AC haplotype was less frequently observed in the PP group than in the controls (0.069 vs. 0.144, &lt;I&gt;P&lt;/I&gt;=0.010. The trend that girls with non-AC haplotypes tended to have earlier puberty onset (&lt;I&gt;P&lt;/I&gt;=0.037 was illustrated even in the EP+PP patient group by Kaplan-Meier analysis. &lt;B&gt;Conclusion:&lt;/B&gt; The results of the present study showed that non-AC haplotypes of &lt;i&gt;LIN28B&lt;/i&gt;had a significant association with PP in girls.

  14. Lin28a Is Dormant, Functional, and Dispensable During Mouse Oocyte-to-Embryo Transition

    Flemr, Matyáš; Moravec, Martin; Libová, Veronika; Sedláček, Radislav; Svoboda, Petr

    2014-01-01

    Roč. 90, č. 6 (2014), s. 1-9 ISSN 0006-3363 R&D Projects: GA MŠk LH13084; GA MŠk(CZ) LM2011032; GA ČR(CZ) GBP305/12/G034 Institutional support: RVO:68378050 Keywords : early development * genome activation * guinea pigs * Let-7 * LIN28 * mice * microRNA * oocyte * rats * RNAi * rodents * transgenic/ knockout model * voles * zygote Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.318, year: 2014

  15. Lin28a uses distinct mechanisms of binding to RNA and affects miRNA levels positively and negatively.

    Nowak, Jakub Stanislaw; Hobor, Fruzsina; Downie Ruiz Velasco, Angela; Choudhury, Nila Roy; Heikel, Gregory; Kerr, Alastair; Ramos, Andres; Michlewski, Gracjan

    2017-03-01

    Lin28a inhibits the biogenesis of let-7 miRNAs by triggering the polyuridylation and degradation of their precursors by terminal uridylyltransferases TUT4/7 and 3'-5' exoribonuclease Dis3l2, respectively. Previously, we showed that Lin28a also controls the production of neuro-specific miRNA-9 via a polyuridylation-independent mechanism. Here we reveal that the sequences and structural characteristics of pre-let-7 and pre-miRNA-9 are eliciting two distinct modes of binding to Lin28a. We present evidence that Dis3l2 controls miRNA-9 production. Finally, we show that the constitutive expression of untagged Lin28a during neuronal differentiation in vitro positively and negatively affects numerous other miRNAs. Our findings shed light on the role of Lin28a in differentiating cells and on the ways in which one RNA-binding protein can perform multiple roles in the regulation of RNA processing. © 2017 Nowak et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

  16. Genome packaging in EL and Lin68, two giant phiKZ-like bacteriophages of P. aeruginosa

    Sokolova, O.S.; Shaburova, O.V.; Pechnikova, E.V.; Shaytan, A.K.; Krylov, S.V.; Kiselev, N.A.; Krylov, V.N.

    2014-01-01

    A unique feature of the Pseudomonas aeruginosa giant phage phiKZ is its way of genome packaging onto a spool-like protein structure, the inner body. Until recently, no similar structures have been detected in other phages. We have studied DNA packaging in P. aeruginosa phages EL and Lin68 using cryo-electron microscopy and revealed the presence of inner bodies. The shape and positioning of the inner body and the density of the DNA packaging in EL are different from those found in phiKZ and Lin68. This internal organization explains how the shorter EL genome is packed into a large EL capsid, which has the same external dimensions as the capsids of phiKZ and Lin68. The similarity in the structural organization in EL and other phiKZ-like phages indicates that EL is phylogenetically related to other phiKZ-like phages, and, despite the lack of detectable DNA homology, EL, phiKZ, and Lin68 descend from a common ancestor. - Highlights: • We performed a comparative structural study of giant P. aeruginosa phages: EL, Lin68 and phiKZ. • We revealed that the inner body is a common feature in giant phages. • The phage genome size correlates with the overall dimensions of the inner body

  17. Genome packaging in EL and Lin68, two giant phiKZ-like bacteriophages of P. aeruginosa

    Sokolova, O.S., E-mail: sokolova@mail.bio.msu.ru [M.V. Lomonosov Moscow State University, Moscow (Russian Federation); A.V. Shoubnikov Institute of Crystallography RAS, Moscow (Russian Federation); Shaburova, O.V. [I.I. Mechnikov Research Institute of Vaccines and Sera, RAMS, Moscow (Russian Federation); Pechnikova, E.V. [A.V. Shoubnikov Institute of Crystallography RAS, Moscow (Russian Federation); Shaytan, A.K. [M.V. Lomonosov Moscow State University, Moscow (Russian Federation); Krylov, S.V. [I.I. Mechnikov Research Institute of Vaccines and Sera, RAMS, Moscow (Russian Federation); Kiselev, N.A. [A.V. Shoubnikov Institute of Crystallography RAS, Moscow (Russian Federation); Krylov, V.N. [I.I. Mechnikov Research Institute of Vaccines and Sera, RAMS, Moscow (Russian Federation)

    2014-11-15

    A unique feature of the Pseudomonas aeruginosa giant phage phiKZ is its way of genome packaging onto a spool-like protein structure, the inner body. Until recently, no similar structures have been detected in other phages. We have studied DNA packaging in P. aeruginosa phages EL and Lin68 using cryo-electron microscopy and revealed the presence of inner bodies. The shape and positioning of the inner body and the density of the DNA packaging in EL are different from those found in phiKZ and Lin68. This internal organization explains how the shorter EL genome is packed into a large EL capsid, which has the same external dimensions as the capsids of phiKZ and Lin68. The similarity in the structural organization in EL and other phiKZ-like phages indicates that EL is phylogenetically related to other phiKZ-like phages, and, despite the lack of detectable DNA homology, EL, phiKZ, and Lin68 descend from a common ancestor. - Highlights: • We performed a comparative structural study of giant P. aeruginosa phages: EL, Lin68 and phiKZ. • We revealed that the inner body is a common feature in giant phages. • The phage genome size correlates with the overall dimensions of the inner body.

  18. LEDWIRE: A Versatile Networking Platform for Smart LED Lighting Applications Using LIN-Bus and WSNs

    Dimitrios D. Piromalis

    2016-05-01

    Full Text Available In this paper, the architecture of a versatile networking and control platform for Light-Emitting Diode (LED lighting applications is presented, based on embedded wireless and wired networking technologies. All the possible power and control signals distribution topologies of the lighting fixtures are examined with particular focus on dynamic lighting applications with design metrics as the cost, the required wiring installation expenses and maintenance complexity. The proposed platform is optimized for applications where the grouping of LED-based lighting fictures clusters is essential, as well as their synchronization. With such an approach, the distributed control and synchronization of LED lighting fixtures' clusters is performed through a versatile network that uses the single wire Local Interconnect Network (LIN bus. The proposed networking platform is presented in terms of its physical layer architecture, its data protocol configuration, and its functionality for smart control. As a proof of concept, the design of a LED lighting fixture together with a LIN-to-IEEE802.15.4/ZigBee data gateway is presented.

  19. Topografia ficcional: a construção do espaço nos manuscritos de Osman Lins

    Francisco José Gonçalves Lima Rocha

    2013-01-01

    Full Text Available In the construction of the narrative space of his final, unfinished novel, A cabeça levada em triunfo, Osman Lins operates both verbal, with notes planning, as iconically, through drawings. Will try to show that the author’s purpose is to clarify the topography of the work, because it establishes and harmonizes the technical functions - ie, like space, says Osman Lins, “frame” the character – and symbolic means, ie. how the space reflects, like all other elements of the work, the questioning of the head-body dichotomy.

  20. Traitement statistique des distorsions non-linéaires pour la restauration des enregistrements sonores.

    Picard , Guillaume

    2006-01-01

    L'objet de la thèse est l'étude, la modélisation et le traitement des distorsions non linéaires sonores, pour lesquelles les techniques actuelles s'avèrent impuissantes. L'approche retenue consiste à représenter, globalement, à la fois le signal audio à restaurer et le processus de distorsion, dans le cadre d'un modèle statistique. Cette approche présente un bon compromis entre une souhaitable généricité -possibilité de traiter à l'aide d'une méthode globale plusieurs types de distorsions- et...

  1. Reduction of EMC Emissions in Mixed Signal Integrated Circuits with Embedded LIN Driver

    P. Hartl

    2016-06-01

    Full Text Available This paper describes several methods for reduction of electromagnetic emissions (EME of mixed signal integrated circuits (IC. The focus is on the impact that a LIN bus communication block has on a complex IC which contains analog blocks, noisy digital block, micro-core (µC and several types of memories. It is used in an automotive environment, where EMC emission reduction is one of the key success factors. Several proposed methods for EME reduction are described and implemented on three test chips. These methods include current consumption reduction, internal on-chip decoupling, ground separation and different linear voltage regulator topologies. Measurement results of several fabricated test chips are shown and discussed.

  2. QUANTUM INSPIRED PARTICLE SWARM COMBINED WITH LIN-KERNIGHAN-HELSGAUN METHOD TO THE TRAVELING SALESMAN PROBLEM

    Bruno Avila Leal de Meirelles Herrera

    2015-12-01

    Full Text Available ABSTRACT The Traveling Salesman Problem (TSP is one of the most well-known and studied problems of Operations Research field, more specifically, in the Combinatorial Optimization field. As the TSP is a NP (Non-Deterministic Polynomial time-hard problem, there are several heuristic methods which have been proposed for the past decades in the attempt to solve it the best possible way. The aim of this work is to introduce and to evaluate the performance of some approaches for achieving optimal solution considering some symmetrical and asymmetrical TSP instances, which were taken from the Traveling Salesman Problem Library (TSPLIB. The analyzed approaches were divided into three methods: (i Lin-Kernighan-Helsgaun (LKH algorithm; (ii LKH with initial tour based on uniform distribution; and (iii an hybrid proposal combining Particle Swarm Optimization (PSO with quantum inspired behavior and LKH for local search procedure. The tested algorithms presented promising results in terms of computational cost and solution quality.

  3. José Lins do Rego: um guia brasileiro de Israel

    Glauber Pereira Quintão

    2010-03-01

    Full Text Available Este artigo procura analisar, de forma crítica, o livro de José Lins do Rego, Roteiro de Israel, 1955. Busca-­se destacar duas facetas suplementares: a de um olhar poético e a de uma preocupação ético-política lançados pelo escritor sobre a construção do novo Estado de Israel. Observa-­se também uma relação entre os signos da modernidade e das histórias arcaica judaicas. Para isso, usa-­se o conceito de palimpsesto, de Gerard Genette, e de flâneur, de Walter Benjamim.

  4. Lin28B promotes Müller glial cell de-differentiation and proliferation in the regenerative rat retinas

    Tao, Zui; Zhao, Chen; Jian, Qian; Gillies, Mark; Xu, Haiwei; Yin, Zheng Qin

    2016-01-01

    Retinal regeneration and repair are severely impeded in higher mammalian animals. Although Müller cells can be activated and show some characteristics of progenitor cells when injured or under pathological conditions, they quickly form gliosis scars. Unfortunately, the basic mechanisms that impede retinal regeneration remain unknown. We studied retinas from Royal College of Surgeon (RCS) rats and found that let-7 family molecules, let-7e and let-7i, were significantly overexpressed in Müller cells of degenerative retinas. It demonstrated that down-regulation of the RNA binding protein Lin28B was one of the key factors leading to the overexpression of let-7e and let-7i. Lin28B ectopic expression in the Müller cells suppressed overexpression of let-7e and let-7i, stimulated and mobilized Müller glia de-differentiation, proliferation, promoted neuronal commitment, and inhibited glial fate acquisition of de-differentiated Müller cells. ERG recordings revealed that the amplitudes of a-wave and b-wave were improved significantly after Lin28B was delivered into the subretinal space of RCS rats. In summary, down-regulation of Lin28B as well as up-regulation of let-7e and let-7i may be the main factors that impede Müller cell de-differentiation and proliferation in the retina of RCS rats. PMID:27384999

  5. [Analysis of acid rain characteristics of Lin'an Regional Background Station using long-term observation data].

    Li, Zheng-Quan; Ma, Hao; Mao, Yu-Ding; Feng, Tao

    2014-02-01

    Using long-term observation data of acid rain at Lin'an Regional Background Station (Lin'an RBS), this paper studied the interannual and monthly variations of acid rain, the reasons for the variations, and the relationships between acid rain and meteorological factors. The results showed that interannual variation of acid rain at Lin'an RBS had a general increasing trend in which there were two obvious intensifying processes and two distinct weakening processes, during the period ranging from 1985 to 2012. In last two decades, the monthly variation of acid rain at Lin'an RBS indicated that rain acidity and frequency of severe acid rain were increasing but the frequency of weak acid rain was decreasing when moving towards bilateral side months of July. Acid rain occurrence was affected by rainfall intensity, wind speed and wind direction. High frequency of severe acid rain and low frequency of weak acid rain were on days with drizzle, but high frequency of weak acid rain and low frequency of severe acid rain occurred on rainstorm days. With wind speed upgrading, the frequency of acid rain and the proportion of severe acid rain were declining, the pH value of precipitation was reducing too. Another character is that daily dominant wind direction of weak acid rain majorly converged in S-W section ,however that of severe acid rain was more likely distributed in N-E section. The monthly variation of acid rain at Lin'an RBS was mainly attributed to precipitation variation, the increasing and decreasing of monthly incoming wind from SSE-WSW and NWN-ENE sections of wind direction. The interannual variation of acid rain could be due to the effects of energy consumption raising and significant green policies conducted in Zhejiang, Jiangsu and Shanghai.

  6. LIN28 expression in malignant germ cell tumors down-regulates let-7 and increases oncogene levels

    Murray, Matthew J.; Saini, Harpreet K.; Siegler, Charlotte A.; Hanning, Jennifer E.; Barker, Emily M.; van Dongen, Stijn; Ward, Dawn M.; Raby, Katie L.; Groves, Ian J.; Scarpini, Cinzia G.; Pett, Mark R.; Thornton, Claire M.; Enright, Anton J.; Nicholson, James C.; Coleman, Nicholas

    2013-01-01

    Despite their clinico-pathologic heterogeneity, malignant germ-cell-tumors (GCTs) share molecular abnormalities that are likely to be functionally important. In this study, we investigated the potential significance of down-regulation of the let-7 family of tumor-suppressor microRNAs in malignant-GCTs. Microarray results from pediatric and adult samples (n=45) showed that LIN28, the negative-regulator of let-7 biogenesis, was abundant in malignant-GCTs, regardless of patient age, tumor site or histologic subtype. Indeed, a strong negative-correlation existed between LIN28 and let-7 levels in specimens with matched datasets. Low let-7 levels were biologically significant, since the sequence complementary to the 2-7nt common let-7 seed ‘GAGGUA’ was enriched in the 3′untranslated regions of mRNAs up-regulated in pediatric and adult malignant-GCTs, compared with normal gonads (a mixture of germ cells and somatic cells). We identified 27 mRNA targets of let-7 that were up-regulated in malignant-GCT cells, confirming significant negative-correlations with let-7 levels. Among 16 mRNAs examined in a largely independent set of specimens by qRT-PCR, we defined negative-associations with let-7e levels for six oncogenes, including MYCN, AURKB, CCNF, RRM2, MKI67 and C12orf5 (when including normal control tissues). Importantly, LIN28 depletion in malignant-GCT cells restored let-7 levels and repressed all of these oncogenic let-7 mRNA targets, with LIN28 levels correlating with cell proliferation and MYCN levels. Conversely, ectopic expression of let-7e was sufficient to reduce proliferation and down-regulate MYCN, AURKB and LIN28, the latter via a double-negative feedback loop. We concluded that the LIN28/let-7 pathway has a critical pathobiological role in malignant-GCTs and therefore offers a promising target for therapeutic intervention. PMID:23774216

  7. Analysis of a lin-42/period Null Allele Implicates All Three Isoforms in Regulation of Caenorhabditis elegans Molting and Developmental Timing

    Theresa L. B. Edelman

    2016-12-01

    Full Text Available The Caenorhabditis elegans heterochronic gene pathway regulates the relative timing of events during postembryonic development. lin-42, the worm homolog of the circadian clock gene, period, is a critical element of this pathway. lin-42 function has been defined by a set of hypomorphic alleles that cause precocious phenotypes, in which later developmental events, such as the terminal differentiation of hypodermal cells, occur too early. A subset of alleles also reveals a significant role for lin-42 in molting; larval stages are lengthened and ecdysis often fails in these mutant animals. lin-42 is a complex locus, encoding overlapping and nonoverlapping isoforms. Although existing alleles that affect subsets of isoforms have illuminated important and distinct roles for this gene in developmental timing, molting, and the decision to enter the alternative dauer state, it is essential to have a null allele to understand all of the roles of lin-42 and its individual isoforms. To remedy this problem and discover the null phenotype, we engineered an allele that deletes the entire lin-42 protein-coding region. lin-42 null mutants are homozygously viable, but have more severe phenotypes than observed in previously characterized hypomorphic alleles. We also provide additional evidence for this conclusion by using the null allele as a base for reintroducing different isoforms, showing that each isoform can provide heterochronic and molting pathway activities. Transcript levels of the nonoverlapping isoforms appear to be under coordinate temporal regulation, despite being driven by independent promoters. The lin-42 null allele will continue to be an important tool for dissecting the functions of lin-42 in molting and developmental timing.

  8. Overexpression of Lin28b in Neural Stem Cells is Insufficient for Brain Tumor Formation, but Induces Pathological Lobulation of the Developing Cerebellum.

    Wefers, Annika K; Lindner, Sven; Schulte, Johannes H; Schüller, Ulrich

    2017-02-01

    LIN28B is a homologue of the RNA-binding protein LIN28A and regulates gene expression during development and carcinogenesis. It is strongly upregulated in a variety of brain tumors, such as medulloblastoma, embryonal tumor with multilayered rosettes (ETMR), atypical teratoid/rhabdoid tumor (AT/RT), or glioblastoma, but the effect of an in vivo overexpression of LIN28B on the developing central nervous system is unknown. We generated transgenic mice that either overexpressed Lin28b in Math1-positive cerebellar granule neuron precursors or in a broad range of Nestin-positive neural precursors. Sections of the cerebellar vermis from adult Math1-Cre::lsl-Lin28b mice had an additional subfissure in lobule IV. Vermes from p0 and p7 Nestin-Cre::lsl-Lin28b mice appeared normal, but we found a pronounced vermal hypersublobulation at p15 and p21 in these mice. Also, the external granule cell layer (EGL) was thicker at p15 than in controls, contained more proliferating cells, and persisted up to p21. Consistently, some Pax6- and NeuN-positive cells were present in the EGL of Nestin-Cre::lsl-Lin28b mice even at p21, and we detected more NeuN-positive granule neuron precursors in the molecular layer (ML) as compared to control. Finally, we found some residual Pax2-positive precursors of inhibitory interneurons in the ML of Nestin-Cre::lsl-Lin28b mice at p21, which have already disappeared in controls. We conclude that while overexpression of LIN28B in Nestin-positive cells does not lead to tumor formation, it results in a protracted development of granule cells and inhibitory interneurons and leads to a hypersublobulation of the cerebellar vermis.

  9. In vitro and in vivo antimicrobial activities of seeds of Caesalpinia bonduc (Lin.) Roxb.

    Arif, Tasleem; Mandal, T K; Kumar, Naresh; Bhosale, J D; Hole, Archana; Sharma, G L; Padhi, M M; Lavekar, G S; Dabur, Rajesh

    2009-05-04

    Caesalpinia bonduc (Lin.) Roxb. is a known drug in Ayurveda to treat various diseases specifically tumors, cysts and cystic fibrosis (CF). The aim of this study was to assess in vitro as well as in vivo antimicrobial activity of Caesalpinia bonduc seeds. The in vitro antimicrobial activities of seed coat and seed kernel extracts were investigated by microbroth dilution assay. In vivo activities of hydro-alcoholic extracts were investigated in rat models of chronic Pseudomonas aeruginosa pneumonia mimicking that in patients with cystic fibrosis. Various extracts of plant seeds exhibited in vitro antimicrobial activities in a range of 22-350 microg/ml. The extracts also showed activity against methicillin resistant (MR) Staphylococcus aureus and ampicillin resistant (AR) Pseudomonas aeruginosa as in the sensitive strains. In rat model of chronic Pseudomonas aeruginosa pneumonia, hydro-alcoholic extracts of Caesalpinia bonduc seed kernel (CBSK) and Caesalpinia bonduc seed coat (CBSC) were injected subcutaneously in the test groups of animals. The control groups were treated with cortisone and saline. Two weeks after challenge with Pseudomonas aeruginosa, the CBSK treated animals showed a significant bacterial clearance from the lungs (PCaesalpinia bonduc may have the potential to be promising natural medicine, with other forms of treatments, for CF patients with chronic Pseudomonas aeruginosa lung infections.

  10. Solving quantum optimal control problems using Clebsch variables and Lin constraints

    Delgado-Téllez, M.; Ibort, A.; Rodríguez de la Peña, T.

    2018-01-01

    Clebsch variables (and Lin constraints) are applied to the study of a class of optimal control problems for affine-controlled quantum systems. The optimal control problem will be modelled with controls defined on an auxiliary space where the dynamical group of the system acts freely. The reciprocity between both theories: the classical theory defined by the objective functional and the quantum system, is established by using a suitable version of Lagrange’s multipliers theorem and a geometrical interpretation of the constraints of the system as defining a subspace of horizontal curves in an associated bundle. It is shown how the solutions of the variational problem defined by the objective functional determine solutions of the quantum problem. Then a new way of obtaining explicit solutions for a family of optimal control problems for affine-controlled quantum systems (finite or infinite dimensional) is obtained. One of its main advantages, is the the use of Clebsch variables allows to compute such solutions from solutions of invariant problems that can often be computed explicitly. This procedure can be presented as an algorithm that can be applied to a large class of systems. Finally, some simple examples, spin control, a simple quantum Hamiltonian with an ‘Elroy beanie’ type classical model and a controlled one-dimensional quantum harmonic oscillator, illustrating the main features of the theory, will be discussed.

  11. Long noncoding RNA TUG1 facilitates osteogenic differentiation of periodontal ligament stem cells via interacting with Lin28A.

    He, Qin; Yang, Shuangyan; Gu, Xiuge; Li, Mengying; Wang, Chunling; Wei, Fulan

    2018-04-19

    Periodontal ligament stem cells (PDLSCs) are mesenchymal stem cells derived from dental tissues with multidirectional differentiation potential and excellent self-renewing ability. Recently, long noncoding RNAs (lncRNAs) have been shown to play important roles in MSC osteogenic differentiation. In this study, we found that taurine upregulated gene 1 (TUG1), an evolutionarily conserved and widely present lncRNA was significantly upregulated in osteogenically induced PDLSCs compared to their undifferentiated counterparts. Further investigation demonstrated that the expression of TUG1 was positively correlated with the osteogenic differentiation of PDLSCs following the induction, as evidenced by the increase in cellular alkaline phosphatase (ALP) level, formation of calcium nodules, and the upregulation of several osteogenic-related gene markers such as ALP, osteocalcin (OCN), and runt-related transcription factor 2 (Runx2). Conversely, TUG1 knockdown was demonstrated to inhibit the potential of PDLSCs for osteogenic differentiation. Using bioinformatics analysis, we identified lin-28 homolog A (Lin28A) as a potential target of TUG1 during osteogenic differentiation of PDLSCs. Lin28A was found to be significantly downregulated in TUG1-repressed PDLSCs and contained multiple binding sites for lncRNA TUG1. Moreover, suppression of Lin28A was shown to be able to inhibit osteogenic differentiation and decreased the expression of several osteogenic genes. Taken together, these results could help researchers better understand the mechanism that governs the osteogenic differentiation of PDLSCs, and also serve as a stepping stone for the development of novel therapeutic strategies that can be used to regenerate dental tissues.

  12. A role for the malignant brain tumour (MBT domain protein LIN-61 in DNA double-strand break repair by homologous recombination.

    Nicholas M Johnson

    Full Text Available Malignant brain tumour (MBT domain proteins are transcriptional repressors that function within Polycomb complexes. Some MBT genes are tumour suppressors, but how they prevent tumourigenesis is unknown. The Caenorhabditis elegans MBT protein LIN-61 is a member of the synMuvB chromatin-remodelling proteins that control vulval development. Here we report a new role for LIN-61: it protects the genome by promoting homologous recombination (HR for the repair of DNA double-strand breaks (DSBs. lin-61 mutants manifest numerous problems associated with defective HR in germ and somatic cells but remain proficient in meiotic recombination. They are hypersensitive to ionizing radiation and interstrand crosslinks but not UV light. Using a novel reporter system that monitors repair of a defined DSB in C. elegans somatic cells, we show that LIN-61 contributes to HR. The involvement of this MBT protein in HR raises the possibility that MBT-deficient tumours may also have defective DSB repair.

  13. DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans.

    Reddien, Peter W; Andersen, Erik C; Huang, Michael C; Horvitz, H Robert

    2007-04-01

    The genes egl-1, ced-9, ced-4, and ced-3 play major roles in programmed cell death in Caenorhabditis elegans. To identify genes that have more subtle activities, we sought mutations that confer strong cell-death defects in a genetically sensitized mutant background. Specifically, we screened for mutations that enhance the cell-death defects caused by a partial loss-of-function allele of the ced-3 caspase gene. We identified mutations in two genes not previously known to affect cell death, dpl-1 and mcd-1 (modifier of cell death). dpl-1 encodes the C. elegans homolog of DP, the human E2F-heterodimerization partner. By testing genes known to interact with dpl-1, we identified roles in cell death for four additional genes: efl-1 E2F, lin-35 Rb, lin-37 Mip40, and lin-52 dLin52. mcd-1 encodes a novel protein that contains one zinc finger and that is synthetically required with lin-35 Rb for animal viability. dpl-1 and mcd-1 act with efl-1 E2F and lin-35 Rb to promote programmed cell death and do so by regulating the killing process rather than by affecting the decision between survival and death. We propose that the DPL-1 DP, MCD-1 zinc finger, EFL-1 E2F, LIN-35 Rb, LIN-37 Mip40, and LIN-52 dLin52 proteins act together in transcriptional regulation to promote programmed cell death.

  14. Relevance of the Lin's and Host hydropedological models to predict grape yield and wine quality

    E. A. C. Costantini

    2009-09-01

    Full Text Available The adoption of precision agriculture in viticulture could be greatly enhanced by the diffusion of straightforward and easy to be applied hydropedological models, able to predict the spatial variability of available soil water. The Lin's and Host hydropedological models were applied to standard soil series descriptions and hillslope position, to predict the distribution of hydrological functional units in two vineyard and their relevance for grape yield and wine quality. A three-years trial was carried out in Chianti (Central Italy on Sangiovese. The soils of the vineyards differentiated in structure, porosity and related hydropedological characteristics, as well as in salinity. Soil spatial variability was deeply affected by earth movement carried out before vine plantation. Six plots were selected in the different hydrological functional units of the two vineyards, that is, at summit, backslope and footslope morphological positions, to monitor soil hydrology, grape production and wine quality. Plot selection was based upon a cluster analysis of local slope, topographic wetness index (TWI, and cumulative moisture up to the root limiting layer, appreciated by means of a detailed combined geophysical survey. Water content, redox processes and temperature were monitored, as well as yield, phenological phases, and chemical analysis of grapes. The isotopic ratio δ13C was measured in the wine ethanol upon harvesting to evaluate the degree of stress suffered by vines. The grapes in each plot were collected for wine making in small barrels. The wines obtained were analysed and submitted to a blind organoleptic testing.

    The results demonstrated that the combined application of the two hydropedological models can be used for the prevision of the moisture status of soils cultivated with grape during summertime in Mediterranean climate. As correctly foreseen by the models, the amount of mean daily transpirable soil water (TSW during

  15. Optical and electrical properties of zinc oxide thin films with low resistivity via Li-N dual-acceptor doping

    Zhang Daoli, E-mail: zhang_daoli@mail.hust.edu.cn [Department of Electronic Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Wuhan National Laboratory for Optoelectronics, 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Zhang Jianbing [Department of Electronic Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Wuhan National Laboratory for Optoelectronics, 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Guo Zhe [Department of Electronic Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Miao Xiangshui [Department of Electronic Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Wuhan National Laboratory for Optoelectronics, 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China)

    2011-05-19

    Highlights: > Zinc oxide films have been deposited on glass substrates by Li-N dual-acceptor doping method via a modified SILAR method. > The resistivity of ZnO film was found to be 1.04 {Omega} cm with a Hall mobility of 0.749 cm{sup 2} V{sup -1} s{sup -1}, carrier concentration of 8.02 x 1018 cm{sup -3}, and transmittance of about 80% in visible range showing good crystallinity with prior c-axis orientation. > A shallow acceptor level of 91 meV is identified from free-to-neutral-acceptor transitions. > Another deep level of 255 meV was ascribed to Li{sub Zn}-Li{sub i} complex. - Abstract: Zinc oxide thin films with low resistivity have been deposited on glass substrates by Li-N dual-acceptor doping method via a modified successive ionic layer adsorption and reaction process. The thin films were systematically characterized via scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray diffraction, ultraviolet-visible spectrophotometry and fluorescence spectrophotometry. The resistivity of zinc oxide film was found to be 1.04 {Omega} cm with a Hall mobility of 0.749 cm{sup 2} V{sup -1} s{sup -1} and carrier concentration of 8.02 x 10{sup 18} cm{sup -3}. The Li-N dual-acceptor doped zinc oxide films showed good crystallinity with prior c-axis orientation, and high transmittance of about 80% in visible range. Moreover, the effects of Li doping level and other parameters on crystallinity, electrical and ultraviolet emission of zinc oxide films were investigated.

  16. Lin28a is a putative factor in regulating cancer stem cell-like properties in side population cells of oral squamous cell carcinoma

    Hayashi, S.; Tanaka, J.; Okada, S.; Isobe, T.; Yamamoto, G.; Yasuhara, R.; Irie, T.; Akiyama, C.; Kohno, Y.; Tachikawa, T.; Mishima, K., E-mail: mishima-k@dent.showa-u.ac.jp

    2013-05-01

    Cancer stem cells (CSCs) are among the target cells of cancer therapy because they are uniquely involved in both cancer progression and sensitivity to chemotherapeutic agents. We identified side population (SP) cells, which are known to be an enriched population of CSC, in five oral squamous cell carcinoma (OSCC) cells (SCC9, SCC25, TOSCC7, TOSCC17, and TOSCC23). The percentages of SP cells ranged from 0% to 3.3%, with TOSCC23 cells showing the highest percentages of SP cells (3.3% of the total cell population). The SP cells isolated from TOSCC23 cells also showed greater cell proliferation and invasion compared to non-SP (MP) cells. Therefore, our initial findings suggested that SP cells were enriched for CSC-like cells. Furthermore, DNA microarray analysis revealed that the expression of cell proliferation-related and anti-apoptotic genes was greater in SP cells compared to MP cells. We focused on Lin28a, which showed the highest expression (approximately 22-fold) among the upregulated genes. The overexpression of Lin28a in TOSCC23 cells increased their proliferation, colony formation, and invasion. These findings suggest that Lin28a is an appropriate CSC target molecule for OSCC treatment - Highlights: ► Lin28a is a SP cell-specific factor in oral squamous cell carcinoma (OSCC) cells. ► SP cells in OSCC cells show cancer stem cell-like properties. ► Lin28a regulates OSCC proliferative and invasive activities.

  17. Lin28a is a putative factor in regulating cancer stem cell-like properties in side population cells of oral squamous cell carcinoma

    Hayashi, S.; Tanaka, J.; Okada, S.; Isobe, T.; Yamamoto, G.; Yasuhara, R.; Irie, T.; Akiyama, C.; Kohno, Y.; Tachikawa, T.; Mishima, K.

    2013-01-01

    Cancer stem cells (CSCs) are among the target cells of cancer therapy because they are uniquely involved in both cancer progression and sensitivity to chemotherapeutic agents. We identified side population (SP) cells, which are known to be an enriched population of CSC, in five oral squamous cell carcinoma (OSCC) cells (SCC9, SCC25, TOSCC7, TOSCC17, and TOSCC23). The percentages of SP cells ranged from 0% to 3.3%, with TOSCC23 cells showing the highest percentages of SP cells (3.3% of the total cell population). The SP cells isolated from TOSCC23 cells also showed greater cell proliferation and invasion compared to non-SP (MP) cells. Therefore, our initial findings suggested that SP cells were enriched for CSC-like cells. Furthermore, DNA microarray analysis revealed that the expression of cell proliferation-related and anti-apoptotic genes was greater in SP cells compared to MP cells. We focused on Lin28a, which showed the highest expression (approximately 22-fold) among the upregulated genes. The overexpression of Lin28a in TOSCC23 cells increased their proliferation, colony formation, and invasion. These findings suggest that Lin28a is an appropriate CSC target molecule for OSCC treatment - Highlights: ► Lin28a is a SP cell-specific factor in oral squamous cell carcinoma (OSCC) cells. ► SP cells in OSCC cells show cancer stem cell-like properties. ► Lin28a regulates OSCC proliferative and invasive activities

  18. Opposing Post-transcriptional Control of InR by FMRP and LIN-28 Adjusts Stem Cell-Based Tissue Growth

    Arthur Luhur

    2017-12-01

    Full Text Available Summary: Although the intrinsic mechanisms that control whether stem cells divide symmetrically or asymmetrically underlie tissue growth and homeostasis, they remain poorly defined. We report that the RNA-binding protein fragile X mental retardation protein (FMRP limits the symmetric division, and resulting expansion, of the stem cell population during adaptive intestinal growth in Drosophila. The elevated insulin sensitivity that FMRP-deficient progenitor cells display contributes to their accelerated expansion, which is suppressed by the depletion of insulin-signaling components. This FMRP activity is mediated solely via a second conserved RNA-binding protein, LIN-28, known to boost insulin signaling in stem cells. Via LIN-28, FMRP controls progenitor cell behavior by post-transcriptionally repressing the level of insulin receptor (InR. This study identifies the stem cell-based mechanism by which FMRP controls tissue adaptation, and it raises the possibility that defective adaptive growth underlies the accelerated growth, gastrointestinal, and other symptoms that affect fragile X syndrome patients. : Luhur et al. report that FMRP acts via LIN-28 in progenitor cells to dampen the adaptive expansion of intestinal tissue in the fruit fly, raising the possibility that defective LIN28-mediated adaptive growth underlies some of the symptoms that affect fragile X syndrome patients. Keywords: FMRP, fmr1, LIN-28, insulin receptor, IIS, adaptive growth, tissue resizing, intestinal stem cell, insulin sensitivity

  19. Comparability of estimating energy rebound effect should be based on uniform mechanism and benchmark: A reply to Du and Lin

    Li, Chengyu; Shao, Shuai; Yang, Lili; Yu, Mingliang

    2016-01-01

    Du and Lin (2015) argued that the estimation model of the economy-wide energy rebound effect proposed by Shao et al. (2014) should be revised and provided an alternative approach, which they considered to be more consistent with the definition of the rebound effect. However, in this comment, we do not find a valid correction or modification to our original model, because their criticism logic does not originate from the corresponding mechanism in Shao et al. (2014), and their estimation formula has a different benchmark with ours. Moreover, their data samples were also different from ours, generating the incomparable results, and there are some irrational results in the comment. Even based on different estimation formulas in the two studies and using the same estimation method and data sample, the comparison results show that the problem of the estimation formula in our previous study which they claimed does not really exist. We argue that this comment is not consistent with the principle of the rebound effect. Actually, their work can be only regarded as proposing an alternative approach for the estimate of the rebound effect. Therefore, their argument is not enough to overturn our previous study. - Highlights: • A reply to Du and Lin (2015), who questioned our previous study, is provided. • Their criticism logic does not originate from our corresponding mechanism. • Their estimation formula has a different benchmark with ours. • Different data samples in the two papers make their results incomparable. • Their argument is not enough to overturn our previous study.

  20. Nanos promotes epigenetic reprograming of the germline by down-regulation of the THAP transcription factor LIN-15B.

    Lee, Chih-Yung Sean; Lu, Tu; Seydoux, Geraldine

    2017-11-07

    Nanos RNA-binding proteins are required for germline development in metazoans, but the underlying mechanisms remain poorly understood. We have profiled the transcriptome of primordial germ cells (PGCs) lacking the nanos homologs nos-1 and nos-2 in C. elegans. nos-1nos-2 PGCs fail to silence hundreds of transcripts normally expressed in oocytes. We find that this misregulation is due to both delayed turnover of maternal transcripts and inappropriate transcriptional activation. The latter appears to be an indirect consequence of delayed turnover of the maternally-inherited transcription factor LIN-15B, a synMuvB class transcription factor known to antagonize PRC2 activity. PRC2 is required for chromatin reprogramming in the germline, and the transcriptome of PGCs lacking PRC2 resembles that of nos-1nos-2 PGCs. Loss of maternal LIN-15B restores fertility to nos-1nos-2 mutants. These findings suggest that Nanos promotes germ cell fate by downregulating maternal RNAs and proteins that would otherwise interfere with PRC2-dependent reprogramming of PGC chromatin.

  1. Weak activity of haloalkane dehalogenase LinB with 1,2,3-trichloropropane revealed by X-Ray crystallography and microcalorimetry.

    Monincová, Marta; Prokop, Zbynek; Vévodová, Jitka; Nagata, Yuji; Damborsky, Jirí

    2007-03-01

    1,2,3-Trichloropropane (TCP) is a highly toxic and recalcitrant compound. Haloalkane dehalogenases are bacterial enzymes that catalyze the cleavage of a carbon-halogen bond in a wide range of organic halogenated compounds. Haloalkane dehalogenase LinB from Sphingobium japonicum UT26 has, for a long time, been considered inactive with TCP, since the reaction cannot be easily detected by conventional analytical methods. Here we demonstrate detection of the weak activity (k(cat) = 0.005 s(-1)) of LinB with TCP using X-ray crystallography and microcalorimetry. This observation makes LinB a useful starting material for the development of a new biocatalyst toward TCP by protein engineering. Microcalorimetry is proposed to be a universal method for the detection of weak enzymatic activities. Detection of these activities is becoming increasingly important for engineering novel biocatalysts using the scaffolds of proteins with promiscuous activities.

  2. Weak Activity of Haloalkane Dehalogenase LinB with 1,2,3-Trichloropropane Revealed by X-Ray Crystallography and Microcalorimetry▿

    Monincová, Marta; Prokop, Zbyněk; Vévodová, Jitka; Nagata, Yuji; Damborský, Jiří

    2007-01-01

    1,2,3-Trichloropropane (TCP) is a highly toxic and recalcitrant compound. Haloalkane dehalogenases are bacterial enzymes that catalyze the cleavage of a carbon-halogen bond in a wide range of organic halogenated compounds. Haloalkane dehalogenase LinB from Sphingobium japonicum UT26 has, for a long time, been considered inactive with TCP, since the reaction cannot be easily detected by conventional analytical methods. Here we demonstrate detection of the weak activity (kcat = 0.005 s−1) of LinB with TCP using X-ray crystallography and microcalorimetry. This observation makes LinB a useful starting material for the development of a new biocatalyst toward TCP by protein engineering. Microcalorimetry is proposed to be a universal method for the detection of weak enzymatic activities. Detection of these activities is becoming increasingly important for engineering novel biocatalysts using the scaffolds of proteins with promiscuous activities. PMID:17259360

  3. [Heavy metal pollution characteristics and ecological risk analysis for soil in Phyllostachys praecox stands of Lin'an].

    Fang, Xiao-bo; Shi, Han; Liao, Xin-feng; Lou, Zhong; Zhou, Lyu-yan; Yu, Hai-xia; Yao, Lin; Sun, Li-ping

    2015-06-01

    An investigation was carried out in an attempt to reveal the characteristics of heavy metals contamination in the soils of Phyllostachys praecox forest in Lin' an. Based on the concentrations of Hg, As, Cu, Pb, Zn, Cd, Cr, Ni, Co and Mn in 160 topsoil samples, the pollution status and ecological risks of heavy metals in the soils were assessed by single factor pollution index, Nemerow integrated pollution index and Hankanson potential ecological risk index. The spatial variability of heavy metal concentrations in the soils closely related to the distribution of traffic, industrial and livestock pollution sources. The average concentrations of Hg, As, Cu, Pb, Zn, Cd, Cr, Ni, Co and Mn in the soils were 0.16, 7.41, 34.36, 87.98, 103.98, 0.26, 59.12, 29.56, 11.44 and 350.26 mg · kg(-1), respectively. Pb, Cd, Zn and Cu concentrations were as 2.89, 1.70, 1.12 and 1.12 times as the background values of soil in Zhejiang Province, respectively. But their concentrations were all lower than the threshold values of the National Environmental Quality Standard for Soil (GB 15618-1995). The average single factor pollution index revealed that the level of heavy metal pollution in the soils was in order of Pb>Cd>Cu= Zn>Hg>As>Ni>Co>Cr>Mn. Pb pollution was of moderate level while Cd, Cu and Zn pollutions were slight. There was no soil pollution caused by the other heavy metals. However, the Nemerow integrated pollution index showed that all the 160 soil samples were contaminated by heavy metals to a certain extent. Among total 160 soil samples, slight pollution level, moderate pollution level and heavy pollution level accounted for 55.6%, 29.4% and 15.0%, respectively. The average single factor potential ecological risk index (Er(i)) implied that the potential ecological risk related to Cd reached moderate level, while the others were of slight level. Furthermore, Cd and Hg showed higher potential ecological risk indices which reached up to 256.82 and 187.33 respectively

  4. A MULHER NEGRA E AS RELAÇÕES DE GÊNERO EM MENINO DE ENGENHO DE JOSÉ LINS DO REGO THE BLACK WOMAN AND GENDER RELATIONS IN MENINO DE ENGENHO BY JOSÉ LINS DO REGO

    Zélia Monteiro Bora ; Marina Rodrigues de Oliveira

    2011-02-01

    Full Text Available Os romances do ciclo da cana-de-açúcar, do escritor paraibano José Lins do Rego (1901-1957 e a sua relação com a sociedade e a cultura destacam-se enquanto abordagens ficcionais, através das quais o escritor buscou representar aspectos relevantes para o entendimento das relações de gênero no Nordeste, no começo do século vinte. Tal representação, indiscutivelmente, reflete a perspectiva de um narrador profundamente marcado pelo lugar privilegiado de onde narra e de sua condição existencial, como o neto de um senhor de engenho. Diante desses aspectos, propomo- nos a analisar brevemente as implicações dessa perspectiva sobre a construção simbólica da personagem negra representada no romance. Para tanto, serão utilizados como referenciais críticos, além do citado romance, os estudos de Zagury (1982, Albuquerque Jr. (1999, Azevedo (1996, 2007, Freyre (2006 Chaguri (2009, Schwarz (2008 e Raboni (2010.The so called sugar cane cycle novels by the Parahyban writer Jose Lins do Rego (1901-197 and its relationship with society and culture constitute themselves as fictional approaches through which the writer sought to represent aspects to the understanding of gender relations in the Northeast of Brazil in the early twentieth century. Such representation, undoubtedly reflects the perspective of a narrator deeply marked by the privileged place from which he narrates and his existential condition, as the son of a plantation owner. Given these aspects, we propose to examine briefly the implications of his perspective on the symbolic construction of the black woman characteres represented in the novel. The following

  5. Search for the signature of a halo structure in the p(6He,6Li)n reaction

    Cortina-Gil, M.D.; Roussel-Chomaz, P.; Mittig, W.; Casandjian, J.M.; Chartier, M.; Alamanos, N.; Auger, F.; Fekou-Youmbi, V.; Blumenfeld, Y.; and others.

    1995-01-01

    The elastic scattering p( 6 He, 6 He)p and charge exchange reaction p( 6 He, 6 Li)n have been measured in reverse kinematics with a secondary 6 He beam. The angular distributions for these reactions were obtained. In the case of the charge exchange reaction, the ratio of the cross section for the Gamow-Teller transition to the ground state, and for the Fermi transition to the isobaric analog state is a measure of the relative strength of the two components of the exchange interaction. This ratio is found compatible with existing systematics for stable T=1 nuclei, and no clear signature of a halo structure was found in the present data. (author)

  6. Regio- and Enantioselective Sequential Dehalogenation of rac-1,3-Dibromobutane by Haloalkane Dehalogenase LinB.

    Gross, Johannes; Prokop, Zbyněk; Janssen, Dick; Faber, Kurt; Hall, Mélanie

    2016-08-03

    The hydrolytic dehalogenation of rac-1,3-dibromobutane catalyzed by the haloalkane dehalogenase LinB from Sphingobium japonicum UT26 proceeds in a sequential fashion: initial formation of intermediate haloalcohols followed by a second hydrolytic step to produce the final diol. Detailed investigation of the course of the reaction revealed favored nucleophilic displacement of the sec-halogen in the first hydrolytic event with pronounced R enantioselectivity. The second hydrolysis step proceeded with a regioselectivity switch at the primary position, with preference for the S enantiomer. Because of complex competition between all eight possible reactions, intermediate haloalcohols formed with moderate to good ee ((S)-4-bromobutan-2-ol: up to 87 %). Similarly, (S)-butane-1,3-diol was formed at a maximum ee of 35 % before full hydrolysis furnished the racemic diol product. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Digital cultural heritage and its applications: case studies of Digital Mogao Grottos and Chi Lin Nunnery reconstruction

    Li, Deren; Du, Zhiqiang; Zhu, Yixuan; Wang, Tingsong

    2010-11-01

    Considerable damage has been done to the cultural heritage sites around the world ranging from natural erosion to artificial destruction. With the development of information sciences, frontier technologies are actively introduced to help protect cultural heritage sites. The new concept of a Digital Cultural Heritage has been presented for culture protection and is gradually becoming an efficient method to solve or to remit various difficult problems. This paper puts forward a digitalization method for cultural heritage sites which rationally integrates and utilizes multiform surveying measurements. These techniques have been successfully implemented into two projects, namely the Digital Mogao Grottos and the Chi Lin Nunnery reconstruction. Our results prove that the concept of and the techniques utilized in Digital Cultural Heritage can not only contribute to research, preservation, management, interpretation, and representation of cultural heritages but can also help resolve the conflicts between tourism and protection.

  8. Evidence of cation vacancy induced room temperature ferromagnetism in Li-N codoped ZnO thin films

    Zhang, B. Y. [Key Laboratory of Excited State Process, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Science, Changchun 130033 (China); School of Physics and Optoelectronic Technology, Dalian University of Technology, Dalian 116023 (China); Yao, B. [Key Laboratory of Excited State Process, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Science, Changchun 130033 (China); State Key Laboratory of Superhard Material, Department of Physics, Jilin University, Changchun 130023 (China); Li, Y. F.; Xing, G. Z. [State Key Laboratory of Superhard Material, Department of Physics, Jilin University, Changchun 130023 (China); Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore); Liu, A. M. [School of Physics and Optoelectronic Technology, Dalian University of Technology, Dalian 116023 (China); Zhang, Z. Z.; Li, B. H.; Zhao, D. X.; Shan, C. X.; Shen, D. Z. [Key Laboratory of Excited State Process, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Science, Changchun 130033 (China); Wu, T. [Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore); Qin, X. B. [Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China)

    2011-10-31

    Room temperature ferromagnetism (RTFM) was observed in Li-N codoped ZnO thin films [ZnO:(Li, N)] fabricated by plasma-assisted molecular beam epitaxy, and p-type ZnO:(Li, N) shows the strongest RTFM. Positron annihilation spectroscopy and low temperature photoluminescence measurements indicate that the RTFM in ZnO:(Li, N) is attributed to the defect complex related to V{sub Zn}, such as V{sub Zn} and Li{sub i}-N{sub O}-V{sub Zn} complex, well supported by first-principles calculations. The incorporation of N{sub O} can stabilize and enhance the RTFM of ZnO:(Li, N) by combining with Li{sub i} to form Li{sub i}-N{sub O} complex, which restrains the compensation of Li{sub i} for V{sub Zn} and makes the ZnO:(Li, N) conduct in p-type.

  9. Evidence of cation vacancy induced room temperature ferromagnetism in Li-N codoped ZnO thin films

    Zhang, B. Y.; Yao, B.; Li, Y. F.; Xing, G. Z.; Liu, A. M.; Zhang, Z. Z.; Li, B. H.; Zhao, D. X.; Shan, C. X.; Shen, D. Z.; Wu, T.; Qin, X. B.

    2011-01-01

    Room temperature ferromagnetism (RTFM) was observed in Li-N codoped ZnO thin films [ZnO:(Li, N)] fabricated by plasma-assisted molecular beam epitaxy, and p-type ZnO:(Li, N) shows the strongest RTFM. Positron annihilation spectroscopy and low temperature photoluminescence measurements indicate that the RTFM in ZnO:(Li, N) is attributed to the defect complex related to V Zn , such as V Zn and Li i -N O -V Zn complex, well supported by first-principles calculations. The incorporation of N O can stabilize and enhance the RTFM of ZnO:(Li, N) by combining with Li i to form Li i -N O complex, which restrains the compensation of Li i for V Zn and makes the ZnO:(Li, N) conduct in p-type.

  10. Evidence of cation vacancy induced room temperature ferromagnetism in Li-N codoped ZnO thin films

    Zhang, B. Y.; Yao, B.; Li, Y. F.; Liu, A. M.; Zhang, Z. Z.; Li, B. H.; Xing, G. Z.; Wu, T.; Qin, X. B.; Zhao, D. X.; Shan, C. X.; Shen, D. Z.

    2011-10-01

    Room temperature ferromagnetism (RTFM) was observed in Li-N codoped ZnO thin films [ZnO:(Li, N)] fabricated by plasma-assisted molecular beam epitaxy, and p-type ZnO:(Li, N) shows the strongest RTFM. Positron annihilation spectroscopy and low temperature photoluminescence measurements indicate that the RTFM in ZnO:(Li, N) is attributed to the defect complex related to VZn, such as VZn and Lii-NO-VZn complex, well supported by first-principles calculations. The incorporation of NO can stabilize and enhance the RTFM of ZnO:(Li, N) by combining with Lii to form Lii-NO complex, which restrains the compensation of Lii for VZn and makes the ZnO:(Li, N) conduct in p-type.

  11. An Extension of the Lin-Kernighan-Helsgaun TSP Solver for Constrained Traveling Salesman and Vehicle Routing Problems

    Helsgaun, Keld

    This report describes the implementation of an extension of the Lin-Kernighan-Helsgaun TSP solver for solving constrained traveling salesman and vehicle routing problems. The extension, which is called LKH-3, is able to solve a variety of well-known problems, including the sequential ordering...... problem (SOP), the traveling repairman problem (TRP), variants of the multiple travel-ing salesman problem (mTSP), as well as vehicle routing problems (VRPs) with capacity, time windows, pickup-and-delivery and distance constraints. The implementation of LKH-3 builds on the idea of transforming...... the problems into standard symmetric traveling salesman problems and handling constraints by means of penalty functions. Extensive testing on benchmark instances from the literature has shown that LKH-3 is effective. Best known solutions are often obtained, and in some cases, new best solutions are found...

  12. ''SMILE'': A Self Magnetically Insulated Transmission LinE adder for the 8-stage RADLAC II accelerator

    Mazarakis, M.G.; Poukey, J.W.; Shope, S.L.; Frost, C.A.; Turman, B.N.; Ramirez, J.J.; Prestwich, K.R.; Pankuch, P.J.

    1991-01-01

    The RADLAC II Self Magnetically Insulated Transmission LinE ''SMILE'' is a coaxial wave guide structure that is composed of two regions: (a) a 9.5-m voltage adder and (b) a 3-m long extension section. The adder section provides for the addition of the input voltages from the individual water-dielectric pulse forming line feeds. The extension section isolates the adder from the magnetically immersed foilless diode electron source load and efficiently transports the pulsed power out from the deionized water tank of the device. The SMILE modification of the RADLAC II accelerator enabled us to produce high quality beams of up to 14 MV, 100 kA. The design and the experimental evaluation of SMILE will be presented and compared with numerical simulation predictions. 12 refs., 9 figs., 1 tab

  13. Expression and associations of TRAF1, BMI-1, ALDH1, and Lin28B in oral squamous cell carcinoma.

    Wu, Tian-Fu; Li, Yi-Cun; Ma, Si-Rui; Bing-Liu; Zhang, Wen-Feng; Sun, Zhi-Jun

    2017-04-01

    Tumor necrosis factor receptor-associated factor 1, an adaptor protein of tumor necrosis factor 2, is involved in classical nuclear factor (NF)-κB activation and lymphocyte recruitment. However, less is known about the expression and association of tumor necrosis factor receptor-associated factor 1 with cancer stem cell markers in oral squamous cell carcinoma. This study aimed to investigate the expression of tumor necrosis factor receptor-associated factor 1 and stem cell characteristic markers (lin28 homolog B, B cell-specific Moloney murine leukemia virus integration site 1, and aldehyde dehydrogenase 1) in oral squamous cell carcinoma and analyze their relations. Paraffin-embedded tissues of 78 oral squamous cell carcinomas, 39 normal oral mucosa, and 12 oral dysplasia tissues were employed in tissue microarrays, and the expression of tumor necrosis factor receptor-associated factor 1, B cell-specific Moloney murine leukemia virus integration site 1, aldehyde dehydrogenase 1, and lin28 homolog B was measured by immunohistostaining and digital pathological analysis. The expression of tumor necrosis factor receptor-associated factor 1 was higher in the oral squamous cell carcinoma group as compared with the expression in the oral mucosa (p oral dysplasia (p oral squamous cell carcinoma. The patient survival rate was lower in the highly expressed tumor necrosis factor receptor-associated factor 1 group, although the difference was not significant. The clustering analysis showed that tumor necrosis factor receptor-associated factor 1 was most related to aldehyde dehydrogenase 1. These findings suggest that tumor necrosis factor receptor-associated factor 1 has potential direct/indirect regulations with the cancer stem cell markers in oral squamous cell carcinoma, which may help in further analysis of the cancer stem cell characteristics.

  14. Down-regulation of CatSper1 channel in epididymal spermatozoa contributes to the pathogenesis of asthenozoospermia, whereas up-regulation of the channel by Sheng-Jing-San treatment improves the sperm motility of asthenozoospermia in rats.

    Wang, Ya-Nan; Wang, Bo; Liang, Ming; Han, Cai-Yan; Zhang, Bin; Cai, Jie; Sun, Wei; Xing, Guo-Gang

    2013-02-01

    To determine the expression of CatSper1 channel in epididymal spermatozoa in a rat model of asthenozoospermia, induced by cyclophosphamide (CP), and further examine the effects of soluble granules of Sheng-Jing-San (SJS), a traditional Chinese medicine recipe, on CatSper1 expression and sperm motility in the CP-induced asthenozoospermic rats. Placebo-controlled, randomized trial. Neuroscience Research Institute, Peking University, China. Sexually mature male Sprague-Dawley rats (n = 60). In the CP group, CP at the dose of 35 mg/kg intraperitoneally injected into rats once a day for 7 days; in the normal saline (NS) group, 0.9% saline solution was injected as control. Sperm motility and count were evaluated by computer-assisted sperm assay (CASA); protein and mRNA expression of CatSper1 channel in epididymal spermatozoa was determined by Western blotting and quantitative real-time RT-PCR, respectively. The rats were randomly divided into five groups with 12 rats in each group: CP, normal saline (NS), CP + SJS, CP + NS, and treatment naïve. In the CP + SJS group, after the last injection of CP, SJS at a dose of 30 mg/kg was intragastrically administrated to rats once a day for 14 days; in CP + NS group, saline solution instead of SJS was administrated as control. In the treatment naïve group, rats were normally fed for 21 days as controls. We found a statistically significant reduction of the CatSper1 channel, which is associated with an impairment of sperm motility in the epididymal spermatozoa of CP-induced asthenozoospermic rats. Soluble granules of SJS could dramatically restore the CP-induced down-regulation of CatSper1 in epididymal spermatozoa, which greatly improved the sperm motility in the asthenozoospermic rats. Down-regulation of the CatSper1 channel in epididymal spermatozoa likely contributes to the pathogenesis of asthenozoospermia, whereas up-regulation of the channel by SJS improves sperm motility and thus can be used as an effective therapeutic

  15. Applying a Multiple Screening Program Aided by a Guideline-driven Computerized Decision Support System—A Pilot Experience in Yun-Lin, Taiwan

    Jou-Wei Lin

    2007-01-01

    Conclusion: A computer-aided screening program driven by the US Preventive Services Task Force recommendations has been successfully implemented in Yun-Lin, Taiwan, and provided useful information about local epidemiology and implications for future health policy making. [J Formos Med Assoc 2007; 106(1:58-68

  16. Curcumin Inhibits LIN-28A through the Activation of miRNA-98 in the Lung Cancer Cell Line A549.

    Liu, Wei-Lun; Chang, Jia-Ming; Chong, Inn-Wen; Hung, Yi-Li; Chen, Yung-Hsiang; Huang, Wen-Tsung; Kuo, Hsuan-Fu; Hsieh, Chong-Chao; Liu, Po-Len

    2017-06-03

    Metastasis is common in lung cancer and is associated with poor clinical outcomes and increased mortality. Curcumin is a natural anti-cancer agent that inhibits the metastasis of various cancers by modulating the expression of micro (mi) RNAs such as miR-98, which acts as a tumor suppressor. This study investigated the effect of curcumin on miR-98 expression and in vitro cell line growth and invasiveness in lung cancer. Curcumin treatment enhanced the expression of miR-98 and reduced that of the miR-98 target gene LIN28A as well as matrix metalloproteinase ( MMP ) 2 and MMP9 in vitro and in vivo. MiR-98 overexpression suppressed lung cancer cell migration and invasion by inhibiting LIN28A-induced MMP2 and MMP9 expression. Meanwhile, LIN28A level was downregulated by overexpression of miR-98 mimic. Induction of miR-98 by curcumin treatment suppressed MMP2 and MMP9 by targeting LIN28A. These findings provide insight into the mechanisms by which curcumin suppresses lung cancer cell line growth in vitro and in vivo and invasiveness in vitro.

  17. The gga-let-7 family post-transcriptionally regulates TGFBR1 and LIN28B during the differentiation process in early chick development.

    Lee, Sang In; Jeon, Mi-Hyang; Kim, Jeom Sun; Jeon, Ik-Soo; Byun, Sung June

    2015-12-01

    Early chick embryogenesis is governed by a complex mechanism involving transcriptional and post-transcriptional regulation, although how post-transcriptional processes influence the balance between pluripotency and differentiation during early chick development have not been previously investigated. Here, we characterized the microRNA (miRNA) signature associated with differentiation in the chick embryo, and found that as expression of the gga-let-7 family increases through early development, expression of their direct targets, TGFBR1 and LIN28B, decreases; indeed, gga-let-7a-5p and gga-let-7b miRNAs directly bind to TGFBR1 and LIN28B transcripts. Our data further indicate that TGFBR1 and LIN28B maintain pluripotency by regulating POUV, NANOG, and CRIPTO. Therefore, gga-let-7 miRNAs act as post-transcriptional regulators of differentiation in blastodermal cells by repressing the expression of the TGFBR1 and LIN28B, which intrinsically controls blastodermal cell differentiation in early chick development. © 2015 Wiley Periodicals, Inc.

  18. The Many Sides of Happy Lim: aka Hom Ah Wing, Lin Jian Fu, Happy Lum, Lin Chien Fu, Hom Yen Chuck, Lam Kin Foo, Lum Kin Foo, Hom, Lim Goon Wing, Lim Gin Foo, Gin Foo Lin, Koon Wing Lim, Henry Chin, Lim Ying Chuck, Lim Ah Wing, et. al.

    Gordon H. Chang

    2010-03-01

    Full Text Available

    Known to the FBI, INS, and IRS as Mr. Ah Wing Hom, he was also Lin Jian Fu, Jian Fu (Tough Guy, or just Fu to the readers of the many poems and short stories he published in Chinese over four decades in the twentieth century. And to still others, primarily English-readers of his writing, he was Happy Lim, an ironic, even tragically bizarre name, as his life was far from pleasant. On New Year's Day 1986, he died alone in a dingy San Francisco Chinatown bachelor hotel suffering from a bacterial infection and a chronic blood disorder that had required the amputation of all his toes the year before. He was seventy-eight years of age and had spent most of his life within blocks of where he died.

  19. Functional study of risk loci of stem cell-associated gene lin-28B and associations with disease survival outcomes in epithelial ovarian cancer.

    Lu, Lingeng; Katsaros, Dionyssios; Mayne, Susan T; Risch, Harvey A; Benedetto, Chiara; Canuto, Emilie Marion; Yu, Herbert

    2012-11-01

    Several single-nucleotide polymorphisms (SNPs) of the stem cell-associated gene lin-28B have been identified in association with ovarian cancer and ovarian cancer-related risk factors. However, whether these SNPs are functional or might be potential biomarkers for ovarian cancer prognosis remains unknown. The purposes of this study were to investigate the functional relevance of the identified lin-28B SNPs, as well as the associations of genotype and phenotype with epithelial ovarian cancer (EOC) survival. We analyzed five SNPs and mRNA levels of lin-28B in 211 primary EOC tissues using Taqman(®) SNP genotyping assays and SYBR green-based real-time PCR, respectively. The RNA secondary structures at the region of a genome-wide association-identified intronic rs314276 were analyzed theoretically with mfold and experimentally with circular dichroism spectroscopy. We found that rs314276 was a cis-acting expression quantitative trait locus (eQTL) in both additive and dominant models, while rs7759938 and rs314277 were significant or of borderline significance in dominant models only. The rs314276 variant significantly affects RNA secondary structure. No SNPs alone were associated with patient survival. However, we found that among patients initially responding to chemotherapy, those with higher lin-28B expression had higher mortality risk (hazard ratio =3.27, 95% confidence interval: 1.63-6.56) and relapse risk (hazard ratio = 2.53, 95% confidence interval: 1.41-4.54) than those with lower expression, and these associations remained in multivariate analyses. These results suggest that rs314276 alters RNA secondary structure and thereby influences gene expression, and that lin-28B is a cancer stem cell-associated marker, which may be a pharmaceutical target in the management of EOC.

  20. CINCO VOZES NUM COTIDIANO DE SOMBRAS: “PENTÁGONO DE HAHN”, DE OSMAN LINS

    Cícero Émerson do Nascimento Cardoso (URCA

    2013-11-01

    Full Text Available Este trabalho se pauta na análise da obra “Pentágono de Hahn”, que integra a obra “Nove, novena – narrativas”, de Osman Lins. A partir da chegada de um circo a uma cidade interiorana que apresenta, dentre seus espetáculos, a elefanta “Hahn”, cinco personagens expõem suas existências fadadas à brutalidade de um cotidiano “repleto” de vazios e experiências não vividas. O autor, nessa obra, arquiteta uma enredística polifônica que excede em lirismo, acuidade psicológica e catalogação de valores humanos indevassáveis o que a torna um profícuo objeto de estudo aberto às mais amplas incursões em se tratando de produção literária moderna.

    Palavras-chave: Modernismo; Narrativa moderna; Osman Lins.

  1. Loss of the Caenorhabditis elegans pocket protein LIN-35 reveals MuvB's innate function as the repressor of DREAM target genes.

    Paul D Goetsch

    2017-11-01

    Full Text Available The DREAM (Dp/Retinoblastoma(Rb-like/E2F/MuvB transcriptional repressor complex acts as a gatekeeper of the mammalian cell cycle by establishing and maintaining cellular quiescence. How DREAM's three functional components, the E2F-DP heterodimer, the Rb-like pocket protein, and the MuvB subcomplex, form and function at target gene promoters remains unknown. The current model invokes that the pocket protein links E2F-DP and MuvB and is essential for gene repression. We tested this model by assessing how the conserved yet less redundant DREAM system in Caenorhabditis elegans is affected by absence of the sole C. elegans pocket protein LIN-35. Using a LIN-35 protein null mutant, we analyzed the assembly of E2F-DP and MuvB at promoters that are bound by DREAM and the level of expression of those "DREAM target genes" in embryos. We report that LIN-35 indeed mediates the association of E2F-DP and MuvB, a function that stabilizes DREAM subunit occupancy at target genes. In the absence of LIN-35, the occupancy of E2F-DP and MuvB at most DREAM target genes decreases dramatically and many of those genes become upregulated. The retention of E2F-DP and MuvB at some target gene promoters in lin-35 null embryos allowed us to test their contribution to DREAM target gene repression. Depletion of MuvB, but not E2F-DP, in the sensitized lin-35 null background caused further upregulation of DREAM target genes. We conclude that the pocket protein functions primarily to support MuvB-mediated repression of DREAM targets and that transcriptional repression is the innate function of the evolutionarily conserved MuvB complex. Our findings provide important insights into how mammalian DREAM assembly and disassembly may regulate gene expression and the cell cycle.

  2. Crystal structures of MW1337R and lin2004: Representatives of a novel protein family that adopt a four-helical bundle fold

    Kozbial, Piotr; Xu, Qingping; Chiu, Hsiu-Ju; McMullan, Daniel; Krishna, S. Sri; Miller, Mitchell D.; Abdubek, Polat; Acosta, Claire; Astakhova, Tamara; Axelrod, Herbert L.; Carlton, Dennis; Clayton, Thomas; Deller, Marc; Duan, Lian; Elias, Ylva; Elsliger, Marc-André; Feuerhelm, Julie; Grzechnik, Slawomir K.; Hale, Joanna; Han, Gye Won; Jaroszewski, Lukasz; Jin, Kevin K.; Klock, Heath E.; Knuth, Mark W.; Koesema, Eric; Kumar, Abhinav; Marciano, David; Morse, Andrew T.; Murphy, Kevin D.; Nigoghossian, Edward; Okach, Linda; Oommachen, Silvya; Reyes, Ron; Rife, Christopher L.; Spraggon, Glen; Trout, Christina V.; ban den Bedem, Henry; Weekes, Dana; White, Aprilfawn; Wolf, Guenter; Zubieta, Chloe; Hodgson, Keith O.; Wooley, John; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A. (Scripps); (SSRL); (JCSG); (UCSD); (Burnham)

    2009-08-28

    To extend the structural coverage of proteins with unknown functions, we targeted a novel protein family (Pfam accession number PF08807, DUF1798) for which we proposed and determined the structures of two representative members. The MW1337R gene of Staphylococcus aureus subsp. aureus Rosenbach (Wood 46) encodes a protein with a molecular weight of 13.8 kDa (residues 1-116) and a calculated isoelectric point of 5.15. The lin2004 gene of the nonspore-forming bacterium Listeria innocua Clip11262 encodes a protein with a molecular weight of 14.6 kDa (residues 1-121) and a calculated isoelectric point of 5.45. MW1337R and lin2004, as well as their homologs, which, so far, have been found only in Bacillus, Staphylococcus, Listeria, and related genera (Geobacillus, Exiguobacterium, and Oceanobacillus), have unknown functions and are annotated as hypothetical proteins. The genomic contexts of MW1337R and lin2004 are similar and conserved in related species. In prokaryotic genomes, most often, functionally interacting proteins are coded by genes, which are colocated in conserved operons. Proteins from the same operon as MW1337R and lin2004 either have unknown functions (i.e., belong to DUF1273, Pfam accession number PF06908) or are similar to ypsB from Bacillus subtilis. The function of ypsB is unclear, although it has a strong similarity to the N-terminal region of DivIVA, which was characterized as a bifunctional protein with distinct roles during vegetative growth and sporulation. In addition, members of the DUF1273 family display distant sequence similarity with the DprA/Smf protein, which acts downstream of the DNA uptake machinery, possibly in conjunction with RecA. The RecA activities in Bacillus subtilis are modulated by RecU Holliday-junction resolvase. In all analyzed cases, the gene coding for RecU is in the vicinity of MW1337R, lin2004, or their orthologs, but on a different operon located in the complementary DNA strand. Here, we report the crystal structures

  3. Safety and Feasibility of Lin- Cells Administration to ALS Patients: A Novel View on Humoral Factors and miRNA Profiles

    Anna Sobuś

    2018-04-01

    Full Text Available Therapeutic options for amyotrophic lateral sclerosis (ALS are still limited. Great hopes, however, are placed in growth factors that show neuroprotective abilities (e.g., nerve growth factor (NGF, brain-derived neurotrophic factor (BDNF, and vascular endothelial growth factor (VEGF and in the immune modulating features, in particular, the anti-inflammatory effects. In our study we aimed to investigate whether a bone marrow-derived lineage-negative (Lin- cells population, after autologous application into cerebrospinal fluid (CSF, is able to produce noticeable concentrations of trophic factors and inflammatory-related proteins and thus influence the clinical course of ALS. To our knowledge, the evaluation of Lin- cells transplantation for ALS treatment has not been previously reported. Early hematopoietic Lin- cells were isolated from twelve ALS patients’ bone marrow, and later, the suspension of cells was administered into the subarachnoid space by lumbar puncture. Concentrations of selected proteins in the CSF and plasma were quantified by multiplex fluorescent bead-based immunoassays at different timepoints post-transplantation. We also chose microRNAs (miRNAs related to muscle biology (miRNA-1, miRNA-133a, and miRNA-206 and angiogenesis and inflammation (miRNA-155 and miRNA-378 and tested, for the first time, their expression profiles in the CSF and plasma of ALS patients after Lin- cells transplantation. The injection of bone marrow cells resulted in decreased concentration of selected inflammatory proteins (C3 after Lin- cells injection, particularly in patients who had a better clinical outcome. Moreover, several analyzed miRNAs have changed expression levels in the CSF and plasma of ALS patients subsequent to Lin- cells administration. Interestingly, the expression of miR-206 increased in ALS patients, while miR-378 decreased both in the CSF and plasma one month after the cells’ injection. We propose that autologous lineage

  4. Safety and Feasibility of Lin- Cells Administration to ALS Patients: A Novel View on Humoral Factors and miRNA Profiles.

    Sobuś, Anna; Baumert, Bartłomiej; Litwińska, Zofia; Gołąb-Janowska, Monika; Stępniewski, Jacek; Kotowski, Maciej; Pius-Sadowska, Ewa; Kawa, Miłosz P; Gródecka-Szwajkiewicz, Dorota; Peregud-Pogorzelski, Jarosław; Dulak, Józef; Nowacki, Przemysław; Machaliński, Bogusław

    2018-04-27

    Therapeutic options for amyotrophic lateral sclerosis (ALS) are still limited. Great hopes, however, are placed in growth factors that show neuroprotective abilities (e.g., nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF)) and in the immune modulating features, in particular, the anti-inflammatory effects. In our study we aimed to investigate whether a bone marrow-derived lineage-negative (Lin-) cells population, after autologous application into cerebrospinal fluid (CSF), is able to produce noticeable concentrations of trophic factors and inflammatory-related proteins and thus influence the clinical course of ALS. To our knowledge, the evaluation of Lin- cells transplantation for ALS treatment has not been previously reported. Early hematopoietic Lin- cells were isolated from twelve ALS patients’ bone marrow, and later, the suspension of cells was administered into the subarachnoid space by lumbar puncture. Concentrations of selected proteins in the CSF and plasma were quantified by multiplex fluorescent bead-based immunoassays at different timepoints post-transplantation. We also chose microRNAs (miRNAs) related to muscle biology (miRNA-1, miRNA-133a, and miRNA-206) and angiogenesis and inflammation (miRNA-155 and miRNA-378) and tested, for the first time, their expression profiles in the CSF and plasma of ALS patients after Lin- cells transplantation. The injection of bone marrow cells resulted in decreased concentration of selected inflammatory proteins (C3) after Lin- cells injection, particularly in patients who had a better clinical outcome. Moreover, several analyzed miRNAs have changed expression levels in the CSF and plasma of ALS patients subsequent to Lin- cells administration. Interestingly, the expression of miR-206 increased in ALS patients, while miR-378 decreased both in the CSF and plasma one month after the cells’ injection. We propose that autologous lineage-negative early

  5. Synthèse et validation d'une loi de commande linéaire robuste de braquage d'une automobile

    MENHOUR, Lghani; LECHNER, Daniel; CHARARA, Ali

    2010-01-01

    Ce papier propose la synthèse d'un retour d'état robuste préprogrammé pour le contrôle de direction d'un véhicule. Celui-ci est utilisé pour simuler le comportement du véhicule sous des fortes sollicitations dynamiques. Les contraintes d'inégalités matricielles linéaires (LMI) et un modèle linéaire à paramètres variants sont utilisés pour la synthèse du retour d'état. Ensuite, une méthode d'interpolation des gains est utilisée pour la conception d'un retour d'état robuste préprogrammé. La str...

  6. Tip 2 Diabetes Mellituslu Hastalarda Mikroalbuminüri, İnsülin Direnci ve Kardiyovasküler Risk

    ERSOY, Canan; TAŞLI, Babürşah; YILDIZ, Abdülmecit; İMAMOĞLU, Şazi

    2006-01-01

    Son çalışmalar tip 2 diyabette mikroalbuminüri (MAU) varlığı ile hedef organ hasarları ve kardiyovasküler hastalık riski arasındaki ilişkilere yönelmişlerdir. Bu çalışmada, Tip 2 diabetes mellituslu (DM) hastalarda MAU ile glisemik kontrol, insülin direnci (İR) ve diğer kardiyovasküler risk faktörleri arasındaki ilişki değerlendirilmiştir. İnsülin gereksinimi olmayan, normal renal fonksiyonlu 29 mikroalbuminürik ve 68 normoalbuminürik tip 2 DM'lu hasta çalışmaya dahil edildi. Tüm hast...

  7. Lin- CD34hi CD117int/hi FcεRI+ cells in human blood constitute a rare population of mast cell progenitors.

    Dahlin, Joakim S; Malinovschi, Andrei; Öhrvik, Helena; Sandelin, Martin; Janson, Christer; Alving, Kjell; Hallgren, Jenny

    2016-01-28

    Mast cells are rare tissue-resident immune cells that are involved in allergic reactions, and their numbers are increased in the lungs of asthmatics. Murine lung mast cells arise from committed bone marrow-derived progenitors that enter the blood circulation, migrate through the pulmonary endothelium, and mature in the tissue. In humans, mast cells can be cultured from multipotent CD34(+) progenitor cells. However, a population of distinct precursor cells that give rise to mast cells has remained undiscovered. To our knowledge, this is the first report of human lineage-negative (Lin(-)) CD34(hi) CD117(int/hi) FcεRI(+) progenitor cells, which represented only 0.0053% of the isolated blood cells in healthy individuals. These cells expressed integrin β7 and developed a mast cell-like phenotype, although with a slow cell division capacity in vitro. Isolated Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood cells had an immature mast cell-like appearance and expressed high levels of many mast cell-related genes as compared with human blood basophils in whole-transcriptome microarray analyses. Furthermore, serglycin, tryptase, and carboxypeptidase A messenger RNA transcripts were detected by quantitative reverse transcription-polymerase chain reaction. Altogether, we propose that the Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood cells are closely related to human tissue mast cells and likely constitute an immediate precursor population, which can give rise to predominantly mast cells. Furthermore, asthmatics with reduced lung function had a higher frequency of Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood mast cell progenitors than asthmatics with normal lung function. © 2016 by The American Society of Hematology.

  8. Weak Activity of Haloalkane Dehalogenase LinB with 1,2,3-Trichloropropane Revealed by X-Ray Crystallography and Microcalorimetry▿

    Monincová, Marta; Prokop, Zbyněk; Vévodová, Jitka; Nagata, Yuji; Damborský, Jiří

    2007-01-01

    1,2,3-Trichloropropane (TCP) is a highly toxic and recalcitrant compound. Haloalkane dehalogenases are bacterial enzymes that catalyze the cleavage of a carbon-halogen bond in a wide range of organic halogenated compounds. Haloalkane dehalogenase LinB from Sphingobium japonicum UT26 has, for a long time, been considered inactive with TCP, since the reaction cannot be easily detected by conventional analytical methods. Here we demonstrate detection of the weak activity (kcat = 0.005 s−1) of Li...

  9. Functional comparison of the nematode Hox gene lin-39 in C. elegans and P. pacificus reveals evolutionary conservation of protein function despite divergence of primary sequences

    Grandien, Kaj; Sommer, Ralf J.

    2001-01-01

    Hox transcription factors have been implicated in playing a central role in the evolution of animal morphology. Many studies indicate the evolutionary importance of regulatory changes in Hox genes, but little is known about the role of functional changes in Hox proteins. In the nematodes Pristionchus pacificus and Caenorhabditis elegans, developmental processes can be compared at the cellular, genetic, and molecular levels and differences in gene function can be identified. The Hox gene lin-3...

  10. Qualidade de um sistema latossolo-argissolo como receptor de efluentes no município de Lins(SP Quality of a latosol-argisol system in the county of Lins/SP, Brazil

    Liliane Ibrahim

    2008-12-01

    Full Text Available Este trabalho objetivou caracterizar um sistema de solos, evidenciando a propriedades que possam esclarecer sua dinâmica e contribuir para a definição de critérios que condicionem a aptidão destes solos como receptores de efluentes. Trata-se de uma área experimental de estudos, contígua à Estação de Tratamento de Esgoto do município de Lins (SP, onde o efluente é gerado a partir do tratamento de esgoto por sistema de lagoas de estabilização. Os solos, situados ao longo de uma vertente com ligeira inclinação, foram caracterizados por meio de análises, morfológica, granulométrica, química, mineralógica e micromorfológica, realizadas em amostras coletadas em cinco trincheiras em toposseqüência. Os solos são desenvolvidos a partir dos sedimentos arenosos da Formação Adamantina (Grupo Bauru e constituem um sistema Latossolo - Argissolo onde a transição Bw - Bt ocorre lateralmente do topo para a base da vertente. Foram identificadas três fases pedogenéticas nesta associação de solos. A primeira, argiluviação e adensamento de partículas, responsável pela formação dos horizontes texturais, foi superposta pelos processos de latossolização e hidromorfismo, atuantes na dinâmica atual destes solos. Análises micromorfológicas mostraram tratar-se de solos com intensa porosidade, caracterizada pelo empilhamento dos grãos do esqueleto quartzoso amplamente predominante e pelo arranjo entre os microagregados granulares. A permeabilidade é ainda favorecida pela intensa ação da mesofauna. Os solos são distróficos e compostos por caulinita e óxidos de Fe na fração argilosa. Por constituírem um sistema frágil, a disposição de quaisquer tipos de resíduos nestes solos requer o monitoramento constante de suas propriedades, tanto para a manutenção, quanto para a recuperação da qualidade desta cobertura pedológica.The purpose of this study was the characterization of a soil system, focused on proprieties that

  11. Properties of the fullerene C_6_0-containing PN Lin49 in the SMC; Explanations of strong near-IR excess

    Otsuka, Masaaki; Kemper, Francisca; Leal-Ferreira, Marcelo L.; Aleman, Isabel; Ochsendorf, Bram; Bernard-Salas, Jeronimo; Cami, Jan; Peeters, Els

    2016-01-01

    We performed a detailed spectroscopic analysis of the fullerene C_6o-containing planetary nebula (PN) Lin49 in the Small Magellanic Cloud (SMC). Lin49 is a C-rich and metal- deficient PN (Z∼⃒0.0006) and its nebular abundances are in agreement with the AGB model for the initially 1.25M_☉ stars with the metallicity Z = 0.001 of Fishlock et al. (2014, [1]). By stellar absorption fitting with TLUSTY, we derived stellar abundances, effective temperature, and surface gravity. We constructed the photo-ionization model with CLOUDY in order to investigate physical conditions of Lin49. The model with the 0.005-0.1 μm radius graphite and a constant hydrogen density shell could not fit the ∼⃒1-5 μm SED owing to the strong near-IR excess. We propose that the near-IR excess indicates (1) the presence of extremely small carbon molecules or (2) the presence of high-density structure surrounding the central star. (paper)

  12. Initial results on computational performance of Intel Many Integrated Core (MIC) architecture: implementation of the Weather and Research Forecasting (WRF) Purdue-Lin microphysics scheme

    Mielikainen, Jarno; Huang, Bormin; Huang, Allen H.

    2014-10-01

    Purdue-Lin scheme is a relatively sophisticated microphysics scheme in the Weather Research and Forecasting (WRF) model. The scheme includes six classes of hydro meteors: water vapor, cloud water, raid, cloud ice, snow and graupel. The scheme is very suitable for massively parallel computation as there are no interactions among horizontal grid points. In this paper, we accelerate the Purdue Lin scheme using Intel Many Integrated Core Architecture (MIC) hardware. The Intel Xeon Phi is a high performance coprocessor consists of up to 61 cores. The Xeon Phi is connected to a CPU via the PCI Express (PICe) bus. In this paper, we will discuss in detail the code optimization issues encountered while tuning the Purdue-Lin microphysics Fortran code for Xeon Phi. In particularly, getting a good performance required utilizing multiple cores, the wide vector operations and make efficient use of memory. The results show that the optimizations improved performance of the original code on Xeon Phi 5110P by a factor of 4.2x. Furthermore, the same optimizations improved performance on Intel Xeon E5-2603 CPU by a factor of 1.2x compared to the original code.

  13. Effects of gamma radiation on various stages in the life cycle of meal worm, Tenebrio molitor Lin

    Chiravathanapong, S.; Segsarnviriya, S.

    1984-12-01

    Effect of gamma radiation on each growth stage of meal worm (Tenebrio molitor Lin.) were conducted at 27+-2 0 C and 75+-2% relative humidity. LD 50 and LD 99 of 5-day old eggs at 5 days after irradiation were 76 and 367 gray. The survived larvae could live no longer than 5 days and seldom moved or without feeding. LD 50 and LD 99 of last instar larvae at 10 days after irradiation were 662 and 1,367 gray. No pupation occurred in larvae after irradiation. Dead larvae caused by radiation turned blackish, liquid oozed out from the body, and survived no longer than 5 days. Some irradiated larvae had incomplete molting and died. LD 50 and LD 99 of 6-day-old pupae at 3 days after irradiation were 874 and 1,492 gray. Abnormal irradiated pupae, some abnormal pupae were underdeveloped wing and abdominal pupal characteristic was still remained. Pupal legs could develop to adult legs only and could survive no longer than 1 week. Unfortunately pupae irradiated at low dosage of radiation would develop to be complete adult head, but could survive no longer than 2 weeks with slow movement and no oviposition. LD 50 of male adults and female adults was checked in 7 days postirradiation and it was estimated as 788 and 786 gray while LD 99 was estimated as 1,375 and 1,350 gray respectively. Results of male adults and female adults checking in 10 days post-irradiation found that LD 50 was estimated as 533 and 598 gray and LD 99 was estimated as 1,227 and 1,229 gray respectively. The remained survivors of both sexes could survive no longer than 10 days without feeding and mating

  14. Lithology identification of aquifers from geophysical well logs and fuzzy logic analysis: Shui-Lin Area, Taiwan

    Hsieh, Bieng-Zih; Lewis, Charles; Lin, Zsay-Shing

    2005-04-01

    The purpose of this study is to construct a fuzzy lithology system from well logs to identify formation lithology of a groundwater aquifer system in order to better apply conventional well logging interpretation in hydro-geologic studies because well log responses of aquifers are sometimes different from those of conventional oil and gas reservoirs. The input variables for this system are the gamma-ray log reading, the separation between the spherically focused resistivity and the deep very-enhanced resistivity curves, and the borehole compensated sonic log reading. The output variable is groundwater formation lithology. All linguistic variables are based on five linguistic terms with a trapezoidal membership function. In this study, 50 data sets are clustered into 40 training sets and 10 testing sets for constructing the fuzzy lithology system and validating the ability of system prediction, respectively. The rule-based database containing 12 fuzzy lithology rules is developed from the training data sets, and the rule strength is weighted. A Madani inference system and the bisector of area defuzzification method are used for fuzzy inference and defuzzification. The success of training performance and the prediction ability were both 90%, with the calculated correlation of training and testing equal to 0.925 and 0.928, respectively. Well logs and core data from a clastic aquifer (depths 100-198 m) in the Shui-Lin area of west-central Taiwan are used for testing the system's construction. Comparison of results from core analysis, well logging and the fuzzy lithology system indicates that even though the well logging method can easily define a permeable sand formation, distinguishing between silts and sands and determining grain size variation in sands is more subjective. These shortcomings can be improved by a fuzzy lithology system that is able to yield more objective decisions than some conventional methods of log interpretation.

  15. Gene expression profile and functionality of ESC-derived Lin-ckit+Sca-1+ cells are distinct from Lin-ckit+Sca-1+ cells isolated from fetal liver or bone marrow.

    Irina Fernandez

    Full Text Available In vitro bioreactor-based cultures are being extensively investigated for large-scale production of differentiated cells from embryonic stem cells (ESCs. However, it is unclear whether in vitro ESC-derived progenitors have similar gene expression profiles and functionalities as their in vivo counterparts. This is crucial in establishing the validity of ESC-derived cells as replacements for adult-isolated cells for clinical therapies. In this study, we compared the gene expression profiles of Lin-ckit+Sca-1+ (LKS cells generated in vitro from mouse ESCs using either static or bioreactor-based cultures, with that of native LKS cells isolated from mouse fetal liver (FL or bone marrow (BM. We found that in vitro-generated LKS cells were more similar to FL- than to BM LKS cells in gene expression. Further, when compared to cells derived from bioreactor cultures, static culture-derived LKS cells showed fewer differentially expressed genes relative to both in vivo LKS populations. Overall, the expression of hematopoietic genes was lower in ESC-derived LKS cells compared to cells from BM and FL, while the levels of non-hematopoietic genes were up-regulated. In order to determine if these molecular profiles correlated with functionality, we evaluated ESC-derived LKS cells for in vitro hematopoietic-differentiation and colony formation (CFU assay. Although static culture-generated cells failed to form any colonies, they did differentiate into CD11c+ and B220+ cells indicating some hematopoietic potential. In contrast, bioreactor-derived LKS cells, when differentiated under the same conditions failed to produce any B220+ or CD11c+ cells and did not form colonies, indicating that these cells are not hematopoietic progenitors. We conclude that in vitro culture conditions significantly affect the transcriptome and functionality of ESC-derived LKS cells and although in vitro differentiated LKS cells were lineage negative and expressed both ckit and Sca-1

  16. ALLIUM HOOKERII LIN

    Toshiba

    increase the food supply and add variety to the diet [5]. ... available in the Himalayan range including Nepal, China [6]. ... altitude, between 93.42oE to 94.47oE longitude and between 23.83 o ... The leaf decoction (Decoction is a method of extraction, by boiling, or ..... Dry fish washed in water are fried in a small amount of.

  17. Lin Simpson | NREL

    technology areas that included: nanotechnology, nanomaterials, thin-film photovoltaics, thin-film processing , and program management. This includes extensive experience in nanotechnology, materials science B.S., Engineering Physics, Colorado School of Mines. Thesis: Spatial filtering for pattern recognition

  18. Temporal variation and source identification of black carbon at Lin'an and Longfengshan regional background stations in China

    Cheng, Siyang; Wang, Yaqiang; An, Xingqin

    2017-12-01

    Black carbon (BC) is a component of fine particulate matter (PM2.5), associated with climate, weather, air quality, and people's health. However, studies on temporal variation of atmospheric BC concentration at background stations in China and its source area identification are lacking. In this paper, we use 2-yr BC observations from two background stations, Lin'an (LAN) and Longfengshan (LFS), to perform the investigation. The results show that the mean diurnal variation of BC has two significant peaks at LAN while different characteristics are found in the BC variation at LFS, which are probably caused by the difference in emission source contributions. Seasonal variation of monthly BC shows double peaks at LAN but a single peak at LFS. The annual mean concentrations of BC at LAN and LFS decrease by 1.63 and 0.26 μg m-3 from 2009 to 2010, respectively. The annual background concentration of BC at LAN is twice higher than that at LFS. The major source of the LAN BC is industrial emission while the source of the LFS BC is residential emission. Based on transport climatology on a 7-day timescale, LAN and LFS stations are sensitive to surface emissions respectively in belt or approximately circular area, which are dominated by summer monsoon or colder land air flows in Northwest China. In addition, we statistically analyze the BC source regions by using BC observation and FLEXible PARTicle dispersion model (FLEXPART) simulation. In summer, the source regions of BC are distributed in the northwest and south of LAN and the southwest of LFS. Low BC concentration is closely related to air mass from the sea. In winter, the source regions of BC are concentrated in the west and south of LAN and the northeast of the threshold area of s tot at LFS. The cold air mass in the northwest plays an important role in the purification of atmospheric BC. On a yearly scale, sources of BC are approximately from five provinces in the northwest/southeast of LAN and the west of LFS. These

  19. N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b.

    Rebecca Cotterman

    2009-06-01

    Full Text Available myc genes are best known for causing tumors when overexpressed, but recent studies suggest endogenous myc regulates pluripotency and self-renewal of stem cells. For example, N-myc is associated with a number of tumors including neuroblastoma, but also plays a central role in the function of normal neural stem and precursor cells (NSC. Both c- and N-myc also enhance the production of induced pluripotent stem cells (iPSC and are linked to neural tumor stem cells. The mechanisms by which myc regulates normal and neoplastic stem-related functions remain largely open questions. Here from a global, unbiased search for N-Myc bound genes using ChIP-chip assays in neuroblastoma, we found lif as a putative N-Myc bound gene with a number of strong N-Myc binding peaks in the promoter region enriched for E-boxes. Amongst putative N-Myc target genes in expression microarray studies in neuroblastoma we also found lif and three additional important embryonic stem cell (ESC-related factors that are linked to production of iPSC: klf2, klf4, and lin28b. To examine the regulation of these genes by N-Myc, we measured their expression using neuroblastoma cells that contain a Tet-regulatable N-myc transgene (TET21N as well as NSC with a nestin-cre driven N-myc knockout. N-myc levels closely correlated with the expression of all of these genes in neuroblastoma and all but lif in NSC. Direct ChIP assays also indicate that N-Myc directly binds the lif promoter. N-Myc regulates trimethylation of lysine 4 of histone H3 in the promoter of lif and possibly in the promoters of several other stem-related genes. Together these findings indicate that N-Myc regulates overlapping stem-related gene expression programs in neuroblastoma and NSC, supporting a novel model by which amplification of the N-myc gene may drive formation of neuroblastoma. They also suggest mechanisms by which Myc proteins more generally contribute to maintenance of pluripotency and self-renewal of ESC as

  20. Reducing drug–herb interaction risk with a computerized reminder system

    Lin SS

    2015-02-01

    Full Text Available Sheng-Shing Lin,1,2 Chiu-Lin Tsai,3 Ching-Yeh Tu,3 Ching-Liang Hsieh2,4,5 1Graduate Institute of Chinese Medicine, College of Chinese Medicine, China Medical University, 2Department of Chinese Medicine, China Medical University Hospital, 3Division of Chinese Medicine, Department of Pharmacy, China Medical University Hospital, 4Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, 5Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung, Taiwan Background: Traditional Chinese medicine (TCM and Western medicine are both popular in Taiwan. Approximately 14.1% of Taiwanese residents use Western drugs and Chinese herbs concurrently; therefore, drug–herb interaction is critical to patient safety. This paper presents a new procedure for reducing the risk of drug interactions.Methods: Hospital computer systems are modified to ensure that drug–herb interactions are automatically detected when a TCM practitioner is writing a prescription. A pop-up reminder appears, warning of interactions, and the practitioner may adjust doses, delete herbs, or leave the prescription unchanged. A pharmacist will receive interaction information through the system and provide health education to the patient.Results: During the 2011–2013 study period, 256 patients received 891 herbal prescriptions with potential drug–herb interactions. Three of the 50 patients who concurrently used ginseng and antidiabetic drugs manifested hypoglycemia (fasting blood sugar level ≤70 mg/dL.Conclusion: Drug–herb interactions can cause adverse reactions. A computerized reminder system can enable TCM practitioners to reduce the risk of drug–herb interactions. In addition, health education for patients is crucial in avoiding adverse reaction by the interactions. Keywords: Traditional Chinese medicine, Western medicine, adverse reaction

  1. Cell type-specific recruitment of Drosophila Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97.

    Bachmann, André; Timmer, Marco; Sierralta, Jimena; Pietrini, Grazia; Gundelfinger, Eckart D; Knust, Elisabeth; Thomas, Ulrich

    2004-04-15

    Stardust (Sdt) and Discs-Large (Dlg) are membrane-associated guanylate kinases (MAGUKs) involved in the organization of supramolecular protein complexes at distinct epithelial membrane compartments in Drosophila. Loss of either Sdt or Dlg affects epithelial development with severe effects on apico-basal polarity. Moreover, Dlg is required for the structural and functional integrity of synaptic junctions. Recent biochemical and cell culture studies have revealed that various mammalian MAGUKs can interact with mLin-7/Veli/MALS, a small PDZ-domain protein. To substantiate these findings for their in vivo significance with regard to Sdt- and Dlg-based protein complexes, we analyzed the subcellular distribution of Drosophila Lin-7 (DLin-7) and performed genetic and biochemical assays to characterize its interaction with either of the two MAGUKs. In epithelia, Sdt mediates the recruitment of DLin-7 to the subapical region, while at larval neuromuscular junctions, a particular isoform of Dlg, Dlg-S97, is required for postsynaptic localization of DLin-7. Ectopic expression of Dlg-S97 in epithelia, however, was not sufficient to induce a redistribution of DLin-7. These results imply that the recruitment of DLin-7 to MAGUK-based protein complexes is defined by cell-type specific mechanisms and that DLin-7 acts downstream of Sdt in epithelia and downstream of Dlg at synapses.

  2. Les vélins du Muséum national d’histoire naturelle : une collection mise en lumière

    Cardinal, Catherine

    2018-01-01

    Une exposition unique au Cabinet d’histoire du Jardin des plantes Très rarement, le public a pu voir la collection d’images de fleurs, de plantes, d’oiseaux et de mammifères, déposée à la bibliothèque centrale du Musée national d’histoire naturelle. La fragilité des peintures sur vélin au contact de l’air humide et de la lumière explique les précautions prises à leur égard. L’exposition d’environ cent cinquante pièces au sein du Cabinet d’histoire, d’octobre 2016 à janvier 2017, a donc consti...

  3. Efeito e modo de ação das bacteriocinas produzidas por Lactococcus lactis subsp. lactis ITAL 383, ATCC 11454 e CNRZ 150 contra Listeria innocua LIN 11 Effect and mode of action of the bacterioncin produced by Lactococcus. lactis subsp. lactis ITAL 383, ATCC 11454 e CNRZ 150 against Listeria innocua LIN 11

    Izildinha MORENO

    1999-01-01

    Full Text Available O efeito e o modo de ação das bacteriocinas produzidas por L. lactis subsp. lactis ITAL 383 e CNRZ 150 são similares à nisina de L. lactis subsp. lactis ATCC 11454. Estas bacteriocinas apresentaram um modo de ação bactericida, causando a lise de células de L. innocua LIN 11, associada ao decréscimo da absorbância e da viabilidade celular. O efeito letal foi maior para células em fase exponencial comparativamente à fase estacionária de crescimento. A adsorção dessas bacteriocinas às células de L. innocua LIN 11 foi muito rápida e influenciada pelo pH do meio de suspensão; adsorção máxima foi verificada a pH 6,0 e logo após o contato inicial. Perda completa de adsorção ocorreu em pH 2,0.The effect and mode of action of the bacteriocin produced by L. lactis subsp. lactis ITAL 383 and CNRZ 150 are similar to the nisin produced by L. lactis subsp. lactis ATCC 11454. It was clearly bactericidal, and caused lysis of a strain of L. innocua LIN 11 detected by the decrease of absorbance values and the cell viability. Their lethal effect was considerably higher during the logarithmic growth when compared to the stationary phase. Adsorption developed rapidly and was influenced by the pH value of the suspension medium. Maximum adsorption was observed at pH 6,0 and immediately after initial contact and loss at pH 2,0.

  4. Formation of positive cluster ions Li(n) Br (n = 2-7) and ionization energies studied by thermal ionization mass spectrometry.

    Veličković, S R; Đustebek, J B; Veljković, F M; Veljković, M V

    2012-05-01

    Clusters of the type Li(n)X (X = halides) can be considered as potential building blocks of cluster-assembly materials. In this work, Li(n)Br (n = 2-7) clusters were obtained by a thermal ionization source of modified design and selected by a magnetic sector mass spectrometer. Positive ions of the Li(n)Br (n = 4-7) cluster were detected for the first time. The order of ion intensities was Li(2)Br(+) > Li(4)Br(+) > Li(5)Br(+) > Li(6)Br(+) > Li(3)Br(+). The ionization energies (IEs) were measured and found to be 3.95 ± 0.20 eV for Li(2)Br, 3.92 ± 0.20 eV for Li(3)Br, 3.93 ± 0.20 eV for Li(4)Br, 4.08 ± 0.20 eV for Li(5)Br, 4.14 ± 0.20 eV for Li(6)Br and 4.19 ± 0.20 eV for Li(7)Br. All of these clusters have a much lower ionization potential than that of the lithium atom, so they belong to the superalkali class. The IEs of Li(n)Br (n = 2-4) are slightly lower than those in the corresponding small Li(n) or Li(n)H clusters, whereas the IEs of Li(n)Br are very similar to those of Li(n) or Li(n)H for n = 5 and 6. The thermal ionization source of modified design is an important means for simultaneously obtaining and measuring the IEs of Li(n)Br (n = 2-7) clusters (because their ions are hermodynamically stable with respect to the loss of lithium atoms in the gas phase) and increasingly contributes toward the development of clusters for practical applications. Copyright © 2012 John Wiley & Sons, Ltd.

  5. Quando "falha a fala" e "fala a bala": lingua(gem e violência em Cidade de Deus, de Paulo Lins

    Rita Gabrielli Pereira

    2018-04-01

    Full Text Available Cidade de Deus traz em si a história da construção do conjunto habitacional, cujo nome intitula o romance, e de sua transformação em uma das favelas mais violentas do Rio de Janeiro, por meio do entrecruzamento das histórias de Cabeleira, Bené, Zé Pequeno e Busca-Pé. Concebendo o romance, nos atos da escrita e da leitura, como uma enunciação (BENVENISTE, 1989a; 1989b; 1995a; 1995b entre autor e leitor, constituída por outras enunciações — entre narrador e narratário e entre personagens — a partir do "ato ficcional" (ISER, 2002 do autor, vamos nos guiar por essa tessitura de/entre histórias para rastrear o modo como Lins relaciona linguagem e violência. Palavras-chave: Lingua(gem, Subjetividade, Violência ______________________________ Cidade de Deus tells the history of the construction of the housing complex that entitles the novel and its transformation process into one of the most violent slums of Rio de Janeiro. By treating the novel as an enunciation (BENVENISTE, 1989a; 1989b; 1995a; 1995b between author and reader, which is made of other enunciations − between narrator and narratee and between characters −, based on the author´s “fictional act”(ISER, 2002, we intend to analyze the way how Lins relates language and violence. Keywords: Language, Subjectivity, Violence.

  6. A substrate specificity-determining unit of three Lin12-Notch repeat modules is formed in trans within the pappalysin-1 dimer and requires a sequence stretch C-terminal to the third module

    Weyer, Kathrin; Boldt, Henning B; Poulsen, Christine B

    2007-01-01

    -A cleaves IGFBP-4 and IGFBP-5, whereas PAPP-A2 cleaves only IGFBP-5. The pappalysins contain three Lin12-Notch repeat (LNR1-3) modules, previously considered unique to the Notch receptor family in which they function to regulate receptor cleavage. In contrast to the Notch receptor where three LNR modules...

  7. The Story of Heathcliff’s Journey Back to Wuthering Heights de Lin Haire-Sargeant (1992, ou le « deux en un » de la ré-écriture The Story of Heathcliff’s Journey Back to Wuthering Heights by Lin Haire-Sargeant (1992, and a “Two in one” Rewrite

    Isabelle Roblin

    2009-10-01

    Full Text Available Lin Haire-Sargeant’s 1992 novel The Story of Heathcliff’s Journey Back to Wuthering Heights is typical of the interest shown by contemporary American writers in Victorian novels. It could indeed be classified doubly as a “retro-Victorian novel” since it partly re-writes not only Emily Brontë’s most famous novel, Wuthering Heights, as the title points out, but also, somewhat less obviously, Charlotte Brontë’s Jane Eyre. We will study in this article how Lin Haire-Sargeant’s attempt at re-writing highlights the usual aims of the retro-Victorian novel: taking advantage of the blanks left by the source novels to propose to the reader a modern critical approach, while at the same time being as faithful as possible to the writing conventions of the 19th century, and suggesting another point of view on a well-known story, through a postmodern mixing of historical and fictive characters.

  8. Iodine Deficiency in a Study Population of Norwegian Pregnant Women-Results from the Little in Norway Study (LiN).

    Dahl, Lisbeth; Wik Markhus, Maria; Sanchez, Perla Vanessa Roldan; Moe, Vibeke; Smith, Lars; Meltzer, Helle Margrete; Kjellevold, Marian

    2018-04-20

    Iodine sufficiency is particularly important in pregnancy, where median urinary iodine concentration (UIC) in the range of 150⁻250 µg/L indicates adequate iodine status. The aims of this study were to determine UIC and assess if dietary and maternal characteristics influence the iodine status in pregnant Norwegian women. The study comprises a cross-sectional population-based prospective cohort of pregnant women (Little in Norway (LiN)). Median UIC in 954 urine samples was 85 µg/L and 78.4% of the samples ( n = 748) were ≤150 µg/L. 23.2% ( n = 221) of the samples were ≤50 µg/L and 5.2% ( n = 50) were above the requirements of iodine intake (>250 µg/L). Frequent iodine-supplement users ( n = 144) had significantly higher UIC (120 µg/L) than non-frequent users (75 µg/L). Frequent milk and dairy product consumers (4⁻9 portions/day) had significantly higher UIC (99 µg/L) than women consuming 0⁻1 portion/day (57 µg/L) or 2⁻3 portions/day (83 µg/L). Women living in mid-Norway ( n = 255) had lowest UIC (72 µg/L). In conclusion, this study shows that the diet of the pregnant women did not necessarily secure a sufficient iodine intake. There is an urgent need for public health strategies to secure adequate iodine nutrition among pregnant women in Norway.

  9. A Hydrological Tomography Collocated with Time-varying Gravimetry for Hydrogeology -An Example in Yun-Lin Alluvial Plain and Ming-Ju Basin in Taiwan

    Chen, K. H.; Cheng, C. C.; Hwang, C.

    2016-12-01

    A new inversion technique featured by the collocation of hydrological modeling and gravimetry observation is presented in this report. Initially this study started from a project attempting to build a sequence of hydrodynamic models of ground water system, which was applied to identify the supplement areas of alluvial plains and basins along the west coast of Taiwan. To calibrate the decent hydro-geological parameters for the modeling, geological evolution were carefully investigated and absolute gravity observations, along with other on-site hydrological monitoring data were specially introduced. It was discovered in the data processing that the time-varying gravimetrical data are highly sensitive to certain boundary conditions in the hydrodynamic model, which are correspondent with respective geological features. A new inversion technique coined by the term "hydrological tomography" is therefore developed by reversing the boundary condition into the unknowns to be solved. An example of accurate estimate for water storage and precipitation infiltration of a costal alluvial plain Yun-Lin is presented. In the mean time, the study of an anticline structure of the upstream basin Ming-Ju is also presented to demonstrate how a geological formation is outlined when the gravimetrical data and hydrodynamic model are re-directed into an inversion.

  10. Uso agrícola de esgoto tratado em lagoas de estabilização:experiências do Pprosab* em Lins – SP

    Fernando Mendonça Campos

    2004-01-01

    Full Text Available A Pilot Plant to treat the effluent from SABESP´s Wastewater Treatment Plant (Stabilization Pond System located at Lins was built within a six-hectare area adjacent to the Treatment Plant. The study focused on agricultural applications of the final treated effluent. Additional unit operations for wastewater treatment were constructed – namely hypochlorite disinfection, UV light disinfection and ozonation units. The final effluent from the Pilot Plant was applied in crop irrigation – namely coffee, corn and bean crops and the feeding system was by drop irrigation. Additionally, a fraction of the final treated effluent fed a hydrophonic system installed in vases, in which chrysanthemum and Gypsophila were cultivated. A third feeding line supplied a fish tank in which Oreochromis Niloticus were grown. A number of physical, chemical and biological variables were utilized for quality control of effluent streams at the various treatment stages, to monitor the cultivated crops and the soil, as well as agricultural parameters to identify growth characteristics. For all the cases under study there were conventional mode crops in parallel, acting as controls or references. The results obtained showed that the pond effluent, besides the hydraulic capacity itself, contained nutrients that are adequate for agricultural purposes, with significant savings associated. Additionally, such applications in irrigation avoid the eutrophication of natural water bodies

  11. Source apportionment of PM2.5 at the Lin'an regional background site in China with three receptor models

    Deng, Junjun; Zhang, Yanru; Qiu, Yuqing; Zhang, Hongliang; Du, Wenjiao; Xu, Lingling; Hong, Youwei; Chen, Yanting; Chen, Jinsheng

    2018-04-01

    Source apportionment of fine particulate matter (PM2.5) were conducted at the Lin'an Regional Atmospheric Background Station (LA) in the Yangtze River Delta (YRD) region in China from July 2014 to April 2015 with three receptor models including principal component analysis combining multiple linear regression (PCA-MLR), UNMIX and Positive Matrix Factorization (PMF). The model performance, source identification and source contribution of the three models were analyzed and inter-compared. Source apportionment of PM2.5 was also conducted with the receptor models. Good correlations between the reconstructed and measured concentrations of PM2.5 and its major chemical species were obtained for all models. PMF resolved almost all masses of PM2.5, while PCA-MLR and UNMIX explained about 80%. Five, four and seven sources were identified by PCA-MLR, UNMIX and PMF, respectively. Combustion, secondary source, marine source, dust and industrial activities were identified by all the three receptor models. Combustion source and secondary source were the major sources, and totally contributed over 60% to PM2.5. The PMF model had a better performance on separating the different combustion sources. These findings improve the understanding of PM2.5 sources in background region.

  12. Evaluación preclínica y estudio de estabilidad de extractos a partir del follaje de Momordica charantia Lin

    A. Lagarto

    2014-12-01

    Full Text Available El objetivo del presente trabajo fue la evaluación preclínica y el estudio de estabilidad de extractos a partir del follaje de Momordica charantia Lin. Se obtuvieron extractos acuoso e hidroalcohólico para los cuales se establecieron las especificaciones de calidad mediante la evaluación de tres lotes y se estudió su estabilidad por el método de vida de estante durante 12 meses. A los extractos se le evaluó el potencial genotóxico mediante ensayos de micronúcleos en médula ósea de ratón y aberraciones cromosómicas en linfocitos de sangre periférica. La actividad hipoglicemiante oral fue evaluada en animales con hiperglicemia temporal inducida por carga de glucosa. Como resultados se establecieron las especificaciones de calidad de los extractos acuoso e hidroalcohólico, los mismos mostraron estabilidad por 6 meses para el extracto acuoso y 12 meses para el extracto hidroalcohólico. No mostraron efecto genotóxico en los ensayos evaluados y mostraron efecto hipoglicemiante oral a la dosis de 450 mg/kg.

  13. Stepwise dissection and visualization of the catalytic mechanism of haloalkane dehalogenase LinB using molecular dynamics simulations and computer graphics.

    Negri, Ana; Marco, Esther; Damborsky, Jiri; Gago, Federico

    2007-10-01

    The different steps of the dehalogenation reaction carried out by LinB on three different substrates have been characterized using a combination of quantum mechanical calculations and molecular dynamics simulations. This has allowed us to obtain information in atomic detail about each step of the reaction mechanism, that is, substrate entrance and achievement of the near-attack conformation, transition state stabilization within the active site, halide stabilization, water molecule activation and subsequent hydrolytic attack on the ester intermediate with formation of alcohol, and finally product release. Importantly, no bias or external forces were applied during the whole procedure so that both intermediates and products were completely free to sample configuration space in order to adapt to the plasticity of the active site and/or search for an exit. Differences in substrate reactivity were found to be correlated with the ease of adopting the near-attack conformation and two different exit pathways were found for product release that do not interfere with substrate entrance. Additional support for the different entry and exit pathways was independently obtained from an examination of the enzyme's normal modes.

  14. An attempt of using soil grain size in calculating the capacity of water unavailable to plants / Próba wykorzystania uziarnienia gleby do obliczania zawartości wody niedostępnej dla roślin

    Brogowski Zygmunt

    2015-03-01

    Full Text Available Celem pracy była próba znalezienia możliwości obliczenia ilości wody niedostępnej dla roślin na podstawie uziarnienia gleb. Frakcje o średnicach <0,02 mm gromadzą od 90,1 do 98,8% całkowitej ilości wody niedostępnej dla roślin, a frakcja iłu koloidalnego (<0,002 mm zatrzymuje od 52,1 do 80,1% tej wody. Gromadzenie wody we frakcjach <0,02 mm znacząco zależy od ich składu mineralogicznego. Obecność we frakcjach illitu, chlorytu oraz kaolinitu powoduje zmniejszenie ilości wody niedostępnej nawet o 40% w stosunku do frakcji zbudowanych ze smektytów, wermikulitów oraz próchnicy. Ze względu na duże zróżnicowanie ilości wody niedostępnej dla roślin w poszczególnych frakcjach granulometrycznych <0,02 mm wynikaj¹ce ze zróżnicowania mineralogicznego tych frakcji nie udało się wyprowadzić współczynników pozwalających na obliczenie ilościowe w glebach wody niedostępnej dla roślin wiązanej w mikroporach <0,2 μm.

  15. Planning by Using Digital Technology in the Reconstruction of Cultural Heritage Sites - a Case Study of Qiong-Lin Settlement in Kinmen Area

    Yang, W. B.; Ye, Y. N.

    2017-08-01

    ICOMOS Florence Declaration in 2014, encourages an in-depth reflection on human values through cultural heritage and landscapes, which emphasizes the importance of historical heritage sites, in order to achieve the application of cultural heritage records through the public participation, sharing new technology platform and facilitation tools for knowledge diffusion, for instance. Nikos adopted digitized intangible cultural heritage within i-Treasures project to create a novel digital platform in 2016. Nowadays, the display platform developed based on geographic information system has been gradually accepted and widely used to distribute cultural heritage information, aiming to combine geography, time, events, issues, trends with the interactive maps to show the context of data changes from the consideration of planarity; for example, Burnaby City in Canada has cooperated with the Columbia University to create a navigation platform for guidance of tangible cultural heritage based on story maps in order to provide public recognition function. In this study, Qiong-Lin Settlement in Kinmen Area was taken as an example to illustrate the developing process of an overall planning framework for reappearing the glory of historic settlements of cultural heritage sites with digital technology, which included tangible and intangible cultural heritage preservation and transmission planning, community participation and digital navigation programs. The digital technology with the GIS-based digital platform can provide more diverse and interesting information while using an intuitive, graphical user story mapping interface. So that tangible cultural heritage can be effectively understood, interpreted and preserved with the value-added methods, and also intangible cultural heritage can be continuously transmitted to establish a complete system of cultural heritage preservation. The main contents include several navigation technologies, such as 3D laser scanning, UAV images

  16. [Pollution characteristics and ecological risk assessment of heavy metals in surface sediments of Qingshan Reservoir in Lin' an City, Zhejiang Province of East China].

    Zhang, Fen; Yang, Chang-Ming; Pan, Rui-Jie

    2013-09-01

    A total of 8 representative surface sediment sampling sites were collected from the Qingshan Reservoir in Lin'an City of Zhejiang Province to investigate the differences in the total concentrations of As, Cr, Cu, Ni, Mn, Pb, and Zn among the sampling sites. The different forms of the heavy metals, i. e., acid soluble, easily reducible, easily oxidizable, and residual, were determined by BCR sequential extraction method, and the pollution degrees and potential ecological risk, of the heavy metals in the surface sediments at different sampling sites of the Reservoir were assessed by using geo-accumulation index (I(geo)) and Hakanson potential ecological risk index. There existed obvious spatial differences in the total concentrations of the heavy metals in the surface sediments of the Reservoir. The sampling sites nearby the estuaries of the tributaries flowing through downtowns and heavy industrial parks to the Reservoir had obviously higher heavy metals concentrations in surface sediments, as compared to the other sampling sites. In the sediments, Mn was mainly in acid extractable form, Cu and Pb were mainly in reducible form, and As was mainly in residual form. The surface sediments at the sampling sites nearby the estuaries of the tributaries flowing through downtowns to the Reservoir had higher proportions of acid extractable and reducibles forms of the heavy metals, which would have definite potential toxic risk to aquatic organisms. Among the 7 heavy metals in the surface sediments, As showed the highest pollution degree, followed by Cu, Ni, Mn, Pb, and Zn, which were at moderate pollution degree, while Cr was at non-pollution degree, with relatively low potential ecological risk. Through the comparison of the sampling sites, it was observed that the surface sediments at the sites nearby the estuaries of Jinxi River and Hengxi River flowing through downtowns and heavy industrial parks to the Reservoir showed obviously higher heavy metals pollution degree and

  17. Caenorhabditis elegans histone deacetylase hda-1 is required for morphogenesis of the vulva and LIN-12/Notch-mediated specification of uterine cell fates.

    Ranawade, Ayush Vasant; Cumbo, Philip; Gupta, Bhagwati P

    2013-08-07

    Chromatin modification genes play crucial roles in development and disease. In Caenorhabditis elegans, the class I histone deacetylase family member hda-1, a component of the nucleosome remodeling and deacetylation complex, has been shown to control cell proliferation. We recovered hda-1 in an RNA interference screen for genes involved in the morphogenesis of the egg-laying system. We found that hda-1 mutants have abnormal vulva morphology and vulval-uterine connections (i.e., no uterine-seam cell). We characterized the vulval defects by using cell fate-specific markers and found that hda-1 is necessary for the specification of all seven vulval cell types. The analysis of the vulval-uterine connection defect revealed that hda-1 is required for the differentiation of the gonadal anchor cell (AC), which in turn induces ventral uterine granddaughters to adopt π fates, leading to the formation of the uterine-seam cell. Consistent with these results, hda-1 is expressed in the vulva and AC. A search for hda-1 target genes revealed that fos-1 (fos proto-oncogene family) acts downstream of hda-1 in vulval cells, whereas egl-43 (evi1 proto-oncogene family) and nhr-67 (tailless homolog, NHR family) mediate hda-1 function in the AC. Furthermore, we showed that AC expression of hda-1 plays a crucial role in the regulation of the lin-12/Notch ligand lag-2 to specify π cell fates. These results demonstrate the pivotal role of hda-1 in the formation of the vulva and the vulval-uterine connection. Given that hda-1 homologs are conserved across the phyla, our findings are likely to provide a better understanding of HDAC1 function in development and disease.

  18. The pedagogical value of a student-run community-based experiential learning project: The Yong Loo Lin School of Medicine Public Health Screening.

    Wee, Liang En; Yeo, Wei Xin; Tay, Clifton M; Lee, Jeannette J M; Koh, Gerald C H

    2010-09-01

    We assessed the pedagogical value of a student-led community-based experiential learning project called the Public Health Screening (PHS) run by medical and nursing students of the National University of Singapore's Yong Loo Lin School of Medicine (NUS YLLSoM). We conducted a cross-sectional study using a self-administered anonymised questionnaire on medical and nursing students who participated in PHS using the Fund for the Improvement of Postsecondary Education (FIPSE) Survey Instrument. Participants also gave an overall score for their learning experience at the PHS. The participation rate was 93.1% (576/619) for medical students and 100% (37/37) for nursing students. All participants gave the PHS learning experience a high rating (median = 8 out of maximum of 10, inter-quartile range, 7 to 9). A majority of participants felt that PHS had helped them to improve across all domains surveyed. For medical students, those in preclinical years and females were independently more likely to feel that PHS had helped them to improve in communication skills, teamwork, ability to identify social issues, taking action, and gaining and applying their knowledge than those in clinical years and males. Improved ability to interact with patients (β=1.64, 95%CI, 1.01-2.27), appreciation of challenges to healthcare faced by Singaporeans from lower income groups (β=0.93, 95%CI, 0.49-1.37), thinking of others (β=0.70, 95%CI, 0.04-1.37) and tolerance of different people (β =0.63, 95%CI, 0.17-1.10) were strongly associated with the overall rating score. PHS was a positive learning experience in a wide range of domains for all students involved. This suggests that student-organised community-based experiential learning projects have potential educational value for both medical and nursing students.

  19. SKR-1, a homolog of Skp1 and a member of the SCFSEL-10 complex, regulates sex-determination and LIN-12/Notch signaling in C. elegans

    Killian, Darrell J.; Harvey, Elizabeth; Johnson, Peter; Otori, Muneyoshi; Mitani, Shohei; Xue, Ding

    2008-01-01

    Sex-determination in C. elegans requires regulation of gene transcription and protein activity and stability. sel-10 encodes a WD40-repeat-containing F-box protein that likely mediates the ubiquitin-mediated degradation of important sex-determination factors. Loss of sel-10 results in a mild masculinization of hermaphrodites, whereas dominant alleles of sel-10, such as sel-10(n1074), cause a more severe masculinization, including a reversal of the life versus death decision in sex-specific neurons. To investigate about how sel-10 regulates sex-determination, we conducted a sel-10(n1074) suppressor screen and isolated a weak loss-of-function allele of skr-1, one of 21 Skp1-related genes in C. elegans. Skp1, Cullin, and F-box proteins, such as SEL-10, are components of the SCF E3 ubiquitin ligase complex. We present genetic evidence that the sel-10(n1074) masculinization phenotype is dependent upon skr-1 and cul-1 activity. Furthermore, we show that the SKR-1(M140I) weak loss-of-function mutation interferes with SKR-1/SEL-10 binding. Unexpectedly, we found that the G567E substitution in SEL-10 caused by the n1074 allele impairs the binding of SEL-10 to SKR-1 and the dimerization of SEL-10, which may be important for SEL-10 function. Our results suggest that SKR-1, CUL-1 and SEL-10 constitute an SCF E3 ligase complex that plays an important role in modulating sex-determination and LIN-12/Notch signaling in C. elegans. PMID:18718460

  20. PLANNING BY USING DIGITAL TECHNOLOGY IN THE RECONSTRUCTION OF CULTURAL HERITAGE SITES – A CASE STUDY OF QIONG-LIN SETTLEMENT IN KINMEN AREA

    W. B. Yang

    2017-08-01

    Full Text Available ICOMOS Florence Declaration in 2014, encourages an in-depth reflection on human values through cultural heritage and landscapes, which emphasizes the importance of historical heritage sites, in order to achieve the application of cultural heritage records through the public participation, sharing new technology platform and facilitation tools for knowledge diffusion, for instance. Nikos adopted digitized intangible cultural heritage within i-Treasures project to create a novel digital platform in 2016. Nowadays, the display platform developed based on geographic information system has been gradually accepted and widely used to distribute cultural heritage information, aiming to combine geography, time, events, issues, trends with the interactive maps to show the context of data changes from the consideration of planarity; for example, Burnaby City in Canada has cooperated with the Columbia University to create a navigation platform for guidance of tangible cultural heritage based on story maps in order to provide public recognition function. In this study, Qiong-Lin Settlement in Kinmen Area was taken as an example to illustrate the developing process of an overall planning framework for reappearing the glory of historic settlements of cultural heritage sites with digital technology, which included tangible and intangible cultural heritage preservation and transmission planning, community participation and digital navigation programs. The digital technology with the GIS-based digital platform can provide more diverse and interesting information while using an intuitive, graphical user story mapping interface. So that tangible cultural heritage can be effectively understood, interpreted and preserved with the value-added methods, and also intangible cultural heritage can be continuously transmitted to establish a complete system of cultural heritage preservation. The main contents include several navigation technologies, such as 3D laser scanning

  1. "O Romancista e o Engenho: José Lins do Rego e o regionalismo nordestino dos anos 1920 e 1930", de Mariana Ghaguri "O Romancista e o Engenho: José Lins do Rego e o regionalismo nordestino dos anos 1920 e 1930", by Mariana Chaguri

    Mário Augusto Medeiros da Silva

    2013-04-01

    Full Text Available Trata-se das relações entre a formalização estética do Ciclo da Cana de Açúcar e o processo social do Regionalismo Nordestino. Analisa a trajetória social e produção literária de José Lins do Rego, buscando deslindar as formas de realização social do autor, nos circuitos intelectuais e políticos de que participou (Pernambuco e Rio de Janeiro, notadamente e as condições sociais de produção de sua obra (editoras em que a mesma é publicada, recepção entre a crítica de época etc.. Em vista das disputas travadas com os Modernistas paulistas de 1922, sua interpenetração com a crise política dos anos 1930 e com as formulações de Gilberto Freyre acerca das ideias de Região e Nação, Chaguri sugere a análise do Regionalismo Nordestino como parte de um projeto estético e político, cujas intenções e consequências merecem ser sociologicamente examinadas.The book deals with the relations between the aesthetics formalization of the Sugarcane Cycle and the social process of the Brazilian Northeastern regionalism. It analyzes the social trajectory and literary work of José Lins do Rego, seeking to disclose this author's ways of social fulfillment in the intellectual and political circles he participated (especially in Pernambuco and Rio de Janeiro as well as the social conditions of production of his work (his publishers, critiques etc.. Considering his disputes with members of the 1922 modernist movement, intertwined with the political crisis of the 1930s and the formulations of Gilberto Freyre's notions about Region and Nation, Chaguri suggests the analysis of Northeastern Regionalism while part of an aesthetic and political project whose intentions and consequences deserve to be sociologically examined.

  2. É tempo de pipa: a representação da infância em Cidade de Deus, de Paulo Lins, e Lembrancinha do Adeus, de Júlio Ludemir

    Anderson Luís Nunes da Mata

    2009-01-01

    Full Text Available Traditionally understood as an age of innocence and learning, childhood has been shown indifferent colors in the so called "slum" narratives. Thus, poor children, who live in the urban peripheral areas, are represented in fiction as a counterface for such traditional notion of childhood. Lembrancinha do Adeus, by Julio Ludemir, and Cidade de Deus, by Paulo Lins, are both novels built upon characters who maintain only remains of childhood, which indicates both a new sociability for such children and deeper social changes.

  3. Linéarité et développement d'un système technique Linearity and Development of a Technical System

    Dautray R.

    2006-11-01

    Full Text Available Il est examiné comment la structurede la modélisation d'un phénomène ou d'un processus ou du fonctionnement d'un appareil joue un rôle déterminant dans le plan des expériences destinées à obtenir les connaissances nécessaires à son étude et à sa réalisation. Dans le cas d'une structure linéaire , il est montré, sur l'exemple de l'énergie nucléaire, que ces expériences peuvent être menées sur des appareils distincts, les résultats de l'une servant à déterminer les entrées de l'autre. Ce découplagepermet de mener en parallèle un très grand programme d'expériences, et donc de construire relativement rapidement ces nouvelles technologies. C'est en effet le cas de l'énergie nucléaire de fission : - Le phénomène de fission a été découvert en 1938. - La démonstration de la faisabilité physique de la réaction en chaîne a été démontrée en 1942. - Les premiers réacteurs nucléaires de puissance ont fonctionné à Hanford en 1945. - Et dès les années cinquante, des réacteurs nucléaires actionnaient des sous-marins et des prototypes de chaudières nucléaires pour centrales (Shippingport et Calder Hall. This article examines how the structureof the modeling of a phenomenon or process or the operating of a piece of equipment plays a determinant role in the planning of experiments for the purpose of obtaining the understanding required to analyze it and create it. For a linear structure , the example of nuclear energy is taken to show that these experiments can be performed with distinct pieces of equipment, with the results of one being used to determine the input for the other. This uncouplingenables a very widespread experimental project to be carried out in parallel, so that these new technologies can be built up relatively quickly. This is effectively true for nuclear energy from fission. - The phenomenon of fission was discovered in 1938. - The physical feasibility of the chain reaction was demonstrated

  4. WYSTĘPOWANIE ROŚLIN INWAZYJNYCH W OBRĘBIE BUDOWLI I POWIERZCHNI UTWARDZONYCH W DOLINACH RZECZNYCH KARPAT I KOTLINY SANDOMIERSKIEJ

    Dominik WRÓBEL

    Full Text Available Badania terenowe, prowadzone w latach 2010-2016, w dolinach rzecznych polskiej części Karpat oraz w Kotlinie Sandomierskiej i w przylegającym do niej odcinku doliny Wisły, miały za zadanie uzupełnić, wiedzę o występowaniu inwazyjnych gatunków roślin (inwaderów w najsilniej przekształconych dolinach rzecznych, a w szczególności określić typy zabudowy dolin rzecznych, sprzyjające rozprzestrzenianiu się tych gatunków. Przeanalizowano 118 transektów zlokalizowanych zarówno w regionach górskich, podgórskich i nizinnych, w odcinkach uregulowanych jak i nieuregulowanych dolin rzecznych, cieków o różnej wielkości. Wyodrębniono główne typy/kategorie zabudowy, łączące w sobie: obiekty hydrotechniczne i przeciwpowodziowe, w tym obwałowania, umocnienia brzegowe i ostrogi korytowe (I, mieszkalną i usługową zabudowę śródmiejską (II, drogowe i kolejowe linie komunikacyjne, w tym mosty (III, wyrobiska górnicze, zabudowę produkcyjną, wydobywczą, magazynową i towarzyszącą (IV, zabudowę rozproszoną, ogródki działkowe (V oraz odrębne place, parkingi i składowiska (VI. Na częściach transektów, obejmujących różne formy zabudowy, najczęściej zanotowano występowanie Solidago gigantea / S. canadensis (46, Impatiens glandulifera (30, Echinocystis lobata (22, Robinia pseudoacacia (17, Helianthus tuberosus (15 i Impatiens parviflora (15. Największa liczba stanowisk gatunków inwazyjnych w relacji do wszystkich ich stwierdzeń została zanotowana na różnego rodzaju budowlach hydrotechnicznych, w tym na umocnieniach brzegowych różnego typu. Obserwacje prowadzone w zakresie wpływu inwestycji regulacyjnych na szatę roślinną wskazują, że nie ma istotnych różnic co do zastosowanych sposobów zabudowy umocnieniowej brzegów, które można byłoby uznać za bardziej przyjazne środowisku. W każdym przypadku następuje pozostawianie odkrytego podłoża i promowanie wkraczania inwaderów.

  5. Saúde mental no Sistema Único de Saúde: mudança do modelo de atenção na região de Lins-SP Mental health in Sistema Único de Saúde: changing the care model in the region of Lins - SP

    Carlos Cesar Escudeiro

    2009-03-01

    Full Text Available Omunicípio de Linspassou portransformações significativas na atenção em Saúde Mental, evoluindo deum modelo de referência hospitalar para um modelo de base territorial e comunitária. Este trabalho tem como objetivo realizar uma retrospectiva históricadas mudanças ocorridas, descrevendoas ações de assistência, promoção, prevenção e reabilitação psicossocial, através da implantação deserviços substitutivos integrados à atenção básica, apontando as soluções capazes de efetivar os princípios do Sistema Único de Saúde (SUS. Priorizou-se a implantação dos Centros de atenção Psicossocial que são dispositivos estratégicos para favorecer a inserção social. A Gestão Municipal realizou significativos investimentos técnicos e financeiros que possibilitaram a consolidação da Política Nacional de Saúde Mental, ampliando as articulações intersetoriais.The municipality of Lins, in the state of São Paulo, has undergone significant transformations in Mental Health Care, evolving from a hospital reference model to a territorial and community-based model. This work aims to carry out a historical retrospective of the changes that have occurred, describing the actions of psychosocial assistance, promotion, prevention and rehabilitation through the implementation of substitutive services integrated into primary care, pointing to the solutions that can fulfill the principles of Sistema Único de Saúde (SUS - National Health System. The priority was the implementation of Centros de Atenção Psicossocial (Psychosocial Care Centers, which are strategic devices to favor social insertion. The Municipal Management has made significant technical and financial investments that have enabled the consolidation of the National Mental Health Policy, extending inter-sector articulations.

  6. Etude de la stabilité globale de l’équilibre endémique des modèles multi groupes SIR avec une incidence non linéaire.

    BENCHAIB, NESRINE

    2014-01-01

    Dans ce mémoire, on présente le nombre de reproduction de base pour un modèle épidémique multigroupe avec une incidence non linéaire. Ensuite, on établie la dynamique globale est entièrement déterminée par le nombre de reproduction de base R0. On montre que le nombre de reproduction de base R0 est un paramètre global de seuil dans le sens que si il est inférieur ou égale à 1, l’équilibre sans maladie est globalement stable et la maladie s’éteint, alors que si il est supérieur à 1, il est u...

  7. Caractérisation microstructurale et mécanique d’un composite cimentaire renforcé par des fibres de lin Characterizations mechanical and microstructural of flax fibre cement composite reinforced

    Boutouil M.

    2012-09-01

    Full Text Available Dans la perspective de valorisation des fibres de lin dans les matériaux de construction, la présente étude s’intéresse à la caractérisation microstructurale et mécanique d’un composite cimentaire renforcé par des fibres de lin. Les analyses microstructurales au MEB ont été menées pour évaluer l’homogénéité de la distribution des fibres, la qualité de l’interaction fibre/matrice et l’influence de leur présence sur les défauts microstructuraux. Le comportement mécanique en flexion du mortier renforcé par les fibres de lin est étudié en fonction de la longueur et la teneur en fibres. Les résultats indiquent une bonne adhésion entre les fibres et la matrice à l’état frais. Mais les fibres étant hydrophiles, elles gonflent pendant la prise du ciment et le retrait lors du séchage engendre alors des déchaussements. Les résultats de caractérisation mécanique sont encourageants. Tout d’abord, la fissuration du mortier due au retrait au jeune âge est fortement réduite du fait de la présence des fibres. Ensuite, la rupture brutale de la matrice en monolithe laisse place à un comportement quasi-ductile quand la teneur ou la longueur de fibre augmente. Ce changement de comportement, analysé en termes d’indice de ténacité, illustre la capacité remarquable des fibres de lin à renforcer les matrices cimentaires du fait de leurs bonnes propriétés mécaniques. With the purpose of the flax fibre valuing in construction materials, this study focuses on the characterizations mechanical and microstructural of flax fibre cement composite reinforced. The mechanical strength was studied as the function of fibre volume ratio and length. Meanwhile, the microstructural analysis investigated the homogeneity of fibre scattering, the interaction fibre/cement matrix and the influence of flax fibres on the defects microstructures. The results show the interesting mechanical properties of flax fibre in comparison with

  8. Heterodimerization with the β1 subunit directs the α2 subunit of nitric oxide-sensitive guanylyl cyclase to calcium-insensitive cell-cell contacts in HEK293 cells: Interaction with Lin7a.

    Hochheiser, Julia; Haase, Tobias; Busker, Mareike; Sömmer, Anne; Kreienkamp, Hans-Jürgen; Behrends, Sönke

    2016-12-15

    Nitric oxide-sensitive guanylyl cyclase is a heterodimeric enzyme consisting of an α and a β subunit. Two different α subunits (α 1 and α 2 ) give rise to two heterodimeric enzymes α 1 /β 1 and α 2 /β 1 . Both coexist in a wide range of tissues including blood vessels and the lung, but expression of the α 2 /β 1 form is generally much lower and approaches levels similar to the α 1 /β 1 form in the brain only. In the present paper, we show that the α 2 /β 1 form interacts with Lin7a in mouse brain synaptosomes based on co-precipitation analysis. In HEK293 cells, we found that the overexpressed α 2 /β 1 form, but not the α 1 /β 1 form is directed to calcium-insensitive cell-cell contacts. The isolated PDZ binding motif of an amino-terminally truncated α 2 subunit was sufficient for cell-cell contact localization. For the full length α 2 subunit with the PDZ binding motif this was only the case in the heterodimer configuration with the β 1 subunit, but not as isolated α 2 subunit. We conclude that the PDZ binding motif of the α 2 subunit is only accessible in the heterodimer conformation of the mature nitric oxide-sensitive enzyme. Interaction with Lin7a, a small scaffold protein important for synaptic function and cell polarity, can direct this complex to nectin based cell-cell contacts via MPP3 in HEK293 cells. We conclude that heterodimerization is a prerequisite for further protein-protein interactions that direct the α 2 /β 1 form to strategic sites of the cell membrane with adjacent neighbouring cells. Drugs increasing the nitric oxide-sensitivity of this specific form may be particularly effective. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. A Formalism for the Consistent Description of Non-Linear Elasticity of Anisotropic Media Formalisme pour une description cohérente de l'élasticité non linéaire des milieux anisotropes

    Helbig K.

    2006-12-01

    deviation can be expressed by the relative change of the eigenstiffnesses and by the variation in the direction of the eigenstrains (expressed as vectors in six-dimensional strain space. The suggested procedure is applied to the two materials discussed by Rasolofosaon and Yin (1996. The results allow a heuristic evaluation of the meaning of the reference strain , the square root of the ratio of the norms of the fourth-rank and sixth-rank stiffness tensors. It is stressed that this is not a new theory of non-linearity, but only a different way of viewing the existing theory and results. La propagation des ondes élastiques est généralement traitée sous quatre hypothèses : - le milieu est isotrope, - le milieu est homogène, - il y a une relation biunivoque entre la tension et la déformation, - les tensions sont reliées d'une façon linéaire aux déformations (et de manière équivalente, les déformations sont reliées d'une façon linéaire aux tensions. En général au moins une de ces hypothèses - et souvent toutes - n'est pas vérifiée dans les milieux réels. Une description théorique valide de la propagation des ondes dans les milieux réels dépend ainsi de la description à la fois qualitative et quantitative de l'hétérogénéité, de l'anisotropie et de la non-linéarité : soit on doit supposer (ou montrer que l'écart par rapport à l'hypothèse de départ peut être - pour le problème considéré - négligé, soit on doit développer une description théorique, valide même en présence de ces écarts. Alors que l'effet d'un seul écart par rapport à un état idéal est relativement bien connu, les difficultés surviennent quand on veut combiner plusieurs de ces écarts. Les propriétés élastiques non linéaires d'échantillons de roche anisotropes (tricliniques ont été étudiées, par P. Rasolofosaon et H. Yin au 6e IWSA à Trondheim (Rasolofosaon et Yin, 1996. L'élasticité anisotrope non linéaire est importante seulement pour les amplitudes

  10. Journal of Biosciences | Indian Academy of Sciences

    Author Affiliations. Guanshui Chen Daren Pan1 Yifei Zhou Sheng Lin2 Xiangde Ke. College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, the People's Republic of China; College of Crop Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, the People's Republic ...

  11. Étude numérique du couplage thermohydromécanique dans les roches. Influence des termes de couplage non linéaires pour un matériau isotrope linéaire Numerical Analysis of a Thermohydromechanical Coupling in Rocks. Influence of Nonlinear Coupling Terms on a Linear Isotropic Material

    Henry J. P.

    2006-11-01

    Full Text Available Nous présentons dans ce travail une étude numérique basée sur la méthode des éléments finis, du comportement thermoporoélastique de certaines roches. Les trois effets de couplage : déformabilité de la roche, pression interstitielle et température sont pris en compte simultanément dans la résolution numérique. Une application simple sur un puits pétrolier en conditions axisymétriques est finalement présentée afin de dégager en particulier l'influence du terme de couplage convectif non linéaire, obtenu dans l'équation de diffusivité thermique, sur l'évolution de la température et de la pression interstitielle autour du forage. This article describes a finite-element method for solving the problem of nonlinear coupling between interstitial pressure and temperature during stress on a poroelastic rock. Such coupling phenomena occur during massive injection of cold water into a petroleum borehole for example. The implementation of such a numerical solution, used here with the assumption of small deformations, first requires a review of the behavior law of the material (Eq. 2. 2 and of the equations for hydraulic diffusivity (Eq. 2. 3 and thermal diffusivity (Eq. 2. 4. This last equation (2. 4 is the one containing the nonlinear coupling terms in Grad P Grad P and Grad T. Grad P. During simulation of flow at a high flow rate, these products can no longer be neglected as shown by the results in Fig. 2. The variational formulation of the problem is then determined in relation to the three equations for equilibrium, thermal diffusivity and hydraulic diffusivity. After geometric and temporal discretizations, this formulation leads to a finite-element calculating scheme resulting in the simultaneous solving of all three equations. This solution, based on the inversion of the system of equations (2. 15, requires the updating of the rigidity matrix at each time step to take nonlinear coupling into consideration. Calculations with an

  12. A model for the Lin-Shu type density-wave structure of our Galaxy: Line-of-sight and transverse-longitudinal velocities of 242 optically visible open clusters

    Griv, E.; Jiang, I.-G.

    2015-02-01

    In this paper, the fourth in a series, we examine again one of the implications of the Lin-Shu density-wave theory, specifically, the noncircular systematic motion of the Galactic objects. Our previous investigation is extended by analyzing simultaneously both the line-of-sight and transversal velocities of a sample of open clusters for which velocities, distances and ages are available. The ordinary equations of the Oort-Lindblad theory of galactic differential rotation are used. The minor effects caused by the two-dimensional tightly-wound density waves are also taken into account. The published data of 242 currently known optically visible clusters having distances rsight and transversal along the Galactic longitude velocities are nearly equal. We argue that the resemblance of these Galactic wave structures is so remarkable that no doubt is felt as to the theory's truth with respect to these data. The results obtained allow us to conclude that several low-m trailing density-wave patterns with different number of spiral arms m (say, m=1, 2, 3, and 4), pitch angles (about 5o, 8o, 11o, and 14o, respectively) and amplitudes of the perturbed gravitational potential may coexist in the Galaxy. The latter suggests the asymmetric multiarm, not well-organized (``flocculent'') spiral structure of the system. In memory of Professors Alexei M. Fridman (1940-2010) and Chi Yuan (1937-2008)

  13. Structural properties of small Lin (n = 5-8) atomic clusters via ab initio random structure searching: A look into the role of different implementations of long-range dispersion corrections

    Putungan, Darwin Barayang; Lin, Shi-Hsin

    2018-01-01

    In this work, we looked into the lowest energy structures of small lithium clusters (Lin, n = 5, 6, 7, 8) utilizing conventional PBE exchange-correlation functional, PBE with D2 dispersion correction and PBE with Tkatchenko and Scheffler (TS) dispersion correction, and searched using ab initio random structure searching. Results show that in general, dispersion-corrected PBE obtained similar lowest minima structures as those obtained via conventional PBE regardless of the type of implementation, although both D2 and TS found several high-energy isomers that conventional PBE did not arrive at, with TS in general giving more structures per energy range that could be attributed to its environment-dependent implementation. Moreover, D2 and TS dispersion corrections found a lowest energy geometry for Li8 cluster that is in agreement with the structure obtained via the typical benchmarking method diffusion Monte Carlo in a recent work. It is thus suggested that for much larger lithium clusters, utilization of dispersion correction could be of help in searching for lowest energy minima that is in close agreement with that of diffusion Monte Carlo results, but computationally inexpensive.

  14. Artificial Intelligence Learning Semantics via External Resources for Classifying Diagnosis Codes in Discharge Notes.

    Lin, Chin; Hsu, Chia-Jung; Lou, Yu-Sheng; Yeh, Shih-Jen; Lee, Chia-Cheng; Su, Sui-Lung; Chen, Hsiang-Cheng

    2017-11-06

    extracted enough concepts to predict the diagnosis codes. Word embedding combined with a CNN showed outstanding performance compared with traditional methods, needing very little data preprocessing. This shows that future studies will not be limited by incomplete dictionaries. A large amount of unstructured information from free-text medical writing will be extracted by automated approaches in the future, and we believe that the health care field is about to enter the age of big data. ©Chin Lin, Chia-Jung Hsu, Yu-Sheng Lou, Shih-Jen Yeh, Chia-Cheng Lee, Sui-Lung Su, Hsiang-Cheng Chen. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 06.11.2017.

  15. Cartographie des linéaments géologiques en domaine aride par extraction semi-automatique à partir d’images satellitaires: Exemple à la région d’El Kseïbat (Sahara algérien

    Hammad, N.

    2016-06-01

    Full Text Available Geologists in charge of a detailed lineament mapping in arid and desert area, face the extent of the land and the abundance of eolian deposits. This study presents a semi-automatic approach of extraction of lineament, different from other methods, such as the automatic extraction and manual extraction, by being both fast and objective. It consists of a series of digital processing (textural and spatial filtering, binarization by thresholding and mathematic morphology ... etc. applied to a Landsat 7 ETM+scene. This semi-automatic approach has produced a detailed map of lineaments, while taking account of tectonic directions recognized in the region. It helps mitigate the effect of dune deposits meet the specifications of arid environment. The visual validation of these linear structures, by geoscientists and field data, allowed the identification of the majority of structural lineaments or at least those tried geological.[fr] Les géologues en charge d’une cartographie des linéaments détaillée en domaine aride et désertique, font face à l’étendue des terrains et la présence abondante de dépôts éoliens. La présente étude présente une approche semi-automatique différente des autres méthodes d’extraction des linéaments, à savoir l’extraction automatique et l’extraction manuelle par le fait d’être à la fois rapide et objective. Elle consiste en une succession de traitements numériques (filtrage textural et spatial, binarisation par seuillage et morphologie mathématique…etc. appliqués sur une scène LANDSAT-7 ETM+. Cette approche semi-automatique a permis d’obtenir une carte détaillée des linéaments, tout en tenant compte des directions tectoniques reconnues dans la région. Elle permet d’atténuer l’effet des dépôts dunaires répondant aux spécifications du contexte aride. La validation visuelle de ces structures linéaires, effectuée sur terrain et sur la base de la carte géologique et des données g

  16. Alimentation animale et organisation des filières : une comparaison pois protéagineux-lin oléagineux pour comprendre les facteurs freinant ou favorisant les cultures de diversification

    Charrier François

    2013-07-01

    Full Text Available Le processus d’intensification des élevages, entamé dans les années 1970, s’est accompagné d’un développement croissant du recours aux aliments dits « composés », fabriqués à partir de différentes matières premières pour la plupart d’origine végétale. Les pratiques de la formulation des fabricants d’aliments composés, fondées sur une très forte substituabilité des matières premières, génèrent une concurrence très forte entre ces commodités. Dans un tel contexte de marché, la valorisation de certaines espèces repose sur des mécanismes permettant de contourner ou de s’affranchir de cette concurrence, mais dont l’efficacité reste fortement dépendante de l’organisation des acteurs au sein des filières. À partir de la comparaison des filières pois et lin, nous montrons ainsi qu’au-delà de la reconnaissance de propriétés nutritionnelles spécifiques pouvant valoriser différemment certaines espèces, la coordination des acteurs le long d’une filière est déterminante dans la diffusion des incitations économiques et informationnelles nécessaires à une orientation des agriculteurs en faveur d’espèces de diversification d’intérêt agro-écologique.

  17. Internet Journal of Medical Update - EJOURNAL - Vol 3, No 2 (2008)

    Lateralization pattern in patients with Schizophrenia and Depression. B Bhushan, A Prakash, R Gupta. http://dx.doi.org/10.4314/ijmu.v3i2.39836 · Gender Determination using Fingertip Features. J-F Wang, C-L Lin, Y-H Chang, ML Nagurka, C-W Yen, C Yeh. http://dx.doi.org/10.4314/ijmu.v3i2.39838 · Effects of smoking on ...

  18. Radiosensitivity study in rice (Oriza Sativa Lin.)

    Gonzalez, M.; Santana, N.; Diaz, R.

    1987-01-01

    Four rice varieties (J-104, Amistad-82, 6066 and IR-1529) were irradiated at doses of 10,15,20,25,30,35,40,45,50 and 55 Krad of gamma rays so as to determine radiosensitivity curves for each of the varieties for the following factors; seed germination percentage; survival percentage; height of the plant; length of roots. It was determined that IR-1529 variety is the one with the highest sensitivity and that radiations over 35 Krad should not be used for none of the varieties above mentioned

  19. ANALISIS STATUS LINGKUNGAN IRIGASI TUKAD YEH EMPAS DAN SUBAK MUNDUK LENGGUNG DI DUSUN BOLANGAN DESA BABAHAN KECAMATAN PENEBEL KABUPATEN TABANAN

    I NYOMAN SUMANTRA

    2015-06-01

    Full Text Available Livestock is one business that was developed in order to meet basic human needs of the flesh. In its development, livestock will produce waste harmful to the environment. The purpose of this study to determine the characteristics and environmental management of farms, the quality and quantity of waste and its impact on the environment and to know the public perception and labor to the impact of livestock on the environment, economy and social life of communities around the farm and ranch labor. Characteristics and environmental management by the entrepreneur obtained by distributing questionnaires livestock determination of the sample by random sampling, samples for the determination of the quality and quantity of livestock waste with purposive sampling. Samples were taken at three points of different sewage farms and compared with the Minister of State for the Environment No. 11 of 2009 and four points on the body of water and then compared with the Bali gubernatorial No.8 of 2007. Samples were analyzed in situ and laboratory. To know the public perception and labor obtained by distributing questionnaires determination of samples with random sampling. Environmental management by the entrepreneur is less cattle. quality of wastewater from hog farms shows the parameters of TSS (1082.57 mg / 1. quantity of wastewater from pig farms outlet (Qo2 0.004 m3/dt, TSS pollutant load on a pig farm (4330.68 mg / dt. Parameter that exceeds the quality standard on water bodies (TSS, BOD5, COD. Public perception and labor to the impact of farm businesses is positive (good.

  20. Comportement mécanique des tuyaux. Influence de la traction, de la pression et du poids linéique. Application aux risers Mechanical Behavior of Pipes and Risers. Influence of Tension, Pressure and Weight

    Sparks C.

    2006-11-01

    Full Text Available L'influence de la traction, de la pression et du poids linéique sur le comportement d'un tuyau (ou d'un riser a déjà été traitée dans de nombreux articles. Malgré cela, elle est fréquemment mal comprise, ce qui a parfois de; conséquences sérieuses. Par souci de clarté, l'approche de cet article est délibérément très élémentaire. Les problèmes principaux de la flexion, du flambage, de l'allongement et de la contrainte limite, qui sont souvent traités dans des articles différents, sont ici étudiés ensemble d'une façon homogène. On présente des interprétation: physiques, faciles à visualiser, des deux concepts de tension effective et de contrainte effective, dont l'utilisation est très répandue, ainsi que leur rapport avec des notions analogues dans d'autres domaines de l'art de l'ingénieur. La puissance de ces deux concepts est démontrée à la fin de l'article où ils sont utilisés pour résoudre huit problèmes divers. The influence of tension, pressure, and weight on different aspects of pipe and riser behavior has already been the subject of many articles (see references. In spite of this it has frequently been misunderstood, sometimes with serious consequences. The object of this payer is to explain the subject clearly and the approach is therefore deliberately very elementary. The principal problems of bending, buckling, yielding and strains, usually treated in separated papers, are here treated homogeneously. The widely used concepts of effective tension and effective stress are given interpretations, easy to visualise, which are related to analogous concepts in other engineering fields. Finally, eight diverse particular examples of the influence of tension, pressure and weight on pipe and riser behavior, are discussed.

  1. A Real-Time Implementable NMPC Output Feedback for a Diesel Engine Air Path Commande prédictive non linéaire avec retour de sortie implémentable en temps-réel pour un circuit d’air d’un moteur Diesel

    Murilo A.

    2011-09-01

    Full Text Available In this paper, an experimental validation of a parameterized Nonlinear Model Predictive Control (NMPC scheme with a Moving Horizon Observer (MHO is presented for a Diesel engine air path. The control design based on the parameterized approach leads to a low dimensional optimization problem which makes the proposed controller real-time implementable. An attractive feature of this control strategy lies in its compatibility with more elaborated and fully nonlinear models since it uses the model as a black box predictor. Dans cet article, une validation expérimentale d’un schéma de commande prédictive non linéaire (CPNL paramétrique avec un observateur à horizon glissant a été proposé pour le circuit d’air d’un moteur Diesel. La stratégie de commande basée sur l’approche paramétrique à faible dimension s’est montrée implémentable en temps réel et peut être utilisée aussi en tant qu’une solution du type boîte noire indépendamment de la structure du modèle non linéaire.

  2. One-step hysteroscopic myomectomy using Lin dissecting loop and Lin myoma graspers

    Bao-Liang Lin

    2012-11-01

    Conclusion: Using our technique and instruments, it is possible to remove a myoma in a single procedure safely and effectively. This surgical method can also preserve more endometrium, cause less injury to the muscle layer, and prevent fluid complications.

  3. Modulation of epithelial sodium channel in human alveolar epithelial ...

    Modulation of epithelial sodium channel in human alveolar epithelial cells by lipoxin A4 through AhR-cAMP-dependent pathway. Bi-Huan Cheng1,2, Li-Wei Pan2, Sheng-Rong Zhang3, Bin-Yu Ying2, Ben-Ji. Wang2, Guo-Liang Lin2 and Shi-Fang Ding1*. 1Department of Critical Care Medicine, Qilu Hospital of Shandong ...

  4. Color in packaging design : Case: ZheJiang JinSheng packaging Co,Ltd

    Hu, Cuicui

    2010-01-01

    Color occupies an important position in packaging design, with the improvement of living standard, the higher requirement of color design in packaging. The aim of this thesis was to discuss key issues concerning aesthetics of packaging design. Topics will include an overview of the packaging design, the influence factor of packaging design, and introduce the aesthetics from packaging aspect. This thesis will also identify common problems of the production process, and list the phases of ho...

  5. Patrimoine linguistique au Kenya : Genèse et évolution du Sheng

    Pof

    On ignore les exactes circonstances qui auraient contribué à l'émergence de cet idiome en. 2 Selon le ... guerre mondiale qui prit fin en 1945 beaucoup de jeunes Kenyans se ruent dans la ville de. Nairobi en quête de ..... cet état de choses ?

  6. Ancrage des vortex dans les supraconducteurs Description phénoménologique de la réponse linéaire d'un de vortex ancré

    Lütke-Entrup, N.; Plaçais, B.; Mathieu, P.; Simon, Y.

    Vortices pinning in supraconductors In this article we report on the investigation of the dynamics of vortices based on the high frequency linear response. We present a serie of measurements of the complex penetration depth in the mixed state in a variety of samples, including conventional materials (Nb, V, PbIn), the non-conventional heavy fermion UPt3, and the high-T_c cuprate YBaCuO. We have explored a large frequency range (1 kHz 10 MHz) so as to cover the cross-over from the quasi-static response, which is dominated by elastic interactions between vortices and sample defects, to the high-frequency regime, which is governed by viscous damping due to vortex friction against the host crystal. For a quantitative description of the frequency spectrum we start from a phenomenological theory which makes a rigorous distinction between vortex lines, along a vortex field omega, and magnetic field lines B. It predicts a second electrodynamical mode, which is linked to the vortex line tension and has a rather short range. We show that, in the limit of small vortex oscillations, amplitude and phase of the linear response are governed by an additional boundary condition for the vortex lattice at the sample surface ; it takes the form of a slipping condition with a characteristic length that depends on the surface roughness. The frequency spectrum deduced from this mechanism is clearly different from the Campbell spectrum, which is the common signature of all bulk pinning mechanisms. Our results on samples of PbIn, Nb, V, and YBaCuO entirely confirm our model, including some non-intuitive size effects which appear at low frequency when the sample becomes transparent to the flux flow mode. However, our measurements in the B and C phases of UPt3 reveal and important contribution of the bulk to the vortex pinning. Ce travail porte sur l'étude de l'ancrage des vortex par la réponse linéaire haute fréquence. Nous présentons une série de mesures de la profondeur de p

  7. Nonlinear EGR and VGT Control with Integral Action for Diesel Engines Régulation de Recirculation des Gaz d’Echappement (RGE et de Turbine à Géométrie Variable (TGV non linéaire avec action intégrée pour moteurs Diesel

    Wahlström J.

    2011-10-01

    Full Text Available A nonlinear multivariable control design with integral action is proposed and investigated for control of Exhaust Gas Recirculation (EGR and Variable Geometry Turbine (VGT in heavy duty Diesel engines. The main control goal is to regulate oxygen/fuel ratio and intake manifold EGR-fraction, and they are specified in an outer loop. These are chosen as main performance variables since they are strongly coupled to the emissions. An existing nonlinear control design based on feedback linearization is extended with integral action. In particular, the control design method utilizes a control Lyapunov function, inverse optimal control, and a nonlinear input transformation. Comparisons between different control structures are performed in simulations showing the following four points. Firstly, integral action is necessary to handle model errors so that the controller can track the performance variables specified in the outer loop. Secondly, the proposed control design handles the nonlinear effects in the Diesel engine that results in less control errors compared to a control structure with PID controllers. Thirdly, it is important to use the input transformation and it is sufficient to use a control structure with PID controllers and input transformation to handle the nonlinear effects. Fourthly, the proposed control design is sensitive to model errors in the input transformation while a control structure with PID controllers and input transformation handles these model errors. Une conception de régulation non linéaire à variables multiples avec action intégrée est proposée et étudiée pour une régulation de la Recirculation des Gaz d’Echappement (RGE et une Turbine à Géométrie Variable (TGV au sein de moteurs Diesel à usage industriel. L’objectif principal de la régulation consiste à réguler le rapport oxygène / carburant et la fraction de RGE de tubulure d’admission, qui sont spécifiés au sein d’une boucle extérieure. Ceux

  8. Méthode intégro-variationnelle appliquée aux probèmes intérieur et extérieur avec surface libre de l'hydrodynamique linéaire Integro-Variational Method Applied to Indoor and Outdoor Problems with a Free Surface of Linear Hydrodinamics

    Berhault C.

    2006-11-01

    Full Text Available Le but de cet article est de montrer que l'on peut appliquer une rintégro-variationnelle pour résoudre les problèmes intérieur (comportementliquide en milieu confiné et extérieur (diffraction-radiation de l'hydrodynamique linéaire. Une comparaison des résultats obtenus pour le problème intérieur dans Q les méthodes classiques : équation intégrale (singularités et formulation rationnelle (éléments finis, montre les avantages de cette méthode. The aim of this article is to show that an integro-variational method can be applied for solving interior (behavior of a liquid in a confined environment and exterior (diffraction-radiation problems of linear hydrodynamics. A comparison of the results obtained for the interior problem in IR2 with conventional methods, i.e. intégral équation (singularities and variational formulation (finite elements, shows the advantages of this method.

  9. A Fully Analytical Solution of the Wellbore Stability Problem under Undrained Conditions Using a Linearised Cam-Clay Model Solution analytique au problème de stabilité de puits en conditions non drainées utilisant un modèle de Cam-Clay linéarisé

    Charlez P. A.

    2006-12-01

    Full Text Available This paper presents a linearised version of the Cam-Clay model fully integrated in the scope of the general theory of poroplasticity. The constitutive law which is developed in the scope of the effective plastic stress concept, only contains two plastic parameters (hardening modulus and slope of the critical state line. To be validated, the model is integrated over homogeneous stress paths (hydrostatic, drained triaxial and undrained triaxal then compared with experimental data issued from conventional laboratory triaxial tests. In the second part, a simplified version of the model is applied to the wellbore boundary problem (vertical well in an axisymmetric horizontal stress field and under undrained conditions. Given the linearity of the constitutive law and the a priori knowledge of the shape of the plastic region, the solution (stress, strain and pore pressure is fully analytical. The solution shows that for an overconsolidated material (overconsolidation degree less than 2 the hoop stress is strongly relaxed in the plastic zone. The higher the compressibility of the saturating fluid, the larger the relaxation of the hoop stress. In terms of stability, the more compressible the fluid saturating the porous medium is, the more stable the well will be. Finally the larger the overconsolidation ratio is, the less stable the well will be. Cet article présente une version linéarisée du modèle de Cam-Clay intégré dans le cadre général de la théorie de la poroplasticité isotherme. La loi de comportement développée à partir du concept des contraintes effectives plastiques ne contient que deux paramètres plastiques (module d'écrouissage et pente de la droite critique. Le modèle est validé sur des chemins de contrainte homogènes (hydrostatique, triaxial drainé et triaxial non drainé et comparé à des essais expérimentaux obtenus à partir d'essais conventionnels de laboratoire. Ensuite, une version simplifiée du modèle est

  10. Identification and isolation from either adult human bone marrow or G-CSF-mobilized peripheral blood of CD34(+)/CD133(+)/CXCR4(+)/ Lin(-)CD45(-) cells, featuring morphological, molecular, and phenotypic characteristics of very small embryonic-like (VSEL) stem cells.

    Sovalat, Hanna; Scrofani, Maurice; Eidenschenk, Antoinette; Pasquet, Stéphanie; Rimelen, Valérie; Hénon, Philippe

    2011-04-01

    Recently, we demonstrated that normal human bone marrow (hBM)-derived CD34(+) cells, released into the peripheral blood after granulocyte colony-stimulating factor mobilization, contain cell subpopulations committed along endothelial and cardiac differentiation pathways. These subpopulations could play a key role in the regeneration of post-ischemic myocardial lesion after their direct intracardiac delivery. We hypothesized that these relevant cells might be issued from very small embryonic-like stem cells deposited in the BM during ontogenesis and reside lifelong in the adult BM, and that they could be mobilized into peripheral blood by granulocyte colony-stimulating factor. Samples of normal hBM and leukapheresis products harvested from cancer patients after granulocyte colony-stimulating factor mobilization were analyzed and sorted by multiparameter flow cytometry strategy. Immunofluorescence and reverse transcription quantitative polymerase chain reaction assays were performed to analyze the expression of typical pluripotent stem cells markers. A population of CD34(+)/CD133(+)/CXCR4(+)/Lin(-) CD45(-) immature cells was first isolated from the hBM or from leukapheresis products. Among this population, very small (2-5 μm) cells expressing Oct-4, Nanog, and stage-specific embryonic antigen-4 at protein and messenger RNA levels were identified. Our study supports the hypothesis that very small embryonic-like stem cells constitute a "mobile" pool of primitive/pluripotent stem cells that could be released from the BM into the peripheral blood under the influence of various physiological or pathological stimuli. In order to fully support that hBM- and leukapheresis product-derived very small embryonic-like stem cells are actually pluripotent, we are currently testing their ability to differentiate in vitro into cells from all three germ layers. Copyright © 2011 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.

  11. CSR kui äristrateegia osa / Tuuliki Kasonen-Lins

    Kasonen-Lins, Tuuliki

    2008-01-01

    Autor selgitab, et ettevõtte ühiskondlik vastutus ei ole kord aastas korraldatav heategevuskampaania. Näitena ettevõtte ühiskondlikust vastutusest nimetab autor panustamist tööjõu koolitusse või töötute sotsiaalsete gruppidega tegelemisse

  12. Fair trade - Õiglane kaubandus / Tuuliki Kasonen-Lins

    Kasonen-Lins, Tuuliki

    2007-01-01

    Õiglase kaubanduse liikumise ajaloolisest arengust. Fair trade on kaubandusvõrk, kus kaubeldakse arengumaades inimväärsetes tingimustes toodetud ja sealsetelt kaupmeestelt õiglaste hindadega ostetud kaupadega. Fair Trade Euroopas

  13. Developmental Test of the Honeywell Laser Inertial Navigation System (LINS)

    1975-11-01

    The ISA contains three Systron Donner 4841F-10 single axis accelerometers and three Honeywell GG1300- AEOI laser gyros in an orthogonal strapdown...DIAG.1,kM AN.D PHYSICAL CHARACTERISTICS The GG1300- AEOI laser gyro, shown schematically in Figure 2, has the following performance goals which were

  14. Allelopathic effect of Jatropha curcas (Lin) leachate on germination ...

    Laboratory study was conducted using sterilized petri dishes with double layer of Whatman filter paper at averagely 27oC and 70% humidity. An interval of 24, 48, 76 and 92 hours were recorded on germination studies while radicle and shoot lengths at 92nhours respectively. Decreased in germination percentage, shoot ...

  15. 75 FR 842 - Action Affecting Export Privileges: Hailin Lin

    2010-01-06

    ... People's Republic of China (PRC) in violation of U.S. export control laws by failing to obtain the proper... (50 U.S.C. 1701-1706). Charge 1: 15 CFR 764.2(d)--Conspiracy To Export Electronic Components to the... was done so that Shipper's Export Declarations, which are filed with the U.S. Government and which...

  16. Effects of potassium behaviour in soils on crop absorption | Lin ...

    Potassium (K) is one of the three major elements that play important roles in plants, such as maintaining turgor of cells, promoting activation of enzymes, and improving efficiency of photosynthesis. The types of K in soil may affect the plant absorption of K. K in soils includes K minerals, K in layered silicates (clay minerals), ...

  17. Yi lin cuo yao(Essentials of Medical Works) and its historical materials of medical exchanges between China and Korea%朝鲜《医林撮要》所载中朝医学交流史料研究

    梁永宣

    2001-01-01

    由朝鲜内医郑正先撰、杨礼寿校正,成书于16~17世纪时期的《医林撮要》一书,共13卷128门,它引用了大量李朝前期的朝鲜医书及当时已成书的中国医书资料,是一部非常切合临床应用的综合性方书。特别是书中所收载的“中朝质问方”和“中朝传习方”中的方剂,若干处与中国宋代医书《仁斋直指方论》等有诸多联系,是中国和朝鲜医学交流过程中的重要记录。但它与记载中朝两国政府官员之间医学质问的傅懋光《医学疑问》毫不相关。%Yi lin cuo yao,including 13 chapters and 128 categories,was written by Zheng Zhengxian and collated by Yang Lishou,both Korean imperial physicians in the 16-17th centuries.With notation of a number of the Chinese and Korean medical books and materials in the first decade of the Li dynasty,this book is a comprehensive prescription work,very useful to clinical application.Especially with several points of the formulas from Zhong chao zhi wen fang (Sino-Korean Prescriptions of Questioning) and zhong chao chuan xi fang (Sino-Korean Prescriptions of Questioning) recorded in this book connected with Ren zhai zhi zhi fang lun (Renzhai's Comprehensive Prescriptions) in the Song dynasty.This book is an important record of the exchanges on medical ideas between China and Korea.However,it has nothing to do with Yi xue yi wen (Questions on Medicine) by Fu Maoguang,which records the questions and answers between Chinese and Korean officials.

  18. 專論/From the Viewpoints of People’s Need of Information and Social Activities toDiscuss the Difference between Public Library and Internet/葉乃靜(Nei-Ching Yeh

    葉乃靜 Nei-Ching Yeh

    2009-10-01

    Full Text Available This paper aims to discuss the difference and the similarities between the public library and the Internet service, especially focused on web 2.0 websites, and discovered some helpful techniques from the Internet, which could be derived to develop the system used in the public library. This study applied comparative research method to elicit the difference between the public library and Internet service. Based on the following viewpoints, the characteristics of people’s daily life, people’s needs for information and social interaction, and types of resources, this paper elucidated the difference between public libraries and Internet service. This paper suggests that the public library could examine the information defined by the user and know its application in daily life to recognize its method of application in service designs. 本文旨在探討公共圖書館與網路服務的異同,尤其關注web 2.0 網站。基於網路的受歡迎,引發作者試圖由網路服務尋找對公共圖書館服務之啟發動機。本文採用比較研究法的精神,了解公共圖書館與網路服務的差異,再找出可能對提升公共圖書館服務的歡迎度有助益的策略建議。本文進行比較研究的基礎如下:日常生活的特徵、民眾對資訊和社會互動的基礎、公共圖書館與網路提供之資源的類型。文末建議,公共圖書館可以審視讀者認知的資訊,及其如何被應用於日常生活,再由此思考公共圖書館的可行作法。 頁次:4-13

  19. Chuancheng yu gengxin: Liu Mei sheng yu Minguo shiqi de shixue%传承与更新:留美生与民国时期的史学

    李春雷

    2008-01-01

    @@ As it has long been acknowledged that historians do not simply write objectivehistories, but are themselves products of Specific times and places, there is littlequestion that histories of historiography can provide important insights. ProfessorLi Chunlei, of Tianjin Polytechnic University, contributes to our understandingof the origins of the modem discipline of history in China by focusing on theimportant role of returned students from the U.S. in fostering its developmentand shaping its direction.

  20. Re ‘Luminescence dating of K-feldspar from sediments: a protocol without anomalous fading correction’ by Bo Li and Sheng-Hua Li

    Thomsen, Kristina Jørkov; Murray, Andrew; Jain, Mayank

    2012-01-01

    Have recently proposed a new measurement procedure (MET-pIRIR) for luminescence dating using feldspar; they argue that this procedure reduces anomalous fading to negligible levels, and that it is a significant improvement over existing protocols (pIRIR290). Here we compare the measured equivalent...

  1. Punding following posterior cerebral artery infarction: a case report and review of literature

    Lin CI

    2017-03-01

    Full Text Available Cho-I Lin,1 Yu-Ching Lin,1–3 Wei-Chih Lien,1 Pei-Chun Hsieh,1 Sheng-Han Lin,1 Ta-Shen Kuan1,2 1Department of Physical Medicine and Rehabilitation, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 2Department of Physical Medicine and Rehabilitation, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 3Medical Device Innovation Center, National Cheng Kung University, Tainan, Taiwan Introduction: Punding is a complex stereotyped behavior, characterized by excessiveness, non-goal orientation, and repetitiveness. It is mostly associated with Parkinson’s disease, and very few cases in non-Parkinson’s disease have been reported. We report a case of punding associated with supratentorial ischemic stroke.Case presentation: We present a 70-year-old man with left posterior cerebral artery infarction with quetiapine-induced punding manifesting as repetitive unidirectional body turning. Remission of punding behavior ensued after cessation of quetiapine and administration of clonazepam.Conclusion: This case describes the clinical course of quetiapine-induced punding in a patient with left posterior cerebral artery infarction. It suggests clonazepam may serve as a treatment option for poststroke punding. Keywords: punding, stereotyped behavior, stroke, quetiapine, clonazepam

  2. La structure linéaire de la matrice lexico-syntaxique du roman policier

    Alicja Hajok

    2017-12-01

    Full Text Available The purpose of this article is to analyse the lexical and syntactic structures typical of crime novels. The conducted research will make it possible to distinguish the lexical and syntactic matrix of the genre, with the aim of checking whether the linear order of the matrix-creating elements is aleatory or stable. The study focuses on two dimensions: semantic and lexico-syntactic.

  3. Recension af Lin Prøitz Selvbilde: Fra selvportet til #selfie

    Fausing, Bent

    2017-01-01

    Anmeldelse af katalog til udstilling om selfies i Oslo i 2016-2017. Anmeldelsen er koncentreret omkring tilgangen til selfies, som via koncentrationen om litteratur efter 2015 og omkring narcissisme forfejler sit mål og reducerer selfiens betydningsområder....

  4. General k-opt submoves for the Lin-Kernighan TSP heuristic

    Helsgaun, Keld

    2009-01-01

    Local search with k-exchange neighborhoods, k-opt, is the most widely used heuristic method for the traveling salesman problem (TSP). This paper presents an effective implementation of k-opt in LKH-2, a variant of the Lin–Kernighan TSP heuristic. The effectiveness of the implementation...

  5. National Waterway Network (line), Geographic WGS84, BTS (2006) [usace_nav_waterway_lin_BTS_2006

    Louisiana Geographic Information Center — The National Waterway Network is a comprehensive network database of the nation's navigable waterways. The data set covers the 48 contiguous states plus the District...

  6. Cobordism Obstructions to Vector Fields and a Generalization of Lin's Theorem

    Svane, Anne Marie

    Atiyah and Dupont have studied the existence of linearly independent vector fields on manifolds by means of K-theory. They obtained the complete conditions for up to three independent vector fields. In the thesis, we try to copy their approach using certain spectra related to cobordism theory. We...

  7. Pediatrik obezite ve insülin direncine beslenme tedavisi yaklaşımı

    ÖZÇELİK ERSÜ, Dilek; KIZILTAN, Gül

    2015-01-01

    Nowadays, obesity has became a major public health problem that is threatening this century. The incidence of obesity is increasing in population of all ages. It is a serious disease which is seen with disease charactized by chronic comorboid and takes effect on not only adults but also children and adolescents. This is a global problem also has affects especially at urban areas of the low- and middle-income countries. Those who used to be overweight or obese in their childhood are likely to ...

  8. Improving characteristics of goat milk yogurt drink fortified by mangosteen rind (Garcinia mangostana Lin.) extract

    Wibawanti, J. M. W.; Rinawidiastuti; Arifin, H. D.; Zulfanita

    2018-01-01

    Peranakan Etawah (PE) milk is highly nutritive goaty flavour make it not preferable by consumer. Processing of yogurt drink made PE goat milk enhances palatability. Goat yogurt drink can be supplemented high antioxidantive activity by mangosteen rind extract. Comletely Randomized Design (CRD) was throughout the research with different concentrations of mangosteen rind extract (0, 1, 2, 3, and 4% (v/v). The organoleptic analysis showed the significant enhancement by fortification with mangosteen rind extract. The highest antioxidant activity was shown on the yogurt drink 4% v/v of mangosteen extract. In conclusion, the fortification of mangosteen rind extract was enhanced of characteristics of yogurt drink.

  9. Field lin topology in the dayside cusp region inferred from low altitude particle observations

    Soeraas, F.

    1977-12-01

    Dayside low altitude satellite observations of the pitch angle and energy distribution of electrons and protons in the energy range 1 keV to 100 keV during quiet geomagnetic conditions reveal that at times there is a clear latitudinal separation between the precipitating low energy (keV) electrons and protons, with the protons precipitating poleward of the electrons. The high energy (100keV) proton precipitation overlaps both the low energy electron and proton precipitation. These observations are consistent with a model where magnetosheath particles stream in along the cusp field lines and are at the same time convected poleward by an electric field. Electrons with energies of a few keV move fast and give the ''ionospheric footprint'' of the distant cusp. The protons are partly convected poleward of the cusp and into the polar cap. Here the mirroring protons populate the plasma mantle. Equatorward of the cusp the pitch angle distribution of both electrons and protons with energies above a few keV have a pancake shaped distribution indicating closed geomagnetic field lines. The 1 keV electrons penetrate into this region of closed field line structure maintaining an isotropic pitch angle distribution. The intensity is, however, reduced with respect to what it was in the cusp region. It is suggested that these electrons, the lowest measured on the satellite, are associated with the entry layer.(Auth.)

  10. Lin-Na and Yong-Xiu Afr J Tradit Complement Altern Med. (2014) 11 ...

    cadewumi

    Evaluation of anti-athletic fatigue activity of Schizandra chinensis aqueous extracts in mice. Afr J Pharm Pharmacol 3: 593-597. 4. Cao, Y., Hu, Y., Liu, P., Zhao, H.X., Zhou, X.J., and Wei, Y.M. (2012). Effects of a Chinese traditional formula Kai Xin San (KXS) on chronic fatigue syndrome mice induced by forced wheel running ...

  11. Commande non linéaire du moteur synchrone à aimants ...

    un entrainement d'une charge mécanique à deux masses. Afin d'assurer la stabilité ... robustness of the proposed control strategy and the efficiency of nonlinear controllers operating with ..... Fuzzy Logic in Solar-Wind Hybrid Power. System ...

  12. Differences in crystallization of two LinB variants from Sphingobium japonicum UT26

    Degtjarik, O.; Chaloupková, R.; Řezáčová, Pavlína; Kutý, M.; Damborský, J.; Smatanová, I.K.

    2013-01-01

    Roč. 69, č. 3 (2013), s. 284-287 ISSN 1744-3091 Institutional support: RVO:68378050 Keywords : protein crystallization * dehalogenase Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 0.568, year: 2013

  13. Effect of soil moisture management on the quality of wax apple | Lin ...

    Wax apple (Syzygium samarngense Merr.et Perry) was one of the economically planted fruits in Taiwan. This research was conducted to evaluate the effects of different soil moisture management on increasing wax apple quality. It was preceded at two different soil properties (shallow soil and alluvial soil) in Pingtung, ...

  14. Solving Arc Routing Problems Using the Lin-Kernighan-Helsgaun Algorithm

    Helsgaun, Keld

    It is well known that many arc routing problems can be transformed into the Equality Generalized Traveling Salesman Problem (E-GTSP), which in turn can be transformed into a standard Asymmetric Traveling Salesman Problem (TSP). This opens up the possibility of solving arc routing problems using...

  15. Plant regeneration through somatic embryogenesis in three ethiopian Coffea arabica Lin. hybrids

    RA Ramos

    2009-01-01

    Abbreviations: BA (6-benzyladenine; 2,4-D (2,4-dichlorophenoxyacetic acid; IBA (indole-3-butyric acid; MS (Murashige and Skoog; NAA (naphthaleneacetic acid, GA3 (Gibberellic acid, CV (Coefficient of variation, S.E (Standard error.

  16. BEG IN SE LSVANBYBE LV ERTA LIN G * „Vertaal beteken twee ...

    Test

    RoSENZWEtG, wat tesame met MARTIN BuBER 'n uiters merkwaardige. *Lesing gehou ... Dit het ook LuTHER, die Bybelvertaler vir die Duitse volk, wel goed ...... king en die kleur van die oorspronklike behou word selfs al sou daar mee aan ...

  17. La Physique du Futur Collisionneur Linéaire e+e- Partie I

    CERN. Geneva

    2004-01-01

    Depuis la fin des années 80, une grande partie de notre communauté scientifique penche pour un collisionneur électron-positon avec une énergie dans le centre de masse pouvant aller jusqu'à 500 GeV et même 1 TeV. Les technologies possibles et le programme de Physique aux différentes énergies seront détaillés, avec un accent sur les points forts (mesures de précision, secteur de Higgs) et les faiblesses de cet outil.

  18. The sup 8 Li(n,. gamma. ) sup 9 Li reaction and primordial nucleosynthesis

    Mao, Z Q; Champagne, A E [Princeton Univ., NJ (USA). Dept. of Physics

    1991-01-01

    Shell-model calculations, using both p-shell and spd-shell interactions, have been used to predict the spectroscopic properties of low-lying states in {sup 9}Li. From this information, we have obtained new estimates for the rate of the {sup 8}Li(n,{gamma}){sup 9}Li reaction, which may act to limit the production of heavy elements during an inhomogeneous big bang. The two calculations produce reaction rates which differ by about a factor of 2 at the temperatures of interest, demonstrating the uncertainties in this approach. However, the spd calculation appears to be the more reliable of the two. (orig.).

  19. 'Pays' -'Land'-'Yuan Lin'. The power of landscape (architecture) terms

    Bruns, D.; Brink, van den A.

    2012-01-01

    In order to continue building a common body of knowledge, landscape architecture researchers and practitioners must refer to the same fundamental concepts – particularly in those instances where different words are used to describe them. This paper puts the focus on ‘landscape’, probably the most

  20. 78 Rôle hydrogéologique des linéaments structuraux en milieu ...

    TEDDY

    Recherche des Sciences de la Terre et des Ressources Minières, (UFR- STRM) Université ... géométriques des blocs et des débits des forages a permis de mettre en évidence le rôle hydrogéologique .... d'altitude moyenne égale à 200 m et inclinée vers la mer au sud avec une pente moyenne autour de 2 %. Le.

  1. 77 FR 18862 - Zhiwei Lin, M.D.; Decision and Order

    2012-03-28

    ... authority to dispense controlled substances in California, the State in which he practices medicine and... that his ``request to set aside [the] previous ruling is without legal authority.'' Id. at 3. The ALJ... practices medicine and holds his DEA registration, and thus he no longer meets an essential condition for...

  2. From lin-Benzoguanines to lin-Benzohypoxanthines as Ligands for Zymomonas mobilis tRNA-Guanine Transglycosylase: Replacement of Protein-Ligand Hydrogen Bonding by Importing Water Clusters.

    Barandun, L.J.; Immekus, F.; Kohler, P.C.; Tonazzi, S.; Wagner, B.; Wendelspiess, S.; Ritschel, T.; Heine, A.; Kansy, M.; Klebe, G.; Diederich, F.

    2012-01-01

    The foodborne illness shigellosis is caused by Shigella bacteria that secrete the highly cytotoxic Shiga toxin, which is also formed by the closely related enterohemorrhagic Escherichia coli (EHEC). It has been shown that tRNA-guanine transglycosylase (TGT) is essential for the pathogenicity of

  3. Linóleo como revestimento de piso: processos construtivos, execução e patologia

    Bastos, Raquel Figueiredo

    2016-01-01

    Dissertação para obtenção do grau de Mestre em Engenharia Civil na Área de Especialização em Edificações Atualmente procura-se construir e reabilitar recorrendo a materiais com qualidade e durabilidade, nomeadamente nos revestimentos de piso, uma vez que são usados de modo permanente e estão sujeitos a elevadas ações mecânicas. A preocupação ambiental também está presente, havendo o cuidado de utilizar materiais sustentáveis que não prejudiquem o ambiente, t...

  4. Comparisons of phaseolin type and α-amylase inhibitor in common bean(Phaseolus vulgaris L.)in China

    Yang Yao; Yibo Hu; Yingying Zhu; Yue Gao; Guixing Ren

    2016-01-01

    The objective of this study was to characterize the phaseolin type and a-amylase(αAI) level in common bean(Phaseolus vidgaris L.) accessions deposited in the Chinese National Genebank.The 40 accessions sampled were common varieties originating in Asia,North America,South America,Europe,and Africa.No Inca(I-) phaseolin was observed in the accessions.Only four accessions contained Tendergreen(T-) phaseolin and the remaining36 contained Sanilac(S-) phaseolin.aAI proteins extracted from nine accessions showed higher a-amylase inhibitory activity than the control(Phase 2,IC50 = 0.65 μg).These common bean accessions have potential use as nutraceutical ingredients.

  5. 深切悼念林耀基教授%In Deep Memory of Prof. Lin Yaoji

    吴祖强

    2009-01-01

    3月16日,星期一清晨,早餐后不久便接到王次炤院长电话,不似平时听惯那样。沉静的语音立即引起了我的不安,感到可能出了什么事情。果然,他略带哽咽地和我说:“刚才从林耀基老师家出来,他今天凌晨去世了……”,

  6. PASS Reference Set Application: Lin UW (2010) TMPRSS2-ERG-PCA-PASS — EDRN Public Portal

    Active surveillance is used to manage low-risk prostate cancer. Both PCA3 and TMPRSS2:ERG are promising biomarkers that may be associated with aggressive disease. This study examines the correlation of these biomarkers with higher cancer volume and grade determined at the time of biopsy in an active surveillance cohort.

  7. Influence of various doses of gamma irradiation on the germination and growth of mango (mangifera indica lin) stones

    Hafiz, I.A.; Malik, F.A.; Ahmad, S.; Asi, A.A.; Khan, M.

    2004-01-01

    Mango stones of the cultivar, Dusehri were administered the Gamma irradiation sourced from cobalt-60 with the doses of 0, 2.5, 5.0, 7.5, 10.00, 12.50 and 15.00 Krd. The results had revealed that the germination percentage was significantly different amongst the treatments, which was slightly improved at 2.5 Krd with the value of 87. 5 %, compared with control (70.25 %), but this pattern showed the reduced trend at higher levels of radiation doses. Germination percentage had geared the negative trend beyond the dose of 2. 5 Krd. Inhibitory effects of radiation were observed pertinent to the average height of seedlings. However, primary leaves appeared serrated in the seedlings emerged from the treated seeds, which turned normal in the subsequent growth of flushes. A new characteristic of lateral branching instead of keeping a single stem was exhibited in the seedlings derived from the treated seeds. The induction of the trait may be used to alter the structure/framework/pattern of the tree canopy. (author)

  8. La filière lin oléagineux française : panorama et perspectives

    Labalette Françoise

    2011-05-01

    Full Text Available Linseed oil crop production does not succeed in reaching stable acreage in France and does not meet the demand coming from users which incorporate linseeds, which display high content in omega 3 (alpha-linolenic acid, in animal feeding in order to deliver food enriched in omega 3 by natural way (dairy products, eggs, ham.... However, several driving forces should encourage this crop, like the shortfall in linseeds in the European Union and the environmental changes expected from agriculture. That is why the French oilseed crop organisation (Onidol and the French technical institute for oilseed crops (Cetiom launched in 2008 a study about the linseed situation in France. Aim of this work was to get a better understanding of each stage of the linseed chain production from the linseed cultivation to the users and to draw perspectives for the future of this crop in France. To do that a large survey was carried out according to methods adapted to each considered sector. A great attention was given to the progress of the variety offer because the yield gap between linseed and other crops in the rotation is probably one of the most important factors explaining the crop stagnation in France. The synthesis presented in the present paper allows identifying encouraging signals for the future and points the major drawbacks to overcome and the main advantages to take advantage from for developing linseed in France.

  9. Dal mondo dell’arte al regno delle ombre (e ritorno. Arthur Danto, Maya Lin e la bellezza interna

    Filippo Fimiani

    2012-05-01

    Full Text Available Arthur Danto asserts that Maya Lin’s Vietnam Veterans Memorial in Washington embodies the rhetoric paradigm of internal beauty’s meaning. However, the relationship to the Kant’s pulchritudo adhaerens is not an easy one: Danto’s recalls against the self-referent formalism of Greenberg’s Modernism and his tacit issues about the environmental non-monumentality of Richard Serra’s Minimalism, are, most importantly, haunted by the unquestioned spectral logic of the image embodiment. The beholders’ reflecting shape on the funeral Wall is, finally, both a pathetic index and a medial incarnation (Verkörperung of the underworld.

  10. L'effet thérapeutique de l'huile de lin « linum usitatissimum » sur l ...

    client

    l'hypertriglycéridémie et l'hypercholestérolémie chez des rats obèses âgés .... complétées par le test de Tukey afin de classer et comparer les moyennes deux a ..... HARRIS, Fish oils and plasma lipid and lipoprotein metabolism in humans: A ...

  11. Serum levels of triiodothyronine (T3) and thyroxine (T4) in buffalo (Bubalus bubalis Lin.) raised in Amazon region

    Silva, A.O.A. da.

    1991-08-01

    Through the use of radioimmunoassay (RIA) it was determined blood serum concentration of triiodothyronine (T 3 ) and thyroxine (T 4 ) (n=78) for two different water buffalo racial groups. Blood serum was collected from young and adult animals belonging to two farms in Castanhal country, state of Para, Brazil, through the year of 1988. The serum levels of T 3 and T 4 were statistically correlated with climatic parameters, e.g., pluviometric precipitation, environmental temperature, humidity, light intensity variation and physiological factors such as age, breed and sex. It was identified two seasons during experiment, one season the rainfall period with high precipitation rates and the other one was considered as dry season, with low precipitation rates. The average rate of temperature and humidity have shown no significant statistic difference between the two seasons. On the other hand, it was found a significant relationship between luminosity and seasons, since when the luminosity decreases the pluviometric rates increases. (author). 51 refs, 15 figs, 15 tabs

  12. Limites de bruit quantique et de non-linéarité du canal de communication optique

    Desurvire, Emmanuel

    2003-02-01

    We analyze the information-capacity limitations of the optical communication channel, as determined by noise accumulation from optical amplification and nonlinear wave-mixing. We review the concepts of signal-to-noise ratio and entropy for binary-coded and continuous communications, leading to a definition of ultimate capacity for the optically-amplified channel. A unified quantum model, describing both amplification and nonlinearity limitations, makes possible to determine the power transmission window within which the channel capacity can be maximized. To cite this article: E. Desurvire, C. R. Physique 4 (2003).

  13. Genetic algorithm with Lin-Kernighan heuristic as a substep of solving the multinomenclature vehicle routing problem

    T.A. Yakovleva

    2011-05-01

    Full Text Available This paper is dealing with the vehicle routing problem, where different types of vehicles are managing to deliver different types of products. Three step heuristic with genetic algorithm is proposed for solving the problem.

  14. Enhancement of tendon–bone healing via the combination of biodegradable collagen-loaded nanofibrous membranes and a three-dimensional printed bone-anchoring bolt

    Chou YC

    2016-08-01

    Full Text Available Ying-Chao Chou,1,2 Wen-Lin Yeh,2 Chien-Lin Chao,1 Yung-Heng Hsu,1,2 Yi-Hsun Yu,1,2 Jan-Kan Chen,3 Shih-Jung Liu1,2 1Department of Mechanical Engineering, Chang Gung University, 2Department of Orthopedic Surgery, Chang Gung Memorial Hospital, 3Department of Physiology and Pharmacology, Chang Gung University, Taoyuan, Taiwan Abstract: A composite biodegradable polymeric model was developed to enhance tendon graft healing. This model included a biodegradable polylactide (PLA bolt as the bone anchor and a poly(D,L-lactide-co-glycolide (PLGA nanofibrous membrane embedded with collagen as a biomimic patch to promote tendon–bone interface integration. Degradation rate and compressive strength of the PLA bolt were measured after immersion in a buffer solution for 3 months. In vitro biochemical characteristics and the nanofibrous matrix were assessed using a water contact angle analyzer, pH meter, and tetrazolium reduction assay. In vivo efficacies of PLGA/collagen nanofibers and PLA bolts for tendon–bone healing were investigated on a rabbit bone tunnel model with histological and tendon pullout tests. The PLGA/collagen-blended nanofibrous membrane was a hydrophilic, stable, and biocompatible scaffold. The PLA bolt was durable for tendon–bone anchoring. Histology showed adequate biocompatibility of the PLA bolt on a medial cortex with progressive bone ingrowth and without tissue overreaction. PLGA nanofibers within the bone tunnel also decreased the tunnel enlargement phenomenon and enhanced tendon–bone integration. Composite polymers of the PLA bolt and PLGA/collagen nanofibrous membrane can effectively promote outcomes of tendon reconstruction in a rabbit model. The composite biodegradable polymeric system may be useful in humans for tendon reconstruction. Keywords: polylactide–polyglycolide nanofibers, PLGA, collagen, 3D printing, polylactide, PLA, bone-anchoring bolts, tendon healing

  15. 75 FR 27185 - Revisions to the Authorization for Validated End-User Applied Materials China, Ltd.

    2010-05-14

    ... Service Center, No. 1 North Di Sheng Street, BDA, Beijing, China 100176. Applied Materials South East Asia..., Shanghai, China 201203. Applied Materials (China), Inc.--Beijing Depot, No. 1 North Di Sheng Street, BDA... Di Sheng Street, BDA Beijing, China 100176. Applied Materials South East Asia Pte. Ltd.-- Wuxi Depot...

  16. [Textual research on Chen Ye and his Jia cang jing yan fang (Family-preserved Empirical Recipes) of the Song Dynasty].

    Zhang, Xuedan; Zhang, Ruqing; Chen, Dexing

    2014-01-01

    Chen Ye, an official of the Southern Song Dynasty, also known as Chen Rihua as his styled name, was born in Changle, Fuzhou in the reign of Shaoxing, and died during the reign of Duanping. He had been consecutively in the positions of Jiang shi lang (Court Gentleman for Ceremonial Service), Zhi zhou (Prefect) of Lingding, the Ti xing (Judicial Commissioner) of Guangdong, the Zong ling (Overseer-general) of Sichuan, Shan ding (Reviser), Shu lin and other positions in Tongzhou, Yuanzhou. His works included 1 volume of Gu ling xian sheng nian pu (Mr. Guling's Chronological Biography), 1 volume of Tan xie (On Humor), 1 volume of Shi hua (Poetry), 8 volumes of Jin yuan li shu (Jin Yuan's Smart Technique), 3 volumes of Yi jian zhi lei bian (Classified Compilation of Yijian's Annals), (Zeng guang) Suo sui lu (Augmented Records of Trivial Matters), 5 volumes of Jia cang jing yan fang (Family-preserved Empirical Recipes). He also compiled the 8-volume Yin jiang zhi (Yinjiang's Annals), published the 2-volume Jia cang ji yao fang (Collected Essential Recipes from Family Preservation), and other proses and poetry. Jia cang jing yan fang was a formulary compiled by Chen Ye, which was lost. Altogether 74 of its recipes were cited in Fu ren da quan liang fang (Complete Effective Prescriptions for Women's Diseases), Shou qin yang lao shu (A Book for Pursuing Seniors' Longevity and Healthcare), Pu ji fang (Prescriptions for Universal Relief) and Yong le da dian (Yongle Encyclopedia).

  17. RETRACTED: Growth behavior and microstructure evolution of ZnO nanorods grown on Si in aqueous solution

    Liou, Sz-Chian; Hsiao, Chi-Sheng; Chen, San-Yuan

    2005-02-01

    This article has been retracted: please see Elsevier Policy on Article Withdrawal. This article has been retracted at the request of the Editor-in-Chief. Two papers published in the Journal of Crystal Growth are being retracted due to a case of misrepresentation and reuse of data. A reader of the Journal has brought to our attention the reuse of data within two published papers: Growth behavior and microstructure evolution of ZnO nanorods grown on Si in aqueous solution, Sz-Chian Liou, Chi-Sheng Hsiao, San-Yuan Chen, Journal of Crystal Growth 274 (2005) 438-446. Nucleation and growth behavior of well-aligned ZnO nanorods on organic substrates in aqueous solutions, Chin-Ching Lin, San-Yuan Chen, and Syh-Yuh Cheng, Journal of Crystal Growth 283 (2005) 141-146. In these papers the same transmission electron micrograph was used to describe two different experimental situations and results bringing into question the content of these papers. The reuse of data without proper attribution is not acceptable within the scientific publishing community. In the present case, this is compounded by the attribution of the micrograph to a different experimental situation and drawing, as a result, new conclusions from data obtained from different samples. Such behavior undermines the integrity of the scientific publishing endeavor and is not acceptable. The authors are responsible for the content of their papers.

  18. Alpinetin inhibits lung cancer progression and elevates sensitization drug-resistant lung cancer cells to cis-diammined dichloridoplatium

    Wu L

    2015-11-01

    Full Text Available Lin Wu, Wei Yang, Su-ning Zhang, Ji-bin Lu Department of Thoracic Surgery, Sheng Jing Hospital of China Medical University, Shenyang, People’s Republic of China Objective: Alpinetin is a novel flavonoid that has demonstrated potent antitumor activity in previous studies. However, the efficacy and mechanism of alpinetin in treating lung cancer have not been determined. Methods: We evaluated the impact of different doses and durations of alpinetin treatment on the cell proliferation, the apoptosis of lung cancer cells, as well as the drug-resistant lung cancer cells. Results: This study showed that the alpinetin inhibited the cell proliferation, enhanced the apoptosis, and inhibited the PI3K/Akt signaling in lung cancer cells. Moreover, alpinetin significantly increased the sensitivity of drug-resistant lung cancer cells to the chemotherapeutic effect of cis-diammined dichloridoplatium. Taken together, this study demonstrated that alpinetin significantly suppressed the development of human lung cancer possibly by influencing mitochondria and the PI3K/Akt signaling pathway and sensitized drug-resistant lung cancer cells. Conclusion: Alpinetin may be used as a potential compound for combinatorial therapy or as a complement to other chemotherapeutic agents when multiple lines of treatments have failed to reduce lung cancer. Keywords: alpinetin, cell proliferation and apoptosis, drug resistance reversal, PI3K/Akt, lung cancer

  19. Effects of a selective educational system on fatigue, sleep problems, daytime sleepiness, and depression among senior high school adolescents in Taiwan

    Chen TY

    2015-03-01

    Full Text Available Tien-Yu Chen,1,2 Yu-Ching Chou,3 Nian-Sheng Tzeng,1,2,4 Hsin-An Chang,1,2,4 Shin-Chang Kuo,1,2,5 Pei-Yin Pan,1,2 Yi-Wei Yeh,1,2,5 Chin-Bin Yeh,1,2 Wei-Chung Mao1,2,6 1Department of Psychiatry, Tri-Service General Hospital, 2School of Medicine, National Defense Medical Center, 3School of Public Health, National Defense Medical Center, 4Student Counseling Center, National Defense Medical Center, 5Graduate Institute of Medical Sciences, National Defense Medical Center, 6Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan, Republic of China Objective: The aim of the study reported here was to clarify the effects of academic pressure on fatigue, sleep problems, daytime sleepiness, and depression among senior high school adolescents in Taiwan. Methods: This cross-sectional study enrolled 757 senior high school adolescents who were classified into four groups: Grade 1 (n=261, Grade 2 (n=228, Grade 3T (n=199; Grade 3 students who had another college entrance test to take, and Grade 3S (n=69; Grade 3 students who had succeeded in their college application. Fatigue, sleep quality, daytime sleepiness, and depression were assessed using the Chinese version of the Multidimensional Fatigue Symptom Inventory – Short Form, Pittsburgh Sleep Quality Index-Taiwan Form, the Chinese version of the Epworth Sleepiness Scale, and the Chinese version of the Beck Depression Inventory®-II (BDI-II, respectively. Results: Physical, emotional, and mental fatigue scores were all higher in higher-grade groups. The Grade 3T (test students had the worst fatigue severity, and the Grade 3S (success students had the least fatigue severity. More than half of the students (60.9% went to bed after 12 am, and they had on average 6.0 hours of sleep per night. More than 30% of the students in Grade 2 (37.3% and Grades 3T/S (30.2%/30.4% possibly had daily sleepiness problems. The students in Grade 3T had the worst BDI-II score (13.27±9.24, and the Grade 3S

  20. Identification of Human Factors Concerns in Joint Strike Fighter and Training Recommendations

    2008-09-01

    thus resulting in attentional capture or tunneling. Yeh, Wickens and Seagull (1999) pointed out that the scanning cost of head-up display clutter...psychophysiological measures. International Journal of Aviation Psychology, 12(1), 3-18. 137 Yeh, M., Wickens, C.D., & Seagull , F.J. (1999, December

  1. Stereoselectivity and substrate specificity in the kinetic resolution of methyl-substituted 1-oxaspiro[2.5]octanes by Rhodotorula glutinis epoxide hydrolase

    Weijers, C.A.G.M.; Meeuwse, P.; Herpers, R.L.J.M.; Franssen, M.C.R.; Sudhölter, E.J.R.

    2005-01-01

    [GRAPHICS] The kinetic resolution of a range of methyl-substituted 1-oxaspiro[2.5]octanes by yeast epoxide hydrolase (YEH) from Rhodotorula glutinis has been investigated. The structural determinants of substrate specificity and stereoselectivity of YEH toward these substrates appeared to be the

  2. Possible lin between elevated accumulation of trace elements and canine distemper virus infection in the Caspian seals (Phoca caspica) stranded in 2000 and 2001

    Shinsuke, T.; Takashi, K.; Yasumi, A.; Tokutaka, I.; Reiji, K.

    2003-05-01

    In the Caspian Sea, a die-off of thousands of Caspian seals (Phoca caspica) occurred in 1997 and 2000. While a direct cause for these deaths seems to be canine distemper virus (CDV) infection, immunosuppression due to environmental pollutants is considered as one of the possible explanations for the development of the disease. The purpose of this work is to examine whether exposure to trace metals could be one of the factors involved in the mass mortality of Caspian seals. Concentrations of 13 trace elements weredetermined in liver, kidney and muscle of Caspian seals found stranded along the coasts of the Caspian Sea in 2000 and 2001. Concentrations of toxic elemen ts (Ag, Cd, Hg, Tl and Pb) in the Caspian seals collected in 2000 and 2001 were comparable to or lower than those in healthy Caspian seals collected in 1993 and 1998 and in seals from other regions, suggesting that these elements would not be the causative agent for the death of Caspian seals. In contrast, Zn and Fe concentrations in the stranded Caspian seals were apparently higher than those in seals from other locations. These results suggest the disturbance in homeostatic control and nutritional statu s of essential elements in the stranded Caspian seals.

  3. National Rail Network: 1:100,000 (line), Geographic WGS84, BTS (2006) [us_rail_network_100k_lin_BTS_2006

    Louisiana Geographic Information Center — The Rail Network is a comprehensive database of the nation's railway system at the 1:100,000 scale. The data set covers all 50 States plus the District of Columbia.

  4. Risques de gel accru liés à la présence d’ouvrages linéaires en remblai

    Hervé Quenol

    2008-02-01

    Full Text Available Sur un coteau, le remblai d’un ouvrage de transport, en créant un obstacle à l’écoulement naturel de l’air froid superficiel, favorise la formation d’un lac d’air froid. Au printemps, cet obstacle peut accroître le risque de gel dommageable pour les cultures qui sont vulnérables à cet aléa (vigne, arbres fruitiers…. A partir de mesures météorologiques aux échelles fines, réalisées lors des nuits froides de type « radiatives » (vent faible et ciel clair et en simulant le remblai sur une longueur conséquente par l’intermédiaire d’un bâche, il est possible d’évaluer grossièrement le différentiel thermique que va constituer cet ouvrage. Une autre méthode, basée sur la simulation de l’ouvrage en remblai, dans un SIG, et d’une validation sur le terrain aboutit à des résultats proches. Les exemples présentés ici proviennent d’études réalisées ces dernières années sur les remblais des lignes à grande vitesse du TGV Est européen (dans le vignoble de Champagne et du TGV Méditerranée (dans les terroirs arboricoles de la basse vallée de la Durance. Les résultats montrent des différences de températures de plusieurs degrés et aussi une stagnation plus longue de l’air froid superficiel en amont du remblai, ce qui peut provoquer la destruction des jeunes bourgeons. Devant l’importance des problèmes prévisibles, le Maître d’ouvrage a proposé des aménagements afin de réduire au mieux ce risque supplémentaire.By radiativ weather (weak wind and clear sky, an embankment located in below slope level generates an obstacle with the natural flow of the cold air and it develops the formation of cold air lake. In spring, this obstacle can increase the frost risk for the vulnerable cultures (vine, fruit trees.... Weather measurements on fine scales and embankment simulation (with a plastic cover or in a GIS permit to evaluate the temperature difference after the embankment implantation. The examples presented here are the impact of the embankments of high speed lines of the East European TGV (in the Champagne vineyard and of the Mediterranean TGV (in orchards of Durance Valley. The results show a temperature difference of several degrees and also a longer stagnation of cold air surface upstream of the embankment, which can cause the buds destruction. With the importance of the foreseeable problems, the building owner proposed installations in order to reduce this additional risk.

  5. Back-propagation neural network in tidal-level forecasting by Ching-PiaoTsai and Tsong-Lin Lee - Discussion

    Mandal, S.

    relevance to the practicing engineer. Such a scheme of updating parameters (connection weights in the case of neu- ral network) is not employed in the suggested ANN model; thus, the ANN model, where the parameters are estimated from only one-day data... term hourly tidal records. However, there are a number of points to be clarified in order to better understand the paper. This discussion focuses on the following four areas: (1) terminology used in the paper; (2) practical utility; (3) reliability...

  6. A mixed analog-digital radiation hard technology for high energy physics electronics DMILL (Durci Mixte sur Isolant Logico-Linéaire)

    Beuville, E; Borgeaud, P; Fourches, N T; Rouger, M; Blanc, J P; Bruel, M; Delevoye-Orsier, E; Gautier, J; Du Port de Pontcharra, J; Truche, R; Dupont-Nivet, E; Flament, O; Leray, J L; Martin, J L; Montaron, J; Borel, G; Brice, J M; Chatagnon, P; Terrier, C; Aubert, Jean-Jacques; Delpierre, P A; Habrard, M C; Potheau, R; CERN. Geneva. Detector Research and Development Committee

    1992-01-01

    The high radiation level expected in the inner regions of the high luminosity LHC detectors (gamma and neutron) will require radiation hardened electronics. A consortium between the CEA (Commissariat a l'Energie Atomique) and Thomson TMS (Thomson Composants Militaires et Spatiaux) has been created to push for the development and the industrialization of a nascent technology which looks particularly adapted to the needs of HEP electronics. This technology, currently under development at the LETI(CEA), uses a SIMOX substrate with an epitaxial silicon film. It includes CMOS, JFETs and vertical bipolar transistors with a potential multi-megarad hardness. The CMOS and bipolar transistors constitute a rad-hard BiCMOS which will be useful to design analog and digital high-speed architectures. JFETs, which have intrinsically high hardness behaviour and low noise performances even at low temperature will enable very rad-hard, low noise front end electronics to be designed. Present results, together with the improvemen...

  7. Yield stability in maize (Zea mays L. and correlations among the parameters of the Eberhart and Russell, Lin and Binns and Huehn models

    Carlos Alberto Scapim

    2000-06-01

    Full Text Available Assessment of the stability and adaptability of a genotype to different environments is useful for recommending cultivars for known conditions of cultivation and should be a requirement in breeding programs. Twenty maize (Zea mays L. cultivars were tested at eight locations in Minas Gerais by the National Center for Maize and Sorghum Research (CNPMS of the Brazilian Enterprise for Agricultural Research (EMBRAPA for two years. The experiments involved a randomized complete block design in which three procedures were used to analyze cultivar stability and adaptability. The level of association among the parameters obtained by the three methods was assessed using Spearman's rank correlation. Hybrids 'DINA 170', 'G-96C', 'C 505', 'DINA 70' and 'C 435' had a mean yield greater than 6,000 kg/ha. Eberhart and Russell's regression coefficient (betai was negative and correlated significantly (P or = 0.05, but correlated positively with Si(1 (P O conhecimento sobre a estabilidade e adaptabilidade de comportamento de genótipos contém informações muito úteis para a recomendação de cultivares para condições de cultivo conhecidas a priori, de modo que a avaliação da resposta dos genótipos às variações ambientais deve ser etapa obrigatória em programas de melhoramento. Para caracterizar 20 cultivares de milho, foram realizados dez ensaios (oito localidades do Estado de Minas Gerais, em dois anos no delineamento de blocos ao acaso, pelo Centro Nacional de Pesquisa de Milho e Sorgo (CNPMS da Empresa Brasileira de Pesquisa Agropecuária (Embrapa. Três procedimentos estatísticos foram adotados para a análise da estabilidade e adaptabilidade dos cultivares e avaliou-se o grau de associação entre os parâmetros dos três métodos por meio da correlação classificatória de Spearman. 'DINA 170', 'G-96C', 'C 505', 'DINA 70' e 'C 435' destacaram-se com produtividades médias superiores a 6.000 kg/ha. O coeficiente de regressão (betai de Eberhart e Russell foi negativo e significativamente correlacionado (P ou = 0,05, mas correlacionou-se positiva e significativamente com Si(1 (P < 0,05, indicando que genótipos mais produtivos e responsivos (com menor Pi também podem ser estáveis (com menor Si(1, embora tal situação não seja comumente observada na literatura. Huehn afirma que as estimativas de Si(1 indicam somente estabilidade, quando os dados são corrigidos. Os parâmetros de estabilidade Si(1, Si(2, Si(3 e sigma²di correlacionaram-se positiva e significativamente entre si (P < 0,01, indicando que as estimativas de estabilidade do modelo não-paramétrico de Huehn não acrescentaram maiores informações, além das obtidas pelo método de Eberhart e Russell, ao mesmo tempo que mostram que estimativas de estabilidade de modelos não-paramétricos são alternativas úteis às estimativas de modelos paramétricos. 'DINA 170', com maior média geral, caracterizou-se como um cultivar adaptado para ambientes favoráveis e permaneceu entre os mais produtivos no conjunto de ambientes avaliados. 'G-96C' comportou-se como um cultivar de média adaptação a todos os ambientes (cultivar ideal e estável, enquanto 'C 505' e 'C 435' podem ser considerados alternativos para a 'G-96C'. 'DINA 70', também de adaptabilidade geral, caracterizou-se como de baixa estabilidade.

  8. Polimorfismos en la longitud de fragmentos amplificados (AFLP´s) a partir de muestras de sangre almacenadas en tarjetas FTA® para la especie Cavia porcellus Lin. (Rodentia: Caviidae)

    Burgos-Paz, William; Rosero-Galindo, Carol; Cárdenas-Henao, Heiber; Solarte-Portilla, Carlos

    2007-01-01

    Una manera eficaz de establecer el grado de variabilidad entre y dentro de poblaciones, es a través del análisis de polimorfismos de ADN con marcadores moleculares como los AFLP`s. En este artículo se presenta una metodología que combina la utilización de tarjetas de FTA® (Whatman Bioscience, Cambridge) para colección y conservación de muestras de sangre, con los procedimientos de extracción de ADN y obtención de marcadores AFLP´s, aspectos sobre los cuales no existen antecedentes para la esp...

  9. Characterization of Lin'an montmorillonite and its application in the removal of Ni{sup 2+} from aqueous solutions

    Tan, X.L.; Hu, J.; Zhou, X.; Wang, X.K. [Inst. of Plasma Physics, Chinese Academy of Sciences, Hefei (China); Yu, S.M. [School of Chemical Engineering, Hefei Univ. of Tech., Hefei (China)

    2008-07-01

    Clay minerals have been studied extensively because of their strong sorption and complexation ability. In this work, Na-montmorillonite was characterized by using acid-base titration, XRD and FTIR in detail. Sorption of Ni(II) on Na-montmorillonite was investigated under ambient conditions as a function of pH, ionic strength, and temperature. The results indicate that sorption of Ni{sup 2+} on montmorillonite are strongly dependent on pH and ionic strength. The sorption of Ni{sup 2+} is mainly dominated by ion exchange at low pH values and by inner-sphere surface complexation at high pH values. The relationships of pH-C{sub eq}, Q-C{sub eq} and pH-Q are compared and shown clearly in a 3-D plot, and all Q-C{sub eq} data lie in a straight line with slope (- V/m) and intercept (C{sub 0}V/m). The thermodynamic parameters ({delta}H , {delta}S , and {delta}G ) are calculated from the temperature dependent sorption isotherms, and the results suggest that the sorption reaction of Ni(II) from solution to montmorillonite is endothermic and spontaneous. (orig.)

  10. Innovació en educació. De la idea a l’acció. Procés participatiu cap a l'INNED 2

    Artur Parcerisa-Aran

    2011-06-01

    Full Text Available Per al progrés de l’educació, la innovació és indispensable. Aquest concepte, que es relaciona però no s’ha de confondre amb el de canvi, no tothom l’entén igual, i això fa que sigui necessari definir quines són les característiques que ha de tenir un procés perquè es pugui considerar una innovació educativa. A partir de la preocupació per ajudar a fer que les innovacions no es quedin només en idees sinó que esdevinguin realitats a les aules i en altres espais educatius, es va engegar un procés de trobades amb professorat i altres educadors i educadores per treballar sobre la innovació educativa de cara a l’organització del II Simposi d’Innovació Educativa (INNED 2. Un dels eixos que va suscitar més interès va ser el de la innovació metodològica. En la part final de l’article es recullen una sèrie de consideracions sobre alguns àmbits que cal considerar en aquesta innovació: la implicació de l’alumnat, l’organització de l’espai i el temps, l’avaluació per aprendre i l’atenció a la diversitat.

  11. Proposition d'une méthode d'alignement de l'accélérateur linéaire CLIC

    Touzé, Thomas; Mainaud-Durand, H

    2011-01-01

    The compact linear collider (CLIC) is the particles accelerator project proposed by the european organization for nuclear research (CERN) for high energy physics after the large hadron collider (LHC). Because of the nanometric scale of the CLIC leptons beams, the emittance growth budget is very tight. It induces alignment tolerances on the positions of the CLIC components that have never been achieved. The last step of the CLIC alignment will be done according to the beam itself. It falls within the competence of the physicists. However, in order to implement the beam-based feedback, a challenging pre-alignment is required : 10 μm at 3σ along a 200 m sliding window. For such a precision, the proposed solution must be compatible with a feedback between the measurement and repositioning systems. The CLIC pre-alignment will have to be active. This thesis does not demonstrate the feasibility of the CLIC active prealignment but shows the way to the last developments that have to be done for that purpose. A metho...

  12. Commande de systèmes linéaires sous contraintes fréquentielles et temporelles – Application au lanceur flexible

    Chambon , Emmanuel

    2016-01-01

    In modern control design problems, both frequency- and time-domain requirements are usually considered such that the resulting control law satisfies the specifications. Novel non-smooth optimisation techniques can be used to achieve multiple frequency-domain specifications over a family of linear models. Examples of applications include robust control design where multiple critical models for different values of the uncertain parameters are considered. This is illustrated in this thesis manus...

  13. Release of Halide Ions from the Buried Active Site of the Haloalkane Dehalogenase LinB Revealed by Stopped-Flow Fluorescence Analysis and Free Energy Calculations

    Hladílková, Jana; Prokop, Z.; Chaloupková, R.; Damborský, J.; Jungwirth, Pavel

    2013-01-01

    Roč. 117, č. 46 (2013), s. 14329-14335 ISSN 1520-6106 R&D Projects: GA ČR GBP208/12/G016 Grant - others:GA ČR(CZ) GAP207/12/0775 Program:GA Institutional support: RVO:61388963 Keywords : access tunnel * buried active site * catalytic activity * enzyme mechanism * haloalkane dehalogenase * halide ions Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 3.377, year: 2013

  14. Caenorhabditis elegans Histone Deacetylase hda-1 Is Required for Morphogenesis of the Vulva and LIN-12/Notch-Mediated Specification of Uterine Cell Fates

    Ranawade, Ayush Vasant; Cumbo, Philip; Gupta, Bhagwati P.

    2013-01-01

    Chromatin modification genes play crucial roles in development and disease. In Caenorhabditis elegans, the class I histone deacetylase family member hda-1 , a component of the nucleosome remodeling and deacetylation complex, has been shown to control cell proliferation. We recovered hda-1 in an RNA interference screen for genes involved in the morphogenesis of the egg-laying system. We found that hda-1 mutants have abnormal vulva morphology and vulval-uterine connections (i.e., no uterine-sea...

  15. Review: SERUYA, Teresa; D´HULST, Lieven; ASSIS ROSA, Alexandra; LIN MONIZ, Maria. Translation in Anthologies and Collections (19th and 20th Centuries. Amsterdam: John Benjamins, 2013.

    Paulo Henrique Pappen

    2016-09-01

    Full Text Available http://dx.doi.org/10.5007/2175-7968.2016v36n3p351 Translation in Anthologies and Collections (19th and 20th Centuries, como outros livros que abordam a questão, é produto de um evento organizado em 2010. Ao todo, são 16 artigos no volume, agrupados em três tópicos: “Discursive practices and scholarly agency”; “National and international canonization processes”; e “Selection and censorship”, em uma obra inteiramente redigida em inglês (menos o texto do espanhol Sabio Pinilla e publicada pela John Benjamins, bom indicador do público ao qual se dirige. Uma operação acertada parece ser a que guia a escolha do título, que ao invés de tentar antecipar uma definição de “antologias traduzidas”, ou “antologias de literatura traduzida”, propõe o guarda-chuva mais abarcador da “tradução em antologias e coleções”. Ou seja, o interesse passa a ser localizar a mediação tradutiva nessas obras.

  16. Using the value of Lin's concordance correlation coefficient as a criterion for efficient estimation of areas of leaves of eelgrass from noisy digital images.

    Echavarría-Heras, Héctor; Leal-Ramírez, Cecilia; Villa-Diharce, Enrique; Castillo, Oscar

    2014-01-01

    Eelgrass is a cosmopolitan seagrass species that provides important ecological services in coastal and near-shore environments. Despite its relevance, loss of eelgrass habitats is noted worldwide. Restoration by replanting plays an important role, and accurate measurements of the standing crop and productivity of transplants are important for evaluating restoration of the ecological functions of natural populations. Traditional assessments are destructive, and although they do not harm natural populations, in transplants the destruction of shoots might cause undesirable alterations. Non-destructive assessments of the aforementioned variables are obtained through allometric proxies expressed in terms of measurements of the lengths or areas of leaves. Digital imagery could produce measurements of leaf attributes without the removal of shoots, but sediment attachments, damage infringed by drag forces or humidity contents induce noise-effects, reducing precision. Available techniques for dealing with noise caused by humidity contents on leaves use the concepts of adjacency, vicinity, connectivity and tolerance of similarity between pixels. Selection of an interval of tolerance of similarity for efficient measurements requires extended computational routines with tied statistical inferences making concomitant tasks complicated and time consuming. The present approach proposes a simplified and cost-effective alternative, and also a general tool aimed to deal with any sort of noise modifying eelgrass leaves images. Moreover, this selection criterion relies only on a single statistics; the calculation of the maximum value of the Concordance Correlation Coefficient for reproducibility of observed areas of leaves through proxies obtained from digital images. Available data reveals that the present method delivers simplified, consistent estimations of areas of eelgrass leaves taken from noisy digital images. Moreover, the proposed procedure is robust because both the optimal interval of tolerance of similarity and the reproducibility of observed leaf areas through digital image surrogates were independent of sample size. The present method provides simplified, unbiased and non-destructive measurements of eelgrass leaf area. These measurements, in conjunction with allometric methods, can predict the dynamics of eelgrass biomass and leaf growth through indirect techniques, reducing the destructive effect of sampling, fundamental to the evaluation of eelgrass restoration projects thereby contributing to the conservation of this important seagrass species.

  17. 3D-LIN: A Configurable Low-Latency Interconnect for Multi-Core Clusters with 3D Stacked L1 Memory

    Beanato, Giulia; Loi, Igor; De Micheli, Giovanni; Leblebici, Yusuf; Benini, Luca

    2012-01-01

    Shared L1 memories are of interest for tightly- coupled processor clusters in programmable accelerators as they provide a convenient shared memory abstraction while avoiding cache coherence overheads. The performance of a shared-L1 memory critically depends on the architecture of the low-latency interconnect between processors and memory banks, which needs to provide ultra-fast access to the largest possible L1 working set. The advent of 3D technology provides new opportunities to improve the...

  18. Planification des activités en logistique inverse : modélisation et optimisation des performances par une approche stochastique en programmation linéaire

    Fall , Alioune

    2016-01-01

    During the last decades, reverse logistics networks have been launched in severalindustrialized countries with the aim of preserving the environment. The implementation andmanagement of the reverse logistics concerns the different levels (strategic, tactical andoperational) existing in the framework of forward logistics for any production system. Toimprove this type of network, modeling and simulation are effective tools. After presenting astate of the art in this domain, our study focuses on...

  19. Serum levels of triiodothyronine (T{sub 3}) and thyroxine (T{sub 4}) in buffalo (Bubalus bubalis Lin.) raised in Amazon region; Niveis sericos de triiodotironina (T{sub 3}) e tiroxina (T{sub 4}) em bubalinos (Bubalus bubalis Lin.) criados na regiao Amazonica

    Silva, A O.A. da

    1991-08-01

    Through the use of radioimmunoassay (RIA) it was determined blood serum concentration of triiodothyronine (T{sub 3}) and thyroxine (T{sub 4}) (n=78) for two different water buffalo racial groups. Blood serum was collected from young and adult animals belonging to two farms in Castanhal country, state of Para, Brazil, through the year of 1988. The serum levels of T{sub 3} and T{sub 4} were statistically correlated with climatic parameters, e.g., pluviometric precipitation, environmental temperature, humidity, light intensity variation and physiological factors such as age, breed and sex. It was identified two seasons during experiment, one season the rainfall period with high precipitation rates and the other one was considered as dry season, with low precipitation rates. The average rate of temperature and humidity have shown no significant statistic difference between the two seasons. On the other hand, it was found a significant relationship between luminosity and seasons, since when the luminosity decreases the pluviometric rates increases. (author). 51 refs, 15 figs, 15 tabs.

  20. A comparison of complex sleep behaviors with two short-acting Z-hypnosedative drugs in nonpsychotic patients

    Chen LF

    2013-08-01

    Full Text Available Li-Fen Chen,1 Ching-En Lin,1–3 Yu-Ching Chou,4 Wei-Chung Mao,1,5 Yi-Chyan Chen,1–3 Nian-Sheng Tzeng1,6 1Department of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei City, Taiwan; 2Taipei Tzu Chi Hospital, The Buddhist Medical Foundation, Taipei, Taiwan; 3School of Medicine, Tzu Chi University, Hualien, Taiwan; 4School of Public Health, National Defense Medical Center, Taipei City, Taiwan; 5Institute of Brain Science, School of Medicine, National Yang-Ming University, Taipei City, Taiwan; 6Student Counseling Center, National Defense Medical Center, Taipei City, Taiwan Objective: Complex sleep behaviors (CSBs are classified as “parasomnias” in the International Classification of Sleep Disorders, Second Edition (ICSD-2. To realize the potential danger after taking two short-acting Z-hypnosedative drugs, we estimated the incidence of CSBs in nonpsychotic patients in Taiwan. Methods: Subjects (N = 1,220 using zolpidem or zopiclone were enrolled from the psychiatric outpatient clinics of a medical center in Taiwan over a 16-month period in 2006–2007. Subjects with zolpidem (N = 1,132 and subjects with zopiclone (N = 88 were analyzed. All subjects completed a questionnaire that included demographic data and complex sleep behaviors after taking hypnotics. Results: Among zolpidem and zopiclone users, 3.28% of patients reported incidents of somnambulism or amnesic sleep-related behavior problems. The incidence of CSBs with zolpidem and zopiclone were 3.27%, and 3.41%, respectively, which was significantly lower than other studies in Taiwan. Conclusion: These results serve as a reminder for clinicians to make inquiries regarding any unusual performance of parasomnic activities when prescribing zolpidem or zopiclone. Keywords: parasomnia, somnambulism, amnesic sleep-related behavior, sleepwalking, zolpidem, zopiclone

  1. Effectiveness of stress management in patients undergoing transrectal ultrasound-guided biopsy of the prostate

    Chiu LP

    2016-02-01

    Full Text Available Li-Pin Chiu,1,2 Heng-Hsin Tung,3 Kuan-Chia Lin,3 Yu-Wei Lai,1,4 Yi-Chun Chiu,1,4 Saint Shiou-Sheng Chen,1,4 Allen W Chiu1,4 1Division of Urology, Taipei City Hospital, 2University of Taipei, General Education Center, 3School of Nursing, Department of Care Management, National Taipei University of Nursing and Health Science, 4Department of Urology, National Yang-Ming University School of Medicine, Taipei, Taiwan, Republic of China Background: To assess the utilization of stress management in relieving anxiety and pain among patients who undergo transrectal ultrasound (TRUS-guided biopsy of the prostate.  Methods: Eighty-two patients admitted to a community hospital for a TRUS biopsy of the prostate participated in this case-controlled study. They were divided into an experimental group that was provided with stress management and a control group that received only routine nursing care. Stress management included music therapy and one-on-one simulation education. Before and after the TRUS biopsy, the patients’ state-anxiety inventory score, pain visual analogue scale (VAS, respiratory rate, heart rate, and blood pressure were obtained.  Results: There were no differences in baseline and disease characteristics between the two groups. The VAS in both groups increased after the TRUS biopsy, but the difference in pre- and postbiopsy VAS scores was significantly lower in the experimental group (P=0.03. Patients in both groups experienced mild anxiety before and after the biopsy, but those in the experimental group displayed a significantly greater decrease in postbiopsy state-anxiety inventory score compared to the control group (P=0.02.Conclusion: Stress management can alleviate anxiety and pain in patients who received a TRUS biopsy of the prostate under local anesthesia. Keywords: anxiety, pain, stress management, transrectal ultrasound-guided biopsy of the prostate

  2. Purple urine bag syndrome in nursing homes: Ten elderly case reports and a literature review

    Chi-Hung Lin

    2008-12-01

    Full Text Available Chi-Hung Lin1, Hsien-Te Huang1, Chia-Chang Chien1, Dong-Sheng Tzeng1,2, For-Wey Lung1,3–51Department of Psychiatry, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan; 2Graduate Institute of Occupational Safety and Health; 3Graduate Institute of Behavioral Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan; 4Department of Psychiatry, National Defense Medical Center, Taipei, Taiwan; 5Calo Psychiatric Center, Pingtung County, TaiwanAbstract: Purple urine bag syndrome (PUBS is a rare occurrence, in which the patient has a purple-colored urine bag following urinary catheterization for hours to days. Most of authors believe it is a mixture of indigo (blue and indirubin (red that becomes purple. Previous study showed that PUBS occurred predominantly in chronically catheterized, constipated women. We collected 10 elderly patients with PUBS in two nursing homes. The first two cases were identified by chart review in 1987 and 2003, and then later eight cases (42.1% were collected among 19 urinary catheterized elderly in the period between January 2007 and June 2007. In the present report, PUBS probably can occur in any patients with the right elements, namely urinary tract infection (UTI with bacteria possessing these enzymes, diet with enough tryptophan, and being catheterized. Associations with bed-bound state, Alzheimer’s, or dementia from other causes are reflections of the state of such patients who are at higher risk for UTI, and hence PUBS occurred. Although we presented PUBS as a harmless problem, prevention and control of the nosocomial catheter-associated UTIs (CAUTIs has become very important in the new patient-centered medical era. Thus, we should decrease the duration of catheterization, improve catheter care, and deploy technological advances designed for prevention, especially in the elderly cared for in nursing homes.Keyword: purple urine bag syndrome, indigo, indirubin, nursing home, bacteriuria, indoxyl sulphatase

  3. Robust aptamer–polydopamine-functionalized M-PLGA–TPGS nanoparticles for targeted delivery of docetaxel and enhanced cervical cancer therapy

    Xu GJ

    2016-06-01

    Full Text Available Guojun Xu,1–3,* Xinghua Yu,2,* Jinxie Zhang,1,2,* Yingchao Sheng,4 Gan Liu,2 Wei Tao,1,2 Lin Mei1,2 1School of Life Sciences, Tsinghua University, Beijing, 2Graduate School at Shenzhen, Tsinghua University, Shenzhen, 3School of Materials Science and Engineering, Tsinghua University, Beijing, 4Department of Orthopedic Surgery, Changshu Hospital of TCM, Changshu, People’s Republic of China *These authors contributed equally to this work Abstract: One limitation of current biodegradable polymeric nanoparticles (NPs is the contradiction between functional modification and maintaining formerly excellent bioproperties with simple procedures. Here, we reported a robust aptamer–polydopamine-functionalized mannitol-functionalized poly(lactide-co-glycolide (M-PLGA–D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS nanoformulation (Apt-pD-NPs for the delivery of docetaxel (DTX with enhanced cervical cancer therapy effects. The novel DTX-loaded Apt-pD-NPs possess satisfactory advantages: 1 increased drug loading content and encapsulation efficiency induced by star-shaped copolymer M-PLGA–TPGS; 2 significant active targeting effect caused by conjugated AS1411 aptamers; and 3 excellent long-term compatibility by incorporation of TPGS. Therefore, with simple preparation procedures and excellent bioproperties, the new functionalized Apt-pD-NPs could maximally increase the local effective drug concentration on tumor sites, achieving enhanced treatment effectiveness and minimizing side effects. In a word, the robust DTX-loaded Apt-pD-NPs could be used as potential nanotherapeutics for cervical cancer treatment, and the aptamer–polydopamine modification strategy could be a promising method for active targeting of cancer therapy with simple procedures. Keywords: dopamine, AS1411 aptamer, active targeting, polymeric NPs, enhanced cervical chemotherapy

  4. Possible association between phantom vibration syndrome and occupational burnout

    Chen CP

    2014-12-01

    Full Text Available Chao-Pen Chen,1 Chi-Cheng Wu,2 Li-Ren Chang,3 Yu-Hsuan Lin4 1Department of Education, National Taiwan University Hospital, 2Department of Family Medicine, Min-Sheng General Hospital, Taoyuan City, 3Department of Psychiatry, National Taiwan University, College of Medicine, 4Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan Background: Phantom vibration syndrome (PVS and phantom ringing syndrome (PRS occur in many cell phone users. Previous studies have indicated an association between PVS/PRS and job stress. The aim of this study was to determine if PVS/PRS were also associated with occupational burnout.Methods: This was a cross-sectional study of 384 employees of a high-tech company in northern Taiwan. They all completed a phantom vibration and ringing questionnaire, the Hospital Anxiety and Depression Scale, and the Chinese version of the Occupational Burnout Inventory.Results: Significantly more women and people with at least a college education were in the population with PRS and PVS, respectively. Anxiety and depression had no associations with PVS/PRS. Higher scores for personal fatigue, job fatigue, and service target fatigue had an independent impact on the presence of PVS, but only a higher score for service target fatigue had an independent impact on the presence of PRS.Conclusion: The independent association between work-related burnout and PVS/PRS suggests that PVS/PRS may be a harbinger of mental stress or a component of the clinical burnout syndrome, and may even be a more convenient and accurate predictor of occupational burnout. Keywords: phantom vibration syndrome, phantom ringing syndrome, occupational burnout

  5. RETRACTED: Nucleation and growth behavior of well-aligned ZnO nanorods on organic substrates in aqueous solutions

    Lin, Chin-Ching; Chen, San-Yuan; Cheng, Syh-Yuh

    2005-09-01

    Available online : 21 July 2005 This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. Two papers published in the Journal of Crystal Growth are being retracted due to a case of misrepresentation and reuse of data. A reader of the Journal has brought to our attention the reuse of data within two published papers: Growth behavior and microstructure evolution of ZnO nanorods grown on Si in aqueous solution, Sz-Chian Liou, Chi-Sheng Hsiao, San-Yuan Chen, Journal of Crystal Growth 274 (2005) 438-446. DOI: 10.1016/j.jcrysgro.2004.10.025 Nucleation and growth behavior of well-aligned ZnO nanorods on organic substrates in aqueous solutions, Chin-Ching Lin, San-Yuan Chen, and Syh-Yuh Cheng, Journal of Crystal Growth 283 (2005) 141-146. DOI: 10.1016/j.jcrysgro.2005.05.065 In these papers the same transmission electron micrograph was used to describe two different experimental situations and results bringing into question the content of these papers. The reuse of data without proper attribution is not acceptable within the scientific publishing community. In the present case, this is compounded by the attribution of the micrograph to a different experimental situation and drawing , as a result, new conclusions from data obtained from different samples. Such behavior undermines the integrity of the scientific publishing endeavor and is not acceptable. The authors are responsible for the content of their papers.

  6. 挖掘本土文化资源服务中国动画产业--潘鲁生博士访谈%Excavate the Native Cultural Resourses and Serve the Chinese Cartoon Industry --Interview with Dr PAN Lu-sheng

    潘鲁生

    2004-01-01

    @@ 记者:在中国,动画产业是一个新兴的朝阳产业,发展可谓迅速,但与美国、日本、英国、韩国等动画产业发达的国家相比,中国相对落后,这一点从各级电视台播放的动画片情况就可以看出,您能就中国动画产业现状及存在的问题做一个总体概括吗?

  7. 78 FR 35249 - Wooden Bedroom Furniture From the People's Republic of China: Final Results of Antidumping Duty...

    2013-06-12

    ....; Dongying Huanghekou Furniture Industry Co., Ltd.; Sheng Jing Wood Products (Beijing) Co., Ltd.; and Telstar... Furniture Industry Co., Ltd.; Sheng Jing Wood Products (Beijing) Co., Ltd.; and Telstar Enterprises Ltd... DEPARTMENT OF COMMERCE International Trade Administration [A-570-890] Wooden Bedroom Furniture...

  8. Electronic flight bag (EFB) : 2010 industry survey

    2010-09-01

    This document provides an overview of Electronic Flight Bag (EFB) systems and capabilities, as of June 2010. This document updates and replaces the April 2007 EFB Industry Review (Yeh and Chandra, 2007). As with the previous industry survey, the focu...

  9. Molecular genetics of schizophrenia: past, present and future

    Unknown

    leucocyte antigen; IDDM, insulin dependent diabetes mellitus; MAO, monoamine oxidase; MHC, ... In this review, we summarize the evolution of schizophrenia genetics from ...... K, Yeh J I and Hsiao K J 1999 Systematic mutation analysis.

  10. loci for phylogenetic inference and authentication among ...

    2015-04-01

    Apr 1, 2015 ... 2Department of BioIndustry Technology, Da-Yeh University, Changhua 51591, Taiwan. 3Department of Bioresources ... lignum and leaves (Huang, 1984; Ou 1989; Chang, 1995). ... Mo-tuo-wan Mountain (Hualien County).

  11. Analysis of genetic diversity and estimation of inbreeding coefficient ...

    STORAGESEVER

    2010-01-18

    Jan 18, 2010 ... Key words: Genetic diversity, microsatellite markers, Caspian horse breed. INTRODUCTION ... heterozygosity, observed and effective number of alleles at each ... computer program version 1.31 (Yeh et al., 1999). Based on ...

  12. Dicty_cDB: SLG867 [Dicty_cDB

    Full Text Available PFFKSNLN*lin**lssgci*nvnnn**liixxxxiiiiimiiynn***qfffv lfvifypliyfpr Translated Amino Acid sequence (All Fra...IS NFNNNSPFFKSNLN*lin**lssgci*nvnnn**liixxxxiiiiimiiynn***qfffv lfvifypliyfpr Hom

  13. Image-guided intensity-modulated radiotherapy for refractory bilateral breast cancer in a patient with extensive cutaneous metastasis in the chest and abdominal walls

    Lu YF

    2016-05-01

    Full Text Available Yueh-Feng Lu,1 Yu-Chin Lin,2 Kuo-Hsin Chen,3,4 Pei-Wei Shueng,1 Hsin-Pei Yeh,1 Chen-Hsi Hsieh1,5,6 1Division of Radiation Oncology, Department of Radiology, 2Division of Oncology and Hematology, Department of Medicine, 3Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, 4Department of Electrical Engineering, Yuan-Ze University, Taoyuan, 5Department of Medicine, 6Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan Abstract: Treatment for bilateral breast cancer with chest wall and abdominal skin invasion normally involves conventional radiotherapy (RT; however, conventional RT provides inadequate target volume coverage and excessive treatment of large volumes of normal tissue. Helical tomotherapy (HT has the ability to deliver continuous craniocaudal irradiation that suppresses junction problems and provides good conformity of dose distribution. A 47-year-old female with stage IV bilateral breast cancer with chest wall and pectoralis major muscle invasion, lymphadenopathy, bilateral pleural effusion, and multiple bone metastases received chemotherapy and target therapy beginning in January 2014; 4 months after the initiation of chemotherapy, computed tomography revealed progression of chest and abdominal wall invasion. A total dose of 70.2 Gy was delivered to both breasts, the chest wall, the abdominal wall, and the bilateral supraclavicular nodal areas in 39 fractions via HT. The total planning target volume was 4,533.29 cm3. The percent of lung volume receiving at least 20 Gy (V20 was 28%, 22%, and 25% for the right lung, left lung, and whole lung, respectively. The mean dose to the heart was 8.6 Gy. Follow-up computed tomography revealed complete response after the RT course. Grade 1 dysphagia, weight loss, grade 2 neutropenia, and grade 3 dermatitis were noted during the RT course. Pain score decreased from 6 to 1. No cardiac, pulmonary, liver, or intestinal toxicity

  14. Antiglycation, radical scavenging, and semicarbazide-sensitive amine oxidase inhibitory activities of acetohydroxamic acid in vitro

    Liu YH

    2017-07-01

    Full Text Available Yuh-Hwa Liu,1,2,* Yeh-Lin Lu,3,* Der-Zen Liu,4 Wen-Chi Hou5 1Division of Gastroenterology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan; 2Department of General Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; 3Department of Pharmacy, Taipei Medical University, Taipei, Taiwan; 4Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, Taipei, Taiwan; 5Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan *These authors contributed equally to this work Abstract: Advanced glycation endproducts (AGEs can promote intracellular reactive oxygen species production, and the levels of AGEs are highly correlated with cardiovascular disease and diabetes complications. Acetohydroxamic acid (acetH is a bacterial urease inhibitor drug used to treat kidney stones and infections in the urinary tract, and hydroxyurea (HU is a drug used for antineoplasm and sickle cell diseases. Both acetH and HU are hydroxamic acid derivatives. It was found that acetH and HU at 2.5 or 5 mM showed anti-AGE formation by lowering the AGEs’ fluorescent intensities and Nε-(carboxymethyllysine formation in bovine serum albumin/galactose models, and both showed better and significant differences (P<0.05 compared to the positive control of aminoguanidine. Regarding radical scavenging activities, the half-inhibition concentrations (IC50 of acetH against α,α-diphenyl-β-picrylhydrazyl radical and hydroxyl radical were 34.86 and 104.42 µM, respectively. The IC50 of acetH against semicarbazide-sensitive amine oxidase was 10.56 µM, and acetH showed noncompetitive inhibition respective to the substrates (benzylamine. The antiglycation, antioxidant, and semicarbazide-sensitive amine oxidase inhibitory activities of acetH prove that it has the potential for treating cardiovascular disease and diabetes complications and it needs further investigation in animal models. Keywords: acetH, AGEs, Nε

  15. Social support received by multidrug-resistant tuberculosis patients and related factors: a cross-sectional study in Zhejiang Province, People's Republic of China

    Chen B

    2016-06-01

    Full Text Available Bin Chen,1 Yin Peng,1 Lin Zhou,1 Chengliang Chai,1 Hui-Chi Yeh,2 Songhua Chen,1 Fei Wang,1 Mingwu Zhang,1 Tieniu He,1 Xiaomeng Wang1 1Department of Tuberculosis Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Binjiang District, Hangzhou, People’s Republic of China; 2Politics & International Relations, Social Sciences, University of Southampton, Southampton, UK Objectives: The objective of this study is to assess the social support received by patients diagnosed with multidrug-resistant tuberculosis (MDR-TB in Zhejiang Province, People’s Republic of China and the factors that may have influenced it. Methods: A total of 220 MDR-TB patients participated in the questionnaire-based survey, and the data from 212 valid questionnaires were analyzed. The respondents reported their sociodemographic status, disease features, and attitudes toward the disease. The social support rating scale was used to measure the patients’ social support scores. An Independent Samples t-test, one-way analysis of variance, and a multiple linear regression model were used to analyze the related factors for the social support scores. Result: The average social support score of each MDR-TB patient was 32.56±7.86. Participants who were single, widowed or divorced, retired, and had fewer family members and lower family income were found to have lower social support scores. Participants unwilling to disclose their disease tended to have less social support (31.59<34.23, P=0.010. Participants who perceived great help from health care workers reported higher social support rating scale scores than those who perceived no help (35.36>29.89, P=0.014. Conclusion: MDR-TB patients in Zhejiang Province were shown to have a low level of social support. Patients who were not married, had smaller families, and lower family income received less social support, suggesting that family harmony could be an important source of social support. Patients

  16. Determinación cualitativa de factores antinutricionales en las especies, Erithryna Poeppigiana (Walp. O. F, Trichanthera Gigantea (H y B, Morus Alba Lin, en la época de lluvia y seca.

    Yandy Rodríguez Ledesma

    2014-09-01

    Full Text Available El trabajo se realizó en La Finca “La Perla”, en la localidad de Topes de Collantes, municipio de Trinidad, provincia Sancti Spíritus. Se investigó la presencia de algunos grupos de metabolitos secundarios (fenoles, taninos condensados, saponinas, cianógenos y alcaloides en la biomasa comestible de tres especies arbóreas Las muestras se pesaron y se secaron al sol. El extracto se obtuvo a partir de 5 kg de muestra con 50 ml de etanol al 95 %. Para la descripción cualitativa de los resultados se observó visualmente en la muestra la opalescencia (+, Turbidez definida (++ y precipitado (+++ y, según los resultados observados se utilizaron los siguientes criterios: presencia leve +, Moderada ++ y, abundante +++. El 100% de las especies analizadas, mostraron la presencia de factores antinutricionales; los taninos, tripterpenos y saponinas fueron los metabolitos de mayor presencia en las especies estudiadas. En la época de lluvia los taninos, alcaloides, tripterpenos, antocianinas y cumarinas se encontraron en niveles bajos. En la época de sequía no se encontraron flavonoides y las antocianinas y cumarinas estuvieron en niveles bajos.

  17. Modélisation non-linéaire des effets centrifuges pour le développement de modèles réduits de composants aubagés

    Khalifeh , E; Piollet , E; Millecamps , A; Batailly , Alain

    2017-01-01

    International audience; The modeling of centrifugal stiffening effects on bladed components is of primary importance in order to accurately capture their dynamics depending on the rotor angular speed. Centrifugal effects impact both the stiffness of the component and its geometry. In the context of the small perturbation framework, when considering a linear finite element model of the component, an assumption typically made in the scientific literature involves a fourth-order polynomial devel...

  18. RNA-Binding Protein L1TD1 Interacts with LIN28 via RNA and is Required for Human Embryonic Stem Cell Self-Renewal and Cancer Cell Proliferation

    Närvä, Elisa; Rahkonen, Nelly; Emani, Maheswara Reddy; Lund, Riikka; Pursiheimo, Huha-Pekka; Nästi, Juuso; Autio, Reija; Rasool, Omid; Denessiouk, Konstantin; Lähdesmäki, Harri; Rao, Anjana; Lahesmaa, Ritta

    2012-01-01

    Human embryonic stem cells (hESC) have a unique capacity to self-renew and differentiate into all the cell types found in human body. Although the transcriptional regulators of pluripotency are well studied, the role of cytoplasmic regulators is still poorly characterized. Here, we report a new stem cell-specific RNA-binding protein L1TD1 (ECAT11, FLJ10884) required for hESC self-renewal and cancer cell proliferation. Depletion of L1TD1 results in immediate downregulation of OCT4 and NANOG. F...

  19. Analyse de la dynamique non-linéaire et du contrôle des instabilités de combustion fondée sur la "Flame Describing Function" (FDF)

    Boudy , Frédéric

    2012-01-01

    This thesis is concerned with an investigation of combustion instabilities in premixed combustors. This problem has been the subject of a continuous effort in relation with the many issues encountered in practical systems like those used in propulsion and energy production. Combustion instabilities usually arise from the coupling between combustion and acoustic eigenmodes of the system. In most cases such resonances lead to vibrations, structural fatigue and intensified heat fluxes to the cha...

  20. Efecto de la concentración de linóculo y la melaza como suplemento de la vinaza de destilería para la producción de biomasa de Candida utilis nativa

    Lady Cajo

    2011-01-01

    Full Text Available La vinaza es un residuo de las destilerías de alcohol, rico en materia orgánica y sales minerales, cuyo aprovechamiento está limitado y finalmente es vertido al alcantarillado, ocasionando contaminación, no obstante, puede constituir un sustrato par a la producción de biomasa de levaduras, utilizadas en la alimentación animal. En la presente investigación se determinó el efecto de la concentración del inóculo y la melaza como suplemento de la vinaza, para la producción de biomasa de Candida utilis nativa. Las levaduras se aislaron de panca de Zea mays L. “maíz” en agar Sabouraud glucosado, identificando el 40.23 % como C. utilis. Luego, se cultivaron en vinaza con 30 g/L de melaza, a 28 ºC, durante 24 horas, se pesó la biomasa y se seleccionó C. utilis MKJ12, debido a que alcanzó el mayor valor de 7.667 g/L. Esta levadura en concentraciones de 25, 50 y 75 mL/L de inóculo se cultivó en biorreactores tipo tanque, en lote discontinuo, conteniendo 300 mL de vinaza con 10, 30, y 50 g/L de melaza, con flujo de aire descendente (1vvm, y una incubación a 28 ºC, durante 20 horas. Con 50 mL/L de inóculo y 50 g/L de melaza se determinó el menor tiempo de generación (2.88 h y los mayores valores en el número de generaciones (6.95, tasa específica de crecimien to (0.35 h - 1 , peso de biomasa (11.78 g/L y proteína (40.15 %. Se demostró la factibilidad de la producción de biomasa de C. utilis con 5 mL/L de inóculo en vinaza suplementada con melaza.

  1. Fonctionnalisation et photopolymérisation de l'huile de lin en vue de l'élaboration de nouveaux matériaux sans émissions de composés organiques volatiles (COV)

    Zovi , Ornella

    2009-01-01

    The use of renewable sources such as vegetable oils in the elaboration of various industrial materials has been recently revitalized because of the environmental concerns. This is in this context that the elaboration of new materials mainly based on linseed oil was envisaged. These new materials were elaborated in three stages, by means of an easy and clear process. The first stage consisted in a thermal or stand reaction, followed or preceded by a chemical modification stage by maleic anhydr...

  2. Wpływ humianu sodowego z węgla brunatnego na rozwój roślin [Effect of sodium humate from lignite on plants grown under various culture conditions

    Z. Gumińska

    2015-06-01

    Full Text Available The effect of humate on the uptake of Fe-ions has already been proved. In the present paper other advantages of humate are indicated. If plants are grown in optimum conditions humate has no effect. In more concentrated solutions humate acts as a preventive factor and provides for more economical use of the solution (yield increase 40%. When high doses of P and Cu are used, humate weakens their harmful effect on plants; with pH too low or too high, it acts protectively. Humate was tested also in the transplantation of vegetatively propagated young orchid plants from sterile conditions into a natural medium; in that case it also showed a protective effect.

  3. Odporność grzyba Botryotinia fuckeliana (De Bary Whetzel (Botrytis cinerea Pers. – patogena malin, truskawek i innych roślin uprawnych na fungicydy benzimidazolowe [Resistance of Botryotinia fuckeliana (De Bary Whetzel (Botrytis cinerea Pers. to benzimidazole fungicides

    E. Arseniuk

    2015-06-01

    Full Text Available In the period 1975-1977 forms of the fungus Botrytis cinerea were found in Poland resistant to benzimidazole fungicides. The incidence of the resistant forms increases with the more intensive use of these fungicides. The resistance of Botrytis cinerea to benzimidazole compounds is a cross-resistance involving the whole group of these agents, nowithstanding wihich of them was applied. The resistance acquired by the fungus does not change its reaction to other prophylactic fungicides.

  4. Haruldaste liikide visuaalse loendamise metoodilistest probleemidest keskkonnakorralduses = Methodical problems of species`visual counting in environmental management : I koht bakalaureusetööde kategoorias / Livia Pošlin

    Pošlin, Livia

    2009-01-01

    Bakalaureusetöö eesmärgiks oli imitatsioonilise matemaatilise modelleerimise meetodeid kasutades anda soovitusi suletud maastikul liikuva väikese arvukusega populatsiooni tiheduse määramise optimaalse strateegia leidmiseks

  5. Contrôle des systèmes rapides non linéaires - Application au moteur à allumage commandé turbocompressé à distribution variable

    Colin , Guillaume

    2006-01-01

    Spark ignition engine control has become a major issue for the compliance with emissions legislation while ensuring driving comfort.Engine downsizing is one of the promising ways to reduce fuel consumption and resulting CO2 emissions. Combining several existing technologies such as supercharging and variable valve actuation, downsizing is a typical example of the problems encountered in Spark Ignited (SI) engine control : nonlinear systems with saturation of actuators ; numerous major physica...

  6. Comment on “High-temperature soft magnetic properties of antiperovskite nitrides ZnNFe3 and AlNFe3” by Yankun Fu, Shuai Lin, and Bosen Wang, J. Magn. Magn. Mater. 378 (2015) 54–58

    Scholz, T.; Leineweber, A.; Dronskowski, R.

    2016-01-01

    The authors of the aforementioned manuscript have recently claimed the synthesis of the ternary nitrides ZnNFe 3 (=ZnFe 3 N) and AlNFe 3 (=AlFe 3 N), ordered substituted variants of the binary phase γ‘-Fe 4 N [1]. While soft ferromagnets of such kind are presently attracting lots of attention, their history dates back for more than half a century. In particular, Al-substituted γ‘-Fe 4 N has already been mentioned in 1961 [2], and the existence of AlFe 3 N has also been claimed in 2009 [3] from a two-step ammonolysis reaction combining a high-temperature sintering step and a low-temperature nitriding reaction [4]. Nonetheless, one of us had to withdraw the latter claim after finding out, by means of scanning-electron microscopy and elemental mapping, that all samples of “AlFe 3 N” consisted of an intimate solid mixture of γ‘-Fe 4 N and amorphous Al 2 O 3 [5]. From what follows, we have strong reasons to believe that the authors of Ref. [1] overlooked our findings [5] and also did not synthesize ZnFe 3 N and AlFe 3 N. - Highlights: • The synthesis of ZnFe 3 N and AlFe 3 N is questioned. • The diffraction data of ZnFe 3 N and AlFe 3 N resemble those of Fe 4 N. • The magnetic data of ZnFe 3 N and AlFe 3 N are compatible with those of Fe 4 N. • There is no physical evidence for the existence of ZnFe 3 N and AlFe 3 N.

  7. Association of the −243A>G, +61450C>A Polymorphisms of the Glutamate Decarboxylase 2 (GAD2) Gene with Obesity and Insu¬lin Level in North Indian Population

    Jai PRAKASH; Balraj MITTAL; Shally AWASTHI; Neena SRIVASTAVA

    2016-01-01

    Background: Obesity associated with type 2 diabetes, and hypertension increased mortality and morbidity. Glutamate decarboxylase 2 (GAD2) gene is associated with obesity and it regulate food intake and insulin level. We investigated the association of GAD-2gene −243A>G (rs2236418) and +61450C>A (rs992990) polymorphisms with obesity and related phenotypes.Methods: Insulin, glucose and lipid levels were estimated using standard protocols. All subjects were genotyped (PCR-RFLP) method.Resu...

  8. Multivariate Generalized Linear Mixed Models with High Complexity / Modèles linéaires généralisés mixtes multivariés avec complexité élevée

    Labouriau, Rodrigo

    . À titre d'exemple, je présenterai quelques applications à la génétique quantitative avec complexité élevée (plusieurs centaines de milliers d'observations et des pedigrees profonds). Dans toutes les applications présentées, il est essentiel de comprendre le processus stochastique sous-jacent associé...

  9. Conception, construction et essai d'un accélérateur linéaire à protons impulsé à 3 GHz (LIBO) pour la thérapie du cancer

    Berra, Paolo; De Conto, J M; Demeyer, A; Gerard, J P; Hoffmann, H F; Remillieux, J; Bajard, M; Rosso, E; Szeless, Balázs; Weiss, M

    2005-01-01

    In the last ten years the use of proton beams in radiation therapy has become a clinical tool for treatment of deep-seated tumours. LIBO is a RF compact and low cost proton linear accelerator (SCL type) for hadrontherapy. It is conceived by TERA Foundation as a 3 GHz Linac Booster, to be mounted downstream of an existing cyclotron in order to boost the energy of the proton beam up to 200 MeV, needed for deep treatment (~25 cm) in the human body. With this solution it is possible to transform a low energy commercial cyclotron, normally used for eye melanoma therapy, isotope production and nuclear physics research, into an accelerator for deep-seated tumours. A prototype module of LIBO has been built and successfully tested with full RF power at CERN and with proton beam at INFN Laboratori Nazionali del Sud (LNS) in Catania, within an international collaboration between TERA Foundation, CERN, the Universities and INFN groups of Milan and Naples. The mid-term aim of the project is the technology transfer of the ...

  10. Théorie de Perron-Frobenius non linéaire et méthodes numériques max-plus pour la résolution d'équations d'Hamilton-Jacobi

    Qu , Zheng

    2013-01-01

    Dynamic programming is one of the main approaches to solve optimal control problems. It reduces the latter problems to Hamilton-Jacobi partial differential equations (PDE). Several techniques have been proposed in the literature to solve these PDE. We mention, for example, finite difference schemes, the so-called discrete dynamic programming method or semi-Lagrangian method, or the antidiffusive schemes. All these methods are grid-based, i.e., they require a discretization of the state space,...

  11. Salvia officinalis (Lamiaceae) Lin. : caracterização química, atividade citotóxica e apoptótica em células de mamíferos

    Garcia, Charlene Silvestrin Celi

    2014-01-01

    Salvia officinalis (Lamiaceae), conhecida popularmente como sálvia, tem sido muito utilizada no sul do Brasil como condimento nos alimentos, tintura hidroalcoólica e chá para o tratamento de vários distúrbios de saúde. As propriedades dessa planta são estudadas por apontar possíveis mecanismos de ação antioxidante e antitumoral. Neste trabalho, o extrato hidroalcoólico e aquoso de sálvia foram analisados quimicamente por meio de cromatografia gasosa acoplada a espectrômetro de massas (GC-MS) ...

  12. Eestlastest tippjuhid kerge südamega võõrsile leiba teenima ei lähe / Mait Raava, Indrek Neivelt, Maive Rute ; interv. Tuuliki Kasonen-Lins

    Raava, Mait

    2006-01-01

    Pro Konsultatsioonide juhtimiskonsultant Mait Raava, Bank Saint Petersburgi nõukogu esimees Indrek Neivelt, Euroopa Komisjoni innovatsiooni ja väikeettevõtluse üksuse direktor Maive Rute vastavad küsimustele, mis puudutavad Eesti juhtide mainet ning töötamist välisriikides

  13. A Cross-Grade Study Validating the Evolutionary Pathway of Student Mental Models in Electric Circuits

    Lin, Jing-Wen

    2017-01-01

    Cross-grade studies are valuable for the development of sequential curriculum. However such studies are time and resource intensive and fail to provide a clear representation to integrate different levels of representational complexity. Lin (Lin, 2006; Lin & Chiu, 2006; Lin, Chiu, & Hsu, 2006) proposed a cladistics approach in conceptual…

  14. 75 FR 76648 - Proposed Establishment of Area Navigation (RNAV) Routes; Western United States

    2010-12-09

    ... routes would improve departure flow from the San Francisco/Oakland, CA, Terminal area by providing...'' N., long. 107[deg]55'30'' W.) * * * * * Q-128 LIN to MEM [New] LIN VORTAC (Lat. 38[deg]04'29'' N...'' W.) * * * * * Q-130 LIN to PNH [New] LIN VORTAC (Lat. 38[deg]04'29'' N., long. 121[deg]00'14'' W...

  15. 76 FR 13084 - Establishment of Area Navigation (RNAV) Routes; Western United States

    2011-03-10

    ... Francisco/Oakland, CA, Terminal area by providing additional parallel departure routings and improve arrival....) * * * * * * * Q-128 LIN to MEM [New] LIN VORTAC (Lat. 38[deg]04[min]29[sec] N., long. 121[deg]00[min]14[sec] W...] W.) * * * * * * * Q-130 LIN to PNH [New] LIN VORTAC (Lat. 38[deg]04[min]29[sec] N., long. 121[deg]00...

  16. Pramana – Journal of Physics | Indian Academy of Sciences

    Author Affiliations. Sheng Zhang1 2 Hong-Qing Zhang2. Department of Mathematics, Bohai University, Jinzhou 121013, People's Republic of China; School of Mathematical Sciences, Dalian University of Technology, Dalian 116024, People's Republic of China ...

  17. African Journal for the Psychological Study of Social Issues - Vol 9 ...

    Product's promotion patterns and their effects on consumers' purchase intentions, brand loyalty and attitude · EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. NA Shenge, 249-256 ...

  18. SUCCESS FACTORS OF A CHINESE RESTAURANT

    Xu, Peipei

    2012-01-01

    Abstract The thesis serves two main purposes. First, it aims to find out the factors that make the Chinese restaurant Dragon Sheng succeed. Second, its objective is to know customers’ satisfaction of Dragon Sheng. The comprehensive literature review traces the management in restaurant, brand building, service design, and customer relationship development. The primary data was collected through qualitative research method and personal interview were applied to collect information about...

  19. People’s Republic of China Scientific Abstracts No. 178

    1977-10-27

    of hepatic colls were observed by eleotron microscopy after carbon tetrachloride intoxication in mice . The hepatic cellular injuries were protected...administration in [continuation of SHENG-WU HUA-HSUEH YU SHENG-WU WU-LI-HSUEH-PAO Vol 8, No A, Dec 76 pp 333-340] mice . It is transformed from lipid...preparations for monopolizing the technique by capi- talist and revisionist countries. In a socialist country, the author claims, the purpose of developing

  20. Relationship between resistant hypertension and arterial stiffness assessed by brachial-ankle pulse wave velocity in the older patient

    Chung CM

    2014-09-01

    Full Text Available Chang-Min Chung,1,2 Hui-Wen Cheng,2 Jung-Jung Chang,2 Yu-Sheng Lin,2 Ju-Feng Hsiao,2 Shih-Tai Chang,1 Jen-Te Hsu2,31School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, 2Division of Cardiology, Chang Gung Memorial Hospital, Chiayi, 3Department of Medicine, College of Medicine, Chang Gung University, Taoyuan County, TaiwanBackground: Resistant hypertension (RH is a common clinical condition associated with increased cardiovascular mortality and morbidity in older patients. Several factors and conditions interfering with blood pressure (BP control, such as excess sodium intake, obesity, diabetes, older age, kidney disease, and certain identifiable causes of hypertension are common in patients resistant to antihypertensive treatment. Arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV, is increasingly recognized as an important prognostic index and potential therapeutic target in hypertensive patients. The aim of this study was to determine whether there is an association between RH and arterial stiffness. Methods: This study included 1,620 patients aged ≥65 years who were referred or self-referred to the outpatient hypertension unit located at a single cardiovascular center. They were separated into normotensive, controlled BP, and resistant hypertension groups. Home BP, blood laboratory parameters, echocardiographic studies and baPWV all were measured. Results: The likelihood of diabetes mellitus was significantly greater in the RH group than in the group with controlled BP (odds ratio 2.114, 95% confidence interval [CI] 1.194–3.744, P=0.010. Systolic BP was correlated in the RH group significantly more than in the group with controlled BP (odds ratio 1.032, 95% CI 1.012–1.053, P=0.001. baPWV (odds ratio 1.084, 95% CI 1.016–1.156, P=0.015 was significantly correlated with the presence of RH. The other factors were negatively correlated with the existence of RH.Conclusion: In

  1. Thermal properties and physicochemical behavior in aqueous solution of pyrene-labeled poly(ethylene glycol-polylactide conjugate

    Chen WL

    2015-04-01

    Full Text Available Wei-Lin Chen,1,2 Yun-Fen Peng,1,3 Sheng-Kuo Chiang,1 Ming-Hsi Huang1–3 1National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan; 2Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan; 3PhD Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University, Taichung, Taiwan Abstract: A fluorescence-labeled bioresorbable polymer was prepared by a coupling reaction of poly(ethylene glycol-polylactide (PEG-PLA with carboxyl pyrene, using N,N’-diisopropylcarbodiimide/1-hydroxy-7-azabenzotriazole (DIC/HOAt as a coupling agent and 4-dimethylaminopyridine (DMAP as a catalyst. The obtained copolymer, termed PEG-PLA-pyrene, was characterized using various analytical techniques, such as gel permeation chromatography (GPC, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS, proton nuclear magnetic resonance (1H-NMR, infrared spectroscopy (IR, differential scanning calorimetry (DSC, and thermogravimetric analysis (TGA, to identify the molecular structure and to monitor the thermal property changes before and after the reaction. The presence of a pyrene moiety at the end of polylactide (PLA did not alter the crystallization ability of the poly(ethylene glycol (PEG blocks, indicating that the conjugate preserved the inherent thermal properties of PEG-PLA. However, the presence of PEG-PLA blocks strongly reduced the melting of pyrene, indicating that the thermal characteristics were sensitive to PEG-PLA incorporation. Regarding the physicochemical behavior in aqueous solution, a higher concentration of PEG-PLA-pyrene resulted in a higher ultraviolet-visible (UV-vis absorbance and fluorescence emission intensity. This is of great interest for the use of this conjugate as a fluorescence probe to study the in vivo distribution as well as the internalization and intracellular localization of polymeric micelles

  2. Age-associated decrease in global DNA methylation in patients with major depression

    Tseng PT

    2014-11-01

    Full Text Available Ping-Tao Tseng,1,2,* Pao-Yen Lin,1,3,* Yu Lee,1 Chi-Fa Hung,1 For-Wey Lung,4,5 Cheng-Sheng Chen,6,7 Mian-Yoon Chong1 1Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; 2Department of Psychiatry, Tsyr-Huey Mental Hospital, Kaohsiung Jen-Ai’s Home, Taiwan; 3Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; 4Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan; 5Graduate Institute of Medical Science, National Defense Medical Center, Taipei, Taiwan; 6Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 7Department of Psychiatry, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan *These authors contributed equally to this work Background: Evidence has supported a role of DNA methylation in the pathophysiology of mood disorders. The purpose of the current study is to examine 5-methylcytosine (5-mc and 5-hydroxymethylcytosine (5-hmc levels in patients with major depressive disorder (MDD at different disease states.Methods: Forty-nine patients with MDD and 25 healthy control subjects were included. The severity in the disease was assessed by using the 17-item Hamilton Rating Scale of Depression (HAM-D (HAM-D ≥19 for severe MDD and HAM-D ≤7 for remitted MDD. The 5-mc and 5-hmc levels in leukocyte DNA were measured using an enzyme-linked immunosorbent assay-based method.Results: We found a significant decrease in 5-hmc and trends of decreasing 5-mc levels in patients with severe MDD compared to healthy controls (P=0.059 for 5-mc and P=0.013 for 5-hmc. The decrease in the level exists only in the older age group (P=0.035 for 5-mc and P=0.002 for 5-hmc but not in the younger age group (P=0.077 for 5-mc and P=0.620 for 5-hmc. In addition, the 5-mc level was found to be inversely correlated with disease severity (P=0.011.Conclusion: Our

  3. Anti-tumor effects of brucine immuno-nanoparticles on hepatocellular carcinoma

    Qin JM

    2012-01-01

    Full Text Available Jian-Min Qin1, Pei-Hao Yin1, Qi Li1, Zhong-Qiu Sa1, Xia Sheng1, Lin Yang1, Tao Huang1, Min Zhang1, Ke-Pan Gao2, Qing-Hua Chen2, Jing-Wei Ma3, He-Bai Shen31Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, 2National Pharmaceutical Engineering Research Center; Shanghai Institute of Pharmaceutical Industry, 3Department of Physical Chemistry, Shanghai Normal University, Shanghai, People's Republic of ChinaBackground: Hepatocellular carcinoma is difficult to diagnose early, and most patients are already in the late stages of the disease when they are admitted to hospital. The total 5-year survival rate is less than 5%. Recent studies have showed that brucine has a good anti-tumor effect, but high toxicity, poor water solubility, short half-life, narrow therapeutic window, and a toxic dose that is close to the therapeutic dose, which all limit its clinical application. This study evaluated the effects of brucine immuno-nanoparticles (BIN on hepatocellular carcinoma.Materials and methods: Anionic polymerization, chemical modification technology, and phacoemulsification technology were used to prepare a carboxylated polyethylene glycol-polylactic acid copolymer carrier material. Chemical coupling technology was utilized to develop anti-human AFP McAb-polyethylene glycol-polylactic acid copolymer BIN. The size, shape, zeta potential, drug loading, encapsulation efficiency, and release of these immune-nanoparticles were studied in vitro. The targeting, and growth, invasion, and metastasis inhibitory effects of this treatment on liver cancer SMMC-7721 cells were tested.Results: BIN were of uniform size with an average particle size of 249 ± 77 nm and zeta potential of -18.7 ± 4.19 mV. The encapsulation efficiency was 76.0% ± 2.3% and the drug load was 5.6% ± 0.2%. Complete uptake and even distribution around the liver cancer cell membrane were observed.Conclusion: BIN had even size distribution, was

  4. Neuroprotection of lamotrigine on hypoxic-ischemic brain damage in neonatal rats: Relations to administration time and doses

    Yong-Hong Yi

    2008-06-01

    Full Text Available Yong-Hong Yi1, Wen-Chao Guo1, Wei-Wen Sun1, Tao Su1, Han Lin1, Sheng-Qiang Chen1, Wen-Yi Deng1, Wei Zhou2, Wei-Ping Liao11Department of Neurology, Institute of Neurosciences and the Second Affiliated Hospital, 2Department of Neonatology, Affiliated Guangzhou Children’s Hospital, Guangzhou Medical College, Guangzhou, Guangdong Province, P.R. ChinaAbstract: Lamotrigine (LTG, an antiepileptic drug, has been shown to be able to improve cerebral ischemic damage by limiting the presynaptic release of glutamate. The present study investigated further the neuroprotective effect of LTG on hypoxic-ischemic brain damage (HIBD in neonatal rats and its relations to administration time and doses. The HIBD model was produced in 7-days old SD rats by left common carotid artery ligation followed by 2 h hypoxic exposure (8% oxygen. LTG was administered intraperitoneally with the doses of 5, 10, 20, and 40 mg/kg 3 h after operation and the dose of 20 mg/kg 1 h before and 3 h, 6 h after operation. Blood and brain were sampled 24 h after operation. Nissl staining, terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL, and neuron-specific enolase (NSE immunohistochemical staining were used for morphological studies. Water content in left cortex and NSE concentration in serum were determined. LTG significantly reduced water content in the cerebral cortex, as well as the number of TUNEL staining neurons in the dentate gyrus and cortex in hypoxic-ischemia (HI model. Furthermore, LTG significantly decreased the NSE level in serum and increased the number of NSE staining neurons in the cortex. These effects, except that on water content, were dose-dependent and were more remarkable in the pre-treated group than in the post-treated groups. These results demonstrate that LTG may have a neuroprotective effect on acute HIBD in neonates. The effect is more prominent when administrated with higher doses and before HI.Keywords: hypoxic-ischemic brain

  5. Upregulation of vascular endothelial growth factor receptor-1 contributes to sevoflurane preconditioning–mediated cardioprotection

    Qian B

    2018-04-01

    Full Text Available Bin Qian,1 Yang Yang,2 Yusheng Yao,3 Yanling Liao,3 Ying Lin3 1Department of Anesthesiology, People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China; 2Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China; 3Department of Anesthesiology, The Shengli Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, China Purpose: Sevoflurane preconditioning (SPC can provide myocardial protective effects similar to ischemic preconditioning. However, the exact mechanism of SPC remains unclear. Previous studies indicate that vascular endothelial growth factor receptor 1 (VEGFR-1 is involved in ischemic preconditioning-mediated cardioprotection. This study was designed to determine the significance of VEGFR-1 signaling in SPC-mediated cardioprotection.Materials and methods: Myocardial ischemia–reperfusion (I/R rat model was established using the Langendorff isolated heart perfusion apparatus. Additionally, after 15 min of baseline equilibration, the isolated hearts were pretreated with 2.5% sevoflurane, 2.5% sevoflurane+MF1 10 µmol/L, or 2.5% sevoflurane+placental growth factor 10 µmol/L, and then subjected to 30 min of global ischemia and 120 min of reperfusion. The changes in hemodynamic parameters, myocardial infarct size, and the levels of creatine kinase-MB, lactate dehydrogenase, cardiac troponin-I, tumor necrosis factor-α, and interleukin 6 in the myocardium were evaluated.Results: Compared to the I/R group, pretreatment with 2.5% sevoflurane significantly improved the cardiac function, limited myocardial infarct size, reduced cardiac enzyme release, upregulated VEGFR-1 expression, and decreased inflammation. In addition, the selective VEGFR-1 agonist, placental growth factor, did not enhance the cardioprotection and anti-inflammation effects of sevoflurane, while the specific VEGFR-1 inhibitor, MF1, completely reversed these effects

  6. Cinderella's Lessons on Footbinding: How Tiny Feet Found their Way into the Chinese Cinderella Story

    Tyler Scott Smith

    2013-05-01

    Full Text Available The story of Cinderella has had many variants, some dating back to ancient Tibetan trade routes and dynastic China. When the tale is analysed in comparison to other variants it is found that in the Chinese version Yeh-Shen (Cinderella is prized for the small size of her feet. The result of Yeh-Shen having small feet in the story is that she is led her into wealth, power and marriage, the same pursuable goals that led to the custom of footbinding. In southern China the custom of footbinding became a historically defining feature of the society. A women's beauty and her delicacy were judged by the size of her feet, and small feet were the aim of the binding. Small feet played such an important role in the society that it can be found as early as the ninth century C.E., in the traditional oral story, Yeh-Shen.

  7. An Improvement on Remote User Authentication Schemes Using Smart Cards

    Chin-Ling Chen

    2018-01-01

    Full Text Available In 2010, Yeh et al. proposed two robust remote user authentication schemes using smart cards; their claims were such that their schemes defended against ID-theft attacks, reply attacks, undetectable on-line password guessing attacks, off-line password guessing attacks, user impersonation attack, server counterfeit attack and man-in-the-middle attack. In this paper, we show that Yeh et al.’s schemes are still vulnerable to ID-theft attack, off-line password guessing attacks, undetectable on-line password guessing attacks and user impersonation attack. Notably, problems remain in situations where the user lost a smart card or the malicious legal user. To remedy these flaws, this paper proposes an improvement on Yeh et al.’s remote user authentication schemes using smart cards.

  8. PREFACE: Preface

    Ye, Chaohui; Wang, Zhong Lin; Zhou, Bingkun

    2011-02-01

    , Tsinghua University (China)X C Zhang, Rensselaer Polytechnic Institute (USA) Program Committee:Qingming Luo, Wuhan National Laboratory for Optoelectronics (China) - ChairHiroshi Amano, Meijo University (Japan)Yibing Cheng, Monash University (Australia)Peixiang Lu, Wuhan National Laboratory for Optoelectronics (China)Ruxin Li, Shanghai Institute of Optics and Fine Mechanics (China)Chinlon Lin, Bell Laboratory (USA)Xun Li, McMaster University (Canada)Shenggang Liu, University of Electronic Science and Technology of China (China)Katsumi Midorikawa, Extreme Photonics Research Group, RIKEN (Japan)Jesper Moerk, Technical University of Denmark (Denmark)Valery V Tuchin, Saratov State University (Russia)Lihong Wang, Washington University in St. Louis (USA)Zhong Lin Wang, Georgia Institute of Technology(USA)Jinzhong Yu, Institute of Semiconductor, CAS (China)Jianquan Yao, Tianjin University (China)X C Zhang, Rensselaer Polytechnic Institute (USA) Local Organizing committee:Lin Lin, Wuhan National Laboratory for Optoelectronics (China) - ChairSheng Lu, Administration Committee of Wuhan East Lake Hi-tech Development Zone (China) - ChairChangqing Chen, Wuhan National Laboratory for Optoelectronics (China)Ling Fu, Wuhan National Laboratory for Optoelectronics (China)Hongwei Han, Wuhan National Laboratory for Optoelectronics (China)Peixiang Lu, Wuhan National Laboratory for Optoelectronics (China)Pengcheng Li, Wuhan National Laboratory for Optoelectronics (China)Jinsong Liu, Wuhan National Laboratory for Optoelectronics (China)Junqiang Sun, Wuhan National Laboratory for Optoelectronics (China)Guozhen Shen, Wuhan National Laboratory for Optoelectronics (China)Guoli Tu, Wuhan National Laboratory for Optoelectronics (China)Kecheng Yang, Wuhan National Laboratory for Optoelectronics (China)Xinliang Zhang, Wuhan National Laboratory for Optoelectronics (China)Yuandi Zhao, Wuhan National Laboratory for Optoelectronics (China) Local Secretariat:Xiaochun Xiao, Huazhong University of Science and

  9. Cinderella's Lessons on Footbinding: How Tiny Feet Found their Way into the Chinese Cinderella Story

    Tyler Scott Smith

    2013-01-01

    The story of Cinderella has had many variants, some dating back to ancient Tibetan trade routes and dynastic China. When the tale is analysed in comparison to other variants it is found that in the Chinese version Yeh-Shen (Cinderella) is prized for the small size of her feet. The result of Yeh-Shen having small feet in the story is that she is led her into wealth, power and marriage, the same pursuable goals that led to the custom of footbinding. In southern China the custom of footbinding b...

  10. Cisplatin induces protective autophagy through activation of BECN1 in human bladder cancer cells

    Lin JF

    2017-05-01

    Full Text Available Ji-Fan Lin,1 Yi-Chia Lin,2 Te-Fu Tsai,2,3 Hung-En Chen,2 Kuang-Yu Chou,2,3 Thomas I-Sheng Hwang2–4 1Central Laboratory, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, 2Division of Urology, School of Medicine, Fu-Jen Catholic University, New Taipei, 3Division of Urology, Department of Surgery, Shin Kong Wu Ho-Su Memorial Hospital, 4Department of Urology, Taipei Medical University, Taipei, Taiwan Purpose: Cisplatin-based chemotherapy is the first line treatment for several cancers including bladder cancer (BC. Autophagy induction has been implied to contribute to cisplatin resistance in ovarian cancer; and a high basal level of autophagy has been demonstrated in human bladder tumors. Therefore, it is reasonable to speculate that autophagy may account for the failure of cisplatin single treatment in BC. This study investigated whether cisplatin induces autophagy and the mechanism involved using human BC cell lines.Materials and methods: Human BC cells (5637 and T24 were used in this study. Cell viability was detected using water soluble tetrazolium-8 reagents. Autophagy induction was detected by monitoring the levels of light chain 3 (LC3-II and p62 by Western blot, LC3-positive puncta formation by immunofluorescence, and direct observation of the autophagolysosome (AL formation by transmission electron microscopy. Inhibitors including bafilomycin A1 (Baf A1, chloroquine (CQ, and shRNA-based lentivirus against autophagy-related genes (ATG7 and ATG12 were utilized. Apoptosis level was detected by caspase 3/7 activity and DNA fragmentation.Results: Cisplatin decreased cell viability and induced apoptosis of 5637 and T24 cells in a dose- and time-dependent manner. The increased LC3-II accumulation, p62 clearance, the number of LC3-positive puncta, and ALs in cisplatin-treated cells suggested that cisplatin indeed induces autophagy. Inhibition of cisplatin-induced autophagy using Baf A1, CQ, or ATG7/ATG12 shRNAs significantly enhanced cytotoxicity of

  11. Conserved ABC Transport System Regulated by the General Stress Response Pathways of Alpha- and Gammaproteobacteria

    Herrou, Julien; Willett, Jonathan W.; Czy; #380; , Daniel M.; Babnigg, Gyorgy; Kim, Youngchang; Crosson, Sean (UC)

    2016-12-19

    ABSTRACT

    Brucella abortusσE1is an EcfG family sigma factor that regulates the transcription of dozens of genes in response to diverse stress conditions and is required for maintenance of chronic infection in a mouse model. A putative ATP-binding cassette transporter operon,bab1_0223-bab1_0226, is among the most highly activated gene sets in the σE1regulon. The proteins encoded by the operon resemble quaternary ammonium-compatible solute importers but are most similar in sequence to the broadly conserved YehZYXW system, which remains largely uncharacterized. Transcription ofyehZYXWis activated by the general stress sigma factor σSinEnterobacteriaceae, which suggests a functional role for this transport system in bacterial stress response across the classesAlphaproteobacteriaandGammaproteobacteria. We present evidence thatB. abortusYehZYXW does not function as an importer of known compatible solutes under physiological conditions and does not contribute to the virulence defect of a σE1-null strain. The solein vitrophenotype associated with genetic disruption of this putative transport system is reduced growth in the presence of high Li+ion concentrations. A crystal structure ofB. abortusYehZ revealed a class II periplasmic binding protein fold with significant structural homology toArchaeoglobus fulgidusProX, which binds glycine betaine. However, the structure

  12. Allozyme variation in Picea mariana from Newfoundland: Discussion

    William B. Critchfield

    1987-01-01

    In their recent paper describing the distribution of genetic variation in black spruce (Picea mariana (Mill.) B.S.P.) on the island of Newfoundland, Yeh et el. (1986) concluded that a center of variability in west-central Newfoundland derived from ancestral populations that persisted on the island during the last (Wisconsin) glaciation. They...

  13. Author Details - AJOL

    Yeh-Gorocica, A. Vol 6, No 1 (2016) - Articles First molecular evidence of Toxoplasma gondii in opossums (Didelphis virginiana) from Yucatan, Mexico Abstract PDF. ISSN: 2218-6050. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

  14. A generalized solution for groundwater head fluctuation in a tidal ...

    Mo-Hsiung Chuang1 and Hund-Der Yeh2,∗. 1Department of Urban Planning and Disaster Management, Ming-Chuan University,. Gweishan District, Taoyuan, Taiwan. 2Institute of Environmental Engineering, National Chiao Tung University, Hsinchu, Taiwan. ∗. Corresponding author. e-mail: hdyeh@mail.nctu.edu.tw.

  15. Exploitation, exploration, and how learning affects strategic intent in multinational enterprises' foreign direct investment decisions: A commentary essay

    Kamal, F.; Englis-Danskin, Paula

    2012-01-01

    Research on foreign direct investment is a rich vein of inquiry in international business and management literature. Scholars explore various aspects of FDI including the reasons for location selection. Chen and Yeh's research is in that tradition. Under the title of “Re-examining location

  16. Zhou et al., Afr J Tradit Complement Altern Med. (2015) 12(4):87-95 ...

    Proff.Adewunmi

    containing 10 rats: (1) I/R-ethanol group (IRI), in which the rats were .... Wy14643 Pretreatment Alleviated Liver Pathological Changes in Liver I/R Injury .... IRI in myocardial and cerebral by suppressing inflammation(Yeh CH,2006; Collino M,.

  17. photoautotrophic, photomixotrophic

    Dion Daniels

    on the adaptation of papaya plants, strengthening the function of the stomata and with this, allowing .... culture vessels with a total volume of 250 mL with 30 mL of liquid ..... scaling. Physiological parameters: Chlorophyll a, b and carotenoids. In terms ..... Soluble sugars mediate .... Yu TA, Yeh SD, Cheng YH, Yang JS (2000).

  18. Mental Health Help-Seeking Behaviors among Asian American Community College Students: The Effect of Stigma, Cultural Barriers, and Acculturation

    Han, Meekyung; Pong, Helen

    2015-01-01

    According to the 2008 U.S. Census, there are 15.5 million Asian Americans in the United States, and 17% are students enrolled in a university (Shea & Yeh, 2008). Asian American college students in higher education are oftentimes perceived as the "model minority" with high academic achievements and few mental and/or behavioral…

  19. How Many Women Are Affected by or at Risk of Preeclampsia?

    ... pregnancy outcomes: Differences among 4 racial/ethnic groups. American Journal of Public Health, 95 (9), 1545–1551. Lin, H. C., Chen, S. F., Lin, H. C., & Chen, Y. H. (2010). Increased risk of adverse pregnancy outcomes ...

  20. Depression and family support in breast cancer patients

    Su JA

    2017-09-01

    Full Text Available Jian-An Su,1–3,* Dah-Cherng Yeh,4,* Ching-Chi Chang,5,* Tzu-Chin Lin,6,7 Ching-Hsiang Lai,8 Pei-Yun Hu,8 Yi-Feng Ho,9 Vincent Chin-Hung Chen,1,2 Tsu-Nai Wang,10,11 Michael Gossop12 1Chang Gung Medical Foundation, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan; 2Department of Medicine, School of Medicine, Chang Gung University, Taoyuan, Taiwan; 3Department of Nursing, Chang Gung Institute of Technology, Taoyuan, Taiwan; 4Department of Surgery, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan; 5Institute of Medicine, Chung Shan Medical University and Department of Psychiatry, Chung Shan Medical University Hospital, Taichung, Taiwan; 6Department of Psychiatry, Chung Shan Medical University Hospital, Taichung, Taiwan; 7Department of Psychiatry, School of Medicine, Chung Shan Medical University, Taichung, Taiwan; 8Department of Medical Informatics, Chung Shan Medical University, Taichung, Taiwan; 9Tsaotun Psychiatric Center, Ministry of Health and Welfare, Nan-Tou,Taiwan; 10Department of Public Health, College of Health Science, Kaohsiung Medical University, Kaohsiung, Taiwan; 11Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 12King’s College London, Institute of Psychiatry, London, UK *These authors contributed equally to this work Background: Breast cancer is the most common cancer in women. Among the survivors, depression is one of the most common psychiatric comorbidities. This paper reports the point prevalence of major depressive disorder among breast cancer patients and the association between family support and major depressive disorder.Methods: Clinical data were collected from a breast cancer clinic of a general hospital in central Taiwan. Participants included 300 patients who were older than 18 years and diagnosed with breast cancer. Among these individuals, we used Mini International Neuropsychiatric Interview (a structural diagnostic tool for

  1. Tobacco-Smoking, Alcohol-Drinking, and Betel-Quid-Chewing Behaviors: Development and Use of a Web-Based Survey System.

    Hsu, Kuo-Yao; Tsai, Yun-Fang; Huang, Chu-Ching; Yeh, Wen-Ling; Chang, Kai-Ping; Lin, Chen-Chun; Chen, Ching-Yen; Lee, Hsiu-Lan

    2018-06-11

    family members or friends took 7.7 minutes (SD 2.8; range 3-18). Most of the participants completed the survey within 5-10 minutes. The Web-based survey was easy to self-administer. Health care providers can use this Web-based survey system to save time in assessing these risk behaviors in clinical settings. All smokers had mild-to-severe nicotine addiction, and 5.6%-12.3% of patients and their family members or friends were at risk of alcohol dependence. Considering that these three behaviors, particularly in combination, dramatically increase the risk of esophageal cancer, appropriate and convenient interventions are necessary for preserving public health in Taiwan. ©Kuo-Yao Hsu, Yun-Fang Tsai, Chu-Ching Huang, Wen-Ling Yeh, Kai-Ping Chang, Chen-Chun Lin, Ching-Yen Chen, Hsiu-Lan Lee. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 11.06.2018.

  2. Design of acid-responsive polymeric nanoparticles for 7,3',4'-trihydroxyisoflavone topical administration

    Huang PH

    2016-04-01

    Full Text Available Pao-Hsien Huang,1,* Stephen Chu-Sung Hu,2,3,* Chiang-Wen Lee,4,5 An-Chi Yeh,6 Chih-Hua Tseng,7 Feng-Lin Yen1,8,9 1Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, 2Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, 3Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung, 4Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Kweishan, Taoyuan, 5Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chia-Yi, 6Department of Cosmetics and Fashion Styling, Cheng Shiu University, Kaohsiung, 7School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, 8Lipid Science and Aging Research Center, Kaohsiung Medical University, Kaohsiung, 9Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan *These authors contributed equally to this work Abstract: 7,3',4'-Trihydroxyisoflavone (734THIF is a secondary metabolite of daidzein and has been recently found to possess antioxidant, melanin inhibition, and skin cancer chemopreventive activities. However, the poor water solubility of 734THIF impedes its absorption and skin penetration and, therefore, limits its pharmacological effects when applied topically to the skin. We seek to use the nanoprecipitation method to prepare optimal eudragit E100 (EE–polyvinyl alcohol (PVA-loaded 734THIF nanoparticles (734N to improve its physicochemical properties and thereby increase its water solubility, skin penetration, and biological activities. EE–PVA-loaded 734THIF nanoparticles (734N were prepared, and their morphology and particle size were evaluated using a particle size analyzer and by electron microscopy. The drug loading and encapsulation efficiencies and in vitro solubility were determined using high-performance liquid chromatography. Hydrogen

  3. Renal targeting potential of a polymeric drug carrier, poly-L-glutamic acid, in normal and diabetic rats

    Chai HJ

    2017-01-01

    Full Text Available Hann-Juang Chai,1 Lik-Voon Kiew,1 Yunni Chin,1 Anwar Norazit,2 Suzita Mohd Noor,2 Yoke-Lin Lo,3,4 Chung-Yeng Looi,1 Yeh-Siang Lau,1 Tuck-Meng Lim,5 Won-Fen Wong,6 Nor Azizan Abdullah,1 Munavvar Zubaid Abdul Sattar,7 Edward J Johns,8 Zamri Chik,1 Lip-Yong Chung3 1Department of Pharmacology, 2Department of Biomedical Science, 3Department of Pharmacy, Faculty of Medicine, University of Malaya, 4School of Pharmacy, International Medical University, Kuala Lumpur, 5Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar, 6Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, 7School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Malaysia; 8Department of Physiology, University College Cork, Cork, Republic of Ireland Background and purpose: Poly-L-glutamic acid (PG has been used widely as a carrier to deliver anticancer chemotherapeutics. This study evaluates PG as a selective renal drug carrier.Experimental approach: 3H-deoxycytidine-labeled PGs (17 or 41 kDa and 3H-deoxycytidine were administered intravenously to normal rats and streptozotocin-induced diabetic rats. The biodistribution of these compounds was determined over 24 h. Accumulation of PG in normal kidneys was also tracked using 5-(aminoacetamido fluorescein (fluoresceinyl glycine amide-labeled PG (PG-AF. To evaluate the potential of PGs in ferrying renal protective anti-oxidative stress compounds, the model drug 4-(2-aminoethylbenzenesulfonyl fluoride hydrochloride (AEBSF was conjugated to 41 kDa PG to form PG-AEBSF. PG-AEBSF was then characterized and evaluated for intracellular anti-oxidative stress efficacy (relative to free AEBSF.Results: In the normal rat kidneys, 17 kDa radiolabeled PG (PG-Tr presents a 7-fold higher, while 41 kDa PG-Tr shows a 15-fold higher renal accumulation than the free radiolabel after 24 h post injection. The accumulation of PG-AF was primarily found in the renal tubular

  4. Therapeutic effects of Laser and L-carnitine against amiodarone ...

    Pulmonary toxicity is considered a life- threatening complication of ... Research Center, Faculty of Medicine, Ain .... Laser therapy restores the balance between oxidants and ... No conflict of interest associated with this work. Contribution of .... Fitness. 2014; 149-159. 21. Lee BJ, Lin JS, Lin YC, Lin PT. Effects of L-carnitine.

  5. Acoustic Analyses of the Singing Vibrato in Traditional Peking Opera.

    Han, Qichao; Zhang, Ruifeng

    2017-07-01

    China's traditional Peking Opera has four standard categories of roles: Sheng, Dan, Jing, and Chou, the singing vibrato of each displaying a different auditory effect. The audio and respiratory signals were recorded for two performers of the Qing Yi role, one of the Jing role, one of the Chou role, one of the Lao Sheng role, one of the Xiao Sheng role, and one of the Lao Dan role. The recordings gained eventually consisted of 24 representative songs from six roles. The rates and extents of vibrato, fundamental frequency, and rib cage signals were analyzed. Two findings were obtained: (1) the classical opera singing vibratos of China and Western countries are acoustically different from each other; and (2) in Peking Opera, the singing vibratos of different roles show significant acoustic differences. Copyright © 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  6. iPS-Cinderella Story in Cell Biology

    Editorial

    2010-01-01

    Full Text Available As we step through the frontiers of modern Science, we are all witnesses to the Cinderella story repeating itself in the form of the iPS. The process of re-programming adult somatic cells to derive Induced Pluripotent stem cells (iPS with the wand of transcription factors and then differentiating them back to adult somatic cells resembles the transformation of Cinderella from a Cinder girl to princess and back to a Cinder girl after the ball; but the iPS-Cinderella is the most fascinating thing ever in cell biology!From the day iPS first made its headlines when it was first produced by Shinya Yamanaka at Kyoto University in Japan, Stem Cell scientists all over the world are re- doing their experiments so far done using other sources like embryonic and adult Stem cells with the iPS cells exploring their potential to the fullest. A Stem Cell science news page without this magic word of iPS is difficult to imagine these days and Scientists have been successful in growing most of the adult Cell types from iPS cells.iPS cells was the key to solve the problems of Immune rejection and Immunosupression required when using other allogeneic Stem cell types which had baffled scientists previously. But the issues raised by scientists about the use of viruses and Oncogenes in producing iPS cells were made groundless when scientists in February 2008 published the discovery of a technique that could remove oncogenes after the induction of pluripotency and now it is possible to induce pluripotency using plasmid transfection, piggyback transposon system and piggyback transposon system combined with a non viral vector system. The word of the day is pIPS which are protein-induced Pluripotent stem cells which are iPS cells that were generated without any genetic alteration of the adult cell. This research by the group of Sheng Ding in La Jolla, California made public in April 2009 showed that the generation of poly-arginine anchors was sufficient to induce

  7. Potential role of pre- and postnatal testosterone levels in attention-deficit/hyperactivity disorder: is there a sex difference?

    Wang LJ

    2017-05-01

    Full Text Available Liang-Jen Wang,1,2 Miao-Chun Chou,1 Wen-Jiun Chou,1 Min-Jing Lee,1 Sheng-Yu Lee,3,4 Pao-Yen Lin,5 Yi-Hsuan Lee,1 Yi-Hsin Yang,6 Cheng-Fang Yen2,7 1Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 2Department of Psychiatry, School of Medicine, and Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, 3Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, 4Department of Psychiatry, College of Medicine and Hospital, National Cheng Kung University, Tainan, 5Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 6School of Pharmacy, Kaohsiung Medical University Hospital, 7Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan Objective: Both prenatal testosterone (T exposure and postnatal T levels have been associated with developing neural circuitry and behavioral systems. This study examined the potential correlation between pre- and postnatal T levels and behavioral and neurocognitive profiles of children with attention-deficit/hyperactivity disorder (ADHD.Methods: Two hundred ADHD patients with a mean age of 8.7±2.0 years (158 boys and 42 girls were recruited. The ratio of the length of the right index finger (2D to that of the right ring finger (4D (2D/4D ratio served as a surrogate of prenatal T exposure, and postnatal T was determined using salivary T concentration. Behavioral symptoms were evaluated using the Swanson, Nolan, and Pelham – Version IV Scale for ADHD (SNAP-IV. Neurocognitive function was assessed using the Wechsler Intelligence Scale for Children – Fourth Edition (WISC-IV and Conners’ Continuous Performance Test (CPT.Results: Lower 2D/4D ratios were associated with comorbid disruptive behavior disorders (t=2.15, P=0.033 in all participants. Among the boys with ADHD, neither 2D/4D ratios nor salivary T levels

  8. Intelligence quotient discrepancy indicates levels of motor competence in preschool children at risk for developmental delays

    Yu TY

    2016-02-01

    Full Text Available Tzu-Ying Yu,1 Kuan-Lin Chen,2,3 Willy Chou,4,5 Shu-Han Yang,4 Sheng-Chun Kung,4 Ya-Chen Lee,2 Li-Chen Tung4,6,7 1Department of Occupational Therapy, College of Medicine, I-Shou University, Kaohsiung, 2Department of Occupational Therapy, College of Medicine, National Cheng Kung University, Tainan, 3Department of Physical Medicine and Rehabilitation, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 4Department of Physical Medicine and Rehabilitation, Chi-Mei Medical Center, Tainan, 5Department of Recreation and Health Care Management, Cha Nan University of Pharmacy and Science, Tainan, 6School of Medicine, Kaohsiung Medical University, Kaohsiung, 7School of Medicine, Chung Shan Medical University, Taichung, Taiwan Purpose: This study aimed to establish 1 whether a group difference exists in the motor competence of preschool children at risk for developmental delays with intelligence quotient discrepancy (IQD; refers to difference between verbal intelligence quotient [VIQ] and performance intelligence quotient [PIQ] and 2 whether an association exists between IQD and motor competence.Methods: Children’s motor competence and IQD were determined with the motor subtests of the Comprehensive Developmental Inventory for Infants and Toddlers and Wechsler Preschool and Primary Scale of Intelligence™ – Fourth Edition. A total of 291 children were included in three groups: NON-IQD (n=213; IQD within 1 standard deviation [SD], VIQ>PIQ (n=39; VIQ>PIQ greater than 1 SD, and PIQ>VIQ (n=39; PIQ>VIQ greater than 1 SD.Results: The results of one-way analysis of variance indicated significant differences among the subgroups for the “Gross and fine motor” subdomains of the Comprehensive Developmental Inventory for Infants and Toddlers, especially on the subtests of “body-movement coordination” (F=3.87, P<0.05 and “visual-motor coordination” (F=6.90, P<0.05. Motor competence was significantly

  9. 專論/論搜尋引擎以程式在網路上自動抓取資料時可能面臨之法律問題及其解決之道/廖先志;陳鍾誠 | The Possible Legal Issues about Crawlers and Their Resolutions/ Hsien-Jyh Liao;Yi-Hsuan Lin

    廖先志、陳鍾誠

    2007-04-01

    Full Text Available

    搜尋引擎必須以Crawler程式(又稱spider程式)來自動抓取網頁並建立索引,如果Crawler程式僅僅循著網頁所提供的超連結來搜尋網 頁並抓取內容,稱為一般性的Crawler程式:如果不論網頁是否提供超連結,Crawler程式會自行計算並找到網頁的所有內容並加以抓取,此種 Crawler則稱為深度Crawler。而Crawler抓取網頁內容的步驟可以細分為「取得資料」及「儲存並建立索引」二大步驟。在「取得資料」階段 中,深度Crawler雖然是自行透過演算法來取得網頁的所有內容,但本文認為仍不至於構成非法存取(unauthorized access。此外,不論是一般的Crawler或是深度Crawler,如果取得網頁內容時會耗費網站資源而干擾網站的正常運作,就可能構成如美國 eBdy案中討論的財產侵害(trespass to chattel。在「儲存並建立索引」階段中,原則上應該不會侵害網頁擁有者之重製權,然而、有些搜尋引擎(例如Google將其取得的內容以「庫存 頁面」( Cache的方式允許使用者存取,此時即有爭議發生,但本文以為,由於搜尋引擎的主要目的是在使網路使用者更容易接觸網頁,所以此種「重製」與「散布」 行為原則上應有著作權法「合理使用」原則的適用,故不會構成侵害著作權,但仍應考慮搜尋引擎與原網站之間是否處於競爭關係,以及所抓取之資料量佔原網站之 比例等因素綜合判斷。要解決搜尋引擎與網站間可能發生的法律爭議,除可以強化現行的robot exclusion標準外,網站也可以考慮增強自動過濾Crawler的功能,以杜絕爭議。


    A Search engine uses a crawler (or a spider to retrieve and index web pages. A “general crawler” crawls across the Internet by following only the hyperlinks directly provided by web pages. On the other hand, a “deep crawler” has the capability of retrieving all contents of web pages whether the hyperlinks are available or not. The process of a crawler’s work can be split into two major steps: the “retrieving” step and the “storage and indexing” step. As far as the retrieving step is concerned, even though a deep crawler can generate all URLs by itself, there should not be any unauthorized access at all. However, a crawler, either a general or deep one, will be charged with trespassing to chattel if it interferes in the website, whereas, in the “storage and indexing” step, owners’ copyright of web pages will in principle not be infringed upon by a crawler. Nevertheless, there are controversies about “cache”, which is provided by certain popular search engines, such as Google and Yahoo. Search engines may claim their fair use defense of “cache”, because one of the main goals of search engines is to improve access to information on the internet. Actually, we must consider many factors before we decide whether “cache” is fair or not, for instance, whether there is competition between the search engine and the retrieved web sites; and what percentage of the contents is retrieved by the crawler, etc. To resolve all possible legal conflicts between crawlers and web pages, among several economic resolutions, a newer and complete robot exclusion standard is required. In addition, a self-detecting mechanism adopted by web pages may be even a more powerful one.

    頁次:53-66

  10. Stages of maturation of the fruit on germination and oil content in seeds of Jatropha curcas LinEstádios de maturação do fruto no desempenho germinativo e teor de óleo de sementes de Jatropha curcas Linn

    Fernanda Rubio

    2013-05-01

    Full Text Available Jatropha curcas Linn., known as physic nut, is a plant that has oil content between 35 and 38%, being used as an alternative for producing biodiesel. However, this culture has uneven fruiting, which discourages the harvest period. This study aimed to relate the color of the seeds during fruit maturation and germination characteristics with the oil concentration, confirming the best time for harvest. Using the Munsell color chart the seeds were classified into four stages: VC (light seeds of unripe fruits, VE (dark seeds of unripe fruits, A (seeds of fruits attached to the tree and C (seeds to the ground. It was conducted the germination test, moisture, dry matter and oil content. The seeds of fruits that were attached to the tree (level A obtained better results in test of germination, about 25% because they had higher dry matter (90.51% and lower water content (9.49%. They also had the largest concentration of oil, which was 47.36% (almond, and therefore, the best stage for harvesting. The light seeds of unripe fruits (VC, did not obtain satisfactory germination (1.25%, indicating that the color of the fruits can be a parameter for physiological maturity of Jatropha curcas Linn.Jatropha curcas Linn. conhecido como pinhão manso apresenta teor de óleo entre 35 e 38% em suas sementes, sendo utilizado como alternativa na produção de biodiesel. Porém, essa cultura apresenta frutificação desuniforme, o que desfavorece a determinação do período ideal de colheita. Desta forma, esse trabalho objetivou relacionar a coloração das sementes de Jatropha curcas Linn. durante o processo de maturação dos frutos com as características germinativas e concentração de óleo, verificando assim a melhor época para a colheita. Utilizando a carta de cores de Munsell, as sementes foram classificadas em 4 estádios: VC (sementes claras de frutos verdes, VE (sementes escuras de frutos verdes, A (sementes de frutos maduros presos à árvore e C (sementes ao chão. Foi realizado o teste de germinação, umidade, matéria seca e teor de óleo das sementes. As sementes dos frutos secos presos à árvore (estádio A resultaram em maior germinação, cerca de 25%, pois possuíam maior massa seca (90.51% e menor teor de água (9.49%. No estádio A as sementes apresentaram também a maior concentração de óleo, que foi de 47.36% (amêndoa, sendo, portanto, o estádio mais indicado para a colheita dos frutos. As sementes claras de frutos verdes (VC, não apresentaram germinação satisfatória (1.25%. A cor do fruto é um parâmetro para indicação de maturidade fisiológica de sementes de Jatropha curcas Linn.

  11. Une méthode de calcul par éléments finis de la résistence de vague des corps flottants ou immergés en théorie linéaire A Finite Elements Method for Computing the Resistance of Floating Or Submerged Bodies to Wave Action Using a Linear Theory

    Cariou A.

    2006-11-01

    Full Text Available Pour calculer le potentiel de l'écoulement autour d'un corps en mouvement rectiligne uniforme, soit en fluide illimité (engin sous-marin, soit sur une mer infinie (corps flottant ou voisin de la surface libre, on se place dans le cadre du problème de Neumann extérieur ou du problème de Neumann Kelvin. Pour résoudre ces problèmes on se propose de délimiter autour de la carène un domaine fluide fini (,ri dont les frontières sont : la carène (SC, une surface (SE entourant la carène et éventuellement la portion de surface libre (SI. limitée par les lignes de flottaison de SC et SE. La solution à l'intérieur de (,ri est déterminée à l'aide d'une méthode d'éléments finis et elle est raccordée à la solution en domaine infini elle-même calculée grâce aux fonctions de Green du problème (ou solutions élémentaires. For computing the flow potential around a body in uniform rectilinear movement, either in an unlimited fluid (subsea croft or on an infinite sea (body floating near the free surface, consideration must be given ta the outside Neumann problem or ta the Neumann Kelvin problem. Ta solve these problems, this article proposes ta delimit a finite fluid realm (T: around the body. The limits of this realm are: I the body (SC, 2 a surface (SE surrounding the body, and eventually 3 the portion of free surface (SU bounded by the waterlines of SC and SE. The solution within iri is determined by a finite elements method, and it is related ta the solution in on infinite realm which in turn is computed by the Green functions of the problem (or elementary solutions.

  12. 專論/部落格使用者的資訊行為特徵研究/高世樺;林頌堅 | A Study of Features of Blog Users' Information Behaviors / Shih-Hua Kao; Sung-Chien Lin

    高世樺、林頌堅

    2008-04-01

    Full Text Available

    部落格已經成為諸多新科技中最具有影響力的媒體之一,並對於使用者的資訊尋求行為造成影響。本研究整理部落格的相關概念及功能,並以二十位部落格使 用者的訪談結果對部落格上的資訊尋求行為特徵進行描述。研究結果顯示,使用者在部落格的開始動機、連結方式、辨別標準、監看與提取方式等等都展現了十分豐 富的行為特徵,研究並發現;(1情感聯繫是受訪者經常提及的使用目標,並且這種動機也影響了各種行為特徵;(2使用者會依照自我的需求以及所處的情境 發展出合適的使用方式,這些新使用方式可能不同於發明者與推廣者所設想的最便於使用的功能;(3部落格上的個人經驗是使用者進行資訊尋求的主要原因之 一;(4豐富而精緻的圖像經常能夠吸引使用者進入部落格。

    Blog has already become one of the most influential media among new technologies, and has impacted on users’ information seeking behaviors. This research  utilized an interview survey to explore related concepts and unique functions of blog media. Interviews with 20 blog users were completed and analyzed to depict characteristics of information seeking behaviors founded in the use of blogs. The result shows that the users had performed a variety of behavioral features in motivations of using blogs, ways of linking from one blog to another, criteria of identification among blogs, methods of blog monitoring and extracting and so forth. Some major observations were also found during the interviews conducted: (1 emotion connection is frequently mentioned by users as one of their main purposes of using blogs, which can be found in each characteristic of information seeking behaviors; (2 when users use new functions of blog, based on their respective needs and situations they can develop their own strategies and methods, which can be very different from those provided or assumed by inventors and promoters; (3 personal experience shared by bloggers is one of the primary reasons why users employ blogs to find information needed; (4 abundant and delicate images embedded in blogs can always attract users’ attention.

    頁次:62-77

  13. Wpływ niektórych detergentów na przyrost biomasy Solanum lycopersicum i Scenedesmus quadricauda oraz na akumulację składników mineralnych u tych roślin [The effect of some detergents on the increase in biomass and the accumulation of mineral components in Solanum lycopersicum and Scenedesmus quadricauda

    St. Gumiński

    2015-01-01

    Full Text Available The investigation on water cultures of tomato seedlings and Scenedesmus quadricauda colonies have shown that low doses of the detergents stimulate the growth of these plants. An intensified accumulation of N, P, Ca, Mg, Fe and a reduced accumulation of K-ions have been observed.

  14. Custom Type-Curve Generation for Pressure Transient Analysis of Elongated Linear Flow Systems Génération de courbes caractéristiques de réponse en pression pour des systèmes linéaires longs

    Wagner P. B.

    2006-11-01

    Full Text Available When the drainage area of a flowing well is long and narrow, the pressure transient behavior of the well often cannot be analyzed by conventional means. Well tests which appear to exhibit linear flow behavior for extended periods, beyond the length of time which could be attributed to flow to a fracture, have been observed for both geothermal wells and for oil and gas wells. In geothermal formations and in some of the deep low-permeability gas fields the elongated reservoir shape results from long parallel faults which appear to bound the formations. Typically such wells are also penetrating natural fractures. In other reservoirs the elongated drainage shape is due to the river delta or alluvial environment in which the reservoir sands were originally deposited. Using a recently developed scheme for custom type curve generation for a wide variety of flow geometries, the particular behavior of the well producing from an elongated linear flow system is presented in detail. Cases examined include fractured wells of variable fracture length in varions positions within the flow channel and also of variable length. The effects of partial penetration are also demonstrated. This paper illustrates the use of custom type curves in computer-aided type-curve matching. With the help of relatively inexpensive computer graphics, custom type curves are displayed which exactly represent whatever is known about a particular drainage geometry, including such variables as formation thickness and areal extent, fracture length, partial penetration, and well location. Familles of curves can be generated and displayed along with the data to help determine unknown features of the reservoir geometry. An important contribution included in this work was the development of a set of orthogonal dimensionless parameters which facilitate the generation of familles of type curves which vary one reservoir shape parameter with implied effects on other parameters. The dimensionless solutions for any reservoir geometry are then readily developed for use in computer-aided type curve matching. Lorsque la zone de drainage d'un puits de production est longue et étroite, les méthodes classiques d'analyse du comportement des changements de pression ne peuvent être utilisées. De tels comportements, se prolongeant après la période pouvant être attribuée à une fracture, ont été observés pour des puits produisant de l'huile, du gaz et même pour certains puits géothermiques. La géométrie allongée, que l'on rencontre parfois dans certaines formations géothermiques et poches de gaz à grande profondeur et de faible perméabilité, peut être expliquée par des réseaux de fractures parallèles qui limitent la formation. Naturellement, les puits forés dans de telles formations peuvent traverser des fractures naturelles. Pour d'autres réservoirs, la forme allongée peut être causée par la géométrie de l'environnement dépositionnel deltaïque. Utilisant une méthode récemment développée permettant de produire des courbes caractéristiques de changement de pression pour une grande variété de géométries, le comportement particulier des puits drainant des formations allongées est présenté en détail. Les cas suivants ont été analysés : fissuration avec modification de la longueur de la fracture et diverses positions du puits dans la formation avec pénétration partielle de différentes longueurs. Les courbes sont construites directement sur le terminal. Elles prennent en compte exactement ce qui est connu de la géométrie du réservoir, de l'épaisseur, la forme, la longueur de la fissure, de la longueur de la zone perforée et de la position du puits. Des familles de courbes peuvent être générées et affichées, puis comparées aux données pour déterminer les paramètres inconnus de la géométrie du réservoir. Une contribution importante, présentée dans cet article, est le développement d'un système de paramètres orthogonaux sans dimensions qui facilite la génération des courbes caractéristiques. Les courbes caractéristiques de pression, correspondant à des géométries spécifiques à l'utilisateur, peuvent être superposées aux données de pressions en vue de déterminer les paramètres inconnus du réservoir (type curve matching.

  15. Comment on “High-temperature soft magnetic properties of antiperovskite nitrides ZnNFe{sub 3} and AlNFe{sub 3}” by Yankun Fu, Shuai Lin, and Bosen Wang, J. Magn. Magn. Mater. 378 (2015) 54–58

    Scholz, T. [Chair of Solid-State and Quantum Chemistry, Institute of Inorganic Chemistry, Landoltweg 1, RWTH Aachen University, D-52056 Aachen (Germany); Leineweber, A. [Institute of Materials Science, TU Bergakademie Freiberg, Gustav-Zeuner-Str. 5, D-09599 Freiberg (Germany); Dronskowski, R., E-mail: drons@HAL9000.ac.rwth-aachen.de [Chair of Solid-State and Quantum Chemistry, Institute of Inorganic Chemistry, Landoltweg 1, RWTH Aachen University, D-52056 Aachen (Germany)

    2016-10-15

    The authors of the aforementioned manuscript have recently claimed the synthesis of the ternary nitrides ZnNFe{sub 3} (=ZnFe{sub 3}N) and AlNFe{sub 3} (=AlFe{sub 3}N), ordered substituted variants of the binary phase γ‘-Fe{sub 4}N [1]. While soft ferromagnets of such kind are presently attracting lots of attention, their history dates back for more than half a century. In particular, Al-substituted γ‘-Fe{sub 4}N has already been mentioned in 1961 [2], and the existence of AlFe{sub 3}N has also been claimed in 2009 [3] from a two-step ammonolysis reaction combining a high-temperature sintering step and a low-temperature nitriding reaction [4]. Nonetheless, one of us had to withdraw the latter claim after finding out, by means of scanning-electron microscopy and elemental mapping, that all samples of “AlFe{sub 3}N” consisted of an intimate solid mixture of γ‘-Fe{sub 4}N and amorphous Al{sub 2}O{sub 3}[5]. From what follows, we have strong reasons to believe that the authors of Ref. [1] overlooked our findings [5] and also did not synthesize ZnFe{sub 3}N and AlFe{sub 3}N. - Highlights: • The synthesis of ZnFe{sub 3}N and AlFe{sub 3}N is questioned. • The diffraction data of ZnFe{sub 3}N and AlFe{sub 3}N resemble those of Fe{sub 4}N. • The magnetic data of ZnFe{sub 3}N and AlFe{sub 3}N are compatible with those of Fe{sub 4}N. • There is no physical evidence for the existence of ZnFe{sub 3}N and AlFe{sub 3}N.

  16. 實徵研究/國小教師以CREATER模式推動資訊素養創新課程之歷程/謝佩紋;林菁|The Process of Elementary School Teachers Implementing an Innovation Curriculum of Information Literacy with CREATER Model/Pei-Wen Hsieh; Lin Ching Chen

    謝佩紋、林菁 Pei-Wen Hsieh; Lin Ching Chen

    2009-04-01

    Full Text Available 本研究旨在探究國小教師推動資訊素養創新課程的歷程,並以CREATER革新模式的七個階段為架構,深入瞭解教師作為創新推動者在每個階段的經歷及結果,以提供有意推動資訊素養理念或其它創新的教育工作者參考。本研究採個案研究,以南部一所國小為研究個案,研究時間歷時一年半,透過觀察、訪談、文件分析等方法進行資料的蒐集。研究結果發現,國小教師推動資訊素養課程的歷程大致與CREATER模式的七個階段相符,但「關心」、「連結」與「檢視」階段並無明顯次序,教師以組織內成員的角色推動創新,能有效地將創新理念化為行動,但行動能否持續及發揮效果,還有賴團隊組成的完整性、教師的持續更新力及組織內掌握實權者的支持與參與。The purpose of this study was to explore the change process of implementing an information literacy curriculum by elementary school teachers. Based on the CREATER model, this study investigated the teachers’ experiences as change agents in each stage of the process. The research results could provide guidelines for educators who are devoted to promote the information literacy or other innovations. The method of case study was used to design this study. The subjects of this study were the teachers who voluntarily implemented the information literacy curriculum in an elementary school in the southern part of Taiwan. The methods for collecting research data were observations, interviews, and document analyses. The research results showed that the change process of implementing the information literacy curriculum corresponded to the seven stages of the CREATER model. However, the stages of “care,” “relate,” and “examine,” did not obviously happen in sequence. As members of the organization, the teachers could transform effectively the innovative concept into an action, but whether the innovation could be persistent depended on team relationships, teachers’ self-renewal capacity, and approvals and participation of the leaders who really managed the organization.頁次:70-89

  17. Aplicación del Método de Monte Carlo a la Planificación en Radioterapia y a la Reconstrucción de Espectros de Fotones de Aceleradores Lineales de Partículas (LinAc)

    Juste Vidal, Belen Jeanine

    2011-01-01

    La radioterapia es uno de los tratamientos más generalizados aplicados a los pacientes que padecen determinados tipos de cáncer. Sin embargo, la efectividad de este tipo de tratamientos en la destrucción de las células cancerígenas lleva asociada la posibilidad de sufrir los efectos secundarios de la radiación sobre los tejidos sanos circundantes. El riesgo de lesión de las células sanas depende fundamentalmente de la orientación del haz emitido por la unidad de radioterapia y de la intensida...

  18. Non-enzymatic hydrogen peroxide sensor based on Co 3 O 4 ...

    Author Affiliations. Guang Sheng Cao1 Lei Wang1 Pengfei Yuan1 Chao Gao1 Xiaojuan Liu1 Tong Li1 Tianmin Li1. Key Laboratory of Enhanced Oil and Gas Recovery of Ministry of Education, Northeast Petroleum University, Daqing 163318, China ...

  19. Bulletin of Materials Science | Indian Academy of Sciences

    Ping Chen1 2 Qing-Sheng Wu1 Ya-Ping Ding3 Pin-Shi Yuan1. Department of Chemistry, Tongji University, 1239 Siping Road, Shanghai 200092, P.R. China; Department of Chemistry, Chizhou College, Chizhou, Anhui 247000, P.R. China; Department of Chemistry, Shanghai University, Shanghai 200436, P.R. China ...

  20. 75 FR 20335 - Certain Oil Country Tubular Goods from the People's Republic of China: Final Determination of...

    2010-04-19

    ... limited service OCTG products) or unfinished (including green tubes and limited service OCTG products... also states that independent sources used to corroborate may include, for example, published price....... Pangang Group Chengdu Iron & Steel 29.94 Qingdao Bonded Logistics Park Products Shengli Oilfield Highland...

  1. A potential explanation for the effect of carbon source on the ...

    USER

    2010-08-16

    Aug 16, 2010 ... structure, mixed liquor suspended solids (MLSS), sludge volume index (SVI) .... Fine air bubbles for aeration were supplied through an air sparger at the ..... Ren TT, Liu L, Sheng GP, Liu XW, Yu HQ, Zhang MC, Zhu JR (2008).

  2. Journal of Genetics | Indian Academy of Sciences

    Home; Journals; Journal of Genetics. LIANG WANG. Articles written in Journal of Genetics. Volume 92 Issue 3 December 2013 pp 395-402 Research Article. Association of HS6ST3 gene polymorphisms with obesity and triglycerides: gene × gender interaction · Ke-Sheng Wang Liang Wang Xuefeng Liu Min Zeng.

  3. Association of HS6ST3 gene polymorphisms with obesity and ...

    Supplementary data: Association of HS6ST3 gene polymorphisms with obesity and triglycerides: gene × gender interaction. Ke-Sheng Wang, Liang Wang, Xuefeng Liu and Min Zeng. J. Genet. 92, 395–402. Table 1. Associations of 117 SNPs with obesity in the Health ABC and Marshfield samples. Minor. OR Health.

  4. Browse Title Index

    Items 501 - 550 of 1309 ... HH Tamboura, B Bayala, M Lompo, IP Guissou, L Sawadogo ... X Wang, Y-G Chen, L Ma, Z-H Li, J-Y Li, X-G Liu, J-L Zou, J-H Wu. Vol 11, No 2 ... Zhi-Jiang Wang, Wei Xu, Jian-Wen Liang, Cai-Sheng Wang, Yani Kang.

  5. Hap1 and GABA: thinking about food intake.

    Woods, Stephen C; Seeley, Randy J

    2006-06-01

    GABA stimulation of hypothalamic GABAA receptors increases food intake and body weight. Huntingtin-associated protein-1 (Hap1), is highly expressed in the hypothalamus and increases activity at GABAA receptors; mice lacking Hap1 are hypophagic. A recent paper (Sheng et al.,2006) further explores the role of Hap1 in the control of food intake.

  6. 76 FR 40804 - Technical Amendment to the Authorization Validated End-User Regulations of the Export...

    2011-07-12

    ... Di Sheng 3B001.c, 3B001.d, Street, BDA Beijing, 3B001.e, 3B001.f, China 100176. 3C001, 3C002, 3D002..., BDA Beijing, China 100176. Applied Materials (Xi'an) Ltd. No. 28 Xin Xi Ave., Xi'an High Tech Park...

  7. SHORT COMMUNICATION DETERMINATION OF CYPERMETHRIN ...

    Preferred Customer

    Spectra-physics SP8810 HPLC, equipped with UV detector; N-1NW revolving evaporator (Tokyo Physics and Chemistry Company, Japan); high-speed homogenizer (German. IKA Company); HY-4 timing multi-oscillator (JiangSu JinSheng Apparatus Factory); T500 electronic balance (ChangShu Testing Apparatus Factory); ...

  8. Knots and Links

    in a fashion similar to sound waves, whose medium is air. Ether was believed ..... [3] Colin C Adams, The Knot Book, W H Freeman and Company, New. York. ... [5] Kelly S Chichak, Stuart j CantriU, Antony R Pease, Sheng-Hsien. Chiu, Gareth ...

  9. “Falsification of Shakespeare”: Georgy Shengeli’s Unpublished Article on Boris Pasternak’s Translations

    Vladislav A. Rezvy

    2017-09-01

    Full Text Available In his article “Pasternak’s Shakespeare” (1945, Georgy Shengeli, poet, literary translator and expert in prosody, examines the fragments from Shakespeare’s tragedies Romeo and Juliet and Hamlet translated by Boris Pasternak, criticizing the latter in the light of his own views on translation, according to which accuracy and artistry are the main literary translation requirements. At the same time, Shengeli ignores the circumstances in which Pasternak made his translations as well as his intentions: to adapt Shakespeare to the Russian stage; the adaptation should be therefore judged as an original work of Russian literature.While recognizing natural and free syntax as an unquestionable merit of Pasternak’s translations, Shengeli seeks to prove by means of statistical calculations and line-by-line comparison of the translation with the original that Pasternak’s work is a falsification of Shakespeare. This essay shows how Shengeli, albeit aptly noting semantic and stylistic flaws in Pasternak’s translations, himself makes inaccuracies in the interpretation of the original and, in the spirit of the time, translates literary polemics into ideology, calling for “political conclusions.”

  10. Linkage disequilibrium and association mapping of drought ...

    sunny t

    2016-11-16

    Nov 16, 2016 ... related to drought tolerance (YongSheng et al., 2009). Among the variety of ... (Li et al., 2013), yield (LiFang et al., 2010) and fibre traits. (Islam et al., 2014). ..... such molecular markers as SSRs (Bertini et al., 2006;. Zhang et al.

  11. Download this PDF file

    ESLAM ABDELRAHEEM

    2013-04-24

    Apr 24, 2013 ... highly polluted wastewater are produced (Sheng and Chi,. 2003; Hoda et al., 2006; ... with the uptake of undesired ions from aqueous solutions using biological ..... favor the adsorption of positively charged dye cations due to electrostatic ... heavy metal biosorption characteristics of some algae. Process.

  12. Genomewide identification, classification and analysis of NAC type ...

    Supplementary data: Genomewide identification, classification and analysis of NAC type gene family in maize. Xiaojian Peng, Yang Zhao, Xiaoming Li, Min Wu, Wenbo Chai, Lei Sheng, Yu Wang, Qing Dong,. Haiyang Jiang and Beijiu Cheng. J. Genet. 94, 377–390. Table 1. Detailed information of NAC proteins in maize.

  13. Using datamining approaches to selectacupoints in acupuncture ...

    Using datamining approaches to selectacupoints in acupuncture and Moxibustion for knee osteoarthritis. Changyan Liu, Youxin Su, Jian He, Yanan Li, Shaoqing Chen, Yingjie Zhang, Ziyi Zhang, Meili Lu, Zhen He, Wenting Wang, Yiru Wang, Lu Sheng, Zhengxuan Zhan, Xu Wang, Naixi Zheng ...

  14. Rana nigromaculata

    ONLINE RESOURCES. Development and characterization of 13 polymorphic microsatellite DNA markers for the pond green frog (Rana nigromaculata). JIE GONG1,2, HONG LAN1,2, SHENG-GUO FANG1,2 and QIU-HONG WAN1,2∗. 1College of Life Sciences, Zhejiang University, Hangzhou 310058, People's Republic of ...

  15. Neutrino and dark matter physics with sub-keV germanium detectors

    2014-11-04

    Nov 4, 2014 ... Germanium detectors with sub-keV sensitivities open a window to study neutrino physics to search for light weakly interacting massive particle (WIMP) dark matter. We summarize the recent results on spin-independent couplings of light WIMPs from the TEXONO experiment at the Kuo-Sheng Reactor ...

  16. Clinical Manifestations of Multiple Sclerosis in Taiwanese Children

    J Gordon Millichap

    2006-11-01

    Full Text Available Twenty-one patients with multiple sclerosis (MS and onset before 18 years were treated over the past 22 years and their records retrospectively analyzed at the National Taiwan University Hospital, Taipei, and Min-Sheng General Hospital, Taoyuan, Taiwan.

  17. African Journal for the Psychological Study of Social Issues - Vol 5 ...

    The Influence of Gender and Self-Esteem on Attitude of Nigerians towards Foreign and Made in Nigeria Products · EMAIL FULL TEXT EMAIL FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. AA Kenku, SK Balogun, NA Shenge, 58-65 ...

  18. non absorbable sutures in the urinary bladder resulting

    The vesical calculus. Urol Clin North AM. 2000, 27:333-346. 3. Evans JW, Chapple CR, Ralph DJ, Millory EJ: Bladder calculus formation as a complication of the Stamey procedure. Br J Urol 1990,. 65:580-582. 4. Sheng-Tsun Su, He-Fu Haung, Shu-Fen. Chang. Encrusted Bladder stone on Non- absorbable sutures after a ...

  19. Bulletin of Materials Science | Indian Academy of Sciences

    2008-08-13

    Aug 13, 2008 ... Peng-Fei Yin1 2 Li-Li Sun1 3 You-Lu Gao2 Sheng-Yue Wang2. College of Science, Chongqing Jiaotong University, Chongqing 400074, P.R. China; Department of Physics, Southeast University, Nanjing 210096, P.R. China; Department of Physics, Third Military Medical University, Chongqing 400038, P.R. ...

  20. Bulletin of Materials Science | Indian Academy of Sciences

    Home; Journals; Bulletin of Materials Science; Volume 35; Issue 4. CuO/TiO2 nanocrystals grown on graphene as visible-light responsive photocatalytic hybrid materials. Yuan Fang Rijing Wang Guohua Jiang He Jin Yin Wang Xinke Sun Sheng Wang Tao Wang. Volume 35 Issue 4 August 2012 pp 495-499 ...

  1. 77 FR 60141 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    2012-10-02

    ... International, LLC of Redondo Beach, CA; Fellowes, Inc. of Itsaca, IL; Jie Sheng Technology of China; JWIN Electronics Corp., dba iLuv of Port Washington, NY; Project Horizon, Inc. dba InMotion Entertainment of Jacksonville, FL; ROCON Digital Technology Corp. of China; Shenzhen Huafeng Technology Co., Ltd. of China...

  2. A Business Sits on Relationship:A Reflective Analysis of Previous Working Experience

    Wang Lin

    2015-01-01

    This article is a case of study of the marketing strategy of Hua Sheng Da Zipper Manufacturing Company. This company is an example of small private enterprise trying to survive through the fierce competition all over China. By analyzing its market, this paper tries to demonstrate the mechanism of relationship in Chinese business context.

  3. Journal of Language, Technology & Entrepreneurship in Africa Vol ...

    User

    speaker's poor learning and mastery of other languages. ... Githiora (2002), on the other hand, calls it a Kiswahili-based patois which ... primary school students too, use Sheng' as their principle language outside of ... the youth living in the upper-middle, and middle income estates of Nairobi in ..... their science and their god.

  4. Human cytomegalovirus UL145 gene is highly conserved among ...

    PRAKASH KUMAR

    capable of causing infections that persist lifelong, and normally ... 1 Virus Laboratory, Affiliated ShengJing Hospital, China Medical University, Shenyang 110004, P. R. China. 2Department of .... Elmer, USA), and negative controls were included in each round of .... variability of the UL145 gene in field isolates. To answer this.

  5. A unifying framework for the problem of adjudicating conflicting claims

    Hougaard, Jens Leth; Østerdal, Lars Peter Raahave; Moreno-Terero, Juan D.

    2012-01-01

    operators in order to uncover the structure of such a space. In this paper, we generalize their analysis upon presenting and studying a general family of operators inspired by three apparently unrelated approaches to the problem of adjudicating conflicting claims. We study the structural properties......In a recent paper, Thomson and Yeh [Thomson, W., Yeh, C.-H., 2008. Operators for the adjudication of conflicting claims. Journal of Economic Theory 143, 177–198] introduced the concept of operators on the space of rules for the problem of adjudicating conflicting claims. They focused on three...... of this family and show, in particular, that most of Thomson and Yeh’s results are specific cases of our study....

  6. High Entropy Alloys: A Current Evaluation of Founding Ideas and Core Effects and Exploring Nonlinear Alloys (Postprint)

    2017-08-29

    299 (2004). 9. S. Ranganathan , Curr. Sci. 85, 1404 (2003). 10. F. Otto, Y. Yang, H. Bei, and E.P. George, Acta Mater. 61, 2628 (2013). 11. O.N...W. Yeh, and S. Ranganathan , High-Entropy Alloys (Oxford: Butterworth-Heinemann, 2014). 33. Y. Zou, S. Maiti, W. Steurer, and R. Spolenak, Acta Mater...Intermetallics 41, 96 (2013). 36. X. Yang and Y. Zhang, Mater. Chem. Phys. 132, 233 (2012). 37. S. Ranganathan , Personal communication (Bangalore: In

  7. Microstructure of Amorphous and Semi-Crystalline Polymers.

    1981-06-07

    in IFigure 1. Again. nf evidence ofan ii( hilar featir’s is seen and the comnbinaion of the bright-field and dark-field micrographs provides strfng...S. Y’. Yeh. (’re v1c". Aacrm ,l.m I 1rcm. I, 17311972). 5. S. Krinim and A. V. Tabo sky. Textile Res. J. 21, 805 (1951). 6. A. Bij rnhatig

  8. Controllable Tamm states in magnetophotonic crystal

    Merzlikin, A.M. [Institute for Theoretical and Applied Electromagnetics, Russian Academy of Science, 13/19 Izhorskaya ul., 125412 Moscow (Russian Federation); Vinogradov, A.P. [Institute for Theoretical and Applied Electromagnetics, Russian Academy of Science, 13/19 Izhorskaya ul., 125412 Moscow (Russian Federation)]. E-mail: a-vinogr@yandex.ru; Dorofeenko, A.V. [Institute for Theoretical and Applied Electromagnetics, Russian Academy of Science, 13/19 Izhorskaya ul., 125412 Moscow (Russian Federation); Inoue, M. [Department of Electrical and Electronic Engineering, Toyohashi University of Technology, 1-1 Hibari-Ga-Oka, Tempaku, Toyohashi 441-8580 (Japan); Levy, M. [Department of Physics, Michigan Technological University, 1400 Townsend Drive Houghton, MI 49931-1295 (United States); Granovsky, A.B. [Faculty of Physics, M.V. Lomonosov Moscow State University, Vorob' evy Gory, 119992 Moscow (Russian Federation)

    2007-05-15

    We study the Tamm states existing at the interface of a 1D magnetophotonic crystal made of magneto-optic material and a material with natural anisotropy. It is shown that in such a photonic crystal (PC) Yeh's band gap may exist, which causes a special type of the Tamm state. As this state is due to magneto-optic properties, it is controllable by an external magnetic field.

  9. Controllable Tamm states in magnetophotonic crystal

    Merzlikin, A.M.; Vinogradov, A.P.; Dorofeenko, A.V.; Inoue, M.; Levy, M.; Granovsky, A.B.

    2007-01-01

    We study the Tamm states existing at the interface of a 1D magnetophotonic crystal made of magneto-optic material and a material with natural anisotropy. It is shown that in such a photonic crystal (PC) Yeh's band gap may exist, which causes a special type of the Tamm state. As this state is due to magneto-optic properties, it is controllable by an external magnetic field

  10. A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome

    Huang, Jehn-Yu; Yeh, Po-Ting; Hou, Yu-Chih

    2016-01-01

    Jehn-Yu Huang, Po-Ting Yeh, Yu-Chih Hou Department of Ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan Purpose: To evaluate the efficacy of oral antioxidant supplementation in the treatment of patients with dry eye syndrome (DES). Methods: A prospective, randomized, double-blinded study compared the effects of an antioxidant supplement (containing anthocyanosides, astaxanthin, vitamins A, C, and E, and several herbal extract...

  11. The use of Optical Magnetic Twisting Cytometry and Flourescence Resonance Energy Transfer to quantify force-induced protein dissociation in the nucleus of a living cell

    sprotocols

    2015-01-01

    Authors: Yeh-Chuin Poh & Ning Wang ### Abstract Mechanical forces are known to play a significant role in biological processes. These forces can be transmitted to the cell through the cytoskeletal filament network, inducing different biochemical responses within the cytoplasm. Although there have been ample reports showing that cytoplasmic enzymes can be directly activated by a local stress on the cell surface via integrins, there has been no evidence that mechanical forces can direct...

  12. Supporting Battlefield Situation Assessment Through Attention Guidance and Diagnostic Aiding: A Cost-Benefit and Depth of Processing Analysis

    2001-12-01

    conceptual framework proposed by Craik and Lockhart (1972) offers a useful approach for examining depth of processing in an information integration task... processing ( Craik & Lockhart , 1972) for a particular unit (i.e., whether cueing decreased target sensitivity) (Yeh & Wickens, 2001). It was also predicted...F.I.M. & Lockhart , R.S. (1972). Levels of processing : A framework for memory research. Journal of Verbal Learning and Verbal Behavior, 11, 671-684

  13. Supporting Situation Assessment through Attention Guidance: A Cost-Benefit and Depth of Processing Analysis

    2001-01-01

    Factors, 30(1), 15-24. Craik , F.I.M. & Lockhart , R.S. (1972). Levels of processing : A framework for memory research. Journal of Verbal Learning and... processing ( Craik & Lockhart , 1972) for a particular unit (i.e., whether cueing would increase or decrease the memory for separate attributes of the cued...without processing these cues at a deeper level . Yeh and Wickens (2001, in press) found a similar response bias (beta) in observers who believed the

  14. The Effect of the Ionosphere on Radiowave Signals and Systems Performance Based on Ionospheric Effects Symposium Held on 1-3 May 1990

    1990-05-03

    extensive computer modeling studies were carried out, as summarized in reports and reviews by Croft, 1972; Testud , 1973; Hines, 1974; Yeh and Liu, 1974...1968) and Testud (1972), as a result of some complicated chemistry changes described by Hooke (1968). if the object of the investigation is to...B)l Testud (1972) showed that in addition to the electron density fluctuation, there are other effects complicating the AGW/TID coupling mechanism His

  15. Evaluation of the pressure difference across the core during PWR-LOCA reflood phase

    Iguchi, Tadashi; Murao, Yoshio

    1979-03-01

    The flooding rate of the core influences largely cooling of the core during the reflood phase of a PWR-LOCA. Since the void fraction of two-phase flow in the core is important determining the flooding rate, it is essential to examine this void fraction. The void fraction in the core during the reflood phase obtained by experiment was compared with those predicted by the correlations respectively of Akagawa, Nicklin, Zuber, Yeh, Griffice, Behringer and Jhonson. Only Yeh's correlation was found to be usable for the purpose. The pressure difference of the core during the reflood phase was calculated by reflood analyzing code REFLA-1D using Yeh's correlation. Following are the results: (1) During the steady-state period after quenching of the heaters, the prediction agrees within +-15% with the experiment. (2) During the transient period when the quench front is advancing, the prediction is not in agreement with the experiment, the difference being about +-40%. Influence of the advancing quench front upon the void fraction in the core must further be studied. (author)

  16. Security Enhanced User Authentication Protocol for Wireless Sensor Networks Using Elliptic Curves Cryptography

    Younsung Choi

    2014-06-01

    Full Text Available Wireless sensor networks (WSNs consist of sensors, gateways and users. Sensors are widely distributed to monitor various conditions, such as temperature, sound, speed and pressure but they have limited computational ability and energy. To reduce the resource use of sensors and enhance the security of WSNs, various user authentication protocols have been proposed. In 2011, Yeh et al. first proposed a user authentication protocol based on elliptic curve cryptography (ECC for WSNs. However, it turned out that Yeh et al.’s protocol does not provide mutual authentication, perfect forward secrecy, and key agreement between the user and sensor. Later in 2013, Shi et al. proposed a new user authentication protocol that improves both security and efficiency of Yeh et al.’s protocol. However, Shi et al.’s improvement introduces other security weaknesses. In this paper, we show that Shi et al.’s improved protocol is vulnerable to session key attack, stolen smart card attack, and sensor energy exhausting attack. In addition, we propose a new, security-enhanced user authentication protocol using ECC for WSNs.

  17. Security enhanced user authentication protocol for wireless sensor networks using elliptic curves cryptography.

    Choi, Younsung; Lee, Donghoon; Kim, Jiye; Jung, Jaewook; Nam, Junghyun; Won, Dongho

    2014-06-10

    Wireless sensor networks (WSNs) consist of sensors, gateways and users. Sensors are widely distributed to monitor various conditions, such as temperature, sound, speed and pressure but they have limited computational ability and energy. To reduce the resource use of sensors and enhance the security of WSNs, various user authentication protocols have been proposed. In 2011, Yeh et al. first proposed a user authentication protocol based on elliptic curve cryptography (ECC) for WSNs. However, it turned out that Yeh et al.'s protocol does not provide mutual authentication, perfect forward secrecy, and key agreement between the user and sensor. Later in 2013, Shi et al. proposed a new user authentication protocol that improves both security and efficiency of Yeh et al.'s protocol. However, Shi et al.'s improvement introduces other security weaknesses. In this paper, we show that Shi et al.'s improved protocol is vulnerable to session key attack, stolen smart card attack, and sensor energy exhausting attack. In addition, we propose a new, security-enhanced user authentication protocol using ECC for WSNs.

  18. An Analysis of Navy Nurse Corps Accession Sources

    2014-03-01

    1 I. INTRODUCTION A. BACKGROUND Since 1998, the United States has experienced a nationwide nursing shortage (Juraschek, Zhang, Ranganathan ...supply of RNs in the civilian workforce (Juraschek, Zhang, Ranganathan , & Lin, 2012). A study by Juraschek, Zhang, Ranganathan , & Lin (2012...Postgraduate School, Monterey, CA. Retrieved from www.dtic.mil/cgi- bin/GetTRDoc?AD=ADA344570 Juraschek, S. P., Zhang, X., Ranganathan , V. K., & Lin, V

  19. Biochemistry of Microbial Degradation of Hexachlorocyclohexane and Prospects for Bioremediation

    Lal, Rup; Pandey, Gunjan; Sharma, Pooja; Kumari, Kirti; Malhotra, Shweta; Pandey, Rinku; Raina, Vishakha; Kohler, Hans-Peter E.; Holliger, Christof; Jackson, Colin; Oakeshott, John G.

    2010-01-01

    Summary: Lindane, the γ-isomer of hexachlorocyclohexane (HCH), is a potent insecticide. Purified lindane or unpurified mixtures of this and α-, β-, and δ-isomers of HCH were widely used as commercial insecticides in the last half of the 20th century. Large dumps of unused HCH isomers now constitute a major hazard because of their long residence times in soil and high nontarget toxicities. The major pathway for the aerobic degradation of HCH isomers in soil is the Lin pathway, and variants of this pathway will degrade all four of the HCH isomers although only slowly. Sequence differences in the primary LinA and LinB enzymes in the pathway play a key role in determining their ability to degrade the different isomers. LinA is a dehydrochlorinase, but little is known of its biochemistry. LinB is a hydrolytic dechlorinase that has been heterologously expressed and crystallized, and there is some understanding of the sequence-structure-function relationships underlying its substrate specificity and kinetics, although there are also some significant anomalies. The kinetics of some LinB variants are reported to be slow even for their preferred isomers. It is important to develop a better understanding of the biochemistries of the LinA and LinB variants and to use that knowledge to build better variants, because field trials of some bioremediation strategies based on the Lin pathway have yielded promising results but would not yet achieve economic levels of remediation. PMID:20197499

  20. New Approaches for Prostate Cancer Combination Therapy

    2009-04-01

    Freemont AJ, et al. E - cadherin and h-catenin are down-regulated in prostatic bone metastases. BJU Int 2002;89:400–3. ...ola r Di clo fen ac 20 Di clo fen ac 10 Di clo fen ac 5 Su lin da c S ulf on e 2 00 Su lin da c S ulf on e 1 00 Su lin da c S ulf on e 5 0 Su...lin da c S ulf on e 2 5 Flu rb ipr ofe n 2 0 Flu rb ipr ofe n 1 0 Flu rb ipr ofe n 5 Flu rb ipr ofe n 2 As pir

  1. 314 A Study of Secondary School Students' Academic Performance ...

    User

    Students' Academic Performance in English Language and Mathematics ... passed at credit level by secondary schools students in public examinations. A credit level ..... ls O n lin e: www.a jo l.in fo. T ab le 1. : P ercen tage of p asses and failu.

  2. Photonic-Networks-on-Chip for High Performance Radiation Survivable Multi-Core Processor Systems

    2013-12-01

    Loss Spectra” Proceedings of SPIE 8255, (2012) and in a journal publication: M. T. Crowley, D. Murrell, N. Patel, M. Breivik , C.-Y. Lin, Y. Li, B.-O...Crowley, D. Murrell, N. Patel, M. Breivik , C.-Y. Lin, Y. Li, B.-O. Fimland and L. F. Lester, "Analytical Modeling of the Temperature Performance of

  3. Download this PDF file

    Dr Olaleye

    Histological assessment of the gastric mucosa and submucosa revealed infiltration by inflammatory cells in normal ... Gastric ulcer, also known as peptic ulcer, is a localized area of erosion in ..... and water retention by interfering with the prostaglandin induced ... Clark JD, Lin LL, Kriz RW, Ramesha CS, Sultzman LA,. Lin AY ...

  4. Single-tube linear DNA amplification for genome-wide studies using a few thousand cells

    Shankaranarayanan, P.; Mendoza-Parra, M.A.; Gool, van W.; Trindade, L.M.; Gronemeyer, H.

    2012-01-01

    Linear amplification of DNA (LinDA) by T7 polymerase is a versatile and robust method for generating sufficient amounts of DNA for genome-wide studies with minute amounts of cells. LinDA can be coupled to a great number of global profiling technologies. Indeed, chromatin immunoprecipitation coupled

  5. Aldehyde Dehydrogenase 1 and Raf Kinase Inhibitor Protein ...

    Xiang-Xiu Sun1, Qing-Shan Ma2, Tian-Feng Liu1, Ying Chen1, Yan Dong1 and. Lin-Lin Zhang1* ... cancer was developed and studied by histological examination. Immunohistochemical and .... (diaminobenzidine) Kit. Western blot analysis.

  6. 75 FR 4509 - Uniform Criteria for State Observational Surveys of Seat Belt Use

    2010-01-28

    ... statistical issues: Ms. Chou-Lin Chen, Chief, Mathematical Analysis Division, National Center for Statistics..., Washington, DC 20590. Telephone number: 202-366-1048; E- mail: Chou-Lin.Chen@dot.gov . For legal issues: Ms..., and reduce burden. E. Paperwork Reduction Act Under the Paperwork Reduction Act of 1995, a person is...

  7. Water SA - Vol 40, No 2 (2014)

    The development of GIS-PMWIN and its application for mine-water modelling in the Far West Rand, South Africa · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. H Lin, L Lin, 313-322. http://dx.doi.org/10.4314/wsa.v40i2.13 ...

  8. Blood-brain transfer and antinociception of linear and cyclic N-methyl-guanidine and thiourea-enkephalins

    Verbeken, Mathieu; Wynendaele, Evelien; Mauchauffee, Elodie

    2015-01-01

    Enkephalins are active in regulation of nociception in the body and are key in development of new synthetic peptide analogs that target centrally located opioid receptors. In this study, we investigated the in vivo blood–brain barrier (BBB) penetration behavior and antinociceptive activity of two...... cyclic enkephalin analogs with a thiourea (CycS) or a N-methyl-guanidine bridge (CycNMe), and their linear counterparts (LinS and LinNMe) in mice, as well as their in vitro metabolic stability. 125I-LinS had the highest blood–brain clearance (K1 = 3.46 μL/g min), followed by 125I-LinNMe, 125I...

  9. A rotordynamic analysis of circumferentially-grooved pump seals based on a three-control-volume theory

    Ha, Tae Woong; Lee, An Sung

    2000-01-01

    In this paper the leakage prediction and rotordynamic analysis of an annular seal with a smooth rotor and circumferentially grooved stator are performed based on a three-control-volume theory. The present analysis is validated by comparing with the experimental data of Iwatsubo and Sheng and theoretical results suggested by Marquette and Childs. For the leakage prediction the present analysis shows a good agreement with Marquette and Childs' result and a qualitation agreement with Iwatsubo and Shengs' experimental data. Direct and cross-coupled stiffness coefficients show closer agreement with the experimental values than those of Marquette and Childs. However, direct damping coefficient shows greater discrepancy from the experimental value than Marquette and Childs'

  10. Over My Dead Body! Media Constructions of Forced Prostitution in the People's Republic of China

    Elaine Jeffreys

    2006-09-01

    Full Text Available This paper examines some of the tensions surrounding the PRC’s official policy of banning prostitution by focusing on two highly publicized cases of deceptive recruiting for sexual services—the ‘Tang Shengli Incident’ and the ‘Liu Yanhua Incident’. Both cases involve young rural women who had migrated from their native homes to other more economically developed parts of China to look for work. Both were forced to sell sex and both resisted. However, whereas Tang Shengli jumped from a building rather than be forced into prostitution, Liu Yanhua escaped from conditions akin to sexual servitude by stabbing her ‘employer’. An examination of these cases highlights some of the problems associated with efforts by the Chinese women’s media to promote and protect women’s rights in a country marked by rapid, yet unequal, economic growth and an expanding, albeit banned, sex industry.

  11. Apatinib plus icotinib in treating advanced non-small cell lung cancer after icotinib treatment failure: a retrospective study

    Xu, Jianping; Liu, Xiaoyan; Yang, Sheng; Zhang, Xiangru; Shi, Yuankai

    2017-01-01

    Jianping Xu, Xiaoyan Liu, Sheng Yang, Xiangru Zhang, Yuankai Shi Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Beijing, People’s Republic of China Background: Treatment failure frequently occurs in patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) who resp...

  12. Efficacy and safety of icotinib in patients with brain metastases from lung adenocarcinoma

    Xu, Jianping; Liu, Xiaoyan; Yang, Sheng; Zhang, Xiangru; Shi, Yuankai

    2016-01-01

    Jianping Xu, Xiaoyan Liu, Sheng Yang, Xiangru Zhang, Yuankai Shi Department of Internal Medicine, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China Objective: The objective of this study was to evaluate the efficacy and safety of icotinib in patients with brain metastases (BMs) from lung adenocarcinoma.Patients and methods: Clinical data of 28 cases with BMs from lung adenocarcinoma were retrospectively analyzed. All the patients took 125&am...

  13. China Debates the Future Security Environment

    2000-01-01

    Bike, Zhot~uo da qushi (China megatrends )( Belling: Hualing chubanshe, 1996). For warnings on the need to conceal increasing national power, see Ma...became Japan’s prime minister in 1957. Troop 731, which had engaged in biological warfare experiments, was exempted from trial. In March 1950, all...gongye chubanshe, 1998. Lu Hui. He hua sheng wuqi de h’shi yu weilai CFhe history and future of nuclear, chemical, and biological weapons). Beijing

  14. Nonlinear Photonic Systems for V- and W-Band Antenna Remoting Applications

    2016-10-22

    AFRL-AFOSR-JP-TR-2016-0088 Nonlinear Photonic Systems for V- and W-Band Antenna Remoting Applications Sheng-Kwang Hwang NATIONAL CHENG KUNG...2016 2. REPORT TYPE Final 3. DATES COVERED (From - To) 26 May 2015 to 25 May 2016 4. TITLE AND SUBTITLE Nonlinear Photonic Systems for V- and W-Band...TERMS nonlinear, photonic , antenna, remote, microwave, amplification, bandwith, modulation 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT SAR

  15. The U.S. Imperative on the Senkaku/Diaoyu Territorial Dispute

    2013-03-01

    1893, Sheng Xuanhuai, a Qing Dynasty statesman, collected medical herbs on the Diaoyu Islands. China argues that this proves that China was first to...The ECAFE report concluded that substantial deposits of hydrocarbons potentially existed in the seabed between Taiwan and Japan. The report...maritime safety vessels and aircraft drove the Taiwanese boats back. This sparked anti-Japanese protests throughout Taiwan .15 Subsequently, the

  16. AFOSR Mission Critical STEAM Program

    2014-02-10

    Psychology 3.25 Junior Devin Frederick Computer Science 3.26 Junior Michael Johnson Computer Science 3.8 Junior Tre Addison Computer Science 3.6...universities on the island and has a strong tradition of training leaders in engineering and entrepreneurship . 28 The TMCF delegation met with Dr. Sheng...of relevant theory and data on research-based interventions in Vocational Psychology that can be used to develop programs and support services to

  17. Protocol for evaluating Epigenetic modulation of the renal β-adrenergic-WNK4 pathway in salt-sensitive hypertension

    sprotocols

    2015-01-01

    Authors: ShengYu Mu, Tatsuo Shimosawa & Toshiro Fujita ### Abstract In the current study, we found that β2 adrenergic receptor (β2AR) stimulation induced histone acetylation through HDAC8 inhibition, and then decreased transcription of the WNK4 gene by enhancing the binding of glucocorticoid receptor (GR) and negative-GR-responsive-element (nGRE) in WNK4 promoter region. Infusion of isoproterenol decreased WNK4 expression and activated the Na+-Cl- co-transporter in mice, which develop...

  18. Sustained release of vancomycin from novel biodegradable nanofiber-loaded vascular prosthetic grafts: in vitro and in vivo study

    Liu, Kuo-Sheng; Lee, Cheng-Hung; Wang, Yi-Chuan; Liu, Shih-Jung

    2015-01-01

    Kuo-Sheng Liu,1 Cheng-Hung Lee,2 Yi-Chuan Wang,3 Shih-Jung Liu3 1Department of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan; 2Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan; 3Department of Mechanical Engineering, Chang Gung University, Tao-Yuan, Taiwan Abstract: This study describes novel biodegradable, drug-eluting nanofiber-loaded vascular prosthetic grafts that provide local and sustained...

  19. Treatment and Remediation of Petroleum-Contaminated Soils Using Selective Ornamental Plants

    Liu, Rui; Jadeja, Rajendrasinh N.; Zhou, Qixing; Liu, Zhe

    2012-01-01

    Pot-culture experiments were carried out to assess the phytoremediation potential of 14 ornamental plants in weathered petroleum-contaminated soil, which was collected in the Shengli Oil Field, one of the biggest oil fields in China, by examining their impact on the degradation potential of total petroleum hydrocarbons (TPHs) and its composition. Results showed Gaillardia aristata, Echinacea purpurea, Fawn (Festuca arundinacea Schreb), Fire Phoenix (a combined F. arundinacea), and Medicago sa...

  20. A Partnership Training Program: Studying Targeted Drug Delivery Using Nanoparticles in Breast Cancer Diagnosis and Therapy

    2013-10-01

    Cancer Res, 6, 3056 (2000). 33. Dijkgraaf I, Beer AJ, Wester HJ, Front Biosci, 14, 887 (2009). 34. Lim EH, Danthi N, Bednarski M, Li KC , Nanomedicine, 1...Biol 2007;34:229-32. 34. Wang HH, Wang YX, Leung KC , Au DW, Xuan S, Chak CP, Lee SK, Sheng H, Zhang G, Qin L, Griffith JF, Ahuja AT. Durable...arylamide) (MBA), 3-(trimethoxysilyl) propylmethacrylate (MPS), tetraethoxysilane ( TEOS ), 3-(4,5)- dimethylthiahiazo(-z-yl)-3,5

  1. Morphological Variation in the Imperfect of hewâ in Onqelos and Jonathan

    Jerome A. Lund

    2018-06-01

    Full Text Available Two morphological types of the imperfect of the verb hewâ appear in Onqelos and Jonathan, namely yihwê and yehê. While the two types distinguish gender in the plural, they do not do so in the singular. Statistically, the waw type is marginal in the second and third persons singular, but well attested in the first person singular. The use of the waw type in the singular appears to be conditioned by stylistic considerations, being employed to give the impression of solemnity. It is suggested that the waw type reflects the language of the proto-targum from which it was retained.

  2. Handbook of fiber optics theory and applications

    Yeh, Chai

    2013-01-01

    Dr. Yeh supplies a firm theoretical foundation in such topics as propagation of light through fibers, fiber fabrication, loss mechanisms, and dispersion properties. He then expands from this into such practical areas as fiber splicing, measuring loss in fibers, fiber-based communications networks, remote fiber sensors, and integrated optics. Whether involved in fiber optics research, design, or practical implementation of systems, this handbook will be extremely useful.Key Features* Here is a comprehensive, ""one-stop"" reference with state-of-the-art information on fiber optics Included is da

  3. Accelerated Exploration of Multi-principal Element Alloys for Structural Applications (Postprint)

    2015-04-27

    S. Ranganathan, High Entropy Alloys, Butterworth-Hei- nemann, London, UK, 2014. [6] B. Cantor , I.T.H. Chang, P. Knight, A.J.B. Vincent, Mater. Sci...Kristallogr.-Cryst. Mater. 230 (2015) 55–68. [14] B. Cantor , Entropy 16 (2014) 4749–4768. [15] O.N. Senkov, C. Woodward, D.B. Miracle, JOM. 66 (2014...2014) 1973–1983. [21] F. Otto, Y. Yang, H. Bei, E.P. George , Acta Mater. 61 (2013) 2628–2638. [22] K.Y. Tsai, M.H. Tsai, J.W. Yeh, Acta Mater. 61

  4. A Unifying Framework for the Problem of Adjudicating Conflicting Claims

    Hougaard, Jens Leth; Moreno-Ternero, Juan D.; Østerdal, Lars Peter Raahave

    the structure of such a space. In this paper, we generalize their analysis upon presenting and studying a general family of operators inspired by three apparently unrelated approaches to the problem of adjudicating conflicting claims. We study the structural properties of this family and show, in particular......In a recent paper, Thomson and Yeh [Operators for the adjudication of conflicting claims, Journal of Economic Theory 143 (2008) 177-198] introduced the concept of operators on the space of rules for the problem of adjudicating conflicting claims. They focussed on three operators in order to uncover...

  5. Combined Effects of Primary and Tertiary Blast on Rat Brain: Characterization of a Model of Blast-induced Mild Traumatic Brain Injury

    2013-03-01

    injury in U.S. military personnel. N Engl J Med 364, 2091–2100 (2011) 27. Lu J, Ng KC , Ling GS, Wu J, Poon JF, Kan EM, Tan MH, Wu YJ, Li P...Moochhala S, Yap E, Lee LK, Teo AL, Yeh IB, Ser- gio DM, Chua F, Kumar SD, Ling EA: Effect of blast exposure on the brain structure and cognition in the...12689448] 32. Henderson D, Bielefeld EC, Harris KC , Hu BH. The role of oxidative stress in noise-induced hearing loss. Ear Hear. 2006;27(1):1–19. [PMID

  6. The Mesosphere and Thermosphere,

    1981-01-01

    and Joule heating (Q = J.E) and has been studied by many authors (see e.g. [40] and references therein). Testud [41] found that the efficiency of...K/day, respectively. Testud and Vasseur [611 observed a T.I.D. following a magnetic storm and noted that the ion temperature at the 300 km level rose... Testud [62] and Yeh [30] have estimated that heating rates of the order of 10 - 0 watts/m 3 (10 - 9 ergs/cm 3 sec) occur at F-region heights due

  7. Pharmacological Characterization of 5-Substituted 1-[(2,3-dihydro-1-benzofuran-2-ylmethyl]piperazines: Novel Antagonists for the Histamine H3 and H4 Receptors with Anti-inflammatory Potential

    Michelle F. Corrêa

    2017-11-01

    Full Text Available The histamine receptors (HRs are traditional G protein-coupled receptors of extensive therapeutic interest. Recently, H3R and H4R subtypes have been targeted in drug discovery projects for inflammation, asthma, pain, cancer, Parkinson’s, and Alzheimer’s diseases, which includes searches for dual acting H3R/H4R ligands. In the present work, nine 1-[(2,3-dihydro-1-benzofuran-2-ylmethyl]piperazine (LINS01 series molecules were synthesized and evaluated as H3R and H4R ligands. Our data show that the N-allyl-substituted compound LINS01004 bears the highest affinity for H3R (pKi 6.40, while the chlorinated compound LINS01007 has moderate affinity for H4R (pKi 6.06. In addition, BRET assays to assess the functional activity of Gi1 coupling indicate that all compounds have no intrinsic activity and act as antagonists of these receptors. Drug-likeness assessment indicated these molecules are promising leads for further improvements. In vivo evaluation of compounds LINS01005 and LINS01007 in a mouse model of asthma showed a better anti-inflammatory activity of LINS01007 (3 g/kg than the previously tested compound LINS01005. This is the first report with functional data of these compounds in HRs, and our results also show the potential of their applications as anti-inflammatory.

  8. Production and characterization of nanocapsules encapsulated linalool by ionic gelation method using chitosan as wall material

    Zuobing XIAO

    Full Text Available Abstract Linalool has been extensively applied in various fields, such as flavoring agent, perfumes, cosmetics and medical science. However, linalool is unstable, volatile and readily oxidizable. A sensitive substance can be encapsulated in a capsule, so encapsulation technology can solve these problems. In this paper, linalool-loaded nanocapsules (Lin-nanocapsules were prepared via the ionic gelation method and Lin-nanocapsules were characterized. The results of Fourier transformation infrared spectroscopy (FTIR showed that linalool was successfully encapsulated in the wall materials. Scanning electron microscopy (SEM results demonstrated that the shapes of Lin-nanocapsules, with smooth surfaces, were nearly spherical. Lin-nanocapsule average particle size was 352 nm and its polydispersity index (PDI was proved to be 0.214 by the results of dynamic light scattering (DLC. Thermogravimetric results indicated that linalool loading capacity (LC was 15.17%, and encapsulation could decrease linalool release and increase linalool retaining time under the high temperature. Oscillatory shear and steady-state shear measurements of Lin-nanocapsule emulsions were systematically investigated. The results of steady-state shear showed that Lin-nanocapsule emulsion, which was Newtonian only for high shear rate, was non-Newtonian. It was proved by oscillatory shear that when oscillation frequency changed from low to high, Lin-nanocapsules emulsion changed from viscous into elastic.

  9. Smart Methods for Linezolid Determination in the Presence of Alkaline and Oxidative Degradation Products Utilizing Their Overlapped Spectral Bands

    Abd El-Monem Hegazy, M.; Shaaban Eissa, M.; Abd El-Sattar, O. I.; Abd El-Kawy, M. M.

    2014-09-01

    Linezolid (LIN) is considered the first available oxazolidinone antibacterial agent. It is susceptible to hydrolysis and oxidation. Five simple, accurate, sensitive and validated UV spectrophotometric methods were developed for LIN determination in the presence of its alkaline (ALK) and oxidative (OXD) degradation products in bulk powder and pharmaceutical formulation. Method A is a second derivative one (D2) in which LIN is determined at 240.9 nm. Method B is a pH-induced differential derivative one where LIN is determined using the fourth derivative (D4) of the difference spectra (ΔA) at 285.3 nm. Methods C, D, and E are manipulating ratio spectra, where C is the double divisor-ratio difference spectrophotometric one (DD-RD) in which LIN was determined by calculating the amplitude difference at 243.7 and 267.6 nm of the ratio spectra. Method D is the double divisor-first derivative of ratio spectra (DD-DD1) in which LIN was determined at 270.2 nm. Method E is a mean centering of ratio spectra one (MCR) in which LIN was determined at 318.0 nm. The developed methods have been validated according to ICH guidelines. The results were statistically compared to that of a reported HPLC method and there was no significant difference regarding both accuracy and precision.

  10. Essential Oil of Ocimum basilicum L. and (−-Linalool Blocks the Excitability of Rat Sciatic Nerve

    Antonio Medeiros Venancio

    2016-01-01

    Full Text Available The racemate linalool and its levogyrus enantiomer [(−-LIN] are present in many essential oils and possess several pharmacological activities, such as antinociceptive and anti-inflammatory. In this work, the effects of essential oil obtained from the cultivation of the Ocimum basilicum L. (EOOb derived from Germplasm Bank rich in (−-LIN content in the excitability of peripheral nervous system were studied. We used rat sciatic nerve to investigate the EOOb and (−-LIN effects on neuron excitability and the extracellular recording technique was used to register the compound action potential (CAP. EOOb and (−-LIN blocked the CAP in a concentration-dependent way and these effects were reversible after washout. EOOb blocked positive amplitude of 1st and 2nd CAP components with IC50 of 0.38±0.2 and 0.17±0.0 mg/mL, respectively. For (−-LIN, these values were 0.23±0.0 and 0.13±0.0 mg/mL. Both components reduced the conduction velocity of CAP and the 2nd component seems to be more affected than the 1st component. In conclusion EOOb and (−-LIN inhibited the excitability of peripheral nervous system in a similar way and potency, revealing that the effects of EOOb on excitability are due to the presence of (−-LIN in the essential oil.

  11. In reactor measurements, modeling and assessments to predict liquid injection shutdown system nozzle to Calandria tube time to contact

    Kirstein, K.; Kalenchuk, D.

    2011-01-01

    Over the past few years there has been an expanding effort to assess the potential for Calandria Tubes (CTs) coming into contact with Liquid Injection Shutdown System (LISS) Nozzles to ensure continued contact-free operation as required by CSA N285.4. LISS Nozzles (LINs), which run perpendicular to and between rows of fuel channels, sag at a slower rate than the fuel channels. As a result certain LINs may come in contact with CTs above them. The CT/LIN gaps can be predicted from calculated CT sag, LIN sag and a number of component and installation tolerances. This method however results in very conservative predictions when compared to measurements, confirmed with the in reactor measurements initiated in 2000, when gaps were successfully measured the first time using images obtained from a camera-assisted measurement tool inserted into the calandria. To reduce the conservatism of the CT/LIN gap predictions, statistical CT/LIN gap models are used instead. They are derived from a comparison between calculated gaps based on nominal dimensions and the visual image based measured gaps. These reactor specific (typically 95% confidence level) CT/LIN gap models account for all uncertainties and deviations from nominal values. Prediction error margins reduce as more in-reactor gap measurements become available. Each year more measurements are being made using this standardized visual CT/LIN proximity method. The subsequently prepared reactor-specific models have been used to provide time to contact for every channel above the LINs at these stations. In a number of cases it has been used to demonstrate that the reactor can be operated to its end of life before refurbishment with no predicted contact, or specific at-risk channels have been identified for which appropriate remedial actions could be implemented in a planned manner. (author)

  12. Theoretical studies of the global minima and polarizabilities of small lithium clusters

    Hu, Hanshi; Zhao, Ya-Fan; Hammond, Jeffrey R.; Bylaska, Eric J.; Apra, Edoardo; van Dam, Hubertus JJ; Li, Jun; Govind, Niranjan; Kowalski, Karol

    2016-01-16

    Lithium clusters Lin (n=1-20) have been investigated with density functional theory (DFT) and coupled—cluster (CC) methods. The global-minimum structures are located via an improved basin---hopping algorithm and the lowest energy Lin isomers are confirmed with DFT geometry optimizations, CCSD(T) energy calculations, and by comparing simulated and experimental polarizabilities. The tetrahedral Li4 structure is found to be the basic building block of lithium clusters Lin (n=6-20). Simulated polarizabilities, including thermal effects at room temperature, are in good agreement with measured isotropic polarizabilities.

  13. Three new species of Begonia (Begoniaceae from Limestone Hills in southwestern Sarawak, Borneo

    Che-Wei Lin

    2017-04-01

    Full Text Available Most species of Begonia in Borneo, like those of other areas, are narrowly distributed and site-specific. In this study we report three new species of Begonia, namely B. felis C. W. Lin & C.-I Peng, B. kuchingensis C. W. Lin & C.-I Peng (sect. Petermannia and B. serianensis C. W. Lin & C.-I Peng (sect. Reichenheimia from the Padawan-Serian limestone hills in southwestern Sarawak. In addition to the taxonomic account, color plates, line drawings, a distribution map, and comparisons with phenetically similar species are provided to aid in identification.

  14. Verification and Validation of the Coastal Modeling System. Report 1: Summary Report

    2011-12-01

    Center, Coastal and Hydraulics Laboratory, Vicksburg, MS. Li, H., L. Lin, C. Lu and A.T. Shak . 2011 (In press). Evaluation of Breakwaters and...cirp.usace.army.mil/pubs/html/09-Li-Brown_TR-09-19.html, accessed 7 June 2011. Li, H., L. Lin, C. Lu andA.T. Shak . 2011 In press. Evaluation of Breakwaters and...TR-11-10 87 Reference: Li, H., L. Lin, C. Lu and A.T. Shak . 2011. Evaluation of Breakwaters and Sedimentation at Dana Point Harbor, CA

  15. EDITORIAL: Big challenges and nanosolutions Big challenges and nanosolutions

    Demming, Anna

    2011-07-01

    population dynamics will evolve throughout future generations attracts considerable debate and a range of strong opinions. But in the meantime, as this issue's review highlights, there is a great deal of scope in exploiting nanotechnology to find potential technological solutions to the challenges increasing populations pose at present. And that's not to mention the intriguing insights into nanoscale physics that may be discovered along the way. References [1] Penza M, Rossi R, Alvisi M and Serra E 2010 Nanotechnology 21 105501 [2] Gu B, Zhu Y, Chang J, Peng C, Liu D, Min Y, Luo W, Howarth R W and Ge Y 2011 Environ. Res. Lett. 6 014011 [3] Galloway J N, Townsend A R, Erisman J W, Bekunda M, Cai Z, Freney J R, Martinelli L A, Seitzinger S P and Sutton M A 2008 Science 320 889-92 [4] Humplik T et al 2011 Nanotechnology 22 292001 [5] Guo Z, Meng F, Luo T, Li M and Liu J 2009 Nanotechnology 20 125501 [6] Chen Y, Chen Z, He Y, Lin H, Sheng P, Liu C, Luo S and Cai Q 2010 Nanotechnology 20 105102 [7] Ren L, Ma L, Jin L, Wang J-B, Qiu M and Yu Y 2009 Nanotechnology 20 405602 [8] Wang Y, Wang G, Wang H, Cai W, Liang C and Zhang L 2009 Nanotechnology 20 156604 [9] Hardin G 1968 Science 162 1243-8

  16. Formation and mobilization of neutral lipids in the yeast Saccharomyces cerevisiae.

    Wagner, A; Daum, G

    2005-11-01

    Since energy storage is a basic metabolic process, the synthesis of neutral lipids occurs in all kingdoms of life. The yeast Saccharomyces cerevisiae, widely accepted as a model eukaryotic cell, contains two classes of neutral lipids, namely STEs (steryl esters) and TAGs (triacylglycerols). TAGs are synthesized through two pathways governed by the acyl-CoA diacylglycerol acyltransferase Dga1p and the phospholipid diacylglycerol acyltransferase Lro1p. STEs are formed by two STE synthases Are1p and Are2p, two enzymes with overlapping function, which also catalyse TAG formation, although to a minor extent. Neutral lipids are stored in the so-called lipid particles and can be utilized for membrane formation under conditions of lipid depletion. For this purpose, storage lipids have to be mobilized by TAG lipases and STE hydrolases. A TAG lipase named Tgl3p was identified as a major yeast TAG hydrolytic enzyme in lipid particles. Recently, a new family of hydrolases was detected which is required for STE mobilization in S. cerevisiae. These enzymes, named Yeh1p, Yeh2p and Tgl1p, are paralogues of the mammalian acid lipase family. The role of these proteins in biosynthesis and mobilization of TAG and STE, and the regulation of these processes will be discussed in this minireview.

  17. Comparisons of Particle Tracking Techniques and Galerkin Finite Element Methods in Flow Simulations on Watershed Scales

    Shih, D.; Yeh, G.

    2009-12-01

    This paper applies two numerical approximations, the particle tracking technique and Galerkin finite element method, to solve the diffusive wave equation in both one-dimensional and two-dimensional flow simulations. The finite element method is one of most commonly approaches in numerical problems. It can obtain accurate solutions, but calculation times may be rather extensive. The particle tracking technique, using either single-velocity or average-velocity tracks to efficiently perform advective transport, could use larger time-step sizes than the finite element method to significantly save computational time. Comparisons of the alternative approximations are examined in this poster. We adapt the model WASH123D to examine the work. WASH123D is an integrated multimedia, multi-processes, physics-based computational model suitable for various spatial-temporal scales, was first developed by Yeh et al., at 1998. The model has evolved in design capability and flexibility, and has been used for model calibrations and validations over the course of many years. In order to deliver a locally hydrological model in Taiwan, the Taiwan Typhoon and Flood Research Institute (TTFRI) is working with Prof. Yeh to develop next version of WASH123D. So, the work of our preliminary cooperationx is also sketched in this poster.

  18. Mobilization of steryl esters from lipid particles of the yeast Saccharomyces cerevisiae.

    Wagner, Andrea; Grillitsch, Karlheinz; Leitner, Erich; Daum, Günther

    2009-02-01

    In the yeast as in other eukaryotes, formation and hydrolysis of steryl esters (SE) are processes linked to lipid storage. In Saccharomyces cerevisiae, the three SE hydrolases Tgl1p, Yeh1p and Yeh2p contribute to SE mobilization from their site of storage, the lipid particles/droplets. Here, we provide evidence for enzymatic and cellular properties of these three hydrolytic enzymes. Using the respective single, double and triple deletion mutants and strains overexpressing the three enzymes, we demonstrate that each SE hydrolase exhibits certain substrate specificity. Interestingly, disturbance in SE mobilization also affects sterol biosynthesis in a type of feedback regulation. Sterol intermediates stored in SE and set free by SE hydrolases are recycled to the sterol biosynthetic pathway and converted to the final product, ergosterol. This recycling implies that the vast majority of sterol precursors are transported from lipid particles to the endoplasmic reticulum, where sterol biosynthesis is completed. Ergosterol formed through this route is then supplied to its subcellular destinations, especially the plasma membrane. Only a minor amount of sterol precursors are randomly distributed within the cell after cleavage from SE. Conclusively, SE storage and mobilization although being dispensable for yeast viability contribute markedly to sterol homeostasis and distribution.

  19. Comparative analysis of LytS/LytTR-type histidine kinase/response regulator systems in γ-proteobacteria.

    Stefan Behr

    Full Text Available Bacterial histidine kinase/response regulator systems operate at the interface between environmental cues and physiological states. Escherichia coli contains two LytS/LytTR-type histidine kinase/response regulator systems, BtsS/BtsR (formerly YehU/YehT and YpdA/YpdB, which have been identified as pyruvate-responsive two-component systems. Since they exhibit remarkable similarity, we analyzed their phylogenetic distribution within the γ-proteobacteria, and experimentally characterized them in a set of representative species. We found that BtsS/BtsR is the predominant LytS/LytTR-type two-component system among γ-proteobacteria, whereas YpdA/YpdB primarily appears in a supplementary role. Based on our observations in E. coli, we used the highly conserved DNA-binding motifs to test the in vivo functionality of both systems in various genera, including Salmonella, Enterobacter, Citrobacter, Xenorhabdus, Yersinia, Aeromonas and Vibrio. The results suggest that, in all cases tested, BtsS/BtsR and YpdA/YpdB respond to different levels of pyruvate in the environment.

  20. Diamond lemma for the group graded quasi-algebras

    Author Affiliations. MAMTA BALODI1 HUA-LIN HUANG2 SHIV DATT KUMAR1. Department of Mathematics, Motilal Nehru National Institute of Technology, Allahabad 211 004, India; School of Mathematics, Shandong University, Jinan 250100, China ...

  1. The Genetic Structure of Milkfish (Chanos chanos) Stocks from ...

    Yudha T Adiputra

    2012-02-14

    Feb 14, 2012 ... Genetic diversity of Indonesia milkfish (Chanos chanos) using amplified ... into fish populations in a wide range of applications. (Verspoor ... The quality of extracted DNA was ..... egg, larval and adult stages (Lin et al., 2009).

  2. Dicty_cDB: Contig-U12032-1 [Dicty_cDB

    Full Text Available iviii*fyn*kkdqk ielvvllicivil*gdnnkl*iinyk**iinnnnk*yyi*kikf*k*ikk Frame C: lin**...l *lksil*tqi*knntlnwvvywvkv*cf*ihqpidnvkp*pyqsienlvplknvaksvvi lmncyiiyiilivvvpiilv*nvqskk*plis*iifkdlgqitsl

  3. African Journal of Biotechnology - Vol 12, No 31 (2013)

    induced fatty liver model of consecutive extracts from Rosa davurica Pall · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Ying Wei, Muyi Cai, Ruizeng Gu, Jun Lu, Feng Lin, Baoping Ji ...

  4. Prevalence of clinical benign prostatic hyperplasia amongst ...

    R.W. Ojewola

    2017-04-29

    Apr 29, 2017 ... Subjects and methods: This is a community-based cross-sectional survey conducted ... and BPH among countries, possibly arising from cultural or lin- ..... reported prevalence 21.0% in Jeju Island, South Korea [5] and of.

  5. Quick insulin radioimmunoassay and its utilization for intra operative localization of insulinoma

    Ursich, M.J.M.; Fukui, R.T.; Aguiar Pupo, A. de; Machado, M.C.C.

    1988-01-01

    A quick insuLin radioimmunoassay performed in 90 minutes is described and the results are compared with those obtained with the conventional method. The realibility of the new procedure is pointed. (M.A.C.) [pt

  6. Remediation of Aqueous Solution of Cypermethrin and ...

    ADOWIE PERE

    Curcas can be effective in the adsorption of these two pesticides from water bodies. Equilibrium experiment results ... and electro-Fenton , combined ultrasound and Fenton. (Ma et al, 2010), ..... Desalination, 250, 450-455 492. Chang, K; Lin, J ...

  7. Hans-Dieter Kreuder. Metasprachliche Lexikographie ...

    rbr

    Kreuder's study specifically describes the history and development of lin- .... the First International Linguistic Conference in The Hague in 1928, this effort of linguists to ..... rules and good communication to ensure consistent treatment of the.

  8. Culture as a Probiotic

    pc

    2012-04-12

    Apr 12, 2012 ... effects of kefir were studied on human beings (Lin and. Change, 2000; Hoolihan, 2001; ... composition, reduced malformations and improved gut morphology and ..... Disinfection of Gilthead Sea Bream. (Sparus aurata), Red ...

  9. Journal of Biosciences | Indian Academy of Sciences

    De Tian1 Lin Guo1. Orthopedics Department, Hospital of Dalian University, Dalian 116 001, China; School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, China; The Nursing Department, Affiliated Zhongshan ...

  10. Trochanteric bursitis

    ... of the hip; Hip bursitis References Fredericson M, Lin C, Chew K. Greater trochanteric pain syndrome. In: ... Shoulder Service, UCSF Department of Orthopaedic Surgery, San Francisco, CA. Also reviewed by David Zieve, MD, MHA, ...

  11. Government Expenditure, Efficiency and Economic Growth: A Panel ...

    Choong Chee Keong. 6 and Lau Lin Sea. 7 ... Corresponding Author, Department of Economics, Faculty of Business and Finance, UTAR, Malaysia. .... the taxation system and assert that if country's government expenditure is greater than.

  12. Näitus "Eesti kirjanik karikatuuris" = Exhibition "Estonian writers in caricature"

    2011-01-01

    linäitus pälvis Eesti Sisearhitektide Liidu 2010. a. näituse ja installatsiooni kujunduse preemia. Autorid: Kaarel Vahtramäe, Liina Jakobson, Mart Lankots, Janno Siimar (Velvet Creative Alliance)

  13. Outdoor fitness routine

    ... on a sport you enjoy, such as bicycling, hiking, jogging, rowing, tennis, or Frisbee. Make chores a ... L, Lin BB, Gaston KJ, Fuller RA. The benefits of natural environments for physical activity. Sports Med . ...

  14. Proceedings – Mathematical Sciences | Indian Academy of Sciences

    Author Affiliations. Wenhua Gao1 Lin Tang2. School of Applied Mathematics, Beijing Normal University Zhuhai, Zhuhai 519085, People's Republic of China; LMAM, School of Mathematical Sciences, Peking University, Beijing 100871, People's Republic of China ...

  15. African Journal of Biotechnology - Vol 11, No 69 (2012)

    In silico comparative analysis of EST-SSRs in three cotton genomes · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Daojun Yuan, Shaoguang Liang, Zhongxu Lin, Xianlong Zhang, 13269-13371 ...

  16. ORIGINAL ARTICLE

    TB which relies heavily on culture and phenotypic. DST are ... strains from East Asian Lineage and Beijing sub lin- eage acquire DR ...... Indian Journal of Chest Diseases & Allied Sci- ence ... Southeast Asian Journal of Tropical Medicine and.

  17. Survey of Internet Use as a Source of Health-Related Information in ...

    relationship between Internet use and socio-demographic variables. ... the effect of socio-demographic variables on. Internet use. ... Statistical Package for Social Science. (SPSS .... Lin CA. Perceived Gratifications of Online Media Services.

  18. Pramana – Journal of Physics | Indian Academy of Sciences

    Author Affiliations. Yang Xian-Lin1 2 Tang Jia-Shi1. College of Mechanics and Aerospace, Hunan University, Changsha, Hunan 410082, China; Hunan Radio and Television University, Changsha, Hunan 410004, China ...

  19. Surface Turbulent Fluxes, 1x1 deg Monthly Climatology, Set1 and NCEP V2c

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-2c Dataset recently produced through a MEaSURES funded project led by Dr. Chung-Lin Shie...

  20. Surface Turbulent Fluxes, 1x1 deg Yearly Climatology, Set1 and NCEP V2c (GSSTFYC) at GES DISC

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-2c Dataset recently produced through a MEaSURES funded project led by Dr. Chung-Lin Shie...

  1. Surface Turbulent Fluxes, 1x1 deg Monthly Climatology, Set1 and NCEP V2c (GSSTFMC) at GES DISC

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-2c Dataset recently produced through a MEaSURES funded project led by Dr. Chung-Lin Shie...

  2. Surface Turbulent Fluxes, 1x1 deg Monthly Grid, Set1 and Interpolated Data V2c (GSSTFM) at GES DISC

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-2c Dataset recently produced through a MEaSUREs funded project led by Dr. Chung-Lin Shie...

  3. Surface Turbulent Fluxes, 1x1 deg Monthly Grid, Set1 and Interpolated Data V2c

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-2c Dataset recently produced through a MEaSUREs funded project led by Dr. Chung-Lin Shie...

  4. Surface Turbulent Fluxes, 1x1 deg Yearly Climatology, Set1 and NCEP V2c

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-2c Dataset recently produced through a MEaSURES funded project led by Dr. Chung-Lin Shie...

  5. Young Children's Mathematics References during Free Play in Family Childcare Settings

    Hendershot, Shawnee M.; Berghout Austin, Ann M.; Blevins-Knabe, Belinda; Ota, Carrie

    2016-01-01

    Very little is known about children's discussion of mathematics topics during unstructured play. Ginsburg, Lin, Ness, and Seo [2003. Young American and Chinese children's everyday mathematical activity. Mathematical Thinking and Learning, 5(4), 235-258. Retrieved from…

  6. Generic UAV Modeling to Obtain Its Aerodynamic and Control Derivatives

    Chua, Choon S

    2008-01-01

    .... The first approach explored in this thesis involves using the LinAir software program developed about a decade ago at Stanford University, the second one relies on the Athena Vortex Lattice package...

  7. Use of shell model calculations in R-matrix studies of neutron-induced reactions

    Knox, H.D.

    1986-01-01

    R-matrix analyses of neutron-induced reactions for many of the lightest p-shell nuclei are difficult due to a lack of distinct resonance structure in the reaction cross sections. Initial values for the required R-matrix parameters, E,sub(lambda) and γsub(lambdac) for states in the compound system, can be obtained from shell model calculations. In the present work, the results of recent shell model calculations for the lithium isotopes have been used in R-matrix analyses of 6 Li+n and 7 Li+n reactions for E sub(n) 7 Li and 8 Li on the 6 Li+n and 7 Li+n reaction mechanisms and cross sections are discussed. (author)

  8. 76 FR 554 - Ocean Transportation Intermediary License Applicants

    2011-01-05

    ... Western Way, Torrance, CA 90501. Officer: Hseanru aka Stephen H. Lin, President/VP/Secretary/CFO... Street, Lyndhurst, NJ 07071. Officers: Jerry Wang, Vice President (Qualifying Individual), Loong H. Chang...

  9. Unedited Version

    5

    Patient with Familial Norrie Disease: Bilateral Blindness and Leucocoria ..... Lin RC, Shih JC (2013) Monoamine oxidase A and A/B knockout mice display autistic-like ... spectrum in familial exudative vitreoretinopathy and Norrie disease with ...

  10. Festivalivaip läks Hiinasse / Anu Saare

    Saare, Anu, 1964-

    2000-01-01

    Neljateistkümnenda Pärnu rahvusvahelise dokumentaal- ja antropoloogiafilmide festivalil peaauhinna saanud hiinlase Pu Lin Wen'i filmist "Otsides Shangri La'd". Ka teistest auhinnatud filmidest ning nende nimekiri

  11. CrossTalk: The Journal of Defense Software Engineering. Volume 21, Number 9

    Cook, Steve; Lin, Calvin; Chang, Walter; Hansson, Joergen; Feiler, Peter H; Morley, John; Howard, Michael; Pal, Partha; Atighetchi, Michael; Goertzel, Karen M; Cunha, Corey P

    2008-01-01

    .... Calvin Lin, and Walter Chang: Describes an extensible, compiler-based system to ensure that C programs enforce a wide variety of user-defined security policies with a minimum of runtime overhead and disruption to development processes. 2...

  12. 76 FR 76411 - Ocean Transportation Intermediary License; Applicants

    2011-12-07

    ... Avenue, Apt. A, Monterey Park, CA 91755-2044, Officers: Li Lin, General Manager/Sec/CFO, (Qualifying.... Suddath Global Logistics, LLC dba Suddath Global Logistics, (NVO & OFF), 815 South Main Street...

  13. Generalized Extreme Value model with Cyclic Covariate Structure ...

    48

    enhances the estimation of the return period; however, its application is ...... Cohn T A and Lins H F 2005 Nature's style: Naturally trendy; GEOPHYSICAL ..... Final non-stationary GEV models with covariate structures shortlisted based on.

  14. Goddard Satellite-Based Surface Turbulent Fluxes Climatology, Yearly Grid V3

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-3 Dataset recently produced through a MEaSUREs funded project led by Dr. Chung-Lin Shie...

  15. Goddard Satellite-Based Surface Turbulent Fluxes Climatology, Seasonal Grid V3

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-3 Dataset recently produced through a MEaSUREs funded project led by Dr. Chung-Lin Shie...

  16. The sounds of Chinese and how to teach them

    Třísková, Hana

    2008-01-01

    Roč. 76, č. 4 (2008), s. 509-544 ISSN 0044-8699 Institutional research plan: CEZ:AV0Z90210515 Keywords : Mandarin * phonetics * phonology * teaching * pronunciation * Yen-Hwei Lin Subject RIV: AI - Linguistics

  17. SELES

    Garcia-Zamora, Claudia; Rodriguez-Henriquez, Francisco; Ortiz-Arroyo, Daniel

    2005-01-01

    In this paper we present an improved e-voting protocol for online elections based on the scheme proposed by Lin--Hwang--Chang. We show that Lin--Hwang--Chang's scheme has two important weaknesses. We describe in detail our findings and propose a new scheme to overcome these weaknesses effectively....... To test our protocol, we implemented a distributed e-voting system. Finally we evaluate and compare our protocol with other previously proposed schemes....

  18. Protecting Networks Via Automated Defense of Cyber Systems

    2016-09-01

    gray-hats/. 61 Hu, Youfan, Yan Zhang, Chen Xu, Long Lin, Robert L. Snyder, and Zhong Lin Wang. “Self-Powered System with Wireless Data Transmission ...wires will almost completely cease to exist, replaced by mobile nanodevices, which are tiny computers measured in nanometers with integrated wireless ... energy companies, was hypothesized to cost $10,000. Raiu went on to opine, “The cost of entry for [advanced persistent threats] is decreasing …. We’re

  19. Production of 48V in a nuclear reactor via secondary tritons

    Siri, S.; Cohen, I.M.

    2009-01-01

    The production of 48 V in a nuclear reactor, induced on titanium by tritons generated from the 6 Li(n, t) 4 He reaction, and eventually 7 Li(n, n't) 4 He, is described. Samples of lithium titanate were irradiated for an irradiation cycle (120 h) in the RA-3 reactor, belonging to Ezeiza Atomic Centre. After a radiochemical separation, the characteristic radiations from 48 V were identified in the gamma ray spectra of the vanadium fractions. (orig.)

  20. Algorithms for Large-Scale Astronomical Problems

    2013-08-01

    Magana, Ross O’Connell, Xiaoying Xu, and Feng Yu . They are very nice and provided a lot of useful information. During these years I have worked with...Sicun Gao, Fan Guo, Yunchuan Kong, Ni Lao, Lei Li, Nan Li, Jialiu Lin, Yuefeng Lin, Xi Liu, Ning Lu, Min Luo, Kai Ren, Chao Shen, Long Qin, Huimin... Hsieh , Deborah A. Wallach, Mike Burrows, Tushar Chandra, Andrew Fikes, and Robert E. Gruber. Bigtable: A distributed storage system for structured data

  1. Unbiased Combinatorial Genomic Approaches to Identify Alternative Therapeutic Targets within the TSC Signaling Network

    2015-09-01

    endonuclease. Nat Biotechnol. 2013;31(3):230-2. Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N, et al. Multiplex genome engineering using CRISPR/Cas systems...Res 42, e89 (2014)10.1093/nar/gku289). 13. L. Cong, F. A. Ran, D. Cox, S. Lin, R. Barretto, N. Habib , P. D. Hsu, X. Wu, W. Jiang, L. A. Marraffini

  2. RLE (Research Laboratory of Electronics) Progress Report Number 130

    1988-07-01

    Ippen, James G. Fujimoto, Wei-Zhu Lin, Beat Zysset, Robert W. Schoenlein, 4 Michael J. Lagasse The investigation of transient carrier dynamics in GaAs...G. Fujimoto, Wei-Zhu Lin, Reginald Birngruber, Beat Zysset, Robert W. Schoenleln Working in collaboration with researchers at the Massachusetts Eye... Binaural Hearing National Institutes of Health (Grant 5 RO 1 NS 10916) H. Steven Colburn, Nathaniel 1. Durlach, Patrick M. Zurek 17 Brooklyn College14 141

  3. Impulse Response of the Exchange Rate Volatility to a Foreign Exchange Intervention Shock

    Hoshikawa, Takeshi

    2009-01-01

    This paper uses Lin's technique (1997) to report on the impulse response function analysis that traces the dynamics of exchange rate volatility from innovations in Japanese foreign exchange intervention. Using a multivariate GARCH model, we employed a volatility impulse response function based on Lin (1997) to detect the impulse response of exchange rate volatility on a one-unit foreign exchange intervention shock. The main findings of t his paper are as follows: (1) a foreign exchange inter...

  4. Classifying chemical mode of action using gene networks and machine learning: a case study with the herbicide linuron.

    Ornostay, Anna; Cowie, Andrew M; Hindle, Matthew; Baker, Christopher J O; Martyniuk, Christopher J

    2013-12-01

    The herbicide linuron (LIN) is an endocrine disruptor with an anti-androgenic mode of action. The objectives of this study were to (1) improve knowledge of androgen and anti-androgen signaling in the teleostean ovary and to (2) assess the ability of gene networks and machine learning to classify LIN as an anti-androgen using transcriptomic data. Ovarian explants from vitellogenic fathead minnows (FHMs) were exposed to three concentrations of either 5α-dihydrotestosterone (DHT), flutamide (FLUT), or LIN for 12h. Ovaries exposed to DHT showed a significant increase in 17β-estradiol (E2) production while FLUT and LIN had no effect on E2. To improve understanding of androgen receptor signaling in the ovary, a reciprocal gene expression network was constructed for DHT and FLUT using pathway analysis and these data suggested that steroid metabolism, translation, and DNA replication are processes regulated through AR signaling in the ovary. Sub-network enrichment analysis revealed that FLUT and LIN shared more regulated gene networks in common compared to DHT. Using transcriptomic datasets from different fish species, machine learning algorithms classified LIN successfully with other anti-androgens. This study advances knowledge regarding molecular signaling cascades in the ovary that are responsive to androgens and anti-androgens and provides proof of concept that gene network analysis and machine learning can classify priority chemicals using experimental transcriptomic data collected from different fish species. © 2013.

  5. Population structure and biological characteristics of Siriella gracilis (Mysida) from the Exclusive Economic Zone of India

    Biju, A.; Honey, U.K.; Kusum, K.K.; Jagadeesan, L.

    di ffe re nt se as o n s St at io n n o . La tit ud e (°N ) Lo ng itu de (°E ) IM S (20 04 ) SW M (20 05 ) N EM (20 06 ) S. gr a ci lis Te m pe ra tu re Sa lin ity S. gr a ci lis Te m pe ra tu re Sa lin ity S. gr a ci lis Te m pe ra tu re Sa lin ity... 04 ) SW M (20 05 ) N EM (20 06 ) S. gr a ci lis Te m pe ra tu re Sa lin ity S. gr a ci lis Te m pe ra tu re Sa lin ity S. gr a ci lis Te m pe ra tu re Sa lin ity de ns ity (°C ) de ns ity (°C ) de ns ity (°C ) 27 15 72 – 29 .7 35 .0 – 30 .7 35 .9...

  6. A mutation in a coproporphyrinogen III oxidase gene confers growth inhibition, enhanced powdery mildew resistance and powdery mildew-induced cell death in Arabidopsis.

    Guo, Chuan-yu; Wu, Guang-heng; Xing, Jin; Li, Wen-qi; Tang, Ding-zhong; Cui, Bai-ming

    2013-05-01

    A gene encoding a coproporphyrinogen III oxidase mediates disease resistance in plants by the salicylic acid pathway. A number of genes that regulate powdery mildew resistance have been identified in Arabidopsis, such as ENHANCED DISEASE RESISTANCE 1 to 3 (EDR1 to 3). To further study the molecular interactions between the powdery mildew pathogen and Arabidopsis, we isolated and characterized a mutant that exhibited enhanced resistance to powdery mildew. The mutant also showed dramatic powdery mildew-induced cell death as well as growth defects and early senescence in the absence of pathogens. We identified the affected gene by map-based cloning and found that the gene encodes a coproporphyrinogen III oxidase, a key enzyme in the tetrapyrrole biosynthesis pathway, previously known as LESION INITIATION 2 (LIN2). Therefore, we designated the mutant lin2-2. Further studies revealed that the lin2-2 mutant also displayed enhanced resistance to Hyaloperonospora arabidopsidis (H.a.) Noco2. Genetic analysis showed that the lin2-2-mediated disease resistance and spontaneous cell death were dependent on PHYTOALEXIN DEFICIENT 4 (PAD4), SALICYLIC ACID INDUCTION-DEFICIENT 2 (SID2), and NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1), which are all involved in salicylic acid signaling. Furthermore, the relative expression levels of defense-related genes were induced after powdery mildew infection in the lin2-2 mutant. These data indicated that LIN2 plays an important role in cell death control and defense responses in plants.

  7. Electromagnetic analysis of ITER generic equatorial port plug designs during three plasma current disruption cases

    Guirao, J.; Rodríguez, E.; Ordieres, J.; Cabanas, M.F.; García, C.H. Rojas

    2012-01-01

    Highlights: ► Electromagnetic transient performance evaluation of the GEPP structure. ► Three different plasma current disruption cases: MD UP LIN36, VDE UP LIN36 and VDE DW LIN36 were analyzed. ► Three DSM-First Wall (FW) designs (horizontal and vertical drawers and monoblock) were compared. - Abstract: Electromagnetic phenomena due to plasma current disruptions are the cause for the main mechanical operation loads over the ITER equatorial level port plug structures. This paper presents a detailed finite element simulation and analysis of the transient electromagnetic effects of three different plasma current disruption cases over three designs of diagnostic shielding module (DSM) structure. The DSMs are contained into and supported by the generic equatorial port plug (GEPP) analyzed structure. The three plasma disruption cases studied were: major disruption upwards linear decay in 36 ms (MD UP LIN36), vertical displacements events, upwards and downwards linear decay in 36 ms (VDE UP LIN36 and VDE DW LIN36). A detailed analysis for GEPP structure and three DSM-first wall (FW) designs (horizontal and vertical drawers and monoblock) is also presented in order to extract the Eddy current distribution on these devices and thus the resultant electromagnetic forces and moments acting on them.

  8. A developmental timing switch promotes axon outgrowth independent of known guidance receptors.

    Katherine Olsson-Carter

    2010-08-01

    Full Text Available To form functional neuronal connections, axon outgrowth and guidance must be tightly regulated across space as well as time. While a number of genes and pathways have been shown to control spatial features of axon development, very little is known about the in vivo mechanisms that direct the timing of axon initiation and elongation. The Caenorhabditis elegans hermaphrodite specific motor neurons (HSNs extend a single axon ventrally and then anteriorly during the L4 larval stage. Here we show the lin-4 microRNA promotes HSN axon initiation after cell cycle withdrawal. Axons fail to form in lin-4 mutants, while they grow prematurely in lin-4-overexpressing animals. lin-4 is required to down-regulate two inhibitors of HSN differentiation--the transcriptional regulator LIN-14 and the "stemness" factor LIN-28--and it likely does so through a cell-autonomous mechanism. This developmental switch depends neither on the UNC-40/DCC and SAX-3/Robo receptors nor on the direction of axon growth, demonstrating that it acts independently of ventral guidance signals to control the timing of HSN axon elongation.

  9. Encyclopedia of Information Ethics and Security

    Reviewed by Yavuz AKBULUT

    2008-01-01

    /Dick Whiddett, Inga Hunter,Judith Engelbrecht, and Jocelyn Handy Privacy and Online Data Collection/Cãlin Gurãu Privacy in Data Mining Textbooks/James Lawler and John C. Molluzzo Protection of Mobile Agent Data/Sheng-Uei Guan Rule-Based Policies for Secured Defense Meetings/Pravin Shetty and Seng Loke Secure Agent Roaming under M-Commerce/Sheng-Uei Guan Secure Automated Clearing House Transactions/Jan Skalicky Hanson and MarkB. Schmidt Security Dilemmas for Canada‘s New Government/Jeffrey Roy Security Model for Educational Satellite Networks/Sanjay Jasola and Ramesh C.Sharma Security of Communication and Quantum Technology/Gregory Paperin Security Protection for Critical Infrastructure/M. J. Warren and T. B. Busuttil Spyware/Thomas F. Stafford Sustainable Information Society/Ralf Isenmann Taxonomy of Computer and Information Ethics/Sabah S. Al-Fedaghi Tools for Representing and Processing Narratives/Ephraim Nissan Traditional Knowledge and Intellectual Property/Ulia Popova-Gosart Universal Internet Access under an Ethical Lens/Alessandro Arbore

  10. 專論/台灣圖書館史數位圖書館建構之研究/王梅玲;蔡明月;陳志銘;柯雲娥;蔡佳縈;陳勇汀;林怡甄 | A Digital Library Pilot Study on Taiwan Libraries' History / Mei-Ling Wang; Ming-Yueh Tsay; Chih-Ming Chen; Yun-Er Ke; Chia-Ying Tsai; Yong-Ting Chen; Yi-Jen Lin

    王梅玲、蔡明月、陳志銘、柯雲娥、蔡佳縈、陳勇汀、林怡甄

    2008-04-01

    Full Text Available

    圖書館是保存與詮釋人類文化重要的機構,1990 年代開始,網際網路的進步,促成數位圖書館蓬勃發展,有人預測它就是未來的圖書館,因此,圖書館界與教育界積極參與相關研究。台灣地區歷經日據時期、重建 時期、成長時期及茁壯時期四階段,建設許多圖書館,有其豐富的主題與素材值得發展成為數位圖書館。政治大學圖書資訊與檔案學研究所有鑑於此,提出「『台灣 百無圖書館史』數位圖書館」的構想,並獲得政大「發展國際一流大學及頂尖研究中心計畫」經費支持。本研究計畫目的包括:(1探索以台彎圖書館事業史為主 題的數位圖書館建構模式;(2建構數位圖書館以支援圖書資訊學教育與研究;(3研訂圖書館事業史料文獻的Metadata與數位資料格式;(4將圖 書文獻與文物數位化以建構數位館藏;(5發展數位圖書館系統與技術;(6研發數位圖書館網站的瀏覽與檢索功能;(7探討數位圖書館支援數位學習的模 式。計畫成果共研訂六種 Metadata標準:建置746筆數位化資料;以Dspace系統平台,依據需求設計台灣百年圖書館史系統架構與網站,最後提出結論與建議。

    Libraries are important social institutions that preserve and communicate human culture and knowledge. From the beginning of 1990s, the digital library has grown up rapidly based on the progress of the Internet. Libraries and educational institutions should be actively involved in digital library research and development. The Taiwan libraries’ history can be divided into four stages: Japanese occupation period, reconstruction period, growth period and strong period. In these processes, many events and libraries with rich materials that can be developed into a digital library. Graduate Institute of Library, Information and Archival Studies, National Chengchi University, planned the Digital Library Pilot Study on Taiwan Libraries’ History and got the university support. The pilot study objectives include: (1 exploring the digital library model on Taiwan libraries' history; (2 constructing digital library to support education and research in information and library science; (3 developing Metadata standards of library documents and heritage; (4 digitalizing documents and heritage to build digital collections (5 developing digital library systems and technology; (6 researching browsing and search functions of the digital library; (7 exploring the model of the digital library supports e-learning. In this pilot study, we developed six Metadata standards, built 746 digital resources, constructed a digital library system and web site, and proposed the conclusions and suggestions finally.

    頁次:15-38

  11. Stress Survival Islet 2, Predominantly Present in Listeria monocytogenes Strains of Sequence Type 121, Is Involved in the Alkaline and Oxidative Stress Responses.

    Harter, Eva; Wagner, Eva Maria; Zaiser, Andreas; Halecker, Sabrina; Wagner, Martin; Rychli, Kathrin

    2017-08-15

    The foodborne pathogen Listeria monocytogenes is able to survive a variety of stress conditions leading to the colonization of different niches like the food processing environment. This study focuses on the hypervariable genetic hot spot lmo0443 to lmo0449 haboring three inserts: the stress survival islet 1 (SSI-1), the single-gene insert LMOf2365_0481 , and two homologous genes of the nonpathogenic species Listeria innocua : lin0464 , coding for a putative transcriptional regulator, and lin0465 , encoding an intracellular PfpI protease. Our prevalence study revealed a different distribution of the inserts between human and food-associated isolates. The lin0464-lin0465 insert was predominantly found in food-associated strains of sequence type 121 (ST121). Functional characterization of this insert showed that the putative PfpI protease Lin0465 is involved in alkaline and oxidative stress responses but not in acidic, gastric, heat, cold, osmotic, and antibiotic stresses. In parallel, deletion of lin0464 decreased survival under alkaline and oxidative stresses. The expression of both genes increased significantly under oxidative stress conditions independently of the alternative sigma factor σ B Furthermore, we showed that the expression of the protease gene lin0465 is regulated by the transcription factor lin0464 under stress conditions, suggesting that lin0464 and lin0465 form a functional unit. In conclusion, we identified a novel stress survival islet 2 (SSI-2), predominantly present in L. monocytogenes ST121 strains, beneficial for survival under alkaline and oxidative stresses, potentially supporting adaptation and persistence of L. monocytogenes in food processing environments. IMPORTANCE Listeria monocytogenes strains of ST121 are known to persist for months and even years in food processing environments, thereby increasing the risk of food contamination and listeriosis. However, the molecular mechanism underlying this remarkable niche-specific adaptation

  12. Improving Oil Recovery (IOR) with Polymer Flooding in a Heavy-Oil River-Channel Sandstone Reservoir

    Lu, Hongjiang

    2009-01-01

    Most of the old oil fields in China have reached high water cut stage, in order to meet the booming energy demanding, oil production rate must be kept in the near future with corresponding IOR (Improving Oil Recovery) methods. Z106 oilfield lies in Shengli Oilfields Area at the Yellow River delta. It was put into development in 1988. Since the oil belongs to heavy oil, the oil-water mobility ratio is so unfavourable that water cut increases very quickly. Especially for reservoir Ng21, the san...

  13. Microfluidics as a tool for micro-manipulation

    Potgieter, S

    2008-10-01

    Full Text Available , exists (Xia & Whitesides, 1998). PDMS (Dow Corning Sylgard 184) will be poured into the moulds and cured to create the flow channels. Channel dimensions in the order of 100 µm deep and 100 µm wide will be used initially. To visualise particle.... DUFFY, D.C., MCDONALD, J.C., SCHUELLER, O.J.A., WHITESIDES, G.M. “Rapid prototyping of microfluidic systems in poly(dimethylsiloxane)”, Analytical Chemistry, 70, pp. 4974 – 4984, 1998. LIU, L., CAO, W., WU, J., WEN, W., CHANG, D.C., SHENG, P...

  14. An Efficient PageRank Approach for Urban Traffic Optimization

    Florin Pop

    2012-01-01

    to determine optimal decisions for each traffic light, based on the solution given by Larry Page for page ranking in Web environment (Page et al. (1999. Our approach is similar with work presented by Sheng-Chung et al. (2009 and Yousef et al. (2010. We consider that the traffic lights are controlled by servers and a score for each road is computed based on efficient PageRank approach and is used in cost function to determine optimal decisions. We demonstrate that the cumulative contribution of each car in the traffic respects the main constrain of PageRank approach, preserving all the properties of matrix consider in our model.

  15. Approximate discrete time analysis of the hybrid Token-CDMA MAC system

    Liu, YS

    2007-09-01

    Full Text Available Force (I.E.T.F.), July 1999 Principal Author: Mr. Yi-Sheng Liu attained his BScEng degree in March 2001 and MScEng degree with Cum Laude in December 2003 in the School of Electrical, Electronic and Computer Engineering at the University of Natal... of the Centre for Radio Access Technology (CRAT) at the same university. He holds a BScEng with first class honours in Electrical Engineering from Manchester University and a PhD degree from Cambridge, United Kingdom. His research interests are in the general...

  16. Characteristics and Functionalities of Natural and Bioinspired Nanomaterials

    2012-05-01

    Phytomedicine 2002, 9, 560-565. 24. Shen, C. C.; Tsai, S. Y.; Wei, S. L.; Wang, S. T.; Shieh, B. J., et al., Flavonoids isolated from Draconis...from Panax notoginseng using human platelet extraction and HPLC -DAD-ESI-MS/MS. J. Sep. Sci. 2008, 31, 1173-1180. 35. Wang, J.; Xu, J.; Zhong, J. B...339, 131-153. 59. Xin, H. L.; Wu, Y. C.; Su, Y. H.; Sheng, J. Y.; Ling, C. Q., Novel flavonoids from the leaves of Actinidia valvata Dunn

  17. Sustained release of bactericidal concentrations of penicillin in the pleural space via an antibiotic-eluting pigtail catheter coated with electrospun nanofibers: results from in vivo and in vitro studies

    Chao, Yin-Kai; Lee, Cheng-Hung; Liu, Kuo-Sheng; Wang, Yi-Chuan; Wang, Chih-Wei; Liu, Shih-Jung

    2015-01-01

    Yin-Kai Chao,1 Cheng-Hung Lee,2 Kuo-Sheng Liu,1 Yi-Chuan Wang,3 Chih-Wei Wang,4 Shih-Jung Liu3 1Department of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital-Linkou, College of Medicine, Chang Gung University, Taoyuan, Taiwan; 2Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Linkou, College of Medicine, Chang Gung University, Taoyuan, Taiwan; 3Department of Mechanical Engineering, Chang Gung University, Taoyuan, Taiwan; 4Department of P...

  18. REASONING OF LIBERAL ISLAM: A STUDY ON ISLAMIC PERSPECTIVES IN LIBERAL ISLAM NETWORK JAKARTA

    Yusa' Farchan

    2016-12-01

    Full Text Available The renewal of Islamic thinking continuously develops from time to time in Indonesia. This research tries to answer two main problems, they are: how are the reasoning or ideology developed by Liberal Islam Network (LIN?; and how are LIN’s main ideas and their metamorphoses? The research applies qualitative method with hermeneutic approach. The data is collected by library research or text documentation. The data is collected on August 18th to August 29th 2015. The research finds that the ideas of Liberal Islam Network show significant liberal signs. From the ontology of text, in reading religious text, LIN’s assumptions are “the critics over the truth”. LIN applies humanistic approach in reading the religious texts. This is confirmed by LIN’s defense toward human’s dignity. From the aspect of theoretically analytical tools in reading religious texts, LIN applies social sciences, which are socio-historical analyses. LIN uses symbol or semiotics analyses to read the religious text. The main notions of LIN are: First, Islam changes, it is not static; second, context is the first and history is the latter. Here, in reading a religious text, LIN wants to place context (socio-history proportionally; third, LIN intends to hold God in our ground and history. The metamorphoses of LIN’s ideas are: firstly is to oppose theocracy; secondly is to endorse democracy; thirdly is to endorse gender equality; fourthly is to contextualize religious doctrines; and fifthly is to support pluralism and freedom of thinking.

  19. The influence of BDNF on human umbilical cord blood stem/progenitor cells: implications for stem cell-based therapy of neurodegenerative disorders.

    Paczkowska, Edyta; Łuczkowska, Karolina; Piecyk, Katarzyna; Rogińska, Dorota; Pius-Sadowska, Ewa; Ustianowski, Przemysław; Cecerska, Elżbieta; Dołęgowska, Barbara; Celewicz, Zbigniew; Machaliński, Bogusław

    2015-01-01

    Umbilical cord blood (UCB)-derived stem/progenitor cells (SPCs) have demonstrated the potential to improve neurologic function in different experimental models. SPCs can survive after transplantation in the neural microenvironment and indu ce neuroprotection, endogenous neurogenesis by secreting a broad repertoire of trophic and immunomodulatory cytokines. In this study, the influence of brain-derived neurotrophic factor (BDNF) pre-treatment was comprehensively evaluated in a UCB-derived lineage-negative (Lin-) SPC population. UCB-derived Lin- cells were evaluated with respect to the expression of (i) neuronal markers using immunofluorescence staining and (ii) specific (TrkB) receptors for BDNF using flow cytometry. Next, after BDNF pre-treatment, Lin- cells were extensively assessed with respect to apoptosis using Western blotting and proliferation via BrdU incorporation. Furthermore, NT-3 expression levels in Lin- cells using RQ PCR and antioxidative enzyme activities were assessed. We demonstrated neuronal markers as well as TrkB expression in Lin- cells and the activation of the TrkB receptor by BDNF. BDNF pre-treatment diminished apoptosis in Lin- cells and influenced the proliferation of these cells. We observed significant changes in antioxidants as well as in the increased expression of NT-3 in Lin- cells following BDNF exposure. Complex global miRNA and mRNA profiling analyses using microarray technology and GSEA revealed the differential regulation of genes involved in the proliferation, gene expression, biosynthetic processes, translation, and protein targeting. Our results support the hypothesis that pre-treatment of stem/progenitor cells could be beneficial and may be used as an auxiliary strategy for improving the properties of SPCs.

  20. C. elegans microRNAs.

    Vella, Monica C; Slack, Frank J

    2005-09-21

    MicroRNAs (miRNAs) are small, non-coding regulatory RNAs found in many phyla that control such diverse events as development, metabolism, cell fate and cell death. They have also been implicated in human cancers. The C. elegans genome encodes hundreds of miRNAs, including the founding members of the miRNA family lin-4 and let-7. Despite the abundance of C. elegans miRNAs, few miRNA targets are known and little is known about the mechanism by which they function. However, C. elegans research continues to push the boundaries of discovery in this area. lin-4 and let-7 are the best understood miRNAs. They control the timing of adult cell fate determination in hypodermal cells by binding to partially complementary sites in the mRNA of key developmental regulators to repress protein expression. For example, lin-4 is predicted to bind to seven sites in the lin-14 3' untranslated region (UTR) to repress LIN-14, while let-7 is predicted to bind two let-7 complementary sites in the lin-41 3' UTR to down-regulate LIN-41. Two other miRNAs, lsy-6 and mir-273, control left-right asymmetry in neural development, and also target key developmental regulators for repression. Approximately one third of the C. elegans miRNAs are differentially expressed during development indicating a major role for miRNAs in C. elegans development. Given the remarkable conservation of developmental mechanism across phylogeny, many of the principles of miRNAs discovered in C. elegans are likely to be applicable to higher animals.