Evapotranspiration Cover for the 92-Acre Area Retired Mixed Waste Pits:Interim CQA Report

Energy Technology Data Exchange (ETDEWEB)

The Delphi Groupe, Inc., and J. A. Cesare and Associates, Inc.

2011-06-20

This Interim Construction Quality Assurance (CQA) Report is for the 92-Acre Evapotranspiration Cover, Area 5 Waste Management Division (WMD) Retired Mixed Waste Pits, Nevada National Security Site, Nevada for the period of January 20, 2011 to May 12, 2011. This Interim Construction Quality Assurance (CQA) Report is for the 92-Acre Evapotranspiration Cover, Area 5 Waste Management Division (WMD) Retired Mixed Waste Pits, Nevada National Security Site, Nevada for the period of January 20, 2011 to May 12, 2011. Construction was approved by the Nevada Division of Environmental Protection (NDEP) under the Approval of Corrective Action Decision Document/Corrective Action Plan (CADD/CAP) for Corrective Action Unit (CAU) 111: Area 5 WMD Retired Mixed Waste Pits, Nevada National Security Site, Nevada, on January 6, 2011, pursuant to Subpart XII.8a of the Federal Facility Agreement and Consent Order. The project is located in Area 5 of the Radioactive Waste Management Complex (RWMC) at the Nevada National Security Site (NNSS), formerly known as the Nevada Test Site, located in southern Nevada, approximately 65 miles northwest of Las Vegas, Nevada, in Nye County. The project site, in Area 5, is located in a topographically closed basin approximately 14 additional miles north of Mercury Nevada, in the north-central part of Frenchman Flat. The Area 5 RWMS uses engineered shallow-land burial cells to dispose of packaged waste. The 92-Acre Area encompasses the southern portion of the Area 5 RWMS, which has been designated for the first final closure operations. This area contains 13 Greater Confinement Disposal (GCD) boreholes, 16 narrow trenches, and 9 broader pits. With the exception of two active pits (P03 and P06), all trenches and pits in the 92-Acre Area had operational covers approximately 2.4 meters thick, at a minimum, in most areas when this project began. The units within the 92-Acre Area are grouped into the following six informal categories based on physical location

77 FR 10786 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Reliability...

Science.gov (United States)

2012-02-23

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Reliability and PRA; Notice of Meeting The ACRS Subcommittee on Reliability and PRA will hold a... Modeling Application Guide.'' The Subcommittee will hear presentations by and hold discussions with the NRC...

Closure Report for the 92-Acre Area and Corrective Action Unit 111: Area 5 WMD Retired Mixed Waste Pits, Nevada National Security Site, Nevada

Energy Technology Data Exchange (ETDEWEB)

NSTec Environmental Restoration

2012-02-21

This Closure Report (CR) presents information supporting closure of the 92-Acre Area, which includes Corrective Action Unit (CAU) 111, 'Area 5 WMD Retired Mixed Waste Pits.' This CR provides documentation supporting the completed corrective actions and confirmation that the closure objectives were met. This CR complies with the requirements of the Federal Facility Agreement and Consent Order (FFACO) (FFACO, 1996 [as amended March 2010]). Closure activities began in January 2011 and were completed in January 2012. Closure activities were conducted according to Revision 1 of the Corrective Action Decision Document/Corrective Action Plan (CADD/CAP) for the 92-Acre Area and CAU 111 (U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office [NNSA/NSO], 2010). The following closure activities were performed: (1) Construct an engineered evapotranspiration cover over the boreholes, trenches, and pits in the 92-Acre Area; (2) Install use restriction (UR) warning signs, concrete monuments, and subsidence survey monuments; and (3) Establish vegetation on the covers. UR documentation is included as Appendix C of this report. The post-closure plan is presented in detail in Revision 1 of the CADD/CAP for the 92-Acre Area and CAU 111, and the requirements are summarized in Section 5.2 of this document. When the next request for modification of Resource Conservation and Recovery Act Permit NEV HW0101 is submitted to the Nevada Division of Environmental Protection (NDEP), the requirements for post-closure monitoring of the 92-Acre Area will be included. NNSA/NSO requests the following: (1) A Notice of Completion from NDEP to NNSA/NSO for closure of CAU 111; and (2) The transfer of CAU 111 from Appendix III to Appendix IV, Closed Corrective Action Units, of the FFACO.

Closure Report for the 92-Acre Area and Corrective Action Unit 111: Area 5 WMD Retired Mixed Waste Pits, Nevada National Security Site, Nevada

International Nuclear Information System (INIS)

2012-01-01

This Closure Report (CR) presents information supporting closure of the 92-Acre Area, which includes Corrective Action Unit (CAU) 111, 'Area 5 WMD Retired Mixed Waste Pits.' This CR provides documentation supporting the completed corrective actions and confirmation that the closure objectives were met. This CR complies with the requirements of the Federal Facility Agreement and Consent Order (FFACO) (FFACO, 1996 (as amended March 2010)). Closure activities began in January 2011 and were completed in January 2012. Closure activities were conducted according to Revision 1 of the Corrective Action Decision Document/Corrective Action Plan (CADD/CAP) for the 92-Acre Area and CAU 111 (U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO), 2010). The following closure activities were performed: (1) Construct an engineered evapotranspiration cover over the boreholes, trenches, and pits in the 92-Acre Area; (2) Install use restriction (UR) warning signs, concrete monuments, and subsidence survey monuments; and (3) Establish vegetation on the covers. UR documentation is included as Appendix C of this report. The post-closure plan is presented in detail in Revision 1 of the CADD/CAP for the 92-Acre Area and CAU 111, and the requirements are summarized in Section 5.2 of this document. When the next request for modification of Resource Conservation and Recovery Act Permit NEV HW0101 is submitted to the Nevada Division of Environmental Protection (NDEP), the requirements for post-closure monitoring of the 92-Acre Area will be included. NNSA/NSO requests the following: (1) A Notice of Completion from NDEP to NNSA/NSO for closure of CAU 111; and (2) The transfer of CAU 111 from Appendix III to Appendix IV, Closed Corrective Action Units, of the FFACO.

75 FR 27841 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on EPR

Science.gov (United States)

2010-05-18

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on EPR The ACRS Subcommittee on EPR will hold a meeting on May 21, 2010, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open to public attendance. The agenda for...

75 FR 7633 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on EPR; Notice...

Science.gov (United States)

2010-02-22

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on EPR; Notice of Meeting The ACRS U.S. Evolutionary Power Reactor (EPR) Subcommittee will hold a....S. EPR Design Certification Document Review. The Subcommittee will gather information, analyze...

pH-induced conformational changes of AcrA, the membrane fusion protein of Escherichia coli multidrug efflux system.

Science.gov (United States)

Ip, Hermia; Stratton, Kelly; Zgurskaya, Helen; Liu, Jun

2003-12-12

The multidrug efflux system AcrA-AcrB-TolC of Escherichia coli expels a wide range of drugs directly into the external medium from the bacterial cell. The mechanism of the efflux process is not fully understood. Of an elongated shape, AcrA is thought to span the periplasmic space coordinating the concerted operation of the inner and outer membrane proteins AcrB and TolC. In this study, we used site-directed spin labeling (SDSL) EPR (electron paramagnetic resonance) spectroscopy to investigate the molecular conformations of AcrA in solution. Ten AcrA mutants, each with an alanine to cysteine substitution, were engineered, purified, and labeled with a nitroxide spin label. EPR analysis of spin-labeled AcrA variants indicates that the side chain mobilities are consistent with the predicted secondary structure of AcrA. We further demonstrated that acidic pH induces oligomerization and conformational change of AcrA, and that the structural changes are reversible. These results suggest that the mechanism of action of AcrA in drug efflux is similar to the viral membrane fusion proteins, and that AcrA actively mediates the efflux of substrates.

AECL's advanced CANDU reactor - the ACR

International Nuclear Information System (INIS)

Alizadeh, Ala; Allsop, Peter; Hedges, Ken; Hopwood, Jerry; Yu, Stephen

2003-01-01

The ACR, the next generation CANDU design, represents the next step in development of the CANDU family of designs. AECL has achieved significant incremental improvements to the mid-size CANDU 6 nuclear power plant through successive projects, both in design and in project delivery. Building on this knowledge base, AECL is continuing to adapt the CANDU design to develop the ACR. This paper summarizes the ACR design features, which include major improvements in economics, inherent safety characteristics, performance and construction methods. Aimed at producing electrical power at a capital cost significantly less than that of the current reactor designs, the ACR is an evolutionary design based on the very successful CANDU 6 reactor. The new ACR product is specifically designed to produce power at a cost competitive with other forms of power generation while achieving short construction times, improved safety, international licensability, high investor returns, and low investor risk. It achieves these targets by taking advantage of the latest advances in both pressure-tube and pressure-vessel reactor technologies and experience. The flexibility and development potential of the fuel channel approach also enables designs to be developed that address priorities identified in international long-term specification programs such as the US Department of Energy (DOE) sponsored Generation IV program and IAEA hosted INPRO program. ACR-700 can be built in 36 months with a 48 month project duration, and deliver a lifetime capacity factor in excess of 90%. Overall, the ACR design represents a balance of proven design basis and innovations to give step improvements in safety, reliability and economics. The ACR development program, now well into the detail design stage, includes parallel formal licensing in the USA and Canada. Based on the status of the ACR design and AECL's on-going experience delivering reactor projects on-time and on-budget, the first ACR could be in service by

75 FR 12804 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on EPR; Notice...

Science.gov (United States)

2010-03-17

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on EPR; Notice of Meeting The ACRS U.S. Evolutionary Power Reactor (EPR) Subcommittee will hold a... Chapters 11 and 16 of the Safety Evaluation Report with Open Items associated with the U.S. EPR Design...

The ACR Model

DEFF Research Database (Denmark)

Bec, Frederique; Rahbek, Anders Christian; Shephard, Neil

2008-01-01

This paper proposes and analyses the autoregressive conditional root (ACR) time-series model. This multivariate dynamic mixture autoregression allows for non-stationary epochs. It proves to be an appealing alternative to existing nonlinear models, e.g. the threshold autoregressive or Markov...... switching class of models, which are commonly used to describe nonlinear dynamics as implied by arbitrage in presence of transaction costs. Simple conditions on the parameters of the ACR process and its innovations are shown to imply geometric ergodicity, stationarity and existence of moments. Furthermore...

77 FR 74696 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on AP-1000...

Science.gov (United States)

2012-12-17

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on AP-1000; Notice of Meeting The ACRS Subcommittee on AP-1000 will hold a meeting on January 18, 2013, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open to public...

Repressive mutations restore function-loss caused by the disruption of trimerization in Escherichia coli multidrug transporter AcrB

Directory of Open Access Journals (Sweden)

Zhaoshuai eWang

2015-01-01

Full Text Available AcrAB-TolC and their homologs are major multidrug efflux systems in Gram-negative bacteria. The inner membrane component AcrB functions as a trimer. Replacement of Pro223 by Gly in AcrB decreases the trimer stability and drastically reduces the drug efflux activity. The goal of this study is to identify suppressor mutations that restore function to mutant AcrBP223G and explore the mechanism of function recovery. Two methods were used to introduce random mutations into the plasmid of AcrBP223G. Mutants with elevated drug efflux activity were identified, purified, and characterized to examine their expression level, trimer stability, interaction with AcrA, and substrate binding. Nine single-site repressor mutations were identified, including T199M, D256N, A209V, G257V, M662I, Q737L, D788K, P800S, and E810K. Except for M662I, all other mutations located in the docking region of the periplasmic domain. While three mutations, T199M, A209V, and D256N, significantly increased the trimer stability, none of them restored the trimer affinity to the wild type level. M662, the only site of mutation that located in the porter domain, was involved in substrate binding. Our results suggest that the function loss resulted from compromised AcrB trimerization could be restored through various mechanisms involving the compensation of trimer stability and substrate binding.

ACR-1000: Operator - based development

International Nuclear Information System (INIS)

Shalaby, B.; Alizadeh, A.

2007-01-01

Atomic Energy of Canada Limited (AECL) has adapted the successful features of CANDU * reactors to establish Generation III + Advanced CANDU Reactor T M (ACR T M) technology. The ACR-1000 T M nuclear power plant is an evolutionary product, starting with the strong base of CANDU reactor technology, coupled with thoroughly-demonstrated innovative features to enhance economics, safety, operability and maintainability. The ACR-1000 benefits from AECL's continuous-improvement approach to design, that enabled the traditional CANDU 6 product to compile an exceptional track record of on-time, on budget product delivery, and also reliable, high capacity-factor operation. The ACR-1000 engineering program has completed the basic plant design and has entered detailed pre-project engineering and formal safety analysis to prepare the preliminary (non-project-specific) safety case. The engineering program is strongly operator-based, and encompasses much more than traditional pre-project design elements. A team of utility-experienced operations and maintenance experts is embedded in the engineering team, to ensure that all design decisions, at the system and the component level, are taken with the owner-operator interest in mind. The design program emphasizes formal review of operating feedback, along with extensive operator participation in program management and execution. Design attention is paid to layout and access of equipment, to component and material selection, and to ensuring maximum ability for on-line maintenance. This enables the ACR-1000 to offer a three-year interval between scheduled maintenance outages, with a standard 21-day outage duration. SMART CANDU T M technology allows on-line monitoring and diagnostics to further enhance plant operation. Modules of the Advanced CANDU SMART technologies are already being back-fitted to current CANDU plants. As well as reviewing the ACR-1000 design features and their supporting background, the paper describes the status of

WE-AB-206-02: ACR Ultrasound Accreditation: Requirements and Pitfalls

International Nuclear Information System (INIS)

Walter, J.

2016-01-01

The involvement of medical physicists in diagnostic ultrasound imaging service is increasing due to QC and accreditation requirements. The goal of this ultrasound hands-on workshop is to demonstrate quality control (QC) testing in diagnostic ultrasound and to provide updates in ACR ultrasound accreditation requirements. The first half of this workshop will include two presentations reviewing diagnostic ultrasound QA/QC and ACR ultrasound accreditation requirements. The second half of the workshop will include live demonstrations of basic QC tests. An array of ultrasound testing phantoms and ultrasound scanners will be available for attendees to learn diagnostic ultrasound QC in a hands-on environment with live demonstrations and on-site instructors. The targeted attendees are medical physicists in diagnostic imaging. Learning Objectives: Gain familiarity with common elements of a QA/QC program for diagnostic ultrasound imaging dentify QC tools available for testing diagnostic ultrasound systems and learn how to use these tools Learn ACR ultrasound accreditation requirements Jennifer Walter is an employee of American College of Radiology on Ultrasound Accreditation.

MO-AB-207-04: ACR Update in Mammography

International Nuclear Information System (INIS)

Berns, E.

2015-01-01

A goal of an imaging accreditation program is to ensure adequate image quality, verify appropriate staff qualifications, and to assure patient and personnel safety. Currently, more than 35,000 facilities in 10 modalities have been accredited by the American College of Radiology (ACR), making the ACR program one of the most prolific accreditation options in the U.S. In addition, ACR is one of the accepted accreditations required by some state laws, CMS/MIPPA insurance and others. Familiarity with the ACR accreditation process is therefore essential to clinical diagnostic medical physicists. Maintaining sufficient knowledge of the ACR program must include keeping up-to-date as the various modality requirements are refined to better serve the goals of the program and to accommodate newer technologies and practices. This session consists of presentations from authorities in four ACR accreditation modality programs, including magnetic resonance imaging, computed tomography, nuclear medicine, and mammography. Each speaker will discuss the general components of the modality program and address any recent changes to the requirements. Learning Objectives: To understand the requirements of the ACR MR Accreditation program. The discussion will include accreditation of whole-body general purpose magnets, dedicated extremity systems well as breast MRI accreditation. Anticipated updates to the ACR MRI Quality Control Manual will also be reviewed. To understand the requirements of the ACR CT accreditation program, including updates to the QC manual as well as updates through the FAQ process. To understand the requirements of the ACR nuclear medicine accreditation program, and the role of the physicist in annual equipment surveys and the set up and supervision of the routine QC program. To understand the current ACR MAP Accreditation requirement and present the concepts and structure of the forthcoming ACR Digital Mammography QC Manual and Program

MO-AB-207-02: ACR Update in MR

International Nuclear Information System (INIS)

Price, R.

2015-01-01

A goal of an imaging accreditation program is to ensure adequate image quality, verify appropriate staff qualifications, and to assure patient and personnel safety. Currently, more than 35,000 facilities in 10 modalities have been accredited by the American College of Radiology (ACR), making the ACR program one of the most prolific accreditation options in the U.S. In addition, ACR is one of the accepted accreditations required by some state laws, CMS/MIPPA insurance and others. Familiarity with the ACR accreditation process is therefore essential to clinical diagnostic medical physicists. Maintaining sufficient knowledge of the ACR program must include keeping up-to-date as the various modality requirements are refined to better serve the goals of the program and to accommodate newer technologies and practices. This session consists of presentations from authorities in four ACR accreditation modality programs, including magnetic resonance imaging, computed tomography, nuclear medicine, and mammography. Each speaker will discuss the general components of the modality program and address any recent changes to the requirements. Learning Objectives: To understand the requirements of the ACR MR Accreditation program. The discussion will include accreditation of whole-body general purpose magnets, dedicated extremity systems well as breast MRI accreditation. Anticipated updates to the ACR MRI Quality Control Manual will also be reviewed. To understand the requirements of the ACR CT accreditation program, including updates to the QC manual as well as updates through the FAQ process. To understand the requirements of the ACR nuclear medicine accreditation program, and the role of the physicist in annual equipment surveys and the set up and supervision of the routine QC program. To understand the current ACR MAP Accreditation requirement and present the concepts and structure of the forthcoming ACR Digital Mammography QC Manual and Program

MO-AB-207-04: ACR Update in Mammography

Energy Technology Data Exchange (ETDEWEB)

Berns, E. [University of Colorado Health Science (United States)

2015-06-15

A goal of an imaging accreditation program is to ensure adequate image quality, verify appropriate staff qualifications, and to assure patient and personnel safety. Currently, more than 35,000 facilities in 10 modalities have been accredited by the American College of Radiology (ACR), making the ACR program one of the most prolific accreditation options in the U.S. In addition, ACR is one of the accepted accreditations required by some state laws, CMS/MIPPA insurance and others. Familiarity with the ACR accreditation process is therefore essential to clinical diagnostic medical physicists. Maintaining sufficient knowledge of the ACR program must include keeping up-to-date as the various modality requirements are refined to better serve the goals of the program and to accommodate newer technologies and practices. This session consists of presentations from authorities in four ACR accreditation modality programs, including magnetic resonance imaging, computed tomography, nuclear medicine, and mammography. Each speaker will discuss the general components of the modality program and address any recent changes to the requirements. Learning Objectives: To understand the requirements of the ACR MR Accreditation program. The discussion will include accreditation of whole-body general purpose magnets, dedicated extremity systems well as breast MRI accreditation. Anticipated updates to the ACR MRI Quality Control Manual will also be reviewed. To understand the requirements of the ACR CT accreditation program, including updates to the QC manual as well as updates through the FAQ process. To understand the requirements of the ACR nuclear medicine accreditation program, and the role of the physicist in annual equipment surveys and the set up and supervision of the routine QC program. To understand the current ACR MAP Accreditation requirement and present the concepts and structure of the forthcoming ACR Digital Mammography QC Manual and Program.

MO-AB-207-02: ACR Update in MR

Energy Technology Data Exchange (ETDEWEB)

Price, R. [Vanderbilt Medical Center (United States)

2015-06-15

A goal of an imaging accreditation program is to ensure adequate image quality, verify appropriate staff qualifications, and to assure patient and personnel safety. Currently, more than 35,000 facilities in 10 modalities have been accredited by the American College of Radiology (ACR), making the ACR program one of the most prolific accreditation options in the U.S. In addition, ACR is one of the accepted accreditations required by some state laws, CMS/MIPPA insurance and others. Familiarity with the ACR accreditation process is therefore essential to clinical diagnostic medical physicists. Maintaining sufficient knowledge of the ACR program must include keeping up-to-date as the various modality requirements are refined to better serve the goals of the program and to accommodate newer technologies and practices. This session consists of presentations from authorities in four ACR accreditation modality programs, including magnetic resonance imaging, computed tomography, nuclear medicine, and mammography. Each speaker will discuss the general components of the modality program and address any recent changes to the requirements. Learning Objectives: To understand the requirements of the ACR MR Accreditation program. The discussion will include accreditation of whole-body general purpose magnets, dedicated extremity systems well as breast MRI accreditation. Anticipated updates to the ACR MRI Quality Control Manual will also be reviewed. To understand the requirements of the ACR CT accreditation program, including updates to the QC manual as well as updates through the FAQ process. To understand the requirements of the ACR nuclear medicine accreditation program, and the role of the physicist in annual equipment surveys and the set up and supervision of the routine QC program. To understand the current ACR MAP Accreditation requirement and present the concepts and structure of the forthcoming ACR Digital Mammography QC Manual and Program.

MO-AB-207-01: ACR Update in CT

Energy Technology Data Exchange (ETDEWEB)

McNitt-Gray, M. [UCLA School of Medicine (United States)

2015-06-15

A goal of an imaging accreditation program is to ensure adequate image quality, verify appropriate staff qualifications, and to assure patient and personnel safety. Currently, more than 35,000 facilities in 10 modalities have been accredited by the American College of Radiology (ACR), making the ACR program one of the most prolific accreditation options in the U.S. In addition, ACR is one of the accepted accreditations required by some state laws, CMS/MIPPA insurance and others. Familiarity with the ACR accreditation process is therefore essential to clinical diagnostic medical physicists. Maintaining sufficient knowledge of the ACR program must include keeping up-to-date as the various modality requirements are refined to better serve the goals of the program and to accommodate newer technologies and practices. This session consists of presentations from authorities in four ACR accreditation modality programs, including magnetic resonance imaging, computed tomography, nuclear medicine, and mammography. Each speaker will discuss the general components of the modality program and address any recent changes to the requirements. Learning Objectives: To understand the requirements of the ACR MR Accreditation program. The discussion will include accreditation of whole-body general purpose magnets, dedicated extremity systems well as breast MRI accreditation. Anticipated updates to the ACR MRI Quality Control Manual will also be reviewed. To understand the requirements of the ACR CT accreditation program, including updates to the QC manual as well as updates through the FAQ process. To understand the requirements of the ACR nuclear medicine accreditation program, and the role of the physicist in annual equipment surveys and the set up and supervision of the routine QC program. To understand the current ACR MAP Accreditation requirement and present the concepts and structure of the forthcoming ACR Digital Mammography QC Manual and Program.

ACR-1000 design provisions for severe accidents

International Nuclear Information System (INIS)

Popov, N.K.; Santamaura, P.; Shapiro, H.; Snell, V.G.

2006-01-01

Atomic Energy of Canada Limited (AECL) developed the Advanced CANDU Reactor-700 (ACR-700) as an evolutionary advancement of the current CANDU 6 reactor. As a further advancement of the ACR design, AECL is currently developing the ACR-1000 for the Canadian and international market. The ACR-1000 is aimed at producing electrical power for a capital cost and a unit-energy cost significantly less than that of the current generation of operating nuclear plants, while achieving enhanced safety features, shorter construction schedule, high plant capacity factor, improved operations and maintenance, and increased operating life. The reference ACR-1000 plant design is based on an integrated two-unit plant, using enriched fuel and light-water coolant, with each unit having a nominal gross output of about 1200 MWe. The ACR-1000 design meets Canadian regulatory requirements and follows established international practice with respect to severe accident prevention and mitigation. This paper presents the ACR-1000 features that are designed to mitigate limited core damage and severe core damage states, including core retention within vessel, core damage termination, and containment integrity maintenance. While maintaining existing structures of CANDU reactors that provide inherent prevention and retention of core debris, the ACR-1000 design includes additional features for prevention and mitigation of severe accidents. Core retention within vessel in CANDU-type reactors includes both retention within fuel channels, and retention within the calandria vessel. The ACR-1000 calandria vessel design permits for passive rejection of decay heat from the moderator to the shield water. Also, the calandria vessel is designed for debris retention by minimizing penetrations at the bottom periphery and by accommodating thermal and weight loads of the core debris. The ACR-1000 containment is required to withstand external events such as earthquakes, tornados, floods and aircraft crashes

The AcrB efflux pump: conformational cycling and peristalsis lead to multidrug resistance.

Science.gov (United States)

Seeger, Markus A; Diederichs, Kay; Eicher, Thomas; Brandstätter, Lorenz; Schiefner, André; Verrey, François; Pos, Klaas M

2008-09-01

Antimicrobial resistance of human pathogenic bacteria is an emerging problem for global public health. This resistance is often associated with the overproduction of membrane transport proteins that are capable to pump chemotherapeutics, antibiotics, detergents, dyes and organic solvents out of the cell. In Gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa, tripartite multidrug efflux systems extrude a large variety of cytotoxic substances from the cell membrane directly into the medium bypassing the periplasm and the outer membrane. In E. coli, the tripartite efflux system AcrA/AcrB/TolC is the pump in charge of the efflux of multiple antibiotics, dyes, bile salts and detergents. The trimeric outer membrane factor (OMF) TolC forms a beta-barrel pore in the outer membrane and exhibits a long periplasmic alpha-helical conduit. The periplasmic membrane fusion protein (MFP) AcrA serves as a linker between TolC and the trimeric resistance nodulation cell division (RND) pump AcrB, located in the inner membrane acting as a proton/drug antiporter. The newly elucidated asymmetric structure of trimeric AcrB reveals three different monomer conformations representing consecutive states in a transport cycle. The monomers show tunnels with occlusions at different sites leading from the lateral side through the periplasmic porter (pore) domains towards the funnel of the trimer and TolC. The structural changes create a hydrophobic pocket in one monomer, which is not present in the other two monomers. Minocyclin and doxorubicin, both AcrB substrates, specifically bind to this pocket substantiating its role as drug binding pocket. The energy transduction from the proton motive force into drug efflux includes proton binding in (and release from) the transmembrane part. The conformational changes observed within a triad of essential, titratable residues (Asp407/Asp408/Lys940) residing in the hydrophobic transmembrane domain appear to be transduced by

ACR-1000: Enhanced response to severe accidents

International Nuclear Information System (INIS)

Popov, N.K.; Santamaura, P.; Shapiro, H.; Snell, V.G.

2006-01-01

Full text: Atomic Energy of Canada Limited (AECL) developed the Advanced CANDU Reactor-TM700 (ACR-700TM) as an evolutionary advancement of the current CANDU 6R reactor. As further advancement of the ACR design, AECL is currently developing the ACR-1000TM for the Canadian and international market. The ACR-1000 is aimed at producing electrical power for a capital cost and a unit-energy cost significantly less than that of the current generation of operating nuclear plants, while achieving shorter construction schedule, high plant capacity factor, improved operations and maintenance, increased operating life. and enhanced safety features. The reference ACR-1000 plant design is based on an integrated two-unit plant, using enriched fuel and light-water coolant, with each unit having a nominal gross output of about 1200 MWe. This paper presents the ACR-1000 features that are designed to mitigate limited core damage and severe core damage states, including core retention within vessel, core damage termination, and containment integrity maintenance. Core retention within vessel in CANDU-type reactors includes both retention within fuel channels, and retention within the calandria vessel. The moderator heavy water in the ACR-1000 calandria vessel, as in any other CANDU-type reactor, provides ample heat removal capacity in severe accidents. The ACR-1000 calandria vessel design permits for passive rejection of decay heat from the moderator to the shield water. Also, the calandria vessel will be designed for debris retention. Core damage termination is achieved by flooding of the core components with water and keeping them flooded thereafter. Successful termination can be achieved in the fuel channels, calandria vessel or calandria vault by water supply by the Long Term Cooling (LTC) pumps and by gravity feed from the Reserve Water System. The ACR-1000 containment is required to withstand external events such as earthquakes, tornados, floods and aircraft crashes. Containment

MO-AB-207-03: ACR Update in Nuclear Medicine

International Nuclear Information System (INIS)

Harkness, B.

2015-01-01

A goal of an imaging accreditation program is to ensure adequate image quality, verify appropriate staff qualifications, and to assure patient and personnel safety. Currently, more than 35,000 facilities in 10 modalities have been accredited by the American College of Radiology (ACR), making the ACR program one of the most prolific accreditation options in the U.S. In addition, ACR is one of the accepted accreditations required by some state laws, CMS/MIPPA insurance and others. Familiarity with the ACR accreditation process is therefore essential to clinical diagnostic medical physicists. Maintaining sufficient knowledge of the ACR program must include keeping up-to-date as the various modality requirements are refined to better serve the goals of the program and to accommodate newer technologies and practices. This session consists of presentations from authorities in four ACR accreditation modality programs, including magnetic resonance imaging, computed tomography, nuclear medicine, and mammography. Each speaker will discuss the general components of the modality program and address any recent changes to the requirements. Learning Objectives: To understand the requirements of the ACR MR Accreditation program. The discussion will include accreditation of whole-body general purpose magnets, dedicated extremity systems well as breast MRI accreditation. Anticipated updates to the ACR MRI Quality Control Manual will also be reviewed. To understand the requirements of the ACR CT accreditation program, including updates to the QC manual as well as updates through the FAQ process. To understand the requirements of the ACR nuclear medicine accreditation program, and the role of the physicist in annual equipment surveys and the set up and supervision of the routine QC program. To understand the current ACR MAP Accreditation requirement and present the concepts and structure of the forthcoming ACR Digital Mammography QC Manual and Program

MO-AB-207-03: ACR Update in Nuclear Medicine

Energy Technology Data Exchange (ETDEWEB)

Harkness, B. [Henry Ford Hospital System (United States)

2015-06-15

A goal of an imaging accreditation program is to ensure adequate image quality, verify appropriate staff qualifications, and to assure patient and personnel safety. Currently, more than 35,000 facilities in 10 modalities have been accredited by the American College of Radiology (ACR), making the ACR program one of the most prolific accreditation options in the U.S. In addition, ACR is one of the accepted accreditations required by some state laws, CMS/MIPPA insurance and others. Familiarity with the ACR accreditation process is therefore essential to clinical diagnostic medical physicists. Maintaining sufficient knowledge of the ACR program must include keeping up-to-date as the various modality requirements are refined to better serve the goals of the program and to accommodate newer technologies and practices. This session consists of presentations from authorities in four ACR accreditation modality programs, including magnetic resonance imaging, computed tomography, nuclear medicine, and mammography. Each speaker will discuss the general components of the modality program and address any recent changes to the requirements. Learning Objectives: To understand the requirements of the ACR MR Accreditation program. The discussion will include accreditation of whole-body general purpose magnets, dedicated extremity systems well as breast MRI accreditation. Anticipated updates to the ACR MRI Quality Control Manual will also be reviewed. To understand the requirements of the ACR CT accreditation program, including updates to the QC manual as well as updates through the FAQ process. To understand the requirements of the ACR nuclear medicine accreditation program, and the role of the physicist in annual equipment surveys and the set up and supervision of the routine QC program. To understand the current ACR MAP Accreditation requirement and present the concepts and structure of the forthcoming ACR Digital Mammography QC Manual and Program.

Impact of modules on the ACR construction schedule

International Nuclear Information System (INIS)

Choy, Ed; Elgohary, Medhat; Fairclough, Neville; Yu, Stephen; Murayama, Kouichi; Miura, Jun; Kawahata, Junichi

2003-01-01

The ACR (Advanced CANDU Reactor), developed by Atomic Energy of Canada Ltd. (AECL), is designed with constructability considerations as a major requirement during all project phases from the concept design stage to the detail design stage. For ACR-700, a project schedule of 48 months has been developed for the nth replicated unit with a 36 month construction period duration from First Concrete to Fuel Load. AECL, recognizing the immense benefit of collective experience, is partnering with Hitachi Ltd in the development of the ACR power plant design. AECL has gained valuable experience in implementing new construction methods at the Qinshan (Phase III) twin unit CANDU 6 plant in China, and Hitachi likewise has enjoyed success in modular construction of ABWRs in Japan. Utilizing these experiences, AECL is developing the ACR nuclear steam plant (NSP) and Hitachi is developing the Turbine Building. An overall construction strategy, which builds on the success of these construction methods from the nuclear power plant developments in China and Japan, has been developed for the ACR. The overall construction strategy comprises the 'Open Top' construction technique using a Very Heavy Lift crane, parallel construction activities, with extensive modularization and prefabrication. Modules and prefabrications are major features of the ACR design, resulting in an excess of 80% of Reactor Building internal work being completed as modules or as very streamlined traditional construction. This paper reviews the ACR construction strategy and provides examples of modules and how they impact on the ACR construction schedule. In conclusion, the ACR-700 is designed using the latest, proven construction methods to achieve a 36 month construction period for the nth replicated unit. (author)

ACR-1000TM Project - Licensing Opportunities and Challenges

International Nuclear Information System (INIS)

Popov, N.; Doerffer, S.; Ion, R.; Hopwood, J.

2011-01-01

Atomic Energy of Canada Limited (AECL) has developed the Advanced CANDU Reactor TM 1 1000 (ACR-1000 TM ) as an evolutionary advancement of the current CANDU 6 reactor. The ACR-1000 design has evolved from AECL's in-depth knowledge of CANDU TM systems, components, and materials, as well as the experience and feedback received from owners and operators of CANDU plants. The ACR design retains the proven strengths and features of CANDU reactors, while incorporating innovations and state-of-the-art technology. It also features major improvements in economics, inherent safety characteristics, and performance, while retaining the proven benefits of the CANDU family of nuclear power plants. To ensure that the ACR design is compliant with Canadian and international requirements, regulatory pre-project reviews of the ACR-1000 (and ACR-700 TM 1 with lower output) were conducted early in the design work. The regulatory feedback from these pre-project regulatory reviews helped AECL to better understand regulatory expectations in Canada, US and the UK, and to make further advancements and improvements in the ACR design to meet the Canadian and international regulatory requirements. This paper provides an overview of the key design features of the ACR-1000 reactor design, and summary of the pre-project reviews by those above-mentioned regulatory bodies, demonstrating opportunities and challenges in licensing process of and pointing to the importance of efficient vendor-regulator interaction. (author)

7 CFR 1412.21 - Election of base acres.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Election of base acres. 1412.21 Section 1412.21... CROP REVENUE ELECTION PROGRAM FOR THE 2008 AND SUBSEQUENT CROP YEARS Establishment of Base Acres for a Farm for Covered Commodities § 1412.21 Election of base acres. (a) Subject to adjustments in paragraph...

Closure Strategy Nevada Test Site Area 5 Radioactive Waste Management Site

Energy Technology Data Exchange (ETDEWEB)

NSTec Environmental Management

2007-03-01

This paper presents an overview of the strategy for closure of part of the Area 5 Radioactive Waste Management Site (RWMS) at the Nevada Test Site (NTS), which is about 65 miles northwest of Las Vegas, Nevada (Figure 1). The Area 5 RWMS is in the northern part of Frenchman Flat, approximately 14 miles north of Mercury. The Area 5 RWMS encompasses 732 acres subdivided into quadrants, and is bounded by a 1,000-foot (ft)-wide buffer zone. The northwest and southwest quadrants have not been developed. The northeast and southeast quadrants have been used for disposal of unclassified low-level radioactive waste (LLW) and indefinite storage of classified materials. This paper focuses on closure of the 38 waste disposal and classified material storage units within the southeast quadrant of the Area 5 RWMS, called the ''92-Acre Area''. The U.S Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO) is currently planning to close the 92-Acre Area by 2011. Closure planning for this site must take into account the regulatory requirements for a diversity of waste streams, disposal and storage configurations, disposal history, and site conditions. For ease of discussion, the 92-Acre Area has been subdivided into six closure units defined by waste type, location, and similarity in regulatory requirements. Each of the closure units contains one or more waste disposal units; waste disposal units are also called waste disposal cells. The paper provides a brief background of the Area 5 RWMS, identifies key closure issues for the 92-Acre Area, recommends actions to address the issues, and provides the National Security Technologies, LLC (NSTec), schedule for closure.

7 CFR 1412.44 - Notification of base acres.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Notification of base acres. 1412.44 Section 1412.44... through 2012 § 1412.44 Notification of base acres. The operator and owners of record of a farm will be notified in writing of the number of base acres eligible for enrollment in a contract, unless such operator...

Advanced construction methods in ACR

International Nuclear Information System (INIS)

Elgohary, M.; Choy, E.; Yu, S.K.W.

2002-01-01

The ACR - Advanced CANDU Reactor, developed by Atomic Energy of Canada Limited (AECL), is designed with constructability considerations as a major requirement during all project phases from the concept design stage to the detail design stage. This necessitated a much more comprehensive approach in including constructability considerations in the design to ensure that the construction duration is met. For the ACR-700, a project schedule of 48 months has been developed for the nth replicated unit with a 36 month construction period duration from First Concrete to Fuel Load. An overall construction strategy that builds on the success of the construction methods that are proven in the construction of the Qinshan CANDU 6 project has been developed for the ACR. The overall construction strategy comprises the 'Open Top' construction technique using a Very Heavy Lift crane, parallel construction activities, with extensive modularization and prefabrication. In addition, significant applications of up to date construction technology will be implemented, e.g. large volume concrete pours, prefabricated rebar, use of climbing forms, composite structures, prefabricated permanent formwork, automatic welding, and utilization of the latest electronic technology tools such as 3D CADDs modelling yields a very high quality, clash free product to allow construction to be completed 'right the first time' and eliminates rework. Integration of 3D CADDs models and scheduling tools such as Primavera has allowed development of actual construction sequences and an iterative approach to schedule verification and improvement. Modularization and prefabrication are major features of the ACR design in order to achieve the project schedule. For the reactor building approximately 80% of the volume will be installed as modules or prefabricated assembles. This ensures critical path activities are achieved. This paper examines the advanced construction methods implemented in the design in order to

ACR-700 advanced technologies

International Nuclear Information System (INIS)

Tapping, R.L.; Turner, C.W.; Yu, S.K.W.; Olmstead, R.; Speranzini, R.A.

2004-01-01

A successful advanced reactor plant will have optimized economics including reduced operating and maintenance costs, improved performance, and enhanced safety. Incorporating improvements based on advanced technologies ensures cost, safety and operational competitiveness of the ACR-700. These advanced technologies include modern configuration management; construction technologies; operational technology for the control centre and information systems for plant monitoring and analysis. This paper summarizes the advanced technologies used to achieve construction and operational improvements to enhance plant economic competitiveness, advances in the operational technology used for reactor control, and presents the development of the Smart CANDU suite of tools and its application to existing operating reactors and to the ACR-700. (author)

Remediation System Evaluation, Douglas Road Landfill Superfund Site

Science.gov (United States)

The Douglas Road Landfill Superfund Site is located in St. Joseph County just north of Mishawaka,Indiana. The site consists of a 16-acre capped landfill located on an approximately 32-acre lot (includingthe land purchased in 1999 for a wetlands...

75 FR 71079 - Site Renumbering Notice; Foreign-Trade Zone 29-Louisville, KY

Science.gov (United States)

2010-11-22

... Interstate 65, Shepherdsville, Bullitt County; Site 7 (191 acres)--Henderson County Riverport Authority... Park, 376 Zappos Blvd., Shepherdsville, Bullitt County [formerly part of Site 6]; and, Site 13 (6 acres...

7 CFR 1412.23 - Base acres and Conservation Reserve Program.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Base acres and Conservation Reserve Program. 1412.23... Base Acres for a Farm for Covered Commodities § 1412.23 Base acres and Conservation Reserve Program. (a... year, adjust the base acres for covered commodities and peanuts with respect to the farm by the number...

ACRE: Absolute concentration robustness exploration in module-based combinatorial networks

KAUST Repository

Kuwahara, Hiroyuki; Umarov, Ramzan; Almasri, Islam; Gao, Xin

2017-01-01

To engineer cells for industrial-scale application, a deep understanding of how to design molecular control mechanisms to tightly maintain functional stability under various fluctuations is crucial. Absolute concentration robustness (ACR) is a category of robustness in reaction network models in which the steady-state concentration of a molecular species is guaranteed to be invariant even with perturbations in the other molecular species in the network. Here, we introduce a software tool, absolute concentration robustness explorer (ACRE), which efficiently explores combinatorial biochemical networks for the ACR property. ACRE has a user-friendly interface, and it can facilitate efficient analysis of key structural features that guarantee the presence and the absence of the ACR property from combinatorial networks. Such analysis is expected to be useful in synthetic biology as it can increase our understanding of how to design molecular mechanisms to tightly control the concentration of molecular species. ACRE is freely available at https://github.com/ramzan1990/ACRE.

ACRE: Absolute concentration robustness exploration in module-based combinatorial networks

KAUST Repository

Kuwahara, Hiroyuki

2017-03-01

To engineer cells for industrial-scale application, a deep understanding of how to design molecular control mechanisms to tightly maintain functional stability under various fluctuations is crucial. Absolute concentration robustness (ACR) is a category of robustness in reaction network models in which the steady-state concentration of a molecular species is guaranteed to be invariant even with perturbations in the other molecular species in the network. Here, we introduce a software tool, absolute concentration robustness explorer (ACRE), which efficiently explores combinatorial biochemical networks for the ACR property. ACRE has a user-friendly interface, and it can facilitate efficient analysis of key structural features that guarantee the presence and the absence of the ACR property from combinatorial networks. Such analysis is expected to be useful in synthetic biology as it can increase our understanding of how to design molecular mechanisms to tightly control the concentration of molecular species. ACRE is freely available at https://github.com/ramzan1990/ACRE.

75 FR 51752 - Foreign-Trade Zone 72-Indianapolis, IN; Application for Reorganization Under Alternative Site...

Science.gov (United States)

2010-08-23

... within a grantee's ``service area'' in the context of the Board's standard 2,000-acre activation limit... the following sites: Site 1: (4,832 acres) within the Indianapolis International Airport complex; Site... acres) within the Park 100 Business Park, located at 71st Street and Interstate 465, Indianapolis...

ACRES At-Risk Task Force: Dropout Survey.

Science.gov (United States)

Bull, Kay S.; And Others

This paper describes a study by the American Council on Rural Special Education (ACRES) to determine its membership's opinions on priorities and expertise regarding the dropout problem. ACRES members, primarily rural special-education teachers, parents, and collateral service workers, were surveyed about the dropout problem and what research they…

The Automated Conflict Resolution System (ACRS)

Science.gov (United States)

Kaplan, Ted; Musliner, Andrew; Wampler, David

1993-01-01

The Automated Conflict Resolution System (ACRS) is a mission-current scheduling aid that predicts periods of mutual interference when two or more orbiting spacecraft are scheduled to communicate with the same Tracking and Data Relay Satellite (TDRS) at the same time. The mutual interference predicted has the potential to degrade or prevent communications. Thus the ACRS system is a useful tool for aiding in the scheduling of Space Network (SN) communications.

78 FR 59914 - Foreign-Trade Zone 160-Anchorage, Alaska; Application for Reorganization Under Alternative Site...

Science.gov (United States)

2013-09-30

...: Site 1 (56.89 acres)--the Port of Anchorage and Port of Anchorage Industrial Park, 1075 Dock Rd., 1076... acres)--619 East Ship Creek Ave., Anchorage; Site 6 (12.2 acres)-- Douglas Management Company, 660...

Crucial role of Asp408 in the proton translocation pathway of multidrug transporter AcrB: evidence from site-directed mutagenesis and carbodiimide labeling.

Science.gov (United States)

Seeger, Markus A; von Ballmoos, Christoph; Verrey, François; Pos, Klaas M

2009-06-30

The three-component AcrA/AcrB/TolC efflux system of Escherichia coli catalyzes the proton motive force-driven extrusion of a variety of cytotoxic compounds. The inner membrane pump component AcrB belongs to the resistance nodulation and cell division (RND) superfamily and is responsible for drug specificity and energy transduction of the entire tripartite efflux system. Systematic mutational analysis of titratable and polar membrane-located amino acids revealed four residues, D407, D408, K940, and, R971, to be of prime importance for AcrB function. Using matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry, D408 was shown to specifically react with dicyclohexylcarbodiimide (DCCD) in a pH-dependent manner. The apparent pK(a) of D408 of 7.4 would enable binding and release of protons under physiological conditions. In contrast to other secondary transporters, D408 was not protected from carbodiimide modification in the presence of drugs, which supports the notion of spatially separated transport pathways for drugs and protons. This study provides evidence for a substantial role of membrane-located carboxylates as a central element of the proton translocation pathway in AcrB and other members of the RND superfamily.

Comparison of Urine Albumin-to-Creatinine Ratio (ACR) Between ACR Strip Test and Quantitative Test in Prediabetes and Diabetes

Science.gov (United States)

Cho, Seon; Kim, Suyoung; Cho, Han-Ik

2017-01-01

Background Albuminuria is generally known as a sensitive marker of renal and cardiovascular dysfunction. It can be used to help predict the occurrence of nephropathy and cardiovascular disorders in diabetes. Individuals with prediabetes have a tendency to develop macrovascular and microvascular pathology, resulting in an increased risk of retinopathy, cardiovascular diseases, and chronic renal diseases. We evaluated the clinical value of a strip test for measuring the urinary albumin-to-creatinine ratio (ACR) in prediabetes and diabetes. Methods Spot urine samples were obtained from 226 prediabetic and 275 diabetic subjects during regular health checkups. Urinary ACR was measured by using strip and laboratory quantitative tests. Results The positive rates of albuminuria measured by using the ACR strip test were 15.5% (microalbuminuria, 14.6%; macroalbuminuria, 0.9%) and 30.5% (microalbuminuria, 25.1%; macroalbuminuria, 5.5%) in prediabetes and diabetes, respectively. In the prediabetic population, the sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy of the ACR strip method were 92.0%, 94.0%, 65.7%, 99.0%, and 93.8%, respectively; the corresponding values in the diabetic population were 80.0%, 91.6%, 81.0%, 91.1%, and 88.0%, respectively. The median [interquartile range] ACR values in the strip tests for measurement ranges of 300 mg/g were 9.4 [6.3-15.4], 46.9 [26.5-87.7], and 368.8 [296.2-575.2] mg/g, respectively, using the laboratory method. Conclusions The ACR strip test showed high sensitivity, specificity, and negative predictive value, suggesting that the test can be used to screen for albuminuria in cases of prediabetes and diabetes. PMID:27834062

Unfolding study of a trimeric membrane protein AcrB.

Science.gov (United States)

Ye, Cui; Wang, Zhaoshuai; Lu, Wei; Wei, Yinan

2014-07-01

The folding of a multi-domain trimeric α-helical membrane protein, Escherichia coli inner membrane protein AcrB, was investigated. AcrB contains both a transmembrane domain and a large periplasmic domain. Protein unfolding in sodium dodecyl sulfate (SDS) and urea was monitored using the intrinsic fluorescence and circular dichroism spectroscopy. The SDS denaturation curve displayed a sigmoidal profile, which could be fitted with a two-state unfolding model. To investigate the unfolding of separate domains, a triple mutant was created, in which all three Trp residues in the transmembrane domain were replaced with Phe. The SDS unfolding profile of the mutant was comparable to that of the wild type AcrB, suggesting that the observed signal change was largely originated from the unfolding of the soluble domain. Strengthening of trimer association through the introduction of an inter-subunit disulfide bond had little effect on the unfolding profile, suggesting that trimer dissociation was not the rate-limiting step in unfolding monitored by fluorescence emission. Under our experimental condition, AcrB unfolding was not reversible. Furthermore, we experimented with the refolding of a monomeric mutant, AcrBΔloop , from the SDS unfolded state. The CD spectrum of the refolded AcrBΔloop superimposed well onto the spectra of the original folded protein, while the fluorescence spectrum was not fully recovered. In summary, our results suggested that the unfolding of the trimeric AcrB started with a local structural rearrangement. While the refolding of secondary structure in individual monomers could be achieved, the re-association of the trimer might be the limiting factor to obtain folded wild-type AcrB. © 2014 The Protein Society.

Characterization and enzymatic properties of protein kinase ACR4 from Arabidopsis thaliana.

Science.gov (United States)

Zhao, Yu; Liu, Xuehe; Xu, Ziyan; Yang, Hui; Li, Jixi

2017-07-22

Serine/threonine-protein kinase-like protein ARABIDOPSIS CRINKLY4 (ACR4), a transmembrane protein of Arabidopsis thaliana, plays important roles in cell division and differentiation. Although accumulating studies shed light on the function of ACR4, the structure and catalytic mechanism of ACR4 remain to be elucidated. Here, we report the purification and enzymatic properties of the intracellular kinase domain (residues 464-799) of ACR4 (ACR4 IKD ). Through Ni-affinity chromatography and gel filter chromatography methods, we successfully obtain high-purity ACR4 IKD protein from Escherichia coli. Dynamic light scattering and gel-filtration methods reveal that ACR4 IKD distributes with high homogeneity and exists as a monomer in solution. In addition, the ACR4 IKD protein has typical kinase activity with myelin basic protein (MBP) as the substrate. Our study may lay the foundation for structure determination of ACR4 IKD and further functional research, for example, screening significant substrates of ACR4 in Arabidopsis thaliana. Copyright © 2017 Elsevier Inc. All rights reserved.

The Prevalence of acrA and acrB Genes Among Multiple-Drug Resistant Uropathogenic Escherichia coli Isolated From Patients With UTI in Milad Hospital, Tehran

Directory of Open Access Journals (Sweden)

Maleki

2016-09-01

Full Text Available Background Urinary tract infection (UTI is one of the most common infectious diseases and nosocomial infections worldwide, and uropathogenic Escherichia coli is the primary cause of UTI. Due to increased antibiotic resistance and the emergence of multidrug resistant (MDR UPEC clones, the treatment of UTI is difficult. The occurrence of MDR in E. coli has been attributed to the AcrAB-TolC complex of efflux pumps. Objectives The aim of this study was to complete a frequency evaluation of acrA and acrB genes among UPEC MDR strains isolated from patients with UTI who were admitted to Milad hospital in Tehran. Methods For 123 UPEC strains that were isolated and diagnosed from the urine samples of patients using biochemical tests, antibiotic susceptibility was carried out using the disc diffusion method according to CLSI guidelines. Isolates that were resistant to at least one antimicrobial agent in three or more of the categories were considered to be MDR. The presence and frequency of acrA and acrB genes was determined using PCR. Results The rates of antibiotic resistance to ampicillin, cefalotin, tetracycline, cefazolin, ceftriaxone, ceftizoxime, ceftazidime, ciprofloxacin, and cotrimoxazole were 82.9%, 78.1%, 61.1%, 49.5%, 38.2%, 30.2%, 26.1%, 42.2%, and 60.1%, respectively. The isolates were most sensitive to nitrofurantoin (95.9%, gentamicin (77.2%, and amikacin (71.5%. A total of 78% of the isolates were MDR. The frequency of the acrA gene was 82.90%, the acrB gene was 95.90% and acrA + acrB was 95.90%. There was no significant difference between acrA and acrB frequency relating to bacterial antibiotic resistance. Conclusions Our results showed that ways to control the treatment of UTI for the prevention of MDR occurrence should be sought. For a better study of efflux pumps, a comprehensive and detailed study regarding the presence of efflux pumps gees is required.

Automatic coding method of the ACR Code

International Nuclear Information System (INIS)

Park, Kwi Ae; Ihm, Jong Sool; Ahn, Woo Hyun; Baik, Seung Kook; Choi, Han Yong; Kim, Bong Gi

1993-01-01

The authors developed a computer program for automatic coding of ACR(American College of Radiology) code. The automatic coding of the ACR code is essential for computerization of the data in the department of radiology. This program was written in foxbase language and has been used for automatic coding of diagnosis in the Department of Radiology, Wallace Memorial Baptist since May 1992. The ACR dictionary files consisted of 11 files, one for the organ code and the others for the pathology code. The organ code was obtained by typing organ name or code number itself among the upper and lower level codes of the selected one that were simultaneous displayed on the screen. According to the first number of the selected organ code, the corresponding pathology code file was chosen automatically. By the similar fashion of organ code selection, the proper pathologic dode was obtained. An example of obtained ACR code is '131.3661'. This procedure was reproducible regardless of the number of fields of data. Because this program was written in 'User's Defined Function' from, decoding of the stored ACR code was achieved by this same program and incorporation of this program into program in to another data processing was possible. This program had merits of simple operation, accurate and detail coding, and easy adjustment for another program. Therefore, this program can be used for automation of routine work in the department of radiology

Steam generator design requirements for ACR-1000

International Nuclear Information System (INIS)

Subash, S.; Hau, K.

2006-01-01

Atomic Energy of Canada Limited (AECL) has developed the ACR-1000 (Advanced CANDU Reactor-1000 ) to meet market expectations for enhanced safety of plant operation, high capacity factor, low operating cost, increased operating life, simple component replacement, reduced capital cost, and shorter construction schedule. The ACR-1000 design is based on the use of horizontal fuel channels surrounded by a heavy water moderator, the same feature as in all CANDU reactors. The major innovation in the ACR-1000 is the use of low enriched uranium fuel, and light water as the coolant, which circulates in the fuel channels. This results in a compact reactor core design and a reduction of heavy water inventory, both contributing to a significant decrease in capital cost per MWe produced. The ACR-1000 plant is a two-unit, integrated plant with each unit having a nominal gross output of about 1165 MWe with a net output of approximately 1085 MWe. The plant design is adaptable to a single unit configuration, if required. This paper focuses on the technical considerations that went into developing some of the important design requirements for the steam generators for the ACR-1000 plant and how these requirements are specified in the Technical Specification, which is the governing document for the steam generator (SG) detail design. Layout of these SGs in the plant is briefly described and their impacts on the SG design. (author)

Comparing new diagnostic criteria of 2010 ACR/EULAR with 1987 ACR criteria in rheumatoid arthritis

Directory of Open Access Journals (Sweden)

Fatemeh Shirani

2017-01-01

Full Text Available Background: Rheumatoid Arthritis (RA is a chronic inflammatory disease presenting with inflammation, tenderness and destruction of the synovial joints, resulting in severe disability and early death due to complication of disease. Previous diagnostic criteria are not useful for identifying patients who need early treatment. Thus, new diagnostic criteria for faster diagnosis of disease are introduced in 2010. The aim of this study was to compared 1987 ACR (American College of Rheumatology criteria and 2010 ACR/EULAR (European League Against Rheumatism classification criteria for diagnosis of rheumatoid arthritis. Methods: In this Cohort prospective study, patients with early arthritis were evaluated   according to the old and new diagnostic criteria and followed-up every two monthly for one year (2012-2013 in Hazrat-e Rasool University Hospital, Tehran. Inclusion criteria of this study were age more than 18 year and indefinite diagnosis of arthritis. For all of patients physical examination by expert rheumatologist was done and lab data include erythrocyte sedimentation rate (ESR, C-reactive protein (CRP, anti-cyclic citrullinated peptide (Anti-CCP and rheumatoid factor was requested. The sensitivity, specificity, positive and negative predictive values were then determined for each diagnostic criteria. Results: In this study 104 patients including 28 males (26.9% and 76 females (73.1% with the mean age of 44.2±13.7 years were included. At the end of one year follow-up, 82 were diagnosed to have RA while other 22 patients were not categorized as RA. Sensitivity for ESR, CRP, Anti-CCP and rheumatoid factor in 2010 ACR/EULAR criteria was 52%, 19%, 48%, 28% and specificity for them was 45%, 71%, 27%, 79% respectively. Number of small and large joint arthritis were more in patients with Rheumatoid Arthritis (RA rather than other arthritis (P=0.0001. Sensitivity and specificity for small joints involvement was 87% and 54% and for large joints

Women's Leadership in the ACR, 2001-2015.

Science.gov (United States)

Patel, Amy K; Fielding, Julia; Macura, Katarzyna J; Applegate, Kimberly E; Zackula, Rosalee; Arleo, Elizabeth Kagan

2017-06-01

To assess the trends of women in voluntary leadership roles in the ACR from 2001 to 2015. Retrospective leadership records from 2001 to 2015 were collected from the ACR Membership Database based on member demographics, gender, and participation in leadership roles at the national and state level. Data were sorted by gender and year to assess the proportion of women in each leadership position relative to total member/representation counts. Overall, there were increasing numbers of women represented in ACR leadership. From 2001 to 2015, there were increasing rates of women achieving fellowship in the College (7%-11%), now at parity with male member rates. Representation by women has risen from 7% to 21% for state chapter presidents and from 14% to 18% for state councilors. Comparing rolling 5-year averages from 2001-2005 and 2011-2015 showed statistically significant increases (P leadership roles. Women members of the council steering committee rose from 13% in 2001 to 19% in 2015, peaking at 24% in 2014. The Board of Chancellors (BOC) showed the largest increase in women, from 9% to 33%, with a peak at 37% in 2014. However, no BOC chairs were women, one council speaker was a woman, two women were ACR presidents, and two women were vice presidents. Women's participation in ACR leadership has increased significantly at the state level and in fellowship recognition. Although there are increasing numbers of women on the BOC, top positions remain male-dominated at the national level. Published by Elsevier Inc.

ACR: Licensing and design readiness

International Nuclear Information System (INIS)

Alizadeh, A.

2009-01-01

Full text The Canadian nuclear technology has a long history dating back to the 1940s. In this regard, Canada is in a unique situation, shared only by a very few countries, where original nuclear power technology has been invented and further developed. Canadian Nuclear Safety Commission (CNSC), then called AECB, was established in 1946. CNSC focuses on nuclear security, nuclear safety, establishing health and safety regulations, and has also played an instrumental role in the formation of the IAEA. CNSC has provided assistance to the establishment of regulatory authorities in AECL's client countries such as Korea, Argentina, China and Romania. AECL has developed the Gen III+ ACR 1000 as evolutionary advancement of the current CANDU 6 reactor. ACR-1000 has evolved from AECL's in depth experience with CANDU systems, components, and materials, as well as the feedback received from owners and operators of CANDU plants. The ACR-1000 design retains the proven strengths and features of CANDU reactors, while incorporating innovations and state-of-the-art technology. It also features major improvements in economics, inherent safety characteristics, and performance. ACR-1000 has completed its Basic Engineering, has advanced in the licensing process in Canada, and is ready for deployment in Canadian and world markets. EC6 is an evolution of CANDU 6 and is a Gen III natural uranium fuelled reactor. Its medium size and potential for fuel localization and advanced fuel cycles is an optimal strategic solution in many markets.AECL's reactor products are shown to be compliant with a variety of licensing and regulatory requirements. These include the new CNSC DRD-337, IAEA NS-R1, and EUR. This allows the countries interested in CANDU reactor products to be confident of its licensing in their own regulatory regimes.

76 FR 73587 - Foreign-Trade Zone 183-Austin, Tx; Site Renumbering Notice

Science.gov (United States)

2011-11-29

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Foreign-Trade Zone 183--Austin, Tx; Site... (Board Order 1366). FTZ 183 currently consists of 8 ``sites'' totaling some 2,818 acres in the Austin... Austin Enterprise Zone, located at Bolm Road and Gardner Road, Austin; Site 2 (50 acres)--Balcones...

75 FR 17692 - Foreign-Trade Zone 75 -- Phoenix, Arizona, Application for Reorganization under Alternative Site...

Science.gov (United States)

2010-04-07

...'' in the context of the Board's standard 2,000-acre activation limit for a general-purpose zone project... terminal at the Phoenix Sky Harbor International Airport, Phoenix; Site 2 (18 acres) CC&F South Valley..., 4747 West Buckeye Road, Phoenix; Site 4 (18 acres) - Santa Fe Business Park, 47th Avenue and Campbell...

Constructability - from Qinshan to the ACR

International Nuclear Information System (INIS)

Elgohary, M.; Fairclough, N.; Ricciuti, R.

2003-01-01

AECL has recognised the importance of Constructability for many years and is applying its principals to CANDU projects with increasing success. Constructability is defined as the consideration of construction knowledge and experience during all phases of a project, and recognizes that maximum benefit can be achieved during the concept phases of a project. The CANDU 6 Nuclear Power Plant has been constructed eleven times in the last 25 years, however, the last two units being completed on the Qinshan project in China have employed some very innovative construction methods that have not been used on the previous units. In order to make nuclear power generation more competitive, shorter construction schedules and reduced project costs and risks are essential objectives. The application of constructability principles is a major contributor to achieving these objectives. The success of Qinshan has increased the confidence in the new construction methods which are being implemented on the ACR (Advanced CANDU Reactor) successfully. An ACR construction strategy that utilizes advanced construction techniques has been developed by AECL. The strategy includes paralleling of activities by using extensive modularization and the vertical installation of equipment and modules into the reactor building, using a VHL (Very Heavy Lift) crane. This strategy allows short schedules to be met with a minimum risk to the project. This paper describes the latest construction methods used successfully on the Qinshan CANDU 6 project and looks at the extensive implementation of similar methods for ACR. It is concluded, based on the Qinshan success, that the ACR construction schedule is readily achievable. (author)

Structural and functional aspects of the multidrug efflux pump AcrB.

Science.gov (United States)

Eicher, Thomas; Brandstätter, Lorenz; Pos, Klaas M

2009-08-01

The tripartite efflux system AcrA/AcrB/TolC is the main pump in Escherichia coli for the efflux of multiple antibiotics, dyes, bile salts and detergents. The inner membrane component AcrB is central to substrate recognition and energy transduction and acts as a proton/drug antiporter. Recent structural studies show that homotrimeric AcrB can adopt different monomer conformations representing consecutive states in an allosteric functional rotation transport cycle. The conformational changes create an alternate access drug transport tunnel including a hydrophobic substrate binding pocket in one of the cycle intermediates.

Funding a California Superfund site with minimal state or federal money

International Nuclear Information System (INIS)

Mullaney, M.; Lemcke, H.

1996-01-01

The remediation of abandoned waste sites is a difficult task with limited funding from local, state and federal governments. It has become necessary for site managers and property owners to locate novel sources of funding and services to remediate these sites. An example of such a site is Pacific States Steel Corporation (PSSC) in Union City, California. PSSC abruptly closed its doors in 1978. The former employees (pensioners) of PSSC, won a civil suit in Federal Court for reinstatement of their medical benefits. The Federal Court took control of PSSC's largest remaining asset: a 93 acre site which was covered with slag, dilapidated buildings, a petroleum contaminated cooling pond, asbestos, PCBs, 800 barrels containing unknown fluids, heavy metals, non hazardous solid waste, and other wastes. A court-appointed Special Master submitted to the Court a plan to clean up and develop the 93 acre site to its highest and best use in order to pay the pensioners and other creditors. Total cleanup costs were estimated at over $30 million. Currently, approximately 31 acres are ready for development and 62 acres have all but two structures removed. All above ground waste streams have been remediated or contained

Energy-conserving site-design case study, Radisson, New York. Final report

Energy Technology Data Exchange (ETDEWEB)

1979-12-01

Radisson is a 2,950-acre new community currently being developed by the New York State Urban Development Corporation and located in central New York, 12 miles north-west of Syracuse. Case-study sites selected for this project are a 95-acre residential site and the 51-acre Town Center of the new community. Development on the Residential Site is a low-density (2.8 dwelling units/acre) mixture of single-family, townhouse and multi-family units. Development on the Town Center site is a mixture of small-scale commercial use (144,000 sq. ft.) and 330+ multi-family dwelling units. Energy-conserving plans developed for both sites have focused on passive measures to reduce energy use for space heating. Utility-system options have been identified for both sites, but require further study as to feasibility and cost. This report summarizes energy savings and cost differentials due to passive measures incorporated in both the residential and Town Center Plans. The future implementation schedule, also discussed, summarizes the procedures an schedule required for implementation of the passive measures, as well as further study required for the development of utility-system options. 4 tables.

Site Rehabilitation Completion Report with No Further Action Proposal for the Northeast Site

Energy Technology Data Exchange (ETDEWEB)

Daniel, Joe [Stoller Newport News Technology, Inc., Grand Junction, CO (United States); Tabor, Charles [Stoller Newport News Technology, Inc., Grand Junction, CO (United States); Survochak, Scott [U.S. Department of Energy, Office of Legacy Management, Grand Junction, CO (United States)

2013-05-01

The purpose of this Site Rehabilitation Completion Report is to present the post-active-remediation monitoring results for the Northeast Site and to propose No Further Action with Controls. This document includes information required by Chapter 62-780.750(4)(d), 62-780.750(6), and 62-780.600(8)(a)27 Florida Administrative Code (F.A.C.). The Closure Monitoring Plan for the Northeast Site and 4.5 Acre Site (DOE 2009a) describes the approach for post-active-remediation monitoring. The Young - Rainey Science, Technology, and Research Center (STAR Center) is a former U.S. Department of Energy (DOE) facility constructed in the mid-1950s. The 99-acre STAR Center is located in Largo, Florida. The Northeast Site is located in the northeast corner of the STAR Center. The Northeast Site meets all the requirements for an RMO II closure—No Further Action with Controls. DOE is nearing completion of a restrictive covenant for the Northeast Site. DOE has completed post-active-remediation monitoring at the Northeast Site as of September 2012. No additional monitoring will be conducted.

77 FR 74457 - Foreign-Trade Zone 75-Phoenix, Arizona Application for Expansion (New Magnet Site) Under...

Science.gov (United States)

2012-12-14

..., Arizona Application for Expansion (New Magnet Site) Under Alternative Site Framework An application has...) adopted by the Board (15 CFR 400.2(c)) to include a new magnet site in Phoenix, Arizona. The application... zone project includes the following magnet sites: Site 1 (338 acres)--within the 550-acre Phoenix Sky...

76 FR 14901 - Foreign-Trade Zone 47-Boone County, KY; Application for Reorganization Under Alternative Site...

Science.gov (United States)

2011-03-18

...'' FTZ sites for operators/users located within a grantee's ``service area'' in the context of the Board... current zone project includes the following sites: Site 1 (22 acres)--Northern Kentucky Business Center, 1670 Dolwick Drive, Erlanger, Boone County; and, Site 2 (185 acres)--Park West International Industrial...

Licensing the ACR-700 in the USA

International Nuclear Information System (INIS)

Langman, V.; Ion, R.; Reid, C.; Snell, V.

2003-01-01

Atomic Energy of Canada Ltd. (AECL), via its 100% owned US subsidiary AECL Technologies Inc., is performing a pre-application review of the Advanced CANDU Reactor (ACR) with the US Nuclear Regulatory Commission (USNRC). Completion of this pre-application review by mid-2004, is in support of an application to the USNRC for Standard Design Certification that is targeted for the fall of 2004. The intent of the pre-application review is to deal up-front with potential issues associated with the CANDU reactor genealogy of the ACR that are different from the Light Water Reactor (LWR) and Boiling Water Reactor (BWR) regulatory framework in the USA. The focus of the paper will be to describe the pre-application review process currently underway with the NRC staff. In the context of the pre-application review this paper will provide an overview of the licensing approach being used to introduce the ACR-700 to the USA. (author)

Licensing the ACR-700 in the USA

Energy Technology Data Exchange (ETDEWEB)

Langman, V.; Ion, R. [Atomic Energy of Canada Limited, Mississauga, Ontario (Canada); Reid, C. [Bechtel Power Corporation, San Fransisco, California (United States); Snell, V. [Atomic Energy of Canada Limited, Mississauga, Ontario (Canada)

2003-07-01

Atomic Energy of Canada Ltd. (AECL), via its 100% owned US subsidiary AECL Technologies Inc., is performing a pre-application review of the Advanced CANDU Reactor (ACR) with the US Nuclear Regulatory Commission (USNRC). Completion of this pre-application review by mid-2004, is in support of an application to the USNRC for Standard Design Certification that is targeted for the fall of 2004. The intent of the pre-application review is to deal up-front with potential issues associated with the CANDU reactor genealogy of the ACR that are different from the Light Water Reactor (LWR) and Boiling Water Reactor (BWR) regulatory framework in the USA. The focus of the paper will be to describe the pre-application review process currently underway with the NRC staff. In the context of the pre-application review this paper will provide an overview of the licensing approach being used to introduce the ACR-700 to the USA. (author)

Remedial Action Plan and site design for stabilization of the inactive uranium mill tailings site at Gunnison, Colorado: Remedial action selection report

International Nuclear Information System (INIS)

1992-10-01

The Gunnison uranium mill tailings site is just south of the city limits of Gunnison, Colorado, in the south-central part of the state. The entire site covers 61 acres in the valley of the Gunnison River and Tomichi Creek. Contaminated materials at the Gunnison processing site include the tailings pile, covering about 35 acres to an average depth of nine feet and containing 459,000 cubic yards. Ore storage areas and the former mill processing area cover about 20 acres on the south side of the site. The volume of contaminated materials to be disposed of as part of the remedial action is estimated to be 718,900 cubic yards. An interim action was approved by the US Department of Energy to eliminate existing safety hazards to the Gunnison community. These actions, started in September 1991, included demolition of mill buildings and related processing facilities, excavation of two underground storage tanks, removal of asbestos and other hazardous materials from buildings, storage of those materials in a secured area on the site, and improvements of site security

77 FR 8806 - Foreign-Trade Zone 183-Austin, TX; Application for Reorganization Under the Alternative Site...

Science.gov (United States)

2012-02-15

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [Docket 8-2012] Foreign-Trade Zone 183--Austin... following sites: Site 1 (33 acres)--Interchange within the Austin Enterprise Zone, located at Bolm Road and Gardner Road, Austin; Site 2 (50 acres)--Balcones Research site located in north central Austin at the...

MO-AB-207-00: ACR Update in MR, CT, Nuclear Medicine, and Mammography

International Nuclear Information System (INIS)

2015-01-01

A goal of an imaging accreditation program is to ensure adequate image quality, verify appropriate staff qualifications, and to assure patient and personnel safety. Currently, more than 35,000 facilities in 10 modalities have been accredited by the American College of Radiology (ACR), making the ACR program one of the most prolific accreditation options in the U.S. In addition, ACR is one of the accepted accreditations required by some state laws, CMS/MIPPA insurance and others. Familiarity with the ACR accreditation process is therefore essential to clinical diagnostic medical physicists. Maintaining sufficient knowledge of the ACR program must include keeping up-to-date as the various modality requirements are refined to better serve the goals of the program and to accommodate newer technologies and practices. This session consists of presentations from authorities in four ACR accreditation modality programs, including magnetic resonance imaging, computed tomography, nuclear medicine, and mammography. Each speaker will discuss the general components of the modality program and address any recent changes to the requirements. Learning Objectives: To understand the requirements of the ACR MR Accreditation program. The discussion will include accreditation of whole-body general purpose magnets, dedicated extremity systems well as breast MRI accreditation. Anticipated updates to the ACR MRI Quality Control Manual will also be reviewed. To understand the requirements of the ACR CT accreditation program, including updates to the QC manual as well as updates through the FAQ process. To understand the requirements of the ACR nuclear medicine accreditation program, and the role of the physicist in annual equipment surveys and the set up and supervision of the routine QC program. To understand the current ACR MAP Accreditation requirement and present the concepts and structure of the forthcoming ACR Digital Mammography QC Manual and Program

MO-AB-207-00: ACR Update in MR, CT, Nuclear Medicine, and Mammography

Energy Technology Data Exchange (ETDEWEB)

NONE

2015-06-15

A goal of an imaging accreditation program is to ensure adequate image quality, verify appropriate staff qualifications, and to assure patient and personnel safety. Currently, more than 35,000 facilities in 10 modalities have been accredited by the American College of Radiology (ACR), making the ACR program one of the most prolific accreditation options in the U.S. In addition, ACR is one of the accepted accreditations required by some state laws, CMS/MIPPA insurance and others. Familiarity with the ACR accreditation process is therefore essential to clinical diagnostic medical physicists. Maintaining sufficient knowledge of the ACR program must include keeping up-to-date as the various modality requirements are refined to better serve the goals of the program and to accommodate newer technologies and practices. This session consists of presentations from authorities in four ACR accreditation modality programs, including magnetic resonance imaging, computed tomography, nuclear medicine, and mammography. Each speaker will discuss the general components of the modality program and address any recent changes to the requirements. Learning Objectives: To understand the requirements of the ACR MR Accreditation program. The discussion will include accreditation of whole-body general purpose magnets, dedicated extremity systems well as breast MRI accreditation. Anticipated updates to the ACR MRI Quality Control Manual will also be reviewed. To understand the requirements of the ACR CT accreditation program, including updates to the QC manual as well as updates through the FAQ process. To understand the requirements of the ACR nuclear medicine accreditation program, and the role of the physicist in annual equipment surveys and the set up and supervision of the routine QC program. To understand the current ACR MAP Accreditation requirement and present the concepts and structure of the forthcoming ACR Digital Mammography QC Manual and Program.

76 FR 60938 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Power...

Science.gov (United States)

2011-09-30

... Subcommittee on Power Uprates; Notice of Meeting The ACRS Subcommittee on Power Uprates will hold a meeting on...) associated with the Nine Mile Point extended power uprate application. The [[Page 60939

Collapse and erosion at the low-level radioactive-waste burial site near Sheffield, Illinois

International Nuclear Information System (INIS)

Gray, J.R.; McGovern, L.L.

1986-01-01

Collapse and erosion are the dominant landform-modification processes at the Sheffield, Illinois, low-level radioactive-waste burial site. Records on collapse have been collected by the site contractor since 1978 and include data of inspection, location, and cavity dimensions. Fluvial sediment yield was measured by the US Geological Survey beginning in July 1982 from three gaged areas which drained two-thirds of the 20-acre site, and from a gaged 3.5-acre area in undisturbed terrain 0.3 mile south of the site. A total of 302 collapse cavities were recorded from October 1978 through September 1985. Based on the weight of earth material equivalent to cavity volume, an annual average of 6 tons of sediment per acre of site area has moved downward due to collapse. Sixty-two percent of the collapses occurred in swales between waste-disposal trenches or near trench boundaries, while the remainder occurred in earth material covers over trench interiors. Two-thirds of the collapses occurred during the months of February, March, and April. On-site fluvial sediment yield averaged 2 tons per acre per year from July 1982 through July 1984. Although this yield was approximately 200 times that from the undisturbed area, it is about one-half the annual sediment yield expected from a 20-acre row-crop agricultural basin on an 8% slope near Sheffield

Nuclear fission - the unexpected discovery seventy years ago

International Nuclear Information System (INIS)

Weis, Michael

2008-01-01

Seventy years ago, on December 17, 1938, Otto Hahn, Lise Meitner, and Fritz Strassmann discovered nuclear fission. It was a serendipitous discovery resulting from the consistent pursuit, for many years, of occasionally unexpected radiochemical experimental findings. Hardly any other scientific discovery has had such direct bearing on our life, changing our view of the world. It over-threw the tenet of physics, believed to be incontestable, that the atom was indivisible. The use of nuclear power it has made possible has given rise to immense benefits, but it has also allowed mankind's most dreadful weapon so far to be developed. All this is ample reason seventy years later to recall the discovery, the discoverers and their times. It will also be shown what later generations have made of this discovery, and what economic and ecological prospects it continues to hold. (orig.)

A relação médico-paciente em Rio Branco/AC sob a ótica dos pacientes Patient - physician relationship in Acre, Rio Branco, from the patient's point of view

Directory of Open Access Journals (Sweden)

Maria das Graças Alves Pereira

2005-06-01

Full Text Available OBJETIVO: Avaliar, em uma Unidade de Saúde de Rio Branco, o nível de satisfação dos pacientes com a relação médico-paciente (RMP praticada. MÉTHODS: Estudo descritivo-analítico. Foram entrevistados 50 pacientes egressos de internação recente na Fundação Hospital Estadual do Acre (FUNDHACRE, com idades entre 18 e 50 anos. Foram excluídos pacientes em diálise ou UTI, com estado de consciência alterado, portadores de deficiência mental, impossibilitados de comunicação verbal e que não concordaram em participar. O teste de Qui-quadrado (chi2 foi usado para comparação entre as variáveis categóricas, com grau de significância para pBACKGROUND: The main objective of the present paper is to evaluate the satisfaction levels with the physician-patient relationship (PPR practiced at a health care unit of Rio Branco, Acre, Brazil. Interviews were carried out right after patients' dismissal from the "Fundação Hospital Estadual do Acre". METHODS: Descriptive and analytical analyses were performed. Fifty patients 18 to 50 years of age were studied. Semi-structured questionnaires were used. Patients with altered states of consciousness, mental deficiency or verbal communication impairment and those who were not willing to participate in the research were excluded. Descriptive data were appraised for SPSS®. RESULTS: Sixty-four percent of the patients (32/50 believe that the physician- patient relationship interferes with patients' improvement; Seventy percent (35/50 evaluated their physician-patient relationship as satisfactory and seventy two percent (36/50 considered positive, the attention received from physicians. Albeit results are in accordance with the cultural expectations, further research on this subject is recommended. CONCLUSIONS: the satisfaction with PPR, showed association with the variables related to the personal form of communication practiced between physicians and patients.

75 FR 4882 - Meeting of the ACRS Subcommittee on EPR; Notice of Meeting

Science.gov (United States)

2010-01-29

... NUCLEAR REGULATORY COMMISSION Advisory Committee On Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on EPR; Notice of Meeting The ACRS U.S. Evolutionary Power Reactor (EPR) Subcommittee will hold a... with Open Items concerning the U.S. EPR Design Certification (DCD) Application and the Calvert Cliffs...

Seventy Years of the EPR Paradox

OpenAIRE

Kupczynski, Marian

2007-01-01

In spite of the fact that statistical predictions of quantum theory (QT) can only be tested if large amount of data is available a claim has been made that QT provides the most complete description of an individual physical system. Einstein's opposition to this claim and the paradox he presented in the article written together with Podolsky and Rosen in 1935 inspired generations of physicists in their quest for better understanding of QT. Seventy years after EPR article it is clear that witho...

DCS emulator development for the ACR-1000 simulator

International Nuclear Information System (INIS)

Nakashima, Y.; Trueman, R.; Ishii, K.

2010-01-01

Nuclear Power Plant (NPP) simulators are the main means for operator training and as such are a crucial part of the NPP operation life-cycle. Hitachi, Ltd., Information and Control Systems Company (henceforth 'Hitachi') is the preferred DCS and DCS emulator developer and supplier for the ACR-1000 NPP control system. Hitachi's concept for the DCS (distributed control system) portion of the ACR-1000 simulator is 'total emulation of the DCS' by software. This paper will review the current status of the technical development and the major project milestones. (author)

Burnup dependence of coolant void reactivity for ACR-1000 cell

International Nuclear Information System (INIS)

Le Tellier, R.; Marleau, G.; Hebert, A.; Roubstov, D.; Altiparmakov, D.; Irish, D.

2008-01-01

The Advanced Candu Reactor (ACR-1000) is light water cooled, fueled with enriched uranium and has a smaller lattice pitch than the Candu-6. As a result, the neutronic behavior of the ACR-1000 cell is expected to be somewhat different from that of the Candu-6 leading to a negative coolant void reactivity (CVR). Here we evaluate the CVR for the ACR-1000 cell using the lattice code DRAGON and compare our results with those obtained using the code WIMS-AECL. The differences observed between these two codes for the burnup dependence of the CVR is mainly explained in terms of the specific cell leakage model used by both codes. (authors)

Patient phenotypes in fibromyalgia comorbid with systemic sclerosis or rheumatoid arthritis: influence of diagnostic and screening tests. Screening with the FiRST questionnaire, diagnosis with the ACR 1990 and revised ACR 2010 criteria.

Science.gov (United States)

Perrot, Serge; Peixoto, Mariana; Dieudé, Philippe; Hachulla, Eric; Avouac, Jerome; Ottaviani, Sebastien; Allanore, Yannick

2017-01-01

Fibromyalgia (FM) may occur with rheumatoid arthritis (RA) and systemic sclerosis (SSc), and debate remains about its diagnosis. We aimed to use three FM tools (a screening tool (FiRST), diagnostic criteria (ACR 1990 and revised 2010), to compare FM prevalence between RA and SSc patients, to describe the phenotypes of patients with comorbid FM, and to analyze links between FM and secondary Sjögren's syndrome (SS). Consecutive adult patients with confirmed RA or SSc from four university hospitals were tested with the three FM tools. FiRST detected FM in 22.6% of the 172 RA patients, with confirmation in 22.1% (ACR1990) and 19.1% (ACR2010). ACR1990FM+ RA patients had more diffuse pain, whereas ACR2010FM+ RA patients had higher BMI and pain intensity, more diffuse pain, active disease, disability, and associated SS. FiRST detected FM in 27.8% of the 122 SSc patients, with confirmation in 30.3% (ACR1990) and 23.7% (ACR2010). ACR1990FM+ SSc patients had greater disability and pain intensity, and more diffuse pain, whereas ACR2010FM+ SSc patients had higher BMI, pain intensity, more disability and diffuse pain, and associated SS. Correlations between FM diagnostic and screening tool results were modest in both conditions. Secondary SS was associated with comorbid FM. The prevalence of FM is high in SSc and RA, whatever the FM diagnostic tool used. Secondary SS is associated with FM in both RA and SSc. The revised ACR 2010 FM criteria and FiRST screening tool reveal specific phenotypes potentially useful for improving disease management.

Assessment, Cleanup and Redevelopment Exchange System (ACRES)

Data.gov (United States)

U.S. Environmental Protection Agency — The Assessment, Cleanup and Redevelopment Exchange System (ACRES) is an online database for Brownfields Grantees to electronically submit data directly to EPA.

Usefulness of ACR MRI phantom for quality assurance of MRI instruments

International Nuclear Information System (INIS)

Lee, Jung Whee; Ahn, Kook Jin; Lee, Seung Koo; Na, Dong Gyu; Oh, Chang Hyun; Chang, Yong Min; Lim, Tae Hwan

2006-01-01

To examine whether the ACR phantom could be used in quality standards for magnetic resonance imaging (MRI) instruments in Korea. We conducted the phantom test using the ACR MRI phantom in 20 MRI instruments currently used in Korea. According to ACR criteria, we acquired the phantom images which were then assessed by the following seven tests: geometric accuracy, high spatial resolution, slice thickness accuracy, slice position accuracy, image intensity uniformity, percent signal ghosting, and low contrast object detectability. The phantom images were interpreted by three experienced radiologists according to ACR criteria. Then, we examined the failure rate of each test and evaluated the inter-observer variation in the measurements and test failure. The failure rate of each test could be broken into the following components: geometric accuracy (11-21%), high contrast spatial resolution (10-15%), slice thickness accuracy(6-22%), slice position accuracy (5-17%), image intensity uniformity (6%), percent signal ghosting (16%), and low contrast object detectability (8-10%). In this series, all the failure rates were less than 30%. In addition, no inter-observer variation was seen in the measurements and test failure. ACR MRI phantom promises to be established as the standard phantom for MRI instruments in Korea because of its objectivity in assessing the phantom images

75 FR 49513 - Final Environmental Impact Statement for the Ione Band of Miwok Indians 228.04-Acre Fee-to-Trust...

Science.gov (United States)

2010-08-13

... construct a casino, hotel, parking areas and other facilities. The proposed project is located partially... square-foot hotel and a 30,000 square- foot event/conference center on the 228.04-acre site. The gaming... restaurant, bar, and coffee bar), meeting space, guest support services, offices, and security area. The five...

ACR Appropriateness Criteria on Resectable Rectal Cancer

International Nuclear Information System (INIS)

Suh, W. Warren; Blackstock, A. William; Herman, Joseph; Konski, Andre A.; Mohiuddin, Mohammed; Poggi, Matthew M.; Regine, William F.; Cosman, Bard C.; Saltz, Leonard; Johnstone, Peter A.S.

2008-01-01

The American College of Radiology (ACR) Appropriateness Criteria on Resectable Rectal Cancer was updated by the Expert Panel on Radiation Oncology-Rectal/Anal Cancer, based on a literature review completed in 2007

Validation of the 2010 ACR/EULAR classification criteria for rheumatoid arthritis: slight improvement over the 1987 ACR criteria.

NARCIS (Netherlands)

Britsemmer, K.; Ursum, J.; Gerritsen, M.; Tuyl, L. van; Schaardenburg, D. van

2011-01-01

Abstract: Background Recently, an American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) collaboration developed new classification criteria for rheumatoid arthritis (RA). Objective:To evaluate the diagnostic and discriminative ability of these new criteria compared with

Remedial action plan and site design for stabilization of the inactive uranium mill tailings site at Lakeview, Oregon: Volume 1, Text and appendices A through D

International Nuclear Information System (INIS)

Chernoff, A.R.

1992-07-01

The Lakeview inactive uranium processing site is in Lake County, Oregon, approximately one mile northwest of the town of Lakeview, sixteen miles north of the California-Oregon border, and 96 miles east of Klamath Falls. The total designated site covers an area of 258 acres consisting of a tailings pile (30 acres). seven evaporation ponds (69 acres), the mill buildings, and related structures. The mill buildings and other structures have been decontaminated and are currently being used by Goose Lake Lumber Company. The tailings pile at the processing site was originally stabilized by Atlantic Richfield with an earthen cover 18--24 inches thick. The average depth of the tailings, including the cover, varied from six to eight feet. There were estimated to be 662,000 cubic yards of tailings, windblown contaminated materials, and vicinity property materials. During remedial action under the Uranium Mill Tailings Remedial Action (UMTRA) Project, approximately 264,000 cubic yards of additional contaminated materials were identified from excavations required to remove thorium- and arsenic-contaminated soils. The remedial action for the Lakeview site consisted of the cleanup, relocation, consolidation, and stabilization of all residual radioactive materials and thorium- and arsenic-contaminated materials in a partially below-grade disposal cell at a location approximately seven miles northwest of the tailings site, identified as the Collins Ranch site. A cover, including a radon/infiltration barrier and rock layer for protection from erosion, was Placed on top of the tailings. A rock-soil matrix covers the topslope and provides a growth medium for vegetation. The US Department of Energy (DOE) will retain the license and surveillance and maintenance responsibilities for the final restricted site of 13 acres

Vehicle Technology for Civil Aviation: The Seventies and Beyond

Science.gov (United States)

1972-01-01

The panel discussion on aviation technology for the seventies and beyond is reported. Topics discussed include: Government role in developing and applying new aeronautical technologies, noise and environmental problems, and congestion in the vicinity of major air terminals.

76 FR 7883 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Power...

Science.gov (United States)

2011-02-11

... Subcommittee on Power Uprates; Notice of Meeting The ACRS Subcommittee on Power Uprates will hold a meeting on... will review the staff's evaluation of the Point Beach Units 1 and 2 Extended Power Uprate application... can be made. Thirty five hard copies of each presentation or handout should be provided to the...

Controlled Archaeological Test Site (CATS) Facility

Data.gov (United States)

Federal Laboratory Consortium — CATS facility is at the Construction Engineering Research Laboratory (CERL), Champaign, IL. This 1-acre test site includes a variety of subsurface features carefully...

Validation of MCNP and WIMS-AECL/DRAGON/RFSP for ACR-1000 applications

International Nuclear Information System (INIS)

Bromley, Blair P.; Adams, Fred P.; Zeller, Michael B.; Watts, David G.; Shukhman, Boris V.; Pencer, Jeremy

2008-01-01

This paper gives a summary of the validation of the reactor physics codes WIMS-AECL, DRAGON, RFSP and MCNP5, which are being used in the design, operation, and safety analysis of the ACR-1000 R . The standards and guidelines being followed for code validation of the suite are established in CSA Standard N286.7-99 and ANS Standard ANS-19.3-2005. These codes are being validated for the calculation of key output parameters associated with various reactor physics phenomena of importance during normal operations and postulated accident conditions in an ACR-1000 reactor. Experimental data from a variety of sources are being used for validation. The bulk of the validation data is from critical experiments in the ZED-2 research reactor with ACR-type lattices. To supplement and complement ZED-2 data, qualified and applicable data are being taken from other power and research reactors, such as existing CANDU R units, FUGEN, NRU and SPERT research reactors, and the DCA critical facility. MCNP simulations of the ACR-1000 are also being used for validating WIMS-AECL/ DRAGON/RFSP, which involves extending the validation results for MCNP through the assistance of TSUNAMI analyses. Code validation against commissioning data in the first-build ACR-1000 will be confirmatory. The code validation is establishing the biases and uncertainties in the calculations of the WIMS-AECL/DRAGON/RFSP suite for the evaluation of various key parameters of importance in the reactor physics analysis of the ACR-1000. (authors)

Clinical Image Evaluation of Film Mammograms in Korea: Comparison with the ACR Standard

International Nuclear Information System (INIS)

Gwak, Yeon Joo; Kim, Hye Jung; Kwak, Jin Young; Son, Eun Ju; Ko, Kyung Hee; Lee, Jin Hwa; Lim, Hyo Soon; Lee, You Jin; Park, Ji Won; Shin, Kyung Min; Jang, Yun-Jin

2013-01-01

The goal of this study is to compare the overall quality of film mammograms taken according to the Korean standards with the American College of Radiology (ACR) standard for clinical image evaluation and to identify means of improving mammography quality in Korea. Four hundred and sixty eight sets of film mammograms were evaluated with respect to the Korean and ACR standards for clinical image evaluation. The pass and failure rates of mammograms were compared by medical facility types. Average scores in each category of the two standards were evaluated. Receiver operating characteristic curve analysis was used to identify an optimal Korean standard pass mark by taking the ACR standard as the reference standard. 93.6% (438/468) of mammograms passed the Korean standard, whereas only 80.1% (375/468) passed the ACR standard (p < 0.001). Non-radiologic private clinics had the lowest pass rate (88.1%: Korean standard, 71.8%: ACR standard) and the lowest total score (76.0) by the Korean standard. Average scores of positioning were lowest (19.3/29 by the Korean standard and 3.7/5 by the ACR standard). A cutoff score of 77.0 for the Korean standard was found to correspond to a pass level when the ACR standard was applied. We suggest that tighter regulations, such as, raising the Korean pass mark, subtracting more for severe deficiencies, or considering a very low scores in even a single category as failure, are needed to improve the quality of mammography in Korea

77 FR 4585 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Power Uprates...

Science.gov (United States)

2012-01-30

... Subcommittee on Power Uprates; Notice of Meeting The ACRS Subcommittee on Power Uprates will hold a meeting on... Turkey Point, Units 3 and 4, extended power uprate application. The Subcommittee will hear presentations... possible, so that appropriate arrangements can be made. Thirty-five hard copies of each presentation or...

Technical quality assessment of breast ultrasound according to American College of Radiology (ACR) Standards

International Nuclear Information System (INIS)

Ko, Kyung Hee; Kim, Eun Kyung; Kim, Young Ah; Son, Eun Ju; Oh, Ki Keun; Chung, Sun Yang

2003-01-01

To evaluate the technical quality of breast ultrasound based on American College of Radiology(ACR) standards. Between March 2002 and July 2002, ninety three breast sonograms obtained from 73 institutions were evaluated based on ACR standards for the hardware, technical settings, labeling of the images and identification. Of 93 breast sonograms, a satisfactory compliance with all ACR standards in the performance of breast US examinations was documented in 31% while the remaining 69% did not fully meet all ACR standards. 4.3% of breast US examinations were performed with a convex transducers, and the focal zone was inappropriately positioned in 14.2%. Gray-scale gain was subjectively characterized as inappropriate in 26.9%, and the size of lesion was not measured in 7.5%. Anatomic location of lesions was inappropriately described in 9.3%. The orientation of an US transducer was not properly labeled on any images in 33.3%. Inadequate recording of patient's information was noted in 43.3%. 50% of sonograms at University medical centers and larger general hospitals fully met all ACR standards while 36.8% at radiologic clinics and 12.1% at other private clinics met all ACR standards. Overall, 69% of breast sonograms failed to meet the quality criteria of the ACR standards. Therefore, it is essential to educate the basic technical details in performing breast US for the quality control.

77 FR 28637 - Advisory Committee On Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Power Uprates...

Science.gov (United States)

2012-05-15

... Subcommittee on Power Uprates; Notice of Meeting The ACRS Subcommittee on Power Uprates will hold a meeting on...) associated with the Grand Gulf Nuclear Station Unit 1 extended power uprate application. The Subcommittee... made. Thirty-five hard copies of each presentation or handout should be provided to the DFO thirty...

76 FR 32240 - Advisory Committee on Reactor Safeguards (ACRS) Meeting on the ACRS Subcommittee on Power Uprates

Science.gov (United States)

2011-06-03

... Subcommittee on Power Uprates Notice of Meeting The ACRS Subcommittee on Power Uprates will hold a meeting on... Expanded Operating Domains-Power Distribution Validation and Pin-by-Pin Gamma Scan). The Subcommittee will... hard copies of each presentation or handout should be provided to the DFO thirty minutes before the...

78 FR 70596 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Power Uprates...

Science.gov (United States)

2013-11-26

... Subcommittee on Power Uprates; Notice of Meeting The ACRS Subcommittee on Power Uprates will hold a meeting on... hold discussions with the licensee, (Northern States Power Company of Minnesota), the NRC staff, and... made. Thirty-five hard copies of each presentation or handout should be provided to the DFO thirty...

Coarse-grained Simulations of Substrate Export through Multidrug Efflux Transporter AcrB

Science.gov (United States)

Jewel, Yead; Dutta, Prashanta; Liu, Jin

2017-11-01

The treatment of bacterial infectious diseases hampered by the overexpression of multidrug resistance (MDR) systems. The MDR system actively pumps the antibiotic drugs as well as other toxic compounds out of the cells. During the pumping, AcrB (one of the key MDR components) undergoes a series of large-scale proton/substrate dependent conformational changes. In this work, we implement a hybrid coarse-grained PACE force field that couples the united-atom protein model with the coarse-grained MARTINI water/lipid, to investigate the conformational changes of AcrB. We first develop the substrate force field which is compatible with PACE, then we implement the force field to explore large scale structural changes of AcrB in microsecond simulations. The effects of the substrate and the protonation states of two key residues: Asp407 and Asp408, are investigated. Our results show that the drug export through AcrB is proton as well as substrate dependent. Our simulations explain molecular mechanisms of substrate transport through AcrB complex, as well as provide valuable insights for designing proper antibiotic drugs. Research reported in this publication was supported by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number R01GM122081.

Remediation System Evaluation, Northwest Pipe and Casing Site

Science.gov (United States)

The Northwest Pipe and Casing Site is located in Clackamas, Oregon, approximately 20 miles southeastof Portland. The site consists of approximately 53 acres, and has historically been divided into two parcels(Parcel A to the north and Parcel B to the..

Environmental assessment of remedial action at the Lakeview Uranium Mill Tailings Site, Lakeview, Oregon: Volume 2, Appendices

International Nuclear Information System (INIS)

1985-04-01

This document assesses and compares the environmental impacts of various alternatives for remedial action at the Lakeview uranium mill tailings site located one mile north of Lakeview, Oregon. The site covers 256 acres and contains 30 acres of tailings, 69 acres of evaporation ponds, and 25 acres of windblown materials. Remedial actions must be performed in accordance with standards and with the concurrence of the Nuclear Regulatory Commission. Three alternatives have been addressed in this document. The first alternative (the proposed action) is relocation of all contaminated materials to the Collins Ranch site. The contaminated materials would be consolidated into an embankment constructed partially below grade and covered with radon protection and erosion protection covers. A second alternative would relocate the tailings to the Flynn Ranch site and dispose of the contaminated materials in a slightly below grade embankment. A radon protection and erosion protection cover system would also be installed. The no-action alternative is also assessed. Stabilization in place is not considered due to potential seismic and geothermal hazards associated with the current tailings site, and the inability to meet EPA standards. Volume 2 contains 11 appendices

Development of a platform for interactive training ACRs; Desarrollo de una plataforma interactiva para formacion en ACRs

Energy Technology Data Exchange (ETDEWEB)

Gonzalvo, A.; Martin, J. E.; Herrera, J. A.

2013-07-01

Due to the workload of plant personnel and extension courses, you can use other methods of online learning to complement the methods of classroom learning, so that it minimizes disruption to the day job plant day. GNFE is implementing systems on-line training in ACRs based on MOODLE which has many advantages.

76 FR 44964 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on U.S...

Science.gov (United States)

2011-07-27

... Subcommittee on U.S. Evolutionary Power Reactor; Notice of Meeting The ACRS Subcommittee on U.S. Evolutionary Power Reactor (U.S. EPR) will hold a meeting on August 18, 2011, Room T-2B3, 11545 Rockville Pike... the meeting, if possible, so that appropriate arrangements can be made. Thirty-five hard copies of...

78 FR 8202 - Meeting of the Joint ACRS Subcommittees on Thermal Hydraulic Phenomena and Materials, Metallurgy...

Science.gov (United States)

2013-02-05

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS) Meeting of the Joint ACRS Subcommittees on Thermal Hydraulic Phenomena and Materials, Metallurgy and Reactor Fuels; Notice of Meeting The Joint ACRS Subcommittees on Thermal Hydraulic Phenomena and Materials, Metallurgy and...

Structures of Gate Loop Variants of the AcrB Drug Efflux Pump Bound by Erythromycin Substrate.

Directory of Open Access Journals (Sweden)

Abdessamad Ababou

Full Text Available Gram-negative bacteria such as E. coli use tripartite efflux pumps such as AcrAB-TolC to expel antibiotics and noxious compounds. A key feature of the inner membrane transporter component, AcrB, is a short stretch of residues known as the gate/switch loop that divides the proximal and distal substrate binding pockets. Amino acid substitutions of the gate loop are known to decrease antibiotic resistance conferred by AcrB. Here we present two new AcrB gate loop variants, the first stripped of its bulky side chains, and a second in which the gate loop is removed entirely. By determining the crystal structures of the variant AcrB proteins in the presence and absence of erythromycin and assessing their ability to confer erythromycin tolerance, we demonstrate that the gate loop is important for AcrB export activity but is not required for erythromycin binding.

Portrait of leptospirosis in the State of Acre, Brazil

Directory of Open Access Journals (Sweden)

Eloizy Mariana Dias de Medeiros Cirilo Costa

2017-03-01

Full Text Available Introduction: Leptospirosis is an acute bacterial disease, that has global distribution and manifests itself in subclinical or asymptomatic way, having mild or severe conditions that can lead to the death of the patient. Objective: To identify, among the municipalities of the state of Acre, Brazil, those with the highest incidence of leptospirosis between 2010 and 2015, and in addition, to determine the prevalence of this disease between the sexes. Methods: Descriptive study, of documentary character, with epidemiological base and quantitative approach. It was made by available documents through the Department of Informatics of the Unified Health System of Brazil (DATASUS and also by the Health Secretary of State of Acre (SESACRE. Variables were selected as sex, age and year of notification. Regarding the analysis, it is emphasized that it was quantitative and descriptive and the results were presented in tables built in Microsoft Word. Results: It was found that the capital of the state of Acre, Rio Branco, led every year, contributing to the higher proportion of notifications related to leptospirosis. Regarding gender, there was a predilection for males and among age groups, the period of 20 to 39 years contributes to the greater number of cases of the disease. Conclusion: Leptospirosis is a worldwide public health problem and in the state of Acre, the high rainfall, the agglomeration of low income combined with inadequate sanitation, collaborate to infestation of transmitters animals, providing high rates of the disease. Thus, it appears that these high numbers can probably be attributed to the ineffectiveness of preventive activities, as well as insufficient investment directed to social policies and infrastructure sectors. Keywords: Infectious Disease. Leptospirosis. Prevalence. Incidence.

Site Characterization Work Plan for Gnome-Coach Site, New Mexico

Energy Technology Data Exchange (ETDEWEB)

DOE/NV

2001-02-13

Project Gnome was the first nuclear experiment conducted under the U.S. Atomic Energy Commission (AEC), predecessor to the U.S. Department of Energy (DOE), Plowshare Program. Gnome was part of a joint government-industry experiment focused on developing nuclear devices exclusively for peaceful purposes. The intent of the Gnome experiment was to evaluate the effects of a nuclear detonation in a salt medium. Historically, Project Gnome consisted of a single detonation of a nuclear device on December 10, 1961. Since the Gnome detonation, the AEC/DOE has conducted surface restoration, site reconnaissance, and decontamination and decommissioning activities at the site. In addition, annual groundwater sampling is performed under a long-term hydrological monitoring program begun in 1980. Coach, an experiment to be located near the Gnome project, was initially scheduled for 1963. Although construction and rehabilitation were completed for Coach, the experiment was canceled and never executed. Known collectively as Project Gnome-Coach, the site is situated within the Salado Formation approximately 25 miles east of Carlsbad, New Mexico, in Eddy County, and is comprised of nearly 680 acres, of which 60 acres are disturbed from the combined AEC/DOE operations. The scope of this work plan is to document the environmental objectives and the proposed technical site investigation strategies that will be utilized for the site characterization of the project. The subsurface at the Gnome-Coach site has two contaminant sources that are fundamentally different in terms of both their stratigraphic location and release mechanism. The goal of this characterization is to collect data of sufficient quantity and quality to establish current site conditions and to use the data to identify and evaluate if further action is required to protect human health and the environment and achieve permanent closure of the site. The results of these activities will be presented in a subsequent corrective

1999 SITE ENVIRONMENTAL REPORT

Energy Technology Data Exchange (ETDEWEB)

ENGEL-COX,J.; ZIMMERMAN,E.; LEE,R.; WILLIAMS,J.; GREEN,T.; PAQUETTE,D.; HOODA,B.; SCARPITTA,S.; GENZER,P.; ET AL

2000-09-01

Throughout the scientific community, Brookhaven National Laboratory (BNL) is renowned for its leading-edge research in physics, medicine, chemistry, biology, materials, and the environment. BNL is committed to supporting its world-class scientific research with an internationally recognized environmental protection program. The 1999 Site Environmental Report (SER) summarizes the status of the Laboratory's environmental programs and performance, including the steady progress towards cleaning up the site and fully integrating environmental stewardship into all facets of the Laboratory's mission. BNL is located on 5,265 acres of pine barrens in Suffolk County in the center of Long Island, New York. The Laboratory is situated above a sole source aquifer at the headwaters of the Peconic River; therefore, protecting ground and surface water quality is a special concern. Approximately 3,600 acres of the site are undeveloped and serve as habitat for a wide variety of animals and plants, including one New York State endangered species, the tiger salamander, and two New York State threatened species, the banded sunfish and the stiff goldenrod. Monitoring, preserving, and restoring these ecological resources is a high priority for the Laboratory.

The 2017 ACR Workforce Survey: Management Trends and Strategic Needs.

Science.gov (United States)

Harolds, Jay A; Bluth, Edward I

2018-03-01

The 2017 ACR Workforce Survey included questions for group leaders about management trends and areas in which they need more help from the ACR. Respondents identified point of care ultrasound as the area in which they need the most help. Most respondents gave positive or neutral answers regarding their role in the management of radiology allied health professionals and radiology information technology, and most believed their role and influence in decision making in the organization were not decreasing. Copyright © 2017 American College of Radiology. Published by Elsevier Inc. All rights reserved.

A Report to Congress on Long-Term Stewardship. Volume II, Site Summaries

Energy Technology Data Exchange (ETDEWEB)

None, None

2001-01-01

During World War II and the Cold War, the Federal government developed and operated a vast network of industrial facilities for the research, production, and testing of nuclear weapons, as well as for other scientific and engineering research. These processes left a legacy of radioactive and chemical waste, environmental contamination, and hazardous facilities and materials at well over a 100 sites in 30 States and one U.S. Territory. Hundreds of thousand of acres of residually contaminated soils, contaminated groundwater, surface water and sediment contamination, and contaminated buildings are present at many sites across the country. These sites range in size from less than one acre, containing only a single facility, to large sites spanning over 100,000 acres with huge uranium enrichment plants and plutonium processing canyons. Since 1989, the U.S. Department of Energy’s (DOE) Environmental Management (EM) program has made significant progress in addressing this environmental legacy. Millions of cubic meters of waste have been removed, stabilized, or disposed of, resulting in significant risk and cost reduction. In addition, DOE began disposing of transuranic (i.e., plutonium-contaminated) waste in the nation’s first deep geologic repository – the Waste Isolation Pilot Plant in New Mexico. DOE is now carrying out its long-term stewardship obligations at dozens of sites, including smaller sites where DOE has completed cleanup work for the entire site and many larger sites where DOE has remediated portions of the site.

The application of ZED-2 data in the design and analysis of the ACR-1000

International Nuclear Information System (INIS)

Dweiri, Y.

2011-01-01

The presentation discusses how data obtained from experiments performed in the ZED-2 Critical Facility at Atomic Energy of Canada Limited's Chalk River Laboratories is used in the design and analysis of the ACR-1000. The ACR-1000 design is an evolutionary advancement of the well-established CANDU Reactor technology to Generation 3+. When key core physics parameters for the ACR-1000 are calculated, biases and uncertainties in using the reactor physics toolset WIMS AECL/DRAGON/RFSP and MCNP must be quantified to be able to appropriately assess safety margins in the design. A unique feature of ZED-2 is the ability to perform a wide variety of experiments which is important in providing data that is used in the design and analysis of the ACR-1000. The ACR-1000 was designed to have a small and slightly negative coolant-void-reactivity (CVR), which provides an inherent safety characteristic to mitigate the reactivity transient under any postulated loss-of-coolant accident (LOCA) scenarios. The bias and uncertainty for CVR (full and checkerboard) calculations, derived through comparisons with experimental data, is pivotal to assess the accuracy of the predicted CVR value. This bias and uncertainty is also used in important LOCA analysis to demonstrate the safety features of the ACR-1000. This crucial physics information is available through experiments performed in ZED-2. Other important data that is obtained from ZED-2 in assessing core design pertains to end-flux peaking and in-core flux detector response. The end-region configuration of ACR fuel bundles is an important component of the design, as the axial power distribution within the bundle is not uniform. Detector response in an ACR flux spectrum is important to determine the suitability of safety system detectors when used in the ACR-1000 core. These applications demonstrate the versatility of ZED-2 in providing important reactor physics data makes this critical facility indispensible in current and future R and D

Optimization Evaluation: Lee Chemical Superfund Site, City Of Liberty, Clay County, Missouri

Science.gov (United States)

The Lee Chemical Superfund Site (site) is located along Missouri Highway 210 in Liberty, Missouri, approximately 15 miles east of Kansas City, Missouri. Currently, the site is a vacant lot of approximately2.5 acres in a flat alluvial plain.

EULAR definition of erosive disease in light of the 2010 ACR/EULAR rheumatoid arthritis classification criteria.

Science.gov (United States)

van der Heijde, Désirée; van der Helm-van Mil, Annette H M; Aletaha, Daniel; Bingham, Clifton O; Burmester, Gerd R; Dougados, Maxime; Emery, Paul; Felson, David; Knevel, Rachel; Kvien, Tore K; Landewé, Robert B M; Lukas, Cédric; McInnes, Iain; Silman, Alan J; Smolen, Josef S; Stanislawska-Biernat, Ewa; Zink, Angela; Combe, Bernard

2013-04-01

The aim of this report was to propose a definition for erosive disease in the context of inflammatory arthritis in light of the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) rheumatoid arthritis (RA) criteria for use in clinical practice and studies. A EULAR task force was formed including 16 rheumatologists and one rheumatology fellow. The process was both evidence based and consensus based, and included, between March 2010 and April 2012, analyses of data from two cohorts, two face-to-face meetings, one online voting and one teleconference. The Leiden Early Arthritis Cohort and the French ESPOIR cohort were used for the evidence-based part. The outcome measures, which were initiation of methotrexate therapy, or any disease-modifying antirheumatic drug therapy within the first year of disease and arthritis persistency over 5 years, were studied with the aim to give the best definition of erosive disease. A decision was made to select a definition with a high specificity and focus on patients who did not otherwise fulfil the 2010 ACR/EULAR RA criteria (definition was selected: erosive disease for use in the 2010 ACR/EULAR RA classification criteria is defined when an erosion (defined as a cortical break) is seen in at least three separate joints at any of the following sites: the proximal interphalangeal, the metacarpophalangeal, the wrist (counted as one joint) and the metatarsophalangeal joints on radiographs of both hands and feet. A highly specific definition for erosive disease has thus been formulated.

Using the ACR/NEMA standard with TCP/IP and Ethernet

Science.gov (United States)

Chimiak, William J.; Williams, Rodney C.

1991-07-01

There is a need for a consolidated picture archival and communications system (PACS) in hospitals. At the Bowman Gray School of Medicine of Wake Forest University (BGSM), the authors are enhancing the ACR/NEMA Version 2 protocol using UNIX sockets and TCP/IP to greatly improve connectivity. Initially, nuclear medicine studies using gamma cameras are to be sent to PACS. The ACR/NEMA Version 2 protocol provides the functionality of the upper three layers of the open system interconnection (OSI) model in this implementation. The images, imaging equipment information, and patient information are then sent in ACR/NEMA format to a software socket. From there it is handed to the TCP/IP protocol, which provides the transport and network service. TCP/IP, in turn, uses the services of IEEE 802.3 (Ethernet) to complete the connectivity. The advantage of this implementation is threefold: (1) Only one I/O port is consumed by numerous nuclear medicine cameras, instead of a physical port for each camera. (2) Standard protocols are used which maximize interoperability with ACR/NEMA compliant PACSs. (3) The use of sockets allows a migration path to the transport and networking services of OSIs TP4 and connectionless network service as well as the high-performance protocol being considered by the American National Standards Institute (ANSI) and the International Standards Organization (ISO) -- the Xpress Transfer Protocol (XTP). The use of sockets also gives access to ANSI's Fiber Distributed Data Interface (FDDI) as well as other high-speed network standards.

The radiology job market: analysis of the ACR jobs board.

Science.gov (United States)

Prabhakar, Anand M; Oklu, Rahmi; Harvey, H Benjamin; Harisinghani, Mukesh G; Rosman, David A

2014-05-01

The aim of this study was to assess the status of the radiology job market as represented by the ACR Jobs Board from October 2010 to June 2013. With the assistance of the ACR, data from the ACR Jobs Board from October 2010 through June 2013, including the numbers of monthly new job seekers, new job postings, and job posting clicks, were gathered and used to calculate a monthly competitive index, defined as the ratio of new job seekers to new job postings. During the study period, the mean number of new job seekers was 168 per month, which was significantly greater than the 84 average new job postings for any given month (P = .0002). There was no significant difference between 2011 and 2012 with regard to the number of new job seekers or job postings. Over the time period assessed, more new job seekers registered in October and November 2010, August to November 2011, and October and November 2012. These periods were also associated with the highest competitive index values. There were less job seekers in the winter and spring of 2011, 2012, and 2013, periods associated with lower competitive index values. ACR Jobs Board activity, measured by job posting clicks, was significantly higher in 2012 than in 2011 (P Jobs Board, there were consistently more new job seekers than job postings throughout the study period, and fall is the period in the year most associated with the highest competitive index for radiologist employment. Copyright © 2014 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Breast imaging and reporting data system - Mammography. ACR BI-RADS registered -Mammography

International Nuclear Information System (INIS)

Fischer, U.; Helbrich, T.

2006-01-01

ACR BI-RADS registered mammography is an established technique in all German-speaking countries and has become a standard part of all mammographic findings. The first German-language edition three years ago made a significant contribution to this. This is the second, revised and edited edition. It is based on the fourth English-language edition of the ACR which was published in 2003. (orig.)

The ACR: Advanced design features for a short construction schedule

International Nuclear Information System (INIS)

Elgohary, M.; Fairclough, N.

2003-01-01

Building on the successful CANDU construction at Qinshan, the ACR-700 is designed with constructability considerations as a major requirement during all project phases from the concept design stage to the detail design stage. A project schedule of 48 months has been developed for the nth ACR unit with a 36 months construction period from First Concrete to Fuel Load. This paper describes some of the advanced design features implemented in the reactor building design in order to achieve this short construction period. These features include large volume concrete pours, prefabricated rebar, composite structures, prefabricated permanent formwork and significant modularization and prefabrication

76 FR 26775 - Advisory Committee on Reactor Safeguards Meeting of the ACRS Subcommittee on EPR; Cancellation to...

Science.gov (United States)

2011-05-09

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards Meeting of the ACRS Subcommittee on EPR; Cancellation to May 11, 2011, ACRS Meeting-- Federal Register Notice The Federal Register Notice for the ACRS Subcommittee Meeting on the design certification application review of the U.S...

Lack of AcrB Efflux Function Confers Loss of Virulence on Salmonella enterica Serovar Typhimurium

Directory of Open Access Journals (Sweden)

Xuan Wang-Kan

2017-07-01

Full Text Available AcrAB-TolC is the paradigm resistance-nodulation-division (RND multidrug resistance efflux system in Gram-negative bacteria, with AcrB being the pump protein in this complex. We constructed a nonfunctional AcrB mutant by replacing D408, a highly conserved residue essential for proton translocation. Western blotting confirmed that the AcrB D408A mutant had the same native level of expression of AcrB as the parental strain. The mutant had no growth deficiencies in rich or minimal medium. However, compared with wild-type SL1344, the mutant had increased accumulation of Hoechst 33342 dye and decreased efflux of ethidium bromide and was multidrug hypersusceptible. The D408A mutant was attenuated in vivo in mouse and Galleria mellonella models and showed significantly reduced invasion into intestinal epithelial cells and macrophages in vitro. A dose-dependent inhibition of invasion was also observed when two different efflux pump inhibitors were added to the wild-type strain during infection of epithelial cells. RNA sequencing (RNA-seq revealed downregulation of bacterial factors necessary for infection, including those in the Salmonella pathogenicity islands 1, 2, and 4; quorum sensing genes; and phoPQ. Several general stress response genes were upregulated, probably due to retention of noxious molecules inside the bacterium. Unlike loss of AcrB protein, loss of efflux function did not induce overexpression of other RND efflux pumps. Our data suggest that gene deletion mutants are unsuitable for studying membrane transporters and, importantly, that inhibitors of AcrB efflux function will not induce expression of other RND pumps.

Weldon Spring, Missouri, Site Annual Report for Calendar Year 2015 June 2016

Energy Technology Data Exchange (ETDEWEB)

Starr, Ken [U.S. Dept. of Energy, Washington, DC (United States). Office of Legacy Management (LM); Deyo, Yvonne [Navarro Research and Engineering, Inc., Oak Ridge, TN (United States)

2016-06-01

1.1 Purpose and Scope. This report summarizes the activities, compliance status, annual inspection, and environmental monitoring results from calendar year 2015 for the Weldon Spring, Missouri, Site. The U.S. Department of Energy (DOE) prepares this annual report as part of the site’s long-term surveillance and maintenance (LTS&M) activities, in accordance with the requirements of the Long-Term Surveillance and Maintenance Plan for the Weldon Spring, Missouri, Site (LTS&M Plan) (DOE 2008a) and the Federal Facility Agreement for the Weldon Spring Site (DOE 2006). The Weldon Spring site is a Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) site. 1.2 Site Description. The Weldon Spring site is located in St. Charles County, Missouri, about 30 miles west of St. Louis, Missouri (Figure 1). The site comprises two geographically distinct, DOE-owned properties: the former Weldon Spring Chemical Plant and Raffinate Pit sites (Chemical Plant) and the former Weldon Spring Quarry (Quarry). The former Chemical Plant is located about 2 miles southwest of the junction of Missouri State Route 94 and Interstate 64. The Quarry is about 4 miles southwest of the former Chemical Plant. Both sites are accessible from Missouri State Route 94. During the early 1940s, the Department of the Army acquired 17,232 acres of private land in St. Charles County for the construction of the Weldon Spring Ordnance Works facility. The former Ordnance Works site has since been divided into several contiguous areas under different ownership, as depicted in Figure 2. Current land use of the former Ordnance Works site includes the former Chemical Plant and Quarry, the U.S. Army Reserve Weldon Spring Training Area, the Missouri Department of Conservation (MDC), the Missouri Department of Natural Resources (MDNR) Division of State Parks (MDNR-Parks), Francis Howell High School, a St. Charles County highway maintenance (formerly Missouri Department of Transportation [Mo

Proceedings of the 1977 Isabelle Summer Workshop. [Seventy-four papers

Energy Technology Data Exchange (ETDEWEB)

None

1977-07-18

A report is given of the activities of the 1977 ISABELLE Summer Workshop, held from July 18 to 29, 1977 at the Brookhaven National Laboratory. An abstract was prepared for each of the seventy-four separate presentations for inclusion in DOE Energy Research Abstracts (ERA). (PMA)

Floodplain/wetlands assessment for the remediation of Vicinity Property 9 at the Weldon Spring Site, Weldon Spring, Missouri

International Nuclear Information System (INIS)

Lonkhuyzen, R.A. Van

1995-11-01

The US Department of Energy (DOE) proposes to excavate contaminated soil at Vicinity Property 9 (VP9), a 0.64-ha (1.6-acre) parcel near the Weldon Spring Site in Missouri. A palustrine wetland approximately 0.10 ha (0.25 acre) in size within VP9 would be excavated. Site restoration should allow palustrine wetland to become reestablished. No long-term impacts to floodplains are expected

Technology implementation and cleanup progress at Savannah River site

International Nuclear Information System (INIS)

Papouchado, L.M.

1996-01-01

The integrated high level waste treatment system at Savannah River has started up and the process of converting 34 million gallons of liquid waste to glass and saltstone is in its initial phase. New waste disposal vaults and startup of several other facilities such as the Consolidated Incinerator Facility and a mixed waste vitrification facility will help completion of the integrated system to treat and dispose of SRS wastes. Technology was utilized from industry, other laboratories, or was developed at the Savannah River Technology Center if it was not available. Many SRTC developments involved academia and other labs. SRS also has over 400 waste sites (400 acres) in its characterization/remediation program. To date over 90 acres were remediated (23 percent) and by 1997 we plan to remediate 175 acres or 44 percent. Thirteen groundwater facility treatment sites will be in operation by 1997. SRS has provided and continues to provide unique test platforms for testing innovative remediation, characterization and monitoring technologies. We are currently testing DNAPL characterization and remediation and an in-situ Inorganic remediation technique for ground water

Sensitivity of Escherichia coli acrA Mutants to Psoralen plus Near-Ultraviolet Radiation

DEFF Research Database (Denmark)

Hansen, M. Trier

1982-01-01

The sensitivity to psoralen plus near-ultraviolet radiation (PUVA) was compared in a pair of E. coli strains differing at the acrA locus. Survival was determined for both bacteria and phage λ. AcrA mutant cells were 40 times more sensitive than wild type to the lethal effect of PUVA. Free λ phage...

Substrate binding accelerates the conformational transitions and substrate dissociation in multidrug efflux transporter AcrB

Directory of Open Access Journals (Sweden)

Beibei eWang

2015-04-01

Full Text Available The tripartite efflux pump assembly AcrAB-TolC is the major multidrug resistance transporter in E. coli. The inner membrane transporter AcrB is a homotrimer, energized by the proton movement down the transmembrane electrochemical gradient. The asymmetric crystal structures of AcrB with three monomers in distinct conformational states (access (A, binding (B and extrusion (E support a functional rotating mechanism, in which each monomer of AcrB cycles among the three states in a concerted way. However, the relationship between the conformational changes during functional rotation and drug translocation has not been totally understood. Here, we explored the conformational changes of the AcrB homotrimer during the ABE→BEA transition in different substrate-binding states using targeted MD simulations. It was found that the dissociation of substrate from the distal binding pocket of B monomer is closely related to the concerted conformational changes in the translocation pathway, especially the side chain reorientation of Phe628 and Tyr327. A second substrate binding at the proximal binding pocket of A monomer evidently accelerates the conformational transitions as well as substrate dissociation in B monomer. The acceleration effect of the multi-substrate binding mode provides a molecular explanation for the positive cooperativity observed in the kinetic studies of substrate efflux and deepens our understanding of the functional rotating mechanism of AcrB.

Discos de acresção em sistemas Be-X

Science.gov (United States)

Lopes de Oliveira, R.; Janot-Pacheco, E.

2003-08-01

Alguns fenômenos de outbursts em Be-X sugerem a existência, mesmo que temporária, de um disco de acresção quando da passagem do objeto compacto pelo periastro orbital. Neste trabalho avaliamos a possibilidade de formação do disco de acresção em sistemas Be+estrela de neutrons e Be+anã branca, e a influência da excentricidade orbital na ocorrência deste fenômeno. Utilizamos a expressão analítica para o momento angular específico da matéria constituinte de um meio em expansão lenta, como é o caso do disco circunstelar das estrelas Be, proposta por Wang(1981), sob a condição básica de que o raio de circularização deva ser maior do que o raio de Alfvén. Concluímos que existe um limite para o período orbital do sistema acima do qual não é possível a formação do disco de acresção, e que este valor aumenta para sistemas com excentricidade orbital maior.

Engineering arsenic tolerance and hyperaccumulation in plants for phytoremediation by a PvACR3 transgenic approach.

Science.gov (United States)

Chen, Yanshan; Xu, Wenzhong; Shen, Hongling; Yan, Huili; Xu, Wenxiu; He, Zhenyan; Ma, Mi

2013-08-20

Arsenic (As) pollution is a global problem, and the plant-based cleanup of contaminated soils, called phytoremediation, is therefore of great interest. Recently, transgenic approaches have been designed to develop As phytoremediation technologies. Here, we used a one-gene transgenic approach for As tolerance and accumulation in Arabidopsis thaliana . PvACR3, a key arsenite [As(III)] antiporter in the As hyperaccumulator fern Pteris vittata , was expressed in Arabidopsis , driven by the CaMV 35S promoter. In response to As treatment, PvACR3 transgenic plants showed greatly enhanced tolerance. PvACR3 transgenic seeds could even germinate and grow in the presence of 80 μM As(III) or 1200 μM arsenate [As(V)] treatments that were lethal to wild-type seeds. PvACR3 localizes to the plasma membrane in Arabidopsis and increases arsenite efflux into external medium in short-term experiments. Arsenic determination showed that PvACR3 substantially reduced As concentrations in roots and simultaneously increased shoot As under 150 μM As(V). When cultivated in As(V)-containing soil (10 ppm As), transgenic plants accumulated approximately 7.5-fold more As in above-ground tissues than wild-type plants. This study provides important insights into the behavior of PvACR3 and the physiology of As metabolism in plants. Our work also provides a simple and practical PvACR3 transgenic approach for engineering As-tolerant and -hyperaccumulating plants for phytoremediation.

Environmental assessment for double tracks test site, Nevada Test Site, Nye County, Nevada

International Nuclear Information System (INIS)

1996-04-01

The U.S. Department of Energy, Nevada Operations Office (DOE/NV), with appropriate approvals from the U.S. Air Force (USAF), proposes to conduct environmental restoration operations at the Double Tracks test site located on the Nellis Air Force Range (NAFR) in Nye County, Nevada. This environmental assessment (EA) evaluates the potential environmental consequences of four alternative actions for conducting the restoration operation and of the no action alternative. The EA also identifies mitigation measures, where appropriate, designed to protect natural and cultural resources and reduce impacts to human health and safety. The environmental restoration operation at the Double Tracks test site would serve two primary objectives. First, the proposed work would evaluate the effectiveness of future restoration operations involving contamination over larger areas. The project would implement remediation technology options and evaluate how these technologies could be applied to the larger areas of contaminated soils on the Nevada Test Site (NTS), the Tonopah Test Range (TTR), and the NAFR. Second, the remediation would provide for the removal of plutonium contamination down to or below a predetermined level which would require cleanup of 1 hectare (ha) (2.5 acres), for the most likely case, or up to 3.0 ha (7.4 acres) of contaminated soil, for the upper bounding case

Comparison of neutron parameters between a CANDU and ACR reactors; Comparacao de parametros neutronicos entre um reator CANDU e um ACR

Energy Technology Data Exchange (ETDEWEB)

Dias, Gabriel H.P.; Silva, Clarysson A.M. da; Pereira, Claubia, E-mail: gabrielhpd@yahoo.com.br, E-mail: clarysson@nuclear.ufmg.br, E-mail: claubia@nuclear.ufmg.br [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Departamento de Engenharia Nuclear

2017-11-01

CANDU (Canadian Deuterium Uranium) is a type of reactor that uses heavy water (D{sub 2}O) as a moderator and as a refrigerant. Despite having chemical characteristics similar to light water (H{sub 2}O), heavy water has a high moderation ratio for neutrons. This feature enables CANDU to use natural uranium as fuel. However, research has evaluated the possibility of using H{sub 2}O as a refrigerant and D{sub 2}O as a moderator aiming at reducing the volume of heavy water. Such changes would imply the use of lightly enriched uranium due to the presence of H{sub 2}O. In this context, the concept of ACR (Advanced CANDU Reactor) has been developed. This reactor has an innovative design which combines of the current CANDU with the characteristics of PWR (Pressurized Water Reactor) type reactors. Studies by AECL (Atomic Energy Canada Limited) show that compared to CANDU, the ACR presents a cost reduction in construction, improved firing performance, improved operation safety and longer life. The present work aims to evaluate, in steady state, some of the main neutron parameters of CANDU-6 and ACR-1000. The MCNPX 2.6.0 code (Monte Carlo N-Particle eXtended -version 2.6.0) was used to simulate such types of reactors. The results show that the models configured in the MCNPX adequately reproduce the neutron behavior of the studied reactors. These models may be used in future work for analysis of fuel burn and evolution.

OCORRÊNCIA DE Hypsipyla ferrealis Hampson (LEPIDOPTERA: PYRALIDAE EM ANDIROBA NO ESTADO DO ACRE

Directory of Open Access Journals (Sweden)

Rodrigo Souza Santos

2016-01-01

Full Text Available ABSTRACT The occurrence of Hypsipyla ferrealis Hampson was reported in the state of Acre, Brazil, infesting andiroba Retirar as palavras “the county of” da frase, pois municipality é sinônimo de county, ou seja, está em duplicidade no texto esta informação in plastic trays containing moistened sand and placed into a net cage at Embrapa Entomology Laboratory in Acre state. The cage was daily inspected in order to find emerged insects which were identified as Hypsipyla ferrealis , a lepidopteran commonly associated as an andiroba seed pest. This is the first record of this species occurring in andiroba seeds in Acre state.

Design features of ACR in severe accident mitigation

International Nuclear Information System (INIS)

Shapiro, H.; Krishnan, V.S.; Santamaura, P.; Lekakh, B.; Blahnik, C.

2007-01-01

New reactor designs require the evaluation of design alternatives to reduce the radiological risk by preventing severe accidents or by limiting releases from the plant in the event of such accidents. The Advanced CANDU Reactor TM (ACR TM ) design has provisions to prevent and mitigate severe accidents. This paper describes key ACR design features for severe accident mitigation. It provides a high-level overview of the findings to date. Several design provisions have not yet been finalized or decided, but the designers are keenly aware of the SAM concepts and their requirements. The active heat sinks for 'vessels' (i.e., the fuel channels, the calandria vessel, the calandria end-shields and the calandria vault) are all amply capable of dissipating the severe accident heat loads. These heat sinks are designed to be operable under severe accident environmental conditions; however, their operability is yet to be confirmed by assessments. The active heat sinks for the various process vessels are 'backed up' by passive heat sinks (i.e., steaming plus water make-up from the RWS). The supply side of passive heat sinks is simple, rugged, and not vulnerable to failures of plant systems. The importance of the steam relief side is recognized, and the adequate relief capacity will be provided. The passive heat sinks will give the SAM more than 1 day (likely several days) to diagnose the accident and to establish the ultimate heat sinks. The spray system for containment pressure suppression is designed for high reliability and has ample capacity to ensure low containment leakage without external intervention, after which time alternative supply to the sprays can be brought on line manually. The sprays are backed up by the LACs which are assessed for operability following a severe accident. The strong ACR containment will provide a long time of completely passive protection for any severe accident at decay power. Its characteristics are not prone to catastrophic failures. The

Environmental assessment of remedial action at the inactive uraniferous lignite processing sites at Belfield and Bowman, North Dakota

International Nuclear Information System (INIS)

Beranich, S.; Berger, N.; Bierley, D.; Bond, T.M.; Burt, C.; Caldwell, J.A.; Dery, V.A.; Dutcher, A.; Glover, W.A.; Heydenburg, R.J.; Larson, N.B.; Lindsey, G.; Longley, J.M.; Millard, J.B.; Miller, M.; Peel, R.C.; Persson-Reeves, C.H.; Titus, F.B.; Wagner, L.

1989-09-01

The Uranium Mill Tailings Radiation Control Act of 1978 (UMTRCA), to clean up the Belfield and Bowman, North Dakota, uraniferous lignite processing sites to reduce the potential health impacts associated with the residual radioactive materials remaining at these sites. Remedial action at these sites must be performed in accordance with the US Environmental Protection Agency's (EPA) standards promulgated for the remedial action and with the concurrence of the US Nuclear Regulatory Commission (NRC) and the state of North Dakota. The inactive Belfield uraniferous lignite processing site is one mile southeast of Belfield, North Dakota. The inactive Bowman uraniferous lignite processing site at the former town of Griffin, is seven miles northwest of Bowman, North Dakota and 65 road miles south of Belfield. Lignite ash from the processing operations has contaminated the soils over the entire 10.7-acre designated Belfield site and the entire 12.1-acre designated Bowman site. Dispersion of the ash has contaminated an additional 20.6 acres surrounding the Belfield processing site and an additional 59.2 acres surrounding the Bowman processing site. The proposed remedial action is to relocate the contaminated materials at the Belfield processing site to the Bowman processing/disposal site for codisposal with the Bowman contaminated soils. The environmental impacts assessed in this EA were evaluated for the proposed remedial action and the no action alternative and demonstrate that the proposed action would not significantly affect the quality of the human environment and would be performed in compliance with applicable environmental laws. The no action alternative would not be consistent with the intent of Public Law 95-604 and would not comply with the EPA standards. 48 refs., 10 figs., 7 tabs

Characterization of Seismic Noise at Selected Non-Urban Sites

Science.gov (United States)

2010-03-01

Field sites for seismic recordings: Scottish moor (upper left), Enfield, NH (upper right), and vicinity of Keele, England (bottom). ERDC...three sites. The sites are: a wind farm on a remote moor in Scotland, a ~13 acre field bounded by woods in a rural Enfield, NH neigh- borhood, and a site...in a rural Enfield, NH, neighborhood, and a site transitional from developed land to farmland within 1 km of the six-lane M6 motorway near Keele

AcrA suppressor alterations reverse the drug hypersensitivity phenotype of a TolC mutant by inducing TolC aperture opening

Science.gov (United States)

Weeks, Jon W.; Celaya-Kolb, Teresa; Pecora, Sara; Misra, Rajeev

2010-01-01

Summary In Escherichia coli, the TolC–AcrAB complex forms a major antibiotic efflux system with broad substrate specificity. During the complex assembly, the periplasmic helices and bottom turns of TolC are thought to interact with a hairpin helix of AcrA and hairpin loops of AcrB respectively. In the present study we show that a four-residue substitution in TolC’s turn 1, which connects outer helices 3 and 4 proximal to TolC’s periplasmic aperture, confers antibiotic hypersensitivity without affecting TolC-mediated phage or colicin infection. However, despite the null-like drug sensitivity phenotype, chemical cross-linking analysis revealed no apparent defects in the ability of the mutant TolC protein to physically interact with AcrA and AcrB. A role for TolC turn 1 residues in the functional assembly of the tripartite efflux pump complex was uncovered through isolating suppressor mutations of the mutant TolC protein that mapped within acrA and by utilizing a labile AcrA protein. The data showed that AcrA-mediated suppression of antibiotic sensitivity was achieved by dilating the TolC aperture/channel in an AcrB-dependent manner. The results underscore the importance of the periplasmic turn 1 of TolC in the functional assembly of the tripartite efflux complex and AcrA in transitioning TolC from its closed to open state. PMID:20132445

Geochemical exploration for phosphate in the State of Acre

International Nuclear Information System (INIS)

Costa, M.L. da; Melo Costa, W.A. de; Santos, A.J.M. dos

1989-01-01

The geochemical prospecting conducted for phosphates in Acre which could explain the good fertility of the region was charged to discover this material. The phosphates are strictly built of all the bone structures and coprolites of the several fragments of vertebrate fossils, which are widespread in the region. The phosphatic fossils are bedded in the Solimoes Formation, especially its basal to intermediary conglomeratic bed. The fossils are constituted of low crystallinity apatite, and their matrix sediments include quartz, feldspars, smectite, halloysite and calcite. The P 2 O 5 content reaches up to 5% in the sediments and up to 32% in the fragments. The fossils are enriched in U 3 O 8 and rare earth elements. There is no perspect of classic or mineral deposits but the geological knowlwdge will permit the improvement of the use of the soils in Acre. (author) [pt

Morphometric evaluation of Arbor Acre parent stock broilers reared ...

African Journals Online (AJOL)

Morphometric evaluation of Arbor Acre parent stock broilers reared in ... Economic importance of morphometric parameters such as live weight and body ... (R2) value of 60.30 included forecast indices such as BL, WS, WL, TL, BG and SL.

DOE Research Set-Aside Areas of the Savannah River Site

Energy Technology Data Exchange (ETDEWEB)

Davis, C.E.; Janecek, L.L.

1997-08-31

Designated as the first of seven National Environmental Research Parks (NERPs) by the Atomic Energy Commission (now the Department of Energy), the Savannah River Site (SRS) is an important ecological component of the Southeastern Mixed Forest Ecoregion located along the Savannah River south of Aiken, South Carolina. Integral to the Savannah River Site NERP are the DOE Research Set-Aside Areas. Scattered across the SRS, these thirty tracts of land have been set aside for ecological research and are protected from public access and most routine Site maintenance and forest management activities. Ranging in size from 8.5 acres (3.44 ha) to 7,364 acres (2,980 ha), the thirty Set-Aside Areas total 14,005 acres (5,668 ha) and comprise approximately 7% of the Site`s total area. This system of Set-Aside Areas originally was established to represent the major plant communities and habitat types indigenous to the SRS (old-fields, sandhills, upland hardwood, mixed pine/hardwood, bottomland forests, swamp forests, Carolina bays, and fresh water streams and impoundments), as well as to preserve habitats for endangered, threatened, or rare plant and animal populations. Many long-term ecological studies are conducted in the Set-Asides, which also serve as control areas in evaluations of the potential impacts of SRS operations on other regions of the Site. The purpose of this document is to give an historical account of the SRS Set-Aside Program and to provide a descriptive profile of each of the Set-Aside Areas. These descriptions include a narrative for each Area, information on the plant communities and soil types found there, lists of sensitive plants and animals documented from each Area, an account of the ecological research conducted in each Area, locator and resource composition maps, and a list of Site-Use permits and publications associated with each Set-Aside.

Leaching Studies on ACR-1000{sup R} Fuel Under Reactor Operating Conditions

Energy Technology Data Exchange (ETDEWEB)

Sunder, S. [Atomic Energy of Canada Limited, Fuel and Fuel Channel Safety Branch, Chalk River, Ontario, K0J 1J0 (Canada)

2009-06-15

ACR-1000{sup R} is the latest nuclear power reactor being developed by AECL. The ACR-1000 fuel uses a modified CANFLEX{sup R} fuel bundle that contains low-enriched uranium and pellets of burnable neutron absorbers (BNA) in a central element. Dysprosium and gadolinium are used as the burnable neutron absorbers and are present as oxides in a 'fully-stabilized' zirconia matrix. The BNA material in the centre element is designed to limit the coolant void reactivity of the reactor core during postulated loss-of-coolant accidents. As part of the ACR-1000 fuel development, the stability of the BNA material under conditions associated with defects of the Zircaloy sheathing of the BNA central element has been investigated. The results of these tests can be used to demonstrate the phase stability and leaching behaviour of the ACR-1000 fuel under reactor operating conditions. The samples were disks, about 3-4 mm thick, obtained from BNA pellets and Candu fuel (natural uranium UO{sub 2}) pellets (the UO{sub 2} measurements provide a reference point). Leaching tests were carried out in light water at 325 deg. C, above the maximum coolant temperature in an ACR-1000 fuel channel during normal operating conditions (319 deg. C). This temperature also bounds the maximum operating temperature for the current Candu reactors (311 deg. C). The initial pH of the solution (measured at room temperature) used in the leaching tests was 10.3. The leach rates were determined by monitoring the amount of metals leached into solutions. Leaching tests were also carried out with BNA pellet samples in the presence of Zr-2.5%Nb pressure tube coupons to determine the effects, if any, of the presence of pressure tube material on leach rates. Other leaching tests with BNA pellet samples and UO{sub 2} pellets were conducted at 80 deg. C to study the effects of temperature on the leach rates. The temperature of 80 deg. C was selected as representative of typical shutdown temperatures

Development of a platform for interactive training ACRs

International Nuclear Information System (INIS)

Gonzalvo, A.; Martin, J. E.; Herrera, J. A.

2013-01-01

Due to the workload of plant personnel and extension courses, you can use other methods of online learning to complement the methods of classroom learning, so that it minimizes disruption to the day job plant day. GNFE is implementing systems on-line training in ACRs based on MOODLE which has many advantages.

Strategy for 100-year life of the ACR-1000 concrete containment structure

International Nuclear Information System (INIS)

Abrishami, H.; Elgohary, M.

2006-01-01

The purpose of this paper is to present the Plant Life Management (PLiM) strategy for the concrete containment structure of the ACR-1000 (Advanced CANDU Reactor) designed by AECL. The ACR-1000 is designed for 100-year plant life including 60-year operating life and additional 40-year decommissioning period of time. The approach adopted for the PLiM strategy of the concrete containment structure is a preventive one, key areas being: 1) design methodology, 2) material performance and 3) life cycle management and ageing management program. In the design phase, in addition to strength and serviceability, durability is a major requirement during the service life and decommissioning phase of the ACR structure. Parameters affecting durability design include: a) concrete performance, b) structural application, and c) environmental conditions. Due to the complex nature of the environmental effects acting on structures during the service life of project, it is considered that true improved performance during the service life can be achieved by improving the material characteristics. Many recent innovations in advanced concrete materials technology have made it possible to produce modern concrete such as high-performance concrete with exceptional performance characteristics. In this paper, the PLiM strategy for the ACR-1000 concrete containment is presented. In addition to addressing the design methodology and material performance areas, a systematic approach for ageing management program for the concrete containment structure is presented. (author)

Stroke Rehabilitation in Frail Elderly with the Robotic Training Device ACRE: A Randomized Controlled Trial and Cost-Effectiveness Study

Directory of Open Access Journals (Sweden)

M. Schoone

2011-01-01

Full Text Available The ACRE (ACtive REhabilitation robotic device is developed to enhance therapeutic treatment of upper limbs after stroke. The aim of this study is to assess effects and costs of ACRE training for frail elderly patients and to establish if ACRE can be a valuable addition to standard therapy in nursing home rehabilitation. The study was designed as randomized controlled trial, one group receiving therapy as usual and the other receiving additional ACRE training. Changes in motor abilities, stroke impact, quality of life and emotional well-being were assessed. In total, 24 patients were included. In this small number no significant effects of the ACRE training were found. A large number of 136 patients were excluded. Main reasons for exclusion were lack of physiological or cognitive abilities. Further improvement of the ACRE can best be focused on making the system suitable for self-training and development of training software for activities of daily living.

Keynote Address: ACR-NEMA standards and their implications for teleradiology

Science.gov (United States)

Horii, Steven C.

1990-06-01

The ACR-NEMA Standard was developed initially as an interface standard for the interconnection of two pieces of imaging equipment Essentially the Standard defmes a point-to-point hardware connection with the necessary protocol and data structure so that two differing devices which meet the specification will be able to communicate with each other. The Standard does not defme a particular PACS architecture nor does it specify a database structure. In part these are the reasons why implementers have had difficulty in using the Standard in a full PACS. Recent activity of the Working Groups formed by the Committee overseeing work on the ACR-NEMA Standard has changed some of the " flavor" of the Standard. It was realized that connection of PACS with hospital and radiology information systems (HIS and RIS) is necessary if a PACS is ever to be succesful. The idea of interconnecting heterogeneous computer systems has pushed Standards development beyond the scope of the original work. Teleradiology which inherenfly involves wide-area networking may be a direct beneficiary of the new directions taken by the Standards Working Groups. This paper will give a brief history of the ACR-NEMA effort describe the " parent" Standard and its " offspring" and describe the activity of the current Working Groups with particular emphasis on the potential impacts on teleradiology.

Plant life management of the ACR-1000 Concrete containment structure

International Nuclear Information System (INIS)

Abrishami, H.H.; Ricciuti, R.; Elgohary, M.

2009-01-01

The Ageing of reinforced concrete structures due to service conditions, aggressive environments, or accidents may cause their strength, serviceability and durability to decrease over time. For a new plant, a Plant Life Management (PLiM) program should start in the design process and then continues through the plant operation and decommissioning. Hence, PLiM must provide not only Ageing Management program (AMP) but also provide requirements on material characteristic and design criteria as well. The purpose of this paper is to present the Plant Life Management (PLiM) strategy for the concrete containment structure of the ACR-10001 (Advanced CANDU Reactor) designed by AECL. The ACR-1000 is designed for a 100-year plant life including 60-year operating life and an additional 40-year decommissioning period. The approach adopted for the PLiM strategy of the concrete containment structure is a preventive one, key areas being: 1) design methodology, 2) material performance and 3) ageing management program. During the design phase, in addition to strength and serviceability, durability, throughout the service life and decommissioning phase of the ACR-1000 structure, is a major consideration. Factors affecting durability design include: a) concrete performance, b) structural application, and c) consideration of environmental conditions. In addition to addressing the design methodology and material performance requirements, a systematic approach for the ageing management program for the concrete containment structure is presented. (authors)

Ocorrência de Herminodes sp. (Lepidoptera: Noctuidae em pupunheira nos estados do Acre e Rondônia, Brasil Occurrence of Herminodes sp. (Lepidoptera: Noctuidae in peach palm in the States of Acre and Rondônia, Brazil

Directory of Open Access Journals (Sweden)

Marcílio José Thomazini

2004-09-01

Full Text Available É relatado a ocorrência de Herminodes sp. em plantas de pupunha na área experimental da Embrapa Acre, Rio Branco, AC e no Projeto Reca, Vila Nova Califórnia, RO, Brasil. São descritas as principais características deste inseto e os danos por ele causados. Este é o primeiro registro de lagartas do gênero Herminodes causando dano em pupunheiras nos estados do Acre e Rondônia.Related herein is the occurrence of Herminodes sp. in peach palm plants at experimental area of Embrapa Acre, Rio Branco, AC and at Projeto Reca, Vila Nova California, RO, Brazil. The main characteristics of this insect and the damage it causes are described. This is the first record of Herminodes caterpillars damaging peach palm in the states of Acre and Rondônia.

Qualidade da castanha-do-brasil do comércio de Rio Branco, Acre Quality of Brazil nuts marketed in Rio Branco, Acre

Directory of Open Access Journals (Sweden)

Virgínia de Souza Álvares

2012-06-01

Full Text Available Este trabalho teve como objetivo avaliar a qualidade de castanhas-do-brasil beneficiadas e comercializadas em Rio Branco, Acre. Foram analisadas amostras das três marcas de castanha encontradas no mercado local quanto às variáveis: atividade de água, teor de umidade, contagem total de fungos filamentosos, quantificação de Aspergillus flavus e de A. parasiticus, bem como quantificação de aflatoxinas B1, B2, G1 e G2. As castanhas do comércio se encontravam com um teor de umidade e atividade de água adequados, o que pode ter sido responsável pela baixa contaminação por fungos e por aflatoxinas. Quanto a estas micotoxinas, as amostras estão de acordo com o recomendado pela Anvisa, podendo ser esta uma consequência da grande divulgação no Estado do uso de Boas Práticas no manejo da castanha.The goal of this paper was to evaluate the quality of Brazil nuts processed and marketed in the city of Rio Branco, in the state of Acre (Brazil. We analysed three samples for water activity, moisture content, total fungus quantification of Aspergillus flavus and A. parasiticus, as well as quantification of total aflatoxin, Afla B1, Afla B2, Afla G1 and Afla G2. The nut samples from the market showed an appropriate moisture content and water activity, which may have been responsible for the low fungus contamination and aflatoxin production. As to these mycotoxins, the samples were consistent with Anvisa's recommendations, which may be a consequence of good management of the nuts in Acre.

TU-F-CAMPUS-I-04: Head-Only Asymmetric Gradient System Evaluation: ACR Image Quality and Acoustic Noise

Energy Technology Data Exchange (ETDEWEB)

Weavers, P; Shu, Y; Tao, S; Bernstein, M [Mayo Clinic, Rochester, Minnesota (United States); Lee, S; Piel, J; Foo, T [GE Global Research, Niskayuna, NY (United States); Mathieu, J-B [GE Healthcare, Florence, SC (Italy)

2015-06-15

Purpose: A high-performance head-only magnetic resonance imaging gradient system with an acquisition volume of 26 cm employing an asymmetric design for the transverse coils has been developed. It is able to reach a magnitude of 85 mT/m at a slew rate of 700 T/m/s, but operated at 80 mT/m and 500 T/m/s for this test. A challenge resulting from this asymmetric design is that the gradient nonlinearly exhibits both odd- and even-ordered terms, and as the full imaging field of view is often used, the nonlinearity is pronounced. The purpose of this work is to show the system can produce clinically useful images after an on-site gradient nonlinearity calibration and correction, and show that acoustic noise levels fall within non-significant risk (NSR) limits for standard clinical pulse sequences. Methods: The head-only gradient system was inserted into a standard 3T wide-bore scanner without acoustic damping. The ACR phantom was scanned in an 8-channel receive-only head coil and the standard American College of Radiology (ACR) MRI quality control (QC) test was performed. Acoustic noise levels were measured for several standard pulse sequences. Results: Images acquired with the head-only gradient system passed all ACR MR image quality tests; Both even and odd-order gradient distortion correction terms were required for the asymmetric gradients to pass. Acoustic noise measurements were within FDA NSR guidelines of 99 dBA (with assumed 20 dBA hearing protection) A-weighted and 140 dB for peak for all but one sequence. Note the gradient system was installed without any shroud or acoustic batting. We expect final system integration to greatly reduce noise experienced by the patient. Conclusion: A high-performance head-only asymmetric gradient system operating at 80 mT/m and 500 T/m/s conforms to FDA acoustic noise limits in all but one case, and passes all the ACR MR image quality control tests. This work was supported in part by the NIH grant 5R01EB010065.

TU-F-CAMPUS-I-04: Head-Only Asymmetric Gradient System Evaluation: ACR Image Quality and Acoustic Noise

International Nuclear Information System (INIS)

Weavers, P; Shu, Y; Tao, S; Bernstein, M; Lee, S; Piel, J; Foo, T; Mathieu, J-B

2015-01-01

Purpose: A high-performance head-only magnetic resonance imaging gradient system with an acquisition volume of 26 cm employing an asymmetric design for the transverse coils has been developed. It is able to reach a magnitude of 85 mT/m at a slew rate of 700 T/m/s, but operated at 80 mT/m and 500 T/m/s for this test. A challenge resulting from this asymmetric design is that the gradient nonlinearly exhibits both odd- and even-ordered terms, and as the full imaging field of view is often used, the nonlinearity is pronounced. The purpose of this work is to show the system can produce clinically useful images after an on-site gradient nonlinearity calibration and correction, and show that acoustic noise levels fall within non-significant risk (NSR) limits for standard clinical pulse sequences. Methods: The head-only gradient system was inserted into a standard 3T wide-bore scanner without acoustic damping. The ACR phantom was scanned in an 8-channel receive-only head coil and the standard American College of Radiology (ACR) MRI quality control (QC) test was performed. Acoustic noise levels were measured for several standard pulse sequences. Results: Images acquired with the head-only gradient system passed all ACR MR image quality tests; Both even and odd-order gradient distortion correction terms were required for the asymmetric gradients to pass. Acoustic noise measurements were within FDA NSR guidelines of 99 dBA (with assumed 20 dBA hearing protection) A-weighted and 140 dB for peak for all but one sequence. Note the gradient system was installed without any shroud or acoustic batting. We expect final system integration to greatly reduce noise experienced by the patient. Conclusion: A high-performance head-only asymmetric gradient system operating at 80 mT/m and 500 T/m/s conforms to FDA acoustic noise limits in all but one case, and passes all the ACR MR image quality control tests. This work was supported in part by the NIH grant 5R01EB010065

DOE Research Set-Aside Areas of the Savannah River Site

International Nuclear Information System (INIS)

Davis, C.E.; Janecek, L.L.

1997-01-01

Designated as the first of seven National Environmental Research Parks (NERPs) by the Atomic Energy Commission (now the Department of Energy), the Savannah River Site (SRS) is an important ecological component of the Southeastern Mixed Forest Ecoregion located along the Savannah River south of Aiken, South Carolina. Integral to the Savannah River Site NERP are the DOE Research Set-Aside Areas. Scattered across the SRS, these thirty tracts of land have been set aside for ecological research and are protected from public access and most routine Site maintenance and forest management activities. Ranging in size from 8.5 acres (3.44 ha) to 7,364 acres (2,980 ha), the thirty Set-Aside Areas total 14,005 acres (5,668 ha) and comprise approximately 7% of the Site's total area. This system of Set-Aside Areas originally was established to represent the major plant communities and habitat types indigenous to the SRS (old-fields, sandhills, upland hardwood, mixed pine/hardwood, bottomland forests, swamp forests, Carolina bays, and fresh water streams and impoundments), as well as to preserve habitats for endangered, threatened, or rare plant and animal populations. Many long-term ecological studies are conducted in the Set-Asides, which also serve as control areas in evaluations of the potential impacts of SRS operations on other regions of the Site. The purpose of this document is to give an historical account of the SRS Set-Aside Program and to provide a descriptive profile of each of the Set-Aside Areas. These descriptions include a narrative for each Area, information on the plant communities and soil types found there, lists of sensitive plants and animals documented from each Area, an account of the ecological research conducted in each Area, locator and resource composition maps, and a list of Site-Use permits and publications associated with each Set-Aside

Site Characterization Work Plan for the Gnome-Coach Site, New Mexico (Rev. 1, January 2002)

Energy Technology Data Exchange (ETDEWEB)

U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office (NNSA/NV)

2002-01-14

Project Gnome was the first nuclear experiment conducted under the U.S. Atomic Energy Commission (AEC), predecessor to the U.S. Department of Energy (DOE), Plowshare Program. The Plowshare Program focused on developing nuclear devices exclusively for peaceful purposes. The intent of the Gnome experiment was to evaluate the effects of a nuclear detonation in a salt medium. Historically, Project Gnome consisted of a single detonation of a nuclear device on December 10, 1961 with the Salado Formation. Since the Gnome detonation, the AEC/DOE has conducted surface restoration, site reconnaissance, and decontamination and decommissioning activities at the site. In addition, annual groundwater sampling is performed under a long-term hydrological monitoring program begun in 1972. Coach, an experiment to be located near the Gnome project, was initially scheduled for 1963. Although construction and rehabilitation were completed for Coach, the experiment was canceled and never executed. Known collectively as Project Gnome-Coach, the site is located approximately 25 miles east of Carlsbad, New Mexico, in Eddy County, and is comprised of nearly 680 acres, of which approximately 60 acres are disturbed from the combined AEC/DOE operations. The scope of this work plan is to document the environmental objectives and the proposed technical site investigation strategies that will be utilized for the site characterization of the project. The subsurface at the Gnome-Coach site has two contaminant sources that are fundamentally different in terms of both their stratigraphic location and release mechanism. The goal of this characterization is to collect data of sufficient quantity and quality to establish current site conditions and to use the data to identify and evaluate if further action is required to protect human health and the environment and achieve permanent closure of the site. The results of these activities will be presented in a subsequent corrective action decision document.

77 FR 75144 - Foreign-Trade Zone 277-Western Maricopa County, AZ; Application for Expansion; (New Magnet Site...

Science.gov (United States)

2012-12-19

... Maricopa County, AZ; Application for Expansion; (New Magnet Site) Under Alternative Site Framework An... additional new magnet sites in western Maricopa County, Arizona and request usage-driven designation for an..., Arizona. The current zone project includes the following magnet sites: Site 1 (230.25 acres)--within the...

Methodology for predicting ultimate pressure capacity of the ACR-1000 containment structure

International Nuclear Information System (INIS)

Saudy, A.M.; Awad, A.; Elgohary, M.

2006-01-01

The Advanced CANDU Reactor or the ACR-1000 is developed by Atomic Energy of Canada Limited (AECL) to be the next step in the evolution of the CANDU product line. It is based on the proven CANDU technology and incorporates advanced design technologies. The ACR containment structure is an essential element of the overall defense in depth approach to reactor safety, and is a physical barrier against the release of radioactive material to the environment. Therefore, it is important to provide a robust design with an adequate margin of safety. One of the key design requirements of the ACR containment structure is to have an ultimate pressure capacity that is at least twice the design pressure Using standard design codes, the containment structure is expected to behave elastically at least up to 1.5 times the design pressure. Beyond this pressure level, the concrete containment structure with reinforcements and post-tension tendons behaves in a highly non-linear manner and exhibits a complex response when cracks initiate and propagate. To predict the structural non-linear responses, at least two critical features are involved. These are: the structural idealization by the geometry and material property models, and the adopted solution algorithm. Therefore, detailed idealization of the concrete structure is needed in order to accurately predict its ultimate pressure capacity. This paper summarizes the analysis methodology to be carried out to establish the ultimate pressure capacity of the ACR containment structure and to confirm that the structure meets the specified design requirements. (author)

Site recycling: From Brownfield to football field

Energy Technology Data Exchange (ETDEWEB)

Lee, C.; Haas, W.L. [HDR Engineering Inc., Charlotte, NC (United States)

1995-07-01

The Carolina Panther`s new home, Carolinas Stadium, will be impressive. It will include a 75,000-seat stadium, about 2,000 parking spaces, and a practice facility equipped with three full-sized football fields, all located on 30 acres bordering the central business district of Charlotte, NC. Fans of the NFL expansion team may never know that, until recently, 13 of those 30 acres were a former state Superfund site contaminated by a commercial scrapyard that had operated from the early 1930s to 1983. The salvage of nonferrous metals from lead-acid batteries, copper from transformers and other electrical equipment, and ferrous metal scrap from junk automobiles at the Smith Metal and Iron (SMI) site had left a complex contamination legacy. The soil contained lead, polychlorinated biphenyls (PCBs), lesser amounts of semivolatiles (polyaromatic hydrocarbons, or PAHs), and volatile organic compounds and petroleum hydrocarbons. The site had remained dormant, like many former industrial sites that have come be called {open_quotes}brownfields,{close_quotes} for nearly a decade when in 1993, Charlotte was selected as the future home of the Carolina Panthers, a National Football League expansion team. The city was able to attract the team in part by offering to redevelop the site, a prime location adjacent to the downtown area. An eight-month-long site remediation effort by HDR Engineering Inc. was completed March 31, on schedule for a June 1996 unveiling of the team`s new facility.

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the regulator AcrR from Escherichia coli

International Nuclear Information System (INIS)

Li, Ming; Qiu, Xi; Su, Chih-Chia; Long, Feng; Gu, Ruoyu; McDermott, Gerry; Yu, Edward W.

2006-01-01

The transcriptional regulator AcrR from Escherichia coli has been cloned, overexpressed, purified and crystallized and X-ray diffraction data have been collected to a resolution of 2.5 Å. This paper describes the cloning, expression, purification and preliminary X-ray data analysis of the AcrR regulatory protein. The Escherichia coli AcrR is a member of the TetR family of transcriptional regulators. It regulates the expression of the AcrAB multidrug transporter. Recombinant AcrR with a 6×His tag at the C-terminus was expressed in E. coli and purified by metal-affinity chromatography. The protein was crystallized using hanging-drop vapor diffusion. X-ray diffraction data were collected from cryocooled crystals at a synchrotron light source. The best crystal diffracted to 2.5 Å. The space group was determined to be P3 2 , with unit-cell parameters a = b = 46.61, c = 166.16 Å

Furfural and hydroxymethylfurfural tolerance in Escherichia coli ΔacrR regulatory mutants.

Science.gov (United States)

Luhe, Annette Lin; Lim, Chan Yuen; Gerken, Henri; Wu, Jinchuan; Zhao, Hua

2015-01-01

The presence of the highly toxic furfural and hydroxymethylfurfural (HMF) in the hydrolysate of lignocellulosic biomass prompted the investigation of the Escherichia coli ΔacrR regulatory mutant for higher tolerance to these compounds, to facilitate the production of biofuels and biochemicals, and further biocatalytic conversions. In comparison with the parental strain, the regulatory mutant with the upregulated efflux pump AcrAB-TolC produced moderately better growth and higher tolerance to concentrations of furfural and HMF between 1 and 2 g L(-1) . © 2014 International Union of Biochemistry and Molecular Biology, Inc.

Seventy years of incineration

Energy Technology Data Exchange (ETDEWEB)

Dumbleton, Brian

1995-06-08

A third waste incineration plant, which will conform to new United Kingdom emission standards is currently under construction at Tyseley in Birmingham. The plant will generate 25MW of electricity for 25,000 households by burning 350,000 t of municipal wastes per year. The site has been used for such energy from waste schemes since 1926. The new plant includes the latest air pollution abatement equipment designed to absorb mercury vapour and dioxins together with fabric filters. Other improvements at the Tyseley site include a new purpose built public waste disposal facility, clinical waste and animal carcass incineration and the recovery of 16,000t of ferrous metals per year for recycling. Because these waste products are incinerated it also therefore reduce`s Birmingham`s need for landfill sites. (UK)

Remedial action at the Green River uranium mill tailings site, Green River, Utah: Environmental assessment

International Nuclear Information System (INIS)

1988-07-01

The inactive Green River uranium mill tailings site is one mile southeast of Green River, Utah. The existing tailings pile is within the floodplain boundaries of the 100-year and 500-year flood events. The 48-acre designated site contains eight acres of tailings, the mill yard and ore storage area, four main buildings, a water tower, and several small buildings. Dispersion of the tailings has contaminated an additional 24 acres surrounding the designated site. Elevated concentrations of molybdenum, nitrate, selenium, uranium, and gross alpha activity exceed background levels and the proposed US Environmental Protection Agency (EPA) maximum concentration limits in the groundwater in the unconsolidated alluvium and in the shallow shales and limestones beneath the alluvium at the mill tailings site. The contamination is localized beneath, and slightly downgradient of, the tailings pile. The proposed action is to relocate the tailings and associated contaminated materials to an area 600 feet south of the existing tailings pile where they would be consolidated into one, below-grade disposal cell. A radon/infiltration barrier would be constructed to cover the stabilized pile and various erosion control measures would be taken to ensure the long-term stability of the stabilized pile. 88 refs., 12 figs., 20 tabs

Site Characterization Work Plan for the Gnome-Coach Site, New Mexico (Rev. 1, January 2002); FINAL

International Nuclear Information System (INIS)

2002-01-01

Project Gnome was the first nuclear experiment conducted under the U.S. Atomic Energy Commission (AEC), predecessor to the U.S. Department of Energy (DOE), Plowshare Program. The Plowshare Program focused on developing nuclear devices exclusively for peaceful purposes. The intent of the Gnome experiment was to evaluate the effects of a nuclear detonation in a salt medium. Historically, Project Gnome consisted of a single detonation of a nuclear device on December 10, 1961 with the Salado Formation. Since the Gnome detonation, the AEC/DOE has conducted surface restoration, site reconnaissance, and decontamination and decommissioning activities at the site. In addition, annual groundwater sampling is performed under a long-term hydrological monitoring program begun in 1972. Coach, an experiment to be located near the Gnome project, was initially scheduled for 1963. Although construction and rehabilitation were completed for Coach, the experiment was canceled and never executed. Known collectively as Project Gnome-Coach, the site is located approximately 25 miles east of Carlsbad, New Mexico, in Eddy County, and is comprised of nearly 680 acres, of which approximately 60 acres are disturbed from the combined AEC/DOE operations. The scope of this work plan is to document the environmental objectives and the proposed technical site investigation strategies that will be utilized for the site characterization of the project. The subsurface at the Gnome-Coach site has two contaminant sources that are fundamentally different in terms of both their stratigraphic location and release mechanism. The goal of this characterization is to collect data of sufficient quantity and quality to establish current site conditions and to use the data to identify and evaluate if further action is required to protect human health and the environment and achieve permanent closure of the site. The results of these activities will be presented in a subsequent corrective action decision document

Mediator, SWI/SNF and SAGA complexes regulate Yap8-dependent transcriptional activation of ACR2 in response to arsenate.

Science.gov (United States)

Menezes, Regina Andrade; Pimentel, Catarina; Silva, Ana Rita Courelas; Amaral, Catarina; Merhej, Jawad; Devaux, Frédéric; Rodrigues-Pousada, Claudina

2017-04-01

Response to arsenic stress in Saccharomyces cerevisiae is orchestrated by the regulatory protein Yap8, which mediates transcriptional activation of ACR2 and ACR3. This study contributes to the state of art knowledge of the molecular mechanisms underlying yeast stress response to arsenate as it provides the genetic and biochemical evidences that Yap8, through cysteine residues 132, 137, and 274, is the sensor of presence of arsenate in the cytosol. Moreover, it is here reported for the first time the essential role of the Mediator complex in the transcriptional activation of ACR2 by Yap8. Based on our data, we propose an order-of-function map to recapitulate the sequence of events taking place in cells injured with arsenate. Modification of the sulfhydryl state of these cysteines converts Yap8 in its activated form, triggering the recruitment of the Mediator complex to the ACR2/ACR3 promoter, through the interaction with the tail subunit Med2. The Mediator complex then transfers the regulatory signals conveyed by Yap8 to the core transcriptional machinery, which culminates with TBP occupancy, ACR2 upregulation and cell adaptation to arsenate stress. Additional co-factors are required for the transcriptional activation of ACR2 by Yap8, particularly the nucleosome remodeling activity of SWI/SNF and SAGA complexes. Copyright © 2017. Published by Elsevier B.V.

75 FR 7634 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the Subcommittee on Power Uprates...

Science.gov (United States)

2010-02-22

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the Subcommittee on Power Uprates; Notice of Meeting The ACRS Subcommittee on Power Uprates will hold a meeting on... arrangements can be made. Thirty-five hard copies of each presentation or handout should be provided to the DFO...

Computational Study of Correlated Domain Motions in the AcrB Efflux Transporter

Directory of Open Access Journals (Sweden)

Robert Schulz

2015-01-01

Full Text Available As active part of the major efflux system in E. coli bacteria, AcrB is responsible for the uptake and pumping of toxic substrates from the periplasm toward the extracellular space. In combination with the channel protein TolC and membrane fusion protein AcrA, this efflux pump is able to help the bacterium to survive different kinds of noxious compounds. With the present study we intend to enhance the understanding of the interactions between the domains and monomers, for example, the transduction of mechanical energy from the transmembrane domain into the porter domain, correlated motions of different subdomains within monomers, and cooperative effects between monomers. To this end, targeted molecular dynamics simulations have been employed either steering the whole protein complex or specific parts thereof. By forcing only parts of the complex towards specific conformational states, the risk for transient artificial conformations during the simulations is reduced. Distinct cooperative effects between the monomers in AcrB have been observed. Possible allosteric couplings have been identified providing microscopic insights that might be exploited to design more efficient inhibitors of efflux systems.

Subchannel flow analysis in Candu and ACR pressure tubes with radial and axial diameter variation

Energy Technology Data Exchange (ETDEWEB)

Catana, A.; Prodea, L. [RAAN, Institute for Nuclear Research, Arges (Romania); Danila, N.; Prisecaru, I.; Dupleac, D. [Bucharest Univ. Politehnica(Romania)

2007-07-01

The Candu (Canada Deuterium Uranium) and ACR (Advanced Candu Reactor) are pressure tubes (PT) heavy water moderated reactors. Candu are heavy water and ACR are light water cooled reactors. The pressure tube is filled with 12 bundles, each consisting of 37 respectively 43 fuel rods. One Candu reactor is in operation at Cernavoda, Romania since 1996. ACR is a proposed advanced Candu. PT diameter variation has a significant impact on the thermal-hydraulic parameters. Almost all thermal-hydraulic parameters change, but some of them have a greater significance. In this work we have considered a set of radial and axial PT diameter variations both for Candu-600 and ACR-700 reactors using various types of fuel bundles. We can conclude the following: 1) some thermal-hydraulic parameters are significantly influenced: critical heat flux (CHF), pressure drop, or void fraction; 2) the most significant parameter CHF is worsening which reduces the safety margin; 3) some fuel types present a better thermal-hydraulic behavior; and 4) fuel bundles with fresh fuel or low burnup have a worse thermal-hydraulic behaviour than those at average burn-up.

Subchannel flow analysis in Candu and ACR pressure tubes with radial and axial diameter variation

International Nuclear Information System (INIS)

Catana, A.; Prodea, L.; Danila, N.; Prisecaru, I.; Dupleac, D.

2007-01-01

The Candu (Canada Deuterium Uranium) and ACR (Advanced Candu Reactor) are pressure tubes (PT) heavy water moderated reactors. Candu are heavy water and ACR are light water cooled reactors. The pressure tube is filled with 12 bundles, each consisting of 37 respectively 43 fuel rods. One Candu reactor is in operation at Cernavoda, Romania since 1996. ACR is a proposed advanced Candu. PT diameter variation has a significant impact on the thermal-hydraulic parameters. Almost all thermal-hydraulic parameters change, but some of them have a greater significance. In this work we have considered a set of radial and axial PT diameter variations both for Candu-600 and ACR-700 reactors using various types of fuel bundles. We can conclude the following: 1) some thermal-hydraulic parameters are significantly influenced: critical heat flux (CHF), pressure drop, or void fraction; 2) the most significant parameter CHF is worsening which reduces the safety margin; 3) some fuel types present a better thermal-hydraulic behavior; and 4) fuel bundles with fresh fuel or low burnup have a worse thermal-hydraulic behaviour than those at average burn-up

Spatial and spatio-temporal analysis of malaria in the state of Acre, western Amazon, Brazil

Directory of Open Access Journals (Sweden)

Leonardo Augusto Kohara Melchior

2016-11-01

Full Text Available Since 2005, the State of Acre, western Amazon, Brazil, has reported the highest annual parasite incidence (API of malaria among the Brazilian states. This study examines malaria incidence in Acre using spatial and spatio-temporal analysis based on an ecological time series study analyzing malaria cases and deaths for the time period 1992- 2014 and using secondary data. API indexes were calculated by age, sex, parasite species, ratio of Plasmodium vivax to P. falciparum malaria, malaria mortality rate and case fatality rate. SaTScan was used to detect spatial and spatio-temporal clusters of malaria cases and data were represented in the form of choropleth maps. A high-risk cluster of malaria was detected in Vale do Juruá and three low-risk clusters in Vale do Acre for both parasite species. Those younger than 19 years of age and females showed a high incidence of malaria in Vale do Juruá, but working-age males were the most affected in Vale do Acre. The malaria mortality rate showed a decreasing trend across the state, while the case fatality rate increased only in the micro-region of Rio Branco during the study period. We conclude that malaria is a focal disease in Acre showing different spatial and spatio-temporal patterns of cases and deaths that vary by age, sex, and parasite species. Malaria incidence is thought to be influenced by factors related to regional characteristics; therefore, appropriate disease and vector control strategies must be implemented at each locality.

Expression of the marA, soxS, acrB and ramA genes related to the AcrAB/TolC efflux pump in Salmonella entérica strains with and without quinolone resistance-determining regions gyrA gene mutations

Directory of Open Access Journals (Sweden)

Rafaela Gomes Ferrari

2013-04-01

Full Text Available Several studies have been conducted in recent years to elucidate the structure, function and significance of AcrB, MarA, SoxS and RamA in Salmonella enterica. In this study, the relative quantification of acrB, soxS, marA and ramA genes expression was evaluated in 14 strains of S. enterica, with or without accompanying mutations in the quinolone resistance-determining regions of the gyrA gene, that were exposed to ciprofloxacin during the exponential growth phase. The presence of ciprofloxacin during the log phase of bacterial growth activated the genes marA, soxS, ramA and acrB in all S. enterica strains analyzed in this study. The highest expression levels for acrB were observed in strains with gyrA mutation, and marA showed the highest expression in the strains without mutation. Considering only the strains with ciprofloxacin minimum inhibitory concentration values 0.125 [1]g/mL (low susceptibility, with and without mutations in gyrA, the most expressed gene was marA. In this study, we observed that strains resistant to nalidixic acid may express genes associated with the efflux pump and the expression of the AcrAB-TolC pump genes seems to occur independently of mutations in gyrA.

Expression of the marA, soxS, acrB and ramA genes related to the AcrAB/TolC efflux pump in Salmonella entérica strains with and without quinolone resistance-determining regions gyrA gene mutations

Directory of Open Access Journals (Sweden)

Rafaela Gomes Ferrari

Full Text Available Several studies have been conducted in recent years to elucidate the structure, function and significance of AcrB, MarA, SoxS and RamA in Salmonella enterica. In this study, the relative quantification of acrB, soxS, marA and ramA genes expression was evaluated in 14 strains of S. enterica, with or without accompanying mutations in the quinolone resistance-determining regions of the gyrA gene, that were exposed to ciprofloxacin during the exponential growth phase. The presence of ciprofloxacin during the log phase of bacterial growth activated the genes marA, soxS, ramA and acrB in all S. enterica strains analyzed in this study. The highest expression levels for acrB were observed in strains with gyrA mutation, and marA showed the highest expression in the strains without mutation. Considering only the strains with ciprofloxacin minimum inhibitory concentration values 0.125 [1]g/mL (low susceptibility, with and without mutations in gyrA, the most expressed gene was marA. In this study, we observed that strains resistant to nalidixic acid may express genes associated with the efflux pump and the expression of the AcrAB-TolC pump genes seems to occur independently of mutations in gyrA.

Contribution of AcrAB-ToIC to multidrug resistance in an Escherichia coli sequence type 131 isolate

NARCIS (Netherlands)

Schuster, Sabine; Vavra, Martina; Schweigger, Tobias M.; Rossen, John W. A.; Matsumura, Yasufumi; Kern, Winfried V.

Drug efflux by resistance-nodulation-cell division (RND)-type transporters, such as AcrAB-ToIC of Escherichia can, is an important resistance mechanism in Gram-negative bacteria; however, its contribution to multidrug resistance (MDR) in clinical isolates is poorly defined. We inactivated acrB of a

Modeling Human Error Mechanism for Soft Control in Advanced Control Rooms (ACRs)

Energy Technology Data Exchange (ETDEWEB)

Aljneibi, Hanan Salah Ali [Khalifa Univ., Abu Dhabi (United Arab Emirates); Ha, Jun Su; Kang, Seongkeun; Seong, Poong Hyun [KAIST, Daejeon (Korea, Republic of)

2015-10-15

To achieve the switch from conventional analog-based design to digital design in ACRs, a large number of manual operating controls and switches have to be replaced by a few common multi-function devices which is called soft control system. The soft controls in APR-1400 ACRs are classified into safety-grade and non-safety-grade soft controls; each was designed using different and independent input devices in ACRs. The operations using soft controls require operators to perform new tasks which were not necessary in conventional controls such as navigating computerized displays to monitor plant information and control devices. These kinds of computerized displays and soft controls may make operations more convenient but they might cause new types of human error. In this study the human error mechanism during the soft controls is studied and modeled to be used for analysis and enhancement of human performance (or human errors) during NPP operation. The developed model would contribute to a lot of applications to improve human performance (or reduce human errors), HMI designs, and operators' training program in ACRs. The developed model of human error mechanism for the soft control is based on assumptions that a human operator has certain amount of capacity in cognitive resources and if resources required by operating tasks are greater than resources invested by the operator, human error (or poor human performance) is likely to occur (especially in 'slip'); good HMI (Human-machine Interface) design decreases the required resources; operator's skillfulness decreases the required resources; and high vigilance increases the invested resources. In this study the human error mechanism during the soft controls is studied and modeled to be used for analysis and enhancement of human performance (or reduction of human errors) during NPP operation.

Modeling Human Error Mechanism for Soft Control in Advanced Control Rooms (ACRs)

International Nuclear Information System (INIS)

Aljneibi, Hanan Salah Ali; Ha, Jun Su; Kang, Seongkeun; Seong, Poong Hyun

2015-01-01

To achieve the switch from conventional analog-based design to digital design in ACRs, a large number of manual operating controls and switches have to be replaced by a few common multi-function devices which is called soft control system. The soft controls in APR-1400 ACRs are classified into safety-grade and non-safety-grade soft controls; each was designed using different and independent input devices in ACRs. The operations using soft controls require operators to perform new tasks which were not necessary in conventional controls such as navigating computerized displays to monitor plant information and control devices. These kinds of computerized displays and soft controls may make operations more convenient but they might cause new types of human error. In this study the human error mechanism during the soft controls is studied and modeled to be used for analysis and enhancement of human performance (or human errors) during NPP operation. The developed model would contribute to a lot of applications to improve human performance (or reduce human errors), HMI designs, and operators' training program in ACRs. The developed model of human error mechanism for the soft control is based on assumptions that a human operator has certain amount of capacity in cognitive resources and if resources required by operating tasks are greater than resources invested by the operator, human error (or poor human performance) is likely to occur (especially in 'slip'); good HMI (Human-machine Interface) design decreases the required resources; operator's skillfulness decreases the required resources; and high vigilance increases the invested resources. In this study the human error mechanism during the soft controls is studied and modeled to be used for analysis and enhancement of human performance (or reduction of human errors) during NPP operation

Genetic diversity of "Pimenta Longa" genotypes (Piper spp., Piperaceae) of the Embrapa Acre germplasm collection

OpenAIRE

Wadt, Lúcia Helena de Oliveira; Ehringhaus, Christiane; Kageyama, Paulo Yoshio

2004-01-01

The commonly known Pimenta longa is a commercially valuable natural resource found wild in Acre, Brazil. Specifically, three Piperaceae species with contested taxonomic status were studied, Piper hispidinervum, Piper aduncum, and Piper hispidum, to assesses the inter- and intra-specific genetic relationship of 49 Piper genotypes kept in the Pimenta longa germplasm collection at Embrapa Acre, using sixty six Random Amplified Polymorphic DNA (RAPD) markers. The DNA polymorphism level detected w...

Mitigation and monitoring plan for impacted wetlands at the Gunnison UMTRA Project site, Gunnison, Colorado

International Nuclear Information System (INIS)

1992-06-01

The U.S Department of Energy (DOE) administers the Uranium Mill Tailings Remedial Action (UMTRA) Project. The UMTRA Project is the result of the Uranium Mill Tailings Radiation Control Act(UMTRA) which was passed in response to the public's concern over the potential public health hazards related to uranium mill tailings and associated contaminated material at abandoned or otherwise uncontrolled inactive processing sites throughout the United States. The Gunnison, Colorado abandoned uranium mill site is one of the sites slated for cleanup by the DOE under authority of UMTRA. The contaminated material at this site will be transported to a disposal site on US Bureau of Land Management (BLM) land east of Gunnison. Remedial action activities will temporarily disturb 0.8 acre and permanently eliminate 5.1 acres of wetlands. This report describes the proposed mitigation plan for the 5.9 acres of impacted wetlands. In conjunction with the mitigation of the permanently impacted wetlands through the enhancement of wetland and adjacent riparian areas, impacts to wildlife as a result of this project will also be mitigated. However, wildlife mitigation is not the focus of this document and is covered in relevant BLM permits for this project. This plan proposes the enhancement of a 3:1 ratio of impacted wetlands in accordance with US Environmental Protection Agency guidelines, plus the enhancement of riparian areas for wildlife mitigation. Included in this mitigation plan is a monitoring plan to ensure that the proposed measures are working and being maintained

The introduction of dengue follows transportation infrastructure changes in the state of Acre, Brazil: A network-based analysis.

Science.gov (United States)

Lana, Raquel Martins; Gomes, Marcelo Ferreira da Costa; Lima, Tiago França Melo de; Honório, Nildimar Alves; Codeço, Cláudia Torres

2017-11-01

Human mobility, presence and passive transportation of Aedes aegypti mosquito, and environmental characteristics are a group of factors which contribute to the success of dengue spread and establishment. To understand this process, we assess data from dengue national and municipal basins regarding population and demographics, transportation network, human mobility, and Ae. aegypti monitoring for the Brazilian state of Acre since the first recorded dengue case in the year 2000 to the year 2015. During this period, several changes in Acre's transport infrastructure and urbanization have been started. To reconstruct the process of dengue introduction in Acre, we propose an analytic framework based on concepts used in malaria literature, namely vulnerability and receptivity, to inform risk assessments in dengue-free regions as well as network theory concepts for disease invasion and propagation. We calculate the probability of dengue importation to Acre from other Brazilian states, the evolution of dengue spread between Acrean municipalities and dengue establishment in the state. Our findings suggest that the landscape changes associated with human mobility have created favorable conditions for the establishment of dengue virus transmission in Acre. The revitalization of its major roads, as well as the increased accessibility by air to and within the state, have increased dengue vulnerability. Unplanned urbanization and population growth, as observed in Acre during the period of study, contribute to ideal conditions for Ae. aegypti mosquito establishment, increase the difficulty in mosquito control and consequently its local receptivity.

The Japanese version of the modified ACR preliminary diagnostic criteria for fibromyalgia and the fibromyalgia symptom scale: reliability and validity.

Science.gov (United States)

Usui, Chie; Hatta, Kotaro; Aratani, Satoko; Yagishita, Naoko; Nishioka, Kenya; Kanazawa, Teruhisa; Itoh, Kenji; Yamano, Yoshihisa; Nakamura, Hiroyuki; Nakajima, Toshihiro; Nishioka, Kusuki

2013-09-01

The aim of this study is to investigate the reliability and validity of the Japanese version of the modified American College of Rheumatology (ACR) Preliminary Diagnostic Criteria for Fibromyalgia (mACR 2010-J) and the Fibromyalgia Symptom Scale (mFS-J). According to the ACR 1990 classification criteria, patients with chronic pain were divided into the fibromyalgia group and nonfibromyalgia group (rheumatoid arthritis and osteoarthritis). Patients in both groups were assessed using mACR 2010-J and mFS-J. 294 of 462 (64 %) patients in the fibromyalgia group met mACR 2010-J, whereas 4 % (9/231) of the nonfibromyalgia group did, with sensitivity of 64 %, specificity of 96 %, positive predictive value of 97 %, negative predictive value of 56 %, and positive likelihood ratio of 16.3. Mean total scores on mFS-J significantly differentiated the fibromyalgia from the nonfibromyalgia group. According to the value of the Youden index, the best cutoff score for the mFS-J was 9/10. Our findings indicate that mACR 2010-J as a positive test and mFS-J as a quantification scale might be suitable for assessing fibromyalgia among Japanese chronic pain populations.

Nota sobre culicídeos (Diptera: Culicidae da bacia do rio Purus, Acre, Amazônia (Brasil Note on the culicidae (Diptera: Culicidae of the River Purus Basin, Acre, Amazonian, Brazil

Directory of Open Access Journals (Sweden)

Delsio Natal

1992-04-01

Full Text Available Foram feitas coletas de mosquito (Diptera: Culicidae na área do projeto de Colonização Pedro Peixoto, no Estado do Acre, Brasil. Obteve-se um total de 4.588 exemplares pertencentes a 53 espécies ou grupos. Salienta-se a ocorrência de Anopheles (Nyssorhynchus oswaldoi.Mosquito (Diptera: Culicidae collections were made on the Pedro Peixoto Colonization Project in the State of Acre, Brazil. Four thousand, five hundred and eighty-eight (4,588 specimens were collected and fifty-three (53 species or group recognised. The occurrence of Anopheles (Nyssorhynchus oswaldoi is given special emphasis.

The concept of incomplete fibromyalgia syndrome: comparison of incomplete fibromyalgia syndrome with fibromyalgia syndrome by 1990 ACR classification criteria and its implications for newer criteria and clinical practice.

Science.gov (United States)

Yunus, Muhammad B; Aldag, Jean C

2012-03-01

The 1990 American College of Rheumatology (ACR) classification criteria for fibromyalgia/fibromyalgia syndrome (FMS) has 2 components: (a) widespread pain (WSP) and (b) presence of 11 or more tender points (TP) among possible 18 sites. Some clinic patients fulfill 1 component but not the other. We have considered these patients to have incomplete FMS (IFMS). The purpose of this study was to examine the clinical and psychological differences between IFMS and FMS (by 1990 ACR criteria) because such comparison may be helpful to diagnose patients in the clinic. Six hundred consecutive patients referred to our rheumatology clinic with a diagnosis of FMS were examined by a standard protocol to determine whether they fulfilled the 1990 criteria for FMS. Both IFMS and FMS groups were compared in demographic, clinical, and psychological variables using appropriate statistical methods. One hundred twelve (18.7%) patients did not satisfy the 1990 ACR criteria and were classified as IFMS. Symptoms in IFMS and FMS were similar, generally with less frequent and less severe symptoms in the IFMS group. In IFMS, no significant difference was found among the WSP and TP component subgroups. Both TP and WSP were correlated with important features of FMS. Fulfillment of the ACR 1990 criteria is not necessary for a diagnosis of FMS in the clinic. For diagnosis and management of FMS in the clinical setting, IFMS patients, along with consideration of the total clinical picture, may be considered to have FMS, albeit generally mild.

ACR appropriateness criteria blunt chest trauma.

Science.gov (United States)

Chung, Jonathan H; Cox, Christian W; Mohammed, Tan-Lucien H; Kirsch, Jacobo; Brown, Kathleen; Dyer, Debra Sue; Ginsburg, Mark E; Heitkamp, Darel E; Kanne, Jeffrey P; Kazerooni, Ella A; Ketai, Loren H; Ravenel, James G; Saleh, Anthony G; Shah, Rakesh D; Steiner, Robert M; Suh, Robert D

2014-04-01

Imaging is paramount in the setting of blunt trauma and is now the standard of care at any trauma center. Although anteroposterior radiography has inherent limitations, the ability to acquire a radiograph in the trauma bay with little interruption in clinical survey, monitoring, and treatment, as well as radiography's accepted role in screening for traumatic aortic injury, supports the routine use of chest radiography. Chest CT or CT angiography is the gold-standard routine imaging modality for detecting thoracic injuries caused by blunt trauma. There is disagreement on whether routine chest CT is necessary in all patients with histories of blunt trauma. Ultimately, the frequency and timing of CT chest imaging should be site specific and should depend on the local resources of the trauma center as well as patient status. Ultrasound may be beneficial in the detection of pneumothorax, hemothorax, and pericardial hemorrhage; transesophageal echocardiography is a first-line imaging tool in the setting of suspected cardiac injury. In the blunt trauma setting, MRI and nuclear medicine likely play no role in the acute setting, although these modalities may be helpful as problem-solving tools after initial assessment. The ACR Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed every 2 years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer-reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel. In those instances in which evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatment. Copyright © 2014 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Site 300 City Water Master Plan

Energy Technology Data Exchange (ETDEWEB)

Shaw, Jeff [Stantec Consulting Services Inc., Irvine, CA (United States)

2017-03-13

Lawrence Livermore National Laboratory (LLNL), a scientific research facility, operates an experimental test site known as Site 300. The site is located in a remote area of southeastern Alameda County, California, and consists of about 100 facilities spread across 7,000-acres. The Site 300 water system includes groundwater wells and a system of storage tanks, booster pumps, and underground piping to distribute water to buildings and significant areas throughout the site. Site 300, which is classified as a non-transient non-community (NTNC) water system, serves approximately 110 employees through 109 service connections. The distribution system includes approximately 76,500-feet of water mains varying from 4- to 10-inches in diameter, mostly asbestos cement (AC) pipe, and eleven water storage tanks. The water system is divided into four pressure zones fed by three booster pump stations to tanks in each zone.

Involvement of the Acr3 and DctA anti-porters in arsenite oxidation in Agrobacterium tumefaciens 5A.

Science.gov (United States)

Kang, Yoon-Suk; Shi, Zunji; Bothner, Brian; Wang, Gejiao; McDermott, Timothy R

2015-06-01

Microbial arsenite (AsIII) oxidation forms a critical piece of the arsenic cycle in nature, though our understanding of how and why microorganisms oxidize AsIII remains rudimentary. Our model organism Agrobacterium tumefaciens 5A contains two distinct ars operons (ars1 and ars2) that are similar in their coding region content. The ars1 operon is located nearby the aio operon that is essential for AsIII oxidation. The AsIII/H(+) anti-porters encoded by acr3-1 and acr3-2 are required for maximal AsIII and antimonite (SbIII) resistance, but acr3-1 (negatively regulated by ArsR-1) appears more active in this regard and also required for AsIII oxidation and expression of aioBA. A malate-phosphate anti-porter DctA is regulated by RpoN and AsIII, and is required for normal growth with malate as a sole carbon source. Qualitatively, a ΔdctA mutant was normal for AsIII oxidation and AsIII/SbIII resistance at metalloid concentrations inhibitory to the Δacr3-1 mutant; however, aioBA induction kinetics was significantly phase-shift delayed. Acr3 involvement in AsIII/SbIII resistance is reasonably well understood, but the role of Acr3 and DctA anti-porters in AsIII oxidation and its regulation is unexpected, and suggests that controlled AsIII trafficking across the cytoplasmic membrane is important to a process understood to occur in the periplasm. © 2014 Society for Applied Microbiology and John Wiley & Sons Ltd.

First report of Rhodnius stali (Hemiptera, Reduviidae, Triatominae in the State of Acre and in the Brazilian Amazon

Directory of Open Access Journals (Sweden)

Dionatas Ulises de Oliveira Meneguetti

2016-06-01

Full Text Available Abstract: INTRODUCTION: This paper reports, for the first time, the presence of Rhodnius stali in the state of Acre and in the Brazilian Amazon. METHODS: Specimens of R. stali were collected by the Federal University of Acre in Rio Branco. RESULTS: The number of Triatominae species in the State of Acre increased from five to six. This was also the first report of R. stali in the Brazilian Amazon. CONCLUSIONS: The occurrence of R. stali is worrisome, since this species has been found naturally infected by Trypanosoma cruzi and there has been evidence of its domiciliation capabilities.

InfAcrOnt: calculating cross-ontology term similarities using information flow by a random walk.

Science.gov (United States)

Cheng, Liang; Jiang, Yue; Ju, Hong; Sun, Jie; Peng, Jiajie; Zhou, Meng; Hu, Yang

2018-01-19

Since the establishment of the first biomedical ontology Gene Ontology (GO), the number of biomedical ontology has increased dramatically. Nowadays over 300 ontologies have been built including extensively used Disease Ontology (DO) and Human Phenotype Ontology (HPO). Because of the advantage of identifying novel relationships between terms, calculating similarity between ontology terms is one of the major tasks in this research area. Though similarities between terms within each ontology have been studied with in silico methods, term similarities across different ontologies were not investigated as deeply. The latest method took advantage of gene functional interaction network (GFIN) to explore such inter-ontology similarities of terms. However, it only used gene interactions and failed to make full use of the connectivity among gene nodes of the network. In addition, all existent methods are particularly designed for GO and their performances on the extended ontology community remain unknown. We proposed a method InfAcrOnt to infer similarities between terms across ontologies utilizing the entire GFIN. InfAcrOnt builds a term-gene-gene network which comprised ontology annotations and GFIN, and acquires similarities between terms across ontologies through modeling the information flow within the network by random walk. In our benchmark experiments on sub-ontologies of GO, InfAcrOnt achieves a high average area under the receiver operating characteristic curve (AUC) (0.9322 and 0.9309) and low standard deviations (1.8746e-6 and 3.0977e-6) in both human and yeast benchmark datasets exhibiting superior performance. Meanwhile, comparisons of InfAcrOnt results and prior knowledge on pair-wise DO-HPO terms and pair-wise DO-GO terms show high correlations. The experiment results show that InfAcrOnt significantly improves the performance of inferring similarities between terms across ontologies in benchmark set.

Morphometric traits in arbor-acres broiler chicken ( Gallus gallus )fed ...

African Journals Online (AJOL)

Fifty sixth day morphometric and body weight measurements were taken on one hundred and forty eight Arbor Acres broiler chickens reared under the Deep Litter system in the guinea savana Zone of Nigeria. This study aimed to determine the effects of substituting treated and untreated Cocoa Bean Shell (CBS) at 50 and ...

Gnome-Coach, New Mexico Site Fact Sheet

International Nuclear Information System (INIS)

2009-01-01

The Gnome-Coach Site is located in southern Eddy County, New Mexico, 11 miles east of the Pecos River and 25 miles southeast of the city of Carlsbad. The site is approximately 680 acres. The land is currently withdrawn from all forms of disposition under the public land laws, including U.S. mining laws and leasing under mineral leasing laws. On December 10, 1961, a 3-kiloton-yield nuclear device was detonated at a depth of 1,183 feet below ground surface in a thick, bedded salt deposit within the Salado Formation.

A survey of the wetlands and floodplains of the borrow area and wetland/shorebird complex for the remedial action at the chemical plant area of the Weldon Spring Site

Energy Technology Data Exchange (ETDEWEB)

Van Lonkhuyzen, R.; Yin, S.; Hlohowskyj, I.

1995-02-01

The US Department of Energy is conducting cleanup operations at the Weldon Spring site, St. Charles, Missouri, that will include development of a 77-ha (191-acre) soil borrow area. Eight wetlands, including riverine and palustrine emergent wetland types and totaling 0.9 ha (2.2 acres), will be eliminated during excavation of the borrow area. A 23-ha (57-acre) wetland/shorebird complex will be created at the Busch Conservation Area. The complex will include 2 ha (5 acres) of palustrine emergent wetland as mitigation for wetland losses in the borrow area.

Weldon Spring storage site environmental-monitoring report for 1979 and 1980

International Nuclear Information System (INIS)

Weidner, R.B.; Boback, M.W.

1982-01-01

The US Department of Energy (DOE) Weldon Spring Site consists of two separate radioactive waste storage properties: a 52-acre site which is a remnant of the Weldon Spring Feed Materials Plant; and a 9-acre abandoned rock quarry. The larger property has four pits which contain settled sludge from uranium and thorium processing operations. At the quarry, part of the excavation contains contaminated building rubble, scrap, and various residues. During 1979 and 1980 these storage locations were managed by NLO, Inc., contract operator of the DOE Feed Materials Production Center. Air and water samples were collected to provide information about the transfer of radionuclides in the offsite environment. Monitoring results show that uranium and radium concentrations in offsite surface and well water were within DOE Guide values for uncontrolled areas. At offsite locations, radon-222 concentrations in air were well within the Guide value

Environmental assessment of remedial action at the Mexican Hat uranium mill tailings site, Mexican Hat, Utah

International Nuclear Information System (INIS)

1987-10-01

This document assesses the environmental impacts of the proposed remedial action at the Mexican Hat uranium mill tailings site located on the Navajo Reservation in southern Utah. The site covers 235 acres and contains 69 acres of tailings and several of the original mill structures. Remedial action must be performed in accordance with standards and with the concurrence of the US Nuclear Regulatory Commission and the Navajo Nation. The proposed action is to stabilize the tailings within the present tailings site by consolidating the tailings and associated contaminated soils into a recontoured pile. A radon barrier of compacted earth would be constructed over the pile, and various erosion control measures would be taken to assure the long-term stability of the pile. The no action alternative is also assessed in this document. 240 refs., 12 figs., 20 tabs

Remedial action plan and site design for stabilization of the inactive uranium mill tailings sites at Slick Rock, Colorado

International Nuclear Information System (INIS)

1993-07-01

The Slick Rock uranium mill tailings sites are located near the small town of Slick Rock, in San Miguel County, Colorado. There are two designated UMTRA sites at Slick Rock, the Union Carbide (UC) site and the North Continent (NC) site. Both sites are adjacent to the Dolores River. The UC site is approximately 1 mile (mi) [2 kilometers (km)] downstream of the NC site. Contaminated materials cover an estimated 55 acres (ac) [22 hectares (ha)] at the UC site and 12 ac (4.9 ha) at the NC site. The sites contain former mill building concrete foundations, tailings piles, demolition debris, and areas contaminated by windblown and waterborne radioactive materials. The total estimated volume of contaminated materials is approximately 620, 000 cubic yards (yd 3 ) [470,000 cubic meters (m 3 )]. In addition to the contamination at the two processing site areas, four vicinity properties were contaminated. Contamination associated with the UC and NC sites has leached into groundwater

Validity and reliability problems with patient global as a component of the ACR/EULAR remission criteria as used in clinical practice.

Science.gov (United States)

Masri, Karim R; Shaver, Timothy S; Shahouri, Shadi H; Wang, Shirley; Anderson, James D; Busch, Ruth E; Michaud, Kaleb; Mikuls, Ted R; Caplan, Liron; Wolfe, Frederick

2012-06-01

To investigate what factors influence patient global health assessment (PtGlobal), and how those factors and the reliability of PtGlobal affect the rate, reliability, and validity of recently published American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) rheumatoid arthritis (RA) remission criteria when used in clinical practice. We examined consecutive patients with RA in clinical practice and identified 77 who met ACR/EULAR joint criteria for remission (≤ 1 swollen joint and ≤ 1 tender joint). We evaluated factors associated with a PtGlobal > 1, because a PtGlobal ≤ 1 defined ACR/EULAR remission in this group of patients who had already met ACR/EULAR joint criteria. Of the 77 patients examined, only 17 (22.1%) had PtGlobal ≤ 1 and thus fully satisfied ACR/EULAR criteria. A large proportion of patients not in remission by ACR/EULAR criteria had high PtGlobal related to noninflammatory issues, including low back pain, fatigue, and functional limitations, and a number of patients clustered in the range of PtGlobal > 1 and ≤ 2. However, the minimal detectable difference for PtGlobal was 2.3. In addition, compared with a PtGlobal severity score, a PtGlobal activity score was 3.3% less likely to be abnormal (> 1). Noninflammatory factors contribute to the level of PtGlobal and result in the exclusion of many patients who would otherwise be in "true" remission according to the ACR/EULAR definition. Reliability problems associated with PtGlobal can also result in misclassification, and may explain the observation of low longterm remission rates in RA. As currently constituted, the use of the ACR/EULAR remission criteria in clinical practice appears to be problematic.

SUBSURFACE DESIGN SUPPORT LOW THERMAL LOAD REPOSITORY (25 MTU/ACRE)

International Nuclear Information System (INIS)

T.M. Lahnalampi

1999-01-01

The objective of this document is to present a comparison between the Viability Assessment Design Layout and a 25 MTU/acre conceptual repository design. The scope of this analysis is comparing the linear dimensions and the quantities of the major design elements, for example, emplacement drifts, perimeter mains, exhaust mains, performance confirmation drifts, connecting ramps and vertical development

Streamlined RI/FS planning for the groundwater operable unit at the Weldon Spring Site

International Nuclear Information System (INIS)

Picel, M.H.; Durham, L.A.; Blunt, D.L.; Hartmann, H.M.

1995-01-01

The U.S. Department of Energy (DOE) is conducting cleanup activities at the chemical plant area of the Weldon Spring Site located in St. Charles County, Missouri, about 48 km (30 mi) west of St. Louis and 22 km (14 mi) southwest of the City of St. Charles. The 88-ha (217-acre) chemical plant area is chemically and radioactively contaminated as a result of uranium processing activities conducted by the U.S. Atomic Energy Commission during the 1950s and 1960s. The Army also used the chemical plant area for the production of explosives in the 1940s. The Weldon Spring Site chemical plant area was listed on the National Priorities List (NPL) in 1989. Adjacent to the chemical plant area is another NPL site known as the Weldon Spring Ordnance Works. The ordnance works area is a former explosive production facility that manufactured trinitrotoluene (TNT) and dinitrotoluene (DNT) during World War II. The ordnance works area covers 7,000 ha (17,232 acres); cleanup of this site is managed by the U.S. Army Corps of Engineers (CE)

Desempenho de cultivares de alface no Estado do Acre Performance of lettuce cultivars in the State of Acre, Brazil

Directory of Open Access Journals (Sweden)

Francisco J. da S. Lédo

2000-11-01

Full Text Available Devido às condições ambientais verificadas no estado do Acre, caracterizado pela ocorrência de temperaturas elevadas e alta precipitação, as cultivares tradicionalmente utilizadas pelos produtores apresentam baixo rendimento e qualidade. O objetivo do presente trabalho foi avaliar o comportamento das novas cultivares de alface disponíveis no mercado, em termos de características agronômicas e rendimento, nas condições edafoclimáticas de Rio Branco, Acre. Para isso foram realizados dois ensaios no campo experimental da Embrapa Acre, em um solo do tipo Argissolo Vermelho-Escuro, textura argilosa. O primeiro de maio a julho de 1996 (período seco e o segundo de dezembro de 1996 a fevereiro de 1997 (período chuvoso. Foram avaliadas as cultivares Babá de Verão, Brisa, Carolina AG-576, Elisa, Lucy Brown, Marisa AG-216, Piracicaba 65, Regina 71, Tainá, Simpson, Vanessa e Verônica, sendo que 'Regina 71' e 'Elisa' foram incluídas apenas no ensaio do período seco. O delineamento experimental foi o de blocos casualizados, com três repetições. No período seco, as cultivares Simpson, Lucy Brown e Regina 71 apresentaram os maiores pesos médios (373; 362 e 341 g, respectivamente e produções comerciais de 49,8; 48,3 e 45,5 t/ha, respectivamente. Em geral, as cultivares dos tipos lisa sem cabeça e lisa com cabeça apresentaram maior índice de ataque de nematóide (Meloidogyne javanica quando comparadas às do tipo crespa. No ensaio realizado no período chuvoso, as cultivares Marisa AG-216, Verônica, Lucy Brown, Brisa, Tainá e Piracicaba-65 apresentaram os maiores pesos médios e produções comerciais. Entretanto, as médias obtidas foram bem inferiores às verificadas no ensaio do período seco, variando de 164 a 198 g para o peso médio, e 21,9 a 25,9 t/ha para produção comercial. Dentre as cultivares avaliadas no período seco, Regina 71 (lisa, sem cabeça e Carolina AG-576 (lisa, com cabeça destacaram-se entre as do tipo

Superfund Record of Decision (EPA Region 2): Ramapo Landfill Site, Rockland County, NY. (First remedial action), March 1992. Final report

International Nuclear Information System (INIS)

1992-01-01

The 60-acre former landfill site is located on a 96-acre tract in the Town of Ramapo, Rockland County, New York, about 35 miles northwest of New York City. Utility corridors lie on three sides of the site, including high-voltage power transmission lines. The site is currently being used as a compaction and transfer facility by the Town of Ramapo. Trash and debris are weighed at a weigh station/guardhouse, compacted at a baler facility in the northeastern corner of the site, and transferred to the Al Turi Landfill in Goshen, New York. The ROD represents the entire remedial action for the site by controlling source of contamination and the generation of leachate, and treatment of contaminated ground water. The primary contaminants of concern affecting soil, ground water, and surface water are VOCs, including benzene; other organics; and metals, including arsenic, chromium, and lead. The selected remedial action for the site is included

Environmental assessment of remedial action at the Lowman Uranium Mill Tailings Site near Lowman, Idaho

International Nuclear Information System (INIS)

1991-01-01

This document assesses the environmental impacts of stabilization on site of the contaminated materials at the Lowman uranium mill tailings site. The Lowman site is 0.5 road mile northeast of the unincorporated village of Lowman, Idaho, and 73 road miles from Boise, Idaho. The Lowman site consists of piles of radioactive sands, an ore storage area, abandoned mill buildings, and windblown/waterborne contaminated areas. A total of 29.5 acres of land are contaminated and most of this land occurs within the 35-acre designated site boundary. The proposed action is to stabilize the tailings and other contaminated materials on the site. A radon barrier would be constructed over the consolidated residual radioactive materials and various erosion control measures would be implemented to ensure the long-term stability of the disposal cell. Radioactive constituents and other hazardous constituents were not detected in the groundwater beneath the Lowman site. The groundwater beneath the disposal cell would not become contaminated during or after remedial action so the maximum concentration limits or background concentrations for the contaminants listed in the draft EPA groundwater protection standards would be met at the point of compliance. No significant impacts were identified as a result of the proposed remedial action at the Lowman site

Assessment of diffusion tensor image quality across sites and vendors using the American College of Radiology head phantom.

Science.gov (United States)

Wang, Zhiyue J; Seo, Youngseob; Babcock, Evelyn; Huang, Hao; Bluml, Stefan; Wisnowski, Jessica; Holshouser, Barbara; Panigrahy, Ashok; Shaw, Dennis W W; Altman, Nolan; McColl, Roderick W; Rollins, Nancy K

2016-05-08

The purpose of this study was to explore the feasibility of assessing quality of diffusion tensor imaging (DTI) from multiple sites and vendors using American College of Radiology (ACR) phantom. Participating sites (Siemens (n = 2), GE (n= 2), and Philips (n = 4)) reached consensus on parameters for DTI and used the widely available ACR phantom. Tensor data were processed at one site. B0 and eddy current distortions were assessed using grid line displacement on phantom Slice 5; signal-to-noise ratio (SNR) was measured at the center and periphery of the b = 0 image; fractional anisotropy (FA) and mean diffusivity (MD) were assessed using phantom Slice 7. Variations of acquisition parameters and deviations from specified sequence parameters were recorded. Nonlinear grid line distortion was higher with linear shimming and could be corrected using the 2nd order shimming. Following image registration, eddy current distortion was consistently smaller than acquisi-tion voxel size. SNR was consistently higher in the image periphery than center by a factor of 1.3-2.0. ROI-based FA ranged from 0.007 to 0.024. ROI-based MD ranged from 1.90 × 10-3 to 2.33 × 10-3 mm2/s (median = 2.04 × 10-3 mm2/s). Two sites had image void artifacts. The ACR phantom can be used to compare key qual-ity measures of diffusion images acquired from multiple vendors at multiple sites.

Incorporating Sustainability into Site Closure - A Field Example

Science.gov (United States)

Austrins, L. M.; West, J.

2013-12-01

Long term management of former chemical production facilities can be a costly and time consuming element of site closure, however, implementation of creative measures to introduce sustainability and reduce the need for onsite presence can be successfully incorporated into the site closure process. A case study demonstrating this involves a facility located in Sarnia, Ontario, which was an active multi chemical production facility from the 1940s, until it was decommissioned and sold between 2005 and 2010. The facility consisted of 322 acres of production areas. Several elements which allowed for reduced onsite presence and lower management costs were incorporated into the site decommissioning plan, including; phased remediation planning, and selection of sustainable components as part of remediation, surface water management, and groundwater management. The sustainability and management modifications were successfully negotiated and approved by the local regulatory agency. Due to the size and complexity of the site, a holistic approach for the facility was needed and included the development of a comprehensive decision matrix. Each remediation alternative incorporated sustainable practices. Ex-situ remediation consisted of excavation of contaminated subsurface medium and consolidation at a 4.7 acre onsite soil treatment area designed specifically for the site closure process. In-situ remediation consisted of injection of amendment into the native soils using hydraulic fracture and injection. When the plant was an active operating facility, groundwater management required active pumping and groundwater treatment through a series of carbon treatment units. Active pumping has been replaced by passive hydraulic control through the use of tree plantations.

Distribuição e impacto da sigatoka-negra na bananicultura do estado do Acre

OpenAIRE

Cavalcante, Maria de Jesus B.; Sá, Claudenor P. de; Gomes, Francisco C. da Rocha; Gondim, Tarcísio M. de Souza; Cordeiro, Zilton J. M.; Hessel, Jorge L.

2004-01-01

A sigatoka-negra (Mycosphaerella fijiensis) é a doença de maior severidade que afeta as cultivares de banana (Musa spp.) de importância econômica no mundo. Foi constatada no Brasil em 1998, no Estado do Amazonas, e tem se disseminado pelo Estado do Acre, atacando severamente as cultivares do Subgrupo Terra (AAB). Realizou-se um diagnóstico da sigatoka-negra e dos impactos econômicos causados por esta doença nos municípios do Estado do Acre. Foram visitados plantios em 16 municípios e amostras...

Combating obsolescence - ACR digital control systems design

International Nuclear Information System (INIS)

Tikku, S.; Raiskums, G.

2006-01-01

The ever increasing use of digital technologies and products to meet the control, automation and monitoring needs of the nuclear power plant - even though justified by the benefits it provides - comes with an increased risk of technological obsolescence happening through the course of the plant life. Some well considered strategies are being employed in the ACR design process to minimise this risk and alleviate the consequence if it happens. These include application of a modular overall architecture, adoption of international widely accepted standards to harmonise equipment qualification and software practices, production of control functional specifications that are not influenced by target platform, and careful selection of technologies and products. (author)

Identifying efficiency trends for Queensland broad-acre beef enterprises

OpenAIRE

Gregg, Daniel; Rolfe, John

2010-01-01

Productivity and efficiency improvements in agriculture have recently been targeted as Federal Government priorities in Australia. This research examined a dataset of 116 broad-acre beef enterprises from Queensland who participated in a program, Profit Probe, developed to improve management and profitability of enterprises. The aim of this research was to identify the sources, if any, of productivity growth for this sample of enterprises. Two potential sources of productivity growth were iden...

77 FR 19001 - Foreign-Trade Zone 94-Laredo, TX; Application for Reorganization Under Alternative Site Framework

Science.gov (United States)

2012-03-29

... Portal Industrial Park, 8421 Amparan Road, Laredo; and, Site 11 (3.463 acres, expires 9/ 30/14)--Sony... be able to serve sites throughout the service area based on companies' needs for FTZ designation. The... facts and information presented in the application and case record and to report findings and...

Family Forest Ownerships with 10+ Acres in Texas, 2011-2013

Science.gov (United States)

Brett J. Butler; Sarah M. Butler

2016-01-01

The U.S. Forest Service, Forest Inventory and Analysis program conducts the National Woodland Owner Survey in order to better understand: who owns America's forests, why they own it, what they have done with it in the past, and what they intend to do with it in the future. This document summarizes data on family forest ownerships with 10+ acres in Texas. These...

Family Forest Ownerships with 10+ Acres in Pennsylvania, 2011-2013

Science.gov (United States)

Brett J. Butler; Sarah M. Butler

2016-01-01

The U.S. Forest Service, Forest Inventory and Analysis program conducts the National Woodland Owner Survey in order to better understand: who owns America's forests, why they own it, what they have done with it in the past, and what they intend to do with it in the future. This document summarizes data on family forest ownerships with 10+ acres in Pennsylvania....

Assessment of ACR moderator circulation design using CFD

International Nuclear Information System (INIS)

Bunama, R.; Carlucci, L.N.; Waddington, G.M.

2004-01-01

Assessment of the thermalhydraulic performance of the moderator circulation system for the Advanced CANDU Reactor (ACR) was carried out using the specialized Computational Fluid Dynamics (CFD) code MODTURC C LAS V2.9 IST. The assessment included modeling the moderator circulation inside the calandria vessel under nominal and isothermal flow conditions. The modeling results show that the moderator flow through the core is relatively uniform and mostly upward. The moderator temperature distribution is nearly stratified and increases monotonically from the bottom to the top of the calandria vessel. (author)

Variación de la estructura fina de las fibras acrílicas en la hilatura

OpenAIRE

Gacén Guillén, Joaquín; Maillo Garrido, Josefina; Manich i Bou, Albert Mª; Ussmane, Mahomed

2002-01-01

[ESP] Dos fibras acrílicas comerciales de diferente finura han sido transformadas en hilados en continua de hilar (3.3. dtex) y en hilatura de rotor (1.3 dtex). Los hilos resultantes han sido vaporizados y teñidos en condiciones standard. Las variaciones de la estructura producidas por las operaciones de hilatura, vaporizado y tintura han sido evaluadas a través del ensayo de solubilidad de las fibras acrílicas en una mezcla dimetilformamida/agua (95/5).

Illinois' Forests 2005

Science.gov (United States)

Susan J. Crocker; Gary J. Brand; Brett J. Butler; David E. Haugen; Dick C. Little; Dacia M. Meneguzzo; Charles H. Perry; Ronald J. Piva; Barry T. Wilson; Christopher W. Woodall

2009-01-01

The first full, annualized inventory of Illinois' forests reports more than 4.5 million acres of forest land with an average of 459 trees per acre. Forest land is dominated by oak/hickory forest types, which occupy 65 percent of total forest land area. Seventy-two percent of forest land consists of sawtimber, 20 percent contains poletimber, and 8 percent contains...

Post-Closure Inspection, Sampling, and Maintenance Report for the Salmon, Mississippi, Site Calendar Year 2011

Energy Technology Data Exchange (ETDEWEB)

None

2012-03-01

This report summarizes the 2011 annual inspection, sampling, measurement, and maintenance activities performed at the Salmon, Mississippi, Site (Salmon site1). The draft Long-Term Surveillance and Maintenance Plan for the Salmon Site, Lamar County, Mississippi (DOE 2007) specifies the submittal of an annual report of site activities with the results of sample analyses. The Salmon site consists of 1,470 acres. The site is located in Lamar County, Mississippi, approximately 10 miles west of Purvis, Mississippi, and about 21 miles southwest of Hattiesburg, Mississippi.

Evaluation of the ACR and SLICC classification criteria in juvenile-onset systemic lupus erythematosus: a longitudinal analysis.

Science.gov (United States)

Lythgoe, H; Morgan, T; Heaf, E; Lloyd, O; Al-Abadi, E; Armon, K; Bailey, K; Davidson, J; Friswell, M; Gardner-Medwin, J; Haslam, K; Ioannou, Y; Leahy, A; Leone, V; Pilkington, C; Rangaraj, S; Riley, P; Tizard, E J; Wilkinson, N; Beresford, M W

2017-10-01

Objectives The Systemic Lupus International Collaborating Clinics (SLICC) group proposed revised classification criteria for systemic lupus erythematosus (SLICC-2012 criteria). This study aimed to compare these criteria with the well-established American College of Rheumatology classification criteria (ACR-1997 criteria) in a national cohort of juvenile-onset systemic lupus erythematosus (JSLE) patients and evaluate how patients' classification criteria evolved over time. Methods Data from patients in the UK JSLE Cohort Study with a senior clinician diagnosis of probable evolving, or definite JSLE, were analyzed. Patients were assessed using both classification criteria within 1 year of diagnosis and at latest follow up (following a minimum 12-month follow-up period). Results A total of 226 patients were included. The SLICC-2012 was more sensitive than ACR-1997 at diagnosis (92.9% versus 84.1% p < 0.001) and after follow up (100% versus 92.0% p < 0.001). Most patients meeting the SLICC-2012 criteria and not the ACR-1997 met more than one additional criterion on the SLICC-2012. Conclusions The SLICC-2012 was better able to classify patients with JSLE than the ACR-1997 and did so at an earlier stage in their disease course. SLICC-2012 should be considered for classification of JSLE patients in observational studies and clinical trial eligibility.

Fluorescence-based thermal shift data on multidrug regulator AcrR from Salmonella enterica subsp. entrica serovar Typhimurium str. LT2.

Science.gov (United States)

Manjasetty, Babu A; Halavaty, Andrei S; Luan, Chi-Hao; Osipiuk, Jerzy; Mulligan, Rory; Kwon, Keehwan; Anderson, Wayne F; Joachimiak, Andrzej

2016-06-01

The fluorescence-based thermal shift (FTS) data presented here include Table S1 and Fig. S1, and are supplemental to our original research article describing detailed structural, FTS, and fluorescence polarization analyses of the Salmonella enterica subsp. entrica serovar Typhimurium str. LT2 multidrug transcriptional regulator AcrR (StAcrR) (doi:10.1016/j.jsb.2016.01.008) (Manjasetty et al., 2015 [1]). Table S1 contains chemical formulas, a Chemical Abstracts Service (CAS) Registry Number (CAS no.), FTS rank (a ligand with the highest rank) has the largest difference in the melting temperature (ΔT m), and uses as drug molecules against various pathological conditions of sixteen small-molecule ligands that increase thermal stability of StAcrR. Thermal stability of human enolase 1, a negative control protein, was not affected in the presence of various concentrations of the top six StAcrR binders (Fig. S1).

Ten-Year Effect of Six Site-Preparation Treatments on Piedmont Loblolly Pine Survival and Growth

Science.gov (United States)

M. Boyd Edwards

1994-01-01

Limited information is available on growth responses to different levels of intensity for site preparation in the Piedmont. In the present study, six intensities of site preparation were compared for their effect on survival, height and diameter growth, total volume produced, and basal area per acre for the first 10 years after treatment. Rates of survival and growth...

Variación de la estructura fina de las fibras acrílicas en la hilatura

OpenAIRE

Gacén Guillén, Joaquín; Maillo Garrido, Josefina; Manich i Bou, Albert Mª; Ussmane, Mahomed

2002-01-01

Dos fibras acrílicas comerciales de diferente finura han sido transformadas en hilados en continua de hilar (3.3. dtex) y en hilatura de rotor (1.3 dtex). Los hilos resultantes han sido vaporizados y teñidos en condiciones standard. Las variaciones de la estructura producidas por las operaciones de hilatura, vaporizado y tintura han sido evaluadas a través del ensayo de solubilidad de las fibras acrílicas en una mezcla dimetilformamida/agua (95/5). Two commercial acrylic fibres of d...

A GIS approach for predicting prehistoric site locations.

Energy Technology Data Exchange (ETDEWEB)

Kuiper, J. A.; Wescott, K. L.

1999-08-04

Use of geographic information system (GIS)-based predictive mapping to locate areas of high potential for prehistoric archaeological sites is becoming increasingly popular among archaeologists. Knowledge of the environmental variables influencing activities of original inhabitants is used to produce GIS layers representing the spatial distribution of those variables. The GIS layers are then analyzed to identify locations where combinations of environmental variables match patterns observed at known prehistoric sites. Presented are the results of a study to locate high-potential areas for prehistoric sites in a largely unsurveyed area of 39,000 acres in the Upper Chesapeake Bay region, including details of the analysis process. The project used environmental data from over 500 known sites in other parts of the region and the results corresponded well with known sites in the study area.

Rocketdyne Propulsion & Power DOE Operations Annual Site Environmental Report 1996

Energy Technology Data Exchange (ETDEWEB)

Tuttle, R. J. [The Boeing Company, Canoga Park, CA (United States)

1997-11-10

This annual report discusses environmental monitoring at two manufacturing and test operations sites operated in the Los Angeles area by Rocketdyne Propulsion & Power of Boeing North American. Inc. (formerly Rockwell International Corporation). These are identified as the Santa Susana Field Laboratory (SSFL and the De Soto site. The sites have been used for manufacturing; R&D, engineering, and testing in a broad range of technical fields, primarily rocket engine propulsion and nuclear reactor technology. The De Soto site essentially comprises office space and light industry with no remaining radiological operations, and has little potential impact on the environment. The SSFL site, because of its large size (2.668 acres), warrants comprehensive monitoring to ensure protection of the environment.

The advantages of PD1 activating chimeric receptor (PD1-ACR) engineered lymphocytes for PDL1(+) cancer therapy.

Science.gov (United States)

Tang, Xiaolong; Li, Qingguo; Zhu, Yongqiang; Zheng, Donghui; Dai, Jingjing; Ni, Wenxuan; Wei, Jia; Xue, Yubao; Chen, Ke; Hou, Wei; Zhang, Chao; Feng, Xiaojun; Liang, Yong

2015-01-01

Tumors exploit immunoregulatory checkpoints to attenuate T cell responses as a means of circumventing immunologic rejection. By activating the inhibitory costimulatory pathway of Programmed Death 1 (PD1)/PDL1 which provides tumor cells an escape mechanism from immune surveillance, Programmed Death Ligand1 (PDL1)(+) tumors hamper activated tumor-specific T cell functions and render them functionally exhausted. To overcome the inhibitory costimulatory effects of PDL1 on the adoptively transferred T cells, we sought to convert PD1 to a T cell costimulatory receptor by exchanging its transmembrane and cytoplasmic tail with CD28 and 4-1BB signaling domains (PD1-CD28-4-1BB, PD1-ACR), anticipating the genetically modified effector T lymphocytes expressing PD1-ACR would exhibit enhanced functional attributes. And the results showed that PD1-ACR expressed T cells retained the ability to bind PDL1, resulting in T cell activation as evidenced by the elevated activity of phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), the augmentation of cytokine secretion and the increased proliferative capacity. Moreover, when systemically administered in the mouse model of glioblastoma metastases, PD1-ACR T cells localized at the area of U87 invasive tumor, which results in suppressed tumor growth and enhanced survival of mice with established U87 glioblastoma. Together, these data demonstrated that PD1-ACR has a high potential to serve as a novel strategy to overcome PDL1 mediated immunosuppression of T cells for cancer therapy.

(S-5-ethynyl-anabasine, a novel compound, is a more potent agonist than other nicotine alkaloids on the nematode Asu-ACR-16 receptor

Directory of Open Access Journals (Sweden)

Fudan Zheng

2017-04-01

Here, we describe the synthesis of a novel agonist, (S-5-ethynyl-anabasine, and show that it is more potent (EC50 0.14 ± 0.01 μM than other nicotine alkaloids on Asu-ACR-16. Agonists acting on ACR-16 receptors have the potential to circumvent drug resistance to anthelmintics, like levamisole, that do not act on the ACR-16 receptors.

Fluorescence-based thermal shift data on multidrug regulator AcrR from Salmonella enterica subsp. entrica serovar Typhimurium str. LT2

Directory of Open Access Journals (Sweden)

Babu A. Manjasetty

2016-06-01

Full Text Available The fluorescence-based thermal shift (FTS data presented here include Table S1 and Fig. S1, and are supplemental to our original research article describing detailed structural, FTS, and fluorescence polarization analyses of the Salmonella enterica subsp. entrica serovar Typhimurium str. LT2 multidrug transcriptional regulator AcrR (StAcrR (doi:10.1016/j.jsb.2016.01.008 (Manjasetty et al., 2015 [1]. Table S1 contains chemical formulas, a Chemical Abstracts Service (CAS Registry Number (CAS no., FTS rank (a ligand with the highest rank has the largest difference in the melting temperature (ΔTm, and uses as drug molecules against various pathological conditions of sixteen small-molecule ligands that increase thermal stability of StAcrR. Thermal stability of human enolase 1, a negative control protein, was not affected in the presence of various concentrations of the top six StAcrR binders (Fig. S1.

Rocketdyne Division annual site environmental report Santa Susana Field Laboratory and Desoto sites 1995

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-07-30

This annual report discusses environmental monitoring at two manufacturing and test operations sites operated in the Los Angeles area by the Rocketdyne Division of Rockwell International Corporation (Rocketdyne). These are identified as the Santa Susana Field Laboratory (SSFL) and the DeSoto site. The sites have been used for manufacturing, R&D, engineering, and testing in a broad range of technical fields, primarily rocket engine propulsion and nuclear reactor technology. The DeSoto site essentially comprises office space and light industry with no remaining radiological operations, and has little potential impact on the environment. The SSFL site, because of its large size (2,668 acres), warrants comprehensive monitoring to assure protection of the environment. SSFL consists of four administrative areas used for research, development, and test operations as well as a buffer zone. A portion of Area I and all of Area II are owned by the U.S. Government and assigned to the National Aeronautics and Space Administration (NASA). A portion of Area IV is under option for purchase by the Department of Energy (DOE).

Rocketdyne Division annual site environmental report Santa Susana Field Laboratory and Desoto sites 1995

International Nuclear Information System (INIS)

1996-01-01

This annual report discusses environmental monitoring at two manufacturing and test operations sites operated in the Los Angeles area by the Rocketdyne Division of Rockwell International Corporation (Rocketdyne). These are identified as the Santa Susana Field Laboratory (SSFL) and the DeSoto site. The sites have been used for manufacturing, R ampersand D, engineering, and testing in a broad range of technical fields, primarily rocket engine propulsion and nuclear reactor technology. The DeSoto site essentially comprises office space and light industry with no remaining radiological operations, and has little potential impact on the environment. The SSFL site, because of its large size (2,668 acres), warrants comprehensive monitoring to assure protection of the environment. SSFL consists of four administrative areas used for research, development, and test operations as well as a buffer zone. A portion of Area I and all of Area II are owned by the U.S. Government and assigned to the National Aeronautics and Space Administration (NASA). A portion of Area IV is under option for purchase by the Department of Energy (DOE)

ACR appropriateness criteria jaundice.

Science.gov (United States)

Lalani, Tasneem; Couto, Corey A; Rosen, Max P; Baker, Mark E; Blake, Michael A; Cash, Brooks D; Fidler, Jeff L; Greene, Frederick L; Hindman, Nicole M; Katz, Douglas S; Kaur, Harmeet; Miller, Frank H; Qayyum, Aliya; Small, William C; Sudakoff, Gary S; Yaghmai, Vahid; Yarmish, Gail M; Yee, Judy

2013-06-01

A fundamental consideration in the workup of a jaundiced patient is the pretest probability of mechanical obstruction. Ultrasound is the first-line modality to exclude biliary tract obstruction. When mechanical obstruction is present, additional imaging with CT or MRI can clarify etiology, define level of obstruction, stage disease, and guide intervention. When mechanical obstruction is absent, additional imaging can evaluate liver parenchyma for fat and iron deposition and help direct biopsy in cases where underlying parenchymal disease or mass is found. Imaging techniques are reviewed for the following clinical scenarios: (1) the patient with painful jaundice, (2) the patient with painless jaundice, and (3) the patient with a nonmechanical cause for jaundice. The ACR Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed every 2 years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer-reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel. In those instances where evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatment. Copyright © 2013 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Indiana's Forests 2008

Science.gov (United States)

Christopher W. Woodall; Mark N. Webb; Barry T. Wilson; Jeff Settle; Ron J. Piva; Charles H. Perry; Dacia M. Meneguzzo; Susan J. Crocker; Brett J. Butler; Mark Hansen; Mark Hatfield; Gary Brand; Charles. Barnett

2011-01-01

The second full annual inventory of Indiana's forests reports more than 4.75 million acres of forest land with an average volume of more than 2,000 cubic feet per acre. Forest land is dominated by the white oak/red oak/hickory forest type, which occupies nearly a third of the total forest land area. Seventy-six percent of forest land consists of sawtimber, 16...

Crystallization and preliminary crystallographic characterization of LmACR2, an arsenate/antimonate reductase from Leishmania major

Energy Technology Data Exchange (ETDEWEB)

Bisacchi, Davide [Bioinformatics and Structural Proteomics, IST-National Cancer Research Institute, Genova (Italy); Zhou, Yao; Rosen, Barry P.; Mukhopadhyay, Rita [Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan (United States); Bordo, Domenico, E-mail: domenico.bordo@istge.it [Bioinformatics and Structural Proteomics, IST-National Cancer Research Institute, Genova (Italy)

2006-10-01

LmACR2 from L. major is the first rhodanese-like enzyme directly involved in the reduction of arsenate and antimonate to be crystallized. Diffraction data have been collected to 1.99 Å resolution using synchrotron X-rays. Arsenic is present in the biosphere owing either to the presence of pesticides and herbicides used in agricultural and industrial activities or to leaching from geological formations. The health effects of prolonged exposure to arsenic can be devastating and may lead to various forms of cancer. Antimony(V), which is chemically very similar to arsenic, is used instead in the treatment of leishmaniasis, an infection caused by the protozoan parasite Leishmania sp.; the reduction of pentavalent antimony contained in the drug Pentostam to the active trivalent form arises from the presence in the Leishmania genome of a gene, LmACR2, coding for the protein LmACR2 (14.5 kDa, 127 amino acids) that displays weak but significant sequence similarity to the catalytic domain of Cdc25 phosphatase and to rhodanese enzymes. For structural characterization, LmACR2 was overexpressed, purified to homogeneity and crystallized in a trigonal space group (P321 or P3{sub 1}21/P3{sub 2}21). The protein crystallized in two distinct trigonal crystal forms, with unit-cell parameters a = b = 111.0, c = 86.1 Å and a = b = 111.0, c = 175.6 Å, respectively. At a synchrotron beamline, the diffraction pattern extended to a resolution limit of 1.99 Å.

Crystallization and preliminary crystallographic characterization of LmACR2, an arsenate/antimonate reductase from Leishmania major

International Nuclear Information System (INIS)

Bisacchi, Davide; Zhou, Yao; Rosen, Barry P.; Mukhopadhyay, Rita; Bordo, Domenico

2006-01-01

LmACR2 from L. major is the first rhodanese-like enzyme directly involved in the reduction of arsenate and antimonate to be crystallized. Diffraction data have been collected to 1.99 Å resolution using synchrotron X-rays. Arsenic is present in the biosphere owing either to the presence of pesticides and herbicides used in agricultural and industrial activities or to leaching from geological formations. The health effects of prolonged exposure to arsenic can be devastating and may lead to various forms of cancer. Antimony(V), which is chemically very similar to arsenic, is used instead in the treatment of leishmaniasis, an infection caused by the protozoan parasite Leishmania sp.; the reduction of pentavalent antimony contained in the drug Pentostam to the active trivalent form arises from the presence in the Leishmania genome of a gene, LmACR2, coding for the protein LmACR2 (14.5 kDa, 127 amino acids) that displays weak but significant sequence similarity to the catalytic domain of Cdc25 phosphatase and to rhodanese enzymes. For structural characterization, LmACR2 was overexpressed, purified to homogeneity and crystallized in a trigonal space group (P321 or P3 1 21/P3 2 21). The protein crystallized in two distinct trigonal crystal forms, with unit-cell parameters a = b = 111.0, c = 86.1 Å and a = b = 111.0, c = 175.6 Å, respectively. At a synchrotron beamline, the diffraction pattern extended to a resolution limit of 1.99 Å

Parasitóides (Hymenoptera: Braconidae de Anastrepha Schiner (Diptera: Tephritidae no estado do Acre Parasitoids (Hymenoptera: Braconidae of Anastrepha Schiner (Diptera: Tephritidae in the state of Acre, Brazil

Directory of Open Access Journals (Sweden)

Marcílio José Thomazini

2009-03-01

Full Text Available Este trabalho relata a primeira ocorrência de parasitóides em moscas-das-frutas do gênero Anastrepha Schiner no estado do Acre. No município de Bujari foram encontrados os braconídeos Opius bellus Gahan (72,5%, Doryctobracon areolatus (Szépligeti (26,8% e Utetes anastrephae (Viereck (0,7% associados a A. obliqua (Macquart em frutos de taperebá (Spondias mombin L., com parasitismo de 29,5%. No município de Rio Branco, em frutos de goiaba (Psidium guajava L., ocorreu somente D. areolatus em A. obliqua com parasitismo de 2,7%.This paper records the first parasitoids occurrence on Anastrepha Schiner fruit flies in the state of Acre, Brazil. In the Bujari County there occurred the braconids Opius bellus Gahan (72.5%, Doryctobracon areolatus (Szépligeti (26.8% e Utetes anastrephae (Viereck (0.7% associated with A. obliqua (Macquart in tapereba fruits (Spondias mombin L., with parasitism of 29.5%. In guajava fruits (Psidium guajava L. at Rio Branco County, only D. areolatus on A. obliqua occurred, with parasitism of 2.7%.

New insights into the structural and functional involvement of the gate loop in AcrB export activity.

Science.gov (United States)

Ababou, Abdessamad

2018-02-01

AcrB is a major multidrug exporter in Escherichia coli and other Gram-negative bacteria. Its gate loop, located between the proximal and the distal pockets, have been reported to play important role in the export of many antibiotics. This loop location, rigidity and interactions with substrates have led recent reports to suggest that AcrB export mechanism operates in a sequential manner. First the substrate binds the proximal pocket in the access monomer, then it moves to bind the distal pocket in the binding monomer and subsequently it is extruded in the extrusion monomer. Recently, we have demonstrated that the gate loop is not required for the binding of Erythromycin but the integrity of this loop is important for an efficient export of this substrate. However, here we show that the antibiotic susceptibilities of the same AcrB gate loop mutants for Doxorubicin were unaffected, suggesting that this loop is not required for its export, and we demonstrate that this substrate may use principally the tunnel-1, located between transmembranes 8 and 9, more often than previously reported. To further explain our findings, here we address the gate loop mutations effects on AcrB solution energetics (fold, stability, molecular dynamics) and on the in vivo efflux of Erythromycin and Doxorubicin. Finally, we discuss the efflux and the discrepancy between the structural and the functional experiments for Erythromycin in these gate loop mutants. Copyright © 2017 Elsevier B.V. All rights reserved.

Molecular detection of genes encoding AcrAB , Qep A efflux pumps in Klebsiella pneumoniae strains isolated from hospitalized patients in selected hospitals in Tehran

Directory of Open Access Journals (Sweden)

Mohsen Heidary

2017-03-01

Full Text Available Abstract Background and Objectives: Increasing emergence of fluoroquinolone resistance among clinical isolates of Klebsiella pneumoniae  (K. pneumoniae, has limited the treatment options for treatment of infections caused by these bacteria. The aim of this study was to investigate the dissemination of genes encoding AcrAB and QepA efflux pumps among K. pneumoniae strains. Methods: This study was carried out on 117 K. pneumoniae strains isolated from patients hospitalized in selected hospitals in Tehran city, 2015-2016, Iran. Antimicrobial susceptibility tests were performed using disk diffusion method (based on CLSI guidelines and identification of acr A, acr B and qep A genes using PCR assay. Results: In this study, colistin and tigecycline had the best effect against clinical isolates of K. pneumoniae. According to PCR results, 110 (94% isolates had acrA gene and 102 (87% isolates had acrB gene, respectively. The qepA gene was not found in any of the K. pneumoniae strains. Conclusion: According to the results of the present study, dissemination of the genes encoding AcrAB efflux pumps among K. pneumoniae strains, which cause resistance to fluoroquinolones, is a matter of concern. Therefore, infection control and prevention of the spread of drug-resistant bacteria requires careful management in drug prescription and identification of resistant isolates.

Human intestinal parasites in crusader Acre: Evidence for migration with disease in the medieval period.

Science.gov (United States)

Mitchell, Piers D; Anastasiou, Evilena; Syon, Danny

2011-12-01

The aim of this research is to highlight the role of ancient parasites as evidence for human migration in past populations. The material analysed was soil sediment from the excavation of a medieval cesspool in the city of Acre, in Israel. Archaeological stratigraphy and radiocarbon dating of a fragment of animal bone from the cesspool confirm its use in the 13th century CE, during the crusader period. At that time Acre was located in the Frankish Kingdom of Jerusalem. Soil samples from the cesspool were analysed and eggs of the roundworm (Ascaris lumbricoides) and fish tapeworm (Diphyllobothrium latum) were identified. The fish tapeworm has only been found in the mainland Near East once before, in a latrine of the crusader Order of St. John (Knights Hospitaller). It has been absent in all earlier cesspools, latrines and coprolites so far studied in the region. In contrast to its rarity in the Levant, the fish tapeworm was common in northern Europe during the medieval period. The presence of fish tapeworm eggs in a crusader period cesspool in Acre suggests its use by crusaders or pilgrims from northern Europe who travelled to the Levant carrying these parasites in their intestines. Copyright © 2011 Elsevier Inc. All rights reserved.

Amphibia, Anura, Microhylidae, Chiasmocleis avilapiresae Peloso and Sturaro, 2008: First record from the state of Acre, southwestern Amazonia, Brazil

Directory of Open Access Journals (Sweden)

Sampaio, P. R. M.

2010-01-01

Full Text Available We record for the first time the presence of Chiasmocleis avilapiresae in the state of Acre, Brazil. This microhylidfrog is found throughout Amazon in Brazil and no information about its distribution in the Acre state was reported previously.An increase on sampling efforts, revision of material housed in herpetological collections, and use of diverse herpetofaunasampling methods might reveal additional localities and more information about this species.

Amphibia, Anura, Microhylidae, Chiasmocleis avilapiresae Peloso and Sturaro, 2008: first record for the state of Acre, southwestern Amazonia, Brazil

OpenAIRE

Sampaio, Paulo; da Silva, Talisson; Peloso, Pedro

2016-01-01

We record for the first time the presence of Chiasmocleis avilapiresae in the state of Acre, Brazil. This microhylid frog is found throughout Amazon in Brazil and no information about its distribution in the Acre state was reported previously. An increase on sampling efforts, revision of material housed in herpetological collections, and use of diverse herpetofauna sampling methods might reveal additional localities and more information about this species.

Rocketdyne division annual site environmental report, Santa Susana Field Laboratory and De Soto Sites, 1992

Energy Technology Data Exchange (ETDEWEB)

none,

1993-12-14

This annual report discusses environmental monitoring at two manufacturing and test operations sites operated in the Los Angeles area by the Rocketdyne Division of Rockwell International Corporation. These are identified as the Santa Susana Field Laboratory (SSFL) and the De Soto site. These sites have been used for manufacturing, R&D, engineering, and testing in a broad range of technical fields, primarily rocket engine propulsion and nuclear reactor technology. The De Soto site is essentially light industry with some laboratory-scale R&D and has little potential impact on the environment. The SSFL site, because of its large size (2,668 acres), warranted comprehensive monitoring to assure protection of the environment. The purpose of this report is to present information on environmental and effluent monitoring primarily for the regulatory agencies involved in controlling environmental remediation, i.e., the U.S. DOE, the Nuclear Regulatory Commission (NRC), and the California State Department of Health Services (DHS) Radiologic Health Branch (RHB). For that reason, information concentrates on Area IV at SSFL as this is the site of the former nuclear operations. While the major area of interest is radiological, this report also includes a discussion of nonradiological monitoring at SSFL.

Rocketdyne division annual site environmental report, Santa Susana Field Laboratory and De Soto Site, 1991

Energy Technology Data Exchange (ETDEWEB)

none,

1992-12-03

This annual report discusses environmental monitoring at two manufacturing and test operations sites operated in the Los Angeles area by the Rocketdyne Division of Rockwell International Corporation. These are identified as the Santa Susana Field Laboratory (SSFL) and the De Soto site. These sites have been used for manufacturing, R&D, engineering, and testing in a broad range of technical fields, primarily rocket engine propulsion and nuclear reactor technology. The De Soto site is essentially light industry with some laboratory-scale R&D and has little potential impact on the environment. The SSFL site, because of its large size (2.668 acres), warranted comprehensive monitoring to assure protection of the environment. The purpose of this report is to present information on environmental and effluent monitoring primarily for the regulatory agencies involved in controlling operations with nuclear fuel or nuclear reactors. i.e., the U.S. DOE and the California State Department of Health Services (DHS). Radiologic Health Branch (RHB). For that reason. information concentrates on Area IV at SSFL as this is the site of the former nuclear operations. While the major area of interest is radiological, this report also includes a discussion of nonradiological monitoring at SSFL.

Rocketdyne division annual site environmental report, Santa Susana Field Laboratory and De Soto Sites, 1993

Energy Technology Data Exchange (ETDEWEB)

None, None

1994-10-21

This annual report discusses environmental monitoring at two manufacturing and test operations sites operated in the Los Angeles area by the Rocketdyne Division of Rockwell International Corporation. These are identified as the Santa Susana Field Laboratory (SSFL) and the De Soto site. These sites have been used for manufacturing, R&D, engineering, and testing in a broad range of technical fields, primarily rocket engine propulsion and nuclear reactor technology. The De Soto site is essentially light industry with some laboratory-scale R&D and has little potential impact on the environment. The SSFL site, because of its large size (2,668 acres), warranted comprehensive monitoring to assure protection of the environment. The purpose of this report is to present information on environmental and effluent monitoring primarily for the regulatory agencies involved in controlling environmental remediation, i.e., the U.S. DOE, the Nuclear Regulatory Commission (NRC), and the California State Department of Health Services (DHS) Radiologic Health Branch (RHB). For that reason, information concentrates on Area IV at SSFL as this is the site of the former nuclear operations. While the major area of interest is radiological, this report also includes a discussion of nonoradiological monitoring at SSFL.

Bikeability and methodological issues using the active commuting route environment scale (ACRES in a metropolitan setting

Directory of Open Access Journals (Sweden)

Schantz Peter

2011-01-01

Full Text Available Abstract Background Route environments can positively influence people's active commuting and thereby contribute to public health. The Active Commuting Route Environment Scale (ACRES was developed to study active commuters' perceptions of their route environments. However, bicycle commuters represent a small portion of the population in many cities and thus are difficult to study using population-based material. Therefore, the aim of this study is to expand the state of knowledge concerning the criterion-related validity of the ACRES and the representativity using an advertisement-recruited sample. Furthermore, by comparing commuting route environment profiles of inner urban and suburban areas, we provide a novel basis for understanding the relationship between environment and bikeability. Methods Bicycle commuters from Greater Stockholm, Sweden, advertisement- (n = 1379 and street-recruited (n = 93, responded to the ACRES. Traffic planning and environmental experts from the Municipality of Stockholm (n = 24 responded to a modified version of the ACRES. The criterion-related validity assessments were based on whether or not differences between the inner urban and the suburban route environments, as indicated by the experts and by four existing objective measurements, were reflected by differences in perceptions of these environments. Comparisons of ratings between advertisement- and street-recruited participants were used for the assessments of representativity. Finally, ratings of inner urban and suburban route environments were used to evaluate commuting route environment profiles. Results Differences in ratings of the inner urban and suburban route environments by the advertisement-recruited participants were in accord with the existing objective measurements and corresponded reasonably well with those of the experts. Overall, there was a reasonably good correspondence between the advertisement- and street-recruited participants' ratings

Bikeability and methodological issues using the active commuting route environment scale (ACRES) in a metropolitan setting.

Science.gov (United States)

Wahlgren, Lina; Schantz, Peter

2011-01-17

Route environments can positively influence people's active commuting and thereby contribute to public health. The Active Commuting Route Environment Scale (ACRES) was developed to study active commuters' perceptions of their route environments. However, bicycle commuters represent a small portion of the population in many cities and thus are difficult to study using population-based material. Therefore, the aim of this study is to expand the state of knowledge concerning the criterion-related validity of the ACRES and the representativity using an advertisement-recruited sample. Furthermore, by comparing commuting route environment profiles of inner urban and suburban areas, we provide a novel basis for understanding the relationship between environment and bikeability. Bicycle commuters from Greater Stockholm, Sweden, advertisement- (n = 1379) and street-recruited (n = 93), responded to the ACRES. Traffic planning and environmental experts from the Municipality of Stockholm (n = 24) responded to a modified version of the ACRES. The criterion-related validity assessments were based on whether or not differences between the inner urban and the suburban route environments, as indicated by the experts and by four existing objective measurements, were reflected by differences in perceptions of these environments. Comparisons of ratings between advertisement- and street-recruited participants were used for the assessments of representativity. Finally, ratings of inner urban and suburban route environments were used to evaluate commuting route environment profiles. Differences in ratings of the inner urban and suburban route environments by the advertisement-recruited participants were in accord with the existing objective measurements and corresponded reasonably well with those of the experts. Overall, there was a reasonably good correspondence between the advertisement- and street-recruited participants' ratings. Distinct differences in commuting route environment

Switch loop flexibility affects substrate transport of the AcrB efflux pump

International Nuclear Information System (INIS)

Muller, Reinke T.; Travers, Timothy; Cha, Hi-jea; Phillips, Joshua L.

2017-01-01

The functionally important switch-loop of the trimeric multidrug transporter AcrB separates the access and deep drug binding pockets in every protomer. This loop, comprising 11 amino acid residues, has been shown to be crucial for substrate transport, as drugs have to travel past the loop to reach the deep binding pocket and from there are transported outside the cell via the connected AcrA and TolC channels. It contains four symmetrically arranged glycine residues suggesting that flexibility is a key feature for pump activity. Upon combinatorial substitution of these glycine residues to proline, functional and structural asymmetry was observed. Proline substitutions on the PC1 proximal side completely abolished transport and reduced backbone flexibility of the switch loop, which adopted a conformation restricting the pathway towards the deep binding pocket. Here, two phenylalanine residues located adjacent to the substitution sensitive glycine residues play a role in blocking the pathway upon rigidification of the loop, since the removal of the phenyl rings from the rigid loop restores drug transport activity.

Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB.

Science.gov (United States)

Eicher, Thomas; Seeger, Markus A; Anselmi, Claudio; Zhou, Wenchang; Brandstätter, Lorenz; Verrey, François; Diederichs, Kay; Faraldo-Gómez, José D; Pos, Klaas M

2014-09-19

Membrane transporters of the RND superfamily confer multidrug resistance to pathogenic bacteria, and are essential for cholesterol metabolism and embryonic development in humans. We use high-resolution X-ray crystallography and computational methods to delineate the mechanism of the homotrimeric RND-type proton/drug antiporter AcrB, the active component of the major efflux system AcrAB-TolC in Escherichia coli, and one most complex and intriguing membrane transporters known to date. Analysis of wildtype AcrB and four functionally-inactive variants reveals an unprecedented mechanism that involves two remote alternating-access conformational cycles within each protomer, namely one for protons in the transmembrane region and another for drugs in the periplasmic domain, 50 Å apart. Each of these cycles entails two distinct types of collective motions of two structural repeats, coupled by flanking α-helices that project from the membrane. Moreover, we rationalize how the cross-talk among protomers across the trimerization interface might lead to a more kinetically efficient efflux system.

Brazilian Feminism Since the Seventies: Revisiting a Trajectory

Directory of Open Access Journals (Sweden)

Cynthia Andersen Sarti

2004-01-01

Full Text Available Based on the Brazilian experience in the last decades, the text approaches feminism as a phenomenon that, although enunciating women’s emancipation in general and abstract terms, concretizes itself in specific social, cultural, political and historical contexts. Initially, the article shows feminism in Brazil, in the seventies, as a women’s movement that was framed in opposition to the military dictatorship. In the following decades, it developed within the possibilities and limits of the process of political democratization. Nevertheless, the text argues that the difficulties faced by Brazilian feminism concerns not only the conjuncture constraints, but are related to structural impasses of feminism, due to the fact that women are not a universal category, except by the projection of our own cultural references. Their cultural and social existence implies diversity and institutes boundaries that cut the world culturally identified as feminine. As such, the analysis of feminism requires the reference to the context of its enunciation, which gives its meaning. Accordingly, the analysis of gender relations implies considering the notion of the person as conceived in the symbolic universe to which they refer.

Environmental assessment of remedial action at the Gunnison Uranium Mill Tailings Site, Gunnison, Colorado

International Nuclear Information System (INIS)

Bachrach, A.; Hoopes, J.; Morycz, D.; Bone, M.; Cox, S.; Jones, D.; Lechel, D.; Meyer, C.; Nelson, M.; Peel, R.; Portillo, R.; Rogers, L.; Taber, B.; Zelle, P.; Rice, G.

1984-12-01

This document assesses and compares the environmental impacts of various alternatives for remedial action at the Gunnison uranium of mill tailings site located 0.5 miles south of Gunnison, Colorado. The site covers 56 acres and contains 35 acres of tailings, 2 of the original mill buildings and a water tower. The Uranium Mill Tailings Radiation Control of Act of 1978 (UMTRCA), Public Law 95-604, authorizes the US Department of Energy to clean up the site to reduce the potential health impacts associated with the residual radioactive materials remaining at the site and at associated [vicinity] properties off the site. The US Environmental Protection Agency promulgated standards for the remedial actions (40 CFR 192). Remedial actions must be performed in accordance with these standards and with the occurrence of the Nuclear Regulatory Commission. Four alternatives have been addressed in this document. The first alternative is to consolidate the tailings and associated contaminated soils into a recontoured pile on the southern portion of the existing site. A radon barrier of silty clay would be constructed over the pile and various erosion control measures would be taken to assure the long-term integrity of the pile. Two other alternatives which involve moving the tailings to new locations are assessed in this document. These alternatives generally involve greater short-term impacts and are more costly but would result in the tailings being stabilized in a location farther from the city of Gunnison. The no action alternative is also assessed

Site characterization design and techniques used at the Southern Shipbuilding Corporation site

International Nuclear Information System (INIS)

Mueller, J.P.; Geraghty, C.A.; Moore, G.W.; Mullins, J.R.

1995-01-01

The Southern Shipbuilding Corporation (SSC) site is an inactive barge/ship manufacturing and repair facility situated on approximately 54 acres in Slidell, St. Tammany Parish, Louisiana. Two unlined surface impoundments (North and South impoundments) are situated on the northwest portion of the site and are surrounded on three sides by Bayou Bonfouca. These impoundments are the sources of carcinogenic polynuclear aromatic hydrocarbon (CPAH) contamination at the site. Inadequate containment has resulted in the release of impoundment wastes into the bayou. To evaluate potential response alternatives for the site, an Engineering Evaluation/Cost Analysis (EE/CA) field investigation was conducted from July through October 1994. A two phase sampling approach was used in combination with innovative and traditional sampling techniques, field screening technologies, and exploitation of the visual characteristics of the waste to determine the extent of waste migration with limited off-site laboratory confirmation. A skid-mounted mobile drilling unit, secured to a specialized sampling platform designed for multiple applications, was used for collection of sediment cores from the bayou as well as tarry sludge cores from the impoundments. Field screening of core samples was accomplished on site using an organic vapor analyzer and a total petroleum hydrocarbon (TPH) field analyzer. Pollutants of concern include metals, cyanide, dioxin, and organic compounds. This paper presents details on the sampling design and characterization techniques used to accomplish the EE/CA field investigation

Portal verification using the KODAK ACR 2000 RT storage phosphor plate system and EC films. A semiquantitative comparison.

Science.gov (United States)

Geyer, Peter; Blank, Hilbert; Alheit, Horst

2006-03-01

The suitability of the storage phosphor plate system ACR 2000 RT (Eastman Kodak Corp., Rochester, MN, USA), that is destined for portal verification as well as for portal simulation imaging in radiotherapy, had to be proven by the comparison with a highly sensitive verification film. The comparison included portal verification images of different regions (head and neck, thorax, abdomen, and pelvis) irradiated with 6- and 15-MV photons and electrons. Each portal verification image was done at the storage screen and the EC film as well, using the EC-L cassettes (both: Eastman Kodak Corp., Rochester, MN, USA) for both systems. The soft-tissue and bony contrast and the brightness were evaluated and compared in a ranking of the two compared images. Different phantoms were irradiated to investigate the high- and low-contrast resolution. To account for quality assurance application, the short-time exposure of the unpacked and irradiated storage screen by green and red room lasers was also investigated. In general, the quality of the processed ACR images was slightly higher than that of the films, mostly due to cases of an insufficient exposure to the film. The storage screen was able to verify electron portals even for low electron energies with only minor photon contamination. The laser lines were sharply and clearly visible on the ACR images. The ACR system may replace the film without any noticeable decrease in image quality thereby reducing processing time and saving the costs of films and avoiding incorrect exposures.

Problems getting from the laboratory to the field: Reclamation of an AML site

International Nuclear Information System (INIS)

Dick, W.A.; Stehouwer, R.C.

1994-01-01

Acid and toxic abandoned mineland sites provide an opportunity whereby flue gas desulfurization (FGD) by-product can be beneficially used as a reclamation amendment material. Studies are needed to compare the effectiveness of FGD by-product, as compared with resoil, for reclamation purposes. Initial studies provided information about the chemical and physical properties of the FGD by-product and how to transport and blend the FGD by-product with yard waste compost. Greenhouse studies indicated that rates of 125 dry tons/acre of FGD and 50 dry tons/acre of yard waste compost would provide optimum results for reclamation of acid and toxic spoil contained at the Fleming abandoned mineland (AML) site. Their results showed that heavy metal loading rates were much lower using the FGD/compost mixture than using resoil material. Dioxin in the mixture was also less than the 5 ppt level considered as normal background. The technical problems of using FGD by-product for reclamation of an AML site were solved. However, considerable efforts to educate the public about the merits of reclaiming the Fleming AML site using this FGD/compost mixture were required before initiating field reclamation activities. Education efforts must continue if FGD by-products are to achieve general acceptance as a reclamation alternative to resoil in cases where resoil is of scarce supply

Primeiro registro de Zaprionus indianus Gupta (Diptera: Drosophilidae no Estado do Acre

Directory of Open Access Journals (Sweden)

Adriana Vasconcelos

2017-04-01

Abstract. This work makes reference to the first record of Zaprionus indianus Gupta (Diptera: Drosophilidae found in carambola fruits (Averrhoa carambola L. in a residential yard located in the county of Rio Branco, Acre, Brazil. The emerged flies were preserved in flasks containing 70% alcohol and identified by the characteristics of the anterior left leg and the male’s genitalia.

Evaluation of habitat restoration needs at Yucca Mountain, Nevada Test Site, Nye County, Nevada

International Nuclear Information System (INIS)

Mitchell, D.L.

1984-04-01

Adverse environmental impacts due to site characterization and repository development activities at Yucca Mountain, Nevada Test Site (NTS), Nye County, Nevada, must be minimized and mitigated according to provisions of the Nuclear Waste Policy Act (NWPA) of 1982 and the National Environmental Policy Act (NEPA). The natural Transition Desert ecosystem in the 27.5-sq-mi Yucca Mountain project area is now and will continue to be impacted by removal of native vegetation and topsoil and the destruction and/or displacement of faunal communities. Although it is not known at this time exactly how much land will be affected, it is estimated that about 300 to 400 acres will be disturbed by construction of facility sites, mining spoils piles, roadways, and drilling pads. Planned habitat restoration at Yucca Mountain will mitigate the effects of plant and animal habitat loss over time by increasing the rate of plant succession on disturbed sites. Restoration program elements should combine the appropriate use of native annual and perennial species, irrigation and/or water-harvesting techniques, and salvage and reuse of topsoil. Although general techniques are well-known, specific program details (i.e., which species to use, methods of site preparation with available equipment, methods of saving and applying topsoil, etc.) must be worked out empirically on a site-specific basis over the period of site characterization and any subsequent repository development. Large-scale demonstration areas set up during site characterization will benefit both present abandonments and, if the project is scaled up to include repository development, larger facilities areas including spoils piles. Site-specific demonstration studies will also provide information on the costs per acre associated with alternative restoration strategies

Quarterly environmental radiological survey summary - first quarter 1997 100, 200, 300, and 600 areas

International Nuclear Information System (INIS)

Mckinney, S.M.

1997-01-01

This report provides a summary of the radiological surveys performed in support of near-facility environmental monitoring at the Hanford Site. The First Quarter 1997 survey results and the status of actions required are summarized below: (1) All of the routine environmental radiological surveys scheduled during January, February, and March 1997, were performed as planned. (2) One hundred four environmental radiological surveys were performed during the first quarter 1997, twenty-nine at the active waste sites and seventy-five at the inactive waste sites. Contamination above background levels was found at eight of the active waste sites and seven of the inactive waste sites. Contamination levels as high as >1,000,000 disintegrations per minute (dpm) were reported. Of these contaminated surveys twelve were in Underground Radioactive Material (URM) areas and three were in contamination areas. The contamination found within ten of the URM areas was immediately cleaned up and no further action was required. In the remaining five sites the areas were posted and will require decontamination. Radiological Problem Reports (RPR's) were issued and the sites were turned over to the landlord for further action if required. (3) During the first quarter of 1997, 5.6 hectares (13.8 acres) were stabilized and radiologically down posted from Contamination Area (CA)/Soil Contamination (SC) to URM. (4) During the first quarter of 1997, the size of 216-A-25 Gable Mountain Pond was increased from 30.4 to 34.5 hectares (75.0 to 85.2 acres). This increase in size was due to the correction of the original boundary area by using the advanced technology of a global positioning system (GPS). An area, 1.6 hectares (4.0 acres), east of and adjacent to the 241-S/SX/SY tank farm complex was posted as a contamination/soil contamination area. (5) Five open Surveillance Compliance Inspection Reports (SCIRs) had not been resolved

Role of the pathotype-specific ACRTS1 gene encoding a hydroxylase involved in the biosynthesis of host-selective ACR-toxin in the rough lemon pathotype of Alternaria alternata.

Science.gov (United States)

Izumi, Yuriko; Kamei, Eri; Miyamoto, Yoko; Ohtani, Kouhei; Masunaka, Akira; Fukumoto, Takeshi; Gomi, Kenji; Tada, Yasuomi; Ichimura, Kazuya; Peever, Tobin L; Akimitsu, Kazuya

2012-08-01

The rough lemon pathotype of Alternaria alternata produces host-selective ACR-toxin and causes Alternaria leaf spot disease of the rootstock species rough lemon (Citrus jambhiri) and Rangpur lime (C. limonia). Genes controlling toxin production were localized to a 1.5-Mb chromosome carrying the ACR-toxin biosynthesis gene cluster (ACRT) in the genome of the rough lemon pathotype. A genomic BAC clone containing a portion of the ACRT cluster was sequenced which allowed identification of three open reading frames present only in the genomes of ACR-toxin producing isolates. We studied the functional role of one of these open reading frames, ACRTS1 encoding a putative hydroxylase, in ACR-toxin production by homologous recombination-mediated gene disruption. There are at least three copies of ACRTS1 gene in the genome and disruption of two copies of this gene significantly reduced ACR-toxin production as well as pathogenicity; however, transcription of ACRTS1 and production of ACR-toxin were not completely eliminated due to remaining functional copies of the gene. RNA-silencing was used to knock down the remaining ACRTS1 transcripts to levels undetectable by reverse transcription-polymerase chain reaction. The silenced transformants did not produce detectable ACR-toxin and were not pathogenic. These results indicate that ACRTS1 is an essential gene in ACR-toxin biosynthesis in the rough lemon pathotype of A. alternata and is required for full virulence of this fungus.

Combinations of mutations in envZ, ftsI, mrdA, acrB and acrR can cause high-level carbapenem resistance in Escherichia coli

DEFF Research Database (Denmark)

Adler, Marlen; Anjum, Mehreen; Andersson, Dan I.

2016-01-01

of meropenem or ertapenem for similar to 60 generations. Isolated clones were whole-genome sequenced, and the order in which the identified mutations arose was determined in the passaged populations. Key mutations were reconstructed, and bacterial growth rates of populations and isolated clones and resistance...... levels to 23 antibiotics were measured. High-level resistance to carbapenems resulted from a combination of downstream effects of envZ mutation and target mutations in AcrAB-TolC-mediated drug export, together with PBP genes [mrdA (PBP2) after meropenem exposure or ftsI (PBP3) after ertapenem exposure...

EnviroAtlas - Acres of crops that have no nearby pollinator habitat for the Conterminous United States

Data.gov (United States)

U.S. Environmental Protection Agency — This dataset is a summary of crop acres without nearby pollinator habitat. Pollination habitat here is defined as trees (fruit, nut, deciduous, and evergreen). Crops...

Design of New Antibacterial Enhancers Based on AcrB’s Structure and the Evaluation of Their Antibacterial Enhancement Activity

Directory of Open Access Journals (Sweden)

Yi Song

2016-11-01

Full Text Available Previously, artesunate (AS and dihydroartemisinine 7 (DHA7 were found to have antibacterial enhancement activity against Escherichia coli via inhibition of the efflux pump AcrB. However, they were only effective against E. coli standard strains. This study aimed to develop effective antibacterial enhancers based on the previous work. Our results demonstrate that 86 new antibacterial enhancers were designed via 3D-SAR and molecular docking. Among them, DHA27 had the best antibacterial enhancement activity. It could potentiate the antibacterial effects of ampicillin against not only E. coli standard strain but also clinical strains, and of β-lactam antibiotics, not non-β-lactamantibiotics. DHA27 could increase the accumulation of daunomycin and nile red within E. coli ATCC 35218, but did not increase the bacterial membrane permeability. DHA27 reduced acrB’s mRNA expression of E. coli ATCC 35218 in a dose-dependent manner, and its antibacterial enhancement activity is related to the degree of acrB mRNA expression in E. coli clinical strains. The polypeptides from AcrB were obtained via molecular docking assay; the pre-incubated polypeptides could inhibit the activity of DHA27. Importantly, DHA27 had no cytotoxicity on cell proliferation. In conclusion, among newly designed antibacterial enhancers, DHA27 had favorable physical and pharmacological properties with no significant cytotoxicity at effective concentrations, and might serve as a potential efflux pump inhibitor in the future.

Environmental assessment of remedial action at the Gunnison Uranium Mill Tailings Site, Gunnison, Colorado. [UMTRA Project

Energy Technology Data Exchange (ETDEWEB)

Bachrach, A.; Hoopes, J.; Morycz, D. (Jacobs Engineering Group, Inc., Pasadena, CA (USA)); Bone, M.; Cox, S.; Jones, D.; Lechel, D.; Meyer, C.; Nelson, M.; Peel, R.; Portillo, R.; Rogers, L.; Taber, B.; Zelle, P. (Weston (Roy F.), Inc., Washington, DC (USA)); Rice, G. (Sergent, Hauskins and Beckwith (USA))

1984-12-01

This document assesses and compares the environmental impacts of various alternatives for remedial action at the Gunnison uranium of mill tailings site located 0.5 miles south of Gunnison, Colorado. The site covers 56 acres and contains 35 acres of tailings, 2 of the original mill buildings and a water tower. The Uranium Mill Tailings Radiation Control of Act of 1978 (UMTRCA), Public Law 95-604, authorizes the US Department of Energy to clean up the site to reduce the potential health impacts associated with the residual radioactive materials remaining at the site and at associated (vicinity) properties off the site. The US Environmental Protection Agency promulgated standards for the remedial actions (40 CFR 192). Remedial actions must be performed in accordance with these standards and with the occurrence of the Nuclear Regulatory Commission. Four alternatives have been addressed in this document. The first alternative is to consolidate the tailings and associated contaminated soils into a recontoured pile on the southern portion of the existing site. A radon barrier of silty clay would be constructed over the pile and various erosion control measures would be taken to assure the long-term integrity of the pile. Two other alternatives which involve moving the tailings to new locations are assessed in this document. These alternatives generally involve greater short-term impacts and are more costly but would result in the tailings being stabilized in a location farther from the city of Gunnison. The no action alternative is also assessed.

Evaluation of native microbial soil populations at a trichloroethylene contaminated Superfund site in the presence of a permeable reactive barrier (biowall) using a metagenomics approach

Science.gov (United States)

The Beaverdam Road Landfill occupies 3.5 acres and was an active disposal site for miscellaneous non-hazardous waste from 1943 to 1990, before being capped. In 1994, this site was included on the Nation Priorities List (NPL) for periodic inspection and remediation in accordance with the program regu...

EL ACRE Y LOS "ASUNTOS DEL PACÍFICO: BOLIVIA, BRASIL, CHILE Y ESTADOS UNIDOS, 1898-1909

Directory of Open Access Journals (Sweden)

Cristián Garay Vera

2008-12-01

Full Text Available Este trabajo sitúa el problema de la guerra del Acre en un contexto multilateral, reconociendo la vigencia del equilibrio de poder como parte del razonamiento de la conducción de las políticas exteriores en juego. Se aplica el concepto de frontera de F. J. Turner, para explicar cómo las fronteras permeables pusieron a Brasil y Bolivia en confrontación, por la maniobra boliviana de configurar una concesión a inversionistas estadounidenses, británicos y franceses, que fue interpretada por Brasil como una maniobra imperialista de Estados Unidos. Entones Brasil se acercó a Chile, y afrontaron juntos los problemas del Acre y de Antofagasta, que derivaron en las redacciones de los tratados de Petrópolis (1903 y de Paz y Amistad (1904. El artículo postula que Bolivia procedió de esta forma para impedir el avance brasileño, peruano y paraguayo sobre sus fronteras, y que la búsqueda del paraguas estadounidense fue una idea que Bolivia gestó para compensar el desequilibrio de poder.This work considers the Acre War as part of a multilateral context where the equilibrium of power was important in the reasoning behind the establishment of foreign relations. It uses the frontier concept developed by F. J. Turner to explain why their open frontier put Brazil and Bolivia in confrontation. This happened because of the Bolivian strategy of granting land to investors from the United States, Great Britain and France, which was interpreted by Brazil as an imperialist action promoted by the United States. This explains why Brazil established a cióse relationship with Chile to confront together their problems in Acre and Antofagasta, which led to the drafting of the Petrópilis (1903 and Paz y Amistad (1904 treaties. The article argues that Bolivia proceeded this way to avoid a Brazilian, Peruvian or Paraguayan territorial advance, seeking the support of the United States to compénsate the imbalance of power.

Seventy Years of the EPR Paradox

Science.gov (United States)

Kupczynski, Marian

2006-11-01

In spite of the fact that statistical predictions of quantum theory (QT) can only be tested if large amount of data is available a claim has been made that QT provides the most complete description of an individual physical system. Einstein's opposition to this claim and the paradox he presented in the article written together with Podolsky and Rosen in 1935 inspired generations of physicists in their quest for better understanding of QT. Seventy years after EPR article it is clear that without deep understanding of the character and limitations of QT one may not hope to find a meaningful unified theory of all physical interactions, manipulate qubits or construct a quantum computer.. In this paper we present shortly the EPR paper, the discussion, which followed it and Bell inequalities (BI). To avoid various paradoxes we advocate purely statistical contextual interpretation (PSC) of QT. According to PSC a state vector is not an attribute of a single electron, photon, trapped ion or quantum dot. A value of an observable assigned to a physical system has only a meaning in a context of a particular physical experiment PSC does not provide any mental space-time picture of sub phenomena. The EPR paradox is avoided because the reduction of the state vector in the measurement process is a passage from a description of the whole ensemble of the experimental results to a particular sub-ensemble of these results. We show that the violation of BI is neither a proof of the completeness of QT nor of its non-locality. Therefore we rephrase the EPR question and ask whether QT is "predictably "complete or in other words does it provide the complete description of experimental data. To test the "predictable completeness" it is not necessary to perform additional experiments it is sufficient to analyze more in detail the existing experimental data by using various non-parametric purity tests and other specific statistical tools invented to study the fine structure the time-series.

Test program for closure activities at a mixed waste disposal site at the Savannah River Plant

International Nuclear Information System (INIS)

Cook, J.R.; Harley, J.P. Jr.

1988-01-01

A 58-acre site at the Savannah River Plant which was used for disposal of low-level radioactive waste and quantities of the hazardous materials lead, cadmium, scintillation fluid, and oil will be the first large waste site at the Savannah River Plant to be permanently closed. The actions leading to closure of the facility will include surface stabilization and capping of the site. Test programs have been conducted to evaluate the effectiveness of dynamic compaction as a stabilization technique and the feasibility of using locally derived clay as a capping material

Conceptual design report, TWRS Privatization Phase I, site development and roads, subproject W-505

International Nuclear Information System (INIS)

Singh, G.

1997-01-01

This document includes Conceptual Design Report (CDR) for the site development, construction of new roads and improvements at existing road intersections, habitat mitigation, roadway lighting, and construction power needed for the construction of two Private Contractor (PC) Facilities. Approximately 50 hectare (124 acres) land parcel, east of the Grout Facility, is planned for the PC facilities

At Home in Space The Late Seventies into the Eighties

CERN Document Server

Evans, Ben

2012-01-01

April 12, 2011, is the 50th anniversary of Yuri Gagarin's pioneering journey into space. To commemorate this momentous achievement, Springer-Praxis is producing a mini series of books that reveals how humanity's knowledge of flying, working, and living in space has grown in the last half century. At Home in Space, the third book in the series, continues the story throughout the later Seventies and into the Eighties. It was a period of time characterised by great promise. Regular Soviet missions demonstrated that humanity could not only survive, but thrive, in a weightless environment, and the arrival of the Space Shuttle seemed to offer a more economical and routine means of accessing the heavens. Living in space became truly international as astronauts from many nations lived and worked together on Soviet space stations and aboard the Shuttle. At the same time, however, relations between two key players in this drive to conquer the high ground of space - the United States and the Soviet Union - steadily decl...

Environmental Assessment of remedial action at the Ambrosia Lake uranium mill tailings site, Ambrosia Lake, New Mexico

Energy Technology Data Exchange (ETDEWEB)

1987-06-01

This document assesses and compares the environmental impacts of various alternatives for remedial action at the Ambrosia Lake uranium mill tailings site located near Ambrosia Lake, New Mexico. The designated site covers 196 acres and contains 111 acres of tailings and some of the original mill structures. The Uranium Mill Tailings Radiation Control Act (UMTRCA), Public Law 95-604, authorizes the US Department of Energy to clean up the site to reduce the potential health impacts associated with the residual radioactive materials remaining at the site and at associated properties off the site. The US Environmental Protection Agency promulgated standards for th remedial action (40 CFR Part 192). Remedial action must be performed in accordance with these standards and with the concurrence of the Nuclear Regulatory Commission. The proposed action is to stabilize the tailings at their present location by consolidating the tailings and associated contaminated materials into a recontoured pile. A radon barrier would be constructed over the pile and various erosion protection measures would be taken to assure the long-term stability of the pile. Another alternative which would involve moving the tailings to a new location is also assessed in this document. This alternative would generally involve greater short-term impacts and costs but would result in stabilization of the tailings at an undeveloped location. The no action alternative is also assessed in this document.

Environmental Assessment of remedial action at the Ambrosia Lake uranium mill tailings site, Ambrosia Lake, New Mexico

International Nuclear Information System (INIS)

1987-06-01

This document assesses and compares the environmental impacts of various alternatives for remedial action at the Ambrosia Lake uranium mill tailings site located near Ambrosia Lake, New Mexico. The designated site covers 196 acres and contains 111 acres of tailings and some of the original mill structures. The Uranium Mill Tailings Radiation Control Act (UMTRCA), Public Law 95-604, authorizes the US Department of Energy to clean up the site to reduce the potential health impacts associated with the residual radioactive materials remaining at the site and at associated properties off the site. The US Environmental Protection Agency promulgated standards for th remedial action (40 CFR Part 192). Remedial action must be performed in accordance with these standards and with the concurrence of the Nuclear Regulatory Commission. The proposed action is to stabilize the tailings at their present location by consolidating the tailings and associated contaminated materials into a recontoured pile. A radon barrier would be constructed over the pile and various erosion protection measures would be taken to assure the long-term stability of the pile. Another alternative which would involve moving the tailings to a new location is also assessed in this document. This alternative would generally involve greater short-term impacts and costs but would result in stabilization of the tailings at an undeveloped location. The no action alternative is also assessed in this document

Trypanosoma sp. diversity in Amazonian bats (Chiroptera; Mammalia) from Acre State, Brazil.

Science.gov (United States)

Dos Santos, Francisco C B; Lisboa, Cristiane V; Xavier, Samanta C C; Dario, Maria A; Verde, Rair de S; Calouro, Armando M; Roque, André Luiz R; Jansen, Ana M

2017-11-16

Bats are ancient hosts of Trypanosoma species and their flying ability, longevity and adaptability to distinct environments indicate that they are efficient dispersers of parasites. Bats from Acre state (Amazon Biome) were collected in four expeditions conducted in an urban forest (Parque Zoobotânico) and one relatively more preserved area (Seringal Cahoeira) in Rio Branco and Xapuri municipalities. Trypanosoma sp. infection was detected by hemoculture and fresh blood examination. Isolated parasite species were identified by the similarity of the obtained DNA sequence from 18S rDNA polymerase chain reaction and reference strains. Overall, 367 bats from 23 genera and 32 species were examined. Chiropterofauna composition was specific to each municipality, although Artibeus sp. and Carollia sp. prevailed throughout. Trypanosoma sp. infection was detected in 85 bats (23·2%). The most widely distributed and prevalent genotypes were (in order) Trypanosoma cruzi TcI, T. cruzi marinkellei, Trypanosoma dionisii, T. cruzi TcIV and Trypanosoma rangeli. At least one still-undescribed Trypanosoma species was also detected in this study. The detection of T. cruzi TcI and TcIV (the ones associated with Chagas disease in Amazon biome) demonstrates the putative importance of these mammal hosts in the epidemiology of the disease in the Acre State.

Comparative analysis of the 2016 ACR-EULAR and the 2002 AECG classification criteria for Sjögren's syndrome: Findings from the NIH cohort.

Science.gov (United States)

Billings, M; Amin Hadavand, M; Alevizos, I

2018-03-01

The introduction of new classification criteria for Sjögren's syndrome, known as the 2016 American College of Rheumatology/European League against Rheumatism Classification Criteria (ACR-EULAR), created a need for the evaluation of its performance in an external cohort. The purpose of this study was to compare the performance of the 2016 ACR-EULAR classification set with the widely used American-European Consensus Group Classification criteria (AECG) in the cohort at the National Institutes of Health, USA, and to compare the performance of the sets in classifying both primary and secondary Sjögren's syndrome (pSS and sSS). The study cohort at the NIH (N = 1,303) was enrolled for clinical suspicion of SS. Participants were classified as SS, pSS, and sSS according to both classification sets. Performance of 2016 ACR-EULAR and AECG sets was compared holding each as gold standard to the other. Statistical analysis of test diagnostics and agreement between the two sets were undertaken. By the AECG set, 701 were classified as having SS (627 pSS, 74 sSS) and 714 were classified with SS (647 pSS, 67 sSS) by the 2016 ACR-EULAR set. Sensitivity and specificity of the two sets were comparable in classifying SS, pSS, and sSS. There was high agreement between the two sets for classifying SS (κ = 0.79), pSS (κ = 0.81), and sSS (κ = 0.87). The specificity of the 2016 ACR-EULAR set was significantly higher for classifying sSS than pSS, while the sensitivity was similar for the two disease groups. However, this pattern was also exhibited by the AECG set. There was high agreement between the two classification sets with comparable performance diagnostics. There was no evidence of superior performance value by the new 2016 ACR-EULAR set over the AECG set, and the two sets were found to be equivalent. Findings from our cohort indicate that 2016 ACR-EULAR classification could be extended to classification of sSS. Published 2018. This article is a U.S. Government work and

Joint involvement in patients with early polymyalgia rheumatica using high-resolution ultrasound and its contribution to the EULAR/ACR 2012 classification criteria for polymyalgia rheumatica.

Science.gov (United States)

Weigand, Sandra; Ehrenstein, Boris; Fleck, Martin; Hartung, Wolfgang

2014-04-01

To assess joint involvement and the contribution of musculoskeletal ultrasound (MSUS) to the novel European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) 2012 classification criteria in patients with polymyalgia rheumatic (PMR). MSUS was performed in 54 consecutive patients with recent-onset PMR. Biceps tenosynovitis of at least 1 shoulder has been observed in 70.4% of patients, and 64.8% had a bilateral biceps tenosynovitis. Subdeltoid bursitis (27.8% unilateral, 5.6% bilateral), glenohumeral synovitis (22.2% unilateral, 9.3% bilateral), and hip involvement (22.2% unilateral, 16.7% bilateral) were observed less frequently. The sensitivities of the classification criteria were 85.2% for EULAR/ACR without MSUS and 81.5% for EULAR/ACR with MSUS. The most common MSUS pathology was a biceps tenosynovitis. However, US findings had no effect on the sensitivity of the novel EULAR/ACR criteria for PMR.

Reconnaissance survey of site 7 of the proposed Three Rivers Regional Landfill and Technology Center, Savannah River Site, Aiken County, South Carolina

Energy Technology Data Exchange (ETDEWEB)

Cabak, M.A.; Beck, M.L.; Gillam, C.; Sassaman, K.E.

1996-02-01

This report documents the archaeological investigation of Site 7 of the proposed Three Rivers Regional Landfill and Technology Center in Aiken County on the United States Department of Energy`s Savannah River Site (SRS) in Aiken and Barnwell Counties, South Carolina. Pedestrian and subsurface survey techniques were used to investigate the 1,403-acre project area. Survey resulted in the discovery of 23 previously unrecorded sites and 11 occurrences; six previously recorded sites were also investigated. These sites consist of six prehistoric sites, nine historic sites, and 14 sites with both prehistoric and historic components. Sites locations and project area boundaries are provided on a facsimile of a USGS 7.5 topographic map. The prehistoric components consist of very small, low-density lithic and ceramic scatters; most contain less than 10 artifacts. Six of the prehistoric components are of unknown cultural affiliation, the remaining prehistoric sites were occupied predominately in the Woodland period. The historic sites are dominated by postbellum/modem home places of tenant and yeoman farmers but four historic sites were locations of antebellum house sites (38AK136, 38AK613, 38AK660, and 38AK674). The historic sites also include an African-American school (38AK677).

First record of Ceratitis capitata (Wiedemann (Diptera: Tephritidae in the state of Acre, Brazil

Directory of Open Access Journals (Sweden)

Ricardo Adaime

2017-12-01

Resumo. Registra-se pela primeira vez a presença de Ceratitis capitata (Wiedemann (Diptera: Tephritidae no estado do Acre, Brasil, a partir de frutos de goiabeira (Psidium guajava L. e de caramboleira (Averrhoacarambola L., aumentando o conhecimento dos registros geográficos dessa mosca na Amazônia brasileira.

Portal verification using the KODAK ACR 2000 RT storage phosphor plate system and EC registered films. A semiquantitative comparison

International Nuclear Information System (INIS)

Geyer, P.; Blank, H.; Alheit, H.

2006-01-01

Background and Purpose: the suitability of the storage phosphor plate system ACR 2000 RT (Eastman Kodak Corp., Rochester, MN, USA), that is destined for portal verification as well as for portal simulation imaging in radiotherapy, had to be proven by the comparison with a highly sensitive verification film. Material and Methods: the comparison included portal verification images of different regions (head and neck, thorax, abdomen, and pelvis) irradiated with 6- and 15-MV photons and electrons. Each portal verification image was done at the storage screen and the EC registered film as well, using the EC-L registered cassettes (both: Eastman Kodak Corp., Rochester, MN, USA) for both systems. The soft-tissue and bony contrast and the brightness were evaluated and compared in a ranking of the two compared images. Different phantoms were irradiated to investigate the high- and low-contrast resolution. To account for quality assurance application, the short-time exposure of the unpacked and irradiated storage screen by green and red room lasers was also investigated. Results: in general, the quality of the processed ACR images was slightly higher than that of the films, mostly due to cases of an insufficient exposure to the film. The storage screen was able to verify electron portals even for low electron energies with only minor photon contamination. The laser lines were sharply and clearly visible on the ACR images. Conclusion: the ACR system may replace the film without any noticeable decrease in image quality thereby reducing processing time and saving the costs of films and avoiding incorrect exposures. (orig.)

Avaliação da concentração de mercúrio em sedimentos e material particulado no rio Acre, estado do Acre, Brasil Mercury concentration assessment in botton sediments and suspended solids from Acre river, in the State of Acre, Brazil

Directory of Open Access Journals (Sweden)

Artur Fernando Silva Mascarenhas

2004-01-01

Full Text Available A avaliação dos teores de mercúrio em sistemas aquáticos sem influência direta de fontes antropogênicas conhecidas não tem sido conduzida com freqüência na região Amazônica. Visando contribuir para esclarecer a ocorrência de valores elevados de Hg em peixes consumidos pela população de Rio Branco - AC, o Instituto Evandro Chagas - IEC, realizou um estudo para quantificar os teores de Hg em sedimentos de fundo e material particulado no rio Acre e alguns afluentes, além da caracterização físico-química das águas entre as cidades de Brasiléia e Assis Brasil. As amostras de sedimentos foram peneiradas na fração Mercury levels assessment in aquatic systems areas without influences of antropogenic sources have not been well studied in the Amazon region. For the identification of the origin of high values of Hg in fish consumed by population of Rio Branco City - AC, the Evandro Chagas Institute - IEC, studied the mercury levels in sediments, suspended solids and studied also the physical-chemical characterization of waters, in the Acre river and also some in afluents, between Brasiléia and Assis Brasil cities. Bottom sediments samples were sieved to <250 mesh fraction after drying. The suspended solid was obtained by precipitation with Al2SO4. About 250 mg of the material was submitted the acid digestion and the determinations of Hg were made by Could Vapor Atomic Absorption Spectrometry. The physical-chemical parameters pH, electric conductivity, temperature and dissolved total solids, were studied in the field, by potenciometric methods. The Hg levels in bottom sediments range 0,018 and 0,184 mug g-1, mean of 0,054 ± 0,034 mug g-1, while the suspended solids varied between 0,067 and 0,220 mug g-1, average of 0,098 ± 0,037 mug g-1. The waters were slightly acid with pH varying among 5,80 - 6,95 and conductivity electric 151,60 - 1.151,00 muS cm-1. The mercury levels in the analyzed materials was below of standard levels for

Remedial actions at the former Vitro Rare Metals plant site, Canonsburg, Washington County, Pennsylvania. Final Environmental Impact Statement. Volume I

Energy Technology Data Exchange (ETDEWEB)

1983-07-01

The environmental impacts associated with remedial actions in connection with residual radioactive materials remaining at the inactive uranium processing site located in Canonsburg, Washington County, Pennsylvania are evaluated. The Canonsburg site is an 18.5-acre property that was formerly owned by the Vitro Rare Metals Company. The expanded Canonsburg site would be 30-acre property that would include the Canonsburg site (the former Vitro Rare Metals plant), seven adjacent private houses, and the former Georges Pottery property. During the period 1942 through 1957 the Vitro Manufacturing Company and its successor, the Vitro Corporation of America, processed onsite residues and ores, and government-owned ores, concentrates, and scraps to extract uranium and other rare metals. The Canonsburg site is now the Canon Industrial Park. In addition to storing the residual radioactive materials of this process at the Canonsburg site, about 12,000 tons of radioactively contaminated materials were transferred to a railroad landfill in Burrell Township, Indiana County, Pennsylvania. This Canonsburg FEIS evaluates five alternatives for removing the potential public health hazard associated with the radioactively contaminated materials. In addition to no action, these alternatives involve various combinations of stabilization of the radioactively contaminated materials in place or decontamination of the Canonsburg and Burrell sites by removing the radioactively contaminated materials to another location. In addition to the two sites mentioned, a third site located in Hanover Township, Washington County, Pennsylvania has been considered as a disposal site to which the radioactively contaminated materials presently located at either of the other two sites might be moved.

Remedial actions at the former Vitro Rare Metals plant site, Canonsburg, Washington County, Pennsylvania. Final Environmental Impact Statement. Volume I

International Nuclear Information System (INIS)

1983-07-01

The environmental impacts associated with remedial actions in connection with residual radioactive materials remaining at the inactive uranium processing site located in Canonsburg, Washington County, Pennsylvania are evaluated. The Canonsburg site is an 18.5-acre property that was formerly owned by the Vitro Rare Metals Company. The expanded Canonsburg site would be 30-acre property that would include the Canonsburg site (the former Vitro Rare Metals plant), seven adjacent private houses, and the former Georges Pottery property. During the period 1942 through 1957 the Vitro Manufacturing Company and its successor, the Vitro Corporation of America, processed onsite residues and ores, and government-owned ores, concentrates, and scraps to extract uranium and other rare metals. The Canonsburg site is now the Canon Industrial Park. In addition to storing the residual radioactive materials of this process at the Canonsburg site, about 12,000 tons of radioactively contaminated materials were transferred to a railroad landfill in Burrell Township, Indiana County, Pennsylvania. This Canonsburg FEIS evaluates five alternatives for removing the potential public health hazard associated with the radioactively contaminated materials. In addition to no action, these alternatives involve various combinations of stabilization of the radioactively contaminated materials in place or decontamination of the Canonsburg and Burrell sites by removing the radioactively contaminated materials to another location. In addition to the two sites mentioned, a third site located in Hanover Township, Washington County, Pennsylvania has been considered as a disposal site to which the radioactively contaminated materials presently located at either of the other two sites might be moved

Environmental assessment of remedial action at the Tuba City uranium mill tailings site, Tuba City, Arizona

Energy Technology Data Exchange (ETDEWEB)

None

1986-11-01

This document assesses and compares the environmental impacts of various alternatives for remedial action at the Tuba City uranium mill tailings site located approximately six miles east of Tuba City, Arizona. The site covers 105 acres and contains 25 acres of tailings and some of the original mill structures. The Uranium Mill Tailings Radiation Control Act of 1978 (UMTRCA), Public Law 95-604, authorizes the US Department of Energy to clean up the site to reduce the potential health impacts associated with the residual radioactive materials remaining at the site and at associated properties off the site. The US Environmental Protection Agency promulgated standards for the remedial actions (40 CFR Part 192). Remedial actions must be performed in accordance with these standards and with the concurrence of the Nuclear Regulatory Commission. The proposed action is to stabilize the tailings at their present location by consolidating the tailings and associated contaminated materials into a recontoured pile. A radon barrier would be constructed over the pile and various erosion control measures would be taken to assure the long-term stability of the pile. Another alternative which would involve moving the tailings to a new location is also assessed in this document. This alternative would generally involve greater short-term impacts and costs but would result in stabilization of the tailings at a more remote location. The no action alternative is also assessed in this document.

Environmental assessment of remedial action at the Tuba City uranium mill tailings site, Tuba City, Arizona

International Nuclear Information System (INIS)

1986-11-01

This document assesses and compares the environmental impacts of various alternatives for remedial action at the Tuba City uranium mill tailings site located approximately six miles east of Tuba City, Arizona. The site covers 105 acres and contains 25 acres of tailings and some of the original mill structures. The Uranium Mill Tailings Radiation Control Act of 1978 (UMTRCA), Public Law 95-604, authorizes the US Department of Energy to clean up the site to reduce the potential health impacts associated with the residual radioactive materials remaining at the site and at associated properties off the site. The US Environmental Protection Agency promulgated standards for the remedial actions (40 CFR Part 192). Remedial actions must be performed in accordance with these standards and with the concurrence of the Nuclear Regulatory Commission. The proposed action is to stabilize the tailings at their present location by consolidating the tailings and associated contaminated materials into a recontoured pile. A radon barrier would be constructed over the pile and various erosion control measures would be taken to assure the long-term stability of the pile. Another alternative which would involve moving the tailings to a new location is also assessed in this document. This alternative would generally involve greater short-term impacts and costs but would result in stabilization of the tailings at a more remote location. The no action alternative is also assessed in this document

Site Environmental Report for 2011, Volumes 1& 2

Energy Technology Data Exchange (ETDEWEB)

Baskin, David; Bauters, Tim; Borglin, Ned; Fox, Robert; Horst, Blair; Jelinski, John; Lackner, Ginny; Philliber, Jeff; Rothermich, Nancy; Thorson, Patrick; Wahl, Linnea; Xu, Suying

2012-09-12

The Site Environmental Report for 2011 summarizes Berkeley Lab’s environmental management performance, presents environmental monitoring results, and describes significant programs for calendar year (CY) 2011. Throughout this report, “Berkeley Lab” or “LBNL” refers both to (1) the multiprogram scientific facility the UC manages and operates on the 202-acre university-owned site located in the hills above the UC Berkeley campus, and the site itself, and (2) the UC as managing and operating contractor for Ernest Orlando Lawrence Berkeley National Laboratory. The report is separated into two volumes. Volume I is organized into an executive summary followed by six chapters that include an overview of LBNL, a discussion of its Environmental Management System (EMS), the status of environmental programs, summarized results from surveillance and monitoring activities, and quality assurance (QA) measures. Volume II contains individual data results from surveillance and monitoring activities.

Evaluation of a series of 2-napthamide derivatives as inhibitors of the drug efflux pump AcrB for the reversal of antimicrobial resistance.

Science.gov (United States)

Wang, Yinhu; Mowla, Rumana; Guo, Liwei; Ogunniyi, Abiodun D; Rahman, Taufiq; De Barros Lopes, Miguel A; Ma, Shutao; Venter, Henrietta

2017-02-15

Drug efflux pumps confer multidrug resistance to dangerous pathogens which makes these pumps important drug targets. We have synthesised a novel series of compounds based on a 2-naphthamide pharmacore aimed at inhibiting the efflux pumps from Gram-negative bacteria. The archeatypical transporter AcrB from Escherichia coli was used as model efflux pump as AcrB is widely conserved throughout Gram-negative organisms. The compounds were tested for their antibacterial action, ability to potentiate the action of antibiotics and for their ability to inhibit Nile Red efflux by AcrB. None of the compounds were antimicrobial against E. coli wild type cells. Most of the compounds were able to inhibit Nile Red efflux indicating that they are substrates of the AcrB efflux pump. Three compounds were able to synergise with antibiotics and reverse resistance in the resistant phenotype. Compound A3, 4-(isopentyloxy)-2-naphthamide, reduced the MICs of erythromycin and chloramphenicol to the MIC levels of the drug sensitive strain that lacks an efflux pump. A3 had no effect on the MIC of the non-substrate rifampicin indicating that this compound acts specifically through the AcrB efflux pump. A3 also does not act through non-specific mechanisms such as outer membrane or inner membrane permeabilisation and is not cytotoxic against mammalian cell lines. Therefore, we have designed and synthesised a novel chemical compound with great potential to further optimisation as inhibitor of drug efflux pumps. Copyright © 2017 Elsevier Ltd. All rights reserved.

Modelling of liquid injection shutdown system (LISS) in ACR-1000

International Nuclear Information System (INIS)

Boubcher, M.; Colton, A.; Donnelly, J.V.

2008-01-01

Modelling of the Liquid Injection Shutdown System (LISS) in the ACR-1000 reactor core must account for the major phenomena that occur following its activation, namely the moderator hydraulics and core neutronics. The former requires modelling of the poison volumes, their time of entry into the reactor, and their propagation into the moderator after emission from the nozzle. The latter requires the reactivity worth of varying volumes and geometries of poisoned moderator fluid in order to simulate the reactivity effect of the injected poison. The time-dependent poison map is generated from hydraulic calculations, and then the neutronics data for standard geometries and concentrations is constructed using DRAGON. (author)

Ecological assessments at DOE hazardous waste sites: Current procedures and problems

International Nuclear Information System (INIS)

Hlohowskyj, I.; Krummel, J.R.; Irving, J.S.; Vinikour, W.S.

1989-01-01

Major actions at US Department of Energy (DOE) hazardous waste sites require CERCLA compliance that meets NEPA considerations. Although NEPA compliance includes ecological considerations, neither the Council on Environmental Quality (CEQ) nor the DOE provide detailed guidance for conducting ecological assessments under NEPA. However, the identification of the form and magnitude of potential ecological impacts associated with a proposed action is directly dependent on the quality of the baseline data available for a particular site. Using the Surplus Facilities Management Program Weldon Spring site as an example, we discuss the collection of baseline ecological data for the site. This site is surrounded by approximately 17,000 acres of wildlife area. Available wildlife data consisted of qualitative, county-level species lists, and vegetation data was in the form of a regional qualitative narrative. Detailed site-specific occurrence data for listed species and high quality natural communities was provided by the Missouri Department of Conservation Heritage data base. 30 refs., 1 fig., 1 tab

Superfund Record of Decision (EPA Region 5): Buckeye Reclamation Landfill Site, Belmont County, OH. (First remedial action), August 1991. Final report

International Nuclear Information System (INIS)

1991-01-01

The 658-acre Buckeye Reclamation site contains a 50-acre former landfill in Richland Township, Belmont County, Ohio. Land use in the area is predominantly agricultural, rural residential, and strip mining. A total of 46 domestic wells and springs are located within 1 mile of the site. The original topography of the valley has been altered by coal mining and landfill operations. Solid industrial wastes also were disposed of with municipal wastes elsewhere in the landfill. In 1980, the Waste Pit was filled with sludge, mine spoil, and overburden soil; covered with soil and garbage; and seeded. Results of the RI indicate various levels of contamination in all media sampled, except air. The Record of Decision (ROD) addresses the remediation of contaminated leachate and ground water and eliminates exposure to contaminated surface soil. The primary contaminants of concern affecting the soil and ground water are VOCs including benzene, TCE, and toluene; other organics including PAHs; and metals including arsenic, chromium, beryllium, and lead. The selected remedial action for the site is included

Antibacterial Efficacy of Polysaccharide Capped Silver Nanoparticles Is Not Compromised by AcrAB-TolC Efflux Pump

Directory of Open Access Journals (Sweden)

Mitali Mishra

2018-05-01

Full Text Available Antibacterial therapy is of paramount importance in treatment of several acute and chronic infectious diseases caused by pathogens. Over the years extensive use and misuse of antimicrobial agents has led to emergence of multidrug resistant (MDR and extensive drug resistant (XDR pathogens. This drastic escalation in resistant phenotype has limited the efficacy of available therapeutic options. Thus, the need of the hour is to look for alternative therapeutic approaches to mitigate healthcare concerns caused due to MDR bacterial infections. Nanoparticles have gathered much attention as potential candidates for antibacterial therapy. Equipped with advantages of, wide spectrum bactericidal activity at very low dosage, inhibitor of biofilm formation and ease of permeability, nanoparticles have been considered as leading therapeutic candidates to curtail infections resulting from MDR bacteria. However, substrate non-specificity of efflux pumps, particularly those belonging to resistance nodulation division super family, have been reported to reduce efficacy of many potent antibacterial therapeutic drugs. Previously, we had reported antibacterial activity of polysaccharide-capped silver nanoparticles (AgNPs toward MDR bacteria. We showed that AgNPs inhibits biofilm formation and alters expression of cytoskeletal proteins FtsZ and FtsA, with minimal cytotoxicity toward mammalian cells. In the present study, we report no reduction in antibacterial efficacy of silver nanoparticles in presence of AcrAB-TolC efflux pump proteins. Antibacterial tests were performed according to CLSI macrobroth dilution method, which revealed that both silver nanoparticles exhibited bactericidal activity at very low concentrations. Further, immunoblotting results indicated that both the nanoparticles modulate the transporter AcrB protein expression. However, expression of the membrane fusion protein AcrA did show a significant increase after exposure to AgNPs. Our results

Formerly utilized MED/AEC Sites Remedial Action Program. Radiological survey of the Pennsylvania Railroad Landfill Site, Burrell Township, Pennsylvnia. Final Report

International Nuclear Information System (INIS)

1979-02-01

A radiological survey was conducted at the Pennsylvania Railroad Landfill Site in Burrell Township, Pennsylvania. In 1956 and 1957, approximately 11,600 tons of radioactive material was dumped at this site and was apparently scattered over an area of loss than 10 acres. The survey included measurement of the following: external gamma radiation at 1 m above the surface and at the surface throughout the site; beta--gamma dose rates at 1 cm from the surface throughout the site; concentrations of 226 Ra and 238 U in surface and subsurface soil on the site; concentrations of 210 Pb, 226 Ra, 230 Th, and 238 U in subsurface water on the site and in surface water on and near the site; and the extent of atmospheric transport of 222 Rn and progeny from the site. The general location of the residues transported to the site, except possibly small, scattered quantities of materials, was determined from the survey. In some areas on the site, beta--gamma dose rates of 1 cm from the surface were above pertinent guidelines.Analyses of sediment from water samples taken from drainage areas near the site indicate that some radioactive material is being carried from the site by surface run-off. Results of this survey indicate that there is no significant atmospheric transport of 222 Rn from the site

Proceedings of the symposium on quantum- and opto-electronics, Bombay, India, February 25--28, 1974. [Seventy-two papers

Energy Technology Data Exchange (ETDEWEB)

1974-01-01

Seventy-two papers are presented on quantum and optical electronics, with the majority of the papers dealing with lasers or laser applications. Some of the topics discussed include laser materials, spectroscopy, laser tuning and focusing, optical theory, holography, interferometry, and optical properties of solids. (PMA)

Exile and insile: split subject policies and representations in chilean poetry of the seventies

Directory of Open Access Journals (Sweden)

Naín Nómez

2010-07-01

Full Text Available This article is an inventory and analysis of Chilean Poetry in the seventies, written in Chileand abroad, emphasizing the "exilio" and "insilio" concept. Apart from focusing on the "exilio-insilio" problem, its development and subsequent integration, this work analyzes the relationships between poets and their enviroment by means of subjective representations in different situations and places (especially urban. The cities of Chile, as well as foreign cities in the countries of exile, acquire repressive connotations, which influence the problems of the divided subject in this poetry.

Overview of Nevada Test Site Radioactive and Mixed Waste Disposal Operations

International Nuclear Information System (INIS)

Carilli, J.T.; Krenzien, S.K.; Geisinger, R.G.; Gordon, S.J.; Quinn, B.

2009-01-01

The U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office Environmental Management Program is responsible for carrying out the disposal of on-site and off-site generated low-level radioactive waste (LLW) and low-level radioactive mixed waste (MW) at the Nevada Test Site (NTS). Core elements of this mission are ensuring safe and cost-effective disposal while protecting workers, the public, and the environment. This paper focuses on the impacts of new policies, processes, and opportunities at the NTS related to LLW and MW. Covered topics include: the first year of direct funding for NTS waste disposal operations; zero tolerance policy for non-compliant packages; the suspension of mixed waste disposal; waste acceptance changes; DOE Consolidated Audit Program (DOECAP) auditing; the 92-Acre Area closure plan; new eligibility requirements for generators; and operational successes with unusual waste streams

ACR Appropriateness Criteria® Tinnitus.

Science.gov (United States)

Kessler, Marcus M; Moussa, Marwan; Bykowski, Julie; Kirsch, Claudia F E; Aulino, Joseph M; Berger, Kevin L; Choudhri, Asim F; Fife, Terry D; Germano, Isabelle M; Kendi, A Tuba; Kim, Jeffrey H; Luttrull, Michael D; Nunez, Diego; Shah, Lubdha M; Sharma, Aseem; Shetty, Vilaas S; Symko, Sophia C; Cornelius, Rebecca S

2017-11-01

Tinnitus is the perception of sound in the absence of an external source. It is a common symptom that can be related to hearing loss and other benign causes. However, tinnitus may be disabling and can be the only symptom in a patient with a central nervous system process disorder. History and physical examination are crucial first steps to determine the need for imaging. CT and MRI are useful in the setting of pulsatile tinnitus to evaluate for an underlying vascular anomaly or abnormality. If there is concomitant asymmetric hearing loss, neurologic deficit, or head trauma, imaging should be guided by those respective ACR Appropriateness Criteria ® documents, rather than the presence of tinnitus. Imaging is not usually appropriate in the evaluation of subjective, nonpulsatile tinnitus that does not localize to one ear. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment. Copyright © 2017 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Effect of multicell DRAGON calculations depends on the environment on the DONJON predictions for the ACR-1000

International Nuclear Information System (INIS)

Duquette, J.-S.

2009-01-01

For understanding the behavior of a nuclear reactor core, it is necessary to make a full core calculation in order to compute the neutrons flux. To obtain the neutrons flux, solving the Boltzmann transport equation is required. That is not a simple task and it is impossible to analytically fend the solution of the neutrons transport equation on a complex core. Following a series of approximations, it is possible to numerically solve the neutrons transport equation. The solution of this equation is done step by step. Calculations will be performed over the ACR-1000 core. The Advanced CANDU Reactor (ACR-1000) is a generation III+ heavy water moderated and light water cooled reactor. It is a 1200 MW(e) power reactor. Amongst the ACR-1000 design parameters that differ from the CANDU 6, the reduced lattice pitch and the use of light water coolant and enriched fuel are the three most important. Those features modify the behavior of the neutrons in the ACR compared to the CANDU 6. The impact of the tight lattice is that a cell is more strongly coupled to its neighbor. The objective of this work is to determine the impact of the environment on the cell properties of the ACR-1000. Those properties will be used to perform full core calculations. The neutron transport calculations are performed with DRAGON whereas for the diffusion calculation on a full core. The code DONJON will be used. The DRAGON reference transport calculation will be made on a single cell. Then, a series of calculations will be performed using DRAGON over two types of assemblies, the first modelling the core interior and the second, modelling the core periphery. Moreover, the fuel age will sometimes be homogeneous, sometimes heterogeneous. The fuel will be burned during six hundred days. One thus obtains libraries of macroscopic cross sections over a six hundred days interval for various simulations. Thereafter, we will determine the effect of a neutrons transport multicell calculation on various DONJON

MCNP Simulations of End Flux Peaking in ACR-1000, 2.4 wt % {sup 235}U Fuel Bundles

Energy Technology Data Exchange (ETDEWEB)

Hill, Ian; Donnelly, Jim [Atomic Energy of Canada Limited (AECL), 2251 Speakman Drive, Mississauga, ON, L5K 1B2 (Canada)

2008-07-01

This paper examines the end flux peaking in ACR-1000 fuel bundles. Reactor physics simulations are performed with MCNP to assess the steady state end-flux peaking in an infinite lattice of ACR fuel, as well as to quantify the peaking that occurs during refuelling. 3-dimensional MCNP models are created based on the detailed geometry of the fuel bundle. Detailed position-dependent fuel compositions are obtained from MONTEBURNS which couples MCNP and ORIGIN2.2. Axial and radial power profiles are obtained for both fresh and mid-burnup fuel bundles in an infinite lattice. Subsequently an assessment of the impact of a refuelling transient on the power profiles is performed. The refuelling transient is found to increase the end flux peaking in the region adjacent to light water. (authors)

Public transparency Web sites for radiology practices: prevalence of price, clinical quality, and service quality information.

Science.gov (United States)

Rosenkrantz, Andrew B; Doshi, Ankur M

2016-01-01

To assess information regarding radiology practices on public transparency Web sites. Eight Web sites comparing radiology centers' price and quality were identified. Web site content was assessed. Six of eight Web sites reported examination prices. Other reported information included hours of operation (4/8), patient satisfaction (2/8), American College of Radiology (ACR) accreditation (3/8), on-site radiologists (2/8), as well as parking, accessibility, waiting area amenities, same/next-day reports, mammography follow-up rates, examination appropriateness, radiation dose, fellowship-trained radiologists, and advanced technologies (1/8 each). Transparency Web sites had a preponderance of price (and to a lesser extent service quality) information, risking fostering price-based competition at the expense of clinical quality. Copyright © 2016 Elsevier Inc. All rights reserved.

Role for ribosome-associated complex and stress-seventy subfamily B (RAC-Ssb) in integral membrane protein translation.

Science.gov (United States)

Acosta-Sampson, Ligia; Döring, Kristina; Lin, Yuping; Yu, Vivian Y; Bukau, Bernd; Kramer, Günter; Cate, Jamie H D

2017-12-01

Targeting of most integral membrane proteins to the endoplasmic reticulum is controlled by the signal recognition particle, which recognizes a hydrophobic signal sequence near the protein N terminus. Proper folding of these proteins is monitored by the unfolded protein response and involves protein degradation pathways to ensure quality control. Here, we identify a new pathway for quality control of major facilitator superfamily transporters that occurs before the first transmembrane helix, the signal sequence recognized by the signal recognition particle, is made by the ribosome. Increased rates of translation elongation of the N-terminal sequence of these integral membrane proteins can divert the nascent protein chains to the ribosome-associated complex and stress-seventy subfamily B chaperones. We also show that quality control of integral membrane proteins by ribosome-associated complex-stress-seventy subfamily B couples translation rate to the unfolded protein response, which has implications for understanding mechanisms underlying human disease and protein production in biotechnology. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

The correlates of urinary albumin to creatinine ratio (ACR) in a high risk Australian aboriginal community.

Science.gov (United States)

Wang, Zaimin; Hoy, Wendy E; Wang, Zhiqiang

2013-08-16

Albuminuria marks renal disease and cardiovascular risk. It was estimated to contribute 75% of the risk of all-cause natural death in one Aboriginal group. The urine albumin/creatinine ratio (ACR) is commonly used as an index of albuminuria. This study aims to examine the associations between demographic factors, anthropometric index, blood pressure, lipid-protein measurements and other biomarkers and albuminuria in a cross-sectional study in a high-risk Australian Aboriginal population. The models will be evaluated for albuminuria at or above the microalbuminuria threshold, and at or above the "overt albuminuria" threshold with the potential to distinguish associations they have in common and those that differ. This was a cross-sectional study of 598 adults aged 18-76 years. All participants were grouped into quartiles by age. Logistic regression models were used to explore the correlates of ACR categories. The significant correlates were systolic blood pressure (SBP), C-reactive protein (CRP), uric acid, diabetes, gamma-glutamyl transferase (GGT) (marginally significant, p=0.054) and serum albumin (negative association) for ACR 17+ (mg/g) for men and 25+ for women. Independent correlates were SBP, uric acid, diabetes, total cholesterol, alanine amino transferase (ALT), Cystatin C and serum albumin (negative association) for overt albuminuria; and SBP, CRP and serum albumin only for microalbuminuria. This is the most detailed modelling of pathologic albuminuria in this setting to date. The somewhat variable association with risk factors suggests that microalbuminuria and overt albuminuria might reflect different as well as shared phenomena.

Closure Plan for the Area 5 Radioactive Waste Management Site at the Nevada Test Site

International Nuclear Information System (INIS)

NSTec Environmental Management

2008-01-01

The Area 5 Radioactive Waste Management Site (RMWS) at the Nevada Test Site (NTS) is managed and operated by National Security Technologies, LLC (NSTec), for the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO). This document is the first update of the preliminary closure plan for the Area 5 RWMS at the NTS that was presented in the Integrated Closure and Monitoring Plan (DOE, 2005a). The major updates to the plan include a new closure schedule, updated closure inventory, updated site and facility characterization data, the Title II engineering cover design, and the closure process for the 92-Acre Area of the RWMS. The format and content of this site-specific plan follows the Format and Content Guide for U.S. Department of Energy Low-Level Waste Disposal Facility Closure Plans (DOE, 1999a). This interim closure plan meets closure and post-closure monitoring requirements of the order DOE O 435.1, manual DOE M 435.1-1, Title 40 Code of Federal Regulations (CFR) Part 191, 40 CFR 265, Nevada Administrative Code (NAC) 444.743, and Resource Conservation and Recovery Act (RCRA) requirements as incorporated into NAC 444.8632. The Area 5 RWMS accepts primarily packaged low-level waste (LLW), low-level mixed waste (LLMW), and asbestiform low-level waste (ALLW) for disposal in excavated disposal cells

Closure Plan for the Area 5 Radioactive Waste Management Site at the Nevada Test Site

Energy Technology Data Exchange (ETDEWEB)

NSTec Environmental Management

2008-09-01

The Area 5 Radioactive Waste Management Site (RMWS) at the Nevada Test Site (NTS) is managed and operated by National Security Technologies, LLC (NSTec), for the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO). This document is the first update of the preliminary closure plan for the Area 5 RWMS at the NTS that was presented in the Integrated Closure and Monitoring Plan (DOE, 2005a). The major updates to the plan include a new closure schedule, updated closure inventory, updated site and facility characterization data, the Title II engineering cover design, and the closure process for the 92-Acre Area of the RWMS. The format and content of this site-specific plan follows the Format and Content Guide for U.S. Department of Energy Low-Level Waste Disposal Facility Closure Plans (DOE, 1999a). This interim closure plan meets closure and post-closure monitoring requirements of the order DOE O 435.1, manual DOE M 435.1-1, Title 40 Code of Federal Regulations (CFR) Part 191, 40 CFR 265, Nevada Administrative Code (NAC) 444.743, and Resource Conservation and Recovery Act (RCRA) requirements as incorporated into NAC 444.8632. The Area 5 RWMS accepts primarily packaged low-level waste (LLW), low-level mixed waste (LLMW), and asbestiform low-level waste (ALLW) for disposal in excavated disposal cells.

A cost-saving statistically based screening technique for focused sampling of a lead-contaminated site

International Nuclear Information System (INIS)

Moscati, A.F. Jr.; Hediger, E.M.; Rupp, M.J.

1986-01-01

High concentrations of lead in soils along an abandoned railroad line prompted a remedial investigation to characterize the extent of contamination across a 7-acre site. Contamination was thought to be spotty across the site reflecting its past use in battery recycling operations at discrete locations. A screening technique was employed to delineate the more highly contaminated areas by testing a statistically determined minimum number of random samples from each of seven discrete site areas. The approach not only quickly identified those site areas which would require more extensive grid sampling, but also provided a statistically defensible basis for excluding other site areas from further consideration, thus saving the cost of additional sample collection and analysis. The reduction in the number of samples collected in ''clean'' areas of the site ranged from 45 to 60%

Post-Closure Inspection, Sampling, and Maintenance Report for the Salmon, Mississippi, Site Calendar Year 2010

International Nuclear Information System (INIS)

2011-01-01

This report summarizes the annual inspection, sampling, measurement, and maintenance activities performed at the Salmon, Mississippi, Site in calendar year 2010. The draft Long-Term Surveillance and Maintenance Plan for the Salmon Site, Lamar County Mississippi (DOE 2007) specifies the submittal of an annual report of site activities with the results of sample analyses. The Salmon, MS, Site is a federally owned site located in Lamar County, MS, approximately 12 miles west of Purvis, MS, and about 21 miles southwest of Hattiesburg, MS (Figure 1). The U.S. Department of Energy (DOE), a successor agency to the U.S. Atomic Energy Commission (AEC), is responsible for the long-term surveillance and maintenance of the 1,470-acre site. DOE's Office of Legacy Management (LM) is the operating agent for the surface and subsurface real estate.

Toxoplasma gondii antibodies in domiciled cats from rio branco Municipality, Acre State, Brazil

Directory of Open Access Journals (Sweden)

Soraia Figueiredo de Souza

2015-12-01

Full Text Available Blood samples were collected from 89 cats to assess the prevalence of IgG antibodies against Toxoplasma gondii by indirect immunofluorescence (IIF and the possible risk factors associated with feline Toxoplasma gondii infection. An epidemiological questionnaire was developed and implemented for owners of domestic cats domiciled in Rio Branco, Acre. The results were statistically evaluated with the odds ratio and chi-square tests, considering the significance level of 5%. Of 89 animals’ samples, 22 had antibodies against Toxoplasma gondii. Among the 22 reactive animals, 15 (68.19% were female, 15 (68.19% were less than one year old and 20 (90% were cross breed. Concerning risk factors, there was no difference (p > 0.05 between the variables evaluated by the chi-square test. Moreover, 16 (72% cats were fed a mixed diet, 20 (90% of the cats had hunting habits, 18 (81% had contact with animals of another species, 11 (50% had access to the street, and 22 (95% lived in homes that had areas of grass or dirt. In conclusion, the prevalence of anti-Toxoplasma gondii in domestic cats was 22.7%, and there were no significant risk factors for feline toxoplasmosis in the municipality of Rio Branco, Acre.

Satellite power system (SPS). Rectenna siting: availability and distribution of nominally eligible sites

Energy Technology Data Exchange (ETDEWEB)

1980-11-01

Siting of 60 ground receiving stations (rectennas) for the SPS may pose a problem due to the large area per rectenna (15,000 hectares, 38,000 acres) and numerous siting constraints. This study analyzes areas potentially eligible for rectenna sites by mapping, at a national scale, those conditions which would preclude rectenna construction. These exclusion variables which reflect restricted lands, topography, safety, national policy and electromagnetic (microwave) effects, have been computer encoded and tabulated. Subsequent analysis of the nine electric power planning regions that make up the contiguous states indicate an apparently adequate number of nominally eligible sites in all regions in comparison to projected electrical generation. Eligibility in this context means only that areas were not excluded in this national level analysis; more detailed investigation may reveal purely local constraints or smaller scale exclusions. A second major qualification relates to small isolated eligible areas. Eliminating individual eligible clusters with less than nine times the area of one rectenna eliminates much of the Eastern US; a four-to-one adjacent eligible area test poses no such problem. An independant study of the placement of 60 nominal sites in relation to projected load centers reveals that, even with modest transmission distances, the supply of eligible areas is not a key constraint, except perhaps in the Mid-Atlantic (Electric Reliability) Council Region. Even when several less critical (potential) exclusions are considered, more than 19% of the US is eligible; every region except Mid-Atlantic has at least 50 times an many eligible sites as are required.

Por que um Estado com vocação florestal como o Acre não produz palmito?

Directory of Open Access Journals (Sweden)

Markus Erwin Brose

2016-04-01

Full Text Available Palm heart constitutes a major non-timber forest product within the pro poor development strategy in Acre State. The 1990s it witnessed a boom of native palm processing, that proved to be unsustainable and processing units migrated to northern Bolivia. This article aims to rescue the impacts of this process, and subsequent initiatives of peach palm cultivation, originated by public and private, which, however, experienced difficulties to access the market. Given the scarce bibliography on the topic, we seek to contribute to the debate of this productive chain in Acre as an input to the debate on strategies to support the marketing of non-wood forest products, essential to the state’s policy of providing value to the standing forest.

Selected hydrologic data from a wastewater spray disposal site on Hilton Head Island, South Carolina

Science.gov (United States)

Speiran, G.K.; Belval, D.L.

1985-01-01

This study presents data collected during a study of the effects on the water table aquifer from wastewater application at rates of up to 5 inches per week on a wastewater spray disposal site on Hilton Head Island, South Carolina. The study was conducted from April 1982 through December 1983. The disposal site covers approximately 14 acres. Water level and water quality data from organic, inorganic, and nutrient analyses from the water table aquifer to a depth of 30 ft and similar water quality data from the wastewater treatment plant are included. (USGS)

Caracterização físico-quimica de farinhas oriundas de variedades de mandioca utilizadas no vale do Juruá, Acre Physicochemical characteristics of flours deriving of cassava varieties used in the Vale do Juruá, Acre

Directory of Open Access Journals (Sweden)

Joana Maria Leite de Souza

2008-12-01

Full Text Available Algumas características de farinha de mandioca dependem da variedade da raiz utilizada para o processamento. Objetivou-se avaliar as características físico-químicas da farinha de mandioca oriundas de variedades utilizadas no estado do Acre. Os tratamentos foram compostos pelas variedades: T1= Paxiubão, T2= Im221, T3 = Caboquinha, T4 = Araçá, T5 = Colonial, T6 = Branquinha, T7 = Panati e T8 = Mansa e Brava. Foram coletadas amostras das oito variedades de mandioca em casas-de-farinha no município de Cruzeiro do Sul, Acre. As raízes foram transportadas via aérea para o Laboratório de Tecnologia de Alimentos da Embrapa-AC, na cidade de Rio Branco, Acre. Foram avaliados: teor de umidade, cinzas, lipídios, proteína, fibra bruta, carboidratos, acidez, pH e atividade de água. Todas as amostras se apresentaram de acordo com os padrões estabelecidos pela Legislação Brasileira para farinha de mandioca quanto ao teor de umidade, cinzas e carboidratos. As farinhas analisadas apresentam teores baixos de fibras e baixa acidez. A atividade de água das farinhas analisadas esteve abaixo do limite mínimo capaz de permitir o desenvolvimento de microrganismos. As variedades Araçá, Colonial e Branquinha se mostraram adequadas para a fabricação de farinha de mandioca devido, principalmente, ao elevado teor de proteína e carboidratos presente nas farinhas produzidas.Some characteristics of the cassava depend on the variety used for the processing. The objectified of this study was to evaluate physicochemical characteristics of the cassava flour from varieties used in Acre. The treatments were composed by the varieties: T1 = Paxiubão, T2 = Im221, T3 = Caboquinha, T4 = Araçá, T5 = Colonial, T6 = Branquinha, T7 = Panati and T8 = Mansa e Brava. Samples of flour of eight cassava varieties were collect in cassava mils in Cruzeiro do Sul. The samples were sent by airmail to Rio Branco, Acre, to be analyzed in the Food and Technology Laboratory at

Demystifying "oxi" cocaine: Chemical profiling analysis of a "new Brazilian drug" from Acre State.

Science.gov (United States)

da Silva Junior, Ronaldo C; Gomes, Cezar S; Goulart Júnior, Saulo S; Almeida, Fernanda V; Grobério, Tatiane S; Braga, Jez W B; Zacca, Jorge J; Vieira, Maurício L; Botelho, Elvio D; Maldaner, Adriano O

2012-09-10

Recent information from various sources suggests that a new illicit drug, called "oxi", is being spread across Brazil. It would be used in the smoked form and it would look like to crack cocaine: usually small yellowish or light brown stones. As fully released in the media, "oxi" would differ from crack cocaine in the sense that crack would contain carbonate or bicarbonate salts whereas "oxi" would include the addition of calcium oxide and kerosene (or gasoline). In this context, this work presents a chemical profiling comparative study between "oxi" street samples seized by the Civil Police of the State of Acre (CP/AC) and samples associated with both international and interstate drug trafficking seized by the Brazilian Federal Police in Acre (FP/AC). The outcome of this work assisted Brazilian authorities to stop inaccurate and alarmist releases on this issue. It may be of good use by the forensic community in order to better understand matters in their efforts to guide local law enforcement agencies in case such claims reach the international illicit market. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

White paper from the ACR Task Force on Print Media in Radiology.

Science.gov (United States)

Duszak, Richard; Haines, G Rebecca; Van Duyn Wear, Vanessa; Lexa, Frank James; Bashir, Mustafa; D'Souza, Sharon; Carlos, Ruth; Chen, James Yen-Yu; King, Bernard F; Wald, Christoph

2011-10-01

The rapidly changing technological and business environment in which scientific journals are published will necessitate ongoing reassessment of operations, goals, and priorities. In this white paper, the ACR Task Force on Print Media in Radiology reviews the history and role of print media in radiology; discusses current and anticipated societal, technological, and financial challenges; and explores a variety of strategies to help ensure the relevance of professional society publishing in the future. Copyright © 2011 American College of Radiology. Published by Elsevier Inc. All rights reserved.

EULAR definition of erosive disease in light of the 2010 ACR/EULAR rheumatoid arthritis classification criteria

NARCIS (Netherlands)

van der Heijde, Désirée; van der Helm-van Mil, Annette H. M.; Aletaha, Daniel; Bingham, Clifton O.; Burmester, Gerd R.; Dougados, Maxime; Emery, Paul; Felson, David; Knevel, Rachel; Kvien, Tore K.; Landewé, Robert B. M.; Lukas, Cédric; McInnes, Iain; Silman, Alan J.; Smolen, Josef S.; Stanislawska-Biernat, Ewa; Zink, Angela; Combe, Bernard

2013-01-01

The aim of this report was to propose a definition for erosive disease in the context of inflammatory arthritis in light of the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) rheumatoid arthritis (RA) criteria for use in clinical practice and studies. A EULAR

78 FR 24157 - Foreign-Trade Zone 20-Suffolk, Virginia; Application for Reorganization and Expansion Under the...

Science.gov (United States)

2013-04-24

...)-- Kerma Medical Products, 215 Suburban Drive, Suffolk; Site 2 (10 acres)--Evans Distribution Systems, 324... Charles Sustainable Technologies Industrial Park, U.S. 13 on SR 1108, Cape Charles; Site 19 (323 acres... Production Road, Norfolk; Site 23 (101 acres)--Virginia Commerce Center, 351 Kenyon Road, Suffolk; Site 24...

Freqüência de anemia infecciosa em eqüinos no Acre, 1986 a 1996

Directory of Open Access Journals (Sweden)

Santos R.M.L.

2001-01-01

Full Text Available Foram analisadas as fichas de 9.963 eqüídeos do Acre, submetidos ao teste de imunodifusão em gel de ágar (IDGA para anemia infecciosa eqüina (AIE, no período de 1986 a 1996. As regiões sócio-ecológicas da Bacia do Alto Juruá, Alto Acre e Alta Bacia do Purus apresentaram os maiores índices da doença, o que caracteriza a associação entre região e positividade. Essas áreas são fronteiriças com o Peru, Bolívia e o Estado do Amazonas, são distantes de Rio Branco, capital do Estado, onde muitas vezes é difícil o acesso pelas estradas, revelando serem áreas de risco. As regiões Oriental e Rio Branco apresentaram baixos índices de positividade. Não se observou diferença estatística entre animais positivos e negativos quanto à espécie, sexo, raça e idade.

Switch-loop flexibility affects transport of large drugs by the promiscuous AcrB multidrug efflux transporter.

Science.gov (United States)

Cha, Hi-jea; Müller, Reinke T; Pos, Klaas M

2014-08-01

Multidrug efflux transporters recognize a variety of structurally unrelated compounds for which the molecular basis is poorly understood. For the resistance nodulation and cell division (RND) inner membrane component AcrB of the AcrAB-TolC multidrug efflux system from Escherichia coli, drug binding occurs at the access and deep binding pockets. These two binding areas are separated by an 11-amino-acid-residue-containing switch loop whose conformational flexibility is speculated to be essential for drug binding and transport. A G616N substitution in the switch loop has a distinct and local effect on the orientation of the loop and on the ability to transport larger drugs. Here, we report a distinct phenotypical pattern of drug recognition and transport for the G616N variant, indicating that drug substrates with minimal projection areas of >70 Å(2) are less well transported than other substrates. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

SU-F-J-143: Initial Assessment of Image Quality of An Integrated MR-Linac System with ACR Phantom

Energy Technology Data Exchange (ETDEWEB)

Wang, J; Fuller, C [MD Anderson Cancer Center, Houston, TX (United States); Yung, J; Kadbi, M; Ding, Y; Ibbott, G [UT MD Anderson Cancer Center, Houston, TX (United States)

2016-06-15

Purpose/Objective(s): To assess the image quality of an integrated MR-Linac system and compare with other MRI systems that are primarily used for diagnostic purposes. Materials/Methods: An ACR MRI quality control (QC) phantom was used to evaluate the image quality of a fully integrated 1.5T MRI-Linac system recently installed at our institution. This system has a new split magnet design which gives the magnetic field strength of 1.5T. All images were acquired with a set of phased-array surface coils which are designed to have minimal attention of radiation beam. The anterior coil rests on a coil holder which keeps the anterior coil’s position consistent for QA purposes. The posterior coil is imbedded in the patient couch. Multiple sets of T1, T2/PD images were acquired using the protocols as prescribed by the ACR on three different dates, ranging 3 months apart. Results: The geometric distortion are within 0.5 mm in the axial scans and within 1mm in the saggital (z-direction) scans. Slice thickness accuracy, image uniformity, ghosting ratio, high contrast detectability are comparable to other 1.5T diagnostic MRI scanners. The low-contrast object detectability are lower comparatively, which is a result of using the body array coil. Additionally, the beam’s-eye-view images (oblique coronal and saggital images) have minimal geometric distortion at all linac gantry angles tested. No observable changes or drift in image quality is found from images acquired 3 month apart. Conclusion: Despite the use of a body array surface coil, the image quality is comparable to that of an 1.5T MRI scanner and is of sufficient quality to pass the ACR MRI accreditation program. The geometric distortion of the MRI system of the integrated MR-Linac is within 1mm for an object size similar to the ACR phantom, sufficient for radiation therapy treatment purpose. The authors received corporate sponsored research grants from Elekta which is the vendor for the MR-Linac evaluated in this

Best Practices for Siting Solar Photovoltaics on Municipal Solid Waste Landfills. A Study Prepared in Partnership with the Environmental Protection Agency for the RE-Powering America's Land Initiative: Siting Renewable Energy on Potentially Contaminated Land and Mine Sites

Energy Technology Data Exchange (ETDEWEB)

Kiatreungwattana, K.; Mosey, G.; Jones-Johnson, S.; Dufficy, C.; Bourg, J.; Conroy, A.; Keenan, M.; Michaud, W.; Brown, K.

2013-04-01

The Environmental Protection Agency and the National Renewable Energy Laboratory developed this best practices document to address common technical challenges for siting solar photovoltaics (PV) on municipal solid waste (MSW) landfills. The purpose of this document is to promote the use of MSW landfills for solar energy systems. Closed landfills and portions of active landfills with closed cells represent thousands of acres of property that may be suitable for siting solar photovoltaics (PV). These closed landfills may be suitable for near-term construction, making these sites strong candidate to take advantage of the 30% Federal Business Energy Investment Tax Credit. It was prepared in response to the increasing interest in siting renewable energy on landfills from solar developers; landfill owners; and federal, state, and local governments. It contains examples of solar PV projects on landfills and technical considerations and best practices that were gathered from examining the implementation of several of these projects.

Challenges with Final Status Surveys at a Large Decommissioning Site - 13417

International Nuclear Information System (INIS)

Downey, Heath; Collopy, Peter; Shephard, Eugene; Walter, Nelson; Conant, John

2013-01-01

As part of decommissioning a former nuclear fuel manufacturing site, one of the crucial final steps is to conduct Final Status Surveys (FSS) in order to demonstrate compliance with the release criteria. At this decommissioning site, the area for FSS was about 100 hectares (248 acres) and included varying terrain, wooded areas, ponds, excavations, buildings and a brook. The challenges in performing the FSS included determining location, identifying FSS units, logging gamma walkover survey data, determining sample locations, managing water in excavations, and diverting water in the brook. The approaches taken to overcome these challenges will be presented in the paper. The paper will present and discuss lessons learned that will aid others in the FSS process. (authors)

DOI criticized for failing to inventory hazardous waste sites on federal lands

International Nuclear Information System (INIS)

Anon.

1993-01-01

The Department of the Interior (DOI) manages approximately 440 million acres of public land across the United States, including national parks and forests, wildlife refuges, fish hatcheries, and water and hydroelectric projects. At these facilities, hazardous wastes are commonly generated through such activities as oil and gas drilling, coal mining, hydroelectric plant operation, and pesticide application. Consequently, a significant number of DOI sites are probably contaminated and thus must be identified, assessed, and remediated. 2 refs., 1 tab

Post-Closure Inspection, Sampling, and Maintenance Report for the Salmon, Mississippi, Site Calendar Year 2010

Energy Technology Data Exchange (ETDEWEB)

None

2011-03-01

This report summarizes the annual inspection, sampling, measurement, and maintenance activities performed at the Salmon, Mississippi, Site in calendar year 2010. The draft Long-Term Surveillance and Maintenance Plan for the Salmon Site, Lamar County Mississippi (DOE 2007) specifies the submittal of an annual report of site activities with the results of sample analyses. The Salmon, MS, Site is a federally owned site located in Lamar County, MS, approximately 12 miles west of Purvis, MS, and about 21 miles southwest of Hattiesburg, MS (Figure 1). The U.S. Department of Energy (DOE), a successor agency to the U.S. Atomic Energy Commission (AEC), is responsible for the long-term surveillance and maintenance of the 1,470-acre site. DOE's Office of Legacy Management (LM) is the operating agent for the surface and subsurface real estate.

Long-term surveillance plan for the Canonsburg, Pennsylvania, disposal site

International Nuclear Information System (INIS)

1995-10-01

This document establishes elements of the US Department of Energy's (DOE) Long-Term Surveillance Plan for the Canonsburg, Pennsylvania, disposal site. The US Nuclear Regulatory Commission (NRC) will use this plan in support of license issuance for the long-term surveillance of the Canonsburg site. The Canonsburg (CAN) site is located within the borough of Canonsburg, Washington County, in southwestern Pennsylvania. The Canonsburg site covers approximately 30 acres (74 hectares). The disposal cell contains approximately 226,000 tons (241,000 tons) of residual radioactive material (RRM). Area C is southeast of the Canonsburg site, between Strabane Avenue and Chartiers Creek. Contaminated soils were removed from Area C during the remedial action, and the area was restored with uncontaminated fill material.After this cleanup, residual quantities of thorium-230 were detected at several Area C locations. The remedial action plan did not consider the ingrowth of radium-226 from thorium-230 as part of the Area C cleanup, and only two locations contained sufficient thorium-230 concentrations to result in radium-226 concentrations slightly above the US Environmental Protection Agency (EPA) standards

Minimal requirements of ACR-NEMA digital imaging and communication standards

International Nuclear Information System (INIS)

Wang, Y.; Horrii, S.; Lehr, J.

1986-01-01

The American College of Radiology-National Electrical Manufacturers Association (ACR-NEMA) Digital Imaging and Communication Standards were formally adopted in December 1985. They are intended to facilitate management and communication of digital image information regardless of source, format, or device manufacturer; to promote the development and expansion of radiologic imaging and communication systems that can also interface with other systems of hospital information; and to allow the creation of diagnostic information databases that can be interrogated by a wide variety of devices distributed geographically. The Standards specify the hardware interface, a minimum set of software commands, and a consistent set of data formats for communication across the interface between an imaging device and a network interface unit or another imaging device

MANAGEMENT OF Amburana cearensis var. acreana IN ACRE STATE, BRAZIL

Directory of Open Access Journals (Sweden)

Evaldo Muñoz Braz

2014-06-01

Full Text Available http://dx.doi.org/10.5902/1980509814586This work has as its objectives: a to assess the geographical distribution and population structure of Amburana cearensis var. acreana; b to calculate sustainable cutting rates, according to stipulated cutting cycles, and c to simulate the projected recovery potential in volume based on the calculated cutting rate. It was used data from sustainable forest management plans, and the results will contribute for future decisions about its endangered condition. The results did not corroborate the information that Amburana cearensis var. acreana is endangered in Acre state. However the management sustainability will only be feasible if considered the ideal remaining population structure and the estimative of the optimal cutting rate according to the cutting cycle.

Cleanup Summary Report for the Defense Threat Reduction Agency Fiscal Year 2007, Task 6.7, U12u-Tunnel (Legacy Site), Nevada Test Site, Nevada

International Nuclear Information System (INIS)

2008-01-01

This letter serves as notice of completion for cleanup of the U12u-Tunnel (Legacy Site) as specified in the Defense Threat Reduction Agency (DTRA) Fiscal Year 2007 Statement of Work, Task 6.7. The U12u-Tunnel Legacy Site is located near the intersection of the U12u-Tunnel access road and the U12n-Tunnel access road in Area 12 of the Nevada Test Site (see Figure 1). The site encompasses 1.2 acres and was used to store miscellaneous mining equipment and materials that were used to support DTRA testing in Area 12. Field activities commenced February 11, 2008, and were completed February 20, 2008. Radiological surveys were performed on a drill jumbo and all material stored at the site. The drill jumbo was relocated to U12p-Tunnel portal and consolidated with other critical mining equipment for future use or storage. Ten truck loads of solid waste (53 tons) were shipped to the Nevada Test Site, Area 9 U10c Sanitary Landfill for disposal. No hazardous or radiological waste was generated at this site

Post-Closure Inspection, Sampling, and Maintenance Report for the Salmon, Mississippi, Site Calendar Year 2009

Energy Technology Data Exchange (ETDEWEB)

None

2010-10-01

This report summarizes the annual inspection, sampling, and maintenance activities performed on and near the Salmon, Mississippi, Site in calendar year 2009. The draft Long-Term Surveillance and Maintenance Plan for the Salmon Site, Lamar County, Mississippi (DOE 2007) specifies the submittal of an annual report of site activities and the results of sample analyses. This report complies with the annual report requirement. The Salmon, MS, Site is located in Lamar County, MS, approximately 12 miles west of Purvis, MS, and about 21 miles southwest of Hattiesburg, MS The site encompasses 1,470 acres and is not open to the general public. The U.S. Department of Energy (DOE), a successor agency to the U.S. Atomic Energy Commission (AEC), is responsible for the long-term surveillance and maintenance of the site. The DOE Office of Legacy Management (LM) was assigned responsibility for the site effective October 1, 2006

Development of a mixed waste management facility at the Nevada Test Site

International Nuclear Information System (INIS)

Dolenc, M.R.; Kendall, E.W.

1989-01-01

The US Department of Energy (DOE) produces some radioactive low-level wastes (LLW) which contain hazardous components. By definition, the management of those mixed wastes (MW) at the Nevada Test Site (NTS) requires compliance with US Environmental Protection Agency (EPA) and state of Nevada regulations for hazardous wastes, and DOE regulations for LLW. Preparations for operation of a separate Mixed Waste Management Unit (MWMU) in the 1990s are underway. The 167-acre MWMU will be a part of the 732-acre Area 5 Radioactive Waste Management Site (RWMS). The MWMU is being developed in response to a DOE Office of Defense Waste and Transporation Management need to provide enhanced capabilities and facilities for safe, secure, and efficient disposal of defense-related MW in accordance with DOE, EPA, and state of Nevada requirements. Planned activities relating to the development of the MWMU include completing National Environmental Policy Act (NEPA) requirements; responding to any notices of deficiencies (NODs) on the NTS Part B Permit application; conducting generator audits as part of the NTS MW certification program; optimizing the design and operation of the vadose zone monitoring system; developing protocols for the sampling and analysis of MW, and facility construction. This paper describes the permitting and regulatory environment, the specific application of the permit process to the NTS, and the phased development of an MWMU at the NTS

76 FR 48121 - Foreign-Trade Zone 77-Memphis, TN; Application for Reorganization and Expansion Under Alternative...

Science.gov (United States)

2011-08-08

... operators/users located within a grantee's ``service area'' in the context of the Board's standard 2,000... 3, 3 acres), 227 Highway 45 West, Humboldt; Site 4 (419 acres total)--at Memphis Depot Business Park... acres) at 5265 Hickory Hill Road, Memphis; Site 5 (5 acres)--Quality Packaging Services International...

Optimization of nonribosomal peptides production by a psychrotrophic fungus: Trichoderma velutinum ACR-P1.

Science.gov (United States)

Sharma, Richa; Singh, Varun P; Singh, Deepika; Yusuf, Farnaz; Kumar, Anil; Vishwakarma, Ram A; Chaubey, Asha

2016-11-01

Trichoderma is an anamorphic filamentous fungal genus with immense potential for production of small valuable secondary metabolites with indispensable biological activities. Microbial dynamics of a psychrotrophic strain Trichoderma velutinum ACR-P1, isolated from unexplored niches of the Shiwalik region, bestowed with rich biodiversity of microflora, was investigated for production of nonribosomal peptides (NRPs) by metabolite profiling by intact-cell mass spectrometry (ICMS) employing matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometer. Being the first report on NRPs production by T. velutinum, studies on optimization of growth conditions by Response Surface Methodology (RSM) for production of NRPs by ACR-P1 was carried out strategically. Multifold enhancement in the yield of NRPs belonging to subfamily SF4 with medium chain of amino acid residues having m/z 1437.9, 1453.9, and 1452.0 at pH 5.9 at 20 °C and of subfamily SF1 with long-chain amino acid residues having m/z 1770.2, 1784.2, 1800.1, 1802.1, and 1815.1 was achieved at pH 7.0 at 25 °C. Complexities of natural mixtures were thus considerably reduced under respective optimized culture conditions accelerating the production of novel microbial natural products by saving time and resources.

Site observational work plan for the UMTRA Project site at Tuba City, Arizona

International Nuclear Information System (INIS)

1994-09-01

The requirements for ground water compliance for Uranium Mill Tailings Remedial Action (UMTRA) Project sites, including the Tuba City, Arizona, site, are found in the Uranium Mill Tailings Radiation Control Act; Subparts B and C of the U.S. Environmental Protection Agency's Health and Environmental Protection Standards for Uranium and Thorium Mill Tailings (40 CFR 192 (1994)), and the associated proposed 1987 standards (52 FR 36000). During the surface remedial action, an estimated 1,400,000 cubic yards (yd 3 ) (1,100,000 cubic meters [m 3 ]) of uranium mill tailings and other contaminated materials were consolidated and stabilized in place in an unlined disposal cell covering 50 acres (20 hectares). The surface remedial action was completed in April 1990. Ground water beneath the Tuba City site was contaminated by subsurface migration of water from uranium ore processing activities. The main source of contaminants was water from the tailings piles that began in 1956 when the mill opened and ended in 1966 when the mill closed. 800,000 tons (725,000 tonnes) of uranium ore were processed onsite over a 10-year period. The wet tailings remaining after processing were placed as a slurry in three piles at the site. Water from these tailings then seeped into the ground and migrated downward to the ground water. The Tuba City site is currently in a post-stabilization, prelicensing status. The site is expected to remain in this status until licensed by the U.S. Nuclear Regulatory Commission (NRC) for long-term surveillance and maintenance. The preliminary ground water compliance strategy at the Tuba City site is active remediation-specific technology to be evaluated is in situ bioremediation. This selection was made because of the potential ability of bioremediation to reduce concentrations to lower levels than a conventional extraction system and to minimize disturbance of the water resource

The provisional ACR/EULAR definition of remission in RA : a comment on the patient global assessment criterion

NARCIS (Netherlands)

Vermeer, Marloes; Kuper, Hillechiena H.; van der Bijl, Arie E.; Baan, Henriette; Posthumus, Marcel D.; Brus, Herman L. M.; van Riel, Piet L. C. M.; van de Laar, Mart A. F. J.

Objectives. The provisional ACR/European League Against Rheumatism (EULAR) definition of remission in RA requires a score of 41 on the patient global assessment (PGA, 0-10 scale). We explored the relation between the PGA criterion and the patient's clinical disease state in an observational dataset.

Registros de ocorrência e novos hospedeiros de Gargaphia lunulata (Mayr (Hemiptera: Tingidae nos estados do Acre e Paraná

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Rodrigo Santos

2017-12-01

Abstract. The occurrence of Gargaphia lunulata (Mayr (Hemiptera: Tingidae was observed in leaves of four host plants: rue (Ruta graveolens L. and jack bean (Canavalia ensiformis (L. DC in an urban residential garden, in the municipality of Rio Branco, Acre State, Brazil and Crotalaria spectabilis (L., jack bean and okra (Abelmoschus esculentus L. Moench in a greenhouse, in the municipality of Londrina, Paraná State, Brazil. The colonies were found exclusively on the abaxial face of the leaves, causing chlorosis, wilting and early senescence of the same. Because G. lunulata is considered to be an important passion fruit pest in Brazil, the planting of the mentioned plant species, in intercropping or near to passion fruit crops, would not be recommended, since they could serve as plant species inoculum to passion fruit cultivation. Therefore, the occurrence of G. lunulata associated to R. graveolens and jack bean in Acre State; and C. spectabilis, jack bean, and okra, in Paraná State is record for the first time. In addition, the present work reports the first occurrence of this tingid to the States of Acre and Paraná and reports two new hosts for this insect, R. graveolens and C. spectabillis in Brazil.

Breast Cancer Screening for Average-Risk Women: Recommendations From the ACR Commission on Breast Imaging.

Science.gov (United States)

Monticciolo, Debra L; Newell, Mary S; Hendrick, R Edward; Helvie, Mark A; Moy, Linda; Monsees, Barbara; Kopans, Daniel B; Eby, Peter R; Sickles, Edward A

2017-09-01

Breast cancer is the most common non-skin cancer and the second leading cause of cancer death for women in the United States. Before the introduction of widespread mammographic screening in the mid-1980s, the death rate from breast cancer in the US had remained unchanged for more than 4 decades. Since 1990, the death rate has declined by at least 38%. Much of this change is attributed to early detection with mammography. ACR breast cancer screening experts have reviewed data from RCTs, observational studies, US screening data, and other peer-reviewed literature to update our recommendations. Mammography screening has consistently been shown to significantly reduce breast cancer mortality over a variety of study designs. The ACR recommends annual mammography screening starting at age 40 for women of average risk of developing breast cancer. Our recommendation is based on maximizing proven benefits, which include a substantial reduction in breast cancer mortality afforded by regular screening and improved treatment options for those diagnosed with breast cancer. The risks associated with mammography screening are also considered to assist women in making an informed choice. Copyright © 2017 American College of Radiology. Published by Elsevier Inc. All rights reserved.

An alternative proposal for the disposal of potentially contaminated railroad crossties at the Savannah River Site. Revision 1

International Nuclear Information System (INIS)

Hochel, R.C.

1996-06-01

The Savannah River Site (SRS) has accumulated approximately 300,000 crossties that have been replaced over a 40-year period of maintaining the site's 62 miles of railroad track. The ties reside in a pile on an open area of 2.3 acres near the site's F-Area facilities. A small fraction of the ties are potentially contaminated with radioactivity as a result of past site practices and service. Contamination was possible from occasional leaks in transport-casks moved by rail from the site's five nuclear materials production reactors to its two reprocessing facilities. Casks typically were filled with spent fuel, targets, and water from the reactor disassembly basins, which contained small amounts of fission and neutron activation product radioactivity normal to the operation of nuclear reactors

Performance of a radioactive waste internment site

International Nuclear Information System (INIS)

Bernhardt, D.E.; Owen, D.H.; Mishub, R.J.; Prewett, S.V.; Cole, L.W.

1990-01-01

Aerojet disposed of 30,000 cubic meters of uranium and thorium wastes in an engineered 12,000 square meter (3 acre) internment site in Tennessee. The operation, performed under a State of Tennessee source material license, is based on termination of the license with the material remaining in place, and the option of future commercial use of the site. The closure plan included a long-term monitoring program. Yearly monitoring of the site has verified performance within the design criteria. Full-time construction monitored by a licensed engineer and extensive testing of materials ensured construction of the site according to or better than the specifications. Surface subsidence of the site has averaged about 2.2 cm with a range of 0 to 4.3 cm at 11 settlement markers after 4 years. The anticipated settlement, based on design parameters, was between 15 and 25 cm. The present anticipated settlement is 8 to 15 cm, based on the as-built parameters, and the long-term monitoring results. Slope stability analysis indicates the stability has improved with time due to consolidation of materials and reduced groundwater activity as a result of site construction. There has been no need for corrective action maintenance due to erosion, sluffing of slopes, or subsidence. Groundwater monitoring indicates the materials have been isolated, and there have also been no indications of springs or leakage from the site. 9 refs., 2 figs., 3 tabs

The provisional ACR/EULAR definition of remission in RA: a comment on the patient global assessment criterion

NARCIS (Netherlands)

Vermeer, M.; Kuper, Hillechina H.; van der Bijl, Arie E.; Baan, H.; Posthumus, Marcel D.; Brus, Herman L.M.; van Riel, Piet L.C.M.; van de Laar, Mart A F J

2012-01-01

Objectives. The provisional ACR/European League Against Rheumatism (EULAR) definition of remission in RA requires a score of ≤1 on the patient global assessment (PGA, 0–10 scale). We explored the relation between the PGA criterion and the patient's clinical disease state in an observational dataset.

Detection of potential AcrAB-TolC multidrug efflux pump inhibitor in calyces extract of Hibiscus sabdariffa

Directory of Open Access Journals (Sweden)

Nehaya Al-Karablieh

2017-12-01

Full Text Available Aim: The aim of this study is to investigate occurrence of potential efflux pump inhibitor (EPI against AcrAB-TolC efflux pump in the methanol extract of H. sabdariffa. Materials and Methods: Calyces of H. sabdariffa were purchased from the local market in April 2014, methanol extract of H. sabdariffa was subjected to agar plate diffusion against Escherichia coli TG1 and its ∆acrB-∆tolC and thin layer chromatography (TLC bioassay. The corresponding EPI fraction was eluted by methanol. The synergistic effect of antimicrobials and EPI fraction was measured by minimum inhibitory concentration (MIC determination for E. coli and Erwinia amylovora strains, and the ability of EPI fraction to enhance EtBr accumulation was conducted. Results: E. coli TG1 was more sensitive to the methanol extracts of H. sabdariffa than E. coli ∆acrB-∆tolC, and inhibition zone corresponding to flavones on TLC bioassay plate has been formed which might be related to the fraction of potential EPI. The MIC values revealed that EPI fraction enhanced the activity of the used antimicrobials by 4 to 8 folds in E. coli TG1 and by 4 to 10 folds in E. amylovora 1189. Addition of EPI fraction in a dose-dependent manner increased the intercellular accumulation of Ethidium Bromide (EtBr in the wild type stains of E. coli TG1 and E. amylovora 1189. Conclusion: EPI fraction behaves like a multidrug efflux pump inhibitor and further investigation should be conducted for determination of the chemical structure of EPI fraction. [J Complement Med Res 2017; 6(4.000: 357-363

Stress Introduction Rate Alters the Benefit of AcrAB-TolC Efflux Pumps.

Science.gov (United States)

Langevin, Ariel M; Dunlop, Mary J

2018-01-01

Stress tolerance studies are typically conducted in an all-or-none fashion. However, in realistic settings-such as in clinical or metabolic engineering applications-cells may encounter stresses at different rates. Therefore, how cells tolerate stress may depend on its rate of appearance. To address this, we studied how the rate of stress introduction affects bacterial stress tolerance by focusing on a key stress response mechanism. Efflux pumps, such as AcrAB-TolC of Escherichia coli , are membrane transporters well known for the ability to export a wide variety of substrates, including antibiotics, signaling molecules, and biofuels. Although efflux pumps improve stress tolerance, pump overexpression can result in a substantial fitness cost to the cells. We hypothesized that the ideal pump expression level would involve a rate-dependent trade-off between the benefit of pumps and the cost of their expression. To test this, we evaluated the benefit of the AcrAB-TolC pump under different rates of stress introduction, including a step, a fast ramp, and a gradual ramp. Using two chemically diverse stresses, the antibiotic chloramphenicol and the jet biofuel precursor pinene, we assessed the benefit provided by the pumps. A mathematical model describing these effects predicted the benefit as a function of the rate of stress introduction. Our findings demonstrate that as the rate of introduction is lowered, stress response mechanisms provide a disproportionate benefit to pump-containing strains, allowing cells to survive beyond the original inhibitory concentrations. IMPORTANCE Efflux pumps are ubiquitous in nature and provide stress tolerance in the cells of species ranging from bacteria to mammals. Understanding how pumps provide tolerance has far-reaching implications for diverse fields, from medicine to biotechnology. Here, we investigated how the rate of stressor appearance impacts tolerance. We focused on two distinct substrates of AcrAB-TolC efflux pumps, the

76 FR 76934 - Foreign-Trade Zone 89-Las Vegas, NV; Application for Reorganization and Expansion Under...

Science.gov (United States)

2011-12-09

..., adjacent to McCarran International Airport, Las Vegas; Site 4: (37 acres)--North Las Vegas Business Center, North Las Vegas; Site 5: (516 acres)--AMPAC Development Company--Gibson Business Park, Las Vegas; Site 6...'' in the context of the Board's standard 2,000-acre activation limit for a general-purpose zone project...

78 FR 39254 - Foreign-Trade Zone 84-Houston, Texas; Application for Expansion

Science.gov (United States)

2013-07-01

...). FTZ 84 currently consists of 25 sites (2,756.74 acres total) at port facilities, industrial parks and... stated--are as follows: Site 1 (420.70 acres)--Houston Ship Channel Turning Basin, Clinton Drive at Highway 610 East Loop; Site 2 (97 acres)--Houston Ship Channel (Bulk Materials Handling Plant), north bank...

Quantification of aluminium in soil of the Solimões Formation, Acre State, Brazil

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Thiago Andrade Bernini

2013-12-01

Full Text Available The variety of soils in the State of Acre is wide and their chemical profiles are still not fully understood. The nature of the material of origin of these soils is indicated by the high aluminium (Al content, commonly associated with high calcium (Ca and magnesium (Mg contents. The study objective was to use different methods to quantify Al in soils from toposequences formed from material of a sedimentary nature originating from the Solimões Formation, in Acre, Brazil. Trenches were opened at three distinct points in the landscape: shoulder, backslope and footslope positions. Soil samples were collected for physical, chemical, mineralogical analyses. The Al content was quantified using different methods. High Al contents were found in most of these horizons, associated with high Ca and Mg levels, representing the predominant cations in the sum of exchangeable bases. The mineralogy indicates that the soils are still in a low weathering phase, with the presence of significant quantities of 2:1 minerals. Similar Al contents were determined by the methods of NaOH titration, xylenol orange spectrometry and inductively coupled plasma optical emission spectrometry. However, no consistent data were obtained by the pyrocatechol violet method. Extraction with KCl overestimated the exchangeable Al content due to its ability to extract the non-exchangeable Al present in the smectite interlayers. It was observed that high Al contents are related to the instability of the hydroxyl-Al smectite interlayers.

Superfund Record of Decision (EPA region 2): Glen Ridge Radium site, Essex County, NJ. (Second remedial action), June 1990. Final report

International Nuclear Information System (INIS)

1990-01-01

The 90-acre Glen Ridge Radium site is a residential community in the Borough of Glen Ridge, Essex County, New Jersey. The site is adjacent to another Superfund site, the Montclair/West Orange site. The Glen Ridge site includes a community of 274 properties serviced by surface reservoirs in northern New Jersey. In the early 1900s, a radium processing or utilization facility was located in the vicinity of the site. EPA investigations in 1981 and 1983 confirmed the presence of gamma radiation contamination in the Glen Ridge area and in several adjacent houses. The ROD complements the previous 1989 ROD for this site and provides a final remedy. The primary contaminant of concern affecting the soil is radium 226

Análise da degradação ambiental na Amazônia Ocidental: um estudo de caso dos municípios do Acre

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Rubicleis Gomes da Silva

2004-01-01

Full Text Available Os resultados gerais divulgados pelo relatório final do GOVERNO DO ESTADO DO ACRE (2000 mostraram que parte da região sudeste do Estado do Acre vem sendo modificada há algumas décadas por um processo de ocupação iniciado por desflorestamentos e atividades agropecuárias. Segundo este relatório, o desmatamento e a queima da vegetação por atividades humanas foram as grandes transformadoras das paisagens acreanas e continuam a crescer muito nas últimas décadas. Diante do exposto, o objetivo principal deste trabalho foi elaborar um Índice de Degradação (ID que fosse capaz de medir o atual estágio de degradação ambiental em que se encontram os 22 municípios do Estado do Acre, na região norte do Brasil, procurando, também, agrupá-los em clusters para verificar características semelhantes entre eles. Os resultados indicam que o Estado do Acre possui um ID médio de 30,74%, possuindo como ID´s mínimos os municípios de Cruzeiro do Sul e Mâncio Lima com ID igual a zero e Manoel Urbano com um ID de 1,80%. A análise de cluster mostrou que determinadas regiões possuem um bom estado de conservação ambiental, no entanto, também deixou claro que alguns indicadores de degradação apresentam valores extremamente elevados.The general results disclosed by the State of Acre's final report (2000 showed that part of the Southeast area of the State has been modified for some decades by an occupation process triggered by deforestation and agricultural and cattle raising activities. According to this report, deforestation and burning of vegetation by human activities were the major transformers of the State landscapes and have increased in the last decades. Therefore, the main purpose of this work was to develop a Degradation Index (DI that would measure the current stage of environmental degradation of the 22 municipalities of State of Acre in the North region of Brazil also attempting to group them in clusters to verify similar

Maryland Power Plant Siting Project: an application of the ORNL-Land Use Screening Procedure

International Nuclear Information System (INIS)

Dobson, J.E.

1975-01-01

Since 1974 the Resource Analysis Group in the Regional and Urban Studies Section of the Oak Ridge National Laboratory (ORNL) has been engaged in developing a procedure for regional and local siting analysis known as the ORNL Land Use Screening Procedure (LUSP). This document is the final report of the Maryland Power Plant Siting Project (MPPSP) in which the ORNL LUSP was used to identify candidate areas for power plant sites in northern Maryland. Numerous candidate areas are identified on the basis of four different siting objectives: the minimization of adverse ecologic impact, the minimization of adverse socioeconomic impact, the minimization of construction and operating costs, and a composite of all siting objectives. Siting criteria have been defined for each of these objectives through group processing techniques administered to four different groups of siting specialists. The siting priorities and opinions of each group have been expressed quantitatively and applied to a geographic information system containing 52 variables for each 91.8-acre cell in the northern eight counties of Maryland

Maryland Power Plant Siting Project: an application of the ORNL-Land Use Screening Procedure

Energy Technology Data Exchange (ETDEWEB)

Dobson, J.E.

1975-01-01

Since 1974 the Resource Analysis Group in the Regional and Urban Studies Section of the Oak Ridge National Laboratory (ORNL) has been engaged in developing a procedure for regional and local siting analysis known as the ORNL Land Use Screening Procedure (LUSP). This document is the final report of the Maryland Power Plant Siting Project (MPPSP) in which the ORNL LUSP was used to identify candidate areas for power plant sites in northern Maryland. Numerous candidate areas are identified on the basis of four different siting objectives: the minimization of adverse ecologic impact, the minimization of adverse socioeconomic impact, the minimization of construction and operating costs, and a composite of all siting objectives. Siting criteria have been defined for each of these objectives through group processing techniques administered to four different groups of siting specialists. The siting priorities and opinions of each group have been expressed quantitatively and applied to a geographic information system containing 52 variables for each 91.8-acre cell in the northern eight counties of Maryland.

Nota sobre culicídeos (Diptera: Culicidae da bacia do rio Purus, Acre, Amazônia (Brasil

Directory of Open Access Journals (Sweden)

Natal Delsio

1992-01-01

Full Text Available Foram feitas coletas de mosquito (Diptera: Culicidae na área do projeto de Colonização Pedro Peixoto, no Estado do Acre, Brasil. Obteve-se um total de 4.588 exemplares pertencentes a 53 espécies ou grupos. Salienta-se a ocorrência de Anopheles (Nyssorhynchus oswaldoi.

Nota sobre culicídeos (Diptera: Culicidae da bacia do rio Purus, Acre, Amazônia (Brasil

Directory of Open Access Journals (Sweden)

Delsio Natal

1992-04-01

Full Text Available Foram feitas coletas de mosquito (Diptera: Culicidae na área do projeto de Colonização Pedro Peixoto, no Estado do Acre, Brasil. Obteve-se um total de 4.588 exemplares pertencentes a 53 espécies ou grupos. Salienta-se a ocorrência de Anopheles (Nyssorhynchus oswaldoi.

Chemical analyses of potash-bearing horizons from 21 exploratory holes drilled at a tentative site for the Waste Isolation Pilot Plant, Eddy County, New Mexico

International Nuclear Information System (INIS)

Griswold, G.B.

1977-09-01

Sandia Laboratories drilled 21 potash drill holes over an 18,960-acre site in east-central Eddy County, New Mexico, to evaluate potash resources as part of their Waste Isolation Pilot Plant (WIPP) project. This report furnishes assay information on samples obtained from the drilling program

Archaeological investigations at a toolstone source area and temporary camp: Sample Unit 19-25, Nevada Test Site, Nye County, Nevada. Technical report No. 77

Energy Technology Data Exchange (ETDEWEB)

Jones, R.C.; DuBarton, A.; Edwards, S.; Pippin, L.C.; Beck, C.M.

1993-12-31

Archaeological investigations were initiated at Sample Unit 19--25 to retrieve information concerning settlement and subsistence data on the aboriginal hunter and gatherers in the area. Studies included collection and mapping of 35.4 acres at site 26NY1408 and excavation and mapping of 0.02 acres at site 26NY7847. Cultural resources include two rock and brush structures and associated caches and a large lithic toolstone source area and lithic artifact scatter. Temporally diagnostic artifacts indicate periodic use throughout the last 12,000 years; however dates associated with projectile points indicate most use was in the Middle and Late Archaic. Radiocarbon dates from the rock and brush structures at site 26NY7847 indicate a construction date of A.D. 1640 and repair between A.D. 1800 and 1950 for feature 1 and between A.D. 1330 and 1390 and repair at A.D. 1410 for feature 2. The dates associated with feature 2 place its construction significantly earlier than similar structures found elsewhere on Pahute Mesa. Activity areas appear to reflect temporary use of the area for procurement of available lithic and faunal resources and the manufacture of tools.

Superfund record of decision (EPA Region 4): Marzone Inc. /Chevron Chemical Company Superfund Site, Operable Unit 1, Tifton, GA, September 1994

Energy Technology Data Exchange (ETDEWEB)

1994-09-30

This decision document (Record of Decision) presents the selected remedial action for the Marzone, Inc./Chevron Chemical Company Site in Tift County, Georgia. EPA has organized the work at this Site into two phases or operable units (OUs). Operable Unit No. 1 involves contamination on the 1.68-acre former Marzone pesticide blending area, part of the Slack Property, and railroad drainage ditch past the southwest corner of the horse pasture, and contaminated groundwater related to the Site. This first operable unit is broken down into two separate remedies; one for groundwater and the other for soil.

Genetic diversity of "Pimenta Longa" genotypes (Piper spp., Piperaceae of the Embrapa Acre germplasm collection

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Lúcia Helena de Oliveira Wadt

2004-01-01

Full Text Available The commonly known Pimenta longa is a commercially valuable natural resource found wild in Acre, Brazil. Specifically, three Piperaceae species with contested taxonomic status were studied, Piper hispidinervum, Piper aduncum, and Piper hispidum, to assesses the inter- and intra-specific genetic relationship of 49 Piper genotypes kept in the Pimenta longa germplasm collection at Embrapa Acre, using sixty six Random Amplified Polymorphic DNA (RAPD markers. The DNA polymorphism level detected was high (96.97%, but the marker frequencies for each species showed polymorphism levels of 79.4% for Piper hispidinervum and 5.3% for P. aduncum. The genetic similarity clustering analysis resulted in three distinct groups corresponding to Piper hispidinervum, Piper aduncum, and Piper hispidum. Four and nine characteristic RAPD markers were identified for P. hispidinervum and P. aduncum, respectively, supporting the existence of two separate species. However, six genotypes collected in Tarauacá county formed a distinct subgroup within the P. hispidinervum group and may be considered as an ecotype of this species or an intermediate between the P. hispidinervum and P. aduncum groups. More extensive sampling of both P. hispidinervum and P. aduncum populations throughout the region are needed to further establish their relation and its implication for breeding efforts.

Comparative effects of urea fertilizer and red alder in a site III, coast Douglas-fir plantation in the Washington Cascade Range.

Science.gov (United States)

Richard E. Miller; Harry W. Anderson; Marshall Murray; Rick. Leon

2005-01-01

Five randomly assigned treatments were used to quantify effects of adding varying numbers of red alder (Alnus rubra Bong.) or nitrogen (N) fertilization on growth of a 10-year-old conifer plantation at a medium quality site in the western Washington Cascade Range. Zero, 20, 40, and 80 alder trees per acre were retained along with about 300 conifers...

Avaliação de genótipos de cafeeiros Arabica e Robusta no estado do Acre Evaluation of Arabica and Robusta coffee genotypes in the state of Acre

Directory of Open Access Journals (Sweden)

Celso Luis Bergo

2008-02-01

Full Text Available Conduziu-se este trabalho, com o objetivo de introduzir e avaliar 40 genótipos de cafeeiros das espécies Coffea arabica e Coffea canephora nas condições edafoclimáticas do Estado do Acre, visando disponibilizar aos cafeicultores acreanos, cultivares com melhor potencial produtivo. Da espécie C. arabica foram avaliados genótipos das cultivares Icatu, Bourbon, Mundo Novo, Catuaí, Obatã e Catimor. Da espécie C. canephora foram avaliadas as cultivares Conilon e Robusta, caracterizadas como Grupo Robusta. Os genótipos utilizados foram provenientes do Instituto Agronômico de Campinas (IAC e da Embrapa Rondônia. O experimento foi conduzido no Campo Experimental da Embrapa Acre, Rio Branco, AC, no período de 1995 a 2004. O delineamento experimental foi em blocos casualizados com cinco repetições. As características avaliadas foram: produtividade, altura, diâmetro da copa e vigor. Da espécie C. arabica, grupo Icatu, destacou-se Icatu-PR-182039-1(IAC H 4782-7-788 com produtividade média de café beneficiado de 34 sc/ ha, Icatu IAC-4041; Icatu IAC-2945; Icatu IAC-2944-MT; Icatu IAC-4040 e Icatu IAC-4046 com produtividade variando de 20 a 26 sacas. Para o grupo Catuaí os melhores genótipos foram Obatã IAC 4275, Obatã IAC 1169 e Catimor IAC 4466 com produtividade média de café beneficiado de 49, 45 e 37 sacas por hectare respectivamente. Na espécie C. canephora foram avaliados 8 genótipos das cultivares Conilon e Robusta e quanto à produtividade não houve diferença estatística, observou-se incremento de 7 sacas/ha para a variedade Conilon IAC 66-3 quando comparado ao Conilon plantado na região. Nesta espécie os genótipos apresentaram sintomas de deficiência hídrica na época seca (julho/agosto.This work aimed to introduce and evaluate 40 coffee genotypes of Coffea arabica e Coffea canephora species in soil and weather conditions of Acre and had as main goal to provide cultivars to coffee producers with better potential of

77 FR 74697 - Meeting of the ACRS, Subcommittee on U.S. Evolutionary Power Reactor; Notice of Meeting

Science.gov (United States)

2012-12-17

..., Subcommittee on U.S. Evolutionary Power Reactor; Notice of Meeting The ACRS Subcommittee on U.S. Evolutionary Power Reactor (U.S. EPR) will hold a meeting on January 17, 2013, Room T-2B1, 11545 Rockville Pike... be made. Thirty-five hard copies of each presentation or handout should be provided to the DFO thirty...

What do we mean by social networking sites?

Science.gov (United States)

La Sala, Louise; Skues, Jason; Wise, Lisa

2014-01-01

The purpose of this study was to explore people's conceptual understanding of Social Networking Sites (SNSs) through exploring the combined use of a range of popular SNSs, including Facebook, Twitter, Myspace, Instagram, Tumblr, LinkedIn and Google Plus. Seventy-three adults, aged 18 to 63, participated in an online survey that used open-ended questions to ask how participants define and use different SNSs. Four themes were identified, including the explicit presentation and interpretation of different selves, the love-hate relationship with SNSs, privacy and danger concerns, and limited SNS knowledge. The findings from this study suggest that researchers need to consider how people use SNSs in combination as this influences the decisions people make about which SNS accounts they use and how they present themselves on these sites.

Mitigation and Monitoring Plan for impacted wetlands at the Gunnison UMTRA Project site, Gunnison, Colorado. Revision 1

Energy Technology Data Exchange (ETDEWEB)

1994-12-01

The Gunnison, Colorado, abandoned uranium mill site is one site being cleaned up by the DOE under UMTRCA authority. This site`s contaminated material is being transported to a disposal site on US Bureau of Land Management (BLM) land east of Gunnison. Remedial action activities have temporarily disturbed 0.8 acre (ac) (0.3 hectares [ha]) of wetlands and permanently eliminated 4.3 ac (1.7 ha). As required by the Clean Water Act, the US Army Corps of Engineers (USACE) prepared a Section 404 Permit that addresses the loss of wetlands as a result of remedial action at the Gunnison UMTRA Project site. The 404 permit includes this report as an attachment and it describes the wetland mitigation and monitoring plan. The DOE formulated this plan in consultation with the BLM and the USACE. This report represents a revised version of the mitigation and monitoring plan (DOE, 1992b).

Logging Activity in the Trinational Amazonian Region of Pando/Bolivia, Acre and Rond“nia/Brazil, and Madre de Dios/Peru: Analysis of Existing Data

Science.gov (United States)

Mendoza, E.; Brilhante, S. H.; Brown, I.; Peralta, R.; Rivero, S.; Melendez, N.

2002-12-01

Logging activity in the trinational southwestern Amazonia will grow in importance as a driver of regional land-use change as expanding road access facilitates both timber extraction and transport to international markets. Official data on current activity in this ~50 million ha region are limited and inconsistent with differences as much as twenty-fold between official estimates; nevertheless, they serve as guides for understanding the relative magnitude of logging activities. For 2000, an estimated 5 million m3 of timber were commercialized in Rondonia, 400,000 m3 in Acre, Brazil, and 200,000 m3 for the combined departments of Pando, Bolivia and Madre de Dios, Peru. About 70% of this timber originates from clear cutting done for pasture and agriculture activities, nearly a third from unregulated selective logging, and only 2% from managed selective logging. Eight timber species are preferentially extracted. The total area for timber concessions in Acre, Pando and Madre de Dios extends to about 4 million ha for a potential timber supply of 65 million m3. About 150,000 m3/yr of illegal timber is confiscated by federal and state agencies in Acre, Pando and Madre de Dios. Problems of enforcement in the region are due principally to the lack of trained personnel and little cooperation among agencies of the three countries. Proposed development plans indicate a 3- to >10-fold increase in logging activity in the Acre and Pando regions during the coming decade. More detailed studies are urgently needed to guide sustainable development of this resource in southwestern Amazonia.

Site observational work plan for the UMTRA Project Site at Tuba City, Arizona

International Nuclear Information System (INIS)

1994-09-01

The requirements for ground water compliance for Uranium Mill Tailings Remedial Action (UMTRA) Project sites, including the Tuba City, Arizona, site, are found in the Uranium Mill Tailings Radiation Control Act; Subparts B and C of the U.S. Environmental Protection Agency's Health and Environmental Protection Standards for Uranium and Thorium Mill Tailings (40 CFR 192 (1994)), and the associated proposed 1987 standards (52 FR 36000). During the surface remedial action, an estimated 1,400,000 cubic yards (yd 3 ) (1,100,000 cubic meters [m 3 ]) of uranium mill tailings and other contaminated materials were consolidated and stabilized in place in an unlined disposal cell covering 50 acres (20 hectares). The surface remedial action was completed in April 1990. Ground water beneath the Tuba City site was contaminated by subsurface migration of water from uranium ore processing activities. The main source of contaminants was water from the tailings piles that began in 1956 when the mill opened and ended in 1966 when the mill closed. A total of 800,000 tons (725,000 tonnes) of uranium ore were processed onsite over a 10-year period. Two processes were used to refine the ore: an acid leach process and a sodium carbonate alkaline process. Water from these tailings then seeped into the ground and migrated downward to the ground water. The Tuba City site is currently in a post-stabilization, prelicensing status. The preliminary ground water compliance strategy at the Tuba City site is active remediation. The specific technology to be evaluated is in situ bioremediation. This selection was made because of the potential ability of bioremediation to reduce concentrations to lower levels than a conventional extraction system and to minimize disturbance of the water resource

The Stephen F. Austin Experimental Forest

Science.gov (United States)

Cary C. Russell; Ronald E. Thill; David L. Kulhavy

2002-01-01

On December 14, 1944, the Seventy-Eighth United States Congress passed a bill that authorized the transfer of 2,560 acres in Nacogdoches County, Texas, to the research branch of the United States Forest Service (USFS). This land became the Stephen F. Austin Experimental Forest (SFAEF) on September 19. 1945. One of eighty-one federal experimental forests and ranges...

EnviroAtlas - Acres of USDA Farm Service Agency Conservation Reserve Program land by 12-Digit HUC for the Conterminous United States.

Data.gov (United States)

U.S. Environmental Protection Agency — This EnviroAtlas dataset shows the acres of land enrolled in the US Department of Agriculture (USDA)'s Conservation Reserve Program (CRP). The CRP is administered by...

78 FR 67333 - Foreign-Trade Zone 15-Kansas City, Missouri, Area; Application for Reorganization Under...

Science.gov (United States)

2013-11-12

... ``usage-driven'' FTZ sites for operators/users located within a grantee's ``service area'' in the context... City; Site 3 (9,667 acres total)--within the 10,000-acre Kansas City International Airport facility...,000 acres)--CARMAR Underground Business Park/CARMAR Industrial Park, No. 1 Civil War Road, Carthage...

76 FR 50717 - Foreign-Trade Zone 74, Baltimore, MD; Application for Reorganization/Expansion Under Alternative...

Science.gov (United States)

2011-08-16

... 28 (2.5 acres)-- McCormick & Company, Inc., 11102 McCormick Road, Hunt Valley (Baltimore County); Proposed Site 29 (17.6 acres)--McCormick & Company, Inc., 10901 Gilroy Road, Hunt Valley (Baltimore County); and, Proposed Site 30 (8.48 acres)--McCormick & Company, Inc., 4607 Appliance Drive, Belcamp (Harford...

75 FR 12729 - Foreign-Trade Zone 133-Quad-Cities, Iowa/Illinois; Application for Expansion

Science.gov (United States)

2010-03-17

... authority to expand the zone within the Davenport-Rock Island-Moline Customs and Border Protection port of... River Cities Business Park (223 acres); Proposed Site 2 (33 acres)--within Rock Island Arsenal, located at 1775 East Street, Rock Island (Rock Island County), Illinois; Proposed Site 3 (55 acres...

Monticello Mill Tailings Site, Operable Unit lll, Annual Groundwater Report, May 2015 Through April 2016

Energy Technology Data Exchange (ETDEWEB)

Nguyen, Jason [USDOE Office of Legacy Management (LM), Washington, DC (United States); Smith, Fred [Navarro Research and Engineering, Oak Ridge, TN (United States)

2016-10-01

This report provides the annual analysis of water quality restoration progress, cumulative through April 2016, for Operable Unit (OU) III, surface water and groundwater, of the U.S. Department of Energy (DOE) Office of Legacy Management (LM) Monticello Mill Tailings Site (MMTS). The MMTS is a Comprehensive Environmental Response, Compensation, and Liability Act National Priorities List site located in and near the city of Monticello, San Juan County, Utah. MMTS comprises the 110-acre site of a former uranium- and vanadium-ore-processing mill (mill site) and 1700 acres of surrounding private and municipal property. Milling operations generated 2.5 million cubic yards of waste (tailings) from 1942 to 1960. The tailings were impounded at four locations on the mill site. Inorganic constituents in the tailings drained from the impoundments to contaminate local surface water (Montezuma Creek) and groundwater in the underlying alluvial aquifer. Mill tailings dispersed by wind and water also contaminated properties surrounding and downstream of the mill site. Remedial actions to remove and isolate radiologically contaminated soil, sediment, and debris from the former mill site, Operable Unit I (OU I), and surrounding properties (OU II) were completed in 1999 with the encapsulation of the wastes in an engineered repository located on DOE property 1 mile south of the former mill site. This effectively removed the primary source of groundwater contamination; however, contamination of groundwater and surface water remains within OU III at levels that exceed water quality protection standards. Uranium is the primary contaminant of concern (COC). LM implemented monitored natural attenuation with institutional controls as the OU III remedy in 2004. Because groundwater restoration proceeded more slowly than expected and did not meet performance criteria established in the OU III Record of Decision (June 2004), LM implemented a contingency action in 2009 by an Explanation of

Honey quality of Melipona sp. bees in Acre, Brazil

Directory of Open Access Journals (Sweden)

Marcus Augusto Damaceno do Vale

2018-04-01

Full Text Available Honey from stingless bees (Melipona sp. is a nutritious and medicinal product economically valued in the informal Brazilian market, driven by the growing demand for natural products; however, its physicochemical characteristics are still unknown. Thus, the aim of this study is to evaluate the physicochemical profile of the stingless bee honey produced in Cruzeiro do Sul, Acre. Honey samples were analyzed following the methodology recommended by Ministério da Agricultura, Pecuária e Abastecimento; the following parameters were established: moisture, total sugars, reducing sugars, apparent sucrose, ash, crude protein, diastase activity, Brix degrees, free acidity, lactonic acidity, total acidity, pH, hydroxymethylfurfural, electrical conductivity, color and Lugol, Lund and Fiehe reactions. Results show that these parameters are not suitable for all samples, being incompatible with established standards, indicating that the current legislation on Apis mellifera is not suitable for all characters analyzed, mainly moisture content, corroborating the need to standardize guidelines for honey from stingless bees. Moreover, there was no tampering in the honeys analyzed.

Biologic overview for the Nevada Nuclear Waste Storage Investigations, Nevada Test Site, Nye County, Nevada

International Nuclear Information System (INIS)

Collins, E.; O'Farrell, T.P.; Rhoads, W.A.

1982-01-01

The Nevada Nuclear Waste Storage Investigations project study area includes five major vegetation associations characteristic of the transition between the northern extent of the Mojave Desert and the southern extent of the Great Basin Desert. A total of 32 species of reptiles, 66 species of birds, and 46 species of mammals are known to occur within these associations elsewhere on the Nevada Test Site. Ten species of plants, and the mule deer, wild horse, feral burro, and desert tortoise were defined as possible sensitive species because they are protected by federal and state regulations, or are being considered for such protection. The major agricultural resources of southern Nye County included 737,000 acres of public grazing land managed by the Bureau of Land Management, and 9500 acres of irrigated crop land located in the Beatty/Oasis valleys, the Amargosa Valley, and Ash Meadows. Range lands are of poor quality. Alfalfa and cotton are the major crops along with small amounts of grains, Sudan grass, turf, fruits, and melons. The largest impacts to known ecosystems are expected to result from: extensive disturbances associated with construction of roads, seismic lines, drilling pads, and surface facilities; storage and leaching of mined spoils; disposal of water; off-road vehicle travel; and, over several hundred years, elevated soil temperatures. Significant impacts to off-site areas such as Ash Meadows are anticipated if new residential developments are built there to accommodate an increased work force. Several species of concern and their essential habitats are located at Ash Meadows. Available literature contained sufficient baseline information to assess potential impacts of the proposed project on an area-wide basis. It was inadequate to support analysis of potential impacts on specific locations selected for site characterization studies, mining an exploratory shaft, or the siting and operation of a repository

76 FR 19783 - Draft Environmental Impact Statement for the Proposed Pueblo of Jemez 70.277-Acre Fee-to-Trust...

Science.gov (United States)

2011-04-08

.... Environmental Protection Agency (EPA) for the proposed approval of a 70.277 acre fee-to-trust transfer and..., location, and areas of environmental concern addressed in the DEIS are provided in the SUPPLEMENTARY..., Bureau of Indian Affairs, Southwest Regional Office, 1001 Indian School Road, NW., Albuquerque, New...

Summary of the ACRE inaugural meeting.

Science.gov (United States)

Bloomgarden, Zachary T

2009-01-01

The charter meeting of the Association of Clinical Researchers and Educators (ACRE) provided a powerful set of arguments against assertions that physician-industry collaboration is harmful and represents a "conflict of interest." Such collaboration has, in fact, improved medical care for patients, a case made overwhelmingly by patients and patient advocacy groups at the meeting. The contentions that physician-industry collaboration is problematic are not based on evidence. They depend on unjustified generalization from inevitable, sometimes egregious, but vanishingly uncommon adverse outcomes of industry-physician interaction without reference to how so much more commonly these interactions add value. Furthermore, the claim that physician-industry collaboration is unprofessional is refuted by rational scrutiny. Indeed, the term "conflict of interest" itself is vague, inviting subjectivity and deserving to be rejected. The unwarranted success of conflict of interest regulation has prevailed because of the failure of physicians, educators, and innovators, through apathy and intimidation, to pay attention to its fallacies and resist its dangers. It has arisen from activist ambitions and from misalignment between the purposes of medical practitioners, educators, and innovators and those of administrators in medical journals and in academic medical centers. The media and politicians have not appreciated these misalignments and have accepted conflict of interest arguments at face value. Regulation emanating from conflict of interest criticism is confusing, onerous, expensive, disrespectful, and damaging. Prohibitions against speaking about medical products inhibit physician and patient education concerning rapidly emerging and complex therapies. Input by physicians cognizant of compliance requirements into such presentations should be encouraged. Restrictions to the free flow of corporate support of academic health centers, professional societies, and patient

First emergence of acrAB and oqxAB mediated tigecycline resistance in clinical isolates of Klebsiella pneumoniae pre-dating the use of tigecycline in a Chinese hospital.

Directory of Open Access Journals (Sweden)

Xue Zhong

Full Text Available Tigecycline is one of the few therapeutic options for treating infections caused by some multi-drug resistant pathogens, such as Klebsiella pneumoniae. However, tigecycline-resistant K. pneumoniae has been discovered recently in China. From 2009 to 2013, nine tigecycline-resistant K. pneumoniae isolates were identified in our hospital. Six of nine strains were identified before using tigecycline. To investigate the efflux-mediated resistance mechanisms of K. pneumoniae, the expression of efflux pump genes (acrA, acrB, tolC, oqxA and oqxB and pump regulators (acrR, marA, soxS, rarA, rob and ramA were examined by real-time RT-PCR. Molecular typing of the tigecycline resistant strains was performed. ST11 was the predominant clone of K. pneumoniae strains, while ST1414 and ST1415 were novel STs. Efflux pump inhibitor (EPI-carbonyl cyanide chlorophenylhydrazone (CCCP was able to reverse the resistance patterns of 5 resistant K. pneumoniae strains. In comparison with strain A111, a tigecycline-susceptible strain (negative control, we found that the expression levels of efflux pump genes and pump regulators were higher in a majority of resistant strains. Higher expression levels of regulators rarA (2.41-fold, 9.55-fold, 28.44-fold and 18.31-fold, respectively and pump gene oqxB (3.87-fold, 31.96-fold, 50.61-fold and 29.45-fold, respectively were observed in four tigecycline resistant strains (A363, A361, A368, A373, respectively. Increased expression of acrB was associated with ramA and marA expression. To our knowledge, studies on tigecycline resistance mechanism in K. pneumoniae are limited especially in China. In our study, we found that both efflux pump AcrAB-TolC and OqxAB contributed to tigecycline resistance in K. pneumoniae isolates.

76 FR 30906 - Foreign-Trade Zone 277-Western Maricopa County, AZ; Application for Reorganization Under...

Science.gov (United States)

2011-05-27

... complex, Bullard Avenue and Van Buren Street, Goodyear; Site 2 (133 acres)--within the 286-acre Surprise Pointe Business Park, Waddell Road and Litchfield Road, Surprise; Site 3 (235 acres)--within the 1,600... comment is invited from interested parties. Submissions (original and 3 copies) shall be addressed to the...

78 FR 4381 - Foreign-Trade Zone 45-Portland, Oregon; Application for Reorganization and Expansion Under...

Science.gov (United States)

2013-01-22

... following sites: Site 1 (1,830 acres)--Rivergate Industrial Park, Port Terminal Nos. 5 and 6, and the... Way and NE Alderwood Road, Portland; Site 3 (254 acres)--Portland Ship Repair Yard, 5555 N. Channel...

Intensive archaeological survey of the proposed Savannah River Ecology Laboratory Conference Center and Educational Facility, Savannah River Site, Aiken County, South Carolina

Energy Technology Data Exchange (ETDEWEB)

Stephenson, K.; Crass, D.C.; Sassaman, K.E.

1993-02-01

Documented in this report are the methods and results of an intensive archaeological survey for the proposed University of Georgia Savannah River Ecology Laboratory (SREL) Conference Center and Educational Facility on the DOE Savannah River Site (SRS). Archaeological investigations conducted by the Savannah River Archaeological Research Program (SRARP) on the 70-acre project area and associated rights-of-way consisted of subsurface testing at two previously recorded sites and the discovery of one previously unrecorded site. The results show that 2 sites contain archaeological remains that may yield significant information about human occupations in the Aiken Plateau and are therefore considered eligible for nomination to the National Register of Historic Places. Adverse impacts to these sites can be mitigated through avoidance.

[Motorcycle accidents in the municipality of Rio Branco in the State of Acre: characterization and trends].

Science.gov (United States)

Rocha, Greiciane da Silva; Schor, Néia

2013-03-01

The scope of this paper is to assess traffic accidents involving motorcycles, the victims involved and the increase in the fleet compared with other vehicles in Rio Branco, State of Acre. It is an epidemiological, descriptive and transversal study of accidents between 2005 and 2008 recorded by the Acre State Highway Department. There were 3,582 motorcycle accidents and 3,768 victims in the period. The motorcycle fleet increased by 72.8%, with involvement in accidents increasing by 42.2%, while accidents involving other vehicles only increased by 9.2%. As regards victims, there is a predominance of men, with rates of 561.1, with the age groups of between 20 and 29 and 30 and 39 being the highest, with 755.4 and 542.2, respectively. With reference to accident characteristics, the highest number of accidents - 32.4% - occurred in the afternoon, followed by the morning with 29.2% and the evening with 28.9%. 18.3% occurred on Saturdays and 15.7% on Sundays. Collisions were the commonest kind of accident, with 3,036 (84.8%) occurrences. The conclusion drawn is that it is essential to stage ongoing preventive programs and ensure greater integration among the institutions involved, with planning and campaigns to reverse the current situation.

Mitigation and Monitoring Plan for impacted wetlands at the Gunnison UMTRA Project site, Gunnison, Colorado. Revision 1

International Nuclear Information System (INIS)

1994-12-01

The Gunnison, Colorado, abandoned uranium mill site is one site being cleaned up by the DOE under UMTRCA authority. This site's contaminated material is being transported to a disposal site on US Bureau of Land Management (BLM) land east of Gunnison. Remedial action activities have temporarily disturbed 0.8 acre (ac) (0.3 hectares [ha]) of wetlands and permanently eliminated 4.3 ac (1.7 ha). As required by the Clean Water Act, the US Army Corps of Engineers (USACE) prepared a Section 404 Permit that addresses the loss of wetlands as a result of remedial action at the Gunnison UMTRA Project site. The 404 permit includes this report as an attachment and it describes the wetland mitigation and monitoring plan. The DOE formulated this plan in consultation with the BLM and the USACE. This report represents a revised version of the mitigation and monitoring plan (DOE, 1992b)

Evaluation of the content and accessibility of web sites for accredited orthopaedic sports medicine fellowships.

Science.gov (United States)

Mulcahey, Mary K; Gosselin, Michelle M; Fadale, Paul D

2013-06-19

The Internet is a common source of information for orthopaedic residents applying for sports medicine fellowships, with the web sites of the American Orthopaedic Society for Sports Medicine (AOSSM) and the San Francisco Match serving as central databases. We sought to evaluate the web sites for accredited orthopaedic sports medicine fellowships with regard to content and accessibility. We reviewed the existing web sites of the ninety-five accredited orthopaedic sports medicine fellowships included in the AOSSM and San Francisco Match databases from February to March 2012. A Google search was performed to determine the overall accessibility of program web sites and to supplement information obtained from the AOSSM and San Francisco Match web sites. The study sample consisted of the eighty-seven programs whose web sites connected to information about the fellowship. Each web site was evaluated for its informational value. Of the ninety-five programs, fifty-one (54%) had links listed in the AOSSM database. Three (3%) of all accredited programs had web sites that were linked directly to information about the fellowship. Eighty-eight (93%) had links listed in the San Francisco Match database; however, only five (5%) had links that connected directly to information about the fellowship. Of the eighty-seven programs analyzed in our study, all eighty-seven web sites (100%) provided a description of the program and seventy-six web sites (87%) included information about the application process. Twenty-one web sites (24%) included a list of current fellows. Fifty-six web sites (64%) described the didactic instruction, seventy (80%) described team coverage responsibilities, forty-seven (54%) included a description of cases routinely performed by fellows, forty-one (47%) described the role of the fellow in seeing patients in the office, eleven (13%) included call responsibilities, and seventeen (20%) described a rotation schedule. Two Google searches identified direct links for

MOLECULAR CHARACTERIZATION OF AMERICAN CUTANEOUS LEISHMANIASIS IN THE TRI‑BORDER AREA OF ASSIS BRASIL, ACRE STATE, BRAZIL

Directory of Open Access Journals (Sweden)

Carolina Bioni Garcia TELES

2015-08-01

Full Text Available SUMMARY In this study, Leishmaniaspecies were identified by Polymerase Chain Reaction (PCR. The epidemiology of patients suspected of having American Cutaneous Leishmaniasis in the municipality of Assis Brasil, Acre State, located in the Brazil/Peru/Bolivia triborder was also investigated. By PCR, the DNA of Leishmaniawas detected in 100% of the cases (37 samples and a PCR-Restriction Fragment Length Polymorphism (RFLP of the hsp 70gene identified the species in 32 samples: Leishmania (Viannia braziliensis (65.6% , L. (V. shawi (28.1% , L. (V. guyanensis (3.1% and mixed infection L. (V. guyanensis and L. (Leishmania amazonensis (3.1%This is the first report of L. (V. shawiand L. (L. amazonensis in Acre. The two predominant species were found in patients living in urban and rural areas. Most cases were found in males living in rural areas for at least three years and involved in rural work. This suggests, in most cases, a possible transmission of the disease from a rural/forest source, although some patients had not engaged in activities associated with permanence in forestall areas, which indicate a possible sandflies adaptation to the periurban setting.

Wildflowers of the Savannah River Site

Energy Technology Data Exchange (ETDEWEB)

Seger, Tona [Savannah River Site (SRS), Aiken, SC (United States). USDA Forest Service

2015-08-01

This guidebook is a resource to help field personnel (nonbotanists) identify plants on the Savannah River Site (SRS) premises. Although not a complete flora guide, this publication contains information about 123 plant species found on the SRS. Plants are listed by their common names and arranged by the color of the flower. The SRS supports a diverse array of plant communities. Land use history, the establishment of the SRS, and current land management practices have shaped the flora presently found on the SRS. Located south of Aiken, SC, SRS spans 198,344 acres with land covering Aiken, Allendale, and Barnwell Counties. Situated on the Upper Coastal Plain and Sandhills physiographic provinces, the SRS has more than 50 distinct soil types. The topography is rolling to flat with elevation ranges from 50 to 400 feet above sea level.

77 FR 60139 - Draft Environmental Impact Statement for the Proposed Pueblo of Jemez 70.277-Acre Fee-to-Trust...

Science.gov (United States)

2012-10-02

... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Draft Environmental Impact Statement for the... all work on an Environmental Impact Statement (EIS) for the BIA Federal action of approving a 70.277 acre fee-to-trust transfer and casino project located within Do[ntilde]a Ana County, New Mexico. DATES...

Otite parasitária causada por Rhabditis (Rhabditis freitasi (Nematoda: Rhabditidae em animais da raça Gir no estado do Acre.

Directory of Open Access Journals (Sweden)

Francirley , Monteiro e Silva

2016-06-01

Full Text Available The bovine parasitic otitis has been reported in several states of Brazil. It is caused by rhabditiforms nematodes, attacking cattle Gir and Indubrasil breeds. The aim of this work was to describe the occurrence of the disease in animals of the cattle Gir breed in Rio Branco, State of Acre, Brazil. The animals belonged to the Station of Improvement and Animal Genetic Diffusion. Samples were collected from five of these individuals, with swabs aid, conditioned in plastic tubes and kept in alcohol 70%. The specimens were visualized using optical microscopy, and the morphometry was accomplished through a micrometrical ocular. The data were inserted in the Excel spreadsheet, running on Windows 7, and analyzed through descriptive statistics. The animals presented purulent secretion in the external ear canals, shook their heads, showed inquietude and sensibility to the touch during the clinical trials, when intense infestation was observed. One of the individuals died. Animal genetic improvement programs are negatively interfered by infestations like these. It was possible and opportune to find out the moment and place how such illness has entered in the state of Acre. This work aims to help reinforce the importance of future studies to report new cases in the state of Acre.

Integrating intrusive and nonintrusive characterization methods to achieve a conceptual site model for the SLDA FUSRAP site

International Nuclear Information System (INIS)

Durham, L.A.; Peterson, J.M.; Frothingham, D.G.; Frederick, W.T.; Lenart, W.

2008-01-01

The US Army Corps of Engineers (USACE) is addressing radiological contamination following Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) requirements at the Shallow Land Disposal Area (SLDA) site, which is a radiologically contaminated property that is part of the Formerly utilized Sites Remedial Action Program (FUSRAP). The SLDA is an 18-hectare (44-acre) site in Parks township, Armstrong County, Pennsylvania, about 37 kilometers (23 miles) east-northeast of Pittsburgh. According to historical record, radioactive wastes were disposed of at the SLDA in a series of trenches by the Nuclear Materials and Equipment Company (NUMEC) in the 1960s. The wastes originated from the nearby Apollo nuclear fuel fabrication facility, which began operations under NUMEC in the late 1950s and fabricated enriched uranium into naval reactor fuel elements. It is believed that the waste materials were buried in a series of pits constructed adjacent to one another in accordance with an Atomic Energy Commission (AEC) regulation that has since been rescinded. A CERCLA remedial investigation/feasibility study (RI/FS) process was completed for the SLDA site, and the results of the human health risk assessment indicated that the radiologically contaminated wastes could pose a risk to human health in the future. There are no historical records that provide the exact location of these pits. However, based on geophysical survey results conducted in the 1980s, these pits were defined by geophysical anomalies and were depicted on historical site drawings as trenches. At the SLDA site, a combination of investigative methods and tools was used in the RI/FS and site characterization activities. The SLDA site provides an excellent example of how historical documents and data, historical aerial photo analysis, physical sampling, and nonintrusive geophysical and gamma walkover surveys were used in combination to reduce the uncertainty in the location of the trenches. The

Measurement of superoxide dismutase-like activity in peel and pulp of apple from Anshan acres

Science.gov (United States)

Zhao, Lijuan

2018-04-01

Pyrogallol autoxidation method was used for measurement of SOD-like activity. They are 259.56 u/g and 148.78 u/g in peel and pulp of apple from Anshan acres. The proper-conditions for this measurement was determined through experiment as following: detection wavelength of spectrophotometer 325nm, buffer system Tris-HAc, concentration of Tris-HAc solution 50 mmoL and pH8.2. The inhibition rate of SOD-L again pyrogallol antioxidation are 92% and 90% in peel and pulp of apple.

Chemical Properties of Pore Water and Sediment at Three Wetland Sites Near the F- and H-Area Seepage Basins, Savannah River Site

Energy Technology Data Exchange (ETDEWEB)

Friday, G.P.

2001-05-15

In 1980, vegetative stress and arboreal mortality in wetland plant communities down-gradient from the F- and H-Area seepage basins were detected using aerial imagery. By 1988, approximately six acres in H-Area and four acres in F-Area had been adversely impacted. Today, wetland plant communities have become well established at the H-Area tree-kill zone.

Psychological risk factors of addiction to social networking site among Chinese smart phone users

OpenAIRE

Wu, Anise M. S.; Cheung, Vivi I.; Ku, L.; Hung, Eva P. W.

2013-01-01

Background and aims: Smartphones allow users to access social networking sites (SNSs) whenever and wherever they want. Such easy availability and accessibility may increase their vulnerability to addiction. Based on the social cognitive theory (SCT), we examined the impacts of outcome expectancies, self-efficacy, and impulsivity on young Chinese smartphone users' addictive tendencies toward SNSs. Methods: Two hundred seventy-seven Macau young smartphone users (116 males and 161 females; mean ...

Mastication: A fuel reduction and site preparation alternative

Science.gov (United States)

Jeff Halbrook; Han-Sup Han; Russell T. Graham; Theresa B. Jain; Robert Denner

2006-01-01

During the fall of 2005, a study was conducted at Priest River Experimental Forest (PREF) in northern Idaho to investigate the economics of mastication used to treat activity and standing live fuels. In this study, a rotary head masticator was used to crush and chop activity fuels within harvest units on 37.07 acres. Production averaged 0.57 acres/hour (range 0.21-0.89...

Work plan for the remedial investigation/feasibility study-environmental impact statement for the Weldon Spring site, Weldon Spring, Missouri

International Nuclear Information System (INIS)

Peterson, J.M.; MacDonell, M.M.; Haroun, L.A.; Nowadly, F.K.; Knight, W.C.; Vajda, G.F.

1988-08-01

The Weldon Spring Site Remedial Action Project is being conducted as a Major System Acquisition under the Surplus Facilities Management Program (SFMP) of the US Department of Energy (DOE). The major goals of the SFMP are to eliminate potential hazards to the public and the environment that are associated with contamination at SFMP sites and to make surplus real property available for other uses to the extent possible. The Weldon Spring site is located near Weldon Spring, Missouri, about 48 km (30 mi) west of St. Louis. It is surrounded by large tracts of land owned by the federal government and the state of Missouri. The site consists of four raffinate pits, an inactive chemical plant, and a contaminated quarry. The raffinate pits and chemical plant are on adjoining land about 3.2 km (2 mi) southwest of the junction of Missouri (State) Route 94 and US Route 40/61, with access from Route 94. The quarry is located in a comparatively remote area about 6.4 km (4 mi) south-southwest of the raffinate pits and chemical plant area; the quarry can also be accessed from Route 94. These areas are fenced and closed to the public. From 1941 to 1944, the US Department of the Army operated the Weldon Spring Ordnance Works, constructed on the land that is now the Weldon Spring site, for production of trinitrotoluene (TNT) and dinitrotoluene (DNT). The Army used the quarry for disposal of rubble contaminated with TNT. In the mid 1950s, 83 ha (205 acres) of the ordnance works property was transferred to the US Atomic Energy Commission (AEC); this is now the raffinate pits and chemical plant area. An additional 6 ha (15 acres) was later transferred to the AEC for expansion of waste storage capacity. 23 refs., 37 figs., 21 tabs

Impact of initial spacing on yield per acre and wood quality of unthinned loblolly pine at age 21

Science.gov (United States)

Alexander, III Clark; Richard F. Daniels; Lewis Jordan; Laurie Schimleck

2010-01-01

The market for southern pine first thinnings is soft. Thus, forest managers are planting at wider spacings, and using weed control and fertilization to grow chipping-saw and sawtimber trees in shorter rotations. A 21-year-old unthinned spacing study was sampled to determine the effect of initial spacing on wood quality and yield per acre of planted loblolly pine (

Formerly utilized MED/AEC sites, Remedial Action Program: radiological survey of the Hooker Chemical Company, Niagara Falls, New York. Final report

International Nuclear Information System (INIS)

1977-01-01

Results of a radiological survey of a portion of the Hooker Chemical Company, Niagara Falls, New York, are presented. The survey was conducted over 5.5-acres in which uranium-bearing materials were handled in the early 1940's. The survey included direct measurements of alpha, beta-gamma, and external gamma radiation throughout the site, measurement of transferable alpha and beta contamination levels in the buildings, determination of uranium and radium concentrations in the soild on the site, measurement of radon and radon daughter concentrations in the buildings, and determination of radionuclide concentrations in surface water samples. The results of the survey indicate that radiation levels throughout the site are within pertinent guidelines for unrestricted release of the property

Prevalence of and factors associated with overweight among university students from Rio Branco, Acre – Brazil

Directory of Open Access Journals (Sweden)

Gustavo de Souza Moretti

2014-05-01

The aim of this study was to determine the prevalence of and factors associated with overweight among university students from the city of Rio Branco, Acre, Brazil. A cross-sectional study was conducted on 1,104 students (mean age: 24 years from Rio Branco, Acre. Overweight was used as the dependent variable. The following independent variables were studied: socioeconomic variables (gender, age, teaching institution, period of study, marital status, income, household members, living with other people, parent’s education level, and working or not; self-reported health and morbidity variables (health perception, hypertension, diabetes, and altered cholesterol; lifestyle variables (physical activity, watching television, computer use, smoking, and alcohol consumption. The nutritional status was classified based on body mass index. Univariate analysis was performed using Pearson’s chi-squared test or Fisher’s exact test. Variables with a p value < 20% on univariate analysis were included in the multiple Poisson regression model. The prevalence of overweight was 35.6%. In the multiple regression model for male students adjusted for age, overweight was associated with marital status, household income, hypertension, and watching television every day. In the model for female students, the variables that remained associated were self-perceived health status, hypertension, and alcohol consumption in the last month. Overweight is determined by a combination of different factors which differed in the present study between men and women.

Baseline report - tall upland shrubland at the Rocky Flats Environmental Technology Site

International Nuclear Information System (INIS)

1997-03-01

Rocky Flats Environmental Technology Site (Site) is located on the Colorado Piedmont east of the Front Range between Boulder and Golden. At an elevation of approximately 6,000 feet, the Site contains a unique ecotonal mixture of mountain and prairie plant species, resulting from the topography and close proximity to the mountain front. The Buffer Zone surrounding the Industrial Area is one of the largest remaining undeveloped areas of its kind along the Colorado Piedmont. A number of plant communities at the Site have been identified as increasingly rare and unique by Site ecologists and the Colorado Natural Heritage Program (CNHP). These include the xeric tallgrass prairie, tall upland shrubland, wetlands, and Great Plains riparian woodland communities. Many of these communities support populations of increasingly rare animals as well, including the Preble's meadow jumping mouse, grasshopper sparrow, loggerhead shrike, Merriam's shrew, black crowned night heron, and Hops blue and Argos skipper butterflies. One of the more interesting and important plant communities at the Site is the tall upland shrubland community. It has been generally overlooked by previous Site ecological studies, probably due to its relatively small size; only 34 acres total. Although mentioned in a plant community ordination study conducted by Clark et al. and also in the Site baseline ecological study, few data were available on this plant community before the present study

Baseline report - tall upland shrubland at the Rocky Flats Environmental Technology Site

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-03-01

Rocky Flats Environmental Technology Site (Site) is located on the Colorado Piedmont east of the Front Range between Boulder and Golden. At an elevation of approximately 6,000 feet, the Site contains a unique ecotonal mixture of mountain and prairie plant species, resulting from the topography and close proximity to the mountain front. The Buffer Zone surrounding the Industrial Area is one of the largest remaining undeveloped areas of its kind along the Colorado Piedmont. A number of plant communities at the Site have been identified as increasingly rare and unique by Site ecologists and the Colorado Natural Heritage Program (CNHP). These include the xeric tallgrass prairie, tall upland shrubland, wetlands, and Great Plains riparian woodland communities. Many of these communities support populations of increasingly rare animals as well, including the Preble`s meadow jumping mouse, grasshopper sparrow, loggerhead shrike, Merriam`s shrew, black crowned night heron, and Hops blue and Argos skipper butterflies. One of the more interesting and important plant communities at the Site is the tall upland shrubland community. It has been generally overlooked by previous Site ecological studies, probably due to its relatively small size; only 34 acres total. Although mentioned in a plant community ordination study conducted by Clark et al. and also in the Site baseline ecological study, few data were available on this plant community before the present study.

Plant remains of archaeological site Casa Vieja, Callango (Ica

Directory of Open Access Journals (Sweden)

José Roque

2013-06-01

Full Text Available A paleoethnobotanical study was carried out at the Middle Horizon archaeological site of Casa Vieja, located in Callango within the Lower Ica Valley. A total of 23 species were identified, all determined to be of the Magnoliopyta Division, 78 % (or 18 species were Magnoliopsid and 22% (or 15 species Liliopsid. The Fabaceae are the best represented family with 6 species. Most of the analyzed samples correspond to seeds of Gossypium barbadense “cotton”. Seventy percent of the species were probably used as food; 48% for artifact-making and construction and 52% for medicinal and curative purposes.

Superfund Record of Decision (EPA Region 2): Sinclair Refinery, Allegany County, Wellsville, NY. (Second remedial action), September 1991. Final report

International Nuclear Information System (INIS)

1991-01-01

The Sinclair Refinery site is a former refinery in Wellsville, Allegany County, New York. The site is composed of a 90-acre refinery area, 10-acre landfill area, and 14-acre offsite tank farm. From 1901 to 1958, the site was used to process Pennsylvania grade crude oil until a fire in 1958 halted operations. Currently, some private companies and the State University of New York occupy the site. A 1981 site inspection revealed that debris from the eroding landfill area has washed into and contaminated the Genesee River. The ROD addresses OU2, remediation of the remaining contaminated areas at the site located within the 90-acre refinery area and the offsite tank farm including the contaminated ground water beneath the refinery. The primary contaminants of concern affecting the soil and ground water are VOCs including benzene and xylenes, semi-volatile compounds including naphthalene and nitrobenzene, and metals including arsenic and lead. The selected remedial action for the site is included

Niagara Falls Storage Site environmental surveillance report for calendar year 1993

International Nuclear Information System (INIS)

1994-06-01

This report summarizes the results of environmental surveillance activities conducted at the Niagara Falls Storage Site (NFSS) during calendar year 1993. It includes an overview of site operations, the basis for radiological and nonradiological monitoring, a summary of the results, and the estimated dose to the offsite population. Environmental surveillance activities were conducted in accordance with the site environmental monitoring plan, which describes the rationale and design criteria for the surveillance program, the frequency of sampling and analysis, specific sampling and analysis procedures, and quality assurance requirements. NFSS is in compliance with National Emission Standards for Hazardous Air Pollutants (NESHAPs) Subpart H of the Clean Air Act as well as the requirements of the National Pollutant Discharge Elimination System (NPDES) under the Clean Water Act. Located in northwestern New York, the site covers 191 acres. From 1944 to the present, the primary use of NFSS has been storage of radioactive residues that were by-products of uranium production. Most onsite areas of residual radioactivity above regulatory guidelines were remediated during the early 1980s. Additional isolated areas of onsite contamination were remediated in 1989, and the materials were consolidated into the waste containment structure in 1991. Remediation of the site has now been completed

Keratella lenzi (Hauer, 1953: a new occurrence for Acre State, Brazil, specifically in Igarapé Jesumira located in Parque Nacional da Serra do Divisor

Directory of Open Access Journals (Sweden)

Erlei Cassiano Keppeler

2010-04-01

Full Text Available http://dx.doi.org/10.5007/2175-7925.2010v23n2p219 Keratella lenzi (Hauer, 1953: uma nova ocorrência no estado do Acre, Brasil, especificamente no Igarapé Jesumira localizado no Parque Nacional da Serra do Divisor. Rotíferos são importantes componentes do plâncton de águas continentais e, ocupam o nicho ecológico de pequenos filtradores. A ampla distribuição deste grupo em planícies de inundação deve-se ao fato de sua tolerância às mudanças ambientais, causadas especialmente pelas águas altas e, por conseguinte diversificação dos nichos. Todavia, a biodiversidade destes ambientes ainda é desconhecida, especialmente no Noroeste do Estado do Acre. Os organismos foram coletados usando rede de plâncton com malha de abertura de 50μm e, conservados em solução de formol a concentração de 4%. Este trabalho registrou a primeira ocorrência de Keratella lenzi no Estado do Acre, identificada nas amostras de plâncton do Igarapé Jesumira (7º28’10,2”S e 73º33’54,6”.

Nuclear method applied in archaeological sites at the Amazon basin

International Nuclear Information System (INIS)

Nicoli, Ieda Gomes; Bernedo, Alfredo Victor Bellido; Latini, Rose Mary

2002-01-01

The aim of this work was to use the nuclear methodology to character pottery discovered inside archaeological sites recognized with circular earth structure in Acre State - Brazil which may contribute to the research in the reconstruction of part of the pre-history of the Amazonic Basin. The sites are located mainly in the Hydrographic Basin of High Purus River. Three of them were strategic chosen to collect the ceramics: Lobao, in Sena Madureira County at north; Alto Alegre in Rio Branco County at east and Xipamanu I, in Xapuri County at south. Neutron Activation Analysis in conjunction with multivariate statistical methods were used for the ceramic characterization and classification. An homogeneous group was established by all the sherds collected from Alto Alegre and was distinct from the other two groups analyzed. Some of the sherds collected from Xipamunu I appeared in Lobao's urns, probably because they had the same fabrication process. (author)

Post-Closure Inspection, Sampling, and Maintenance Report for the Salmon, Mississippi, Site Calendar Year 2012

Energy Technology Data Exchange (ETDEWEB)

None

2013-03-01

This report summarizes the 2012 annual inspection, sampling, measurement, and maintenance activities performed at the Salmon, Mississippi, Site (Salmon site). The draft Long-Term Surveillance and Maintenance Plan for the Salmon Site, Lamar County, Mississippi (DOE 2007) specifies the submittal of an annual report of site activities with the results of sample analyses. A revised plan is in preparation. The Long-Term Surveillance Plan for the Salmon, Mississippi, Site is intended for release in 2013. The Salmon site consists of 1,470 acres. The site is located in Lamar County, Mississippi, approximately 10 miles west of Purvis, Mississippi, and about 21 miles southwest of Hattiesburg, Mississippi The State of Mississippi owns the surface real estate subject to certain restrictions related to subsurface penetration. The State is the surface operator; the Mississippi Forestry Commission is its agent. The federal government owns the subsurface real estate (including minerals and some surface features), shares right-of-entry easements with the State, and retains rights related to subsurface monitoring. The U.S. Department of Energy (DOE) Office of Legacy Management (LM), a successor agency to the U.S. Atomic Energy Commission, is responsible for the long-term surveillance of the subsurface real estate

Post-Closure Inspection, Sampling, and Maintenance Report for the Salmon, Mississippi, Site Calendar Year 2012

International Nuclear Information System (INIS)

2013-01-01

This report summarizes the 2012 annual inspection, sampling, measurement, and maintenance activities performed at the Salmon, Mississippi, Site (Salmon site). The draft Long-Term Surveillance and Maintenance Plan for the Salmon Site, Lamar County, Mississippi (DOE 2007) specifies the submittal of an annual report of site activities with the results of sample analyses. A revised plan is in preparation. The Long-Term Surveillance Plan for the Salmon, Mississippi, Site is intended for release in 2013. The Salmon site consists of 1,470 acres. The site is located in Lamar County, Mississippi, approximately 10 miles west of Purvis, Mississippi, and about 21 miles southwest of Hattiesburg, Mississippi The State of Mississippi owns the surface real estate subject to certain restrictions related to subsurface penetration. The State is the surface operator; the Mississippi Forestry Commission is its agent. The federal government owns the subsurface real estate (including minerals and some surface features), shares right-of-entry easements with the State, and retains rights related to subsurface monitoring. The U.S. Department of Energy (DOE) Office of Legacy Management (LM), a successor agency to the U.S. Atomic Energy Commission, is responsible for the long-term surveillance of the subsurface real estate.

Serpentes peçonhentas e ofidismo em Cruzeiro do Sul, Alto Juruá, Estado do Acre, Brasil Venomous snakes and ophidism in Cruzeiro do Sul, Alto Juruá, State of Acre, Brazil

Directory of Open Access Journals (Sweden)

Paulo Sérgio Bernarde

2012-03-01

Full Text Available Apesar da importância dos acidentes ofídicos na Saúde Pública, são relativamente poucas as pesquisas realizadas sobre esse tema no Brasil. Devido aos poucos estudos sobre ofidismo na Amazônia e especialmente no estado do Acre, trabalhos epidemiológicos são de grande relevância. Esse estudo apresenta a lista de serpentes peçonhentas e aspectos epidemiológicos dos acidentes ofídicos em Cruzeiro do Sul, região do Alto Juruá (Acre, verificando quais gêneros de serpentes são responsáveis pelos envenenamentos e aspectos que envolvem o acidente e o atendimento hospitalar. Os dados epidemiológicos foram coligidos a partir do SINAN (Sistema de Informações de Agravos de Notificação, no setor de vigilância epidemiológica do Hospital Regional do Juruá, no município de Cruzeiro do Sul. Sete espécies de serpentes peçonhentas foram registradas nesse município: três viperídeos (Bothrops atrox, Bothriopsis bilineata e Lachesis muta e quatro elapídeos (Micrurus hemprichii, M. lemniscatus, M. remotus and M. surinamensis. Durante o período de dois anos (agosto de 2007 a julho de 2009 foram registrados 195 casos de acidentes ofídicos. Cinquenta e um por cento dos acidentes foi classificado como laquético (Lachesis, seguido pelo botrópico (Bothrops e Bothriopsis com 38% e crotálico (Crotalus com 2%. Em 9% dos casos o gênero da serpente envolvida não foi informado. A maioria dos acidentes envolveu indivíduos adultos do gênero masculino em área rural, afetados principalmente nos membros inferiores. Os casos ocorreram mais frequentemente nos meses de novembro a abril, coincidindo com os maiores níveis pluviométricos. A maioria dos acidentes foi atribuída equivocadamente à serpente L. muta, tendo sido provavelmente causados por B. atrox.Despite the importance of accidents involving snakebites, research on this theme in Brazil is relatively rare, especially in the Amazon region. Due to the poor number of studies about ophidism

Avian use of proposed KENETECH and CARES wind farm sites in Klickitat County, Washington: Technical report. Appendix D

International Nuclear Information System (INIS)

1995-01-01

The Columbia Hills area above (north of) the Columbia River in Klickitat County, in southcentral Washington, is being considered for development of two wind power generation projects that could include the eventual placement of up to 436 wind turbines. The KENETECH Windpower Washington Windplant trademark Number 1 project would include placing up to 345 KENETECH 33M-VS turbines, capable of producing up to 115 megawatts (MW), in 39 rows (strings) on a 5,110-hectare (12,630-acre) site. The Conservation and Renewable Energy Systems (CARES) Columbia Wind Farm number-sign 1 project would include placing 91 Flowind AWT-26 turbines, capable of generating 25 MW, in 11 rows on a 395-hectare (975-acre) site. During scoping for these proposed developments, concerns were raised regarding the potential for avian mortality associated with wind farm development. Collision with wind turbine blade, towers, guy wires, and transmission lines, and electrocution from power lines have been identified as sources of avian mortality, particularly raptors, at existing wind farm facilities. To address these concerns, an avian study was conducted at the site in accordance with an avian study plan and protocol developed, with input from a national avian task force, state agencies (Washington Department of Fish and Wildlife [WDFW]), and federal agencies (USFWS). The study included four elements: (1) a winter raptor and waterfowl study, (2) spring migration and fall migration studies, (3) a summer resident study, and (4) a raptor breeding study. The study involved extensive field studies conducted by biologists experienced in identifying raptors and other birds

Taxonomia de solos desenvolvidos sobre depósitos sedimentares da Formação Solimões no Estado do Acre Taxonomy of soils developed under sedimentary deposits from Solimões Formation in Acre state, Brazil

Directory of Open Access Journals (Sweden)

Thiago de Andrade Bernini

2013-01-01

Full Text Available Os solos do Estado do Acre na maioria são formados sobre material de origem com grande influência da orogênese Andina, com elevados teores de Ca2+, Mg2+ e Al3+ concomitantemente, associado às combinações diferenciadas dos valores da CTC, V e m. O objetivo deste trabalho foi caracterizar e classificar os solos de uma topossequência sobre material sedimentar da Formação Solimões, no município de Feijó, Acre. Foram abertas trincheiras em três pontos de uma topossequência: terço superior (P1, terço médio (P2 e terço inferior (P3. Os solos foram analisados quanto a morfologia, granulometria (areia, silte e argila, complexo sortivo (Ca2+, Mg2+, Na+, K+ e Al3+, acidez potencial (H+Al, P assimilável, pH (água e KCl, superfície específica, ataque sulfúrico (óxidos de Fe, Al, Ti e Si, mineralogia (frações areia, silte e argila. Os solos foram classificados segundo o Sistema Brasileiro de Classificação de Solos (SiBCS, 2006 e apresentada uma proposta de classificação considerando as peculiaridades do solos da região. Os solos têm baixo grau de desenvolvimento pedogenético, com minerais da fração argila de alta atividade, além da presença de minerais primários, como feldspatos e plagioclásios, nas frações areia e silte. Os solos foram classificados segundo o SiBCS atual como Argissolo Vermelho Álitico plíntico (P1, Argissolo Acinzentado Distrófico plíntico (P2 e Cambissolo Háplico Ta Eutrófico típico (P3.The soils from the State of Acre (Brazil are mostly formed under parent material with influence of Andean orogeny, showing high Ca2+, Mg2+and Al3+ contents concomitantly associated with different combinations of CEC, V and m values. This study aimed to characterize and classify soils of a topossequence under sedimentary material from Solimões Formation, in the county of Feijó, State of Acre, Brazil. Trenches were opened in three points on a topossequence: shoulder (P1, backslope (P2 and footslope (P3. The

SU-F-R-30: Interscanner Variability of Radiomics Features in Computed Tomography (CT) Using a Standard ACR Phantom

Energy Technology Data Exchange (ETDEWEB)

Shafiq ul Hassan, M; Zhang, G; Moros, E [H Lee Moffitt Cancer Center and Research Institute, Tampa, FL (United States); Department of Physics, University of South Florida, Tampa, FL (United States); Budzevich, M; Latifi, K; Hunt, D; Gillies, R [H Lee Moffitt Cancer Center and Research Institute, Tampa, FL (United States)

2016-06-15

Purpose: A simple approach to investigate Interscanner variability of Radiomics features in computed tomography (CT) using a standard ACR phantom. Methods: The standard ACR phantom was scanned on CT scanners from three different manufacturers. Scanning parameters of 120 KVp, 200 mA were used while slice thickness of 3.0 mm on two scanners and 3.27 mm on third scanner was used. Three spherical regions of interest (ROI) from water, medium density and high density inserts were contoured. Ninety four Radiomics features were extracted using an in-house program. These features include shape (11), intensity (22), GLCM (26), GLZSM (11), RLM (11), and NGTDM (5) and 8 fractal dimensions features. To evaluate the Interscanner variability across three scanners, a coefficient of variation (COV) is calculated for each feature group. Each group is further classified according to the COV- by calculating the percentage of features in each of the following categories: COV less than 2%, between 2 and 10% and greater than 10%. Results: For all feature groups, similar trend was observed for three different inserts. Shape features were the most robust for all scanners as expected. 70% of the shape features had COV <2%. For intensity feature group, 2% COV varied from 9 to 32% for three scanners. All features in four groups GLCM, GLZSM, RLM and NGTDM were found to have Interscanner variability ≥2%. The fractal dimensions dependence for medium and high density inserts were similar while it was different for water inserts. Conclusion: We concluded that even for similar scanning conditions, Interscanner variability across different scanners was significant. The texture features based on GLCM, GLZSM, RLM and NGTDM are highly scanner dependent. Since the inserts of the ACR Phantom are not heterogeneous in HU values suggests that matrix based 2nd order features are highly affected by variation in noise. Research partly funded by NIH/NCI R01CA190105-01.

Impacto da Educação na Renda das Famílias Rurais da Amazônia: Uma Análise a Partir da Agricultura Familiar no Acre.

Directory of Open Access Journals (Sweden)

Francisco Dietima da Silva Bezerra

2014-10-01

Full Text Available No Brasil, tem se observado nas últimas décadas, a persistência de um quadro histórico de alta desigualdade de renda que têm contribuindo para que o país seja considerado como uma das nações mais desiguais do planeta. Dentre os fatores que têm contribuído para manter as disparidades de rendimentos em patamares tão elevados, destaca-se a heterogeneidade educacional, principalmente no meio rural. Diante da importância do tema tratado, a presente pesquisa consiste em analisar o impacto da educação no desempenho econômico das famílias rurais do Estado do Acre. Utiliza-se a metodologia do projeto de pesquisa Análise Socioeconômica dos Sistemas de Produção Familiar no Estado do Acre (ASPF, desenvolvido pelo Centro de Ciências Jurídicas e Sociais Aplicadas (CCJSA da Universidade Federal do Acre (UFAC, a partir de indicadores de resultado econômico e medidas de relação. Os resultados indicam que no Vale do Acre o nível de escolaridade influencia significativamente no desempenho econômico das famílias analisadas, diferentemente do Vale do Juruá, em que o desempenho econômico tem menor relação com a escolaridade das famílias e é mais fortemente condicionado por outros fatores estruturais e/ou de mercado.

ACR-SNM Task Force on Nuclear Medicine Training: report of the task force.

Science.gov (United States)

Guiberteau, Milton J; Graham, Michael M

2011-06-01

The expansion of knowledge and technological advances in nuclear medicine and radiology require physicians to have more expertise in functional and anatomic imaging. The convergence of these two specialties into the new discipline of molecular imaging has also begun to place demands on residency training programs for additional instruction in physiology and molecular biology. These changes have unmasked weaknesses in current nuclear medicine and radiology training programs. Adding to the impetus for change are the attendant realities of the job market and uncertain employment prospects for physicians trained in nuclear medicine but not also trained in diagnostic radiology. With this background, the ACR and the Society of Nuclear Medicine convened the Task Force on Nuclear Medicine Training to define the issues and develop recommendations for resident training.

The Evolution of LTS at DOE's Hanford Site

International Nuclear Information System (INIS)

Moren, Richard J.; Grindstaff, Keith D.

2013-01-01

Hanford's Long-Term Stewardship (LTS) Program has evolved from a small, informal process, with minimal support, to a robust program that provides comprehensive transitions from cleanup contractors to long-term stewardship for post-cleanup requirements specified in the associated cleanup decision documents. The LTS Program has the responsibility for almost 100,000 acres of land, along with over 200 waste sites and will soon have six cocooned reactors. Close to 2,600 documents have been identified and tagged for storage in the LTS document library. The program has successfully completed six consecutive transitions over the last two years in support of the U.S. DOE Richland Operations Office's (DOE-RL) near-term cleanup objectives of significantly reducing the footprint of active cleanup operations for the River Corridor. The program has evolved from one that was initially responsible for defining and measuring Institutional Controls for the Hanford Site, to a comprehensive, post remediation surveillance and maintenance program that begins early in the transition process. In 2013, the first reactor area -- the cocooned 105-F Reactor and its surrounding 1,100 acres, called the F Area was transitioned. In another first, the program is expected to transition the five remaining cocooned reactors into the program through using a Transition and Turnover Package (TTP). As Hanford's LTS Program moves into the next few years, it will continue to build on a collaborative approach. The program has built strong relationships between contractors, regulators, tribes and stakeholders and with the U.S. Department of Energy's Office of Legacy Management (LM). The LTS Program has been working with LM since its inception. The transition process utilized LM's Site Transition Framework as one of the initial requirement documents and the Hanford Program continues to collaborate with LM today. One example of this collaboration is the development of the LTS Program's records management

4 September 2015 - Signature of the guest book by Ambassador Oh Joon, Seventy-first President, United Nations Economic and Social Council (ECOSOC), Ambassador and Permanent Representative of the Republic of Korea to the United Nations in New York with Director for Administration and General infrastructure S. Lettow.

CERN Multimedia

Gadmer, Jean-Claude Robert

2015-01-01

4 September 2015 - Signature of the guest book by Ambassador Oh Joon, Seventy-first President, United Nations Economic and Social Council (ECOSOC), Ambassador and Permanent Representative of the Republic of Korea to the United Nations in New York with Director for Administration and General infrastructure S. Lettow. Also present: Head of IT Department F. Hemmer with E. Bjorgo and F. Pisano visiting the UNITAR’s operational satellite applications programme on CERN site in building 597. The delegation is accompanied throughout by Adviser to the Director-General, in charge of Relations with International Organisations M. Bona.

Phytoremediation of arsenic from the contaminated soil using transgenic tobacco plants expressing ACR2 gene of Arabidopsis thaliana.

Science.gov (United States)

Nahar, Noor; Rahman, Aminur; Nawani, Neelu N; Ghosh, Sibdas; Mandal, Abul

2017-11-01

We have cloned, characterized and transformed the AtACR2 gene (arsenic reductase 2) of Arabidopsis thaliana into the genome of tobacco (Nicotiana tabacum, var Sumsun). Our results revealed that the transgenic tobacco plants are more tolerant to arsenic than the wild type ones. These plants can grow on culture medium containing 200μM arsenate, whereas the wild type can barely survive under this condition. Furthermore, when exposed to 100μM arsenate for 35days the amount of arsenic accumulated in the shoots of transgenic plants was significantly lower (28μg/g d wt.) than that found in the shoots of non-transgenic controls (40μg/g d wt.). However, the arsenic content in the roots of transgenic plants was significantly higher (2400μg/g d. wt.) than that (2100μg/g d. wt.) observed in roots of wild type plants. We have demonstrated that Arabidopsis thaliana AtACR2 gene is a potential candidate for genetic engineering of plants to develop new crop cultivars that can be grown on arsenic contaminated fields to reduce arsenic content of the soil and can become a source of food containing no arsenic or exhibiting substantially reduced amount of this metalloid. Copyright © 2017 Elsevier GmbH. All rights reserved.

Remedial action selection report Maybell, Colorado, site. Final report

International Nuclear Information System (INIS)

1996-12-01

The Maybell uranium mill tailings site is 25 miles (mi) (40 kilometers [km]) west of the town of Craig, Colorado, in Moffat County, in the northwestern part of the state. The unincorporated town of Maybell is 5 road mi (8 km) southwest of the site. The site is 2.5 mi (4 km) northeast of the Yampa River on relatively flat terrain broken by low, flat-topped mesas. U.S. Highway 40 runs east-west 2 mi (3.2 km) south of the site. The designated site covers approximately 110 acres (ac) (45 hectares [ha]) and consists of a concave-shaped tailings pile and rubble from the demolition of the mill buildings buried in the former mill area. The site is situated between Johnson Wash to the east and Rob Pit Mine to the west. Numerous reclaimed and unreclaimed mines are in the immediate vicinity. Aerial photographs (included at the end of this executive summary) show evidence of mining activity around the Maybell site. Contaminated materials at the Maybell processing site include the tailings pile, which has an average depth of 20 feet (ft) (6 meters [ml]) and contains 2.8 million cubic yards (yd 3 ) (2.1 million cubic meters [m 3 ]) of tailings. The former mill processing area is on the north side of the site and contains 20,000 yd 3 (15,000 m 3 ) of contaminated demolition debris. Off-pile contamination is present and includes areas adjacent to the tailings pile, as well as contamination dispersed by wind and surface water flow. The volume of off-pile contamination to be placed in the disposal cell is 550,000 yd 3 (420,000 m 3 ). The total volume of contaminated materials to be disposed of as part of the remedial action is estimated to be 3.37 million yd 3 (2.58 million m 3 )

78 FR 8492 - Foreign-Trade Zone 84-Houston, TX Application for Expansion

Science.gov (United States)

2013-02-06

..., industrial parks and warehouse facilities in Houston and the Harris County area. The sites--which are in Houston unless otherwise stated--are as follows: Site 1 (421 acres)--Houston Ship Channel Turning Basin, Clinton Drive at Highway 610 East Loop; Site 2 (97 acres)--Houston Ship Channel (Bulk Materials Handling...

Heterotrophic components of soil respiration in pastures and forests in southwestern Amazonia, Acre, Brazil

Directory of Open Access Journals (Sweden)

Eric Atlas Davidson

2008-12-01

Full Text Available In this paper we present data on soil microbial biomass and heterotrophic respiration in pastures, mature and secondary forests, in order to elucidate their contribution to total CO2 flux from soil to atmosphere. The research was conducted in Southwestern Amazonia, Acre State, Brazil. Microbial biomass was estimated using a variation of the traditional fumigation-extraction method and heterotrophic respiration was measured using respirometry flasks attached to an infrared gas analyzer. Soil microbial biomass and heterotrophic respiration did not differ statistically among pastures, mature and secondary forests. These laboratory results indicate that higher CO2 fluxes from pasture soils measured in situ are probably due to higher root respiration by pasture grasses.

Detection of the pandemic norovirus variant GII.4 Sydney 2012 in Rio Branco, state of Acre, northern Brazil

Directory of Open Access Journals (Sweden)

Luciana Damascena da Silva

2013-12-01

Full Text Available Noroviruses (NoVs are important cause of gastroenteritis in humans worldwide. Genotype GII.4 is responsible for the majority of outbreaks reported to date. This study describes, for the first time in Brazil, the circulation of NoV GII.4 variant Sydney 2012 in faecal samples collected from children aged less than or equal to eight years in Rio Branco, state of Acre, northern Brazil, during July-September 2012.

Hazelwood Interim Storage Site environmental report for calendar year 1992, 9200 Latty Avenue, Hazelwood, Missouri

International Nuclear Information System (INIS)

1993-05-01

This report describes the environmental surveillance program at the Hazelwood Interim storage Site (HISS) and surrounding area, provides the results for 1992, and discusses applicable environmental standards and requirements with which the results were compared. HISS is located in eastern Missouri in the City of Hazelwood (St. Louis County) and occupies approximately 2.2 ha (5.5 acres). Environmental monitoring of HISS began in 1984 when the site was assigned to the US Department of Energy (DOE) as part of the decontamination research and development project authorized by Congress under the 1984 Energy and Water Development Appropriations Act. DOE placed responsibility for HISS under the Formerly Utilized Sites Remedial Action Program (FUSRAP), which was established to identify and decontaminate or otherwise control sites where residual radioactive materials remain from the early years of the nation's atomic energy program or from commercial operations causing conditions that Congress has authorized DOE to remedy. In 1992 there were no environmental occurrences or unplanned contaminant releases as defined in DOE requirements and in the Superfund Amendment and Reauthorization Act (SARA) Title III of CERCLA

Hazelwood Interim Storage Site environmental report for calendar year 1992, 9200 Latty Avenue, Hazelwood, Missouri

Energy Technology Data Exchange (ETDEWEB)

1993-05-01

This report describes the environmental surveillance program at the Hazelwood Interim storage Site (HISS) and surrounding area, provides the results for 1992, and discusses applicable environmental standards and requirements with which the results were compared. HISS is located in eastern Missouri in the City of Hazelwood (St. Louis County) and occupies approximately 2.2 ha (5.5 acres). Environmental monitoring of HISS began in 1984 when the site was assigned to the US Department of Energy (DOE) as part of the decontamination research and development project authorized by Congress under the 1984 Energy and Water Development Appropriations Act. DOE placed responsibility for HISS under the Formerly Utilized Sites Remedial Action Program (FUSRAP), which was established to identify and decontaminate or otherwise control sites where residual radioactive materials remain from the early years of the nation`s atomic energy program or from commercial operations causing conditions that Congress has authorized DOE to remedy. In 1992 there were no environmental occurrences or unplanned contaminant releases as defined in DOE requirements and in the Superfund Amendment and Reauthorization Act (SARA) Title III of CERCLA.

Soil Characterization at the Linde FUSRAP Site and the Impact on Soil Volume Estimates

International Nuclear Information System (INIS)

Boyle, J.; Kenna, T.; Pilon, R.

2002-01-01

The former Linde site in Tonawanda, New York is currently undergoing active remediation of Manhattan Engineering District's radiological contamination. This remediation is authorized under the Formerly Utilized Sites Remedial Action Program (FUSRAP). The focus of this paper will be to describe the impact of soil characterization efforts as they relate to soil volume estimates and project cost estimates. An additional objective is to stimulate discussion about other characterization and modeling technologies, and to provide a ''Lessons Learned'' scenario to assist in future volume estimating at other FUSRAP sites. Initial soil characterization efforts at the Linde FUSRAP site in areas known to be contaminated or suspected to be contaminated were presented in the Remedial Investigation Report for the Tonawanda Site, dated February 1993. Results of those initial characterization efforts were the basis for soil volume estimates that were used to estimate and negotiate the current remediation contract. During the course of remediation, previously unidentified areas of contamination were discovered, and additional characterization was initiated. Additional test pit and geoprobe samples were obtained at over 500 locations, bringing the total to over 800 sample locations at the 135-acre site. New data continues to be collected on a routine basis during ongoing remedial actions

Multivariate approach to assessing ecotoxicity on abandoned oil refinery environments: Study site description

International Nuclear Information System (INIS)

Lochmiller, R.L.; Yates, G.W.

1993-01-01

Ecology risk assessment requires a clear understanding of how complex mixtures of environmental contaminants impact terrestrial ecosystems. This assessment process could be more universally applied to terrestrial ecosystems with better defined assay systems for evaluating impacts of exposure on organisms, populations, and communities. The authors objective was to define and assess the efficacy of a battery of assays incorporating both standard biological toxicity test and in situ biomonitors for evaluating ecological risks on terrestrial environments contaminated with complex mixtures of petrochemicals on a 160 acre abandoned oil refinery in central Oklahoma. Three suspected contaminated and three uncontaminated reference sites were selected for intensive study. Habitat on each study site is representative of disturbed tall-grass prairie and supports dense, diverse small mammal communities. Soil samples were subjected to aqueous extraction and resulting leachates analyzed for heavy metals, selected ions, and organics. Analytical results support their initial assessment that toxic study sites were contaminated with complex mixtures including lead, zinc, arsenic, chloride, sulfate, potassium, and complex mixtures of polar and non-polar organics

Targeted Health Assessment for Wastes Contained at the Niagara Falls Storage Site to Guide Planning for Remedial Action Alternatives - 13428

Energy Technology Data Exchange (ETDEWEB)

Busse, John; Keil, Karen; Staten, Jane; Miller, Neil; Barker, Michelle [U.S. Army Corps of Engineers, Buffalo District, 1776 Niagara Street, Buffalo, NY (United States); MacDonell, Margaret; Peterson, John; Chang, Young-Soo; Durham, Lisa [Argonne National Laboratory, Environmental Science Division, 9700 S. Cass Ave., Argonne, IL 60439 (United States)

2013-07-01

The U.S. Army Corps of Engineers (USACE) is evaluating potential remedial alternatives at the 191-acre Niagara Falls Storage Site (NFSS) in Lewiston, New York, under the Formerly Utilized Sites Remedial Action Program (FUSRAP). The Manhattan Engineer District (MED) and Atomic Energy Commission (AEC) brought radioactive wastes to the site during the 1940's and 1950's, and the U.S. Department of Energy (US DOE) consolidated these wastes into a 10-acre interim waste containment structure (IWCS) in the southwest portion of the site during the 1980's. The USACE is evaluating remedial alternatives for radioactive waste contained within the IWCS at the NFSS under the Feasibility Study phase of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) process. A preliminary evaluation of the IWCS has been conducted to assess potential airborne releases associated with uncovered wastes, particularly during waste excavation, as well as direct exposures to uncovered wastes. Key technical issues for this assessment include: (1) limitations in waste characterization data; (2) representative receptors and exposure routes; (3) estimates of contaminant emissions at an early stage of the evaluation process; (4) consideration of candidate meteorological data and air dispersion modeling approaches; and (5) estimates of health effects from potential exposures to both radionuclides and chemicals that account for recent updates of exposure and toxicity factors. Results of this preliminary health risk assessment indicate if the wastes were uncovered and someone stayed at the IWCS for a number of days to weeks, substantial doses and serious health effects could be incurred. Current controls prevent such exposures, and the controls that would be applied to protect onsite workers during remedial action at the IWCS would also effectively protect the public nearby. This evaluation provides framing context for the upcoming development and detailed

Energetic particles beyond the heliospheric shock: Anomalous Cosmic Rays (ACRs), Pick-Up Ions (PUIs) and the associated energetic neutral atoms (ENAs)

International Nuclear Information System (INIS)

Fichtner, Horst; Czechowski, Andrzej; Fahr, Hans J.; Lay, Guenter

2000-01-01

The Voyager 1 spacecraft is expected to encounter the heliospheric termination shock within the next decade. Besides the ongoing discussion how to possibly predict the time of this encounter, there is a growing interest into a more detailed description of the region beyond the heliospheric shock, i.e., the heliosheath. Refinements of the so far rather crude models will facilitate interpretation of forthcoming data. We report on results obtained with our model of the transport of ACRs in the heliosheath. In improvement of earlier approaches it is based on a solar wind background flow computed with a self-consistent large-scale model of the heliosphere. Besides these downstream ACR spectra, which will become accessible for in situ observation as soon as the Voyager spacecraft will have crossed the heliospheric shock, we study the potential of observations of the flux of ENAs to remotely explore the structure of the heliosheath. In particular, as part of a comparison of the various ENA sources, we will address the significance of the contribution of those ENAs resulting from a de-charging of PUIs

Ambiente, saúde e trabalho: temas geradores para ensino em saúde e segurança do trabalho no Acre, Brasil

Directory of Open Access Journals (Sweden)

Josina Maria Pontes Ribeiro

Full Text Available O artigo apresenta ambiente, saúde e trabalho como temas geradores necessários à construção de uma tecnologia social para educação profissional, considerando a ergologia como perspectiva de análise, e, o diálogo, como estratégia de ensino em Saúde e Segurança no Trabalho para Agentes de Combate a Endemias em Rio Branco, Acre, Brasil. A definição dos temas geradores é resultado do diálogo entre pesquisadores de diferentes áreas, trabalhadores que atuam ou atuaram no combate às endemias, bem como de discentes e docentes do Curso Técnico em Segurança do Trabalho no Instituto Federal do Acre (IFAC, mediante exercício de atividades de ensino, pesquisa e extensão. As pesquisas histórica e documental permitiram que se estabelecessem os nexos entre os projetos de desenvolvimento que impactaram significativamente o ambiente e as relações de trabalho na saúde daí resultantes.

The determination of engineering parameters for the sanitary landfill, Savannah River Site

International Nuclear Information System (INIS)

McMullin, S.R.; Smalley, R.C.; Flood, P.J.

1993-01-01

The Savannah River Site is a 315 square mile, Department of Energy production facility located in western South Carolina. This facility has multiple operational areas which generate a variety of waste materials. Over the nearly 40 years of operation, sanitary wastes were deposited in a 60-acre, permitted solid waste disposal facility located on the site. Refuse and other clean wastes were deposited in shallow, slit trenches, ranging in size from 20 to 50 feet-wide and approximately 400 feet long. The historical depth of deposition appears to range between 12 and 15 feet below the ground surface. Recent changes in regulations has classified some wastes contained within the landfill as hazardous wastes, necessitating the closure of this facility as a RCRA hazardous waste management facility. The focus of this paper is to present the innovative techniques used to fully determine the engineering parameters necessary to reasonably predict future settlements, for input into the closure system design

SU-E-I-81: Assessment of CT Radiation Dose and Image Quality for An Automated Tube Potential Selection Algorithm Using Adult Anthropomorphic and ACR Phantoms

International Nuclear Information System (INIS)

Mahmood, U; Erdi, Y; Wang, W

2014-01-01

Purpose: To assess the impact of General Electrics (GE) automated tube potential algorithm, kV assist (kVa) on radiation dose and image quality, with an emphasis on optimizing protocols based on noise texture. Methods: Radiation dose was assessed by inserting optically stimulated luminescence dosimeters (OSLs) throughout the body of an adult anthropomorphic phantom (CIRS). The baseline protocol was: 120 kVp, Auto mA (180 to 380 mA), noise index (NI) = 14, adaptive iterative statistical reconstruction (ASiR) of 20%, 0.8s rotation time. Image quality was evaluated by calculating the contrast to noise ratio (CNR) and noise power spectrum (NPS) from the ACR CT accreditation phantom. CNRs were calculated according to the steps described in ACR CT phantom testing document. NPS was determined by taking the 3D FFT of the uniformity section of the ACR phantom. NPS and CNR were evaluated with and without kVa and for all available adaptive iterative statistical reconstruction (ASiR) settings, ranging from 0 to 100%. Each NPS was also evaluated for its peak frequency difference (PFD) with respect to the baseline protocol. Results: The CNR for the adult male was found to decrease from CNR = 0.912 ± 0.045 for the baseline protocol without kVa to a CNR = 0.756 ± 0.049 with kVa activated. When compared against the baseline protocol, the PFD at ASiR of 40% yielded a decrease in noise magnitude as realized by the increase in CNR = 0.903 ± 0.023. The difference in the central liver dose with and without kVa was found to be 0.07%. Conclusion: Dose reduction was insignificant in the adult phantom. As determined by NPS analysis, ASiR of 40% produced images with similar noise texture to the baseline protocol. However, the CNR at ASiR of 40% with kVa fails to meet the current ACR CNR passing requirement of 1.0

SU-E-I-81: Assessment of CT Radiation Dose and Image Quality for An Automated Tube Potential Selection Algorithm Using Adult Anthropomorphic and ACR Phantoms

Energy Technology Data Exchange (ETDEWEB)

Mahmood, U; Erdi, Y; Wang, W [Memorial Sloan Kettering Cancer Center, NY, NY (United States)

2014-06-01

Purpose: To assess the impact of General Electrics (GE) automated tube potential algorithm, kV assist (kVa) on radiation dose and image quality, with an emphasis on optimizing protocols based on noise texture. Methods: Radiation dose was assessed by inserting optically stimulated luminescence dosimeters (OSLs) throughout the body of an adult anthropomorphic phantom (CIRS). The baseline protocol was: 120 kVp, Auto mA (180 to 380 mA), noise index (NI) = 14, adaptive iterative statistical reconstruction (ASiR) of 20%, 0.8s rotation time. Image quality was evaluated by calculating the contrast to noise ratio (CNR) and noise power spectrum (NPS) from the ACR CT accreditation phantom. CNRs were calculated according to the steps described in ACR CT phantom testing document. NPS was determined by taking the 3D FFT of the uniformity section of the ACR phantom. NPS and CNR were evaluated with and without kVa and for all available adaptive iterative statistical reconstruction (ASiR) settings, ranging from 0 to 100%. Each NPS was also evaluated for its peak frequency difference (PFD) with respect to the baseline protocol. Results: The CNR for the adult male was found to decrease from CNR = 0.912 ± 0.045 for the baseline protocol without kVa to a CNR = 0.756 ± 0.049 with kVa activated. When compared against the baseline protocol, the PFD at ASiR of 40% yielded a decrease in noise magnitude as realized by the increase in CNR = 0.903 ± 0.023. The difference in the central liver dose with and without kVa was found to be 0.07%. Conclusion: Dose reduction was insignificant in the adult phantom. As determined by NPS analysis, ASiR of 40% produced images with similar noise texture to the baseline protocol. However, the CNR at ASiR of 40% with kVa fails to meet the current ACR CNR passing requirement of 1.0.

Utilización del acrílico dental (metil metacrilato) como barra estabilizadora-conectora para reducciones cerradas en fracturas de tibia/peroné o radio/cúbito en caninos

OpenAIRE

Cavero A., Francisco; Fernández A., Víctor

2005-01-01

El metil metacrilato (mmc) es una resina acrílica utilizada en moldes para fabricar prótesis dentales y puede cumplir la función de barra estabilizadora-conectora en la reducción de fracturas, permitiendo la colocación de clavos en planos múltiples. El presente trabajo tuvo como objetivo comprobar que el acrílico dental sirve como barra conectora en la fijación externa esquelética, y demostrar que es posible fijar las fracturas con un método poco traumático, alejado del foco fracturario, para...

The prognostic value of the clinical ACR classification criteria of knee osteoarthritis for persisting knee complaints and increase of disability in general practice

NARCIS (Netherlands)

Belo, J. N.; Berger, M. Y.; Koes, B. W.; Bierma-Zeinstra, S. M. A.

2009-01-01

Objective: To assess the prognostic value of the clinical American College of Rheumatism (ACR) classification criteria of knee osteoarthritis (OA) on persisting knee complaints and increase of disability in adult patients with knee pain in general practice after 1-year follow-up. Methods: Patients

ACR Appropriateness Criteria Assessment of Fetal Well-Being.

Science.gov (United States)

Simpson, Lynn; Khati, Nadia J; Deshmukh, Sandeep P; Dudiak, Kika M; Harisinghani, Mukesh G; Henrichsen, Tara L; Meyer, Benjamin J; Nyberg, David A; Poder, Liina; Shipp, Thomas D; Zelop, Carolyn M; Glanc, Phyllis

2016-12-01

Although there is limited evidence that antepartum testing decreases the risk for fetal death in low-risk pregnancies, women with high-risk factors for stillbirth should undergo antenatal fetal surveillance. The strongest evidence supporting antepartum testing pertains to pregnancies complicated by intrauterine fetal growth restriction secondary to uteroplacental insufficiency. The main ultrasound-based modalities to determine fetal health are the biophysical profile, modified biophysical profile, and duplex Doppler velocimetry. In patients at risk for cardiovascular compromise, fetal echocardiography may also be indicated to ensure fetal well-being. Although no single antenatal test has been shown to be superior, all have high negative predictive values. Weekly or twice-weekly fetal testing has become the standard practice in high-risk pregnancies. The timing for the initiation of assessments of fetal well-being should be tailored on the basis of the risk for stillbirth and the likelihood of survival with intervention. The ACR Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer-reviewed journals and the application of well-established methodologies (the RAND/UCLA Appropriateness Method and the Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances in which evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment. Copyright © 2016 American College of Radiology. Published by Elsevier Inc. All rights reserved.

General Design Memorandum Appendix D, Environmental Documents. Pascagoula Harbor Channel Improvement, Pascagoula, Mississippi

Science.gov (United States)

1992-02-01

herbaceous uplands ( Cogon grass ), and 29 acres of tidal marsh. The entire area includes about 183 acres. 3. Alternative 3 is similar to Alternative 2...acres of tidal wetlands outside of the old Tenneco dike 61 acres of scrub/shrub uplands 21 acres of herbaceous uplands ( Cogon grass ) While wetlands...shrub wetlands exist within the old levees at the Tenneco site. Wetland grasses include such species as threesquare (Sciryus spp.), black needlerush

Remedial design of the Fultz Landfill Site, Byesville, Ohio

International Nuclear Information System (INIS)

Rajaram, V.; Riesing, R.; Bloom, T.

1994-01-01

The Fultz Landfill Superfund (Fultz) site is a 30-acre hazardous waste landfill located near Byesville, Ohio. The site is approximately 75 miles east of Columbus and 3 miles southwest of Cambridge, the largest city in Guernsey County, Ohio. The landfill is situated on the north slope of a ridge that overlies abandoned coal mines in the Upper Freeport Coal seam. The north half of the landfill lies in an unreclaimed strip mine in the Upper Freeport Coal seam, where saturated portions of surface mine spoils and natural soils form the ''shallow aquifer''. The south half of the landfill lies 40 to 50 feet (ft.) above an abandoned, flooded deep mine in the same coal seam. The flooded deep mine forms an aquifer referred to as the ''coal mine aquifer''. This paper presents the results of design studies completed by PRC Environmental Management, Inc. (PRC), during 1993, and the remedial design (RD) of the components specified by the US Environmental Protection Agency (EPA) Record of Decision (ROD) for the Fultz site (EPA 1991). The remedy specified in the ROD includes a multilayer landfill cap that is compliant with Resource Conservation and Recovery Act (RCRA) Subtitle C guidelines, a leachate collection and groundwater extraction and treatment system, and stabilizing mine voids underlying the southern portion of the site. Vinyl chloride is the only contaminant exceeding a maximum contaminant limit (MCL) in the coal mine aquifer

Environmental assessment of remedial action at the Naturita uranium processing site near Naturita, Colorado: Revision 5

Energy Technology Data Exchange (ETDEWEB)

1994-10-01

Title 1 of the Uranium Mill Tailings Radiation Control Act (UMTRCA) of 1978, Public Law (PL) 95-604, authorized the US Department of Energy (DOE) to perform remedial action at the inactive Naturita, Colorado, uranium processing site to reduce the potential health effects from the radioactive materials at the site and at vicinity properties associated with the site. Title 2 of the UMTRCA authorized the US Nuclear Regulatory Commission (NRC) or agreement state to regulate the operation and eventual reclamation of active uranium processing sites. The uranium mill tailings at the site were removed and reprocessed from 1977 to 1979. The contaminated areas include the former tailings area, the mill yard, the former ore storage area, and adjacent areas that were contaminated by uranium processing activities and wind and water erosion. The Naturita remedial action would result in the loss of 133 acres (ac) of contaminated soils at the processing site. If supplemental standards are approved by the NRC and the state of Colorado, approximately 112 ac of steeply sloped contaminated soils adjacent to the processing site would not be cleaned up. Cleanup of this contamination would have adverse environmental consequences and would be potentially hazardous to remedial action workers.

Environmental assessment of remedial action at the Naturita uranium processing site near Naturita, Colorado: Revision 5

International Nuclear Information System (INIS)

1994-10-01

Title 1 of the Uranium Mill Tailings Radiation Control Act (UMTRCA) of 1978, Public Law (PL) 95-604, authorized the US Department of Energy (DOE) to perform remedial action at the inactive Naturita, Colorado, uranium processing site to reduce the potential health effects from the radioactive materials at the site and at vicinity properties associated with the site. Title 2 of the UMTRCA authorized the US Nuclear Regulatory Commission (NRC) or agreement state to regulate the operation and eventual reclamation of active uranium processing sites. The uranium mill tailings at the site were removed and reprocessed from 1977 to 1979. The contaminated areas include the former tailings area, the mill yard, the former ore storage area, and adjacent areas that were contaminated by uranium processing activities and wind and water erosion. The Naturita remedial action would result in the loss of 133 acres (ac) of contaminated soils at the processing site. If supplemental standards are approved by the NRC and the state of Colorado, approximately 112 ac of steeply sloped contaminated soils adjacent to the processing site would not be cleaned up. Cleanup of this contamination would have adverse environmental consequences and would be potentially hazardous to remedial action workers

The ACR-program for automatic finite element model generation for part through cracks

International Nuclear Information System (INIS)

Leinonen, M.S.; Mikkola, T.P.J.

1989-01-01

The ACR-program (Automatic Finite Element Model Generation for Part Through Cracks) has been developed at the Technical Research Centre of Finland (VTT) for automatic finite element model generation for surface flaws using three dimensional solid elements. Circumferential or axial cracks can be generated on the inner or outer surface of a cylindrical or toroidal geometry. Several crack forms are available including the standard semi-elliptical surface crack. The program can be used in the development of automated systems for fracture mechanical analyses of structures. The tests for the accuracy of the FE-mesh have been started with two-dimensional models. The results indicate that the accuracy of the standard mesh is sufficient for practical analyses. Refinement of the standard mesh is needed in analyses with high load levels well over the limit load of the structure

Mg co-ordination with potential carcinogenic molecule acrylamide: Spectroscopic, computational and cytotoxicity studies

Science.gov (United States)

Singh, Ranjana; Mishra, Vijay K.; Singh, Hemant K.; Sharma, Gunjan; Koch, Biplob; Singh, Bachcha; Singh, Ranjan K.

2018-03-01

Acrylamide (acr) is a potential toxic molecule produced in thermally processed food stuff. Acr-Mg complex has been synthesized chemically and characterized by spectroscopic techniques. The binding sites of acr with Mg were identified by experimental and computational methods. Both experimental and theoretical results suggest that Mg coordinated with the oxygen atom of Cdbnd O group of acr. In-vitro cytotoxicity studies revealed significant decrease in the toxic level of acr-Mg complex as compared to pure acr. The decrease in toxicity on complexation with Mg may be a useful step for future research to reduce the toxicity of acr.

ACR Appropriateness Criteria on Induction and Adjuvant Therapy for Stage N2 Non-Small-Cell Lung Cancer: Expert Panel on Radiation Oncology-Lung

International Nuclear Information System (INIS)

Gopal, Ramesh S.; Dubey, Sarita; Rosenzweig, Kenneth E.; Chang, Joe Yujiao; Decker, Roy; Gewanter, Richard M.; Kong Fengming; Lally, Brian E.; Langer, Corey J.; Lee, Hoon Ku; Movsas, Benjamin M.D.

2010-01-01

'The American College of Radiology seeks and encourages collaboration with other organizations on the development of the ACR Appropriateness Criteria through society representation on expert panels. Participation by representatives from collaborating societies on the expert panel does not necessarily imply society endorsement of the final document.'

Accessibility and content of individualized adult reconstructive hip and knee/musculoskeletal oncology fellowship web sites.

Science.gov (United States)

Young, Bradley L; Cantrell, Colin K; Patt, Joshua C; Ponce, Brent A

2018-06-01

Accessible, adequate online information is important to fellowship applicants. Program web sites can affect which programs applicants apply to, subsequently altering interview costs incurred by both parties and ultimately impacting rank lists. Web site analyses have been performed for all orthopaedic subspecialties other than those involved in the combined adult reconstruction and musculoskeletal (MSK) oncology fellowship match. A complete list of active programs was obtained from the official adult reconstruction and MSK oncology society web sites. Web site accessibility was assessed using a structured Google search. Accessible web sites were evaluated based on 21 previously reported content criteria. Seventy-four adult reconstruction programs and 11 MSK oncology programs were listed on the official society web sites. Web sites were identified and accessible for 58 (78%) adult reconstruction and 9 (82%) MSK oncology fellowship programs. No web site contained all content criteria and more than half of both adult reconstruction and MSK oncology web sites failed to include 12 of the 21 criteria. Several programs participating in the combined Adult Reconstructive Hip and Knee/Musculoskeletal Oncology Fellowship Match did not have accessible web sites. Of the web sites that were accessible, none contained comprehensive information and the majority lacked information that has been previously identified as being important to perspective applicants.

Body adiposity and nutritional status among indigenous children in villages of Kaxinawá tribe in Southwest Amazon rain forest, State of Acre, Brazil

Directory of Open Access Journals (Sweden)

Orivaldo Florêncio de Souza

2005-12-01

Full Text Available The present study aimed to investigate body adiposity and nutritional status among indigenous children from Kaxinawá Tribe by using anthropometry. The sample was composed by 93 children aged 6 to 10 years and of both sexes, living at the villages Kaxinawá do Caucho e Paroá, in the state of Acre, Brazil. Body adiposity was estimated by skinfold thickness at triceps and subscapular sites and by the sum of these two skinfolds. Nutritional status was identified by the indicators weight-for age (w/a, stature-for-age (s/a and weight-for-stature (w/s using z-score cut-off points suggested by the World Health Organization. For comparison between sexes, the Student’s t-test was used. Low body fat prevalence was observed in 83.7% of boys and 62% of girls. There were significant differences between sexes at 8 and 10 years of age for the triceps skinfolds and the sum of skinfolds. For the subscapular skinfold, the difference was observed only at 8 years of age. Chronic malnutrition was detected in both sexes and the prevalence depended upon the applied criteria. The prevalence was 76.3% for s/a and 47.3% for w/a. Acute malnutrition was present among 12.9% of children when using w/s. Boys tended to have higher prevalence for chronic malnutrition (s/a and w/a, while the girls for acute malnutrition (w/s. It was concluded that there is a high prevalence of malnutrition and low body adiposity among indigenous Kaxinawá children in the state of Acre, Brazil. RESUMO O presente estudo foi realizado com o objetivo de investigar a adiposidade corporal e o estado nutricional de crianças indígenas da Tribo Kaxinawá, através do método antropométrico. A amostra constitui-se de 93 crianças, de ambos os sexos, na faixa etária de 06 a 10 anos de idade das aldeias indígenas Kaxinawá do Caucho e Paroá, no estado do Acre. Na adiposidade corporal, verificou-se as dobras cutâneas tricipital, subescapular e somatório de dobras cutâneas (tríceps mais

Environmental Assessment and Finding of No Significant Impact: The Nevada Test Site Development Corporations's Desert Rock Sky Park at the Nevada Test Site

Energy Technology Data Exchange (ETDEWEB)

N/A

2000-03-01

The United States Department of Energy has prepared an Environmental Assessment (DOE/EA-1300) (EA) which analyzes the potential environmental effects of developing operating and maintaining a commercial/industrial park in Area 22 of the Nevada Test Site, between Mercury Camp and U.S. Highway 95 and east of Desert Rock Airport. The EA evaluates the potential impacts of infrastructure improvements necessary to support fill build out of the 512-acre Desert Rock Sky Park. Two alternative actions were evaluated: (1) Develop, operate and maintain a commercial/industrial park in Area 22 of the Nevada Test Site, and (2) taking no action. The purpose and need for the commercial industrial park are addressed in Section 1.0 of the EA. A detailed description of the proposed action and alternatives is in section 2.0. Section 3.0 describes the affected environment. Section 4.0 the environmental consequences of the proposed action and alternative. Cumulative effects are addressed in Section 5.0. Mitigation measures are addressed in Section 6.0. The Department of Energy determined that the proposed action of developing, operating and maintaining a commercial/industrial park in Area 22 of the Nevada Test Site would best meet the needs of the agency.

New Brunswick Site annual environmental report for calendar year 1991, New Brunswick, New Jersey

International Nuclear Information System (INIS)

1992-09-01

This document describes the environmental monitoring program at the New Brunswick Site (NBS) and surrounding area, implementation of the program, and monitoring results for 1991. The site, near New Brunswick,, New Jersey, is a 5.6-acre vacant, fenced, and grass-covered area. Environmental monitoring of NBS began in 1981 when the site was part of the US Department of Energy's (DOE) Surplus Facilities Management Program. In 1990 responsibility for NBS was transferred to the Formerly Utilized Sites Remedial Action Program (FUSP.4P). FUSRAP is a DOE program to identify and decontaminate or otherwise control sites where residual radioactive materials remain from the,early years of the nation's atomic energy program or from commercial operations causing conditions that Congress has authorized DOE to remedy. The environmental monitoring program at NBS includes sampling networks for radon and thoron in air; external gamma radiation exposure; and radium-226, radium-228, thorium-228, thorium-230, thorium-232, americium-241, cesium-137, plutonium-239, and total uranium in surface water, sediment, and groundwater. Several nonradiological parameters are also measured in groundwater, surface water, and sediments. Monitoring results are compared with applicable Environmental Protection Agency standards, DOE derived concentration guides, dose limits, and other requirements in DOE orders. Environmental standards are established to protect public health and the environment

Todd Berliner. Hollywood Incoherent. Narration in Seventies Cinema.

Directory of Open Access Journals (Sweden)

Pascal Lefèvre

2010-12-01

Full Text Available

Todd Berliner. Hollywood Incoherent. Narration in Seventies Cinema.

Austin: University of Texas Press, 2010.

ISBN-10: 0292722796

ISBN-13: 978-0292722798