WorldWideScience

Sample records for sepp marika mnd

  1. Uusi võimalusi pakkuv kasulik bakter / Villu Päärt, Siim Sepp

    Index Scriptorium Estoniae

    Päärt, Villu, 1972-

    2008-01-01

    Äsja võitis Lactobacillus fermentum ME-3 avastaja Tartu Ülikooli professor Marika Mikelsaar koos kolleegidega Soulis ülemaailmsel naisleiutajate konkursil kuldmedali. Bakterite omaduste uurimine jätkub. Marika Mikelsaare juhtimisel katsetati kõhutüüfusesse nakatatud hiirte peal, millist mõju avaldab see, kui antibiootikumi ravi ajal anda hiirtele ka ME-3 sisaldavat probiootikumi

  2. Establishing the UK DNA Bank for motor neuron disease (MND).

    Science.gov (United States)

    Smith, Lucy; Cupid, B C; Dickie, B G M; Al-Chalabi, A; Morrison, K E; Shaw, C E; Shaw, P J

    2015-07-14

    In 2003 the Motor Neurone Disease (MND) Association, together with The Wellcome Trust, funded the creation of a national DNA Bank specific for MND. It was anticipated that the DNA Bank would constitute an important resource to researchers worldwide and significantly increase activity in MND genetic research. The DNA Bank houses over 3000 high quality DNA samples, all of which were donated by people living with MND, family members and non-related controls, accompanied by clinical phenotype data about the patients. Today the primary focus of the UK MND DNA Bank still remains to identify causative and disease modifying factors for this devastating disease.

  3. Nauding kehale ja meelele / Marika Aret ; tekst Inna Inanna

    Index Scriptorium Estoniae

    Aret, Marika

    2014-01-01

    Mustamäel Mustamäe tee 17 avatud Bliss majast, kus muude teenuste kõrval pakutakse buffeeerestoranis ja kohvikus taime- ja toortoitu. Intervjuu Blissi käivitustiimi ja restorani perenaise Marika Aretiga

  4. Ene Sepp esitles esikteost "Medaljon" / Heli Talinurm

    Index Scriptorium Estoniae

    Talinurm, Heli

    2009-01-01

    Ene Sepp esitles 19. veebruaril Rapla Keskraamatukogus oma raamatut, mis pälvis kolmanda koha Eesti Lastekirjanduse Teabekeskuse ja kirjastuse Tänapäev 2008. aasta noorsooromaani võistlusel. Ly Ehini mõtteid, mida Ene Sepa raamat temas tekitas

  5. Fourier transform spectroscopy of MnH and MnD

    Science.gov (United States)

    Balfour, W. J.; Launila, O.; Klynning, L.

    Two infrared band systems, centred near 846 nm and 1060 nm in both MnH and MnD have been rotationally analysed and shown to have a common lower state. The electronic transitions lie within the quintet manifold and are here designated c 5Σ-a 5Σ and b 5Πi-a 5Σ for the 846 and 1060 nm systems, respectively. In the 846 nm system in MnH all 10 main branches have been found in the 0-0 and 1-1 bands, while in MnD the data are complete only for 0-0. Satellite branches have been identified in the 1060 nm system and all spin and Λ-type doublings have been established. The number of assigned 0-0 branches in the 1060 nm system is 35 for MnH and 37 for MnD. Molecular constants have been determined for all three states involved. Λ-doubling diagrams are presented for b 5Πi state with v = 1, 2 levels in MnH and with the v = 2 level in MnD. Local perturbations in c5Σ (v = 1) in MnH are suspected to originate from the v = 3 level of b 5Πi.

  6. Management of respiration in MND/ALS patients: an evidence based review.

    Science.gov (United States)

    Heffernan, Catherine; Jenkinson, Crispin; Holmes, Tricia; Macleod, Heidi; Kinnear, William; Oliver, David; Leigh, Nigel; Ampong, Mary-Ann

    2006-03-01

    This systematic review comprises an objective appraisal of the evidence in regard to the management of respiration in patients with motor neuron disease (MND/ALS). Studies were identified through computerised searches of 32 databases. Internet searches of websites of drug companies and MND/ALS research web sites, 'snow balling' and hand searches were also employed to locate any unpublished study or other 'grey literature' on respiration and MND/ALS. Since management of MND/ALS involves a number of health professionals and care workers, searches were made across multiple disciplines. No time frame was imposed on the search in order to increase the probability of identifying all relevant studies, although there was a final limit of March 2005. Recommendations for patient and carer-based guidelines for the clinical management of respiration for MND/ALS patients are suggested on the basis of qualitative analyses of the available evidence. However, these recommendations are based on current evidence of best practice, which largely comprises observational research and clinical opinion. There is a clear need for further evidence, in particular randomised and non-randomised controlled trials on the effects of non-invasive ventilation and additional larger scale cohort studies on the issues of initial assessment of respiratory symptoms, and management and timing of interventions.

  7. Lossi tn 16, Kuressaare / Tõnu Sepp

    Index Scriptorium Estoniae

    Sepp, Tõnu

    2006-01-01

    1893. a. valminud kahe torniga puithoone ajaloost ja restaureerimisest (juuni 2004 - märts 2005) eravillaks. Projekteerija: Kuressaare Kommunaalprojekt OÜ. Ehituse peatöövõtja: Deena Ehitus OÜ, tööde tegelik tegija: Primus PR OÜ. Muinsuskaitseline järelevalve: Tõnu Sepp. 3 värv. välis- ja 2 sisevaadet

  8. checkCIF/PLATON report Datablock: mnd

    Indian Academy of Sciences (India)

    THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC REFEREE. No syntax errors found. CIF dictionary Interpreting this report. Datablock: mnd. Bond precision:.

  9. Tuotteiden ohjeistaminen osana hankintatoimintaa ja tuotetiedonhallintaa : case: Seppälä Oy

    OpenAIRE

    Heikkonen, Veera

    2010-01-01

    Tuoteohjeistusten tekeminen on arkipäivää suomalaisissa vaatetusalan yrityksissä. Tuotteiden hankinta ulkomailta on yleistynyt huomattavasti, joka taas on tehnyt tuoteohjeistuksista tärkeitä työkaluja yrityksen toiminnassa. Tuoteohjeistusten avulla suunnittelijan ideat ja ajatukset toteutetaan oikeaksi tuotteeksi. Tämän opinnäytetyön tarkoitus oli kehittää Seppälä Oy:lle yhtenäinen tuoteohjeis-tuspohja, joka on selkeä ja toimiva. Projektin lähtökohtainen tarkoitus on, että Seppälä voi hy...

  10. Guidelines for preclinical animal research in ALS/MND: A consensus meeting.

    Science.gov (United States)

    Ludolph, Albert C; Bendotti, Caterina; Blaugrund, Eran; Chio, Adriano; Greensmith, Linda; Loeffler, Jean-Philippe; Mead, Richard; Niessen, Heiko G; Petri, Susanne; Pradat, Pierre-Francois; Robberecht, Wim; Ruegg, Markus; Schwalenstöcker, Birgit; Stiller, Detlev; van den Berg, Leonard; Vieira, Fernando; von Horsten, Stephan

    2010-01-01

    The development of therapeutics for ALS/MND is largely based on work in experimental animals carrying human SOD mutations. However, translation of apparent therapeutic successes from in vivo to the human disease has proven difficult and a considerable amount of financial resources has been apparently wasted. Standard operating procedures (SOPs) for preclinical animal research in ALS/MND are urgently required. Such SOPs will help to establish SOPs for translational research for other neurological diseases within the next few years. To identify the challenges and to improve the research methodology, the European ALS/MND group held a meeting in 2006 and published guidelines in 2007 (1). A second international conference to improve the guidelines was held in 2009. These second and improved guidelines are dedicated to the memory of Sean F. Scott.

  11. Büroo Ignite = Ignite office / Priit Põldme, Reet Sepp

    Index Scriptorium Estoniae

    Põldme, Priit, 1971-

    2013-01-01

    Büroo Ignite (Tatari 25, Tallinn) sisekujundusest. Sisearhitektid Priit Põldme ja Reet Sepp (SAB Joonprojekt). Arhitektid Heiki Taras ja Ahti Luhaäär (Arhitektibüroo Pilter ja Taras). Sisearhitekti ja ESLi aastapreemiate žürii esimehe Kaido Kivi arvamus

  12. Ott Sepp ohverdab rolli nimel juuksed? / Liina Metsküla

    Index Scriptorium Estoniae

    Metsküla, Liina

    2007-01-01

    Madis Kõivu näidend "Catrozza ehk Illusionist" Võru Teatriateljee suvelavastusena. Lavastaja Taago Tubin. Külalisnäitlejad on Ott Sepp ja Leino Rei. Lisaks tutvustus "Müstiline mees ja illusionist ehk Castozza lugu"

  13. Transition probabilities and dissociation energies of MnH and MnD molecules

    International Nuclear Information System (INIS)

    Nagarajan, K.; Rajamanickam, N.

    1997-01-01

    The Frank-Condon factors (vibrational transition probabilities) and r-centroids have been evaluated by the more reliable numerical integration procedure for the bands of A-X system of MnH and MnD molecules, using a suitable potential. By fitting the Hulburt- Hirschfelder function to the experimental potential curve using correlation coefficient, the dissociation energy for the electronic ground states of MnH and MnD molecules, respectively have been estimated as D 0 0 =251±5 KJ.mol -1 and D 0 0 =312±6 KJ.mol -1 . (authors)

  14. From symptom onset to a diagnosis of amyotrophic lateral sclerosis/motor neuron disease (ALS/MND): experiences of people with ALS/MND and family carers - a qualitative study.

    Science.gov (United States)

    O'Brien, Mary R; Whitehead, Bridget; Jack, Barbara A; Mitchell, John Douglas

    2011-03-01

    Our objectives were to explore the personal perspectives of the diagnostic experience for people with ALS/MND and their family carers identifying issues that could impact positively or negatively on these experiences. We conducted a qualitative study with face-to-face interviews to capture experiences from 24 people with ALS/MND and 18 current family carers. Ten former family carers were also interviewed. The diagnostic experience was fraught with difficulties. There was failure to recognize the significance of some symptoms by patients, carers and primary and secondary care health professionals, which ultimately delayed diagnosis. Delivery of the diagnosis was frequently unsatisfactory despite international guidelines on the subject. Immediate post-diagnosis support often compared negatively to that provided for people with cancer. In conclusion, this study has identified a need for a more streamlined and empathetic diagnostic pathway for people with ALS/MND. Improvements to medical curricula are required to increase awareness of the condition and reduce the likelihood of diagnostic delays resulting from a failure to recognize the need for a neurological referral. Greater public awareness of the illness is also needed. Furthermore, delivery of the diagnosis should more closely adhere to established guidelines.

  15. [Production effect comparison of SEPP and GPx between HepG2 and Hela cells with different selenocompounds].

    Science.gov (United States)

    Wang, Qin; Gao, Lina; Han, Feng; Lu, Jiaxi; Liu, Yiqun; Sun, Licui; Huang, Zhenwu

    2016-03-01

    To compare the effect of several selenocompounds on the productions of SEPP and GPx in HepG2 and Hela cells. The cultured HepG2 and Hela cells were divided into the control, Na2SeO3, SeMet and MeSeCys groups. After adding the selected selenocompounds (with the respective concentration 0.01 and 0.1 μmol/L), the experimental groups were then incubated for 48 h and 72 h. Finally, the cell culture supernatants and homogenates were collected for the SEPP and GPx concentrations detection by a double-antibody sandwich enyme-linked immuno-sorbent-assay (ELISA). The SEPP and GPx concentrations in Hela cells treated with 0.1 μmol/L SeMet and MeSeCys were significantly higher than that in the control group (P cell treated with 0.1 μmol/L selenocompounds were significantly higher than that in Hela cells (P cells are more beneficial to the production of selenoproteins than Hela cells.

  16. Assessing social isolation in motor neurone disease: a Rasch analysis of the MND Social Withdrawal Scale.

    Science.gov (United States)

    Gibbons, Chris J; Thornton, Everard W; Ealing, John; Shaw, Pamela J; Talbot, Kevin; Tennant, Alan; Young, Carolyn A

    2013-11-15

    Social withdrawal is described as the condition in which an individual experiences a desire to make social contact, but is unable to satisfy that desire. It is an important issue for patients with motor neurone disease who are likely to experience severe physical impairment. This study aims to reassess the psychometric and scaling properties of the MND Social Withdrawal Scale (MND-SWS) domains and examine the feasibility of a summary scale, by applying scale data to the Rasch model. The MND Social Withdrawal Scale was administered to 298 patients with a diagnosis of MND, alongside the Hospital Anxiety and Depression Scale. The factor structure of the MND Social Withdrawal Scale was assessed using confirmatory factor analysis. Model fit, category threshold analysis, differential item functioning (DIF), dimensionality and local dependency were evaluated. Factor analysis confirmed the suitability of the four-factor solution suggested by the original authors. Mokken scale analysis suggested the removal of item five. Rasch analysis removed a further three items; from the Community (one item) and Emotional (two items) withdrawal subscales. Following item reduction, each scale exhibited excellent fit to the Rasch model. A 14-item Summary scale was shown to fit the Rasch model after subtesting the items into three subtests corresponding to the Community, Family and Emotional subscales, indicating that items from these three subscales could be summed together to create a total measure for social withdrawal. Removal of four items from the Social Withdrawal Scale led to a four factor solution with a 14-item hierarchical Summary scale that were all unidimensional, free for DIF and well fitted to the Rasch model. The scale is reliable and allows clinicians and researchers to measure social withdrawal in MND along a unidimensional construct. © 2013. Published by Elsevier B.V. All rights reserved.

  17. Fourier transform infrared emission spectra of MnH and MnD

    Science.gov (United States)

    Gordon, Iouli E.; Appadoo, Dominique R. T.; Shayesteh, Alireza; Walker, Kaley A.; Bernath, Peter F.

    2005-01-01

    Fourier transform infrared emission spectra of MnH and MnD were observed in the ground X7Σ + electronic state. The vibration-rotation bands from v = 1 → 0 to v = 3 → 2 for MnH and from v = 1 → 0 to v = 4 → 3 for MnD were recorded at an instrumental resolution of 0.0085 cm -1. Spectroscopic constants were determined for each vibrational level and equilibrium constants were found from a Dunham-type fit. The equilibrium vibrational constant ( ωe) for MnH was found to be 1546.84518(65) cm -1, the equilibrium rotational constant ( Be) is 5.6856789(103) cm -1 and the eqilibrium bond distance ( re) was determined to be 1.7308601(47) Å.

  18. Subjective perception of cocaine reward in mice assessed by a single exposure place preference (sePP) paradigm

    DEFF Research Database (Denmark)

    Runegaard, Annika H.; Jensen, Kathrine Louise; Dencker, Ditte

    2017-01-01

    -related behavior. Comparison with existing methods In rodents, the rewarding effects of drugs have often been assessed in self-administration or place preference paradigms; both involving repeated drug exposure and weeks of training and testing. New method Our investigation describes a valid approach to assess....... The sePP protocol allows further dissection of the mechanism and influence of initial cocaine exposure on subsequent drug-related behaviors by including extinction and reinstatement. The lack of sePP in female mice may reflect a biologically relevant sex difference in the initial subjective perception...

  19. Rain Sepp - kontorita juht ülemaailmses äris / Riina Kallas

    Index Scriptorium Estoniae

    Kallas, Riina

    2005-01-01

    Mobiiltelefonilogosid ning -helinaid müüva Jipii! portaali rahvusvahelise võrgu juht Rain Sepp ettevõtte arengust ja teenustest, tööst rahvusvahelise võrgu juhina, töö spetsiifilisusest, Eesti meeskonnast ning Läti, Leedu, Soome ja Londoni tiimis valitseva tööõhkkonna erinevustest. Vt. samas: 10% muusikarahast tuleb helinast; iTouch plc; www.jippii.ee

  20. Aasta Põllumees 2007 on Ermo Sepp / Silja Lättemäe

    Index Scriptorium Estoniae

    Lättemäe, Silja, 1952-

    2007-01-01

    Tallinnas Olümpia konverentsikeskuses toimunud Aasta Põllumehe konverentsil õnnitles konkursi võitjat ja nominente president Toomas Hendrik Ilves. Aasta Põllumees 2007 on seakasvataja Ermo Sepp Lääne-Virumaalt Tapa vallast Patika külast; Vt. samas lk. 11 lühiintervjuud Lauri Vaiksaarega, kes esindab konkursi Aasta Põllumees 2007 toetajat Hansa Liisingut

  1. Uniaxial low cycle fatigue behavior for pre-corroded 16MND5 bainitic steel in simulated pressurized water reactor environment

    Science.gov (United States)

    Chen, Xu; Ren, Bin; Yu, Dunji; Xu, Bin; Zhang, Zhe; Chen, Gang

    2018-06-01

    The effects of uniaxial tension properties and low cycle fatigue behavior of 16MND5 bainitic steel cylinder pre-corroded in simulated pressurized water reactor (PWR) were investigated by fatigue at room temperature in air and immersion test system, scanning electron microscopy (SEM), energy disperse spectroscopy (EDS). The experimental results indicated that the corrosion fatigue lives of 16MND5 specimen were significantly affected by the strain amplitude and simulated PWR environments. The compositions of corrosion products were complexly formed in simulated PWR environments. The porous corrosion surface of pre-corroded materials tended to generate pits as a result of promoting contact area to the fresh metal, which promoted crack initiation. For original materials, the fatigue cracks initiated at inclusions imbedded in the micro-cracks. Moreover, the simulated PWR environments degraded the mechanical properties and low cycle fatigue behavior of 16MND5 specimens remarkably. Pre-corrosion of 16MND5 specimen mainly affected the plastic term of the Coffin-Manson equation.

  2. 'All in the same boat'? Patient and carer attitudes to peer support and social comparison in Motor Neurone Disease (MND).

    Science.gov (United States)

    Locock, Louise; Brown, Janice B

    2010-10-01

    This paper explores attitudes to peer support among people with Motor Neurone Disease (MND) and their family carers. It reports findings from a secondary analysis of data from two UK interview studies conducted by the authors. The process of secondary analysis is reported in detail. 48 people with MND and 22 carers were interviewed in 2005-2007. The authors identified narrative extracts on peer support from their own datasets and exchanged them for independent thematic analysis. Subsequent discussion, drawing on literature on support groups and social comparison, led to an exploration of two overarching themes: valuing camaraderie and comparison, and choosing isolation. Findings suggest that social comparison theory is a useful framework for analysing attitudes to MND support groups, but that on its own it is insufficient. 'Valuing camaraderie and comparison' explains how support groups offer practical and social support, as well as beneficial opportunities for social comparison. Seeing others coping well with the condition can provide hope, while downward comparison with those worse off can also make people feel better about their own situation. However, most people are also shocked and saddened by seeing others with the condition. Tension of identity can occur when group membership starts to define the individual as 'a person with MND, rather than the person I am that happens to have MND'. Choosing isolation can be a deliberate defensive strategy, to protect oneself from witnessing one's possible future. Levels of involvement may change over time as people struggle with their changing needs and fears. Copyright © 2010 Elsevier Ltd. All rights reserved.

  3. The Submillimeter Spectrum of MnH and MnD (X7Σ+)

    Science.gov (United States)

    Halfen, D. T.; Ziurys, L. M.

    2008-01-01

    The submillimeter-wave spectrum of the MnH and MnD radicals in their 7Σ+ ground states has been measured in the laboratory using direct absorption techniques. These species were created in the gas phase by the reaction of manganese vapor, produced in a Broida-type oven, with either H2 or D2 gas in the presence of a DC discharge. The N = 0 → 1 transition of MnH near 339 GHz was recorded, which consisted of multiple hyperfine components arising from both the manganese and hydrogen nuclear spins. The N = 2 → 3 transition of MnD near 517 GHz was measured as well, but in this case only the manganese hyperfine interactions were resolved. Both data sets were analyzed with a Hund's case b Hamiltonian, and rotational, fine structure, magnetic hyperfine, and electric quadrupole constants have been determined for the two manganese species. An examination of the magnetic hyperfine constants shows that MnH is primarily an ionic species, but has more covalent character than MnF. MnH is a good candidate species for astronomical searches with Herschel, particularly toward material associated with luminous blue variable stars.

  4. Characterizations of microstructural evolutions to heating of two 16MND5 alloys

    International Nuclear Information System (INIS)

    Vereecke, B.

    2003-01-01

    The aim of this work is to predict the risks of ruin of power plants from scenario of accidents. For that, we have to know and simulate the behaviour of material at high temperatures (600-1300 C) or more exactly, of materials of analogous composition but of different sources, constituting the vessel of a PWR reactor in 16MND5 steel. Previous studies (Vereecke and al CFM2003) have shown that the vessel steels can present in the temperature range 900-1000 C an important variability of creep behaviour and in particular of damages mechanisms (ductile or intergranular) which can radically change from a steel to another. In order to explain and model the sources of different damages, we have carried out a metallurgical study on two steels of 16MND5 type. For different kinetics of heating, have been studied: the hardnesses, the grain sizes and the thermo-electric power (TEP). This last qualitative physical measurement allows to follow in our case the dissolution of the alloy elements having precipitated, phenomenon which could be at the origin of the differences of the damage mechanisms noticed at high temperature. (O.M.)

  5. Rasked vestlused. Kuidas ma talle seda ütlen / Irene Metsis, Sami Seppänen, Peep Sooman ; intervjueerinud Heli Lehtsaar

    Index Scriptorium Estoniae

    Metsis, Irene

    2009-01-01

    Skanska EMV administratsioonijuhi Irene Metsise, AS-i Elisa Eesti tegevdirektori Sami Seppäneni ja Pindi Kinnisvara juhatuse liikme Peep Soomani soovitused negatiivse sõnumi edastamiseks töötajale. Vt. samas: 4 nõuannet juhile, kuidas end keeruliseks vestluseks ette valmistada

  6. Brittle and ductile rupture of 16MND5 steel. Irradiation effect

    International Nuclear Information System (INIS)

    Al Mundheri, M.; Soulat, P.; Pineau, A.

    1986-06-01

    Toughness tests have been made on 16MND5 steel (A508Cl3 steel) - before and after irradiation at 290 0 C (3.10 19 n/cm 2 , E > 1 MeV). It is shown that toughness is lowered following the irradiation and that it is a decreasing function of the thickness of the test pieces. In parallel, tests on three geometries of entailed specimens, prepared in the non-irradiated material, have been made at different temperatures to apply the methodology of local approach of ductile-brittle rupture [fr

  7. Uhked naised / Kozik, Eerika; Tomingas, Triin; Sepp, Karin; Liik, Kadi; Kliimask, Katrin; Saunpere, Anne ; tekst Kärt Kross

    Index Scriptorium Estoniae

    2007-01-01

    Mille üle oled enda juures tõeliselt uhke, mida võid enda kiituseks öelda? Küsimusele vastavad Starland Salongi omanik ja Loyd Tootmine OÜ osanik Eerika Kozik, psühholoog Triin Tomingas, Kontuur Leo Burnett projektidirektor Karin Sepp, Tallinna Ülikooli õppejõud Kadi Liik, AS Koolibri turundusjuht Katrin Kliimask ja eraettevõtja Anne Saunpere

  8. Microstructural influence on the local behaviour of 16MND5 steel

    International Nuclear Information System (INIS)

    Sekfali, S.

    2004-06-01

    16MND5 Steel or A508 Cl3 is used for manufacture by forging of nuclear reactor vessels. This material presents a good compromise in term of tenacity and yield stress, its microstructure is mainly bainitic tempered. Because of the chemical composition local variation and process of development, this material presents microstructural heterogeneities which can locally modify the properties of damage. In particular, some zones present a martensitic microstructure. The goal of this thesis is to bring some explanations on the influence of the microstructure; more particularly, size of the crystallographic entities and their spatial distribution on the local behaviour of 16MND5 steel. Two microstructures were elaborated for this purpose, a tempered bainitic microstructure and a tempered martensitic microstructure. An experimental characterization was carried out on the two microstructures in order to determine morphology, spatial distribution of the crystallographic orientations and tensile behaviour. A deposit of micro grid was carried out on tensile specimens to determine the experimental deformation field on a beforehand EBSD analyzed zone. The determination of the tensile behaviour allowed the identification of a multi crystalline behaviour law by a reverse method using the density of dislocation on each system of slip. This behaviour law was used in simulations with a finite element method to simulate the local mechanical field of the two microstructures and to compare with the obtained experimental deformation fields. It results, a good adequacy between simulations and experiments and the description of the influence of the neighbor grain's orientation on the local behaviour. (author)

  9. Guidelines in motor neurone disease (MND)/amyotrophic lateral sclerosis (ALS)--from diagnosis to patient care.

    Science.gov (United States)

    Mitchell, J D

    2000-12-01

    This paper reviews the scope of current guidelines in motor neurone disease (MND)/amyotrophic lateral sclerosis (ALS) and examines issues which have arisen in the preparation of these documents. The review concludes with an evaluation of the impact of the guidelines which have been produced to date and looks towards potential future developments in this area.

  10. Guidelines in motor neurone disease (MND)/amyotrophic lateral sclerosis (ALS) - from diagnosis to patient care.

    Science.gov (United States)

    Mitchell, J D

    2000-12-01

    This paper reviews the scope of current guidelines in motor neurone disease (MND)/amyotrophic lateral sclerosis (ALS) and examines issues which have arisen in the preparation of these documents. The review concludes with an evaluation of the impact of the guidelines which have been produced to date and looks towards potential future developments in this area.

  11. Diffusion-bonded 16MND5-Inconel 690-316LN junction: elaboration and process residual stresses modeling

    International Nuclear Information System (INIS)

    Martinez, Michael

    1999-01-01

    The objective of this research thesis is, on the one hand, to elaborate and to characterise a bonded junction of 16MND5 and 316LN steels, and, on the other hand, to develop a simulation tool for the prediction of microstructures after bonding, as well as residual stresses related to this process. The author first reports the study of the use of diffusion bonding by hot isostatic pressing (HIP diffusion bonding) for the bonding of 16MND5 (steel used in French PWR vessel) and 316LN (austenitic stainless steel used in piping), in order to obtain junctions adapted to a use within PWRs. In this case, the use of an Inconel insert material appeared to be necessary to avoid stainless steel carburization. Thus, inserts in Inconel 600 and 690 have been tested. The objective has then been to develop a realistic calculation of residual stresses in this assembly. These stresses are stimulated by quenching. The author notably studied the simulation of temperature dependent phase transformations, and stress induced phase transformations. An existing model is validated and applied to HIP and quenching cycles. The last part reports the calculation of residual stresses by simulation of the mechanical response of the three-component material cooled from 900 C to room temperature and thus submitted to a loading of thermal origin (dilatation) and metallurgical origin (phase transformations in the 16MND5). The effect of carbon diffusion on mechanical properties has also been taken into account. The author discusses problems faced by existing models, and explains the choice of conventional macro-mechanical models. The three materials are supposed to have a plastic-viscoplastic behaviour with isotropic and kinematic strain hardening, and this behaviour is identified between 20 and 900 C [fr

  12. Withdrawal of ventilation at the patient's request in MND: a retrospective exploration of the ethical and legal issues that have arisen for doctors in the UK.

    Science.gov (United States)

    Phelps, Kay; Regen, Emma; Oliver, David; McDermott, Chris; Faull, Christina

    2017-06-01

    Ventilatory support has benefits including prolonging survival for respiratory failure in motor neurone disease (MND). At some point some patients may wish to stop the intervention. The National Institute of Health and Care Excellence (NICE) guidance recommends research is needed on ventilation withdrawal. There is little literature focusing on the issues doctors encounter when withdrawing ventilation at the request of a patient. To identify and explore with doctors the ethical and legal issues that they had encountered in the withdrawal of ventilation at the request of a patient with MND. A retrospective thematic analysis of interviews of 24 doctors (including palliative care, respiratory, neurology and general practice) regarding their experiences with withdrawal of ventilation support from patients with MND. Respondents found withdrawal of ventilation at the request of patients with MND to pose legal, ethical and moral challenges in five themes: ethical and legal rights to withdrawal from treatment; discussions with family; discussions with colleagues; experiences of legal advice; issues contributing to ethical complexity. Though clear about the legality of withdrawal of treatment in theory, the practice led to ethical and moral uncertainty and mixed feelings. Many respondents had experienced negative reactions from other healthcare professionals when these colleagues were unclear of the distinction between palliation of symptoms, withdrawal of treatment and assisted death. Legal, ethical and practical guidance is needed for professionals who support a patient with MND who wishes to withdraw from ventilation. Open discussion of the ethical challenges is needed as well as education and support for professionals. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  13. Pävi Naskali, Marjaana Seppänen & Shahnaj Begum (eds., Ageing, Wellbeing and Climate Change in the Arctic. An interdisciplinary analysis (London: Routledge, 2015

    Directory of Open Access Journals (Sweden)

    Hermann Óskarsson

    2016-03-01

    Full Text Available Book review of: Pävi Naskali, Marjaana Seppänen and Shahnaj Begum (eds., Ageing, Wellbeing and Climate Change in the Arctic. An interdisciplinary analysis (London: Routledge’s series on advances in climate change research, 2015

  14. Stress distribution in the 16MND5 bainitic steel. Experimental analysis and polycrystalline modelling

    International Nuclear Information System (INIS)

    Pesci, R.; Inal, K.; Berveiller, M.; Masson, R.

    2003-01-01

    The 16MND5 bainitic steel being a two-phase material (ferrite/cementite), the X-Ray Diffraction (XRD) is the most efficient tool to determine the stress states into the ferritic phase (sin 2 ψ method). The latter, coupled to the observations realized during tensile tests (specimen surface and facies), have permitted to establish criteria to describe the behavior and the damaging processes of the material on a crystallographic scale, in the lower part of the ductile-to-brittle transition region and at lower temperatures [-196 deg. C;-60 deg. C]. During the loading, the damage is observed with a Scanning Electron Microscope, while the internal stresses are determined by XRD: the stress states are less important in ferrite than in bainite (macroscopic stress), the difference not exceeding 150 MPa. A multi-scale polycrystalline model is developed concurrently with the experimental measurements: a Mori-Tanaka formulation is used to describe the elastoplastic behavior of a ferritic single crystal reinforced by cementite precipitates, while the transition to the polycrystal is achieved by a self-consistent approach. The developed modeling takes into account the temperature effects on the stress states in each phase and includes a cleavage criterion (critical value of the stress normal to [100] planes), which expresses the damage of the material: thus, it enables to predict the actual experimental behavior of the 16MND5 steel in relation to temperature, and to take into account the failure process which is fragile from -120 deg. C. Besides, it is also possible to calculate the strains of the diffracting planes, which can be compared to those measured by XRD: this enables to evaluate the heterogeneity of the strains for each crystallographic orientation. (authors)

  15. Influence of metallurgical phase transformation on crack propagation of 15-5PH stainless steel and 16MND5 low carbon steel

    International Nuclear Information System (INIS)

    Liu, J.

    2012-01-01

    This study focuses on the effects of phase transformations on crack propagation. We want to understand the changes of fracture toughness during welding. In this work, fracture toughness is expressed by J-integral. There are many experimental methods to obtain the critical toughness JIC but they are impractical for our investigation during phase transformation. That is the reason why we have proposed a method coupling mechanical tests, digital image correlation and finite element simulation. The fracture tests are implemented on pre-cracked single edge notched plate sample which is easy for machining and heat conduct during phase transformation. The tests are conducted at different temperatures until rupture. Digital image correlation gives us the displacement information on every sample. Each test is then simulated by finite element where the fracture toughness is evaluated by the method G-Theta at the crack propagation starting moment found by potential drop method and digital image correlation technical. Two materials have been studied, 15Cr-5Ni martensitic precipitation hardening stainless steel and 16MND5 ferritic low carbon steel. For these two materials, different test temperatures were chosen before, during and after phase transformation for testing and failure characterization of the mechanical behavior. Investigation result shows that metallurgical phase transformation has an influence on fracture toughness and further crack propagation. For 15-5PH, the result of J1C shows that the as received 15-5PH has higher fracture toughness than the one at 200 C. The toughness is also higher than the original material after one cycle heat treatment probably due to some residual austenite. Meanwhile, pure austenite 15-5PH at 200 C has higher fracture toughness than pure martensitic 15-5PH at 200 C. For 16MND5, the result also proves that the phase transformation affects fracture toughness. The as received material has bigger J1C than the situation where it was heated

  16. The synthesis and crystal structures of the first rare-earth alkaline-earth selenite chlorides MNd10(SeO3)12Cl8 (M=Ca and Sr)

    International Nuclear Information System (INIS)

    Berdonosov, P.S.; Olenev, A.V.; Dolgikh, V.A.; Lightfoot, P.

    2007-01-01

    Two new alkaline-earth Nd selenite chlorides MNd 10 (SeO 3 ) 12 Cl 8 (M=Ca, Sr) were obtained using crystal growth from alkaline-earth chloride melts in quartz tubes. These new compounds crystallize in the orthorhombic system in space group C cca (no. 68). The compounds were studied by energy dispersive X-ray spectroscopy (EDX) and X-ray diffraction. It was shown that both compounds adopt the same structure type, constructed by complex [M 11 (SeO 3 ) 12 ] 8+ slabs separated by chloride anion layers perpendicular to the longest cell parameter. The SeO 3 groups show a pyramidal shape and may be described as SeO 3 E tetrahedra. Such SeO 3 groups decorate the Nd-O skeletons forming the [M 11 (SeO 3 ) 12 ] 8+ slabs. - Graphical abstract: Two new alkaline-earth Nd selenite chlorides MNd 10 (SeO 3 ) 12 Cl 8 (M=Ca, Sr) were synthesized. These structures are constructed by [M 11 (SeO 3 ) 12 ] 8+ slabs separated by chloride anion layers

  17. Microstructure and Ductility-Dip Cracking Susceptibility of Circumferential Multipass Dissimilar Weld Between 20MND5 and Z2CND18-12NS with Ni-Base Filler Metal 52

    Science.gov (United States)

    Qin, Renyao; Duan, Zhaoling; He, Guo

    2013-10-01

    The large circumferential multipass dissimilar weld between 20MND5 steel and Z2CND18-12NS stainless steel welded with FM52 filler material was investigated in terms of the diluted composition, the grain boundary precipitation, and the ductility-dip cracking (DDC) susceptibility of the weld. The diluted composition of the weld is composed of 37 to 47 pct Ni, 21 to 24 pct Cr, and 28 to 40 pct Fe, which are inhomogeneous along the depth and over the width of the deep weld. The carbon content has a distribution in the region of the surface weld from a high level (~0.20 pct) in the zone near 20MND5 steel to a normal level (~0.03 pct) in the zone near Z2CND18-12NS stainless steel. The carbon distribution is corresponding to the grain boundary carbides. The minimum threshold strains for DDC occur in the temperature range of 1223 K to 1323 K (950 °C to 1050 °C), which are 0.5, 0.35, and 0.4 pct for the root weld, middle region, and the surface weld, respectively. The dissimilar weld has the largest susceptibility to the DDC compared to the filler metal 52 and the Inconel 690.

  18. Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage

    Science.gov (United States)

    Barrett, Caitlyn W.; Reddy, Vishruth K.; Short, Sarah P.; Motley, Amy K.; Lintel, Mary K.; Bradley, Amber M.; Freeman, Tanner; Vallance, Jefferson; Ning, Wei; Parang, Bobak; Poindexter, Shenika V.; Fingleton, Barbara; Chen, Xi; Washington, Mary K.; Wilson, Keith T.; Shroyer, Noah F.; Hill, Kristina E.; Burk, Raymond F.; Williams, Christopher S.

    2015-01-01

    Patients with inflammatory bowel disease are at increased risk for colon cancer due to augmented oxidative stress. These patients also have compromised antioxidant defenses as the result of nutritional deficiencies. The micronutrient selenium is essential for selenoprotein production and is transported from the liver to target tissues via selenoprotein P (SEPP1). Target tissues also produce SEPP1, which is thought to possess an endogenous antioxidant function. Here, we have shown that mice with Sepp1 haploinsufficiency or mutations that disrupt either the selenium transport or the enzymatic domain of SEPP1 exhibit increased colitis-associated carcinogenesis as the result of increased genomic instability and promotion of a protumorigenic microenvironment. Reduced SEPP1 function markedly increased M2-polarized macrophages, indicating a role for SEPP1 in macrophage polarization and immune function. Furthermore, compared with partial loss, complete loss of SEPP1 substantially reduced tumor burden, in part due to increased apoptosis. Using intestinal organoid cultures, we found that, compared with those from WT animals, Sepp1-null cultures display increased stem cell characteristics that are coupled with increased ROS production, DNA damage, proliferation, decreased cell survival, and modulation of WNT signaling in response to H2O2-mediated oxidative stress. Together, these data demonstrate that SEPP1 influences inflammatory tumorigenesis by affecting genomic stability, the inflammatory microenvironment, and epithelial stem cell functions. PMID:26053663

  19. Biomonitoring of selenoprotein P in human serum by fast affinity chromatography coupled to ICP-MS.

    Science.gov (United States)

    Heitland, Peter; Köster, Helmut D

    2018-04-01

    Most of the Se in human serum is bound to selenoprotein P (SEPP1) in which Se is present in form of selenocysteine. The SEPP1 is a new possible biomarker for the Se status and for this reason we developed a fast, simple and reliable method for the quantitative determination of SEPP1 in serum by affinity chromatography coupled to ICP-MS. It is possible to separate SEPP1 from other selenoproteins in serum in only 5 min, which allows high sample throughput in clinical laboratories. Measured and certified concentrations of total Se and Se(SEPP1) are in good agreement for the reference material SRM 1950. The SEPP1 concentration was stable in serum samples of 3 persons for a minimum of 2 weeks. Further results of method validation were described including internal and external quality assurance. The analytical method was applied for a biomonitoring study of the SEPP1 and total Se concentration in human serum of 50 occupationally non-exposed persons living in northern Germany. Concentration ranges and mean concentrations for Se(SEPP1) are 31.1-59.7 and 46.2 μg/L, respectively. The corresponding values for total Se are 62-120 and 83.5 μg/L. The mean percentage of total Se in serum present as SEPP1 is 58%. Copyright © 2018 Elsevier GmbH. All rights reserved.

  20. Investigation of the high temperature behaviour of an unsteady crack growth in 16MND5 steel and application to the calculation of vessel bottom failure in case of severe accident

    International Nuclear Information System (INIS)

    Tardif, N.

    2009-01-01

    This research thesis deals with the prediction of the failure of a pressurized water reactor under an accidental thermo-mechanical loading. This study is based on tests performed on an instrumented mock-up and on the comparison of experimental results obtained on two different 16MND15 steel grades with numerical simulation results. The test model is a tube submitted to tension and inner pressure. Temperatures, strains and pressure are measured and images are acquired by two rapid digital cameras and an infrared camera. Crack initiation and propagation conditions are acquired. Simulations are performed using finite elements and the ABAQUS code. Crack initiation and growth are modelled by a cohesive area method. Strain rates are also studied

  1. Omamoodi ime - ilmunud on eesti-läti sõnaraamat / Lembit Vaba

    Index Scriptorium Estoniae

    Vaba, Lembit 1945-

    2015-01-01

    Arvustus: Igauņu-latviešu vārdnīca / Latviešu valodas aģentūra ; sastādītāji: Valts Ernštreits, Marika Muzikante, Maima Grīnberga = Eesti-läti sõnaraamat / Läti keele agentuur ; koostajad: Valts Ernštreits, Marika Muzikante, Maima Grīnberga. Rīga ; Tallinn : Eesti Keele Sihtasutus, 2015

  2. Selenoprotein P is the essential selenium transporter for bones.

    Science.gov (United States)

    Pietschmann, Nicole; Rijntjes, Eddy; Hoeg, Antonia; Stoedter, Mette; Schweizer, Ulrich; Seemann, Petra; Schomburg, Lutz

    2014-05-01

    Selenium (Se) plays an important role in bone physiology as best reflected by Kashin-Beck disease, an endemic Se-dependent osteoarthritis. Bone development is delayed in children with mutations in SECIS binding protein 2 (SBP2), a central factor for selenoprotein biosynthesis. Circulating selenoprotein P (SePP) is positively associated with bone turnover in humans, yet its function for bone homeostasis is not known. We have analysed murine models of altered Se metabolism. Most of the known selenoprotein genes and factors needed for selenoprotein biosynthesis are expressed in bones. Bone Se is not associated with the mineral but exclusively with the organic matrix. Genetic ablation of Sepp-expression causes a drastic decline in serum (25-fold) but only a mild reduction in bone (2.5-fold) Se concentrations. Cell-specific expression of a SePP transgene in hepatocytes efficiently restores bone Se levels in Sepp-knockout mice. Of the two known SePP receptors, Lrp8 was detected in bones while Lrp2 was absent. Interestingly, Lrp8 mRNA concentrations were strongly increased in bones of Sepp-knockout mice likely in order to counteract the developing Se deficiency. Our data highlight SePP as the essential Se transporter to bones, and suggest a novel feedback mechanism for preferential uptake of Se in Se-deprived bones, thereby contributing to our understanding of hepatic osteodystrophy and the consistent bone phenotype observed in subjects with inherited selenoprotein biosynthesis mutations.

  3. Guidelines for the preclinical in vivo evaluation of pharmacological active drugs for ALS/MND: report on the 142nd ENMC international workshop.

    Science.gov (United States)

    Ludolph, Albert C; Bendotti, Caterina; Blaugrund, Eran; Hengerer, Bastian; Löffler, Jean-Philippe; Martin, Joanne; Meininger, Vincent; Meyer, Thomas; Moussaoui, Saliha; Robberecht, Wim; Scott, Sean; Silani, Vincenzo; Van Den Berg, Leonard H

    2007-08-01

    A transgenic animal model for anterior horn cell loss was established in 1994. This model is based on the insertion of a high copy number of disease-causing human Cu/Zn SOD mutations into the intact mouse genome. It serves to establish hypotheses for the pathogenesis of anterior horn cell death, but also to test potential pharmacological approaches to therapy in human ALS. Today, more than 100 -- published and unpublished -- compounds have been tested in this animal model, a large part of them being reported as successful. However, it proved to be difficult to translate these therapeutic successes in the animal model into human trials. Also, a number of disease-modifying strategies were difficult to reproduce, even by the same group. On the other hand, the step from mice to men means a huge investment for the sponsors of clinical trials and the scientific community. Therefore, establishment of standard methods for drug testing in ALS models is mandatory. In this workshop, clinical and preclinical researchers established in the field of ALS/MND met in Holland in March 2006 in order to establish guidelines for the community for drug testing in mouse models.

  4. A micro-mechanical analysis and an experimental characterisation of the behavior and the damaging processes of a 16MND5 pressure vessel steel at low temperature; Etude micromecanique et caracterisation experimentale du comportement et de l'endommagement de l'acier de cuve 16MND5 a basses temperatures

    Energy Technology Data Exchange (ETDEWEB)

    Pesci, R

    2004-06-15

    As part of an important experimental and numerical research program launched by Electricite De France on the 16MND5 pressure vessel steel, sequenced and in-situ tensile tests are realized at low temperatures [-196 C;-60 C]. They enable to associate the observation of specimens, the complete cartography of which has been made with a scanning electron microscope (damaging processes, initiation and propagation of microcracks), with the stress states determined by X-ray diffraction, in order to establish relevant criteria. All these measurements enable to supply a two-scale polycrystalline modeling of behavior and damage (Mori-Tanaka/self-consistent) which is developed concurrently with the experimental characterization. This model proves to be a very efficient one, since it correctly reproduces the influence of temperature experimentally defined: the stress state in ferrite remains less important than in bainite (the difference never exceeds 150 MPa), whereas it is much higher in cementite. The heterogeneity of strains and stresses for each crystallographic orientation is well rendered; so is cleavage fracture normal to the {l_brace}100{r_brace} planes in ferrite (planes identified by electron back scattered diffraction during an in-situ tensile test at -150 C), which occurs sooner when temperature decreases, for a constant stress of about 700 MPa in this phase. (author)

  5. "Anything that makes life's journey better." Exploring the use of digital technology by people living with motor neurone disease.

    Science.gov (United States)

    Hobson, Esther V; Fazal, Saima; Shaw, Pamela J; McDermott, Christopher J

    2017-08-01

    Our aim was to explore the attitudes of those living with motor neuron disease towards digital technology. Postal and online questionnaires surveyed 83 people with MND (pwMND) and 54 friends and family members (fMND). Five pwMND and five fMND underwent semi-structured interviews. 82% of pwMND and 87% of fMND use technology every day with iPads and laptops being the devices most commonly used. pwMND used technology to help them continue to participate in everyday activities such as socialising, entertainment and accessing the internet. The internet provided peer support and information about MND but information could be distressing or unreliable. Participants preferred information from professionals and official organisations. Participants were generally supportive of using of technology to access medical care. Barriers to technology, such as lack of digital literacy skills and upper limb dysfunction, and potential solutions were identified. More challenging barriers included language and cognitive difficulties, and the fear of becoming dependent on technology. Addressing the barriers identified in this research could help pwMND access technology. However, as healthcare delivery becomes more reliant on digital technology, care should be taken to ensure that those who are unable or unwilling to use technology continue to have their needs met in alternative ways.

  6. Heavy metals in locus ceruleus and motor neurons in motor neuron disease.

    Science.gov (United States)

    Pamphlett, Roger; Kum Jew, Stephen

    2013-12-12

    The causes of sporadic amyotrophic lateral sclerosis (SALS) and other types of motor neuron disease (MND) remain largely unknown. Heavy metals have long been implicated in MND, and it has recently been shown that inorganic mercury selectively enters human locus ceruleus (LC) and motor neurons. We therefore used silver nitrate autometallography (AMG) to look for AMG-stainable heavy metals (inorganic mercury and bismuth) in LC and motor neurons of 24 patients with MND (18 with SALS and 6 with familial MND) and in the LC of 24 controls. Heavy metals in neurons were found in significantly more MND patients than in controls when comparing: (1) the presence of any versus no heavy metal-containing LC neurons (MND 88%, controls 42%), (2) the median percentage of heavy metal-containing LC neurons (MND 9.5%, control 0.0%), and (3) numbers of individuals with heavy metal-containing LC neurons in the upper half of the percentage range (MND 75%, controls 25%). In MND patients, 67% of remaining spinal motor neurons contained heavy metals; smaller percentages were found in hypoglossal, nucleus ambiguus and oculomotor neurons, but none in cortical motor neurons. The majority of MND patients had heavy metals in both LC and spinal motor neurons. No glia or other neurons, including neuromelanin-containing neurons of the substantia nigra, contained stainable heavy metals. Uptake of heavy metals by LC and lower motor neurons appears to be fairly common in humans, though heavy metal staining in the LC, most likely due to inorganic mercury, was seen significantly more often in MND patients than in controls. The LC innervates many cell types that are affected in MND, and it is possible that MND is triggered by toxicant-induced interactions between LC and motor neurons.

  7. Heavy metals in locus ceruleus and motor neurons in motor neuron disease

    Science.gov (United States)

    2013-01-01

    Background The causes of sporadic amyotrophic lateral sclerosis (SALS) and other types of motor neuron disease (MND) remain largely unknown. Heavy metals have long been implicated in MND, and it has recently been shown that inorganic mercury selectively enters human locus ceruleus (LC) and motor neurons. We therefore used silver nitrate autometallography (AMG) to look for AMG-stainable heavy metals (inorganic mercury and bismuth) in LC and motor neurons of 24 patients with MND (18 with SALS and 6 with familial MND) and in the LC of 24 controls. Results Heavy metals in neurons were found in significantly more MND patients than in controls when comparing: (1) the presence of any versus no heavy metal-containing LC neurons (MND 88%, controls 42%), (2) the median percentage of heavy metal-containing LC neurons (MND 9.5%, control 0.0%), and (3) numbers of individuals with heavy metal-containing LC neurons in the upper half of the percentage range (MND 75%, controls 25%). In MND patients, 67% of remaining spinal motor neurons contained heavy metals; smaller percentages were found in hypoglossal, nucleus ambiguus and oculomotor neurons, but none in cortical motor neurons. The majority of MND patients had heavy metals in both LC and spinal motor neurons. No glia or other neurons, including neuromelanin-containing neurons of the substantia nigra, contained stainable heavy metals. Conclusions Uptake of heavy metals by LC and lower motor neurons appears to be fairly common in humans, though heavy metal staining in the LC, most likely due to inorganic mercury, was seen significantly more often in MND patients than in controls. The LC innervates many cell types that are affected in MND, and it is possible that MND is triggered by toxicant-induced interactions between LC and motor neurons. PMID:24330485

  8. Amygdala TDP-43 Pathology in Frontotemporal Lobar Degeneration and Motor Neuron Disease.

    Science.gov (United States)

    Takeda, Takahiro; Seilhean, Danielle; Le Ber, Isabelle; Millecamps, Stéphanie; Sazdovitch, Véronique; Kitagawa, Kazuo; Uchihara, Toshiki; Duyckaerts, Charles

    2017-09-01

    TDP-43-positive inclusions are present in the amygdala in frontotemporal lobar degeneration (FTLD) and motor neuron disease (MND) including amyotrophic lateral sclerosis. Behavioral abnormalities, one of the chief symptoms of FTLD, could be, at least partly, related to amygdala pathology. We examined TDP-43 inclusions in the amygdala of patients with sporadic FTLD/MND (sFTLD/MND), FTLD/MND with mutation of the C9ORF72 (FTLD/MND-C9) and FTLD with mutation of the progranulin (FTLD-GRN). TDP-43 inclusions were common in each one of these subtypes, which can otherwise be distinguished on topographical and genetic grounds. Conventional and immunological stainings were performed and we quantified the numerical density of inclusions on a regional basis. TDP-43 inclusions in amygdala could be seen in 10 out of 26 sFTLD/MND cases, 5 out of 9 FTLD/MND-C9 cases, and all 4 FTLD-GRN cases. Their numerical density was lower in FTLD/MND-C9 than in sFTLD/MND and FTLD-GRN. TDP-43 inclusions were more numerous in the ventral region of the basolateral nucleus group in all subtypes. This contrast was apparent in sporadic and C9-mutated FTLD/MND, while it was less evident in FTLD-GRN. Such differences in subregional involvement of amygdala may be related to the region-specific neuronal connections that are differentially affected in FTLD/MND and FTLD-GRN. © 2017 American Association of Neuropathologists, Inc. All rights reserved.

  9. Micro-mechanical analysis and modelling of the behavior and brittle fracture of a french 16MND5 steel: role of microstructural heterogeneities; Analyse et modelisation micromecanique du comportement et de la rupture fragile de l'acier 16MND5: prise en compte des heterogeneites microstructurales

    Energy Technology Data Exchange (ETDEWEB)

    Mathieu, J.Ph

    2006-10-15

    Reactor Pressure Vessel is the second containment barrier between nuclear fuel and the environment. Electricite de France's reactors are made with french 16MND5 low-alloyed steel (equ. ASTM A508 Cl.3). Various experimental techniques (scanning electron microscopy, X-ray diffraction...) are set up in order to characterize mechanical heterogeneities inside material microstructure during tensile testing at different low temperatures [-150 C;-60 C]. Heterogeneities can be seen as the effect of both 'polycrystalline' and 'composite' microstructural features. Interphase (until 150 MPa in average between ferritic and bainitic macroscopic stress state) and intra-phase (until 100 MPa in average between ferritic orientations) stress variations are highlighted. Modelling involves micro-mechanical description of plastic glide, mean fields models and realistic three-dimensional aggregates, all put together inside a multi-scale approach. Calibration is done on macroscopic stress-strain curves at different low temperatures, and modelling reproduces experimental stress heterogeneities. This modelling allows to apply a local micro-mechanical fracture criterion for crystallographic cleavage. Deterministic computations of time to fracture for different carbides random selection provide a way to express probability of fracture for the elementary volume. Results are in good agreement with hypothesis made by local approach to fracture. Hence, the main difference is that no dependence to loading nor microstructure features is supposed for probability of fracture on the representative volume: this dependence is naturally introduced by modelling. (author)

  10. Micro-mechanical analysis and modelling of the behavior and brittle fracture of a french 16MND5 steel: role of microstructural heterogeneities

    International Nuclear Information System (INIS)

    Mathieu, J.Ph.

    2006-10-01

    Reactor Pressure Vessel is the second containment barrier between nuclear fuel and the environment. Electricite de France's reactors are made with french 16MND5 low-alloyed steel (equ. ASTM A508 Cl.3). Various experimental techniques (scanning electron microscopy, X-ray diffraction...) are set up in order to characterize mechanical heterogeneities inside material microstructure during tensile testing at different low temperatures [-150 C;-60 C]. Heterogeneities can be seen as the effect of both 'polycrystalline' and 'composite' microstructural features. Interphase (until 150 MPa in average between ferritic and bainitic macroscopic stress state) and intra-phase (until 100 MPa in average between ferritic orientations) stress variations are highlighted. Modelling involves micro-mechanical description of plastic glide, mean fields models and realistic three-dimensional aggregates, all put together inside a multi-scale approach. Calibration is done on macroscopic stress-strain curves at different low temperatures, and modelling reproduces experimental stress heterogeneities. This modelling allows to apply a local micro-mechanical fracture criterion for crystallographic cleavage. Deterministic computations of time to fracture for different carbides random selection provide a way to express probability of fracture for the elementary volume. Results are in good agreement with hypothesis made by local approach to fracture. Hence, the main difference is that no dependence to loading nor microstructure features is supposed for probability of fracture on the representative volume: this dependence is naturally introduced by modelling. (author)

  11. Nonmotor symptoms in patients suffering from motor neuron diseases

    Directory of Open Access Journals (Sweden)

    Rene Günther

    2016-07-01

    Full Text Available Background: The recently postulated disease spreading hypothesis has gained much attention, especially for Parkinson’s disease (PD. The various nonmotor symptoms (NMS in neurodegenerative diseases would be much better explained by this hypothesis than by the degeneration of disease-specific cell populations. Motor neuron disease (MND is primarily known as a group of diseases with a selective loss of motor function. Recent evidence, however, suggests disease spreading into nonmotor brain regions also in MND. The aim of this study was to comprehensively detect NMS in patients suffering from MND.Methods: We used a self-rating questionnaire including 30 different items of gastrointestinal, autonomic, neuropsychiatric and sleep complaints (NMSQuest which is an established tool in PD patients. 90 MND patients were included and compared to 96 controls.Results: In total, MND patients reported significantly higher NMS scores (median: 7 points in comparison to controls (median: 4 points. Dribbling, impaired taste/smelling, impaired swallowing, weight loss, loss of interest, sad/blues, falling and insomnia were significantly more prevalent in MND patients compared to controls. Interestingly excessive sweating was more reported in the MND group. Correlation analysis revealed an increase of total NMS score with disease progression.Conclusions: NMS in MND patients seemed to increase with disease progression which would fit with the recently postulated disease spreading hypothesis. The total NMS score in the MND group significantly exceeded the score for the control group, but only 8 of the 30 single complaints of the NMSQuest were significantly more often reported by MND patients. Dribbling, impaired swallowing, weight loss and falling could primarily be connected to motor neuron degeneration and declared as motor symptoms in MND.

  12. Non-Motor Symptoms in Patients Suffering from Motor Neuron Diseases.

    Science.gov (United States)

    Günther, René; Richter, Nicole; Sauerbier, Anna; Chaudhuri, Kallol Ray; Martinez-Martin, Pablo; Storch, Alexander; Hermann, Andreas

    2016-01-01

    The recently postulated "disease spreading hypothesis" has gained much attention, especially for Parkinson's disease (PD). The various non-motor symptoms (NMS) in neurodegenerative diseases would be much better explained by this hypothesis than by the degeneration of disease-specific cell populations. Motor neuron disease (MND) is primarily known as a group of diseases with a selective loss of motor function. However, recent evidence suggests disease spreading into non-motor brain regions also in MND. The aim of this study was to comprehensively detect NMS in patients suffering from MND. We used a self-rating questionnaire including 30 different items of gastrointestinal, autonomic, neuropsychiatric, and sleep complaints [NMS questionnaire (NMSQuest)], which is an established tool in PD patients. 90 MND patients were included and compared to 96 controls. In total, MND patients reported significantly higher NMS scores (median: 7 points) in comparison to controls (median: 4 points). Dribbling, impaired taste/smelling, impaired swallowing, weight loss, loss of interest, sad/blues, falling, and insomnia were significantly more prevalent in MND patients compared to controls. Interestingly, excessive sweating was more reported in the MND group. Correlation analysis revealed an increase of total NMS score with disease progression. NMS in MND patients seemed to increase with disease progression, which would fit with the recently postulated "disease spreading hypothesis." The total NMS score in the MND group significantly exceeded the score for the control group, but only 8 of the 30 single complaints of the NMSQuest were significantly more often reported by MND patients. Dribbling, impaired swallowing, weight loss, and falling could primarily be connected to motor neuron degeneration and declared as motor symptoms in MND.

  13. Navodnenija v umah zactroishtshikov / Maris Kuuda

    Index Scriptorium Estoniae

    Kuuda, Maris

    2007-01-01

    Kohalikel omavalitsustel pole piisavalt hoobasid sundida arendajaid üleujutusohuga arvestama. Pärnusse hotelli September rajajad (arhitektid Emil Urbel, Andrus Mark) arvestavad ujutusohuga. Arvamust avaldavad Rene Reisner, Mari Sepp, Ülo Sults, Karri Tiigisoon, Indrek Rannik, Mark Soosaar, Tiiu Pärn, Merle Looring, Rita Sepp, Kaspar Alles

  14. Relationship between 3-Methyl-2,4-nonanedione Concentration and Intensity of Light-induced Off-odor in Soy Bean Oil.

    Science.gov (United States)

    Sano, Takashi; Iwahashi, Maiko; Imagi, Jun; Sato, Toshiro; Yamashita, Toshiyuki; Fukusaki, Eiichiro; Bamba, Takeshi

    2016-05-01

    A beany and green off-odor is developed in soy bean oil (SBO) under light-induced oxidative conditions. 3-Methyl-2,4-nonanedione (3-MND) was inferred as the compound responsible for the off-odor. In this study, we designed a simple quantification method for 3-MND in SBO, and evaluated the relationship between the 3-MND concentration and the intensity of the off-odor. 3-MND was analyzed by GC/MS with a thermal desorption unit system. By our method, the 3-MND concentration was found to increase with storage days and the SBO content under light exposure, and there was a high correlation between the measured 3-MND concentration and the intensity of the light-induced off-odor in SBO (R = 0.9586).

  15. Valik konkursi "Noored poeedid 2009" alapealkirjaga "See on rõõm elust endast" tunnustust pälvinud töödest : [luuletused

    Index Scriptorium Estoniae

    2009-01-01

    Vanem vanuseaste 1. koht Triin Sepp, 2. koht Triinu Ansper, 3.-4. koht Kairi Sepp ja Heli Armus. Keskmine vanuseaste 1. koht Annaliis Lehto, 2. koht Liina Salonen, 3. koht Gerda-Liis Palmiste. Noorem vanuseaste 1. koht Reet Rüütel, 2. koht Diana Kasesalu, 3. koht Eliis Mets

  16. Controle de Cerconota anonella (Sepp. (Lep.: Oecophoridae e de Bephratelloides pomorum (Fab. (Hym.: Eurytomidae em frutos de pinha (Annona squamosa L.

    Directory of Open Access Journals (Sweden)

    Letice Souza da Silva

    2014-01-01

    Full Text Available A pinha, Annona squamosa L., é uma frutífera tropical da família anonácea, cujo mercado tem-se ampliado a cada ano, sendo cultivada expressivamente na região Nordeste, onde pequenos produtores a têm como principal fonte de renda. Entretanto, problemas causados pelas duas pragas-chave, Cerconota anonella (Sepp.,1830 (Lepidoptera: Oecophoridae e Bephratelloides pomorum (Fab.,1808 (Hymenoptera: Eurytomidae, têm limitado a produção e, consequentemente, a comercialização dos frutos. No intuito de minimizar essas perdas, um experimento de campo foi realizado em Maceió, Estado de Alagoas, Brasil, para avaliar diferentes formas de controle para estas pragas. O experimento foi conduzido no delineamento em blocos casualizados, com oito tratamentos e quatro repetições. Cada repetição correspondeu a quatro frutos, totalizando dezesseis frutos por tratamento. Os tratamentos foram: frutos sem proteção (testemunha; saco de papel branco impermeável aberto; saco plástico microperfurado; saco de TNT (tecido não tecido branco aberto; saco de TNT vermelho aberto; gaiola de arame revestida com tecido voile; inseticida Profenofós (12g/L-1 + Cipermetrina (1,2 g/L-1 e caulim (10 g/ 100 mL-1. Foram avaliadas as seguintes variáveis nos frutos: números de orifícios causados pelas pragas, peso, comprimento, diâmetro, percentagem de frutos colhidos e o custo do tratamento por unidade. Os melhores resultados foram obtidos com o saco de TNT vermelho aberto, obtendo-se 87,50% de frutos comercializáveis. O saco plástico microperfurado teve o menor custo, porém sua fragilidade impede a reutilização nas safras seguintes. Assim, indica-se o saco de TNT vermelho aberto como o mais econômico e eficiente.

  17. Selenoprotein P Inhibits Radiation-Induced Late Reactive Oxygen Species Accumulation and Normal Cell Injury

    Energy Technology Data Exchange (ETDEWEB)

    Eckers, Jaimee C.; Kalen, Amanda L.; Xiao, Wusheng; Sarsour, Ehab H.; Goswami, Prabhat C., E-mail: prabhat-goswami@uiowa.edu

    2013-11-01

    Purpose: Radiation is a common mode of cancer therapy whose outcome is often limited because of normal tissue toxicity. We have shown previously that the accumulation of radiation-induced late reactive oxygen species (ROS) precedes cell death, suggesting that metabolic oxidative stress could regulate cellular radiation response. The purpose of this study was to investigate whether selenoprotein P (SEPP1), a major supplier of selenium to tissues and an antioxidant, regulates late ROS accumulation and toxicity in irradiated normal human fibroblasts (NHFs). Methods and Materials: Flow cytometry analysis of cell viability, cell cycle phase distribution, and dihydroethidium oxidation, along with clonogenic assays, were used to measure oxidative stress and toxicity. Human antioxidant mechanisms array and quantitative real-time polymerase chain reaction assays were used to measure gene expression during late ROS accumulation in irradiated NHFs. Sodium selenite addition and SEPP1 overexpression were used to determine the causality of SEPP1 regulating late ROS accumulation and toxicity in irradiated NHFs. Results: Irradiated NHFs showed late ROS accumulation (4.5-fold increase from control; P<.05) that occurs after activation of the cell cycle checkpoint pathways and precedes cell death. The mRNA levels of CuZn- and Mn-superoxide dismutase, catalase, peroxiredoxin 3, and thioredoxin reductase 1 increased approximately 2- to 3-fold, whereas mRNA levels of cold shock domain containing E1 and SEPP1 increased more than 6-fold (P<.05). The addition of sodium selenite before the radiation treatment suppressed toxicity (45%; P<.05). SEPP1 overexpression suppressed radiation-induced late ROS accumulation (35%; P<.05) and protected NHFs from radiation-induced toxicity (58%; P<.05). Conclusion: SEPP1 mitigates radiation-induced late ROS accumulation and normal cell injury.

  18. The current perception threshold test differentiates categories of mechanical neck disorder.

    Science.gov (United States)

    Uddin, Zakir; MacDermid, Joy C; Galea, Victoria; Gross, Anita R; Pierrynowski, Michael R

    2014-07-01

    Cross-sectional discriminative analysis. To determine whether current perception threshold (CPT) can differentiate between categories of patients with mechanical neck disorders (MNDs). Neck pain is the third most common musculoskeletal disorder and affects a third of all adults each year. It can present as neck pain without musculoskeletal signs, neck pain with musculoskeletal signs but no neurological signs, or neck pain with neurological signs. CPT testing can assess altered sensory perception that may reflect neurological changes. Patients with MNDs (n = 106) were classified into 3 groups, based on a standardized musculoskeletal examination process performed by an experienced physiotherapist who was blinded to CPT scores. The 3 groups were defined as neck pain without musculoskeletal signs (MND I) (n = 60), neck pain with musculoskeletal signs (MND II) (n = 29), and neck pain with neurological signs (MND III) (n = 17). A rapid protocol of CPT testing was performed at 3 frequencies (5, 250, and 2000 Hz), using 3 dermatomal locations on the hand. A 1-way analysis of variance with post hoc comparison and effect sizes was calculated to compare the mean CPT scores between the groups. A binary logistic-regression model was used to predict probability of higher CPT in MND III and to create a receiver-operating-characteristic curve. Mean CPT differed significantly across the 3 MND groups (MND I, 9.7; MND II, 10.6; and MND III, 11.8; Pabnormal CPT in MND III had an estimated 73% sensitivity and 81% specificity; the odds ratio was 11.5 (P = .001) for the differentiation capacity of CPT between MND II and III, with a cutoff of 11. The area under the receiver-operating-characteristic curve was 0.84 (95% confidence interval: 0.72, 0.96; P<.001). CPT testing has moderate discriminatory accuracy, specificity, and sensitivity for classification of MND categories into neck pain with or without neurological signs. J Orthop Sports Phys Ther 2014;44(7):532-540. Epub 10 May 2014

  19. Two Studies on Twitter Networks and Tweet Content in Relation to Amyotrophic Lateral Sclerosis (ALS): Conversation, Information, and 'Diary of a Daily Life'.

    Science.gov (United States)

    Hemsley, Bronwyn; Palmer, Stuart

    2016-01-01

    To date, there is no research examining how adults with Amyotrophic Lateral Sclerosis (ALS) or Motor Neurone Disease (MND) and severe communication disability use Twitter, nor the use of Twitter in relation to ALS/MND beyond its use for fundraising and raising awareness. In this paper we (a) outline a rationale for the use of Twitter as a method of communication and information exchange for adults with ALS/MND, (b) detail multiple qualitative and quantitative methods used to analyse Twitter networks and tweet content in the our studies, and (c) present the results of two studies designed to provide insights on the use of Twitter by an adult with ALS/MND and by #ALS and #MND hashtag communities in Twitter. We will also discuss findings across the studies, implications for health service providers in Twitter, and directions for future Twitter research in relation to ALS/MND.

  20. Study Paths, Riemann Surfaces, and Strebel Differentials

    Science.gov (United States)

    Buser, Peter; Semmler, Klaus-Dieter

    2017-01-01

    These pages aim to explain and interpret why the late Mika Seppälä, a conformal geometer, proposed to model student study behaviour using concepts from conformal geometry, such as Riemann surfaces and Strebel differentials. Over many years Mika Seppälä taught online calculus courses to students at Florida State University in the United States, as…

  1. Fourth Generation War: Paradigm for Change

    Science.gov (United States)

    2005-06-01

    PARADIGM FOR CHANGE by Ghanshyam Singh Katoch June 2005 Thesis Advisor : Kalev Sepp Second Reader...Approved by: Kalev Sepp Thesis Advisor Douglas Borer Second Reader Gordon McCormick Chairman, Department of Defense...combination of all the resources of the government, not just the army. d. Economy of Effort A Robo -Soldier is a small, tracked, electrically powered vehicle

  2. Ilmub raamat viikingiajast Saaremaal / Pamela Talzi

    Index Scriptorium Estoniae

    Talzi, Pamela

    2017-01-01

    Saaremaal viikingiaega uurinud arheoloogi, Tallinna ülikooli humanitaarteaduste instituudi ajaloo, arheoloogia ja kunstiajaloo keskuse vanemteaduri Marika Mägi sulest ilmub raamat "Viikingiaegne Eesti"

  3. A Dutch family with autosomal recessively inherited lower motor neuron predominant motor neuron disease due to optineurin mutations

    NARCIS (Netherlands)

    Beeldman, Emma; van der Kooi, Anneke J.; de Visser, Marianne; van Maarle, Merel C.; van Ruissen, Fred; Baas, Frank

    2015-01-01

    Approximately 10% of motor neuron disease (MND) patients report a familial predisposition for MND. Autosomal recessively inherited MND is less common and is most often caused by mutations in the superoxide dismutase 1 (SOD1) gene. In 2010, autosomal recessively inherited mutations in the optineurin

  4. The assessment of minor neurological dysfunction in infancy using the Touwen Infant Neurological Examination : strengths and limitations

    NARCIS (Netherlands)

    Hadders-Algra, Mijna; Heineman, Kirsten R.; Bos, Arend F.; Middelburg, Karin J.

    Aim Little is known of minor neurological dysfunction (MND) in infancy. This study aimed to evaluate the inter-assessor reliability of the assessment of MND with the Touwen Infant Neurological Examination (TINE) and the construct and predictive validity of MND in infancy. Method Inter-assessor

  5. Computational Analysis of Pharyngeal Swallowing Mechanics in Patients with Motor Neuron Disease: A Pilot Investigation.

    Science.gov (United States)

    Garand, K L; Schwertner, Ryan; Chen, Amy; Pearson, William G

    2018-04-01

    Swallowing impairment (dysphagia) is a common sequela in patients with motor neuron disease (MND). The purpose of this retrospective, observational pilot investigation was to characterize how pharyngeal swallowing mechanics are impacted in patients with MND using a comparison with healthy, non-dysphagic control group. Computational analysis of swallowing mechanics (CASM) was used to determine covariate biomechanics of pharyngeal swallowing from videofluoroscopic assessment in 15 patients with MND and 15 age- and sex-matched healthy controls. Canonical variant analysis with post hoc discriminate function analysis (DFA) was performed on coordinate data mapping functional muscle groups underlying pharyngeal swallowing. Differences in swallowing mechanics associated with group (MND; control), motor neuron predominance (upper; lower), onset (bulbar; spinal), and swallow task (thin, pudding) were evaluated and visualized. Pharyngeal swallowing mechanics differed significantly in patients with MND compared with healthy controls (D = 2.01, p mechanics by motor neuron predominance (D = 5.03, p mechanics of patients with MND differ from and are more heterogeneous than healthy controls. These findings suggest patients with MND may compensate reductions in pharyngeal shortening and tongue base retraction by extending the head and neck and increasing hyolaryngeal excursion. This work and further CASM investigations will lead to further insights into development and evaluation of targeted clinical treatments designed to prolong safe and efficient swallowing function in patients with MND.

  6. WAIS Digit Span-Based Indicators of Malingered Neurocognitive Dysfunction: Classification Accuracy in Traumatic Brain Injury

    Science.gov (United States)

    Heinly, Matthew T.; Greve, Kevin W.; Bianchini, Kevin J.; Love, Jeffrey M.; Brennan, Adrianne

    2005-01-01

    The present study determined specificity and sensitivity to malingered neurocognitive dysfunction (MND) in traumatic brain injury (TBI) for several Wechsler Adult Intelligence Scale (WAIS) Digit Span scores. TBI patients (n = 344) were categorized into one of five groups: no incentive, incentive only, suspect, probable MND, and definite MND.…

  7. Communications Technology and Motor Neuron Disease: An Australian Survey of People With Motor Neuron Disease.

    Science.gov (United States)

    Mackenzie, Lynette; Bhuta, Prarthna; Rusten, Kim; Devine, Janet; Love, Anna; Waterson, Penny

    2016-01-25

    People with Motor Neuron Disease (MND), of which amyotrophic lateral sclerosis (ALS) is the most common form in adults, typically experience difficulties with communication and disabilities associated with movement. Assistive technology is essential to facilitate everyday activities, promote social support and enhance quality of life. This study aimed to explore the types of mainstream and commonly available communication technology used by people with MND including software and hardware, to identify the levels of confidence and skill that people with MND reported in using technology, to determine perceived barriers to the use of technology for communication, and to investigate the willingness of people with MND to adopt alternative modes of communication. An on-line survey was distributed to members of the New South Wales Motor Neuron Disease Association (MND NSW). Descriptive techniques were used to summarize frequencies of responses and cross tabulate data. Free-text responses to survey items and verbal comments from participants who chose to undertake the survey by telephone were analyzed using thematic analysis. Responses from 79 MND NSW members indicated that 15-21% had difficulty with speaking, writing and/or using a keyboard. Commonly used devices were desktop computers, laptops, tablets and mobile phones. Most participants (84%) were connected to the Internet and used it for email (91%), to find out more about MND (59%), to follow the news (50%) or for on-line shopping (46%). A third of respondents used Skype or its equivalent, but few used this to interact with health professionals. People with MND need greater awareness of technology options to access the most appropriate solutions. The timing for people with MND to make decisions about technology is critical. Health professionals need skills and knowledge about the application of technology to be able to work with people with MND to select the best communication technology options as early as possible

  8. MINOR NEUROLOGICAL DYSFUNCTION AFTER THE ONSET OF PUBERTY - ASSOCIATION WITH PERINATAL EVENTS

    NARCIS (Netherlands)

    SOORANILUNSING, RJ; HADDERSALGRA, M; HUISJES, HJ; TOUWEN, BCL

    In order to study the hypotheses that puberty is related to a decrease of minor neurological dysfunction (MND) and that persisting MND is associated with perinatal factors, two groups (174 normal, 172 MND) of the Groningen Perinatal Project were followed from 12 to 14 years. At 14 years almost all

  9. Multiple nuclear dots and rim-like/membranous IgG isotypes in primary biliary cirrhosis.

    Science.gov (United States)

    Muratori, Paolo; Granito, Alessandro; Ferri, Silvia; Pappas, Georgios; Volta, Umberto; Menichella, Rita; Bianchi, Francesco B; Lenzi, Marco; Muratori, Luigi

    2009-03-01

    Anti nuclear (ANA) immunomorphological patterns such as multiple nuclear dots (MND) and rim-like/membranous (RL/M) are considered highly specific but little sensitive for primary biliary cirrhosis (PBC) diagnosis. To evaluate frequency and clinical significance of MND and RL/M in PBC patients when investigated at the level of immunoglobulin G isotypes. MND and RL/M pattern have been tested in 141 PBC sera and 230 pathological controls using HEp-2 cells as substrate and anti- total IgG and individual IgG subclasses (IgG1, IgG2, IgG3, IgG4) as specific antisera. One hundred and fourteen of 141 (80%) PBC patients had RL/M or MND pattern when IgG subclasses were used as revealing reagents (vs. 34% when anti total IgG were used, p < 0.0001). The prevalent isotype was IgG1 for RL/M, and IgG2 for MND pattern. None of controls was positive. No clinical differences in terms of severity and outcome of disease have been observed in PBC patients positive for MND and RL/M when investigated with IgG isotypes. The research for RL/M and MND pattern at level of IgG isotype determines a wide gain in terms of sensitivity without a loss of specificity. In Italian PBC patients MND and RL/M pattern did not seem to characterize any subgroup of patients with a poorer prognosis.

  10. Trends in motor neuron disease: association with latitude and air lead levels in Spain.

    Science.gov (United States)

    Santurtún, Ana; Villar, Alejandro; Delgado-Alvarado, Manuel; Riancho, Javier

    2016-08-01

    Motor neuron diseases (MND) are a group of disorders characterized by motor neuron degeneration. Among them, amyotrophic lateral sclerosis (ALS) is by far the most common in adulthood. This paper assesses the trend and geographical pattern in MND incidence in Spain and the possible air lead levels effect on this pathology. To confirm this concept, we performed a retrospective analysis of the deaths due to MND in Spain during 2000 and 2013, determined the geographical differences, and explored the relationship between MND and the air levels of lead. Overall, between 2000 and 2013, 11,355 people died in Spain because of MND. Disease mortality significantly increased in recent years (2007-2013) when compared with the first time of the period. Spearman's rank correlation coefficient also showed a statistically significant positive trend (CC = 0.824, p = 0.0002). Among people over 65 years, mortality rates were higher in Northern provinces. Moreover, we found a significant association of MND mortality with higher air lead levels (CC = 0.457, p = 0.01). Our study confirms that MND mortality is increasing in Spain, with a significant latitude gradient, which suggests an important role of environmental exposures. This ecological study suggests that air lead levels may be implicated in ALS pathogenesis.

  11. Hematological Parameters and the State of Liver Cells of Rats After Oral Administration of Aflatoxin B1 Alone and Together with Nanodiamonds

    Directory of Open Access Journals (Sweden)

    Baron AV

    2010-01-01

    Full Text Available Abstract Hematological parameters and the state of liver cells of rats were examined in vivo after the animals received aflatoxin B1 (AfB1 alone and together with modified nanodiamonds (MND synthesized by detonation. The rats that had received the MND hydrosol had elevated leukocyte levels, mainly due to higher granulocyte counts and somewhat increased monocyte counts compared to control rats. Hematological parameters of the rats that had received AfB1 alone differed from those of the control rats in another way: total white blood cell counts were significantly lower due to the decreased lymphocyte counts. In rats that had consumed AfB1 with the MND hydrosol, changes in hematological parameters were less pronounced than in rats that had consumed either AfB1 or MND. Electron microscopy showed that hepatocytes of the rats that had received the MND hydrosol or AfB1 with the MND hydrosol contained elevated levels of lipid inclusions and lysosomes. Hyperplasia of the smooth endoplasmic reticulum (EPR was revealed in liver specimens of the rats that had received AfB1. Results of the study suggest the conclusion about mutual mitigation of the effects of nanoparticles and the mycotoxin on rats blood and liver cells after AfB1 has adsorbed on MND.

  12. Motor Neurone Disease: Disability Profile and Service Needs in an Australian Cohort

    Science.gov (United States)

    Ng, Louisa; Talman, Paul; Khan, Fary

    2011-01-01

    Motor neurone disease (MND) places considerable burden upon patients and caregivers. This is the first study, which describes the disability profile and healthcare needs for persons with MND (pwMND) in an Australian sample from the perspective of the patients and caregivers to identify current gaps in the knowledge and service provision. A…

  13. Ja mul oli veel nii palju öelda! / Marju Kõivupuu

    Index Scriptorium Estoniae

    Kõivupuu, Marju, 1960-

    2006-01-01

    Ka järgmistest raamatutest: Schultz-Bertram, Georg Julius. Balti idealisti kirjad emale / tlk. Ilmar Vene. Tartu : Ilmamaa, 2003 ; Dr. Bertram. Tartu tudengid viiskümmend aastat tagasi / saksa keelest Viktor Sepp. Tallinn : Perioodika, 1999. (Loomingu Raamatukogu ; 17) ; Pärnik, Ylo M. Dr Georg Julius von Schultz-Bertram. Tartu : Ilmamaa, 2006 ; Dr. Bertram. Kolm Tartu balli / tlk. Viktor Sepp. Tallinn : Perioodika, 1990. (Loomingu Raamatukogu ; 26)

  14. Serum selenium and selenoprotein-P levels in autoimmune thyroid diseases patients in a select center: a transversal study.

    Science.gov (United States)

    Federige, Marco Aurélio Ferreira; Romaldini, João Hamilton; Miklos, Ana Beatriz Pinotti Pedro; Koike, Marcia Kiyomi; Takei, Kioko; Portes, Evandro de Souza

    2017-12-01

    Selenium (Se) supplementation has been used to help prevent the progression of Graves' ophthalmopathy (GO) and autoimmune thyroid diseases (AITD) patients. We investigated Se serum and selenoprotein P (SePP) levels in Graves' disease (GD) with and without GO, Hashimoto's thyroiditis (HT) patients and in 27 control individuals (C). We studied 54 female and 19 male patients: 19 with GD without GO, 21 GD with GO, 14 with HT and 19 with HT+LT4. Se values were measured using graphite furnace atomic absorption spectrophotometry. Serum SePP levels were measured by ELISA. Median Se levels were similar among all groups; GD patients: 54.2 (46.5-61.1 μg/L), GO: 53.6 (43.5-60.0 μg/L), HT: 51.9 (44.6-58.5 μg/L), HT+LT4 54.4 (44-63.4) and C group patients: 56.0 (52.4-61.5 μg/L); P = 0.48. However, serum SePP was lower in GO patients: 0.30 (0.15-1.05 μg/mL) and in HT patients: 0.35 (0.2-1.17 μg/mL) compared to C group patients: 1.00 (0.564.21 μg/mL) as well as to GD patients: 1.19 (0.62-2.5 μg/mL) and HT+LT4 patients: 0.7 (0,25-1.95); P = 0.002. Linear regression analysis showed a significant relationship between SePP and TPOAb values (r = 0.445, R2 = 0.293; P < 0.0001). Multiple regression analysis found no independent variables related to Se or SePP. A serum Se concentration was lower than in some other countries, but not significantly among AITD patients. The low serum SePP levels in GO and HT patients seems to express inflammatory reactions with a subsequent increase in Se-dependent protein consumption remains unclear.

  15. Effect of Furan Fatty Acids and 3-Methyl-2,4-nonanedione on Light-Induced Off-Odor in Soybean Oil.

    Science.gov (United States)

    Sano, Takashi; Okabe, Ryo; Iwahashi, Maiko; Imagi, Jun; Sato, Toshiro; Yamashita, Toshiyuki; Fukusaki, Eiichiro; Bamba, Takeshi

    2017-03-15

    Soybean oil is one of the most widely consumed vegetable oils. However, under photooxidative conditions, this oil develops a beany and green off-odor through a mechanism that has not yet been elucidated. Upon photooxidation, 3-methyl-2,4-nonanedione (3-MND) produces a strong aroma. In this study, the effect of furan fatty acids and 3-MND on odor reversion in soybean oil was investigated. Our findings suggest that the observed light-induced off-odor was likely attributable to the furan fatty acids present in the oil through the generation of 3-MND. While 3-MND may not be directly responsible for the development of light-induced off-odor, this compound appears to be involved because off-odor was detected in canola oil samples containing added 3-MND. In addition, in the present work, 3-hydroxy-3-methyl-2,4-nonanedione, which is derived from 3-MND, was identified for the first time in light-exposed soybean oil and shown to be one of the compounds responsible for odor reversion.

  16. The New Forekspank ئ Acclaimed Bank Architecture / Triin Ojari

    Index Scriptorium Estoniae

    Ojari, Triin, 1974-

    1998-01-01

    Pangahoonete ehitamisest Eestis: Eesti Pank, Hansapank, Tallinna Pank (praegu Ühispank). Pikemalt Forekspanga (praegune Optivapank) hoone ehitamisest endisesse tehasehoonesse. Arhitektid Jüri Okas ja Marika Lõoke.. Sisekujundus Tõnu Veimer.

  17. 21. X avati Kaunase kunstibiennaal "Textile 2005"

    Index Scriptorium Estoniae

    2005-01-01

    Eestist osalevad Mare Kelpmann, Marika Kööbi, Aet Ollisaar, Kadi Pajupuu, Ludmilla Svarzhevska, Hanna Tiidus, Helen Kauksi, Krista Leesi, Aune Taamal, Erika Tammpere, Milvi Thalheim ja Erle Võsa-Tangsoo

  18. Tunnustame tõenduspõhise õendusabi edendajaid / Ester Öpik, Ilme Aro

    Index Scriptorium Estoniae

    Öpik, Ester

    2014-01-01

    Tunnustati meditsiiniõdesid Tiina Freimanni, Reet Urbanit, Marika Asbergi, Tiina Tõemetsa, Kersti Viitkarit ja Ireen Bruusi Eesti Õdede Liidu poolt 2011. aastani kaitstud õendusteaduslike uurimistööde eest

  19. Stochastic energy procurement of large electricity consumer considering photovoltaic, wind-turbine, micro-turbines, energy storage system in the presence of demand response program

    International Nuclear Information System (INIS)

    Nojavan, Sayyad; Aalami, Habib allah

    2015-01-01

    Highlights: • A stochastic energy procurement cost function in presence of DRP is proposed. • The load, price and output power of PV and wind uncertainties are modeled. • Four case studies are used to assess the effects of ESS and DRP on SEPP. • Case 4 is considered the effects of ESS and DRP simultaneously. • The expected energy procurement cost of case 4 is lower than cases 1, 2 and 3. - Abstract: This paper proposes a stochastic energy procurement problem (SEPP) for large electricity consumer (LEC) with multiple energy procurement sources (EPSs) considering the effects of demand response program (DRP) and energy storage system (ESS). The EPSs contain power market (PM), bilateral contracts (BCs), micro-turbines (MTs), and renewable energy sources (RESs). Moreover, the RESs include photovoltaic (PV) systems and wind-turbines (WT). The ESS and DRP are incorporated in the SEPP by the LEC’s decision-maker to reduce the expected energy procurement cost (EEPC). Meanwhile, the uncertainty models of market price, load and RES output power are considered in the SEPP formulation. The error of forecasting of market price, load, temperature and radiation of PV systems are modeled using the normal distribution for generating the related scenarios. Also, the weibull distribution is used to generate variable wind speed scenarios for WT output power uncertainty modeling. Furthermore, the fast forward selection based on Kantorovich distance approach is used for the scenarios reduction. Finally, the influences of ESS and DRP on EEPC are investigated, and four case studies are used to illustrate the capability of the proposed SEPP. The obtained results demonstrate the efficiency of the proposed stochastic program

  20. Cerebrospinal fluid neurofilament light concentration in motor neuron disease and frontotemporal dementia predicts survival.

    Science.gov (United States)

    Skillbäck, Tobias; Mattsson, Niklas; Blennow, Kaj; Zetterberg, Henrik

    2017-08-01

    To aid diagnostics, patient stratification and studies seeking to find treatments for the related diseases motor neuron disease (MND) and frontotemporal dementia (FTD), there is a need to establish a way to assess disease severity and the amount of ongoing neurodegeneration. Previous studies have suggested that cerebrospinal fluid (CSF) neurofilament light (NFL) may serve this purpose. We cross-referenced the Swedish mortality registry with the laboratory database at Sahlgrenska University Hospital to produce a dataset of CSF NFL concentrations and mortality information for 715 MND patients, 87 FTD patients, and 107 healthy controls. Biomarker concentrations were analysed in relation to recorded cause of death and time of death. MND patients had significantly higher CSF NFL concentrations than FTD patients. Both groups had significantly higher concentrations than the healthy controls (mean 709% increase in MND and 307% increase in FTD). Higher concentrations of CSF NFL were associated with shorter survival in both MND and FTD. The results of this study strengthen the notion of CSF NFL as a useful tool for determining disease intensity in MND and FTD patients. Further studies in patient cohorts with clinically subtyped and genetically classified diagnoses are needed.

  1. Genetic epidemiology of motor neuron disease-associated variants in the Scottish population.

    Science.gov (United States)

    Black, Holly A; Leighton, Danielle J; Cleary, Elaine M; Rose, Elaine; Stephenson, Laura; Colville, Shuna; Ross, David; Warner, Jon; Porteous, Mary; Gorrie, George H; Swingler, Robert; Goldstein, David; Harms, Matthew B; Connick, Peter; Pal, Suvankar; Aitman, Timothy J; Chandran, Siddharthan

    2017-03-01

    Genetic understanding of motor neuron disease (MND) has evolved greatly in the past 10 years, including the recent identification of association between MND and variants in TBK1 and NEK1. Our aim was to determine the frequency of pathogenic variants in known MND genes and to assess whether variants in TBK1 and NEK1 contribute to the burden of MND in the Scottish population. SOD1, TARDBP, OPTN, TBK1, and NEK1 were sequenced in 441 cases and 400 controls. In addition to 44 cases known to carry a C9orf72 hexanucleotide repeat expansion, we identified 31 cases and 2 controls that carried a loss-of-function or pathogenic variant. Loss-of-function variants were found in TBK1 in 3 cases and no controls and, separately, in NEK1 in 3 cases and no controls. This study provides an accurate description of the genetic epidemiology of MND in Scotland and provides support for the contribution of both TBK1 and NEK1 to MND susceptibility in the Scottish population. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  2. Mn-doped near-infrared quantum dots as multimodal targeted probes for pancreatic cancer imaging

    Science.gov (United States)

    Yong, Ken-Tye

    2009-01-01

    This work presents a novel approach to producing manganese (Mn)-doped quantum dots (Mnd-QDs) emitting in the near-infrared (NIR). Surface functionalization of Mnd-QDs with lysine makes them stably disperse in aqueous media and able to conjugate with targeting molecules. The nanoparticles were structurally and compositionally characterized and maintained a high photoluminescence quantum yield and displayed paramagnetism in water. The receptor-mediated delivery of bioconjugated Mnd-QDs into pancreatic cancer cells was demonstrated using the confocal microscopy technique. Cytotoxicity of Mnd-QDs on live cells has been evaluated. The NIR-emitting characteristic of the QDs has been exploited to acquire whole animal body imaging with high contrast signals. In addition, histological and blood analysis of mice have revealed that no long-term toxic effects arise from MnD-QDs. These studies suggest multimodal Mnd-QDs have the potentials as probes for early pancreatic cancer imaging and detection.

  3. Patterns of Weakness, Classification of Motor Neuron Disease, and Clinical Diagnosis of Sporadic Amyotrophic Lateral Sclerosis.

    Science.gov (United States)

    Statland, Jeffrey M; Barohn, Richard J; McVey, April L; Katz, Jonathan S; Dimachkie, Mazen M

    2015-11-01

    When approaching a patient with suspected motor neuron disease (MND), the pattern of weakness on examination helps distinguish MND from other diseases of peripheral nerves, the neuromuscular junction, or muscle. MND is a clinical diagnosis supported by findings on electrodiagnostic testing. MNDs exist on a spectrum, from a pure lower motor neuron to mixed upper and lower motor neuron to a pure upper motor neuron variant. Amyotrophic lateral sclerosis (ALS) is a progressive mixed upper and lower motor neuron disorder, most commonly sporadic, which is invariably fatal. This article describes a pattern approach to identifying MND and clinical features of sporadic ALS. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. Tallinnasse Rävala pst. 19 kavandatava Tallinna Muusikakeskkooli, Tallinna Balletikooli ning G. Otsa nimelise muusikakooli ühise õppehoone arhitektuurikonkurss = Architectural Competition for the Joint School Building of Tallinn Music-Specialised

    Index Scriptorium Estoniae

    Puusepp, Raivo

    2003-01-01

    I preemia - Andres Siim, Krister Ausing, II - Marika Lõoke, III - Maia Tüür, Andres Sevtshuk, Gabriel Evangelisti, ostupreemiad: Armin Valter, Vilen Künnapu ning Siiri Vallner, Katrin Koov, Veronika Valk

  5. Eesti Vabariigiga ühevanused memmed kirjutavad presidendile / Rein Sikk

    Index Scriptorium Estoniae

    Sikk, Rein

    2007-01-01

    Neli memme, kes on sündinud 1918. a. veebruaris, Eesti Vabariigiga ühel ajal, kirjutavad ajakirjaniku vahendusel presidendile. Vt. samas: Alide Sepp: ehk saate päästa meie hooldekodu; Meeta Hütt: kaege perra, et elu oles rahulik; Milli Rump: andke pidustuste raha hoopis vaeslastele; Helmi Kõrnas: mõelge alati hästi. Sõna saavad Alide Sepp ja Helmi Kõrnas Pärnust, Meeta Hütt Võrust ja Milli Rump Väike-Maarjast

  6. Racial differences in motor neuron disease.

    Science.gov (United States)

    Gundogdu, Betul; Al-Lahham, Tawfiq; Kadlubar, Fred; Spencer, Horace; Rudnicki, Stacy A

    2014-03-01

    Our objective was to compare and contrast clinical features of black and white patients seen in the UAMS ALS/Motor Neuron Disease (MND) clinic from January 2001 to December 2010. Death certificate information was reviewed to determine race of Arkansans who died of ALS/MND between 1999 and 2006. We used a retrospective chart review of patients with ALS/MND seen at least once in our clinic and reviewed state death certificate data. Results showed that from 1999 to 2006, 466 Arkansas deaths were attributed (immediate or contributory) to ALS/MND; 17 (3.6%) were black, four (0.9%) other, and 445 (95.5%) white. During this period, the proportion of black Arkansans was 17%. From 2001 to 2010, we saw 330 patients with ALS/MND: 30 (9.1%) black, six (1.8%) other, 294 (89.1%) white. Average onset age for whites was 58.1 + 12.4 years, for blacks 52.8 + 13.0 (p = 0.038). Gender, onset site, time from symptom onset to first clinic visit and initial vital capacity were similar between the groups. Initial ALSFRS-R was 37.5 + 7.2 for whites and 30.8 + 8.5 (p = 0.004) for blacks. A first or second degree relative with ALS/MND was reported by 8.1% of whites and by none of the black patients (p = 0.15). Riluzole, PEG and non-invasive ventilation use was similar between the groups. Median tracheostomy-free survival was 36 months for white and 40 months for black patients (p = 0.475). In conclusion, although blacks appear relatively spared from ALS/MND, they present at an earlier age and are functionally worse at their first visit. Investigating the genetic make-up of blacks with the disease may help identify genes that modify risk of developing ALS/MND.

  7. Racial differences in motor neuron disease

    Science.gov (United States)

    GUNDOGDU, BETUL; AL-LAHHAM, TAWFIQ; SPENCER, HORACE; RUDNICKI, STACY A.

    2014-01-01

    Our objective was to compare and contrast clinical features of black and white patients seen in the UAMS ALS/Motor Neuron Disease (MND) clinic from January 2001 to December 2010. Death certificate information was reviewed to determine race of Arkansans who died of ALS/MND between 1999 and 2006. We used a retrospective chart review of patients with ALS/MND seen at least once in our clinic and reviewed state death certificate data. Results showed that from 1999 to 2006, 466 Arkansas deaths were attributed (immediate or contributory) to ALS/MND; 17 (3.6%) were black, four (0.9%) other, and 445 (95.5%) white. During this period, the proportion of black Arkansans was 17%. From 2001 to 2010, we saw 330 patients with ALS/MND: 30 (9.1%) black, six (1.8%) other, 294 (89.1%) white. Average onset age for whites was 58.1 ± 12.4 years, for blacks 52.8 ± 13.0 (p = 0.038). Gender, onset site, time from symptom onset to first clinic visit and initial vital capacity were similar between the groups. Initial ALSFRS-R was 37.5 ± 7.2 for whites and 30.8 ± 8.5 (p = 0.004) for blacks. A first or second degree relative with ALS/MND was reported by 8.1% of whites and by none of the black patients (p = 0.15). Riluzole, PEG and non-invasive ventilation use was similar between the groups. Median tracheostomy-free survival was 36 months for white and 40 months for black patients (p = 0.475). In conclusion, although blacks appear relatively spared from ALS/MND, they present at an earlier age and are functionally worse at their first visit. Investigating the genetic make-up of blacks with the disease may help identify genes that modify risk of developing ALS/MND. PMID:24067242

  8. Katrin Kuldma - obladatelnitsa "Zolotoi iglõ" / Olga Grigorjeva

    Index Scriptorium Estoniae

    Grigorjeva, Olga, 1983-

    2007-01-01

    FIBIT-i moepäevadest ja Kuldnõela galast. Kuldnõela nominendid olid Reet Aus, Katrin Kuldma, Marika Siska ja Tiiu Roosma. 2006. a. moepreemia "Kuldnõel" sai kollektsiooni "Chocolat" eest Katrin Kuldma

  9. Trepp = Stair / Eve Arpo

    Index Scriptorium Estoniae

    Arpo, Eve

    2006-01-01

    Rakvere Vallimäe trepist. Laste vestlus trepil. Projekt: Kavakava. Autorid: Heidi Urb, Siiri Vallner. Trepi valem: Taavi Vallner. Insener: Marika Stokkeby. Projekt 2004, valmis 2005. Ill.: joonis, 7 värv. fotot

  10. Üleujutus arendaja hingel / Maris Kuuda

    Index Scriptorium Estoniae

    Kuuda, Maris

    2007-01-01

    Kohalikel omavalitsustel pole piisavalt hoobasid sundida arendajaid üleujutusohuga arvestama. Pärnusse hotelli September rajajad (arhitektid Emil Urbel, Andrus Mark) arvestavad ujutusohuga. Arvamust avaldavad Rene Reisner, Mari Sepp, Ülo Sults, Karri Tiigisoon, Indrek Rannik, Mark Soosaar, Tiiu Pärn, Merle Looring, Rita Sepp, Kaspar Alles. Keskkonnaministeeriumi plaanist muuta veeseadust, mis sunniks ehitajaid ja arendajaid arvestama üleujutusohuga. Lisadena olulise üleujutusohuga alad Eestis ning üleujutuste ohjamist käsitleva Euroopa Liidu direktiivi eelnõust

  11. A Temporal Association between Accumulated Petrol (Gasoline Lead Emissions and Motor Neuron Disease in Australia

    Directory of Open Access Journals (Sweden)

    Mark A. S. Laidlaw

    2015-12-01

    Full Text Available Background: The age standardised death rate from motor neuron disease (MND has increased from 1.29 to 2.74 per 100,000, an increase of 112.4% between 1959 and 2013. It is clear that genetics could not have played a causal role in the increased rate of MND deaths over such a short time span. We postulate that environmental factors are responsible for this rate increase. We focus on lead additives in Australian petrol as a possible contributing environmental factor. Methods: The associations between historical petrol lead emissions and MND death trends in Australia between 1962 and 2013 were examined using linear regressions. Results: Regression results indicate best fit correlations between a 20 year lag of petrol lead emissions and age-standardised female death rate (R2 = 0.86, p = 4.88 × 10−23, male age standardised death rate (R2 = 0.86, p = 9.4 × 10−23 and percent all cause death attributed to MND (R2 = 0.98, p = 2.6 × 10−44. Conclusion: Legacy petrol lead emissions are associated with increased MND death trends in Australia. Further examination of the 20 year lag between exposure to petrol lead and the onset of MND is warranted.

  12. [Removal Kinetics and Mechanism of Aniline by Manganese-oxide-modified Diatomite].

    Science.gov (United States)

    Xiao, Shao-dan; Liu, Lu; Jiang, Li-ying; Chen, Jian-meng

    2015-06-01

    A novel rapid green one-step method was developed for the preparation of manganese modified diatomite (Mn-D) by treating roasted diatomite with an acidic permanganate solution. The effects of calcination temperature and mass ratio of KMnO4 and diatomite (p) on aniline removal efficiency of Mn-D were investigated. The removal kinetics and mechanism of aniline by Mn-D were also discussed. The results showed that when the optimal calcination temperature was 450 degrees C, p was 1.6, and the loading amounts of δ-MnO2 was 0.82 g x g(-1), Mn-D had a great performance for aniline removal, and more than 80% of aniline was adsorbed within 10 minutes, accompanied with the release of Mn2+. In acidic conditions, the adsorption process on Mn-D followed pseudo-second-order and was mainly controlled by intra-particle diffusion. The best fitting of the experimental adsorption data was given by the Freundlich equation. Gas chromatograph-mass spectrometer was applied to identify the reaction intermediates at different times, and azobenzene was found to be the main reaction intermediate in the degradation system. Based on the above observations, the possible degradation pathway of aniline by Mn-D was proposed.

  13. Kirev moepilt / Britt Rosen

    Index Scriptorium Estoniae

    Rosen, Britt, 1968-

    2007-01-01

    FIBITi moepäevadest Tallinnas Viru keskuses, stilistid Gerli Tinn, Liisi Eesmaa, Kirill Safonov. Kuldnõela auhinna pälvis Katrin Kuldma kollektsiooni Chocolat eest. Oma loomingut esitlesid Reet Aus, Tiiu Roosma, Marika Siska

  14. Raamatututvustus

    Index Scriptorium Estoniae

    2008-01-01

    2007. a. Tallinnas kirjastuselt Varrak ilmunud raamatust "1001 maali, mida elu jooksul peab nägema" (peatoimetaja Stephen Farthing, eessõna Geoff Dyer, tõlkinud Ann Kitsnik, Marika Liivamägi ja Maarja Merivoo)

  15. Alushariduse kvaliteet rahvusvahelises arutelus / Tiia Õun

    Index Scriptorium Estoniae

    Õun, Tiia

    2013-01-01

    Rahvusvahelisest EECERA 23. konverentsist, mis ühendab Euroopa alushariduse uurijaid, juhte, õpetajaid ja üliõpilasi. Konverents toimus 28.-31. aug. Tallinna Ülikoolis, Eesti-poolne peakorraldaja oli Tallinna Ülikooli professor Marika Veisson

  16. Teaduse õpetamine kui missioon

    Index Scriptorium Estoniae

    2010-01-01

    Marika Mikelsaar pälvis teaduse elutöö preemia, millest osa kavatseb kasutada omanimelise fondi loomiseks noorte teadlaste jaoks. Hiljuti valiti ta ülemaailmse ühingu Society for Microbial Ecology and Disease (SOMED) presidendiks

  17. Tallinna võim on libastumine?

    Index Scriptorium Estoniae

    2005-01-01

    Elmar Sepp ja Tõnis Palts vastavad küsimusele, mis puudutab Taavi Veskimäe väidet, et Res Publica koostöö Tallinnas on Res Publica suurima poliitilise libastumise tagajärg. Elmar Sepp ei välista sügisestel valimistel Keskerakonna ja Res Publica koostöö jätkumist Tallinnas, tema sõnul ei ole Keskerakond mitte totalitaarne, vaid Eesti üks demokraatlikumaid erakondi. Vt. samas: Katkend Taavi Veskimäe kõnest Res Publica üldkogul

  18. Eesti Energia : investeerimata oleme varsti hädas / Krista Taim, Allar Viivik

    Index Scriptorium Estoniae

    Taim, Krista

    2004-01-01

    Eesti Energia nõukogu kinnitas ettevõtte investeeringutekava aastani 2018, 15 aasta jooksul tuleb investeerida 46 miljardit krooni, rahastamisallikatena nähakse välislaenu, riigi abi või hinnatõusu. Kommenteerivad Eiki Nestor ja Marika Tuus

  19. Häbi, professor, teil on Gefilus kapis / Eve Kruuse

    Index Scriptorium Estoniae

    Kruuse, Eve,d1959-

    2008-01-01

    Tartu Ülikooli professor Marika Mikelsaar võitis läinud kuul koos kolleegidega (Tiiu Kullisaar, Epp Songisepp, Hedi Annuk ja Mihkel Zilmer) Soulis ülemaailmse naisleiutajate konkursil ME-3 bakteri avastamise ja probiootikuks arendamise eest kuldmedali

  20. Aesthetics of amalgamation / Francisco Martinez

    Index Scriptorium Estoniae

    Martínez, Francisco, 1982-

    2016-01-01

    Parandamise esteetika kontseptsioonist näituste „Ehitamata. Visioonid uuest ühiskonnast 1986–1994“ Eesti Arhitektuurimuuseumis (kuraator Ingrid Ruudi) ja “Parandamise esteetika tänapäeva Gruusias” (kuraator Marika Agu) Tartu Kunstimuuseum valgusel

  1. Feasibility, acceptability, and potential effectiveness of dignity therapy for people with motor neurone disease.

    Directory of Open Access Journals (Sweden)

    Brenda Bentley

    Full Text Available BACKGROUND: Motor neurone disease (MND practice guidelines suggest developing interventions that will promote hope, meaning, and dignity to alleviate psychological distress, but very little research has been done. This study begins to address this need by exploring the use of dignity therapy with people with MND. Dignity therapy is a brief psychotherapy that promotes hope, meaning and dignity, and enhances the end of life for people with advanced cancer. The aims of this study are to assess the feasibility, acceptability, and potential effectiveness of dignity therapy for people with MND. METHODS/DESIGN: This cross-sectional feasibility study used a one-group pre-test post-test design with 29 people diagnosed with MND. Study participants completed the following self-report questionnaires: Herth Hope Index, FACIT-sp, Patient Dignity Inventory, ALS Assessment Questionnaire, ALS Cognitive Behavioural Screen, and a demographic and health history questionnaire. Acceptability was measured with a 25-item feedback questionnaire. Feasibility was assessed by examining the length of time taken to complete dignity therapy and how symptoms common in MND affected the intervention. Generalised linear mixed models and reliable change scores were used to analyse the data. RESULTS: There were no significant pre-test post-test changes for hopefulness, spirituality or dignity on the group level, but there were changes in hopefulness on the individual level. The results of the feedback questionnaire indicates dignity therapy is highly acceptable to people with MND, who report benefits similar to those in the international randomised controlled trial on dignity therapy, a population who primarily had end-stage cancer. Benefits include better family relationships, improved sense of self and greater acceptance. Dignity therapy with people with MND is feasible if the therapist can overcome time and communication difficulties. CONCLUSIONS: Dignity therapy for people with

  2. Valmib valus lavalugu perest : Athenas jõuab vaatajate ette Mart Kivastiku suhtedraama / Raimu Hanson

    Index Scriptorium Estoniae

    Hanson, Raimu, 1957-

    2008-01-01

    SA Eesti Teatri Festival esietendab 4. mail Athena keskuses Margus Kasterpalu lavastuses Mart Kivastiku näidendit "Meie isa, kes sa oled ..." Mängivad Vanemuise näitlejad Marika Aidla, Hannes Kaljujärv, Tanel Jonas ning Leino Rei

  3. Räägi nii, et pisarad voolaksid! Kuidas saab inimesi oma lugude abil juhtida / Taivo Paju

    Index Scriptorium Estoniae

    Paju, Taivo, 1968-

    2011-01-01

    Kuulajat puudutavate lugude rääkimine. Kuidas toimub lugude loomine inimese ajus. Termin "corporate storytelling". Noppeid Pärnu turunduskonverentsi firmalugude võisturääkimiselt, kus jutustasid Ants Lusti, Marika Pärn, Piret Järvan ja Matts Heijbel

  4. Poolsajandi õnnesoovid Jaak Aaviksoole / Ain Heinaru, Jaak Kangilaski, Tõnu Lehtsaar...[jt.

    Index Scriptorium Estoniae

    2004-01-01

    Mõtteid Tartu Ülikooli rektorist tema 50. sünnipäeva puhul : Ain Heinaru, Jaak Kangilaski, Tõnu Lehtsaar, Indrek Reimand, Toomas Kiho, Leelo Kriisa, Peeter Olesk, Risto Tammelo, Birute Klaas, Peeter Saari, Andrus Ansip, Mait Klaassen, Marika Kullamaa, Kaupo Bend

  5. 8. III esitleti Adamson-Ericu muuseumis ajakirja Muuseum 2005. aasta esimest numbrit

    Index Scriptorium Estoniae

    2005-01-01

    Tomislav Shola kirjutab "Kvaliteedist pärimusinstitutsioonides". Rahvusvaheliste konverentside kogemusi jagavad Toomas Abiline, Aino Lepp, Lea Sillart ja Karin Hallas-Murula. Eesti muuseumide olulistest tähtpäevadest kirjutavad Urmas Dresen, Mari-Ann Aimla, Marika Valk ja Merike Koppel

  6. Kuidas töötab teie kooli tugisüsteem? / Maria Tiro, Siiri Klasberg, Maarika Kongi ... [jt.

    Index Scriptorium Estoniae

    2011-01-01

    Küsimusele vastasid Jüri gümnaasiumi direktor Maria Tiro, Tapa gümnaasiumi sotsiaalpedagoog Siiri Klasberg, Rakvere gümnaasiumi psühholoog Maarika Kongi, Kuressaare gümnaasiumi sotsiaalpedagoog Maret Martinson, Salme põhikooli direktor Marika Pütsep

  7. Riik reklaamib Tallinna napsi ja naistega / Kadri Jakobson

    Index Scriptorium Estoniae

    Jakobson, Kadri, 1970-

    2005-01-01

    Ettevõtluse Arendamise Sihtasutuse makstud reklaamikampaania, mis valmis reklaamifirmas Brilliant Marketing Communication OÜ, kutsus turismiarendajates esile meelepaha. EAS Turismiarenduskeskuse direktori Marika Liivamäe hinnangul olid mõned kaadrid liiga julged ja ekstreemsed. Reklaamikampaania oli mõeldud Eesti tutvustamiseks Põhjamaa noortele

  8. Kuldma, Aus, Roosma ja Siska

    Index Scriptorium Estoniae

    2007-01-01

    2006. aasta Kuldnõela võitja kuulutatakse välja Tallinnas Viru keskuses 9.03.2007. Kandidaadid Katrin Kuldma kollektsiooniga Chocolate, Reet Aus kaubamärgiga Re Use, Tiiu Roosma pesukollektsiooniga BonBon Lingerie ja Marika Siska kaubamärgiga Sangar

  9. Mamma Bakteri musketärid / Kati Murutar

    Index Scriptorium Estoniae

    Murutar, Kati, 1967-

    2006-01-01

    Tartu Ülikooli teadlase, 2004. Aasta Naiseks nimetatud meditsiinilise biotehnoloogia erakorralise professorr Marika Mikelsaare juhitav töörühm avastas ja tõi maailmakaardile probiootilise piimhappebaketri Lactobacillus fermentum ME-3, mis toimib tervistavalt, hävitades kahjulikke mikroobe

  10. Scheteligi büroo- ja laohoone = Schetelig's Office Building and Warehouse / Epp Lankots

    Index Scriptorium Estoniae

    Lankots, Epp, 1976-

    2000-01-01

    Kahekorruseline, minimalistliku kastja mahuga hoone. Peafassaadi kujunduses on kasutatud firma nime. Projekteerija Arhitektibüroo J. Okas & M. Lõoke. Arhitektid Jüri Okas, Marika Lõoke. Sisekujundaja Kristiina Voolaid. Projekt 1998, valmis 2000. 7 ill. Korruste plaanid, lõige, välisvaated

  11. Delta Plaza kohvik = The Delta Plaza Café / Margit Mutso

    Index Scriptorium Estoniae

    Mutso, Margit, 1966-

    2010-01-01

    Tallinnas Pärnu mnt. 141 asuva kohviku Delta Plaza sisekujundusest. Sisearhitektid Tiiu Truus ja Marja Viltrop (Stuudio Truus OÜ). Hoone arhitektid Jüri Okas ja Marika Lõoke (AB J. Okas & M. Lõoke). Žürii liikme Mait Summataveti arvamus kohvikust

  12. Hiigelämblik kanali kohal ehk Kuidas ERMi uus hoone lõi kired lõkkele / Tarmo Michelson

    Index Scriptorium Estoniae

    Michelson, Tarmo, 1975-

    2006-01-01

    Eesti Rahva muuseumi uue hoone arhitektuurikonkursi võidutööst "Memory Field" (autorid itaalia arhitekt Dan Dorell, liibanoni arhitekt Lina Ghotmeh, jaapani arhitekt Tsuyoshi Tane). Kommenteerivad Jaanus Plaat, Tõnis Lukas, Karin Hallas-Murula, Raivo Palmaru, Laine Jänes, Marika Valk

  13. The Effectiveness of Prophylactic Modified Neck Dissection for Reducing the Development of Lymph Node Recurrence of Papillary Thyroid Carcinoma.

    Science.gov (United States)

    Ito, Yasuhiro; Miyauchi, Akira; Kudo, Takumi; Kihara, Minoru; Fukushima, Mitsuhiro; Miya, Akihiro

    2017-09-01

    The most frequent recurrence site of papillary thyroid carcinoma (PTC) is the cervical lymph nodes. The introduction of an electric linear probe for use with ultrasonography in 1996 improved preoperative lateral neck evaluations. Before 2006, however, our hospital routinely performed prophylactic modified neck dissection (p-MND) for N0 or N1a PTCs >1 cm to prevent node recurrence. In 2006, we changed our policy and the indications for p-MND to PTCs >3 cm and/or with significant extrathyroid extension. Here, we retrospectively compared lymph node recurrence-free survival between PTCs with/without p-MND. We examined the cases of N0 or N1 and M0 PTC patients who underwent initial surgery in 1992-2012. To compare lymph node recurrence-free survival between patients who did/did not undergo p-MND, we divided these patients into three groups (excluding those whose surgery was in 2006): the 2045 patients whose surgery was performed in 1992-1996 (Group 1), the 2989 with surgery between 1997 (post-introduction of ultrasound electric linear probes) and 2005 (Group 2), and the 5332 operated on in 2007-2012 (Group 3). The p-MND performance rate of Group 3 (9%) was much lower than that of Group 1 (80%), but the lymph node recurrence-free survival of the former was significantly better, probably due to differences in clinical features and neck evaluations by ultrasound between the two groups. Our analysis of the patients aged Abolishing routine p-MND for PTCs in 2006 did not decrease lymph node recurrence-free survival, probably due to improved ultrasound preoperative neck evaluations and clinical feature changes. Selective p-MND for high-risk cases improved lymph node recurrence-free survival.

  14. The TiM system: developing a novel telehealth service to improve access to specialist care in motor neurone disease using user-centered design.

    Science.gov (United States)

    Hobson, Esther V; Baird, Wendy O; Partridge, Rebecca; Cooper, Cindy L; Mawson, Susan; Quinn, Ann; Shaw, Pamela J; Walsh, Theresa; Wolstenholme, Daniel; Mcdermott, Christopher J

    2018-08-01

    Attendance at a specialist multidisciplinary motor neurone disease (MND) clinic is associated with improved survival and may also improve quality of life and reduce hospital admissions. However, patients struggle to travel to clinic and may experience difficulties between clinic visits that may not be addressed in a timely manner. We wanted to explore how we could improve access to specialist MND care. We adopted an iterative, user-centered co-design approach, collaborating with those with experience of providing and receiving MND care including patients, carers, clinicians, and technology developers. We explored the unmet needs of those living with MND, how they might be met through service redesign and through the use of digital technologies. We developed a new digital solution and performed initial testing with potential users including clinicians, patients, and carers. We used these findings to develop a telehealth system (TiM) using an Android app into which patients and carers answer a series of questions about their condition on a weekly basis. The questions aim to capture all the physical, emotional, and social difficulties associated with MND. This information is immediately uploaded to the internet for review by the MND team. The data undergoes analysis in order to alert clinicians to any changes in a patient or carer's condition. We describe the benefits of developing a novel digitally enabled service underpinned by participatory design. Future trials must evaluate the feasibility and acceptability of the TiM system within a clinical environment.

  15. Myonuclear domain size and myosin isoform expression in muscle fibres from mammals representing a 100,000-fold difference in body size.

    Science.gov (United States)

    Liu, Jing-Xia; Höglund, Anna-Stina; Karlsson, Patrick; Lindblad, Joakim; Qaisar, Rizwan; Aare, Sudhakar; Bengtsson, Ewert; Larsson, Lars

    2009-01-01

    This comparative study of myonuclear domain (MND) size in mammalian species representing a 100,000-fold difference in body mass, ranging from 25 g to 2500 kg, was undertaken to improve our understanding of myonuclear organization in skeletal muscle fibres. Myonuclear domain size was calculated from three-dimensional reconstructions in a total of 235 single muscle fibre segments at a fixed sarcomere length. Irrespective of species, the largest MND size was observed in muscle fibres expressing fast myosin heavy chain (MyHC) isoforms, but in the two smallest mammalian species studied (mouse and rat), MND size was not larger in the fast-twitch fibres expressing the IIA MyHC isofom than in the slow-twitch type I fibres. In the larger mammals, the type I fibres always had the smallest average MND size, but contrary to mouse and rat muscles, type IIA fibres had lower mitochondrial enzyme activities than type I fibres. Myonuclear domain size was highly dependent on body mass in the two muscle fibre types expressed in all species, i.e. types I and IIA. Myonuclear domain size increased in muscle fibres expressing both the beta/slow (type I; r = 0.84, P fast IIA MyHC isoform (r = 0.90; P muscle fibre type, independent of species. However, myosin isoform expression is not the sole protein determining MND size, and other protein systems, such as mitochondrial proteins, may be equally or more important determinants of MND size.

  16. Exploring the Role of PGC-1α in Defining Nuclear Organisation in Skeletal Muscle Fibres.

    Science.gov (United States)

    Ross, Jacob A; Pearson, Adam; Levy, Yotam; Cardel, Bettina; Handschin, Christoph; Ochala, Julien

    2017-06-01

    Muscle fibres are multinucleated cells, with each nucleus controlling the protein synthesis in a finite volume of cytoplasm termed the myonuclear domain (MND). What determines MND size remains unclear. In the present study, we aimed to test the hypothesis that the level of expression of the transcriptional coactivator PGC-1α and subsequent activation of the mitochondrial biogenesis are major contributors. Hence, we used two transgenic mouse models with varying expression of PGC-1α in skeletal muscles. We isolated myofibres from the fast twitch extensor digitorum longus (EDL) and slow twitch diaphragm muscles. We then membrane-permeabilised them and analysed the 3D spatial arrangements of myonuclei. In EDL muscles, when PGC-1α is over-expressed, MND volume decreases; whereas, when PGC-1α is lacking, no change occurs. In the diaphragm, no clear difference was noted. This indicates that PGC-1α and the related mitochondrial biogenesis programme are determinants of MND size. PGC-1α may facilitate the addition of new myonuclei in order to reach MND volumes that can support an increased mitochondrial density. J. Cell. Physiol. 232: 1270-1274, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  17. Sorption of Cr(III) ion from aqueous solution by two kinds of modified diatomite.

    Science.gov (United States)

    Li, Er; Zeng, Xiangying

    2012-01-01

    Raw diatomite modified by microemulsion (DMM) and manganese oxide (MnD) were used for the removal of Cr(III) ions from aqueous solution. The characteristics and performance of these two types of modified diatomite on Cr(III) ion adsorption were compared. The results indicate that the Cr(III) ion adsorption capacities of diatomite were considerably improved after modifications by manganese oxide (MnO) and microemulsion. The surface area of MnD was increased because of the formation of MnO on the diatomite surface, and that of DMM was promoted owing to the existence of the hydrolyzed aromatic acid. Because of the stronger surface ionized function, the adsorption performance of Cr(III) ions in DMM was better than that in MnD. Within the experimental range of pH (i.e. 2.2-6.3), the Cr(III) ion removal of DMM (35-70%) was higher than that of MnD (33-59%) owing to the different electrostatic forces between the Cr(III) ion and the surface of the modified diatomite. The Cr(III) ion removal in MnD and DMM was improved with the increase of synthetic solution concentration in volumes from 0 to 2,500 mL.

  18. Plasma Selenium Biomarkers in Low Income Black and White Americans from the Southeastern United States

    Science.gov (United States)

    Hargreaves, Margaret K.; Liu, Jianguo; Buchowski, Maciej S.; Patel, Kushal A.; Larson, Celia O.; Schlundt, David G.; Kenerson, Donna M.; Hill, Kristina E.; Burk, Raymond F.; Blot, William J.

    2014-01-01

    Biomarkers of selenium are necessary for assessing selenium status in humans, since soil variation hinders estimation of selenium intake from foods. In this study, we measured the concentration of plasma selenium, selenoprotein P (SEPP1), and glutathione peroxidase (GPX3) activity and their interindividual differences in 383 low-income blacks and whites selected from a stratified random sample of adults aged 40–79 years, who were participating in a long-term cohort study in the southeastern United States (US). We assessed the utility of these biomarkers to determine differences in selenium status and their association with demographic, socio-economic, dietary, and other indicators. Dietary selenium intake was assessed using a validated food frequency questionnaire designed for the cohort, matched with region-specific food selenium content, and compared with the US Recommended Dietary Allowances (RDA) set at 55 µg/day. We found that SEPP1, a sensitive biomarker of selenium nutritional status, was significantly lower among blacks than whites (mean 4.4±1.1 vs. 4.7±1.0 mg/L, p = 0.006), with blacks less than half as likely to have highest vs. lowest quartile SEPP1 concentration (Odds Ratio (OR) 0.4, 95% Confidence Interval (CI) 0.2–0.8). The trend in a similar direction was observed for plasma selenium among blacks and whites, (mean 115±15.1 vs. 118±17.7 µg/L, p = 0.08), while GPX3 activity did not differ between blacks and whites (136±33.3 vs. 132±33.5 U/L, p = 0.320). Levels of the three biomarkers were not correlated with estimated dietary selenium intake, except for SEPP1 among 10% of participants with the lowest selenium intake (≤57 µg/day). The findings suggest that SEPP1 may be an effective biomarker of selenium status and disease risk in adults and that low selenium status may disproportionately affect black and white cohort participants. PMID:24465457

  19. TDP-43 pathology in familial frontotemporal dementia and motor neuron disease without Progranulin mutations.

    NARCIS (Netherlands)

    Seelaar, H.; Schelhaas, H.J.; Azmani, A.; Kusters, B.; Rosso, S.; Majoor-Krakauer, D.F.; Rijik, M.C. de; Rizzu, P.; Brummelhuis, M. Ten; Doorn, P.A. van; Kamphorst, W.; Willemsen, R.; Swieten, J. van

    2007-01-01

    Frontotemporal dementia is accompanied by motor neuron disease (FTD + MND) in approximately 10% of cases. There is accumulating evidence for a clinicopathological overlap between FTD and MND based on observations of familial aggregation and neuropathological findings of ubiquitin-positive neuronal

  20. TDP-43 pathology in familial frontotemporal dementia and motor neuron disease without Progranulin mutations

    NARCIS (Netherlands)

    H. Seelaar (Harro); H. Jurgen Schelhaas; A. Azmani (Asma); B. Küsters (Benno); S.M. Rosso (Sonia); D.F. Majoor-Krakauer (Danielle); M.C. de Rijik (Maarten); P. Rizzu (Patrizia); M. ten Brummelhuis (Ming); P.A. van Doorn (Pieter); W. Kamphorst (Wouter); R. Willemsen (Rob); J.C. van Swieten (John)

    2007-01-01

    textabstractFrontotemporal dementia is accompanied by motor neuron disease (FTD + MND) in ∼10% of cases. There is accumulating evidence for a clinicopathological overlap between FTD and MND based on observations of familial aggregation and neuropathological findings of ubiquitin-positive neuronal

  1. Teenetemärgid

    Index Scriptorium Estoniae

    2005-01-01

    Tartu Ülikooli kollektiivi liikmetest saavad Eesti vabariigi 87. aastapäeva puhul riikliku autasu külalisprofessorid Stig Erik örjan Ohlsson ja Uno lõhmus, professorid mati Erelt, Volli kalm, kalle merusk, Aadu Must, Paul varul, Jaan Eha, bibliograaf Marika Meltsas

  2. Is dignity therapy feasible to enhance the end of life experience for people with motor neurone disease and their family carers?

    Directory of Open Access Journals (Sweden)

    Bentley Brenda

    2012-09-01

    Full Text Available Abstract Background Development of interventions that address psychosocial and existential distress in people with motor neurone disease (MND or that alleviate caregiver burden in MND family carers have often been suggested in the research literature. Dignity therapy, which was developed to reduce psychosocial and existential distress at the end of life, has been shown to benefit people dying of cancer and their families. These results may not be transferable to people with MND. The objectives of this study are to assess the feasibility, acceptability and potential effectiveness of dignity therapy to enhance the end of life experience for people with motor neurone disease and their family carers. Methods/design This is a cross-sectional study utilizing a single treatment group and a pre/post test design. The study population will comprise fifty people diagnosed with MND and their nominated family carers. Primarily quantitative outcomes will be gathered through measures assessed at baseline and at approximately one week after the intervention. Outcomes for participants include hopefulness, spirituality and dignity. Outcomes for family carers include perceived caregiver burden, hopefulness and anxiety/depression. Feedback and satisfaction with the intervention will be gathered through a questionnaire. Discussion This detailed research will explore if dignity therapy has the potential to enhance the end of life experience for people with MND and their family carers, and fill a gap for professionals who are called on to address the spiritual, existential and psychosocial needs of their MND patients and families. Trial registration ACTRN Trial Number: ACTRN12611000410954

  3. Comparison of Performance of the VIP and WMT in a Criminal Forensic Sample.

    Science.gov (United States)

    Fazio, Rachel L; Denney, Robert L

    2018-01-24

    To compare the efficacy of the Validity Indicator Profile (VIP) and Word Memory Test (WMT) in a criminal forensic population. Potential participants included 225 male evaluees from a maximum-security Federal prison referred for neuropsychological evaluation for either forensic purposes or for suspected neurocognitive dysfunction as part of a medical evaluation. Examinees were included in the analysis if administered the VIP (Verbal, Nonverbal, or both tests) and WMT along with at least two other freestanding PVTs; 74 satisfied these criteria. Participants were then categorized as having probable Malingered Neurocognitive Dysfunction (+MND) if they failed at least two freestanding validity indicators, negative for MND (-MND) if they passed all indicators, and Possible MND (pMND) if they failed one indicator. Groups were very demographically similar. There were significant differences in WMT scores and distribution of VIP profiles across groups. Whether using traditional or investigative cut scores, and whether using the WMT with or without consideration of a GMIP profile, the WMT demonstrated superior sensitivity and specificity on nearly every comparison. The VIP, when interpreted in the traditional fashion, and the WMT with GMIP, both had more than adequate psychometric properties when used with criminal forensic evaluees, strengthening the body of literature supporting their use for these types of evaluations. Counting a positive on either of the VIP subtests as an indication of +MND improves the psychometric properties of the VIP slightly, although the WMT had the better overall classification accuracy. © The Author(s) 2018. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  4. Decision-making and referral processes for patients with motor neurone disease: a qualitative study of GP experiences and evaluation of a new decision-support tool.

    Science.gov (United States)

    Baxter, Susan; McDermott, Christopher J

    2017-05-08

    The diagnosis of motor neurone disease (MND) is known to be challenging and there may be delay in patients receiving a correct diagnosis. This study investigated the referral process for patients who had been diagnosed with MND, and whether a newly-developed tool (The Red Flags checklist) might help General Practitioners (GPs) in making referral decisions. We carried out interviews with GPs who had recently referred a patient diagnosed with MND, and interviews/surveys with GPs who had not recently referred a patient with suspected MND. We collected data before the Red Flags checklist was introduced; and again one year later. We analysed the data to identify key recurring themes. Forty two GPs took part in the study. The presence of fasciculation was the clinical feature that most commonly led to consideration of a potential MND diagnosis. GPs perceived that their role was to make onward referrals rather than attempting to make a diagnosis, and delays in correct diagnosis tended to occur at the specialist level. A quarter of participants had some awareness of the newly-developed tool; most considered it useful, if incorporated into existing systems. While fasciculation is the most common symptom associated with MND, other bulbar, limb or respiratory features, together with progression should be considered. There is a need for further research into how decision-support tools should be designed and provided, in order to best assist GPs with referral decisions. There is also a need for further work at the level of secondary care, in order that referrals made are re-directed appropriately.

  5. Lahkus juhmi Hundi ja kavala Jänese looja / Andri Maimets, Marko Lillemägi

    Index Scriptorium Estoniae

    Maimets, Andri, 1979-

    2006-01-01

    Suri vene animakunstnik, kuulsate tegelaskujude - Hundi ja Jänese looja joonisfilmisarjas (1969-1986) "Oota sa!" ("Nu, pogodi!") Svetozar Russakov (sünd. 3.04.1923). Filmi omaaegset mõju meenutab Rein Raamat. Kommenteerivad Raivo Järvi, Hendrik Normann, Ain Nurmela, Marika Korolev, Evelin Samuel

  6. Naisleiutajad said suure tunnustuse

    Index Scriptorium Estoniae

    2008-01-01

    Ehtekunstnik Kärt Summatavet pälvis Soulis toimunud ülemaailmsel naisleiutajate konkursil hõbemedali metallehete valmistamise uudse meetodi eest. Marika Mikelsaar koos töörühmaga Lactobacillus fermentum ME-3 bakterit sisaldava piimatoodete sarja väljatöötamise eest

  7. Eurohindu tuleb näidata enne kursi selgumist / Väinu Rozental

    Index Scriptorium Estoniae

    Rozental, Väinu, 1957-

    2010-01-01

    1. juulist tuleb avaldada kaupade ja teenuste hinnad nii kroonides kui ka eurodes. Arvamust avaldavad Eesti Kaupmeeste Liidu tegevdirektor Marika Merilai, ASi Rimi Eesti Food turundusjuht Evelin Mägioja ja OÜ Maxima Eesti brändi ja kommunikatsiooni osakonna direktor Ty Lehtmäe

  8. Delta Plaza kohvik = Delta Plaza cafe

    Index Scriptorium Estoniae

    2010-01-01

    Tallinnas Pärnu mnt 141 asuva kohviku Delta Plaza sisekujundusest. Sisearhitektid Tiiu Truus ja Marja Viltrop (Stuudio Truus OÜ). Tiiu Truusi tähtsamate tööde loetelu. Büroohoone Delta Plaza arhitektid Marika Lõoke ja Jüri Okas (AB J. Okas & M. Lõoke)

  9. Record linkage between hospital discharges and mortality registries for motor neuron disease case ascertainment for the Spanish National Rare Diseases Registry.

    Science.gov (United States)

    Ruiz, Elena; Ramalle-Gómara, Enrique; Quiñones, Carmen

    2014-06-01

    Our objective was to analyse the coverage of hospital discharge data and the mortality registry (MR) of La Rioja to ascertain motor neuron disease (MND) cases to be included in the Spanish National Rare Diseases Registry. MND cases that occurred in La Rioja during the period 1996-2011 were selected from hospital discharge data and the MR by means of the International Classification of Diseases. Review of the medical histories was carried out to confirm the causes of death reported. Characteristics of the population with MND were analysed. A total of 133 patients with MND were detected in La Rioja during the period 1996-2011; 30.1% were only recorded in the hospital discharges data, 12.0% only in the MR, and 57.9% were recorded by both databases. Medical records revealed a miscoding of patients who had been diagnosed with progressive supranuclear palsy but were recorded in the MR with an MND code. In conclusion, the hospital discharges data and the MR appear to be complementary and are valuable databases for the Spanish National Rare Diseases Registry when MNDs are properly codified. Nevertheless, it would be advisable to corroborate the validity of the MR as data source since the miscoding of progressive supranuclear palsy has been corrected.

  10. Being Yourself and Thinking About the Future in People With Motor Neuron Disease: A Grounded Theory of Self-care Processes.

    Science.gov (United States)

    Bassola, Barbara; Sansone, Valeria Ada; Lusignani, Maura

    2018-06-01

    Self-care is a crucial aspect in the management of people with motor neuron disease (MND). Nurses and healthcare professionals must know the processes used by patients in performing self-care to identify problems and help them. Decision-making processes, self-understanding, and political and social support influence the self-care process in chronic diseases. Little is known about the self-care process in MND. The aim of this study was to gain insight on the self-care processes in people with MND. A grounded theory method was chosen for this study. Data from interviews were gathered, and a simultaneous comparative analysis was conducted to identify categories and codes. Twenty-one people with spinal muscular atrophy and amyotrophic lateral sclerosis participated in the study. Five categories were identified as grounded in the data. The process starts from "being yourself in the care," and it develops thanks to "growing and changing" and with a "thinking about the future" approach. "Family role" and "you and who helps you" categories affect the process itself. The self-care process in people with MND is not seen in a daily perspective but changes with the evolution of the disease. For the growing patients with MND, changing, accepting and controlling the disease while deciding autonomously are the foundations of the process.

  11. Interactions of Aging, Overload, and Creatine Supplementation in Rat Plantaris Muscle

    Directory of Open Access Journals (Sweden)

    Mark D. Schuenke

    2011-01-01

    Full Text Available Attenuation of age-related sarcopenia by creatine supplementation has been equivocal. In this study, plantaris muscles of young (Y; 5m and aging (A; 24m Fisher 344 rats underwent four weeks of either control (C, creatine supplementation (Cr, surgical overload (O, or overload plus creatine (OCr. Creatine alone had no effect on muscle fiber cross-sectional area (CSA or heat shock protein (HSP70 and increased myonuclear domain (MND only in young rats. Overload increased CSA and HSP70 content in I and IIA fibers, regardless of age, and MND in IIA fibers of YO rats. CSA and MND increased in all fast fibers of YOCr, and CSA increased in I and IIA fibers of AOCr. OCR did not alter HSP70, regardless of age. MND did not change in aging rats, regardless of treatment. These data indicate creatine alone had no significant effect. Creatine with overload produced no additional hypertrophy relative to overload alone and attenuated overload-induced HSP70 expression.

  12. Arhitektuuribüroo Pluss = Pluss Architects

    Index Scriptorium Estoniae

    2009-01-01

    Büroohoones Delta Plaza (Pärnu mnt. 141, Tallinn) asuva AB Pluss ruumide sisekujundusest. Sisearhitektid Argo Vaikla, Katrin Vaikla ja Riin Luuk. Büroohoone arhitektid Jüri Okas ja Marika Lõoke. Kogu mööblikomplekt on erilahendusega. Sisearhitektide tähtsamate tööde loetelu

  13. Estconde büroohoone = Estconde Office Building / Epp Lankots

    Index Scriptorium Estoniae

    Lankots, Epp, 1976-

    2002-01-01

    Tallinnas Toompuiestee 33 asuva hoone rekonstrueerimine. Projekteerija: büroo J. Okas & M. Lõoke. Arhitektid Jüri Okas ja Marika Lõoke. Konstruktiivne osa: Neoprojekt. Ehituse peatöövõtt: Estconde-E. Projekt ja hoone valmisid 2001. 7 ill.: välis- ja sisevaated, II korruse plaan

  14. Projektiivne arhitektuur / Leonhard Lapin

    Index Scriptorium Estoniae

    Lapin, Leonhard, 1947-

    2003-01-01

    Arhitekti loomeprotsess. Arhitekti ja helilooja loomemeetodi sarnasus. Omaruumi mõiste. Projektiivne arhitektuur. Jüri Okase ja Marika Lõokese projektiivne arhitektuur, nende 1996-2002. aastate 22 projekti 40 perspektiivvaadet esikaanel, lk. 1, 11-48. J. Okasele ja M. Lõokesele anti 2002. a. arhitektuuriloomingu eest Eesti Kultuurkapitali aastapreemia

  15. Turistid-sõjaõhutajad : dessant Iisraeli / Karin Hallas

    Index Scriptorium Estoniae

    Hallas, Karin, 1957-

    1999-01-01

    Kultuuridessandist Marika Valgu ja Helle Puusepaga Iisraeli. Jeruusalemma Yad Vashemist ئ Holocausti muuseumist. Arhitekt Moshe Safdie Laste Memoriaali ja Yad Vashemi memoriaali uue hoone lahendusest. Tel Avivi ja Jeruusalemma arhitektuurist ئ funktsionalismist, praegusest arhitektuurist, arhitekte. James Turrelli kunstiteosest "Ruum, mis näeb" Jeruusalemma muuseumi pargis

  16. Männikusse kasvatatud Rannametsa / Risto Kozer

    Index Scriptorium Estoniae

    Kozer, Risto

    2009-01-01

    Rannametsa elamukompleks (2 kortermaja, 4 ridaelamut, 3 eramut) Vääna-Jõesuus endise pioneerilaagri "Energia" alal. Arhitektid: Jüri Okas, Marika Lõoke, AB J. Okas & M. Lõoke. Ehitaja: AS YIT Ehitus. Projekt: 2005, valmis: 2007. Kompleks on valatud betoonist, mille juures on kasutatud puitlaudiseid ja alumiiniumviimistlust

  17. Innovatsioon = Innovation

    Index Scriptorium Estoniae

    2008-01-01

    TÜ teadlased töötavad välja Philipsi tellimusel uut tomograafi; prof. Marika Mikelsaar pälvis bakteri ME-3 kasutamise eest Euroopa Liidu innovaatori auhinna; toruluude murdude fragmentide ühendamiseks koostatud leiutisele said patendi Aleks Lenzner ja Tiit Haviko TÜ-st ning Vladimir Andrianov EMÜ-st

  18. Salme Reegi nimelise auhinna nominendid

    Index Scriptorium Estoniae

    2006-01-01

    Valiti järgmised nominendid : Taago Tubin - lavastus "Suur kuri hunt" Vanemuises, Marika Vaarik - õpetaja Klamm VAT Teatri lavastuses "Klammi sõda", Finn Poulsen - "Trollpoiss" Eesti Nukuteatris, Leino Rei - lavastused "Kuusepuu", "Karjatüdruk ja korstnapühkija", Taavi Tõnisson - Papageno "Võluflöödis" Eesti Nukuteatri lavastuses

  19. Autotranspordi TOP aastal 2007

    Index Scriptorium Estoniae

    2008-01-01

    TOP 50. Vt. samas: Käibe TOP 10; Käibe kasvu TOP 10; Kasumi TOP 10; Kasumi kasvu TOP 10; Rentaabluse TOP 10; Omakapitali tootlikkuse TOP 10; Marika Roomere. Täisteenuse pakkumine kergitas tulemusi; Jupiter Plus otsib järjest uusi kasvuvõimalusi; EST-Trans Kaubaveod teenib kasumit toiduvedamisega

  20. Structural and functional brain signatures of C9orf72 in motor neuron disease.

    Science.gov (United States)

    Agosta, Federica; Ferraro, Pilar M; Riva, Nilo; Spinelli, Edoardo Gioele; Domi, Teuta; Carrera, Paola; Copetti, Massimiliano; Falzone, Yuri; Ferrari, Maurizio; Lunetta, Christian; Comi, Giancarlo; Falini, Andrea; Quattrini, Angelo; Filippi, Massimo

    2017-09-01

    This study investigated structural and functional magnetic resonance imaging abnormalities in hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9orf72) motor neuron disease (MND) relative to disease severity-matched sporadic MND cases. We enrolled 19 C9orf72 and 67 disease severity-matched sporadic MND patients, and 22 controls. Sporadic cases were grouped in patients with: no cognitive/behavioral deficits (sporadic-motor); same patterns of cognitive/behavioral impairment as C9orf72 cases (sporadic-cognitive); shorter disease duration versus other sporadic groups (sporadic-early). C9orf72 patients showed cerebellar and thalamic atrophy versus all sporadic cases. All MND patients showed motor, frontal, and temporoparietal cortical thinning and motor and extramotor white matter damage versus controls, independent of genotype and presence of cognitive impairment. Compared with sporadic-early, C9orf72 patients revealed an occipital cortical thinning. C9orf72 patients had enhanced visual network functional connectivity versus sporadic-motor and sporadic-early cases. Structural cerebellar and thalamic damage and posterior cortical alterations are the brain magnetic resonance imaging signatures of C9orf72 MND. Frontotemporal cortical and widespread white matter involvement are likely to be an effect of the disease evolution rather than a C9orf72 marker. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. Annid merest / Marika Makarova

    Index Scriptorium Estoniae

    Makarova, Marika

    2011-01-01

    Toiduks tarvitatavatest koorikloomadest ja molluskitest: krabi, krevett, garneel, homaar e merivähk, jõe- e väärisvähk, signaal- e tähnikvähk, langust e ogajas merivähk, auster, kammkarp, rannakarp, kaheksajalg, kalmaar, seepia e tindikala, meritigu e tõrikodalane, viinamäe- e burgundia tigu, merisiilik ning kalatootest surimi e makra

  2. Imekliinik Brasiilias / Marika Makarova

    Index Scriptorium Estoniae

    Makarova, Marika

    2010-01-01

    Brasiilia Abadiania väikelinnas asuvast Casa de Dom Inacio tervendamiskeskusest, kus meediumi vahendusel toimuvad meditatsioonid ja "operatsioonid" ning inimesed paranevad lühikese ajaga rasketest haigustest. Seal ravil käinud Eesti naise kogetust

  3. The MY NASA DATA Project: Preparing Future Earth and Environmental Scientists, and Future Citizens

    Science.gov (United States)

    Chambers, L. H.; Phelps, C. S.; Phipps, M.; Holzer, M.; Daugherty, P.; Poling, E.; Vanderlaan, S.; Oots, P. C.; Moore, S. W.; Diones, D. D.

    2008-12-01

    For the past 5 years, the MY NASA DATA (MND) project at NASA Langley has developed and adapted tools and materials aimed at enabling student access to real NASA Earth science satellite data. These include web visualization tools including Google Earth capabilities, but also GPS and graphing calculator exercises, Excel spreadsheet analyses, and more. The project team, NASA scientists, and over 80 classroom science teachers from around the country, have created over 85 lesson plans and science fair project ideas that demonstrate NASA satellite data use in the classroom. With over 150 Earth science parameters to choose from, the MND Live Access Server enables scientific inquiry on numerous interconnected Earth and environmental science topics about the Earth system. Teachers involved in the project report a number of benefits, including networking with other teachers nationwide who emphasize data collection and analysis in the classroom, as well as learning about other NASA resources and programs for educators. They also indicate that the MND website enhances the inquiry process and facilitates the formation of testable questions by students (a task that is typically difficult for students to do). MND makes science come alive for students because it allows them to develop their own questions using the same data scientists use. MND also provides educators with a rich venue for science practice skills, which are often overlooked in traditional curricula as teachers concentrate on state and national standards. A teacher in a disadvantaged school reports that her students are not exposed to many educational experiences outside the classroom. MND allows inner city students to be a part of NASA directly. They are able to use the same information that scientists are using and this gives them inspiration. In all classrooms, the MND microsets move students out of their local area to explore global data and then zoom back into their homes realizing that they are a part of the

  4. Spatially complex distribution of dissolved manganese in a fjord as revealed by high-resolution in situ sensing using the autonomous underwater vehicle Autosub.

    Science.gov (United States)

    Statham, P J; Connelly, D P; German, C R; Brand, T; Overnell, J O; Bulukin, E; Millard, N; McPhail, S; Pebody, M; Perrett, J; Squire, M; Stevenson, P; Webb, A

    2005-12-15

    Loch Etive is a fjordic system on the west coast of Scotland. The deep waters of the upper basin are periodically isolated, and during these periods oxygen is lost through benthic respiration and concentrations of dissolved manganese increase. In April 2000 the autonomous underwater vehicle (AUV) Autosub was fitted with an in situ dissolved manganese analyzer and was used to study the spatial variability of this element together with oxygen, salinity, and temperature throughout the basin. Six along-loch transects were completed at either constant height above the seafloor or at constant depth below the surface. The ca. 4000 in situ 10-s-average dissolved Mn (Mnd) data points obtained provide a new quasi-synoptic and highly detailed view of the distribution of manganese in this fjordic environment not possible using conventional (water bottle) sampling. There is substantial variability in concentrations (600 nM) and distributions of Mnd. Surface waters are characteristically low in Mnd reflecting mixing of riverine and marine end-member waters, both of which are low in Mnd. The deeper waters are enriched in Mnd, and as the water column always contains some oxygen, this must reflect primarily benthic inputs of reduced dissolved Mn. However, this enrichment of Mnd is spatially very variable, presumably as a result of variability in release of Mn coupled with mixing of water in the loch and removal processes. This work demonstrates how AUVs coupled with chemical sensors can reveal substantial small-scale variability of distributions of chemical species in coastal environments that would not be resolved by conventional sampling approaches. Such information is essential if we are to improve our understanding of the nature and significance of the underlying processes leading to this variability.

  5. Progressive Apraxia of Speech as a Sign of Motor Neuron Disease

    Science.gov (United States)

    Duffy, Joseph R.; Peach, Richard K.; Strand, Edythe A.

    2007-01-01

    Purpose: To document and describe in detail the occurrence of apraxia of speech (AOS) in a group of individuals with a diagnosis of motor neuron disease (MND). Method: Seven individuals with MND and AOS were identified from among 80 patients with a variety of neurodegenerative diseases and AOS (J. R. Duffy, 2006). The history, presenting…

  6. NEUROBEHAVIORAL RELATIONSHIPS AND PUBERTY - ANOTHER TRANSFORMATION

    NARCIS (Netherlands)

    SOORANILUNSING, RJ

    In a follow-up study of the Groningen Perinatal Project (GPP) on minor neurological dysfunction (MND) at 12 and 14 years the onset of puberty appeared to play a role. The children were selected on the presence (n = 185) and absence (n = 185) of MND at 9 years. Puberty was defined by the presence of

  7. Ülikool valis viis professorit ja nimetas emeriitprofessori (TPM)

    Index Scriptorium Estoniae

    2004-01-01

    Tartu Ülikooli nõukogu nimetas professoriteks tagasi Eesti ajaloo professori Tiit Rosenbergi, eesti keele kui võõrkeele professori Birute Klaasi, rakendusökoloogia professori Olevi Kulli ja majanduspoliitika professori Jüri Sepa. Balti poliitika professoriks sai Andres Kasekamp. Ülikooli mikrobioloogia instituudi juhatajale professor Marika Mikelsaarele anti emeriitprofessori nimetus

  8. Vanemuise teatri juurdeehituse kutsutud arhitektuurikonkurss = Invitational architecture competition for the addition to the Vanemuine theatre / Peeter Pere

    Index Scriptorium Estoniae

    Pere, Peeter, 1957-

    2009-01-01

    Arhitektuurikonkursi žürii liige Peeter Pere võistluse eesmärgist, konkursil 1. preemia pälvinud Jüri Okase ja Marika Lõokese (Okas & Lõoke) võistlustööst ja konkursil osalenud arhitektuuribüroode Kolm Pluss Üks, Kavakava ja Lunge & Ko võistlustöödest

  9. Selective impairment of verb processing associated with pathological changes in Brodmann areas 44 and 45 in the motor neurone disease-dementia-aphasia syndrome.

    Science.gov (United States)

    Bak, T H; O'Donovan, D G; Xuereb, J H; Boniface, S; Hodges, J R

    2001-01-01

    We report six patients with clinically diagnosed and electrophysiologically confirmed motor neurone disease (MND), in whom communication problems were an early and dominant feature. All patients developed a progressive non-fluent aphasia culminating in some cases in complete mutism. In five cases, formal testing revealed deficits in syntactic comprehension. Comprehension and production of verbs were consistently more affected those that of nouns and this effect remained stable upon subsequent testing, despite overall deterioration. The classical signs of MND, including wasting, fasciculations and severe bulbar symptoms, occurred over the following 6-12 months. The behavioural symptoms ranged from mild anosognosia to personality change implicating frontal-lobe dementia. In three cases, post-mortem examination has confirmed the clinical diagnosis of MND-dementia. In addition to the typical involvement of motor and premotor cortex, particularly pronounced pathological changes were observed in the Brodmann areas 44 (Broca's area) and 45. The finding of a selective impairment of verb/action processing in association with the dementia/aphasia syndrome of MND suggests that the neural substrate underlying verb representation is strongly connected to anterior cortical motor systems.

  10. Symptomatic treatments for amyotrophic lateral sclerosis/motor neuron disease.

    Science.gov (United States)

    Ng, Louisa; Khan, Fary; Young, Carolyn A; Galea, Mary

    2017-01-10

    Motor neuron disease (MND), which is also known as amyotrophic lateral sclerosis (ALS), causes a wide range of symptoms but the evidence base for the effectiveness of the symptomatic treatment therapies is limited. To summarise the evidence from Cochrane Systematic Reviews of all symptomatic treatments for MND. We searched the Cochrane Database of Systematic Reviews (CDSR) on 15 November 2016 for systematic reviews of symptomatic treatments for MND. We assessed the methodological quality of the included reviews using the Assessment of Multiple Systematic Reviews (AMSTAR) tool and the GRADE approach. We followed standard Cochrane study (review) selection and data extraction procedures. We reported findings narratively and in tables. We included nine Cochrane Systematic Reviews of interventions to treat symptoms in people with MND. Three were empty reviews with no included randomised controlled trials (RCTs); however, all three reported on non-RCT evidence and the remaining six included mostly one or two studies. We deemed all of the included reviews of high methodological quality. Drug therapy for painThere is no RCT evidence in a Cochrane Systematic Review exploring the efficacy of drug therapy for pain in MND. Treatment for crampsThere is evidence (13 RCTs, N = 4012) that for the treatment of cramps in MND, compared to placebo:- memantine and tetrahydrocannabinol (THC) are probably ineffective (moderate-quality evidence);- vitamin E may have little or no effect (low-quality evidence); and- the effects of L-threonine, gabapentin, xaliproden, riluzole, and baclofen are uncertain as the evidence is either very low quality or the trial specified the outcome but did not report numerical data.The review reported adverse effects of riluzole, but it is not clear whether other interventions had adverse effects. Treatment for spasticityIt is uncertain whether an endurance-based exercise programme improved spasticity or quality of life, measured at three months after the

  11. Incidence of and risk factors for Motor Neurone Disease in UK women: a prospective study

    Directory of Open Access Journals (Sweden)

    Doyle Pat

    2012-05-01

    Full Text Available Abstract Background Motor neuron disease (MND is a severe neurodegenerative disease with largely unknown etiology. Most epidemiological studies are hampered by small sample sizes and/or the retrospective collection of information on behavioural and lifestyle factors. Methods 1.3 million women from the UK Million Women Study, aged 56 years on average at recruitment, were followed up for incident and/or fatal MND using NHS hospital admission and mortality data. Adjusted relative risks were calculated using Cox regression models. Findings During follow-up for an average of 9·2 years, 752 women had a new diagnosis of MND. Age-specific rates increased with age, from 1·9 (95% CI 1·3 – 2·7 to 12·5 (95% CI 10·2 – 15·3 per 100,000 women aged 50–54 to 70–74, respectively, giving a cumulative risk of diagnosis with the disease of 1·74 per 1000 women between the ages of 50 and 75 years. There was no significant variation in risk of MND with region of residence, socio-economic status, education, height, alcohol use, parity, use of oral contraceptives or hormone replacement therapy. Ever-smokers had about a 20% greater risk than never smokers (RR 1·19 95% CI 1·02 to 1·38, p = 0·03. There was a statistically significant reduction in risk of MND with increasing body mass index (pfor trend = 0·009: obese women (body mass index, 30 kg/m2 or more had a 20% lower risk than women of normal body mass index (20 to 2(RR 0·78 95% CI 0·65-0·94; p = 0·03. This effect persisted after exclusion of the first three years of follow-up. Interpretation MND incidence in UK women rises rapidly with age, and an estimated 1 in 575 women are likely to be affected between the ages of 50 and 75 years. Smoking slightly increases the risk of MND, and adiposity in middle age is associated with a lower risk of the disease.

  12. Juustutööstur Muraka südamevalu / Heidit Kaio

    Index Scriptorium Estoniae

    Kaio, Heidit, 1971-

    2011-01-01

    Euroopa Toiduohutusamet (EFSA) ei tunnustanud Südamejuustu vererõhku langetavat toimet. Nii Südamejuustu tootva E-Piima juht Margus Murakas kui ka teadlane Marika Mikelsaar on otsusest nördinud. M. Mikelsaar räägib Tensia bakteri uuringutest. EFSA pole tunnustanud 99% talle esitatud väidetest mõne toiduaine kasulikkuse kohta

  13. Determinants of selenium status in healthy adults

    Directory of Open Access Journals (Sweden)

    Hoeg Antonia

    2011-07-01

    Full Text Available Abstract Background Selenium (Se status in non-deficient subjects is typically assessed by the Se contents of plasma/serum. That pool comprises two functional, specific selenoprotein components and at least one non-functional, non-specific components which respond differently to changes in Se intake. A more informative means of characterizing Se status in non-deficient individuals is needed. Methods Multiple biomarkers of Se status (plasma Se, serum selenoprotein P [SEPP1], plasma glutathione peroxidase activity [GPX3], buccal cell Se, urinary Se were evaluated in relation to selenoprotein genotypes (GPX1, GPX3, SEPP1, SEP15, dietary Se intake, and parameters of single-carbon metabolism in a cohort of healthy, non-Se-deficient men (n = 106 and women (n = 155. Conclusions Plasma Se concentration was 142.0 ± 23.5 ng/ml, with GPX3 and serum-derived SEPP1 calculated to comprise 20% and 34%, respectively, of that total. The balance, comprised of non-specific components, accounted for virtually all of the interindividual variation in total plasma Se. Buccal cell Se was associated with age and plasma homocysteine (hCys, but not plasma Se. SEPP1 showed a quadratic relationship with body mass index, peaking at BMI 25-30. Urinary Se was greater in women than men, and was associated with metabolic body weight (kg0.75, plasma folate, vitamin B12 and hCys (negatively. One GPX1 genotype (679T/T was associated with significantly lower plasma Se levels than other allelic variants. Selenium intake, estimated from food frequency questionnaires, did not predict Se status as indicated by any biomarker. These results show that genotype, methyl-group status and BMI contribute to variation in Se biomarkers in Se-adequate individuals.

  14. Tõuloom 2012 / Krista Sepp

    Index Scriptorium Estoniae

    Sepp, Krista

    2012-01-01

    Eesti Tõuloomakasvatuse Liidu poolt Ülenurme Põllumajandusmuuseumis 1. septembril korraldatud tõuloomade konkursil Tartu sügisnäitus. Tõuloom 2012 tunnustatud Eesti Hobusekasvatajate Seltsi liikmetest ning trakeeni, araabia tori, eesti ja eesti raskeveo tõugu hobustest

  15. Eesti nimekaim ilukirurg jagab enesekindlust / Peep Pree ; intevjueerinud Priit Pullerits

    Index Scriptorium Estoniae

    Pree, Peep, 1958-

    2006-01-01

    Vestlus Tartu esteetilise kirurgia erakliiniku Clinica juhatajaga tööst, vastutustundest, ebaõnnestumistest. Kommenteerivad Tartu linnapea Laine Jänes ja Tartu Ülikooli arstiteaduskonna emeriitprofessor Ennu Sepp

  16. Experiences and reflections of patients with motor neuron disease on breaking the news in a two-tiered appointment: a qualitative study.

    Science.gov (United States)

    Seeber, Antje A; Pols, A Jeannette; Hijdra, Albert; Grupstra, Hepke F; Willems, Dick L; de Visser, Marianne

    2016-02-02

    Breaking bad news should be fine-tuned to the individual patient, contain intelligible information, include emotional support and offer a tailor-made treatment plan. To achieve this goal in motor neuron disease (MND), neurologists of the amyotrophic lateral sclerosis (ALS) centre Amsterdam deliver the message on 2 separate visits within 14 days. To evaluate how patients with MND react to and view disclosure of the diagnosis, in this 2-tiered approach. Non-participating observations and in-depth interviews with patients were conducted in 1 tertiary ALS referral centre. Qualitative analysis consisted of inductive analysis of observation reports and verbatim typed out interviews. 10 2-tiered appointments were observed and 21 Dutch patients with MND interviewed. They experienced the straightforward message to be suffering from a fatal disease as devastating, yet unavoidable. The prospect of a short-term second appointment offered structure for the period immediately following the diagnosis. The time between appointments provided the opportunity for a first reorientation on their changed perspective on their life. The second appointment allowed for detailed discussions about various aspects of MND and a tailor-made treatment plan. The 2-tiered approach fits well with the way in which Dutch patients with MND process the disclosure of their diagnosis, gather information and handle the changed perspective on their life. It may serve as a model for other life-limiting diseases. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  17. Frontotemporal lobar degeneration with ubiquitin pathology: an autopsy case presenting with semantic dementia and upper motor neuron signs with a clinical course of 19 years.

    Science.gov (United States)

    Yokota, Osamu; Tsuchiya, Kuniaki; Itoh, Yoshinori; Ishizu, Hideki; Akiyama, Haruhiko; Ikeda, Manabu; Kuzuhara, Shigeki; Otomo, Eiichi

    2006-12-01

    We report a case of a right-handed 74-year-old man who showed semantic dementia with a disease duration of 19 years. He initially presented with excessive use of pronouns and semantic paraphasia at the age of 55 years. Impairment of object recognition developed 5 years after the onset. Face recognition impairment and stereotypic behaviors developed 11 years after onset, and pyramidal signs 2 years before death. Pathological examination disclosed circumscribed severe atrophy in not only the bilateral temporal tips but also in the left precentral gyrus and pars opercularis in a motor speech field. Pyramidal tract involvement and loss of Betz cells were also evident. On the other hand, neurons in the anterior horns and hypoglossal nuclei were spared in number, although astrocytes were mildly proliferated. Ubiquitin-positive lesions were observed in the hippocampus, and frontal and temporal cortices. Neither Bunina bodies nor Pick bodies were present. These features clinically fit the international diagnostic criteria of semantic dementia and, histopathologically, frontotemporal lobar degeneration with motor neuron disease (FTLD-MND). This case suggests that (1) the distribution of cortical lesions associated with language disturbance is not uniform in FTLD-MND. It may be that only some cases of FTLD with ubiquitin pathology develop semantic dementia despite the high incidence of language disturbance, and (2) the precentral gyrus can be severely affected in FTLD-MND. After reviewing previous cases of FTLD-MND with a clinical course of more than 10 years, we also noticed that (3) FTLD-MND cases with a long disease duration often show upper motor neuron-predominant involvement.

  18. Determinants of accepting non-invasive ventilation treatment in motor neurone disease: a quantitative analysis at point of need.

    Science.gov (United States)

    Cousins, Rosanna; Ando, Hikari; Thornton, Everard; Chakrabarti, Biswajit; Angus, Robert; Young, Carolyn

    2013-01-01

    Objectives : Motor neurone disease (MND) progressively damages the nervous system causing wasting to muscles, including those used for breathing. There is robust evidence that non-invasive ventilation (NIV) relieves respiratory symptoms and improves quality of life in MND. Nevertheless, about a third of those who would benefit from NIV decline the treatment. The purpose of the study was to understand this phenomenon. Design : A cross-sectional quantitative analysis. Methods : Data including age, sex, MND symptomatology, general physical and mental health and psychological measures were collected from 27 patients and their family caregivers at the point of being offered ventilatory support based on physiological markers. Results : Quantitative analyses indicated no difference in patient characteristics or symptomatology between those who tolerated ( n  = 17) and those who declined ( n  = 10) NIV treatment. A comparison of family caregivers found no differences in physical or mental health or in caregiving distress, emphasising that this was high in both groups; however, family caregivers supporting NIV treatment were significantly more resilient, less neurotic and less anxious than family caregivers who did not. Regression analyses, forcing MND symptoms to enter the equation first, found caregiver resilience:commitment the strongest predictor of uptake of NIV treatment adding 22% to the 56% explained variance. Conclusion : Patients who tolerated NIV treatment had family caregivers who cope through finding meaning and purpose in their situation. Psychological support and proactive involvement for family caregivers in the management of the illness situation is indicated if acceptance of NIV treatment is to be maximised in MND.

  19. 19.-25. IX toimub Rüütelkonna hoones Kumu pärlite nädal...

    Index Scriptorium Estoniae

    2005-01-01

    23. IX kõneleb Anu Allikvee teemal "Eestlane baltisaksa kunstnike vaatepiiris"; 24. IX tutvustab Mai Levin Eugen Dückeri maale, 25. IX Ene Lamp Konrad Mäge. Vt. ka lk. 24 Tähtede nädal 26. IX-2. X - kohtumisõhtutel esinevad Marika ja Heinz Valk, Jüri Kuuskemaa, Sirje Helme, Pekka Vapaavuori, Inge Teder, Rain Lõhmus

  20. Mis on elus olulisim / Aita Kivi

    Index Scriptorium Estoniae

    Kivi, Aita, 1954-

    2002-01-01

    Sisu : Mitch Albom. Teisipäevad Morrie'ga; Santa Montefiore. Oota mind ombupuu all; Ridley Pearson. Tont teab kus; Sebastian Faulks. Linnulaul; Kerttu Rakke. Iluasjake; Merike Hanni. Kooliraha; Viivi Luik. Ajaloo ilu; Hermann Hesse. Stepihunt; Eesti luulet läbi aegade / [koostanud Marika Vingissar; Philip K. Dick. Ubik; Marion Zimmer Bradley. Avaloni udud; Kuus eesti luuletajat / koostanud Anne Lange

  1. Pansionaat Pärnus : Seedri 4 = Pension in Pärnu : Seedri 4 / Liina Jänes

    Index Scriptorium Estoniae

    Jänes, Liina, 1977-

    2008-01-01

    Arhitekt Kalle Vellevoog, kaasa töötas Margus Tamm. Sisearhitekt Tiiu Truus. Maastikuarhitekt Vaike Parker. Konstruktor Ahti Lääne. Peatöövõtja: YIT Ehitus AS. Eesti Kultuurkapitali arhitektuuri sihtkapitali 2007. a. arhitektuuripreemia. Žürii liikme Marika Lõokese arvamus. Asendi- ja II korruse plaan, lõige, 3 värv. välisvaadet, sisevaade

  2. Pink Pungi näitusel valgub veri linale / Raimu Hanson

    Index Scriptorium Estoniae

    Hanson, Raimu, 1957-

    2006-01-01

    Kunstirühmituse Pink Punk (Sandra Jõgeva, Kristin Kalamees, Aino Ingrid Sepp, Kaarel Sammet) näitusest Y-galeriis. Lähemalt videoinstallatsioonist "Must turg" ja ruumiinstallatsioonist "Elulähedane kogemus"

  3. Kabja tervishoiu koolitus / Sanna Turu

    Index Scriptorium Estoniae

    Turu, Sanna

    2013-01-01

    Eesti Raskeveohobuse Seltsi poolt 25. mail Raplamaal Piibelehe Puhkekemajas korraldatud koolitusest, kus hobuveterinaar Triin Tohver ja professionaalne sepp Stephan Ernest Saksamaalt tegid põhjaliku ülevaate hobuse kabja tervishoiu teemadel

  4. What Intellectual Property lawyers can Learn from Barbra Streisand ...

    African Journals Online (AJOL)

    ... lawyers can Learn from Barbra Streisand, Sepp Blatter, and the "Coca-Cola ... rights; Overly-aggressive enforcement; Rights holder over-reach; Litigation strategy; ... 'Trademark extortion'; 'Duty to police'; Streisand effect; Ambush marketing.

  5. Riho Pätsi koolimuusika fond tunnustab parimaid / Inge Raudsepp

    Index Scriptorium Estoniae

    Raudsepp, Inge, 1951-

    2015-01-01

    Riho Pätsi Koolimuusika Fond on üks Tallinna Ülikooli fondidest. Tänavused laureaadid on muusikaõpetaja Kadi Härma, klaveripedagoog Liina Jarovaja, helilooja Juhan Trump ning muusikapedagoogika uurija Anu Sepp

  6. Mida sportijad vajavad? / Evelin Kivilo-Paas

    Index Scriptorium Estoniae

    Kivilo-Paas, Evelin, 1979-

    2015-01-01

    Sportijate toitainete vajaduse kohta jagavad selgitusi Tallinna Ülikooli terviseteaduste ja spordi instituudi direktor ja spordibioloog Kristjan Port, Synlab Eesti laboriarst dr Anneli Raave-Sepp ja Spordimeditsiini SA spordiarst dr Krista Veevo

  7. Nutritional advice and treatment by dietitians to patients with amyotrophic lateral sclerosis/motor neurone disease: a survey of current practice in England, Wales, Northern Ireland and Canada.

    Science.gov (United States)

    Rio, A; Cawadias, E

    2007-02-01

    The management of amyotrophic lateral sclerosis/motor neurone disease (ALS/MND) has shifted from an attitude of nihilism to treatments that prolong survival and offer hope. Nutrition is an integral component of ALS/MND care requiring coordination among acute and community multi-disciplinary teams (MDT). Evidence-based nutrition guidelines exist for this patient group but their use among dietitians is unknown. The aim of this study was to survey the knowledge, practice and guideline use of dietitians working in ALS/MND centres/clinics across England, Wales, Northern Ireland (EWNI) and Canada. Dietetic contact details were obtained from the Motor Neurone Disease Association (MNDA) and the ALS Society of Canada (ALSSC) websites. Telephone interviews were conducted with 23 dietitians using a standardized questionnaire. Multi-disciplinary team membership was high (78%). Only 22% dietitians had >4-years experience in ALS/MND care. Dietitians reported using body weight, percentage weight loss (PWL) and body mass index (BMI) to assess nutritional status. Equations used to estimate energy and protein requirements differed. Most frequent dietary advice was high calorie, texture modification and prescription nutritional supplements. Artificial nutrition and hydration (ANH) was discussed when patients developed dysphagia, energy intake was inadequate, weight loss of 10% or forced vital capacity (FVC) was reduced. A percutaneous endoscopic gastrostomy (PEG) service was available at all clinics/centres. Nutritional assessment techniques and dietary advice should be standardized. Dietetic collaboration at national and international level is recommended to reduce professional isolation. Training and support in ALS/MND nutrition should be made available as part of post-dietetic registration. Further dietetic research is required to stimulate nutritional care.

  8. Analysis on energy consumption of drying process for dried Chinese noodles

    International Nuclear Information System (INIS)

    Wang, Zhenhua; Zhang, Yingquan; Zhang, Bo; Yang, Fuguang; Yu, Xiaolei; Zhao, Bo; Wei, Yimin

    2017-01-01

    Highlights: • Energy analysis of a tunnel dryer for dried Chinese noodles is completed. • Energy saving performance of dryers with different inlet air was compared. • MND was developed and evaluated, and the efficiency and throughput was improved. - Abstract: Drying is an important operation during the production of dried Chinese noodles, and the energy consumption from drying accounts for approximately 60% of the total energy consumption during the manufacturing process. To investigate the energy consumption and throughput of dryers for dried Chinese noodles, experiments were conducted using a new 130-m long tunnel dryer with two lines of noodles (ND) and an old 60-m long tunnel dryer with five lines of noodles (OD). The energy saving effects of a modified new 130-m long tunnel dryer (MND), which was only modified through the inclusion of automatic control for temperature and humidity without any modifications to the oil heater or ND dryer structure, were also compared. The energy saving effect was determined from the enthalpy difference between the inlet and outlet humid air of the ND and MND. Finally, the MND was found to be better than ND in terms of energy efficiency and throughput, and trends for the future of noodle drying were discussed.

  9. Electrospinning of Nanodiamond-Modified Polysaccharide Nanofibers with Physico-Mechanical Properties Close to Natural Skins

    Directory of Open Access Journals (Sweden)

    Mina Mahdavi

    2016-07-01

    Full Text Available Electrospinning of biopolymers has gained significant interest for the fabrication of fibrous mats for potential applications in tissue engineering, particularly for wound dressing and skin regeneration. In this study, for the first time, we report successful electrospinning of chitosan-based biopolymers containing bacterial cellulous (33 wt % and medical grade nanodiamonds (MND (3 nm; up to 3 wt %. Morphological studies by scanning electron microscopy showed that long and uniform fibers with controllable diameters from 80 to 170 nm were prepared. Introducing diamond nanoparticles facilitated the electrospinning process with a decrease in the size of fibers. Fourier transform infrared spectroscopy determined hydrogen bonding between the polymeric matrix and functional groups of MND. It was also found that beyond 1 wt % MND, percolation networks of nanoparticles were formed which affected the properties of the nanofibrous mats. Uniaxial tensile testing of the woven mats determined significant enhancement of the strength (from 13 MPa to 25 MP by dispersion of 1 wt % MND. The hydrophilicity of the mats was also remarkably improved, which was favorable for cell attachment. The water vapor permeability was tailorable in the range of 342 to 423 µg·Pa−1·s−1·m−1. The nanodiamond-modified mats are potentially suitable for wound healing applications.

  10. Electrospinning of Nanodiamond-Modified Polysaccharide Nanofibers with Physico-Mechanical Properties Close to Natural Skins

    Science.gov (United States)

    Mahdavi, Mina; Mahmoudi, Nafiseh; Rezaie Anaran, Farzad; Simchi, Abdolreza

    2016-01-01

    Electrospinning of biopolymers has gained significant interest for the fabrication of fibrous mats for potential applications in tissue engineering, particularly for wound dressing and skin regeneration. In this study, for the first time, we report successful electrospinning of chitosan-based biopolymers containing bacterial cellulous (33 wt %) and medical grade nanodiamonds (MND) (3 nm; up to 3 wt %). Morphological studies by scanning electron microscopy showed that long and uniform fibers with controllable diameters from 80 to 170 nm were prepared. Introducing diamond nanoparticles facilitated the electrospinning process with a decrease in the size of fibers. Fourier transform infrared spectroscopy determined hydrogen bonding between the polymeric matrix and functional groups of MND. It was also found that beyond 1 wt % MND, percolation networks of nanoparticles were formed which affected the properties of the nanofibrous mats. Uniaxial tensile testing of the woven mats determined significant enhancement of the strength (from 13 MPa to 25 MP) by dispersion of 1 wt % MND. The hydrophilicity of the mats was also remarkably improved, which was favorable for cell attachment. The water vapor permeability was tailorable in the range of 342 to 423 µg·Pa−1·s−1·m−1. The nanodiamond-modified mats are potentially suitable for wound healing applications. PMID:27399726

  11. Electrospinning of Nanodiamond-Modified Polysaccharide Nanofibers with Physico-Mechanical Properties Close to Natural Skins.

    Science.gov (United States)

    Mahdavi, Mina; Mahmoudi, Nafiseh; Rezaie Anaran, Farzad; Simchi, Abdolreza

    2016-07-07

    Electrospinning of biopolymers has gained significant interest for the fabrication of fibrous mats for potential applications in tissue engineering, particularly for wound dressing and skin regeneration. In this study, for the first time, we report successful electrospinning of chitosan-based biopolymers containing bacterial cellulous (33 wt %) and medical grade nanodiamonds (MND) (3 nm; up to 3 wt %). Morphological studies by scanning electron microscopy showed that long and uniform fibers with controllable diameters from 80 to 170 nm were prepared. Introducing diamond nanoparticles facilitated the electrospinning process with a decrease in the size of fibers. Fourier transform infrared spectroscopy determined hydrogen bonding between the polymeric matrix and functional groups of MND. It was also found that beyond 1 wt % MND, percolation networks of nanoparticles were formed which affected the properties of the nanofibrous mats. Uniaxial tensile testing of the woven mats determined significant enhancement of the strength (from 13 MPa to 25 MP) by dispersion of 1 wt % MND. The hydrophilicity of the mats was also remarkably improved, which was favorable for cell attachment. The water vapor permeability was tailorable in the range of 342 to 423 µg·Pa(-1)·s(-1)·m(-1). The nanodiamond-modified mats are potentially suitable for wound healing applications.

  12. "Habitarel" valitses kerge minimalism

    Index Scriptorium Estoniae

    2003-01-01

    17. mööbli- ja sisustusmess "Habitare" Helsingi Messikeskuses. Noorte sisekujundajate projektikonkursil "TILA+" parim Soome Kunstikõrgkooli õpilaste Marika Aro ja Nana Turuneni töö "Tulemüür". Eesti tootjate esindatus (TVMK kasevineerist tooli ja lauad, Toom Tekstiili villatekid ja padjad). Muljeid disainiüliõpilaselt Anni Kalmuselt, sisearhitekt Aili Aasojalt, TVMK reklaamijuhilt Viivi Rooselt. 4 ill

  13. Äripäev maakonnas : Pärnumaa / Jaana Pikalev

    Index Scriptorium Estoniae

    Pikalev, Jaana

    2007-01-01

    Pärnumaa edukamad firmad 2006. aastal. Vt. samas: Puuduvad töökäed tulevad kutsehariduskeskusest. Kommenteerivad Veljo Truudel, Marika Tettermann ja Tarmo Vanamõisa; Müügitulu headest kaubamärkidest; Menukuses kajastub emafirma edu; 2005. aasta edetabel; Tugeva meeskonnaga töörindel; Pärnumaa Gaselli TOPi juhib kinnisvarafirma. Küsimustele vastab Puls Brewery AS-i juht Aivo Varem

  14. Leningradi aktsioonid / Sandra Jõgeva

    Index Scriptorium Estoniae

    Jõgeva, Sandra, 1976-

    2006-01-01

    Eesti kunstnike väljapanekust "Empty Spaces and their Occupants" 12.-24. augustini 2006 a. toimuval Peterburi Maneezhi 6. rahvusvahelisel eksperimentaalkunsti festivalil, kuraator Maksim Surin. Osalevad Kaido Ole, Merike Estna, Meeland Sepp jt

  15. Arvuti ja tema kuju / Tõnu Kaalep

    Index Scriptorium Estoniae

    Kaalep, Tõnu, 1966-2018

    2000-01-01

    Disain on jõudnud arvutiteni. Arvutite iMac, iBook, Macintosh, Microlingi Cosmic Flex ATX jt. disainist. Disainer M. Pärn arvutite ja disaini suhetest, M. Sepp ostjate reageerimisest Cosmic Flex ATX disainile.

  16. Eesti Linnade Liidu, Eesti Omavalitsusliitude Ühenduse, Eesti Korteriühistute Liidu ja Eesti Gaasiliidu pöördumine = Obrashtshenije k Sojuzu Gorodov Estonii, Obedineniju Samoupravlenii Estonii, Sojuzu Kvartirnõhh Tovarishtshestv Estonii i Sojuzu

    Index Scriptorium Estoniae

    2003-01-01

    Pöördumises tehakse valitsusele ettepanek kavandada kodugaasiseadmete väljavahetamise projekt koos finantseerimise kavaga. Pöördumisele on alla kirjutanud Jaanus Tamkivi, Toomas Välimäe, Marit Otsing ja Allan Sepp

  17. Kasvukeskkond ja andekus / Marika Veisson

    Index Scriptorium Estoniae

    Veisson, Marika, 1949-

    2001-01-01

    Imikute ja väikelastega läbi viidud longituuduuringu eesmärgiks oli välja selgitada kasvukeskkonna faktorite mõju väikelapse intellekti arengule. Töös osalesid professorid M. Vikat, V. Kolga, teadur A. Vikat, doktor E. Tomberg, magistrandid M. Laane, K. Nugin ja I. Tuisk ning V. Vallner ja A. Veber

  18. Innovatsiooniosak tuleb appi / Marika Popp

    Index Scriptorium Estoniae

    Popp, Marika

    2008-01-01

    Innovatsiooniosak ( innovation vouchers) kujutab endast kinkekaarti ettevõtjale, selle alusel avaneb eriti väike- ja keskmise suurusega ning seni vähe või üldse mitte teadus- ja arendustööga kokku puutunud ettevõtteil saada esimene kogemus ning tekitada juurdepääs teadmiste allikale

  19. Vananemise vastu toiduga / Marika Makarova

    Index Scriptorium Estoniae

    Makarova, Marika

    2012-01-01

    Toitumisteaduste magistri David Wolfe poolt soovitatud vananemise märke aeglustavatest ning pidurdavatest supertoitudest ja toidulisanditest: kasekäsn e must pässik, reishi-seen,kakao, assai, avokaado, brokoli, sidrun, õun, õunamahl, õunasiider, õunaäärikas, maka e mugulkress, goji ja mooruspuu marjad; vetikad klorella ja spirulina; toidulisandid EDTA – etüleendiamiin-tetraäädikhape (Ethylenediaminetetraacetic acid), humiin- või fulvohape, MSM – metüülsulfonüülmetaan

  20. Kergitajad, paksendajad, tarretajad / Marika Makarova

    Index Scriptorium Estoniae

    Makarova, Marika

    2012-01-01

    Nii looduslikest (alginiinhape, guarkummi e guarjahu, jaanileivapuujahu, karrageen, ksantaankummi, kummiaraabik, pektiin) kui tööstuslikult toodetud paksendajatest, tarretajatest ja kergitusainetest

  1. Arenguindeks = Development index / Marika Kivilaid

    Index Scriptorium Estoniae

    Kivilaid, Marika

    2005-01-01

    Kokkuvõte kohalike omavalitsusüksuste arenguindeksi, mis on kolme näitaja (ettevõtete realiseerimise netokäive elaniku kohta, üksikisiku tulumaksu laekumine elaniku kohta, registreeritud töötuse määr) pingeridade kohapunktide summa, arvutamise tulemustest

  2. Sukeldumisharjutused prantslaste fotopeol / Marika Alver

    Index Scriptorium Estoniae

    Alver, Marika

    2006-01-01

    37. fotofestivalist Arles'is Prantsusmaal, mille peakuraatoriks oli fotograaf ja kineast Raymond Depardon. Näitusel on esitatud tema vanade sõprade David Angeli, Guy Le Querrec'i, Jean Gaumy ja David Burnetti töid, aga ka kaasaegset ühiskonda peegeldavate fotograafide Gilles Leimdorferi, Philippe Chanceli, Olivier Jobardi jt töid

  3. Kivid sinu sees / Marika Makarova

    Index Scriptorium Estoniae

    Makarova, Marika

    2011-01-01

    Sapi- ja neerukivide tekke põhjustest, ravist nii tavameditsiini kui ka Steineri poolt loodud antroposoofilise meditsiini vahenditega ning mida saab teha, et kividest hoiduda. Nõuannavad Ida-Tallinna Keskhaigla kirurgid Rein Lumiste ja Toomas Tamm ning perearstikeskuse Medicum perearst Pille Soone

  4. Selenium, selenoenzymes, oxidative stress and risk of neoplastic progression from Barrett's esophagus: results from biomarkers and genetic variants.

    Directory of Open Access Journals (Sweden)

    Yumie Takata

    Full Text Available Clinical trials have suggested a protective effect of selenium supplementation on the risk of esophageal cancer, which may be mediated through the antioxidant activity of selenoenzymes. We investigated whether serum selenium concentrations, selenoenzyme activity, oxidative stress and genetic variation in selenoenzymes were associated with the risk of neoplastic progression to esophageal adenocarcinoma (EA and two intermediate endpoints, aneuploidy and tetraploidy. In this prospective cohort study, during an average follow-up of 7.3 years, 47 EA cases, 41 aneuploidy cases and 51 tetraploidy cases accrued among 361 participants from the Seattle Barrett's Esophagus Research Study who were free of EA at the time of blood draw and had at least one follow-up visit. Development to EA was assessed histologically and aneuploidy and tetraploidy by DNA content flow cytometry. Serum selenium concentrations were measured using atomic absorption spectrometry, activity of glutathione peroxidase (GPX 1 and GPX3 by substrate-specific coupled test procedures, selenoprotein P (SEPP1 concentrations and protein carbonyl content by ELISA method and malondialdehyde concentrations by HPLC. Genetic variants in GPX1-4 and SEPP1 were genotyped. Serum selenium was not associated with the risk of neoplastic progression to EA, aneuploidy or tetraploidy (P for trend = 0.25 to 0.85. SEPP1 concentrations were positively associated with the risk of EA [hazard ratio (HR = 3.95, 95% confidence intervals (CI = 1.42-10.97 comparing the third tertile with the first] and with aneuploidy (HR = 6.53, 95% CI = 1.31-32.58, but not selenoenzyme activity or oxidative stress markers. No genetic variants, overall, were associated with the risk of neoplastic progression to EA (global p = 0.12-0.69. Our results do not support a protective effect of selenium on risk of neoplastic progression to EA. Our study is the first to report positive associations of plasma SEPP1

  5. K. Linda Kivi autoriõhtu Tartu College´is / Eda Sepp ; fotod: Eda Sepp

    Index Scriptorium Estoniae

    Sepp, Eda

    2006-01-01

    19. jaanuaril 2006, Linda Kivi kolmanda raamatu "The Inner Green: Exploring Home in the Columbia Mountains" raamatuesitlusest. Korraldajateks Toronto Ülikooli Eesti Õppetool, Tartu Instituut, Tartu College´i laenuraamatukogu

  6. Snegurotshkad, plast ja punalipud ERKI moeshõul / Triin Thalheim

    Index Scriptorium Estoniae

    Thalheim, Triin, 1982-

    2005-01-01

    Sõna ja pildiga tutvustatakse Vene Kultuurikeskuses ERKI moeshõul esitatud Vassilissa, Kirill Safonovi, Kati Ilvese, Anna Roometi, Marte Kisandi, Pille Jürisoo, Karen Milistveri, Piret Paali, Erikka Bahnseni, Mikko Seppä, Hao Zhangi kollektsioone

  7. Eesti elektrisüsteemi juhtimiskeskus = Estonian electrical system command centre

    Index Scriptorium Estoniae

    2010-01-01

    Tallinnas Kadaka tee 42B1asuva Eesti elektrisüsteemi juhtimiskeskuse sisekujundusest. Spetsiaalsed kaarjad lauad on sisearhitektide projekteeritud. Sisearhitektid: Priit Põldme, Reet Sepp (Joonprojekt), nende tähtsamate tööde loetelu

  8. "Nägemus" EKA galeriis

    Index Scriptorium Estoniae

    2003-01-01

    Tartu Kõrgema Kunstikooli tekstiilikunsti osakonna gobeläänide näitus "Nägemus". Osalejad: Triinu Pungits, Signe Vilde, Jaanika Terasmaa, Leeda Ots, Gerli Aimla, Merike Uiga, Irina Vizner-Laur, Mari Vaaderpall, Heike Sepp

  9. Louis Blajan, Dottore in Medicina Veterinaria: Il dinamico veterinario che seppe traghettare l’Organizzazione Mondiale per la Sanità Animale (Office International des Épizooties: OIE nel mondo moderno

    Directory of Open Access Journals (Sweden)

    Anon.

    2010-03-01

    Full Text Available Nato il 10 aprile 1924 a Lahage (nell’Alta Garonna, in Francia, Louis Blajan si è spento lo scorso 10 febbraio 2010 a Mont-de-Marsan.Dopo aver frequentato il Lycée Pierre de Fermat di Tolosa, nel 1948 Louis completa gli studi presso la Scuola di Veterinaria di Tolosa. Nel 1949, si diploma all’Institut d’élevage et de médecine vétérinaire des pays tropicaux (IEMVT e dal 1949 al 1952 è nel territorio d’oltremare francese del Mali. Tornato in Francia, dal 1953 al 1968 Louis esercita come veterinario di Stato presso il Ministero dell’Agricoltura, responsabile per l’afta epizootica, la peste suina e la malattia di Newcastle, nonché come Presidente del Comitato consultivo per le malattie infettive. In seguito, viene nominato Ispettore capo veterinario e Responsabile per la politica di controllo delle frontiere.Nel 1952, Louis sposa Janine, moglie affezionata che lo appoggia con ardore in ogni fase della sua carriera e perde la vita in un incidente un mese prima che il marito vada in pensione nel 1990.Dal 1968 al 1977, Louis è Direttore tecnico di Cofranimex (Compagnie Française pour l’importation et l’exportation des animaux reproducteurs et leur semence e dal 1977 al 1978 riveste il ruolo di Direttore dell’Association pour le développement des techniques de l’élevage français (ADETEF.Louis entra a lavorare nell’Office International des Épizooties (oggi noto come Organizzazione Mondiale per la Sanità Animale o ‘OIE’ dove, dal 1978 al 1980, occupa la posizione di Direttore del Dipartimento tecnico. Due anni più tardi, nel 1980, viene eletto Direttore Generale, coronando il sogno di ogni professionista della medicina veterinaria e raggiungendo l’apice della propria carriera. Rieletto nel 1985, si ritira dalla vita lavorativa nel 1990.Durante gli anni in cui fu a capo dell’OIE, Louis seppe trasformare quella che all’epoca era una struttura antiquata in un’organizzazione internazionale moderna ed

  10. Data Redistribution through MY NASA DATA: Striving to bring authentic NASA data into education

    Science.gov (United States)

    Lewis, P. M.; Oostra, D.; Oots, P.; Chambers, L. H.; Moore, S.; Crecelius, S.; Taylor, J.

    2012-12-01

    The Mentoring and inquirY using NASA Data on Atmospheric and Earth science for Teachers and Amateurs (MY NASA DATA or MND) project was launched in 2004 to bring authentic data into K-12 education. The MND website features a Live Access Server (LAS), an open source tool which allows users to customize data sets to suit their individual needs, choosing from among 200 global Level 3 data sets. Approximately 120 lesson plans that utilize the available parameters are offered to help teachers and students get started with data exploration. Grade appropriate data documentation is also provided (with continual efforts to improve it to better meet the needs of this target audience). Through inquiry and lesson utilization, educators have several connection points to the data. As classrooms shift to problem-based and inquiry learning, the need for a data visualizer/server increases. Through numerous and growing connections to NASA satellite missions, and with access to data as a built-in feature, MND effectively fills this niche to provide a first level of data re-use that is friendly to the K-12 community. Offering a wide variety of data sets allows MND to support many science topics within the K-12 curriculum while extending the use of scientific data from NASA Earth science satellites. Lessons, created by educators across the country, allow MND to connect with the classroom teacher and to meet their data needs. As technology continues to evolve, a second level of data re-use becomes both interesting and possible. Thus, the MND team is now exploring new web and mobile platforms that can be built and distributed on an accelerated time cycle to keep up with information technology developments. With implementation of these new platforms come challenges in promoting new items to the education community, the public, and other potential users. Included in the list of challenges are: ever-evolving technology, prediction of the market, web/mobile platforms, and time-to-market for

  11. Маленьким кинотеатрам грозит закрытие / Ханнели Руди

    Index Scriptorium Estoniae

    Руди, Ханнели

    2011-01-01

    Üha enam levib maailmas DCP (Digital Cinema Package) ehk filmi digiteeritud salvestis. Eestis on vaid Tallinna ja Tartu kinodes tehnika, millega vaadata DCP filme. Probleemi analüüsib Kultuuriministeeriumi filminõunik Edit Sepp

  12. Relationships between myonuclear domain size and fibre properties in the muscles of Thoroughbred horses.

    Science.gov (United States)

    Kawai, M; Kuwano, A; Hiraga, A; Miyata, H

    2010-11-01

    The myonuclear domain (MND) is the region of cytoplasm governed by a single myonucleus. Myonuclear domain size is an important factor for muscle fibre plasticity because each myonucleus has limitations in the capacity of protein synthesis. Previous studies have demonstrated that differences in MND size exist in different fibre types in several species, including horses. To understand the basic mechanism of muscle plasticity, the relationships between MND size, muscle fibre type population and metabolic properties of skeletal muscles throughout the whole body in Thoroughbred horses were examined. Post mortem samples were taken from 20 muscles in 3 Thoroughbred horses aged 3-5 years of age. Fibre type population was determined on serial cross sections of each muscle sample, stained for monoclonal antibodies to each myosin heavy chain isoform. Oxidative (succinic dehydrogenase; SDH) and glycolytic (phosphofructokinase; PFK) enzyme activities were determined spectrophotometrically in each muscle sample. Furthermore, 30 single fibres were isolated from each muscle under stereomicroscopy and then fibre volume and myonuclear number for a given length analysed under confocal microscopy. The MND size of each single fibre was measured after normalisation of sarcomere length to 2.8 µm by staining with membrane-specific dye. Immunohistochemical staining indicated that soleus, vastus lateralis and gluteus medius muscles had the highest percentage of type I, IIa and IIx muscle fibre, respectively. Biochemical analysis indicated highest activities of SDH and PFK in diaphragm and longissimus lumborum muscles, respectively. MNDs were largest in the splenius muscle and smallest in the soleus and masseter muscles. Myonuclear domain size is significantly related to type I muscle fibre population, but not to SDH activities of the muscles. The MND size of muscle fibre depends on fibre type population rather than mitochondrial enzyme activities. © 2010 EVJ Ltd.

  13. Peaminister Parts : lapsed olgu meist targemad / Juhan Parts ; interv. Toomas Sildam

    Index Scriptorium Estoniae

    Parts, Juhan, 1966-

    2003-01-01

    Intervjuus tunnistab peaminister Juhan Parts end roheliseks poliitikuks, nimetab valitsusliitu parimaks võimalikuks ja soovitab tudengitel kõigepealt õppida ning annab valitsuse 100 päeva hindeks "neli miinus". Kommenteerivad: Evelyn Sepp, Tarmo Loodus, Ivari Padar

  14. Mida ootab lapsevanem? / Raivo Juurak

    Index Scriptorium Estoniae

    Juurak, Raivo, 1949-

    2009-01-01

    Eesti koostöö kogu programmijuht Mati Salundi ja Tallinna Ülikooli sotsiaaltöö instituudi dotsent Anne Tiko viisid möödunud kevadel läbi uuringu, kus selgitasid, mida ootavad 1. klassi astuvate laste vanemad lasteaialt, koolilt, õpetajalt, kohalikult omavalitsuselt. Uuringu tulemusi kommenteerisid vestlusringis Mati Salundi, Lastevanemate Liidu koolitusjuht Kristiine Vahtramäe ja uuringu retsensent, Tallinna Ülikooli kasvatusteaduse instituudi professor Marika Veisson

  15. A metabolomic comparison of mouse models of the Neuronal Ceroid Lipofuscinoses

    Energy Technology Data Exchange (ETDEWEB)

    Salek, Reza M.; Pears, Michael R. [University of Cambridge, Department of Biochemistry and Cambridge Systems Biology Centre (United Kingdom); Cooper, Jonathan D. [King' s College London, Pediatric Storage Disorders Laboratory, Department of Neuroscience, Institute of Psychiatry (United Kingdom); Mitchison, Hannah M. [Royal Free and University College Medical School, Department of Paediatrics and Child Health (United Kingdom); Pearce, David A. [Sanford School of Medicine of the University of South Dakota, Department of Pediatrics (United States); Mortishire-Smith, Russell J. [Johnson and Johnson PR and D (Belgium); Griffin, Julian L., E-mail: jlg40@mole.bio.cam.ac.uk [University of Cambridge, Department of Biochemistry and the Cambridge Systems Biology Centre (United Kingdom)

    2011-04-15

    The Neuronal Ceroid Lipofuscinoses (NCL) are a group of fatal inherited neurodegenerative diseases in humans distinguished by a common clinical pathology, characterized by the accumulation of storage body material in cells and gross brain atrophy. In this study, metabolic changes in three NCL mouse models were examined looking for pathways correlated with neurodegeneration. Two mouse models; motor neuron degeneration (mnd) mouse and a variant model of late infantile NCL, termed the neuronal ceroid lipofuscinosis (nclf) mouse were investigated experimentally. Both models exhibit a characteristic accumulation of autofluorescent lipopigment in neuronal and non neuronal cells. The NMR profiles derived from extracts of the cortex and cerebellum from mnd and nclf mice were distinguished according to disease/wildtype status. In particular, a perturbation in glutamine and glutamate metabolism, and a decrease in {gamma}-amino butyric acid (GABA) in the cerebellum and cortices of mnd (adolescent mice) and nclf mice relative to wildtype at all ages were detected. Our results were compared to the Cln3 mouse model of NCL. The metabolism of mnd mice resembled older (6 month) Cln3 mice, where the disease is relatively advanced, while the metabolism of nclf mice was more akin to younger (1-2 months) Cln3 mice, where the disease is in its early stages of progression. Overall, our results allowed the identification of metabolic traits common to all NCL subtypes for the three animal models.

  16. A metabolomic comparison of mouse models of the Neuronal Ceroid Lipofuscinoses

    International Nuclear Information System (INIS)

    Salek, Reza M.; Pears, Michael R.; Cooper, Jonathan D.; Mitchison, Hannah M.; Pearce, David A.; Mortishire-Smith, Russell J.; Griffin, Julian L.

    2011-01-01

    The Neuronal Ceroid Lipofuscinoses (NCL) are a group of fatal inherited neurodegenerative diseases in humans distinguished by a common clinical pathology, characterized by the accumulation of storage body material in cells and gross brain atrophy. In this study, metabolic changes in three NCL mouse models were examined looking for pathways correlated with neurodegeneration. Two mouse models; motor neuron degeneration (mnd) mouse and a variant model of late infantile NCL, termed the neuronal ceroid lipofuscinosis (nclf) mouse were investigated experimentally. Both models exhibit a characteristic accumulation of autofluorescent lipopigment in neuronal and non neuronal cells. The NMR profiles derived from extracts of the cortex and cerebellum from mnd and nclf mice were distinguished according to disease/wildtype status. In particular, a perturbation in glutamine and glutamate metabolism, and a decrease in γ-amino butyric acid (GABA) in the cerebellum and cortices of mnd (adolescent mice) and nclf mice relative to wildtype at all ages were detected. Our results were compared to the Cln3 mouse model of NCL. The metabolism of mnd mice resembled older (6 month) Cln3 mice, where the disease is relatively advanced, while the metabolism of nclf mice was more akin to younger (1-2 months) Cln3 mice, where the disease is in its early stages of progression. Overall, our results allowed the identification of metabolic traits common to all NCL subtypes for the three animal models.

  17. EMT nurjas Rate.ee ostuga Elisa kõnekaardiplaani / Gert D. Hankewitz

    Index Scriptorium Estoniae

    Hankewitz, Gert D.

    2006-01-01

    Ilmunud ka: Delovõje Vedomosti 12. apr. lk. 2. Elisa juhatuse esimehe Sami Seppäneni sõnul ostis EMT suhtlusportaali Rate.ee, kuna sai teada, et Elisa ning portaal plaanivad koos uue kõnekaardi turule tuua

  18. Suicide in patients with motor neuron disease

    DEFF Research Database (Denmark)

    Bak, Søren; Stenager, E N; Stenager, Egon

    1994-01-01

    The aim of the present study was to assess, through an epidemiological study, whether suicide risk is increased in patients with motor neuron disease (MND). The study involved 116 patients with MND. In the study period 92 patients died, 47 males and 45 females. No patients committed suicide....... The number of expected suicides was 0.27 for males and 0.12 for females, a total of 0.38. The difference between observed and expected suicides was not statistically significant for males and females....

  19. Viljandi laululava = Viljandi festival arena

    Index Scriptorium Estoniae

    2015-01-01

    Viljandi laululava Talli tänav 2, valminud 2013. Arhitektid Ott Kadarik, Mihkel Tüür, Tanel Trepp (Kadarik Tüür Arhitektid OÜ), insenerid Tõnu Peipman, Viljar Sepp (IB Printsiip OÜ). Eesti Kultuurkapitali Arhitektuuri sihtkapitali aastapreemia 2014

  20. Tummfilmiklassika kohtub maailmamuusikaga / Andreas Sepp

    Index Scriptorium Estoniae

    Sepp, Andreas

    2011-01-01

    Festivalist "Tummfilmid tõstavad häält", mis kestab 19.02.-5.03.2011. Filmi "Inimene filmikaameraga" (Venemaa, 1929) uushelindab Dead Combo, "Noored Kotkad" (Eesti, 1927/2008) Meelis Vind (Eesti) ja Napoleon Maddox (USA), "Berliin, suurlinna sümfoonia" (Saksamaa, 1927) ÖÄK, "Antenn" (Argentina, 2007) Argento Tango Fusion

  1. Saaremaa politseijuht pensionile / Andres Sepp

    Index Scriptorium Estoniae

    Sepp, Andres, 1976-

    2005-01-01

    Kuressaare politseijaoskonna ülemkomissar Ants Ley esitas politseiametile lahkumisavalduse. Väidetavalt on nimetatud ühe võimaliku politseijuhikandidaadina Lääne prefektuuri teenistusosakonna komissari Aare Alliku nime. Lisa: Ants Ley

  2. Sisearhitektuuri uudised / Aino Ingrid Sepp

    Index Scriptorium Estoniae

    Sepp, Aino Ingrid

    2006-01-01

    Keraamiliste plaatide müügisalongi "Interno" uue sisekujunduse autorid Eerik Olle ja Ahti Petersoo. Viking Windowsi peakontori (Jüri Okas) uue sisekujunduse ja "Sämmi grilli" (Toomas Rein) uue sisekujunduse autor Taevo Gans

  3. Quantification of brain metabolites in amyotrophic lateral sclerosis by localized proton magnetic resonance spectroscopy

    DEFF Research Database (Denmark)

    Gredal, O; Rosenbaum, S; Topp, S

    1997-01-01

    We performed proton magnetic resonance spectroscopy (1H-MRS) in patients with motor neuron disease (MND) to determine the absolute in vivo concentrations in the brain of the metabolites N-acetyl aspartate (NAA), choline (Cho), and creatine (Cr/PCr). We examined the spectra acquired from a 20 x 20 x...... subjects. We estimated the concentrations of the metabolites using the water signal as an internal standard. The concentrations of Cho and Cr/PCr in both brain regions, as well as the concentration of NAA in the cerebellum, were unaltered in the MND patients compared with the controls. Only MND patients...... with both upper and lower motor neuron signs had a significantly decreased concentration of NAA (9.13 +/- 0.28 mM, mean +/- SEM) in the primary motor cortex when compared with healthy controls (10.03 +/- 0.22 mM). In conclusion, the slightly decreased concentration of NAA in the primary motor cortex from...

  4. Direct Sensing of Nutrients via a LAT1-like Transporter in Drosophila Insulin-Producing Cells

    Directory of Open Access Journals (Sweden)

    Gérard Manière

    2016-09-01

    Full Text Available Dietary leucine has been suspected to play an important role in insulin release, a hormone that controls satiety and metabolism. The mechanism by which insulin-producing cells (IPCs sense leucine and regulate insulin secretion is still poorly understood. In Drosophila, insulin-like peptides (DILP2 and DILP5 are produced by brain IPCs and are released in the hemolymph after leucine ingestion. Using Ca2+-imaging and ex vivo cultured larval brains, we demonstrate that IPCs can directly sense extracellular leucine levels via minidiscs (MND, a leucine transporter. MND knockdown in IPCs abolished leucine-dependent changes, including loss of DILP2 and DILP5 in IPC bodies, consistent with the idea that MND is necessary for leucine-dependent DILP release. This, in turn, leads to a strong increase in hemolymph sugar levels and reduced growth. GDH knockdown in IPCs also reduced leucine-dependent DILP release, suggesting that nutrient sensing is coupled to the glutamate dehydrogenase pathway.

  5. Finger extension weakness and downbeat nystagmus motor neuron disease syndrome: A novel motor neuron disorder?

    Science.gov (United States)

    Delva, Aline; Thakore, Nimish; Pioro, Erik P; Poesen, Koen; Saunders-Pullman, Rachel; Meijer, Inge A; Rucker, Janet C; Kissel, John T; Van Damme, Philip

    2017-12-01

    Disturbances of eye movements are infrequently encountered in motor neuron diseases (MNDs) or motor neuropathies, and there is no known syndrome that combines progressive muscle weakness with downbeat nystagmus. To describe the core clinical features of a syndrome of MND associated with downbeat nystagmus, clinical features were collected from 6 patients. All patients had slowly progressive muscle weakness and wasting in combination with downbeat nystagmus, which was clinically most obvious in downward and lateral gaze. Onset was in the second to fourth decade with finger extension weakness, progressing to other distal and sometimes more proximal muscles. Visual complaints were not always present. Electrodiagnostic testing showed signs of regional motor axonal loss in all patients. The etiology of this syndrome remains elusive. Because finger extension weakness and downbeat nystagmus are the discriminating clinical features of this MND, we propose the name FEWDON-MND syndrome. Muscle Nerve 56: 1164-1168, 2017. © 2017 The Authors Muscle & Nerve Published by Wiley Periodicals, Inc.

  6. Efficacy of kinesiology tape versus postural correction exercises on neck disability and axioscapular muscles fatigue in mechanical neck dysfunction: A randomized blinded clinical trial.

    Science.gov (United States)

    El-Abd, Aliaa M; Ibrahim, Abeer R; El-Hafez, Haytham M

    2017-04-01

    Mechanical neck dysfunction (MND), with axioscapular muscles fatigue, is highly prevalent worldwide. While postural correction is commonly used for its treatment, efficacy of kinesiology tape (KT) has received considerable attention. To determine the effectiveness of KT versus correction exercises on neck disability, and axioscapular muscles fatigue in MND patients. 46 MND patients were randomly assigned into 1 of 2 groups receiving 4 weeks treatment of either KT or correction exercises. Neck disability and axioscapular muscles fatigue as median frequency of electromyography (EMG-MF) were measured pre and post treatment. Group-by-time interaction was not significant in the multivariable test. Post hoc tests revealed that KT produced more disability reduction than the postural exercises. However, there was no significant interaction for EMG-MF. KT has been found to be more effective than postural exercises to reduce neck disability. However, both modalities have similar effects to reduce axioscapular muscles fatigue. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. Mälestiste vastu ei sõdita / Mart Port

    Index Scriptorium Estoniae

    Port, Mart, 1922-2012

    2004-01-01

    Sõjaohvrite mälestamisest. Autori arvates sobib eesti leinajaid ühendavat ülesannet suurepäraselt täitma Maarjamäe memoriaal, kui see lõpetataks ja korrastataks. Kommenteerivad: Urmas Reinsalu, Evelyn Sepp, Paul-Eerik Rummo, Trivimi Velliste

  8. Lõuka tuuliku restaureerimine / Dan Lukas

    Index Scriptorium Estoniae

    Lukas, Dan

    2005-01-01

    Hiiumaal Pühalepa vallas Vahtrepa külas Lõuka talu maadel asuva pukktuuliku ajaloost, restaureerimise käigust. Teostus: Dan Lukas. Muinsuskaitseline järelevalve: Tõnu Sepp, tema kommentaar. Ill.:pukktuuliku lõiked ja korruste plaanid, 7 värv. fotot

  9. Pärnu uue kunsti muuseumis on näitus "Kümme aastat moodsat kunsti Pärnus varakapitalistliku Eesti tingimustes"

    Index Scriptorium Estoniae

    2003-01-01

    Osalevad Peeter Allik, Mila Balti, Chintis, Margit Joonas, Toomas Kuusing, Hannes Paldrok, Meeland Sepp, Inge Ting, Taje Tross, Andrus Joonas, Bille Tuul, Mariliis Beilmann, Olle Meyer, Sorge, rühmitus Non Grata, Asta Isak, Marianne Männi, Ville-Karel Viirelaid

  10. Impaired Homocysteine Transmethylation and Protein-Methyltransferase Activity Reduce Expression of Selenoprotein P: Implications for Obesity and Metabolic Syndrome

    Science.gov (United States)

    Obesity causes Metabolic Syndrome and Type-II Diabetes, disrupting hepatic function, methionine (Met)/homocysteine (Hcy) transmethylation and methyltransferase (PRMT) activities. Selenoprotein P (SEPP1), exported from the liver, is the predominate form of plasma selenium (Se) and the physiological S...

  11. 1 küsimus noorele juhile : Mis teha, kui kopp on ees - kuidas sa stressist jagu saad? / Riho Jürvetson, Merit Miller, Krister Rekkaro ... [jt.

    Index Scriptorium Estoniae

    2009-01-01

    Küsimusele vastavad EMT erakliendi osakonna juhataja Riho Jürvetson, KPMG Baltics müügijuht Merit Miller, ArtPrint juht Krister Rekkaro, Dateli juhatuse liige Triin Sepp, Media House projektijuht Tanel Tarkmees, Ober-Haus Kinnisvara tegevjuht Katrin Klein-Näppi

  12. Therapeutical aspect of trichomoniasis

    Directory of Open Access Journals (Sweden)

    Vukićević Jelica

    2003-01-01

    Full Text Available Trichomoniasis is frequent, parasitic and sexually transmitted infection of genitourinary tract. It is treated by metronidazole (5-nitroimidazole according to protocol recommended by Center for Disease Control (CDC formerly called: Communicable Disease Center [19]. The resistance of Trichomonas vaginalis (TV strains to metronidazole (MND was described in USA in 1960, and later on in many European countries [8, 9, 10, 11, 12, 13]. In these cases, due to persistent trichomonas infection, it is necessary to repeat MND treatment with moderate modification of dose and/or length of its application. Nevertheless, oncogenic and toxic effects of MND have to be taken into consideration. OBJECT The aim of this study was to investigate and analyze the incidence of TV in STD and lower susceptibility of certain TV strains to MND were analyzed. MATERIAL AND METHODS In three-year period (1999-2001 612 patients (244 females and 368 males suspected of STD were examined clinically and microbiologically at the Institute of Dermatovenereology in Belgrade. The patients detected for TV were treated according to CDC protocol. The affected were considered cured if there was no manifest clinical infection, and no TV verified by microbiological test. Results TV was isolated in 216 patients (35.29 % of all subjects. Trichomonas infection was found in 90 (36.88 % out of 244 tested females and in 126 (32.34 % of 368 males. Clinically manifested infection, with extensive urethral and vaginal secretion, was recorded in 161 patients, while the asymptomatic form was found in 55 subjects. This result indicates the predominance of manifested trichomonas infections (75.54 % of cases. The difference of distribution of clinical forms of trichomoniasis, in relation to sex, was not statistically significant (c2=0.854; p>0.05. The patients with verified trichomonas infection were treated by metronidazole according to CDC protocol. The recommended therapeutical scheme consisted of three

  13. Ülemiste kaubanduskeskus = Ülemiste shopping center / Priit Põldme ; kommenteerinud Linda Madalik

    Index Scriptorium Estoniae

    Põldme, Priit, 1971-

    2015-01-01

    Ülemiste kaubanduskeskus Tallinnas Suur-Sõjamäe 4. Sisekujunduse autorid Priit Põldme, Reet Sepp (sisearhitektuuribüroo Joonprojekt); arhitektid Einar Aakeroy (AMB Arkitekter), Lauri Laisaar, Ingel Sirkel-Suviste, Jaanika Oks, Katrin Kõlu (Novarc Group AS). Lühidalt Priit Põldmest ja Reet Sepast

  14. Association between Polymorphisms in Glutathione Peroxidase and Selenoprotein P Genes, Glutathione Peroxidase Activity, HRT Use and Breast Cancer Risk

    DEFF Research Database (Denmark)

    Méplan, Catherine; Dragsted, Lars Ove; Ravn-Haren, Gitte

    2013-01-01

    Breast cancer (BC) is one of the most common cancers in women. Evidence suggests that genetic variation in antioxidant enzymes could influence BC risk, but to date the relationship between selenoproteins and BC risk remains unclear. In this report, a study population including 975 Danish cases...... and 975 controls matched for age and hormone replacement therapy (HRT) use was genotyped for five functional single nucleotide polymorphisms (SNPs) in SEPP1, GPX1, GPX4 and the antioxidant enzyme SOD2 genes. The influence of genetic polymorphisms on breast cancer risk was assessed using conditional...... logistic regression. Additionally pre-diagnosis erythrocyte GPx (eGPx) activity was measured in a sub-group of the population. A 60% reduction in risk of developing overall BC and ductal BC was observed in women who were homozygous Thr carriers for SEPP1 rs3877899. Additionally, Leu carriers for GPX1 Pro...

  15. Tudengite küsitlus: kas Aruküla säilitab identiteedi või muutub Tallinna magalaks / Ere Uibo

    Index Scriptorium Estoniae

    Uibo, Ere

    2017-01-01

    Aruküla elaniku Cristina Kaska eestvedamisel tegid Tallinna Ülikooli tudengid Aruküla elukeskkonna teemal küsitluse ja uurimistöö. Cristina Kaska õpib Tallinna Ülikoolis magistriõppes haridustehnoloogiat, uurimisgrupis osalesid ka Marika Kundla, Elle Altmets, Kadi Kasepõld ja Heret Annus. Uuringuga selgitati välja elanike rahulolu Aruküla heakorra, korteriühistute ja vallavalitsuse tööga ning nende endi valmisolek panustada heakorra parandamisse

  16. Prediction of cleavage crack propagation and arrest in a nuclear pressure vessel steel (16MND5) under thermal shock

    International Nuclear Information System (INIS)

    Yang, Xiaoyu

    2015-01-01

    The purpose of this PhD study is to predict the propagation and arrest of cleavage cracks in a French PWR vessel steel (16MND5). This is accomplished through use of a local criterion based on the critical stress calculated ahead of crack tip. Previous work has shown that fracture mechanism was cleavage associated with the ductile shear zone between the different planes of cracking. Thus, the critical stress at crack tip depends on stain rate. This thesis consists of numerical optimization, identification and validation of a local criterion based on experiments which have complex thermomechanical loads. The criterion accounts for various crack paths, deepening the knowledge about micro mechanisms during crack propagation in order to justify the established criterion. Criterion identification was carried out by using numerical simulations of tension tests performed on CT (Compact Tension) specimens at four different temperatures (-150 C, -125 C, -100 C and -75 C). The eXtended Finite Element Method (X-FEM) was used in CAST3M FE software to model dynamic crack propagation and arrest. The analysis results in 2D and 3D showed that the critical stress at crack tip increased with the inelastic strain rate. Therefore, a criterion based on the critical stress was established. An analytical model was developed to justify the identified criterion. The critical stress given by the local criterion was considered as the sum of the critical cleavage stress and the stress generated by the deformation of ligaments behind the crack tip. In order to quantify this phenomenon, measurements of ligaments' characteristics have been performed on fracture surfaces and on cross-sections of the specimens. The stress profile of the crack lips generated by ligaments was calculated by modeling of multi-cracks on specimen's cross-section. The contribution of stress generated by ligaments to the critical stress at crack tip was obtained with this method, and then the analytical model of

  17. Poola pole Ignalina plaane lukku löönud / Piotr Wozniak ; interv. Raimo Poom

    Index Scriptorium Estoniae

    Wozniak, Piotr

    2007-01-01

    Äsja laialisaadetud Poola valitsuse majandusministri sõnul soovib Poola olla Ignalina tuumaelektrijaama projektis aktiivne investor, st Poola soovib teatud osa selle kavandatavast võimsusest, minimaalselt 1000 MW. Meelis Atonen, Villu Reiljan ja Evelyn Sepp vastavad küsimusele, kas Ignalina suudab põlevkivienergiat asendada

  18. Kolm tähelepanuväärset bibliograafiat / Tiina Ritson

    Index Scriptorium Estoniae

    Ritson, Tiina, 1955-

    2011-01-01

    Arvustus: Uku Masing 100 : bibliograafia 1923-2009 / koost. Anneli Sepp. Tartu : Ilmamaa, 2010. Voldemar Panso bibliograafia / koost. Katre Riisalu, Eha Garšnek, Mari Sibul. Tallinn : Eesti Draamateater, 2010. Pilv, Aare. Juhan Viidingu ja Jüri Üdi bibliograafia // Juhan Viiding, eesti luuletaja. Tartu, 2010.

  19. Pärnus tähistatakse moodsa kunsti 10. aastapäeva

    Index Scriptorium Estoniae

    2003-01-01

    Ülevaatenäitus Pärnu Uue Kunsti Muuseumis. Näitusel osalevad Peeter Mudist, Mila Balti, Chintis, Margit Joonas, Toomas Kuusing, Hannes Paldrok, Meeland Sepp, Inge Ting, Taje Tross, Andrus Joonas, Bille Tuul, Marliis Beilmann, Olle Meyes, Sorge, Non Grata, Asta Isak, Marianne Männi

  20. Pensionitõus ja pangad / Marika Tuus

    Index Scriptorium Estoniae

    Tuus, Marika, 1951-

    2006-01-01

    Ilmunud ka: Videvik 16. märts lk. 3, Vali Uudised 17. märts lk. 2, Meie Maa 18. märts lk. 2, Virumaa Teataja, Pärnu Postimees, Harjumaa, Põhjarannik, Severnoje Poberezhje 21. märts lk. 11,19,7,2,5, Nädaline 28. märts lk. 3. 1. apr. viiakse läbi teine uue valitsuse erakonnaline pensionitõus. Pangad on laenuandmise vanusepiirangut kergitanud 10 aasta võrra

  1. Appi, pea lõhub / Marika Makarova

    Index Scriptorium Estoniae

    Makarova, Marika

    2010-01-01

    Vestlusest Ida-Tallinna Keskhaigla neuroloogiaosakonna juhataja ja peavalukeskuse rajaja dr Toomas Toomsooga ning Aurea ajurveeda- ja massaažikeskuse ajurveedaarsti Aleksandr Dreljoviga peavalust: peavalu ravi india ajurveeda seisukohalt, läänemeditsiini peavalu tüübid ning nende ravi jne

  2. Siledaks ja saledaks skalpellita / Marika Makarova

    Index Scriptorium Estoniae

    Makarova, Marika

    2013-01-01

    Eestis enamlevinud protsetuuridest kortsude silumiseks, naha noorendamiseks, keha salendamiseks ja juuste kohendamiseks: botox-süstid, hüaloroonhappesüstid, fotonoorendus, lasernoorendus, velashape tselluliidihooldus, kavitatsioon, tahe magic botox vananemisvastane juuksehooldus

  3. Reis kosmosesse : [Floating-kambrist] / Marika Makarova

    Index Scriptorium Estoniae

    Makarova, Marika

    2011-01-01

    Ameerika psühholoogi John C. Lilly poolt kasutusele võetud Floating-kambrist ehk hõljumisvannist, mis aeglustab ajulaineid ning seeläbi aitab vähendada lihaspinget, stressi, ärevust, peavalusid, vererõhku ning parandada und, selgroo- ja kaelavigastusi, suurendada loovust ja heaolu jne

  4. Liival etenduvad vangide elulood / Marika Raiski

    Index Scriptorium Estoniae

    Raiski, Marika

    2000-01-01

    Merle Karusoo 12 vangi elulugu käsitlevast dokumentaallavastusest "Save Our Souls", mis tuleb ettekandele 31. mail Tallinnas Liiva keskuses. Etenduses osalevad Vene Draamateatri ja Narva Teatri Ilmarine näitlejad. Eestvedajaks on VAT Teater

  5. "Ravimiohutus - rahva tervise kaitseks" / Marika Gordon

    Index Scriptorium Estoniae

    Gordon, Marika

    2010-01-01

    Ajakirja “Apteeker” ja Eesti Akadeemilise Farmaatsia Seltsi kevadkonverentsi ettekandeid kommenteerivad MEDA Pharma SIA Eesti juhataja Anu Adermann, Apteekide infotehnoloogia OÜ juhataja Siim Uibokand, Pärnu Lõvi apteegi juhataja Kärt Kambla ja Eesti Haigekassa ravimiosakonna peaspetsialist Erki Laidmäe

  6. Alaealise õigus abordile / Marika Žmenja

    Index Scriptorium Estoniae

    Žmenja, Marika

    2014-01-01

    1. jaanuaril 2009 jõustusid raseduse katkestamise ja steriliseerimise seaduse muudatused, mille järgi alaealise raseduse katkestamiseks on vaja lisaks tema enda sooviavaldusele saada ka eestkostja nõusolek või kohtu luba. Alaealise õigusest eraelu kaitsele inimõiguste ja põhivabaduste kaitse konventsiooni ja Euroopa Kohtu praktika alusel

  7. Tõde pensionide kojukande kohta / Marika Tuus

    Index Scriptorium Estoniae

    Tuus, Marika, 1951-

    2008-01-01

    Pensionide kojukande muudatustest ning vastuseks 28. oktoobri ajalehes ilmunud Heljo Pikhofi artiklile "Pensioniraha jõuab igaüheni". Ilmunud ka Harju Ekspress 7. nov. 2008, lk. 9 ; Põhjarannik 6. nov. 2008, lk. 2 ; Võrumaa Teataja 8. nov. 2008, lk. 2 ; Pärnu Postimees 6. nov. 2008, lk. 11 ; Vooremaa 13. nov. 2008, lk. 2 ; Virumaa Teataja 21. nov. 2008, lk. 11, pealkiri kujul: veel pensionide kojukandest ; Sõnumitooja 12. nov. 2008, lk. 2

  8. Voltage-Gated Potassium Channel Antibodies in Slow-Progression Motor Neuron Disease.

    Science.gov (United States)

    Godani, Massimiliano; Zoccarato, Marco; Beronio, Alessandro; Zuliani, Luigi; Benedetti, Luana; Giometto, Bruno; Del Sette, Massimo; Raggio, Elisa; Baldi, Roberta; Vincent, Angela

    2017-01-01

    The spectrum of autoimmune neurological diseases associated with voltage-gated potassium channel (VGKC)-complex antibodies (Abs) ranges from peripheral nerve disorders to limbic encephalitis. Recently, low titers of VGKC-complex Abs have also been reported in neurodegenerative disorders, but their clinical relevance is unknown. The aim of the study was to explore the prevalence of VGKC-complex Abs in slow-progression motor neuron disease (MND). We compared 11 patients affected by slow-progression MND with 9 patients presenting typical progression illness. Sera were tested for VGKC-complex Abs by radioimmunoassay. The distribution of VGKC-complex Abs was analyzed with the Mann-Whitney U test. The statistical analysis showed a significant difference between the mean values in the study and control groups. A case with long-survival MND harboring VGKC-complex Abs and treated with intravenous immunoglobulins is described. Although VGKC-complex Abs are not likely to be pathogenic, these results could reflect the coexistence of an immunological activation in patients with slow disease progression. © 2016 S. Karger AG, Basel.

  9. Attitudes towards euthanasia and physician-assisted suicide among Pakistani and Indian doctors: A survey

    Directory of Open Access Journals (Sweden)

    Syed Qamar Abbas

    2008-01-01

    Full Text Available Aim: This study attempts to assess the attitude of Pakistani and Indian doctors to euthanasia and physician-assisted suicide. Methods: We used a questionnaire survey that included one case history of a patient with cancer and another of one suffering from motor neurone disease (MND. Results: Fifty-two of 100 doctors from Pakistan returned the completed questionnaires. Eight of the 52 (15.3% doctors agreed with the concept of euthanasia being an acceptable option for the patient with MND. Six of the 52 (11.5% supported a similar approach for the cancer patient. From India, 60/100 doctors returned the completed questionnaires. Sixteen of the 60 (26.6% doctors supported euthanasia as an option for the patient with MND whereas 15 (25% supported a similar option for the cancer patient. Conclusion: We conclude that only a minority of the doctors support euthanasia. This group belongs to a younger age group. In Pakistan, they were more likely to be males. The religion of the doctors did not appear to be a determining factor.

  10. A self-care, problem-solving and mindfulness intervention for informal caregivers of people with motor neurone disease: A pilot study.

    Science.gov (United States)

    Ugalde, Anna; Mathers, Susan; Hennessy Anderson, Nicole; Hudson, Peter; Orellana, Liliana; Gluyas, Cathy

    2018-04-01

    Informal caregivers of people with motor neurone disease (MND) take on an extensive role. Caregivers are at increased risk of experiencing psychological distress and burden, yet, there is a lack of intervention programmes to support them. The aim of this study was to investigate the feasibility and acceptability of a therapeutic group intervention promoting self-care, problem-solving and mindfulness to informal caregivers of people with MND. Pilot study that utilised a one-arm pre- and post-design. Acceptability of the intervention was assessed 2 weeks post intervention with a questionnaire designed specifically for this study. Feasibility was assessed with consent, adherence and reasons for non-participation, refusal and attrition. Participants completed baseline and follow-up (6-week post intervention) questionnaires for psychological morbidity, burden, problem-solving, mindfulness and preparedness. Settings/participants: Caregivers of people with a diagnosis of MND within the past 12 months who were 18 years or older; who could speak, read and write in English and who were attending a progressive neurological diseases clinic were eligible. A total of 13 caregivers participated in one of three group intervention sessions which were focused on self-care, problem-solving and mindfulness. The intervention appeared to be feasible and acceptable. All participants stated that they would recommend the intervention to others. The group format appeared to be highly valued. There was no significant change in measures between pre-intervention and 6 weeks post intervention. This pilot serves as an initial step for examining interventions for MND caregivers, with the hope of identifying effective, efficient and sustainable strategies to best support this group.

  11. Predictive value of general movements' quality in low-risk infants for minor neurological dysfunction and behavioural problems at preschool age.

    Science.gov (United States)

    Bennema, Anne N; Schendelaar, Pamela; Seggers, Jorien; Haadsma, Maaike L; Heineman, Maas Jan; Hadders-Algra, Mijna

    2016-03-01

    General movement (GM) assessment is a well-established tool to predict cerebral palsy in high-risk infants. Little is known on the predictive value of GM assessment in low-risk populations. To assess the predictive value of GM quality in early infancy for the development of the clinically relevant form of minor neurological dysfunction (complex MND) and behavioral problems at preschool age. Prospective cohort study. A total of 216 members of the prospective Groningen Assisted Reproductive Techniques (ART) cohort study were included in this study. ART did not affect neurodevelopmental outcome of these relatively low-risk infants born to subfertile parents. GM quality was determined at 2 weeks and 3 months. At 18 months and 4 years, the Hempel neurological examination was used to assess MND. At 4 years, parents completed the Child Behavior Checklist; this resulted in the total problem score (TPS), internalizing problem score (IPS), and externalizing problem score (EPS). Predictive values of definitely (DA) and mildly (MA) abnormal GMs were calculated. DA GMs at 2 weeks were associated with complex MND at 18 months and atypical TPS and IPS at 4 years (all ppredictive value of DA GMs at 2 weeks were rather low (13%-60%); specificity and negative predictive value were excellent (92%-99%). DA GMs at 3 months occurred too infrequently to calculate prediction. MA GMs were not associated with outcome. GM quality as a single predictor for complex MND and behavioral problems at preschool age has limited clinical value in children at low risk for developmental disorders. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  12. Grand Prix' võitis reklaamfilmistuudio Division / Mait Laas, Jaak Lõhmus, Ants Vist...[jt.] ; interv. Tiiu Leis

    Index Scriptorium Estoniae

    1998-01-01

    Pärnu filmipäevadel 'Do Re Vi' võitis Grand Prix ehk skulptuuri 'Oskar & Ella' reklaamistuudio 'Division', kullatud videokassetid said 'Polarfilm' (dok. film), Martin Pedanik (video) ja Edith Sepp ('Tingimustega Tallinnas'); osalejate M. Laasi, J. Lõhmuse, A. Visti ja I. Raagi kommentaare ürituse kohta;

  13. Mõisamuinasjutt / Helena Piip

    Index Scriptorium Estoniae

    Piip, Helena

    2004-01-01

    Jõuluaja veetmise võimalustest Palmse mõisas. Mõisarahvas kannab Mare Raidma kavandite järgi valmistatud 19. sajandi rõivaid. Keldri veini-, jahisaali jm. ruumide sisustuse on kavandanud Kalju Kivi, "Isabella" kohviku on kujundanud Leila Pärtelpoeg. Sepikojas (sepp Kaupo Kangur) saab õnne valada ja rauda taguda

  14. Numerical modelling of Charpy-V notch test by local approach to fracture. Application to an A508 steel in the ductile-brittle transition range; Modelisation de l'essai Charpy par l'approche locale de la rupture. Application au cas de l'acier 16MND5 dans le domaine de transition

    Energy Technology Data Exchange (ETDEWEB)

    Tanguy, B

    2001-07-15

    Ferritic steels present a transition of the rupture mode which goes progressively of a brittle rupture (cleavage) to a ductile rupture when the temperature increases. The following of the difference of the transition temperature of the PWR vessel steel by the establishment of toughness curves makes of the Charpy test an integrating part of the monitoring of the French PWR reactors. In spite of the advantages which are adapted to it in particular its cost, the Charpy test does not allow to obtain directly a variable which characterizes a crack propagation resistance as for instance the toughness used for qualifying the mechanical integrity of a structure. This work deals with the establishment of the through impact strength-toughness in the transition range of the vessel steel: 16MND5 from a non-empirical approach based on the local approach of the rupture. The brittle rupture is described by the Beremin model (1983), which allows to describe the dispersion inherent in this rupture mode. The description of the brittle fissure is carried out by the GTN model (1984) and by the Rousselier model (1986). This last model has been modified in order to obtain a realistic description of the brittle damage in the case of fast solicitations and of local heating. The method proposed to determine the parameters of the damage models depends only of tests on notched specimens and of the inclusion data of the material. The behaviour is described by an original formulation parametrized in temperature which allows to describe all the tests carried out in this study. Before using this methodology, an experimental study of the behaviour and of the rupture modes of the steel 16MND5 has been carried out. From the toughness tests carried out in quasi-static and dynamical conditions, it has been revealed that this steel does not present important unwedging of its toughness curve due to the velocity effect. In the transition range, local heating of about 150 C have been measured in the root

  15. Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women

    International Nuclear Information System (INIS)

    Dyke, A. L. V.

    2009-01-01

    In a population-based case-control study, we explored the associations between 42 polymorphisms in seven genes in this region and non-small cell lung cancer (NSCLC) risk among Caucasian (364 cases; 380 controls) and African American (95 cases; 103 controls) women. Two TERT region SNPs, rs2075786 and rs2853677, conferred an increased risk of developing NSCLC, especially among African American women, and TERT-rs2735940 was associated with a decreased risk of lung cancer among African Americans. Five of the 20 GHR polymorphisms and SEPP1-rs6413428 were associated with a marginally increased risk of NSCLC among Caucasians. Random forest analysis reinforced the importance of GHR among Caucasians and identified AMACR, TERT, and GHR among African Americans, which were also significant using gene-based risk scores. Smoking-SNP interactions were explored, and haplotype in TERT and GHR associated with NSCLC risk were identified. The roles of TERT, GHR, AMACR and SEPP1 genes in lung carcinogenesis warrant further exploration

  16. Molecular nonlinear dynamics and protein thermal uncertainty quantification

    Science.gov (United States)

    Xia, Kelin; Wei, Guo-Wei

    2014-01-01

    This work introduces molecular nonlinear dynamics (MND) as a new approach for describing protein folding and aggregation. By using a mode system, we show that the MND of disordered proteins is chaotic while that of folded proteins exhibits intrinsically low dimensional manifolds (ILDMs). The stability of ILDMs is found to strongly correlate with protein energies. We propose a novel method for protein thermal uncertainty quantification based on persistently invariant ILDMs. Extensive comparison with experimental data and the state-of-the-art methods in the field validate the proposed new method for protein B-factor prediction. PMID:24697365

  17. 运动神经元病%Motor Neuron Disease

    Institute of Scientific and Technical Information of China (English)

    蒋雨平

    2014-01-01

    Motor neuron disease (MND) represents a group of sporadic or genetic neurodegenerative diseases which principally affect the motor neurons and result in progressive paralysis and death. The epidemiology, genetics, clinical manifestation, diagnostic criteria of MND were reviewed.%运动神经元病是一组散发或遗传的神经变性病。主要累及运动神经元,病程进展而死亡。文中就其临床表现和诊断标准、流行病学和遗传学进行综述。

  18. Tubin: The Parson of Reigi / Robert Layton

    Index Scriptorium Estoniae

    Layton, Robert

    1993-01-01

    Uuest heliplaadist "Tubin: The Parson of Reigi. Teo Maiste, Marika Eensalu, Ivo Kuusk, Annika Tõnuri, Urve Tauts, Leili Tammel, Tiit Tralla, Arvo Laid. Estonia Opera Company / Paul Mägi; Requiem for Fallen Soldiers. Urve Tauts, Talevaldis Deksnis, Urmas Leiten, Rein Tiido, Rein Roos. Estonian National Male Choir / Eri Klas. Ondine CD ODE 783-2 (2 discs: 116 min.). Recorded in association with the Estonian Cultural Foundation. Requiem - comparative version: Lund. Choral Soc., Järvi (9/88) CD 297

  19. Kolmene ülikool esitles professoreid ja kirjanduspreemia laureaate

    Index Scriptorium Estoniae

    2008-01-01

    Tallinna Ülikool esitles 3. aastapäeva aktusel aasta jooksul professoreiks valituid: Lorenzo Cañás Bottos, Jyrki Käkönen, Aaro Toomela, Airi Värnik, Marika Mägi, Priit Reiska, Eve Kikas ja Karsten Brüggemann. Selgusid ka tänavused Tallinna Ülikooli kirjanduspreemia laureaadid. Algupärase ilukirjanduse vallas pälvis auhinna romanist, luuletaja ja tõlkija, doktorant Maarja Kangro, tõlkepreemia sai kirjanik ja tõlkija Arvo Valton

  20. The tyger = Tiiger : [luuletus] / William Blake

    Index Scriptorium Estoniae

    Blake, William

    1997-01-01

    W. Blake'i luuletus 'Tiiger' originaalis ja seitsmes eri tõlkes, tõlkijateks Ilmar Laaban, Toivo Pilli, Rein Sepp, Ene-Reet Soovik, Jüri Talvet, Udo Uibo ja Märt Väljataga.Vt. ka Märt Väljataga artiklit 'Luule tõlkimine ja 'Tiiger'' Vikerkaares 1997, nr. 6

  1. Paet: suure kindlusega võib öelda, et eestlased on elus / Ilmar Kahro

    Index Scriptorium Estoniae

    Kahro, Ilmar

    2011-01-01

    Vahendatud intervjuu välisminister Urmas Paetiga, kes märgib, et viimases Liibanonis röövitud eestlaste videos pöörduvad nad sugulaste poole. Eesti juhtiv riigiprokurör Heili Sepp oli 10.-13. juulini lähetuses Liibanonis, kus oli kohtunud kõrgete kohalike ametnikega

  2. Mida paljastas nutitelefoni lõhkumine? / Villu Zirnask

    Index Scriptorium Estoniae

    Zirnask, Villu, 1966-

    2011-01-01

    Soome majandusuuringute instituudi teadurid ja elektroonikainsenerid Jyrki Ali-Yrkkö, Petri Rouvinen, Timo Seppälä ja Pekka Ylä-Anttila analüüsisid uuringus "Who Captures Value in Global Supply Chains? Case Nokia N95 Smartphone" nutitelefoni hinnakujundust. Detailihindade, koostehindade ja lõpphinna suhe. Diagramm.

  3. Numerical modelling of Charpy-V notch test by local approach to fracture. Application to an A508 steel in the ductile-brittle transition range; Modelisation de l'essai Charpy par l'approche locale de la rupture. Application au cas de l'acier 16MND5 dans le domaine de transition

    Energy Technology Data Exchange (ETDEWEB)

    Tanguy, B

    2001-07-15

    Ferritic steels present a transition of the rupture mode which goes progressively of a brittle rupture (cleavage) to a ductile rupture when the temperature increases. The following of the difference of the transition temperature of the PWR vessel steel by the establishment of toughness curves makes of the Charpy test an integrating part of the monitoring of the French PWR reactors. In spite of the advantages which are adapted to it in particular its cost, the Charpy test does not allow to obtain directly a variable which characterizes a crack propagation resistance as for instance the toughness used for qualifying the mechanical integrity of a structure. This work deals with the establishment of the through impact strength-toughness in the transition range of the vessel steel: 16MND5 from a non-empirical approach based on the local approach of the rupture. The brittle rupture is described by the Beremin model (1983), which allows to describe the dispersion inherent in this rupture mode. The description of the brittle fissure is carried out by the GTN model (1984) and by the Rousselier model (1986). This last model has been modified in order to obtain a realistic description of the brittle damage in the case of fast solicitations and of local heating. The method proposed to determine the parameters of the damage models depends only of tests on notched specimens and of the inclusion data of the material. The behaviour is described by an original formulation parametrized in temperature which allows to describe all the tests carried out in this study. Before using this methodology, an experimental study of the behaviour and of the rupture modes of the steel 16MND5 has been carried out. From the toughness tests carried out in quasi-static and dynamical conditions, it has been revealed that this steel does not present important unwedging of its toughness curve due to the velocity effect. In the transition range, local heating of about 150 C have been measured in the root

  4. Ristipoja mälestusi / Reino Sepp

    Index Scriptorium Estoniae

    Sepp, Reino

    2005-01-01

    Reino Sepa mälestusi Johannes Aavikust. Katkendid on võetud tema varem ilmunud artiklist "Mälestusi ja mõteid Johannes Aavikust", mis ilmus 1991. aastal ajalehe Meie Maa väljaandes "Minu Saaremaa"

  5. Auhinnatud Hollandi saatkond Berliinis / Aino Sepp

    Index Scriptorium Estoniae

    Sepp, Aino

    2005-01-01

    Hollandi saatkonna hoonest - arhitektid Rem Koolhaas (sünd. 1944) ja Ellen van Loon arhitektuuribüroost OMA (Ofice for Metropolitan Architecture) - Berliinis. Väljaspoolt viiekordsena mõjuvas majas on kaheksa tasandit. Hoone võitis 2005. a. Mies van der Rohe nimelise arhitektuuripreemia. Rem Koolhaasist. 12 värv. ill

  6. Pokoja net kak net / Evelyn Sepp

    Index Scriptorium Estoniae

    Sepp, Evelyn, 1972-

    2007-01-01

    Riigikogu liige loodab, et peale valimisi kaitseminister Jürgen Ligi poolt kokku kutsutud sõjahaudade komisjon ei kiirusta enam oma otsuste tegemisega, millega võiks kaasneda pronkssõduri teisaldamine

  7. Why don't they accept non-invasive ventilation?: insight into the interpersonal perspectives of patients with motor neurone disease.

    Science.gov (United States)

    Ando, Hikari; Williams, Carl; Angus, Robert M; Thornton, Everard W; Chakrabarti, Biswajit; Cousins, Rosanna; Piggin, Lucy H; Young, Carolyn A

    2015-05-01

    Although non-invasive ventilation (NIV) can benefit survival and quality of life, it is rejected by a substantial proportion of people with motor neurone disease (MND). The aim of this study was to understand why some MND patients decline or withdraw from NIV. Nine patients with MND (male = 7, mean age = 67 years) participated in this study. These patients, from a cohort of 35 patients who were offered NIV treatment to support respiratory muscle weakness, did not participate in NIV treatment when it was clinically appropriate. Semi-structured interviews and interpretative phenomenological analysis (IPA) were employed to explore these patient's experience of MND and their thoughts and understanding of NIV treatment. Using IPA, four themes were identified: preservation of the self, negative perceptions of NIV, negative experience with health care services, and not needing NIV. Further analysis identified the fundamental issue to be the maintenance of perceived self, which was interpreted to consist of the sense of autonomy, dignity, and quality of life. The findings indicate psychological reasons for disengagement with NIV. The threat to the self, the sense of loss of control, and negative views of NIV resulting from anxiety were more important to these patients than prolonging life in its current form. These findings suggest the importance of understanding the psychological dimension involved in decision-making regarding uptake of NIV and a need for sensitive holistic evaluation if NIV is declined. Statement of contribution What is already known on this subject? Non-invasive ventilation is widely used as an effective symptomatic therapy in MND, yet about a third of patients decline the treatment. Psychological disturbance generated by NIV use leads to negative experiences of the treatment. Decision-making about treatment potentials is complex and unique to each individual affected by perceived impact of disease. What does this study add? A decision concerning

  8. Kitsas silmaring on nuhtluseks endale, teistele, kogu riigile / Raivo Juurak, Kaiko Lippur

    Index Scriptorium Estoniae

    Juurak, Raivo, 1949-

    2014-01-01

    Westholmi Gümnaasiumi riigikaitseõpetuse õppetooli juhataja Kaiko Lippur selgitab, et riigikaitseõpetus on eelkõige õpilaste silmaringi laiendamiseks. Küsimusele, mida riigikaitseõpetus annab, vastavad Westholmi gümnaasiumi õpilased Jaan Kaarel Sepp, Marie Helen Lisete Kikas ja Kaisa-Mai Kallaste ning Rocca al Mare kooli lapsevanem Katariina L. Martens

  9. Põimunud ajastud vanalinnakodus / Helle Neemre

    Index Scriptorium Estoniae

    Neemre, Helle

    1998-01-01

    Kaasajastatud vanalinnakorter Väike-Karja tänavas. Muljeid ja meenutusi tehtust sisekujundaja Helle Neemrelt. Pildiallkirjad - Jüri Kuuskemaa. Korterist võib leida Hansa-aegseid detaile, regionalistlikku laadi, moodsaid mugavusi kaasaegses kujunduses. Sepised (kardinapuud, trepikäsipuu, kaminariistad, -rest) - sepp Raivo Uus. Paekivist detailid restaureeris KAR Grupp. Diivan ja laud - Mang.

  10. 3G nõrk pulss ärikliendile

    Index Scriptorium Estoniae

    2005-01-01

    Mobi turundusjuht Rain Rannu, Elisa tegevjuht Sami Seppänen, EMT arendus- ja tehnoloogiadirektor Tõnu Grünberg ning andmeside ja sisuteenuste juht Ando Meentalo vaagivad nn kolmanda mobiilipõlvkonna 3G plusse ja miinuseid ning võimalusi Eesti turul läbi lüüa. Lisa: Mobiilivõrgud

  11. Muusika / DJ Pickney Tiger

    Index Scriptorium Estoniae

    DJ Pickney Tiger, pseud., 1970-

    2008-01-01

    Kontsertidest: ansamblid Haydamaky ja Svjata Vatra 14. nov. Tallinnas Amigos ja 15. nov.Viljandis Pärimusmuusika Aidas, 11. nov. Anzori Barkalaja ja Silver Sepp Viljandis Pärimusmuusika Aidas, üritustest Roll & Bass, Rock ja Roll 29. nov. Tartus, Jõulujazz 29. nov. -16. dets., Tricky 20. nov. Tallinnas Rock Cafés

  12. Ahp2 (Hop2) function in Arabidopsis thaliana (Ler) is required for stabilization of close alignment and synaptonemal complex formation except for the two short arms that contain nucleolus organizer regions.

    Science.gov (United States)

    Stronghill, P; Pathan, N; Ha, H; Supijono, E; Hasenkampf, C

    2010-08-01

    A cytological comparative analysis of male meiocytes was performed for Arabidopsis wild type and the ahp2 (hop2) mutant with emphasis on ahp2's largely uncharacterized prophase I. Leptotene progression appeared normal in ahp2 meiocytes; chromosomes exhibited regular axis formation and assumed a typical polarized nuclear organization. In contrast, 4',6'-diamidino-2-phenylindole-stained ahp2 pachytene chromosome spreads demonstrated a severe reduction in stabilized pairing. However, transmission electron microscopy (TEM) analysis of sections from meiocytes revealed that ahp2 chromosome axes underwent significant amounts of close alignment (44% of total axis). This apparent paradox strongly suggests that the Ahp2 protein is involved in the stabilization of homologous chromosome close alignment. Fluorescent in situ hybridization in combination with Zyp1 immunostaining revealed that ahp2 mutants undergo homologous synapsis of the nucleolus-organizer-region-bearing short arms of chromosomes 2 and 4, despite the otherwise "nucleus-wide" lack of stabilized pairing. The duration of ahp2 zygotene was significantly prolonged and is most likely due to difficulties in chromosome alignment stabilization and subsequent synaptonemal complex formation. Ahp2 and Mnd1 proteins have previously been shown, "in vitro," to form a heterodimer. Here we show, "in situ," that the Ahp2 and Mnd1 proteins are synchronous in their appearance and disappearance from meiotic chromosomes. Both the Ahp2 and Mnd1 proteins localize along the chromosomal axis. However, localization of the Ahp2 protein was entirely foci-based whereas Mnd1 protein exhibited an immunostaining pattern with some foci along the axis and a diffuse staining for the rest of the chromosome.

  13. In silico analysis of β-mannanases and β-mannosidase from Aspergillus flavus and Trichoderma virens UKM1

    Science.gov (United States)

    Yee, Chai Sin; Murad, Abdul Munir Abdul; Bakar, Farah Diba Abu

    2013-11-01

    A gene encoding an endo-β-1,4-mannanase from Trichoderma virens UKM1 (manTV) and Aspergillus flavus UKM1 (manAF) was analysed with bioinformatic tools. In addition, A. flavus NRRL 3357 genome database was screened for a β-mannosidase gene and analysed (mndA-AF). These three genes were analysed to understand their gene properties. manTV and manAF both consists of 1,332-bp and 1,386-bp nucleotides encoding 443 and 461 amino acid residues, respectively. Both the endo-β-1,4-mannanases belong to the glycosyl hydrolase family 5 and contain a carbohydrate-binding module family 1 (CBM1). On the other hand, mndA-AF which is a 2,745-bp gene encodes a protein sequence of 914 amino acid residues. This β-mannosidase belongs to the glycosyl hydrolase family 2. Predicted molecular weight of manTV, manAF and mndA-AF are 47.74 kDa, 49.71 kDa and 103 kDa, respectively. All three predicted protein sequences possessed signal peptide sequence and are highly conserved among other fungal β-mannanases and β-mannosidases.

  14. Diaphragm pacing and noninvasive respiratory management of amyotrophic lateral sclerosis/motor neuron disease.

    Science.gov (United States)

    Mahajan, Kedar R; Bach, John Robert; Saporito, Lou; Perez, Nick

    2012-12-01

    Although it is known that continuous noninvasive ventilation (CNIV) can prolong life in amyotrophic lateral sclerosis/motor neuron disease (ALS/MND), in this study we explore similar claims for diaphragm pacing (DP). NIV and DP users' vital capacities (VCs) over time and duration of NIV and CNIV dependence were analyzed for 354 non-DP and 8 DP ALS/MND patients. Patients had a higher rate of monthly VC decline before NIV use (5.1 ± 7.6%) than during NIV use (2.5 ± 3.6%) (P NIV for 19.9 ± 27.6 months until tracheostomy/death, whereas 113 others used it for 10.9 ± 10.5 months until CNIV dependence for another 12.8 ± 16.2 months. After placement, 7 DP users were CNIV dependent in 8.0 ± 7.0 months, whereas 6 underwent tracheostomy/died in 18.2 ± 13.7 months. CNIV prolonged the survival of 113 of the 354 non-DP and 6 DP ALS/MND patients by 12.8 and 10.2 months, respectively. DP provided no benefit on VC or mechanical ventilation-free survival. Copyright © 2012 Wiley Periodicals, Inc.

  15. Experience of long-term use of non-invasive ventilation in motor neuron disease: an interpretative phenomenological analysis.

    Science.gov (United States)

    Ando, Hikari; Chakrabarti, Biswajit; Angus, Robert M; Cousins, Rosanna; Thornton, Everard W; Young, Carolyn A

    2014-03-01

    Although non-invasive ventilation (NIV) can promote quality of life in motor neuron disease (MND), previous studies have disregarded the impact of progression of illness. This study explored how patients' perceptions of NIV treatment evolve over time and how this was reflected in their adherence to NIV. Five patients with MND (male=4, mean age=59 years), from a bigger cohort who were prospectively followed, had multiple post-NIV semistructured interviews, covering more than 12 months, along with ventilator interaction data. The transcribed phenomenological data were analysed using qualitative methodology. Three themes emerged: experience of NIV, influence on attitudes and perceived impact of NIV on prognosis. The ventilator interaction data identified regular use of NIV by four participants who each gave positive account of their experience of NIV treatment, and irregular use by one participant who at interview revealed a negative attitude to NIV treatment and in whom MND induced feelings of hopelessness. This exploratory study suggests that a positive coping style, adaptation and hope are key factors for psychological well-being and better adherence to NIV. More studies are needed to determine these relationships.

  16. Vanemuise "Suur kuri hunt" valiti parimaks lastelavastuseks / Brigitta Davidjants

    Index Scriptorium Estoniae

    Davidjants, Brigitta, 1983-

    2006-01-01

    27. mail lõppenud laste- ja noorteteatrite festivalist "Draamake 2006". Lastelavastuse auhinna sai Vanemuise "Suur kuri hunt" (lavastaja Taago Tubin), noorsooteatri auhind määrati Vene Teatri lavastusele "Veerevad kivid ei sammaldu" (lavastaja Nikita Grinshpun), näitlejaauhinnaga pärjati Marika Vaarikut osatäitmise eest VAT Teatri lavastuses "Klammi sõda", publikupuudutuse auhinna sai ZUGA ühendatud tantsijate "ZUGA lastekas" ja sõnajõuauhind läks NO99 teatri lavastusele "Kaks päikest"( lavastaja Andres Noormets)

  17. 4 maja lugu / Tiina Kolk

    Index Scriptorium Estoniae

    Kolk, Tiina

    2006-01-01

    Keskaegses kaupmeheelamus Lai tänav 23 paikneb Tallinna Linnateater (taastamistööde juht Teddy Böckler). Endisesse raadiotehasesse Punane RET Tallinnas on ehitatud Sampo panga peakontor (arhitektid Jüri Okas ja Marika Lõoke). Tartus Munga tänaval Eesti Panga Tartu majas (arhitektid Arnold Matteus ja Karl Burman, uue ruumiprogrammi kavandajad Uko Künnap ja Aivar Roosaar) asub Eesti Vabariigi Haridusministeerium. Pärnus endises Herman Leopold Ammende eramus (Peterburi arhitektuuribüroo Mieritz & Gerassimov, renoveeris Aivar Roosaar) asub hotell

  18. Study on antioxidant experiment on forged steel tube sheet and tube hole for steam generator

    International Nuclear Information System (INIS)

    Zong Hai; Wang Detai; Ding Yang

    2012-01-01

    Antioxidant experiment on forged steel tube sheet and tube hole for steam generator was studied and the influence of different simulated heat treatments on the antioxidant performance of tube sheet and tube hole was made. The influence of different antioxidant methods on the size of tube hole was drawn. Furthermore, the change of size and weight of 18MnD5 forged steel tube sheet on the condition of different simulated heat treatments was also studied. The analytical results have proved reference information for the use of 18MnD5 material and for key processes of processing tube hole and wearing and expanding U-style tube. (authors)

  19. Sami Seppänen : kõnehinna langus hakkab otsa saama / Sami Seppänen ; interv. Henrik Ilves

    Index Scriptorium Estoniae

    Seppänen, Sami

    2007-01-01

    Elisa juhatuse esimehe hinnangul halvab hindade tõstmine ja siis ümberotsustamine mulje kogu mobiilside tegevusalast. Elisa ei kaalunud võimalust EMT sammuga - võtta kasutusele minutipõhine kõnearvestus - kaasa minna, kuid pole välistatud, et tulevikus Elisa seda teeb. Lisa: Konkurendid on sama meelt

  20. USAs avati suurim Balti kunsti näitus / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2002-01-01

    New Jerseys Rutgersi ülikooli kunstimuuseumis on väljas 190 Eesti, Läti ja Leedu kunstniku tööd Norton ja Nancy Dodge'i mitte-konformistliku nõukogude kunsti kollektsioonist, mille omanikud ülikoolile kinkisid. Näitusekataloogi artiklid on kirjutanud Juta Kivimäe, Eha Komissarov, Sirje Helme ja kanadalane Eha Sepp

  1. Ostetud lõputööga saaks ülikoolidiplomi kätte küll / Kristi Leppik

    Index Scriptorium Estoniae

    Leppik, Kristi

    2008-01-01

    Plagiaadist, autoriõigusest ja lõputööde ostmisest ajakirjandusliku eksperimendina korraldatud õigusteaduse bakalaureuse lõputöö hankimise näitel Kommenteerivad Tallinna Tehnikaülikooli ehitusteaduskonna dekaan Roode Liias, Akadeemia Nord õigusteaduste dekaan Aare Kruuser, Tartu Ülikooli majandusteaduskonna arenduspordekaan Jüri Sepp, Tallinna Ülikooli riigireaduste instituudi direktor Leif Kalev

  2. Selenoprotein P in colitis-associated carcinoma

    Science.gov (United States)

    Short, Sarah P.; Whitten-Barrett, Caitlyn; Williams, Christopher S.

    2016-01-01

    ABSTRACT Patients with inflammatory bowel disease are often deficient in micronutrients such as selenium and have an increased risk of colon cancer. We tested whether the selenium transport protein, selenoprotein P, could modify colitis-associated cancer. Our results indicate that global SEPP1 haploinsufficiency augments tumorigenesis and mediates oxidative damage in the intestine. PMID:27314080

  3. Männik ohverdas Aaviksoo

    Index Scriptorium Estoniae

    2003-01-01

    Eesti Telekomi nõukogu otsusest vabastada ametist EMT juhatuse esimees Peep Aaviksoo, uuest kandidaadist Valdo Kalmust ning EMT ja Elioni võimalikust ühinemisest. Diagramm: EMT turuosa libiseb Tele2-le. Vt. samas: EMT lahkuva juhi Peep Aaviksoo avalik kiri. Kommenteerivad Sami Seppänen, Üllar Jaaksoo, Monika Salu, Jaak Aaviksoo, Toomas Tamsar

  4. Minutipõhise hinnaarvestuse katse - kas julgus või rumalus? / Imbi Ernits-Kaljuste

    Index Scriptorium Estoniae

    Ernits-Kaljuste, Imbi, 1963-

    2008-01-01

    EMT teatas 2007. aasta sügisel üleminekust mobiilikõnede minutipõhisele hinnaarvestusele, mis tõi kaasa avalikkuse pahameele, seejärel teatas EMT plaanist loobumisest. Autor tõstatab küsimuse, kumma teatega tegi EMT vea. Kommenteerivad Kaja Pino, Janek Mäggi, Kristjan Seema, Daniel Vaarik, Sami Seppänen, Ivo Rull

  5. Mobiilside uustulnukad võtavad alles hoogu / Villy Paimets

    Index Scriptorium Estoniae

    Paimets, Villy, 1972-

    2004-01-01

    Uued mobiilsideoperaatorid Vertelson Mobiil, CityGSM ja Top Connect valmistuvad turuletulekut ette. Vt. samas: Villy Paimets. Mobiilsideturul tüli majas. OÜ Top Connect konflikti kavandatavate teenuste osutamise pärast läbi Radiolinja võrgu kommenteerivad Radiolinja Eesti juhatuse esimehelt Sami Seppänenilt ja OÜ Top Connect juhatuse liikmelt Vladislav Sobolevilt

  6. Vilsandi merepäästejaama paadikuur ja slipp = Vilsandi sea rescue station boathouse and slip

    Index Scriptorium Estoniae

    2015-01-01

    Vilsandi merepäästejaama paadikuur ja slipp Kihelkonna vallas Saare maakonnas. Arhitektuuri sihtkapitali restaureerimispreemia 2012 lagunemisele määratud väikeobjekti uuele elule toomise eest. Arhitektid Emil Urbel, Ainar Luik (AB Emil Urbel). Värava embleemi taastamine Tiit Pääsuke. Muinsuskaitse eritingimused Leele Välja, muinsuskaitseline järelevalve Tõnu Sepp

  7. Teatri aastaauhindade nominendid

    Index Scriptorium Estoniae

    2006-01-01

    Lavastajaauhind : Merle Karusoo, Elmo Nüganen, Tiit Ojasoo, Ene-Liis Semper, Kristian Smeds, Hendrik Toompere jun, Ingomar Vihmar ; kunstnikuauhind : Iir Hermeliin, Liina Keevallik, Ene-Liis Semper, Aime Unt, Ervin Õunapuu ; naisnäitleja auhind : Ülle Kaljuste, Kaie Mihkelson, Harriet Toompere, Marika Vaarik, Liina Vahtrik ; meesnäitleja auhind : Ain Lutsepp, Rein Oja, Rain Simmul, Tarvo Sõmer, Tambet Tuisk, Aarne Üksküla ; Balleti- ja tantsuteater : Marina Tshirkova, Seki Hirotaka, Mari Savitski, Oksana Titova, Taavet Jansen, Sasha Pepeljajev, Katrin Essenson ja Tantsuteater Fine 5

  8. Teatri aastaauhindadele kandideerijad selgunud

    Index Scriptorium Estoniae

    2006-01-01

    Lavastajaauhind : Merle Karusoo, Elmo Nüganen, Tiit Ojasoo, Ene-Liis Semper, Kristian Smeds, Hendrik Toompere jun, Ingomar Vihmar ; kunstnikuauhind : Iir Hermeliin, Liina Keevallik, Ene-Liis Semper, Aime Unt, Ervin Õunapuu ; naisnäitleja auhind : Ülle Kaljuste, Kaie Mihkelson, Harriet Toompere, Marika Vaarik, Liina Vahtrik ; meesnäitleja auhind : Ain Lutsepp, Rein Oja, Rain Simmul, Tarvo Sõmer, Tambet Tuisk, Aarne Üksküla ; Balleti- ja tantsuteater : Marina Tshirkova, Seki Hirotaka, Mari Savitski, Oksana Titova, Taavet Jansen, Sasha Pepeljajev, Katrin Essenson ja Tantsuteater Fine 5

  9. Supporting wellbeing in motor neurone disease for patients, carers, social networks, and health professionals: A scoping review and synthesis.

    Science.gov (United States)

    Harris, Melanie; Thomas, Geoff; Thomas, Mary; Cafarella, Paul; Stocks, Allegra; Greig, Julia; McEvoy, R Doug

    2018-04-01

    ABSTRACTObjective:Disease management in motor neurone disease (MND) is focused on preserving quality of life. However, the emphasis has so far been on physical symptoms and functioning and not psychosocial wellbeing. MND affects the wellbeing of carers, of family and social network members, and of healthcare providers, as well as of the patients. We therefore aimed to assess and synthesize the knowledge about maximizing MND-related psychosocial wellbeing across all these groups. We used a systematic search and selection process to assess the scope of the literature along with a narrative synthesis of recent high-quality reviews. The original studies were mainly observational studies of patients and, to a lesser extent, of carers. There were few interventional studies, mainly of patients. There were very few studies of any type on wellbeing in their wider social network or in healthcare professionals. All the review literature looked at MND patient or carer wellbeing, with some covering both. No reviews were found of wellbeing in other family members, patients' social networks, or their healthcare professionals. The reviews demonstrated wellbeing problems for patients linked to psychosocial issues. Carer wellbeing is also compromised. Psychotherapies, social supports, improved decision supports, and changes to healthcare delivery are among the suggested strategies for improved patient and carer wellbeing, but no proven interventions were identified for either. Early access to palliative care, also not well-tested but recommended, is poorly implemented. Work on interventions to deal with well-established wellbeing problems for patients and carers is now a research priority. Explicit use of current methods for patient and public involvement and for design and testing of interventions provide a toolkit for this research. Observational research is needed in other groups. There is a potential in considering needs across patients' social networks rather than looking

  10. Identifying who will benefit from non-invasive ventilation in amyotrophic lateral sclerosis/motor neurone disease in a clinical cohort.

    Science.gov (United States)

    Berlowitz, David J; Howard, Mark E; Fiore, Julio F; Vander Hoorn, Stephen; O'Donoghue, Fergal J; Westlake, Justine; Smith, Anna; Beer, Fiona; Mathers, Susan; Talman, Paul

    2016-03-01

    Respiratory failure is associated with significant morbidity and is the predominant cause of death in motor neurone disease/amyotrophic lateral sclerosis (MND/ALS). This study aimed to determine the effect of non-invasive ventilatory (NIV) support on survival and pulmonary function decline across MND/ALS phenotypes. Cohort recruited via a specialist, multidisciplinary clinic. Patients were categorised into four clinical phenotypes (ALS, flail arm, flail leg and primary lateral sclerosis) according to site of presenting symptom and the pattern of upper versus lower motor neurone involvement. NIV was initiated according to current consensus practice guidelines. Between 1991 and 2011, 1198 patients diagnosed with ALS/MND were registered. 929 patients (77.5%) fulfilled the selection criteria and their data were analysed. Median tracheostomy free survival from symptom onset was 28 months in NIV-treated patients compared to 15 months in untreated (Univariate Cox regression HR=0.61 (0.51 to 0.73), pNIV persisted when the model was adjusted for age, gender, riluzole and percutaneous endoscopic gastrostomy use (HR=0.72 (0.60 to 0.88, p=0.001). In contrast with the only randomised controlled trial, NIV statistically significantly increased survival by 19 months in those with ALS-bulbar onset (Univariate HR=0.50 (0.36 to 0.70), multivariate HR=0.59 (0.41 to 0.83)). These data confirm that NIV improves survival in MND/ALS. The overall magnitude of benefit is 13 months and was largest in those with ALS-bulbar disease. Future research should explore the optimal timing of NIV initiation within phenotypes in order to optimise respiratory function, quality of life and survival. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  11. EMG analysis in 78 cases with motor neuron disease

    Institute of Scientific and Technical Information of China (English)

    Zhang Qiubin

    2000-01-01

    This paper analysed the FMGs of 78 cases with the motor neuron disease(MND). The EMG of all patients showed following characteristics that the average duration of wave prolonged, the average voltage increased and it was found that fibrillation and fasciculatton potentials appeared spontaneously. The fibrillation potential of ENG waa related to course of disease. In the patients whose course of disease was short, the fibri llation potential increased obviously, while in the cases of chronic MND, It usually decreased. The motor nerve conduction velocity of most pa tients (41%) reduced, however, the sensory nerve conduction velocity was normal but two. We reviewed some references about EMG of the motor neuron disease and discussed their characteristics and mechanism

  12. EBSCO infopäev Tallinnas / Marika Meltsas

    Index Scriptorium Estoniae

    Meltsas, Marika

    2008-01-01

    16. aprillil 2008 toimus Tallinnas EBSCO (Elton B. Stephens Company) infopäev, kus maailma suurim elektrooniliste ja trükiajakirjade vahendaja tutvustas oma tooteid ja teenuseid Eesti raamatukogudele. Kommentaar korraldajalt Tiina Nurmilt

  13. Eesti tervishoid - Euroopa punane latern / Marika Tuus

    Index Scriptorium Estoniae

    Tuus, Marika, 1951-

    2005-01-01

    Ilmunud ka: Nädaline 3. märts lk. 4, Elva Postipoiss 5. märts lk. 4, Valgamaalane 12. märts lk. 2, Hiiu Leht 8. apr. lk. 2. Autori sõnul on Eesti tervishoiu rahastamise poolest Euroopas viimasel kohal, kulutades selleks alla 5% SKP-st

  14. Eesti seadused kolivad igaveseks internetti / Marika Seppius

    Index Scriptorium Estoniae

    Seppius, Marika, 1959-

    2005-01-01

    1. jaanuarist 2007 on elektrooniline Riigi Teataja ainus ametlik väljaanne. Sama ka: Põhjarannik 26. juuli 2005, lk. 2 ; Virumaa Teataja 28. juuli 2005, lk. 7 ; Võrumaa Teataja 30. juuli 2005, lk. 2 ; Sakala 4. aug. 2005, lk. 2 ; Pärnu Postimees 4. aug. 2005, lk. 15 ; Vooremaa 4. aug. 2005, lk. 2 ; Valgamaalane 11. aug. 2005, lk. 2 ; Koit 13. aug. 2005, lk. 6

  15. Baltic beer market : close neighbours, different situations

    Index Scriptorium Estoniae

    2004-01-01

    Baltimaade juhtivate õlletootjate marketingijuhid Martins Dzenis (Cesu Alus), Inita Drezina (Aldaris), Eriks Kalita (Livu Alus), Raimonds Kalnins (Kimmel), Dalius Rutkauskas (AB Ragutis), Dainius Smailys (Svyturis-Utenos Alus), Katrin Vernik (A. Le Coq Eesti), Karin Sepp (Saku Õlletehas) ja Härmo Põlluvee (Frederik Viru Õlu) olukorrast Baltimaade õlleturul, suurematest tarbijamängudest ja reklaamikampaaniatest. Tabelid

  16. Potchefstroom Electronic Law Journal/Potchefstroomse Elektroniese ...

    African Journals Online (AJOL)

    What Intellectual Property lawyers can Learn from Barbra Streisand, Sepp Blatter, and the "Coca-Cola Cry-Baby": Dealing with "Trademark Bullying" in South Africa · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. AM Louw, 1-42. http://dx.doi.org/10.4314/pelj.v16i5.1 ...

  17. Lääne-Virumaa ettevõtete TOP aastal 2004

    Index Scriptorium Estoniae

    2005-01-01

    Tabelid: Lääne-Virumaa ettevõtete TOP 50; Käibe TOP 35; Kasumi TOP 35; Lääne-Virumaa ettevõtete üld- ja finantsandmed; Käibe kasvu TOP 20; Kasumi kasvu TOP 20; Rentaabluse TOP 20; Omakapitali tootlikkuse TOP 20. Vt. samas: Viktor Sepp, Merike Lees. Lääne-Virumaal üllatavad uued tegijad

  18. Konkurss eesti-oma-kuub

    Index Scriptorium Estoniae

    2008-01-01

    ERKL konkursist "Eesti oma kuub", kus I preemia pälvisid M. Kalle valmistatud jakk ja J. Saare mantel. II-IV kohta jagasid K. Sepp, I. Antson ja R. Vilusaar. Eripreemiad pälvisid: K. Nurk (kõige novaatorlikum töö), K. Loite (kõige ootamatum lahendus), U. Kangro ja M. Sims (parim lastetöö)

  19. Differential regional cerebral glucose metabolism in clinical syndromes of frontotemporal lobar degeneration: a study with FDG PET

    International Nuclear Information System (INIS)

    Park, J. M.; Cho, S. S.; Na, D. L.; Lee, K. H.; Choi, Y.; Choe, Y. S.; Kim, B. T.; Kim, S. E.

    2001-01-01

    Frontotemporal lobar degeneration( FTLD) is the third most common dementia, following Alzheimer's disease and Lewy body disease. Four prototypic neurobehavioral syndromes can be produced by FTLD: frontotemporal dementia (FTD), frontotemporal dementia with motor neuron disease (MND), semantic dementia (SD), and progressive aphasia (PA). We investigated patterns of metabolic impairment in patient with FTLD presented with four different clinical syndromes. We analysed glucose metabolic patterns on FDG PET images obtained from 34 patients with a clinical diagnosis of FTLD (19 FTD, 6 MND, 6 SD, and 3 PA, according to a consensus criteria for clinical syndromes associated with FTLD) and 7 age-matched healthy controls using SPM99. Patients with FTD had metabolic deficit in the left frontal cortex and bilateral anterior temporal cortex. Hypometabolism in the bilateral premotor are was shown in patients with MND. Patients with SD had metabolic deficit in the left posterior temporal cortex including Wernicke's area, while hypometabolism in the bilateral inferior frontal gyrus including Broca's area and left angular gyrus was seen in patients with PA. These metabolic patterns were well correlated with clinical features of FTLD syndromes. These data provide a biochemical basis of clinical classification of FTLD. FDG PET may help evaluate and classify patients with FTLD

  20. Regional cerebral glucose metabolism in frontotemporal lobar degeneration

    International Nuclear Information System (INIS)

    Park, J.M.; Cho, S.S.; Lee, K.-H.; Choi, Y.; Choe, Y.S.; Kim, B.-T.; Kim, S.E.; Kwon, J.C.; Na, D.L.

    2002-01-01

    Purpose: Frontotemporal lobar degeneration (FTLD) is the third most common cause of dementia, following Alzheimer's disease and Lewy body disease. Four prototypic neuro behavioral syndromes can be produced by FTLD: frontotemporal dementia (FTD), frontotemporal dementia with motor neuron disease (MND), semantic dementia (SD), and progressive aphasia (PA). We investigated patterns of metabolic impairment in patients with FTLD presented with four different clinical syndromes. Methods: We analyzed glucose metabolic patterns on FDG PET images obtained from 34 patients with a clinical diagnosis of FTLD (19 FTD, 6 MND, 6 SD, and 3 PA, according to a consensus criteria for clinical syndromes associated with FTLD) and 7 age-matched healthy controls using SPM99. Results: Patients with FTD had metabolic deficit in the left frontal cortex and bilateral anterior temporal cortex. Hypometabolism in the bilateral pre-motor area was shown in patients with MND. Patients with SD had metabolic deficit in the left posterior temporal cortex including Wernicke's area, while hypometabolism in the bilateral inferior frontal gyrus including Broca's area and left angular gyrus was seen in patients with PA. These metabolic patterns were well correlated with clinical and neuropsychological features of FTLD syndromes. Conclusion: These data provide a biochemical basis of clinical classification of FTLD. FDG PET may help evaluate and classify patients with FTLD

  1. Differential regional cerebral glucose metabolism in clinical syndromes of frontotemporal lobar degeneration: a study with FDG PET

    Energy Technology Data Exchange (ETDEWEB)

    Park, J. M.; Cho, S. S.; Na, D. L.; Lee, K. H.; Choi, Y.; Choe, Y. S.; Kim, B. T.; Kim, S. E. [College of Medicine, Sungkyunkwan Univ., Seoul (Korea, Republic of)

    2001-07-01

    Frontotemporal lobar degeneration( FTLD) is the third most common dementia, following Alzheimer's disease and Lewy body disease. Four prototypic neurobehavioral syndromes can be produced by FTLD: frontotemporal dementia (FTD), frontotemporal dementia with motor neuron disease (MND), semantic dementia (SD), and progressive aphasia (PA). We investigated patterns of metabolic impairment in patient with FTLD presented with four different clinical syndromes. We analysed glucose metabolic patterns on FDG PET images obtained from 34 patients with a clinical diagnosis of FTLD (19 FTD, 6 MND, 6 SD, and 3 PA, according to a consensus criteria for clinical syndromes associated with FTLD) and 7 age-matched healthy controls using SPM99. Patients with FTD had metabolic deficit in the left frontal cortex and bilateral anterior temporal cortex. Hypometabolism in the bilateral premotor are was shown in patients with MND. Patients with SD had metabolic deficit in the left posterior temporal cortex including Wernicke's area, while hypometabolism in the bilateral inferior frontal gyrus including Broca's area and left angular gyrus was seen in patients with PA. These metabolic patterns were well correlated with clinical features of FTLD syndromes. These data provide a biochemical basis of clinical classification of FTLD. FDG PET may help evaluate and classify patients with FTLD.

  2. Prof. Tiina Kirsi raamatuesitlus Toronto Ülikoolis : uus ingliskeelne raamat eesti naiste elulugudest / Eda Sepp ; fotod: Eda Sepp

    Index Scriptorium Estoniae

    Sepp, Eda

    2004-01-01

    20. mail 2004 toimus Toronto Ülikooli Eesti Õppetooli juures Tiina Ann Kirsi toimetatud ja Tartu Ülikooli väljaandena 2004. a. ilmunud raamatu "She who remembers survives : interpreting Estonian women's post-soviet life stories" esitlus, kus toimetaja andis põhjaliku ülevaate teose olemusest ning eesmärkidest

  3. 1970. aastatel alustas arhitektidest sõprade ja kolleegide rühm... / Mari Laanemets

    Index Scriptorium Estoniae

    Laanemets, Mari, 1975-

    2008-01-01

    27.VI avatakse Eesti Arhitektuurimuuseumis Rotermanni soolalaos 1970. ja 1980. alguse eksperimentaalset arhitektuuripraktikat käsitlev näitus "Keskkond, objektid, kontseptsioonid. Tallinna kooli arhitektid 1972-1985". Näha saab Ülevi Eljandi, Ignar Fjuki, Veljo Kaasiku, Tiit Kaljundi, Vilen Künnapu, Leonhard Lapini, Avo-Himm Looveere, Kristin-Mari Looveere, Marika Lõokese, Jüri Okase, Jaan Olliku, Ain Padriku, Toomas Reinu, Andres Ringo, Sirje Runge, Harry Sheini, Tõnis Vindi ja Matti Õunapuu töid. Näituse kuraatorid Andres Kurg ja Mari Laanemets. Samas: "Uue arhitektuuri näituse programm" (1972)

  4. Hea teater lastele ja noortele / Katrin Ruus

    Index Scriptorium Estoniae

    Ruus, Katrin

    2006-01-01

    22.-27. maini Tallinnas, Tartus, Pärnus, Narvas toimunud laste- ja noortetatrite festivalist "Draamake 2006". Nimetatud auhinnasaajad : lastelavastuse auhinna sai Vanemuise "Suur kuri hunt" (lavastaja Taago Tubin), noorsooteatri auhind määrati Vene Teatri lavastusele "Veerevad kivid ei sammaldu" (lavastaja Nikita Grinshpun), näitlejaauhinnaga pärjati Marika Vaarikut osatäitmise eest VAT Teatri lavastuses "Klammi sõda", publikupuudutuse auhinna sai ZUGA ühendatud tantsijate "ZUGA lastekas" ja sõnajõuauhind läks NO99 teatri lavastusele "Kaks päikest" (lavastaja Andres Noormets)

  5. Suomi-englanti-suomi taskusanakirja gastroenterologisen osaston sairaanhoitajille

    OpenAIRE

    Seppä, Maija; Ollilainen, Pauliina

    2013-01-01

    Ollilainen, Pauliina & Seppä, Maija. Suomi-englanti-suomi-taskusanakirja gastroenterologisen osaston sairaanhoitajille, Helsinki, syksy 2013, 57 s., liitteitä 2 Diakonia-ammattikorkeakoulu, Terveysalan koulutusohjelma, terveydenhoitaja/sairaanhoitaja. Opinnäytetyön tarkoituksena oli tuottaa helppokäyttöinen taskusanakirja helpottamaan potilaan ja hoitajan kommunikointia gastroenterologisella osastolla. Sanakirjan avulla hoitajien ja potilaiden välinen kommunikointi paranee, jolloin myös ...

  6. Peep Aaviksoo kukutas EMT-kesksus / Jaan Männik ; interv. Vallo Toomet

    Index Scriptorium Estoniae

    Männik, Jaan, 1945-

    2003-01-01

    EMT nõukogu esimees ja Eesti Telekomi juhatuse esimees Jaan Männik vastab küsimustele, mis on seotud Peep Aaviksoo lahkumisega Eesti Mobiiltelefoni juhi kohalt. Vt. samas: Aaviksoo selgitab lahkumise põhjusi. Peep Aaviksoo kiri. Kommenteerivad Radiolinja Eesti juhatuse esimees Sami Seppänen, Tele2 Eesti juhatuse esimees Üllar Jaaksoo, Ühispanga analüütik Sven Kunsing

  7. Kelle rahanõuandeid kuulate ja kasutate?

    Index Scriptorium Estoniae

    2005-01-01

    Küsimusele vastavad vabakutseline kirjanik Kadri Kõusaar, Riigikogu liige Andres Lipstok, TTÜ üliõpilasesinduse juhatuse esimees Heiki Lemba, IM Arvutite sekretär-raamatupidaja Silja Kalda, Vain SMD konsultant ja koolitaja Urmas Purde, energeetik Peeter Saeraas, Euro Painting and Restoration juht Brian Sepp, Mercuri Urval konsultant Tarmo Müürsepp, Regio osakonnajuhataja Gerri Kodres, OÜ Vastus juht Jelena Rootamm-Valter

  8. Me võime liigutada tooli / Kristina Pai

    Index Scriptorium Estoniae

    Pai, Kristina, 1967-

    2014-01-01

    Põhja- ja Baltimaade raamatukoguhoidjate kohtumisest 2013. aasta septembris Helsingis jagasid muljeid Toila raamatukogu juhataja Lea Rand, Viljandi Linnaraamatukogu lugemissaalide juhataja Veronika Raudsepp-Linnupuu, Lääne Maakonna Keskraamatukogu direktor Ilme Sepp, Võrumaa Keskraamatukogu direktor Inga Kuljus, ERÜ esimees Katre Riisalu, Tallinna Keskraamatukogu direktor Kaie Holm, Tartu Linnaraamatukogu spetsialist Maia Tammjärv, Lääne-Virumaa Keskraamatukogu direktor Kaili Õunapuu-Seidelberg

  9. The President and the Intelligence Community: The Importance of the Relationship

    Science.gov (United States)

    2017-12-01

    Intelligence Successes and Failures in Operations Desert Shield/Storm, (Washington, DC: Government Printing Office, 1993), 2–3, http://www.dtic.mil... Intelligence as Leaders of the U.S. Intelligence Community 1946–2005. Washington, D.C.: Government Printing Office, 2005. Hedley, John Hollister...THE INTELLIGENCE COMMUNITY: THE IMPORTANCE OF THE RELATIONSHIP by Dane M. Holtmeyer December 2017 Thesis Advisor: Kalev I. Sepp

  10. Sundosaõigus ja tagasivõitmine / Katrin Sepp

    Index Scriptorium Estoniae

    Sepp, Katrin

    2017-01-01

    Sundosa mõistest ja sundosa saajatest. Sihtasutusse paigutatud vara arvesse võtmisest sundosa suuruse määramisel, sundosaõigusest tulenevatest nõudetest sihtasutuse vastu ja rahvusvahelistest pärimisasjadest

  11. Sisearhitektuuri uudised / Aino Ingrid Sepp, Aale Kask

    Index Scriptorium Estoniae

    Sepp, Aino Ingrid

    2006-01-01

    Restoran Vertigo Tallinnas, sisekujundus Janno Roos ja Andres Labi; ööklubi Tartus Ülikooli tänava kaubanduskeskuse hoones, sisekujundus Riin Pettai ja Kerli Lepp; ilusalong Medemis Tallinnas, sisekujundus Maris Kerge; tantsustuudio Stiletto endises Marati tootmishoones Tallinnas, sisekujundus Anneli Ahi

  12. Sisearhitektuuri uudised / Aino Ingrid Sepp, Aale Kask

    Index Scriptorium Estoniae

    Sepp, Aino Ingrid

    2007-01-01

    Tallinnas lillesalongi Masha sisekujunduse autorid on Ahti Lyra ja Kristiine Lõuk. Pärnu ööklubi Str sisekujunduse autor on Hannes Praks. Tallinna Viru keskuse avatud baari sisekujunduse autorid on Kärt Villmann ja Andres Rohtla

  13. Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector

    Directory of Open Access Journals (Sweden)

    Swati Singh

    2017-03-01

    Full Text Available Wiskott-Aldrich syndrome (WAS is a life-threatening immunodeficiency caused by mutations within the WAS gene. Viral gene therapy to restore WAS protein (WASp expression in hematopoietic cells of patients with WAS has the potential to improve outcomes relative to the current standard of care, allogeneic bone marrow transplantation. However, the development of viral vectors that are both safe and effective has been problematic. While use of viral transcriptional promoters may increase the risk of insertional mutagenesis, cellular promoters may not achieve WASp expression levels necessary for optimal therapeutic effect. Here we evaluate a self-inactivating (SIN lentiviral vector combining a chromatin insulator upstream of a viral MND (MPSV LTR, NCR deleted, dl587 PBS promoter driving WASp expression. Used as a gene therapeutic in Was−/− mice, this vector resulted in stable WASp+ cells in all hematopoietic lineages and rescue of T and B cell defects with a low number of viral integrations per cell, without evidence of insertional mutagenesis in serial bone marrow transplants. In a gene transfer experiment in non-human primates, the insulated MND promoter (driving GFP expression demonstrated long-term polyclonal engraftment of GFP+ cells. These observations demonstrate that the insulated MND promoter safely and efficiently reconstitutes clinically effective WASp expression and should be considered for future WAS therapy.

  14. Puit linnas - väikevormid / Urmas Oja

    Index Scriptorium Estoniae

    Oja, Urmas, 1981-2012

    2005-01-01

    Tartu Rüütli t. uus kujundus (Rene Valner, Margus Maiste, Ott Kadarik), Vallimäe trepp Rakveres (Siiri Vallner, Heidi Urb, AB Kavakava), Helsingi Tehnikakõrgkooli üliõpilaste Antti Lehto ja Teemu Seppäneni töö Helsindi disaininädala infopaviljoni konkursil, park ja aiamööbel (Nathalie Dubois, Mustapha Sanaoui) kortermajade hoovis Prantsusmaal. 8 värv. ill

  15. Marta maailm / Marta Vaarik

    Index Scriptorium Estoniae

    Vaarik, Marta, 1987-

    2007-01-01

    Riigikogu liige Evelin Sepp käis sir Elton Johni kontserdil 15. sept. Saku Suurhallis. Poplaulja Mike Emelai on kaalus alla võtnud. Riigikogu liige Enn Eesmaa esineb Cliff Richardi looga "Don't Forget To Catch Me" 4. okt. Eesti Vähiliidu korraldataval heategevuskontserdil. "Tantsud tähtedega" saates paarina võistlevad laulja Koit Toome ja tantsija Kerttu Tänav käisid Elton Johni kontserdil

  16. Ag/MnO₂ Nanorod as Electrode Material for High-Performance Electrochemical Supercapacitors.

    Science.gov (United States)

    Guo, Zengcai; Guan, Yuming; Dai, Chengxiang; Mu, Jingbo; Che, Hongwei; Wang, Guangshuo; Zhang, Xiaoliang; Zhang, Zhixiao; Zhang, Xiliang

    2018-07-01

    A one-dimensional hierarchical Ag nanoparticle (AgNP)/MnO2 nanorod (MND) nanocomposite was synthesized by combining a simple solvothermal method and a facile reduction approach in situ. Owing to its high electrical conductivity, the resulting AgNP/MND nanocomposite displayed a high specific capacitance of 314 F g-1 at a current density of 2 A g-1, which was much higher than that of pure MNDs (178 F g-1). Resistances of the electrolyte (Rs) and charge transportation (Rct) of the nanocomposite were much lower than that of pure MNDs. Moreover, the nanocomposite exhibited outstanding long-term cycling ability (9% loss of initial capacity after 1000 cycles). These results indicated that the nanocomposite could serve as a promising and useful electrode material for future energy-storage applications.

  17. Glutathione enzyme and selenoprotein polymorphisms associate with mercury biomarker levels in Michigan dental professionals

    Energy Technology Data Exchange (ETDEWEB)

    Goodrich, Jaclyn M.; Wang, Yi [Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109 (United States); Gillespie, Brenda [Department of Biostatistics, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109 (United States); Werner, Robert [Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109 (United States); Department of Physical Medicine and Rehabilitation, University of Michigan, 325 E. Eisenhower Parkway Suite 100, Ann Arbor, MI 48108 (United States); Franzblau, Alfred [Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109 (United States); Basu, Niladri, E-mail: niladri@umich.edu [Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109 (United States)

    2011-12-15

    Mercury is a potent toxicant of concern to both the general public and occupationally exposed workers (e.g., dentists). Recent studies suggest that several genes mediating the toxicokinetics of mercury are polymorphic in humans and may influence inter-individual variability in mercury accumulation. This work hypothesizes that polymorphisms in key glutathione synthesizing enzyme, glutathione s-transferase, and selenoprotein genes underlie inter-individual differences in mercury body burden as assessed by analytical mercury measurement in urine and hair, biomarkers of elemental mercury and methylmercury, respectively. Urine and hair samples were collected from a population of dental professionals (n = 515), and total mercury content was measured. Average urine (1.06 {+-} 1.24 ug/L) and hair mercury levels (0.49 {+-} 0.63 ug/g) were similar to national U.S. population averages. Taqman assays were used to genotype DNA from buccal swab samples at 15 polymorphic sites in genes implicated in mercury metabolism. Linear regression modeling assessed the ability of polymorphisms to modify the relationship between mercury biomarker levels and exposure sources (e.g., amalgams, fish consumption). Five polymorphisms were significantly associated with urine mercury levels (GSTT1 deletion), hair mercury levels (GSTP1-105, GSTP1-114, GSS 5 Prime ), or both (SEPP1 3 Prime UTR). Overall, this study suggests that polymorphisms in selenoproteins and glutathione-related genes may influence elimination of mercury in the urine and hair or mercury retention following exposures to elemental mercury (via dental amalgams) and methylmercury (via fish consumption). -- Highlights: Black-Right-Pointing-Pointer We explore the influence of 15 polymorphisms on urine and hair Hg levels. Black-Right-Pointing-Pointer Urine and hair Hg levels in dental professionals were similar to the US population. Black-Right-Pointing-Pointer GSTT1 and SEPP1 polymorphisms associated with urine Hg levels. Black

  18. Glutathione enzyme and selenoprotein polymorphisms associate with mercury biomarker levels in Michigan dental professionals

    International Nuclear Information System (INIS)

    Goodrich, Jaclyn M.; Wang, Yi; Gillespie, Brenda; Werner, Robert; Franzblau, Alfred; Basu, Niladri

    2011-01-01

    Mercury is a potent toxicant of concern to both the general public and occupationally exposed workers (e.g., dentists). Recent studies suggest that several genes mediating the toxicokinetics of mercury are polymorphic in humans and may influence inter-individual variability in mercury accumulation. This work hypothesizes that polymorphisms in key glutathione synthesizing enzyme, glutathione s-transferase, and selenoprotein genes underlie inter-individual differences in mercury body burden as assessed by analytical mercury measurement in urine and hair, biomarkers of elemental mercury and methylmercury, respectively. Urine and hair samples were collected from a population of dental professionals (n = 515), and total mercury content was measured. Average urine (1.06 ± 1.24 ug/L) and hair mercury levels (0.49 ± 0.63 ug/g) were similar to national U.S. population averages. Taqman assays were used to genotype DNA from buccal swab samples at 15 polymorphic sites in genes implicated in mercury metabolism. Linear regression modeling assessed the ability of polymorphisms to modify the relationship between mercury biomarker levels and exposure sources (e.g., amalgams, fish consumption). Five polymorphisms were significantly associated with urine mercury levels (GSTT1 deletion), hair mercury levels (GSTP1-105, GSTP1-114, GSS 5′), or both (SEPP1 3′UTR). Overall, this study suggests that polymorphisms in selenoproteins and glutathione-related genes may influence elimination of mercury in the urine and hair or mercury retention following exposures to elemental mercury (via dental amalgams) and methylmercury (via fish consumption). -- Highlights: ► We explore the influence of 15 polymorphisms on urine and hair Hg levels. ► Urine and hair Hg levels in dental professionals were similar to the US population. ► GSTT1 and SEPP1 polymorphisms associated with urine Hg levels. ► Accumulation of Hg in hair following exposure from fish was modified by genotype. ► GSTP1, GSS

  19. Lugemis- ja kuulamissoovitusi lapsemeelsetele : [heliraamatud ja -plaadid lastele] / Esme Kassak

    Index Scriptorium Estoniae

    Kassak, Esme

    2010-01-01

    Arvustus: Jancis, Kaspar. Seiklus Salamandril, ehk, Morten Viksi uskumatud juhtumised lollide laevas. Tallinn : Menu Kirjastus, 2010 ; Kivirähk, Andrus. Kaka ja kevad [Helisalvestis] / loeb Ülle Kaljuste. Tallinn ; Varrak, 2010 ; Kivirähk, Andrus. Kaelkirjak [Helisalvestis] / loeb Harriet Toompere. Tallinn : Varrak, 2010 ; Tungal, Leelo. Hea lapse laulud [Helisalvestis]. Tallinn : Nõmmelill, 2010 ; Pajusaar, Priit. Lapsed, liblikad ja teised mutukad [Helisalvestis]. Tallinn : Varrak, 2010 ; Toman, Eduard. Gena ja teised : [Helisalvestis]. Tallinn : Greenroom Studio, 2010 ; Vilmusenaho, Marika. Tuulejutu viisid [Helisalvestis] / esitavad Meero Muusiku laululapsed. I.k. : Tempo Rubato, 2009 ; Raud, Eno. Sipsik : laste unejutud / loeb Salme Reek. Tallinn : Eesti Rahvusringhääling, 2010

  20. TÜ, TPÜ ja EHI uusi magistreid / Eda Tursk, Hille Roots, Heidi Meier

    Index Scriptorium Estoniae

    Tursk, Eda

    2004-01-01

    Tartu ülikooli eesti ja soome-ugri keeleteaduse osakonnas ning kirjanduse ja rahvaluule osakonnas kaitsesid 2003.a. magistritööd Niina Aasmäe, Piret Voll, Larissa Degel, Reet Hendrikson, Tiina Pai, Petar Kehayov, Anna Baidullina, Katrin Ennus, Kristi Jõesaar, Ell Vahtramäe, Lauri Sommer, Andreas Kalkun, Mirjam Hinrikus, Kristel Nõlvak. Tallinna Pedagoogikaülikoolis kaitsesid 2003.a. magistritööd Sirje Nootre, Merike Mägedi, Tiiu Koovit, Heidi Meier, Jaanika Stackhouse, Lilian Ossi, Annika Vamper, Marika Mikkor, Piret Õunapuu, Helin Puksand, Taimi Rosenberg. Eesti Humanitaarinstituudis kaitses 2003.a. magistritööd Merilin Miljan

  1. Minor neurological dysfunction and cognition in 9-year-olds born at term

    NARCIS (Netherlands)

    Kikkert, Hedwig K; de Jong, Corina; Hadders-Algra, Mijna

    BACKGROUND: In children with developmental disorders, motor problems often co-occur with cognitive difficulties. Associations between specific cognitive deficits underlying learning problems and minor neurological dysfunction (MND) are still unknown. AIMS: To assess associations between specific

  2. My NASA Data

    Data.gov (United States)

    National Aeronautics and Space Administration — MY NASA DATA (MND) is a tool that allows anyone to make use of satellite data that was previously unavailable.Through the use of MND’s Live Access Server (LAS) a...

  3. Maksude äkktõus ja hinnaralli / Marika Tuus

    Index Scriptorium Estoniae

    Tuus, Marika, 1951-

    2007-01-01

    Ilmunud ka: Vali Uudised, 13. juuni 2007, lk. 2; Meie Maa, 20. juuni 2007, lk. 2; Severnoje Poberezhje, 20. juuni 2007, lk. 2; Virumaa Teataja, 21. juuni 2007, lk. 11; Põhjarannik, 21. juuni 2007, lk. 2; Sõnumitooja, 22. juuni 2007, lk. 2; Harjumaa, 26. juuni 2007, lk. 2; Hiiu Leht, 26. juuni 2007, lk. 2; Pärnu Postimees, 27. juuni 2007, lk. 15; Vooremaa : Kallaste Linna Leht, 21. juuli 2007, lk. 2. Autor kritiseerib valitsuskoalitsiooni maksupoliitikat

  4. Valitsus hämab liikluskindlustuse seadusega / Marika Tuus

    Index Scriptorium Estoniae

    Tuus, Marika, 1951-

    2004-01-01

    Ilmunud ka: Vooremaa, 12. veebr. 2004, lk. 2; Elva Postipoiss, 14. veebr. 2004, lk. 4; Meie Maa, 20. veebr. 2004, lk. 2; Vali Uudised, 20. veebr. 2004, lk. 2; Põhjarannik, 21. veebr. 2004, lk. 2; Severnoje Poberezhje, 21. veebr. 2004, lk. 2; Kesknädal, 25. veebr. 2004, lk. 2; Valgamaalane, 16. märts 2004, lk. 6. Kriitiliselt liikluskindlustuse seaduse eelnõust. Liikluskindlustuse seaduse eelnõu arutelust Riigikogus

  5. HIV-infektsioon on seotud nakkuslike haigustega / Marika Kusnets

    Index Scriptorium Estoniae

    Kusnets, Marika

    2004-01-01

    TÜ arstiteaduskonna täienduskeskuse kolmepäevasel kursusel Tallinnas olid kõneks HIV-nakkuse seosed bakteriaalsete ja viiruslike nahahaigustega, parasitaarsete ja seenhaigustega, samuti nakkushaiguste ja seksuaalsel teel edasiantavate haigustega

  6. Aino Ugaste doktoritööst / Marika Veisson

    Index Scriptorium Estoniae

    Veisson, Marika

    2005-01-01

    12. veebruaril 2005. aastal kaitses TPÜ dotsent Aino Ugaste Soomes Jyväskylä Ülikoolis kasvatusteaduste doktori kraadi teemal "The Childs' play world at home and the mothers' role in the play - Laste mängumaailm kodus ja ema roll mängus"

  7. Korruptsioon mittetulundusliikumises / Marika K Arendi Elita von Wolsky

    Index Scriptorium Estoniae

    Arendi Elita von Wolsky, Marika K.

    2001-01-01

    Eesti Mittetulundusühingute ja Sihtasutuste Liidus toimunud erakorralisest koosolekust, kus arutati artikli autori avaldusi, mis olid ajendatud tema avalikus kirjas esitatud küsimustest Mall Hellamile. Vt. samas: Kesknädal, 5. dets. 2001, lk. 9

  8. Lionsi asepresident kiitis Eesti "lõvisid" / Marika Milve

    Index Scriptorium Estoniae

    Milve, Marika, 1968-

    1995-01-01

    Lions klubi Eestis. Vt. ka Meie Maa "Lionsite maailma-assotsiatsiooni teine asepresident Augustino Solivo külastas Saaremaad" 8- juuni, lk. 1, Oma Saar "Augustino Soliva: tavaliselt oskavad inimesed võtta, kuid ei oska anda" 7. juuni, lk. 3

  9. Siddhameditsiin : hästi hoitud saladus / Marika Makarova

    Index Scriptorium Estoniae

    Makarova, Marika

    2013-01-01

    Vestlusest Šveitsis elava siddhatohtri Gitanjali Azariah-Theleniga Indias elavate tamilite filosoofiast kui ka loodusmeditsiinist, mille õpetused on kirja pandud Tamil Nadu osariigi templites asuvates iidsetes tamilikeelsetes ürikutes

  10. Tähelepanu keskmes on viiruslik hepatiit / Marika Kusnets

    Index Scriptorium Estoniae

    Kusnets, Marika

    2008-01-01

    Ülemaailmsel hepatiidipäeval 19. mail korraldasid Eesti Gastroenteroloogide Selts (EGS) ja Roche Eesti OÜ meediakanalite esindajatele ümarlaua, et aidata teadvustada C-hepatiidi ohtu, testimis- ja ravivõimalusi Eestis

  11. TEH võrgustik - viis aastat Eestis / Marika Kusnets

    Index Scriptorium Estoniae

    Kusnets, Marika

    2005-01-01

    Eestis on tervist edendavate haiglate (TEH) võrgustik tegutsenud juba viis aastat, sellega on liitunud 22 haiglat. Tänavust konverentsi peeti teemal "Tervise edendamine ja kvaliteedi tagamine haiglas: standardid ja praktika"

  12. Kaubakategooriate juhtimine annab konkurentide ees eelise / Marika Merilai

    Index Scriptorium Estoniae

    Merilai, Marika

    2008-01-01

    Tootekategooriate või ka kaubakategooriate juhtimine on ettevõtte äristrateegia, mis võimaldab jaekaubandusettevõttel saavutada konkurentidest paremaid tulemusi. Kanada turundusprofessori Brent McKenzie sõnul on kaubakategooriate juhtimine keeruline, kuna pole olemas ühte standardset lahendust, kuidas ettevõttes kategooriate juhtimist teostada. Skeem: Kaubakategooriate juhtimise eesmärgid. Kommenteerib ASi A-Selver sortimendijuht Agi Metsandi

  13. Multimodal structural MRI in the diagnosis of motor neuron diseases.

    Science.gov (United States)

    Ferraro, Pilar M; Agosta, Federica; Riva, Nilo; Copetti, Massimiliano; Spinelli, Edoardo Gioele; Falzone, Yuri; Sorarù, Gianni; Comi, Giancarlo; Chiò, Adriano; Filippi, Massimo

    2017-01-01

    This prospective study developed an MRI-based method for identification of individual motor neuron disease (MND) patients and test its accuracy at the individual patient level in an independent sample compared with mimic disorders. 123 patients with amyotrophic lateral sclerosis (ALS), 44 patients with predominantly upper motor neuron disease (PUMN), 20 patients with ALS-mimic disorders, and 78 healthy controls were studied. The diagnostic accuracy of precentral cortical thickness and diffusion tensor (DT) MRI metrics of corticospinal and motor callosal tracts were assessed in a training cohort and externally proved in a validation cohort using a random forest analysis. In the training set, precentral cortical thickness showed 0.86 and 0.89 accuracy in differentiating ALS and PUMN patients from controls, while DT MRI distinguished the two groups from controls with 0.78 and 0.92 accuracy. In ALS vs controls, the combination of cortical thickness and DT MRI metrics (combined model) improved the classification pattern (0.91 accuracy). In the validation cohort, the best accuracy was reached by DT MRI (0.87 and 0.95 accuracy in ALS and PUMN vs mimic disorders). The combined model distinguished ALS and PUMN patients from mimic syndromes with 0.87 and 0.94 accuracy. A multimodal MRI approach that incorporates motor cortical and white matter alterations yields statistically significant improvement in accuracy over using each modality separately in the individual MND patient classification. DT MRI represents the most powerful tool to distinguish MND from mimic disorders.

  14. Multimodal structural MRI in the diagnosis of motor neuron diseases

    Directory of Open Access Journals (Sweden)

    Pilar M. Ferraro

    2017-01-01

    Full Text Available This prospective study developed an MRI-based method for identification of individual motor neuron disease (MND patients and test its accuracy at the individual patient level in an independent sample compared with mimic disorders. 123 patients with amyotrophic lateral sclerosis (ALS, 44 patients with predominantly upper motor neuron disease (PUMN, 20 patients with ALS-mimic disorders, and 78 healthy controls were studied. The diagnostic accuracy of precentral cortical thickness and diffusion tensor (DT MRI metrics of corticospinal and motor callosal tracts were assessed in a training cohort and externally proved in a validation cohort using a random forest analysis. In the training set, precentral cortical thickness showed 0.86 and 0.89 accuracy in differentiating ALS and PUMN patients from controls, while DT MRI distinguished the two groups from controls with 0.78 and 0.92 accuracy. In ALS vs controls, the combination of cortical thickness and DT MRI metrics (combined model improved the classification pattern (0.91 accuracy. In the validation cohort, the best accuracy was reached by DT MRI (0.87 and 0.95 accuracy in ALS and PUMN vs mimic disorders. The combined model distinguished ALS and PUMN patients from mimic syndromes with 0.87 and 0.94 accuracy. A multimodal MRI approach that incorporates motor cortical and white matter alterations yields statistically significant improvement in accuracy over using each modality separately in the individual MND patient classification. DT MRI represents the most powerful tool to distinguish MND from mimic disorders.

  15. Saadikud annavad aru, kas ja kuidas nende palga kallale minna

    Index Scriptorium Estoniae

    2008-01-01

    Ilmunud ka: Postimees : na russkom jazõke 12. märts lk. 2. Riigikogu liikmete vastused küsimustele palga suuruse ja palgasüsteemi muutmise kohta. Lisa: Seisukohti jaganud riigikogulased. Postimees : na russkom jazõke küsimustele vastavad: Villu Reiljan, Jürgen Ligi, Imre Sooäär, Tatjana Muravjova, Evelyn Sepp, Olga Sõtnik, Vladimir Vellman, Jüri Tamm, Peeter Kreitzberg, Aleksei Lotman, Toomas Tõniste, Mart Nutt

  16. Palmse supelmaja taas kasutusel / Anneliis Aunapuu

    Index Scriptorium Estoniae

    Aunapuu, Anneliis

    1998-01-01

    Lahemaa Rahvuspark rentis poolelioleva supelmaja perekond Ong'ile, kes ehituse lõpetas, hoone sisustas ja avas kohvik-restorani 'Freifrau Isabella'. Sisekujundus autor Leila Pärtelpoeg nimetab sisekujundust palladiaanlikuks. Tänu AEL ja Tartu Kunstikooliga sõlmitud lepingule sai supelmaja kõrgetasemelise maalritöö. Maalingud eesruumis ئ Eve Erman. Sepisvalgustid ئ Ülo Sepp. Pika-laua-saalis oleva von Pahlenite vapi valmistas Andres Sapar. Inkrusteeritud puhvetkapi taastas Urmas Ong.

  17. Amyotrophic lateral sclerosis or not: Keys for the diagnosis.

    Science.gov (United States)

    Lenglet, T; Camdessanché, J-P

    2017-05-01

    Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron disease (MND) which prognosis is poor. Early diagnosis permit to set up immediately adapted treatment and cares. Available diagnostic criteria are based on the detection of both central and peripheral motor neuron injury in bulbar, cervical, thoracic and lumbar regions. Electrodiagnostic (EDX) tests are the key tools to identify peripheral motor neuron involvement. Needle examination records abnormal activities at rest, and looks for neurogenic pattern during muscle contraction. Motor unit potentials morphology is modified primary to recruitment. Motor evoked potentials remain the test of choice to identify impairment of central motor neurons. In the absence of diagnostic biomarker of ALS and among essential investigations of suspected MND, a careful clinical and neurophysiological work-up is essential to rule out the differential diagnosis. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  18. Neurological condition assessed with the Hempel examination and cognition and behaviour at 4 years

    NARCIS (Netherlands)

    Schendelaar, Pamela; Seggers, Jorien; Heineman, Maas Jan; Hadders-Algra, Mijna

    Aim: To investigate associations between neurological condition, assessed with the Hempel examination, in terms of minor neurological dysfunction (MND) and neurological optimality, and cognition and behaviour at 4 years. Study design: Cross-sectional analyses within a prospective, assessor-blinded

  19. Pain in Neurodegenerative Disease : Current Knowledge and Future Perspectives

    NARCIS (Netherlands)

    de Tommaso, Marina; Arendt-Nielsen, Lars; Defrin, Ruth; Kunz, Miriam; Pickering, Gisele; Valeriani, Massimiliano

    2016-01-01

    Neurodegenerative diseases are going to increase as the life expectancy is getting longer. The management of neurodegenerative diseases such as Alzheimer's disease (AD) and other dementias, Parkinson's disease (PD) and PD related disorders, motor neuron diseases (MND), Huntington's disease (HD),

  20. Aerobic exercise and congnitive behavioural therapy in ALS: optimzing quality of life

    NARCIS (Netherlands)

    van der Lans-van Groenestijn, A.C.

    2017-01-01

    Amyotrophic lateral sclerosis (ALS) is a fatal progressive adult-onset neurodegenerative motor neuron disease (MND). In the absence of an effective treatment, ALS care focuses on symptom treatment, optimizing functioning (daily activities and social participation) and maintaining quality of life

  1. Evaluation of European District Heating Systems for Application to Army Installations in the United States

    Science.gov (United States)

    2006-07-01

    of the conurbation, the effectiveness of the investments as well as the plant’s management and the owner’s return requirements ( Energia 2004...37 p. Design Manual of ThermoNet Systems. 32 p. (In Finnish). ECONET Manual. 2005. Fläktwoods. Energia 2004. Energy year 2004. “District Heating...Pulliainen, K. 2005. Helsingin Energia . Oral source. Seppänen, O. 1995. ISBN 951-97233-1-5. Heating of Buildings. Publisher Suomen LVI- yhdistyken

  2. Carnitine prevents the early mitochondrial damage induced by methylglyoxal bis(guanylhydrazone) in L1210 leukaemia cells.

    OpenAIRE

    Nikula, P; Ruohola, H; Alhonen-Hongisto, L; Jänne, J

    1985-01-01

    We previously found that the anti-cancer drug methylglyoxal bis(guanylhydrazone) (mitoguazone) depresses carnitine-dependent oxidation of long-chain fatty acids in cultured mouse leukaemia cells [Nikula, Alhonen-Hongisto, Seppänen & Jänne (1984) Biochem. Biophys. Res. Commun. 120, 9-14]. We have now investigated whether carnitine also influences the development of the well-known mitochondrial damage produced by the drug in L1210 leukaemia cells. Palmitate oxidation was distinctly inhibited in...

  3. Homsed disaini- ja furnituurilahendused

    Index Scriptorium Estoniae

    2007-01-01

    Müügijuht Galina Sepp 2006. a. asutatud mööbliettevõttest AIS Furniture (Advanced Interior Solutions), mille tootmistsehh asub Harjumaal Loo alevikus, salong Tallinnas Pärnu mnt. 66. Toodetakse eritellimusel mööblit kööki, elu- ja vannituppa, garderoobi, büroosse ning abiruumidesse. AIS Furniture disaineritelt saab tellida kogu maja või korteri sisekujunduse koos mööbliga. Köökide tehnilised lahendused on pärit furnituuritootjatelt

  4. Loengud seaduseelnõude koostajaile / Margit Kikas

    Index Scriptorium Estoniae

    Kikas, Margit

    2004-01-01

    Eesti Juristide Liidu poolt koostöös Riigikantselei ja Justiitsministeeriumiga korraldatud loengusarjast: Õigusloome ja normitehnika: areng ja probleemid. Sõnavõtjad loengutel: Raul Narits, Katre Kont-Kontson, Lauri Mälksoo, Raigo Sõlg, Jüri Heinla, Anno Aedmaa, Aare Kasemets, Juhani Lemmik, Ülo Siivelt, Külli Koit, Aare Reenumägi, Mall Gramberg, Toomas Sepp, Julia Laffranque, Kristel Aguraiuja, Aime Vettik, Hille Saluäär, Hiie Tamm, Kristina Nõgols, Eve Randvere

  5. 10.-14. II on Puhta Rõõmu alaliiduna tuntud...

    Index Scriptorium Estoniae

    2004-01-01

    Lõkerdus- ja tegevuskunstikollektiiv Naeruorgesster ehk Laffing ahkestra - dirigent Erki Kannus, lõkerdajad Ivika Kivi, Piret Räni, Merle Kannus, Maris Mändel, Marge Monko, Aino Sepp, Annika Kaljurand, Anya Ronacher - esines 11. II Stockholmis Moderna Museeti taasavamispidustuste raames, 12. II osaleti tegevuskunstiprogrammis "Source Live 2004". Aprillis oodatakse kollektiivi Varssavisse Zacheta galerii näitusele "Poisid ja tüdrukud" (16. II-4. IV), kus esitatakse Piret Räni ja Anu Vahtra videot "Punk.Fem.Collection"

  6. Motor neuron disease: the impact of decreased speech intelligibility ...

    African Journals Online (AJOL)

    Background: The onset of motor neuron disease (MND), a neurodegenerative disease, results in physical and communication disabilities that impinge on an individual's ability to remain functionally independent. Multiple aspects of the marital relationship are affected by the continuously changing roles and responsibilities.

  7. Handwriting, visuomotor integration, and neurological condition at school age

    NARCIS (Netherlands)

    van Hoorn, Jessika F.; Maathuis, Carel G. B.; Peters, Lieke H. J.; Hadders-Algra, Mijna

    2010-01-01

    Aim The study investigated the relationships between handwriting, visuomotor integration, and neurological condition. We paid particular attention to the presence of minor neurological dysfunction (MND). Method Participants were 200 children (131 males, 69 females; age range 8-13y) of whom 118

  8. Test-retest, inter-assessor and intra-assessor reliability of the modified Touwen examination

    NARCIS (Netherlands)

    Peters, Lieke H. J.; Maathuis, Karel G. B.; Kouw, Eva; Hamming, Marjolein; Hadders-Algra, Mijna

    Interest in the Touwen examination (1979) for the assessment of minor neurological dysfunction (MND) is growing. However, information on psychometric properties of this assessment is scarce. Therefore the present study aimed at assessing the test's test-retest, inter- and intra-assessor reliability.

  9. Tallinlased kostitavad Euroopa filmitähti / Andreas Sepp

    Index Scriptorium Estoniae

    Sepp, Andreas

    2010-01-01

    Eesti-poolne korraldaja Ave Ungro projektist "Kino kiikab kööki", mille raames kostitavad Tallinna kodud Euroopa Filmiakadeemia gala külalisi. EFA külalist võõrustavast kunstnik Andres Lõost ja kino "Sõprus" loovjuhist Tiina Savist

  10. Baltic cooperation vs Visegrad cooperation (essay) / Tanel Sepp

    Index Scriptorium Estoniae

    Sepp, Tanel

    2004-01-01

    Baltimaade ning Visegrad grupi riikide (Poola, Ungari, Tšehhi, Slovakkia) arengust NSV Liidu mõjusfääris olevatest piirkondadest iseseisvateks riikideks, koostööst Euroopa Liidu ja NATO kontekstis

  11. Olla originaalne ja tähelepandud / Eve Sepp

    Index Scriptorium Estoniae

    Sepp, Eve

    1989-01-01

    Tuntud daamide originaalehetest - tekstiilikunstnik Anna Gerretzi Ülle Kõutsi valmistatud kõrvarõngad, disainer Helle Gansi Katrin Amose loodud rinnanõel, raamatukogudirektrissi Anne Randeli Tiina Käeseli loodud ehted, arhitekt Marka Lõokese Kadri Mälgu loodud komplekt, kunstiteadlase Krista Kodrese Tiina Käeseli loodud komplekt, grimeerija Krista Pärdi abikaasa Rein Metsa loodud ehted

  12. Antibiootikumide kasutamise olukord Euroopas sai avalikuks / Janne Sepp

    Index Scriptorium Estoniae

    Sepp, Janne

    2013-01-01

    Üle-euroopalisest antibiootikumide kasutamise andmete kogumise projektist ESAC, mille eesmärgiks peale usaldusväärsete ja võrreldavate andmete kogumise on ka tähelepanu juhtimine antibiootikumiresistentsuse probleemile

  13. Diivanil hüppamine lubatud! / Aino Ingrid Sepp

    Index Scriptorium Estoniae

    Sepp, Aino Ingrid

    2008-01-01

    Viietoaline stiilne ja lapsesõbralik korter Tallinna vanalinnas. Sisearhitekt Stina Marttinen, tema kommentaarid. Sisekujundus valmis 2008. aastal. Korterile annavad uue ilme Designers Guildi tekstiilid. Köögimööbli valmistas tellimustööna Eesti firma. 17 värv. vaadet

  14. Ohtlikkuse arvestamine karistuse mõistmisel kohtupraktikas / Heili Sepp

    Index Scriptorium Estoniae

    Sepp, Heili, 1975-

    2008-01-01

    Karistusseadustiku tõlgendamisest ja kohtupraktikast karistuse mõistmisel. Artikkel põhineb ettekandel, mille autor pidas Jaan Sootaki 60. juubeli puhul toimunud teaduskonverentsil Tartus 19. sept. 2008

  15. Eesti arengupotentsiaal ja institutsioonide roll / Jüri Sepp

    Index Scriptorium Estoniae

    Sepp, Jüri

    2005-01-01

    Analüüsist järeldus, et Eesti majanduse reaalne arengutase on vaatamata 15 aastat kestnud siirdele ning ühinemisele EL-iga üks Euroopa madalamaid, kuigi majanduse institutsionaalset keskkonda võib pidada nii konkurentsivõimet kui ka majanduskasvu soodustavaks. Tabelid. Diagramm. Skeemid

  16. Jean Nouveli supermodernism Barcelonas / Raili Seppänen

    Index Scriptorium Estoniae

    Seppänen, Raili

    2005-01-01

    2005. a. suvel valmivast prantsuse arhitekti Jean Nouveli (sünd. 1945) projekteeritud tornmajast Torre Agbar Barcelonas Avinguda Diagonal 209-211. Abiks hispaania arhitekt Fermin Vazquez arhitektibüroost b720 Arquitectura S.L. Jean Nouveli tuntud projekte. Ill.: J. Nouveli portreefoto, tornmaja välisvaade

  17. Estonian agriculture after accession : CAP impact / Mati Sepp

    Index Scriptorium Estoniae

    Sepp, Mati, 1945-

    2003-01-01

    Eesti on olnud üks liberaalsema hinna- ja väliskaubanduse korraldusega riike maailmas. Ühinemine ühtse põllumajanduspoliitikaga tähendab aga eelkõige kõrget interventsiooniastet toodete mahu ja hindade kujundamisel ning konservatiivset toiduainete väliskaubanduse korraldust. Tabelid. Graafikud. Diagrammid

  18. Tori Hobune 2011 & Eesti Hobune 2011 / Krista Sepp

    Index Scriptorium Estoniae

    Sepp, Krista

    2011-01-01

    14. mail korraldas Tori Hobusekasvanduse ratsaspordiklubi XVI Tori hobuse päeva ja esimese ettapi karikasarjas Tori Hobune 2011, kus avastardi takistussõidus tegid ka eesti tõugu hobused, ning 15. mail toimus koolisõidu etapp

  19. Natura pälvis maavalitsuse kriitikatule / Andres Sepp

    Index Scriptorium Estoniae

    Sepp, Andres, 1976-

    2004-01-01

    Maavalitsuse hinnangul tuleks Natura aladest välja jätta Suurde väina kavandatava püsiühenduse trassid ja Viirelaid, Küdema lahe äärde rajatava sadama detailplaneeringus käsitletud vee-ala ning faarvaater

  20. Stipendiumiprogramm, mis suunatud stimuleerima noorte arengut / Viire Sepp

    Index Scriptorium Estoniae

    Sepp, Viire, 1955-

    2014-01-01

    Programmist, mis väärtustab reaalainete olümpiaade, kui võimekate noorte arengu üht olulist stiimulit. Tallinna Tehnikaülikooli üliõpilase Mette Purde, Harvardi ülikooli üliõpilase Erik Tamre, Cambridge'i ülikooli üliõpilase Jaan Tootsi ning Tartu Ülikooli üliõpilaste Janno Veeorg, Lona Liisa Sutt, Madis Ollikainen ja Jaagup Repän arvamused olümpiaadide olulisusest

  1. Clinical profile of motor neuron disease patients with lower urinary tract symptoms and neurogenic bladder.

    Science.gov (United States)

    Vázquez-Costa, Juan Francisco; Arlandis, Salvador; Hervas, David; Martínez-Cuenca, Esther; Cardona, Fernando; Pérez-Tur, Jordi; Broseta, Enrique; Sevilla, Teresa

    2017-07-15

    Lower urinary tract symptoms (LUTS) are frequent in motor neuron disease (MND) patients, but clinical factors related to them are unknown. We describe differences in LUTS among MND phenotypes and their relationship with other clinical characteristics, including prognosis. For this study, we collected clinical data of a previously published cohort of patients diagnosed with classical amyotrophic lateral sclerosis (cALS), progressive muscular atrophy (PMA) or primary lateral sclerosis (PLS) with and without LUTS. Familial history was recorded and the C9ORF72 expansion was analysed in the entire cohort. Patients were followed-up for survival until August 2016. Fifty-five ALS patients (37 cALS, 10 PMA and 8 PLS) were recruited. Twenty-four reported LUTS and neurogenic bladder (NB) could be demonstrated in nine of them. LUTS were not influenced by age, phenotype, disability, cognitive or behavioural impairment, or disease progression, but female sex appeared to be a protective factor (OR=0.39, p=0.06). Neither family history nor the C9ORF72 expansion was linked to LUTS or NB. In the multivariate analysis, patients reporting LUTS early in the disease course tended to show poorer survival. In this study, LUTS appear to be more frequent in male MND patients, but are not related to age, clinical or genetic characteristics. When reported early, LUTS could be a sign of rapid disease spread and poor prognosis. Further prospective longitudinal and neuroimaging studies are warranted to confirm this hypothesis. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Studies on motor neuron disease with cranial magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Mitsui, Yoshiyuki; Takahashi, Mitsuo; Nakamura, Yusaku; Kitaguchi, Masataka; Yagi, Yuji (Kinki Univ., Osaka (Japan). School of Medicine)

    1992-05-01

    The present study was performed to examine the pyramidal tracts of the brain in both 51 normal subjects (21 male and 30 female subjects; mean age of 43.5[+-]16.1 years) and 12 patients with motor neuron disease (6 male and 6 female patients; mean age of 57.4[+-]7.9 years), using the magnetic resonance imaging (MRI). The 12 patients with motor neuron disease (MND) comprised 7 suffering from spinal progressive muscular atrophy (SPMA) and 5 from amyotrophic lateral sclerosis (ALS). The MRI used in this study was of both short spin echo and long spin echo sequence. Of the 52 normal subjects, 24 of them (47%) had the T2 prolonged small areas (high signal intensity areas) at the posterior limb of internal capsule. These findings were not found in the normal subjects over fifty years old. No similar finding was detected in the pyramidal tracts except the posterior limb of internal capsule. On the other hand, 8 patients with MND (67%) proved to have the high signal intensity areas in the pyramidal tracts. Moreover, these high intensity areas were extended from the crus cerebri to corona radiata in 7 patients (58%). In all patients with ALS, these areas were extended in whole areas of the pyramidal tracts, and the similar findings were also found in two patients with SPMA. These findings were demonstrated to be more extensive than those in the normal subjects. The results thus obtained warrant us to conclude that cranial MRI is useful to detect the degeneration of the pyramidal tracts of MND patients. (author).

  3. CSF glial markers correlate with survival in amyotrophic lateral sclerosis.

    Science.gov (United States)

    Süssmuth, S D; Sperfeld, A D; Hinz, A; Brettschneider, J; Endruhn, S; Ludolph, A C; Tumani, H

    2010-03-23

    In neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), CSF biomarkers are increasingly studied to evaluate their relevance for differential diagnosis, disease progression, and understanding of pathophysiologic processes. To identify a biomarker profile of neuronal and glial CSF proteins to discriminate ALS from other motor neuron diseases (MND) and to assess whether baseline levels of CSF measures in ALS are associated with the course of the disease. A total of 122 consecutive subjects with MND were included in this cross-sectional study (ALS, n = 75; lower motor neuron syndrome, n = 39; upper motor neuron diseases, n = 8). Clinical follow-up included 76 patients. We determined baseline levels of protein tau and astroglial S100beta in CSF and microglial sCD14 in CSF and serum in relation to diagnosis, duration of disease, and survival. CSF tau was significantly elevated in ALS and upper motor neuron diseases as compared to lower motor neuron diseases and controls. CSF S100beta levels were significantly lower in lower motor neuron diseases as compared to other MND. CSF concentrations of S100beta and sCD14 correlated with the survival time in patients with ALS. In motor neuron diseases, CSF tau elevation indicates the degeneration of upper motor neurons, while S100 beta and sCD14 may indicate the activation of CNS glial cells. Because S100beta and sCD14 concentrations correlate with survival in amyotrophic lateral sclerosis (ALS), we suppose that the combination of both markers may be useful to obtain prognostic information in patients with ALS.

  4. Quality of general movements and the development of minor neurological dysfunction at toddler and school age

    NARCIS (Netherlands)

    Hadders-Algra, M; Mavinkurve-Groothuis, AMC; Stremmelaar, EF; Martijn, A; Butcher, PR; Groen, S.E

    Objective: To evaluate the reliability of assessing infants' general movements (GMs) using a new classification and its validity in predicting complex minor neurological dysfunction (MND) at toddler and at school age. Design: Prospective study of two groups of infants, each consisting of a mix of

  5. TDP-43 in Familial and Sporadic Frontotemporal Lobar Degeneration with Ubiquitin Inclusions

    NARCIS (Netherlands)

    Cairns, Nigel J.; Neumann, Manuela; Bigio, Eileen H.; Holm, Ida E.; Troost, Dirk; Hatanpaa, Kimmo J.; Foong, Chan; White, Charles L.; Schneider, Julie A.; Kretzschmar, Hans A.; Carter, Deborah; Taylor-Reinwald, Lisa; Paulsmeyer, Katherine; Strider, Jeffrey; Gitcho, Michael; Goate, Alison M.; Morris, John C.; Mishrall, Manjari; Kwong, Linda K.; Stieber, Anna; Xu, Yan; Forman, Mark S.; Trojanowski, John Q.; Lee, Virginia M.-Y.; Mackenzie, Ian R. A.

    2007-01-01

    TAR DNA-binding protein 43 (TDP-43) is a major pathological protein of sporadic and familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions (FTLD-U) with or without motor neuron disease (MND). Thus, TDP-43 defines a novel class of neurodegenerative diseases called

  6. Implicitly Defined Neural Networks for Sequence Labeling

    Science.gov (United States)

    2017-07-31

    ularity has soared for the Long Short - Term Memory (LSTM) (Hochreiter and Schmidhuber, 1997) and vari- ants such as Gated Recurrent Unit (GRU) (Cho et...610. Sepp Hochreiter and Jürgen Schmidhuber. 1997. Long short - term memory . Neural computation 9(8):1735– 1780. Zhiheng Huang, Wei Xu, and Kai Yu. 2015...network are coupled together, in order to improve perfor- mance on complex, long -range dependencies in either direction of a sequence. We contrast our

  7. Majaraamatud - ühtne tervik ja väärikalt hoitud detailid / Yoko Alender

    Index Scriptorium Estoniae

    Alender, Yoko, 1979-

    2011-01-01

    Tutvustus: Tallinna maja : hoonetüübi areng ja säästev uuendamine / koostanud Mark Sepp ja Tallinna Kultuuriväärtuste Amet. Tallinn, 2010; Lenderi maja : hoonetüübi areng ja säästev uuendamine / koostanud Anni Martin ja Tallinna Kultuuriväärtuste Amet. Tallinn, 2009; Funktsionalistlik maja : eramu ja väike kortermaja / koostanud Monika Eensalu ja Tallinna Kultuuriväärtuste Amet. Tallinn, 2011. Vanade majade säilitamisest

  8. Radio Model-free Noise Reduction of Radio Transmissions with Convolutional Autoencoders

    Science.gov (United States)

    2016-09-01

    as a front end to a long short term memory (LSTM) [12], which may provide another route towards understanding the content or meaning of RF emissions...Exploring Engineering™ (IJITEE) 2:6–9. 12. Sepp Hochreiter and Jurgen Schmidhuber. 1007. “Long Short - term Memory , Neural Computation 9(8):1735–1780. 13...the noisy channel capacity , with no further optimizations. 2 2. METHODS AND EXPERIMENT We will use the terms instance or example to refer to a

  9. LAPSENA SEKSUAALISESTI HYVÄKSIKÄYTETTYJEN NAISTEN KOKEMUKSIA VOIMAANTUMISESTA : Elämän pituinen matka

    OpenAIRE

    Seppänen, Suvi

    2011-01-01

    Lapsena seksuaalisesti hyväksikäytettyjen naisten kokemuksia voimaantumisesta–Elämän pituinen matka. Opinnäytetyö, 64 sivua, liitteitä 5. Suvi Seppänen, Diakonia-ammattikorkeakoulu, Diak Pohjoinen, Oulu, syksy 2011. Hoitotyön koulutusohjelma, diakonisen hoitotyön suuntautumisvaihtoehto, sairaanhoitaja (AMK) – diakonissa. Suomen Delfins Ry on valtakunnallinen tukijärjestö seksuaalisesti hyväksikäytetyille ihmisille. Järjestön tukemia vertaistukiryhmiä toimii eri puolilla Suomea. Lupa tutki...

  10. Eelmine aasta andis palju häid uusehitisi / Heli Salong

    Index Scriptorium Estoniae

    Salong, Heli, 1958-

    2003-01-01

    Analüüsitakse Kuressaares aasta jooksul valminud ehitusi, sisekujundust ja reklaamisilte. Parimateks tunnistas žürii koosseisus Lilian Hansar, Urmas Sepp, Endla Tuutma, Vello Liiv, Ainar Viires, Tuuli Org, Terje Truumaa, Sulev Vahtre, Urmas Arike ja Rita Tamm ärihoone Ferrumi (Arhitektuuribüroo Alver Trummal Arhitektid), Kohvik-Veski laienduse (projekt Tuuli Org), eramu Tulika 5 (projekt Kiira Soosaar), pansionaadi Uus-Roomassaare 5 ruumikujunduse (kujundaja Vello Liiv) ja raamatukogu infokeskuse reklaamisildi (kujundaja AB Studio 3)

  11. Risk factors for motor neuron diseases : genes, environment and lifestyle

    NARCIS (Netherlands)

    Sutedja, N.A.

    2010-01-01

    The main focus of this thesis is to identify susceptibility factors in diseases affecting the motor neuron: both motor neuron disease (MND), in which primarily the cell body is affected, and multifocal motor neuropathy (MMN), in which primarily the axon is affected, are covered. Due to its

  12. Rare genetic variation in UNC13A may modify survival in amyotrophic lateral sclerosis

    NARCIS (Netherlands)

    Gaastra, Benjamin; Shatunov, Aleksey; Pulit, Sara; Jones, Ashley R; Sproviero, William; Gillett, Alexandra; Chen, Zhongbo; Kirby, Janine; Fogh, Isabella; Powell, John F; Leigh, P Nigel; Morrison, Karen E; Shaw, Pamela J; Shaw, Christopher E; van den Berg, Leonard H; Veldink, Jan H; Lewis, Cathryn M; Al-Chalabi, Ammar

    2016-01-01

    Our objective was to identify whether rare genetic variation in amyotrophic lateral sclerosis (ALS) candidate survival genes modifies ALS survival. Candidate genes were selected based on evidence for modifying ALS survival. Each tail of the extreme 1.5% of survival was selected from the UK MND DNA

  13. The Genetics of Monogenic Frontotemporal Dementia

    Directory of Open Access Journals (Sweden)

    Leonel T. Takada

    Full Text Available ABSTRACTAround 10-15% of patients diagnosed with frontotemporal dementia (FTD have a positive family history for FTD with an autosomal dominant pattern of inheritance. Since the identification of mutations in MAPT(microtubuleassociated protein tau gene in 1998, over 10 other genes have been associated with FTD spectrum disorders, discussed in this review. Along with MAPT, mutations in GRN(progranulin and C9orf72(chromosome 9 open reading frame 72 are the most commonly identified in FTD cohorts. The association of FTD and motor neuron disease (MND can be caused by mutations in C9orf72and other genes, such as TARDBP(TAR DNA-binding protein, FUS(fused in sarcoma, UBQLN2(ubiquilin 2. Multisystem proteinopathy is a complex phenotype that includes FTD, Paget disease of the bone, inclusion body myopathy and MND, and can be due to mutations in VCP(valosing containing protein and other recently identified genes.

  14. Design and implementation of a hybrid MPI-CUDA model for the Smith-Waterman algorithm.

    Science.gov (United States)

    Khaled, Heba; Faheem, Hossam El Deen Mostafa; El Gohary, Rania

    2015-01-01

    This paper provides a novel hybrid model for solving the multiple pair-wise sequence alignment problem combining message passing interface and CUDA, the parallel computing platform and programming model invented by NVIDIA. The proposed model targets homogeneous cluster nodes equipped with similar Graphical Processing Unit (GPU) cards. The model consists of the Master Node Dispatcher (MND) and the Worker GPU Nodes (WGN). The MND distributes the workload among the cluster working nodes and then aggregates the results. The WGN performs the multiple pair-wise sequence alignments using the Smith-Waterman algorithm. We also propose a modified implementation to the Smith-Waterman algorithm based on computing the alignment matrices row-wise. The experimental results demonstrate a considerable reduction in the running time by increasing the number of the working GPU nodes. The proposed model achieved a performance of about 12 Giga cell updates per second when we tested against the SWISS-PROT protein knowledge base running on four nodes.

  15. Rahvusvaheline üldmeditsiini kongress oli Eestis esmakordselt / Marika Kusnets

    Index Scriptorium Estoniae

    Kusnets, Marika

    2007-01-01

    8. detsembril peeti Tallinnas rahvusvahelist üldmeditsiini kongressi, kus osalesid mitmete erialade arstid. Kongressil käsitletud teemad - südame-veresoonkonnahaiguste varajane diagnostika, söömisharjumused, metabolism, hüpertoonia, erektsioonihäired, depressioon, 2. tüüpi diabeet ja oftalmoloogia

  16. Tammsaare-aastat ilmestavad ka raamatud / Marika Rajamäe

    Index Scriptorium Estoniae

    Rajamäe, Marika, 1952-

    2008-01-01

    Tammsaare muuseumis esitleti kahte raamatut: Tammsaare, Anton Hansen. Siin mägi, seal mägi... Anton Hansen Tammsaare oma koduloodusest : fotoalbum (koostanud Ann Marvet. Tallinn : Huma, 2008) ja Liivak, Age-Li. Tammsaare kirjanduspreemia laureaadid Hugo Hiibuse sulega. (Türi : Saarakiri, 2008)

  17. Ulila perearst jääb alles / Marika Tuus

    Index Scriptorium Estoniae

    Tuus, Marika, 1951-

    2006-01-01

    Riigikogu sotsiaalkomisjoni liige juhtumist, kus Puhja vallavalitsus kavatses Ulilas perearsti koha kaotada, aga parlamendiliikme ja sotsiaalministeeriumi sekkumisel saab Ulila perearst oma tööd jätkata. Sotsiaalministeeriumis valminud seaduseelnõust, mis ei kohusta perearsti olema ettevõtja

  18. Vest-Wood pürgib Balti turule / Marika Tomberg

    Index Scriptorium Estoniae

    Tomberg, Marika

    2004-01-01

    Ilmunud ka: Äripäev : Eesti Edukamad Ettevõtted : Maakondlikud edetabelid Top 100, 26. nov. 2004, lk. 15. TOP-i 1. koht. Uksetootja Vest-Woodi konkurentsieeliseks on väga hea töökorraldus. Diagramm

  19. Richard Avedon ja Annie Leibovitz laulsid kaanonit / Marika Alver

    Index Scriptorium Estoniae

    Alver, Marika

    2008-01-01

    Richard Avedoni (1923-2004) retrospektiivnäitusest (fotod aastatest 1946-2004) kuraator Helle Crenzien (Lousiana Kaasaegse Kunsti muuseum Taanis), millega kaasnes ka Helen Whitney film "Richard Avedon : darkness and light" ja Annie Leibovitzi (1949) suurprojektist "A photographer's life 1990-2005" Pariisis

  20. An Exploratory Study of Software Cost Estimating at the Electronic Systems Division.

    Science.gov (United States)

    1976-07-01

    action’. to improve the software cost Sestimating proces., While thin research was limited to the M.nD onvironment, the same types of problema may exist...Methods in Social Science. Now York: Random House, 1969. 57. Smith, Ronald L. Structured Programming Series (Vol. XI) - Estimating Software Project

  1. A Framework for Failure? The Impact of Short Tour Lengths and Separate National Command and Control on British Operational Art and Coalition Warfare in Iraq, 2003-2009

    Science.gov (United States)

    2013-12-10

    frame the problem.54 This is a clear example of cognitive dissonance and highlights the intellectual confusion that had emerged in senior British...to explicitly express complete satisfaction with PJHQ and the command and control framework) came from LTG Riley, CG MND (SE) from Dec 04-Jun 05: LTG

  2. Studies on motor neuron disease with cranial magnetic resonance imaging

    International Nuclear Information System (INIS)

    Mitsui, Yoshiyuki; Takahashi, Mitsuo; Nakamura, Yusaku; Kitaguchi, Masataka; Yagi, Yuji

    1992-01-01

    The present study was performed to examine the pyramidal tracts of the brain in both 51 normal subjects (21 male and 30 female subjects; mean age of 43.5±16.1 years) and 12 patients with motor neuron disease (6 male and 6 female patients; mean age of 57.4±7.9 years), using the magnetic resonance imaging (MRI). The 12 patients with motor neuron disease (MND) comprised 7 suffering from spinal progressive muscular atrophy (SPMA) and 5 from amyotrophic lateral sclerosis (ALS). The MRI used in this study was of both short spin echo and long spin echo sequence. Of the 52 normal subjects, 24 of them (47%) had the T2 prolonged small areas (high signal intensity areas) at the posterior limb of internal capsule. These findings were not found in the normal subjects over fifty years old. No similar finding was detected in the pyramidal tracts except the posterior limb of internal capsule. On the other hand, 8 patients with MND (67%) proved to have the high signal intensity areas in the pyramidal tracts. Moreover, these high intensity areas were extended from the crus cerebri to corona radiata in 7 patients (58%). In all patients with ALS, these areas were extended in whole areas of the pyramidal tracts, and the similar findings were also found in two patients with SPMA. These findings were demonstrated to be more extensive than those in the normal subjects. The results thus obtained warrant us to conclude that cranial MRI is useful to detect the degeneration of the pyramidal tracts of MND patients. (author)

  3. Zur Interaktion von Genotyp und Ernährung bei Darmkrebs

    OpenAIRE

    Behrends, Thomas

    2013-01-01

    Ziel dieser Arbeit war es, sowohl die Auswirkungen einer veränderten Selenversorgung über die Nahrung als auch die Rolle des zentralen Transport- und Speicherproteins für Selen (Selenoprotein P, SepP) auf die intestinale Tumorigenese tierexperimentell zu untersuchen. Eine gestörte SepP-Expression, führte zur Ausbildung größerer Tumore. Durch eine Steigerung der Selenversorgung über die Nahrung eine signifikante Reduktion von Tumoranzahl und Gesamttumorfläche erzielt werden. Hierzu wurde den ...

  4. President Ilves sarjas hoogtöö korras seaduste tegemist / Tuuli Koch

    Index Scriptorium Estoniae

    Koch, Tuuli

    2010-01-01

    President Toomas Hendrik Ilvese kõnest iseseisvuspäeval. Arvamust avaldavad justiitsminister Rein Lang, Riigikogu põhiseaduskomisjoni esimees Väino Linde ja komisjoni aseesimees Evelyn Sepp, sotsiaalminister Hanno Pevkur ning haridus- ja teadusminister Tõnis Lukas. Presidendi vastuvõtu kujundust ja kontserti hindavad lilleseadja Taivo Piller, muusikakriitik Margus Haav ja Rakvere teatri peanäitejuht Üllar Saaremäe. Küsimustele vastab presidendi vastuvõtu teleülekande produtsent Margus Saar. Juuresoleval fotol justiitsminister Rein Lang presidendi kätlemistseremoonial

  5. Eesti teatri aastaauhinnad 2006. aasta loomingu eest

    Index Scriptorium Estoniae

    2007-01-01

    Elmo Nüganen - lavastajaauhind, Ene-Liis Semper - kunstniku auhind, Hele Kõre - naisnäitleja auhind, Lembit Ulfsak - meesnäitleja auhind, Evelin Pang - naiskõrvalosa auhind, Margus Prangel - meeskõrvalosa auhind, Oleg Titov - draamalavastuse eriauhind, Helen Lokuta ja Lauri Sirp - muusikalavastuse auhind, Michiel Dijkema - muusikalavastuse eriauhind, Mare Tommingas - balletilavastuse auhind, ZUGA ühendatud tantsijad - tantsulavastuse auhind, Margus Mikomägi - kriitikaauhind, Tiit Sukk - Ants Lauteri näitlejaauhind, Ingomar Vihmar - Ants Lauteri lavastajaauhind, Rauno Elp - Georg Otsa auhind, Aare Toikka - Salme Reegi auhind, Reet Aus - Natalie Mei auhind, Anu Lamp - Priit Põldroosi auhind, Peeter Sauter - Aleksander Kurtna auhind, Artjom Maksakov ja Natalja Popenko - Kristallkingakese auhind, Enar Tarmo, Hendrik Kiisler ja Marika Tint - tehnilise töötaja auhind

  6. Eesti teatri aastaauhinnad 2006

    Index Scriptorium Estoniae

    2007-01-01

    Elmo Nüganen - lavastajaauhind, Ene-Liis Semper - kunstniku auhind, Hele Kõre - naisnäitleja auhind, Lembit Ulfsak - meesnäitleja auhind, Evelin Pang - naiskõrvalosa auhind, Margus Prangel - meeskõrvalosa auhind, Oleg Titov - draamalavastuse eriauhind, Helen Lokuta ja Lauri Sirp - muusikalavastuse auhind, Michiel Dijkema - muusikalavastuse eriauhind, Mare Tommingas - balletilavastuse auhind, ZUGA ühendatud tantsijad - tantsulavastuse auhind, Margus Mikomägi - kriitikaauhind, Tiit Sukk - Ants Lauteri näitlejaauhind, Ingomar Vihmar - Ants Lauteri lavastajaauhind, Rauno Elp - Georg Otsa auhind, Aare Toikka - Salme Reegi auhind, Reet Aus - Natalie Mei auhind, Anu Lamp - Priit Põldroosi auhind, Peeter Sauter - Aleksander Kurtna auhind, Artjom Maksakov ja Natalja Popenko - Kristallkingakese auhind, Enar Tarmo, Hendrik Kiisler ja Marika Tint - tehnilise töötaja auhind

  7. Millimeter Wave Attenuation in Moist Air: Laboratory Measurements and Analysis.

    Science.gov (United States)

    1984-03-01

    generation of incoherent noise, Mnd wavelengths. (e) scintillitions due to random fluctuations of the medium in space and time. The array of mathematical ...calculations are for observations in the zenith direction free air is very empty. The molecular radius r -1.5 x ICI-4 Lem. groud lvel Coaic aditio of

  8. LGBTQ Inclusion in Educator Preparation: Getting Ready for Gender and Sexual Diversity in Secondary School Settings

    Science.gov (United States)

    Hoelscher, Mary Helen

    While many lesbian, gay, bisexual, transgender, and queer (LGBTQ) students are able to resiliently navigate their public school education many others experience harsh school climates and negative health and educational outcomes. Harassment and bullying of LGBTQ students in school environments have been linked to numerous negative psychological and academic outcomes for students diverse in sexual orientation and/or gender identity. Preparing teacher candidates (TCs) to respond effectively to harassment and bullying of students and to create inclusive curriculum has been recommended to improve outcomes for students. Yet the development of these teaching practices has not been pursued broadly in educator preparation programs (EPPs) or specifically in science EPPs (SEPPs). This dissertation broadens the notion of diversity traditionally attended to in EPPs through three studies. The first study is a holistic single-case study of an LGBTQ-inclusive EPP. It focused on the following three research questions: What were the contextual features that surrounded the LGBTQ-inclusive EPP? What were the specific elements of LGBTQ inclusion in the EPP? And, what were the strengths and weaknesses of the LGBTQ-inclusive EPP? This study drew primarily from data collected from interviews with faculty and administrators in a large post-baccalaureate 5th year preparation for licensure program. Document analysis was used to triangulate and expand upon the data collected during the interviews. A framework for analyzing LGBTQ inclusion across the components of an EPP was developed as part of this study. This study has direct implications for the particular EPP, but also clarifies research needs around LGBTQ inclusion in secondary EPPs. While little has research exists about LGBTQ inclusion in EPPs, far less has been attempted and understood in the discipline of secondary life science. The second study thus narrows its focus from the particulars of LGBTQ inclusion in an EPP to the

  9. Amyotrophic lateral sclerosis presenting with orthopnea in a patient with COPD and obstructive sleep apnea

    Directory of Open Access Journals (Sweden)

    T.L.N. Swamy

    2011-01-01

    Full Text Available Amyotrophic lateral sclerosis (ALS, also known as motor neuron disease (MND is a relentlessly progressive neurological disorder causing peripheral muscular weakness and resultant respiratory failure. In this article, we report a case of ALS with chronic obstructive pulmonary disease (COPD and obstructive sleep apnea (OSA with orthopnea as initial symptoms.

  10. Review of Indigenous Health Curriculum in Nutrition and Dietetics at One Australian University: An Action Research Study

    Science.gov (United States)

    Wilson, Annabelle M.; Mehta, Kaye; Miller, Jacqueline; Yaxley, Alison; Thomas, Jolene; Jackson, Kathryn; Wray, Amanda; Miller, Michelle D.

    2015-01-01

    This article describes a review undertaken in 2012-2013 by Nutrition and Dietetics, Flinders University, to assess the Indigenous health curriculum of the Bachelor of Nutrition and Dietetics (BND) and Masters of Nutrition and Dietetics (MND). An action research framework was used to guide and inform inquiry. This involved four stages, each of…

  11. Mutant ApoA-1 Amyloidosis in a Family of Five Siblings With Motor Neuron Disease and Dementia

    DEFF Research Database (Denmark)

    Vrethema, Magnus; Mucchiano, Gerd Ingrid

    2011-01-01

    We present a family of fi ve siblings in which three brothers died of motor neuron disease (MND) and in two of them concomitant with dementia. A fourth brother died of myocardial infarction and was found to have extensive aortic intimal apolipoprotein A-1 (ApoA-1) derived amyloid deposits and apo...

  12. Handwriting, Visuomotor Integration, and Neurological Condition at School Age

    Science.gov (United States)

    Van Hoorn, Jessika F.; Maathuis, Carel G. B.; Peters, Lieke H. J.; Hadders-Algra, Mijna

    2010-01-01

    Aim: The study investigated the relationships between handwriting, visuomotor integration, and neurological condition. We paid particular attention to the presence of minor neurological dysfunction (MND). Method : Participants were 200 children (131 males, 69 females; age range 8-13y) of whom 118 received mainstream education (mean age 10y 5mo, SD…

  13. 10 aastat kostüümidraamat / Kaire Raave, Katrin Pauts, Kaja Roomets

    Index Scriptorium Estoniae

    Raave, Kaire

    2007-01-01

    Oma rõivastusest vabariigi aastapäeva presidendi vastuvõttudel räägivad Eesti Kunstiakadeemia rektor Signe Kivi, dirigent Eri Klasi abikaasa Ariel, Riigikogu liige Evelyn Sepp, tippärimehe Urmas Sõõrumaa kaasa Kätlin Maran ja Võru linnapea Ivi Eenmaa. Lisatud valik fotosid presidendi vastuvõttudest aastatel 1999-2006. Vt. samas: President Toomas Hendrik Ilves 9 aastat presidendi vastuvõtul. Pikemalt Signe Kivi kleitidest ja näitusest "24. veebruar" Disaini- ja Arhitektuurigaleriis, kus on eksponeeritud tema kõiki vastuvõttudel kantud kleite

  14. Reporting of lipidomics data should be standardized

    DEFF Research Database (Denmark)

    Liebisch, Gerhard; Ekroos, Kim; Hermansson, Martin

    2017-01-01

    This article highlights, to our opinion, some of the most pertinent issues related to producing high quality lipidomics data. These issues include pitfalls related to sample collection and storage, lipid extraction, the use of shotgun and LC-MS-based lipidomics approaches, and the identification......, annotation and quantification of lipid species. We hope that highlighting these issues will help stimulate efforts to implement reporting standards for dissemination of lipidomics data. This article is part of a Special Issue entitled: BBALIP_Lipidomics Opinion Articles edited by Sepp Kohlwein....

  15. Kas Eestil on lootust? / Jüri Sepp, Erik Terk

    Index Scriptorium Estoniae

    Sepp, Jüri, 1952-

    2007-01-01

    Autorid vaatlevad mitmete edetabelite põhjal, kuidas Eestil on läinud teiste riikidega võrreldes, ning nimetavad probleeme Eesti edasiliikumisel. Nende hinnangul ei seisne Eesti ühiskonna tulevikuprobleem mitte selles, kas ohverdada sotsiaalsust liberaalsusele või vastupidi, vaid selles, kuidas neid kahte asja ühendada. Artikli alus on "Eesti inimarengu aruanne 2006"

  16. Kas Eestil on lootust? / Jüri Sepp, Erik Terk

    Index Scriptorium Estoniae

    Sepp, Jüri, 1952-

    2012-01-01

    Autorid vaatlevad mitmete edetabelite põhjal, kuidas Eestil on läinud teiste riikidega võrreldes, ning nimetavad probleeme Eesti edasiliikumisel. Nende hinnangul ei seisne Eesti ühiskonna tulevikuprobleem mitte selles, kas ohverdada sotsiaalsust liberaalsusele või vastupidi, vaid selles, kuidas neid kahte asja ühendada. Artikli alus on "Eesti inimarengu aruanne 2006"

  17. salmepaat.blogspot.com vahendab muistsete saladuste paljastamist / Andres Sepp

    Index Scriptorium Estoniae

    Sepp, Andres

    2008-01-01

    Saaremaalt Salmelt leitud muinaspaadi uurimistööde tulemuste avalikustamiseks lõid arheoloogid Eestis spetsiaalse blogi. Konservaator Aive Rumm Tallinna Ülikooli Ajaloo Instituudist teeb blogis kokkuvõtte Salme muinaslaevast pärit metallesemete seisukorrast ning nende konserveerimise viisidest

  18. Tuul võib hakata Saaremaale elektrit andma / Andres Sepp

    Index Scriptorium Estoniae

    Sepp, Andres, 1976-

    2001-01-01

    Taani kapitalil põhinev OÜ Roomapark asub uurima, kas investeerida sadu miljoneid kroone Kuressaare lähistele Roomassaare poolsaarele tuulegeneraatorite püstitamiseks. Taani kontsern World Wide Wind (WWW)

  19. Kuidas tõlkida loojaid riigiametnikele ja vastupidi? / Andreas Sepp

    Index Scriptorium Estoniae

    Sepp, Andreas

    2010-01-01

    Oktoobris 2010 toimus Tallinna Ülikooli Balti Filmi- ja Meediakooli korraldatud loengusari "Creative and Cultural Industries Policy in Europe", kus keskenduti Euroopa Liidu loomemajanduse regulatiivpoliitikale. Kursuse viisid läbi õppejõud Bernd Hartmann ja Jan Runge Saksamaalt

  20. Lauluväljaku uus skulptuur visualiseerib heli / Andreas Sepp

    Index Scriptorium Estoniae

    Sepp, Andreas

    2011-01-01

    14. mail Tallinna lauluväljakul Euroopa kultuuripealinna segakoori kontserdiga avatavast saksa skulptori Lukas Kühne loodud akustilisest skulptuurist "Chromatico". Teose arhitekt on Rosario Nuin (Uruguay), ehitas Nordecon Betoon

  1. Kas Tallinn vajab uut brändi? / Andreas Sepp

    Index Scriptorium Estoniae

    Sepp, Andreas

    2010-01-01

    Tallinnas viibinud saksa loomemajanduse õppejõudude Bernd Hartmanni ja Jan Runge sõnul on kultuuripealinna aasta hea võimalus linnakuvandi parandamiseks. Nende arvates võiks Tallinn kultuuripealinna raames anda noortele disaineritele ja filmitegijatele loomingu eksponeerimiseks piisavalt võimalusi ning keskenduda kohaliku kultuurielu parandamisele

  2. Transition from the adiabatic to the sudden limit in core-electron photoemission

    Science.gov (United States)

    Hedin, Lars; Michiels, John; Inglesfield, John

    1998-12-01

    Experimental results for core-electron photoemission Jk(ω) are often compared with the one-electron spectral function Ac(ɛk-ω), where ω is the photon energy, ɛk is the photoelectron energy, and the optical transition matrix elements are taken as constant. Since Jk(ω) is nonzero only for ɛk>0, we must actually compare it with Ac(ɛk-ω)θ(ɛk). For metals Ac(ω) is known to have a quasiparticle (QP) peak with an asymmetric power-law [theories of Mahan, Nozières, de Dominicis, Langreth, and others (MND)] singularity due to low-energy particle-hole excitations. The QP peak starts at the core-electron energy ɛc, and is followed by an extended satellite (shakeup) structure at smaller ω. For photon energies ω just above threshold, ωth=-ɛc, Ac(ɛk-ω)θ(ɛk) as a function of ɛk (ω constant) is cut just behind the quasiparticle peak, and neither the tail of the MND line nor the plasmon satellites are present. The sudden (high-energy) limit is given by a convolution of Ac(ω) and a loss function, i.e., by the Berglund-Spicer two-step expression. Thus Ac(ω) alone does not give the correct photoelectron spectrum, neither at low nor at high energies. We present an extension of the quantum-mechanical (QM) models developed earlier by Inglesfield, and by Bardyszewski and Hedin to calculate Jk(ω). It includes recoil and damping, as well as shakeup effects and extrinsic losses, is exact in the high-energy limit, and allows calculations of Jk(ω) including the MND line and multiple plasmon losses. The model, which involves electrons coupled to quasibosons, is motivated by detailed arguments. As an illustration we have made quantitative calculations for a semi-infinite jellium with the density of aluminum metal and an embedded atom. The coupling functions (fluctuation potentials) between the electron and the quasibosons are related to the random-phase-approximation dielectric function, and different levels of approximations are evaluated numerically. The differences

  3. Influence of extractable soil manganese on oxidation capacity of different soils in Korea

    Science.gov (United States)

    Chon, Chul-Min; Kim, Jae Gon; Lee, Gyoo Ho; Kim, Tack Hyun

    2008-08-01

    We examined the relationship between soil oxidation capacity and extractable soil manganese, iron oxides, and other soil properties. The Korean soils examined in this study exhibited low to medium Cr oxidation capacities, oxidizing 0.00-0.47 mmol/kg, except for TG-4 soils, which had the highest capacity for oxidizing added Cr(III) [>1.01 mmol/kg of oxidized Cr(VI)]. TG and US soils, with high Mn contents, had relatively high oxidation capacities. The Mn amounts extracted by dithionite-citrate-bicarbonate (DCB) (Mnd), NH2OH·HCl (Mnh), and hydroquinone (Mnr) were generally very similar, except for the YS1 soils, and were well correlated. Only small proportions of either total Mn or DCB-extractable Mn were extracted by NH2OH·HCl and hydroquinone in the YS1 soils, suggesting inclusion of NH2OH·HCl and hydroquinone-resistant Mn oxides, because these extractants are weaker reductants than DCB. No Cr oxidation test results were closely related to total Mn concentrations, but Mnd, Mnh, and Mnr showed a relatively high correlation with the Cr tests ( r = 0.655-0.851; P Mnh were better correlated with the Cr oxidation tests than was the Mnr concentration, suggesting that the oxidation capacity of our soil samples can be better explained by Mnd and Mnh than by Mnr. The first component in principal components analysis indicated that extractable soil Mn was a main factor controlling net Cr oxidation in the soils. Total soil Mn, Fe oxides, and the clay fraction are crucial for predicting the mobility of pollutants and heavy metals in soils. The second principal component indicated that the presence of Fe oxides in soils had a significant relationship with the clay fraction and total Mn oxide, and was also related to heavy-metal concentrations (Zn, Cd, and Cu, but not Pb).

  4. Age-Related Uptake of Heavy Metals in Human Spinal Interneurons.

    Directory of Open Access Journals (Sweden)

    Roger Pamphlett

    Full Text Available Toxic heavy metals have been implicated in the loss of spinal motoneurons in amyotrophic lateral sclerosis/motor neuron disease (ALS/MND. Motoneuron loss in the spinal anterior horn is severe in ALS/MND at the time of death, making this tissue unsuitable for examination. We therefore examined spinal cords of people without muscle weakness to look for any presence of heavy metals that could make these neurons susceptible to damage. Spinal cord samples from 50 individuals aged 1-95 y who had no clinical or histopathological evidence of spinal motoneuron loss were studied. Seven μm formalin-fixed paraffin-embedded sections were stained for heavy metals with silver nitrate autometallography (AMGHM which detects intracellular mercury, silver or bismuth. Neurons in the spinal cord were classified as interneurons or α-motoneurons based on their site and cell body diameter. Spinal interneurons containing heavy metals were present in 8 of 24 people (33% aged 61-95 y, but not at younger ages. These AMGHM interneurons were most numerous in the lumbar spinal cord, with moderate numbers in the caudal cervical cord, few in the rostral cervical cord, and almost none in the thoracic cord. All people with AMGHM interneurons had occasional AMGHM staining in α-motoneurons as well. In one man AMGHM staining was present in addition in dorsomedial nucleus and sensory neurons. In conclusion, heavy metals are present in many spinal interneurons, and in a few α-motoneurons, in a large proportion of older people. Damage to inhibitory interneurons from toxic metals in later life could result in excitotoxic injury to motoneurons and may underlie motoneuron injury or loss in conditions such as ALS/MND, multiple sclerosis, sarcopenia and calf fasciculations.

  5. Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.

    Science.gov (United States)

    Baldauf, Hanna-Mari; Stegmann, Lena; Schwarz, Sarah-Marie; Ambiel, Ina; Trotard, Maud; Martin, Margarethe; Burggraf, Manja; Lenzi, Gina M; Lejk, Helena; Pan, Xiaoyu; Fregoso, Oliver I; Lim, Efrem S; Abraham, Libin; Nguyen, Laura A; Rutsch, Frank; König, Renate; Kim, Baek; Emerman, Michael; Fackler, Oliver T; Keppler, Oliver T

    2017-03-07

    Early after entry into monocytes, macrophages, dendritic cells, and resting CD4 T cells, HIV encounters a block, limiting reverse transcription (RT) of the incoming viral RNA genome. In this context, dNTP triphosphohydrolase SAM domain and HD domain-containing protein 1 (SAMHD1) has been identified as a restriction factor, lowering the concentration of dNTP substrates to limit RT. The accessory lentiviral protein X (Vpx) proteins from the major simian immunodeficiency virus of rhesus macaque, sooty mangabey, and HIV-2 (SIVsmm/SIVmac/HIV-2) lineage packaged into virions target SAMHD1 for proteasomal degradation, increase intracellular dNTP pools, and facilitate HIV cDNA synthesis. We find that virion-packaged Vpx proteins from a second SIV lineage, SIV of red-capped mangabeys or mandrills (SIVrcm/mnd-2), increased HIV infection in resting CD4 T cells, but not in macrophages, and, unexpectedly, acted in the absence of SAMHD1 degradation, dNTP pool elevation, or changes in SAMHD1 phosphorylation. Vpx rcm/mnd-2 virion incorporation resulted in a dramatic increase of HIV-1 RT intermediates and viral cDNA in infected resting CD4 T cells. These analyses also revealed a barrier limiting HIV-1 infection of resting CD4 T cells at the level of nuclear import. Single amino acid changes in the SAMHD1-degrading Vpx mac239 allowed it to enhance early postentry steps in a Vpx rcm/mnd-2-like fashion. Moreover, Vpx enhanced HIV-1 infection of SAMHD1-deficient resting CD4 T cells of a patient with Aicardi-Goutières syndrome. These results indicate that Vpx, in addition to SAMHD1, overcomes a previously unappreciated restriction for lentiviruses at the level of RT that acts independently of dNTP concentrations and is specific to resting CD4 T cells.

  6. The Effects of Motor Neurone Disease on Language: Further Evidence

    Science.gov (United States)

    Bak, Thomas H.; Hodges, John R.

    2004-01-01

    It might sound surprising that Motor Neurone Disease (MND), regarded still by many as the very example of a neurodegenerative disease affecting selectively the motor system and sparing the sensory functions as well as cognition, can have a significant influence on language. In this article we hope to demonstrate that language dysfunction is not…

  7. Synthèse: Revue des Sciences et de la Technologie - Vol 17 (2008)

    African Journals Online (AJOL)

    Modélisation numérique d'un phénomène mécanique (TRIP) induit par une transformation martensitique dans l'acier 16MND5 · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. S Mefta, L Taleb, F Barbe, F Sidoroff, 73-84 ...

  8. Mechanical cough augmentation techniques in amyotrophic lateral sclerosis/motor neuron disease

    OpenAIRE

    Rafiq, M.K.; Bradburn, M.; Mustfa, N.; Mcdermott, C.J.; Annane, D.

    2016-01-01

    © 2016 The Cochrane Collaboration.This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects of mechanical insufflator/exsufflator (MI-E) and the breath-stacking technique for reducing morbidity and mortality and enhancing quality of life in people with amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND).

  9. [History of hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P)].

    Science.gov (United States)

    Takashima, Hiroshi

    2013-01-01

    We established a new disease autosomal dominant hereditary motor and sensory neuropathy with proximal dominant involvement (HMSNP) in 1997, in Okinawa, Japan. This disease is characterized by proximal dominant neurogenic atrophy with fasciculations, painful muscle cramp, obvious sensory nerve involvement, areflexia, high incidence of elevated creatine kinase levels, hyperlipidemia and hyperglycemia. (MIM %604484). HMSNP is so called or HMSNO (HMSN OKINAWA type),. These clinical features resembled those of Kennedy-Alter-Sung syndrome. Most HMSNP patients have severe muscle atrophy and finally the tracheostomy and artificial ventilation are required. Therefore, we initially thought to classify HMSNP into a subtype of motor neuron disease (MND) like familial amyotrophic lateral sclerosis (FALS) or spinal muscular atrophy (SMA). However, the general consensus for MND was no sensory involvement. Therefore, as the disease showed severe sensory involvement, we categorized HMSNP in subtype of HMSN at that time. We also reported the pathology of HMSNP, showing severely decreased anterior horn cells, decreased posterior horn cells, and loss of posterior funiculus in the spinal cord.

  10. Therapeutic opportunities and challenges of induced pluripotent stem cells-derived motor neurons for treatment of amyotrophic lateral sclerosis and motor neuron disease

    Institute of Scientific and Technical Information of China (English)

    Manoj Kumar Jaiswal

    2017-01-01

    Amyotrophic lateral sclerosis (ALS) and motor neuron diseases (MNDs) are progressive neurodegenera-tive diseases that affect nerve cells in the brain affecting upper and lower motor neurons (UMNs/LMNs), brain stem and spinal cord.The clinical phenotype is characterized by loss of motor neurons (MNs), mus-cular weakness and atrophy eventually leading to paralysis and death due to respiratory failure within 3–5 years after disease onset. No effective treatment or cure is currently available that halts or reverses ALS and MND except FDA approved drug riluzole that only modestly slows the progression of ALS in some patients. Recent advances in human derived induced pluripotent stem cells have made it possible for the first time to obtain substantial amounts of human cells to recapitulate in vitro"disease in dish"and test some of the underlying pathogenetic mechanisms involved in ALS and MNDs. In this review, I discussed the opportunities and challenges of induced pluropotent stem cells-derived motor neurons for treatment of ALS and MND patients with special emphasis on their implications in finding a cure for ALS and MNDs.

  11. Therapeutic opportunities and challenges of induced pluripotent stem cells-derived motor neurons for treatment of amyotrophic lateral sclerosis and motor neuron disease.

    Science.gov (United States)

    Jaiswal, Manoj Kumar

    2017-05-01

    Amyotrophic lateral sclerosis (ALS) and motor neuron diseases (MNDs) are progressive neurodegenerative diseases that affect nerve cells in the brain affecting upper and lower motor neurons (UMNs/LMNs), brain stem and spinal cord. The clinical phenotype is characterized by loss of motor neurons (MNs), muscular weakness and atrophy eventually leading to paralysis and death due to respiratory failure within 3-5 years after disease onset. No effective treatment or cure is currently available that halts or reverses ALS and MND except FDA approved drug riluzole that only modestly slows the progression of ALS in some patients. Recent advances in human derived induced pluripotent stem cells have made it possible for the first time to obtain substantial amounts of human cells to recapitulate in vitro " disease in dish " and test some of the underlying pathogenetic mechanisms involved in ALS and MNDs. In this review, I discussed the opportunities and challenges of induced pluropotent stem cells-derived motor neurons for treatment of ALS and MND patients with special emphasis on their implications in finding a cure for ALS and MNDs.

  12. Teatri aastaauhindade laureaadid 2007

    Index Scriptorium Estoniae

    2007-01-01

    Elmo Nüganen - lavastajaauhind, Ene-Liis Semper - kunstniku auhind, Hele Kõre - naisnäitleja auhind, Lembit Ulfsak - meesnäitleja auhind, Evelin Pang - naiskõrvalosa auhind, Margus Prangel - meeskõrvalosa auhind, Oleg Titov - draamalavastuse eriauhind, Helen Lokuta ja Lauri Sirp - muusikalavastuse auhind, Michiel Dijkema - muusikalavastuse eriauhind, Mare Tommingas - balletilavastuse auhind, ZUGA ühendatud tantsijad - tantsulavastuse auhind, Margus Mikomägi - kriitikaauhind, Tiit Sukk - Ants Lauteri näitlejaauhind, Ingomar Vihmar - Ants Lauteri lavastajaauhind, Rauno Elp - Georg Otsa auhind, Aare Toikka - Salme Reegi auhind, Reet Aus - Natalie Mei auhind, Anu Lamp - Priit Põldroosi auhind, Peeter Sauter - Aleksander Kurtna auhind, Artjom Maksakov ja Natalja Popenko - Kristallkingakese auhind, Enar Tarmo, Hendrik Kiisler ja Marika Tint - tehnilise töötaja auhind. Ka Kuressaares toimunud teatripeost

  13. Rupther: a simulation approach applied to a PWR vessel failure during a severe accident

    International Nuclear Information System (INIS)

    Mongabure, Ph.; Nicolas, L.; Devos, J.

    2000-01-01

    The Rupther program (Rupture Under Thermal Conditions) is a part of the international researches on severe accidents in the PWR type reactors. The aim of the program is the definition of failure simulation validated by experimental data on vessel steel 16MND5 mechanical properties. The paper presents the program and the first results. (A.L.B.)

  14. Negotiating the Nation in History: the Swedish State Approval Scheme for Textbooks and Teaching Aids from 1945 to 1983

    Science.gov (United States)

    Elmersjö, Henrik Åström

    2016-01-01

    This article explores the discussions concerning history textbooks that occurred within the Swedish State Approval Scheme for Textbooks (Statens läroboksnämnd) from 1945 to 1983. By focusing on the negotiation of nationhood and the process of textbook approval as an arena for the renegotiation of ways in which history was taught in schools, the…

  15. Olika förklaringar till lägre straffnivåer i de nordiska länderna jämfört med övriga europeiska

    DEFF Research Database (Denmark)

    Bondeson, Ulla V.

    2007-01-01

    ). Both of us emphasize economic variables such as GDP and welfare expenditures, as well social inequality. I juxtapose political factors, referred to by Lappi-Seppälä as "consensual democracies" and "neo-corporativism", with the theory of " functional democracy". In regard to increasing rates......, though I stress that different formulations of the question produce different results. I argue against the common postulate of penal populism starting in the 1980s and point to the constancy of penal and other social attitudes over the decades, as demonstrated in my book, Nordic Moral Climates (2003...

  16. Maagiline Matrix - muutuste võti / Marika Makarova ; kommenteerinud Ainar Leppik

    Index Scriptorium Estoniae

    Makarova, Marika

    2010-01-01

    USA kiropraktiku Richard Bartletti loodud Matrix Energetics tehnikate alusl Ainar Leppiku poolt loodud Maagilise Maatriksi meetodist, mis õpetab muutuste toomist oma ellu. Vestlustest Maagilise Maatriksi õpetajatega

  17. Naistearstide ja neuroloogide kokkusaamine pakkus osapooltele suurt huvi / Marika Gordon

    Index Scriptorium Estoniae

    Gordon, Marika

    2010-01-01

    Eesti Naistearstide Seltsi ja L. Puusepa nimelise Eesti Neuroloogide ja Neurokirurgide Seltsi ühiskoosolekul kõneldi naiste ja meeste neurobioloogilistest iseärasustest, seksuaaleluhäiretest, rasedusaegsetest peavaludest, epilepsia ravist naistel ja sünnitusabist

  18. 400 miljoni eurone programm toetab innovaatilisi ettevõtteid / Marika Roomere

    Index Scriptorium Estoniae

    Roomere, Marika

    2007-01-01

    2007. aasta sügisel ellu kutsutud Euroopa ettevõtluse toetusprogrammist Eurostars, mille raames toetatakse keskmise suurusega ja väikeettevõtteid 400 miljoni euroga rahvusvahelise teadus- ja arendustegevusega tegelemiseks. Lisa: Mis on Eurostarsi programm?

  19. Leedu ettevõtteid ahvatleb Eesti turg / Gerli Ramler, Marika Roomere

    Index Scriptorium Estoniae

    Ramler, Gerli

    2007-01-01

    Mitmed Leedu ettevõtted on juba edukalt Eesti turule sisenenud ning oodata on uusi tegijaid. Leedu pitsarestoranide keti Cili ja Double Coffee Estonia plaanidest. Vt. samas: Toiduliidu juhataja Sirje Potisepp. Turg on avatud kõigile; Intervjuu Raimondas Useckasega

  20. Loodusesõber / Maria Martinez Ros ; küsis Marika Makarova

    Index Scriptorium Estoniae

    Martinez Ros, Maria

    2012-01-01

    Intervjuu Tallinnas ja Lilleorus tantsuteraapia kursusi andva mehhiklanna Maria Martinez Rosiga, kes on õppinud permakultuuri disaini, humanistliku psühholoogiat, tanatoloogiat, Feldenkraisi meetodit, tema vaadetest jätkusuutlikule elamise viisile

  1. Audentese koolid kolivad väärikatesse majadesse / Marika Karo

    Index Scriptorium Estoniae

    Karo, Marika

    2002-01-01

    Tartu linnavalitsus otsustas 9. mail 2002.a. müüa Tartus Puiestee tänaval asuva ajaloolise koolikompleksi ASile Audentes, kes kavatseb kinnistul olevatest kahest muinsuskaitse alla kuuluvast koolimajast, tööõpetuse majast, abihoonetest ja spordiplatsist välja arendada campus-tüüpi tänapäevase koolide kompleksi. Hooneid hakkavad kasutama Audentes Mainor Ülikooli Tartu filiaal ja alg- ja põhiharidust pakkuv Audentese Erakool. Koolihoonete kompleksi ajaloost

  2. Hamilton Park Care Facility, Balrothery, Balbriggan, Co. Dublin.

    LENUS (Irish Health Repository)

    Galvin, Miriam

    2018-01-27

    Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a debilitating terminal condition. Informal caregivers are key figures in ALS care provision. The physical, psychological and emotional impact of providing care in the home requires appropriate assistance and support. The objective of this analysis is to explore the needs of informal ALS caregivers across the caregiving course.

  3. Estimating the ROI on Implementation of RFID at the Ammunition Storage Warehouse and the 40th Supply Depot: KVA as a Methodology

    Science.gov (United States)

    2009-12-01

    Balanced Scorecard CAPM Capital Asset Pricing Model DIS Defense Information System DoD Department of...Measurement Tool (PMT) is the Balanced Scorecard (BSC) based on critical success factors and key performance indicators. The MND has referred to Jung’s...authors can replicate the methodology for multiple projects to generate a portfolio of projects. Similar to the Capital Asset Pricing Model ( CAPM ) or

  4. Needs of informal caregivers across the caregiving course in amyotrophic lateral sclerosis: a qualitative analysis.

    LENUS (Irish Health Repository)

    Galvin, Miriam

    2018-01-27

    Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a debilitating terminal condition. Informal caregivers are key figures in ALS care provision. The physical, psychological and emotional impact of providing care in the home requires appropriate assistance and support. The objective of this analysis is to explore the needs of informal ALS caregivers across the caregiving course.

  5. Structure and DNA-binding of meiosis-specific protein Hop2

    Science.gov (United States)

    Zhou, Donghua; Moktan, Hem; Pezza, Roberto

    2014-03-01

    Here we report structure elucidation of the DNA binding domain of homologous pairing protein 2 (Hop2), which is important to gene diversity when sperms and eggs are produced. Together with another protein Mnd1, Hop2 enhances the strand invasion activity of recombinase Dmc1 by over 30 times, facilitating proper synapsis of homologous chromosomes. However, the structural and biochemical bases for the function of Hop2 and Mnd1 have not been well understood. As a first step toward such understanding, we recently solved the structure for the N-terminus of Hop2 (1-84) using solution NMR. This fragment shows a typical winged-head conformation with recognized DNA binding activity. DNA interacting sites were then investigated by chemical shift perturbations in a titration experiment. Information of these sites was used to guide protein-DNA docking with MD simulation, revealing that helix 3 is stably lodged in the DNA major groove and that wing 1 (connecting strands 2 and 3) transiently comes in contact with the minor groove in nanosecond time scale. Mutagenesis analysis further confirmed the DNA binding sites in this fragment of the protein.

  6. Enno Toomsalu 30 aastat Chicago Eesti Maja president / Endel Sepp

    Index Scriptorium Estoniae

    Sepp, Endel

    2006-01-01

    1976. aastast Eesti Maja juhtinud Enno on kujundanud selle "väikeseks Eestiks", kus on korraldatud palju kultuuriüritusi. 19. märtsi koosolekul andis ta ameti nooremale, samas valiti ta Chicago Eesti Maja auliikmeks. Akadeemiliselt kuulub ta Korp! Frat. Estica´sse, teda on autasustatud korporatsiooni Kuldmärgiga teenete eest eestlusele ja Valgetähe 4. järgu ordeniga

  7. Ruhnu saarele hakkab lennutama Saksa firma / Mehis Tulk, Andres Sepp

    Index Scriptorium Estoniae

    Tulk, Mehis, 1967-

    2006-01-01

    Ilmunud ka: Meie Maa 9. nov lk. 1. Riigihankekonkursi Pärnu-Ruhnu-Kuressaare lennuliini teenindamiseks võitnud Saksa firmaga Luftverkehr Friesland Brunzema und Partner KG sõlmib Saare maavalitsus avaliku teenindamise lepingu neljaks aastaks. Kaart

  8. Ralf Tamm - unistaja tehismaastikul / Ralf Tamm ; interv. Aino Ingrid Sepp

    Index Scriptorium Estoniae

    Tamm, Ralf

    2008-01-01

    Eramuile spetsialiseerunud arhitekt Ralf Tamm sellest, miks ta eelistab projekteerida eramuid, eramust visiooni kujunemisest, betoonist, hea arhitektuuri loomise eeldustest, eesti arhitektuuri lähitulevikust, tuleviku töövahenditest, enda tööstiilist jm. Abikaasa disainer Angela Orgusaar Ralf Tammest. Eramu "Vana laev" tellija Tarmo Ojakääru kommentaar. 13 ill

  9. Omanikud lõpetavad skandaalse firma Kuressaare Golf tegevuse / Andres Sepp

    Index Scriptorium Estoniae

    Sepp, Andres, 1976-

    2004-01-01

    AS Kuressaare Golf likvideeritakse, sest Põduste jõe äärde kavandatud golfiväljaku ehitamise plaanid sumbusid, kuna firma aktsionäride vahel tekitas tüli rahakantimise kahtlus. Kommenteerib AS-i Kuressaare Golf juhatuse liige Meelis Põlda

  10. Uued raamatud

    Index Scriptorium Estoniae

    2008-01-01

    Fotoalbum "Väikeste majade Haapsalu" (Evald Okase Muuseum, 2008; toimetajad Üla Koppel ja Ingrid Ruudi, kujundaja Pärtel Eelma, fotod: Ly Lestberg, Katrin Rihm, Lembit Michelson, Liivia Leshkin, Piret Looveer, Erki Meister, Romer Laidsaar, Karli Luik, Maris Kerge, Üla Koppel). "Tallinna maja : hoonetüübi areng ja säästev uuendamine" (Tallinna Kultuuriväärtuste Amet, 2008; ajaloolise osa koostas Mark Sepp). Näituse kataloog "Keskkonnad, projektid, kontseptsioonid. Tallinna kooli arhitektid 1972-1985" (Eesti Arhitektuurimuuseum, 2008; koostajad Andres Kurg ja Mari Laanemets, kujundaja Indrek Sirkel, tekstid: A. Kurg, M. Laanemets, Juhani Pallasmaa, Georg Schöllhammer)

  11. Lipidomics in research on yeast membrane lipid homeostasis.

    Science.gov (United States)

    de Kroon, Anton I P M

    2017-08-01

    Mass spectrometry is increasingly used in research on membrane lipid homeostasis, both in analyses of the steady state lipidome at the level of molecular lipid species, and in pulse-chase approaches employing stable isotope-labeled lipid precursors addressing the dynamics of lipid metabolism. Here my experience with, and view on mass spectrometry-based lipid analysis is presented, with emphasis on aspects of quantification of membrane lipid composition of the yeast Saccharomyces cerevisiae. This article is part of a Special Issue entitled: BBALIP_Lipidomics Opinion Articles edited by Sepp Kohlwein. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. Milliseid erialaseid teadmisi ja oskusi olete kasutanud oma praeguses ametis? : vastavad infoteaduse eriala vilistlased / interv. Hela Ojasaar, Margot Mahlapuu

    Index Scriptorium Estoniae

    2005-01-01

    Vastavad: EV Presidendi Kantselei direktori asetäitja, üldosakonna juhataja Riina Roomet, Mahtra Talurahvamuuseumi direktor Tiia-Helle Schmitte, EBS-i raamatukogu juhataja Eda Pihu, Euroopa Liidu asjade komisjoni nõunik (Riigikogu) Külli Kask, Kultuuriministeeriumi raamatukogunõunik Meeli Veskus, Võrumaa Keskraamatukogu direktor Inga Kuljus, Lääne Maakonna Keskraamatukogu direktor Ilme Sepp, Riigiarhiivi direktor Marge Tiidus, kirjastuse Pilgrim juht Tiina Ristimets, Tallinna Keskraamatukogu direktor Kaie Holm, Eesti ENIC/NARIC Keskuse infospetsialist Liia Tüür, Eesti Rahvusraamatukogu direktor Tiiu Valm, Tartu Ülikooli Raamatukogu teenindusdirektor Mare-Nelli Ilus, Viljandi Kultuuriakadeemia raamatukogunduse ja infoteaduste osakonna juhataja Ilmar Vaaro

  13. 75 FR 12802 - Notice of Availability of Calendar Year 2011 Competitive Grant Funds

    Science.gov (United States)

    2010-03-17

    ... administering Federal funds provided for civil legal services to low-income people. LSC hereby announces the...-2, NNM-4 New York NY-9 North Dakota ND-3, MND, NND-3 Ohio OH-20, OH-18, OH-21, OH-23, MOH Oklahoma NOK-1 Pennsylvania PA-1, PA-24, MPA Puerto Rico PR-2 South Dakota SD-2, SD-4, MSD, NSD-1 Tennessee TN...

  14. A mixed methods evaluation of the maternal-newborn dashboard in Ontario: dashboard attributes, contextual factors, and facilitators and barriers to use: a study protocol.

    Science.gov (United States)

    Dunn, Sandra; Sprague, Ann E; Grimshaw, Jeremy M; Graham, Ian D; Taljaard, Monica; Fell, Deshayne; Peterson, Wendy E; Darling, Elizabeth; Harrold, JoAnn; Smith, Graeme N; Reszel, Jessica; Lanes, Andrea; Truskoski, Carolyn; Wilding, Jodi; Weiss, Deborah; Walker, Mark

    2016-05-04

    There are wide variations in maternal-newborn care practices and outcomes across Ontario. To help institutions and care providers learn about their own performance, the Better Outcomes Registry & Network (BORN) Ontario has implemented an audit and feedback system, the Maternal-Newborn Dashboard (MND), for all hospitals providing maternal-newborn care. The dashboard provides (1) near real-time feedback, with site-specific and peer comparison data about six key performance indicators; (2) a visual display of evidence-practice gaps related to the indicators; and (3) benchmarks to provide direction for practice change. This study aims to evaluate the effects of the dashboard, dashboard attributes, contextual factors, and facilitation/support needs that influence the use of this audit and feedback system to improve performance. The objectives of this study are to (1) evaluate the effect of implementing the dashboard across Ontario; (2) explore factors that potentially explain differences in the use of the MND among hospitals; (3) measure factors potentially associated with differential effectiveness of the MND; and (4) identify factors that predict differences in hospital performance. A mixed methods design includes (1) an interrupted time series analysis to evaluate the effect of the intervention on six indicators, (2) key informant interviews with a purposeful sample of directors/managers from up to 20 maternal-newborn care hospitals to explore factors that influence the use of the dashboard, (3) a provincial survey of obstetrical directors/managers from all maternal-newborn hospitals in the province to measure factors that influence the use of the dashboard, and (4) a multivariable generalized linear mixed effects regression analysis of the indicators at each hospital to quantitatively evaluate the change in practice following implementation of the dashboard and to identify factors most predictive of use. Study results will provide essential data to develop knowledge

  15. HIV associated neurocognitive disorders (HAND in Malawian adults and effect on adherence to combination anti-retroviral therapy: a cross sectional study.

    Directory of Open Access Journals (Sweden)

    Christine M Kelly

    Full Text Available Little is known about the prevalence and burden of HIV associated neurocognitive disorder (HAND among patients on combination antiretroviral therapy (cART in sub-Saharan Africa. We estimated the prevalence of HAND in adult Malawians on cART and investigated the relationship between HAND and adherence to cART.HIV positive adults in Blantyre, Malawi underwent a full medical history, neurocognitive test battery, depression score, Karnofsky Performance Score and adherence assessment. The Frascati criteria were used to diagnose HAND and the Global Deficit Score (GDS was also assessed. Blood was drawn for CD4 count and plasma nevirapine and efavirenz concentrations. HIV negative adults were recruited from the HIV testing clinic to provide normative scores for the neurocognitive battery.One hundred and six HIV positive patients, with median (range age 39 (18-71 years, 73% female and median (range CD4 count 323.5 (68-1039 cells/µl were studied. Symptomatic neurocognitive impairment was present in 15% (12% mild neurocognitive disorder [MND], 3% HIV associated dementia [HAD]. A further 55% fulfilled Frascati criteria for asymptomatic neurocognitive impairment (ANI; however factors other than neurocognitive impairment could have confounded this estimate. Neither the symptomatic (MND and HAD nor asymptomatic (ANI forms of HAND were associated with subtherapeutic nevirapine/efavirenz concentrations, adjusted odds ratio 1.44 (CI. 0.234, 8.798; p = 0.696 and aOR 0.577 (CI. 0.09, 3.605; p = 0.556 respectively. All patients with subtherapeutic nevirapine/efavirenz levels had a GDS of less than 0.6, consistent with normal neurocognition.Fifteen percent of adult Malawians on cART had a diagnosis of MND or HAD. Subtherapeutic drug concentrations were found exclusively in patients with normal neurocognitive function suggesting HAND did not affect cART adherence. Further study of HAND requires more robust locally derived normative neurocognitive values and

  16. Pedigree with frontotemporal lobar degeneration – motor neuron disease and Tar DNA binding protein-43 positive neuropathology: genetic linkage to chromosome 9

    Directory of Open Access Journals (Sweden)

    Loy Clement T

    2008-08-01

    Full Text Available Abstract Background Frontotemporal lobar degeneration (FTLD represents a clinically, pathologically and genetically heterogenous neurodegenerative disorder, often complicated by neurological signs such as motor neuron-related limb weakness, spasticity and paralysis, parkinsonism and gait disturbances. Linkage to chromosome 9p had been reported for pedigrees with the neurodegenerative disorder, frontotemporal lobar degeneration (FTLD and motor neuron disease (MND. The objective in this study is to identify the genetic locus in a multi-generational Australian family with FTLD-MND. Methods Clinical review and standard neuropathological analysis of brain sections from affected pedigree members. Genome-wide scan using microsatellite markers and single nucleotide polymorphism fine mapping. Examination of candidate genes by direct DNA sequencing. Results Neuropathological examination revealed cytoplasmic deposition of the TDP-43 protein in three affected individuals. Moreover, we identify a family member with clinical Alzheimer's disease, and FTLD-Ubiquitin neuropathology. Genetic linkage and haplotype analyses, defined a critical region between markers D9S169 and D9S1845 on chromosome 9p21. Screening of all candidate genes within this region did not reveal any novel genetic alterations that co-segregate with disease haplotype, suggesting that one individual carrying a meiotic recombination may represent a phenocopy. Re-analysis of linkage data using the new affection status revealed a maximal two-point LOD score of 3.24 and a multipoint LOD score of 3.41 at marker D9S1817. This provides the highest reported LOD scores from a single FTLD-MND pedigree. Conclusion Our reported increase in the minimal disease region should inform other researchers that the chromosome 9 locus may be more telomeric than predicted by published recombination boundaries. Moreover, the existence of a family member with clinical Alzheimer's disease, and who shares the disease

  17. Effects of regular physical activity on anthropometric and functional parameters in young and old women

    Directory of Open Access Journals (Sweden)

    Sebastião Gobbi

    2001-12-01

    Full Text Available The aim of the present study was to verify the strength levels and the arm cross-sectional-area (AMB of young and old women who practice physical activity regularly. Thirty female subjects were selected and distributed into two groups: young (G1 and old (G2. They were evaluated on maximal voluntary strength of elbow flexor muscle by 1RM (one-maximal repetition test (“biceps curl”, and the AMB, through the measures of arm circumference (CB and triceps skinfold (DCTr, which were then used with the equation proposed by Frisancho (1984: AMB (cm2 = [(CB - pDCTr2 / 4p] - 6.5, in both dominant (MD and non dominant (MND arms. Strength (kg and AMB (cm2 were analyzed by ANOVA to a significance level of 5%. The G2 strength level was significantly (p RESUMO O presente estudo teve como objetivo verificar os níveis de força e a área muscular do braço (AMB de mulheres jovens e idosas praticantes de atividade física regular. Para isso foram selecionados 30 sujeitos do sexo feminino, distribuídos em dois grupos: jovem (G1 e idoso (G2. Avaliou-se a força voluntária máxima dos músculos flexores do cotovelo pelo teste de 1RM (repetição máxima exercício “rosca unilateral” , e a AMB, através das medidas de circunferência de braço (CB e dobra cutânea tricipital (DCTr, que posteriormente foram incluídas na equação proposta por Frisancho (1984: AMB (cm = [(CB - pDCTr2 / 4p] - 6.5, em ambos os membros dominante (MD e não dominante (MND. Os valores de força (em kg e AMB (em cm2 foram analisados por ANOVA com nível de significância pré-estabelecido em 5%. O nível de força do G2 foi significativamente (p<0,01 menor que G1, tanto no MD quanto no MND. Em relação à AMB, o MND de G2 mostrou-se maior que G1, o que não ocorreu com o MD. A partir da análise dos resultados, concluiu-se que apesar do envelhecimento, a prática regular de atividade física pode prevenir a perda de massa muscular (MM. Contudo, a capacidade para gerar for

  18. The mortuary house at Lepna on southern Saaremaa / Marika Mägi

    Index Scriptorium Estoniae

    Mägi, Marika

    2004-01-01

    Kaevamistest Lepna Katkuauguks nimetatud matusekohal. Surnumaja ümbritsenud kultuurmaastikust, surnumaja jäänustest, matustest. Lepna surnumaja markeerib silmnähtavaid muudatusi Saaremaa matmiskombestikus 5. - 6. sajandil

  19. Intellekt ja selle areng imiku- ja väikelapseeas / Marika Veisson

    Index Scriptorium Estoniae

    Veisson, Marika, 1949-

    1998-01-01

    Kolm ajaloolist lähenemist intellekti uurimisele. Nancy Bayley poolt 1969.a. välja töötatud esimene põhjalikum väikelaste ja imikute intellekti uurimismetoodika - Bayley Imikute Arengu Skaala; psühhomeetriline lähenemine, J. Piaget kognitiivse arengu teooria

  20. Noor näitleja otsib rollides ennast / Marika Rajamäe

    Index Scriptorium Estoniae

    Rajamäe, Marika

    2006-01-01

    Tantsuõpetaja Helmi Tohvelmani nimelise liikuvaima näitleja preemia võttis vastu näitleja Tambet Tuisk, Järvamaa maakooli edukaima õpilase preemia aga Annely Tank, kes õpib Koigi Põhikooli 9. klassis

  1. Rahvakunst Marika ja Heinz Valgu kollektsioonist : Heie Treier soovitab / Heie Treier

    Index Scriptorium Estoniae

    Treier, Heie, 1963-

    2000-01-01

    12. märtsini Tarbekunstimuuseumis avatud näitusest, mille on kujundanud Heinz Valk. Soovitatakse külastada Kunstihoones Anu Juuraku näitust 'Tsoon 2', kus tegeldakse identiteedi probleemidega kõrgtehnoloogilisel tasandil.

  2. Tööandjate unistuste seaduse autorid olid tegelikult sotsid / Marika Tuus

    Index Scriptorium Estoniae

    Tuus, Marika, 1951-

    2008-01-01

    Uue töölepingu seaduse eelnõust. Ilmunud ka Virumaa Teataja 29. jaan. 2008, lk. 11 ; Hiiu Leht 29. jaan. 2008, lk. 2 ; Pärnu Postimees 29. jaan. 2008, lk. 15 ; Vali Uudised 30. jaan. 2008, lk. 2, pealkiri kujul: uus orjaaeg ; Meie Maa 29. jaan. 2008, lk. 2 ; Põhjarannik 30. jaan. 2008, lk. 2 ; Lääne Elu 29. jaan. 2008, lk. 2 ; Elva Postipoiss 2. veeb. 2008, lk. 4, pealkiri kujul: Kas uus orjaaeg? ; Kesknädal 6. veeb. 2008, lk. 2 ; Vooremaa 14. veeb. 2008, lk. 2

  3. Electron correlation effects in the half-metallic NiMnSb within a cluster-perturbation approach with ab-initio parameters

    Directory of Open Access Journals (Sweden)

    H. Allmaier

    2008-06-01

    Full Text Available  Using a combination of electronic-structure and many-body calculations, we investigate correlations effects in the halfmetallic ferromagnet NiMnSb. A realistic many-body Hamiltonian, containing only Mn-d orbitals shows the importance of non-quasiparticle states just above the Fermi level. Our results suggest that for a better description of low energy states around Fermi level, Ni-d orbitals should be explicitly included.

  4. Sialorrhoea: How to Manage a Frequent Complication of Motor Neuron Disease

    OpenAIRE

    Andrea Pellegrini; Christian Lunetta; Carlo Ferrarese; Lucio Tremolizzo

    2015-01-01

    Sialorrhoea, the unintentional loss of saliva through the mouth, is the frequent complication of neurological disorders affecting strength or coordination of oropharyngeal muscles, such as motor neuron disease/amyotrophic lateral sclerosis (MND/ALS) or Parkinson’s disease. Sialorrhoea might affect up to 42% of ALS patients, with almost half of them having poorly managed symptoms. Sialorrhoea can impair patients’ social life, while dermatological complications, such as skin rashes, may arise d...

  5. Finding Effective Responses Against Cyber Attacks for Divided Nations

    Science.gov (United States)

    2015-12-01

    Coordination Center LTE Long Term Evolution MAC Media Access Control MCRC Master Control and Reporting Center MEI Ministry of Electronics...satellites that aid Internet connections. Individual users can access the Internet via not only a wired connection up to 1 Gbps, but also by 4G LTE ...operate air-gapped intranets with security measures such as cryptographic modules that correspond to security levels. The MND does maintain the public

  6. Delineating hierarchy of selenotranscriptome expression and their response to selenium status in chicken central nervous system.

    Science.gov (United States)

    Jiang, Xiu-Qing; Cao, Chang-Yu; Li, Zhao-Yang; Li, Wei; Zhang, Cong; Lin, Jia; Li, Xue-Nan; Li, Jing-Long

    2017-04-01

    Selenium (Se) incorporated in selenoproteins as selenocysteine and supports various important cellular and organismal functions. We recently reported that chicken brain exhibited high priority for Se supply and retention under conditions of dietary Se deficiency and supernutrition Li et al. (2012) . However, the selenotranscriptome expressions and their response to Se status in chicken central nervous system (CNS) are unclear. To better understand the relationship of Se homeostasis and selenoproteins expression in chicken CNS, 1day-old HyLine White chickens were fed a low Se diet (Se-L, 0.028mg/g) supplemented with 4 levels of dietary Se (0 to 5.0mgSe/kg) as Na 2 SeO 3 for 8weeks. Then chickens were dissected for getting the CNS, which included cerebral cortex, cerebellum, thalamus, bulbus cinereus and marrow. The expressions of selenoproteome which have 24 selenoproteins were detected by the quantitative real-time PCR array. The concept of a selenoprotein hierarchy was developed and the hierarchy of different regions in chicken CNS was existence, especially cerebral cortex and bulbus cinereus. The expression of selenoproteins has a hierarch while changing Se content, and Selenoprotein T (Selt), Selenoprotein K (Selk), Selenoprotein W (Selw), Selenoprotein U (Selu), Glutathione peroxidase 3 (Gpx3), Glutathione peroxidase 4 (Gpx4), Selenoprotein P (Sepp1), Selenoprotein O (Selo), Selenoprotein 15 (Sel15), Selenoprotein N (Seln), Glutathione peroxidase 2 (Gpx2) and Selenoprotein P 2 (Sepp2) take more necessary function in the chicken CNS. Therefore, we hypothesize that hierarchy of regulated the transcriptions of selenoproteome makes an important role of CNS Se metabolism and transport in birds. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. Outcomes of physical therapy, speech pathology, and occupational therapy for people with motor neuron disease: a systematic review.

    Science.gov (United States)

    Morris, Meg E; Perry, Alison; Bilney, Belinda; Curran, Andrea; Dodd, Karen; Wittwer, Joanne E; Dalton, Gregory W

    2006-09-01

    This article describes a systematic review and critical evaluation of the international literature on the effects of physical therapy, speech pathology, and occupational therapy for people with motor neuron disease (PwMND). The results were interpreted using the framework of the International Classification of Functioning, Disability and Health. This enabled us to summarize therapy outcomes at the level of body structure and function, activity limitations, participation restrictions, and quality of life. Databases searched included MEDLINE, PUBMED, CINAHL, PSYCInfo, Data base of Abstracts of Reviews of Effectiveness (DARE), The Physiotherapy Evidence data base (PEDro), Evidence Based Medicine Reviews (EMBASE), the Cochrane database of systematic reviews, and the Cochrane Controlled Trials Register. Evidence was graded according to the Harbour and Miller classification. Most of the evidence was found to be at the level of "clinical opinion" rather than of controlled clinical trials. Several nonrandomized small group and "observational studies" provided low-level evidence to support physical therapy for improving muscle strength and pulmonary function. There was also some evidence to support the effectiveness of speech pathology interventions for dysarthria. The search identified a small number of studies on occupational therapy for PwMND, which were small, noncontrolled pre-post-designs or clinical reports.

  8. New trace element determinations in the fingernails of ALS patients

    Energy Technology Data Exchange (ETDEWEB)

    Van Dalsem, D.J.; Ehmann, W.D. [Univ. of Kentucky, Lexington, KY (United States); Robinson, L. [Oak Ridge National Laboratory, TN (United States)

    1996-12-31

    Amyotrophic lateral sclerosis (ALS) afflicts 2 of every 100,000 people in the United States each year. A well-known example of ALS today is Stephen Hawking. He is a theoretical physicist, the author of A Brief History of Time, and is virtually immobilized by ALS. Diseases that cause progressive paralysis because of motor neuron degeneration in the central nervous system are termed motor neuron disorders (MND). Amyotrophic lateral sclerosis is a common form of MND. Pain-free, progressive muscular weakness is the most common clinical symptom. There is chronic weakness with atrophy of the affected muscles by the time the disease is diagnosed. Atrophy eventually results in wheelchair confinement and then only bed without the ability to speak or swallow. Death often occurs as a result of respiratory problems. Unlike other neurodegenerative diseases, in ALS the patient`s bladder and bowel control, eye movement, and mental faculties are preserved. The question today is whether or not certain trace elements are involved in the etiology or pathogenesis of ALS. A collaborative study was undertaken by the University of Kentucky and Oak Ridge National Laboratory (ORNL) using neutron activation analysis (NAA) to study trace element concentrations in ALS patients fingernails to determine if there existed statistically significant imbalances.

  9. FTLD-TDP with motor neuron disease, visuospatial impairment and a progressive supranuclear palsy-like syndrome: broadening the clinical phenotype of TDP-43 proteinopathies. A report of three cases

    Directory of Open Access Journals (Sweden)

    Holmerová Iva

    2011-05-01

    Full Text Available Abstract Background Frontotemporal lobar degeneration with ubiquitin and TDP-43 positive neuronal inclusions represents a novel entity (FTLD-TDP that may be associated with motor neuron disease (FTLD-MND; involvement of extrapyramidal and other systems has also been reported. Case presentation We present three cases with similar clinical symptoms, including Parkinsonism, supranuclear gaze palsy, visuospatial impairment and a behavioral variant of frontotemporal dementia, associated with either clinically possible or definite MND. Neuropathological examination revealed hallmarks of FTLD-TDP with major involvement of subcortical and, in particular, mesencephalic structures. These cases differed in onset and progression of clinical manifestations as well as distribution of histopathological changes in the brain and spinal cord. Two cases were sporadic, whereas the third case had a pathological variation in the progranulin gene 102 delC. Conclusions Association of a "progressive supranuclear palsy-like" syndrome with marked visuospatial impairment, motor neuron disease and early behavioral disturbances may represent a clinically distinct phenotype of FTLD-TDP. Our observations further support the concept that TDP-43 proteinopathies represent a spectrum of disorders, where preferential localization of pathogenetic inclusions and neuronal cell loss defines clinical phenotypes ranging from frontotemporal dementia with or without motor neuron disease, to corticobasal syndrome and to a progressive supranuclear palsy-like syndrome.

  10. Adult-onset Alexander disease, associated with a mutation in an alternative GFAP transcript, may be phenotypically modulated by a non-neutral HDAC6 variant.

    Science.gov (United States)

    Melchionda, Laura; Fang, Mingyan; Wang, Hairong; Fugnanesi, Valeria; Morbin, Michela; Liu, Xuanzhu; Li, Wenyan; Ceccherini, Isabella; Farina, Laura; Savoiardo, Mario; D'Adamo, Pio; Zhang, Jianguo; Costa, Alfredo; Ravaglia, Sabrina; Ghezzi, Daniele; Zeviani, Massimo

    2013-05-01

    We studied a family including two half-siblings, sharing the same mother, affected by slowly progressive, adult-onset neurological syndromes. In spite of the diversity of the clinical features, characterized by a mild movement disorder with cognitive impairment in the elder patient, and severe motor-neuron disease (MND) in her half-brother, the brain Magnetic Resonance Imaging (MRI) features were compatible with adult-onset Alexander's disease (AOAD), suggesting different expression of the same, genetically determined, condition. Since mutations in the alpha isoform of glial fibrillary acidic protein, GFAP-α, the only cause so far known of AOAD, were excluded, we applied exome Next Generation Sequencing (NGS) to identify gene variants, which were then functionally validated by molecular characterization of recombinant and patient-derived cells. Exome-NGS revealed a mutation in a previously neglected GFAP isoform, GFAP-ϵ, which disrupts the GFAP-associated filamentous cytoskeletal meshwork of astrocytoma cells. To shed light on the different clinical features in the two patients, we sought for variants in other genes. The male patient had a mutation, absent in his half-sister, in X-linked histone deacetylase 6, a candidate MND susceptibility gene. Exome-NGS is an unbiased approach that not only helps identify new disease genes, but may also contribute to elucidate phenotypic expression.

  11. Predictors of activity and participation across neurodegenerative conditions: a comparison of people with motor neurone disease, multiple sclerosis and Parkinson's disease.

    Science.gov (United States)

    Morley, David; Dummett, Sarah; Kelly, Laura; Fitzpatrick, Ray; Jenkinson, Crispin

    2018-02-17

    Comparisons between neurological conditions have the potential to inform service providers by identifying particular areas of difficulty experienced by affected individuals. This study aimed to identify predictors of activity and participation in people with motor neurone disease (MND), people with multiple sclerosis (MS) and people with Parkinson's Disease (PD). The Oxford Participation and Activities Questionnaire (Ox-PAQ) and Medical Outcomes Study 36-Item Short Form Survey (MOS SF-36) were administered by postal survey to 386 people with a confirmed diagnosis of MND, MS or PD. Data analyses focused on stepwise regression analyses in order to identify predictors of activity and participation in the three conditions assessed. Three hundred and thirty four participants completed the survey, a response rate of 86.5%. Regression analyses identified multiple predictors of activity and participation dependent on Ox-PAQ domain and disease group, the most prominent being social and physical functioning as measured by the MOS SF-36. Results indicate that the physical and social consequences of neurological illness are of greatest relevance to people experiencing the conditions assessed. Whilst the largely inevitable physical implications of disease take hold, emphasis should be placed on the avoidance of social withdrawal and isolation, and the maintenance of social engagement should become a significant priority.

  12. Systematic review of non-invasive positive pressure ventilation for chronic respiratory failure.

    Science.gov (United States)

    Hannan, Liam M; Dominelli, Giulio S; Chen, Yi-Wen; Darlene Reid, W; Road, Jeremy

    2014-02-01

    This systematic review examined the effect of non-invasive positive pressure ventilation (NIPPV) on patient reported outcomes (PROs) and survival for individuals with or at risk of chronic respiratory failure (CRF). Randomised controlled trials (RCTs) and prospective non-randomised studies in those treated with NIPPV for CRF were identified from electronic databases, reference lists and grey literature. Diagnostic groups included in the review were amyotrophic lateral sclerosis/motor neuron disease (ALS/MND), Duchenne muscular dystrophy (DMD), restrictive thoracic disease (RTD) and obesity hypoventilation syndrome (OHS). Eighteen studies were included and overall study quality was weak. Those with ALS/MND had improved somnolence and fatigue as well as prolonged survival with NIPPV. For OHS, improvements in somnolence and fatigue, dyspnoea and sleep quality were demonstrated, while for RTD, measures of dyspnoea, sleep quality, physical function and health, mental and emotional health and social function improved. There was insufficient evidence to form conclusions regarding the effect of NIPPV for those with DMD. This review has demonstrated that NIPPV influences PROs differently depending on the underlying cause of CRF. These findings may provide assistance to patients and clinicians to determine the relative costs and benefits of NIPPV therapy and also highlight areas in need of further research. Copyright © 2013 Elsevier Ltd. All rights reserved.

  13. iPSC-Based Models to Unravel Key Pathogenetic Processes Underlying Motor Neuron Disease Development

    Directory of Open Access Journals (Sweden)

    Irene Faravelli

    2014-10-01

    Full Text Available Motor neuron diseases (MNDs are neuromuscular disorders affecting rather exclusively upper motor neurons (UMNs and/or lower motor neurons (LMNs. The clinical phenotype is characterized by muscular weakness and atrophy leading to paralysis and almost invariably death due to respiratory failure. Adult MNDs include sporadic and familial amyotrophic lateral sclerosis (sALS-fALS, while the most common infantile MND is represented by spinal muscular atrophy (SMA. No effective treatment is ccurrently available for MNDs, as for the vast majority of neurodegenerative disorders, and cures are limited to supportive care and symptom relief. The lack of a deep understanding of MND pathogenesis accounts for the difficulties in finding a cure, together with the scarcity of reliable in vitro models. Recent progresses in stem cell field, in particular in the generation of induced Pluripotent Stem Cells (iPSCs has made possible for the first time obtaining substantial amounts of human cells to recapitulate in vitro some of the key pathogenetic processes underlying MNDs. In the present review, recently published studies involving the use of iPSCs to unravel aspects of ALS and SMA pathogenesis are discussed with an overview of their implications in the process of finding a cure for these still orphan disorders.

  14. Chemical Genetic Screens for TDP-43 Modifiers and ALS Drug Discovery

    Science.gov (United States)

    2015-03-01

    Champagne , and Pierre Drapeau. 25th international symposium on ALS/MND (5-7 December 2014) Patten SA, Vaccaro A, Drapeau P, Kabashi E, Parker JA...transgenic mice produced with TDP- 43 genomic fragments. Brain 134, 2610-2626 (2011). 6 Kabashi, E., Champagne , N., Brustein, E. & Drapeau, P. In the...swim of things: recent insights to neurogenetic disorders from zebrafish. Trends Genet 26, 373-381 (2010). 7 Kabashi, E., Brustein, E., Champagne , N

  15. Correlations of volcanic ash texture with explosion earthquakes from vulcanian eruptions at Sakurajima volcano, Japan

    Science.gov (United States)

    Miwa, T.; Toramaru, A.; Iguchi, M.

    2009-07-01

    We compare the texture of volcanic ash with the maximum amplitude of explosion earthquakes ( Aeq) for vulcanian eruptions from Sakurajima volcano. We analyze the volcanic ash emitted by 17 vulcanian eruptions from 1974 to 1987. Using a stereoscopic microscope, we classify the glassy particles into smooth surface particles (S-type particles) and non-smooth surface particles (NS-type particles) according to their surface conditions—gloss or non-gloss appearance—as an indicator of the freshness of the particles. S-type particles are further classified into V-type particles (those including vesicles) and NV-type particles (those without vesicles) by means of examinations under a polarized microscopic of polished thin sections. Cross-correlated examinations against seismological data show that: 1) the number fraction of S-type particles (S-fraction) has a positive correlation with Aeq, 2) the number ratio of NV-type particles to V-type particles (the N/V number ratio) has a positive correlation with Aeq, and 3) for explosions accompanied with BL-type earthquake swarms, the N/V number ratio has a negative correlation with the duration of the BL-Swarms. BL-Swarms refer to the phenomenon of numerous BL-type earthquakes occurring within a few days, prior to an increase in explosive activity [Kamo, K., 1978. Some phenomena before the summit crater eruptions at Sakura-zima volcano. Bull. Volcanol. Soc. Japan., 23, 53-64]. The positive correlation between the N/V number ratio and Aeq could indicate that a large amount of separated gas from fresh magma results in a large Aeq. Plagioclase microlite textual analysis of NV-type particles from five explosive events without BL-Swarms shows that the plagioclase microlite number density (MND) and the L/ W (length/width) ratio have a positive correlation with Aeq. A comparison between textural data (MND, L/ W ratio, crystallinity) and the result of a decompression-induced crystallization experiment [Couch, S., Sparks, R

  16. Raginal rannavormi / kommenteerinud Reet Puks, Merily Lehis, Helle Nurmsalu, Galina Sepp

    Index Scriptorium Estoniae

    2010-01-01

    Ilusalongides pakutavatest salendavatest kehahooldusprotseduuridest aparaatidega - LPG edermoloogiline massaaž, Universal Contour Wrap, ULTRATONE intensiivne tselluliidiravi ja mittekirurgiline facelift, Shockmaster AWT meetod (akustilise laine ravi)

  17. Medida da velocidade de condução nervosa motora em praticantes de três diferentes modalidades esportivas

    Directory of Open Access Journals (Sweden)

    Luís Paulo Nogueira Cabral Borges

    2013-10-01

    Full Text Available INTRODUÇÃO: Estudos da condução nervosa têm sido focados para o público em geral, porém não para atletas, havendo carência de informações sobre medidas da velocidade de condução nervosa motora (VCNM em indivíduos treinados, especialmente quando diferentes esportes são comparados. OBJETIVO: Medir a VCNM do nervo mediano e fibular comum, em três grupos de modalidades esportivas. Métodos: Foram analisados: um grupo de meio-fundistas (Gmf, n = 6, um grupo de velocistas (Gvel, n = 4 e um grupo de jogadores de handebol (Ghan, n = 5 e comparados com um grupo controle (Gcon, n = 9. Cada voluntário foi submetido a um único exame, no qual foram obtidos os dados para calcular a VCNM dos membros inferiores do Gmf e do Gvel, dos membros superiores do Ghan, e membros superiores e inferiores do Gcon. Os dados da pesquisa apresentaram distribuição normal e variâncias homogêneas, assim, utilizamos o teste t de Student para amostras independentes na comparação das médias da VCNM dos grupos de atletas com as do Gcon e as do Gvel com as do Gmf (comparações intergrupo. O teste t pareado foi usado para comparar as médias da VCNM entre membro dominante (Md e membro não dominante (Mnd (comparações intragrupo. RESULTADOS: Na análise intergrupo foram encontradas diferenças significativas nas comparações entre o Gvel e o Gcon e entre o Gmf e o Gcon (diferença apenas nas comparações entre os Md's. Por outro lado, a análise intragrupo, exibiu diferença significativa apenas nas comparações entre Md e Mnd do Ghan. CONCLUSÃO: O estudo sugere que a VCNM é beneficiada pelo esforço físico, principalmente em esportes com uso predominante dos membros inferiores, e que a maior utilização de um membro superior sobre outro pode levar a diferença significativa nos valores da VCNM do Md e Mnd.

  18. Multidecadal trends in the nesting phenology of Pacific and Atlantic leatherback turtles are associated with population demography

    OpenAIRE

    Robinson, Nathan J.; Valentine, Sara E.; Santidrián Tomillo, Pilar; Saba, Vincent S.; Spotila, James R.; Paladino, Frank V.

    2013-01-01

    Knowledge of the mechanisms influencing phenology can provide insights into the adaptability of species to climate change. Here, we investigated the factors influencing multidecadal trends in the nesting phenology of the leatherback turtle Dermochelys coriacea at Playa Grande, Costa Rica, in the eastern Pacific Ocean and at Sandy Point, US Virgin Islands, in the western Atlantic Ocean. Between 1993 and 2013, the median nesting date (MND) at Playa Grande occurred later, at a rate of ~0.3 d yr-...

  19. United States Air Force Statistical Digest, Fiscal Year 1976 and Transition Quarter (TQ). 31st Edition

    Science.gov (United States)

    1977-04-30

    JMM JMP JPB JlO J11 KBD KBK KCF KCG KCK KCM KCQ KDB KDC KDF KDM KDQ KDR KEA KEB KEC KFB KFC KFS KFU KGL KGM KGN KGX KHD KND LBM LED MBK ITEM DESCRIPTION...KDF KD1’! KDQ KDR KEA KEB KEC KFC KFS KFU KGL KGM KGN KGX KHO KND LBI’ LED MBK MBN 1’!CE MCF MOB MEA MEB MEC MGX MND RBC RED SFJ SFK YFB 474 475 490

  20. Selenium deficiency occurs in some patients with moderate-to-severe cirrhosis and can be corrected by administration of selenate but not selenomethionine: a randomized controlled trial123

    Science.gov (United States)

    Burk, Raymond F; Hill, Kristina E; Motley, Amy K; Byrne, Daniel W; Norsworthy, Brooke K

    2015-01-01

    Background: Selenomethionine, which is the principal dietary form of selenium, is metabolized by the liver to selenide, which is the form of the element required for the synthesis of selenoproteins. The liver synthesizes selenium-rich selenoprotein P (SEPP1) and secretes it into the plasma to supply extrahepatic tissues with selenium. Objectives: We conducted a randomized controlled trial to determine whether cirrhosis is associated with functional selenium deficiency (the lack of selenium for the process of selenoprotein synthesis even though selenium intake is not limited) and, if it is, whether the deficiency is associated with impairment of selenomethionine metabolism. Design: Patients with Child-Pugh (C-P) classes A, B, and C (mild, moderate, and severe, respectively) cirrhosis were supplemented with a placebo or supranutritional amounts of selenium as selenate (200 or 400 μg/d) or as selenomethionine (200 μg/d) for 4 wk. Plasma SEPP1 concentration and glutathione peroxidase (GPX) activity, the latter due largely to the selenoprotein GPX3 secreted by the kidneys, were measured before and after supplementation. Results: GPX activity was increased more by both doses of selenate than by the placebo in C-P class B patients. The activity was not increased more by selenomethionine supplementation than by the placebo in C-P class B patients. Plasma selenium was increased more by 400 μg Se as selenate than by the placebo in C-P class C patients. Within the groups who responded to selenate, there was a considerable variation in responses. Conclusion: These results indicate that severe cirrhosis causes mild functional selenium deficiency in some patients that is associated with impaired metabolism of selenomethionine. This trial was registered at clinicaltrials.gov as NCT00271245. PMID:26468123

  1. Excavations on the Coasts of Prehistoric and Medieval Saaremaa / Marika Mägi

    Index Scriptorium Estoniae

    Mägi, Marika, 1968-

    2006-01-01

    Viltina võimaliku sadamakoha kaevamistest. Leiti järjekordne 11. sajandi leiukompleks, seekord tüüpilistest Saaremaa naise ehetest. Pällamõisas on inimtegevus saanud alguse ilmselt I aastatuhande keskel, mil see paiknes otse mererannal. Inimtegevus Pällamõisas lakkas ilmselt keskaja alguses. 16. sajandi algul rajati sellele kohale hoonekompleks, mis juba 17. sajandil hüjati. Proovikaevamistest Tammese asulakohal

  2. Inimese papilloomiviiruse vastane vaktsiin imet ei tee, aga kaitseb siiski / Marika Kusnets

    Index Scriptorium Estoniae

    Kusnets, Marika

    2006-01-01

    5. oktoobril korraldas ravimifirma Merck Sharp & Dohme koostöös erialaarstide, Eesti Vähiliidu ja Quattromediga ajakirjanikele ümarlaua, kus räägiti emakakaelavähi põhjustest ja ravist, HPV tüüpidest, nakatumis- ja kaitsemehhanismidest ning uuest Eesti turule jõudvast vaktsiinist

  3. Rain Jõgi : Kehtivat trendi on keeruline murda / Rain Jõgi ; interv. Marika Kusnets

    Index Scriptorium Estoniae

    Jõgi, Rain

    2006-01-01

    TÜ kliinikumi kopsukliiniku juhataja kommenteerib European Community Respiratory Health Survey rahvusvahelist uuringut ja eestlaste suitsetamisharjumusi hingamisteede haiguste riskiteguritena üldisemas plaanis

  4. Parim proosalugeja köitis küpsusega / Marika Rajamäe

    Index Scriptorium Estoniae

    Rajamäe, Marika, 1952-

    2008-01-01

    Toimus viies üle-eestiline proosalugemine "Hansenist Tammsaareni". Mõtteid võistulugemise kohta avaldavad konkursi algataja Enda Trubok, Järva maavalitsuse haridus- ja kultuuriosakonna peainspektor Anne Viljat, Eesti emakeeleõpetajate seltsi esimees Piret Järvela, žürii esimees Iivi Lepik, konkursil võistelnud Merilin Kulpsoo. Peavõidu sai Sabine Liias, V-VII klasside arvestuses läks I koht Sabine Liiasele, II koht Kristian Käreskile, III koht Kristiina Orasele. VIII-IX arvestuses läks I koht Katriin Altementile, II koht Indrek Jõele, III koht Linda Randojale. X-XII klasside arvestuses võitis Kaire Olesk, II koha saii Sten-Robert Pullerits ning III koha Katrin Ojalill

  5. Host feeding pattern of Japanese encephalitis virus vector mosquitoes (Diptera: Culicidae) from Kuttanadu, Kerala, India.

    Science.gov (United States)

    Philip Samuel, P; Arunachalam, N; Hiriyan, J; Tyagi, B K

    2008-09-01

    Identification of blood meals of vector mosquitoes is an important tool in the epidemiological investigations of vector-borne diseases. The blood meals of three mosquito species involved in the transmission of Japanese encephalitis virus (JEV) from the Kuttanadu area, Kerala, were determined using the agarose gel diffusion technique. A total of 4959 blood smears belonging to Culex (Culex) tritaeniorhynchus Giles (3273), Cx. (Culex) gelidus Theobald (64), Mansonia (Mnd.) indiana Edwards (735) ,and Ma. (Mnd.) uniformis (Theobald) (887) were tested. Cx. tritaeniorhynchus had predominantly fed on bovids (46.4%), and a good proportion (29%) had fed on more than one host. Cx. tritaeniorhynchus was highly zoophagic, and human feeding accounted for only 1.5% of those individuals successfully tested. Cx. gelidus showed bovid feeding at 36% and pig feeding at 12.5%. The test results showed 42.3% Ma. indiana and 12.2% Ma. uniformis had fed on humans. Multiple feeding was observed in Ma. indiana and Ma. uniformis, and most of the double feedings were from bovids and ovids (7.9 and 20.1%, respectively). Pig feeding accounted for 4.8% of the feedings by Cx. tritaeniorhynchus, 5.3% of Ma. indiana, and 6.4% of Ma. uniformis. This study is significant because of the role played by these mosquitoes in the transmission of JEV in the Kuttanadu area of Kerala, India.

  6. Survival in the pre-senile dementia frontotemporal lobar degeneration with TDP-43 proteinopathy: effects of genetic, demographic and neuropathological variables

    Directory of Open Access Journals (Sweden)

    Richard A. Armstrong

    2016-06-01

    Full Text Available Factors associated with survival were studied in 84 neuropathologically documented cases of the pre-senile dementia frontotemporal dementia lobar degeneration (FTLD with transactive response (TAR DNA-binding protein of 43 kDa (TDP-43 proteinopathy (FTLD-TDP. Kaplan-Meier survival analysis estimated mean survival as 7.9 years (range: 1-19 years, SD = 4.64. Familial and sporadic cases exhibited similar survival, including progranulin (GRN gene mutation cases. No significant differences in survival were associated with sex, disease onset, Braak disease stage, or disease subtype, but higher survival was associated with lower post-mortem brain weight. Survival was significantly reduced in cases with associated motor neuron disease (FTLD-MND but increased with Alzheimer’s disease (AD or hippocampal sclerosis (HS co-morbidity. Cox regression analysis suggested that reduced survival was associated with increased densities of neuronal cytoplasmic inclusions (NCI while increased survival was associated with greater densities of enlarged neurons (EN in the frontal and temporal lobes. The data suggest that: (1 survival in FTLD-TDP is more prolonged than typical in pre-senile dementia but shorter than some clinical subtypes such as the semantic variant of primary progressive aphasia (svPPA, (2 MND co-morbidity predicts poor survival, and (3 NCI may develop early and EN later in the disease. The data have implications for both neuropathological characterization and subtyping of FTLD-TDP.

  7. A mutation in human VAP-B--MSP domain, present in ALS patients, affects the interaction with other cellular proteins.

    Science.gov (United States)

    Mitne-Neto, M; Ramos, C R R; Pimenta, D C; Luz, J S; Nishimura, A L; Gonzales, F A; Oliveira, C C; Zatz, M

    2007-09-01

    Amyotrophic Lateral Sclerosis (ALS) is the most common adult-onset Motor Neuron Disease (MND), characterized by motor neurons death in the cortex, brainstem and spinal cord. Ten loci linked to Familial ALS have been mapped. ALS8 is caused by a substitution of a proline by a serine in the Vesicle-Associated Membrane Protein-Associated protein-B/C (VAP-B/C). VAP-B belongs to a highly conserved family of proteins implicated in Endoplasmic Reticulum-Golgi and intra-Golgi transport and microtubules stabilization. Previous studies demonstrated that the P56S mutation disrupts the subcellular localization of VAP-B and that this position would be essential for Unfolded Protein Response (UPR) induced by VAP-B. In the present work we expressed and purified recombinant wild-type and P56S mutant VAP-B-MSP domain for the analysis of its interactions with other cellular proteins. Our findings suggest that the P56S mutation may lead to a less stable interaction of this endoplasmic reticulum protein with at least two other proteins: tubulin and GAPDH. These two proteins have been previously related to other forms of neurodegenerative diseases and are potential key points to understand ALS8 pathogenesis and other forms of MND. Understanding the role of these protein interactions may help the treatment of this devastating disease in the future.

  8. The management of amyotrophic lateral sclerosis.

    LENUS (Irish Health Repository)

    Phukan, Julie

    2009-02-01

    The terms amyotrophic lateral sclerosis (ALS) or motor neuron disease (MND) refer to a condition characterized by motor system degeneration with relative preservation of other pathways. Although there have been advances in symptomatic treatment, ALS remains an incurable condition. Advances in ALS management prolong survival but simultaneously raise challenging ethical dilemmas for physicians, patients and their families. Here, we review current practice in the management of ALS including pharmacological treatment, nutritional management, respiratory care, and evolving strategies in the management of cognitive impairment.

  9. Kasvatusteaduslike tööde konkursi tulemused / Ulve Kala

    Index Scriptorium Estoniae

    Kala, Ulve, 1947-

    2002-01-01

    Eesti keeles publitseeritud teadustöö preemia anti Aleksander Elangole, Inger Kraavile ja Kristi Kõivule, diplom Ühiskondlikule Pedagoogika Uurimise Instituudile, Viivi Ekstale, Inger Kraavile, Inge Undile, Viivi Maansole. Võõrkeeles publitseeritud teadustöö preemia monograafiale "Integration als Problem in der Erziehungswissenschaft" (koostaja Airi Liimets, autorid Airi Liimets, Saila Anttonen, Gunnar Bergendal, Gerd-Bodo Reinert von Carlsburg, Helmut Wehr, Tiiu Kuurme, Pauli Siljander, Jüri Kruusvall, Sirje Priimägi, Ene-Silvia Sarv, Kristi Kõiv, Meri-Liis Laherand, Jaan Mikk, Hannele Niemi, Marika Veisson, Irina Würscher, Susanne Jena, Tiina Aunin, Reet Liimets, Heli Mattisen, Aivo Saar, Maie Vikat), diplom Aino Saarele ja Katrin Niglasele. Didaktilis-rakenduslike tööde preemia Eda Heinlale, Estelle Laanele ja Kalle Laanele, Tiiu Kadajasele. Populaarteadusliku töö preemia Maie Tuulikule, diplom Kristi Kõivule. H. Liimetsa nim magistritööde preemia Rain Mikserile, Margus Pedastele, Ülle Rannutile, Inger Kraavile, Tago Sarapuule, Martin Ehalale

  10. Dislocation structures in 16MND5 pressure vessel steel strained in uniaxial tension

    Czech Academy of Sciences Publication Activity Database

    Obrtlík, Karel; Robertson, Ch.; Marini, B.

    2005-01-01

    Roč. 342, - (2005), s. 35-41 ISSN 0022-3115 R&D Projects: GA AV ČR(CZ) 1QS200410502 Institutional research plan: CEZ:AV0Z20410507 Keywords : bainitic steels * dislocation structure * low temperature deformation Subject RIV: JG - Metallurgy Impact factor: 1.414, year: 2005

  11. Multivokselska magnetno-rezonantna spektroskopija mozga kod HIV+ pacijenata

    OpenAIRE

    Boban, Jasmina

    2016-01-01

    UVOD: Neurokognitivni poremećaj udružen sa HIVinfekcijom (HIV associated neurocognitive disorder- HAND) javlja se u oko polovine pacijenata sa HIV-om. HAND obuhvata spektar neuroloških poremećaja koji variraju od asimptomatskog neurokognitivnog poremećaja(ANI), preko blagog kognitivnog oštećenja, koje se naziva blagi kognitivni poremećaj (MND) do demencije udružene sa HIV-om (HAD). U evaluaciji i dijagnostici ovog poremećaja koriste se razne laboratorijske, kliničke i metode imi...

  12. Akrobaatikaõpetaja lõi Draculateemalise tsirkuseetenduse / Alissa Šnaider ; intervjueerinud Andreas Sepp

    Index Scriptorium Estoniae

    Šnaider, Alissa, 1985-

    2011-01-01

    Kadriorus 5.-13. augustini kestva rahvusvahelise uue tsirkuse festivali "Tsirkusepuu" raames esietendub 12. augustil stuudio OMAtsirkuse "Dr. Acula". Intervjuu tsirkuseetenduse lavastanud akrobaatikaõpetaja ja koreograafi Alissa Šnaideriga

  13. "Soft" factors of economic development : human capital and institutsions / Jüri Sepp

    Index Scriptorium Estoniae

    Sepp, Jüri

    2006-01-01

    Töös on analüüsitud võimalusi empiiriliselt eristada riikide tegelikult saavutatud ja potentsiaalset majandusarengu taset. Tugineti mõlemale majandusarengu tugiteooriale - tootmisfunktsioonist lähtuvale kasvuteooriale ja institutsionaalsele arengukontseptsioonile. Eesti konvergentsivõimalusest arenenud riikidega

  14. Roberto Dapit, La Slavia friulana - Beneška Slovenija. Lingue e culture: Resia, Torre, Natisone - Jezik in kultura: Rezija, Ter, Nadiža. Bibliografia ragionata - Kritična biblio­grafija, Circolo Zadroga "Lipa", San Pietro al Natisone - Špeter 1995, 138 p.

    Directory of Open Access Journals (Sweden)

    Mitja Skubic

    1995-12-01

    Full Text Available E' possibile che al linguista non slavista il titolo non dica gran che. Eppure, per merito anche del linguista polacco Ian Baudouin de Courtenay, il dialetto sloveno di Resia, del Torre e del Natisone, queste parlate slovene sono fra le più studiate, anche dai linguisti stranieri: De Courtenay, poi, più recentemente Gian Battista Pellegrini, Giu­ seppe Francescato, Giovanni Frau, Antonio Maria Raffo da parte italiana e friulana; per la parte slovena possiamo ricordare Karel Strekelj, Fran Ramovs, Tine Logar, Pavle Merkù, Neva Godini, Liliana Spinozzi-Monai, Rado Lencek. E' doveroso, poi, citare l'americano Eric Hamp e l'olandese Han Steenwijk. Un posto a parte spetta a Milka Maticetov perché congiunge gli interessi linguistici con quelli etnologici.

  15. [The study of chronic partial denervation and quality of life in patients with motor neuron disease treated with semax].

    Science.gov (United States)

    Serdiuk, A V; Levitskiĭ, G N; Miasoedov, N F; Skvortsova, V I

    2007-01-01

    The study of chronic partial denervation (CPD) and quality of life was carried out in 27 patients with definite, probable and possible diagnosis of motor neuron disease (MND) treated with semax (1% solution). The needle electromyography (EMG) was performed thrice with short-term 2 month interval (60 days before enrollment and on day 1 and day 48 of the study) in three muscles on bulbar, cervical and lumbosacral levels on the less affected side. According to Revised El-Escorial Criteria (1998) the needle EMG for diagnostic purposes was also performed in two muscles on the cervical and lumbosacral levels on the more affected side along with stimulation electroneuronmyography of motor and sensory fibers of the peripheral nerves of neck, upper and lower extremities. The open-label clinical trial of Semax (1% solution) was conducted in sequential groups of patients. The drug was administered intranasally in two 10-day-long courses with 2-weeks break in daily dose of 12 mg. Sixty days before enrollment, and on days 1, 10, 24, 34 and 48, patients were assessed by the Norris ALS, the ALS Functioning Rating Scale and the ALSAQ-40 quality of life in the ALS scale. It was shown that CPD on the early as well as on the late stages was characterized by forward-backward, but not unidirectional course, that did not allow to recommend the follow-up needle EMG with short-term interval for evaluation of drug efficacy monitoring. Early CPD stages were characterized by forward-backwards fluctuations reflecting the compensatory reinnervation process (a phenomenon of exchange of muscle fibers, more rational in view of reinnervation, between adjacent motor units) whereas on the late CPD stages these forward-backwards CPD fluctuations reflected the processes of progressive deterioration of muscle fibers and secondary demyelination of large motor axons. Semax (1% solution) does not influence either the course of CPD or the dynamics of clinical estimates, in particular the terms of ensuing

  16. A micromechanical interpretation of the temperature dependence of Beremin model parameters for French RPV steel

    International Nuclear Information System (INIS)

    Mathieu, Jean-Philippe; Inal, Karim; Berveiller, Sophie; Diard, Olivier

    2010-01-01

    Local approach to brittle fracture for low-alloyed steels is discussed in this paper. A bibliographical introduction intends to highlight general trends and consensual points of the topic and evokes debatable aspects. French RPV steel 16MND5 (equ. ASTM A508 Cl.3), is then used as a model material to study the influence of temperature on brittle fracture. A micromechanical modelling of brittle fracture at the elementary volume scale already used in previous work is then recalled. It involves a multiscale modelling of microstructural plasticity which has been tuned on experimental inter-phase and inter-granular stresses heterogeneities measurements. Fracture probability of the elementary volume can then be computed using a randomly attributed defect size distribution based on realistic carbides repartition. This defect distribution is then deterministically correlated to stress heterogeneities simulated within the microstructure using a weakest-link hypothesis on the elementary volume, which results in a deterministic stress to fracture. Repeating the process allows to compute Weibull parameters on the elementary volume. This tool is then used to investigate the physical mechanisms that could explain the already experimentally observed temperature dependence of Beremin's parameter for 16MND5 steel. It is showed that, assuming that the hypothesis made in this work about cleavage micro-mechanisms are correct, effective equivalent surface energy (i.e. surface energy plus plastically dissipated energy when blunting the crack tip) for propagating a crack has to be temperature dependent to explain Beremin's parameters temperature evolution.

  17. Nd(III) and Dy(III) coordination compounds based on 1H-tetrazolate-5-acetic acid ligands: Synthesis, crystal structures and catalytic properties

    Energy Technology Data Exchange (ETDEWEB)

    Li Qiaoyun; Chen Dianyu; He Minghua [Jiangsu Laboratory of Advanced Functional Materials, Department of Chemistry and Materials Engineering, Changshu Institute of Technology, Changshu 215500, Jiangsu (China); Yang Gaowen, E-mail: ygwsx@126.com [Jiangsu Laboratory of Advanced Functional Materials, Department of Chemistry and Materials Engineering, Changshu Institute of Technology, Changshu 215500, Jiangsu (China); Shen Lei; Zhai Chun; Shen Wei; Gu Kun; Zhao Jingjing [Jiangsu Laboratory of Advanced Functional Materials, Department of Chemistry and Materials Engineering, Changshu Institute of Technology, Changshu 215500, Jiangsu (China)

    2012-06-15

    Reactions of 1H-tetrazolate-5-acetic acid(H{sub 2}tza) with Nd(NO{sub 3}){sub 3}{center_dot}6H{sub 2}O or Dy(NO{sub 3}){sub 3}{center_dot}6H{sub 2}O with the presence of KOH under solvothermal conditions, produced two new coordination compounds, [M{sub 2}(tza){sub 3}(H{sub 2}O){sub 6}]{center_dot}2H{sub 2}O [M=Nd(1), Dy(2)]. Both compounds were structurally characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. Compounds 1 and 2 reveal 1D structures via bridging tza as linker. Furthermore, the compounds 1 and 2 showed a specific and good catalytic behavior for the polymerization of styrene, and the polymerization showed controlled characteristics. - Graphical Abstract: Two new coordination compounds, [M{sub 2}(tza){sub 3}(H{sub 2}O){sub 6}]{center_dot}2H{sub 2}O [M=Nd(1), Dy(2)] have been synthesis. 1 and 2 reveal 1D structures via bridging tza as linker, and showed a specific and good catalytic behavior for the polymerization of styrene. Highlights: Black-Right-Pointing-Pointer we have reported two novel compounds formed by H{sub 2}tza and Nd(III) or Dy(III). Black-Right-Pointing-Pointer Compounds 1 and 2 were found to have catalysis property for the photo-polymerization of styrene. Black-Right-Pointing-Pointer The high molecular weight polymers with narrow molecular weight distributions were obtained.

  18. Amyotrophic lateral sclerosis-like presentation in a HIV-positive patient.

    Science.gov (United States)

    Anand, Kuljeet Singh; Wadhwa, Ankur; Garg, Jyoti; Mahajan, Rakesh Kumar

    2014-01-01

    There has been several reports of an MND like syndrome in HIV-1 infection, however the data is still sparse. Furthermore, HIV-associated amyotrophic lateral sclerosis (ALS) syndrome differs from the classical ALS in some key aspects.. A 44-year-old male presented with a history of insidious onset and gradually progressive asymmetric weakness of lower limbs. He also complained of thinning in both legs, the left leg more than the right since 1 year along with spontaneous twitching of muscles in both the thighs. On neurological examination, the assessment of higher mental functions was normal. There were no cranial nerve deficits. Motor power was grade 5/5 (Medical Research Council scale) in both the upper limbs and 4+ at hips and knees bilaterally, 5 at right ankle, and 4+ at left ankle. All the deep tendon reflexes were brisk with extensor planter responses. There were no cerebellar signs or sensory deficits. HIV-1 was reactive in enzyme-linked immunosorbent assay. Electrophysiological studies were conducted per the MND protocol.None of the nerves studied showed an abnormal drop in compound muscle action potential amplitude with proximal stimulation. There was evidence of diffuse spontaneous activity, which manifests as fibrillation and fasciculation potentials in most muscles tested . Overall there seems to be sufficient evidence to implicate HIV as a potential cause of an ALS-like disorder, but one must also consider the possibility of coincidental HIV infection in patients who have sporadic ALS. © The Author(s) 2014.

  19. Defense at Low Force Levels: The Effect of Force to Space Ratios on Conventional Combat Dynamics

    Science.gov (United States)

    1991-08-01

    attempted falsification , or to answer the kinds of detailed questions that emerged once the policy community discovered the issue. How strong is the...Pat I," Milk =x.eview. September 1985, pp. 35-36.3 12CJ. Dick, ’Soviet Operational Art, Part I: The Fruits of Experience," IDR No. 7,1988, pp. 759-760...2,1989, p. 141. 3 14 DaiM M. Glantz, "Operational Art mnd Tactcs," Milk = Review, December 1988, pp. 37-38. 151bid, p. 39. 3 16 C.N. Donnelly, "The

  20. The challenges of dysphagia in treating motor neurone disease.

    Science.gov (United States)

    Vesey, Siobhan

    2017-07-01

    Motor neurone disease (MND) is a relatively rare degenerative disorder. Its impacts are manifested in progressive loss of motor function and often accompanied by wider non-motor changes. Swallowing and speech abilities are frequently severely impaired. Effective management of dysphagia (swallowing difficulty) symptoms and nutritional care requires a holistic multidisciplinary approach. Care must be patient focused, facilitate patient decision making, and support planning towards end of life care. This article discusses the challenges of providing effective nutritional care to people living with motor neurone disease who have dysphagia.

  1. Mood and quality of life among people with progressive neurological illnesses

    OpenAIRE

    Marita P. McCabe; Lucy Firth; Elodie O´Connor

    2009-01-01

    El presente estudio ex post facto fue diseñado para examinar el estado de ánimo y la calidad de vida (QQL) entre 423 personas con enfermedad neurológica progresiva. En particular, se ha investigado la relación entre las variables de la enfermedad y el estado de ánimo y calidad de vida de 120 personas con enfermedad de la neuronales motoras (MND), 48 con enfermedad de Huntington (HD), 143 con Parkinson y 112 con esclerosis múltiple (MS). Los resultados demostraron que las personas con HD co...

  2. Bakterite Miss Marple = The Miss Marple of bacteria / Marika Mikelsaar ; interv. Evelin Kivilo

    Index Scriptorium Estoniae

    Mikelsaar, Marika, 1938-

    2008-01-01

    Intervjuu Tartu Ülikooli professori, probiootilise piimhappebakteri ME-3 avastajaga, kes pälvis president Toomas Hendrik Ilveselt Eesti Vabariigi 90. aastapäeva puhul Valgetähe III klassi teenetemärgi

  3. Earth Science Data for a Mobile Age

    Science.gov (United States)

    Oostra, D.; Chambers, L. H.; Lewis, P. M.; Baize, R.; Oots, P.; Rogerson, T.; Crecelius, S.; Coleman, T.

    2012-12-01

    Earth science data access needs to be interoperable and automatic. Recently, increasingly savvy data users combined with more complex web and mobile applications have placed increasing demands on how this Earth science data is being delivered to educators and students. The MY NASA DATA (MND) and S'COOL projects are developing a strategy to interact with the education community in the age of mobile devices and platforms. How can we provide data and meaningful scientific experiences to educational users through mobile technologies? This initiative will seek out existing technologies and stakeholders within the Earth Science community to identify datasets that are relevant and appropriate for mobile application development and use by the educational community. Targeting efforts within the educational community will give the project a better understanding of the previous attempts at data/mobile application use in the classroom and its problems. In addition, we will query developers and data providers on what successes and failures they've experienced in trying to provide data for applications designed on mobile platforms. This feedback will be implemented in new websites, applications and lessons that will provide authentic scientific experiences for students and end users. We want to create tools that help sort through the vast amounts of NASA data, and deliver it to users automatically. NASA provides millions of gigabytes of data that is publicly available through a large number of services spread across the World Wide Web. Accessing and navigating this data can be time consuming and problematic with variety of file types and methods for accessing this data. The MND project, through its' Live Access Server system, provides selected datasets that are relevant and targets National Standards of Learning for educators to easily integrate into existing curricula. In the future, we want to provide desired data to users with automatic updates, anticipate future data queries

  4. Structure- and cell-specific effects of imidoselenocarbamates on selenoprotein expression and activity in liver cells in culture.

    Science.gov (United States)

    Ibáñez, Elena; Stoedter, Mette; Hofmann, Peter Josef; Plano, Daniel; Calvo, Alfonso; Nguewa, Paul A; Palop, Juan Antonio; Sanmartín, Carmen; Schomburg, Lutz

    2012-12-01

    The essential micronutrient selenium (Se) exerts its biological effects mainly through selenoproteins thereby affecting a number of physiological pathways including intracellular redox control, stress response and cancer cell proliferation. Besides affecting selenoprotein expression, some selenocompounds have been synthesized and analyzed in order to serve as chemotherapeutic substances preferentially targeting cancer cells. This promising chemotherapeutic potential has recently been verified for a particular imidoselenocarbamate in a mouse tumor model. In the present study we tested the effects of this and a number of related Se-methyl- and Se-benzyl-imidoselenocarbamates on selenoprotein expression in nontransformed and hepatic carcinoma cells in culture. Most of the Se-benzyl-imidoselenocarbamates strongly stimulated selenoprotein P (SePP) secretion while the Se-methyl-imidoselenocarbamates elicited less pronounced effects in hepatocarcinoma HepG2 cells. However, most of the Se-methyl-imidoselenocarbamates increased glutathione peroxidase (GPx) activity and decreased thioredoxin reductase (TXNRD) activity in parallel, while the majority of the Se-benzyl-imidoselenocarbamates were without a respective effect in HepG2 cells. Performing inhibitor assays in vitro, GPx activity was unaffected by the imidoselenocarbamates. In contrast, most of the Se-methyl-imidoselenocarbamates inhibited TXNRD activity in vitro in line with the results in HepG2 cells. Both classes of imidoselenocarbamates strongly induced selenoprotein S (SELS) expression without a respective increase in ER stress or unfolded protein response which are known inducers of SELS biosynthesis. Notably, many of these effects were cancer cell-specific, and not observed in nontransformed AML12 hepatocytes. Our results indicate that these novel selenocompounds affect expression and activity of crucial selenoenzymes in a compound- and cell-specific way in hepatocytes. Especially the Se

  5. Avaliku võimu ja kodanikualgatuse partnerlus : koostööd mõjutavad tegurid / Krista Hinno, Tanel Vallimäe

    Index Scriptorium Estoniae

    Hinno, Krista

    2007-01-01

    Artiklis esitatakse kokkuvõte Tallinna Ülikooli Eesti Humanitaarinstituudi Kodanikeühiskonna Uurimis- ja Arenduskeskuse uurimuse "Avaliku võimu ja kodanikualgatuse komplementaarsed suhted" peamistest tulemustest. Raporti autorite hulka kuulusid Erle Rikmann, Krista Hinno, Aigi Bremse, Kersti Kollom, Mari Sepp ja Tanel Vallimäe. Toetudes uuringutele väidavad autorid, et Eesti ametnikkond on soodsalt meelestatud koostööle kodanikuühendustega, takistuseks võivad saada kodanikeühenduste erinev tööstiil, vajalike ressursside puudus, sh ka ajanappus, ametnike kaadrivoolavus ja teatavate vanusegruppide vähene avatus. Diagrammid: Koostöö jaotumine asutuseliikide vahel; Ametnike hinnang ühistegevuse sisukusele seoses koostöö algatamisega; Ametnike hinnang omaduse vajalikkusele oma töös (vastajate osakaal, kes peavad antud omadust oma töös väga vajalikuks)

  6. [Personalizing the reference level: gold standard to evaluate the quality of service perceived].

    Science.gov (United States)

    Rodrigo-Rincón, I; Reyes-Pérez, M; Martínez-Lozano, M E

    2014-01-01

    To know the cutoff point at which in-house Nuclear Medicine Department (MND) customers consider that the quality of service is good (personalized cutoff). We conducted a survey of the professionals who had requested at least 5 tests to the Nuclear Medicine Department. A total of 71 doctors responded (response rate: 30%). A question was added to the questionnaire for the user to establish a cutoff point for which they would consider the quality of service as good. The quality non-conformities, areas of improvement and strong points of the six questions measuring the quality of service (Likert scale 0 to 10) were compared with two different thresholds: personalized cutoff and one proposed by the service itself a priori. Test statistics: binomial and Student's t-test for paired data. A cutoff value of 7 was proposed by the service as a reference while 68.1% of respondents suggested a cutoff above 7 points (mean 7.9 points). The 6 elements of perceived quality were considered strong points with the cutoff proposed by the MND, while there were 3 detected with the personalized threshold. Thirteen percent of the answers were nonconformities with the service cutoff versus 19.2% with the personalized one, the differences being statistically significant (difference 95% CI 6.44%:0,83-12.06). The final image of the perceived quality of an in-house customer is different when using the cutoff established by the Department versus the personalized cutoff given by the respondent. Copyright © 2013 Elsevier España, S.L. and SEMNIM. All rights reserved.

  7. Clinical and Neuropsychological Characteristics of a Nationwide Hospital-Based Registry of Frontotemporal Dementia Patients in Korea: A CREDOS-FTD Study

    Directory of Open Access Journals (Sweden)

    Eun-Joo Kim

    2014-07-01

    Full Text Available Background: We investigated the demographic, clinical, and neuropsychological characteristics of frontotemporal dementia (FTD from the Clinical Research Center for Dementia of South Korea (CREDOS-FTD registry. Methods: A total of 200 consecutive patients with FTD recruited from 16 neurological clinics in Korea were evaluated by cognitive and functional assessments, a screening test for aphasia, behavioral questionnaires, motor assessments, and brain MRI or PET. Results: In our registry, 78 patients were classified as having been diagnosed with behavioral-variant FTD (bvFTD, 70 with semantic dementia (SD, 33 with progressive nonfluent aphasia (PNFA, and 8 with motor neuron disease plus syndrome (MND-plus. The patients with language variants of dementia were older than those with bvFTD. There were no differences in sex ratio, duration of illness, or level of education among the four subgroups. Overall, the patients with bvFTD showed a significantly better performance in cognitive tests. A higher frequency of motor symptoms and a lower frequency of behavioral symptoms were found in PNFA than in bvFTD and SD. The Global Language Index was significantly lower in SD than in bvFTD and PNFA. The MND-plus group had a poorer performance than all the others in all cognitive domains. Conclusion: The neuropsychological, behavioral, motor, and language characteristics of the four subtypes are comparable with those from other series. However, the proportion of SD (37.0%, which was similar to that of bvFTD (41.3%, was higher in our registry than in other series.

  8. Vaata mulle näkku: mu nimi on Oleks Võinud Olla / Andreas Sepp

    Index Scriptorium Estoniae

    Sepp, Andreas

    2011-01-01

    Tallinna Fotokuu raames Kumu Kunstimuuseumis rahvusvaheline kaamerakunsti näitus "Teisele poole" 7.10.2011-08.01.2012, kuraator Adam Budak Osaleb 19 kunstnikku, neist tutvustatakse: John Baldessari (California), Sunah Choi (Korea), Haris Epaminonda (Küpros), Helena Almeida (Portugal), Elad Lassry (Iisrael), Alexandre Singh (Prantsusmaa)

  9. Reklaamitööstus teeb naise kehast universaalse märgi / Veljo Sepp

    Index Scriptorium Estoniae

    Sepp, Veljo

    2005-01-01

    Piret Räni ühiskonnakriitiline näitus "Hello friend, are you impotent?" Eesti Kunstiakadeemia galeriis. Näha digitrükis kollaazhipannood ning fotouurimus naise keha kasutamisest ruumis ja meedias

  10. Balti kunstnike näitus AABS-i konverentsil : Tulving, Tamasauskas, Ingelevics / Eda Sepp

    Index Scriptorium Estoniae

    Sepp, Eda

    2004-01-01

    Tartu College'i saalis Torontos on 3. - 6. juunini 2004 avatud kunstinäitus, kus saab vaadata Rutt Tulvingu serigraafiasarja "What is Man", välisleedulase Otis Tamasauskase suuremõõtmelist graafikat ning välislätlase Ingelevicsi videoinstallatsiooni

  11. Endale lisatasu maksnud Seeder vallandas sama teo eest alluva / Mehis Tulk, Andres Sepp

    Index Scriptorium Estoniae

    Tulk, Mehis, 1967-

    2008-01-01

    Taimetoodangu Inspektsiooni peadirektori kohalt vallandatud Mart Mäeker käib kohut põllumajandusministeeriumiga ja on hämmeldunud ministeeriumis valitsevast topeltmoraalist tulemustasude määramisel ja põllumajandusminister Helir-Valdor Seederi käitumisest. Vt. samas: Kaire Uusen. Ministrite suud jäid lukku

  12. HIV-i võib nakatunud olla iga sajas täiskasvanud eestlane / Marika Raiski

    Index Scriptorium Estoniae

    Raiski, Marika

    2005-01-01

    Vt. ka Nädaline 27. sept., lk. 7. Vastavalt Maailma Terviseorganisatsiooni (WHO) ja UNAIDS-i hinnangule on Eestis hulgaliselt registreerimata HIV-juhte ning tegelikult võib HIV-nakatunuid olla juba iga sajas täiskasvanud Eesti elanik

  13. Prevalence and predictors of post-stroke mood disorders: A meta-analysis and meta-regression of depression, anxiety and adjustment disorder.

    Science.gov (United States)

    Mitchell, Alex J; Sheth, Bhavisha; Gill, John; Yadegarfar, Motahare; Stubbs, Brendon; Yadegarfar, Mohammad; Meader, Nick

    2017-07-01

    To ascertain the prevalence and predictors of mood disorders, determined by structured clinical interviews (ICD or DSM criteria) in people after stroke. Major electronic databases were searched from inception to June 2016 for studies involving major depression (MDD), minor depression (MnD), dysthymia, adjustment disorder, any depressive disorder (any depressive disorder) and anxiety disorders. Studies were combined using both random and fixed effects meta-analysis and results were stratified as appropriate. Depression was examined on 147 occasions from 2days to 7years after stroke (mean 6.87months, N=33 in acute, N=43 in rehabilitation and N=69 in the community/outpatients). Across 128 analyses involving 15,573 patients assessed for major depressive disorder (MDD), the point prevalence of depression was 17.7% (95% CI=15.6% to 20.0%) 0.65 analyses involving 9720 patients determined MnD was present in 13.1% in all settings (95% CI=10.9% to 15.8%). Dysthymia was present in 3.1% (95% CI=2.1% to 5.3%), adjustment disorder in 6.9% (95% CI=4.6 to 9.7%) and anxiety in 9.8% (95% CI=5.9% to 14.8%). Any depressive disorder was present in 33.5% (95% CI=30.3% to 36.8%). The relative risk of any depressive disorder was higher following left (dominant) hemisphere stroke, aphasia, and among people with a family history and past history of mood disorders. Depression, adjustment disorder and anxiety are common after stroke. Risk factors are aphasia, dominant hemispheric lesions and past personal/family history of depression but not time since stroke. Copyright © 2017. Published by Elsevier Inc.

  14. Mortality from multiple sclerosis in British military personnel.

    Science.gov (United States)

    Harris, E Clare; Palmer, Keith T; Cox, Vanessa; Darnton, Andrew; Osman, John; Coggon, David

    2017-08-01

    While analysing trends in occupational mortality in England and Wales, we noticed an unexpectedly elevated proportion of deaths from multiple sclerosis (MS) among men in the armed forces. To document and explore possible explanations for the observed excess. We analysed data on underlying cause of death and last full-time occupation for 3,688,916 deaths among men aged 20-74 years in England and Wales during 1979-2010, calculating proportional mortality ratios (PMRs) standardised for age. We compared PMRs for MS in the armed forces with those for each main social class, and in selected other occupations. We also compared PMRs for MS with those for motor neurone disease (MND). The overall PMR for MS in the armed forces during 1979-2010 was 243 (95%CI 203-288). The excess was apparent in each of three separate decades of study (PMRs, ranging from 220 to 259), and across the entire age range. PMRs for MS were not elevated to the same extent in comparator occupations, nor in any of the main social classes. There was no parallel increase in PMRs for MND. These findings suggest that the high proportional mortality from MS in British military personnel is unlikely to have occurred by chance, or as an artefact of the method of investigation. However, the only military cohort study with published results on MS does not support an increased risk. It would be useful to analyse data on MS from other established military cohorts, to check for evidence of a hazard. © The Author 2017. Published by Oxford University Press on behalf of the Society of Occupational Medicine.

  15. Regionaalsete toetusprogrammide mõju kohalike omavalitsuste arengule / Monica Hankov, Jüri Sepp, Siret Vildo

    Index Scriptorium Estoniae

    Hankov, Monica

    2004-01-01

    Analüüsi tulemustest selgus, et vaatamata toetusprogrammide rakendamisele ei ole regionaalsed erinevused Eesti piirkondade vahel vähenenud. Diagramm. Tabelid. Lisa: EAS regionaalprogrammide sihtalad, nende eripärad ja arengueeldused

  16. Support of small and medium sized enterprises in Estonia / Jüri Sepp, Monica Hankov

    Index Scriptorium Estoniae

    Sepp, Jüri

    2003-01-01

    Ettevõtjate seas läbiviidud uuringust selgus, et ettevõtjad hindavad väikeettevõtluse toetuspoliitikat nõrgaks ja ebaefektiivseks; peavad finantseerimise taotlemisel suurimateks probleemideks liiga kõrgeid intressimäärasid, bürokraatiat ja nõrka konkurentsi pangandussektoris; peavad oluliseks koostöö parandamist avaliku ja erasektori vahel.Tabelid. Diagrammid

  17. August Anni(sti) rahvuslik-demokraatlik kultuuriideaal Eesti Vabariigi algusaastail ja vaikival ajastul / Helena Sepp

    Index Scriptorium Estoniae

    Sepp, Helena, 1964-

    2008-01-01

    Rahvaluuledoktor August Anni(sti) rahvuslikust kultuurinägemusest ja -visioonist ning suhtumisest natsionalismi, sotsialismi ja demokraatiasse. Allikatena on kasutatud Anni(sti) artikleid, mis ilmusid vaadeldava perioodi kogumikes ja ajakirjanduses

  18. Sharing and Empathy in Digital Spaces: Qualitative Study of Online Health Forums for Breast Cancer and Motor Neuron Disease (Amyotrophic Lateral Sclerosis).

    Science.gov (United States)

    Hargreaves, Sarah; Bath, Peter A; Duffin, Suzanne; Ellis, Julie

    2018-06-14

    The availability of an increasing number of online health forums has altered the experience of living with a health condition, as more people are now able to connect and support one another. Empathy is an important component of peer-to-peer support, although little is known about how empathy develops and operates within online health forums. The aim of this paper is to explore how empathy develops and operates within two online health forums for differing health conditions: breast cancer and motor neuron disease (MND), also known as amyotrophic lateral sclerosis. This qualitative study analyzed data from two sources: interviews with forum users and downloaded forum posts. Data were collected from two online health forums provided by UK charities: Breast Cancer Care and the Motor Neurone Disease Association. We analyzed 84 threads from the breast cancer forum and 52 from the MND forum. Threads were purposively sampled to reflect varied experiences (eg, illness stages, topics of conversation, and user characteristics). Semistructured interviews were conducted with 14 Breast Cancer Care forum users and five users of the MND forum. All datasets were analyzed thematically using Braun and Clarke's six-phase approach and combined to triangulate the analysis. We found that empathy develops and operates through shared experiences and connections. The development of empathy begins outside the forum with experiences of illness onset and diagnosis, creating emotional and informational needs. Users came to the forum and found their experiences and needs were shared and understood by others, setting the empathetic tone and supportive ethos of the forum. The forum was viewed as both a useful and meaningful space in which they could share experiences, information, and emotions, and receive empathetic support within a supportive and warm atmosphere. Empathy operated through connections formed within this humane space based on similarity, relationships, and shared feelings. Users

  19. Žürii kommenteerib Kultuurkapitali arhitektuuripreemiaid 2008 / Marika Lõoke, Laila Põdra, Liina Jänes... [jt.

    Index Scriptorium Estoniae

    2009-01-01

    Peapreemia: Markus Kaasik, Andres Ojari, Ilmar Valdur, Mihkel Tüür, Kalle Komissarov (Pärnu Keskraamatukogu hoone), tegevuspreemia: Maarja Kask, Ralf Lõoke, Neeme Külm, Ingrid Ruudi (projekt Gaasitoru 11. Veneetsia arhitektuuribiennaalil), aastapreemia: Maarja Kask, Ralf Lõoke, Karli Luik (Tartu Kesklinna Kooli juurdeehitus) ja Peep Jänes (Raudna Põhikooli spordihoone), sisearhitektuuri preemia: Tea Tammelaan, Malle Jürgenson, Krista Lepland, restaureerimispreemia: Mari Hammer, Tiiu Lõhmus, Helve Ilves, Villu Kadakas (Vanalinna Hariduskolleegiumi hoone)

  20. Archaeological excavations at Viltina - a viking age harbour site and meeting place / Marika Mägi

    Index Scriptorium Estoniae

    Mägi, Marika, 1968-

    2007-01-01

    2006 jätkusid kaevamised Viltina viikingiaegsel sadamakohal, millega oli alustatud juba 2004. aastal. Kaevati läbi 327,25 m2. Suuremas osas kaevandites paljandunud kiht on vaieldamatult asulakiht. Viltina asulakihiga aladel leidus tavapärasest asulakihist tunduvalt rohkem metall-leide. Leidudest. Tõenäoliselt oli sadamakoht kasutusajal piiratud taraga

  1. How integrated are neurology and palliative care services? Results of a multicentre mapping exercise.

    Science.gov (United States)

    van Vliet, Liesbeth M; Gao, Wei; DiFrancesco, Daniel; Crosby, Vincent; Wilcock, Andrew; Byrne, Anthony; Al-Chalabi, Ammar; Chaudhuri, K Ray; Evans, Catherine; Silber, Eli; Young, Carolyn; Malik, Farida; Quibell, Rachel; Higginson, Irene J

    2016-05-10

    Patients affected by progressive long-term neurological conditions might benefit from specialist palliative care involvement. However, little is known on how neurology and specialist palliative care services interact. This study aimed to map the current level of connections and integration between these services. The mapping exercise was conducted in eight centres with neurology and palliative care services in the United Kingdom. The data were provided by the respective neurology and specialist palliative care teams. Questions focused on: i) catchment and population served; ii) service provision and staffing; iii) integration and relationships. Centres varied in size of catchment areas (39-5,840 square miles) and population served (142,000-3,500,000). Neurology and specialist palliative care were often not co-terminus. Service provisions for neurology and specialist palliative care were also varied. For example, neurology services varied in the number and type of provided clinics and palliative care services in the settings they work in. Integration was most developed in Motor Neuron Disease (MND), e.g., joint meetings were often held, followed by Parkinsonism (made up of Parkinson's Disease (PD), Multiple-System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP), with integration being more developed for MSA and PSP) and least in Multiple Sclerosis (MS), e.g., most sites had no formal links. The number of neurology patients per annum receiving specialist palliative care reflected these differences in integration (range: 9-88 MND, 3-25 Parkinsonism, and 0-5 MS). This mapping exercise showed heterogeneity in service provision and integration between neurology and specialist palliative care services, which varied not only between sites but also between diseases. This highlights the need and opportunities for improved models of integration, which should be rigorously tested for effectiveness.

  2. Quantum many-body effects in x-ray spectra efficiently computed using a basic graph algorithm

    Science.gov (United States)

    Liang, Yufeng; Prendergast, David

    2018-05-01

    The growing interest in using x-ray spectroscopy for refined materials characterization calls for an accurate electronic-structure theory to interpret the x-ray near-edge fine structure. In this work, we propose an efficient and unified framework to describe all the many-electron processes in a Fermi liquid after a sudden perturbation (such as a core hole). This problem has been visited by the Mahan-Noziéres-De Dominicis (MND) theory, but it is intractable to implement various Feynman diagrams within first-principles calculations. Here, we adopt a nondiagrammatic approach and treat all the many-electron processes in the MND theory on an equal footing. Starting from a recently introduced determinant formalism [Phys. Rev. Lett. 118, 096402 (2017), 10.1103/PhysRevLett.118.096402], we exploit the linear dependence of determinants describing different final states involved in the spectral calculations. An elementary graph algorithm, breadth-first search, can be used to quickly identify the important determinants for shaping the spectrum, which avoids the need to evaluate a great number of vanishingly small terms. This search algorithm is performed over the tree-structure of the many-body expansion, which mimics a path-finding process. We demonstrate that the determinantal approach is computationally inexpensive even for obtaining x-ray spectra of extended systems. Using Kohn-Sham orbitals from two self-consistent fields (ground and core-excited state) as input for constructing the determinants, the calculated x-ray spectra for a number of transition metal oxides are in good agreement with experiments. Many-electron aspects beyond the Bethe-Salpeter equation, as captured by this approach, are also discussed, such as shakeup excitations and many-body wave function overlap considered in Anderson's orthogonality catastrophe.

  3. A case report of motor neuron disease in a patient showing significant level of DDTs, HCHs and organophosphate metabolites in hair as well as levels of hexane and toluene in blood

    International Nuclear Information System (INIS)

    Kanavouras, Konstantinos; Tzatzarakis, Manolis N.; Mastorodemos, Vasileios; Plaitakis, Andreas; Tsatsakis, Aristidis M.

    2011-01-01

    Motor neuron disease is a devastating neurodegenerative condition, with the majority of sporadic, non-familial cases being of unknown etiology. Several epidemiological studies have suggested that occupational exposure to chemicals may be associated with disease pathogenesis. We report the case of a patient developing progressive motor neuron disease, who was chronically exposed to pesticides and organic solvents. The patient presented with leg spasticity and developed gradually clinical signs suggestive of amyotrophic lateral sclerosis, which was supported by the neurophysiologic and radiological findings. Our report is an evidence based case of combined exposure to organochlorine (DDTs), organophosphate pesticides (OPs) and organic solvents as confirmed by laboratory analysis in samples of blood and hair confirming systematic exposure. The concentration of non-specific dialkylphosphates metabolites (DAPs) of OPs in hair (dimethyphopshate (DMP) 1289.4 pg/mg and diethylphosphate (DEP) 709.4 pg/mg) and of DDTs (opDDE 484.0 pg/mg, ppDDE 526.6 pg/mg, opDDD 448.4 pg/mg, ppDDD + opDDT 259.9 pg/mg and ppDDT 573.7 pg/mg) were considerably significant. Toluene and n-hexane were also detected in blood on admission at hospital and quantified (1.23 and 0.87 μg/l, respectively), while 3 months after hospitalization blood testing was found negative for toluene and n-hexane and hair analysis was provided decrease levels of HCHs, DDTs and DAPs. -- Highlights: ► Exposure to pesticides and organic solvents might be a risk factor for sporadic MND. ► We report a patient who developed progressive upper and lower motor neuron disease. ► The patient had a history of occupational exposure to pesticides and solvents. ► High DDTs’ levels and increased levels of DMP and DEP were measured in his hair. ► The patients’ exposure to chemicals might have played a role in MND development.

  4. Needs of informal caregivers across the caregiving course in amyotrophic lateral sclerosis: a qualitative analysis

    Science.gov (United States)

    Carney, Sile; Corr, Bernie; Mays, Iain; Pender, Niall; Hardiman, Orla

    2018-01-01

    Objectives Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a debilitating terminal condition. Informal caregivers are key figures in ALS care provision. The physical, psychological and emotional impact of providing care in the home requires appropriate assistance and support. The objective of this analysis is to explore the needs of informal ALS caregivers across the caregiving course. Design In an open-ended question as part of a semistructured interview, caregivers were asked what would help them in their role. Interviews took place on three occasions at 4-month to 6-month intervals. Demographic, burden and quality of life data were collected, in addition to the open-ended responses. We carried out descriptive statistical analysis and thematic analysis of qualitative data. Setting and participants Home interviews at baseline (n=81) and on two further occasions (n=56, n=41) with informal caregivers of people with ALS attending the National ALS/MND Clinic at Beaumont Hospital, Dublin, Ireland. Results The majority of caregivers were family members. Hours of care provided and caregiver burden increased across the interview series. Thematic analysis identified what would help them in their role, and needs related to external support and services, psychological-emotional factors, patient-related behaviours, a cure and ‘nothing’. Themes were interconnected and their prevalence varied across the interview time points. Conclusion This study has shown the consistency and adaptation in what caregivers identified as helpful in their role, across 12–18 months of a caregiving journey. Support needs are clearly defined, and change with time and the course of caregiving. Caregivers need support from family, friends and healthcare professionals in managing their tasks and the emotional demands of caregiving. Identifying the specific needs of informal caregivers should enable health professionals to provide tailored supportive interventions

  5. Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes

    Directory of Open Access Journals (Sweden)

    Kyoung-in Cho

    2017-05-01

    Full Text Available The pathogenic drivers of sporadic and familial motor neuron disease (MND, such amyotrophic lateral sclerosis (ALS, are unknown. MND impairs the Ran GTPase cycle, which controls nucleocytoplasmic transport, ribostasis and proteostasis; however, cause-effect mechanisms of Ran GTPase modulators in motoneuron pathobiology have remained elusive. The cytosolic and peripheral nucleoporin Ranbp2 is a crucial regulator of the Ran GTPase cycle and of the proteostasis of neurological disease-prone substrates, but the roles of Ranbp2 in motoneuron biology and disease remain unknown. This study shows that conditional ablation of Ranbp2 in mouse Thy1 motoneurons causes ALS syndromes with hypoactivity followed by hindlimb paralysis, respiratory distress and, ultimately, death. These phenotypes are accompanied by: a decline in the nerve conduction velocity, free fatty acids and phophatidylcholine of the sciatic nerve; a reduction in the g-ratios of sciatic and phrenic nerves; and hypertrophy of motoneurons. Furthermore, Ranbp2 loss disrupts the nucleocytoplasmic partitioning of the import and export nuclear receptors importin β and exportin 1, respectively, Ran GTPase and histone deacetylase 4. Whole-transcriptome, proteomic and cellular analyses uncovered that the chemokine receptor Cxcr4, its antagonizing ligands Cxcl12 and Cxcl14, and effector, latent and activated Stat3 all undergo early autocrine and proteostatic deregulation, and intracellular sequestration and aggregation as a result of Ranbp2 loss in motoneurons. These effects were accompanied by paracrine and autocrine neuroglial deregulation of hnRNPH3 proteostasis in sciatic nerve and motoneurons, respectively, and post-transcriptional downregulation of metalloproteinase 28 in the sciatic nerve. Mechanistically, our results demonstrate that Ranbp2 controls nucleocytoplasmic, chemokine and metalloproteinase 28 signaling, and proteostasis of substrates that are crucial to motoneuronal homeostasis and

  6. Organizational Structure in Korea's Nuclear Energy Development

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J. H.; Lee, T. J. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2012-05-15

    This paper explores the cross-sectional and dynamic analysis of nuclear related organizations in Korea to systemize them. Nuclear related organizations in Korea are classified into four large groups as commission, executive branch, public institution and private organization. Table 1 shows the nuclear related organizations in each group. AEC, NSC and their expert commission are all the commissions on nuclear energy. MEST, MKE, MFAT, MND etc. are executive branch related to nuclear energy. In addition, there are also government affiliated agencies, societies, associations and other different types of organizations carrying out tasks entrusted by the government concerning nuclear R and D and safety regulation. As for nuclear related private organizations, there are KEPCO, KHNP, KEPCO-ENC, KEPCO-NF etc

  7. Carnitine prevents the early mitochondrial damage induced by methylglyoxal bis(guanylhydrazone) in L1210 leukaemia cells.

    Science.gov (United States)

    Nikula, P; Ruohola, H; Alhonen-Hongisto, L; Jänne, J

    1985-06-01

    We previously found that the anti-cancer drug methylglyoxal bis(guanylhydrazone) (mitoguazone) depresses carnitine-dependent oxidation of long-chain fatty acids in cultured mouse leukaemia cells [Nikula, Alhonen-Hongisto, Seppänen & Jänne (1984) Biochem. Biophys. Res. Commun. 120, 9-14]. We have now investigated whether carnitine also influences the development of the well-known mitochondrial damage produced by the drug in L1210 leukaemia cells. Palmitate oxidation was distinctly inhibited in tumour cells exposed to 5 microM-methylglyoxal bis(guanylhydrazone) for only 7 h. Electron-microscopic examination of the drug-exposed cells revealed that more than half of the mitochondria were severely damaged. Similar exposure of the leukaemia cells to the drug in the presence of carnitine not only abolished the inhibition of fatty acid oxidation but almost completely prevented the drug-induced mitochondrial damage. The protection provided by carnitine appeared to depend on the intracellular concentration of methylglyoxal bis(guanylhydrazone), since the mitochondria-sparing effect disappeared at higher drug concentrations.

  8. ECOLOGICAL APPROACHES IN THE ORGANIC AGRICULTURAL SYSTEM

    Directory of Open Access Journals (Sweden)

    Veselka Vlahova

    2015-09-01

    Full Text Available The permaculture includes landscape shaping, terrace formation, establishment of raised planes and hilly beds. Sepp Holzer’s permaculture has been practices since 1962, having its followers in Columbia, Thailand, Brazil, the USA and Scotland, etc. Important specifics of the Fukuoka method consists of the requirement that the agricultural farm is close to nature, without any attempts to conquer or improve it, whence the method’s name “natural”, i.e. real or natural. In his book entitled “The One-Straw Revolution” the author examines the issues of natural agriculture. The Biodynamic French Intensive method of vegetable gardening combines two gardening traditions: biodynamics, created in the 1920s by Rudolph Steiner, and French intensive gardening, a method practiced by 19th century farmers on the outskirts of Paris. British horticulturist Alan Chadwick bought these methods to the United States in the 1960s and coined the term biointensive. This style of organic gardening focuses on sustainable, high productivity using minimal space.

  9. Alzheimeri tõve vastu võib olla leitud ravim / Villu Päärt, Siim Sepp

    Index Scriptorium Estoniae

    Päärt, Villu, 1972-

    2008-01-01

    Austraalia teadlaste juhitud töös uuriti vask- ja tsinkioone siduva ravimi PBT2 mõju AB-ladestusele, mis tekivad transgeensete, nn Alzheimeri hiirte ajus. Hiirtel täheldati juba paari päeva möödudes ajutegevuse paranemist

  10. Kuriteoohvrite abistamisest Eestis : [bakalaureusetöö] / Gerda Sepp ; Tartu Ülikool, õigusteaduskond ; juhendaja: Silvia Kaugia

    Index Scriptorium Estoniae

    Sepp, Gerda

    2009-01-01

    Viktimoloogia mõistest ja olemusest, kuritegevusest Eestis viimasel viiel aastal, kuriteo negatiivsest mõjust selle ohvrile, ohvrite reaalsetest võimalustest abisaamiseks praeguses Eestis, hinnangust ohvriabi süsteemile Eestis

  11. Die aktuelle Position Estlands im internationalen Steuerwettbewerb : empirische Ergebnisse / Jüri Sepp, Ralph M Wrobel

    Index Scriptorium Estoniae

    Sepp, Jüri

    2003-01-01

    Olulisematest trendidest ja Eesti positsioonist rahvusvahelises maksukonkurentsis nii maksukoormuse, maksude struktuuri kui ka vastavuse mõttes ausa (mittediskrimineeriva) konkurentsi reeglitele. Tabelid

  12. Competition creation and regulation in case of Estonian competition policy / Diana Eerma, Jüri Sepp

    Index Scriptorium Estoniae

    Eerma, Diana, 1964-

    2006-01-01

    Riikliku reguleerimise peaeesmärgiks on suurendada majanduslikku ja sotsiaalset heaolu ning luua makro- ja mikromajanduslik keskkond selleks, et kindlustada ettevõtete konkurentsivõime. Eesti konkurentsipoliitika näitel analüüsitakse konkurentsi loomist ja riiklikku reguleerimist turule sisenemisel

  13. Eesti merovingi- ja viikingiaegsed rinnanõelad - võõrapärased ja omad / Marika Mägi

    Index Scriptorium Estoniae

    Mägi, Marika

    1997-01-01

    Artiklis käsitletakse Eesti merovingi- ja viikingiaegsete ehtenõelte tüpoloogiat ja kandmisviise. Vaatluse alla on võetud rõngaspeaga, kolmnurkpeaga ja varasemad kaksikristpeaga nõelad, mille dateeringut ja tüpoloogilist arengut on varasemaga võrreldes täpsustatud. Joonised, diagrammid, fotod

  14. 22 tundi tõde ja õigust Anton Hansen Tammsaare moodi / Risto Berendson, Marika Rajamäe

    Index Scriptorium Estoniae

    Berendson, Risto, 1975-

    2008-01-01

    30. okt. kirjutati Anton Hansen Tammsaare sünniaastapäeva puhul alla lepingule, mis toob Vargamäele maratonetenduse kogu "Tõe ja õiguse" põhjal. Etendus toimub 21.-22. juunini. Kommenteerib Ülo Tonts

  15. Elu- ja mõtterännakud, minemised ja saatmised / Kaljo Põllu ; interv. Jonathan Roper, Marika Alver

    Index Scriptorium Estoniae

    Põllu, Kaljo, 1934-2010

    2007-01-01

    Kaljo Põllu oma kunstiõpingutest, loomingust, tööst Tartu Ülikooli kunstikabineti juhatajana, käikudest soomeugrilaste juurde, soome-ugri ekpeditsioonide korraldamisest kunstiinstituudis, ekspeditsioonide mõjust üliõpilaste mõtteviisile ja kunstile, rühmitusest Ydi, soomeugrilisusest eemaldumisest. Leedsi ülikooli inglise filoloogia lektor Jonathan Rops on käinud koos EKA üliõpilastega ekspeditsioonidel 1998., 1999. ja 2003. aastal

  16. Gurmaanlus ruulib / Marika Makarova ; kommenteerinud Anu Tali, René Uusmees, Tõnis Siigur, Hannes Võrno, Dimitri Demjanov

    Index Scriptorium Estoniae

    Makarova, Marika

    2010-01-01

    Tulevikutoidu konverentsil Tallinnas esinenud kuulsate kokkade Albert Adria, Fergus Hendersoni ja Claus Meyeri kokakunsti lähtekohtadest ja mõistet gurmaanlus mõtestavad lahti tuntud Eesti inimesed ja kokad

  17. Structural, electronic and magnetic properties of Mn{sub 3}N{sub 2}(0 0 1) surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Guerrero-Sánchez, J., E-mail: guerrero@ifuap.buap.mx [Department of Physics and Astronomy, Nanoscale and Quantum Phenomena Institute, Ohio University, Athens, OH 45701 (United States); Benemérita Universidad Autónoma de Puebla, Instituto de Física “Ing Luis Rivera Terrazas”, Apartado Postal J-48, Puebla 72570 (Mexico); Mandru, Andrada-Oana; Wang, Kangkang [Department of Physics and Astronomy, Nanoscale and Quantum Phenomena Institute, Ohio University, Athens, OH 45701 (United States); Takeuchi, Noboru [Department of Physics and Astronomy, Nanoscale and Quantum Phenomena Institute, Ohio University, Athens, OH 45701 (United States); Centro de Nanociencias y Nanotecnologia, Universidad Nacional Autónoma de México, Apartado Postal 14, Ensenada, Baja California, Codigo Postal 22800 (Mexico); Cocoletzi, Gregorio H. [Benemérita Universidad Autónoma de Puebla, Instituto de Física “Ing Luis Rivera Terrazas”, Apartado Postal J-48, Puebla 72570 (Mexico); Smith, Arthur R. [Department of Physics and Astronomy, Nanoscale and Quantum Phenomena Institute, Ohio University, Athens, OH 45701 (United States)

    2015-11-15

    Graphical abstract: - Abstract: Spin-polarized first-principles total energy calculations have been performed to study the structural, electronic and magnetic properties of Mn{sub 3}N{sub 2}(0 0 1) surfaces. It is found that three surface terminations are energetically stable, in agreement with previous scanning tunneling microscopy experiments that have found three different electronic contrasts in their images. It is also found that in all three cases, the topmost layer has a MnN stoichiometry. Density of states calculations show a metallic behavior for all the stable structures with the most important contribution close to the Fermi level coming from the Mn-d orbitals. Our Tersoff–Hamann scanning tunneling microscopy simulations are in good agreement with previous experimental results.

  18. 运动神经元病认知功能损害研究现状

    Institute of Scientific and Technical Information of China (English)

    王文敏; Michael J. Strong

    2004-01-01

    目前认为运动神经元病(motor neuron diseases,MND),特别是肌萎缩侧索硬化(amyotrophic lateral sclerosis,ALS)是继Alzheimer病、帕金森病之后的第三种最常见的成年发病的进展性神经变性疾病。传统上认为,MND的变性过程仅限于运动神经元,临床表现为进行性致死性肌萎缩、肌无力和肢体僵硬。据流行病学资料ALS发生率1.0—1.8/10万,

  19. Anterior cysts of the spine: a difficult differential diagnosis to amyotrophic lateral sclerosis.

    Science.gov (United States)

    Schmalbach, S; Petri, S; Götz, F; Dengler, R; Krampfl, K

    2008-11-01

    We describe three patients referred to our ALS/MND clinic with suspected diagnosis of amyotrophic lateral sclerosis (ALS). The patients were all male, middle aged, and their initial symptoms were weakness and fasciculations in upper limb muscles. Results of clinical and electrophysiological examination in all cases were in accordance with possible ALS according to the revised El Escorial criteria. Other conditions mimicking ALS appeared to be excluded by extensive technical examinations and laboratory tests. Only repeated MRI examinations revealed anterior spinal cysts several years after symptom onset. This report intends to highlight this rare and difficult differential diagnosis of ALS and underlines the value of the revised El Escorial criteria in conjunction with electrophysiology to asses the certainty of the diagnosis ALS.

  20. Assessment of performance validity in the Stroop Color and Word Test in mild traumatic brain injury patients: a criterion-groups validation design.

    Science.gov (United States)

    Guise, Brian J; Thompson, Matthew D; Greve, Kevin W; Bianchini, Kevin J; West, Laura

    2014-03-01

    The current study assessed performance validity on the Stroop Color and Word Test (Stroop) in mild traumatic brain injury (TBI) using criterion-groups validation. The sample consisted of 77 patients with a reported history of mild TBI. Data from 42 moderate-severe TBI and 75 non-head-injured patients with other clinical diagnoses were also examined. TBI patients were categorized on the basis of Slick, Sherman, and Iverson (1999) criteria for malingered neurocognitive dysfunction (MND). Classification accuracy is reported for three indicators (Word, Color, and Color-Word residual raw scores) from the Stroop across a range of injury severities. With false-positive rates set at approximately 5%, sensitivity was as high as 29%. The clinical implications of these findings are discussed. © 2012 The British Psychological Society.