WorldWideScience

Sample records for sema katrin gross-paju

  1. Exercise KATRINE

    International Nuclear Information System (INIS)

    Clahane, Darren; Burgoyne, William

    1995-01-01

    Based on a hypothetical incident at the Scottish Nuclear Ltd Torness AGR nuclear power station, Exercise KATRINE was the 1994 national civil nuclear exercise and the biggest simulation of a nuclear accident to take place in Britain last year. The exercise, held on 17 and 18 November, was based on a series of postulated faults which resulted in an uncontrolled release of radioactivity. It commenced at 07.00 on Thursday and continued for about 33 hours, until around 15.30 on Friday. Activity focused on the Torness Off-site Centre (TOSC), in Cockenzie near Edinburgh, and the brand new Torness Media Briefing Centre (TMBC) located nearby. (author)

  2. Katrin Pajuste / Jane Frey

    Index Scriptorium Estoniae

    Frey, Jane, 1950-

    2005-01-01

    24. septembril 2004. a. kaitses Katrin Pajuste Tartu Ülikoolis väitekirja teemal "Õhusaasteainete sadenemine ja transformeerumine okaspuumetsades: Eesti riiklike seireandmete põhjal" ("Deposition and transformation of air pollutants in coniferous forests: a study based on Estonian monitoring data")

  3. Ions in the KATRIN experiment

    Energy Technology Data Exchange (ETDEWEB)

    Glueck, Ferenc [KIT, Campus Nord (Germany); Collaboration: KATRIN-Collaboration

    2016-07-01

    The aim of the KATRIN experiment is to determine the absolute neutrino mass scale in a model independent way, by measuring the electron energy spectrum shape near the endpoint of tritium beta decay. Beta decays and ionizations produce about 2 . 10{sup 12} s{sup -1} tritium ion rate in the KATRIN source. About 10 % and 1 % of that rate is the expected flux of positive tritium ions and T{sup -} ions leaving the source in detector direction. The positive tritium ions are not affected by the pumping system, and, when unhindered, they would cause an extremely large background and tritium contamination in the spectrometers. They will be blocked in the transport system by positive potential electrodes and will be removed from the flux tube by dipole electrodes. The ion composition and the ion blocking and removal efficiency will be tested by an FT-ICR trap, a Faraday cup and the KATRIN pre- and main spectrometers and FPD, using both a photoelectron induced deuterium plasma and the tritium beta decay plasma.

  4. Katrin Kuldma - obladatelnitsa "Zolotoi iglõ" / Olga Grigorjeva

    Index Scriptorium Estoniae

    Grigorjeva, Olga, 1983-

    2007-01-01

    FIBIT-i moepäevadest ja Kuldnõela galast. Kuldnõela nominendid olid Reet Aus, Katrin Kuldma, Marika Siska ja Tiiu Roosma. 2006. a. moepreemia "Kuldnõel" sai kollektsiooni "Chocolat" eest Katrin Kuldma

  5. Analysis of KATRIN data using Bayesian inference

    DEFF Research Database (Denmark)

    Riis, Anna Sejersen; Hannestad, Steen; Weinheimer, Christian

    2011-01-01

    The KATRIN (KArlsruhe TRItium Neutrino) experiment will be analyzing the tritium beta-spectrum to determine the mass of the neutrino with a sensitivity of 0.2 eV (90% C.L.). This approach to a measurement of the absolute value of the neutrino mass relies only on the principle of energy conservation...

  6. Anti-SEMA3A Antibody: A Novel Therapeutic Agent to Suppress GBM Tumor Growth.

    Science.gov (United States)

    Lee, Jaehyun; Shin, Yong Jae; Lee, Kyoungmin; Cho, Hee Jin; Sa, Jason K; Lee, Sang-Yun; Kim, Seok-Hyung; Lee, Jeongwu; Yoon, Yeup; Nam, Do-Hyun

    2017-11-10

    Glioblastoma (GBM) is classified as one of the most aggressive and lethal brain tumor. Great strides have been made in understanding the genomic and molecular underpinnings of GBM, which translated into development of new therapeutic approaches to combat such deadly disease. However, there are only few therapeutic agents that can effectively inhibit GBM invasion in a clinical framework. In an effort to address such challenges, we have generated anti-SEMA3A monoclonal antibody as a potential therapeutic antibody against GBM progression. We employed public glioma datasets, Repository of Molecular Brain Neoplasia Data and The Cancer Genome Atlas, to analyze SEMA3A mRNA expression in human GBM specimens. We also evaluated for protein expression level of SEMA3A via tissue microarray (TMA) analysis. Cell migration and proliferation kinetics were assessed in various GBM patient-derived cells (PDCs) and U87-MG cell-line for SEMA3A antibody efficacy. GBM patient-derived xenograft (PDX) models were generated to evaluate tumor inhibitory effect of anti-SEMA3A antibody in vivo. By combining bioinformatics and TMA analysis, we discovered that SEMA3A is highly expressed in human GBM specimens compared to non-neoplastic tissues. We developed three different anti-SEMA3A antibodies, in fully human IgG form, through screening phage-displayed synthetic antibody library using a classical panning method. Neutralization of SEMA3A significantly reduced migration and proliferation capabilities of PDCs and U87-MG cell-line in vitro. In PDX models, treatment with anti-SEMA3A antibody exhibited notable tumor inhibitory effect through down-regulation of cellular proliferative kinetics and tumor-associated macrophages recruitment. In present study, we demonstrated tumor inhibitory effect of SEMA3A antibody in GBM progression and present its potential relevance as a therapeutic agent in a clinical framework.

  7. A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib.

    Science.gov (United States)

    Sun, Tianliang; Yang, Lida; Kaur, Harmandeep; Pestel, Jenny; Looso, Mario; Nolte, Hendrik; Krasel, Cornelius; Heil, Daniel; Krishnan, Ramesh K; Santoni, Marie-Josée; Borg, Jean-Paul; Bünemann, Moritz; Offermanns, Stefan; Swiercz, Jakub M; Worzfeld, Thomas

    2017-01-02

    Semaphorins comprise a large family of ligands that regulate key cellular functions through their receptors, plexins. In this study, we show that the transmembrane semaphorin 4A (Sema4A) can also function as a receptor, rather than a ligand, and transduce signals triggered by the binding of Plexin-B1 through reverse signaling. Functionally, reverse Sema4A signaling regulates the migration of various cancer cells as well as dendritic cells. By combining mass spectrometry analysis with small interfering RNA screening, we identify the polarity protein Scrib as a downstream effector of Sema4A. We further show that binding of Plexin-B1 to Sema4A promotes the interaction of Sema4A with Scrib, thereby removing Scrib from its complex with the Rac/Cdc42 exchange factor βPIX and decreasing the activity of the small guanosine triphosphatase Rac1 and Cdc42. Our data unravel a role for Plexin-B1 as a ligand and Sema4A as a receptor and characterize a reverse signaling pathway downstream of Sema4A, which controls cell migration. © 2017 Sun et al.

  8. Semaphorin SEMA3F and VEGF Have Opposing Effects on Cell Attachment and Spreading

    Directory of Open Access Journals (Sweden)

    Patrick Nasarre

    2003-01-01

    Full Text Available SEMA3F, isolated from a 3p21.3 deletion, has antitumor activity in transfected cells, and protein expression correlates with tumor stage and histology. In primary tumors, SEMA3F and VEGF surface staining is inversely correlated. Coupled with SEMA3F at the leading edge of motile cells, we previously suggested that both proteins competitively regulate cell motility and adhesion. We have investigated this using the breast cancer cell line, MCF7. SEMA3F inhibited cell attachment and spreading as evidenced by loss of lamellipodia extensions, membrane ruffling, and cell-cell contacts, with cells eventually rounding-up and detaching. In contrast, VEGF had opposite effects. Although SEMA3F binds NRP2 with 10-fold greater affinity than NRP1, the effects in MCF7 were mediated by NRP1. This was determined by receptor expression and blocking of anti-NRP1 antibodies. Similar effects, but through NRP2, were observed in the C100 breast cancer cell line. Although we were unable to demonstrate changes in total GTPbound Rac1 or RhoA, we did observe changes in the localization of Rac1-GFP using time lapse microscopy. Following SEMA3F, Rac1 moved to the base of lamellipodia and — with their collapse — to the membrane. These results support the concept that SEMA3F and VEGF have antagonistic actions affecting motility in primary tumor cell.

  9. Collection of $^{83}$Rb at low implantation energy for KATRIN

    CERN Multimedia

    Zboril, M

    KATRIN, the KArlsruhe TRItium Neutrino experiment aims to measure the neutrino mass by spectroscopy of the tritium $\\beta$-decay at the endpoint by means of Magnetic Adiabatic Collimation combined with an Electrostatic filter (MAC-E filter). To monitor the HV-system of the KATRIN-setup, we would need one or two $^{83}$Rb sources roughly every half a year.

  10. Lifestyle / Tuuli Köller, Katrin Koov

    Index Scriptorium Estoniae

    Köller, Tuuli

    2005-01-01

    13.-17. X 2004 Jõesuus Põhjamaade Ehitusakadeemia V Sügispäevade raames toimunud rahvusvahelisest workshop'ist "Lifestyle", mille eestipoolne põhikorraldaja oli AB Sadakond, kaasa aitas Kavakava, toetas Eesti Kunstiakadeemia. Osalesid arhitektid, kunstnikud, arhitektuuri- ja kunstiüliõpilased Soomest, Rootsist, Saksamaalt ja Itaaliast. Keskenduti kolhoosiarhitektuurile. Katrin Koovi, Siiri Vallneri ja Kaire Nõmme, Rene Valneri ja Kalle Komissarovi jt. töödest

  11. Are Sema5a mutant mice a good model of autism? A behavioral analysis of sensory systems, emotionality and cognition

    Science.gov (United States)

    Gunn, Rhian K.; Huentelman, Matthew J.; Brown, Richard E.

    2011-01-01

    Semaphorin 5A (Sema5A) expression is reduced in the brain of individuals with autism, thus mice with reduced Sema5A levels may serve as a model of this neurodevelopmental disorder. We tested male and female Sema5a knockout mice (B6.129P2SEMA5A/J) and C57BL/6J controls for emotionality, visual ability, prepulse inhibition, motor learning and cognition. Overall, there were only two genotype differences in emotionality: Sema5a mutant mice had more stretch-attend postures in the elevated plus-maze and more defecations in the open field. All mice could see, but Sema5a mice had better visual ability than C57BL/6J mice. There were no genotype differences in sensory-motor gating. Sema5a mice showed higher levels of activity in the elevated plus-maze and light/dark transition box, and there were sex by genotype differences in the Rotarod, suggesting a sex difference in balance and coordination differentially affected by Sema5a. There were no genotype effects on cognition: Sema5a mice did not differ from C57BL/6J in the Morris water maze, set-shifting or cued and contextual fear conditioning. In the social recognition test, all mice preferred social stimuli, but there was no preference for social novelty, thus the Sema5A mice do not have a deficit in social behavior. Overall, there were a number of sex differences, with females showing greater activity and males performing better in tests of spatial learning and memory, but no deficits in the behavior of Sema5A mice. We conclude that the Sema5a mice do not meet the behavioral criteria for a mouse model of autism. PMID:21777623

  12. Kalalaev Katrin jääbki kadunuks / Kadi Laid

    Index Scriptorium Estoniae

    Laid, Kadi, 1976-

    2003-01-01

    Politsei lõpetab kalalaeva Katrin huku uurimise, kuna vaatamata korduvatele sukeldumistele, ei ole suudetud laevavrakki leida. Laeva kindlustanud Bico-Leks Kindlustuse AS-i järglane ERGO Kindlustus peab omanikule kindlustusraha välja maksma

  13. SEMA6D Expression and Patient Survival in Breast Invasive Carcinoma

    Directory of Open Access Journals (Sweden)

    Dongquan Chen

    2015-01-01

    Full Text Available Breast cancer (BC is the second most common cancer diagnosed in American women and is also the second leading cause of cancer death in women. Research has focused heavily on BC metastasis. Multiple signaling pathways have been implicated in regulating BC metastasis. Our knowledge of regulation of BC metastasis is, however, far from complete. Identification of new factors during metastasis is an essential step towards future therapy. Our labs have focused on Semaphorin 6D (SEMA6D, which was implicated in immune responses, heart development, and neurogenesis. It will be interesting to know SEMA6D-related genomic expression profile and its implications in clinical outcome. In this study, we examined the public datasets of breast invasive carcinoma from The Cancer Genome Atlas (TCGA. We analyzed the expression of SEMA6D along with its related genes, their functions, pathways, and potential as copredictors for BC patients’ survival. We found 6-gene expression profile that can be used as such predictors. Our study provides evidences for the first time that breast invasive carcinoma may contain a subtype based on SEMA6D expression. The expression of SEMA6D gene may play an important role in promoting patient survival, especially among triple negative breast cancer patients.

  14. Sema3C Promotes the Survival and Tumorigenicity of Glioma Stem Cells through Rac1 Activation

    Directory of Open Access Journals (Sweden)

    Jianghong Man

    2014-12-01

    Full Text Available Summary: Different cancer cell compartments often communicate through soluble factors to facilitate tumor growth. Glioma stem cells (GSCs are a subset of tumor cells that resist standard therapy to contribute to disease progression. How GSCs employ a distinct secretory program to communicate with and nurture each other over the nonstem tumor cell (NSTC population is not well defined. Here, we show that GSCs preferentially secrete Sema3C and coordinately express PlexinA2/D1 receptors to activate Rac1/nuclear factor (NF-κB signaling in an autocrine/paracrine loop to promote their own survival. Importantly, Sema3C is not expressed in neural progenitor cells (NPCs or NSTCs. Disruption of Sema3C induced apoptosis of GSCs, but not NPCs or NSTCs, and suppressed tumor growth in orthotopic models of glioblastoma. Introduction of activated Rac1 rescued the Sema3C knockdown phenotype in vivo. Our study supports the targeting of Sema3C to break this GSC-specific autocrine/paracrine loop in order to improve glioblastoma treatment, potentially with a high therapeutic index. : Glioma stem cells (GSCs have a high capacity for self-renewal, invasion, and survival. How they communicate with each other to survive and maintain their identity is not clear. Man et al. now show that GSCs have co-opted a neurodevelopmental program to activate Rac1 to promote defining features of GSCs.

  15. The self-consistent effective medium approximation (SEMA): New tricks from an old dog

    International Nuclear Information System (INIS)

    Bergman, David J.

    2007-01-01

    The fact that the self-consistent effective medium approximation (SEMA) leads to incorrect values for the percolation threshold, as well as for the critical exponents which characterize that threshold, has led to a decline in using that approximation. In this article I argue that SEMA has the unique capability, which is lacking in other approximation schemes for macroscopic response of composite media, of leading to the discovery or prediction of new critical points. This is due to the fact that SEMA can often lead to explicit equations for the macroscopic response of a composite medium, even when that medium has a rather complicated character. In such cases, the SEMA equations are usually coupled and nonlinear, often even transcendental in character. Thus there is no question of finding exact solutions. Nevertheless, a useful ansatz, leading to a closed form asymptotic solution, can often be made. In this way, singularities in the macroscopic response can be identified from a theoretical or mathematical treatment of the physical problem. This is demonstrated for two problems of magneto-transport in a composite medium, where the SEMA equations are solved using asymptotic analysis, leading to new types of critical points and critical behavior

  16. Inactivation of the Sema5a gene results in embryonic lethality and defective remodeling of the cranial vascular system

    NARCIS (Netherlands)

    Fiore, Roberto; Rahim, Belquis; Christoffels, Vincent M.; Moorman, Antoon F. M.; Püschel, Andreas W.

    2005-01-01

    The semaphorins are a large family of proteins involved in the patterning of both the vascular and the nervous systems. In order to analyze the function of the membrane-bound semaphorin 5A (Sema5A), we generated mice homozygous for a null mutation in the Sema5a gene. Homozygous null mutants die

  17. The Role of Semaphorin 3B (SEMA3B) in the Pathogenesis of Breast Cancer

    Science.gov (United States)

    2006-04-01

    apoptotic and anti-proliferative effect on cancer lines it is in part by the inhibition of Akt pathway. In conclusion, we hypothesize that VEGF165...autocrine activity and by inhibiting the Akt pathway. 15. SUBJECT TERMS tumor suppressor gene, breast cancer and apoptosis 16. SECURITY...TGFβ TGFR2 Smad4 M D A M B A 54 9 H 12 99 H el a H 46 0 M C F7 ZR -7 5 H 15 7 2 31 GAPDH TGFR1 B. C 2H 24H 48H 72H SEMA3B SEMA3B

  18. Tritium source-related systematic uncertainties of the KATRIN experiment

    Energy Technology Data Exchange (ETDEWEB)

    Seitz-Moskaliuk, Hendrik [Karlsruher Institut fuer Technologie, Institut fuer experimentelle Kernphysik, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Collaboration: KATRIN-Collaboration

    2016-07-01

    KATRIN will perform a direct, kinematics-based measurement of the neutrino mass with a sensitivity of 200 meV (90 % C. L.) reached after 3 years of measurement time. The neutrino mass is obtained by determining the shape of the spectrum of tritium β decay electrons close to the endpoint of 18.6 keV with a spectrometer of MAC-E filter type. To achieve the planned sensitivity, the systematic measurement uncertainties have to be carefully controlled and evaluated. Main sources of systematics are the MAC-E filter on the one hand and the source and transport section (STS) on the other hand. Most of the operational parameters of KATRIN have to be stable at or even below the per mille level and have to meet further strict requirements. This talk reviews the KATRIN systematics with a special focus on the STS. Early commissioning measurements to determine the main systematics are introduced.

  19. DRG axon elongation and growth cone collapse rate induced by Sema3A are differently dependent on NGF concentration.

    Science.gov (United States)

    Kaselis, Andrius; Treinys, Rimantas; Vosyliūtė, Rūta; Šatkauskas, Saulius

    2014-03-01

    Regeneration of embryonic and adult dorsal root ganglion (DRG) sensory axons is highly impeded when they encounter neuronal growth cone-collapsing factor semaphorin3A (Sema3A). On the other hand, increasing evidence shows that DRG axon's regeneration can be stimulated by nerve growth factor (NGF). In this study, we aimed to evaluate whether increased NGF concentrations can counterweight Sema3A-induced inhibitory responses in 15-day-old mouse embryo (E15) DRG axons. The DRG explants were grown in Neurobasal-based medium with different NGF concentrations ranging from 0 to 100 ng/mL and then treated with Sema3A at constant 10 ng/mL concentration. To evaluate interplay between NGF and Sema3A number of DRG axons, axon outgrowth distance and collapse rate were measured. We found that the increased NGF concentrations abolish Sema3A-induced inhibitory effect on axon outgrowth, while they have no effect on Sema3A-induced collapse rate.

  20. Kunstnikud hindasid Eesti telekanalite uudistesaateid / Tarmo Luisk, Dan Mikkin, Katrin Kuldma

    Index Scriptorium Estoniae

    Luisk, Tarmo, 1970-

    2011-01-01

    Disainer Tarmo Luisk, graafik Dan Mikkin ja moekunstnik Katrin Kuldma hindasid Eesti telekanalite uudistesaateid "Aktuaalne kaamera" (ETV), "Reporter" (Kanal 2) ja "Seitsmesed uudised"(TV 3) esteetilisest vaatepunktist

  1. Tundmatud kohad ja asjade loomus / Katrine Gram Sloth, Johna Hansen ; intervjueerinud Laura Põld

    Index Scriptorium Estoniae

    Gram Sloth, Katrine, 1983-

    2016-01-01

    Taani kunstnik Katrine Gram Sloth ja Rootsi arhitekt Johna Hansen räägivad oma lapsepõlvest, kunstnikuteest, loomingust. Johna Hanseni jaapanipärasest einelaua installatsioonist "Laud" (2015-2016), Katrine Gram Slothi Islandil loodud teosest "Vista Revisited" (2015)

  2. SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome.

    Science.gov (United States)

    Hanchate, Naresh Kumar; Giacobini, Paolo; Lhuillier, Pierre; Parkash, Jyoti; Espy, Cécile; Fouveaut, Corinne; Leroy, Chrystel; Baron, Stéphanie; Campagne, Céline; Vanacker, Charlotte; Collier, Francis; Cruaud, Corinne; Meyer, Vincent; García-Piñero, Alfons; Dewailly, Didier; Cortet-Rudelli, Christine; Gersak, Ksenija; Metz, Chantal; Chabrier, Gérard; Pugeat, Michel; Young, Jacques; Hardelin, Jean-Pierre; Prevot, Vincent; Dodé, Catherine

    2012-08-01

    Kallmann syndrome (KS) associates congenital hypogonadism due to gonadotropin-releasing hormone (GnRH) deficiency and anosmia. The genetics of KS involves various modes of transmission, including oligogenic inheritance. Here, we report that Nrp1(sema/sema) mutant mice that lack a functional semaphorin-binding domain in neuropilin-1, an obligatory coreceptor of semaphorin-3A, have a KS-like phenotype. Pathohistological analysis of these mice indeed showed abnormal development of the peripheral olfactory system and defective embryonic migration of the neuroendocrine GnRH cells to the basal forebrain, which results in increased mortality of newborn mice and reduced fertility in adults. We thus screened 386 KS patients for the presence of mutations in SEMA3A (by Sanger sequencing of all 17 coding exons and flanking splice sites) and identified nonsynonymous mutations in 24 patients, specifically, a frameshifting small deletion (D538fsX31) and seven different missense mutations (R66W, N153S, I400V, V435I, T688A, R730Q, R733H). All the mutations were found in heterozygous state. Seven mutations resulted in impaired secretion of semaphorin-3A by transfected COS-7 cells (D538fsX31, R66W, V435I) or reduced signaling activity of the secreted protein in the GN11 cell line derived from embryonic GnRH cells (N153S, I400V, T688A, R733H), which strongly suggests that these mutations have a pathogenic effect. Notably, mutations in other KS genes had already been identified, in heterozygous state, in five of these patients. Our findings indicate that semaphorin-3A signaling insufficiency contributes to the pathogenesis of KS and further substantiate the oligogenic pattern of inheritance in this developmental disorder.

  3. SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome.

    Directory of Open Access Journals (Sweden)

    Naresh Kumar Hanchate

    2012-08-01

    Full Text Available Kallmann syndrome (KS associates congenital hypogonadism due to gonadotropin-releasing hormone (GnRH deficiency and anosmia. The genetics of KS involves various modes of transmission, including oligogenic inheritance. Here, we report that Nrp1(sema/sema mutant mice that lack a functional semaphorin-binding domain in neuropilin-1, an obligatory coreceptor of semaphorin-3A, have a KS-like phenotype. Pathohistological analysis of these mice indeed showed abnormal development of the peripheral olfactory system and defective embryonic migration of the neuroendocrine GnRH cells to the basal forebrain, which results in increased mortality of newborn mice and reduced fertility in adults. We thus screened 386 KS patients for the presence of mutations in SEMA3A (by Sanger sequencing of all 17 coding exons and flanking splice sites and identified nonsynonymous mutations in 24 patients, specifically, a frameshifting small deletion (D538fsX31 and seven different missense mutations (R66W, N153S, I400V, V435I, T688A, R730Q, R733H. All the mutations were found in heterozygous state. Seven mutations resulted in impaired secretion of semaphorin-3A by transfected COS-7 cells (D538fsX31, R66W, V435I or reduced signaling activity of the secreted protein in the GN11 cell line derived from embryonic GnRH cells (N153S, I400V, T688A, R733H, which strongly suggests that these mutations have a pathogenic effect. Notably, mutations in other KS genes had already been identified, in heterozygous state, in five of these patients. Our findings indicate that semaphorin-3A signaling insufficiency contributes to the pathogenesis of KS and further substantiate the oligogenic pattern of inheritance in this developmental disorder.

  4. Vonis Mati Bandar Dan Pengedar Narkoba Antara Putusan Mk Dan Sema (Perspektif Hukum Pidana Islam)

    OpenAIRE

    Irfan, M Nurul

    2014-01-01

    : The Dead Penalty for the Drug Dealers in the Constitutional Court and the Sema (an Islamic Criminal Law Perspective). The death sentence set by the Supreme Court for the agents and drug dealers has attracted attention of criminal law experts. Constitutional Court Decision No. 34 / PUU-X /2013 which annuls Article 268 paragraph (3) Criminal Procedure Code-stating that the submission PK (judicial review) can only be done once- has open a chance that the PK can be submitted more than once. Thi...

  5. The role of Sema3–Npn-1 signaling during diaphragm innervation and muscle development

    Science.gov (United States)

    Huettl, Rosa-Eva; Hanuschick, Philipp; Amend, Anna-Lena; Alberton, Paolo; Aszodi, Attila; Huber, Andrea B.

    2016-01-01

    ABSTRACT Correct innervation of the main respiratory muscle in mammals, namely the thoracic diaphragm, is a crucial pre-requisite for the functionality of this muscle and the viability of the entire organism. Systemic impairment of Sema3A–Npn-1 (Npn-1 is also known as NRP1) signaling causes excessive branching of phrenic nerves in the diaphragm and into the central tendon region, where the majority of misguided axons innervate ectopic musculature. To elucidate whether these ectopic muscles are a result of misguidance of myoblast precursors due to the loss of Sema3A–Npn-1 signaling, we conditionally ablated Npn-1 in somatic motor neurons, which led to a similar phenotype of phrenic nerve defasciculation and, intriguingly, also formation of innervated ectopic muscles. We therefore hypothesize that ectopic myocyte fusion is caused by additional factors released by misprojecting growth cones. Slit2 and its Robo receptors are expressed by phrenic motor axons and migrating myoblasts, respectively, during innervation of the diaphragm. In vitro analyses revealed a chemoattractant effect of Slit2 on primary diaphragm myoblasts. Thus, we postulate that factors released by motor neuron growth cones have an influence on the migration properties of myoblasts during establishment of the diaphragm. PMID:27466379

  6. Gaseous 83mKr generator for KATRIN

    Science.gov (United States)

    Sentkerestiová, J.; Dragoun, O.; Lebeda, O.; Ryšavý, M.; Sturm, M.; Vénos, D.

    2018-04-01

    Monoenergetic conversion electrons from the 83mKrKr isomeric state have been proven to be useful in the calibration of several tritium neutrino mass and dark matter experiments. In this paper the design and characteristics of the gaseous 83mKrKr generator, including the 83Rb/83mKrKr source behavior in tritium, for the KATRIN experiment are presented. Using Si(Li) and silicon drift detectors (SDD) detectors, the half-life of the 83mKrKr isomeric state was measured to be 1.8620 ± 0.0019 h.

  7. mTOR Complex Signaling through the SEMA4A-Plexin B2 Axis Is Required for Optimal Activation and Differentiation of CD8+ T Cells.

    Science.gov (United States)

    Ito, Daisuke; Nojima, Satoshi; Nishide, Masayuki; Okuno, Tatsusada; Takamatsu, Hyota; Kang, Sujin; Kimura, Tetsuya; Yoshida, Yuji; Morimoto, Keiko; Maeda, Yohei; Hosokawa, Takashi; Toyofuku, Toshihiko; Ohshima, Jun; Kamimura, Daisuke; Yamamoto, Masahiro; Murakami, Masaaki; Morii, Eiichi; Rakugi, Hiromi; Isaka, Yoshitaka; Kumanogoh, Atsushi

    2015-08-01

    Mammalian target of rapamycin (mTOR) plays crucial roles in activation and differentiation of diverse types of immune cells. Although several lines of evidence have demonstrated the importance of mTOR-mediated signals in CD4(+) T cell responses, the involvement of mTOR in CD8(+) T cell responses is not fully understood. In this study, we show that a class IV semaphorin, SEMA4A, regulates CD8(+) T cell activation and differentiation through activation of mTOR complex (mTORC) 1. SEMA4A(-/-) CD8(+) T cells exhibited impairments in production of IFN-γ and TNF-α and induction of the effector molecules granzyme B, perforin, and FAS-L. Upon infection with OVA-expressing Listeria monocytogenes, pathogen-specific effector CD8(+) T cell responses were significantly impaired in SEMA4A(-/-) mice. Furthermore, SEMA4A(-/-) CD8(+) T cells exhibited reduced mTORC1 activity and elevated mTORC2 activity, suggesting that SEMA4A is required for optimal activation of mTORC1 in CD8(+) T cells. IFN-γ production and mTORC1 activity in SEMA4A(-/-) CD8(+) T cells were restored by administration of recombinant Sema4A protein. In addition, we show that plexin B2 is a functional receptor of SEMA4A in CD8(+) T cells. Collectively, these results not only demonstrate the role of SEMA4A in CD8(+) T cells, but also reveal a novel link between a semaphorin and mTOR signaling. Copyright © 2015 by The American Association of Immunologists, Inc.

  8. Neli Peret Hispaanias, tekstiilikunstnikest rääkimata / Katrin Pere

    Index Scriptorium Estoniae

    Pere, Katrin, 1952-

    1998-01-01

    9. - 12. märtsini Barcelonas ja Madridis toimunud European Textile Networki aastakonverentsist. Eestist osalesid : Lylian Meister, Lea Pruuli, Aet Ollisaar-Kalamees, Katrin Pere, Merike Männi, Aune Taamal, Anne Tootma, Signe Kivi, Peeter Pere

  9. Väike pahe või suur kirg? / Katrin Pauts

    Index Scriptorium Estoniae

    Pauts, Katrin, 1977-

    2006-01-01

    Veinijoomisest, sigari suitsetamisest ning kaartide tagumisest räägivad sigarisalongi La Casa del Habano perenaine Angela Leima, Tartu Veiniklubi liige Katrin Pärgmäe ja bridzhiklubi president Marion Ründal

  10. Kuu plaat : Lauri Saatpalu ja Katrin Mandel "Sa oled hea". Plaadid kauplusest Lasering

    Index Scriptorium Estoniae

    2005-01-01

    Heliplaatidest: Lauri Saatpalu ja Katrin Mandel "Sa oled hea", Goldfrapp "Supernature", Ultima Thule "Ingel ja suli", Sigur Ros "Takk...", Franz Ferdinand "You Could Have It So Much Better", Ans.Andur "Tuled peale"

  11. Pärnu Kontserdimaja : Pärnu, Aida tn. 4 / Katrin Koov

    Index Scriptorium Estoniae

    Koov, Katrin, 1973-

    2003-01-01

    Projekteerija: COO Arhitektid. Arhitektid-sisekujundajad Hanno Grossschmidt, Kaire Nõmm, Katrin Koov. Konstruktor: Inseneribüroo Pike OÜ. Projekt: jaanuar 2002, valmis: november 2002. I ja II korruse plaan, 2 välis- ja 3 sisevaadet

  12. Twilio Eesti büroo = Offices of Twilio Estonia / Katrin Kaevats ; kommenteerinud Ann Koljang

    Index Scriptorium Estoniae

    Kaevats, Katrin, 1980-

    2016-01-01

    Rahvusvahelise ettevõtte Twilio Eesti büroo Tallinnas, Veerenni tn. 24. Sisekujunduse autorid Katrin Kaevats, Jaan Port, Markus Nimik, Neeme Tiimus, Anna Nikland. Büroohoone projekteerisid PIN Arhitektid

  13. Sarnaneme ja eristume vormirõiva abiga / Britt Samoson ; kommenteerinud Katrin Kuldma

    Index Scriptorium Estoniae

    Samoson, Britt, 1982-

    2010-01-01

    Jaana Varkki ja Erkki Engso disainitud EXPO Shanghai 2010 maailmanäituse Eesti Paviljoni tiimitöötajate vormirõivastest. Rahvusooper Estonia ning Nokia kontserdimaja teenindajate rõivaid tutvustab nende looja Katrin Kuldma

  14. Solid electron sources for the energy scale monitoring in the KATRIN experiment

    CERN Document Server

    Zbořil, Miroslav; Vénos, D

    The KArlsruhe TRItium Neutrino (KATRIN) experiment represents a next-generation tritium $\\beta$-decay experiment designed to perform a high precision direct measurement of the electron anti-neutrino mass m($\

  15. Missugused on teie kogemused väikeklassidega? / Villu Mengel, Ana Kontor, Katrin Betlem, Riina Kink

    Index Scriptorium Estoniae

    2013-01-01

    Küsimusele vastasid Sikupilli keskkooli direktor Villu Mengel, Tartu hariduse tugiteenuste keskuse eripedagoog Ana Kontor, Tabasalu ühisgümnaasiumi õppejuht-sotsiaalpedagoog Katrin Betlem, Keila kooli põhikooli õppejuht Riina Kink

  16. Investigation of background processes in the KATRIN main spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, Axel [Karlsruhe Institute of Technology (KIT), Institut fuer Kernphysik (IKP) (Germany); Collaboration: KATRIN-Collaboration

    2016-07-01

    The KArlsruhe TRItium Neutrino experiment aims to probe the mass of the electron antineutrino in a model-independent way with an unsurpassed sensitivity of m{sub ν}=200 meV/c{sup 2} (90% C.L.). In order to determine the neutrino mass, the energy spectrum of electrons from the tritium β-decay is analyzed by a high-resolution electrostatic spectrometer which is based on the MAC-E filter principle. To keep the influence of the spectrometer background on the neutrino mass sensitivity small, KATRIN aims for a background level of 0.01 cps. For the investigation of different background components such as cosmic muons, external gamma radiation and the radioactive decay of isotopes in the volume of the spectrometer or on its surface, a series of dedicated measurements were performed with a combined system of main spectrometer and detector. This talk presents the results of measurements focusing on the secondary electron production at the inner surface of the spectrometer and compare them with electro-magnetic electron tracking simulations performed with the KATRIN developed simulation software KASSIOPEIA.

  17. Monitoring of the energy scale in the KATRIN neutrino experiment

    CERN Document Server

    AUTHOR|(CDS)2083282

    The question of the absolute mass scale of neutrinos is of particular interest for particle physics, astrophysics, and cosmology. The KATRIN experiment (KArlsruhe TRItium Neutrino experiment) aims to address the effective electron antineutrino mass from the shape of the tritium $\\beta$-spectrum with an unprecedented sensitivity of 0.2 eV/c$^2$. One of the major systematic effects concerns the experimental energy scale, which has to be stable at the level of only a few parts in a million. For its calibration and monitoring the monoenergetic electrons emitted in the internal conversion of $\\gamma$-transition of the metastable isotope $^{83\\mathrm{m}}$Kr will be extensively applied. The aim of this thesis is to address the problem of KATRIN energy scale distortions and its monitoring in detail. The source of electrons based on $^{83\\mathrm{m}}$Kr embedded in a solid as well as the source based on gaseous $^{83\\mathrm{m}}$Kr are studied. Based on the experimental results an approach for the continuous stability m...

  18. Forecasting neutrino masses from combining KATRIN and the CMB observations: Frequentist and Bayesian analyses

    Science.gov (United States)

    Host, Ole; Lahav, Ofer; Abdalla, Filipe B.; Eitel, Klaus

    2007-12-01

    We present a showcase for deriving bounds on the neutrino masses from laboratory experiments and cosmological observations. We compare the frequentist and Bayesian bounds on the effective electron neutrino mass mβ which the KATRIN neutrino mass experiment is expected to obtain, using both an analytical likelihood function and Monte Carlo simulations of KATRIN. Assuming a uniform prior in mβ, we find that a null result yields an upper bound of about 0.17 eV at 90% confidence in the Bayesian analysis, to be compared with the frequentist KATRIN reference value of 0.20 eV. This is a significant difference when judged relative to the systematic and statistical uncertainties of the experiment. On the other hand, an input mβ=0.35eV, which is the KATRIN 5σ detection threshold, would be detected at virtually the same level. Finally, we combine the simulated KATRIN results with cosmological data in the form of present (post-WMAP) and future (simulated Planck) observations. If an input of mβ=0.2eV is assumed in our simulations, KATRIN alone excludes a zero neutrino mass at 2.2σ. Adding Planck data increases the probability of detection to a median 2.7σ. The analysis highlights the importance of combining cosmological and laboratory data on an equal footing.

  19. Forecasting neutrino masses from combining KATRIN and the CMB observations: Frequentist and Bayesian analyses

    International Nuclear Information System (INIS)

    Host, Ole; Lahav, Ofer; Abdalla, Filipe B.; Eitel, Klaus

    2007-01-01

    We present a showcase for deriving bounds on the neutrino masses from laboratory experiments and cosmological observations. We compare the frequentist and Bayesian bounds on the effective electron neutrino mass m β which the KATRIN neutrino mass experiment is expected to obtain, using both an analytical likelihood function and Monte Carlo simulations of KATRIN. Assuming a uniform prior in m β , we find that a null result yields an upper bound of about 0.17 eV at 90% confidence in the Bayesian analysis, to be compared with the frequentist KATRIN reference value of 0.20 eV. This is a significant difference when judged relative to the systematic and statistical uncertainties of the experiment. On the other hand, an input m β =0.35 eV, which is the KATRIN 5σ detection threshold, would be detected at virtually the same level. Finally, we combine the simulated KATRIN results with cosmological data in the form of present (post-WMAP) and future (simulated Planck) observations. If an input of m β =0.2 eV is assumed in our simulations, KATRIN alone excludes a zero neutrino mass at 2.2σ. Adding Planck data increases the probability of detection to a median 2.7σ. The analysis highlights the importance of combining cosmological and laboratory data on an equal footing

  20. The SEMA5A gene is associated with hippocampal volume, and their interaction is associated with performance on Raven's Progressive Matrices.

    Science.gov (United States)

    Zhu, Bi; Chen, Chuansheng; Xue, Gui; Moyzis, Robert K; Dong, Qi; Chen, Chunhui; Li, Jin; He, Qinghua; Lei, Xuemei; Wang, Yunxin; Lin, Chongde

    2014-03-01

    The Allen Brain Atlas shows that the semaphorin 5A (SEMA5A) gene, which encodes an important protein for neurogenesis and neuronal apoptosis, is predominantly expressed in the human hippocampus. Structural and functional neuroimaging studies have further shown that the hippocampus plays an important role in the performance on Raven's Progressive Matrices (RPM), a measure of reasoning ability and general fluid intelligence. Thus far, however, no study has examined the relationships between the SEMA5A gene polymorphism, hippocampal volume, and RPM performance. The current study collected both structural MRI, genetic, and behavioral data in 329 healthy Chinese adults, and examined associations between SEMA5A variants, hippocampal volume, and performance on RAPM (the advanced form of RPM). After controlling for intracranial volume (ICV), sex, and age, SEMA5A genetic polymorphism at the SNP rs42352 had the strongest association with hippocampal volume (p=0.00000552 and 0.000103 for right and left hippocampal volumes, respectively), with TT homozygotes having higher hippocampal volume than the other genotypes. Furthermore, there was a high correlation between right hippocampal volume and RAPM performance (r=0.42, p=0.0000509) for SEMA5A rs42352 TT homozygotes. This study provides the first evidence for the involvement of the SEMA5A gene in hippocampal structure and their interaction on RAPM performance. Future studies of the hippocampus-RPM associations should consider genetic factors as potential moderators. Copyright © 2013 Elsevier Inc. All rights reserved.

  1. Status of the KATRIN focal-plane detector

    Energy Technology Data Exchange (ETDEWEB)

    Seher, Agnes [Karlsruher Institute of Technology (KIT) (Germany). Institut fuer Kernphysik (IKP); Collaboration: KATRIN-Collaboration

    2016-07-01

    The KArlsruhe TRItium Neutrino (KATRIN) experiment aims to determine the mass of the electron anti-neutrino with a sensitivity of 200 meV/c{sup 2} by measuring the kinematics of tritium β-electrons close to the enpoint of the energy spectrum. The energy analysis of the experiment is performed with a high-resolution electrostatic spectrometer of MAC-E filter type which acts as an integranting high pass filter. Transmitted electrons are counted with a segmented silicon detector system located at the downstream end of the experiment. The detector system consists of two super-conducting solenoids (B{sub max}=6 T), a post-acceleration electrode, a detector wafer with silicon pixel-diodes, readout electronics as well as a calibration and monitoring devices. This talk gives an overview of the detector system and its current status as well as key performance parameters.

  2. SemaTyP: a knowledge graph based literature mining method for drug discovery.

    Science.gov (United States)

    Sang, Shengtian; Yang, Zhihao; Wang, Lei; Liu, Xiaoxia; Lin, Hongfei; Wang, Jian

    2018-05-30

    Drug discovery is the process through which potential new medicines are identified. High-throughput screening and computer-aided drug discovery/design are the two main drug discovery methods for now, which have successfully discovered a series of drugs. However, development of new drugs is still an extremely time-consuming and expensive process. Biomedical literature contains important clues for the identification of potential treatments. It could support experts in biomedicine on their way towards new discoveries. Here, we propose a biomedical knowledge graph-based drug discovery method called SemaTyP, which discovers candidate drugs for diseases by mining published biomedical literature. We first construct a biomedical knowledge graph with the relations extracted from biomedical abstracts, then a logistic regression model is trained by learning the semantic types of paths of known drug therapies' existing in the biomedical knowledge graph, finally the learned model is used to discover drug therapies for new diseases. The experimental results show that our method could not only effectively discover new drug therapies for new diseases, but also could provide the potential mechanism of action of the candidate drugs. In this paper we propose a novel knowledge graph based literature mining method for drug discovery. It could be a supplementary method for current drug discovery methods.

  3. Structural Basis of Semaphorin-Plexin Recognition and Viral Mimicry from Sema7A and A39R Complexes with PlexinC1

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Heli; Juo, Z. Sean; Shim, Ann Hye-Ryong; Focia, Pamela J.; Chen, Xiaoyan; Garcia, K. Christopher; He, Xiaolin (Stanford-MED); (NWU)

    2010-10-18

    Repulsive signaling by Semaphorins and Plexins is crucial for the development and homeostasis of the nervous, immune, and cardiovascular systems. Sema7A acts as both an immune and a neural Semaphorin through PlexinC1, and A39R is a Sema7A mimic secreted by smallpox virus. We report the structures of Sema7A and A39R complexed with the Semaphorin-binding module of PlexinC1. Both structures show two PlexinC1 molecules symmetrically bridged by Semaphorin dimers, in which the Semaphorin and PlexinC1 {beta} propellers interact in an edge-on, orthogonal orientation. Both binding interfaces are dominated by the insertion of the Semaphorin's 4c-4d loop into a deep groove in blade 3 of the PlexinC1 propeller. A39R appears to achieve Sema7A mimicry by preserving key Plexin-binding determinants seen in the mammalian Sema7A complex that have evolved to achieve higher affinity binding to the host-derived PlexinC1. The complex structures support a conserved Semaphorin-Plexin recognition mode and suggest that Plexins are activated by dimerization.

  4. Vastuseid Vaapo Vaheri küsimistele / Katrin Kalamees, Maritsa Lens

    Index Scriptorium Estoniae

    Kalamees, Katrin

    2003-01-01

    Arvustus: XX sajandi vene kirjandus. I, Luule / [koostanud Katrin Kalamees ja Maritsa Lens. Tallinn] : Avita, 2002; XX sajandi vene kirjandus. II, Proosa / [koostanud Katrin Kalamees ja Maritsa Lens. Tallinn] : Avita, 2002. Vastuseks Vaapo Vaheri arvustusele "Vene kirjanduse õpik lõhestab kirjanikud headeks ja pahadeks", Eesti Päevaleht : Arkaadia, 25. apr. 2003. Vt. ka vastukajad: Tuch, Boris. Dva toma oshibok // Estonija (2002) 28. apr., lk. 9; Vaher, Vaapo. Hüvad ärritunud pedagoogilised daamid, Eesti Päevaleht : Arkaadia, 2. mai, lk. 17

  5. Status of the cryogenic pumping section of the KATRIN experiment

    Energy Technology Data Exchange (ETDEWEB)

    Roettele, Carsten [Karlsruhe Institute of Technology (KIT) (Germany). Institut fuer Kernphysik (IKP); Collaboration: KATRIN-Collaboration

    2016-07-01

    The Karlsruhe Tritium Neutrino (KATRIN) experiment uses the kinematics of tritium β-decay to determine the electron antineutrino mass with a sensitivity of m{sub ν}=200 meV/c{sup 2} (90 % C.L.). In order to measure the decay electrons it is important to guide them adiabatically from the source to the spectrometer. In addition the diffusion of tritium into the spectrometers from the source has to be reduced by 14 magnitudes of order as tritium inside the spectrometers would induce additional background. For these two tasks the transport and pumping section were constructed. The last part of this section is the Cryogenic Pumping Section (CPS), which aims to reduce the residual gas flow by not less than seven orders of magnitude. For this a 3 K cold argon frost area (surface ∼ 2 m{sup 2}) will be prepared to adsorb the incoming tritium molecules. This talk will present the milestones which were reached since the CPS arrived on 30th July 2015 on KIT. Amongst others the calculations of the magnetic flux tube through the CPS based on as-built measurements of the coil geometries are presented.

  6. An angular selective electron gun for the KATRIN experiment

    Energy Technology Data Exchange (ETDEWEB)

    Zacher, Michael; Ortjohann, Hans-Werner; Steinbrink, Nicholas; Josten, Lorenz; Hannen, Volker; Weinheimer, Christian; Winzen, Daniel [Westfaelische Wilhelms-Universitaet, Muenster (Germany); Collaboration: KATRIN-Collaboration

    2013-07-01

    The KArlsruhe TRItium Neutrino experiment aims for a measurement of the electron anti-neutrino mass with a sensitivity of 200 meV/c{sup 2} (95% C.L.) by analysing the endpoint region of the tritium β-decay. The main spectrometer (MAC-E filter type, 23m length) is one of the central parts of the experiment, featuring an energy resolution of Δ E<1 eV. For commissioning of the spectrometer a well defined electron source is needed that allows to determine the transmission characteristics and compare the electromagnetic properties to simulations. For this purpose an angular selective electron gun was developed. A pulsed UV-Laser produces electrons via the photo-electric effect, which are then accelerated electrostatically in a magnetic field. It features a small energy spread, a sharp selectable emission angle and covers the whole magnetic flux tube of KATRIN. By that, the characteristics of the spectrometer can be investigated with high precision. The time structure of the electron pulses allows time of flight measurements, offering enhanced sensitivity. The talk gives an overview about the e-gun design and its properties.

  7. External meeting: KATRIN - direct measurement of neutrino masses with sub-eV sensitivity

    CERN Multimedia

    2007-01-01

    GENEVA UNIVERSITY - ECOLE DE PHYSIQUE Département de physique nucléaire et corspusculaire 24, Quai Ernest-Ansermet 1211 GENEVE 4 - Tél : 022 379 62 73 - Fax: 022 379 69 92 Wednesday 18 April 2007 PARTICLE PHYSICS SEMINAR at 17:00 - Stückelberg Auditorium KATRIN - direct measurement of neutrino masses with sub-eV sensitivity by Prof. Guido Drexlin, Karlsruhe Institute of Technology KIT The major scientific objective of the international Karlsruhe Tritum Neutrino (KATRIN) Experiment is the model independent measurement of the electron neutrino mass in tritium beta decay with a sensitivity of 200 meV. In the cosmological context, this allows an investigation of whether massive relic neutrinos left over from the Big Bang play a specific role as hot dark matter in the evolution of large scale structures of the universe. In particle physics KATRIN will allow for discrimination between different neutrino mass models (either of quasi-degenerate or hierarchical pattern).The key components of KATRIN comprise...

  8. Tritium ions in the Source and Transport Section (STS) of KATRIN

    Energy Technology Data Exchange (ETDEWEB)

    Klein, Manuel [Karlsruhe Institute of Technology (Germany); Collaboration: KATRIN-Collaboration

    2016-07-01

    The KArlsruhe TRItium Neutrino (KATRIN) experiment aims at the model independent measurement of the electron neutrino mass. It is designed for a neutrino mass sensitivity of 0.2 eV (90% CL) after three years of measurement time. KATRIN measures the end point of the tritium beta decay spectrum using a MAC-E filter and a Windowless Gaseous Tritium Source (WGTS). While neutral tritium gas molecules are pumped through the WGTS, the decay electrons are guided to the detector with a magnetic field. Tritium ions, however, also leave the WGTS following the magnetic field lines. For KATRIN measurements it is imperative to prevent tritium ions from reaching the detector or the spectrometers, where they could decay and cause an indistinguishable background. Ion blocking measures are implemented by electric blocking potentials and electric dipoles to drift out trapped ions. Their effective operation will be tested during KATRIN commissioning measurements: The ion flux between STS and spectrometers can be measured with the Forward Beam Monitor (FBM). It offers a manipulator arm to introduce a detector into the flux tube. For ion detection, a Faraday Cup for the FBM is being designed and constructed.

  9. Unustagem kõvaketas, kasutagem operatiivmälu! / Katrin Ruus

    Index Scriptorium Estoniae

    Ruus, Katrin

    2008-01-01

    Valik Mart Viljuse, Katrin Teesi, Piret Räni, Reimo Võsa-Tangsoo, Merle ja Erki Kannuse ning rühmituste Puhas Rõõm ja Infotankistid viimaste aastate töödest näituseprojektina "Operatiivmälu" Pärnu Kunstnike Maja galeriis ja Pärnu Linnagaleriis. 11 ill

  10. The cryogenic pumping section of KATRIN and the test experiment TRAP

    CERN Document Server

    Eichelhardt, F

    2011-01-01

    The Karlsruhe Tritium Neutrino experiment (KATRIN) employs a Cryogenic Pumping Section (CPS) at ~ 4.5 K to suppress the tritium penetration into the spectrometers. A test experiment (TRAP - Tritium Argon frost Pump) has been set up to investigate the tritium pumping performance of the CPS.

  11. Tähistaevata ela kui kotis / Tõnis Eenmäe, Katrin Jõgi

    Index Scriptorium Estoniae

    Eenmäe, Tõnis

    2010-01-01

    Astronoom Tõnis Eenmäe küsib ja vastab ülemäärase valgustatuse ehk valgusreostuse kohta: mõjust elukeskkonnale, mõõtmisviisid. Hugo Teffneri gümnaasiumi õpilase Katrin Jõgi kiri loodushuvilisele sõbrale valgusreostusest

  12. V Las-Vegas so statujei Svobodõ / Katrin Sangla, Gerly Tinn, Tamara Korjagina ; interv. Alina Zelimhanova

    Index Scriptorium Estoniae

    Sangla, Katrin

    2002-01-01

    Küsitletakse soengukunsti maailmameistrivõistlustel Hair World 2002 Las-Vegases osalenud juuksur Tamara Korjaginat, jumestuskunstnik Katrin Sanglat ja moekunstnik Gerly Tinni võistluse kohta. Saavutasid võiskondlikus arvestuses kolmanda koha

  13. TAB sümpoosion tõi Kultuurikatlasse üle 300 inimese = TAB symposium attracted more than 300 participants / Katrin Koov

    Index Scriptorium Estoniae

    Koov, Katrin, 1973-

    2011-01-01

    8.-11. septembrini 2011 toimunud 1. Tallinna arhitektuuribiennaali sümpoosionist, mille teemaks oli maastikuurbanism (landscape urbanism). Kuraator Katrin Koov. Esinejatest, ettekannetest, maasikuurbanismist

  14. Sema4D, the ligand for Plexin B1, suppresses c-Met activation and migration and promotes melanocyte survival and growth.

    Science.gov (United States)

    Soong, Joanne; Chen, Yulin; Shustef, Elina M; Scott, Glynis A

    2012-04-01

    Semaphorins are secreted and membrane-bound proteins involved in neural pathfinding, organogenesis, and tumor progression, through Plexin and neuropilin receptors. We recently reported that Plexin B1, the Semaphorin 4D (Sema4D) receptor, is a tumor-suppressor protein for melanoma, which functions, in part, through inhibition of the oncogenic c-Met tyrosine kinase receptor. In this report, we show that Sema4D is a protective paracrine factor for normal human melanocyte survival in response to UV irradiation, and that it stimulates proliferation and regulates the activity of the c-Met receptor. c-Met receptor signaling stimulates melanocyte migration, partly through downregulation of the cell adhesion molecule E-cadherin. Sema4D suppressed activation of c-Met in response to its ligand, hepatocyte growth factor (HGF), and partially blocked the suppressive effects of HGF on E-cadherin expression in melanocytes and HGF-dependent migration. These data demonstrate a role for Plexin B1 in maintenance of melanocyte survival and proliferation in the skin, and suggest that Sema4D and Plexin B1 act cooperatively with HGF and c-Met to regulate c-Met-dependent effects in human melanocytes. Because our data show that Plexin B1 is profoundly downregulated by UVB in melanocytes, loss of Plexin B1 may accentuate HGF-dependent effects on melanocytes, including melanocyte migration.

  15. Transcription of a novel mouse semaphorin gene, M-semaH, correlates with the metastatic ability of mouse tumor cell lines

    DEFF Research Database (Denmark)

    Christensen, C R; Klingelhöfer, Jörg; Tarabykina, S

    1998-01-01

    identified a novel member of the semaphorin/collapsin family in the two metastatic cell lines. We have named it M-semaH. Northern hybridization to a panel of tumor cell lines revealed transcripts in 12 of 12 metastatic cell lines but in only 2 of 6 nonmetastatic cells and none in immortalized mouse...

  16. Teaching Literacy Skills to French Minimally Verbal School-Aged Children with Autism Spectrum Disorders with the Serious Game SEMA-TIC: An Exploratory Study

    Directory of Open Access Journals (Sweden)

    Sylvie Serret

    2017-09-01

    Full Text Available Learning to read is very challenging for children with Autism Spectrum Disorders (ASD, but also very important, as it can give them access to new knowledge. This is even more challenging in minimally verbal children, who do not have the verbal abilities to learn through usual methods. To address the learning of literacy skills in French minimally verbal school-aged children with ASD, we designed the serious game SEMA-TIC, which relies on non-verbal cognitive skills and uses specific learning strategies adapted to the features of autistic individuals. This study investigated the usability of SEMA-TIC (in terms of adaptability, efficiency, and effectiveness for the acquisition of literacy skills in French minimally verbal school-aged children with ASD. Twenty-five children with ASD and no functional language participated in the study. Children in the training group received the SEMA-TIC training over 23 weeks (on average, while no intervention was provided to children in the non-training group. Results indicated that SEMA-TIC presents a suitable usability, as all participants were able to play (adaptability, to complete the training (efficiency and to acquire significant literacy skills (effectiveness. Indeed, the literacy skills in the training group significantly improved after the training, as measured by specific experimental tasks (alphabet knowledge, word reading, word-non-word discrimination, sentence reading and word segmentation; all p ≤ 0.001 compared to the non-training group. More importantly, 3 out of 12 children of the training group could be considered as word decoders at the end of the intervention, whereas no children of the non-training group became able to decode words efficiently. The present study thus brings preliminary evidence that French minimally verbal school-aged children with ASD are able to learn literacy skills through SEMA-TIC, a specific computerized intervention consisting in a serious game based on non

  17. Teaching Literacy Skills to French Minimally Verbal School-Aged Children with Autism Spectrum Disorders with the Serious Game SEMA-TIC: An Exploratory Study

    Science.gov (United States)

    Serret, Sylvie; Hun, Stéphanie; Thümmler, Susanne; Pierron, Prescillia; Santos, Andreia; Bourgeois, Jérémy; Askenazy, Florence

    2017-01-01

    Learning to read is very challenging for children with Autism Spectrum Disorders (ASD), but also very important, as it can give them access to new knowledge. This is even more challenging in minimally verbal children, who do not have the verbal abilities to learn through usual methods. To address the learning of literacy skills in French minimally verbal school-aged children with ASD, we designed the serious game SEMA-TIC, which relies on non-verbal cognitive skills and uses specific learning strategies adapted to the features of autistic individuals. This study investigated the usability of SEMA-TIC (in terms of adaptability, efficiency, and effectiveness) for the acquisition of literacy skills in French minimally verbal school-aged children with ASD. Twenty-five children with ASD and no functional language participated in the study. Children in the training group received the SEMA-TIC training over 23 weeks (on average), while no intervention was provided to children in the non-training group. Results indicated that SEMA-TIC presents a suitable usability, as all participants were able to play (adaptability), to complete the training (efficiency) and to acquire significant literacy skills (effectiveness). Indeed, the literacy skills in the training group significantly improved after the training, as measured by specific experimental tasks (alphabet knowledge, word reading, word-non-word discrimination, sentence reading and word segmentation; all p ≤ 0.001) compared to the non-training group. More importantly, 3 out of 12 children of the training group could be considered as word decoders at the end of the intervention, whereas no children of the non-training group became able to decode words efficiently. The present study thus brings preliminary evidence that French minimally verbal school-aged children with ASD are able to learn literacy skills through SEMA-TIC, a specific computerized intervention consisting in a serious game based on non-verbal cognitive

  18. Teaching Literacy Skills to French Minimally Verbal School-Aged Children with Autism Spectrum Disorders with the Serious Game SEMA-TIC: An Exploratory Study.

    Science.gov (United States)

    Serret, Sylvie; Hun, Stéphanie; Thümmler, Susanne; Pierron, Prescillia; Santos, Andreia; Bourgeois, Jérémy; Askenazy, Florence

    2017-01-01

    Learning to read is very challenging for children with Autism Spectrum Disorders (ASD), but also very important, as it can give them access to new knowledge. This is even more challenging in minimally verbal children, who do not have the verbal abilities to learn through usual methods. To address the learning of literacy skills in French minimally verbal school-aged children with ASD, we designed the serious game SEMA-TIC, which relies on non-verbal cognitive skills and uses specific learning strategies adapted to the features of autistic individuals. This study investigated the usability of SEMA-TIC (in terms of adaptability, efficiency, and effectiveness) for the acquisition of literacy skills in French minimally verbal school-aged children with ASD. Twenty-five children with ASD and no functional language participated in the study. Children in the training group received the SEMA-TIC training over 23 weeks (on average), while no intervention was provided to children in the non-training group. Results indicated that SEMA-TIC presents a suitable usability, as all participants were able to play (adaptability), to complete the training (efficiency) and to acquire significant literacy skills (effectiveness). Indeed, the literacy skills in the training group significantly improved after the training, as measured by specific experimental tasks (alphabet knowledge, word reading, word-non-word discrimination, sentence reading and word segmentation; all p ≤ 0.001) compared to the non-training group. More importantly, 3 out of 12 children of the training group could be considered as word decoders at the end of the intervention, whereas no children of the non-training group became able to decode words efficiently. The present study thus brings preliminary evidence that French minimally verbal school-aged children with ASD are able to learn literacy skills through SEMA-TIC, a specific computerized intervention consisting in a serious game based on non-verbal cognitive

  19. Reduction in cryptosporidiosis associated with introduction of enhanced filtration of drinking water at Loch Katrine, Scotland.

    Science.gov (United States)

    Pollock, K G J; Young, D; Robertson, C; Ahmed, S; Ramsay, C N

    2014-01-01

    Previous evidence has suggested an association between cryptosporidiosis and consumption of unfiltered drinking water from Loch Katrine in Scotland. Before September 2007, the water was only micro-strained and chlorinated; however, since that time, coagulation and rapid gravity filtration have been installed. In order to determine risk factors associated with cryptosporidiosis, including drinking water, we analysed data on microbiologically confirmed cases of cryptosporidiosis from 2004 to 2010. We identified an association between the incidence of cryptosporidiosis and unfiltered Loch Katrine drinking water supplied to the home (odds ratio 1.86, 95% confidence interval 1.11-3.11, P = 0.019). However, while filtration appears to be associated with initially reduced rates of cryptosporidiosis, evidence suggests it may paradoxically make those consumers more susceptible to other transmission routes in the long-term. These findings support implementation of similar treatment for other unfiltered drinking-water supplies, as a means of reducing cryptosporidiosis associated with drinking water.

  20. Commissioning of the KATRIN Raman system for monitoring of the WGTS gas composition

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, Sebastian; Bornschein, Beate; James, Timothy M.; Off, Andreas; Rupp, Simone; Seitz-Moskaliuk, Hendrik; Sturm, Michael; Wecker, Matthias [Karlsruhe Institute of Technology (Germany); Schloesser, Magnus [Universidad Complutense de Madrid (Spain); Karlsruhe Institute of Technology (Germany); Telle, Helmut H. [Universidad Complutense de Madrid (Spain)

    2015-07-01

    The Karlsruhe Tritium Neutrino (KATRIN) Experiment aims at determining the neutrino mass by the investigation of the endpoint energy-region of the tritium β-spectrum. Tritium in its molecular form ({sup 3}H{sub 2}) is injected into the Windowless Gaseous Tritium Source (WGTS) of KATRIN, and thus molecular effects, e.g. ro-vibrational excitations levels, have to be considered in the neutrino mass analysis in order to reach the design sensitivity of 200 meV/c{sup 2} (90% C.L.). As the source gas also contains impurities of the other hydrogen isotopes protium and deuterium - giving rise to different molecular excitation levels - continuous and precise monitoring of the source gas composition is required. Raman spectroscopy is the method of choice for this task as it is an inline and non-contact analysis method. In this talk, results from the recently performed commissioning phase of the KATRIN Raman system are presented: over the course of more than 50 days, consecutive Raman spectra (recorded with acquisition times of 60 s) of circulating tritium gas were acquired and analysed in real-time. In addition, valuable information on the system performance during long-term operation was gained.

  1. Methylation of the RASSF1A, RARβ2, and SEMA3B genes in epithelial breast and ovarian tumors, and in patients with polyneoplasia

    Directory of Open Access Journals (Sweden)

    T. P. Kazubskaya

    2012-01-01

    Full Text Available The methylation status of the tumor suppressor genes RASSF1A, RARβ2, and SEMA3B was studied in the samples of cancer and its histologically normal tissue of the breast and ovaries. The high rate of abnormal methylation of the CpG islet in the RASSF1A, RARβ2, and SEMA3B genes was found in the tumors of the breast (78% (32/41, 46% (26/56, and 35% (22/65, respectively and ovaries 73% (33/45, 30% (15/50, and 50% (25/51. Hypermethylation in the CpG islets belonging to the RASSF1A and RARβ2 genes was first ascertained in 90% of the patients with polyneoplasms involving the breast and ovaries. Abnormal methylation of the promotor region of the RASSF1A gene was shown to be detectable in preclinical-stage and anaplasia-degree breast and ovarian cancer. There was a correlation of the rate of methylation in the promoter regions of the RARβ2 and SEMA3B genes with clinical-stage and anaplasia-degree breast and ovarian cancer. Analysis of gene methylation in biological fluids provides considerable opportunity to use methylation of DNA as a marker in clinical practice.

  2. Precision monitoring and calibration of the high-voltage for the KATRIN experiment; Praezisionsueberwachung und Kalibration der Hochspannung fuer das KATRIN-Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Thuemmler, T.

    2007-11-12

    The goal of the KATRIN(KArlsruhe TRIritium Neutrino) Experiment is to directly determine the neutrino rest mass from the kinematics of the tritium-{beta}-decay. KATRIN uses the high resolution and luminosity of a spectrometer following the MAC-E filter principle. Based on the experience of the successful predecessor experiments in Mainz and Troisk and the improved experimental technology, KATRIN aims to reach a sensitivity on the neutrino mass of 0.2 eV/c{sup 2} (90% C.L.). One of the few systematic uncertainties that have to be reduced to meet this goal is the uncertainty of measuring and monitoring the potential of the electrostatic filter of the spectrometer. In tritium measurement mode voltages of about U{sub 0} =-18.6 kV have to be permanently monitored with a maximum uncertainty of 3.3 ppm ({approx} 61mV at U{sub 0}), in order not to add more than {delta}m{sup 2}{sub {nu}{sub ec}}{sup 4} {<=} 0.0075 eV{sup 2} to the total systematic uncertainty. The goal of this work is to build a new precision high voltage divider in cooperation with PTB Braunschweig that reaches an uncertainty of about 1 ppm at voltages up to 35 kV. The divider is based on a new type of precision resistors, which have been screened with respect to their warm up drift and their temperature coefficient at the ppm level. By combining 100 of the best matching samples, the mutual warm up effect could be reduced to a computed value of <0.02 ppm. The precision resistors are mounted in a shielded and temperature stabilized vessel under N{sub 2} gas. The properties of both installed low voltage outputs with the ratios 1972:1 and 3944:1 have been repeatedly calibrated with about one year time difference at the DC high voltage laboratory (division 2.31) of PTB. The performance of the new divider in real measurements has been tested with the prototype of the new condensed {sup 83m}Kr calibration source (CKrS) [Ost08] at the Mainz spectrometer. Detailed stability investigations of the energy of the {sup

  3. Jutuvõistluse "Musta mantliga mees" võitis Katrin Johanson

    Index Scriptorium Estoniae

    2007-01-01

    Eduard Vilde muuseumi poolt läbi viidud krimi- ja põnevusjuttude võistlusest "Musta mantliga mees". Žürii: Karl Martin Sinijärv, Juhan Habicht, Paul Pajos, Rebekka Lotman, Kristin Rammus, Piret Meos.Võitja: Katrin Johanson, teine koht: Taavet Kase, kolmas koht: Imre Kõuts. Ajalehe "Postimees" eriauhinnad said: Juhan Voolaid, Hella Riisalu, Stina Maria Vilt, Sirle Poikkanen, Märt Kivimäe. Tallinna noorte infokeskuse auhinnad: Juhan Voolaid, Sirle Poikkalainen, Lilli Anderson, Aino Rätsep. Eduard Vilde muuseumi eriauhinnad: Merilin Jürjo, Laura Pirso

  4. Miks meile vaja maastikuarhitektuuri? = Why do we need landscape architecture? / Reinhard Micheller, Günther Schalk, Katrin Koov

    Index Scriptorium Estoniae

    Micheller, Reinhard, 1977-

    2013-01-01

    EKA arhitektuuri ja linnaplaneerimise osakonna III kursuse 2009-2012 aastail erialase projekteerimise ülesande raames on vestlusringis maastikuarhitektuurse osa juhendajad Reinhard Micheller ja Günther Schalk (michellerundschalk, München) ning Katrin Koov (KAVAKAVA, EKA maastikuarhitektuuri õppekava juht)

  5. Ruumi kohta arvamuse avaldamiseks ei pea olema arhitekt / Katrin Koov, Ave Kongo ; intervjueerinud Merle Karro-Kalberg

    Index Scriptorium Estoniae

    Koov, Katrin, 1973-

    2016-01-01

    Erahuvikoolina tegutseva arhitektuurikooli eestvedamisel töötatakse välja ruumiõppe valikainemoodulit gümnaasiumile. Ruumiõppest räägivad arhitektide liidu president, arhitektuurikooli õpetaja Katrin Koov ja Saue gümnaasiumi kunstiõpetaja Ave Kongo

  6. Mida teie oma tervise heaks teete? / Ly Jagor, Ülle Mihhailova, Ene Pill, Katrin Käbin...[jt.

    Index Scriptorium Estoniae

    2008-01-01

    Küsimusele vastavad Pärnu Õppenõustamiskeskuse psühholoog Ly Jagor, Maasika lasteaia juhataja asetäitja Ülle Mihhailova, Tallinna Perekeskuse ja Tähetorni lastekeskuse psühholoog Ene Pill, Tallinna Nõmme Noortemaja väikelaste ringijuht Katrin Käbin, Tääksi Põhikooli õpetaja Silva Kolk

  7. Kuhu lähed, Kultuurikatel? / Thuur Caris, Renger Koning, Arne Lösekann ; interv. Katrin Koov, Regina Viljasaar

    Index Scriptorium Estoniae

    Caris, Thuur

    2008-01-01

    Endise Tallinna soojuselektrijaama kompleksis asuva Kultuurikatla ruumide võimalusi uuriv workshop, korraldajaks MTÜ Kultuurikatel koos Kavakava arhitektide Siiri Vallneri ja Katrin Kooviga. Hollandi meediakunstnik Thuur Caris ja helilooja ning helidisainer Renger Koning tutvustavad Groningeni Pudingivabrikut. Saksa arhitekt ja kunstnik Arne Lösekann tutvustab Kubasta kunstikeskust Hamburgis

  8. A pulsed, mono-energetic and angular-selective UV photo-electron source for the commissioning of the KATRIN experiment

    Energy Technology Data Exchange (ETDEWEB)

    Behrens, J. [Institut fuer Kernphysik, WWU Muenster, Muenster (Germany); Karlsruhe Institute of Technology, IEKP, Eggenstein-Leopoldshafen (Germany); Ranitzsch, P.C.O.; Hannen, V.; Ortjohann, H.W.; Rest, O.; Winzen, D.; Zacher, M.; Weinheimer, C. [Institut fuer Kernphysik, WWU Muenster, Muenster (Germany); Beck, M. [Institut fuer Kernphysik, WWU Muenster, Muenster (Germany); Johannes-Gutenberg Universitaet, Institut fuer Physik, Mainz (Germany); Beglarian, A. [Karlsruhe Institute of Technology, IPE, Eggenstein-Leopoldshafen (Germany); Erhard, M.; Groh, S.; Kraus, M. [IEKP, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen (Germany); Schloesser, K.; Thuemmler, T. [Karlsruhe Institute of Technology, IKP, Karlsruhe (Germany); Valerius, K. [Institut fuer Kernphysik, WWU Muenster, Muenster (Germany); Karlsruhe Institute of Technology, IKP, Karlsruhe (Germany); Wierman, K.; Wilkerson, J.F. [University of North Carolina, Department of Physics and Astronomy, Chapel Hill, NC (United States)

    2017-06-15

    The KATRIN experiment aims to determine the neutrino mass scale with a sensitivity of 200 meV/c{sup 2} (90% C.L.) by a precision measurement of the shape of the tritium β-spectrum in the endpoint region. The energy analysis of the decay electrons is achieved by a MAC-E filter spectrometer. To determine the transmission properties of the KATRIN main spectrometer, a mono-energetic and angular-selective electron source has been developed. In preparation for the second commissioning phase of the main spectrometer, a measurement phase was carried out at the KATRIN monitor spectrometer where the device was operated in a MAC-E filter setup for testing. The results of these measurements are compared with simulations using the particle-tracking software ''Kassiopeia'', which was developed in the KATRIN collaboration over recent years. (orig.)

  9. Stability measurements of the electron gun for the KATRIN rear section

    Energy Technology Data Exchange (ETDEWEB)

    Ebenhoech, Sylvia [Karlsruhe Institute of Technology (KIT) (Germany). Institute for Technical Physics (ITEP), Tritium Laboratory Karlsruhe (TLK); Collaboration: KATRIN-Collaboration

    2016-07-01

    The aim of the KArlsruhe TRItium Neutrino (KATRIN) experiment is to determine the antineutrino mass with a sensitivity of 0.2 eV (90 % C.L.) by high-precision spectroscopy close to the tritium beta decay endpoint at 18.6 keV. To achieve the sensitivity aim both statistical and systematic uncertainties must be minimized. One contribution to the systematic error are uncertainties in the column density of the tritium source or in the source activity. In order to detect and monitor changes in the tritium source the Rear Section, which is integrated at the rear end of the KATRIN setup, is used. The Rear Section includes an angular selective electron gun (e-gun) based on the photoelectric effect. With the e-gun it will be possible e.g. to achieve a precise calibration of the column source density. To achieve the requirements on the e-gun a stable UV light source is essential to produce photoelectrons. The presentation focuses on the setup of the e-gun and intensity stability measurements of the UV light source setup.

  10. Design of a pulsed angular selective electron gun for the KATRIN main spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Winzen, Daniel; Hannen, Volker; Ortjohann, Hans-Werner; Zacher, Michael; Weinheimer, Christian [Institut fuer Kernphysik, Westfaelische Wilhelms-Universitaet, Muenster (Germany); Collaboration: KATRIN-Collaboration

    2012-07-01

    The KATRIN (KArlsruhe TRItium Neutrino mass) experiment will study the tritium {beta}-spectrum near the endpoint of 18.6 keV, aiming to measure the mass of the electron antineutrino. Using an electrostatic retarding spectrometer (MAC-E-Filter), the projected sensitivity for m{sub ve} is 200 meV/c{sup 2} at 90% C.L. In order to map out the electric and magnetic fields in the main spectrometer, an angular selective electron gun is currently being developed. The e-gun uses an UV-Laser to produce electrons via the photo-electric effect from a copper substrate which are then accelerated electrostatically. It features a small energy spread of approx. 0.1 eV, a sharp emission angle and will be able to cover the whole magnetic flux tube of KATRIN. Using a pulsed laser it is also possible to investigate the time of flight (TOF) of electrons through the spectrometer, offering enhanced sensitivity to spectrometer properties far away from the analysing plane. By comparing information from transmission function measurements and TOF data with Monte Carlo simulations of the setup, one will be able to achieve a detailed understanding of the spectrometer properties.

  11. Overview of recent and current spectroscopic investigations with hydrogen isotopologues for KATRIN

    Energy Technology Data Exchange (ETDEWEB)

    Brunst, Tim; Mirz, Sebastian; Groessle, Robin; Krasch, Bennet [Karlsruhe Institute of Technology KIT (Germany). Institute for Technical Physics (ITEP), Tritium Laboratory Karlsruhe (TLK); Collaboration: KATRIN-Collaboration

    2016-07-01

    The Karlsruhe Tritium Neutrino Experiment (KATRIN) investigates the energy spectrum of the tritium β decay near its energetic endpoint in order to determine the electron anti-neutrino mass with a sensitivity of 200 meV/c{sup 2} (90 % C.L.). Therefore, molecular tritium gas is decaying in a windowless gaseous tritium source (WGTS). The physical properties of the gas in the WGTS, like composition, ortho/para ratio or rotational population, need to be stabilised on a 10{sup -3} level due to their direct impact on the initial state distribution of the investigated β decay. In order to obtain a complete model of the molecular processes in the sample various spectroscopic measurements of mixtures with non-radioactive isotopologues (H{sub 2},HD,D{sub 2}) have been using IR spectroscopy in the liquid at temperatures <25 K and Raman spectroscopy in the gaseous phase at room temperature. This poster presents an overview of recent and current investigations with TApIR: The investigation of dimer and cluster formation under KATRIN conditions, as well as the ongoing task to investigate mixtures beyond the thermal equilibrium with highly concentrated HD and the design of a tritium compatible system for temperatures between (15-293) K.

  12. Novel laser ellipsometry method for the KATRIN condensed {sup 83m}Kr source

    Energy Technology Data Exchange (ETDEWEB)

    Zboril, Miroslav [Muenster Univ. (Germany). Inst. fuer Kernphysik; Collaboration: KATRIN-Collaboration

    2013-07-01

    One of the systematic effects in the neutrino mass experiment KATRIN are the fluctuations of the electric retarding potential which is experienced by the tritium β electrons on their path through the spectrometer. For the purpose of long-term monitoring of the energy scale stability several calibration electron sources will be utilised at KATRIN. One of them is the condensed {sup 83m}Kr source based on a frozen {sup 83m}Kr film on a HOPG backing at about 20 K. The isomeric state decays via a cascade of highly converted transitions, yielding conversion electron lines with energies ranging from 7.5 keV to 32.1 keV, useful for the energy calibration. The cleanliness of the HOPG backing is crucial as any adsorption of residual gas would shift the kinetic energy of the conversion electrons. The backing is cleaned via laser ablation and resistive heating. The cleanliness is checked via a novel method of laser ellipsometry where the polarisation analysis takes place directly in ultrahigh vacuum. The polarisation analysis is realised by an analyser and light detector at 90 K embedded in the cold baffle. This method allows to determine film thicknesses with a resolution of better than an atomic monolayer. As a byproduct it can be also used to determine the indices of refraction of condensed krypton and of the HOPG backing. The main features of the calibration source will be reviewed and the results of test measurements will be presented.

  13. Removal of stored particle background via the electric dipole method in the KATRIN main spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Hilk, Daniel [Institut fuer Experimentelle Kernphysik, KIT, Karlsruhe (Germany); Collaboration: KATRIN-Collaboration

    2016-07-01

    The goal of the KArlsruhe TRItium Neutrino (KATRIN) experiment is to determine the effective mass of the electron anti neutrino by measuring the electron energy spectrum of tritium beta decay near the endpoint. The goal is to reach a sensitivity on the neutrino mass of 200 meV for which a low background level of 10{sup -2} counts per second is mandatory. Electrons from single radioactive decays of radon and tritium in the KATRIN main spectrometer with energies in the keV range can be magnetically stored for hours. While cooling down via ionization of residual gas molecules, they produce hundreds of secondary electrons, which can reach the detector and contribute to the background signals. In order to suppress this background component, several methods are investigated to remove stored electrons, such as the application of an electric dipole field and the application of magnetic pulses. This talk introduces the mechanism of background production due to stored electrons and their removal by the electric dipole method in the main spectrometer. In context of the spectrometer- and detector-commissioning phase in summer 2015, measurement results of the application of the electric dipole method are presented.

  14. The source of monoenergetic electrons for the monitoring of spectrometer in the KATRIN neutrino experiment

    CERN Document Server

    Slezák, Martin

    The international project KATRIN (KArlsruhe TRItium Neutrino experiment) is a next-generation tritium $\\beta$-decay experiment. It is designed to measure the electron anti-neutrino mass by means of a unique electron spectrometer with sensitivity of 0.2 eV/c$^2$. This is an improvement of one order of magnitude over the last results. Important part of the measurement will rest in continuous precise monitoring of high voltage of the KATRIN main spectrometer. The monitoring will be done by means of conversion electrons emitted from a solid source based on $^{83}$Rb decay. Properties of several of these sources are studied in this thesis by means of the semiconductor $\\gamma$-ray spectroscopy. Firstly, measurement of precise energy of the 9.4 keV nuclear transition observed in $^{83}$Rb decay, from which the energy of conversion electrons is derived, is reported. Secondly, measurement of activity distribution of the solid sources by means of the Timepix detector is described. Finally, a report on measurement of r...

  15. A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system.

    Science.gov (United States)

    Zielonka, Matthias; Xia, Jingjing; Friedel, Roland H; Offermanns, Stefan; Worzfeld, Thomas

    2010-09-10

    Plexins serve as receptors for semaphorins and play important roles in the developing nervous system. Plexin-B2 controls decisive developmental programs in the neural tube and cerebellum. However, whether Plexin-B2 also regulates biological functions in adult nonneuronal tissues is unknown. Here we show by two methodologically independent approaches that Plexin-B2 is expressed in discrete cell types of several nonneuronal tissues in the adult mouse. In the vasculature, Plexin-B2 is selectively expressed in functionally specialized endothelial cells. In endocrine organs, Plexin-B2 localizes to the pancreatic islets of Langerhans and to both cortex and medulla of the adrenal gland. Plexin-B2 expression is also detected in certain types of immune and epithelial cells. In addition, we report on a systematic comparison of the expression patterns of Plexin-B2 and its ligand Sema4C, which show complementarity or overlap in some but not all tissues. Furthermore, we demonstrate that Plexin-B2 and its family member Plexin-B1 display largely nonredundant expression patterns. This work establishes Plexin-B2 and Sema4C as potential regulators of the vascular and endocrine system and provides an anatomical basis to understand the biological functions of this ligand-receptor pair. Copyright 2010 Elsevier Inc. All rights reserved.

  16. Electron spectroscopy measurements with a shifted analyzing plane setting in the KATRIN main spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Dyba, Stephan [Institut fuer Kernphysik, Uni Muenster (Germany); Collaboration: KATRIN-Collaboration

    2016-07-01

    With the KATRIN (KArlsruhe TRItium Neutrino) experiment the endpoint region of the tritium beta decay will be measured to determine the electron-neutrino mass with a sensitivity of 200 meV/c{sup 2} (90% C.L.). For the high precision which is needed to achieve the sub-eV range a MAC-E filter type spectrometer is used to analyze the electron energy. To understand the various background contributions inside the spectrometer vessel different electric and magnetic field settings were investigated during the last commissioning phase. This talk will focus on the so called shifted analyzing plane measurement in which the field settings were tuned in a way to provide non standard potential barriers within the spectrometer. The different settings allowed to perform a spectroscopic measurement, determining the energy spectrum of background electrons born within the spectrometer.

  17. Uhked naised / Kozik, Eerika; Tomingas, Triin; Sepp, Karin; Liik, Kadi; Kliimask, Katrin; Saunpere, Anne ; tekst Kärt Kross

    Index Scriptorium Estoniae

    2007-01-01

    Mille üle oled enda juures tõeliselt uhke, mida võid enda kiituseks öelda? Küsimusele vastavad Starland Salongi omanik ja Loyd Tootmine OÜ osanik Eerika Kozik, psühholoog Triin Tomingas, Kontuur Leo Burnett projektidirektor Karin Sepp, Tallinna Ülikooli õppejõud Kadi Liik, AS Koolibri turundusjuht Katrin Kliimask ja eraettevõtja Anne Saunpere

  18. Statistical sensitivity on right-handed currents in presence of eV scale sterile neutrinos with KATRIN

    Science.gov (United States)

    Steinbrink, Nicholas M. N.; Glück, Ferenc; Heizmann, Florian; Kleesiek, Marco; Valerius, Kathrin; Weinheimer, Christian; Hannestad, Steen

    2017-06-01

    The KATRIN experiment aims to determine the absolute neutrino mass by measuring the endpoint region of the tritium β-spectrum. As a large-scale experiment with a sharp energy resolution, high source luminosity and low background it may also be capable of testing certain theories of neutrino interactions beyond the standard model (SM). An example of a non-SM interaction are right-handed currents mediated by right-handed W bosons in the left-right symmetric model (LRSM). In this extension of the SM, an additional SU(2)R symmetry in the high-energy limit is introduced, which naturally includes sterile neutrinos and predicts the seesaw mechanism. In tritium β decay, this leads to an additional term from interference between left- and right-handed interactions, which enhances or suppresses certain regions near the endpoint of the beta spectrum. In this work, the sensitivity of KATRIN to right-handed currents is estimated for the scenario of a light sterile neutrino with a mass of some eV. This analysis has been performed with a Bayesian analysis using Markov Chain Monte Carlo (MCMC). The simulations show that, in principle, KATRIN will be able to set sterile neutrino mass-dependent limits on the interference strength. The sensitivity is significantly increased if the Q value of the β decay can be sufficiently constrained. However, the sensitivity is not high enough to improve current upper limits from right-handed W boson searches at the LHC.

  19. Statistical sensitivity on right-handed currents in presence of eV scale sterile neutrinos with KATRIN

    International Nuclear Information System (INIS)

    Steinbrink, Nicholas M.N.; Weinheimer, Christian; Glück, Ferenc; Valerius, Kathrin; Heizmann, Florian; Kleesiek, Marco; Hannestad, Steen

    2017-01-01

    The KATRIN experiment aims to determine the absolute neutrino mass by measuring the endpoint region of the tritium β-spectrum. As a large-scale experiment with a sharp energy resolution, high source luminosity and low background it may also be capable of testing certain theories of neutrino interactions beyond the standard model (SM). An example of a non-SM interaction are right-handed currents mediated by right-handed W bosons in the left-right symmetric model (LRSM). In this extension of the SM, an additional SU(2) R symmetry in the high-energy limit is introduced, which naturally includes sterile neutrinos and predicts the seesaw mechanism. In tritium β decay, this leads to an additional term from interference between left- and right-handed interactions, which enhances or suppresses certain regions near the endpoint of the beta spectrum. In this work, the sensitivity of KATRIN to right-handed currents is estimated for the scenario of a light sterile neutrino with a mass of some eV. This analysis has been performed with a Bayesian analysis using Markov Chain Monte Carlo (MCMC). The simulations show that, in principle, KATRIN will be able to set sterile neutrino mass-dependent limits on the interference strength. The sensitivity is significantly increased if the Q value of the β decay can be sufficiently constrained. However, the sensitivity is not high enough to improve current upper limits from right-handed W boson searches at the LHC.

  20. Statistical sensitivity on right-handed currents in presence of eV scale sterile neutrinos with KATRIN

    Energy Technology Data Exchange (ETDEWEB)

    Steinbrink, Nicholas M.N.; Weinheimer, Christian [Institute for Nuclear Physics, University of Münster, Wilhelm Klemm-Str. 9, 41849 Münster (Germany); Glück, Ferenc; Valerius, Kathrin [Institute for Nuclear Physics, Karlsruhe Institute of Technology, P.O. Box 3640, 76021 Karlsruhe (Germany); Heizmann, Florian; Kleesiek, Marco [Institute of Experimental Nuclear Physics, Karlsruhe Institute of Technology, P.O. Box 3640, 76021 Karlsruhe (Germany); Hannestad, Steen, E-mail: n.steinbrink@uni-muenster.de, E-mail: ferenc.glueck@kit.edu, E-mail: florian.heizmann@kit.edu, E-mail: marco.kleesiek@kit.edu, E-mail: kathrin.valerius@kit.edu, E-mail: weinheimer@uni-muenster.de, E-mail: steen@phys.au.dk [Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, 8000 Aarhus C (Denmark)

    2017-06-01

    The KATRIN experiment aims to determine the absolute neutrino mass by measuring the endpoint region of the tritium β-spectrum. As a large-scale experiment with a sharp energy resolution, high source luminosity and low background it may also be capable of testing certain theories of neutrino interactions beyond the standard model (SM). An example of a non-SM interaction are right-handed currents mediated by right-handed W bosons in the left-right symmetric model (LRSM). In this extension of the SM, an additional SU(2){sub R} symmetry in the high-energy limit is introduced, which naturally includes sterile neutrinos and predicts the seesaw mechanism. In tritium β decay, this leads to an additional term from interference between left- and right-handed interactions, which enhances or suppresses certain regions near the endpoint of the beta spectrum. In this work, the sensitivity of KATRIN to right-handed currents is estimated for the scenario of a light sterile neutrino with a mass of some eV. This analysis has been performed with a Bayesian analysis using Markov Chain Monte Carlo (MCMC). The simulations show that, in principle, KATRIN will be able to set sterile neutrino mass-dependent limits on the interference strength. The sensitivity is significantly increased if the Q value of the β decay can be sufficiently constrained. However, the sensitivity is not high enough to improve current upper limits from right-handed W boson searches at the LHC.

  1. Calibration of the precision high voltage dividers of the KATRIN experiment

    Energy Technology Data Exchange (ETDEWEB)

    Rest, Oliver [Institut fuer Kernphysik, Westfaelische Wilhelms-Universitaet Muenster (Germany); Collaboration: KATRIN-Collaboration

    2016-07-01

    The KATRIN (KArlsruhe TRItium Neutrino) experiment will measure the endpoint region of the tritium β decay spectrum to determine the neutrino mass with a sensitivity of 200 meV/c{sup 2}. To achieve this sub-eV sensitivity the energy of the decay electrons will be analyzed using a MAC-E type spectrometer. The retarding potential of the MAC-E-filter (up to -35 kV) has to be monitored with a relative precision of 3 . 10{sup -6}. For this purpose the potential will be measured directly via two custom made precision high voltage dividers, which were developed and constructed in cooperation with the Physikalisch-Technische Bundesanstalt Braunschweig. In order to determine the absolute values and the stability of the scale factors of the voltage dividers, regular calibration measurements are essential. Such measurements have been performed during the last years using several different methods. The poster gives an overview of the methods and results of the calibration of the precision high voltage dividers.

  2. Ettevõtte edu sisse osta ei saa / Katrin Bats, Janne Laik, Silver Vohu, Evelin Ojamets ; intervjueerinud Küllike Heide

    Index Scriptorium Estoniae

    2012-01-01

    Kommunikatsiooni- ja turundustegevuse korraldusest ettevõtetes, mille suur osa antud projektidest hõlmab kõiki Balti riike. Mõtteid jagavad Katrin Bats Rimi Eesti Food AS-ist, Janne Laik NP Foods Eesti OÜ-st, Silver Vohu SEB Pangast ja Evelin Ojamets Coca-Cola-st

  3. Ultra-stable implanted 83Rb/83mKr electron sources for the energy scale monitoring in the KATRIN experiment

    CERN Document Server

    Zboril, M.; Beck, M.; Bonn, J.; Dragoun, O.; Jakubek, J.; Johnston, K.; Kovalik, A.; Otten, E.W.; Schlösser, K.; Slezak, M.; Spalek, A.; Thümmler, T.; Venos, D.; Zemlicka, J.; Weinheimer, C.

    2013-01-01

    The KATRIN experiment aims at the direct model-independent determination of the average electron neutrino mass via the measurement of the endpoint region of the tritium beta decay spectrum. The electron spectrometer of the MAC-E filter type is used, requiring very high stability of the electric filtering potential. This work proves the feasibility of implanted 83Rb/83mKr calibration electron sources which will be utilised in the additional monitor spectrometer sharing the high voltage with the main spectrometer of KATRIN. The source employs conversion electrons of 83mKr which is continuously generated by 83Rb. The K-32 conversion line (kinetic energy of 17.8 keV, natural line width of 2.7 eV) is shown to fulfill the KATRIN requirement of the relative energy stability of +/-1.6 ppm/month. The sources will serve as a standard tool for continuous monitoring of KATRIN's energy scale stability with sub-ppm precision. They may also be used in other applications where the precise conversion lines can be separated fr...

  4. Requirements on read-out electronics for future keV-scale sterile neutrino search with KATRIN

    Energy Technology Data Exchange (ETDEWEB)

    Dolde, Kai [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany)

    2016-07-01

    Recent publications show the great potential of the KATRIN (KArlsruhe TRItium Neutrino) experiment in the search for sterile neutrinos in the mass range of a few keV down to active-to-sterile mixing angles at least one order of magnitude smaller than current laboratory limits of sin{sup 2}θ < 10{sup -3}. In order to be sensitive to the tiny kink-like signature of sterile neutrinos in tritium beta decay, KATRIN requires a novel sophisticated detector and read-out system. Several silicon prototype detectors are under construction at the moment to explore the most suitable detector design for this purpose. The selection of appropriate read-out electronics is strongly triggered by the requirements of allowing only very small systematic uncertainties due to ADC Non-Linearities to reach the expected sensitivity. This talk investigates the impact of ADC Non-Linearities on the tritium beta decay spectrum, depending on the digitization method of analogue signals of a multi-pixel silicon detector, peak sensing or waveform digitization. The simulations show a higher achievable sensitivity using waveform digitizers and moreover strongly favor additional variable post-acceleration of the electrons to smear out the periodic structure of the ADC Non-Linearities.

  5. Isotopes for fundamental research 83mKr for KATRIN and 101Rh and 109Cd for XRD studies on planets

    International Nuclear Information System (INIS)

    Rasulbaev, Makhsud

    2011-01-01

    The feasibility of production of 83 Rb from liquid, natural Br at the Bonn Cyclotron was shown. Production of 83 Rb/ 83m Kr generators for KATRIN Collaboration was optimized. 83m Kr release from RbBr residue after the evaporation of the excess Br was studied. A possibility of 83 Rb implantation with 38 % efficiency was shown in the example of non-radioactive 85 Rb implantation. Production optimization of X-ray sources, 101 Rh and 109 Cd, for implementation in XRD analysis set-up at Technical University of Dresden was experimentally investigated at the Bonn Cyclotron. (orig.)

  6. Isotopes for fundamental research {sup 83m}Kr for KATRIN and {sup 101}Rh and {sup 109}Cd for XRD studies on planets

    Energy Technology Data Exchange (ETDEWEB)

    Rasulbaev, Makhsud

    2011-12-16

    The feasibility of production of {sup 83}Rb from liquid, natural Br at the Bonn Cyclotron was shown. Production of {sup 83}Rb/{sup 83m}Kr generators for KATRIN Collaboration was optimized. {sup 83m}Kr release from RbBr residue after the evaporation of the excess Br was studied. A possibility of {sup 83}Rb implantation with 38 % efficiency was shown in the example of non-radioactive {sup 85}Rb implantation. Production optimization of X-ray sources, {sup 101}Rh and {sup 109}Cd, for implementation in XRD analysis set-up at Technical University of Dresden was experimentally investigated at the Bonn Cyclotron. (orig.)

  7. Monitoring the energy scale of KATRIN with conversion electrons of a solid {sup 83m}Kr source as nuclear standard

    Energy Technology Data Exchange (ETDEWEB)

    Schloesser, Klaus [IKP, Karlsruher Institut fuer Technologie (Germany); Collaboration: KATRIN-Collaboration

    2016-07-01

    For KATRIN to be able to achieve the desired sensitivity of 200 meV/c{sup 2} for the effective electron neutrino mass, it is of crucial importance that the energy scale of the main spectrometer (18.6 keV) is under control within +/-60 mV at any given time over the planned measurement time of approximately 5 years. Besides conventional high voltage dividers and high precision volt meters, a nuclear standard will be deployed additionally in a separate spectrometer of MAC-E filter type. The filter electrodes of both spectrometers are connected galvanically. For permanent and continuous monitoring an easy to use ion implanted source containing the noble gas {sup 83m}Kr was developed and qualified for HV monitoring at the ppm level in the 30 kV regime. This talk presents the methods applied and the achievements made.

  8. Constituents in oil field produced waters discharged into the Loch Katrine wetland complex, Park County, Wyoming, and their bioconcentration in the aquatic bird food chain

    International Nuclear Information System (INIS)

    Ramirez, P. Jr.

    1993-01-01

    Trace elements, hydrocarbons and radium-226 concentrations were analyzed in water, sediment and biota from the Loch Katrine wetlands at Park County, WY in 1992. This study was designed to determine if produced waters pose a risk to aquatic birds inhabiting the wetlands. The radium-226 concentration recorded at the Sidney Battery Discharge in July, 93.7 pCi/l, exceeded WY DEQ's 60 pCi/l standard for the protection of aquatic life. Water quality acute criteria were exceeded for arsenic, Custer Lake, July, and for zinc, Sidney Battery discharge, April. Radium-226 concentrations in sediments from Custer Lake and Sidney Battery Discharge exceeded the 3 pCi/g background for Oregon Basin soils. The radium-226 concentration in aquatic vegetation, Custer Lake, 29.5 pCi/g, greatly exceeded the 2.9 pCi/g average concentration found in plants growing in uranium mill tailings in South Dakota. Radium-226 in aquatic vegetation may be available to aquatic birds. Oil and grease concentrations, Sidney Battery Discharge, exceeded the 10 mg/l standard of WY DEQ. Sediment hydrocarbon concentrations were highest at Sidney Battery Discharge, 6.376 μg/g, followed by Custer Lake, 1.104 μg/g. Benzo(a)pyrene was not detected in gadwalls from Loch Katrine but was detected in northern shovelers from Custer Lake. Benzo(a)pyrene concentrations in northern shoveler bile ranged from 500 to 960 ng/g (ppb) wet weight. Benzo(a)pyrene concentrations in shovelers is indicative of exposure to petroleum hydrocarbons

  9. Background reduction of the KATRIN spectrometers. Transmission function of the pre-spectrometer and systematic tests of the main-spectrometer wire electrode

    Energy Technology Data Exchange (ETDEWEB)

    Prall, Matthias

    2011-07-04

    The KArlsruhe TRItium Neutrino experiment, KATRIN will determine the mass of the anti {nu}{sub e} with a sensitivity of 0.2 eV (90% C.L.) via a measurement of the {beta}-spectrum of tritium decaying in a windowless gaseous molecular tritium source near its endpoint of 18.57 keV. This approach relies exclusively on the relativistic kinematics of the decay products rendering the experiment model independent and reducing the systematic uncertainty. An ultra-low background of a few mHz and an energy resolution of 0.93 eV are among the requirements to reach the sensitivity. These demands are fulfilled with the main spectrometer (MS). While the {beta}-decay electrons are guided by a magnetic field through the experiment, the MS acts as a high-pass filter for the {beta}-decay electrons. Only those above an energy barrier, the retarding potential, are transmitted to the detector. The last about 30 eV of the T{sub 2} {beta}-spectrum will be scanned in this way. The MS is equipped with a 650 m{sup 2}, two-layered, UHV compatible and quasi-massless wire electrode suppressing secondary electron background originating at the main-spectrometer walls and caused by residual radioactivity and cosmic muons. Its energy resolution of 0.93 eV is only achieved, if a large part of the 248 wire electrode modules, which determine the electric field inside the MS, has a mechanical precision of 0.2 mm. Not a single of the about 28.000 wires of the electrode must break during the lifetime of KATRIN. A 2-dimensional laser sensor for contact-less position (precision about 0.01 mm) and tension (precision about 0.04 N) measurements was developed and applied, to firstly, verify the mechanical precision of the electrode modules and secondly, to examine their reliability. A 3-dimensional coordinate measurement table was automated to perform these measurements in a clean room. This table was also used to verify the precision of components using a camera system and image recognition methods (0.05 mm

  10. Rock kinoekraanil / Katrin Rajasaare

    Index Scriptorium Estoniae

    Rajasaare, Katrin

    2008-01-01

    7.-11. juulini kinos Sõprus toimuval filminädalal "Rock On Screen" ekraanile jõudvatest rockmuusikuid portreteerivatest filmidest "Lou Reed's Berlin", "The Future Is Unwritten: Joe Strummer", "Control: Joy Division", "Hurriganes", "Shlaager"

  11. Biennaalitsirkus, biennaalileib / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2007-01-01

    52. Veneetsia biennaalist. Eesti paviljonis esineb Marko Mäetamm näitusega "I love my family". Lähemalt prantsuse kunstniku Sophie Calle ja inglise kunstniku Tracey Emini töödest. Hiina kunstnike Yang Fudongi filmist "Seitse intellektuaali bambusmetsas" ja Yang Zhenzhongi videoinstallatsioonist "I Will Die"

  12. Katrin Denev pokazala harakter

    Index Scriptorium Estoniae

    2006-01-01

    Veneetsia 63. filmifestivali auhinnatutest, kellest vaid Stephen Frears'i filmis "Kuninganna" ("The Queen") peaosa kehastanud Helen Mirren oli üks favoriitidest. Parima filmi peaauhind Kuldlõvi läks üllatuslikult Hiina režissööri Jia Zhang-Ke filmile "Vaikelu" ("Dong"). Ka teistest Veneetsia 63. filmifestivali võitjatest. Festivali žüriid juhatas Catherine Deneuve

  13. Naiste maailm / Katrin Rajasaare

    Index Scriptorium Estoniae

    Rajasaare, Katrin

    2001-01-01

    Pimedate Ööde V filmifestivalil näidatavast kolmest mängufilmist : Stefan Jägeri "Sünnipäev", Saksamaa 2001; Catherine Corsini "Proov", Prantsusmaa 2001; Rakhsan Bani Etemad "Linna kesta all", Iraan 2001

  14. Teistmoodi pulmafotod / Katrin Ruus

    Index Scriptorium Estoniae

    Ruus, Katrin

    2009-01-01

    Traditsioonilistest ja ebatraditsioonilistest tähtpäevafotodest. Dmitri Kotjuhi pildistatud pulmafotodest, kus on katsetatud erinevate keskkondadega. Tema fotosid on eksponeeritud näitusel "Argipäeva hetked"

  15. EITSA teatab / Katrin Pink

    Index Scriptorium Estoniae

    Pink, Katrin

    2005-01-01

    Eesti Infotehnoloogia Sihtasutuse konkursist "Mobiilsustoetused - ITK erialade doktorantide mobiilsus", mille eesmärgiks on toetada Eesti avalik-õiguslike ülikoolide info- ja kommunikatsioonitehnoloogia erialade doktorantide osavõttu erialastest konverentsidest, täienduskursustest, suve- ja talvekoolidest välisriikides

  16. Kas meediatsirkus? / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2006-01-01

    Turner Prize'i 2006. a. kunstipreemia näitusest Londonis Tate-Britainis. Nominente oli neli: Tomma Abts, Mark Titchner, Phil Collins ja Rebecca Warren. Preemia pälvis saksa-inglise maalikunstnik Tomma Abts. Pikemalt Phil Collinsi videost "Reaalse naasmine"

  17. Barcelona Biennaalid / Katrin Koov

    Index Scriptorium Estoniae

    Koov, Katrin, 1973-

    2006-01-01

    Euroopa maastikuarhitektuuri biennaalist teemal "Landscape: a product - a production". 2003. a. Rosa Barba eripreemia pälvis laviinitõke Islandil (Reynir Vilhjalmsson), 2006. a. võidutööd: Pedra Tosca park Gironas (RCR Arhitektid), tööstusmaastikule loodud park-märgala (David Verport). Euroopa avaliku linnaruumi preemia konkursist võtsid esmakordselt osa eestlased nelja tööga (Rakvere keskväljak, Tubina mälestusmärk Tartus, trepp Rakvere Vallimäele, KUMU kompleks). Võitsid Horvaatia töö Morske Orgulje (Zadar), arhitekt Nikola Basic ja Hollandi töö A8ernA (Zaanstad), autor NL Architects

  18. keV-Scale sterile neutrino sensitivity estimation with time-of-flight spectroscopy in KATRIN using self-consistent approximate Monte Carlo

    Science.gov (United States)

    Steinbrink, Nicholas M. N.; Behrens, Jan D.; Mertens, Susanne; Ranitzsch, Philipp C.-O.; Weinheimer, Christian

    2018-03-01

    We investigate the sensitivity of the Karlsruhe Tritium Neutrino Experiment (KATRIN) to keV-scale sterile neutrinos, which are promising dark matter candidates. Since the active-sterile mixing would lead to a second component in the tritium β-spectrum with a weak relative intensity of order sin ^2θ ≲ 10^{-6}, additional experimental strategies are required to extract this small signature and to eliminate systematics. A possible strategy is to run the experiment in an alternative time-of-flight (TOF) mode, yielding differential TOF spectra in contrast to the integrating standard mode. In order to estimate the sensitivity from a reduced sample size, a new analysis method, called self-consistent approximate Monte Carlo (SCAMC), has been developed. The simulations show that an ideal TOF mode would be able to achieve a statistical sensitivity of sin ^2θ ˜ 5 × 10^{-9} at one σ , improving the standard mode by approximately a factor two. This relative benefit grows significantly if additional exemplary systematics are considered. A possible implementation of the TOF mode with existing hardware, called gated filtering, is investigated, which, however, comes at the price of a reduced average signal rate.

  19. CTNNA3 and SEMA3D

    DEFF Research Database (Denmark)

    McGeachie, Michael J; Wu, Ann C; Tse, Sze Man

    2015-01-01

    BACKGROUND: Asthma exacerbations are a major cause of morbidity and medical cost. OBJECTIVE: The objective of this study was to identify genetic predictors of exacerbations in asthmatic subjects. METHODS: We performed a genome-wide association study meta-analysis of acute asthma exacerbation in 2...

  20. Katrin Schütz: Geschlechterentwürfe im literarischen Werk von Lou Andreas-Salomé unter Berücksichtigung ihrer Geschlechtertheorie. Würzburg: Verlag Königshausen & Neumann 2008

    Directory of Open Access Journals (Sweden)

    Romana Weiershausen

    2009-03-01

    Full Text Available Katrin Schütz hat eine Studie zu Geschlechterkonzeptionen in Lou Andreas-Salomés Frühwerk vorgelegt, in der auch die bislang wenig berücksichtigten literarischen Texte der Autorin ausgewertet werden. Die Anlage zielt auf eine Überblicksdarstellung, hinter der die differenzierende Reflexion der einzelnen Thesen zurück steht: Schütz geht es um die Konturierung einer Typologie. Durch die erweiterte Textgrundlage wird dabei Neues erschlossen, woraus sich anregende Impulse für die Jahrhundertwende-Forschung ergeben.Katrin Schütz’s study of gender conceptions in Lou Andreas-Salomé’s early work considers those literary texts often ignored by scholarship. The study is constructed as an overview, in light of which a differentiated reflection on the individual theses falls short: Schütz intends to formulate a typology. The expanded textual basis allows for the creation of something new, which will in turn provide inspirational impulses for turn-of-the-century research.

  1. Pilk piiri taha / Katrin Talts

    Index Scriptorium Estoniae

    Talts, Katrin

    2004-01-01

    Lasteteatrite festivalist "Bravo", Sankt-Peterburgi Teatriakadeemia 225. aastapäeva pidustustest, XXVIII "Humana" festivalist, XVIII rahvusvahelisest koreograafiakonkursist Hannoveris, IX rahvusvahelisest tantsufestivalist "Steps" ja Rootsi tantsubiennaalist 2004

  2. "Private Views" Ungaris / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    1999-01-01

    Inglise ja eesti kunstnike ühisprojekt 8. augustini Dunaujvarosi Kaasaegse Kunsti Instituudis Ungaris. Kuraatorid Pam Skelton, Mare Tralla. "Private Views" ülesandeks on keskenduda ruumi mõistele naiskunstniku pilgu läbi

  3. 'Private Views' Ungaris / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    1999-01-01

    Inglise js eesti kunstnike ühisprojekt 8. augustini Dunaujvarosi Kaasaegse Kunsti Instituudis Ungaris. Kuraatorid Pam Skelton, Mare Tralla. 'Private Views' ülesandeks on keskenduda ruumi mõistele naiskunstniku pilgu läbi.

  4. Lapsed ja digikultuur / Katrin Kuusik

    Index Scriptorium Estoniae

    Kuusik, Katrin

    2015-01-01

    Vestlusest TLÜ BFMi koolitusjuhi ja laste filmikooli juhendajaga tema poolt laste ja õpetajatega läbi viidud hariduslikest projektidest, mille eesmärgiks on tutvustada ja rakendada erinevaid filmi ja animatsiooni nippe koolitöös

  5. Raamatu teekond Euroopas / Katrin Kaugver

    Index Scriptorium Estoniae

    Kaugver, Katrin, 1950-

    2006-01-01

    Esimese Eesti raamatukoguna sai TLÜ AR Euroopa Teadusraamatukogude Konsortsiumi (CERL) täisliikmeks. CERL kogub, haldab ja levitab informatsiooni Euroopa varajase trükitud kultuuripärandi kohta. Täisliikme staatus annab raamatukogule lugejatele juurdepääsu andmebaasile HPB (Hand Press Book Database)

  6. Teatrimaailm / Mari Kolle, Katrin Talts

    Index Scriptorium Estoniae

    Kolle, Mari

    2005-01-01

    23. märtsil avatakse unikaalne interneti-projekt "Cultu.Ru!" ; Londoni Criterion Theatre'is etendub "Amajuba. Me tõuseme lendu nagu tuvid", mida esitavad Lõuna-Aafrika viis näitlejat, kes räägivad oma elust ; ITI on tänavu ülemaailmse teatripäeva pühendanud naistele, korraldades rahvusvahelise kübernäituse "Naised teatris", mis esitleb eri maade teatripraktikuid : naislavastajaid, näitekirjanikke ja näitlejannasid XX sajandi II poolel ; Pariisis tegutsevast Päikeseteatrist ning teatri asutajast ja juhist A. Mnouchkine'ist

  7. Näitused / Katrin Kurik

    Index Scriptorium Estoniae

    Kurik, Katrin

    1998-01-01

    Linnagalerii Tallinnas: Anna Pauli tekstiilid ja Andras Huberi skulptuurid (Ungari); Kullo lastegalerii: Heli Männi ja Tondiraba keskkooli kunstiklasside õpilaste "Veneetsia maskid"; Tammsaare majamuuseum: Kersti Karu keraamika

  8. Parimate teenindusraamatute otsinguil / Katrin Aedma

    Index Scriptorium Estoniae

    Aedma, Katrin

    2007-01-01

    Klienditeenindus ning kuidas seda arendada. Tabel: Johari aken. Teenindusraamatute tutvustus: Lars-Olof NΜssén "Parem teenindamine. Kuidas enesearenduse kaudu saavutada klientide rahulolu"; Malle Karjatse "Miks klient rahul ei ole? Kuidas meeldida eesti kliendile"

  9. "Puuduvate ajalugude" kirjutamisest / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2008-01-01

    Arvustus: Baigell, Renee. Baigell, Matthew. Peeling potatoes, painting pictures : women artists in post-Soviet Russia, Estonia, and Latvia : the first decade. New Brunswick : Rutgers University Press, 2001

  10. Vaikne torm Barcelonas / Katrin Koov

    Index Scriptorium Estoniae

    Koov, Katrin, 1973-

    2009-01-01

    2008. a. sügisel Barcelonas toimunud 5. Euroopa maastikuarhitektuuri biennaalist "Torm ja tung", sümpoosionist. Rosa Barba nimelise võistluse peaauhinna võitis Kristine Jenseni büroo Taanist projektiga "Nicolai". Auhinnavõistlusel ja valitud tööde näitusel esindas Eestit Tallinna Harju tänava park

  11. Bioenergia tootmise majandusmudelid / Katrin Heinsoo

    Index Scriptorium Estoniae

    Heinsoo, Katrin, 1962-

    2012-01-01

    Euroopa Liidus algatatud projekti "Bioenergia talu arendusplaan" eesmärk on anda talunikele ja väikeettevõtjatele struktuurset ja erapooletut informatsiooni bioenergia ja biokütuste tootmisest ja kasutamisest

  12. Pilk piiri taha / Katrin Talts

    Index Scriptorium Estoniae

    Talts, Katrin

    2004-01-01

    Rahvusvahelistest teatri- ja tantsufestivalidest - Hollandi tantsufestivalist "Springdance", Doonau festivalist Austrias, Taani lasteteatrite festivalist, kaunite kunstide festivalist "Kunstenfestival des Arts" Brüsselis, Vilniuse rahvusvahelisest tantsufestivalist "New Baltic Dance", teatrifestivalist "Theatertreffen Berlin", Vilniuse teatrifestivalist "New Drama in Action" ja poola teatrifestivalist "Kontakt"

  13. Pilk piiri taha / Katrin Talts

    Index Scriptorium Estoniae

    Talts, Katrin

    2004-01-01

    Rahvusvahelistest festivalidest - Londoni rahvusvaheline miimifestival, IV rahvusvaheline naiste teatrifestival ja -kohtumine, tantsufestival "British Dance Edition 2004", Euroopa lasteteatrite festival "Panoptikum", kus Eestit on kutsutud esindama VAT Teater lavastusega " Lend üle ookeani" -, Belgia tantsukooli PARTS eelvoorust Tallinnas, "Latvian Showcase"'ist, kus tutvustatakse paremaid läti uuslavastusi ja Helsingis toimuvast ekspeditsioonist tundmatusse (loominguline retk Põhja- ja Baltimaade teatrirahvale)

  14. Armastus keha vastu / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    1999-01-01

    Peamiselt New Yorgis tegutseva ungari-ameerika kunstniku Orshi Drozdiku (s. 1946) töödest "Medical Erotica" (1984) ja "Manufacturing the Self, Body Self" (1984-93), mida eksponeeritakse ühtse installatsioonina ja kuuluvad Budapesti kaasaegse kunsti muuseumi ehk Ludwigi muuseumi püsiekspositsiooni

  15. Kes joonistab uue kunstilaine kaardi? / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2008-01-01

    Anders Härmi ja Hanno Soansi kureeritud näitusest "Uus laine. 21. sajandi eesti kunstnikud" Tallinna Kunstihoones ja Kunstihoone galeriis ning Non Grata kollektiivnäitusest "Uus laine. 20. sajandi kunst" Kultuuritehases Polymer

  16. Uus teater tuleb Aasiast / Katrin Nielsen

    Index Scriptorium Estoniae

    Nielsen, Katrin

    2007-01-01

    Soulius toimunud Aasia lasteteatrite festivalist "AssiFE 2007". Mõningatest lavastustest: Tõkyõ teater Kakashiza "Saabastega kass", Sadari teatri "Kui ta kell seisma jäi", Tuida teatri "Haruki lugu", Souli Joyful Theatre'i vendade Grimmide lugu konn-printsist, Shiny Shoes Theatre'i "Maagiline hõljuv laud", Ulgul Gwa Ulgul "Laul lameda näoga Kong-List"

  17. Inimene ja tema raamat / Katrin Kaugver

    Index Scriptorium Estoniae

    Kaugver, Katrin, 1950-

    2008-01-01

    Rets. rmt.: Omanikumärgid vanaraamatus : artiklite kogumik = Ownership marks in old books : collection of articles = Владельческий знак на старинной книге : сборник статей / Eesti Rahvusraamatukogu ; koostaja ja toimetaja Larissa Petina. Tallinn : Eesti Rahvusraamatukogu, 2008

  18. Pidulikult Kaiu vallast / Katrin Helend-Aaviku

    Index Scriptorium Estoniae

    Helend-Aaviku, Katrin

    2009-01-01

    20. veebruaril Kuimetsa rahvamajas pidulikul Eesti Vabariigi 91. aastapäevale pühendatud austamis- ja õnnitlemisõhtul jagati tänu Kaiu valla aasta tegijatele tänukirjade, preemiate ja aunimetustega. Elutöö preemia pälvis Elju Praats, aasta kultuuriedendajaks tunnistai Siiri Sisask, preemia "Kaunis kodu 2008" sai Kaari Küün

  19. Metsaserva funktsionalistlik saunamaja / Jaan Port, Katrin Kaevats

    Index Scriptorium Estoniae

    Port, Jaan

    2006-01-01

    Autorid tutvustavad 2006. a. valminud Pintsonite perekonna saunsuvilat Lohusalus. Projekteerimisest, ruumiprogrammist, materjalidest. Ill.: joon.: I ja II korruse plaan, 4 vaadet, 6 värv. fotot: 3 välis- ja 3 sisevaadet

  20. Euroopa Liidu IT-agentuur / Katrin Koov

    Index Scriptorium Estoniae

    Koov, Katrin, 1973-

    2015-01-01

    Arhitektuurivõistluse eesmärk oli leida Euroopa Liidu IT-agentuuri peahoone rajamiseks Vesilennuki tänavale Tallinnas parim arhitektuuriline lahendus. Esitati 15 ideekavandit, millest kvalfitseerusid 14. Esimese koha sai töö märgusõnaga "Turing" (autorid: Jaan Kuusemets, Üllar Ambos, Pille Noole, Ioannis Lykouras, Erko Luhaaru, DAGOpen ja LÜNK Arhitektid). Teisele kohale tuli töö märgusõnaga "Platoo" (autor Karli Luik, AB Kontekst). Kolmandale kohale tuli töö märgusõnaga "Bastion" (autorid: Ralf Lõoke, Maarja Kask, Martin McLean, Salto AB).

  1. Traditsioonist ja uuendusest korea modernkunstis / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2005-01-01

    Souli galeriides ja muuseumides valitseb eeldatud kõrgtehnoloogilise kunsti asemel maalikunst. Pikemalt naiskunstnik Wook-kyung Choi (1940-1985) ja Jong-gu Lee näitustest ning soo- ja naisuuringute kongressist "Women's World 2005"

  2. USA suursaadikuga Tallinna lahel / Katrin Kruss

    Index Scriptorium Estoniae

    Kruss, Katrin

    2007-01-01

    USA suursaadik Stanley Davis Phillips oma haridusteest, perekonnast, armastusest mere vastu, panusest isa Earl Phillipsi mööbliäri laiendamisse, golfiharrastusest, suursaadikute ettevalmistusest USA-s, suursaadiku residentsist Pirital ning uue saatkonnahoone otsingutest Tallinnas. Lisa: Stanley Davis Phillips

  3. Vene teatri mitu palet / Katrin Talts

    Index Scriptorium Estoniae

    Talts, Katrin

    2003-01-01

    27. märtsist 14. aprillini toimus Sankt-Peterburgis iga-aastane teatrifestival "Kuldne mask". Festivali parimaks lavastuseks tunnistati L. Petrushevskaja "Moskva koor" I. Konjajevi lavastuses, lavastajapreemia pälvis K. Ginkas lavastusega "Daam koerakesega"

  4. Vali õige elukutse tundes iseennast / Katrin Kaurit

    Index Scriptorium Estoniae

    Kaurit, Katrin

    2002-01-01

    Kutsevalik ja õigete eesmärkide saavutamine eeldab oma võimete, tugevuste ja arendamist vajavate külgede analüüsimist. Abivahendiks sel puhul on DiSC (Personal Profile System) analüüsimetoodika, mille kaudu selgitatakse välja inimese peamised käitumisavaldused ja arendamist vajavad küljed

  5. Inglise keele õppekomplekt lastele / Katrin Tariq

    Index Scriptorium Estoniae

    Tariq, Katrin

    2001-01-01

    4-10-aastaste laste inglise keele õppekomplekti kuuluvad : piltsõnastik, töövihik, sõnakaardid, plakatid, lauamäng, mänguasjad. Rets. : Müürsepp, Mare. My home, family and friends. - Tallinn : TEA Kirjastus, 2001

  6. Lojaalsed kliendid ja suhete loomine / Katrin Aedma

    Index Scriptorium Estoniae

    Aedma, Katrin

    2007-01-01

    Teenindust käsitlevate raamatute tutvustus. Seth Godini "Nõusolekuturundus: kuidas muuta võõraid sõpradeks ja sõpru klientideks", Kaj Storbacka ja Jarmo R. Lehtineni "Klientsuse reeglid või tants klientide pilli järgi" ja Frederick F. Reichheldi "Lojaalsuse reeglid. Kuidas edukad juhid loovad kestvaid töö- ja kliendisuhteid". Lisad: Eksimused ja surmapatud teeninduses!; Sellest, mida sa tead, pole kasu, kui sa seda ei kasuta!

  7. Uurimist toimetavad Wolfe ja Goodwin / Katrin Mõttus

    Index Scriptorium Estoniae

    Mõttus, Katrin

    2003-01-01

    Sari filme - Rex Stout'i detektiivromaanide ekraniseeringud, kus peategelaseks eradetektiiv Nero Wolfe (Maury Chaykin) koos oma noore abilise Archie Goodwiniga (Timothy Hutton) : Ameerika Ühendriigid 2001-2002

  8. Hea teater lastele ja noortele / Katrin Ruus

    Index Scriptorium Estoniae

    Ruus, Katrin

    2006-01-01

    22.-27. maini Tallinnas, Tartus, Pärnus, Narvas toimunud laste- ja noortetatrite festivalist "Draamake 2006". Nimetatud auhinnasaajad : lastelavastuse auhinna sai Vanemuise "Suur kuri hunt" (lavastaja Taago Tubin), noorsooteatri auhind määrati Vene Teatri lavastusele "Veerevad kivid ei sammaldu" (lavastaja Nikita Grinshpun), näitlejaauhinnaga pärjati Marika Vaarikut osatäitmise eest VAT Teatri lavastuses "Klammi sõda", publikupuudutuse auhinna sai ZUGA ühendatud tantsijate "ZUGA lastekas" ja sõnajõuauhind läks NO99 teatri lavastusele "Kaks päikest" (lavastaja Andres Noormets)

  9. Plaadid / Katrin Malt, Virko Pirrus, Mart Kalvet

    Index Scriptorium Estoniae

    Malt, Katrin

    2008-01-01

    Uutest heliplaatidest Atrocity "Werk 80 II", Benighted "Icon", Brain Drill "Apocalyptic Feasting", BrainStorm "Downburst", Diablo Swing Orchestra "The Butcher's Ballroom", Floodstain "Dreams Make Monters", Foxy Shazam "Introducting Foxy Shazam"

  10. Kaameraga taldrikusse ja kaugemale / Katrin Press

    Index Scriptorium Estoniae

    Press, Katrin

    2016-01-01

    Taani väikelinnas Vejles 2015. aasta sügisel toimunud rahvusvahelisest toidufotofestivalist, mis ühendas fotokonkursi, seminarid, töötoad, näitused ja võimaluse kolleegide seltsis aega veeta ning omavahel tuttavaks saada

  11. Viisakus ja selle tajumine tekstiliigiti / Katrin Rikberg

    Index Scriptorium Estoniae

    Rikberg, Katrin

    2009-01-01

    Artikkel tutvustab keelesuhtluse viisakuse kultuuriomaseid mõisteid ja nende seoseid asjakohasusega ning keskendub ametlikule viisakusele ja vestluskäitumisele. Küsimustiku abil läbi viidud taju-uuringust, mille eesmärk oli võrrelda tekstide vastuvõtu erinevaid külgi, et saada teada, mida ja miks peetakse eesti kultuuriruumis viisakaks ja asjakohaseks

  12. Tänavast. Sotsiaalselt / Katrin Koov

    Index Scriptorium Estoniae

    Koov, Katrin, 1973-

    2010-01-01

    22.-23. septembril 2010 toimunud Eesti Kunstiakadeemia 7. urbanistika ja linnamaastiku päevade 2. osast, rahvusvahelisest konverentsist "Sotsiaalne tänav". Peaesinejad: Lars Gemzøe (Taani), Dago Antov, Sabine Knierbein (Austria), Zane Bērziņa (Läti/Saksamaa). Lisaprogrammis näidati arhitektuuriüliõpilaste poolt rahvusvahelise workshop'i CinemArchitecture raames tehtud linnateemalisi lühifilme

  13. Naised, kes teevad suurt raha / Katrin Kapara

    Index Scriptorium Estoniae

    Kapara, Katrin

    2008-01-01

    Maailma rikkaimate inimeste edetabelit koostava ajakirja Forbes nimestikus oli tänavu 99 naist. Liliane Bettencourt - kosmeetikaimpeeriumi LþOreal pärija, Zhang Xin - firma SOHO China omanik, Cristina Green - jaekaubanduskettide omanik, Jelena Baturina - Vene ärinaine, Meg Whitman - eBay käivitaja, Oprah Winfrey - Ameerika telesaatejuht

  14. Gaseous Kr-83m generator for KATRIN

    Czech Academy of Sciences Publication Activity Database

    Sentkerestiová, Jana; Dragoun, Otokar; Lebeda, Ondřej; Ryšavý, Miloš; Sturm, M.; Vénos, Drahoslav

    2018-01-01

    Roč. 13, č. 4 (2018), č. článku P04018. ISSN 1748-0221 R&D Projects: GA MŠk LTT18021; GA MŠk LM2015056 Institutional support: RVO:61389005 Keywords : detector alignment and calibration methods * instrument optimisation * spectrometers Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders OBOR OECD: Nuclear physics Impact factor: 1.220, year: 2016

  15. Globaliseerumine ja uued piirid / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    1999-01-01

    Viinis jaanuaris toimunud konverentsist "Translocation ئ (new) media/art", millega kaasnes meediakunsti näitus Viinis General Foundationi ruumides. Kaasaegse kunsti ajakirjade "Springerin" (Viin), "Detail" (Praha) ja "Magazin Sztuki" (Gdansk) pikem koostööprojekt translocation keskendub küsimusele, kuidas toimib uus meedia (kunst) "uues Euroopas". Eestit puudutava ettekandega esines K. Kivimaa.

  16. [Mati Erelt. Estonian Language] / Katrin Hiietamm

    Index Scriptorium Estoniae

    Hiietamm, Katrin

    2004-01-01

    Arvustus: Estonian language / [Estonian Academy of Sciences] ; edited by Mati Erelt.Tallinn : Teaduste Akadeemia Kirjastus, 2003. 412, [1] lk. : ill., kaart. (Linguistica Uralica. Supplementary series, 0868-4731 ; vol. 1)

  17. President viidi erilennukiga lennukikandjat uudistama / Katrin Rohtla

    Index Scriptorium Estoniae

    Rohtla, Katrin, 1966-

    2007-01-01

    President Toomas Hendrik Ilves lendas ameeriklaste organiseeritud lennuga Sitsiiliasse, et sealt sõita erilennuki pardal USA lennukikandjale USS Enterprise. Koos presidendiga käisid lennukikandjat uurimas Riigikogu esimees Ene Ergma ja Riigikogu liige Mati Raidma

  18. Linn - sajandi suur armastus / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2001-01-01

    Tate Modern'is avatud näitusest "Sajandi linn : kunst ja kultuur modernses metropolis". Pariisi, Viini, Moskva, Lagose, Rio de Janeiro, Tokyo, New Yorgi, Londoni ja Bombay väljapanekutest. Järgneb 20. apr. 2002, lk. 8

  19. Valgussähvatused saalipimedusest / Katrin Rajasaare

    Index Scriptorium Estoniae

    Rajasaare, Katrin

    2002-01-01

    6. Pimedate Ööde Festivali filmidest : "Puur" ("La Cage"), režissöör Alain Raoust : Prantsusmaa 2002, "Kuuvalgel" ("Kuutamolla"), režissöör Aku Louhimies : Soome 2001, "Kaunis Martha" ("Bella Martha"), režissöör Sandra Nettelbeck : Saksamaa 2001

  20. Mis isiklik? Mis poliitiline? / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2010-01-01

    Saksa kunstniku Hannah Höchi näitus "Isiklik on poliitiline. Hannah Höch ja tema kunsti tõlgendus" Tallinna Kunstihoones 17. oktoobrini 2010, kuraator Reet Varblane. Ka näitusel eksponeeritud Martha Rosleri (USA), Guerrilla Girlsi (USA), Anna-Stina Treumundi (Eesti) töödest

  1. Kes joonistab uue kunstilaine kaardi? / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2007-01-01

    Eesti noorema kunsti näitus "Uus laine. 21. sajandi eesti kunstnikud" (kuraatorid Anders Härm, Hanno Soans) Tallinna Kunstihoones ja Kunstihoone galeriis. Non Grata kollektiivnäitus "Uus laine. 20. sajandi kunst" Kultuuritehases Polymer

  2. Monitoring Rural Water Points in Tanzania with Mobile Phones : The Evolution of the SEMA App

    NARCIS (Netherlands)

    Lemmens, R.L.G.; Lungo, J.; Georgiadou, P.Y.; Verplanke, J.J.

    2017-01-01

    Development professionals have deployed several mobile phone-based ICT (Information and Communications Technology) platforms in the global South for improving water, health, and education services. In this paper, we focus on a mobile phone-based ICT platform for water services, called Sensors,

  3. Kotler : edukate firmade juhid ei ole karismaatilised / Katrin Rohtla

    Index Scriptorium Estoniae

    Rohtla, Katrin, 1966-

    2007-01-01

    Ilmunud ka: Delovõje Vedomosti 6. juuni lk. 8. Turundusguru Philip Kotler rääkis Tallinnas konverentsil uutest müügi- ja turundusstrateegiatest. Vt. samas: Sirje Rank. Kotler tõstis esile turunduse väärtuse

  4. Tavaline turundus hääbub / Katrin Rohtla

    Index Scriptorium Estoniae

    Rohtla, Katrin, 1966-

    2007-01-01

    Tallinnas esinenud Philip Kotler ennustab, et traditsiooniline turundus on asendumas turundusega, mis eelistab suust suhu marketingi ja kuulujututurundust. Vt. samas: USA-s on kuulujututurundusest saanud elukutse; Kuulujututurunduseks sobivad tooted

  5. Toiduvilja koht pole kütusepaagis / Katrin Saks

    Index Scriptorium Estoniae

    Saks, Katrin, 1956-

    2008-01-01

    Ilmunud ka: Nädaline 22. mai, lk. 4, Pärnu Postimees 22. mai, lk. 15, Võrumaa Teataja 22. mai, lk. 2, Vooremaa 22. mai, lk. 2, Valgamaalane 22. mai lk. 2, Hiiu Leht 23. mai, lk. 2, Kuulutaja 23. mai lk. 4, Koit 24. mai lk. 6, Järva Teataja, Harju Elu 27. mai lk. 2, Vali Uudised 28. mai lk. 2, Meie Maa 29. mai lk. 2, Lääne Elu 5. juuni lk. 2, Virumaa Teataja 6. juuni, lk. 11, Sakala 6. juuni lk. 2, Molodjozh Estonii 9. juuni lk. 7. Euroopa Parlamendi liige annab ülevaate EL biokütusepoliitikast

  6. The model of Internet-based marketing communication / Katrin Kull

    Index Scriptorium Estoniae

    Kull, Katrin

    2004-01-01

    Turunduskommunikatsioon Interneti teel erineb traditsioonilisest turunduskommunikatsioonist, võimaldades sõnumite ja tagasiside liikumise protsessi kahesuunalisust ning muutes seega kogu turunduskommunikatsiooni õppimis-(või tundmaõppimis-)protsessiks. Skeemid. Tabelid

  7. Kes kardab poeete? / Giuseppe Provenzano ; tõlk. Katrin Tombak

    Index Scriptorium Estoniae

    Provenzano, Giuseppe

    2008-01-01

    Tallinna Harjumäele rajatavast Vabaduse monumendist, ummiku äärele jõudnud avalikust diskussioonist, monumendi tähendusest. Õnnestunud monument peab esmajoones puudutama meie hinge ja tal ei tohiks puududa ilu

  8. Alkoholitööstus : [2003 Eestis] / Katrin Karolin

    Index Scriptorium Estoniae

    Karolin, Katrin

    2004-01-01

    Ilmunud ka: Agriculture and rural development : overview 2003/2004. - Tallinn, 2004, lk. 104-118. Kangete alkohoolsete jookide tootmine suurenes 2003. a. Statistikaameti andmeil 16,4%, õlut toodeti 2003. a. 1% rohkem kui 2002. a. Tabelid. Diagrammid

  9. Prantsuse maastikuarhitektid Berliinist = French Landscape Architects from Berlin / Katrin Koov

    Index Scriptorium Estoniae

    Koov, Katrin, 1973-

    2003-01-01

    Berliinis töötavad prantsuse maastikuarhitektid Veronique Faucheur, Marc Pouzol ja Laurent Dugua büroost le balto kujundavad Tallinnasse "Heliose" kino hoovi valgusaia. Valminud on projekti I etapp, aed valmib 2004. a. kevadeks. Arhitektide loomingust (projekt "Ajutised Aiad" ja Kunst-Werke aed Berliinis, Palais de Tokyo aed Pariisis, Padula kloostri aed Itaalias)

  10. Eesti film 101. Organiseerumine versus loomingulisus? / Katrin Maimik

    Index Scriptorium Estoniae

    Maimik, Katrin, 1982-

    2012-01-01

    Tallinnas Maarjamäe lossis 7. juunil toimunud konverentsist "Eesti film 101, filmitööstuse tulevikuvisioonid" ja sellelel järgnenud ümarlauast teemal "Eesti filmivaldkonna organisatoorne kultuur"

  11. Lusikas nomaadidele / Riho Tiivel ; interv. Inna-Katrin Hein

    Index Scriptorium Estoniae

    Tiivel, Riho

    2005-01-01

    Eesti Kunstiakadeemia tootedisaini eriala üliõpilane Riho Tiivel võitis Itaalias toimunud disainikonkursi ReAL 13 "Eating Anywhere" peapreemia oma alumiiniumist lusikaga "Spoon Container". Riho Tiivel on lõpetanud Tartu Kunstikooli mööblirestaureerijana

  12. Projekti Min-E-Max kohtumine Saksamaal / Katrin Arge

    Index Scriptorium Estoniae

    Arge, Katrin

    2005-01-01

    Oktoobri keskel toimus Lõuna-Saksamaa väikelinnas Oberderdingenis Hispaania, Portugali, Ungari, Leedu, Eesti ja Saksamaa õpetajate kohtumine seoses Euroopa Liidu poolt rahastatava Comenius1 projektiga Min-E-Max (minimum energy input maximum output)

  13. ISEA näitused Tallinnas / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2004-01-01

    ISEA kunstiprojekte Tallinna eri näitusepaikades: Kunsthoone ja lähikond (M. Fairskye, N. Urboniene, G. Urbonas jt.), Tarbekunsti- ja disainimuuseum (K. Dobson, A. Rewakowicz), Rotermanni soolaladu (eestlaste duo I.D, L. Petrovich, S. Rigon jt.), teised kohad. Eestlasi esindab ISEA-l I. Kivi ja D. Kase (I.D.) installatsioon ning U. Puhkani ja L. Kiluski performance. Kunstihoone galeriis eesti meediakunsti retrospektiiv

  14. An angular-selective electron source for the KATRIN experiment

    Czech Academy of Sciences Publication Activity Database

    Beck, M.; Bokeloh, K.; Hein, H.; Bauer, S.; Baumeister, H.; Bonn, J.; Ortjohann, H.W.; Ostrick, B.; Rosendahl, S.; Streubel, S.; Valerius, K.; Zbořil, Miroslav; Weinheimer, C.

    2014-01-01

    Roč. 9, č. 11 (2014), č. článku 11020. ISSN 1748-0221 R&D Projects: GA ČR(CZ) GAP203/12/1896 Institutional support: RVO:61389005 Keywords : spectrometers * photoemission * detector alignment and calibration methods Subject RIV: BF - Elementary Particles and High Energy Physics OBOR OECD: Particles and field physics Impact factor: 1.399, year: 2014

  15. Kodumaiselt rahvusvaheline filmifestival. 6. Sleepwalkers' tudengifilmide festival / Katrin Rajasaare

    Index Scriptorium Estoniae

    Rajasaare, Katrin

    2006-01-01

    IX Pimedate Ööde Filmifestivali alafestivali Sleepwalkers' Student Film Festivali tudengifilmidest : eesti filmid ja auhinnatud filmid - peaauhind rootslase Axel Danielsoni "Suvepilved" ("Sommarlek"), eriauhinnad eestlase Ekke Vasli "Nagu ikka", Saksamaa austraallase Jack Rothi "Olli", korealase Chansoo Kimi "Vaudeville"

  16. "Salatoimikud" Indiana Jonesi moodi / Inna-Katrin Hein

    Index Scriptorium Estoniae

    Hein, Inna-Katrin

    2008-01-01

    Steven Spielbergi neljas Indiana Jones'i film Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") : Ameerika Ühendriigid 2008

  17. Mis on see meie oma meediaruum? / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    1999-01-01

    Meediakunsti festivali 'Interstanding 3' raames toimunud konverents 'Ülalpool piire'. Kuraator Eric Kluitenbergi, peaesineja sotsioloogiaprofessor Saskia Sasseni, bulgaaria kunstniku Luchezar Boyadjievi esinemisest. Eesti ja internet

  18. "Siin me oleme" staarid paljastasid Muhumaal saladusi / Katrin Pauts

    Index Scriptorium Estoniae

    Pauts, Katrin, 1977-

    2002-01-01

    Sulev Nõmmiku populaarse komöödiafilmi "Siin me oleme" (Eesti Telefilm 1978) osatäitjad Lia Laats, Kadri Jäätma, Väino Puura ja Imre Sooäär meenutasid Pädaste mõisas kokku tulles filmimise rõõme ja muresid

  19. Sundosaõigus ja tagasivõitmine / Katrin Sepp

    Index Scriptorium Estoniae

    Sepp, Katrin

    2017-01-01

    Sundosa mõistest ja sundosa saajatest. Sihtasutusse paigutatud vara arvesse võtmisest sundosa suuruse määramisel, sundosaõigusest tulenevatest nõudetest sihtasutuse vastu ja rahvusvahelistest pärimisasjadest

  20. First transmission of electrons and ions through the KATRIN beamline

    Czech Academy of Sciences Publication Activity Database

    Arenz, M.; Dragoun, Otokar; Kovalík, Alojz; Lebeda, Ondřej; Ryšavý, Miloš; Sentkerestiová, Jana; Suchopár, Martin; Vénos, Drahoslav

    2018-01-01

    Roč. 13, č. 4 (2018), č. článku P04020. ISSN 1748-0221 R&D Projects: GA MŠk LM2015056; GA MŠk LTT18021 Institutional support: RVO:61389005 Keywords : ion sources * electron beam * detector control systems * beam-line instrumentation * spectrometers Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders OBOR OECD: Nuclear physics Impact factor: 1.220, year: 2016

  1. Vandenõu Läänemerel / Katrin Laur

    Index Scriptorium Estoniae

    Laur, Katrin

    2003-01-01

    Saksamaal esilinastus poliitiline põnevusfilm "Balti torm" ("Baltic Storm"), mis kujutab parvlaev "Estonia" hukku venelaste vandenõu tulemusena. Produtsendid on Jutta Rabe, Kaj Holmberg ja Birgit Stein, režissöör ja üks stsenariste Reuben Leder, peaosades Greta Scacchi ja Jürgen Prochnow. Filmi vaieldavast konteptsioonist ja vastukajadest

  2. Varakambri lahtine värav / Katrin Kaugver

    Index Scriptorium Estoniae

    Kaugver, Katrin, 1950-

    2008-01-01

    Uppsalas toimunud CERL-i (Consortium of European Research Libraries) vanaraamatu seminar "Käsikiri, trükis ja internet", kus TLÜ professor Tiiu Reimo andis ülevaate meie raamatukogude ja arhiivide vanatrükiste kogudest

  3. Rünnak vaatemängu ajastule / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2000-01-01

    Rahvusvaheline videokunsti ja uue meedia festival "Video Positive 2000" Liverpoolis üldteemal "The Other Side of Zero". Kontseptsiooni autor Steven Bode. Pikemalt sotsiaalsetest projektidest Internetis ja Iliyana Nedkova kureeritud näitusest "Spacecraft", kus oli väljas ka Mare Tralla töö "silm-vaatlusõhupall"

  4. Ebavõrdsus hukutab Eesti arengu / Katrin Saks

    Index Scriptorium Estoniae

    Saks, Katrin, 1956-

    2004-01-01

    Ilmunud ka: Pärnu Postimees, 22. jaan. 2004, lk. 11; Võrumaa Teataja, 24. jaan. 2004, lk. 2; Meie Maa, 24. jaan. 2004, lk. 2; Hiiu Leht, 27. jaan. 2004, lk. 2; Põhjarannik, 31. jaan. 2004, lk. 2; Severnoje Poberezhje, 31. jaan. 2004, lk. 2; Koit, 3. veebr. 2004, lk. 6; Hiiumaa, 3. veebr. 2004, lk. 2. Autor vaatleb riigi osa ebavõrduse ilmingute likvideerimisel Eestis ja leiab, et ebavõrdsus on meie arengu peamine takistus, mille kõrvaldamine on sotsiaaldemokraatide peamine eesmärk

  5. Europa Cinemas auhindas Sõpruse kino / Katrin Rajasaare ; interv. Annika Koppel

    Index Scriptorium Estoniae

    Rajasaare, Katrin

    2005-01-01

    Euroopa ja Vahemere regiooni kinopidajaid ühendav organisatsioon Europa Cinemas kuulutas Sõpruse kino aasta parimaks noorsooürituste korraldamise kategoorias. Oma tööst räägib Sõpruse juht, kes käis ka 18. nov. Budapestis auhinda vastu võtmas

  6. Dialoogid kohatusest / Justin Ions ; tõlkinud Katrin Kivimaa

    Index Scriptorium Estoniae

    Ions, Justin

    2009-01-01

    Rahvusvaheline näitus "thisPLACEd" ("Kohatute koht") Tallinna Linnagaleriis 1. märtsini. Kuraatorid Silvina Der-Meguerditchian ja Reet Varblane. Suur osa näitusel osalevatest kunstnikest on armeenia päritolu. Koostöösse on kaasatud Eestiga seotud kunstnikud Olga Jürgenson (elab Londonis) ja Eléonore de Montesquiou

  7. Naised, kes toovad naeratuse näole / Katrin Oja

    Index Scriptorium Estoniae

    Oja, Katrin

    2006-01-01

    Heast teenindusest räägivad Eesti Gaasi juhatuse esimehe assistent, Aasta Sekretär 2005 Tiivi Lind, lounge 8 baaridaam Kadri Kask ja Sampo Panga koolitusspetsialist, Aasta Teenindaja 2006 Aires Rühka. Kommenteerivad nende ülemused - Sampo Panga koolitusosakonna juhataja Külli Meier, Eesti Gaasi juhatuse esimees Aarne Saar ja lounge 8 mänedžer Heinar Õispuu

  8. Corporate reputation : intangible assets, tangible benefits / Katrin Rahu, Evelin Ojamets

    Index Scriptorium Estoniae

    Rahu, Katrin, 1978-

    2004-01-01

    Hill & Knowlton'i Eesti ning Läti büroode poolt tipp- ja keskastme juhtide seas 2004. a. sügisel läbiviidud uuringust korporatiivse imago kohta, mis on osa 1997. a. alustatud rahvusvahelisest uuringuprojektist Corporate Reputation Watch. Tabel. Diagrammid

  9. Kas sa kuuled mind? / Anete Elken, Katrin Kivirand

    Index Scriptorium Estoniae

    Elken, Anete

    2005-01-01

    Organisatsiooni EuroChild AISBL eestvedamisel Brüsselis toimunud noorte ürituse raames "Can you hear me?" arutasid Euroopa Liidu liikmesriikide esindajad noortega seotud probleeme ning kohtusid Euroopa Parlamendi liikmetega

  10. Tulevikuideed pärinevad loodusest / Katrin Kurss

    Index Scriptorium Estoniae

    Kurss, Katrin

    2010-01-01

    KUMU kunstimuuseumi auditooriumis 14. jaanuaril 2010 toimunud Eesti Kulinaaria Instituudi poolt korraldatud I rahvusvaheline Eesti köögi arendamisele pühendatud Food For Future / Tulevikutoidu konverentsist, kus esinesid ettekannetega toidumaailma uuendajad Albert Adriá, Fergus Henderson, Põhjala köögi liikumise üks algataja Claus Meyer ning reklaamibüroo Division loovjuht Rain Pikand

  11. Alkoholi tootmine ja turg : [2002-2004] / Katrin Karolin

    Index Scriptorium Estoniae

    Karolin, Katrin

    2005-01-01

    Ilmunud ka: Agriculture and the development of rural life : overview 2004/2005. - Tallinn, 2005, lk. 45-47. 2004. a. 9 kuu alkoholi jaekäive ulatus 2,2 mld kroonini, mis on 13% suurem kui eelmise aasta samal perioodil. Tabelid: Alkohoolsete jookide tootmine Eestis (9 kuud 2002-2004); Alkoholi tarbimine elanike hinnangute alusel

  12. Laste joonistatud perepiltidel seisavad kõrvutud vanemad / Katrin Johanson

    Index Scriptorium Estoniae

    Johanson, Katrin

    2008-01-01

    Psühholoog Toivo Niiberg põhjustest, miks tekitab Karksi-Nuia noorteteatri dokumentaalne lavalugu "Kallid vanemad" äratundmist. Loo seadis Viljandimaa põhikooliõpilaste kirjanditest kokku teatri juht ja lavastaja Silvia Soro

  13. 100 + 100 paremat raamatut / Katrin Männi

    Index Scriptorium Estoniae

    Männi, Katrin

    2002-01-01

    Eesti Raamatu Aasta 1935-1936: Paremate eesti raamatute soovitusnimestik; "Ideaalraamatukogu". Eesti Raamatu Aasta 2000-2001: 100 Eesti elu enim mõjutanud raamatut ; "Kuldraamatukogu"; Õpetatud Nõukogu valik

  14. "Tallinna vabastamist tuleks tähistada puhkpilliorkestriga!" / Katrin Rohtla

    Index Scriptorium Estoniae

    Rohtla, Katrin, 1966-

    2007-01-01

    Esmakordselt tähistati vastupanuvõitluse päeva, meenutades Eesti seadusliku valitsuse kukutamist 1944. aasta 22. septembril. Tallinna vabastamise päeva tähistajad Tõnismäel ja sõjaväekalmistul. Vt. samas: Gräzin: Hitleri ja Klenski metoodika on samad

  15. Põhja-Euroopa vägevaim kokk / Katrin Kurss

    Index Scriptorium Estoniae

    Kurss, Katrin

    2007-01-01

    Rahvusvahelisest kokkade võistlusest "Global Chef Challenge" ning seal osalenud kokkadest: Tom Victor Gausdal Norrast ; Carina Brydling Rootsist ; Thorsten Schmidt Taanist ; Simon Hulstone Suurbritanniast

  16. Kes kardab punast, kollast ja sinist? / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2002-01-01

    Ameerika kunstniku Barnett Newmani (1905-1970) tööde näitus Londonis Tate Modernis 5. jaanuarini 2003. 13. XI avati saksa päritolu ameerika kunstniku Eva Hesse (1936-1970) retrospektiivnäitus, mis sisaldab üle 130 skulptuuri, maali ja joonistuse

  17. Eesti põllumajandusest 1999. aastal / Katrin Noorkõiv

    Index Scriptorium Estoniae

    Noorkõiv, Katrin, 1973-

    2000-01-01

    Põllumajandusministeeriumi ülevaade koostamisel Eesti põllumajandusest aastal 1999 on rakendatud ühtse põllumajandussektori majandusliku arvestuse metoodikat (EAA - Economic accounts for agriculture). Tabelid, diagrammid

  18. Plaadid / Urmas Piht, Katrin Malt, Virko Pirrus...[jt.

    Index Scriptorium Estoniae

    2008-01-01

    Uutest heliplaatidest Destruction "D.E.V.O.L. U.T.I.O.N.", Ihsahn "angL", Neuraxis "The Thin Line Between", Kamphar "Heimgang", Satyricon """My Skin Is Cold", Venom "Hell", Bloodbath "The Waken Carnage"

  19. Kõrvemaa Karikas 2011 / Katrin Liiv, Õnne Halliko

    Index Scriptorium Estoniae

    Liiv, Katrin

    2011-01-01

    MTÜ Estonian Endurance Riding poolt Kõrvemaa Matka- ja Suusakeskuses korraldatud kestvusratsutamise võistlusest Kõrvemaa Karikas 2011, kus selgitati ka poniklassi Eesti meistrid kestvusratsutamises

  20. Klaaspärlimäng peletab klassikahirmu / Katrin Nielsen

    Index Scriptorium Estoniae

    Nielsen, Katrin

    2003-01-01

    Eri stiile-ajastuid ühendavast Peeter Vähi kujandatud muusikafestivalist "Klaaspärlimäng" 22. juulist-24. augustini. Kontsertidest Pärnu kontserdimajas: gamelaniansambli Gamelan Son of Lion kontserdist 22. juulil, Vardo Rumesseni kontserdist ja CD esitlusest 28. juulil, tütarlastekoori "Ellerhein" kontserdist 30. juulil

  1. Commissioning of the vacuum system of the KATRIN Main Spectrometer

    Czech Academy of Sciences Publication Activity Database

    Arenz, M.; Dragoun, Otokar; Kovalík, Alojz; Lebeda, Ondřej; Ryšavý, Miloš; Sentkerestiová, Jana; Slezák, Martin; Špalek, Antonín; Vénos, Drahoslav; Zbořil, Miroslav

    2016-01-01

    Roč. 11, APR (2016), P04011 ISSN 1748-0221 R&D Projects: GA ČR(CZ) GAP203/12/1896; GA MŠk LG14004 Institutional support: RVO:61389005 Keywords : gas systems and purification * neutriono detectors * spectrometers Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders Impact factor: 1.220, year: 2016

  2. Väikeste naiste oma ruum / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    1998-01-01

    Näitus "(Meta)Dialoog" A. H. Tammsaare muuseumis ja Kastellaanimaja galeriis. Kuraator Reet Varblane. Osalejad : Kiwa, Mari Laanemets, Helen ? (Helena) Lehtmets, Ele Praks, Piia Ruber, Liina Siib, Helena Palm, Kadi Soosalu, Killu Sukmit. Kõik tööd näitusel käsitlevad naist.

  3. Kuidas NOMA maailma muudab / Taani Toiduorganisatsioon ; refereerinud Katrin Press

    Index Scriptorium Estoniae

    2012-01-01

    Uue Põhjala köögi kontseptsiooni välja töötanud Claus Meyeri ja Rene Redzepi restorani Noma, mis on kolmel korral maailma parimaks restoraniks tunnistatud, juurde loodud eksperimentaalgastronoomia laborist Nordic Food Labist, kus Põhjala maitseid kaardistab ameeriklane Lars Williams

  4. Venelastele kulub kümnendik rahast / Katrin Rohtla

    Index Scriptorium Estoniae

    Rohtla, Katrin, 1966-

    2007-01-01

    Venekeelse meedia osakaal eelmise aasta meediareklaamiturul oli vaid umbes 170 miljonit ehk 12,5% koguturust. Vt. samas: Mitte-eestlaste reklaamides on otstarbekas kombineerida võimalikult erinevaid kanaleid. Kommenteerivad Kristjan Seema ja Toomas Pärna

  5. Miteelustamise otsus Eestis / Eva Antsov, Saara Sadrak, Katrin Elmet ...[jt.

    Index Scriptorium Estoniae

    Antsov, Eva

    2017-01-01

    Ravitahtest ja mitteelustamise otsuse (ingl do not resuscitate, do not attempt resuscitation order) ajaloost, praktikast Eestis ja näiteid teistest riikidest ning arutletud mitteelustamise eetilise tagamaa, sotsiaalse tähenduse ja Eesti õigusloome puudujääkide üle ravipiirangute kontekstis

  6. Tere tulemast, Schengen : lillad õhupallid ja rokkivad poliitikud! / Katrin Rohtla

    Index Scriptorium Estoniae

    Rohtla, Katrin, 1966-

    2007-01-01

    Tallinna sadamas tähistati Eesti astumist Schengeni õigusruumi. Kohal viibisid ka president Toomas Hendrik Ilves, Portugali peaminister Jose Socrates, Euroopa Komisjoni president Jose Manuel Barroso ja komisjoni volinik Franco Frattini

  7. Kunst ja feminism EKMi [Eesti Kunsti Maailm] kontekstis / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    1998-01-01

    Uurimistööga seoses küsitles K. Kivimaa kahtekümmet kolme eesti kunstnikku (nimed toodud), uurides nende suhet kaasaegse kunstiga ja suhtumist eesti kaasaegse kunsti feministlikesse ja soolistesse tendentsidesse. Kas kunstnikul on sugu? Suhtumine feminismi ja feministlikku kunsti. Feministist kunstnik, kunstnikust feminist. Soov osaleda feministlikel näitustel. Feministlik kriitika. Feministlike ja sookriitiliste teemadega tegeleva kunsti ja kunstnike endi koht laiemas kunstikontekstis. Eeskuju ja genereerija tähtsus. Järgneb 6. nov. lk. 10 ja 20. nov. lk. 12-13, 1998

  8. Plaadid / Katrin Malt, Mart Virkus, Virko Pirrus...[jt.

    Index Scriptorium Estoniae

    2008-01-01

    Uutest heliplaatidest Avantasia "The Scarecrow", Crematory "Pray", Black Comedy "Instigator", Behexen "My Soul For His Glory", Draconian "Turning Season Within", Earth "The Bees Made Honey in the Lion's Skull", Devotus Regnum "Centuries Conversely"

  9. Laste hulk ei sõltu toonekurgede arvukusest / Katrin Saks

    Index Scriptorium Estoniae

    Saks, Katrin, 1956-

    2006-01-01

    Perekonnaseaduse eelnõust ja samasooliste abielust. Sama ka Harjumaa 24. jaan. 2006, lk. 2 ; Võrumaa Teataja 24. jaan. 2006, lk. 2 ; Vali Uudised 25. jaan. 2006, lk. 2 ; Meie Maa 25. jaan. 2006, lk. 2 ; Hiiu Leht 27. jaan. 2006, lk. 2 ; Kuulutaja 27. jaan. 2006, lk. 4 ; Lõunaleht 26. jaan. 2006, lk. 2 ; Vooremaa 26. jaan. 2006, lk. 2 ; Pärnu Postimees 2. veeb. 2006, lk. 11 ; Sakala 2. veeb. 2006, lk. 2 ; Valgamaalane 25. aprill 2006, lk. 2 ; Hiiu Leht 9. mai 2006, lk. 2 ; Sotsiaaldemokraat 16. veeb. 2006, lk. 5

  10. Millest sõltub teatrikeele mõistetavus ? / Katrin Ruus

    Index Scriptorium Estoniae

    Ruus, Katrin

    2006-01-01

    2.-8. aug. Fääri saartel T̤rshavnis toimunud IV Põhjamaade amatöörteatrite festivalist (North European Amateur Theatre Alliance). Pikemalt Fääri harrastustrupi lavastusest "H̤rpurima" (lav. Hans T̤rgard), rootsi lavastaja ja draamakirjaniku "Õnnelikult igavesti", Islandi trupi "Memento mori" (lav. Augusta Skټlad̤ttir). Eestit esindas festivalil Tarmo Tagametsa lavastus "Hing?" Võru Teatriateljee esituses

  11. Saared meis ja meie ümber / Katrin Nielsen

    Index Scriptorium Estoniae

    Nielsen, Katrin

    1998-01-01

    Chaplini kunstikeskuses 17. detsembrini avatud fotonäitusest 'Põhjala saared', kus oma töid eksponeerisid: Absalon Hansen - Fääri saartest, Göte Ask - Gotlandist, Andy Horner - Ahvenamaalt, ning Tartu kunstikooli fotoeriala tudengid oma pilte Naissaarest, Piirissaarest, Abrukast, Manijast, Vormsist ja Vilsandist.

  12. Ons surm väljatõugatute paradiis? / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2004-01-01

    Mängufilm "Koletis" ("Monster") : režissöör Patty Jenkins : Ameerika Ühendriigid 2003. Filmi prototüübi, sarmõrvar Aileen Wuornosi (1956-2002) vägivaldsuse kujunemise põhjustest, naistele suunatud vägivallast ka Eestis

  13. Eestvedamine / Jüri Krusealle, Katrin Kreegimäe

    Index Scriptorium Estoniae

    Krusealle, Jüri

    2002-01-01

    Bibliogr. lk. 80. - Kokkuvõte ingl. k. lk. 80. Eesti juhtidel on veel palju õppida eestvedamise olemusest, et olla just selline liider, keda organisatsioonile tänapäeva kiiresti muutuvas maailmas vaja. Tabel liidrite tüüpidest

  14. Pikk tee märkamiseni / Katrin Saks

    Index Scriptorium Estoniae

    Saks, Katrin, 1956-

    2008-01-01

    Õpilaste koolisuhetest ning koolivägivallast. Ilmunud ka Vooremaa 9. okt. 2008, lk. 2 ; Võrumaa Teataja 11. okt. 2008, lk. 2 ; Koit 11. okt. 2008, lk. 6 ; Meie Maa 13. okt. 2008, lk. 2 ; Pärnu Postimees 10. okt. 2008, lk. 15 ; Virumaa Teataja 15. okt. 2008, lk. 11

  15. Äraaetud hobused lastakse maha / Katrin Saks

    Index Scriptorium Estoniae

    Saks, Katrin, 1956-

    2008-01-01

    Tööaja direktiivi muutmise eelnõust, mis suurendaks töötajate tööaja piiranguid. Ilmunud ka Põhjarannik 19. juuni 2008, lk.2 ; Vooremaa 21. juuni 2008, lk. 2 ; Virumaa Teataja 27. juuni 2008, lk. 11 ; Pärnu Postimees 27. juuni 2008, lk. 15 ; Järva Teataja 1. juuli 2008, lk. 2 ; Koit 3. juuli 2008, lk. 6 ; Nädalaleht 20. juuni 2008, lk. 7

  16. Loeme veel! / Kristi Pärn-Valdoja, Katrin Pauts

    Index Scriptorium Estoniae

    Pärn-Valdoja, Kristi, 1970-

    2006-01-01

    TNS Emor väärtushinnangute uuringu RISC 2006 andmetel on igapäevane lugemisharjumus 29 protsendil Eesti naistest ja 20 protsendil meestest. Tallinna abilinnapea Kaia Jäppinen, investeerimistoodete turundusjuht Piret Reinson, KUMU direktor Sirje Helme, laulja Maarja-Liis Ilus ning näitleja Riina Maide kõige enam nende elu ja tegevust mõjutanud raamatutest. Lisa: Millised on Hollywoodi naiste lemmikraamatud?

  17. Taarausuliste haigla jääb personalita / Katrin Pauts

    Index Scriptorium Estoniae

    Pauts, Katrin, 1977-

    2001-01-01

    Taarausuliste liider Rootsi eestlane Addold Mossin soovib Valgamaale rajada erihaigla, kus arstide kõrval hakkavad inimesi ravima ka nõiad. Professor Aili Paju ei kavatse taarausuliste haiglasse tööle minna

  18. Feministlikul mõttel on koht meie kunstiajalugudes : intervjuu kunstiakadeemia dotsendi Katrin Kivimaaga : feminism / Katrin Kivimaa ; interv. Reet Varblane

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2004-01-01

    Feministlikust kunstist ja kunstimõttest Eestis, feminismi mõistmisest Ungaris ja Inglismaal, muutustest eesti ühiskonnas võrdõiguslikkuse mõttes, uue feministliku kunstimõtte kogumiku ilmumise vajalikkusest jm.

  19. Pharmacokinetics, Biodistribution, and Toxicity Evaluation of Anti-SEMA3A (F11) in In Vivo Models.

    Science.gov (United States)

    Lee, Jaehyun; Kim, Donggeon; Son, Eunju; Yoo, Su-Ji; Sa, Jason K; Shin, Yong Jae; Yoon, Yeup; Nam, DO-Hyun

    2018-05-01

    The aim of our study was to investigate the pharmacokinetics (PK), tissue distribution and toxicity of F11 antibody to semaphorin 3A in mouse models and explore its anti-angiogenic and tumor-inhibitory effect. Patient-derived xenograft (PDX) models were established via subcutaneous implantation of glioblastoma multiforme (GBM) cells and treated with F11. F11 significantly attenuated tumor growth and angiogenesis in the GBM PDX model. Within the range of administered doses, the PK of F11 in serum demonstrated a linear fashion, consistent with general PK profiles of soluble antigen-targeting antibodies. Additionally, the clearance level was detected at between 4.63 and 7.12 ml/d/kg, while the biological half-life was measured at 6.9 and 9.4 days. Tissue distribution of F11 in kidney, liver and heart was consistent with previously reported antibody patterns. However, the presence of F11 in the brain was an interesting finding. Collectively, our results revealed angiogenic and tumor-inhibitory effect of F11 antibody and its potential therapeutic use within a clinical framework based on PK, biodistribution and toxicity evaluation in mouse models. Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  20. Flora Livonica : kalender 2008 = Calendar 2008 / Tallinna Ülikool, Akadeemiline Raamatukogu ; tekst Katrin Kaugver ; tõlkinud Kristi Rae, Katrin Kaugver

    Index Scriptorium Estoniae

    2007-01-01

    Kalendri illustratsioonid pärinevad raamatust: Drümpelmann, Ernst Wilhelm. Flora Livonica, oder: Abbildung und Beschreibung der in Livland wildwachsenden Pflanzen, bearbeitet in Verbindung mit einigen Freunden der vaterländischen Naturkunde. Riga, 1810

  1. Postkommunistlik kultuur ja kunst - kas müürid on lõhutud ? / Katrin Käärik ; foto: Katrin Käärik

    Index Scriptorium Estoniae

    Käärik, Katrin, 1950-

    1999-01-01

    Stockholmi Moodsa Kunsti Muuseumis avati 16. oktoobril 1999 rahvusvaheline näitus "Pärast müüri : kunst ja kultuur postkommunistlikus Euroopas", näitusest võtavad osa Jaan Toomik, Liina Siib, Kai Kaljo ja Inessa Josing

  2. Vaatamise viisid ja ühisväli = Perspectives and common field : [juhtkiri] / Katrin Koov

    Index Scriptorium Estoniae

    Koov, Katrin, 1973-

    2016-01-01

    Peatoimetaja mõtteid erinevatest kultuuridest, nende segunemisest ja sellest kuidas inimesed läbi aegade eri kohtades on elanud ning kuidas seda on tõlgentatud. Juhtkirjas on ka ajakirja sisu lühitutvustus

  3. Raha lastele! Ühe kodanikualgatuse lugu / Katrin Väljataga

    Index Scriptorium Estoniae

    Väljataga, Katrin

    2011-01-01

    Üks Tallinnas elav ema nõudis sotsiaalvõrgustikus Facebook Tallinna TV raha andmist lasteaedadele, kuna oli linna 2011. aasta esimese lisaeelarve investeeringute tabelit vaadates avastanud, et Tallinna TV saab 2011. aastal rohkem raha kui Tallinna lasteaiad (vastavalt 1,9 miljonit ja 127 823 eurot). Lasteaiade olukorrast. MTÜ Kodaniku Hääl esindajad on kohtunud mitmete ametnikega

  4. Katrin Pudersell kaitses farmaatsiadoktori väitekirja / Ain Raal, Elmar Arak

    Index Scriptorium Estoniae

    Raal, Ain, 1961-

    2006-01-01

    3. mail 2006 kaitses farmaatsiamagister Tartu Ülikooli arstiteaduskonna nõukogu ees doktoriväitekirja "Tropaanalkaloidide ja riboflaviini produktsioon koera-pöörirohu (Hyoscyamus niger L.) põllu- ja koekultuurides

  5. Kolm pilku uuele majale = Three Looks at a New House / Katrin Paadam

    Index Scriptorium Estoniae

    Paadam, Katrin, 1954-

    2005-01-01

    Neljakorruseline siseõuega korterelamu Tallinnas Lillekülas. Projekteerija: QP Arhitektid. Arhitekt Tõnu Laigu. Konstruktor: M.S.I. Grupp. Projekt 2002, valmis 2003. Ill.: I ja II korruse plaan, lõige, 6 värv. välisvaadet. Bibliograafia lk. 44

  6. Maastikuarhitektuuri koolitusest Eesti Kunstiakadeemias = Schooling in Landscape Architecture at the Estonian Academy of Art / Katrin Koov

    Index Scriptorium Estoniae

    Koov, Katrin, 1973-

    2003-01-01

    Maastikukool tegutseb EKA arhitektuuriosakonna juures neljandat hooaega. Seni oli tegemist valikkursusega, 2003/2004. õppeaastast on see lülitatud arhitektuuriüliõpilaste põhiõppesse. Maastikukooli eesmärgist ja plaanidest, ülevaade aastatel 2000-2003 toimunud maastikukoolidest. 6 ill

  7. Koda = Koda / Ülar Mark, Kariina Kristiina Kaufmann, Kadri Tonto ; kommenteerinud Katrin Koov

    Index Scriptorium Estoniae

    Mark, Ülar, 1968-

    2016-01-01

    Minimalistliku vormiga eramu KODA Tallinnas, Järvekalda tee 33. Autorid Ülar Mark, Taavi Jakobson, Hannes Tamjärv, Kalev Ramjalg, Marek Strandberg. Arhitektid Ülar Mark, Kariina Kristiina Kaufmann, Kadri Tonto, Hannes Praks

  8. XI Põhjamaade kunsti ja kirjanduse festival "Les Boréales" / Katrin Talts

    Index Scriptorium Estoniae

    Talts, Katrin

    2002-01-01

    Festival toimub 22.-30. nov. Prantsusmaal Caenis. Kirjanduslikel debattidel tutvustatakse Tõnu Õnnepalu, Jaan Kaplinski, Mati Undi, Eva Koffi ja Arvo Valtoni loomingut. Festivali teemaks on "Territoorium ja identiteet"

  9. Tallinna Pedagoogikaülikooli magistreid 2004 / Katrin Aava, Toomas Liiv, Helle Metslang

    Index Scriptorium Estoniae

    Aava, Katrin, 1963-

    2005-01-01

    Eesti keele, soome keele ja kommunikatsiooni eriala magistritöödest. Ka viis kirjandusteaduslikku tööd: Kerli Linnati "The vision of history of E. L. Doctorow in English and in Estonian: a comarative study of "Ragtime" and "Look Lake" and their translations", Anneli Niitsoo "Postmodern play with power and masculinity in Jeanette Winterson's Novels", Pille Riismaa "Gümnaasiumi kirjandusõpik "Eelmise sajandi eesti kirjandus"", Anneli Kõvamehe "Baltisakslased Jaan Krossi "Kolmandates mägedes", "Keisri hullus" ja Rakvere romaanis"", Jaak Urmeti "Kultuuri eest ja religiooni vastu. Max Laossoni usuvastasest paljastustööst ajakirjas "Ratsionalist" (1932-1933)"

  10. Feministlik poliitika ja institutsioonikriitika / Angela Dimitrakaki ; tõlkinud Katrin Kivimaa

    Index Scriptorium Estoniae

    Dimitrakaki, Angela

    2011-01-01

    Ettekanne sümpoosionil "Common Differences: Issues for Feminist Curating in Post-Socialist Europe" Eesti Kunstiakadeemias 27. mail 2011. Kuratoorse ühisvara idee nõuab kahekordset distantseerumisakti - eemaldumist kapitali huvides töötavatest (kunsti)institutsioonidest ning kunsti ja kunstiajaloo teenistusest

  11. Jõhkrad mängud - meelelahutus või mitte? / Katrin Nigul

    Index Scriptorium Estoniae

    Nigul, Katrin

    2008-01-01

    Austria režissööri Michael Haneke 1997. aastal valminud psühhodraama "Jõhkrad mängud" ("Funny Games") Ameerikas sama lavastaja käe all valminud uusversioon ("Funny Games U.S") : Ameerika Ühendriigid 2007

  12. Müüte tervishoiu rahast ja arstide-õdede palkadest / Katrin Rehemaa

    Index Scriptorium Estoniae

    Rehemaa, Katrin

    2007-01-01

    Ilmunud ka: Põhjarannik, 13. jaan. 2007, lk. 2; Severnoje Poberezhje, 13. jaan. 2007, lk. 2; Oma Saar, 16. jaan. 2007, lk. 4; Koit, 16. jaan. 2007, lk. 6; Võrumaa Teataja, 16. jaan. 2007, lk. 2; Lääne Elu, 16. jaan. 2007, lk. 2; Vali Uudised, 17. jaan. 2007, lk. 2; Vooremaa, 18. jaan. 2007, lk. 2. Eesti Arstide Liidu peasekretär selgitab kriisiolukorraga sündinud müüte, mis on tekkinud tervishoiu rahastamisega seoses

  13. Sotsiaalne kapital ja jätkusuutlik majandusareng / Helje Kaldaru, Katrin Tamm

    Index Scriptorium Estoniae

    Kaldaru, Helje, 1950-

    2003-01-01

    Ülevaade sotsiaalse kapitali mõistest ja peamistest suundumustest selle käsitlemisel, sotsiaalse kapitali mõõtmise võimalustest. Sotsiaalse kapitali analüüs Eestis võrrelduna Euroopa Liidu liikmesmaade, teiste kanditaat- ja siirderiikidega, sotsiaalse kapitali kujunemine maakondade lõikes. Tabelid

  14. Kiirus 2 ehk kunsti võimalustest ajupesu ühiskonnas / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    1998-01-01

    Maanteenäitus 'Kiirus 2'. Kuraator Mari Sobolev. Osalejad loetletud. K. Putki, P. Alliku, J. Zoova, M. Laimre, M. Mäetamme, Sütevaka Andrese, P. Pajose, E. Müürsepa, T. Laamannni töödest. Pikemalt Andrus Joonase tööst 'Artist Kills the Beast' 1997. a. näituselt 'Kõike korraga ja palju'.

  15. Muljeid Stockholmi mööblimessilt (6.-10. veebruarini 2007) / Katrin Kask

    Index Scriptorium Estoniae

    Kask, Katrin

    2007-01-01

    Eesti firmadest osalesid messil Softrend, Wallenium ja Thulema. Messihoone vestibüüli kujundas saksa disainer Konstantin Grcic, tema loomingust. Rootsi disaineri Damian Williamsoni installatsioonist "The Silent Supper"

  16. Aasta jagu filme linastus pealinnas ühe matsuga / Katrin Nielsen

    Index Scriptorium Estoniae

    Nielsen, Katrin

    2001-01-01

    Pimedate Ööde Filmifestivali huvitavamaid filme : Jan Hrebejk'i "Lahus olles me kaotame" (Tšehhi Vabariik 2000), Oliver Hirschbiegeli "Eksperiment" (Saksamaa 2001) ja Bille Augusti "Laul Martinile" (Rootsi - Taani 2001)

  17. "Mida mina ei julge, teeb Homer filmis ära!" / Katrin Pauts

    Index Scriptorium Estoniae

    Pauts, Katrin, 1977-

    2007-01-01

    21. juulil on joonisfilmi "Simpsonite film" ("The Simpsons Movie") maailmaesilinastus. Seriaali suur fänn, saatejuht Kristjan Jõekalda sellest, miks talle Simpsonid meeldivad. Lisaks "Marge'i juuksed on inspireeritud Frankenteini pruudist"

  18. Näitleja teeb vahekokkuvõtte ehk Kuidas lavastatakse aega / Katrin Ruus

    Index Scriptorium Estoniae

    Ruus, Katrin

    2006-01-01

    Von Krahli Teatri kolmest lavastusest: "Erki ja Tiina" (lavastaja Mart Kangro, tantsivad Erki Laur ja Tiina Tauraite), "Faust" (J. W. Goethe ainetel tekst ja lavastus Taavi Eelmaa, muusika ja laulud Chalice, osades Jarek Kasar ja Rein Pakk), "Hamletid" (William Shakespeare'i ainetel kontseptsiooni, lavastuse, koreograafia, kujunduse, valguse autor Sasha Pepeljajev, video- ja helikunstnik Taavet Jansen. Esitaja Juhan Ulfsak)

  19. Kolm küsimust Rait Pärgile / Rait Pärg ; interv. Katrin Nielsen

    Index Scriptorium Estoniae

    Pärg, Rait

    2001-01-01

    Skulptor Rait Pärg Pärnu skulptuurikaardi ja selle põhjal skulptuurikontseptsiooni koostamisest (osalevad ka Omar Volmer ja Mark Soosaar), 2.-11. juunini korraldatavatest skulptuuripäevadest "Pärnu - positiivse märgiga linn"

  20. Valitsusliit jätab lasteaiaõpetajad virelema / Katrin Saks

    Index Scriptorium Estoniae

    Saks, Katrin, 1956-

    2004-01-01

    Koolieelsete lasteasutuste seaduse muutmise seaduseelnõu hääletati Riigikogu menetlusest välja, vanemahüvitistest. Ilmunud ka Pärnu Postimees 23. sept. 2004, lk. 15 ; Hiiu Leht 24. sept. 2004, lk. 2 ; Sakala 24. sept. 2004, lk. 2 ; Vali Uudised 24. sept. 2004, lk. 2 ; Nädaline 23. sept. 2004, lk. 4 ; Põhjarannik 24. sept. 2004, lk. 2 ; Türi Rahvaleht 24. sept. 2004, lk. 4, Meie Maa 28. sept. 2004. lk. 2 ; Koit 30. sept. 2004, lk. 6 ; Vooremaa 7. okt. 2004, lk. 2 ; Valgamaalane 16. okt. 2004, lk. 2

  1. Agar pronkssõduriga võitleja sai kanepisuitsetamise eest trahvi / Katrin Rohtla, Siim Randla

    Index Scriptorium Estoniae

    Rohtla, Katrin, 1966-

    2006-01-01

    Aktiivse pronkssõduri vastasena tuntust kogunud Isamaaliidu liige Kalev Rebane sai Läänemaal Peraküla rannas kanepi suitsetamise eest politseilt 9000 krooni trahvi. Isamaa ja Res Publica Liidu liikmed on teinud ettepaneku noormees erakonnast välja arvata. Lisa: Mille eest koostati protokoll?

  2. Järeltuuril Moravias, Sloveenias ja Ungaris / Krista, Ruth ja Katrin

    Index Scriptorium Estoniae

    Jürisoo, Krista

    2010-01-01

    24.-26. jaanuaril 2010 toimunud Austria ja Kesk-Euroopa turismimessil actb 2010 korraldatud konverentsist Actb Vienna osavõtjatele pakutud võimalusest tutvuda Tšehhi, Ungari või Sloveenia turismisihtkohtadega 3-päevasel õppereisil

  3. Euroopa uue draama festival "A Est" Napolis / Mari Kolle, Katrin Talts

    Index Scriptorium Estoniae

    Kolle, Mari

    2005-01-01

    Festival toimub 9.-11. veebr. Napolis. Eesti näitekirjandusest tõlgiti selleks puhuks itaalia keelde kolm näidendit : J. Tätte "Sild", A. Kivirähki "Eesti matus" ja U. Lennuki "Rongid siin enam ei ..." Sel korral neid avalikult ette ei loeta, kuid nad on kättesaadavad kõigile huvilistele

  4. Tulevikuteatri nimel, nüri järjekindlusega - edasi ! / Katrin Nielsen

    Index Scriptorium Estoniae

    Nielsen, Katrin

    2001-01-01

    2001. a. 20. märts oli esimene aasta, mil ülemaailmsesse organisatsiooni ASSITEJ kuuluvad laste- ja noorteteatrid tähistasid lasteteatrite päeva. Eesti ASSITEJsse (asutatud 1992. a.) kuuluvad VAT Teater, Narva Teater Ilmarine, Jõhvi teatrid Tuuleveski ja Lepatriinu, Tartu Minerva, Tallinna Reel, Viljandi Nukuteater ning rida üksikliikmeid. Eesti keskuse tulevikuplaanidest

  5. Mosaiigitükid vajavad uut moodi kokkupanekut / Martin Klöker ; intervjueerinud Katrin Kaugver

    Index Scriptorium Estoniae

    Klöker, Martin, 1966-

    2012-01-01

    Intervjuu kirjandus- ja kultuuriloolase Martin Klökeriga, kes viibis TLÜAR-i kutsel 2012. a märtsis Tallinnas ning pidas avaliku loengu "Ebatäielik pilt: trükitud raamat ja käsikiri kultuuride uurimises" ning kokkuvõte loengust

  6. CSR - fashion word or strategic approach? / Katrin Vernik, Fred Nahkur ; interv. Evelyn Ojamets

    Index Scriptorium Estoniae

    Vernik, Katrin, 1975-

    2006-01-01

    A. Le Coq Tartu Õlletehase turundusjuht ja Procter & Gamble'i Balti regiooni avalike ja välissuhete juht selgitavad, kuidas on ettevõtte sotsiaalse vastutuse kontseptsioon leidnud rakendust nende organisatsioonides

  7. Evelin Ilves asus Šveitsi suurfirma ausaadikuks. Meeleheaks 52 000 krooni maksev kell / Katrin Rohtla

    Index Scriptorium Estoniae

    Rohtla, Katrin, 1966-

    2008-01-01

    17. mail 2008 oli Estonia teatris "Tristani ja Isolde" esietendus, kus proua Evelin Ilves nimetati Šveitsi luksuskellade meistri Raymond Weili ausaadikuks. Tiitliga kaasnes kingitusena teemantidega käekell. Kommenteerivad Aktsiaseltsi Balti Kell juhataja Toivo Aalja ja proua E. Ilvese erasekretär Piia Vann. Vt. samas: Kadri Simson: ausaadik on peen nimetus reklaamnäole. Riigikogu korruptsioonivastase seaduse kohaldamise erikomisjoni liikme Kadri Simsoni kommentaar. Vt. ka juhtkiri lk. 8: Reklaampost. SL Õhtulehe arvates on sobimatu, et presidendiproua seotakse ühe äriettevõtte huvidega

  8. Üks suund, kaks vaadet / Tiit Land, Argo Ralja ; intervjueerinud Katrin Reimann

    Index Scriptorium Estoniae

    Land, Tiit, 1964-

    2012-01-01

    Intervjuu Tallinna Ülikooli rektori Tiit Landi ja Üliõpilaskonna juhatuse esimehe Argo Raljaga Tallinna Ülikooli iseloomustavatest märksõnadest möödunud aastal, positsioonist Eesti hariduses, ülikooli koostööst instituutide ja kolledžitega

  9. How the complete brand was created? / Katrin Vernik ; interv. Oksana Kostina

    Index Scriptorium Estoniae

    Vernik, Katrin, 1975-

    2005-01-01

    Kuigi kodumaise limonaadi Limpa reklaamikampaaniaks kulus aastatel 2001-2004 kaheksa miljonit krooni, on A. Le Coq marketingijuhi sõnul investeeringud end igati õigustanud. Praeguseks on Limpa saanud kõige tuntumaks lastebrändiks Eestis ning müügiedu on kasvanud oodatust suuremaks

  10. Arafati nõunik : "Yasser on kuningas, kes elab vangis" / Walid Abu Zalaf ; interv. Katrin Lust

    Index Scriptorium Estoniae

    Abu Zalaf, Walid

    2004-01-01

    Yasser Arafati meedianõunik, Palestiina ja Araabia suurima lehe al-Quds tegevjuht vastab küsimustele oma töö, juutide-palestiinlaste vahelise viha, Arafati ning tema perekonna asupaiga kohta. Lisa: Nõunikud: Arafati elu pole ohus

  11. Maid mööda hargnenud pered / Katrin Uuspõld

    Index Scriptorium Estoniae

    Uuspõld, Katrin

    2017-01-01

    TLÜ Rakvere kolledž osaleb Eesti-Soome koostööprojektis REGI, mille eesmärk on toetada kahe riigi vahel hargnenud peresid. Mullu toimusid Rakvere kolledžis neljal korral teemaõhtud "Armastan sind kaugelt". Selgitusi jagavad TLÜ Rakvere kolledži lektor, pereterapeut ning Gordoni perekooli ja PREP-paarisuhte koolitaja Pille Murrik, TLÜ Rakvere kolledži arendusjuht ja REGI projekti Eesti koordinaator Kristel Mänd ning TLÜ Rakvere kolledži õppejuht Marje Lepanen

  12. Onu Miltie mälestuseks ehk Mis seob New Orleansi ja Keilat? / Katrin Saks

    Index Scriptorium Estoniae

    Saks, Katrin, 1956-

    2008-01-01

    16. novembril sai kaks aastat liberaalse majanduse guru Milton Friedmani surmast. Friedmani šokidoktriinist, katastroofikapitalismist ja pimedast usust erakapitali, ajal, mil Keila linnaisad olid otsustanud, et haridust hakkab munitsipaalkooli asemel edendama sihtasutus

  13. Kuulujututurunduse abil Eestis veel müüa ei õnnestu / Katrin Rohtla

    Index Scriptorium Estoniae

    Rohtla, Katrin, 1966-

    2007-01-01

    Maailmas on üha enam levimas kuulujututurundus (buzzmarketing), kus ettevõtted annavad trenditeadlikele arvamusliidritele testimiseks tooteid lootuses, et nood tooteid oma tutvusringkonnale edasi tutvustaksid. Kommenteerivad Merit Raju ja Meelis Vill

  14. Linn kui maastik / Eva Castro ; intervjueerinud Katrin Koov ; toimetanud Carl-Dag Lige

    Index Scriptorium Estoniae

    Castro, Eva

    2011-01-01

    Intervjuus Tallinna arhitektuuribiennaali ühe peaesineja Eva Castroga, kes on AB Groundlab arhitekt ja juhib Londoni Arhitektuuriühingu arhitektuurikoolis maastikuurbanismi magistriprogrammi, maastikuurbanismist ja selle õppekavast, Groundlabi projektide ja Londoni Arhitektuuriühingu arhitektuurikooli tudengite tööde näitusest Eesti Arhitektuurimuuseumis, visioonivõistlusest "Street 2020"

  15. Lühim tee iseendani läheb ümber maailma / Katrin Kaugver

    Index Scriptorium Estoniae

    Kaugver, Katrin, 1950-

    2007-01-01

    Euroopa Teadusraamatukogude Konsortsiumi (CERL) vanaraamatu seminarist Budapestis "Trükised ja omanikud : kirjeldades Euroopa kultuuri geograafiat" 2006. a. novembris. Esimest korda käis Eesti sel kokkusaamisel konsortsiumi täisliikme staatuses, TLÜ Akadeemiline Raamatukogu sai CERL-i täisliikmeks 2006. a.

  16. Teadmiste lõikepunkt : intervjuu Elmar Mittleriga / Elmar Mittler ; küsitlenud Katrin Kaugver

    Index Scriptorium Estoniae

    Mittler, Elmar

    2008-01-01

    Intervjuu Euroopa Teadusraamatukogude Konsortsiumi (CERL) esimehe ning Göttingeni Riigi- ja Ülikooliraamatukogu endise direktori Elmar Mittleriga, kes oli TLÜAR-i külaline ning pidas Tallinnas loengu "Libraries as worldwide infrastructures for open access"

  17. Kroonika esitleb : Justin Timberlake ja Rod Stewart / Justin Timberlake ; interv. Katrin Lust-Buchanan

    Index Scriptorium Estoniae

    Timberlake, Justin

    2006-01-01

    Meesteajakirja GQ auhindade jagamise tseremoonial Londonis sai ajakirja Kroonika reporter jutule aasta rahvusvahelisima mehe tiitli pälvinud Justin Timberlake'i ja elutööpreemia saanud Rod Stewartiga

  18. High-voltage monitoring with a solenoid retarding spectrometer at the KATRIN experiment

    Czech Academy of Sciences Publication Activity Database

    Erhard, M.; Bauer, S.; Beglarian, A.; Bergmann, T.; Bonn, J.; Drexlin, G.; Goullon, J.; Groh, S.; Gluck, F.; Kleesiek, M.; Haussmann, N.; Höhn, T.; Johnston, K.; Kraus, M.; Reich, J.; Rest, O.; Schlosser, K.; Schupp, M.; Slezák, Martin; Thummler, T.; Vénos, Drahoslav; Weinheimer, C.; Wüstling, S.; Zbořil, M.

    2014-01-01

    Roč. 9, JUN (2014), P06022 ISSN 1748-0221 R&D Projects: GA ČR(CZ) GAP203/12/1896 Institutional support: RVO:61389005 Keywords : real-time monitoring * spectrometers * control systems Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders Impact factor: 1.399, year: 2014

  19. Essenson tuleb välja soolotükiga / Katrin Essenson ; interv. Tiit Tuumalu

    Index Scriptorium Estoniae

    Essenson, Katrin, 1973-

    2005-01-01

    14. sept. esietendub Kanuti gildi saalis koreograafi, tantsija ja performance'i kunstniku K. Essensoni soololavastus "Manusega mõtted : Designed to make difference". Lavastusele on dramaturgina kaasa aidanud Von Krahli teatri näitleja T. Eelmaa

  20. Ajaloolise ja isikliku mälu arheoloogiast tulevikuvisioonideni / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2005-01-01

    Kuni 15. I 2006 Victoria ja Alberti muuseumis avatud näitusest "Mineviku ja tuleviku vahel", mis annab ülevaate hiina kaasaegse foto- ja videokunsti ning dokumentatsioonide kaudu ka performance'i hiljutisest arengust ja hetkeseisust ning toob nähtavale praegust hiina kultuuri mõjutavate traditsioonide ja uuenduste keerulise sasipuntra

  1. Kirjanduse ajalugu ja ühiskonna murrang / Pertti Lassila ; tlk. Katrin Raid

    Index Scriptorium Estoniae

    Lassila, Pertti

    1998-01-01

    Bibl. lk. 276. Kokkuvõte inglise k. lk. 317. Talve- ja Jätkusõja põhjustatud kriisist Soome ühiskonnas, mis lõpetas rahvusromantismi saja-aastase valitsusaja soome kirjanduses ja tõi kaasa 1950. a.-te modernismi.

  2. Pikiuuring õpetajaks õppijate professionaalse identiteedi kujunemisest / Katrin Poom-Valickis, Erika Löfström

    Index Scriptorium Estoniae

    Poom-Valickis, Katrin, 1969-

    2014-01-01

    Uurimusest, mille eesmärgiks oli analüüsida õpetajakoolituse üliõpilaste õpetajaidentiteedi aluseks olevaid tähendusi ja uskumusi, mis on loodud interaktsioonis keskkonnaga, sh ülikooli õpingute käigus kogetuga

  3. Vana vimm lõi Maltal välja / Katrin Pauts

    Index Scriptorium Estoniae

    Pauts, Katrin, 1977-

    2003-01-01

    President Arnold Rüütli Malta riigivisiidi ajal ütles presidendi protokolliülem Andrei Birov välisministeeriumi protokolliosakonna juhatajale Tiina Nirgile "Fuck you!". Riigivisiit Malta Vabariiki 1.-3.10.2003

  4. Elizabeth II tervitas Briti ja Eesti sõjaväelasi / Allar Viivik, Katrin Rohtla

    Index Scriptorium Estoniae

    Viivik, Allar

    2006-01-01

    Kuninganna Elizabeth II avas Eesti uue miinijahtija Admiral Cowani vapi ning kohtus Briti sõjalaeva Liverpool pardal Afganistanis võidelnud kaitseväelastega. Kuningannat saatis Eesti presidendipaar

  5. Balletistuudio tuli Itaaliast tagasi väärt kogemusega / Katrin Hommik

    Index Scriptorium Estoniae

    Hommik, Katrin

    2009-01-01

    Viljandi Jakobsoni gümnaasiumi balletistuudio saavutas Itaalias Spoletos rahvusvahelistel võistlustel finaalikoha. Balletistuudio osalemisest Põhja-Itaalias toimunud tantsufestivalil "Festival Internazionale della danza di Contemporanea"

  6. Kolm raamistikku Mäetamme unenäole / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2008-01-01

    Kunstniku unenäo materialiseerimisest ja aktualiseerimisest. Marko Mäetamme tekstilisest videoteosest "Pealkirjata" (2007), mis olevat ilmunud kunstnikule unenäos. Inglise kunstiajaloolane Fred Orton ameerika kunstniku Jasper Johnsi tööst "Lipp". S. Freudi teosest "Unenägude tõlgendamine"

  7. Kolm raamistikku Mäetamme unenäole / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2007-01-01

    Marko Mäetamme teosest "Kaotaja paradiis" Veneetsia biennaalil 2007. aastal. Kuraator Mika Hannula. S. Freudi unenägude käsitlusest. Inglise kunstiajaloolane Fred Orton ameerika kunstniku Jasper Johnsi tööst "Lipp"

  8. Properties of Kr-83m conversion electrons and their use in the KATRIN experiment

    Czech Academy of Sciences Publication Activity Database

    Vénos, Drahoslav; Sentkerestiová, Jana; Dragoun, Otokar; Slezák, M.; Ryšavý, Miloš; Špalek, Antonín

    2018-01-01

    Roč. 13, č. 2 (2018), č. článku T02012. ISSN 1748-0221 R&D Projects: GA MŠk LM2015056; GA MŠk LG14004 Institutional support: RVO:61389005 Keywords : detector alignment and calibration methods * neutrino detectors * spectrometers Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders OBOR OECD: Nuclear physics Impact factor: 1.220, year: 2016

  9. Eesti saatus - "ajude äravool" või "ajude ringlus"? / Katrin Oja

    Index Scriptorium Estoniae

    Oja, Katrin

    2005-01-01

    Kõrge kvalifikatsiooniga tööjõu liikumisest ja sellealastest uuringutest maailmas. Luule Sakkeuse ja Eesti Kõrgkoolidevahelise Demouuringute Keskuse korraldatud uuringust "Scientific Personnel in Estonia during the Transition Period" aastate 1989-1994 kohta ning 2003. aastal artikli autori poolt tehtud kvalitatiivsest uuringust Ameerika Ühendriikides elavate eestlaste seas. Skeem

  10. 10 aastat kostüümidraamat / Kaire Raave, Katrin Pauts, Kaja Roomets

    Index Scriptorium Estoniae

    Raave, Kaire

    2007-01-01

    Oma rõivastusest vabariigi aastapäeva presidendi vastuvõttudel räägivad Eesti Kunstiakadeemia rektor Signe Kivi, dirigent Eri Klasi abikaasa Ariel, Riigikogu liige Evelyn Sepp, tippärimehe Urmas Sõõrumaa kaasa Kätlin Maran ja Võru linnapea Ivi Eenmaa. Lisatud valik fotosid presidendi vastuvõttudest aastatel 1999-2006. Vt. samas: President Toomas Hendrik Ilves 9 aastat presidendi vastuvõtul. Pikemalt Signe Kivi kleitidest ja näitusest "24. veebruar" Disaini- ja Arhitektuurigaleriis, kus on eksponeeritud tema kõiki vastuvõttudel kantud kleite

  11. Teadmuspõhise ühiskonna ja elukestva õppe diskursuste rekontekstualiseerimine Eestis / Katrin Aava

    Index Scriptorium Estoniae

    Aava, Katrin, 1963-

    2011-01-01

    Uuritakse, kuidas Euroopa Liiduga ühinemisel rekontekstualiseeritakse Eesti hariduspoliitikas erinevate strateegiadokumentide vahendusel uued diskursused. Uurimuse objektiks on meediatekstid, mille põhjal selgitatakse välja, millal on kasutusele võetud uued võtmesõnad "teadmus" ja "elukestev"

  12. Riigikogu aseesimeeste valimine tekitas paksu verd : Res Publical riigikogu juhatuses kaks kohta / Katrin Pauts

    Index Scriptorium Estoniae

    Pauts, Katrin, 1977-

    2005-01-01

    Riigikogu aseesimeesteks valiti Res Publica liige Taavi Veskimägi ja Keskerakonna liige Toomas Varek. Opositsiooniparteil Res Publica on nüüd juhatuses kaks kohta. Erakondade juhtpoliitikute kommentaare

  13. Kunstnikumüüt ja hullumeelsus : Outsider-kunst / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2003-01-01

    Kuidas kunstnikumüüdid või -identiteedid võimaldavad või soodustavad autori kogemuste, sh. "hullumeelsuse" tõlkimist kunsti keelde. Marko Laimre sümboolsest samastumisest grafitilooja Ülo Kiplega ja M. Laimre fotoinstallatsioonist "Psycho" (2000). Vincent van Goghi geniaalsuse seotusest vaimuhaigusega, "hullu" kunstniku müüdist kunstiajaloos

  14. Gaseous source of 83mKr conversion electrons for the neutrino experiment KATRIN

    Czech Academy of Sciences Publication Activity Database

    Vénos, Drahoslav; Slezák, Martin; Dragoun, Otokar; Inoyatov, A.; Lebeda, Ondřej; Pulec, Zdeněk; Sentkerestiová, Jana; Špalek, Antonín

    2014-01-01

    Roč. 9, č. 12 (2014), s. 1-12 ISSN 1748-0221 R&D Projects: GA ČR(CZ) GAP203/12/1896 Institutional support: RVO:61389005 Keywords : detector alignment and calibration methods * spectrometers * neutrino detectors * dark matter detectors Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders Impact factor: 1.399, year: 2014

  15. Milleks põllumajandusmaastiku elurikkus? / Eneli Viik, Iiri Raa, Ere Ploomipuu, Katrin Vask

    Index Scriptorium Estoniae

    2012-01-01

    Elurikkus on meie maakeral leiduva kogu elusa looduse mitmekesisus, mida võib eristada kolmel tasandil: geneetiline tasand, liikide tasand, koosluste mitmekesisuse tasand. Kuidas säilitada elurikkust põllumajandusmaastikul

  16. Kas madonnale disainitud dress lõpetas prügikastis? / Kais Allkivi, Katrin Pauts

    Index Scriptorium Estoniae

    Allkivi, Kais

    2009-01-01

    Viru keskuse Bastioni poes tulevad müügile 25 rahvusmustriga dressi, mis on peaaegu identsed esileedi Evelin Ilvese palvel Bastioni moedisaineri Merike Pääro poolt Madonnale disainitud spordirõivastega

  17. Eesti teater välismaal : gastrollid ja saavutused aastal 2004 / Mari Kolle, Katrin Talts

    Index Scriptorium Estoniae

    Kolle, Mari

    2004-01-01

    Veebruaris andis Londoni Teatriühing balletipaarile A. Oks-T. Edur Briti teatripreemia, Laurence Olivier teatriauhinna; VAT Teatri lavastus "Kivid" hinnati Peterburi rahvusvahelisel noorsooteatrite festivalil "Vikerkaar" preemiaga "Parim lavastus väikesel laval"; Vanemuise lavastus "Roberto Zucco" võitis Poolas teatrifestivalil "Kontakt" II peaauhinna ja nimiosatäitja T. Tuisk parima noore näitleja auhinna; Von Krahli Teater võitis lavastusega "Luikede järv" New Yorgi Bessie-auhinna ; Jaapani rahvusvahelisel teatrifestivalil pälvis lavastaja J. Urvet parima meesnäitleja preemia osatäitmise eest "Niagaaras"; rahvusvaheliselt äratas tähelepanu eesti-soome ühistööna kirjutatud näidend "Taksojuhid", mille autorid on M. Ulman ja J. Niilekselä. Kaasaegse tantsu vallas olid rahvusvaheliste festivalide favoriidid M. Kangro, K. Essenson ja R. Keerd

  18. Muutuv ruum : meediakunst eesti kultuuris = Changing spaces : new media art in Estonian culture / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2004-01-01

    1990-ndate aastate Eesti kaasaegse kunsti arengust, selle medialiseerumisest, mida iseloomustab fotograafia, video ja arvutipõhise meedia tungimisest "kõrgesse kunsti", Mall Nukke, Tiia Johannsoni, Raivo Kelomehe ja Nelli Rohtvee netiprojektidest ning Ando Keskküla kureeritud rahvusvahelistest kunsti- ja meediaüritustest "Interstanding"1-3, ka Prantsuse-Balti videofestivalidest, uue meedia festivalist "Offline@online". Eestikeelne lühem variant ilmunud ajakirjas "Kunst.ee", 2001, nr.4, inglisekeelne - ajakirjas "Mare Articum", 2000, nr. 2(7)?

  19. Aeg ei küsi, kelle hinges laulab lind / Katrin Nielsen

    Index Scriptorium Estoniae

    Nielsen, Katrin

    2000-01-01

    Pärnu Mudaravilas avatud nongratalase Asta Isaku maalinäitusest "Looduses ja lootuses" ning Chaplini kunstikeskuses avatud Tammiste hooldekodu elaniku Aivar Kurvitsa maalinäitusest "Ära reosta loodust"

  20. KATRIN :a New Beta-Spectroscopic Experiment to Determine the Neutrino Mass

    Czech Academy of Sciences Publication Activity Database

    Dragoun, Otokar

    2007-01-01

    Roč. 958, - (2007), s. 193-196. ISBN 978-0-7354-0472-4. ISSN N R&D Projects: GA MŠk LC07050 Institutional research plan: CEZ:AV0Z10480505 Keywords : neutrino mass * beta ray spectroscopy Subject RIV: BE - Theoretical Physics

  1. Prototype of an angular-selective photoelectron calibration source for the KATRIN experiment

    Czech Academy of Sciences Publication Activity Database

    Valerius, K.; Hein, H.; Baumeister, H.; Beck, M.; Bokeloh, K.; Bonn, J.; Gluck, F.; Ortjohann, H.W.; Ostrick, B.; Zbořil, Miroslav; Weinheimer, Ch.

    2011-01-01

    Roč. 6, - (2011), P01002/1-P01002/11 ISSN 1748-0221 R&D Projects: GA MŠk LA318; GA MŠk LC07050 Institutional research plan: CEZ:AV0Z10480505 Keywords : Spectrometers * Photoemission * Detector alignment and calibration methods (lasers, sources, particle-beams) Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders Impact factor: 1.869, year: 2011

  2. Good corporate reputation - a key to a client's heart / Katrin Rahu, Evelin Ojamets ; interv. Oksana Kostina

    Index Scriptorium Estoniae

    Rahu, Katrin, 1978-

    2005-01-01

    Hill & Knowlton Estonia poolt läbi viidud uurimusest selgus, et inimesed nii Eestis, Lätis kui ka Leedus peavad organisatsiooni tööle asumisel tähtsaks ettevõtte, eriti selle mikrokliima, head mainet. Eesti puhul ilmnes üllatuslikult, et karjäärivõimalused töökoha valikul tähtsaks motiveerivaks faktoriks ei ole. Diagrammid. Skeemid

  3. Indigolapsed - teistmoodi lapsed või lihtsalt lapsed? / Katrin Helend-Aaviku

    Index Scriptorium Estoniae

    Helend-Aaviku, Katrin

    2009-01-01

    Juuru rahvamajas näidati filmiõhtul James Twymani indigolastest rääkivat dokumentaalfilmi "Indigo evolutsioon" (USA, 2005). Filmi ning Lee Carrolli ja Jan Toberi raamatu "Indigolapsed: uus põlvkond on saabunud" põhjal järgnenud arutelust indigolastest koos psühholoog Pille Kuldkepi ja Kalev Veskimäega, kellel on soov luua Paidesse vabakool

  4. Uued muutused nõuavad enam selgitustööd / Katrin Saks

    Index Scriptorium Estoniae

    Saks, Katrin, 1956-

    2008-01-01

    Euroopa Liidu otsustest ja nende tähtsusest ning selgitamise vajadusest. Ilmunud ka Koit 22. jaan. 2008, lk. 6, pealkiri kujul: Muutused nõuavad poliitikutelt järjest enam selgitustööd, Meie Maa 22. jaan. 2008, lk. 2 ; Sakala 24. jaan. 2008, lk. 2 ; Valgamaalane 22. jaan. 2008, lk. 2 ; Virumaa Teataja 25. jaan. 2008, lk. 11 ; Lääne Elu 24. jaan. 2008, lk. 2 ; Pärnu Postimees 5. veeb. 2008, lk. 19

  5. Kes kaitseb röövelliku kiirlaenu eest? / Katrin Saks

    Index Scriptorium Estoniae

    Saks, Katrin, 1956-

    2008-01-01

    Kiirlaenudest ja nendega seonduvatest probleemidest Eestis, seaduseelnõust, mis suurendab SMS-laenu võtnute võimalusi kaitsta oma õigusi laenuandjate ees ning olukorra ohjeldamisest Rootsis ja Soomes. Ilmunud ka Pärnu Postimees 31. okt. 2008, lk. 11, pealkiri kujul: kaitse röövelliku kiirlaenu vastu ja tarbijakaitsepoliitika ; Lõunaleht 6. nov. 2008, lk. 4, pealkiri kujul: kes kaitseb röövelliku kiirlaenu eest ehk tarbijakaitsepoliitika lakmustest ; Vali Uudised 7. nov. 2008, lk. 2 ; Harju Ekspress 7. nov. 2008, lk. 8, pealkiri kujul: kes kaitseb röövelliku kiirlaenu vastu ehk tarbijakaitsepoliitika lakmustest ; Türi Rahvaleht 14. nov. 2008, lk. 4 ; Virumaa Teataja 14. nov. 2008, lk. 11, pealkiri kujul: kiirlaenud on test tarbijakaitsepoliitikale ; Kuulutaja 14. nov. 2008, lk. 4, pealkiri kujul: kes kaitseb kiirlaenu vastu ; Vooremaa 18. nov. 2008, lk. 2 ; Sõnumitooja 26. nov. 2008, lk. 2 ; Koit : Tarbijaleht 27. nov. 2008, lk. 10

  6. Ohutusnõuded laste mänguasjadele muutuvad senisest karmimaks / Katrin Saks

    Index Scriptorium Estoniae

    Saks, Katrin, 1956-

    2008-01-01

    Euroopa Komisjoni avaldatud kauaoodatud mänguasjade ohtuse direktiivi eelnõust, mis reguleerib siin müüdavate mängukannide ohutusnõudeid. Ilmunud ka Meie Maa 23. okt. 2008, lk. 2, pealkiri kujul: nõuded laste mänguasjadele muutuvad karmimaks ; Põhjarannik 23. okt. 2008, lk. 2 ; Järva Teataja 25. okt. 2008, lk. 2, pealkiri kujul: lelude ohutusnõuded karmistuvad ; Kuulutaja 24. okt. 2008, lk. 4 ; Oma Saar 6. nov. 2008, lk. 5 ; Pärnu Postimees 7. nov. 2008, lk. 15 ; Valgamaalane 11. nov. 2008, lk. 2

  7. IP Tallinn 2003 - ühendab teadmised ja meelelahutuse / Karen Veidik, Katrin Tedder

    Index Scriptorium Estoniae

    Veidik, Karen

    2003-01-01

    EBSi eestvedamisel toimuvast rahvusvahelisest intensiivprogrammist, mille raames jagatakse üheksa ülikooli tudengitele teadmisi turundusest, läbirääkimise meetoditest ja kultuurieripäradest suhtlemises

  8. Anti-SEMA4D Monoclonal Antibody VX15/2503 With Nivolumab or Ipilimumab in Treating Patients With Stage III or IV Melanoma

    Science.gov (United States)

    2018-04-26

    Metastatic Melanoma; Stage III Cutaneous Melanoma AJCC v7; Stage IIIA Cutaneous Melanoma AJCC v7; Stage IIIB Cutaneous Melanoma AJCC v7; Stage IIIC Cutaneous Melanoma AJCC v7; Stage IV Cutaneous Melanoma AJCC v6 and v7

  9. Transient downregulation of Sema3A mRNA in a rat model for temporal lobe epilepsy. A novel molecular event potentially contributing to mossy fiber sprouting

    NARCIS (Netherlands)

    Holtmaat, Anthony J D G; Gorter, Jan A; de Wit, Joris; Tolner, Else A; Spijker, Sabine; Giger, Roman J; Lopes da Silva, Fernando H; Verhaagen, J.

    Mossy fiber sprouting (MFS) in the hippocampal dentate gyrus is thought to play a critical role in the hyperexcitability of the hippocampus in temporal lobe epilepsy patients. The composition of molecular signals that is needed to direct this sprouting response has not yet been elucidated to a great

  10. "Ega need loteriivõidud meile taevast alla ei kuku" : Eesti Kooli jõulupidu pole enem mägede taga / Katrin Käärik ; foto: Katrin Käärik

    Index Scriptorium Estoniae

    Käärik, Katrin, 1950-

    2006-01-01

    lapsevanemad Tiina Baugus-Hörnstam, Aime Mölder ja Mart Klaar on need, kes on võtnud Stockholmi Eesti Kooli jõululoterii korraldamise töö ja rõõmu endi kanda. Annetamise võimalustest ja tähtaegadest

  11. Peidetud mõte : Euroopa portselanfiguuride tähendusest / Kersti Kuldna-Türkson ; tõlk. Katrin Kivimaa

    Index Scriptorium Estoniae

    Kuldna-Türkson, Kersti

    2005-01-01

    Esemete funktsioonide ja sümboolsete tähenduste teisenemisest sõltuvalt elulaadist ja keskkonnast. 18.-20. saj. portselanfiguuridest Kadrioru Kunstimuuseumi ja Mikkeli muuseumi kogude põhjal - figuraalsed lauakaunistused, realistlikud kompositsioonid, sari "Venemaa rahvad", 20. saj. vene agitportselan. Portselanitööstus Euroopas

  12. "Jonas, derefter Katrine og Sebastian": En enkel metode til at lære alle de studerendes navne

    DEFF Research Database (Denmark)

    Jørgensen, Anker Helms

    2012-01-01

    Denne artikel præsenterer en enkel, systematisk metode til at lære alle de studerendes navne i universitetsundervisning. Metoden er ret effektiv: I sidste semester lærte jeg 30 studerendes navne på 1.5 time; det svarer til 3 minutter pr. studerende og 6 minutter pr. uge. Min erfaring viser, at de...

  13. "Jonas, derefter Katrine og Sebastian": En enkel metode til at lære alle de studerendes navne

    DEFF Research Database (Denmark)

    Jørgensen, Anker Helms

    2013-01-01

    Denne artikel præsenterer en enkel, systematisk metode til at lære alle de studerendes navne i universitetsundervisning. Metoden er ret effektiv: I sidste semester lærte jeg 30 studerendes navne på 1.5 time; det svarer til 3 minutter pr. studerende og 6 minutter pr. uge. En empirisk undersøgelse ...

  14. Kohtuasjad in puncto libertatis: isiku staatuse tuvastamise lähtekohad asehaldusaja Eestimaal / Katrin Kello, Hesi Siimets-Gross

    Index Scriptorium Estoniae

    Kello, Katrin

    2017-01-01

    Isiku staatuse (vaba versus pärisori) käsitlemisest Eestimaa provintsi kohtutes 18. sajandi viimasel veerandil. Pärisorjuse tuvastamisest ja päruskuuluvust puudutanud õigusallikatest, asehaldusaegsest (1783-1796) kohtusüsteemist

  15. Kognitiivsete ja metakognitiivsete õpistrateegiate toetamine tehnoloogiaga tõhustatud keeleõppes / Katrin Saks, Äli Leijen

    Index Scriptorium Estoniae

    Saks, Katrin, 1968-

    2015-01-01

    Tehnoloogiliste vahenditega tõhustatud võõrkeelekursuse raames välja töötatud sekkumisest, mis võimaldab õpetajal parimal moel toetada õppijate kognitiivseid ja metakognitiivseid keele- õppestrateegiaid

  16. Hinnatõusuralli. Lõppu ei paista : keskküttesoe 12, elekter koguni 23% kallimaks / Katrin Rohtla

    Index Scriptorium Estoniae

    Rohtla, Katrin, 1966-

    2007-01-01

    Kallinev maagaas kergitab veel tänavu keskküttesoojuse hinda 12% võrra ja elektrienergia kallineb 23%. Eestit ähvardavast inflatsioonist ja hinnatõusudest. Vt. samas: Gaas kallineb etteaimamatult

  17. Metsikuse jõud ja ilu = The power & beauty of the wild / Mariliis Lilover ; intervjueerinud Katrin Koov

    Index Scriptorium Estoniae

    Lilover, Mariliis

    2015-01-01

    Mariliis Lilover on maailmakodanikust eesti arhitekt, kes praegu elab Lundis ja teeb koostööd sealse teaduspargiga oma loodud iliilil arcitecture nimelises büroos. Intervjuus avab ta oma mõtteid kaasaja ahitektuurist ja disainist. Tehnoloogia annab suure võimaluse minna sinna, kuhu inimteadvus seni pole küündinud. Palju võimsamalt saab rakendada moodsat ehitustehnoloogiat ja sotsiaalvõrgustikke. Kaasaegses arhitektuuris tuleb liikuda tehnoloogia pakutavast esteetilisest sfäärist edasi eetilisse sfääri ning tegelda tõsiste väljakutsetega ühiskonnas. Lähemalt on vaatluse all Mexico City sülem-sild ja Helsingi Länsisatamanpuisto park.

  18. Eluasemeruum ja linnapoliitika : sotsiaalsest eristumisest ja planeerimisest Sampo Ruoppila Tallinna-teemalises väitekirjas (2006) / Katrin Paadam

    Index Scriptorium Estoniae

    Paadam, Katrin

    2006-01-01

    Doktoritööst: Ruoppila, Sampo. Residential differentiation, housing policy and urban planning in the transformation from state socialism to a market economy : the case of Tallinn. Espoo : Helsinki University of Technology, 2006

  19. Development of a rear wall for the KATRIN rear section and investigation of tritium compatibility of rear section components

    Energy Technology Data Exchange (ETDEWEB)

    Schoenung, Kerstin

    2016-01-15

    The aim of the KArlsruhe TRItium Neutrino experiment is to improve the current neutrino mass sensitivity limit to 0.2 eV/c{sup 2} (90%C.L.). For that, the required proof of suitability of several components for a low pressure tritium atmosphere is furnished. In addition, an optical design for an e-gun is developed and the resulting electron rate is calculated. Also, a final Rear Wall with temporally stable and homogeneous work function is developed and characterized within the scope of this thesis.

  20. Development of a Rear Wall for the KATRIN Rear Section and investigation of tritium compatibility of Rear Section components

    OpenAIRE

    Schönung, Kerstin

    2016-01-01

    The aim of the KArlsruhe TRItium Neutrino experiment is to improve the current neutrino mass sensitivity limit to 0.2 eV/c2 (90%C.L.). For that, the required proof of suitability of several components for a low pressure tritium atmosphere is furnished. In addition, an optical design for an e-gun is developed and the resulting electron rate is calculated. Also, a final Rear Wall with temporally stable and homogeneous work function is developed and characterized within the scope of this thesis.

  1. Lasteaiaõpetaja roll laste agressiivse käitumise vähendamisel / Katrin Taurus, Lii Lilleoja

    Index Scriptorium Estoniae

    Taurus, Katrin

    2015-01-01

    Tallinna lasteaiaõpetajate seas läbi viidud uurimusest selgitamaks välja 2-7-aastaste laste agressiivse käitumise tekkepõhjused ning õpetajate poolt kasutatavad abistamismeetodid selle vähendamiseks

  2. Uuriv arhitektuur : intervjuu arhitekt Sten Gromarkiga = Exploring Architecture : Interview with architect Sten Gromark / Sten Gromark ; interv. Katrin Paadam

    Index Scriptorium Estoniae

    Gromark, Sten

    2007-01-01

    Üks toimetajatest ja autoritest 2006. a. Stockholmis ilmunud arhitektuurikogumikust "Utforskande Arkitektur" ("Uuriv arhitektuur"), mille kandev idee on uuriv suhtumine arhitektuuri sotsiaalsetesse ja kultuurilistesse võimalustesse ja võimalikkusesse

  3. Eesti tööjõuturg: paindlik või turvaline ? / Mikk Salu ; kommenteerinud Katrin Jaaksoo

    Index Scriptorium Estoniae

    Salu, Mikk, 1975-

    2010-01-01

    Tartu Ülikooli sotsiaalteaduslike rakendusuuringute keskuse RAKE (töögrupi juht Raul Eamets) ja Poliitikauuringute Keskuse Praxis (töögrupi juht Andres Võrk) poolt läbi viidud tööjõu turvalise paindlikkuse (ingl. k. flexicurity) uuringust. Taani mudel

  4. Alaealine - kuriteo toimepanija : [bakalaureusetöö] / Katrin Sarv ; Akadeemia Nord, õigusteaduskond ; juhendaja: Helve Särgava

    Index Scriptorium Estoniae

    Sarv, Katrin

    2001-01-01

    Alaealiste poolt sooritatud kuritegude üldiseloomustus, võrdlus Läti, Soome ja Rootsiga, alaealiste kuritegevuse põhjused, kuritegevuse vastu võitlemise alused - kriminaalpreventsioon, kuritegevuse profülaktika

  5. Juuremädanike levik on arvatust ulatuslikum / Tiia Drenkhan, Elisabeth Rähn, Katrin Jürimaa ... [jt.

    Index Scriptorium Estoniae

    2014-01-01

    Maaülikooli metsapatoloogia töörühm uuris aastatel 2012-2014, mil määral on viljakad metsakasvukohatüübid juuremädanike poolt kahjustatud. Projekti "Olulisimate juuremädanike tekitajate leviku ja kahjustuse uuring Eestis" läbiviimist toetas KIK

  6. Õpetajate professionaalse arengu uurimine : kuidas muuta eelarvamuslikud tõekspidamised arengupotentsiaaliks / Katrin Poom-Valickis

    Index Scriptorium Estoniae

    Poom-Valickis, Katrin

    2003-01-01

    Õpetajate veendumuste ja tõekspidamiste roll pedagoogilises teadmises. Kutsetõekspidamiste kujunemine ja kujundamine. Täiendkoolitusel osalenud õpetajate seas läbi viidud uuringust metafooride kasutamisest õpetajate eelarvamuslike tõekspidamiste selgitamisel. Uuringus õpetajate arusaamadest ja veendumustest õpetamisel paluti õpetajatel leida metafoor, mis iseloomustaks õpetamist ja õpetaja rolli õpetamisel. Takistavate eelarvamuste muutmine arengupotentsiaaliks

  7. Visionäärid ning disaini hälli kiigutajad Charles ja Ray Eames / Katrin Kask

    Index Scriptorium Estoniae

    Kask, Katrin

    2007-01-01

    Ameerika disainiklassikute Charles (1907-1978) ja Ray Eamesi (1912-1988) disainitud toolidest. Nende oma majast Californias, mis koosneb tehases valmistatud teras-, vineer- ja klaasdetailidest. Filmidest "Ülevaade Metropolitanist" ja "Powers of Ten"

  8. [Kätlin Kätlin. Üks pole ühtegi = One is none] / Katrin Väli

    Index Scriptorium Estoniae

    Väli, Katrin, 1956-

    2008-01-01

    Tutvustus: Kätlin, Kätlin, pseud. Üks pole ühtegi = One is none / Kätlin Kätlin ; [tõlkijad Mika Keränen ja Marina Tervonen ; illustratsioonid: Hanneleele Kaldmaa. Tallinn : Positive Projects], 2008

  9. Mees, kes näinud kõige rohkem moodsaid aedu / Marc Treib ; interv. Triin Ojari, Katrin Koov

    Index Scriptorium Estoniae

    Treib, Marc

    2008-01-01

    Berkeley ülikooli (California) professor Marc Treib räägib maastikuarhitektuurist, maastiku urbanismist, mõistest "kujundatud maastik", moodsa maastikukujunduse uurimisest, uutest suundadest maastiku kujundamisel. Portreefoto intervjueeritavast

  10. Naisekuju nõukogude ja eesti identiteedi kandjana sotsrealistliku maalikunsti ja graafika näitel / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2007-01-01

    Sotsialistliku realismi kaanoni rakendamisega seotud muutustest II maailmasõja järgses eesti kujutavas kunstis - käsitletakse naise kujutamist, tollase ametliku visuaalpropaganda teenistuses olevana, varasemast eesti kunstist laenatud naisekuvandite kaudu edastatud rahvuslikku ja isegi nõukogudevastast kuvandit

  11. Ultra-stable implanted Rb-83/Kr-83m electron sources for the energy scale monitoring in the KATRIN experiment

    Czech Academy of Sciences Publication Activity Database

    Zbořil, Miroslav; Bauer, S.; Beck, M.; Bonn, J.; Dragoun, Otokar; Jakoubek, J.; Johnston, K.; Kovalík, Alojz; Otten, E. W.; Schlosser, K.; Slezák, Martin; Špalek, Antonín; Thummler, T.; Vénos, Drahoslav; Žemlička, J.; Weinheimer, C.

    2013-01-01

    Roč. 8, č. 3 (2013), P03009 ISSN 1748-0221 R&D Projects: GA ČR(CZ) GAP203/12/1896 Institutional support: RVO:61389005 Keywords : lasers * sources * particle-beams * spectrometers Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders Impact factor: 1.526, year: 2013 http://iopscience.iop.org/1748-0221/8/03/P03009/pdf/1748-0221_8_03_P03009.pdf

  12. Krahv Hermann Keyserlingi konflikt eestimaalastest rahvuskaaslastega 1917-1918 / Henning von Wistinghausen ; tõlk. Katrin Kaugver

    Index Scriptorium Estoniae

    Wistinghausen, Henning von

    2004-01-01

    H. Keyserlingi artiklite "Sõja mõttest" ja "Mõningaid vaatepunkte päevaküsimusele" seisukohtadest ja teesidest, mis käsitlesid kultuurifilosoofilisi vaateid Esimesele maailmasõja ja tuleviku olukorra kohta ning Saksamaa rolli antud ajalooetapil. Eestimaa baltisakslaste etteheidetele vastuseks kirjutatud H. Keyserlingi kirjast Eduard Dellingshausenile, kus on ära toodud artiklite kirjutamise motiivid. Vt. ka: Undusk, Jaan. "Viimane baltlane Hermann Keyserling." (Tuna 2003/2). Järg. nr. 4, lk. 66-81

  13. Luksuslik ruum kõigile : vestlus arhitekt Anne Lacatoniga = Luxury space for everyone : interview with Anne Lacaton / intervjueerinud Katrin Paadam

    Index Scriptorium Estoniae

    Lacaton, Anne, 1955-

    2013-01-01

    Prantsuse arhitekt Anne Lacaton oma büroo (Lacaton & Vassal, Frédéric Druot, 2011) linnaehituslikult uuendusliku projekti järgi ümber ehitatud 1960. aastate korterelamust Tour du Bois-le-Prêtre Pariisis, sotsiaalelamute ehitusest Prantsusmaal, 1960.-1970. aastatel ehitatud elamute taaskasutusega seotud probleemidest, rekonstrueerimise kasulikkusest võrreldes elamu lammutamise ja uuesti ehitamisega, linnas elavatele inimestele paremate elamistingimuste loomisest, linnaplaneerimisest

  14. "Rudi" polutshil glavnõi priz

    Index Scriptorium Estoniae

    2006-01-01

    Lastefilm "Ruudi" (stsenaristid Katrin Laur, Aare Toikka, Aarne Mägi : režissöör Katrin Laur : nimiosas lapsnäitleja Paul Oskar Soe) sai Tokyo 14. lastefilmide festivalil Kodomotachino parima mängufilmi auhinna

  15. Grand prix / J. U.

    Index Scriptorium Estoniae

    J. U.

    2006-01-01

    Lastefilm "Ruudi" (stsenaristid Katrin Laur, Aare Toikka, Aarne Mägi : režissöör Katrin Laur : nimiosas lapsnäitleja Paul Oskar Soe) sai Tokyo 14. lastefilmide festivalil Kodomotachino parima mängufilmi auhinna

  16. "Ruudi" võitis Tokyos

    Index Scriptorium Estoniae

    2006-01-01

    Lastefilm "Ruudi" (stsenaristid Katrin Laur, Aare Toikka, Aarne Mägi : režissöör Katrin Laur : nimiosas lapsnäitleja Paul Oskar Soe) sai Tokyo 14. lastefilmide festivalil Kodomotachino parima mängufilmi auhinna

  17. Vormiriietus teeb koolilapse shikiks ja paneb väärikalt käituma / Sandra Maasalu

    Index Scriptorium Estoniae

    Maasalu, Sandra

    2008-01-01

    Eesti koolides kantavatest koolivormidest. Pikemalt Katrin Kivi disainitud Tallinna Saksa gümnaasiumi koolivormist ja Tallinna Arte gümnaasiumi koolivormist. Katrin Kivi ja Peeter Kreitzbergi kommentaarid. 8 ill.

  18. Reval Hotel Lietuva Vilniuses : Konstitucijos pr. 20 / Piret Lindpere

    Index Scriptorium Estoniae

    Lindpere, Piret, 1963-

    2004-01-01

    Vilniuse hotelli "Lietuva" renoveerimine. Arhitektuurse projekti koostaja Rootsi arhitektuuribüroo AB SWECO (arhitektid Aare Saks, Nils Palm. Sisekujundus: Vaikla Disain AS (Katrin ja Argo Vaikla, Liis Lindvere, Peeter Loo). Kommenteerivad Argo ja Katrin Vaikla. 3 ill

  19. Vene kirjanduse õpik lõhestab kirjanikud headeks ja pahadeks / Vaapo Vaher

    Index Scriptorium Estoniae

    Vaher, Vaapo, 1945-

    2003-01-01

    Arvustus: XX sajandi vene kirjandus. I, Luule / [koostanud Katrin Kalamees ja Maritsa Lens. Tallinn] : Avita, 2002; XX sajandi vene kirjandus. II, Proosa / [koostanud Katrin Kalamees ja Maritsa Lens. Tallinn] : Avita, 2002. Vastukajad: Tuch, Boris. Dva toma oshibok // Estonija (2003) 28. apr., lk. 9 ; Kalamees, Katrin ; Lens, Maritsa. Vastuseid Vaapo Vaheri küsimistele // Eesti Päevaleht (2003) 2. mai, lk. 17

  20. Traumaatilise sündmuse mõju fotograafi loomingule : Margaret Bourke-White'i ja Lee Milleri näitel / Katrin Sarapuu

    Index Scriptorium Estoniae

    Sarapuu, Katrin

    2010-01-01

    Uuritakse kas ja kuidas kajastuvad traumaatilised sündmused ja nende tunnistamine fotograafi loomingus. Selleks analüüsitakse ja võrreldakse mõlema fotograafi sõjaeelseid ja -aegseid töid ning sõjajärgsetele koonduslaagrite külastustele eelnenud ja järgnevat loomingut

  1. Mitteresidendi tulu maksustamine kehtivas õiguses : [bakalaureusetöö] / Katrin Rehemägi ; Akadeemia Nord, õigusteaduskond ; juhendaja: Liia Kubja, konsultant: Rainer Osanik

    Index Scriptorium Estoniae

    Rehemägi, Katrin

    2001-01-01

    Maksuõiguse teoreetilised alused, mitteresidendi tulu maksustamine tulumaksuseaduse järgi, rahvusvahelise topeltmaksustamise vältimise võimalused, Eesti seadusandluse vajalikud muudatused ühinemisel Euroopa Liiduga

  2. Professional preparation of teachers - problems and possibilities. The Estonian case / Katrin Poom-Valickis, Ülle Saarits, Helle Sikka... [jt.

    Index Scriptorium Estoniae

    2008-01-01

    Artikkel kirjeldab õpetajakoolituse olukorda Eestis aastal 2003. Aineõpetajate, klassiõpetajate ja koolieelsete lasteasutuste õpetajate ettevalmistusest Tallinna Ülikoolis ning nende karjääriperspektiive tööturul

  3. Üleminek riigikeelsele gümnaasiumiõppele : vilistlaste seisukohtade Q-metodoloogiline diskursusanalüüs / Anu Masso, Katrin Kello, Valeria Jakobson

    Index Scriptorium Estoniae

    Masso, Anu, 1977-

    2013-01-01

    Keskendutakse diskursustele, mis on seotud riigikeelsele gümnaasiumiõppele üleminekuga senistes vene õppekeelega koolides. Uuring põhineb Tallinnas, Tartus, Ida-Virumaal ja Lätis läbi viidud Q-metodoloogilistel intervjuudel

  4. Järgmise nädala lõpul peetakse Tallinnas... / Katrin Kivimaa ; intervjueerinud R[eet] V[arblane

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2011-01-01

    27. ja 28. mail Tallinnas Eesti Kunstiakadeemia Rüütelkonna hoones toimuvast rahvusvahelisest sümpoosionist "Common Differences: Issues for Feminist Curating in Post-Socialist Europe" ("Ühised erinevused: feministlik kuraatoripraktika postsotsialistlikus Euroopas")

  5. Everything should be made as simple as possible, but not simpler ehk kuidas protsesside lihtsustamine võib maksimeerida ettevõtja kasu / Katrin Avloi

    Index Scriptorium Estoniae

    Avloi, Katrin

    2013-01-01

    Uuest ettevõtete elektroonilisest andmevahetuskanalist Danske LiveGate. Näiteid, milliste pangateenuste kasutamist Danske LiveGate võimaldab ning kuidas protsesside automatiseerimine integreeritud lahenduse kaudu ettevõttele kasu toob

  6. Turistlik eskapism ja sümfoonilised variatsioonid : Tallinna vanalinn vaatefilmides 1960.-1970. aastail / Eva Näripea ; tõlk. Katrin Kivimaa

    Index Scriptorium Estoniae

    Näripea, Eva

    2005-01-01

    Filmid "Toompea" (režissöör Valeri Blinov, Eesti Telefilm, 1977), "Tallinna mosaiik" (režissöör Andrei Dobrovolski, Tallinnfilm, 1967), "Pikk tänav" (režissöör Hans Roosipuu, Tallinnfilm, 1966) ning "Tallinna saladused" (režissöör Ülo Tambek, Tallinnfilm, 1967)

  7. Maarjamäe tallihoone äratamine = Waking of the Maarjamäe stables / Jaak Huimerind, Tarmo Piirmets ; intervjueerinud Katrin Koov

    Index Scriptorium Estoniae

    Huimerind, Jaak, 1957-

    2015-01-01

    Intervjuu arhitekt Jaak Huimerinnaga ja sisearhitekt Tarmo Piirmetsaga Maarjamäe suvemõisa tallihoone restaureerimisest, millest sai Eesti Ajaloomuuseumi näitusteruum. Arhitektuur: Jaak Huimerind, Kadri Viltrop, Stuudio Paralleel. Sisearhitektuur: Tarmo Piirmets, PINK. Valmimisaasta: 2014

  8. Õpetaja professionaalse rolli internaliseerimise hindamine õpetajakoolituse esmaõppe üliõpilaste hulgas / Äli Leijen, Katrin Kullasepp, Aivar Ots

    Index Scriptorium Estoniae

    Leijen, Äli, 1979-

    2013-01-01

    Aineõpetaja magistriõppe üliõpilaste seas läbi viidud uurimusest, milles vaadeldakse, kuidas üliõpilased koordineerivad personaalset ja professionaalset mina-positsiooni erialaste ambivalentsete olukordade kontekstis

  9. Surmanuhtlus kõrgeima võimaliku karistusmäärana : [bakalaureusetöö] / Katrin Roosmaa ; Tartu Ülikool, õigusteaduskond ; juhendaja: Silvia Kaugia

    Index Scriptorium Estoniae

    Roosmaa, Katrin, 1984-

    2007-01-01

    Surmanuhtluse olemus ja selle karistusliigiga sanktsioneeritud teod Eestis lähiminevikus, surmanuhtluse määramine ja täideviimine kuni 1998. a.-ni, surmanuhtluse kaotamise direktiiv ning seda toetavad ja mittetoetavad riigid, levinumad poolt- ja vastuargumendid, Eesti elanikkonna suhtumine

  10. Novice teachers`professional development across their induction year = Algajate õpetajate professionaalne areng kutseaastal : parim doktoritöö sotsiaalteaduste valdkonnas / Katrin Poom-Valickis

    Index Scriptorium Estoniae

    Poom-Valickis, Katrin, 1969-

    2009-01-01

    Doktoritöö eesmärk oli analüüsida algaja õpetaja professionaalset arengut kutseaastal. Uurimuse ülesanne oli kirjeldada ja analüüsida algaja õpetaja hinnanguid oma kutsealasele arengule ning õpetama õppimise kogemustele esimesel tööaastal

  11. Ettevõtte ühiskondlik vastutus ja huvigruppide kaasamine - ettevõtetes loodava sotsiaalkapitali alus / Katrin Tamm, Triin Noorkõiv

    Index Scriptorium Estoniae

    Tamm, Katrin

    2006-01-01

    Ettevõtte ühiskondlikust vastutusest ja rollist ühiskonnas, sotsiaalkapitali käsitlusest ettevõtete kontekstis, ettevõtte ühiskondliku vastutuse ning huvigruppide kaasamise panusest sotsiaalkapitali suurendamisse. Skeemid. Tabelid

  12. Kartulisortide pikaajaline säilitamine in vitro ja säilikute kasutamise võimalused nišitoodeteks / Viive Rosenberg, Katrin Kotkas

    Index Scriptorium Estoniae

    Rosenberg, Viive, 1943-

    2015-01-01

    In vitro säilitamine võimaldab koguda sorte ja rahvaaretisi, neid pikaajaliselt säilitada väliskeskonna mõjutuste eest kaitstuna ning tagab võimaluse säilikuid paljundada ja kasvatada gurmeesortidena turustamiseks

  13. Näitleja Anti Reinthal : "Kui sa just surnud ei ole, siis mängid lõpuni!" / Katrin Rohtla

    Index Scriptorium Estoniae

    Rohtla, Katrin, 1966-

    2007-01-01

    Viinistu kunstimuuseumis etenduva Eesti Draamateatri suvelavastuse "Sürrealistid" 30. juuni etenduses vigastas näitleja raskelt oma reielihast kuid mängis lõpuni. Lisaks Mait Malmsteni kommentaar "Malmsten : "Esimene vaatus mängiti fantaasia abil" ja vaataja arvamus : "Publiku pettis ära"

  14. Õiguslikud väljakutsed audiovisuaalsete teoste kasutamisel kaabellevivõrgus : [magistritöö] / Katrin Kaljuvee ; Tartu Ülikool, õigusteaduskond ; juhendaja: Aleksei Kelli

    Index Scriptorium Estoniae

    Kaljuvee, Katrin, 1982-

    2013-01-01

    Audiovisuaalsetest teostest autoriõigusliku kaitse objektina, autori varalistest õigustest ja nende teostamisest audiovisuaalsete teoste puhul, autoritasude määradest ja tasu maksmise mehhanismidest

  15. Review: Katrin Döveling (2005. Emotionen – Medien – Gemeinschaft. Eine kommunikationssoziologische Analyse [Emotions—Media—Society. A Communication-Sociological Analysis

    Directory of Open Access Journals (Sweden)

    Sascha Demarmels

    2007-09-01

    Full Text Available The goal of this book is it to take a first step in the interdisciplinary elaboration of the theory of emotions in the media. Theories of media and communication sciences are linked to theories from sociology, and pre-existing instruments are further developed. A case study involving group-specific reporting is used to test the resulting theory in practice. Methodologically, qualitative content analysis is used successfully, and both theory and practical implementation are done well. But the book shows also the boundaries of the interdisciplinary working process, present whenever the boundaries of individual knowledge are reached. URN: urn:nbn:de:0114-fqs0703286

  16. Ostsillaatori stabiilsus stohhastilise resonantsi korral = Stability of an oscillator in the case of stochastic resonance : I koht magistritööde kategoorias / Katrin Laas

    Index Scriptorium Estoniae

    Laas, Katrin

    2009-01-01

    Töö eesmärgiks on leida, kuidas sõltub harmoonilise jõu poolt võnkuma pandud ostsillaatoris ilmnev stohhastiline resonants keskkonna mittetasakaaluliste fluktuatsioonide parameetritest ning analüüsida stohhastilise ostsillaatori stabiilsust

  17. Differential endothelial transcriptomics identifies semaphorin 3G as a vascular class 3 semaphorin.

    Science.gov (United States)

    Kutschera, Simone; Weber, Holger; Weick, Anja; De Smet, Frederik; Genove, Guillem; Takemoto, Minoru; Prahst, Claudia; Riedel, Maria; Mikelis, Constantinos; Baulande, Sylvain; Champseix, Catherine; Kummerer, Petra; Conseiller, Emmanuel; Multon, Marie-Christine; Heroult, Melanie; Bicknell, Roy; Carmeliet, Peter; Betsholtz, Christer; Augustin, Hellmut G

    2011-01-01

    To characterize the role of a vascular-expressed class 3 semaphorin (semaphorin 3G [Sema3G]). Semaphorins have been identified as axon guidance molecules. Yet, they have more recently also been characterized as attractive and repulsive regulators of angiogenesis. Through a transcriptomic screen, we identified Sema3G as a molecule of angiogenic endothelial cells. Sema3G-deficient mice are viable and exhibit no overt vascular phenotype. Yet, LacZ expression in the Sema3G locus revealed intense arterial vascular staining in the angiogenic vasculature, starting at E9.5, which was detectable throughout adolescence and downregulated in adult vasculature. Sema3G is expressed as a full-length 100-kDa secreted molecule that is processed by furin proteases to yield 95- and a 65-kDa Sema domain-containing subunits. Full-length Sema3G binds to NP2, whereas processed Sema3G binds to NP1 and NP2. Expression profiling and cellular experiments identified autocrine effects of Sema3G on endothelial cells and paracrine effects on smooth muscle cells. Although the mouse knockout phenotype suggests compensatory mechanisms, the experiments identify Sema3G as a primarily endothelial cell-expressed class 3 semaphorin that controls endothelial and smooth muscle cell functions in autocrine and paracrine manners, respectively.

  18. mTORC1 is a critical mediator of oncogenic Semaphorin3A signaling

    Energy Technology Data Exchange (ETDEWEB)

    Yamada, Daisuke; Kawahara, Kohichi; Maeda, Takehiko, E-mail: maeda@nupals.ac.jp

    2016-08-05

    Aberration of signaling pathways by genetic mutations or alterations in the surrounding tissue environments can result in tumor development or metastasis. However, signaling molecules responsible for these processes have not been completely elucidated. Here, we used mouse Lewis lung carcinoma cells (LLC) to explore the mechanism by which the oncogenic activity of Semaphorin3A (Sema3A) signaling is regulated. Sema3A knockdown by shRNA did not affect apoptosis, but decreased cell proliferation in LLCs; both the mammalian target of rapamycin complex 1 (mTORC1) level and glycolytic activity were also decreased. In addition, Sema3A knockdown sensitized cells to inhibition of oxidative phosphorylation by oligomycin, but conferred resistance to decreased cell viability induced by glucose starvation. Furthermore, recombinant SEMA3A rescued the attenuation of cell proliferation and glycolytic activity in LLCs after Sema3A knockdown, whereas mTORC1 inhibition by rapamycin completely counteracted this effect. These results demonstrate that Sema3A signaling exerts its oncogenic effect by promoting an mTORC1-mediated metabolic shift from oxidative phosphorylation to aerobic glycolysis. -- Highlights: •Sema3A knockdown decreased proliferation of Lewis lung carcinoma cells (LLCs). •Sema3A knockdown decreased mTORC1 levels and glycolytic activity in LLCs. •Sema3A knockdown sensitized cells to inhibition of oxidative phosphorylation. •Sema3A promotes shift from oxidative phosphorylation to aerobic glycolysis via mTORC1.

  19. Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells.

    Science.gov (United States)

    Duan, Yuntao; Wang, Shih-Hsiu; Song, Juan; Mironova, Yevgeniya; Ming, Guo-li; Kolodkin, Alex L; Giger, Roman J

    2014-10-14

    Human SEMAPHORIN 5A (SEMA5A) is an autism susceptibility gene; however, its function in brain development is unknown. In this study, we show that mouse Sema5A negatively regulates synaptogenesis in early, developmentally born, hippocampal dentate granule cells (GCs). Sema5A is strongly expressed by GCs and regulates dendritic spine density in a cell-autonomous manner. In the adult mouse brain, newly born Sema5A-/- GCs show an increase in dendritic spine density and increased AMPA-type synaptic responses. Sema5A signals through PlexinA2 co-expressed by GCs, and the PlexinA2-RasGAP activity is necessary to suppress spinogenesis. Like Sema5A-/- mutants, PlexinA2-/- mice show an increase in GC glutamatergic synapses, and we show that Sema5A and PlexinA2 genetically interact with respect to GC spine phenotypes. Sema5A-/- mice display deficits in social interaction, a hallmark of autism-spectrum-disorders. These experiments identify novel intra-dendritic Sema5A/PlexinA2 interactions that inhibit excitatory synapse formation in developmentally born and adult-born GCs, and they provide support for SEMA5A contributions to autism-spectrum-disorders.

  20. The axonal guidance cue semaphorin 3C contributes to alveolar growth and repair.

    Directory of Open Access Journals (Sweden)

    Arul Vadivel

    Full Text Available Lung diseases characterized by alveolar damage such as bronchopulmonary dysplasia (BPD in premature infants and emphysema lack efficient treatments. Understanding the mechanisms contributing to normal and impaired alveolar growth and repair may identify new therapeutic targets for these lung diseases. Axonal guidance cues are molecules that guide the outgrowth of axons. Amongst these axonal guidance cues, members of the Semaphorin family, in particular Semaphorin 3C (Sema3C, contribute to early lung branching morphogenesis. The role of Sema3C during alveolar growth and repair is unknown. We hypothesized that Sema3C promotes alveolar development and repair. In vivo Sema3C knock down using intranasal siRNA during the postnatal stage of alveolar development in rats caused significant air space enlargement reminiscent of BPD. Sema3C knock down was associated with increased TLR3 expression and lung inflammatory cells influx. In a model of O2-induced arrested alveolar growth in newborn rats mimicking BPD, air space enlargement was associated with decreased lung Sema3C mRNA expression. In vitro, Sema3C treatment preserved alveolar epithelial cell viability in hyperoxia and accelerated alveolar epithelial cell wound healing. Sema3C preserved lung microvascular endothelial cell vascular network formation in vitro under hyperoxic conditions. In vivo, Sema3C treatment of hyperoxic rats decreased lung neutrophil influx and preserved alveolar and lung vascular growth. Sema3C also preserved lung plexinA2 and Sema3C expression, alveolar epithelial cell proliferation and decreased lung apoptosis. In conclusion, the axonal guidance cue Sema3C promotes normal alveolar growth and may be worthwhile further investigating as a potential therapeutic target for lung repair.

  1. Changes in expression of Class 3 Semaphorins and their receptors during development of the rat retina and superior colliculus.

    Science.gov (United States)

    Sharma, Anil; LeVaillant, Chrisna J; Plant, Giles W; Harvey, Alan R

    2014-07-26

    Members of the Semaphorin 3 family (Sema3s) influence the development of the central nervous system, and some are implicated in regulating aspects of visual system development. However, we lack information about the timing of expression of the Sema3s with respect to different developmental epochs in the mammalian visual system. In this time-course study in the rat, we document for the first time changes in the expression of RNAs for the majority of Class 3 Semaphorins (Sema3s) and their receptor components during the development of the rat retina and superior colliculus (SC). During retinal development, transcript levels changed for all of the Sema3s examined, as well as Nrp2, Plxna2, Plxna3, and Plxna4a. In the SC there were also changes in transcript levels for all Sema3s tested, as well as Nrp1, Nrp2, Plxna1, Plxna2, Plxna3, and Plxna4a. These changes correlate with well-established epochs, and our data suggest that the Sema3s could influence retinal ganglion cell (RGC) apoptosis, patterning and connectivity in the maturing retina and SC, and perhaps guidance of RGC and cortical axons in the SC. Functionally we found that SEMA3A, SEMA3C, SEMA3E, and SEMA3F proteins collapsed purified postnatal day 1 RGC growth cones in vitro. Significantly this is a developmental stage when RGCs are growing into and within the SC and are exposed to Sema3 ligands. These new data describing the overall temporal regulation of Sema3 expression in the rat retina and SC provide a platform for further work characterising the functional impact of these proteins on the development and maturation of mammalian visual pathways.

  2. Regulation of semaphorin 4D expression and cell proliferation of ovarian cancer by ERalpha and ERbeta

    Directory of Open Access Journals (Sweden)

    Y. Liu

    Full Text Available Ovarian cancer is one of the most common malignancies in women. Semaphorin 4D (sema 4D is involved in the progress of multiple cancers. In the presence of estrogen-like ligands, estrogen receptors (ERα and ERβ participate in the progress of breast and ovarian cancers by transcriptional regulation. The aim of the study was to investigate the role of sema 4D and elucidate the regulatory pattern of ERα and ERβ on sema 4D expression in ovarian cancers. Sema 4D levels were up-regulated in ovarian cancer SKOV-3 cells. Patients with malignant ovarian cancers had significantly higher sema 4D levels than controls, suggesting an oncogene role of sema 4D in ovarian cancer. ERα expressions were up-regulated in SKOV-3 cells compared with normal ovarian IOSE80 epithelial cells. Conversely, down-regulation of ERβ was observed in SKOV-3 cells. Forced over-expression of ERα and ERβ in SKOV-3 cells was manipulated to establish ERα+ and ERβ+ SKOV-3 cell lines. Incubation of ERα+ SKOV-3 cells with ERs agonist 17β-estradiol (E2 significantly enhanced sema 4D expression and rate of cell proliferation. Incubated with E2, ERβ+ SKOV-3 cells showed lower sema 4D expression and cell proliferation. Blocking ERα and ERβ activities with ICI182-780 inhibitor, sema 4D expressions and cell proliferation of ERα+ and ERβ+ SKOV-3 cells were recovered to control levels. Taken together, the data showed that sema 4D expression was positively correlated with the progress of ovarian cancer. ERα positively regulated sema 4D expression and accelerated cell proliferation. ERβ negatively regulated sema 4D expression and inhibited cell multiplication.

  3. Oskus kuulata / Ellu Maar

    Index Scriptorium Estoniae

    Maar, Ellu

    2007-01-01

    Clare Charnley näitus "Keelte and" Hobusepea galeriis kuni 17. XII. Projektis osalevad kaaskunstnikud, Eestist Katrin Kivimaa. Avamisel esitleti raamatut "So communications : translating each other's words"

  4. Plaadid / Liina Valdre, Erik Aru, Tiiu Laks...[jt.

    Index Scriptorium Estoniae

    2007-01-01

    Uutest heliplaatidest Dylan Donkin "Food For Thoughtlessness", Kreatiivmootor "Irratsionaalne", Coco Electrik "Army Behind The Sun", Marc Collin featuring Katrine Ottosen & Valente "Two For The Road", Korn "Untitled"

  5. Eduard Tubina 100. sünniaastapäeva puhul toimus Stockholmis suur mälestuskontsert / Hilma Nerep-Mossin ; fotod: Karin Mickelsson

    Index Scriptorium Estoniae

    Nerep-Mossin, Hilma

    2005-01-01

    17. aprillil 2005 Stockholmi Soome Kirikus toimunud kontserdi muusikaarvustus. Esinesid Stockholmi Eesti Segakoor, Projektmeeskoor E. Tubin 100, laulusolistid Katrin Meerits, Liine Carlsson ja Mikko Pulkkinen

  6. Narva osales turismimesil Leningradi oblasti boksis / Tanel Mazur

    Index Scriptorium Estoniae

    Mazur, Tanel, 1971-

    2008-01-01

    Ilmunud ka: Narva Postiljon 26. jaan. lk. 1. Narva linnavalitsuse turismispetsialist Katrin Liblik põhjendab, miks osales Narva Helsingis toimunud turismimessil "Matka 2008" Leningradi oblasti boksis

  7. "Tallinna kirikurenessanss" valis logo

    Index Scriptorium Estoniae

    2002-01-01

    Katrin Terno logo, millel on kujutatud Aleksander Nevski katedraali, Oleviste ja Tallinna toomkiriku torni siluett, valiti Tallinna kirikute restaureerimise projekti "Tallinna kirikurenessanss" sümboliks

  8. Semaphorin7A promotes tumor growth and exerts a pro-angiogenic effect in macrophages of mammary tumor-bearing mice

    Directory of Open Access Journals (Sweden)

    Ramon eGarcia-Areas

    2014-02-01

    Full Text Available Semaphorins, a large family of molecules involved in the axonal guidance and development of the nervous system, have been recently shown to have both angiogenic and anti-angiogenic properties. Specifically, semaphorin 7A (SEMA7A has been reported to have a chemotactic activity in neurogenesis, and to be an immune modulator via it binding to α1β1integrins. Additionally, SEMA7A has been shown to promote chemotaxis of monocytes, inducing them to produce proinflammatory mediators. In this study we explored the role of SEMA7A in the tumoral context. We show that SEMA7A is highly expressed by DA-3 murine mammary tumor cells in comparison to normal mammary cells (EpH4, and that peritoneal macrophages from mammary tumor-bearing mice also express SEMA7A at higher levels compared to peritoneal macrophages derived from normal control mice. We also show that murine macrophages treated with recombinant murine SEMA7A significantly increased their expression of proangiogenic molecules, such as CXCL2/MIP-2. Gene silencing of SEMA7A in peritoneal elicited macrophages from DA-3 tumor-bearing mice resulted in decreased CXCL2 expression. Mice implanted with SEMA7A silenced tumor cells showed decreased angiogenesis in the tumors compared to the wild type tumors. Furthermore, peritoneal elicited macrophages from mice bearing SEMA7A-silenced tumors produce significantly (p< 0.01 lower levels of angiogenic proteins, such as MIP-2, CXCL1 and MMP-9, compared to macrophages from control DA-3 mammary tumors. We postulate that SEMA7A derived from mammary carcinomas may serve as a monocyte chemoattractant and skew monocytes into a pro-tumorigenic phenotype. A putative relationship between tumor-derived SEMA7A and monocytes could prove valuable in establishing new research avenues towards unraveling important tumor-host immune interactions in breast cancer patients.

  9. Autocrine Semaphorin3A signaling is essential for the maintenance of stem-like cells in lung cancer

    International Nuclear Information System (INIS)

    Yamada, Daisuke; Takahashi, Kensuke; Kawahara, Kohichi; Maeda, Takehiko

    2016-01-01

    Cancer stem-like cells (CSCs) exist in tumor tissues composed of heterogeneous cell population and are characterized by their self-renewal capacity and tumorigenicity. Many studies demonstrate that eradication of CSCs prevents development and recurrences of tumor; yet, molecules critical for the maintenance of CSCs have not been completely understood. We previously reported that Semaphorin3A (Sema3a) knockdown suppressed the tumorigenicity and proliferative capacity of Lewis lung carcinoma (LLC) cells. Therefore, we identified Sema3a as an essential factor for the establishment or maintenance of CSCs derived from LLC (LLC-stem cell). shRNA against Sema3a was introduced into LLC cells to establish a LLC-stem cell line and its effects on tumorigenesis, sphere formation, and mTORC1 activity were tested. Sema3a knockdown completely abolished tumorigenicity and the sphere-formation and self-renewal ability of LLC-stem cells. The Sema3a knockdown was also associated with decreased expression of mRNA for stem cell markers. The self-renewal ability abolished by Sema3a knockdown could not be recovered by exogenous addition of recombinant SEMA3A. In addition, the activity of mammalian target of rapamycin complex 1 (mTORC1) and the expression of its substrate p70S6K1 were also decreased. These results demonstrate that Sema3a is a potential therapeutic target in eradication of CSCs. - Highlights: • Sema3a enhances tumorigenic capacity of cancer stem-like cells. • Sema3a is essential for the maintenance of cancer stem-like cells. • Sema3a can be a therapeutic target to eradicate cancer stem-like cells.

  10. Urinary semaphorin 3A correlates with diabetic proteinuria and mediates diabetic nephropathy and associated inflammation in mice

    NARCIS (Netherlands)

    Mohamed, Riyaz; Ranganathan, Punithavathi; Jayakumar, Calpurnia; Nauta, Ferdau L.; Gansevoort, Ron T.; Weintraub, Neal L.; Brands, Michael; Ramesh, Ganesan

    2014-01-01

    Semaphorin 3A (sema3A) was recently identified as an early diagnostic biomarker of acute kidney injury. However, its role as a biomarker and/or mediator of chronic kidney disease (CKD) related to diabetic nephropathy is unknown. We examined the expression of sema3A in diabetic animal models and in

  11. Semaphorin7A and its receptors: pleiotropic regulators of immune cell function, bone homeostasis, and neural development.

    Science.gov (United States)

    Jongbloets, Bart C; Ramakers, Geert M J; Pasterkamp, R Jeroen

    2013-03-01

    Semaphorins form a large, evolutionary conserved family of cellular guidance signals. The semaphorin family contains several secreted and transmembrane proteins, but only one GPI-anchored member, Semaphorin7A (Sema7A). Although originally identified in immune cells, as CDw108, Sema7A displays widespread expression outside the immune system. It is therefore not surprising that accumulating evidence supports roles for this protein in a wide variety of biological processes in different organ systems and in disease. Well-characterized biological effects of Sema7A include those during bone and immune cell regulation, neuron migration and neurite growth. These effects are mediated by two receptors, plexinC1 and integrins. However, most of what is known today about Sema7A signaling concerns Sema7A-integrin interactions. Here, we review our current knowledge of Sema7A function and signaling in different organ systems, highlighting commonalities between the cellular effects and signaling pathways activated by Sema7A in different cell types. Furthermore, we discuss a potential role for Sema7A in disease and provide directions for further research. Copyright © 2013 Elsevier Ltd. All rights reserved.

  12. Anatomy of rat semaphorin III/collapsin-1 mRNA expression and relationship to developing nerve tracts during neuroembryogenesis

    NARCIS (Netherlands)

    Giger, Roman J; Wolfer, D P; De Wit, G M; Verhaagen, J

    1996-01-01

    Semaphorin III/collapsin-1 (semaIII/coll-1) is a chemorepellent that exhibits a repulsive effect on growth cones of dorsal root ganglion neurons. To identify structures that express semaIII/coll-1 in developing mammals, we cloned the rat homologue and performed in situ hybridization on embryonic,

  13. A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation.

    Science.gov (United States)

    Ishibashi, Ryoichi; Takemoto, Minoru; Akimoto, Yoshihiro; Ishikawa, Takahiro; He, Peng; Maezawa, Yoshiro; Sakamoto, Kenichi; Tsurutani, Yuya; Ide, Shintaro; Ide, Kana; Kawamura, Harukiyo; Kobayashi, Kazuki; Tokuyama, Hirotake; Tryggvason, Karl; Betsholtz, Christer; Yokote, Koutaro

    2016-05-16

    Kidney diseases including diabetic nephropathy have become huge medical problems, although its precise mechanisms are still far from understood. In order to increase our knowledge about the patho-physiology of kidney, we have previously identified >300 kidney glomerulus-enriched transcripts through large-scale sequencing and microarray profiling of the mouse glomerular transcriptome. One of the glomerulus-specific transcripts identified was semaphorin 3G (Sema3G) which belongs to the semaphorin family. The aim of this study was to analyze both the in vivo and in vitro functions of Sema3G in the kidney. Sema3G was expressed in glomerular podocytes. Although Sema3G knockout mice did not show obvious glomerular defects, ultrastructural analyses revealed partially aberrant podocyte foot processes structures. When these mice were injected with lipopolysaccharide to induce acute inflammation or streptozotocin to induce diabetes, the lack of Sema3G resulted in increased albuminuria. The lack of Sema3G in podocytes also enhanced the expression of inflammatory cytokines including chemokine ligand 2 and interleukin 6. On the other hand, the presence of Sema3G attenuated their expression through the inhibition of lipopolysaccharide-induced Toll like receptor 4 signaling. Taken together, our results surmise that the Sema3G protein is secreted by podocytes and protects podocytes from inflammatory kidney diseases and diabetic nephropathy.

  14. Decreased Expression of Semaphorin3A/Neuropilin-1 Signaling Axis in Apical Periodontitis

    Directory of Open Access Journals (Sweden)

    Ying Lin

    2017-01-01

    Full Text Available Apical periodontitis (AP is a chronic infection of endodontic origin accompanied with bone destruction around the apical region. Semaphorin3A (Sema3A and neuropilin-1 (Nrp1 are regarded as a pair of immune regulators in bone metabolism. In this study, we firstly investigated the expression pattern of Sema3A/Nrp1 in apical periodontitis and its correlation with bone destruction. Using rat animal model, we analysed the level of mandibular bone destruction and the expression of Sema3A/Nrp1 on days 0, 7, 14, 21, 28, and 35 after pulp exposure. In addition, clinical samples from apical periodontitis patients were obtained to analyse the expression of Sema3A/Nrp1. These results indicated that the bone destruction level expanded from days 7 to 35. The number of positive cells and level of mRNA expression of Sema3A/Nrp1 were significantly decreased from days 7 to 35, with a negative correlation with bone destruction. Moreover, expression of Sema3A/Nrp1 in the AP group was reduced compared to the control group of clinical samples. In conclusion, decreased expression of Sema3A/Nrp1 was observed in periapical lesions and is potentially involved in the bone resorption of the periapical area, suggesting that Sema3A/Nrp1 may contribute to the pathological development of apical periodontitis.

  15. Varicose and cheerio collaborate with pebble to mediate semaphorin-1a reverse signaling in Drosophila.

    Science.gov (United States)

    Jeong, Sangyun; Yang, Da-Som; Hong, Young Gi; Mitchell, Sarah P; Brown, Matthew P; Kolodkin, Alex L

    2017-09-26

    The transmembrane semaphorin Sema-1a acts as both a ligand and a receptor to regulate axon-axon repulsion during neural development. Pebble (Pbl), a Rho guanine nucleotide exchange factor, mediates Sema-1a reverse signaling through association with the N-terminal region of the Sema-1a intracellular domain (ICD), resulting in cytoskeletal reorganization. Here, we uncover two additional Sema-1a interacting proteins, varicose (Vari) and cheerio (Cher), each with neuronal functions required for motor axon pathfinding. Vari is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, members of which can serve as scaffolds to organize signaling complexes. Cher is related to actin filament cross-linking proteins that regulate actin cytoskeleton dynamics. The PDZ domain binding motif found in the most C-terminal region of the Sema-1a ICD is necessary for interaction with Vari, but not Cher, indicative of distinct binding modalities. Pbl/Sema-1a-mediated repulsive guidance is potentiated by both vari and cher Genetic analyses further suggest that scaffolding functions of Vari and Cher play an important role in Pbl-mediated Sema-1a reverse signaling. These results define intracellular components critical for signal transduction from the Sema-1a receptor to the cytoskeleton and provide insight into mechanisms underlying semaphorin-induced localized changes in cytoskeletal organization.

  16. Evaluation of a Standardized Extract from Morus alba against α-Glucosidase Inhibitory Effect and Postprandial Antihyperglycemic in Patients with Impaired Glucose Tolerance: A Randomized Double-Blind Clinical Trial

    Science.gov (United States)

    Hwang, Seung Hwan; Li, Hong Mei; Wang, Zhiqiang

    2016-01-01

    To evaluate the antihyperglycemic effect of a standardized extract of the leaves of Morus alba (SEMA), the present study was designed to investigate the α-glucosidase inhibitory effect and acute single oral toxicity as well as evaluate blood glucose reduction in animals and in patients with impaired glucose tolerance in a randomized double-blind clinical trial. SEMA was found to inhibit α-glucosidase at a fourfold higher level than the positive control (acarbose), in a concentration-dependent manner. Moreover, blood glucose concentration was suppressed by SEMA in vivo. Clinical signs and weight changes were observed when conducting an evaluation of the acute toxicity of SEMA through a single-time administration, with clinical observation conducted more than once each day. After administration of the SEMA, observation was for 14 days; all of the animals did not die and did not show any abnormal symptoms. In addition, the inhibitory effects of rice coated with SEMA were evaluated in a group of impaired glucose tolerance patients on postprandial glucose and a group of normal persons, and results showed that SEMA had a clear inhibitory effect on postprandial hyperglycemia in both groups. Overall, SEMA showed excellent potential in the present study as a material for improving postprandial hyperglycemia. PMID:27974904

  17. Anti-proliferative effects of gold nanoparticles functionalized with Semaphorin 3F

    Science.gov (United States)

    Tan, Gamze; Onur, Mehmet Ali

    2017-08-01

    The new vessel formations play a vital role in growth and spread of cancer. Current anti-angiogenic therapies, predominantly based on vascular endothelial growth factor (VEGF) inhibition, can inhibit vascular development; however, they are usually ineffective against the primary tumor occurrence. The aim of this study was to assess anti-angiogenic effects of gold nanoparticles (AuNPs) functionalized with Semaphorin (Sema) 3F protein. The polyethylene glycol (PEG)-coated AuNPs were covalently functionalized with Sema 3F and labeled with the TAMRA fluorescent dye. The effect of the NPs on human umbilical vein endothelial cells (HUVECs) is probed in the way of internalization and viability assays. AuNP-Sema 3F bioconjugates showed great endothelial cell uptake. AuNP-Sema 3F bioconjugates reduced VEGF165-induced endothelial cell proliferation more effectively than Sema 3F alone, suggesting that the therapeutic effects of Sema 3F can be improved by conjugation to AuNPs. Also, no significant toxicity effect was induced by bioconjugates. This is the first study that reports a covalent binding of full length Sema 3F to NPs. The exogenously administration of Sema 3F, which has both anti-angiogenic and anti-tumoral activity, to tumor vasculature via a carrying platform may not only lead to more effective anti-angiogenic treatment but also may make current approach more applicable in clinical use like drug delivery system. [Figure not available: see fulltext.

  18. Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation.

    Science.gov (United States)

    Bouvrée, Karine; Brunet, Isabelle; Del Toro, Raquel; Gordon, Emma; Prahst, Claudia; Cristofaro, Brunella; Mathivet, Thomas; Xu, Yunling; Soueid, Jihane; Fortuna, Vitor; Miura, Nayoki; Aigrot, Marie-Stéphane; Maden, Charlotte H; Ruhrberg, Christiana; Thomas, Jean Léon; Eichmann, Anne

    2012-08-03

    The lymphatic vasculature plays a major role in fluid homeostasis, absorption of dietary lipids, and immune surveillance. Fluid transport depends on the presence of intraluminal valves within lymphatic collectors. Defective formation of lymphatic valves leads to lymphedema, a progressive and debilitating condition for which curative treatments are currently unavailable. How lymphatic valve formation is regulated remains largely unknown. We investigated if the repulsive axon guidance molecule Semaphorin3A (Sema3A) plays a role in lymphatic valve formation. We show that Sema3A mRNA is expressed in lymphatic vessels and that Sema3A protein binds to lymphatic valves expressing the Neuropilin-1 (Nrp1) and PlexinA1 receptors. Using mouse knockout models, we show that Sema3A is selectively required for lymphatic valve formation, via interaction with Nrp1 and PlexinA1. Sema3a(-/-) mice exhibit defects in lymphatic valve formation, which are not due to abnormal lymphatic patterning or sprouting, and mice carrying a mutation in the Sema3A binding site of Nrp1, or deficient for Plxna1, develop lymphatic valve defects similar to those seen in Sema3a(-/-) mice. Our data demonstrate an essential direct function of Sema3A-Nrp1-PlexinA1 signaling in lymphatic valve formation.

  19. Semaphorin 4D induces vaginal epithelial cell apoptosis to control mouse postnatal vaginal tissue remodeling

    Science.gov (United States)

    ITO, TAKUJI; BAI, TAO; TANAKA, TETSUJI; YOSHIDA, KENJI; UEYAMA, TAKASHI; MIYAJIMA, MASAYASU; NEGISHI, TAKAYUKI; KAWASAKI, TAKAHIKO; TAKAMATSU, HYOTA; KIKUTANI, HITOSHI; KUMANOGOH, ATSUSHI; YUKAWA, KAZUNORI

    2015-01-01

    The opening of the mouse vaginal cavity to the skin is a postnatal tissue remodeling process that occurs at approximately five weeks of age for the completion of female genital tract maturation at puberty. The tissue remodeling process is primarily composed of a hormonally triggered apoptotic process predominantly occurring in the epithelium of the distal section of the vaginal cavity. However, the detailed mechanism underlying the apoptotic induction remains to be elucidated. In the present study, it was observed that the majority of BALB/c mice lacking the class 4 semaphorin, semaphorin 4D (Sema4D), developed imperforate vagina and hydrometrocolpos resulting in a perpetually unopened vaginal cavity regardless of a normal estrogen level comparable with that in wild-type (WT) mice. Administration of β-estradiol to infant Sema4D-deficient (Sema4D−/−) mice did not induce precocious vaginal opening, which was observed in WT mice subjected to the same β-estradiol administration, excluding the possibility that the closed vaginal phenotype was due to insufficient estrogen secretion at the time of vaginal opening. In order to assess the role of Sema4D in the postnatal vaginal tissue remodeling process, the expression of Sema4D and its receptor, plexin-B1, was examined as well as the level of apoptosis in the vaginal epithelia of five-week-old WT and Sema4D−/− mice. Immunohistochemical analyses confirmed the localization of Sema4D and plexin-B1 in the mouse vaginal epithelia. Terminal deoxynucleotidyl transferase dUTP nick end labeling assay and immunohistochemistry detecting activated caspase-3 revealed significantly fewer apoptotic cells in situ in the vaginal mucosa of five-week-old Sema4D−/− mice compared with WT mice. The addition of recombinant Sema4D to Sema4D−/− vaginal epithelial cells in culture significantly enhanced apoptosis of the vaginal epithelial cells, demonstrating the apoptosis-inducing activity of Sema4D. The experimental reduction of

  20. Expression of semaphorin 3A in the rat corneal epithelium during wound healing

    International Nuclear Information System (INIS)

    Morishige, Naoyuki; Ko, Ji-Ae; Morita, Yukiko; Nishida, Teruo

    2010-01-01

    The neural guidance protein semaphorin 3A (Sema3A) is expressed in corneal epithelial cells of the adult rat. We have now further investigated the localization of Sema3A in the normal rat corneal epithelium as well as changes in its expression pattern during wound healing after central corneal epithelial debridement. The expression pattern of Sema3A was compared with that of the tight-junction protein zonula occludens-1 (ZO-1), the gap-junction protein connexin43 (Cx43), or the cell proliferation marker Ki67. Immunofluorescence analysis revealed that Sema3A was present predominantly in the membrane of basal and wing cells of the intact corneal epithelium. The expression of Sema3A at the basal side of basal cells was increased in the peripheral epithelium compared with that in the central region. Sema3A was detected in all layers at the leading edge of the migrating corneal epithelium at 6 h after central epithelial debridement. The expression of Sema3A was markedly up-regulated in the basal and lateral membranes of columnar basal cells apparent in the thickened, newly healed epithelium at 1 day after debridement, but it had largely returned to the normal pattern at 3 days after debridement. The expression of ZO-1 was restricted to superficial epithelial cells and remained mostly unchanged during the wound healing process. The expression of Cx43 in basal cells was down-regulated at the leading edge of the migrating epithelium but was stable in the remaining portion of the epithelium. Ki67 was not detected in basal cells of the central epithelium at 1 day after epithelial debridement, when Sema3A was prominently expressed. Immunoblot analysis showed that the abundance of Sema3A in the central cornea was increased 1 day after epithelial debridement, whereas that of ZO-1 or Cx43 remained largely unchanged. This increase in Sema3A expression was accompanied by up-regulation of the Sema3A coreceptor neuropilin-1. Our observations have thus shown that the expression of

  1. Infantile hemangioma-derived stem cells and endothelial cells are inhibited by class 3 semaphorins

    International Nuclear Information System (INIS)

    Nakayama, Hironao; Huang, Lan; Kelly, Ryan P.; Oudenaarden, Clara R.L.; Dagher, Adelle; Hofmann, Nicole A.; Moses, Marsha A.; Bischoff, Joyce; Klagsbrun, Michael

    2015-01-01

    Class 3 semaphorins were discovered as a family of axon guidance molecules, but are now known to be involved in diverse biologic processes. In this study, we investigated the anti-angiogenic potential of SEMA3E and SEMA3F (SEMA3E&F) in infantile hemangioma (IH). IH is a common vascular tumor that involves both vasculogenesis and angiogenesis. Our lab has identified and isolated hemangioma stem cells (HemSC), glucose transporter 1 positive (GLUT1 + ) endothelial cells (designated as GLUT1 sel cells) based on anti-GLUT1 magnetic beads selection and GLUT1-negative endothelial cells (named HemEC). We have shown that these types of cells play important roles in hemangiogenesis. We report here that SEMA3E inhibited HemEC migration and proliferation while SEMA3F was able to suppress the migration and proliferation in all three types of cells. Confocal microscopy showed that stress fibers in HemEC were reduced by SEMA3E&F and that stress fibers in HemSC were decreased by SEMA3F, which led to cytoskeletal collapse and loss of cell motility in both cell types. Additionally, SEMA3E&F were able to inhibit vascular endothelial growth factor (VEGF)-induced sprouts in all three types of cells. Further, SEMA3E&F reduced the level of p-VEGFR2 and its downstream p-ERK in HemEC. These results demonstrate that SEMA3E&F inhibit IH cell proliferation and suppress the angiogenic activities of migration and sprout formation. SEMA3E&F may have therapeutic potential to treat or prevent growth of highly proliferative IH. - Highlights: • SEMA3E&F reduce actin stress fibers and induce cytoskeletal collapse in HemEC. • SEMA3E&F inhibit angiogenic activities of HemEC. • SEMA3E&F can interrupt the VEGF-A-VEGFR2-ERK signaling pathway in HemEC. • Plexin D1 and NRP2 are induced during HemSC/GLUT1 sel -to-EC differentiation

  2. Semaphorin 4D induces vaginal epithelial cell apoptosis to control mouse postnatal vaginal tissue remodeling.

    Science.gov (United States)

    Ito, Takuji; Bai, Tao; Tanaka, Tetsuji; Yoshida, Kenji; Ueyama, Takashi; Miyajima, Masayasu; Negishi, Takayuki; Kawasaki, Takahiko; Takamatsu, Hyota; Kikutani, Hitoshi; Kumanogoh, Atsushi; Yukawa, Kazunori

    2015-02-01

    The opening of the mouse vaginal cavity to the skin is a postnatal tissue remodeling process that occurs at approximately five weeks of age for the completion of female genital tract maturation at puberty. The tissue remodeling process is primarily composed of a hormonally triggered apoptotic process predominantly occurring in the epithelium of the distal section of the vaginal cavity. However, the detailed mechanism underlying the apoptotic induction remains to be elucidated. In the present study, it was observed that the majority of BALB/c mice lacking the class 4 semaphorin, semaphorin 4D (Sema4D), developed imperforate vagina and hydrometrocolpos resulting in a perpetually unopened vaginal cavity regardless of a normal estrogen level comparable with that in wild‑type (WT) mice. Administration of β‑estradiol to infant Sema4D‑deficient (Sema4D‑/‑) mice did not induce precocious vaginal opening, which was observed in WT mice subjected to the same β‑estradiol administration, excluding the possibility that the closed vaginal phenotype was due to insufficient estrogen secretion at the time of vaginal opening. In order to assess the role of Sema4D in the postnatal vaginal tissue remodeling process, the expression of Sema4D and its receptor, plexin‑B1, was examined as well as the level of apoptosis in the vaginal epithelia of five‑week‑old WT and Sema4D‑/‑ mice. Immunohistochemical analyses confirmed the localization of Sema4D and plexin‑B1 in the mouse vaginal epithelia. Terminal deoxynucleotidyl transferase dUTP nick end labeling assay and immunohistochemistry detecting activated caspase‑3 revealed significantly fewer apoptotic cells in situ in the vaginal mucosa of five‑week‑old Sema4D‑/‑ mice compared with WT mice. The addition of recombinant Sema4D to Sema4D‑/‑ vaginal epithelial cells in culture significantly enhanced apoptosis of the vaginal epithelial cells, demonstrating the apoptosis‑inducing activity of Sema4D. The

  3. Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor

    Directory of Open Access Journals (Sweden)

    Keegan Achsah D

    2011-05-01

    Full Text Available Abstract Background Semaphorins were originally identified as molecules regulating a functional activity of axons in the nervous system. Sema4A and Sema4D were the first semaphorins found to be expressed on immune cells and were termed "immune semaphorins". It is known that Sema4A and Sema4D bind Tim-2 and CD72 expressed on leukocytes and PlexinD1 and B1 present on non-immune cells. These neuroimmune semaphorins and their receptors have been shown to play critical roles in many physiological and pathological processes including neuronal development, immune response regulation, cancer, autoimmune, cardiovascular, renal, and infectious diseases. However, the expression and regulation of Sema4A, Sema4D, and their receptors in normal and allergic lungs is undefined. Results Allergen treatment and lung-specific vascular endothelial growth factor (VEGF expression induced asthma-like pathologies in the murine lungs. These experimental models of allergic airway inflammation were used for the expression analysis of immune semaphorins and their receptors employing immunohistochemistry and flow cytometry techniques. We found that besides accessory-like cells, Sema4A was also detected on bronchial epithelial and smooth muscle cells, whereas Sema4D expression was high on immune cells such as T and B lymphocytes. Surprisingly, under inflammation various cell types including macrophages, lymphocytes, and granulocytes in the lung expressed Tim-2, a previously defined marker for Th2 cells. CD72 was found on lung immune, inflammatory, and epithelial cells. Bronchial epithelial cells were positive for both plexins, whereas some endothelial cells selectively expressed Plexin D1. Plexin B1 expression was also detected on lung DC. Both allergen and VEGF upregulated the expression of neuroimmune semaphorins and their receptors in the lung tissue. However, the lung tissue Sema4A-Tim2 expression was rather weak, whereas Sema4D-CD72 ligand-receptor pair was vastly

  4. Infantile hemangioma-derived stem cells and endothelial cells are inhibited by class 3 semaphorins

    Energy Technology Data Exchange (ETDEWEB)

    Nakayama, Hironao [Vascular Biology Program, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States); Department of Surgery, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States); Division of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Toon, Ehime 791-0295 (Japan); Huang, Lan [Vascular Biology Program, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States); Department of Surgery, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States); Kelly, Ryan P.; Oudenaarden, Clara R.L. [Vascular Biology Program, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States); Dagher, Adelle; Hofmann, Nicole A.; Moses, Marsha A. [Vascular Biology Program, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States); Department of Surgery, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States); Bischoff, Joyce, E-mail: joyce.bischoff@childrens.harvard.edu [Vascular Biology Program, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States); Department of Surgery, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States); Klagsbrun, Michael, E-mail: michael.klagsbrun@childrens.harvard.edu [Vascular Biology Program, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States); Department of Surgery, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States); Department of Pathology, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States)

    2015-08-14

    Class 3 semaphorins were discovered as a family of axon guidance molecules, but are now known to be involved in diverse biologic processes. In this study, we investigated the anti-angiogenic potential of SEMA3E and SEMA3F (SEMA3E&F) in infantile hemangioma (IH). IH is a common vascular tumor that involves both vasculogenesis and angiogenesis. Our lab has identified and isolated hemangioma stem cells (HemSC), glucose transporter 1 positive (GLUT1{sup +}) endothelial cells (designated as GLUT1{sup sel} cells) based on anti-GLUT1 magnetic beads selection and GLUT1-negative endothelial cells (named HemEC). We have shown that these types of cells play important roles in hemangiogenesis. We report here that SEMA3E inhibited HemEC migration and proliferation while SEMA3F was able to suppress the migration and proliferation in all three types of cells. Confocal microscopy showed that stress fibers in HemEC were reduced by SEMA3E&F and that stress fibers in HemSC were decreased by SEMA3F, which led to cytoskeletal collapse and loss of cell motility in both cell types. Additionally, SEMA3E&F were able to inhibit vascular endothelial growth factor (VEGF)-induced sprouts in all three types of cells. Further, SEMA3E&F reduced the level of p-VEGFR2 and its downstream p-ERK in HemEC. These results demonstrate that SEMA3E&F inhibit IH cell proliferation and suppress the angiogenic activities of migration and sprout formation. SEMA3E&F may have therapeutic potential to treat or prevent growth of highly proliferative IH. - Highlights: • SEMA3E&F reduce actin stress fibers and induce cytoskeletal collapse in HemEC. • SEMA3E&F inhibit angiogenic activities of HemEC. • SEMA3E&F can interrupt the VEGF-A-VEGFR2-ERK signaling pathway in HemEC. • Plexin D1 and NRP2 are induced during HemSC/GLUT1{sup sel}-to-EC differentiation.

  5. Tekstiilikonverents Hispaanias / Lea Pruuli

    Index Scriptorium Estoniae

    Pruuli, Lea

    1998-01-01

    8. - 16. märtsini Barcelonas ja Madridis European Textile Networki konverentsist. Eesti tekstiilikunstnike delegatsiooni kuulusid Katrin Pere, Signe Kivi, Lylian Meister, Merike Männi, Aune Taamal, Aet Ollisaar, Anne Tootma ja Lea Pruuli. Eesti tekstiilikunstist kõnelesid Signe Kivi, Katrin Pere. K. Pere valiti ETN juhatuse vaatlejaliikmeks.

  6. "Ansip tshmo" kak objekt iskusstva / Nikolai Karajev

    Index Scriptorium Estoniae

    Karajev, Nikolai, 1978-

    2007-01-01

    Briti kunstniku Clare Charnley multimeediainstallatsioon أGift of tongues / keelte andؤ Hobusepea galeriis Tallinnas. Eestipoolseks kaaskunstnikuks projektis on Katrin Kivimaa. Performance'ist أKõneؤ ja alumises galeriis näidatavast videoinstallatsioonist. Clare Charnley ja Katrin Kivimaa koostatud raamatust "So Communication : Translating Each Other's Words"

  7. FIBIT - Fashion is back in Tallinn / Marina Poltavtseva

    Index Scriptorium Estoniae

    Poltavtseva, Marina

    2004-01-01

    Moepäevad FIBIT Viru keskuses. Üks idee algatajaid on moekunstnik Katrin Kuldma. 1. oktoobril näidatakse soome moekunstniku Ritva-Liisa Pohjalaineni kollektsiooni Allergia - From Dreams to the Unique. Teisi moedemonstratsioone, millede stilistideks on Riina Põldroos, Aldo Järvsoo, Tanel Veenre ja Katrin Kuldma. Rõivad on valitud Viru keskuse kauplustest

  8. Eramu Leppneemes = Private residence in Leppneeme

    Index Scriptorium Estoniae

    2011-01-01

    Arhitekt Lembit Torgi poolt projekteeritud eramu sisekujundusest. Sisearhitektid Argo Vaikla, Katrin Vaikla, Mari-Liis Süld (Vaikla Disain). Kabineti puitmööbli ja garderoobi sisustuse projekteeris Vaikla Disain. Loetletud Mari-Liis Sülla tehtud töid ning Argo ja Katrin Vaikla ühiselt tehtud töid

  9. Haabersti vaba aja keskus = Haabersti recreational centre

    Index Scriptorium Estoniae

    2008-01-01

    Haabersti vaba aja keskuse (Ehitajate tee 109A/2, Tallinn) sisekujundusest. Arhitektid: Peeter Pere ja Urmas Muru (AB Muru & Pere). Sisearhitekt: Katrin Kaevats (Salto AB). Katrin Kaevatsist, tema tähtsamad tööd. I-IV korruse plaan, värv. välisvaade, 11 sisevaadet, foto K. Kaevatsist

  10. Kas läheb ka Ruudi tapmiseks? / Kati Murutar

    Index Scriptorium Estoniae

    Murutar, Kati, 1967-

    2006-01-01

    Lastefilm "Ruudi" : stsenaristid Katrin Laur, Aare Toikka, Aarne Mägi : režissöör Katrin Laur : nimiosas lapsnäitleja Paul Oskar Soe : Allfilm - MRP Matila Röhr Productions - Schmidtz Katze Filmkollektiv 2006. Võetud kõne alla ka Peeter Simmi "Kõrini!" ja Peeter Urbla "Stiilipeo" arvustaja meelest teenimatult mahategevad retsensioonid

  11. Eesti lastefilm räägib üksikutest lastest ja üksikutest vanematest / Jürgen Rooste, Marko Martinson

    Index Scriptorium Estoniae

    Rooste, Jürgen, 1979-

    2006-01-01

    Lastefilm "Ruudi" : stsenaristid Katrin Laur, Aare Toikka, Aarne Mägi : režissöör Katrin Laur : nimiosas lapsnäitleja Paul Oskar Soe : produtsent Piret Tibbo-Hudgins : operaator Rein Kotov : kunstnik Toomas Hõrak : Allfilm - MRP Matila Röhr Productions - Schmidtz Katze Filmkollektiv 2006

  12. Pildiseiklusi maal ja merel / Neeme Korv

    Index Scriptorium Estoniae

    Korv, Neeme, 1974-

    2010-01-01

    Arvustus: Hergé, pseud. Kuldsõrgadega krabi / [prantsuse keelest tõlkinud Katrin Kaarep. Tallinn] : Tänapäev, 2010. (Tintini seiklused) ; Hergé, pseud. Must last / [prantsuse keelest tõlkinud Katrin Kaarep. Tallinn] : Tänapäev, 2010. (Tintini seiklused)

  13. Vabariigi Valitsuse istungitesaali mööbel = Furniture for the Estonian Government cabinet's meeting room

    Index Scriptorium Estoniae

    2008-01-01

    Stenbocki Maja istungitesaali (Rahukohtu 3, Tallinn) mööbel. Disainerid: Katrin Vaikla, Argo Vaikla (Vaikla Disain), Liis Tarbe (Torpedo Interior OÜ). Argo ja Katrin Vaiklast, Vaikla Disaini tähtsamad tööd. Liis Tarbest, koostöös Vaikla Disainiga valminud tööd. 6 värv. vaadet, fotod sisearhitektidest

  14. Sirbi tegijad läbi aegade

    Index Scriptorium Estoniae

    2004-01-01

    Toimetaja asetäitjad: Katrin Kivimaa, Reet Varblane jt. Kunst, arhitektuur: Alo Hoidre, Boris Lukats, Ressi Kaera, Jaak Olep, Ike Volkov, Mirjam Peil, Tiina Käesel, Katrin Kivimaa, Vappu Vabar, Reet Varblane, Mari Laaniste. Kunstnikud (arvutikujundus): Tõnu Soo, Ann Gornischeff, Gädvi Kuklase, Piia Ruber. Fotograafid: Solomon Rosenfeldt, Endel Köster, Kalju Suur, Arno Saar, Teet Malsroos

  15. The Role Of Semaphorin 3A In The Skeletal System.

    Science.gov (United States)

    Tang, Peifu; Yin, Pengbin; Lv, Houchen; Zhang, Licheng; Zhang, Lihai

    2015-01-01

    Semaphorin 3A (Sema3A), characterized by a conserved N-terminal "Sema" domain, was originally described as an axon guidance molecule. Recent research indicates that it performs a critical function in the skeletal system. This review highlights recent advances in understanding of the role of Sema3A in the skeletal system as a regulator of bone metabolism and as a potential drug target for bone disease therapy. We summarize Sema3A functions in osteoblastogenesis and osteoclastogenesis, as well as in innervation, and we discuss its multifunctional role in various bone diseases such as osteoporosis and low back pain. Despite limited research in this field, our aim is to promote further understanding of the function of Sema3A in the skeletal system.

  16. Prostate cancer cells induce osteoblastic differentiation via semaphorin 3A.

    Science.gov (United States)

    Liu, Fuzhou; Shen, Weiwei; Qiu, Hao; Hu, Xu; Zhang, Chao; Chu, Tongwei

    2015-03-01

    Prostate cancer metastasis to bone is the second most commonly diagnosed malignant disease among men worldwide. Such metastatic disease is characterized by the presence of osteoblastic bone lesions, and is associated with high rates of mortality. However, the various mechanisms involved in prostate cancer-induced osteoblastic differentiation have not been fully explored. Semaphorin 3A (Sema 3A) is a newly identified regulator of bone metabolism which stimulates differentiation of pre-osteoblastic cells under physiological conditions. We investigated in this study whether prostate cancer cells can mediate osteoblastic activity through Sema 3A. We cultured osteoprogenitor MC3T3-E1 cells in prostate cancer-conditioned medium, and analyzed levels of Sema 3A protein in diverse prostate cancer cell lines to identify cell lines in which Sema 3A production showed a positive correlation with osteo-stimulation. C4-2 cells were stably transfected with Sema 3A short hairpin RNA to further determine whether Sema 3A contributes to the ability of C4-2 cells to induce osteoblastic differentiation. Down-regulation of Sema 3A expression decreased indicators of C4-2 CM-induced osteoblastic differentiation, including alkaline phosphatase production and mineralization. Additionally, silencing or neutralizing Sema 3A in C4-2 cells resulted in diminished β-catenin expression in osteogenitor MC3T3-E1 cells. Our results suggest that prostate cancer-induced osteoblastic differentiation is at least partially mediated by Sema 3A, and may be regulated by the β-catenin signalling pathway. Sema 3A may represent a novel target for treatment of prostate cancer-induced osteoblastic lesions. © 2014 Wiley Periodicals, Inc.

  17. The Estonian Foundation – What is Missing for It to Be A Well-Designed Wealth-Management Vehicle for Local and Foreign High-Net-Worth Individuals? / Katrin Sepp , Urmas Kaarlep

    Index Scriptorium Estoniae

    Sepp, Katrin

    2016-01-01

    Erahuvides sihtasutustest, neile kohalduvast seadusest Eestis ja kohalduva seaduse parendamise ettepanekutest teiste riikide näitel. Erahuvides sihtasutuste kasutamise eesmärkidest ja sellega seonduvatest probleemidest Eesti seadusandluses

  18. A comparative study of commercial free speech and limiting advertising in North America and continental Europe : [teadusmagistritöö] / Katrin Saaremäel-Stoilov ; Tartu Ülikool, õigusteaduskond ; juhendajad: Raul Narits, A. Sajo

    Index Scriptorium Estoniae

    Saaremäel-Stoilov, Katrin

    2003-01-01

    Kaubandusliku sõnavabaduse mõiste, kaubanduslik sõnavabadus ja lastele suunatud ning eksitava reklaami piirangud Ameerika Ühendriikides ja Kanadas, kaubanduslik sõnavabadus Saksamaal ja Eestis, lisaks Euroopa Nõukogu ja Euroopa Liidu vastavad konventsioonid. - Kaitses 22. 08. 2003. a. Tartu Ülikoolis

  19. Tarbija majandushuvide kaitse, tarbijateave ja tarbija esindusõiguse tagamine Eesti ja Euroopa Ühenduse õiguses : [bakalaureusetöö] / Katrin Saaremäel ; Tartu Ülikool, õigusteaduskond ; juhendaja: Raul Narits

    Index Scriptorium Estoniae

    Saaremäel, Katrin

    2000-01-01

    Tarbijaõiguse olemusest, tarbija mõiste, Eesti ja Euroopa Ühenduse tarbijakaitseõigus, tarbija majandushuvide kaitse, tarbijateave, tarbija huvide esindamine.Vt. ka Juridica (2000) nr. 6, lk. 395-401

  20. Lars Noréni uued näidendid, Jeremy Ironsi comeback, Theatertreffen'i näidendite turg, Bonni biennaal ja India / Katrin Talts, Tiia Sippol

    Index Scriptorium Estoniae

    Talts, Katrin

    2006-01-01

    Rootsi näitekirjaniku Lars Noréni kahest uuest näidendist, mida ühendab pealkiri "Terminaal"; Londoni teatris Duke of York esietendunud Sándor Márai romaanil "Küünlad põlevad lõpuni" põhinevast lavastusest "Hõõguvad söed" (dramatiseerija Ch. Hampton, lavastaja M. Blakemore), peaosas Jeremy Irons ; Berliinis 5.-21. maini peetavast teatrifestivalist "Theatertreffen" ; Brightoni festivalist 6.-28. mail ja Bonni biennaalist 13.-21. mail

  1. Leidlikud lahendused : uus elamuehitus Amsterdamis = Enforcing Ingenuity New Housing in Amsterdam / Hans Ibelings ; hollandi keelest tõlk. eesti keelde Katrin Laiapea ja inglise keelde Robyn de Jong-Dalziel

    Index Scriptorium Estoniae

    Ibelings, Hans

    2001-01-01

    Amsterdami kahe elamurajooni planeeringust. Borneo-Sporenburgi (1994-2001) planeeringu tegi Adriaan Geuze ja tema büroo West 8. Kolm hiigelelamut projekteerisid Koen van Velsen, Frits van Dongen ja Kees Christiaanse. Valmimisjärgus IJburgi planeeringu autorid Felix Claus, Frits van Dongen ja Ton Schaap. 13 ill

  2. Ülema vastutus rahvusvahelises õiguses ICTY ja ICTR kohtupraktika näidetel : [magistritöö] / Katrin Värte ; Tartu Ülikool, õigusteaduskond ; juhendaja: René Värk

    Index Scriptorium Estoniae

    Värte, Katrin

    2010-01-01

    Ülema vastutuse olemusest ja selle elementidest, tsiviilülemate vastutusest, otsesest vastutusest versus ülema vastutusest. Endise Jugoslaavia Rahvusvahelise Kriminaaltribunal = ICTY. Rwanda Rahvusvaheline Kriminaaltribunal = ICTR

  3. Isikult vabaduse võtmine põhjendusel, et ta on psüühikahäire tõttu endale või teistele ohtlik / Sten Lind, Katrin Eino

    Index Scriptorium Estoniae

    Lind, Sten, 1979-

    2014-01-01

    Psüühikahäire määratlemine ning isiku ohtlikkus psühhiaatrilise abi seaduse § 11, sotsiaalhoolekande seaduse § 19 ja karistusseadustiku § 86 kontekstis. Riigikohtu lahenditest 3-2-1-81-07 ja 3-2-1-155-13

  4. Mare Tralla : Stories of a "disgusting girl" : küberfeministlik ja trans/natsionaalne tehno-naer = Stories of a "disgusting girl" : cyberfeminist and trans/national techno-laughter / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2007-01-01

    Mare Tralla kunstnikuteest 1990-ndatel performance'i- ja videokunstniku, feministi ning kuraatorina. Tema kunsti iseloomustab ühiskonnakriitika ja eneseirooniline nostalgia ning "väike feministllik revolutsioon ühiskonna harmoonilisema ja õiglasema arengu tarvis". Alates 1996. aastast elab ja tegutseb peamiselt Londonis

  5. Ando Keskküla, kas sa arvad, et 'Interstanding'u'-taolised üritused suudavad kuidagi mõjutada meie praegust tegelikkust ja kui, siis kuidas? / Ando Keskküla ; interv. Katrin Kivimaa

    Index Scriptorium Estoniae

    Keskküla, Ando, 1950-2008

    1999-01-01

    "Interstanding'u" missioon: tõestada, et infoühiskond ei ole ainult e-kaubandus ja kiire kasumi võimalus. Esimese ja teise "Interstanding'u" panus Eestile, kolmanda "Interstanding'u" 'Ülalpool piire' üleskutse.

  6. The axon guidance molecule semaphorin 3F is a negative regulator of tumor progression and proliferation in ileal neuroendocrine tumors

    Science.gov (United States)

    Vercherat, Cécile; Blanc, Martine; Lepinasse, Florian; Gadot, Nicolas; Couderc, Christophe; Poncet, Gilles; Walter, Thomas; Joly, Marie-Odile; Hervieu, Valérie; Scoazec, Jean-Yves; Roche, Colette

    2015-01-01

    Gastro-intestinal neuroendocrine tumors (GI-NETs) are rare neoplasms, frequently metastatic, raising difficult clinical and therapeutic challenges due to a poor knowledge of their biology. As neuroendocrine cells express both epithelial and neural cell markers, we studied the possible involvement in GI-NETs of axon guidance molecules, which have been shown to decrease tumor cell proliferation and metastatic dissemination in several tumor types. We focused on the role of Semaphorin 3F (SEMA3F) in ileal NETs, one of the most frequent subtypes of GI-NETs. SEMA3F expression was detected in normal neuroendocrine cells but was lost in most of human primary tumors and all their metastases. SEMA3F loss of expression was associated with promoter gene methylation. After increasing endogenous SEMA3F levels through stable transfection, enteroendocrine cell lines STC-1 and GluTag showed a reduced proliferation rate in vitro. In two different xenograft mouse models, SEMA3F-overexpressing cells exhibited a reduced ability to form tumors and a hampered liver dissemination potential in vivo. This resulted, at least in part, from the inhibition of mTOR and MAPK signaling pathways. This study demonstrates an anti-tumoral role of SEMA3F in ileal NETs. We thus suggest that SEMA3F and/or its cellular signaling pathway could represent a target for ileal NET therapy. PMID:26447612

  7. Semaphorin-1a is required for Aedes aegypti embryonic nerve cord development.

    Directory of Open Access Journals (Sweden)

    Morgan Haugen

    Full Text Available Although mosquito genome projects have uncovered orthologues of many known developmental regulatory genes, extremely little is known about mosquito development. In this study, the role of semaphorin-1a (sema1a was investigated during vector mosquito embryonic ventral nerve cord development. Expression of sema1a and the plexin A (plexA receptor are detected in the embryonic ventral nerve cords of Aedes aegypti (dengue vector and Anopheles gambiae (malaria vector, suggesting that Sema1a signaling may regulate mosquito nervous system development. Analysis of sema1a function was investigated through siRNA-mediated knockdown in A. aegypti embryos. Knockdown of sema1a during A. aegypti development results in a number of nerve cord phenotypes, including thinning, breakage, and occasional fusion of the longitudinal connectives, thin or absent commissures, and general distortion of the nerve cord. Although analysis of Drosophila melanogaster sema1a loss-of-function mutants uncovered many similar phenotypes, aspects of the longitudinal phenotypes differed between D. melanogaster and A. aegypti. The results of this investigation suggest that Sema1a is required for development of the insect ventral nerve cord, but that the developmental roles of this guidance molecule have diverged in dipteran insects.

  8. Brain Endothelial Cells Control Fertility through Ovarian-Steroid–Dependent Release of Semaphorin 3A

    Science.gov (United States)

    Messina, Andrea; Casoni, Filippo; Vanacker, Charlotte; Langlet, Fanny; Hobo, Barbara; Cagnoni, Gabriella; Gallet, Sarah; Hanchate, Naresh Kumar; Mazur, Danièle; Taniguchi, Masahiko; Mazzone, Massimiliano; Verhaagen, Joost; Ciofi, Philippe; Bouret, Sébastien G.; Tamagnone, Luca; Prevot, Vincent

    2014-01-01

    Neuropilin-1 (Nrp1) guides the development of the nervous and vascular systems, but its role in the mature brain remains to be explored. Here we report that the expression of the 65 kDa isoform of Sema3A, the ligand of Nrp1, by adult vascular endothelial cells, is regulated during the ovarian cycle and promotes axonal sprouting in hypothalamic neurons secreting gonadotropin-releasing hormone (GnRH), the neuropeptide controlling reproduction. Both the inhibition of Sema3A/Nrp1 signaling and the conditional deletion of Nrp1 in GnRH neurons counteract Sema3A-induced axonal sprouting. Furthermore, the localized intracerebral infusion of Nrp1- or Sema3A-neutralizing antibodies in vivo disrupts the ovarian cycle. Finally, the selective neutralization of endothelial-cell Sema3A signaling in adult Sema3a loxP/loxP mice by the intravenous injection of the recombinant TAT-Cre protein alters the amplitude of the preovulatory luteinizing hormone surge, likely by perturbing GnRH release into the hypothalamo-hypophyseal portal system. Our results identify a previously unknown function for 65 kDa Sema3A-Nrp1 signaling in the induction of axonal growth, and raise the possibility that endothelial cells actively participate in synaptic plasticity in specific functional domains of the adult central nervous system, thus controlling key physiological functions such as reproduction. PMID:24618750

  9. Brain endothelial cells control fertility through ovarian-steroid-dependent release of semaphorin 3A.

    Science.gov (United States)

    Giacobini, Paolo; Parkash, Jyoti; Campagne, Céline; Messina, Andrea; Casoni, Filippo; Vanacker, Charlotte; Langlet, Fanny; Hobo, Barbara; Cagnoni, Gabriella; Gallet, Sarah; Hanchate, Naresh Kumar; Mazur, Danièle; Taniguchi, Masahiko; Mazzone, Massimiliano; Verhaagen, Joost; Ciofi, Philippe; Bouret, Sébastien G; Tamagnone, Luca; Prevot, Vincent

    2014-03-01

    Neuropilin-1 (Nrp1) guides the development of the nervous and vascular systems, but its role in the mature brain remains to be explored. Here we report that the expression of the 65 kDa isoform of Sema3A, the ligand of Nrp1, by adult vascular endothelial cells, is regulated during the ovarian cycle and promotes axonal sprouting in hypothalamic neurons secreting gonadotropin-releasing hormone (GnRH), the neuropeptide controlling reproduction. Both the inhibition of Sema3A/Nrp1 signaling and the conditional deletion of Nrp1 in GnRH neurons counteract Sema3A-induced axonal sprouting. Furthermore, the localized intracerebral infusion of Nrp1- or Sema3A-neutralizing antibodies in vivo disrupts the ovarian cycle. Finally, the selective neutralization of endothelial-cell Sema3A signaling in adult Sema3aloxP/loxP mice by the intravenous injection of the recombinant TAT-Cre protein alters the amplitude of the preovulatory luteinizing hormone surge, likely by perturbing GnRH release into the hypothalamo-hypophyseal portal system. Our results identify a previously unknown function for 65 kDa Sema3A-Nrp1 signaling in the induction of axonal growth, and raise the possibility that endothelial cells actively participate in synaptic plasticity in specific functional domains of the adult central nervous system, thus controlling key physiological functions such as reproduction.

  10. Brain endothelial cells control fertility through ovarian-steroid-dependent release of semaphorin 3A.

    Directory of Open Access Journals (Sweden)

    Paolo Giacobini

    2014-03-01

    Full Text Available Neuropilin-1 (Nrp1 guides the development of the nervous and vascular systems, but its role in the mature brain remains to be explored. Here we report that the expression of the 65 kDa isoform of Sema3A, the ligand of Nrp1, by adult vascular endothelial cells, is regulated during the ovarian cycle and promotes axonal sprouting in hypothalamic neurons secreting gonadotropin-releasing hormone (GnRH, the neuropeptide controlling reproduction. Both the inhibition of Sema3A/Nrp1 signaling and the conditional deletion of Nrp1 in GnRH neurons counteract Sema3A-induced axonal sprouting. Furthermore, the localized intracerebral infusion of Nrp1- or Sema3A-neutralizing antibodies in vivo disrupts the ovarian cycle. Finally, the selective neutralization of endothelial-cell Sema3A signaling in adult Sema3aloxP/loxP mice by the intravenous injection of the recombinant TAT-Cre protein alters the amplitude of the preovulatory luteinizing hormone surge, likely by perturbing GnRH release into the hypothalamo-hypophyseal portal system. Our results identify a previously unknown function for 65 kDa Sema3A-Nrp1 signaling in the induction of axonal growth, and raise the possibility that endothelial cells actively participate in synaptic plasticity in specific functional domains of the adult central nervous system, thus controlling key physiological functions such as reproduction.

  11. Endothelial Semaphorin 7A promotes inflammation in seawater aspiration-induced acute lung injury.

    Science.gov (United States)

    Zhang, Minlong; Wang, Li; Dong, Mingqing; Li, Zhichao; Jin, Faguang

    2014-10-28

    Inflammation is involved in the pathogenesis of seawater aspiration-induced acute lung injury (ALI). Although several studies have shown that Semaphorin 7A (SEMA7A) promotes inflammation, there are limited reports regarding immunological function of SEMA7A in seawater aspiration-induced ALI. Therefore, we investigated the role of SEMA7A during seawater aspiration-induced ALI. Male Sprague-Dawley rats were underwent seawater instillation. Then, lung samples were collected at an indicated time for analysis. In addition, rat pulmonary microvascular endothelial cells (RPMVECs) were cultured and then stimulated with 25% seawater for indicated time point. After these treatments, cells samples were collected for analysis. In vivo, seawater instillation induced lung histopathologic changes, pro-inflammation cytokines release and increased expression of SEMA7A. In vitro, seawater stimulation led to pro-inflammation cytokine release, cytoskeleton remodeling and increased monolayer permeability in pulmonary microvascular endothelial cells. In addition, knockdown of hypoxia-inducible factor (HIF)-1α inhibited the seawater induced increase expression of SEMA7A. Meanwhile, knockdown of SEMA7A by specific siRNA inhibited the seawater induced aberrant inflammation, endothelial cytoskeleton remodeling and endothelial permeability. These results suggest that SEMA7A is critical in the development of lung inflammation and pulmonary edema in seawater aspiration-induced ALI, and may be a therapeutic target for this disease.

  12. Tax and Semaphorin 4D Released from Lymphocytes Infected with Human Lymphotropic Virus Type 1 and Their Effect on Neurite Growth.

    Science.gov (United States)

    Quintremil, Sebastián; Alberti, Carolina; Rivera, Matías; Medina, Fernando; Puente, Javier; Cartier, Luis; Ramírez, Eugenio; Tanaka, Yuetsu; Valenzuela, M Antonieta

    2016-01-01

    Human lymphotropic virus type 1 (HTLV-1) is a retrovirus causing HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a neurodegenerative central nervous system (CNS) axonopathy. This virus mainly infects CD4(+) T lymphocytes without evidence of neuronal infection. Viral Tax, secreted from infected lymphocytes infiltrated in the CNS, is proposed to alter intracellular pathways related to axonal cytoskeleton dynamics, producing neurological damage. Previous reports showed a higher proteolytic release of soluble Semaphorin 4D (sSEMA-4D) from CD4(+) T cells infected with HTLV-1. Soluble SEMA-4D binds to its receptor Plexin-B1, activating axonal growth collapse pathways in the CNS. In the current study, an increase was found in both SEMA-4D in CD4(+) T cells and sSEMA-4D released to the culture medium of peripheral blood mononuclear cells (PBMCs) from HAM/TSP patients compared to asymptomatic carriers and healthy donors. After a 16-h culture, infected PBMCs showed significantly higher levels of CRMP-2 phosphorylated at Ser(522). The effect was blocked either with anti-Tax or anti-SEMA-4D antibodies. The interaction of Tax and sSEMA-4D was found in secreted medium of PBMCs in patients, which might be associated with a leading role of Tax with the SEMA-4D-Plexin-B1 signaling pathway. In infected PBMCs, the migratory response after transwell assay showed that sSEMA-4D responding cells were CD4(+)Tax(+) T cells with a high CRMP-2 pSer(522) content. In the present study, the participation of Tax-sSEMA-4D in the reduction in neurite growth in PC12 cells produced by MT2 (HTLV-1-infected cell line) culture medium was observed. These results lead to the participation of plexins in the reported effects of infected lymphocytes on neuronal cells.

  13. Hüvad ärritunud pedagoogilised daamid / Vaapo Vaher

    Index Scriptorium Estoniae

    Vaher, Vaapo, 1945-

    2003-01-01

    Arvustus: XX sajandi vene kirjandus. I, Luule / [koostanud Katrin Kalamees ja Maritsa Lens. Tallinn] : Avita, 2002; XX sajandi vene kirjandus. II, Proosa / [koostanud Katrin Kalamees ja Maritsa Lens. Tallinn] : Avita, 2002. Vastuseks Vaapo Vaheri arvustusele "Vene kirjanduse õpik lõhestab kirjanikud headeks ja pahadeks", Eesti Päevaleht : Arkaadia, 25. apr. 2003: Kalamees, Katrin; Lens, Maritsa. Vastuseid Vaapo Vaheri küsimistele, Eesti Päevaleht, 2. mai, lk. 17; Vt. ka vastukajad: Tuch, Boris. Dva toma oshibok // Estonija (2002) 28. apr., lk. 9

  14. Два тома ошибок / Борис Тух

    Index Scriptorium Estoniae

    Тух, Борис, 1946-

    2003-01-01

    Arvustus: XX sajandi vene kirjandus. I, Luule / [koostanud Katrin Kalamees ja Maritsa Lens. Tallinn] : Avita, 2002; XX sajandi vene kirjandus. II, Proosa / [koostanud Katrin Kalamees ja Maritsa Lens. Tallinn] : Avita, 2002. Vastuseks Vaapo Vaheri arvustusele "Vene kirjanduse õpik lõhestab kirjanikud headeks ja pahadeks", Eesti Päevaleht : Arkaadia, 25. apr. 2003. Vt. ka vastukajad: Kalamees, Katrin; Lens, Maritsa. Vastuseid Vaapo Vaheri küsimistele, Eesti Päevaleht, 2. mai, lk. 17; Vaher, Vaapo. Hüvad ärritunud pedagoogilised daamid, Eesti Päevaleht : Arkaadia, 2. mai, lk. 17

  15. A PKC-dependent recruitment of MMP-2 controls semaphorin-3A growth-promoting effect in cortical dendrites.

    Directory of Open Access Journals (Sweden)

    Bertrand Gonthier

    Full Text Available There is increasing evidence for a crucial role of proteases and metalloproteinases during axon growth and guidance. In this context, we recently described a functional link between the chemoattractive Sema3C and Matrix metalloproteinase 3 (MMP3. Here, we provide data demonstrating the involvement of MMP-2 to trigger the growth-promoting effect of Sema3A in cortical dendrites. The in situ analysis of MMP-2 expression and activity is consistent with a functional growth assay demonstrating in vitro that the pharmacological inhibition of MMP-2 reduces the growth of cortical dendrites in response to Sema3A. Hence, our results suggest that the selective recruitment and activation of MMP-2 in response to Sema3A requires a PKC alpha dependent mechanism. Altogether, we provide a second set of data supporting MMPs as effectors of the growth-promoting effects of semaphorins, and we identify the potential signalling pathway involved.

  16. Insights into function of PSI domains from structure of the Met receptor PSI domain

    International Nuclear Information System (INIS)

    Kozlov, Guennadi; Perreault, Audrey; Schrag, Joseph D.; Park, Morag; Cygler, Miroslaw; Gehring, Kalle; Ekiel, Irena

    2004-01-01

    PSI domains are cysteine-rich modules found in extracellular fragments of hundreds of signaling proteins, including plexins, semaphorins, integrins, and attractins. Here, we report the solution structure of the PSI domain from the human Met receptor, a receptor tyrosine kinase critical for proliferation, motility, and differentiation. The structure represents a cysteine knot with short regions of secondary structure including a three-stranded antiparallel β-sheet and two α-helices. All eight cysteines are involved in disulfide bonds with the pattern consistent with that for the PSI domain from Sema4D. Comparison with the Sema4D structure identifies a structurally conserved core comprising the N-terminal half of the PSI domain. Interestingly, this part links adjacent SEMA and immunoglobulin domains in the Sema4D structure, suggesting that the PSI domain serves as a wedge between propeller and immunoglobulin domains and is responsible for the correct positioning of the ligand-binding site of the receptor

  17. Semaphorin 4A enhances lung fibrosis through activation of Akt via ...

    Indian Academy of Sciences (India)

    2015-11-28

    Nov 28, 2015 ... In the present study, we show that treatment of Sema4A on normal lung fibroblasts ... of patients with the fibrotic disease Systemic Sclerosis (SSc) showed ... modulated at multiple levels: transcription, translation, and post-.

  18. African Journal of Biotechnology - Vol 8, No 8 (2009)

    African Journals Online (AJOL)

    Thyroidal angiogenesis in zebrafish (Danio rerio) exposed to high perchlorate concentration · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. IÜ Sema, Ö Karayazi, A Isisag ...

  19. The Use and Efficacy of Mucolytic Agents

    African Journals Online (AJOL)

    1971-08-28

    Aug 28, 1971 ... Specimens of purulent and mucoid sputum from patients with chronic chest ..... preparation contains ethylene diamine tetracetic acid. (EDTA) to prevent .... is an experimental means for producing anatomic emphy- sema in ...

  20. 78 FR 31394 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Science.gov (United States)

    2013-05-24

    ... Agency (EASA), which is the Technical Agent for the Member States of the European Union, issued EASA AD... short circuit on the yaw Smart Electro-Mechanical Actuator (SEMA) ``ACTIV'' input to ground led to the...

  1. CMMI High Maturity Measurement and Analysis Workshop Report: March 2008

    National Research Council Canada - National Science Library

    Stoddard, II, Robert W; Goldenson, Dennis R; Zubrow, Dave; Harper, Erin

    2008-01-01

    .... In response to the need for clarification and guidance on implementing measurement and analysis in the context of high maturity processes, members of the SEI s Software Engineering Measurement and Analysis (SEMA...

  2. Semaphorin 3A controls allergic and inflammatory responses in experimental allergic conjunctivitis

    Directory of Open Access Journals (Sweden)

    Junmi Tanaka

    2015-02-01

    Full Text Available AIM: To assess the efficacy of topical Semaphorin-3A (SEMA3A in the treatment of allergic conjunctivitis. METHODS: Experimental allergic conjunctivitis (EAC mice model induced by short ragweed pollen (SRW in 4-week-old of BALB/c mice, mice were evaluated using haematoxylin and eosin (H&E staining, immunofluorescence and light microscope photographs. Early phase took the samples in 24h after instillation and late phase took the samples between 4 to 14d after the start of treatment. The study use of topical SEMA3A (10 U, 100 U, 1000 U eye drops and subconjunctival injection of SEMA3A with same concentration. For comparison, five types of allergy eyedrops were quantified using clinical characteristics. RESULTS: Clinical score of composite ocular symptoms of the mice treated with SEMA3A were significantly decreased both in the immediate phase and the late phase compared to those treated with commercial ophthalmic formulations and non-treatment mice. SEMA3A treatment attenuates infiltration of eosinophils entering into conjunctiva in EAC mice. The score of eosinophil infiltration in the conjunctiva of SEMA3A 1000 U-treated group were significantly lower than low-concentration of SEMA3A treated groups and non-treated group. SEMA3A treatment also suppressed T-cell proliferation in vitro and decreased serum total IgE levels in EAC mice. Moreover, Treatment of SEMA3A suppressed Th2-related cytokines (IL-5, IL-13 and IL-4 and pro-inflammatory cytokines (IFN-γ, IL-17 and TNF-α release, but increased regulatory cytokine IL-10 concentration in the conjunctiva of EAC mice. CONCLUSIONS: SEMA3A as a biological agent, showed the beneficial activity in ocular allergic processes with the less damage to the intraocular tissue. It is expected that SEMA3A may be contributed in patients with a more severe spectrum of refractory ocular allergic diseases including allergic conjunctivitis in the near future.

  3. 14. VII avati Rael Arteli galerii fotoruumis...

    Index Scriptorium Estoniae

    2004-01-01

    Anu Allase kureeritud näitus "Juhitud reisid/Guided Tours". Näitusel osalevad Liisi Peets, Katrin Tees, Piret Räni, Anu Vahtra, Daisy Lappard, Tiit Sokk (Ulvi Tiit & Marili Sokk), Raivo Hool ja Rataplan

  4. Baltic notes : the best in music

    Index Scriptorium Estoniae

    2005-01-01

    Heliplaatidest: "World Lullabies", Mielavs un Parcelaji "Paruna ar sevi", InCulto "Post Sov Pop", Lauri Saatpalu & Katrin Mandel "Sa Oled Hea", D.J.Critikal "Chapter One Ehk Teine Maitse", Jurga "Aukso Pieva", Terminaator "Go Live"

  5. Briti hotell Dunkri tänavas / Piret Tali

    Index Scriptorium Estoniae

    Tali, Piret, 1972-

    2005-01-01

    Liisi Murula ja Raili Nõlvaku kujundatud hotell Merchants House, restoran KN Cayenne, baar Ice Bar ja kohvik Cafe Time Tallinnas. Kasutatud ka tekstiilikunstnik Ülle Raadiku ja klaasikunstnik Rait Partsi töid. Valgustite autor ehtekunstnik Katrin Sipelgas

  6. HP fotovõistluse finalistid veebis / Henrik Roonemaa

    Index Scriptorium Estoniae

    Roonemaa, Henrik

    2002-01-01

    Hewlett-Packardi koduleheküljel on üleval rahvusvahelise digitaalfotograafia konkursi HP Invision Digital Photography Awards 2002 finalistide tööd, nende hulgas Katrin Arraku foto "Minu kala Vallo"

  7. Hillitsetud feministid / Teet Veispak

    Index Scriptorium Estoniae

    Veispak, Teet, 1955-

    2000-01-01

    Ajakirja "Ariadne Lõng" esinumbrist, mis esindab liberaalse feminismi vaateid. Katrin Kivimaa artiklist "Teise tootmine - Ida-Euroopa ja feminism". Esile on tõstetud kunstiteadlaste Reet Varblase ja Eda Sepa artiklid.

  8. "Ruudi" võitis Tokio festivali peaauhinna

    Index Scriptorium Estoniae

    2006-01-01

    Lastefilm "Ruudi" sai Tokyo 14. lastefilmide festivalil Kodomotachino parima mängufilmi auhinna. Filmi režissöör Katrin Laur ja nimiosas esinenud 8-aastane Paul Oskar Soe olid ka festivalikülalised

  9. Feministid põõsas / Olev Remsu

    Index Scriptorium Estoniae

    Remsu, Olev, 1947-

    1996-01-01

    Feminismist seoses ameerika filmiga 'Striptiis' ("Striptease", re̓issöör Andrew Bergman, USA 1996). Vastukaja: Kivimaa, Katrin. Feminist tuleb põõsast välja // Eesti Päevaleht. - 1996. - 4. dets. - Lk. 7

  10. Sisustusgiidi uudised / Mari Masso

    Index Scriptorium Estoniae

    Masso, Mari

    2007-01-01

    Standardi uuest kapiseeriast (disainer Katrin Soans) ja koostööst Jaapani toolitootja Okamuraga; helisummutavatest seinapaneelidest; Verner Pantoni toolist lastele; Alberto Meda pöörlevast töötoolist

  11. Põrandate pillerkaar / Ingrid Sembach-Hõbemägi

    Index Scriptorium Estoniae

    Sembach-Hõbemägi, Ingrid

    2008-01-01

    Soovitusi põrandakatete valikuks. Materjalide (puit, kork, linoleum, laminaat, plaadid, kivid, vaipkate) plussid ja miinused. Kommenteerivad Katrin Kuningas-Leius salongist Ruutmeeter, Küllike Uus Interno Plaadimajast, Anu Jaanson Vivarecist, Siret Antsmäe Floorinist

  12. Karzai pääses raketirünnakust eluga / Hendrik Vosman

    Index Scriptorium Estoniae

    Vosman, Hendrik

    2008-01-01

    Afganistani pealinnas Kabulis toimunud sõjaväeparaadile Talibani korraldatud raketirünnakus hukkus kolm inimest, president Hamid Karzai pääses vigastusteta. Kabulis viibinud Euroopa Parlamendi saadiku Katrin Saksa arvamus

  13. Genre and Everyday Conversation

    DEFF Research Database (Denmark)

    Gregersen, Frans

    2015-01-01

    The paper outlines the analysis of speech genres synchronically and diachronically and exemplifies how speech genres are emulated and transformed in an analysis of a piece of literary fiction by the Danish author Katrine Marie Guldager...

  14. Semester piiri taga, ookeanil loksuvas laevaauditooriumis / Agne Narusk

    Index Scriptorium Estoniae

    Narusk, Agne

    2008-01-01

    Ülikoolist laevas, The Scholar Ship programmist, mis viib eri rahvusest üliõpilased neljaks kuuks ümbermaailma-õppereisile. Oma kogemusi laevas õppimisest jagavad Katrin Kaun, Natalja Tamm ja Hanna-Liina Linnasmäe

  15. Kunstiteaduslik doktoritöö EKA-s kaitstud / Ingrid Ruudi

    Index Scriptorium Estoniae

    Ruudi, Ingrid

    2005-01-01

    Heie Treier "Kohalik modernsus kunstis. Eesti varamodernistliku kunsti teoreetiline ja ajalooline kontseptualiseerimine ning Karl Pärsimägi paradigmaleidmise perioodil". Juhendaja Thomas McEvilley, eelretsensent Katrin Kivimaa ja Ene Lamp. Oponent Jaak Kangilaski

  16. Fragmente taevase laega labürindist / Jan Kaus

    Index Scriptorium Estoniae

    Kaus, Jan, 1971-

    2007-01-01

    Arvustus: Benjamin, Walter. Ühesuunaline tänav : [väikesed proosalood] / saksa keelest tõlkinud [ja järelsõna:] Katrin Kaugver. Tallinn : Kultuurileht, 2007. (Loomingu Raamatukogu ; 2007, 25-26)

  17. Miks peab lõhkuma hägustunud piire? / Reelika Reinomägi

    Index Scriptorium Estoniae

    Reinomägi, Reelika

    2007-01-01

    Kaasaegse tantsulavastuse ja teatri ühisosast, seoses festivaliga "Uus tants". Tantsuetendustest: Katrin Essensoni "Manusega mõtted", Mart Kangro "Start. Based on a True Story", Kaja Kannu "There are Laika Dogs Living in Estonia"

  18. Tartu vaimukas tants / Kertu Käämbre

    Index Scriptorium Estoniae

    Käämbre, Kertu

    2007-01-01

    "Uue tantsu" festivalist Tartus. Tantsuetendustest: Katrin Essensoni "Manusega mõtted", Renate Valme "Mesta", Mart Kangro "Start. Based on a True Story", Kaja Kannu "There are Laika Dogs Living in Estonia"

  19. Iga tund võib olla riigikaitsetund / Victoria Parmas

    Index Scriptorium Estoniae

    Parmas, Victoria

    2015-01-01

    Riigikaitseõpetuse seostamisest teiste õppeainetega. Rocca al Mare koolis teevad riigikaitseõpetuse osas koostööd geograafiaõpetaja Marek Nisuma ning ajalooõpetajad Katrin Martsik ja Ronald Juurmaa

  20. Under ja tema (kirja)-mehed / Mati Soomre

    Index Scriptorium Estoniae

    Soomre, Mati, 1944-2015

    2006-01-01

    20. nov. Kumu auditooriumis esietendunud Ühenduse R.A.A.A.M teatriprojekt "Under" poetess Marie Underist. Lavastajad Merle Karusoo ja Raimo Pass, kunstnik Jaagup Roomet, helilooja Urmas Lattikas, peaosas Katrin Saukas

  1. Unetuma ülemlaul / Arne Merilai

    Index Scriptorium Estoniae

    Merilai, Arne, 1961-

    2011-01-01

    20. nov. 2006 Kumu auditooriumis esietendunud Ühenduse R.A.A.A.M teatriprojekt "Under" poetess Marie Underist. Lavastajad Merle Karusoo ja Raimo Pass, kunstnik Jaagup Roomet, helilooja Urmas Lattikas, peaosas Katrin Saukas

  2. Mitte ainult spordihoone = More than a Gym / Tuuli Köller

    Index Scriptorium Estoniae

    Köller, Tuuli

    2009-01-01

    Tartus 2009. a. valminud Eesti Maaülikooli spordihoonest, mille arhitektid on Maarja Kask, Karli Luik ja Ralf Lõoke, projekteerija AB Salto, sisekujundajad Katrin Kaevats ja Jaan Frank Port. Projekt 2007

  3. Ökokontor on õhu- ja loomingurikas / Nelli Pello

    Index Scriptorium Estoniae

    Pello, Nelli

    2007-01-01

    Tööruumide säästvast renoveerimisest looduslike materjalidega. Tartu trükikojast Triip, reklaamiagentuuri Dreamers kontorist, Säästva Arengu Klubi büroost. Kommenteerivad Eva Peedimaa, Katrin Kull

  4. Kaadris: "Naerata ometi" / Ulve Määrits

    Index Scriptorium Estoniae

    Määrits, Ulve

    2012-01-01

    Restaureeriti mängufilm "Naerata ometi". Sel puhul toimus ringreis Tilsis ning taastatud filmi esitlus Põlva kultuurikeskuses, kus osalesid ning meenutasid filmi valmimist ka lavastaja Arvo Iho ning osatäitjad Katrin Tamleht ja Kerttu Aaving

  5. "Ruudi" - helge muinasjutt lastele, iroonia vanematele / Teelemari Loonet

    Index Scriptorium Estoniae

    Loonet, Teelemari, 1987-

    2006-01-01

    Lastefilm "Ruudi" : stsenaristid Aare Toikka, Aarne Mägi : režissöör Katrin Laur : nimiosas lapsnäitleja Paul Oskar Soe : operaator Rein Kotov : Allfilm - MRP Matila Röhr Productions - Schmidtz Katze Filmkollektiv 2006

  6. Eesti Maaülikooli spordihoone = The Sports Hall of the Estonian University of Life Sciences / Margit Mutso

    Index Scriptorium Estoniae

    Mutso, Margit, 1966-

    2010-01-01

    Tartus Kreutzwaldi 3 asuva EMÜ spordihoone arhitektuursest lahendusest. Arhitektid: Maarja Kask, Karli Luik, Ralf Lõoke (Salto AB). Sisearhitektid: Katrin Kaevats, Jaan Port (Funk AB). Žürii liikme Kalle Komissarovi hinnang kultuurkapitali aastapreemiale esitatud hoonele

  7. Kes vajab pooltõdedele rajatud patriotismi / Valle-Sten Maiste

    Index Scriptorium Estoniae

    Maiste, Valle-Sten, 1972-

    2007-01-01

    Kuressaare Linnateatri ja ühenduse R.A.A.A.M koostöös valminud dokumentaalmaterjalidel põhinevast lavastusest Betti Alverist ja Heiti Talvikust "Võlg". Loo autor on Katrin Saukas, lavastaja Merle Karusoo

  8. Kirev moepilt / Britt Rosen

    Index Scriptorium Estoniae

    Rosen, Britt, 1968-

    2007-01-01

    FIBITi moepäevadest Tallinnas Viru keskuses, stilistid Gerli Tinn, Liisi Eesmaa, Kirill Safonov. Kuldnõela auhinna pälvis Katrin Kuldma kollektsiooni Chocolat eest. Oma loomingut esitlesid Reet Aus, Tiiu Roosma, Marika Siska

  9. Marek Kiisa 9 ametit / Marek Kiisa ; interv. Jaana Liigand

    Index Scriptorium Estoniae

    Kiisa, Marek

    2006-01-01

    Kataloogifirma Miss Mary of Sweden juhatuse esimees oma karjäärist, juhtimiskogemustest ning Eesti ja Rootsi organisatsioonimudelitest. Vt. samas: Marek Kiisa; Katrin Verniku lühiintervjuud Marek Kiisaga

  10. Uhiuus spordimaja annab mitmele klubile kodusaali / Mari-Liis Hüvato

    Index Scriptorium Estoniae

    Hüvato, Mari-Liis

    2006-01-01

    Avati Tartu Spordimaja A. Le Coq Sport. Projekteerija Muru & Pere arhitektuuribüroo, sisearhitekt Katrin Kaevats. Kommenteerivad Jaan Veeranna, Janika Mölder, Andres Põhjala, Urmas Tali, Aivo Erkmaa

  11. Kliiniline kapitalism ja naise neim / Vaapo Vaher

    Index Scriptorium Estoniae

    Vaher, Vaapo, 1945-

    2011-01-01

    Tutvustus: Kõiv, Salme. Reet Tammiku. Tallinn : Eesti Raamat, 2011 ; Kalda, Katrin. Eesti romaan / tõlkinud Anti Saar. Tallinn : Varrak, 2011 ; Zola, Émile. Saak / tõlkinud Kaja Riesen. Tallinn : Eesti Raamat, 2011

  12. Venezia filmifestivali punane vaip ootab tänavu ka eestlasi / Tiit Tuumalu

    Index Scriptorium Estoniae

    Tuumalu, Tiit, 1971-

    2007-01-01

    Eesti mängufilm "Sügisball" (režissöör Veiko Õunpuu, produtsent Katrin Kissa) esilinastub 7. septembril Venezia 64. filmifestivali konkursiprogrammis Orizzonti. Ka teistest võistlevatest filmidest

  13. Popmuusika / Valner Valme

    Index Scriptorium Estoniae

    Valme, Valner, 1970-

    2007-01-01

    Uutest heliplaatidest The Charlatans "Forever", Young Jeezy "The Inspiration", Girls Aloud "The Sound Of Girls Aloud", Six Organs Of Admittance "The Sun Awakens", Take That "Beautiful World", Lauri Saatpalu & Katrin Mandel "Ei kunagi", "Republicafrobeat"

  14. Eesti mood esitles end Stockholmis / Peep Sooman

    Index Scriptorium Estoniae

    Sooman, Peep, 1978-

    1999-01-01

    Eesti moepäevadel Stockholmis esitleti moeshow'l üle 80 rõivakollektsiooni, osalesid: Baltika, Klementi, Sangar, Zik-Zak (Ivo Nikkolo), Katrin Kuldma Moemaja, Arne Studio, Hipo, Uljas & Tütred, Virulane, Althea.

  15. Teavikute ost riigihankega / Meeli Veskus

    Index Scriptorium Estoniae

    Veskus, Meeli, 1953-

    2007-01-01

    1. maist 2007 hakkas kehtima uus riigihangete seadus, mida raamatukogudes tuleb järgida teavikuid komplekteerides. Lisa: "Raamatukogu" küsib: kuidas riigihangete seadust rakendatakse? Vastavad Tallinna Keskraamatukogu direktor Kaie Holm ja Rapla Keskraamatukogu pearaamatukoguhoidja Katrin Niklus

  16. Under Under Under / Merit Kask

    Index Scriptorium Estoniae

    Kask, Merit

    2006-01-01

    20. nov. esietendub Kumu auditooriumis MTÜ Ühenduse R.A.A.A.M teatriprojekt "Under" poetess Marie Underist. Lavastajad Merle Karusoo ja Raimo Pass, kunstnik Jaagup Roomet, helilooja Urmas Lattikas, peaosas Katrin Saukas

  17. Underist, Underiga, Underini Underina, Underiks Underita / Katre Väli

    Index Scriptorium Estoniae

    Väli, Katre

    2006-01-01

    20. nov. Kumu auditooriumis esietendunud Ühenduse R.A.A.A.M teatriprojekt "Under" poetess Marie Underist. Lavastajad Merle Karusoo ja Raimo Pass, kunstnik Jaagup Roomet, helilooja Urmas Lattikas, peaosas Katrin Saukas

  18. Tasku kaubandus- ja vabaajakeskuse üldruumid ja konverentsikeskus = Tasku shopping and recreational centre common areas and conference centre / Margit Mutso

    Index Scriptorium Estoniae

    Mutso, Margit, 1966-

    2009-01-01

    Tartus Turu 2 asuvas Tasku keskuses asuvad ruumid kujundasid Argo Vaikla ja Katrin Vaikla (Vaikla Disain). Hoone arhitektid on Madis Renter ja Kristiina Renter (AB Kalle Rõõmus). Žürii hinnang kultuurkapitali aastapreemiale esitatud sisekujundusele

  19. Tallinna Ülikooli kirjastus tegi uue raamatusarja

    Index Scriptorium Estoniae

    2013-01-01

    Tallinna Ülikooli kirjastus hakkas välja andma uut raamatusarja "Acta Universitatis Tallinnensis. Artes", mille avaraamatuks on Katrin Kivimaa koostatud artiklikogumik "Working with Feminism: Curating and Exhibitions in Eastern Europe"

  20. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2009-02-13

    Feb 13, 2009 ... Author Affiliations. Katrin Schaefer1 Fred L Bookstein1 2. Department of Anthropology, University of Vienna, Vienna, Austria; Department of Statistics, University of Washington, Seattle, USA ...

  1. Coaching näitab töötajast hoolimist / Urve Vilk

    Index Scriptorium Estoniae

    Vilk, Urve

    2012-01-01

    Konverentsil "Arengukompass 2012: uue ajastu organisatsiooni arendusvahendid" esinenud juhtimiskoolitaja ja sertifitseeritud coach'i Ivar Lukki, Elioni tehnoloogiadirektori Kalev Reiljani ja superviisori Katrin Aava Tallinna Ülikoolist sõnavõttudest

  2. PÖFF-i festivalid pakuvad aina paremat programmi / Margit Rebane

    Index Scriptorium Estoniae

    Rebane, Margit

    2004-01-01

    VIII Pimedate Ööde filmifestivali alafestivalid : tudengifilmifestival Sleepwalkers, laste- ja noortefilmide festival Just Film, animafilmifestival Animated Dreams (korraldajad Katrin Rajasaare, Elen Lotman, Heilika Võsu). Lisa : Kus toimub? Palju maksab?

  3. Hotelli Palace**** renoveerimine = Renovation of the hotel Palace**** / Argo Vaikla

    Index Scriptorium Estoniae

    Vaikla, Argo, 1966-

    2015-01-01

    Hotell Palace Tallinnas Vabaduse väljak 3, valminud 2014. Hoone rekonstrueerimisprojekt Reet Valk (AB Reet Valk), sisearhitektid Katrin Vaikla, Argo Vaikla, Mari-Liis Süld, Riin Luuk. 2014. aasta Kultuurkapitali Arhitektuuripreemia kandidaat

  4. Plaadid / Priit Hõbemägi

    Index Scriptorium Estoniae

    Hõbemägi, Priit, 1957-

    2005-01-01

    Uutest heliplaatidest Neil Young "Prairie Wind", Sigur Ros "Takk...", Paul McCartney "Chaos and Creation in the Backyard", Lauri Saatpalu, Katrin Mandel "Sa oled hea", "Rock2005", The Corrs "Home", Dandy Warhols "Odditorium or Warlords of Mars"

  5. Pärnu Kontserdimaja arhitektuurikonkurss = Architectural Competition of Pärnu Concert Hall / Martti Preem

    Index Scriptorium Estoniae

    Preem, Martti, 1949-

    2001-01-01

    Asukohavalikust, premeeritud ja äramärgitud töödest. Konkursi tulemused: I preemia - Hanno Grossschmidt, Katrin Koov, Kaire Nõmm, Üla Koppel; II - Indrek Erm, Emil Urbel; III - Kalle Komissarov, Andres Ojari. 21 ill.

  6. International conference "Cultural Plurality in Estonia : Policies and Solutions"

    Index Scriptorium Estoniae

    2000-01-01

    Ettekandjad: Katrin Saks, Mall Hellam, Mati Luik, Kirsti Häkkinen, Vello Pettai, Ivi Proos, Katri Raik, NiinaOrhimenko, Ib Ostergaard Rasmussen, Urve Läänemets, Jüri Valge, Aleksander Dusman, Raivo Juurak, Rein Ruutsoo

  7. NU Performance'il läheb kunst bändiks kätte ära / Janar Ala

    Index Scriptorium Estoniae

    Ala, Janar, 1979-

    2009-01-01

    III Nu Performance festival "Recycle Pop" Tallinnas Kanuti Gildi saalis 11.11.-14.11.2009, kuraator Anders Härm. Osalevad teatrigrupp Baktruppen Norrast, Carole Douillard Prantsusmaalt, Lotte Jürjendal ja Katrin Ratte Eestist

  8. Must maja, valge aed / Mihkel Karu

    Index Scriptorium Estoniae

    Karu, Mihkel, 1983-

    2012-01-01

    Laagris 2010. aastal valminud eramust. Tänavapoolne aed on valatud betoonist. Arhitektid: Peeter Pere, Urmas Muru, Anna-Maria Erik (AB Muru & Pere). Sisearhitektid: Katrin Kaevats, Peeter Pere, Urmas Muru. Projekt. 2008. Peeter Pere kommentaar

  9. Festivalipäevik III / Margaret Tali, Anu Allas, Margit Tõnson...[jt.

    Index Scriptorium Estoniae

    2005-01-01

    Rahvusvaheline NU Performance festival "Continental Breakfast" Tallinnas Kanuti Gildi saalis 2.-24. nov. 2005. Hollandlase Kim H. Veltmani loengu formaadis performance "World tree". Katrin Essensoni performance "Designed to make difference". Gob Squad (Saksamaa/Inglismaa) "Super Night Shot".

  10. Saukas ja Karusoo tõid Marie Underi elu teatrilavale / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2006-01-01

    20. nov. Kumu auditooriumis esietendunud Ühenduse R.A.A.A.M teatriprojekt "Under" poetess Marie Underist. Lavastajad Merle Karusoo ja Raimo Pass, kunstnik Jaagup Roomet, helilooja Urmas Lattikas, peaosas Katrin Saukas

  11. Sõlmes alumiiniummaja = Aluminium House in a Knot

    Index Scriptorium Estoniae

    2008-01-01

    Alumiiniumplaatidega kaetud sõlmekujulise plaaniga eramu (256 m2). Arhitektid: Peeter Pere, Urmas Muru. Projektbüroo: Muru & Pere. Konsultant Katrin Kaevats. Valmis: 2007. 2 plaani, 4 värv. välisvaadet, sisevaade

  12. Eduard Odinets : "Olen eestlane, kelle emakeel on vene keel" / Eduard Odinets ; interv. Erik Kalda

    Index Scriptorium Estoniae

    Odinets, Eduard, 1976-

    2006-01-01

    Ilmunud ka: Severnoje Poberezhje Ilmunud ka: Severnoje Poberezhje : Subbota 3. juuni lk. 3. Riigikogu sotsiaaldemokraatide fraktsiooni nõunik oma poliitikukarjäärist. Arvamust avaldab Katrin Saks ja Meelis Goldberg (Severnoje Pob.)

  13. Plaadid / Kaarel Kressa

    Index Scriptorium Estoniae

    Kressa, Kaarel, 1983-

    2007-01-01

    Uutest heliplaatidest Kasabian "Empire", Katrin Mandel ja Lauri Saatpalu "Ei kunagi", The Hold Steady "Boys & Girls in America", "Corinne Bailey Rae", FAll Out Boy "Infinity On High", Laleh "Prinsessor", Melody Club "Scream"

  14. Rahvuslikus stiilis lastetuba meeldis nii asjatundjatele kui ka publikule / Siret Mägi

    Index Scriptorium Estoniae

    Mägi, Siret

    2007-01-01

    Tallinna Mustika ostukeskuses kuulutati välja sisekujunduskonkursi "Rahvuslik tuba" võitjad. Parimaks tunnistati Eva Herrera, II koha pälvis Gudrun Vung ning III koha Helen Sarapuu ja Katrin Rooger

  15. "Ja govorju : iskusstvo!" / Anastasia Semjonova

    Index Scriptorium Estoniae

    Semjonova, Anastasia

    2006-01-01

    Tartu kunstikuu 2006 avamisest ja üritustest. Peakorraldajaks on Tartu Kõrgem Kunstikool, üldjuht Katrin Ruus. Kunstikuu staabiks on Tartu vana kaubamaja. Raeplatsil avati Kirke Kangro valmistatud jääskulptuur

  16. V zashtshitu zdanija narvskoi Birzhi / Jüri Kuuskemaa

    Index Scriptorium Estoniae

    Kuuskemaa, Jüri, 1942-

    2006-01-01

    Eesti Muinsuskaitse Seltsi juhatuse avaldus seoses Tartu Ülikooli Narva kolledzhi projektiga. Sisaldab retsensiooni projektile "Vihm" (autorid Katrin Koov, Indrek Peil, Siiri Vallner), mis on inspireeritud inglise skulptori Rachel Whitereadi loomingust

  17. Tallinnasse Rävala pst. 19 kavandatava Tallinna Muusikakeskkooli, Tallinna Balletikooli ning G. Otsa nimelise muusikakooli ühise õppehoone arhitektuurikonkurss = Architectural Competition for the Joint School Building of Tallinn Music-Specialised

    Index Scriptorium Estoniae

    Puusepp, Raivo

    2003-01-01

    I preemia - Andres Siim, Krister Ausing, II - Marika Lõoke, III - Maia Tüür, Andres Sevtshuk, Gabriel Evangelisti, ostupreemiad: Armin Valter, Vilen Künnapu ning Siiri Vallner, Katrin Koov, Veronika Valk

  18. Semaphorin4D Drives CD8+ T-Cell Lesional Trafficking in Oral Lichen Planus via CXCL9/CXCL10 Upregulations in Oral Keratinocytes.

    Science.gov (United States)

    Ke, Yao; Dang, Erle; Shen, Shengxian; Zhang, Tongmei; Qiao, Hongjiang; Chang, Yuqian; Liu, Qing; Wang, Gang

    2017-11-01

    Chemokine-mediated CD8 + T-cell recruitment is an essential but not well-established event for the persistence of oral lichen planus (OLP). Semaphorin 4D (Sema4D)/CD100 is implicated in immune dysfunction, chemokine modulation, and cell migration, which are critical aspects for OLP progression, but its implication in OLP pathogenesis has not been determined. In this study, we sought to explicate the effect of Sema4D on human oral keratinocytes and its capacity to drive CD8 + T-cell lesional trafficking via chemokine modulation. We found that upregulations of sSema4D in OLP tissues and blood were positively correlated with disease severity and activity. In vitro observation revealed that Sema4D induced C-X-C motif chemokine ligand 9/C-X-C motif chemokine ligand 10 production by binding to plexin-B1 via protein kinase B-NF-κB cascade in human oral keratinocytes, which elicited OLP CD8 + T-cell migration. We also confirmed using clinical samples that elevated C-X-C motif chemokine ligand 9/C-X-C motif chemokine ligand 10 levels were positively correlated with sSema4D levels in OLP lesions and serum. Notably, we determined matrix metalloproteinase-9 as a new proteolytic enzyme for the cleavage of sSema4D from the T-cell surface, which may contribute to the high levels of sSema4D in OLP lesions and serum. Our findings conclusively revealed an amplification feedback loop involving T cells, chemokines, and Sema4D-dependent signal that promotes OLP progression. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  19. Semaphorin 4C Protects against Allergic Inflammation: Requirement of Regulatory CD138+ Plasma Cells.

    Science.gov (United States)

    Xue, Di; Kaufman, Gabriel N; Dembele, Marieme; Beland, Marianne; Massoud, Amir H; Mindt, Barbara C; Fiter, Ryan; Fixman, Elizabeth D; Martin, James G; Friedel, Roland H; Divangahi, Maziar; Fritz, Jörg H; Mazer, Bruce D

    2017-01-01

    The regulatory properties of B cells have been studied in autoimmune diseases; however, their role in allergic diseases is poorly understood. We demonstrate that Semaphorin 4C (Sema4C), an axonal guidance molecule, plays a crucial role in B cell regulatory function. Mice deficient in Sema4C exhibited increased airway inflammation after allergen exposure, with massive eosinophilic lung infiltrates and increased Th2 cytokines. This phenotype was reproduced by mixed bone marrow chimeric mice with Sema4C deficient only in B cells, indicating that B lymphocytes were the key cells affected by the absence of Sema4C expression in allergic inflammation. We determined that Sema4C-deficient CD19 + CD138 + cells exhibited decreased IL-10 and increased IL-4 expression in vivo and in vitro. Adoptive transfer of Sema4c -/- CD19 + CD138 + cells induced marked pulmonary inflammation, eosinophilia, and increased bronchoalveolar lavage fluid IL-4 and IL-5, whereas adoptive transfer of wild-type CD19 + CD138 + IL-10 + cells dramatically decreased allergic airway inflammation in wild-type and Sema4c -/- mice. This study identifies a novel pathway by which Th2-mediated immune responses are regulated. It highlights the importance of plasma cells as regulatory cells in allergic inflammation and suggests that CD138 + B cells contribute to cytokine balance and are important for maintenance of immune homeostasis in allergic airways disease. Furthermore, we demonstrate that Sema4C is critical for optimal regulatory cytokine production in CD138 + B cells. Copyright © 2016 by The American Association of Immunologists, Inc.

  20. Elu koos loodusega / Ell-Maaja Randküla

    Index Scriptorium Estoniae

    Randküla, Ell-Maaja, 1939-2016

    2005-01-01

    Villa Harjumaal Viimsi vallas Miidurannas. Arhitekt Emil Urbel. Sisekujundus: Katrin Vaikla, Argo Vaikla, Tiina Teng, AS Vaikla Disain. Villa pälvis Eesti Sisearhitektide Liidu 2004. a. aastapreemia. Argo ja Katrin Vaiklast, AS Vaikla Disain tähtsamad tööd. Tiina Tengist, tema erialasest tegevusest. Liis Lindverest, tema tähtsamad tööd. Ill.: 3 plaani, 11 värv. vaadet

  1. Unicorn

    OpenAIRE

    K. Jivkova

    2012-01-01

    This article contains five short poems. The author, Katrin Jivkova (10), is Bulgarian but lives in the UK. She will be in year 6 in September. From a very early age Katrin has been dreaming of becoming a writer. She has already written many short stories and these are her first attempts at writing poetry. The poems are inspired by frightening stories that are popular among children of her age and keep them awake at nights.

  2. Unicorn

    Directory of Open Access Journals (Sweden)

    K. Jivkova

    2012-09-01

    Full Text Available This article contains five short poems. The author, Katrin Jivkova (10, is Bulgarian but lives in the UK. She will be in year 6 in September. From a very early age Katrin has been dreaming of becoming a writer. She has already written many short stories and these are her first attempts at writing poetry. The poems are inspired by frightening stories that are popular among children of her age and keep them awake at nights.

  3. Pädaste mõis pakub nii uut kui vana! / Aale Kask

    Index Scriptorium Estoniae

    Kask, Aale

    2008-01-01

    Renoveeritud Pädaste mõisa peahoonest (1875). Omanikud Imre Sooäär ja Martin Breuer. Mõisaansambli restaureerimine toimus aastail 1996-2008. Restaureerimisarhitekt Katrin Etverk. Sisearhitektuur: Imre Sooäär, Kärt Kukkur. Restoranisaal kasvab üle talveaiaks. Kärt Kukkuri, Katrin Etverki ja Ülle Grishakovi kommentaarid. Värv. välisvaade, 14 sisevaadet

  4. The role of semaphorin 4D as a potential biomarker for antiangiogenic therapy in colorectal cancer

    Directory of Open Access Journals (Sweden)

    Ding X

    2016-03-01

    Full Text Available Xiaojie Ding,1,2,* Lijuan Qiu,1,2,* Lijuan Zhang,3 Juemin Xi,1,2 Duo Li,1,2 Xinwei Huang,1,2 Yujiao Zhao,1,2 Xiaodang Wang,1,2 Qiangming Sun1,2 1Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, 2Molecular Epidemiology Joint Laboratory, Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases, 3Department of Pathology, The Third Affiliated Hospital of Kunming Medical University (Yunnan Provincial Tumor Hospital, Kunming, People’s Republic of China*These authors contributed equally to this workBackground: Semaphorin 4D (Sema4D belongs to the class IV semaphorins, and accumulating evidence has indicated that its elevated level may be one strategy by which tumors evade current antiangiogenic therapies. The biological roles of Sema4D in colorectal cancer (CRC, however, remain largely undefined. This study was designed to investigate the effects of Sema4D on tumor angiogenesis and growth in CRC, especially in different vascular endothelial growth factor (VEGF backgrounds.Methods: The expression of Sema4D in human CRC was evaluated by immunohistochemical analysis of tumors and their matching normal control tissues. The expression level of Sema4D and VEGF was investigated in different CRC cell lines. To evaluate the contributions of Sema4D to tumor-induced angiogenesis, two CRC cell lines with opposite VEGF backgrounds were infected with lentiviruses expressing Sema4D or Sema4D short hairpin RNA, followed by in vitro migration and in vivo tumor angiogenic assays.Results: Immunohistochemical analysis of human CRC revealed high levels of Sema4D in a cell surface pattern. In all, 84.85% of CRC samples analyzed exhibited moderate to strong Sema4D expression. The positive ratios of Sema4D staining for well, moderately, and poorly differentiated cancers were 71.43%, 96.67%, and 77.27%, respectively. Sema4D is highly expressed in five different CRC cell lines, while VEGF

  5. Semaphorin 3A Induces Odontoblastic Phenotype in Dental Pulp Stem Cells.

    Science.gov (United States)

    Yoshida, S; Wada, N; Hasegawa, D; Miyaji, H; Mitarai, H; Tomokiyo, A; Hamano, S; Maeda, H

    2016-10-01

    In cases of pulp exposure due to deep dental caries or severe traumatic injuries, existing pulp-capping materials have a limited ability to reconstruct dentin-pulp complexes and can result in pulpectomy because of their low potentials to accelerate dental pulp cell activities, such as migration, proliferation, and differentiation. Therefore, the development of more effective therapeutic agents has been anticipated for direct pulp capping. Dental pulp tissues are enriched with dental pulp stem cells (DPSCs). Here, the authors investigated the effects of semaphorin 3A (Sema3A) on various functions of human DPSCs in vitro and reparative dentin formation in vivo in a rat dental pulp exposure model. Immunofluorescence staining revealed expression of Sema3A and its receptor Nrp1 (neuropilin 1) in rat dental pulp tissue and human DPSC clones. Sema3A induced cell migration, chemotaxis, proliferation, and odontoblastic differentiation of DPSC clones. In addition, Sema3A treatment of DPSC clones increased β-catenin nuclear accumulation, upregulated expression of the FARP2 gene (FERM, RhoGEF, and pleckstrin domain protein 2), and activated Rac1 in DPSC clones. Furthermore, in the rat dental pulp exposure model, Sema3A promoted reparative dentin formation with dentin tubules and a well-aligned odontoblast-like cell layer at the dental pulp exposure site and with novel reparative dentin almost completely covering pulp tissue at 4 wk after direct pulp capping. These findings suggest that Sema3A could play an important role in dentin regeneration via canonical Wnt/β-catenin signaling. Sema3A might be an alternative agent for direct pulp capping, which requires further study. © International & American Associations for Dental Research 2016.

  6. Frequent deletion of 3p21.1 region carrying semaphorin 3G and aberrant expression of the genes participating in semaphorin signaling in the epithelioid type of malignant mesothelioma cells.

    Science.gov (United States)

    Yoshikawa, Yoshie; Sato, Ayuko; Tsujimura, Tohru; Morinaga, Tomonori; Fukuoka, Kazuya; Yamada, Shusai; Murakami, Aki; Kondo, Nobuyuki; Matsumoto, Seiji; Okumura, Yoshitomo; Tanaka, Fumihiro; Hasegawa, Seiki; Hashimoto-Tamaoki, Tomoko; Nakano, Takashi

    2011-12-01

    Array-based comparative genomic hybridization analysis was performed on 21 malignant mesothelioma (MM) samples (16 primary cell cultures and 5 cell lines) and two reactive mesothelial hyperplasia (RM) primary cell cultures. The RM samples did not have any genomic losses or gains. In MM samples, deletions in 1p, 3p21, 4q, 9p21, 16p13 and 22q were detected frequently. We focused on 3p21 because this deletion was specific to the epithelioid type. Especially, a deletion in 3p21.1 region carrying seven genes including SEMA3G was found in 52% of MM samples (11 of 14 epithelioid samples). The allele loss of 3p21.1 might be a good marker for the epithelioid MM. A homozygous deletion in this region was detected in two MM primary cell cultures. A heterozygous deletion detected in nine samples contained the 3p21.1 region and 3p21.31 one carrying the candidate tumor suppressor genes such as semaphorin 3F (SEMA3F), SEMA3B and Ras association (RalGDS/AF-6) domain family member 1 (RASSF1A). SEMA3B, 3F and 3G are class 3 semaphorins and inhibit growth by competing with vascular endothelial growth factor (VEGF) through binding to neuropilin. All MM samples downregulated the expression of more than one gene for SEMA3B, 3F and 3G when compared with Met5a, a normal pleura-derived cell line. Moreover, in 12 of 14 epithelioid MM samples the expression level of SEMA3A was lower than that in Met5a and the two RM samples. An augmented expression of VEGFA was detected in half of the MM samples. The expression ratio of VEGFA/SEMA3A was significantly higher in the epithelioid MMs than in Met5a, RMs and the non-epithelioid MMs. Our data suggest that the downregulated expression of SEMA3A and several SEMA3s results in a loss of inhibitory activities in tumor angiogenesis and tumor growth of VEGFA; therefore, it may play an important role on the pathogenesis of the epithelioid type of MM.

  7. Mechanism of selective VEGF-A binding by neuropilin-1 reveals a basis for specific ligand inhibition.

    Directory of Open Access Journals (Sweden)

    Matthew W Parker

    Full Text Available Neuropilin (Nrp receptors function as essential cell surface receptors for the Vascular Endothelial Growth Factor (VEGF family of proangiogenic cytokines and the semaphorin 3 (Sema3 family of axon guidance molecules. There are two Nrp homologues, Nrp1 and Nrp2, which bind to both overlapping and distinct members of the VEGF and Sema3 family of molecules. Nrp1 specifically binds the VEGF-A(164/5 isoform, which is essential for developmental angiogenesis. We demonstrate that VEGF-A specific binding is governed by Nrp1 residues in the b1 coagulation factor domain surrounding the invariant Nrp C-terminal arginine binding pocket. Further, we show that Sema3F does not display the Nrp-specific binding to the b1 domain seen with VEGF-A. Engineered soluble Nrp receptor fragments that selectively sequester ligands from the active signaling complex are an attractive modality for selectively blocking the angiogenic and chemorepulsive functions of Nrp ligands. Utilizing the information on Nrp ligand binding specificity, we demonstrate Nrp constructs that specifically sequester Sema3 in the presence of VEGF-A. This establishes that unique mechanisms are used by Nrp receptors to mediate specific ligand binding and that these differences can be exploited to engineer soluble Nrp receptors with specificity for Sema3.

  8. The association between semaphorin 3A levels and gluten-free diet in patients with celiac disease.

    Science.gov (United States)

    Kessel, Aharon; Lin, Chen; Vadasz, Zahava; Peri, Regina; Eiza, Nasren; Berkowitz, Drora

    2017-11-01

    Celiac disease (CD) is an inflammatory disease affecting the small intestine. We aim to assess serum level and expression of semaphorin 3A (Sema3A) on T regulatory (Treg) cells in CD patients. Twenty-six newly diagnosed celiac patients, 13 celiac patients on a gluten-free diet and 16 healthy controls included in the study. Sema3A protein level in the serum of celiac patients was significantly higher compared to healthy group (7.17±1.8ng/ml vs. 5.67±1.5ng/ml, p=0.012). Sema3A expression on Treg cells was statistically lower in celiac patients compared to healthy subjects (p=0.009) and significantly lower in celiac patients compared to celiac patients on gluten free diet (p=0.04). Negative correlation was found between Sema3A on Teg cells and the level of IgA anti-tTG antibodies (r=-0.346, p<0.01) and anti-DGP (r=-0.448, p<0.01). This study suggests involvement of the Sema3A in the pathogenesis of CD. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Semaphorin 3 C drives epithelial-to-mesenchymal transition, invasiveness, and stem-like characteristics in prostate cells.

    Science.gov (United States)

    Tam, Kevin J; Hui, Daniel H F; Lee, Wilson W; Dong, Mingshu; Tombe, Tabitha; Jiao, Ivy Z F; Khosravi, Shahram; Takeuchi, Ario; Peacock, James W; Ivanova, Larissa; Moskalev, Igor; Gleave, Martin E; Buttyan, Ralph; Cox, Michael E; Ong, Christopher J

    2017-09-13

    Prostate cancer (PCa) is among the most commonly-occurring cancers worldwide and a leader in cancer-related deaths. Local non-invasive PCa is highly treatable but limited treatment options exist for those with locally-advanced and metastatic forms of the disease underscoring the need to identify mechanisms mediating PCa progression. The semaphorins are a large grouping of membrane-associated or secreted signalling proteins whose normal roles reside in embryogenesis and neuronal development. In this context, semaphorins help establish chemotactic gradients and direct cell movement. Various semaphorin family members have been found to be up- and down-regulated in a number of cancers. One family member, Semaphorin 3 C (SEMA3C), has been implicated in prostate, breast, ovarian, gastric, lung, and pancreatic cancer as well as glioblastoma. Given SEMA3C's roles in development and its augmented expression in PCa, we hypothesized that SEMA3C promotes epithelial-to-mesenchymal transition (EMT) and stem-like phenotypes in prostate cells. In the present study we show that ectopic expression of SEMA3C in RWPE-1 promotes the upregulation of EMT and stem markers, heightened sphere-formation, and cell plasticity. In addition, we show that SEMA3C promotes migration and invasion in vitro and cell dissemination in vivo.

  10. Semaphorin6A acts as a gate keeper between the central and the peripheral nervous system

    Directory of Open Access Journals (Sweden)

    Sadhu Rejina

    2007-12-01

    Full Text Available Abstract Background During spinal cord development, expression of chicken SEMAPHORIN6A (SEMA6A is almost exclusively found in the boundary caps at the ventral motor axon exit point and at the dorsal root entry site. The boundary cap cells are derived from a population of late migrating neural crest cells. They form a transient structure at the transition zone between the peripheral nervous system (PNS and the central nervous system (CNS. Ablation of the boundary cap resulted in emigration of motoneurons from the ventral spinal cord along the ventral roots. Based on its very restricted expression in boundary cap cells, we tested for a role of Sema6A as a gate keeper between the CNS and the PNS. Results Downregulation of Sema6A in boundary cap cells by in ovo RNA interference resulted in motoneurons streaming out of the spinal cord along the ventral roots, and in the failure of dorsal roots to form and segregate properly. PlexinAs interact with class 6 semaphorins and are expressed by both motoneurons and sensory neurons. Knockdown of PlexinA1 reproduced the phenotype seen after loss of Sema6A function both at the ventral motor exit point and at the dorsal root entry site of the lumbosacral spinal cord. Loss of either PlexinA4 or Sema6D function had an effect only at the dorsal root entry site but not at the ventral motor axon exit point. Conclusion Sema6A acts as a gate keeper between the PNS and the CNS both ventrally and dorsally. It is required for the clustering of boundary cap cells at the PNS/CNS interface and, thus, prevents motoneurons from streaming out of the ventral spinal cord. At the dorsal root entry site it organizes the segregation of dorsal roots.

  11. Effects of mechanical repetitive load on bone quality around implants in rat maxillae.

    Directory of Open Access Journals (Sweden)

    Yusuke Uto

    Full Text Available Greater understanding and acceptance of the new concept "bone quality", which was proposed by the National Institutes of Health and is based on bone cells and collagen fibers, are required. The novel protein Semaphorin3A (Sema3A is associated with osteoprotection by regulating bone cells. The aims of this study were to investigate the effects of mechanical loads on Sema3A production and bone quality based on bone cells and collagen fibers around implants in rat maxillae. Grade IV-titanium threaded implants were placed at 4 weeks post-extraction in maxillary first molars. Implants received mechanical loads (10 N, 3 Hz for 1800 cycles, 2 days/week for 5 weeks from 3 weeks post-implant placement to minimize the effects of wound healing processes by implant placement. Bone structures, bone mineral density (BMD, Sema3A production and bone quality based on bone cells and collagen fibers were analyzed using microcomputed tomography, histomorphometry, immunohistomorphometry, polarized light microscopy and birefringence measurement system inside of the first and second thread (designated as thread A and B, respectively, as mechanical stresses are concentrated and differently distributed on the first two threads from the implant neck. Mechanical load significantly increased BMD, but not bone volume around implants. Inside thread B, but not thread A, mechanical load significantly accelerated Sema3A production with increased number of osteoblasts and osteocytes, and enhanced production of both type I and III collagen. Moreover, mechanical load also significantly induced preferential alignment of collagen fibers in the lower flank of thread B. These data demonstrate that mechanical load has different effects on Sema3A production and bone quality based on bone cells and collagen fibers between the inside threads of A and B. Mechanical load-induced Sema3A production may be differentially regulated by the type of bone structure or distinct stress distribution

  12. Euroopa Parlamendi ja Nõukogu direktiivi 2005/60/EÜ rahandussüsteemi rahapesu ja terrorismi rahastamise eesmärgil kasutamise vältimise ülevõtmine Baltimaades : [magistritöö] / Katrin Kuusik ; Tartu Ülikool, õigusteaduskond ; juhendaja: Rau

    Index Scriptorium Estoniae

    Kuusik, Katrin, 1984-

    2009-01-01

    Euroopa Parlamendi ja Nõukogu direktiivi 2005/60/EÜ kujunemisest ja olemusest, EL liikmesriigi tegevusest direktiivi siseriiklikusse õigusessa ülevõtmisel, ülevõtmisest Balti riikide õigusesse

  13. LDL receptor-related protein 1 regulates the abundance of diverse cell-signaling proteins in the plasma membrane proteome.

    Science.gov (United States)

    Gaultier, Alban; Simon, Gabriel; Niessen, Sherry; Dix, Melissa; Takimoto, Shinako; Cravatt, Benjamin F; Gonias, Steven L

    2010-12-03

    LDL receptor-related protein 1 (LRP1) is an endocytic receptor, reported to regulate the abundance of other receptors in the plasma membrane, including uPAR and tissue factor. The goal of this study was to identify novel plasma membrane proteins, involved in cell-signaling, that are regulated by LRP1. Membrane protein ectodomains were prepared from RAW 264.7 cells in which LRP1 was silenced and control cells using protease K. Peptides were identified by LC-MS/MS. By analysis of spectral counts, 31 transmembrane and secreted proteins were regulated in abundance at least 2-fold when LRP1 was silenced. Validation studies confirmed that semaphorin4D (Sema4D), plexin domain-containing protein-1 (Plxdc1), and neuropilin-1 were more abundant in the membranes of LRP1 gene-silenced cells. Regulation of Plxdc1 by LRP1 was confirmed in CHO cells, as a second model system. Plxdc1 coimmunoprecipitated with LRP1 from extracts of RAW 264.7 cells and mouse liver. Although Sema4D did not coimmunoprecipitate with LRP1, the cell-surface level of Sema4D was increased by RAP, which binds to LRP1 and inhibits binding of other ligands. These studies identify Plxdc1, Sema4D, and neuropilin-1 as novel LRP1-regulated cell-signaling proteins. Overall, LRP1 emerges as a generalized regulator of the plasma membrane proteome.

  14. Semaphorin 3G Provides a Repulsive Guidance Cue to Lymphatic Endothelial Cells via Neuropilin-2/PlexinD1.

    Science.gov (United States)

    Liu, Xinyi; Uemura, Akiyoshi; Fukushima, Yoko; Yoshida, Yutaka; Hirashima, Masanori

    2016-11-22

    The vertebrate circulatory system is composed of closely related blood and lymphatic vessels. It has been shown that lymphatic vascular patterning is regulated by blood vessels during development, but its molecular mechanisms have not been fully elucidated. Here, we show that the artery-derived ligand semaphorin 3G (Sema3G) and the endothelial cell receptor PlexinD1 play a role in lymphatic vascular patterning. In mouse embryonic back skin, genetic inactivation of Sema3G or PlexinD1 results in abnormal artery-lymph alignment and reduced lymphatic vascular branching. Conditional ablation in mice demonstrates that PlexinD1 is primarily required in lymphatic endothelial cells (LECs). In vitro analyses show that Sema3G binds to neuropilin-2 (Nrp2), which forms a receptor complex with PlexinD1. Sema3G induces cell collapse in an Nrp2/PlexinD1-dependent manner. Our findings shed light on a molecular mechanism by which LECs are distributed away from arteries and form a branching network during lymphatic vascular development. Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

  15. Protein: MPB4 [TP Atlas

    Lifescience Database Archive (English)

    Full Text Available MPB4 Sema3A signaling molecules DPYSL2 CRMP2, ULIP2 DPYSL2 Dihydropyrimidinase-related pr...otein 2 Collapsin response mediator protein 2, N2A3, Unc-33-like phosphoprotein 2 9606 Homo sapiens Q16555 1808 2VM8, 2GSE 1808 Q16555 ...

  16. Brain endothelial cells control fertility through ovarian-steroid-dependent release of semaphorin 3A

    NARCIS (Netherlands)

    Giacobini, Paolo; Parkash, Jyoti; Campagne, Céline; Messina, Andrea; Casoni, Filippo; Vanacker, Charlotte; Langlet, Fanny; Hobo, Barbara; Cagnoni, Gabriella; Gallet, Sarah; Hanchate, Naresh Kumar; Mazur, Danièle; Taniguchi, Masahiko; Mazzone, Massimiliano; Verhaagen, J.; Ciofi, Philippe; Bouret, Sébastien G; Tamagnone, Luca; Prevot, Vincent

    Neuropilin-1 (Nrp1) guides the development of the nervous and vascular systems, but its role in the mature brain remains to be explored. Here we report that the expression of the 65 kDa isoform of Sema3A, the ligand of Nrp1, by adult vascular endothelial cells, is regulated during the ovarian cycle

  17. OBJECT MARKING IN AFFECTIVE CONSTRUCTIONS IN SWAHILI ...

    African Journals Online (AJOL)

    Africa, all relationships between an item that can be considered to be a whole and ..... shaka, a-li-lo-li-sema without of doubt,. 1SM-Pst-5Rel-5OM-say li-li-kuwa tusi kubwa kwa ..... In M. Butt and T. H. King (Eds.), Proceedings of the LFG02 ...

  18. Immunohistochemical studies on the effect of Aloe vera on the ...

    African Journals Online (AJOL)

    Address for Correspondence. Immunohistochemical studies on the effect of Aloe vera on the pancreatic β-cells in neonatal streptozotocin-induced type-II diabetic rats. Sema Bolkent 1, Nuriye Akev 2*, Ayşe Can 2, Sehnaz Bolkent 3, Refiye Yanardag 4 &. Alper Okyar 5. 1. Department of Medical Biology, Cerrahpasa Faculty ...

  19. Chooz B1 start-up marked by total computer control

    International Nuclear Information System (INIS)

    Anon.

    1995-01-01

    The start-up of Chooz B1, the first of EdF's latest generation 1450 MWe N4 reactors, marks the first use in a nuclear power plant of a fully computerised control room. Working in partnership with EdF, Sema Group designed and supplied the advanced command and control system for this plant. (Author)

  20. Vesicular trafficking of semaphorin 3A is activity-dependent and differs between axons and dendrites

    NARCIS (Netherlands)

    de Wit, Joris; Toonen, Ruud F; Verhaagen, J.; Verhage, Matthijs

    Secreted semaphorins act as guidance cues in the developing nervous system and may have additional functions in mature neurons. How semaphorins are transported and secreted by neurons is poorly understood. We find that endogenous semaphorin 3A (Sema3A) displays a punctate distribution in axons and

  1. Le jardinage s'enracine à Governador Valadares

    International Development Research Centre (IDRC) Digital Library (Canada)

    CRDI

    À Governador Valadares, au Brésil, un programme municipal d'agriculture urbaine contribue à garnir ... taire de Bom Pastor, et qui donnent régulièrement de leurs produits aux .... COURRIEL : Sema.denilson@valadares.mg.gov.br. Avril 2006.

  2. Rewiring the taste system.

    Science.gov (United States)

    Lee, Hojoon; Macpherson, Lindsey J; Parada, Camilo A; Zuker, Charles S; Ryba, Nicholas J P

    2017-08-17

    In mammals, taste buds typically contain 50-100 tightly packed taste-receptor cells (TRCs), representing all five basic qualities: sweet, sour, bitter, salty and umami. Notably, mature taste cells have life spans of only 5-20 days and, consequently, are constantly replenished by differentiation of taste stem cells. Given the importance of establishing and maintaining appropriate connectivity between TRCs and their partner ganglion neurons (that is, ensuring that a labelled line from sweet TRCs connects to sweet neurons, bitter TRCs to bitter neurons, sour to sour, and so on), we examined how new connections are specified to retain fidelity of signal transmission. Here we show that bitter and sweet TRCs provide instructive signals to bitter and sweet target neurons via different guidance molecules (SEMA3A and SEMA7A). We demonstrate that targeted expression of SEMA3A or SEMA7A in different classes of TRCs produces peripheral taste systems with miswired sweet or bitter cells. Indeed, we engineered mice with bitter neurons that now responded to sweet tastants, sweet neurons that responded to bitter or sweet neurons responding to sour stimuli. Together, these results uncover the basic logic of the wiring of the taste system at the periphery, and illustrate how a labelled-line sensory circuit preserves signalling integrity despite rapid and stochastic turnover of receptor cells.

  3. Co-immobilization of semaphorin3A and nerve growth factor to guide and pattern axons.

    Science.gov (United States)

    McCormick, Aleesha M; Jarmusik, Natalie A; Leipzig, Nic D

    2015-12-01

    Immobilization of axon guidance cues offers a powerful tissue regenerative strategy to control the presentation and spatial location of these biomolecules. We use our previously developed immobilization strategy to specifically tether recombinant biotinylated nerve growth factor (bNGF) and biotinylated semaphorin3A (bSema3A) to chitosan films as an outgrowth and guidance platform. DRG neurite length and number for a range of single cues of immobilized bNGF or bSema3A were examined to determine a concentration response. Next single and dual cues of bNGF and bSema3A were immobilized and DRG guidance was assessed in response to a step concentration change from zero. Overall, immobilized groups caused axon extension, retraction and turning depending on the ratio of bNGF and bSema3A immobilized in the encountered region. This response indicated the exquisite sensitivity of DRG axons to both attractive and repulsive tethered cues. bSema3A concentrations of 0.10 and 0.49 ng/mm(2), when co-immobilized with bNGF (at 0.86 and 0.43 ng/mm(2) respectively), caused axons to turn away from the co-immobilized region. Immunocytochemical analysis showed that at these bSema3A concentrations, axons inside the co-immobilized region display microtubule degradation and breakdown of actin filaments. At the lowest bSema3A concentration (0.01 ng/mm(2)) co-immobilized with a higher bNGF concentration (2.16 ng/mm(2)), neurite lengths are shorter in the immobilized area, but bNGF dominates the guidance mechanism as neurites are directed toward the immobilized region. Future applications can pattern these cues in various geometries and gradients in order to better modulate axon guidance in terms of polarity, extension and branching. Nervous system formation and regeneration requires key molecules for guiding the growth cone and nervous system patterning. In vivo these molecules work in conjunction with one another to modulate axon guidance, and often they are tethered to limit spatial

  4. Ring peale kultuurkapitali kirjanduslaureaatidele

    Index Scriptorium Estoniae

    2005-01-01

    Eesti Kultuurkapitali 2004. aasta kirjanduse aastapreemia laureaatide teoste tutvustused: André Trinity (Rein Raud "Hector ja Bernard"), Mart Velsker (fs - luulekogu "2004"), Katrin Ruus (Mart Kivastik -näidend "Külmetava kunstniku portree"), Krista Kumberg (Jaan Rannap "Nelja nimega koer"), Rein Veidemann (Toomas Haug "Troojamäe tõotus")

  5. Pop / Lauri Tikerpe

    Index Scriptorium Estoniae

    Tikerpe, Lauri

    2008-01-01

    Heliplaatidest: Pastacas "Snatsit Some Si-Si", Metro Luminal "Sassis", Nitrous "Outlaw Racer", The Sun "Unisex", Laur ja Sadam "Kirjad maale", Pilvikud "Päikesepatarei", Katrin Mandel "Peegeldus", Kukerpillid & Metsatöll "Suured koerad, väiksed koerad", Ultramelanhool "Materjal"

  6. Suur rahvusvaheline välisbalti arhiivide konverents südasuvises Tartus / Mai Raud-Pähn ; fotod Madis Laas

    Index Scriptorium Estoniae

    Raud-Pähn, Mai, 1920-

    2006-01-01

    Ettekannetega esinesid: Tiiu Kravtsev, Riina Reinvelt, Juta Kivimäe, Piret Noorhani, Merike Kiipus, Anu Korb, Anne Valmas, Mihkel Volt, Mare Rand, Inga Kuljus, Enn Mainla, Roland Weiler, Teas Tanner, Tiina Kirss, Jüri Kivimäe, Enda-Mai Michelson-Holland, Andrae, Carl Göran, Katrin Meerits ja Maie Barrow

  7. Hotell Hilton Tallinn Park / Kersti Pikk

    Index Scriptorium Estoniae

    Pikk, Kersti

    2016-01-01

    Äriklassihotellide ketti Hilton kuuluv hotell Tallinnas. Arhitektuurse lahenduse autor Meelis Press. Interjööri kujundasid Soome büroo dSign Vertti Kivi & Co ja Allianss Arhitektid. Hotelli tube ja üldalasid kaunistavad Katrin Karu ja Maria Simsoni maalid

  8. Mall Hellam leiab, et ideaalidesse on vaja uskuda / Mall Hellam ; interv. Koit Luus

    Index Scriptorium Estoniae

    Hellam, Mall

    2005-01-01

    Avatud Eesti Fondi juhataja Eesti ühiskonna arengust, kodanikuühiskonnast, kodaniku mõistest ning Avatud Eesti Fondi tegevusest. Lisa: Mall Hellam. Kommenteerivad: Balti-Ameerika Partnerlusprogrammi juht Katrin Enno, Eesti Mittetulundusühingute ja Sihtasutuste Liidu juhataja Kristina Mänd ning IT Kolledzhi õppejõud, Avatud Fondi nõukogu esimees Linnar Viik

  9. Eesti Metodisti Kirik : Balti Misjoni Keskus, Narva mnt. 51, Tallinn = Estonian Methodist Church / Vilen Künnapu

    Index Scriptorium Estoniae

    Künnapu, Vilen, 1948-

    2000-01-01

    Projekteerija Arhitektuuribüroo Künnapu & Padrik. Arhitektid Vilen Künnapu, Ain Padrik. Konstruktsioonide autor Andres Laur. Sisekujundajad Argo ja Katrin Vaikla. Projekt 1994, valmis 2000. Kirik on klaasja pikliku koolitiivaga (teoloogiline seminar). 7 ill.: I korruse plaan, lõige, välis- ja sisevaated

  10. Vägivald tänapäeva noortekirjanduses / Elinor Taluste

    Index Scriptorium Estoniae

    Taluste, Elinor

    2009-01-01

    Artiklis analüüsitakse eesti keeles ilmunud noorteraamatuid, milles on kujutatud vägivalda selle eri vormides. Vaatluse all on kaks algupärandit: Sass Henno "Mina olin siin: esimene arest" ja Katrin Reimuse "Eilset pole olemas" ning kaks tõlget: Jerry Spinelli "Tähetüdruk" ja Jan Guillou` "Kurjus"

  11. Monoliitne või amorfne Eesti? / Indrek Grigor

    Index Scriptorium Estoniae

    Grigor, Indrek

    2008-01-01

    Eesti Vabariigi 90. sünnipäeva tähistav näitus "Kas me sellist Eestit tahtsime?!" Rael Artel Gallery's Tartus kuni 8. III. Kristina Normani, Flo Kasearu, Merilyn Püssi, Katrin Sarapuu, Eva Labotkini, Taavi Piibemanni ja Tanja Muravskaja töödest

  12. Talendid, kes tulid tagasi koju / Laura Mallene

    Index Scriptorium Estoniae

    Mallene, Laura

    2010-01-01

    IsePankuri asutajast Pärtel Tombergist, start-up firmaga Cutefund tegelevast Enn Metsarist, riigikantselei EL-i sekretariaadi konsultandist Katrin Juhandist, Küberkaitse Kompetentsikeskuse töötajast Anna-Maria Talihärmist, LHV Turunduse töötajast Ellen Murulast, Elioni finantsanalüütikust Artur Elmest

  13. Sisekaitseakadeemia peahoone võistlus / Ülar Mark

    Index Scriptorium Estoniae

    Mark, Ülar, 1968-

    2016-01-01

    Artiklis on antud ülevaade võistlusele esitatud töödest. Esimese preemia sai töö "Faalanks" (autorid: Illimar Truverk, Janar Toomesso, Katrin Vannas, Sander Paljak, Kristjan Lind, Hannelore Kääramees, Kaur Käärma, Siim Tiigimägi, Edgar Kaare, Terje Ong ja Liina Einla)

  14. Keelesümpoosion arutas Põhjamaade mõistet / Ülo Ignats ; fotod: Ülo Ignats

    Index Scriptorium Estoniae

    Ignats, Ülo, 1951-2011

    2006-01-01

    Stockholmis Riigipäeva teise koja saalis teemal "Kuivõrd põhjamaine on Baltikum". Ettekannetega esinesid: Kristel Zilmer, Battail, Jean-Francois Battail, Torkel Jansson, Madis Kanarbik, Stig Örjan Ohlsson, Ivars Orehovs, Erika Sausverde, Thomas Lundén, Katrin Maandi, Kristel Kääramees

  15. Dave Benton laulab Peetri kirikus / Arvo Uustalu

    Index Scriptorium Estoniae

    Uustalu, Arvo, 1964-

    2004-01-01

    Poplaulja Dave Bentoni ja Eesti Televisiooni lastekoori kontserdist 20. dets. Tartu Peetri kirikus. Peetri kirikus heategevuskontserdil "Tee rõõmsaks mind, kui sul on aega" 28. dets. laulavad Katrin Pärn, Toomas Lunge, Kait Tamra ja Indrek Kalda. Rein Rannapi viisistatud kantaati "Ilus maa" esitab Kadri Leppoja juhatusel ja Urmas Taniloo saatel M. Härma gümnaasiumi segakoor

  16. Baltic beer market : close neighbours, different situations

    Index Scriptorium Estoniae

    2004-01-01

    Baltimaade juhtivate õlletootjate marketingijuhid Martins Dzenis (Cesu Alus), Inita Drezina (Aldaris), Eriks Kalita (Livu Alus), Raimonds Kalnins (Kimmel), Dalius Rutkauskas (AB Ragutis), Dainius Smailys (Svyturis-Utenos Alus), Katrin Vernik (A. Le Coq Eesti), Karin Sepp (Saku Õlletehas) ja Härmo Põlluvee (Frederik Viru Õlu) olukorrast Baltimaade õlleturul, suurematest tarbijamängudest ja reklaamikampaaniatest. Tabelid

  17. Olla originaalne ja tähelepandud / Eve Sepp

    Index Scriptorium Estoniae

    Sepp, Eve

    1989-01-01

    Tuntud daamide originaalehetest - tekstiilikunstnik Anna Gerretzi Ülle Kõutsi valmistatud kõrvarõngad, disainer Helle Gansi Katrin Amose loodud rinnanõel, raamatukogudirektrissi Anne Randeli Tiina Käeseli loodud ehted, arhitekt Marka Lõokese Kadri Mälgu loodud komplekt, kunstiteadlase Krista Kodrese Tiina Käeseli loodud komplekt, grimeerija Krista Pärdi abikaasa Rein Metsa loodud ehted

  18. "Ekspeditsioon Wunderlich" = "Expedition Wunderlich" / Carl-Dag Lige, Hannes Praks ; kommenteerinud Triin Ojari

    Index Scriptorium Estoniae

    Lige, Carl-Dag, 1982-

    2016-01-01

    Näitus "Ekspeditsioon Wunderlich" Eesti Arhitektuurimuuseumis. Autorid Katrin Talvik, Merilin Tee, Sabine Suuster, Martin Saar, Karl Taul, Alden Jõgisuu, Tõnu Lensment, Aadam Kaarma, Cael-Dag Lige, Hannes Praks. Näitus on Eesti Kunstiakadeemia ja Eesti Arhitektuurimuuseumi ühisprojekt

  19. "Su mõte on see, mida elad" : vanadus / Kaire Nurk

    Index Scriptorium Estoniae

    Nurk, Kaire, 1960-

    2005-01-01

    Reet Varblase kuraatoriprojektist "Homo grandis natu" Tallinna Kunstihoones kuni 15. V. Tallinna Kunstikooli õpilaste (õpetaja Katrin Tukmann), Katarzyna Kozyra, Eveli Variku, Marge Monko, Piia Ruberi & Doris Kareva ja Mare Mikofi töödest, Tallinna Ülikooli audiovisuaalkunsti osakonnas tehtud filmidest (Elen Lotman, Jaak Kilmi, Kalev Hiller)

  20. Väärtustagem töötajaid

    Index Scriptorium Estoniae

    2008-01-01

    Kuidas möödus aasta 2007 ja mida toob 2008? Räägivad Järvamaa Arenduskeskuse juhataja Katrin Puusepp, Tööturuameti Järvamaa osakonna juhataja Eha Tasang, AS Comfort AE juhataja, Järva ettevõtjate seltsi president Enn Rõõs. Vt. samas: Järvamaa ettevõtlusaasta kulges mitmeti

  1. Time in the Making

    DEFF Research Database (Denmark)

    Dirckinck-Holmfeld, Katrine Remmen

    ? These are research questions Katrine Dirckinck - Holmfeld explores in the artistic research project Time in the Making: Rehearsing Reparative Critical Practices. Through the development of video installations Leap into Colour (20 12 - 2015) and movement (2012) and in dialogue with the work of artists Rania & Raed...

  2. Kopkad elamiseks : tudengite õppetoetus püsinud muutumatuna viis aastat / Signe Sillasoo, Katharina Toomemets

    Index Scriptorium Estoniae

    Sillasoo, Signe

    2007-01-01

    Tallinna Ülikooli 2. kursuse tudeng Heidi Grenzen tõdeb, et igakuiselt saadava 800 krooni eest ei ole üliõpilasel võimalik tasuda isegi ühiselamutoa eest. Ka Tartu Ülikooli tudeng Katrin Soolepp tõdeb, et õppetoetus pole äraelamiseks piisav. Esimese kursuse tudeng Elisabeth Heinsalu kinnitab sama

  3. Narvski kolledzh ostanetsja bez utshebnogo korpusa?

    Index Scriptorium Estoniae

    2007-01-01

    TÜ Narva kolledzh andis 2007. a. jaanuaris kohtusse Narva linna, sest viimane keeldub Raekoja platsile planeeritavale kolledzhi uuele õppehoonele ehitusluba väljastamast. 2005. a. avaliku arhitektuurikonkursi võitnud arhitektide Siiri Vallneri, Indrek Peili ja Katrin Koovi projekt "Vihm" on saanud heakskiidu riiklikus muinsuskaitsenõukogus ja -ametis

  4. 18. XII kell 12 kaitstakse EKA E-meedia keskuses 4 magistritööd...

    Index Scriptorium Estoniae

    2002-01-01

    Kristel Sibul "Kehatud kehad - kehad ja identiteet internetis" (juh. Katrin Kivimaa), Ivika Kivi "Virtuaalsed õpitarkvarad" (juh. Mare Emmott Tralla), Maris Lindoja "Digitaalne ruum" (juh. Andres Kurg), Raul Keller "Corporate Consulting in the Digital Age - Jamming vith the Culture" (juh. Richard Barbrook)

  5. Resonance – Journal of Science Education | Indian Academy of ...

    Indian Academy of Sciences (India)

    Jürgen Drissner1 Hans-Martin Haase2 Mara Nikolajek1 Katrin Hille3. Botanical Garden, University of Ulm, D–89081 ULM, Germany. University of Education, Oberbettringer Str. 200, D–73525 Schwäbisch Gmünd, Germany. Transfercenter for Neuroscience and Learning, University of Ulm, Beim Alten Fritz 2 D–89075 ULM, ...

  6. Kurtna keskusehoone renoveerimine = Renovation of the Kurtna center building / Epp Lankots

    Index Scriptorium Estoniae

    Lankots, Epp, 1976-

    2005-01-01

    Saku vallas Kurtna külas asuva Kurtna Linnukasvatuse Katsejaama peahoone (arhitekt Valve Pormeister, sisearhitektid Vello Asi ja Väino Tamm, 1965-66) pieteeditundelisest renoveerimisest hotelliks. Arhitektid: Heli Ernesaks, Katrin Rannik. Halvast ja odavast interjöörikujundusest. Ill.: 3 värv. välis- ja 3 sisevaadet

  7. Vanilla Ninjast saab vene bänd / Viktoria Ladõnskaja

    Index Scriptorium Estoniae

    Ladõnskaja, Viktoria, 1981-

    2007-01-01

    Plaadifirmalt Topten Vanilla Ninja lepingu ära ostnud jurist Aleksander Simakov kuulutab välja konkursi bändi uute tüdrukute leidmiseks, bänd koosseisus Piret Järvis, Lenna Kuurmaa ja Katrin Siska kavatsevad ka Vanilla Ninja nime all jätkata

  8. "Backdoor" kunstnikku testimas / Rael Artel

    Index Scriptorium Estoniae

    Artel, Rael, 1980-

    1999-01-01

    Festival "Backdoor media'99" alapealkirjaga 'Fassaadid kodututele' Tallinnas. Performance Tammsaare monumendi juures (kuraator Hanno Soans), Silja Saarepuu video kerjamiskarpidest, Andrus Kõresaare ja Jouni Partaneni videod kerjustest, Marko Raadi dokumentaalfilm 'Esteetilistel põhjustel' (peaosas Andres Kurg), tekstikogumik ehk samizdat (toimetaja Katrin Kivimaa).

  9. "Interstanding 3" põlgab trendi ja mainstream'i

    Index Scriptorium Estoniae

    1999-01-01

    Kolmas rahvusvaheline meediakunsti festival "Interstanding 3", mille teema on "Ülalpool piire". Selle raames Kaasaegse Kunsti Eesti Keskuse 6. aastanäitus, loengud, konverents "Ülalpool piire". Esinevad Saskia Sassen Chicagost, Katrin Kivimaa, Ando Keskküla, Eric Kluitenberg Amsterdamist.

  10. Tuult tiibadesse

    Index Scriptorium Estoniae

    Mikomägi, Margus, 1956-

    2009-01-01

    Autori arvates on 2009. a. suve teatripildis selline etendus, millel on pikk järelmõju, Katrin Saukase kirjutatud ja lavastatud lugu "Tuult tiibadesse", mida mängiti Hüüru mõisas, ühenduse R.A.A.A.M. eestvõtmisel ja toel

  11. Interventsiooni paratamatus kaheksa aastat hiljem = The Inevitability of Intervention Eight Years Later / Epp Lankots

    Index Scriptorium Estoniae

    Lankots, Epp, 1976-

    2008-01-01

    Uue ning vana arhitektuuri koostoimimisest Eestis. Näiteks toodud hotelli "Telegraaf" juurdeehitus (arhitekt Martin Aunin), nelikmaja (AB Kosmos, 2007) Rotermanni kvartalis, Fahle Maja (KOKO Arhitektid, 2002-2006) Tallinnas, Pärnu kesklinna koolide võimla (Kavakava, 2004-2006), TÜ Narva Kolledzhi 2006. a. arhitektuurikonkursi võidutöö (arhitektid Siiri Vallner, Katrin Koov, Indrek Peil). Bibliograafia lk. 19

  12. Mida sina täna õppisid? / Veikko Täär, Ain Aaviksoo, Ingrid Tõniste ... [jt.

    Index Scriptorium Estoniae

    2012-01-01

    Oma õppimistest ja tulevikuplaanidest räägivad näitleja ja ettevõtja Veikko Täär, tervishoiuteadlane Ain Aaviksoo, tegevjuht Ingrid Tõniste, TV3 avalike suhete juht ja uudisteankur Anneli Adermann, arenduskonsultant Anu Puusaag, personaaltreener Katrin Pärt ja loodusarst Tiina Keldrima

  13. Aasta parimad interjöörid / Mart Kalm

    Index Scriptorium Estoniae

    Kalm, Mart, 1961-

    2005-01-01

    Eesti Sisearhitektide Liidu aastapreemiad 2004. Võidutööd: Tartu Mänguasjamuuseum (Tea Tammelaan, Krista Lepland, Malle Jürgenson, OÜ Laika, Belka & Strelka); Emil Urbeli projekteeritud kastvilla Miidurannas (Argo Vaikla, Katrin Vaikla, Tiina Teng); Georg Ots Spa hotell Kuressaares (Liisi Murula, Raili Paling). Esemepreemia pälvis Toivo Raidmetsa tool "John", tegevuspreemia sai Maile Grünberg

  14. Nädal pakub kolme näituse jagu eesti nüüdisaegset kunsti / Mart Niineste

    Index Scriptorium Estoniae

    Niineste, Mart, 1983-

    2011-01-01

    Mihkel Kleisi uusima maaliloomingu näitus "Guts´n´Roses" Tallinnas Hobusepea galeriis. Graafik Silvi Liiva näitus "Piirideta" Tallinna Kunstihoone galeriis. Katrin ja Peeter Pere ühisnäitus "Laoseis" Tallinnas Tõnismäel Parikase majas

  15. Living with a parasite / Elo-Hanna Seljamaa

    Index Scriptorium Estoniae

    Seljamaa, Elo-Hanna, 1980-

    2004-01-01

    Ehtekunstnike Kärt Marani (s. 1980), Argo Männiku (s. 1977), Bruno Lillemetsa (s. 1979), Sven Tali, Ester Faimani (s. 1975), Maarja Niinemäe ja Katrin Veegeni näitus "Tallinna lennuväli : anti-venenos"

  16. Ettevõtted panustavad eelarve koostamisel järjest enam spetsialistide täiendkoolitusse / Madli Kents

    Index Scriptorium Estoniae

    Kents, Madli

    2005-01-01

    AS-i Kalev koolitusspetsialist Gerli Jõgi, Hansapanga koolituse ostujuht Katrin Kase ja AS-i Eesti Energia koolitusjuht Erge Heido selgitavad, millele pööratakse tähelepanu nende ettevõttes koolituseelarve koostamisel ning annavad ülevaate rakendatavatest koolitusvormidest. Vt. samas: Marja Liis. Esiplaanil on teenindajad

  17. Arstide koolitus vaakumis / Triin Tabur

    Index Scriptorium Estoniae

    Tabur, Triin

    2014-01-01

    Arstide täienduskoolituse fondi tulumaksusoodustustega ühenduste nimekirjast välja jätmine on arstide erialase täienduskoolituse välismaal jätnud stipendiumiteta. Selgitusi jagavad Katrin Rehemaa, Margus Viigimaa, Tiina Sats ja Toomas Pruunsild

  18. Uue tantsu Superinimene / Ivar Põllu

    Index Scriptorium Estoniae

    Põllu, Ivar

    2007-01-01

    Festivalil "Uue tantsu nädal Tartus " esitatud viiest autorilavastusest : Katrin Essensoni "Manusega mõtted", Renate Valme "Mesta", Mart Kangro "Start. Based on a True Story", Kaja Kannu "There are Laika Dogs living in Estonia" ja Marten Spangbergi "Heja Sverige"

  19. Isad ja tütred, isad ja pojad / Jüri Ross, Kristine Ross, Fjodor Berman ...[jt.] ; üles kirjutanud Jaana Liigand

    Index Scriptorium Estoniae

    2011-01-01

    Büroomaailma juht Jüri Ross ja turundusdirektor Kristine Ross, BLRT Grupi omanik Fjodor Berman ja BLRT Grupi tütarfirma Refonda tegevdirektor Mark Berman, Saaremaa Laevakompanii ja paljude firmade omanik Vjatšeslav Leedo ja Mosaiigi kohviku omanik Katrin Leedo ärist, juhtimisest ja omavahelistest suhetest

  20. 1 küsimus noorele juhile : Mis teha, kui kopp on ees - kuidas sa stressist jagu saad? / Riho Jürvetson, Merit Miller, Krister Rekkaro ... [jt.

    Index Scriptorium Estoniae

    2009-01-01

    Küsimusele vastavad EMT erakliendi osakonna juhataja Riho Jürvetson, KPMG Baltics müügijuht Merit Miller, ArtPrint juht Krister Rekkaro, Dateli juhatuse liige Triin Sepp, Media House projektijuht Tanel Tarkmees, Ober-Haus Kinnisvara tegevjuht Katrin Klein-Näppi