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Sample records for selektivnoe vydelenie 67cu

  1. [Purification of 67Cu]. Progress report

    International Nuclear Information System (INIS)

    DeNardo, S.J.

    1994-01-01

    This report documents progress made in several areas of research and describes results which have not yet been published. These areas include: Purification of 67 Cu; Macrocyclic chelates for targeted therapy; Studies of biologic activation associated with molecular receptor increase and tumor response in ChL6/L6 protocol patients; Lym-1 single chain genetically engineered molecules; Analysis of molecular genetic coded messages to enhance tumor response; Human dosimetry and therapeutic human use radiopharmaceuticals; studies in phantoms; Quantitative SPECT; Preclinical studies; and Clinical studies

  2. New production cross sections for the theranostic radionuclide 67Cu

    Science.gov (United States)

    Pupillo, Gaia; Sounalet, Thomas; Michel, Nathalie; Mou, Liliana; Esposito, Juan; Haddad, Férid

    2018-01-01

    The cross sections of the 68Zn(p,2p)67Cu, 68Zn(p,2n)67Ga and 68Zn(p,3n)66Ga reactions were measured at the ARRONAX facility by using the 70 MeV cyclotron, with particular attention to the production of the theranostic radionuclide 67Cu. Enriched 68Zn material was electroplated on silver backing and exposed to a low-intensity proton beam by using the stacked-foils target method. Since 67Cu and 67Ga radionuclides have similar half-lives and same γ-lines (they both decay to 67Zn), a radiochemical process aimed at Cu/Ga separation was mandatory to avoid interferences in γ-spectrometry measurements. A simple chemical procedure having a high separation efficiency (>99%) was developed and monitored during each foil processing, thanks to the tracer isotopes 61Cu and 66Ga. Nuclear cross sections were measured in the energy range 35-70 MeV by using reference reactions recommended by the International Atomic Energy Agency (IAEA) to monitor beam flux. In comparison with literature data a general good agreement on the trend of the nuclear reactions was noted, especially with latest measurements, but slightly lower values were obtained in case of 67Cu. Experimental results of the 68Zn(p,2p)67Cu, 68Zn(p,2n)67Ga and 68Zn(p,3n)66Ga reactions were also compared with the theoretical values estimated by using the software TALYS. The production yield of the theranostic radionuclide 67Cu was estimated considering the results obtained in this work.

  3. Effect of 67Cu and 99Mo labeled tetrathiomolybdate on the distribution of 67Cu, Cu, and 99Mo in bile fractions in sheep

    International Nuclear Information System (INIS)

    Gooneratne, R.; Laarveld, B.; Christensen, D.

    1989-01-01

    The effect of intravenous administration of 67 Cu and 99 Mo labeled tetrathiomolybdate (TTM) on the appearance of 67 Cu, stable Cu, and 99 Mo in gel chromatographic fractions of bile was examined in sheep fed either 5 or 35 mg Cu kg-1 DM. Peak excretory periods of biliary 67 Cu, stable Cu, and 99 Mo were observed at 30 min-1.25 hr, 2-3 hr, and 11-13 hr after 67 Cu and after 99 Mo labeled TTM. Sephadex G-75 gel filtration of bile samples collected at 1, 3, and 12 hr after 67 Cu administration revealed two major protein peaks of molecular weights of greater than 80,000 (peak I) and 7,000 (peak II) containing both 67 Cu and Cu. But the ratio of 67 Cu in the two peaks varied with time of bile collection. The ratio of areas of peak I:II 1 hr after 67 Cu administration was approximately 0.48; at 3 hr, 0.62, and at 12 hr 1.35. Tetrathiomolybdate administration increased both 67 Cu and stable Cu in bile by severalfold and induced a major shift of Cu into the higher molecular weight protein fraction. The experiments confirm the effectiveness of TTM as a ''decoppering'' agent. Furthermore, TTM not only promoted bile Cu excretion, but it also increased the incorporation of Cu into the macromolecular fraction. This may limit enterohepatic circulation of biliary Cu and thereby cause an overall Cu depletion and a negative Cu balance

  4. Transfer of copper from a chelated 67Cu-antibody conjugate to ceruloplasmin in lymphoma patients

    International Nuclear Information System (INIS)

    Mirick, Gary R.; O'Donnell, Robert T.; DeNardo, Sally J.; Shen Sui; Meares, Claude F.; DeNardo, Gerald L.

    1999-01-01

    The Lym-1 monoclonal antibody was conjugated with the bifunctional chelating agent 6-[p-(bromoacetamido)benzyl]-1,4,8,11-tetraazacyclotetradecane-N,N',N'',N' -tetraacetic acid (BAT), using 2IT as a linker, and radiolabeled with 67 Cu to make the radiopharmaceutical, 67 Cu-2IT-BAT-Lym-1. Ten patients received a total of 18 doses of 67 Cu-2IT-BAT-Lym-1 as targeted, systemic radiotherapy. The beta phase of blood clearance, when corrected for 67 Cu decay, was positive or flat, a phenomenon not observed in similar patients treated with 131 I-Lym-1. The flat beta phase of blood clearance suggested recycling of 67 Cu from 67 Cu-2IT-BAT-Lym-1 to another plasma protein. Therefore, the amount of 67 Cu transferred from the radiopharmaceutical to CP, Alb, and TF was measured using affinity-purified polyclonal antibodies. The fraction of plasma 67 Cu precipitated by anti-human CP increased daily; most blood radioactivity was 67 Cu-CP after a median of 4 days (range 2-7 days). The transfer of 67 Cu to CP was observed in all patients and was consistent from dose to dose within the same patient. An average of 2.8±1.5% (range 0.8-7.8%) of the 67 Cu dose (%ID) was transferred to CP. The release rate of 67 Cu-CP from the liver into the blood was 0.9±0.4 %ID/day for the first 3 days. The 67 Cu-CP effective clearance half-life was 3.7 ± 0.7 days. Subtraction of the 67 Cu-CP activity from the total blood radioactivity yielded a biphasic blood clearance similar to that obtained for patients given 131 I-Lym-1. Cu-67-CP increased the AUC for whole blood by 24 ± 10%. The %ID of 67 Cu recycled correlated with GGT, ALT, and alkaline phosphatase levels; r=0.958 (p 67 Cu-2IT-BAT-Lym-1 and recycles a small fraction of the 67 Cu, transferring it to CP

  5. Preparation of carrier-free 67Cu by the 68Zn(γ,p) reaction

    International Nuclear Information System (INIS)

    Yagi, M.; Kondo, K.

    1978-01-01

    The preparation of pure, carrier-free 67 Cu using the 68 Zn(γ, p) reaction with an isotopically enriched 68 Zn(98.97%) target is described. The production rates of 67 Cu and contaminants were determined as a function of the maximum bremsstrahlung energies between 30 and 60 MeV. The chemical separation of the carrier-free 67 Cu and the recovery of the 68 Zn target were also studied. (author)

  6. New Production Routes for Medical Isotopes 64Cu and 67Cu Using Accelerator Neutrons

    Science.gov (United States)

    Kin, Tadahiro; Nagai, Yasuki; Iwamoto, Nobuyuki; Minato, Futoshi; Iwamoto, Osamu; Hatsukawa, Yuichi; Segawa, Mariko; Harada, Hideo; Konno, Chikara; Ochiai, Kentaro; Takakura, Kosuke

    2013-03-01

    We have measured the activation cross sections producing 64Cu and 67Cu, promising medical radioisotopes for molecular imaging and radioimmunotherapy, by bombarding a natural zinc sample with 14 MeV neutrons. We estimated the production yields of 64Cu and 67Cu by fast neutrons from \\text{natC(d,n) with 40 MeV 5 mA deuterons. We used the present result together with the evaluated cross section of Zn isotopes. The calculated 64Cu yield is 1.8 TBq (175 g 64Zn) for 12 h of irradiation; the yields of 67Cu by 67Zn(n,p)67Cu and 68Zn(n,x)67Cu were 249 GBq (184 g 67Zn) and 287 GBq (186 g 68Zn) at the end of 2 days of irradiation, respectively. From the results, we proposed a new route to produce 67Cu with very little radionuclide impurity via the 68Zn(n,x)67Cu reaction, and showed the 64Zn(n,p)64Cu reaction to be a promising route to produce 64Cu. Both 67Cu and 64Cu are noted to be produced using fast neutrons.

  7. Effect of age and lactose on 67Cu utilization in rats

    International Nuclear Information System (INIS)

    Link, J.; Dowdy, R.; Michelmann, E.; Hill, G.; Zinn, K.; Trrokey, D.; Ellersieck, M.

    1991-01-01

    Young and old male Fischer 344 rats were fed a control diet or a lactose diet. After four weeks rats were gavaged with approximately 6.24 uCl 67 Cu, placed in metabolism cages, and fed their respective diets for an additional two weeks. Daily whole body, urine and fecal radioactivity measurements were made. Rats were killed on day 42 and livers removed for radioactivity determination. Diet had no effect on whole body retention of 67 Cu in the old rats; approximately 20% of the initial dose was retained by the end of the study. In the young rats, however, lactose appeared to enhance initial 67 Cu retention; by day three young control rats retained only 30% of the initial dose, while the young lactose rats retained about 50%. Retention of 67 Cu at the end of the study was approximately 15% and 20% for young control and young lactose rats, respectively. During the first four days post dosing, cumulative fecal 67 Cu excretion was approximately 83% for young control rats and 69% for young lactose rats indicating enhancement of 67 Cu absorption by lactose in the young rats. For old rats cumulative 67 Cu excretion in feces was about 50% regardless of diet. Cumulative urinary 67 Cu excretion was approximately 6% and 8% for young control and lactose rats, respectively vs about 11% for old rats. 67 Cu retention in liver was greater in old rats regardless of diet. The early increase in 67 Cu absorption after a bolus dose may have therapeutic implications. In light of current concern regarding Cu-carbohydrate interactions, the apparent enhancement Cu retention by lactose in young rats deserves further attention

  8. The influence of dietary Cu and diabetes on tissue 67Cu retention kinetics in rats

    International Nuclear Information System (INIS)

    Uriu-Hare, J.Y.; Rucker, R.B.; Keen, C.L.

    1991-01-01

    Compared to controls, diabetes results in higher plasma, liver and kidney Cu concentrations. Since alterations in Cu metabolism may be associated with diabetic pathology, the authors investigated how Cu metabolism is affected by diabetes and dietary Cu intake. Nondiabetic and STZ diabetic rats were fed Cu suppl. or Cu def. diets for 5 wks. Rats were intubated with 28 μCi 67 Cu and killed after 8, 16, 24, 32, 64, or 128 h. There were marked effects of both diet and diabetes on 67 Cu metabolism. Independent of diabetes, deficient rats had a higher % of retained 67 Cu, in liver, plasma, RBC, muscle, spleen, brain, lung, uterus, and intestine than adequate Cu rats. Independent of dietary Cu, diabetic rats had a lower % of retained 67 Cu in liver, plasma, RBC, muscle, spleen, lung, bone, pancreas, skin, uterus and heart than controls. Differential effects were noted for kidney; adequate Cu diabetic rats had a higher % of retained 67 Cu than all other groups. Marked effects of both diet and diabetes were evident when tissue Cu turnover was examined. Compared to Cu suppl. rats, Cu def. rats had a slower turnover of 67 Cu, in liver, plasma, intestine, pancreas, eye, brain, muscle, spleen, lung and heart. Diabetic rats had a slower turnover of 67 Cu than nondiabetic rats in liver, plasma, intestine, pancreas, eye, kidney, RBC and uterus. The data imply that a focus on Cu metabolism with regard to cellular Cu trafficking and pathology may be warranted

  9. Mathematical modeling and multicriterion optimization for photonuclear production of the 67cu isotope

    International Nuclear Information System (INIS)

    Dikij, N.P.; Rudychev, Y.V.; Fedorchenko, D.V.; Khazhmuradov, M.A.

    2014-01-01

    This paper considers a method for 67 Cu isotope production using electron bremsstrahlung by the 68 Zn(gamma, p) 67 Cu reaction. The facility for 67 Cu isotope production contains an electron accelerator, electron-gamma converter and zinc target. To optimize this facility we developed three-dimensional model of the converter and the target. Using this model, we performed the mathematical modeling of zinc target irradiation and thermal-hydraulic processes inside the target for various parameters of the electron beam and converter configurations. For mathematical modeling of radiation processes we used the MCNPX software. Thermal-hydraulic simulation utilized the commercial SolidWorks software with Flow Simulation module. Mathematical modeling revealed that efficient 67 Cu isotope production needs smaller beam diameter and higher electron energy. Under these conditions target heat power also increases, thus additional cooling is necessary. If the beam diameter and the electron energy are fixed the most effective method to satisfy the operating parameters and retain an efficient isotope yield is to optimize photonuclear spectra of the target by variation of converter thickness. We developed an algorithm for multicriterion optimization and performed the optimization of the facility with account to coupled radiation and heat transfer processes.

  10. Target development for 67Cu, 82Sr radionuclide production at the RIC-80 facility

    Science.gov (United States)

    Panteleev, V. N.; Barzakh, A. E.; Batist, L. Kh.; Fedorov, D. V.; Ivanov, V. S.; Krotov, S. A.; Molkanov, P. L.; Moroz, F. V.; Orlov, S. Yu.; Volkov, Yu. M.

    2018-01-01

    A high-current cyclotron C-80 capable of producing 40-80 MeV proton beams with a current of up to 200 μA has been constructed and commissioned at PNPI (Petersburg Nuclear Physics Institute). One of the main goals of cyclotron C-80 is the production of a wide spectrum of medical radionuclides for diagnostics and therapy. To date, the project development of a radioisotope facility RIC-80 (radioisotopes at cyclotron C-80) has been completed. The feature of the project is the use of a mass-separator combined with the ion-target device for obtaining ion beams of radioisotopes with a high purity of separation that is especially important for medical applications. The first results of a new high-temperature method for extracting 82Sr and 67Cu radioisotopes from irradiated targets have been presented.

  11. Synthesis of 3,5-diisopropyl[carboxy-14C]salicylic acid and its 67Cu complex

    International Nuclear Information System (INIS)

    Chidambaram, M.V.; Epperson, C.E.; Williams, S.; Gray, R.A.; Sorenson, J.R.J.

    1991-01-01

    The synthesis of 3,5-diisopropyl[carboxy- 14 C]salicylic acid was achieved via Kolbe-Schmitt carboxylation of potassium 2,4-di-isopropylphenolate. The yield of this acid was 81% based upon the weight of the product and 93% based upon radioactivity incorporated into the labeled acid which contains 98% 14 C in the carboxyl group (specific activity = 5.1 μCi/mg). The labeled acid was characterized by ultraviolet spectrophotometry and purity established by thin-layer chromatography, autoradiography, and liquid scintillation counting. A 90% yield of the double labeled 14 C, 67 Cu-complex (specific activity = 4.6 μCi 67 Cu/mg) was obtained using conditions developed with non-radioactive reactants. The presence of 67 Cu in this complex was established using γ-ray emission spectrophometry. (author)

  12. Using 67Cu to study the biogeochemical cycling of copper in the northeast subarctic Pacific Ocean

    Directory of Open Access Journals (Sweden)

    David M Semeniuk

    2016-06-01

    Full Text Available Microbial copper (Cu nutrition and dissolved Cu speciation were surveyed along Line P, a coastal to open ocean transect that extends from the coast of British Columbia, Canada, to the high-nutrient-low-chlorophyll (HNLC zone of the northeast subarctic Pacific Ocean. Steady-state size fractionated Cu uptake rates and Cu:C assimilation ratios were determined at in situ Cu concentrations and speciation using a 67Cu tracer method. The cellular Cu:C ratios that we measured (~30 µmol Cu mol C-1 are similar to recent estimates using synchrotron x-ray fluorescence (SXRF, suggesting that the 67Cu method can determine in situ metabolic Cu demands. We examined how environmental changes along the Line P transect influenced Cu metabolism in the sub-microplankton community. Cellular Cu:C assimilation ratios and uptake rates were compared with net primary productivity, bacterial abundance and productivity, total dissolved Cu, Cu speciation, and a suite of other chemical and biological parameters. Total dissolved Cu concentrations ([Cu]d were within a narrow range (1.46 to 2.79 nM, and Cu was bound to a ~5-fold excess of strong ligands with conditional stability constants ( of ~1014. Free Cu2+ concentrations were low (pCu 14.4 to 15.1, and total and size fractionated net primary productivity (NPPV; µg C L-1 d-1 were negatively correlated with inorganic Cu concentrations ([Cu′]. We suggest this is due to greater Cu′ drawdown by faster growing phytoplankton populations. Using the relationship between [Cu′] drawdown and NPPV, we calculated a regional photosynthetic Cu:C drawdown export ratio between 1.5 and 15 µmol Cu mol C-1, and a mixed layer residence time (2.5 to 8 years that is similar to other independent estimates (2-12 years. Total particulate Cu uptake rates were between 22 and 125 times faster than estimates of Cu export; this is possibly mediated by rapid cellular Cu uptake and efflux by phytoplankton and bacteria or the effects of grazers and

  13. Ocular trace metal kinetics and toxicology. I. The distribution of intravitreally injected 67Cu++ within intraocular compartments and its loss from the globe

    International Nuclear Information System (INIS)

    Bito, L.Z.; Baroody, R.A.

    1987-01-01

    Radioactive copper (67Cu++) was injected into the center of the vitreous body of rabbits. The relatively rapid initial loss of 67Cu from the vitreous was associated with its accumulation in intraocular tissues. At 24 hr, 20% of the injected 67Cu was found in the retina, representing the highest 67Cu concentration among all ocular tissues, and this high 67Cu concentration was maintained in this tissue throughout the 10-day observation period. Significant amounts of 67Cu were not detected in the aqueous humor at any time. About one-half of the injected 67Cu was lost from the whole globe in 5 days, but the remaining Cu was retained in the globe during the next 5 days. Eyes that received a large dose of CuSO4 in addition to the tracer showed decreased 67Cu activity in the retina and a slight increase in the aqueous humor. Endotoxin-induced ocular inflammation decreased the rate of 67Cu loss from the vitreous, reduced its accumulation by the retina, and increased 67Cu entry into the aqueous humor. It is concluded that 67Cu is retained in the vitreous and the globe due to its binding by, and/or uptake into, intraocular tissues, especially the retina. Cu does not effectively enter the anterior chamber from the vitreous, apparently due to its effective removal by the ciliary processes, thus ruling out the possibility of identifying the existence of Cu-containing intraocular foreign bodies in the posterior segment of the eye by analysis of Cu in the aqueous humor

  14. Variations in plasma ceruloplasmin and whole body retention of 67Cu in guinea pigs recovering from vitamin C deficiency

    International Nuclear Information System (INIS)

    Hosestenbach, R.D. Jr.; Harris, E.D.

    1991-01-01

    Parallels may be drawn between the symptoms of scurvy and copper deficiency. This realization led the authors to examine the effects of ascorbic acid supplementation on plasma ceruloplasmin and whole body turnover of copper in scorbutic guinea pigs. Weanling guinea pigs were fed an ascorbate free semi-purified diet for 10-14 days then randomly divided into 3 treatment groups receiving oral supplementation of ascorbic acid at levels: deficient, normal, and excess. In two experiments with different groups of animals, the plasma ceruloplasmin IU, measured by p-phenylenediamine oxidase activity, was significantly higher in the deficient groups, 53.5 ± 7.7 and 41.2 ± 9.2, than in the normal and excess groups, 18.3 ± 7.7, 21.6 ± 2.6 and 30.2 ± 9.2, 18.3 ± 2.6, respectively. 67 Cu was administered intraperitoneally and whole body gamma radiation was measured at 24 h intervals to determine excretion and retention rates of the 3 treatment groups. A higher retention of 67 Cu was observed in the deficient group, t1/2 = 4.8 days compared to 2.6 and 1.6 in the normal and excess groups, respectively. The affect of ascorbic acid on the regulatory mechanism of copper retention, either directly or indirectly, and the increase in plasma ceruloplasmin activity indicates ascorbic acid may perform a functional role in copper utilization in a biological system

  15. Measurement of the $\\beta$-asymmetry parameter of $^{67}$Cu in search for tensor type currents in the weak interaction

    CERN Document Server

    Soti, G.; Breitenfeldt, M.; Finlay, P.; Herzog, P.; Knecht, A.; Köster, U.; Kraev, I.S.; Porobic, T.; Prashanth, P.N.; Towner, I.S.; Tramm, C.; Zákoucký, D.; Severijns, N.

    2014-01-01

    Precision measurements at low energy search for physics beyond the Standard Model in a way complementary to searches for new particles at colliders. In the weak sector the most general $\\beta$ decay Hamiltonian contains, besides vector and axial-vector terms, also scalar, tensor and pseudoscalar terms. Current limits on the scalar and tensor coupling constants from neutron and nuclear $\\beta$ decay are on the level of several percent. The goal of this paper is extracting new information on tensor coupling constants by measuring the $\\beta$-asymmetry parameter in the pure Gamow-Teller decay of $^{67}$Cu, thereby testing the V-A structure of the weak interaction. An iron sample foil into which the radioactive nuclei were implanted was cooled down to milliKelvin temperatures in a $^3$He-$^4$He dilution refrigerator. An external magnetic field of 0.1 T, in combination with the internal hyperfine magnetic field, oriented the nuclei. The anisotropic $\\beta$ radiation was observed with planar high purity germanium d...

  16. Uptake, retention and excretion of strontium in man; Assimilation, retention et excretion du strontium chez l'homme; Pogloshchenie, zaderzhka i vydelenie strontsiya organizmom cheloveka; Absorcion, retencion y excrecion del estroncio en el hombre

    Energy Technology Data Exchange (ETDEWEB)

    Harrison, G. E. [Radiobiological Research Unit, Medical Research Council, Harwell (United Kingdom)

    1963-02-15

    estroncio en el esqueleto y sugiere que existen por lo menos tres grados de fijacion del estroncio radiactivo en los huesos. Estudia particularmente la retencion despues de varios meses de aplicada la dosis y la relacion existente entre esta retencion y la dosis de radiacion de {sup 90}Sr recibida por el esqueleto. Propone por ultimo una formula para evaluar la retencion en el organismo de una dosis de estroncio radiactivo a partir del valor de la radiactividad excretada con la orina. (author) [Russian] Obsuzhdaetsya vopros o vsasyvanii strontsiya iz zheludochno-kishechnogo trakta v svyazi s dietoj i razlichnymi komponentami khlebnomolochnoj diety. Privodyatsya rezul'taty, poluchennye pri ispol'zovanii kompleksnykh soedinenij, i diety s vysokim soderzhaniem kal'tsiya dlya umen'sheniya pogloshcheniya strontsiya. Obsutdaetsya sootnoshenie strontsiya i kal'tsiya v razlichnykh chastyakh tela u vzroslogo cheloveka. Privodyatsya rezul'taty nedavnikh ehksperimental'nykh issledovanij, provedennykh u zdorovykh lyudej na postoyannoj diete, pri ehtom osoboe vnimanie udelyaetsya vydeleniyu s mochoj i zaderzhke strontsiya-85, soderzhashchegosya v ehksperimental'noj diete. Opredelyalos' takzhe ehndogennoe vydelenie s ehkskrementami. Ehti dannye sravnivayutsya s rezul'tatami, poluchennymi pri odnokratnom vnutrivennom vvedenii radioaktivnogo strontsiya. Vo vsekh sluchayakh uderzhanie strontsiya opoedelyalos' izmereniem radioaktivnosti vsego organizma s pomoshch'yu amplitudnogo analizatora impul'sov. Analiziruyutsya prichiny ehaderkhki strontsiya a' skelete i postiliruetsya, chto imeyutsya, po krajnej meretri stepeni svyazi radioaktivnogo strontsiya s kostyami. Obsukhdaetsya, v chastnosti, zaderkhka izotopa v techenie neskol'kikh mesyatsev posle ego vvedeniya, a tayue svyaz' ehtoj zaderzhki s dozoj oblucheniya, poluchaemoj skeletom ot strontsiya-90. Predlagaetsya formula dlya opredeleniya uderzhaniya organizmom radioaktivnoj dozy strontsiya v zavisimosti ot radioaktivnosti, vydelyaemoj s

  17. Nuclear data for production of the therapeutic radionuclides {sup 32}P, {sup 64}Cu, {sup 67}Cu, {sup 89}Sr, {sup 9}Y and {sup 153}Sm via the (n,p) reaction: Evaluation of excitation function and its validation via integral cross-section measurement using a 14 MeV d(Be) neutron source

    Energy Technology Data Exchange (ETDEWEB)

    Al-Abyad, M. [Institut fuer Nuklearchemie, Forschungszentrum Juelich GmbH, D-52425 Juelich (Germany); Cyclotron Facility, Nuclear Research Center, Atomic Energy Authority, Cairo 13759 (Egypt); Spahn, I. [Institut fuer Nuklearchemie, Forschungszentrum Juelich GmbH, D-52425 Juelich (Germany); Institute of Experimental Physics, University of Debrecen, H-4010 Debrecen (Hungary); Sudar, S. [Institut fuer Nuklearchemie, Forschungszentrum Juelich GmbH, D-52425 Juelich (Germany); Institute of Experimental Physics, University of Debrecen, H-4010 Debrecen (Hungary); Morsy, M. [Cyclotron Facility, Nuclear Research Center, Atomic Energy Authority, Cairo 13759 (Egypt); Comsan, M.N.H. [Cyclotron Facility, Nuclear Research Center, Atomic Energy Authority, Cairo 13759 (Egypt); Csikai, J. [Institute of Experimental Physics, University of Debrecen, H-4010 Debrecen (Hungary); Qaim, S.M. [Institut fuer Nuklearchemie, Forschungszentrum Juelich GmbH, D-52425 Juelich (Germany)]. E-mail: s.m.qaim@fz-juelich.de; Coenen, H.H. [Institut fuer Nuklearchemie, Forschungszentrum Juelich GmbH, D-52425 Juelich (Germany)

    2006-06-15

    Nuclear data for production of the therapeutic radionuclides {sup 32}P, {sup 64}Cu, {sup 67}Cu, {sup 89}Sr, {sup 9}Y and {sup 153}Sm via (n,p) reactions on the target nuclei {sup 32}S, {sup 64}Zn, {sup 67}Zn, {sup 89}Y, {sup 9}Zr and {sup 153}Eu, respectively, are discussed. The available information on each excitation function was analysed. From the recommended data set for each reaction the average integrated cross section for a standard 14 MeV d(Be) neutron field was deduced. The spectrum-averaged cross section was also measured experimentally. A comparison of the integrated value with the integral measurement served to validate the excitation function within about 15%. A fast neutron source appears to be much more effective than a fission reactor for production of the above-mentioned radionuclides in a no-carrier-added form via the (n,p) process. In particular, the possibility of production of high specific activity {sup 153}Sm is discussed.

  18. 67Cu-labelled antibody fragments for RIT: strategies to prevent kidney accumulation of 67Cu-labelled metabolites

    International Nuclear Information System (INIS)

    Rutherford, R.A.D.; Zimmermann, K.; Waibel, R.; Ruch, C.; Pasquale, C. de; Novak-Hofer, I.

    1997-01-01

    Two different approaches to reduce accumulation of radiocopper labelled metabolites in the kidney were pursued. The first strategy consisted of pharmacological blockade of reuptake of metabolites by predosing with basic amino acids. The second approach is chemical modification of the DOTA chelator in an attempt to increase clearance of metabolites from the kidneys. (author) 1 fig., 1 ref

  19. Evaluation of Some (n,n'), (n,γ), (n,p), (n,2n) and (n,3n) Reaction Excitation Functions for Fission and Fusion Reactor Dosimetry Applications; Evaluation of the Excitation Functions for the 54Fe(n,p)54Mn, 58Ni(n,2n)57Ni, 67Zn(n,p)67Cu, 92Mo(n,p)92mNb, 93Nb(n,γ)94Nb, 113In(n,n')113mIn, 115In(n,γ) 116mIn, and 169Tm(n,3n)167Tm Reactions. Progress Report on Research Contract No 16242

    International Nuclear Information System (INIS)

    Zolotarev, K.I.; Zolotarev, P.K.

    2013-12-01

    Cross section data for the 54 Fe(n,p) 54 Mn, 58 Ni(n,2n) 57 Ni, 67 Zn(n,p) 67 Cu, 92 Mo(n,p) 92m Nb, 93 Nb(n,γ) 94 Nb, 113 In(n,n') 113m In, 115 In(n,γ) 116m In, 169 Tm(n,3n) 167 Tm reactions are needed to solve a wide spectrum of scientific and technical tasks. Activation detectors based on these reactions may be used in the field of reactor dosimetry. Furthermore, the 54 Fe(n,p) 54 Mn reaction is often used in experimental nuclear physics as a monitor reaction for measurements of unknown cross sections by means of the activation method over the neutron energy range from 5 to 15 MeV. The 93 Nb(n,γ) 94 Nb reaction is also very promising for using in retrospective neutron dosimetry for determination of total neutron fluence during a campaign of a reactor. In the existing version of the International Reactor Dosimetry File and the new extended version named as IRDFF data for excitation functions of 67 Zn(n,p) 67 Cu, 92 Mo(n,p) 92m Nb, 113 In(n,n') 113m In, and 169 Tm(n,3n) 167 Tm reactions are absent. Data for these reactions are also absent in the JENDL/D-99 dosimetry file. Excitation functions of 67 Zn(n,p) 67 Cu and 169 Tm(n,3n) 167 Tm are presented in the TENDL-2012, EAF-2010, JENDL-4.0, JEFF-3.1/A, MENDL-2 libraries. Cross section data for the 67 Zn(n,p) 67 Cu reaction up to 20 MeV are given also in the JENDL/HE-2007 library. Excitation functions of the 92 Mo(n,p) 92m Nb and 113 In(n,n') 113m In reactions are evaluated in the EAF-2010 and JEFF-3.1/A libraries. Cross section data for the 113 In(n,n') 113m In reaction are given also in the TENDL-2010 library. It is necessary to note that neutron data in the JEFF-3.1/A and JENDL-4.0 libraries were evaluated up to 20 MeV. Neutron data in the TENDL-2012, EAF-2010, MENDL-2 and TENDL-2010 libraries had been evaluated up to 30 MeV, 60 MeV, 100 MeV and 200 MeV, respectively. Neutron cross sections in the MENDL-2, TENDL-2010 and TENDL-2012 libraries had been obtained on the basis of pure theoretical model calculations

  20. Release of Fission Products from UC-ZrC Fuel Inserts; Degagement des produits de fission liberes dans des noyaux combustibles UC-ZrC; Vydelenie produktov deleniya iz topliv UC - ZrC; Liberacion de productos de fision por pastillas de combustible de UC-ZrC

    Energy Technology Data Exchange (ETDEWEB)

    Barth, F.; Von der Decken, C. B.; Schifferstein, K. [Brown Boveri/Krupp Reaktorbau G.M.B.H., Duesseldorf (Germany); Clauss, A.; Reichel, H.; Rygaert, J.; Ruston, W. R. [Societe d' Etudes de Recherches et d' Applications pour l' Industrie (S.E.R.A.I.), Brussels (Belgium)

    1963-11-15

    hallaron grandes diferencias en las energias de activacion determinadas en distintos tipos de pastillas, aunque algunas veces los valores D/r{sub 0}{sup 2} paragraph diferian en cuatro ordenes de magnitud para una misma temperatura de la muestra. Despues de la irradiacion, se determinaron las actividades de los isotopos {sup 131}I, {sup 85}Sr, {sup 140}Ba y {sup 141}Ce en el grafito de las capsulas. Exceptuando el {sup 131}I, las actividades resultaron superiores a las previstas para un desprendimiento debido solamente a retroceso. Los valores correspondientes al {sup 89}Sr, {sup 140}Ba y {sup 141}Ce son damasiado altos para que puedan atribuirse a una difusion de loe respectivos gases nobles precursores. Se supone que los isotopos medidos, o sus precursores distintos de los gases nobles se desprendieron por difusion. (author) [Russian] Provedeno issledovanie vo vremya oblucheniya v petle vydeleniya produktov deleniya ieh tabletok, imeyushchikh priblizitel'nyj sostav UC + 20 ZrC. Tsel' - proverka vozmozhnosti ispol'zovaniya podobnykh tabletok v kachestve topliva v sfericheskikh teplovydelyayushchikh ehlementakh vysokotemperaturnogo reaktora, postroennogo v Yulikhe ''Obshchestvom stroitel'stva reaktorov Braun Boveri/Krupp''. Ispytaniyu podvergalis' svobodnye tabletki i tabletki, vstavlennye v grafitovye kapsuly. Nekotorye iz tabletok imeli pogranichnuyu zonu ieh chistogo karbida tsirkoniya, tolshchinoj 1 - 2 mm. Obraztsy pomeshchalis' v pechi ehlektricheskogo soprotivleniya, dayushchie maksimal'nuyu temperaturu 1600{sup o}C. Nejtronnyj potok vo vremya oblucheniya sostavlyal 3 - 4 x 10{sup 10} n/cm{sup 2} -sek. Petlya pozvolyala izmerit' vydelenie izotopov inertnykh gazov Kr{sup 85m}, Kr{sup 87}, Kr{sup 88},Xe{sup 133} i Xe{sup 135} vo vremya oblucheniya, i kosvennoe opredelenie I{sup 133} i I{sup 135} posle vyklyucheniya reaktora. Minimum vydeleniya I{sup 131}, Sr{sup 88}, Ba{sup 141} i Ce{sup 141} byl opredelen radiokhimicheskim metodom posle izvlecheniya obraztsa iz

  1. Some factors influencing the absorption, retention and elimination of ruthenium; Facteurs agissant sur l'absorption, la retention et l'elimination du ruthenium; Nekotorye faktory, vliyakshchie na vsasyvanie, zaderzhku i vydelenie ruteniya; Factores que influyen sobre la absorcion, retencion y eliminacion de rutenio

    Energy Technology Data Exchange (ETDEWEB)

    Bruce, R. S. [Radiobiological Research Council, Medical Research Council, Harwell (United Kingdom)

    1963-02-15

    syvorotki. Zaderzhka ruteniya v drugikh tkanyakh takzhe mozhet opredelyat'sya skorost'yu katabolizma belkov. Poskol'ku pri reaktsii ruteniya s belkami obrazuyutsya ustojchivye kompleksy, trudno najti kakoelibo aek and rgtgennoe lechenie dlya snizheniya zaderzhki. Kompleksoobrazukhntsie veshchestva EDTA, DTRA i TTJA ne vliyayut na raspredelenie ili vydelenie ruteniya, vvedennogo krysam vnutrivenno. (author)

  2. Excretion of radium in relation to dietary intake; Excretion de radium en fonction de l'ingestion alimentaire; Vydelenie radiya v zavisimosti ot priema ego s pishchej; Excrecion de radio en relacion con su absorcion con los alimentos y el agua

    Energy Technology Data Exchange (ETDEWEB)

    Turner, R. C. [Institute of Cancer Research, Royal Cancer Hospital, London (United Kingdom)

    1963-02-15

    Comprehensive measurements of the Ra{sup 226} contents of more than 200 common foods and 100 of the principal supplies of drinking water in Great Britain have been used to compare the mean intakes of radium per person from these sources, in a number of occupational groups as well as among the populations of various region; of the country. In spite of the wide range of activities present in foods, the mean intakes show little variation among the groups, the values lying between 2 and 3 pc per person per day. The drinking waters in Britain have radium contents differing by factors of up to 250 to 1, but in the majority of cases the absolute levels are so low relative to those present in the staple foods that the mean intakes from water represent only 5 to 6% of the mean total amounts of radium ingested by each individual. Only in one exceptional area of the country, representing less than 1% of the total population, is it possible for the daily intakes from water to exceed those from food. Measurements of faecal excretion resulting from the normal dietary intake have shown that in the case of young adults, the average level of Ra{sup 226} excreted in this way is 2 to 2.5 pc/d. This figure agrees with the estimates of the mean daily intakes. Human metabolic studies have shown that the large majority of each day's dietary intake of radium is excreted within 24 to 48 h, but attempts to assess the fractional retention in adults have given variable results. Measurements of the daily intakes and faecal excretions of a young child, over a period of 33 d, indicate that the retention of radium during periods of active bone growth may be as high as 10% or even more. (author) [French] En Grande-Bretagne, on a mesure la teneur en {sup 226}Ra de plus de 200 aliments courants et d'une centaine des principales reserves d'eau potable en vue de comparer les taux moyens d'ingestion du radium en provenance de ces sources, tant pour un certain nombre de groupes professionnels que pour la population de certaines regions du pays. En depit d'activites tres diverses selon les aliments, les taux moyens d'ingestion different fort peu d'un groupe a l'autre, les valeurs se situant entre 2 et 3 pps par personne et par jour. Les teneurs en radium des diverses eaux potables en Grande-Bretagne accusent des differences allant jusqu'a 250 : 1. Toutefois, dans la plupart des cas, les valeurs absolues sont tellem ent faibles par rapport a celles qu'on releve dans les aliments de base que le taux moyen d'ingestion avec l'eau represente 5 a 6% seulement de la dose totale de radium ingeree par chaque personne. Ce n'est que dans une seule region du pays, qui compte moins de 1% de l'ensemble de la population, que l'ingestion journaliere avec l'eau pourrait exceder l'ingestion avec les aliments. En mesurant l'excretion fecale provenant de l'ingestion alimentaire normale, on a constate que pour les jeunes adultes la dose moyenne de {sup 226}Ra ainsi excretee est de 2 a 2,5 ppc par jour. Ce chiffre est en bon accord avec les estimations de l'ingestion journaliere moyenne. Les etudes du metabolisme de l 'organisme humain montrent que la plus grande partie du radium ingere journellement avec les denrees alimentaires est excretee dans les 24 a 48 heures. Cependant, les tentatives faites,pour evaluer la retention fractionnelle chez les adultes ont donne des resultats variables. Les mesures des taux journaliers d'ingestion et d'excretion fecale chez un jeune enfant, poursuivies pendant une duree de 33 jours, montrent que la retention de radium pendant les periodes de croissance osseuse active peut atteindre 10% ou davantage. (author) [Spanish] El autor utilizo los resultados de amplias determinaciones del contenido de {sup 226}Ra en mas de 200 productos alimenticios de uso corriente y en 100 muestras de distintas aguas potables britanicas para comparar la absorcion individual media de radio de dichos origenes, en una serie de grupos profesionales, asi como entre las poblaciones de varias regiones del pafs. A pesar de la extensa gama de las actividades presentes en los alimentos, las cantidades medias absorbidas varian escasamente de un grupo a otro, oscilando sus valores entre 2 y 3 pe por persona y por dia. El contenido de radio en las aguas potables de Gran Bretana puede variar en la relacion de 1: 250 de un lugar a otro, si bien en la mayoria de los casos los valores absolutos son tan bajos en comparacion con los determinados en los productos alimenticios de mayor consumo que las cantidades medias absorbidas procedentes del agua representan apenas el 5 o 6% de las cantidades medias totales de radio ingeridas por cada individuo. Solamente en una region excepcional del pafs, a la que corresponde menos del 1% de la poblacion total, llegan las cantidades absorbidas diariamente procedentes del agua a superar a las derivadas de los productos alimenticios. Los analisis de las materias fecales de sujetos sometidos a un regimen alimenticio normal han demostrado que, en el caso de los adultos jovenes, las cantidades medias de {sup 226} Ra excretadas por esa via corresponden a una cantidad de 2 a 2,5 pe por dia. Estos valores numericos coinciden con las cantidades medias absorbidas diariamente. Los estudios del metabolismo humano han demostrado que la mayor parte del radio absorbido diariamente con los alimentos se excreta dentro de las 24 o 48 horas, pero los intentos de evaluar la retencion fraccionaria en los adultos ha arrojado resultados variables. En el caso de un nino de corta edad, las determinaciones de las cantidades absorbidas diariamente y de las excretadas con las heces, en un periodo de 33 dias, indican que la retencion del radio durante los periodos de crecimiento activo del esqueleto puede llegar al 10% o aun mas. (author) [Russian] Ischerpyvayushchie izmereniya soderzhaniya radiya-226 v bolee chem 200 vidakh obychnykh produktov pitaniya i 100 glavnykh istochnikakh pit'evoj vody v Velikobritanii byli ispol'zovany dlya sravneniya srednej velichiny potrebleniya radiya odnim chelovekom iz ehtikh istochnikov sredi ryada professional'nykh grupp, ravno kak sredi grupp naseleniya razlichnykh rajonov strany. Nesmotrya na shirokij interval velichin aktivnosti produktov pitaniya, srednie velichiny priema malo otlichayutsya drug ot druga u raznykh grupp, pri ehtom oni koleblyutsya mezhdu 2 i 3 mmkkyuri na cheloveka v den'. Soderkhanie radiya v pit'evoj vode v Anglii menyaetsya v diapazone koehffitsientov ot 250 do 1, no v bol'shinstve sluchaev absolyutnye urovni nastol'ko nizki po sravneniyu s urovnem v osnovnykh produktakh pitaniya, chto srednie velichiny potrebleniya radiya s vodoj sostavlyayut lish' 5 - 6% ot srednikh obshchikh kolichestv radiya, pogloshchaemogo kazhdym individuumom. Lish' v odnom rajone strany, v kotorom -prozhivaet men'she odnogo protsenta vsego naseleniya, dnevnoe potreblenie radiya s vodoj prevyshaet potreblenie ego s pishchej. Izmereniya vydelenij s isprazhneniyami v rezul'tate normal'nogo priema pishchi pokazyvaet, chto u vzroslykh molodykh lyudej srednee kolichestvo radiya-226, vydelyaemogo takim putem, sostavlyaet 2-2,5 mmkkyuri v den'. Ehta tsifra soglasuetsya s vychislennymi dannymi srednego dnevnogo priema. Issledovaniya metabolizma u lyudej pokazyvayut, chto bol'shaya chast' sutochnogo kolichestva radiya, prinyatogo s pishchej, vydelyaetsya v techenie 24 - 48 chasov, no popytki opredelit' fraktsionnoe uderzhanie radiya u vzroslykh privodyat k neodinakovym rezul'tatam. Izmereniya velichin dnevnogo priema i vydeleniya s isprazhneniyami u malen'kikh detej v techenie 33 dnej ukazyvayut na to, chto uderzhanie radiya v periody aktivnogo rosta kostej mozhet sostavlyat' do 10% ili bolee ot obshchego kolichestva radiya, prinyatogo vnutr'. (author)

  3. Copper-67 labeled porphyrin localization in inflamed tissues

    International Nuclear Information System (INIS)

    Cole, D.A.; Mercer-Smith, J.A.; Norman, J.K.; Bullington, K.P.; Roberts, J.C.; Lavellee, D.K.

    1989-01-01

    A series of experiments compared the uptake of 5,10,15,20-tetrakis(4-carboxyphenyl) porphinato [ 67 Cu] copper(II), 67 CuTCPP, by the lymph nodes of inflamed and two sets or control rats. The results demonstrate that 67 CuTCPP localizes in greater concentration in inflamed lymph nodes than in noninflamed control lymph nodes. This enhanced uptake of 67 CuTCPP by inflamed lymph nodes was 3.6 times greater than was the uptake by control lymph nodes. A time course study demonstrated that the uptake of 67 CuTCPP inflamed lymph nodes reached the maximum level by 24 hours post-injection of 67 CuTCPP and remained constant throughout the 96 hours examined. It was also found that the uptake of 67 CuTCPP by inflamed lymph nodes was not exclusively dependent upon an increase in the weight of inflamed lymph nodes. These studies show that 67 CuTCPP has potential as a lymphoscintigraphy agent. 29 refs., 5 figs., 1 tab

  4. Towards tumour targeting with copper-radiolabelled macrocycle-antibody conjugates

    International Nuclear Information System (INIS)

    Morphy, J.R.; Parker, David; Kataky, Ritu

    1989-01-01

    Tetraaza-macrocycles covalently attached to a monoclonal antibody may be efficiently radiolabelled with 64 Cu or 67 Cu at pH4, minimising non-specific binding to the protein, giving a kinetically stable conjugate in vivo. (author)

  5. Effect of fructose or starch on copper-67 absorption and excretion by the rat

    International Nuclear Information System (INIS)

    Fields, M.; Holbrook, J.; Scholfield, D.; Smith, J.C. Jr.; Reiser, S.

    1986-01-01

    Studies with 67 Cu were conducted with copper-deficient or supplemented rats fed fructose or starch in an effort to investigate the effects of different dietary carbohydrates and inadequate copper intake on the absorption, tissue distribution and excretion of copper. After being fed their diets for 5 wk, they were killed at 8, 24, 48 and 96 h following the intubation of their respective copper-supplemented diets extrinsically labeled with 67 Cu. Only at 48 and 96 h following the intubation of 67 Cu, the gastrointestinal (GI) contents of rats fed the copper-deficient fructose diet exhibited higher radioactivity than rats fed the copper-deficient starch diet. Although not always significant, this apparent retention of copper in GI contents was accompanied by decreased whole-body radioactivity and depressed urinary excretion. The cumulative excretion of 67 Cu via feces over the 96-h period of collection was similar for both groups of copper-deficient rats, regardless of whether the dietary carbohydrate was fructose or starch. The data suggest that the more severe copper deficiency is related to the sustained higher level of radioactivity in the GI contents. This increased retention of 67 Cu in GI contents suggests impaired absorption of copper

  6. Tissue distribution and excretion of copper-67 intraperitoneally administered to rats fed fructose or starch

    International Nuclear Information System (INIS)

    Holbrook, J.; Fields, M.; Smith, J.C. Jr.; Reiser, S.

    1986-01-01

    It has been suggested that impaired gut absorption of copper is the cause of the exacerbated copper deficiency signs in rats fed fructose when compared to rats fed starch. The present study was designed to examine how rats fed fructose or starch diets, either copper-deficient or supplemented, distributed and excreted 67 Cu when the isotope was administered i.p. Intraperitoneal administration was chosen in an effort to circumvent primary gut absorption as a factor in the metabolism of 67 Cu. After 7 wk of dietary treatment, rats received an i.p. injection of 67 Cu and were placed in metabolic cages for 4 d. Regardless of dietary carbohydrate, copper-deficient rats retained similar levels of radioactivity in various tissues and excreted similar amounts of 67 Cu in feces and urine. This similarity in copper metabolism in copper-deficient rats fed either fructose or starch when the gut was circumvented for isotope administration suggests that the gut could be responsible, at least in part, for the exacerbated signs associated with the copper deficiency in rats fed fructose. The possibility is discussed that alterations in metabolism may increase the requirement for copper when fructose is the main dietary carbohydrate

  7. Towards tumour targeting with copper-radiolabelled macrocycle-antibody conjugates

    Energy Technology Data Exchange (ETDEWEB)

    Morphy, J.R.; Parker, David; Kataky, Ritu; Harrison, Alice; Walker, Carole; Eaton, M.A.W.; Millican, Andrew; Phipps, Alison

    1989-06-15

    Tetraaza-macrocycles covalently attached to a monoclonal antibody may be efficiently radiolabelled with /sup 64/Cu or /sup 67/Cu at pH4, minimising non-specific binding to the protein, giving a kinetically stable conjugate in vivo. (author).

  8. Basic Research and Feasibility Study of Radioisotope Production using 100 MeV Proton Beam

    International Nuclear Information System (INIS)

    Yoo, K. H.; Yoon, K. S.; Cho, W. J.; Park, S. I.; Han, H. S.; Yang, S. D.; Jeon, K. S.; Kim, J. H.; Yang, T. K.

    2010-04-01

    Results of the project are various nuclei, such as 82 Rb, 68 Ga, 67 Cu, 22 Na and so on, can be produced by irradiating 100 MeV proton beam, by irradiating proton beam to the nat Ga target, the 68 Ge, mother nucleus of positron emitting 68 Ga, is produced based on the nat Ga(p,x) 68 Ge reaction, the target system for the high-energy of proton beam can produce more than 2 species of radioisotope at the same time by employing tandem targets, 68 Ge/ 68 Ga generator, 82 Sr(25.34d)/ 82 Rb generator - 67 Cu production method, 70 Zn electroplating technology based on the electrochemistry, the container, whose weight is about 3 ton, is made by depleted uranium and because of the unstable situation for the supply and demand of reactor produced radioisotope, the need for the cyclotron produced radioisotopes is dramatically increased all over the world.

  9. Effects of chronic copper exposure during early life in rhesus monkeys.

    Science.gov (United States)

    Araya, Magdalena; Kelleher, Shannon L; Arredondo, Miguel A; Sierralta, Walter; Vial, María Teresa; Uauy, Ricardo; Lönnerdal, Bo

    2005-05-01

    Whether infants regulate copper absorption and the potential effects of excess copper in early life remain poorly defined. The objective of the study was to assess copper retention, liver copper content, and liver function in infant rhesus monkeys fed infant formula containing 6.6 mg Cu/L. From birth to 5 mo of age, infant rhesus monkeys were fed formula that was supplemented with copper (0.6 mg Cu/L; n = 5) or not supplemented (n = 4). In all animals, weight and crown-rump length (by anthropometry), hemoglobin, hematocrit, plasma ceruloplasmin activity, and zinc and copper concentrations were measured monthly (birth to 6 mo) and at 8 and 12 mo. When the animals were 1, 5, and 8 mo old, liver copper and metallothionein concentrations, liver histology (by light and electron microscopy), and the number of Kupffer cells were assessed, and 67Cu retention was measured. Liver function was assessed by measurement of plasma alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, and alkaline phosphatase activities and protein, albumin, bilirubin, and blood urea nitrogen concentrations. 67Cu retention was 19.2% and 10.9% after 1 and 5 mo of copper treatment, respectively, compared with approximately 75% in controls at age 2 mo. At age 8 mo, 67Cu retention was 22.9% in copper-treated animals and 31.5% in controls. Liver histology remained normal by light microscopy, with mild ultrastructural signs of cell damage at 5 mo. Liver copper concentration was 4711, 1139, and 498 microg/g dry tissue at 1, 5, and 8 mo, respectively, in copper-treated animals and 250 microg/g at 2 mo in controls. Measurements could not be completed in all animals. No clinical evidence of copper toxicity was observed. Copper absorption was down-regulated; increases in liver copper content at ages 1 and 5 mo did not result in histologic damage. Ultrastructural changes at age 5 mo could signal early cellular damage.

  10. Tumour targeting with monovalent fragments of anti-neuroblastoma antibody chCE7

    International Nuclear Information System (INIS)

    Carrel, F.; Novak-Hofer, I.; Ruch, C.; Zimmermann, K.; Amstutz, H.

    1997-01-01

    The in vitro and in vivo behaviour of the monovalent single chain (scFv) and Fab-fragments derived from anti-neuroblastoma antibody chCE7 is reported. When comparing tumour uptake and -retention of radioactivity of 67 Cu-labelled monovalent chCE7 with divalent chCE7 F(ab') 2 the advantage of the radiocopper label over the radioiodine label was more pronounced with the divalent (internalising) F(ab') 2 fragments. (author) 1 fig., 1 ref

  11. Medical isotope development and supply opportunities in the 21st century

    International Nuclear Information System (INIS)

    Troyer, G.L.; Schenter, R.E.

    2009-01-01

    Research in extending medical isotopes for the diagnosis and treatment of numerous health maladies is hampered by outages and upsets in major supply sources. Investigations in cures for brain cancer ( 211 At), HIV/AIDS virus ( 213 Bi), and even bacterial vectors are either in reduced progress mode or have been cancelled until isotopes become available. Examples of several key radioactive medical isotopes include 99m Tc for diagnostics, 131 I for non-Hodgkin's Lymphoma and thyroid cancer, 225 Ac for acute myelogenous leukemia, and 67 Cu for lymphoma cancer. Possibilities for developing commercially viable sources using compact accelerators and next generation research and production reactors are discussed. (author)

  12. Isotope dilution measurement of copper absorption and excretion in rats fed different carbohydrates

    International Nuclear Information System (INIS)

    Johnson, P.E.; Bowman, T.D.

    1986-01-01

    An isotope dilution method using 67 Cu was developed to measure true absorption (A) and endogenous excretion (EE) of Cu in rats. Specific activity (SA) of injected 67 Cu was least variable in 7 tissues on days 6-8 after injection. SA of feces compared to tissues was used to calculate EE and A. This method was used to study Cu metabolism in rats fed 5 ppm or 0.4 ppm Cu and diets containing fructose (FR), glucose (GL), sucrose (SU), or cornstarch (CS). In rats fed 5 ppm Cu, the A, EE, and balance (B) were greatest for CS animals. There were no differences in A, B, or EE between FR and SU rats (p > .05). Rats fed GL had B and A lower than other groups (p .05). Liver Cu did not differ among groups fed 0.4 ppm Cu. Kidney Cu was higher ( p .05) compared to rats fed GL and 5 ppm Cu. EE was significantly lower in all groups on 0.4 ppm Cu than 5 ppm Cu. EE was 1 μg Cu/d on the 0.4 ppm Cu diet

  13. Dosimetric model for antibody targeted radionuclide therapy of tumor cells in cerebrospinal fluid

    International Nuclear Information System (INIS)

    Millar, W.T.; Barrett, A.

    1990-01-01

    Although encouraging results have been obtained using systemic radioimmunotherapy in the treatment of cancer, it is likely that regional applications may prove more effective. One such strategy is the treatment of central nervous system leukemia in children by intrathecal instillation of targeting or nontargeting beta particle emitting radionuclide carriers. The beta particle dosimetry of the spine is assessed, assuming that the spinal cord and the cerebrospinal fluid compartment can be adequately represented by a cylindrical annulus. The radionuclides investigated were 90 Y, 131 I, 67 Cu, and 199 Au. It is shown that the radiation dose to the cord can be significantly reduced using short range beta particle emitters and that there is little advantage in using targeting carriers with these radionuclides. 199 Au and 67 Cu also have the advantage of having a suitable gamma emission for imaging, permitting pretherapy imaging and dosimetric calculations to be undertaken prior to therapy. If these methods prove successful, it may be possible to replace the external beam component used in the treatment of central nervous system leukemia in children by intrathecal radionuclide therapy, thus reducing or avoiding side effects such as growth and intellectual impairment

  14. Effect of microstructure on the mechanical properties of as-cast Ti-Nb-Al-Cu-Ni alloys for biomedical application.

    Science.gov (United States)

    Okulov, I V; Pauly, S; Kühn, U; Gargarella, P; Marr, T; Freudenberger, J; Schultz, L; Scharnweber, J; Oertel, C-G; Skrotzki, W; Eckert, J

    2013-12-01

    The correlation between the microstructure and mechanical behavior during tensile loading of Ti68.8Nb13.6Al6.5Cu6Ni5.1 and Ti71.8Nb14.1Al6.7Cu4Ni3.4 alloys was investigated. The present alloys were prepared by the non-equilibrium processing applying relatively high cooling rates. The microstructure consists of a dendritic bcc β-Ti solid solution and fine intermetallic precipitates in the interdendritic region. The volume fraction of the intermetallic phases decreases significantly with slightly decreasing the Cu and Ni content. Consequently, the fracture mechanism in tension changes from cleavage to shear. This in turn strongly enhances the ductility of the alloy and as a result Ti71.8Nb14.1Al6.7Cu4Ni3.4 demonstrates a significant tensile ductility of about 14% combined with the high yield strength of above 820 MPa already in the as-cast state. The results demonstrate that the control of precipitates can significantly enhance the ductility and yet maintaining the high strength and the low Young's modulus of these alloys. The achieved high bio performance (ratio of strength to Young's modulus) is comparable (or even superior) with that of the recently developed Ti-based biomedical alloys. © 2013.

  15. Evaluation of radioiodinated and radiocopper labeled monovalent fragments of monoclonal antibody chCE7 for targeting of neuroblastoma

    International Nuclear Information System (INIS)

    Carrel, Francois; Amstutz, Hanspeter; Novak-Hofer, Ilse; Schubiger, P. August

    1997-01-01

    Monovalent fragments of antineuroblastoma antibody mAb chCE7 were evaluated for their in vitro and in vivo tumor cell binding properties. Single chain fragments were constructed from the variable region genes cloned from hybridoma cells, expressed in E.coli and purified by metal chelate affinity chromatography. Radioiodinated CE7-scFv fragments were found to bind with high affinity (K d ∼10 -9 M) to target cells in vitro but formed aggregates at 37 deg. C, and bound to serum proteins in vitro and in vivo. Circular Dichroism spectra revealed the protein to be in a conformationally altered form and no permanent 'refolding' could be achieved. In contrast, chCE7-Fab fragments were found to bind to target tumor cells with similar affinity than the parent mAb chCE7 (K d ∼10 -10 M), showed no tendency to aggregate and were stable in serum both in vitro and in vivo. Kinetics of association and dissociation of radioiodinated scFv and Fab fragments were found to be rapid. Radioiodination with the Iodogen method led to impaired immunoreactivity which was found to further increase the off- rates of radioiodinated fragments from tumor cells. Radioiodination with the Bolton-Hunter reagent as well as labeling of chCE7-Fab fragments with 67 Cu via the macrocyclic CPTA ligand led to fully immunoreactive Fab fragments. Radioiodinated and radiocopper labeled monovalent CE7 fragments did not internalize into target tumor cells as the parent mAb and its F(ab') 2 fragment. A comparison of the biodistribution in tumor bearing nude mice of the radiocopper labeled monovalent, non internalizing Fab fragments with the internalizing divalent F(ab') 2 fragments showed in both cases high levels of radioactivity in the kidneys. Concerning tumor uptake, radioactivity from both internalizing and non internalizing fragments remained associated with tumor tissue for longer times than in case of the corresponding radioiodinated fragments. When compared with the radioiodinated forms, tumor uptake

  16. [Studies of biologic activation associated with molecular receptor increase and tumor response in ChL6/L6 protocol patients; Studies in phantoms; Quantitative SPECT; Preclinical studies; and Clinical studies]. DOE annual report, 1994-95

    International Nuclear Information System (INIS)

    DeNardo, S.J.

    1995-01-01

    The authors describe results which have not yet been published from their associated studies listed in the title. For the first, they discuss Lym-1 single chain genetically engineered molecules, analysis of molecular genetic coded messages to enhance tumor response, and human dosimetry and therapeutic human use radiopharmaceuticals. Studies in phantoms includes a discussion of planar image quantitation, counts coincidence correction, organ studies, tumor studies, and 90 Y quantitation with Bremsstrahlung imaging. The study on SPECT discusses attenuation correction and scatter correction. Preclinical studies investigated uptake of 90 Y-BrE-3 in mice using autoradiography. Clinical studies discuss image quantitation verses counts from biopsy samples, S factors for radiation dose calculation, 67 Cu imaging studies for lymphoma cancer, and 111 In MoAb imaging studies for breast cancer to predict 90 Y MoAb therapy

  17. Magnetic Moment of $^{59}$Cu

    CERN Multimedia

    2002-01-01

    Experiment IS358 uses the intense and pure beams of copper isotopes provided by the ISOLDE RILIS (resonance ionization laser ion source). The isotopes are implanted and oriented in the low temperature nuclear orientation set-up NICOLE. Magnetic moments are measured by $\\beta$-NMR. Copper (Z=29), with a single proton above the proton-magic nickel isotopes provides an ideal testground for precise shell model calculations of magnetic moments and their experimental verification. In the course of our experiments we already determined the magnetic moments of $^{67}$Ni, $^{67}$Cu, $^{68g}$Cu, $^{69}$Cu and $^{71}$Cu which provide important information on the magicity of the N=40 subshell closure. In 2001 we plan to conclude our systematic investigations by measuring the magnetic moment of the neutron-deficient isotope $^{59}$Cu. This will pave the way for a subsequent study of the magnetic moment of $^{57}$Cu with a complementary method.

  18. Feasibility study on medical isotope production using a compact neutron generator.

    Science.gov (United States)

    Leung, Ka-Ngo; Leung, James K; Melville, Graeme

    2018-07-01

    Compact neutron generators can provide high flux of neutrons with energies ranging from thermal (0.025 eV) to 14 MeV. Recent measurements demonstrated high neutron yields from the D- 7 Li fusion reaction at an interaction energy of 500 keV. Using the D- 7 Li reaction and applying new advancements in high flux neutron generator technology along with the commercial availability of high voltage DC power supplies enables the production of useful quantities of radioisotopes for medical applications. Using the known neutron reaction cross-sections, it has been estimated that hundreds-to-thousands MBq (or tens-to-hundreds mCi) of 99 Mo, 225 Ac, 64 Cu and 67 Cu can be obtained from a compact high flux neutron generator. Copyright © 2018 Elsevier Ltd. All rights reserved.

  19. Contribution of radioisotopes in the diagnosis of lung tumours

    International Nuclear Information System (INIS)

    Raynaud, C.; Crouzel, M.

    1976-01-01

    197 Hg, a radioisotope of half life 65 h, injected as acetate builds up in malignant tumours and evolutive inflammatory lesions. In spite of a high proportion of false positives it can lead to a lung cancer diagnosis under well-defined circumstances such as: round lung images, X-ray tuberculosis images persisting after prolonged therapy, treated cancers where it can detect relapses before X-rays and in the difficult case of benign tumours. In man the uptake kinetics of carrier-free 67 Cu (half-life 58 h), injected as citrate, are apparently not the same in cancers as in evolutive inflammatory lesions. The false positive yield, through much lower than that observed with 197 Hg, is still too high in this preliminary study [fr

  20. Pair and single neutron transfer with Borromean 8He

    International Nuclear Information System (INIS)

    Lemasson, A.; Navin, A.; Rejmund, M.; Keeley, N.; Zelevinsky, V.; Bhattacharyya, S.; Shrivastava, A.; Bazin, D.; Beaumel, D.; Blumenfeld, Y.; Chatterjee, A.; Gupta, D.; France, G. de; Jacquot, B.; Labiche, M.; Lemmon, R.; Nanal, V.; Nyberg, J.; Pillay, R.G.; Raabe, R.

    2011-01-01

    Direct observation of the survival of 199 Au residues after 2n transfer in the 8 He+ 197 Au system and the absence of the corresponding 67 Cu in the 8 He+ 65 Cu system at various energies are reported. The measurements of the surprisingly large cross sections for 199 Au, coupled with the integral cross sections for the various Au residues, is used to obtain the first model-independent lower limits on the ratio of 2n to 1n transfer cross sections from 8 He to a heavy target. A comparison of the transfer cross sections for 6,8 He on these targets highlights the differences in the interactions of these Borromean nuclei. These measurements for the most neutron-rich nuclei on different targets highlight the need to probe the reaction mechanism with various targets and represent an experimental advance towards understanding specific features of pairing in the dynamics of dilute nuclear systems.

  1. Contribution of radioisotopes in the diagnosis of lung tumours

    Energy Technology Data Exchange (ETDEWEB)

    Raynaud, C; Crouzel, M [CEA, 91 - Orsay (France). Service Hospitalier Frederic Joliot

    1976-12-01

    Mercury-197, a radioisotope of half life 65 h, injected as acetate builds up in malignant tumours and evolutive inflammatory lesions. In spite of a high proportion of false positives it can lead to a lung cancer diagnosis under well-defined circumstances such as: round lung images, x-ray tuberculosis images persisting after prolonged therapy, treated cancers where it can detect relapses before X-rays and in the difficult case of benign tumours. In man the uptake kinetics of carrier-free /sup 67/Cu (half-life 58 h), injected as citrate, are apparently not the same in cancers as in evolutive inflammatory lesions. The false positive yield, through much lower than that observed with /sup 197/Hg, is still too high in this preliminary study.

  2. Radioimmunotherapy: Development of an effective approach

    International Nuclear Information System (INIS)

    DeNardo, S.J.

    1991-01-01

    We plan to extend our success in treating B cell malignancies with 131 I labeled Lym-1 by a major effort in therapy with 67 Cu Lym-1. Yttrium-90 labeled by a macrocycle, DOTA will be studied in patients as a continuation of the 111 In-BAD (DOTA) Lym-1 studies. Excellent images and pharmacokinetics of the 111 In-BAD(DOTA)-Lym-1 studies. Lymphomas and related diseases represent a special case for radioimmunotherapy because of their documented radiosensitivity and immunodeficiency, and thus offer a unique opportunity to conduct therapeutic feasibility studies in a responsive human model. Using marine and chimeric L6 and other MoAb to breast cancer, we have applied the strategies that were developed in taking Lym-1 antibody from the bench to the patient. We have examined a number of monoclonal antibodies for treatment of breast cancer and chose chimeric L6 for prototype studies because of certain characteristics. The chemistry of attachment of conjugates to antibodies and their impact on immunological targeting biological activities (cytotoxicity), metabolic fate, and therapeutic index will continue to be a major strength and function of this program. This grant has supported the conception, synthesis, and development of the first macrocylic, bifunctional chelating agent TETA (6-p-nitrobenzyl-1,4,8,11-tetraazatetradecane-N,N',N double-prime, N'double-prime-tetraacetic acid and its derivatives, including Lym-1-2IT-BAT), for use in Cu-67-based radioimmunodiagnosis and therapy. This work has led to the further development of several new macrocylic bifunctional chelating agents for copper, indium, yttrium and other metals. In addition, successful Cu-67 labelings of Lym-1-2IT-BAT for human radiopharmaceutical have shown patient pharmacokinetics of 67 Cu-BAT(TETA)-Lym-1 with promising therapeutic dosimetry

  3. Copper absorption and copper balance during consecutive periods for rats fed varying levels of dietary copper

    International Nuclear Information System (INIS)

    Stuart, M.A.; Johnson, P.E.

    1986-01-01

    Copper (Cu) balance and absorption were studied to determine the extent to which absorption is dependent on dietary Cu. Over 12 consecutive 5-d metabolic periods, Cu balance was determined for four groups of young growing rats (n = 8) fed modified AIN-76 diets having different levels of added Cu (2.5, 5.0, 10 or 20 micrograms/g). Among groups, mean body weights did not differ over time (P greater than 0.05). There were no significant differences among groups for liver, heart or plasma Cu. Rats in all groups were in positive Cu balance throughout the study. After consuming the experimental diets for 10 d, rats eating 10 or 20 micrograms Cu/g diet showed a more positive Cu balance than did rats in the other groups. This trend continued until d 60. For rats eating 20 micrograms Cu/g diet, balance varied significantly over time. Three test meals labeled with stable 65Cu were fed at d 10, 40 and 50, respectively. Apparent Cu absorption, as determined by fecal monitoring of 65Cu, did not change appreciably over time for rats eating 2.5 or 5.0 micrograms Cu/g diet. A test meal labeled with radioactive 67Cu was fed at d 40. For rats eating 2.5 micrograms Cu/g diet, apparent absorption was higher (31%) than that for all other groups (5.0, 23%; 10, 19%; 20, 16%; P less than 0.05). Absorption values determined by whole-body retention of 67Cu were similar to those determined by fecal monitoring of 65Cu

  4. Measurement cross sections for radioisotopes production

    International Nuclear Information System (INIS)

    Garrido, E.

    2011-01-01

    New radioactive isotopes for nuclear medicine can be produced using particle accelerators. This is one goal of Arronax, a high energy - 70 MeV - high intensity - 2*350 μA - cyclotron set up in Nantes. A priority list was established containing β - - 47 Sc, 67 Cu - β + - 44 Sc, 64 Cu, 82 Sr/ 82 Rb, 68 Ge/ 68 Ga - and α emitters - 211 At. Among these radioisotopes, the Scandium 47 and the Copper 67 have a strong interest in targeted therapy. The optimization of their productions required a good knowledge of their cross-sections but also of all the contaminants created during irradiation. We launched on Arronax a program to measure these production cross-sections using the Stacked-Foils' technique. It consists in irradiating several groups of foils - target, monitor and degrader foils - and in measuring the produced isotopes by γ-spectrometry. The monitor - nat Cu or nat Ni - is used to correct beam loss whereas degrader foils are used to lower beam energy. We chose to study the nat Ti(p,X) 47 Sc and 68 Zn(p,2p) 67 Cu reactions. Targets are respectively natural Titanium foil - bought from Goodfellow - and enriched Zinc 68 deposited on Silver. In the latter case, Zn targets were prepared in-house - electroplating of 68 Zn - and a chemical separation between Copper and Gallium isotopes has to be made before γ counting. Cross-section values for more than 40 different reactions cross-sections have been obtained from 18 MeV to 68 MeV. A comparison with the Talys code is systematically done. Several parameters of theoretical models have been studied and we found that is not possible to reproduce faithfully all the cross-sections with a given set of parameters. (author)

  5. The Effect of Chlorothiazide on Caesium-137 Excretion in Human Subjects; Effet de la Chiorothiazide sur l'Elimination du Cesium 137 chez l'Homme; 0412 041b 0414 ; Influencia de la Ciorotiazida sobre la Excrecion de Cesio en el Hombre

    Energy Technology Data Exchange (ETDEWEB)

    Harrison, Joan; McNeill, K. G. [Departments of Medicine and Physics, University of Toronto, ON (Canada)

    1964-11-15

    . Por mas que la clorotiazida incremento la excrecion de potasio hasta 1,5 veces con respecto a los valores de referencia, no se comprobo que tuviera ningun efecto apreciable sobre la excrecion de cesio ni que redujera la carga corporal del mismo. Todos los sujetos excretaron rapidamente una pequena fraccion de cesio (10 a 20%) con un perfodo biologico (T{sub b}) inferior aid. El resto fue excretado en proporcion'constante con un de 90 a 155 d. Mas del 70% del cesio se excreto diariamente por via renal. El T{sub b} del potasio se calculo tambien por la formula: T{sub bK} = Total body K/Urine K x 0,693 x 0,8 admitiendo que el 80%-del potasio total excretado lo sea por via renal. El T{sub b} del K fue de 35 a 42 d. La razon de discriminacion T{sub bCs}/T{sub bK} escilo entre 2,1 y 3,8. Estos resultados demuestran que el cesio y el potasio no se utilizan de manera intercambiable. El cesio es retenido con preferencia al potasio y las alteraciones de la renovacion del potasio no ejercen ninguna influencia sobre la del cesio. Los autores prosiguen actualmente sus estudios con el proposito de determinar el efectp del metabolismo basal sobre la excrecion de cesio y oportunamente daran los resultados a que lleguen. (author) [Russian] Cel'ju'raboty javljalos' opredelenie faktorov, vljajushhih na metabolizm cezija u zdorovyh ljudej,i, v chastnosti, opredelenie terapevticheskogo rezhima, vedushhego k umen'sheniju soderzhanija cezija v organizme. Poskol'ku cezij i kalij obladajut shodnymi himicheskimi svojstvami i oba raspolagajutsja vnutrikletochno, glavnym obrazom v myshcah, vpolne vozmozhno, chto hlortiazid, okazyvajushhij vyrazhennyj kalievyj diureticheskij jeffekt, mozhet uvelichivat' i vydelenie cezija. Chetvero obsleduemyh poluchili vnutr' odnokratno po 0,1 mkkjuri cezija-137. Dvoim iz nih davali hlortiazid po 2,0 g v den' v techenie 3 dnej cherez chas posle priema cezija. Priem hlortiazida povtorili cherez dve nedeli. Dvuh drugih obsleduemyh ispol'zovali v kachestve

  6. Paul Scherrer Institut Scientific Report 2001. Volume II: Life Sciences

    Energy Technology Data Exchange (ETDEWEB)

    Jaussi, R; Gschwend, B [eds.

    2002-03-01

    The IMR group investigated some new approaches to tumour therapy. Several candidate molecules for targeting the tumour vasculature have been identified and are being produced for in vivo studies in tumour-bearing mice. The liposome technology is well established in this group and the goal is to produce suitably tagged liposomes for delivering a variety of cytotoxic agents to tumours. The Centre for Radiopharmaceutical Science, a joint venture with the ETH Zurich and the University of Zurich, pursues a number of projects that should eventually lead to novel radiopharmaceuticals for tumour diagnosis and therapy. Functionally, these radioactive drugs consist of a tumour targeting part, a radionuclide and a linking moiety, which stably connects the two. Optimisation of the components and their combination in terms of in vitro and in vivo properties as well as the efficient large-scale production of promising candidates for eventual first clinical trials is a demanding task. The major emphasis is still on using antibodies, antibody derivatives or peptides as tumour targeting vehicles. In collaboration with the Queens Medical Centre Nottingham, the first patients were treated with a {sup 67}Cu labelled antibody targeting bladder carcinomas. When completed, these studies should give us important information on the usefulness of {sup 67}Cu as a therapeutic radionuclide. Neuropeptides such as neurotensin and bombesin are promising starting points for tumour targeting as their receptors are over expressed on certain tumour cells. Presently, the efforts concentrate on preparing for further clinical studies with neurotensin derivatives (diagnosis of pancreatic tumours using {sup 99m}Tc) and further improving the stability and pharmacological properties of bombesin derivatives. In both these projects the ultimate goal is to label the optimised compounds with {sup 186}Re, a therapeutic radionuclide that can be attached in the stable tricarbonyl form which is easily accessible by

  7. Production of Medical Isotopes with Electron Linacs

    Energy Technology Data Exchange (ETDEWEB)

    Rotsch, D A; Alford, K.; Bailey, J. L.; Bowers, D. L.; Brossard, T.; Brown, M. A.; Chemerisov, S. D.; Ehst, D.; Greene, J.; Gromov, R. G.; Grudzinski, J.J.; Hafenrichter, L.; Hebden, A. S.; Henning, W.; Heltemes, T. A.; Jerden, J.; Jonah, C. D.; Kalensky, M.; Krebs, J. F.; Makarashvili, V.; Micklich, B.; Nolen, J.; Quigley, K. J.; Schneider, J. F.; Smith, N. A.; Stepinski, D. C.; Sun, Z.; Tkac, P.; Vandegrift, G. F.; Virgo, M J; Wesolowski, K. A.; Youker, A. J.

    2017-06-01

    Radioisotopes play important roles in numerous areas ranging from medical treatments to national security and basic research. Radionuclide production technology for medical applications has been pursued since the early 1900s both commercially and in nuclear science centers. Many medical isotopes are now in routine production and are used in day-to-day medical procedures. Despite these advancements, research is accelerating around the world to improve the existing production methodologies as well as to develop novel radionuclides for new medical appli-cations. Electron linear accelerators (linacs) represent a unique method for the production of radioisotopes. Even though the basic technology has been around for decades, only recently have electron linacs capable of producing photons with sufficient energy and flux for radioisotope production become available. Housed in Argonne Nation-al Laboratory’s Low Energy Accelerator Facility (LEAF) is a newly upgraded 55 MeV/25-kW electron linear ac-celerator, capable of producing a wide range of radioiso-topes. This talk will focus on the work being performed for the production of the medical isotopes 99Mo (99Mo/99mTc generator), 67Cu, and 47Sc.

  8. Fe and Cu in Si: Lattice sites and trapping at implantation-related defects

    International Nuclear Information System (INIS)

    Wahl, U.; Correia, J.G.; Rita, E.; Araujo, J.P.; Soares, J.C.

    2006-01-01

    We have used the emission channeling technique in order to study the lattice sites of radioactive 59 Fe and 67 Cu following 60 keV ion implantation into Si single crystals at fluences around 10 12 -10 14 cm -2 . We find that in the room temperature as-implanted state in high-resistivity Si both Fe and Cu occupy mainly lattice sites displaced around 0.05 nm (0.5 A) from substitutional positions. Both are released from these positions during annealing at temperatures between 300 deg. C and 600 deg. C. Fe is then found mainly on near-tetrahedral interstitial sites and further annealing causes it to be increasingly incorporated on ideal substitutional sites, on which it is stable to around 800 deg. C. We have strong indications that during annealing around 600 deg. C, along with the dominance of interstitial Fe, a redistribution towards the surface takes place, suggesting that the subsequent formation of ideal substitutional Fe may be related to the trapping of Fe at R p /2, half of its implanted depth. Possible R p /2 trapping might also have taken place in our Cu experiments but appears to be less efficient since Cu tended to escape to the bulk of the samples

  9. Beer improves copper metabolism and increases longevity in Cu-deficient rats

    International Nuclear Information System (INIS)

    Moore, R.J.; Klevay, L.M.

    1989-01-01

    Moderate consumption of alcoholic beverages decreases risk of death from ischemic heart disease (IHD). Evidence suggests that Cu-deficiency is important in the etiology and pathophysiology of IHD. The effect of beer (25 ng Cu/ml) drinking on the severity of Cu-deficiency was examined in weanling, male Sprague-Dawley rats fed a low Cu diet (0.84 μg Cu/g). Beer drinking increased median longevity to 204 or 299 d from 62 or 42 d respectively in rats drinking water in two experiments (15 rats/group). In experiment 3, a single dose of 67 Cu (3.3 μCi as chloride) was added to 1 g of feed and given to 12-h fasted rats 30 d after the start of the experiment. Whole body counting over 13 d showed apparent Cu absorption and t 1/2 (biological) were greater in Cu-deficient rats drinking beer than in similar rats drinking water. Plasma cholesterol was lower but hematocrit and liver Cu were higher in surviving rats drinking beer than in rats drinking water. Body weight was not affected by beer in any experiment. In experiment 4, a 4% aqueous ethanol solution had no effect on longevity of copper deficient rats. A non-alcohol component of beer alters Cu metabolism and mitigates the severity of nutritional Cu-deficiency in rats

  10. Cross section measurements for gallium in the neutron energy range of 13.5 to 14.8 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Luo, J. [Hexi Univ., Zhangye (China). School of Physics and Electromechanical Engineering; Liu, R.; Jiang, L. [Chinese Academy of Engineering Physics, Mianyang (China). Inst. of Nuclear Physics and Chemistry

    2012-07-01

    Cross sections for (n, 2n), (n, p) and (n, n'{alpha}) reactions have been measured on gallium isotopes at the neutron energies of 13.5-14.8 MeV using the activation technique. The monoenergetic neutron beam was produced via the {sup 3}H(d, n){sup 4}He reaction. The neutron fluences were determined using the monitor reaction {sup 27}Al(n, {alpha}){sup 24}Na. The activities induced in the reaction products were measured using high-resolution gamma-ray spectrometry. Data are reported for the following reactions: {sup 69}Ga(n, 2n){sup 68}Ga, {sup 71}Ga(n, 2n) {sup 70}Ga, {sup 69}Ga(n, p){sup 69m}Zn, {sup 71}Ga(n, p){sup 71m}Zn and {sup 71} Ga(n, n'{alpha}){sup 67}Cu. Nuclear model calculations using the code HFTT, which employs the Hauser-Feshbach (statistical model) and exciton model (precompound effects) formalisms, were undertaken to describe the formation of the reaction products. Results are discussed and compared with some corresponding values found in the literature, with some established systematics and with the evaluated data given in ENDF/B-VII.0, CENDL-3.1 and JENDL-4.0. (orig.)

  11. Search for a tensor component in the weak interaction Hamiltonian

    CERN Document Server

    Soti, Gergely

    The search for physics beyond the standard model can, besides in high-energy experiments such as the ones at the LHC accelerator, also be carried out at lower energies. Measurements of correlation coefficients in neutron and nuclear b decay constitute a reliable and model-independent method for such efforts. The topic of this thesis is the precision measurement of the beta asymmetry parameter A. It was measured in the decay of 67Cu, which proceeds via a pure Gamow-Teller b transition, thus its A parameter is sensitive to possible tensor type currents in the weak interaction. The experiment was performed at the NICOLE setup in ISOLDE (CERN), using the technique of low temperature nuclear orientation. The b particles were observed with custom made planar high purity germanium detectors operating at around 10 K. The beta asymmetry of 68Cu was measured on-line for normalization purposes. Geant4 simulations were used to gain control over systematic effects such as electron scattering on the particle detectors. As...

  12. Radiopharmaceutical labeling research

    International Nuclear Information System (INIS)

    Anon.

    1985-01-01

    The objective of this research is to develop methods of attaching radionuclides to monoclonal antibodies and antibody fragments for use in tumor imaging and internal radiation therapy. Monoclonal antibodies and their fragments are of interest because they enable the selective targeting of tumors. The labeled antibodies could be employed as carriers to transport radioisotopes to tumors, thus minimizing total-body radiation dose and radiation damage to normal tissue. Because the time required for labeled antibodies to find the tumor antigen and deliver the dose to the tumor is estimated to be about 1-3 days, radionuclides with a l- to 3-day half-life would be optimum for this purpose. Two of the radionuclides produced at LAMPF, 67 Cu and 77 Br, have the suitable half-life and nuclear-decay properties for use in tumor imaging or therapy with radiolabeled antibodies. These radionuclides and the efforts to prepare radiolabeled antibodies with them are described. We have used three different approaches to meet this objective of labeling antibodies: (1) labeling chelating agents with metal radionuclides, then conjugating the labeled chelating agents to antibodies; (2) conjugating activated chelating agents to antibodies, followed by metalation with metal radionuclides; and (3) radiobrominating small molecules that can be conjugated to antibodies

  13. Model-based predictions for nuclear excitation functions of neutron-induced reactions on 64,66−68Zn targets

    Directory of Open Access Journals (Sweden)

    M. Yiğit

    2017-08-01

    Full Text Available In this paper, nuclear data for cross sections of the 64Zn(n,2n63Zn, 64Zn(n,3n62Zn, 64Zn(n,p64Cu, 66Zn(n,2n65Zn, 66Zn(n,p66Cu, 67Zn(n,p67Cu, 68Zn(n,p68Cu, and 68Zn(n,α65Ni reactions were studied for neutron energies up to 40 MeV. In the nuclear model calculations, TALYS 1.6, ALICE/ASH, and EMPIRE 3.2 codes were used. Furthermore, the nuclear data for the (n,2n and (n,p reaction channels were also calculated using various cross-section systematics at energies around 14–15 MeV. The code calculations were analyzed and obtained using the different level densities in the exciton model and the geometry-dependent hybrid model. The results obtained from the excitation function calculations are discussed and compared with literature experimental data, ENDF/B-VII.1, and the TENDL-2015 evaluated data.

  14. Model-based predictions for nuclear excitation functions of neutron-induced reactions on {sup 64,} {sup 66-68}Zn targets

    Energy Technology Data Exchange (ETDEWEB)

    Yigit, M. [Faculty of Science and Arts, Dept. of Physics, Aksaray University, Aksaray (Turkmenistan); Kara, A. [Faculty of Engineering, Department of Energy Systems Engineering, Giresun University, Giresun (Turkmenistan)

    2017-08-15

    In this paper, nuclear data for cross sections of the {sup 64}Zn(n,2n){sup 63}Zn,{sup 64}Zn(n,3n){sup 62}Zn, {sup 64}Zn(n,p){sup 64}Cu, {sup 66}Zn(n,2n){sup 65}Zn, {sup 66}Zn(n,p){sup 66}Cu, {sup 67}Zn(n,p){sup 67}Cu, {sup 68}Zn(n,p){sup 68}Cu, and {sup 68}Zn(n,α){sup 65}Ni reactions were studied for neutron energies up to 40 MeV. In the nuclear model calculations, TALYS 1.6, ALICE/ASH, and EMPIRE 3.2 codes were used. Furthermore, the nuclear data for the (n,2n) and (n,p) reaction channels were also calculated using various cross-section systematics at energies around 14–15 MeV. The code calculations were analyzed and obtained using the different level densities in the exciton model and the geometry-dependent hybrid model. The results obtained from the excitation function calculations are discussed and compared with literature experimental data, ENDF/B-VII.1, and the TENDL-2015 evaluated data.

  15. Cyclotron production of {sup 64}Cu by deuteron irradiation of {sup 64}Zn

    Energy Technology Data Exchange (ETDEWEB)

    Abbas, K. [Institute for Health and Consumer Protection, Joint Research Centre, European Commission, TP 500, I-21020 Ispra (Vatican City State, Holy See,) (Italy)]. E-mail: kamel.abbas@jrc.it; Kozempel, J. [Institute for Health and Consumer Protection, Joint Research Centre, European Commission, TP 500, I-21020 Ispra (VA) (Italy); Charles University Prague, Faculty of Science, Department of Organic and Nuclear Chemistry, 128 43 Prague (Czech Republic); Bonardi, M. [LASA, Radiochemistry Laboratory, University and INFN, via F.lli Cervi 201, I-20090 Segrate (MI) (Italy); Groppi, F. [LASA, Radiochemistry Laboratory, University and INFN, via F.lli Cervi 201, I-20090 Segrate (MI) (Italy); Alfarano, A. [Institute for Health and Consumer Protection, Joint Research Centre, European Commission, TP 500, I-21020 Ispra (VA) (Italy); Holzwarth, U. [Institute for Health and Consumer Protection, Joint Research Centre, European Commission, TP 500, I-21020 Ispra (VA) (Italy); Simonelli, F. [Institute for Health and Consumer Protection, Joint Research Centre, European Commission, TP 500, I-21020 Ispra (VA) (Italy); Hofman, H. [Institute for Health and Consumer Protection, Joint Research Centre, European Commission, TP 500, I-21020 Ispra (VA) (Italy); Horstmann, W. [Institute for Health and Consumer Protection, Joint Research Centre, European Commission, TP 500, I-21020 Ispra (VA) (Italy); Menapace, E. [ENEA, Applied Physics Division, Bologna (Italy); Leseticky, L. [Charles University Prague, Faculty of Science, Department of Organic and Nuclear Chemistry, 128 43 Prague (Czech Republic); Gibson, N. [Institute for Health and Consumer Protection, Joint Research Centre, European Commission, TP 500, I-21020 Ispra (VA) (Italy)

    2006-09-15

    The short-lived (12.7 h half-life) {sup 64}Cu radioisotope is both a {beta} {sup +} and a {beta} {sup -} emitter. This property makes {sup 64}Cu a promising candidate for novel medical applications, since it can be used simultaneously for therapeutic application of radiolabelled biomolecules and for diagnosis with PET. Following previous work on {sup 64}Cu production by deuteron irradiation of natural zinc, we report here the production of this radioisotope by deuteron irradiation of enriched {sup 64}Zn. In addition, yields of other radioisotopes such as {sup 61}Cu, {sup 67}Cu, {sup 65}Zn, {sup 69m}Zn, {sup 66}Ga and {sup 67}Ga, which were co-produced in this process, were also measured. The evaporation code ALICE-91 and the transport code SRIM 2003 were used to determine the excitation functions and the stopping power, respectively. All the nuclear reactions yielding the above-mentioned radioisotopes were taken into account in the calculations both for the natural and enriched Zn targets. The experimental and calculated yields were shown to be in reasonable agreement. The work was carried out at the Scanditronix MC-40 Cyclotron of the Institute for Health and Consumer Protection of the Joint Research Centre of the European Commission (Ispra site, Italy). The irradiations were carried out with 19.5 MeV deuterons, the maximum deuteron energy obtainable with the MC-40 cyclotron.

  16. Applied Physics Research at the Idaho Accelerator Center

    International Nuclear Information System (INIS)

    Date, D. S.; Hunt, A. W.; Chouffani, K.; Wells, D. P.

    2011-01-01

    The Idaho Accelerator Center, founded in 1996 and based at Idaho State University, supports research, education, and high technology economic development in the United States. The research center currently has eight electron linear accelerators ranging in energy from 6 to 44 MeV with the latter linear accelerator capable of picosecond pulses, a 2 MeV positive-ion Van de Graaff, a 4 MV Nec tandem Pelletron, and a pulsed-power 8 k A, 10 MeV electron induction accelerator. Current research emphases include, accelerator physics research, accelerator based medical isotope production, active interrogation techniques for homeland security and nuclear nonproliferation applications, non destructive testing and materials science studies in support of industry as well as the development of advanced nuclear fuels, pure and applied radio-biology, and medical physics. This talk will highlight three of these areas including the production of the isotopes 99 Tc and 67 Cu for medical diagnostics and therapy, as well as two new technologies currently under development for nuclear safeguards and homeland security - namely laser Compton scattering and the polarized photofission of actinides

  17. Excitation function of (p,α) nuclear reaction on enriched {sup 67}Zn. Possibility of production of {sup 64}Cu at low energy cyclotron

    Energy Technology Data Exchange (ETDEWEB)

    Szelecsenyi, Ferenc; Kovacs, Zoltan [Hungarian Academy of Sciences, Debrecen (Hungary). Cyclotron Application Dept.; Nagatsu, Kotaro; Zhang, Ming-Rong; Suzuki, Kazutosi [National Institute of Radiological Sciences, Chiba (Japan). Molecular Imaging Center

    2014-09-01

    The potential for production of the medically relevant {sup 64}Cu has been investigated by proton irradiation of highly enriched {sup 67}Zn targets. The excitation function of the {sup 67}Zn(p,α){sup 64}Cu a nuclear reaction was measured by the stacked-foil technique up to 30 MeV. The prediction of the TALYS code was also compared to the measured cross section results. Based on the improved database of the {sup 67}Zn(p,α){sup 64}Cu reaction, thick target yield as a function of energy was also deduced. Production possibility of {sup 64}Cu is discussed in detail, employing different energy proton beams and with regards to the {sup 61}Cu and {sup 67}Cu contamination levels as a function of the target enrichment level. By using 1 μA beam intensity, 6.3505 h irradiation time and enriched {sup 67}Zn target ({sup 64}Zn ≤ 0.5%, {sup 66}Zn ≤ 9%, {sup 67}Zn ≥ 80%, {sup 68}Zn ≤ 10% and {sup 70}Zn ≤ 0.5%), the expected EOB (End Of bombardment) yields are 43.66, 88.80 and 156.14MBq/μA at 12, 15 and 18 MeV proton energies, respectively. Application time-frames were also deduced where the total radio-copper contamination level remains below 1%. (orig.)

  18. Urinary excretion of radiocopper in presymptomatic and symptomatic Wilson's disease, heterozygotes and controls: its significance in diagnosis and management

    Energy Technology Data Exchange (ETDEWEB)

    Gibbs, K; Hanka, R; Walshe, J M [Cambridge Univ. (UK). Clinical School

    1978-07-01

    Radiocopper (/sup 64/Cu, /sup 67/Cu), given intravenously, has been used to study the pattern of excretion of copper in patients with presymptomatic, symptomatic and treated Wilson's disease, together with heterozygotes for the Wilson's disease gene and a control group of patients with a variety of neurological lesions mimicking wilson's disease. The most important radiochemical findings were as follows. Heterozygotes excreted less of the injected copper than controls both under basal conditions and after penicillamine. Presymptomatic patients excreted less radiocopper than heterozygotes after penicillamine although the excretion during the basal 24 hour period was very much greater. Patients with symptomatic Wilson's disease had by far the highest excretion of radiocopper in all three time periods which fell after treatment, pro rata with time, as had been found for stable copper. These results were subjected to computer analysis. There was no overlap between the various groups with the exception of a single control subject who had combined pyramidal and extrapyramidal system degeneration of obscure aetiology. This patient was classified by the computer as 'heterozygote'. These findings lend further support to the hypothesis that the loss of a single gene for copper balance can be detected with a high degree of accuracy and also that presymptomatic patients can be selected from a sibship for prophylactic treatment without the risk of subjecting healthy heterozygotes to unnecessary and potentially hazardous longterm therapy.

  19. In-situ measurement of texture and elastic strains with HIPPO-CRATES

    International Nuclear Information System (INIS)

    Hartig, Ch.; Vogel, S.C.; Mecking, H.

    2006-01-01

    In this paper, the micromechanical interaction between constituents of a metallic material during elastic and plastic deformation are analyzed by comparing experimental results with modeling predictions. This comparison aims at determining the locally acting internal stresses, the spatial distribution of strains and the rules allowing deriving the macroscopic behavior of the material from the behavior of its microscopic constituents. We report the application of a new deformation apparatus CRATES, which allows measuring texture and crystal lattice spacings, and from these crystal lattice strains, using neutron diffraction. From the in-situ measured elastic lattice strains ε hkl the corresponding local stresses can be derived. The deformation apparatus allows uni-axial tensile or compressive deformation up to 100 kN and is specifically designed for use in the HIPPO neutron time-of-flight diffractometer. In this paper, we report initial results on an iron-copper model system (Fe100, Fe33Cu67, Fe67Cu33, vol.%) and commercial magnesium alloys (Mg-AZ31 and Mg-AZ80). Finite element calculations using a crystal-plastic constitutive law, allowing for shear and hardening of crystallographic slip-systems, were used for the interpretation of the measurements

  20. Optimization of copper, lead and cadmium biosorption onto newly isolated bacterium using a Box-Behnken design.

    Science.gov (United States)

    Choińska-Pulit, Anna; Sobolczyk-Bednarek, Justyna; Łaba, Wojciech

    2018-03-01

    Due to the progressive development of industrial and technological activities, heavy metal contamination is increasing each year and it poses a serious health and environmental risk. Microorganisms are capable of removing heavy metals from a contaminated environment. In this work, 51 microbial strains were isolated from heavy metal contaminated water and soil. The JAW1 strain, identified as Pseudomonas azotoformans, was selected and applied in bioremediation of the specific mixture of metals (Cd, Cu, and Pb) in an aqueous medium. The Box-Behnken design was used to optimize the biosorption process, with three factors: pH, initial metal concentration, concentration of the biosorbent. For the strain P. azotoformans JAW1, the optimal conditions were pH = 6.0, 25mg/L of each metal and 2g/L, following removal levels were achieved: Cd 44,67%; Cu 63,32%; Pb 78,23%. The possible interactions of cell-metal ions were evaluated using FT-IR analysis. The study indicated the presence of groups, which may be responsible for bonding of metal ions. The studies conducted on bioremediation mechanisms indicated that metal accumulation could occur on the cell surface (biosorption) where the amount of adsorbed metals reached: Cd 98,57%, Cu 69,76%, Pb 88,58%. P. azotoformans JAW1 exhibited a potential for application in the bioremediation of mining wastewater with complex metal contaminations. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. Microstructure, Magnetic, and Magnetoresistance Properties of La0.7Sr0.3MnO3:CuO Nanocomposite Thin Films.

    Science.gov (United States)

    Fan, Meng; Wang, Han; Misra, Shikhar; Zhang, Bruce; Qi, Zhimin; Sun, Xing; Huang, Jijie; Wang, Haiyan

    2018-02-14

    (La 0.7 Sr 0.3 MnO 3 ) 0.67 :(CuO) 0.33 (LSMO:CuO) nanocomposite thin films were deposited on SrTiO 3 (001), LaAlO 3 (001), and MgO (001) substrates by pulsed laser deposition, and their microstructure as well as magnetic and magnetoresistance properties were investigated. X-ray diffraction (XRD) and transmission electron microscopy (TEM) results show that LSMO:CuO films grow as highly textured self-assembled vertically aligned nanocomposite (VAN), with a systematic domain structure and strain tuning effect based on the substrate type and laser deposition frequency. A record high low-field magnetoresistance (LFMR) value of ∼80% has been achieved in LSMO:CuO grown on LaAlO 3 (001) substrate under high frequency. Detailed analysis indicates that both the strain state and the phase boundary effect play a significant role in governing the overall LFMR behavior.

  2. Purification of radionuclides for nuclear medicine

    International Nuclear Information System (INIS)

    Horwitz, E.P.; Bond, A.H.

    2002-01-01

    Novel systems for the rapid separation of 67 Cu, 90 Y, 188 Re, 212 Bi, 213 Bi, and 223 Ra are described. To achieve the high levels of decontamination required of radionuclides used in radioimmunotherapy, we have utilised combinations of ion exchange (IX) and novel extraction chromatographic (EXC) resins. The objective of each separation system is to remove by many orders of magnitude the parent isotopes and to reduce the concentrations of stable, sometimes adventitious impurities, to low levels. The latter objective is particularly important to achieve a high degree of bonding of radionuclide onto a monoclonal antibody. The purification of 212 Bi (60.6 min half-life) furnishes a good example of the level of purity that we have achieved using tandem combinations of EXC and IX resins. Bismuth-212 was separated from its daughters, 212 Pb, 224 Ra, 228 Th and 232 U at the 50 mCi level. The resultant 212 Bi decayed to background in a few days indicative of high purity. Another example of extraordinary removal of parent nuclide from daughter nuclide and subsequent purification of daughter from stable elements is the preparation of 90 Y. Strontium-90 was removed from 90 Y by > 10 9 . The purified 90 Y uptake by monoclonal antibodies was close to 100%

  3. Design of hypoxia-targeting radiopharmaceuticals: selective uptake of copper-64 complexes in hypoxic cells in vitro

    International Nuclear Information System (INIS)

    Dearling, J.L.J.; Lewis, J.S.; Mullen, G.E.D.; Rae, M.T.; Zweit, J.; Blower, P.J.

    1998-01-01

    The well-known perfusion tracer CuPTSM, labelled with 62 Cu or 64 Cu, is believed to be trapped in cells non-selectively by a bioreductive mechanism. It is proposed that by modifying the ligand to increase its electron donor strength (for example by adding alkyl functionality or replacing sulphur ligands with oxygen ligands), the copper complexes will become less easily reduced and tracers with selectivity for hypoxic tissues could thus be developed. The aim of this work was to prepare 64 Cu-labelled complexes of two series of ligands, based on the bis(thiosemicarbazone) (13 ligands) and bis(salicylaldimine) (3 ligands) skeletons, and to evaluate the hypoxia dependence of their uptake in cells. The complexes were incubated with Chinese hamster ovary cells under normoxic and hypoxic conditions, and the cells isolated by centrifugation to determine radioactivity uptake at various time points up to 90 min. Several members of both series demonstrated significant (P 60 Cu, 61 Cu, 62 Cu, 64 Cu) and targeted radiotherapy ( 64 Cu, 67 Cu). (orig.)

  4. Attrition Resistant Fischer-Tropsch Catalysts Based on FCC Supports

    Energy Technology Data Exchange (ETDEWEB)

    Adeyiga, Adeyinka

    2010-02-05

    Commercial spent fluid catalytic cracking (FCC) catalysts provided by Engelhard and Albemarle were used as supports for Fe-based catalysts with the goal of improving the attrition resistance of typical F-T catalysts. Catalysts with the Ruhrchemie composition (100 Fe/5 Cu/4.2 K/25 spent FCC on mass basis) were prepared by wet impregnation. XRD and XANES analysis showed the presence of Fe{sub 2}O{sub 3} in calcined catalysts. FeC{sub x} and Fe{sub 3}O{sub 4} were present in the activated catalysts. The metal composition of the catalysts was analyzed by ICP-MS. F-T activity of the catalysts activated in situ in CO at the same conditions as used prior to the attrition tests was measured using a fixed bed reactor at T = 573 K, P = 1.38 MPa and H{sub 2}:CO ratio of 0.67. Cu and K promoted Fe supported over Engelhard provided spent FCC catalyst shows relatively good attrition resistance (8.2 wt% fines lost), high CO conversion (81%) and C{sub 5}+ hydrocarbons selectivity (18.3%).

  5. Autoradiography of Sectioned Soil Cores; Autoradiographie de Carottes de Sol; Radioavtografiya otrezkov prob pochvy; Autorradiografia de Cortes de Testigos de Suelo

    Energy Technology Data Exchange (ETDEWEB)

    Held, E. E.; Gessel, S. P.; Matson, L. J.; Billings, R. F. [University of Washington, Seattle (United States)

    1965-10-15

    , sobrannye na Marshal'skih ostrovah. Radioaktivnye chasti prob mozhno otrezat' i proanalizirovat' pri pomoshhi spektroskopii gamma-luchej v celjah radiohimicheskogo analiza. Takim obrazom,predstavljaetsja vozmozhnym opredeljat' selektivnoe peremeshhenie i adsorbciju otdel'nyh radioizotopov v pochvenno-kornevoj sisteme rastenij. Glavnymi radioizotopami pochvy, kotorye byli izucheny pri pomoshhi jetogo metoda, byli: marganec-54, kobal't-60, stroncij-90, sur'ma-125, cezij-137, cerij-144, evropij-155 i plutonij-239. (author)

  6. (Pt{sub 1–x}Cu{sub x}){sub 3}Cu{sub 2}B and Pt{sub 9}Cu{sub 3}B{sub 5}, the first examples of copper platinum borides. Observation of superconductivity in a novel boron filled β-Mn-type compound

    Energy Technology Data Exchange (ETDEWEB)

    Salamakha, Leonid P. [Institute of Solid State Physics, TU Wien, A-1040 Wien (Austria); Sologub, Oksana, E-mail: oksana.sologub@univie.ac.at [Institute of Solid State Physics, TU Wien, A-1040 Wien (Austria); Stöger, Berthold [Institute of Chemical Technologies and Analytics, TU Wien, A-1040 Wien (Austria); Michor, Herwig; Bauer, Ernst [Institute of Solid State Physics, TU Wien, A-1040 Wien (Austria); Rogl, Peter F. [Institute of Physical Chemistry, University of Vienna, A-1090 Wien (Austria)

    2015-09-15

    New ternary copper platinum borides have been synthesized by arc melting of pure elements followed by annealing at 600 °C. The structures have been studied by X-ray single crystal and powder diffraction. (Pt{sub 1−x}Cu{sub x}){sub 3}Cu{sub 2}B (x=0.33) forms a B-filled β-Mn-type structure (space group P4{sub 1}32; a=0.6671(1) nm). Cu atoms are distributed preferentially on the 8c atom sites, whereas the 12d site is randomly occupied by Pt and Cu atoms (0.670(4) Pt±0.330(4) Cu). Boron is located in octahedral voids of the parent β-Mn-type structure. Pt{sub 9}Cu{sub 3}B{sub 5} (space group P-62m; a=0.9048(3) nm, c=0.2908(1) nm) adopts the Pt{sub 9}Zn{sub 3}B{sub 5–δ}-type structure. It has a columnar architecture along the short translation vector exhibiting three kinds of [Pt{sub 6}] trigonal prism columns (boron filled, boron semi-filled and empty) and Pt channels with a pentagonal cross section filled with Cu atoms. The striking structural feature is a [Pt{sub 6}] cluster in form of an empty trigonal prism at the origin of the unit cell, which is surrounded by coupled [BPt{sub 6}] and [Pt{sub 6}] trigonal prisms, rotated perpendicularly to the central one. There is no B–B contact as well as Cu–B contact in the structure. The relationships of Pt{sub 9}Cu{sub 3}B{sub 5} structure with the structure of Ti{sub 1+x}Os{sub 2−x}RuB{sub 2} as well as with the structure families of metal sulfides and aluminides have been elucidated. (Pt{sub 1–x}Cu{sub x}){sub 3}Cu{sub 2}B (x=0.3) (B-filled β-Mn-type structure) is a bulk superconductor with a transition temperature of about 2.06 K and an upper critical field μ{sub 0}H{sub C2}(0){sup WHH} of 1.2 T, whereas no superconducting transition has been observed up to 0.3 K in Pt{sub 9}Cu{sub 3}B{sub 5} (Pt{sub 9}Zn{sub 3}B{sub 5–δ}-type structure) from electrical resistivity measurements. - Highlights: • First two copper platinum borides, (Pt{sub 0.67}Cu{sub 0.33}){sub 3}Cu{sub 2}B and Pt{sub 9}Cu{sub 3}B

  7. ARRONAX, a high-energy and high-intensity cyclotron for nuclear medicine

    International Nuclear Information System (INIS)

    Haddad, Ferid; Guertin, Arnaud; Michel, Nathalie; Ferrer, Ludovic; Carlier, Thomas; Barbet, Jacques; Chatal, Jean-Francois

    2008-01-01

    This study was aimed at establishing a list of radionuclides of interest for nuclear medicine that can be produced in a high-intensity and high-energy cyclotron. We have considered both therapeutic and positron emission tomography radionuclides that can be produced using a high-energy and a high-intensity cyclotron such as ARRONAX, which will be operating in Nantes (France) by the end of 2008. Novel radionuclides or radionuclides of current limited availability have been selected according to the following criteria: emission of positrons, low-energy beta or alpha particles, stable or short half-life daughters, half-life between 3 h and 10 days or generator-produced, favourable dosimetry, production from stable isotopes with reasonable cross sections. Three radionuclides appear well suited to targeted radionuclide therapy using beta ( 67 Cu, 47 Sc) or alpha ( 211 At) particles. Positron emitters allowing dosimetry studies prior to radionuclide therapy ( 64 Cu, 124 I, 44 Sc), or that can be generator-produced ( 82 Rb, 68 Ga) or providing the opportunity of a new imaging modality ( 44 Sc) are considered to have a great interest at short term whereas 86 Y, 52 Fe, 55 Co, 76 Br or 89 Zr are considered to have a potential interest at middle term. Several radionuclides not currently used in routine nuclear medicine or not available in sufficient amount for clinical research have been selected for future production. High-energy, high-intensity cyclotrons are necessary to produce some of the selected radionuclides and make possible future clinical developments in nuclear medicine. Associated with appropriate carriers, these radionuclides will respond to a maximum of unmet clinical needs. (orig.) 5

  8. Use of copper radioisotopes in investigating disorders of copper metabolism

    International Nuclear Information System (INIS)

    Camakaris, J.; Voskoboinik, I.; Brooks, H.; Greenough, M.; Smith, S.; Mercer, J.

    1998-01-01

    Full text: Copper is an essential trace element for life as a number of vital enzymes require it. Copper deficiency can lead to neurological disorders, osteoporosis and weakening of arteries. However Cu is also highly toxic and homeostatic mechanisms have evolved to maintain Cu at levels which satisfy requirements but do not cause toxicity. Toxicity is mediated by the oxidative capacity of Cu and its ability to generate toxic free radicals. There are several acquired and inherited diseases due to either Cu toxicity or Cu deficiency. The study of these diseases facilitates identification of genes and proteins involved in copper homeostasis, and this in turn will provide rational therapeutic approaches. Our studies have focused on Menkes disease in humans which is an inherited and usually lethal copper deficiency. Using copper radioisotopes 64 Cu (t 1/2 = 12.8 hr) and 67 Cu (t 1/2 = 61 hr) we have studied the protein which is mutated in Menkes disease. This is a transmembrane copper pump which is responsible for absorption of copper into the body and also functions to pump out excess Cu from cells when Cu is elevated. It is therefore a vital component of normal Cu homeostasis. We have provided the first biochemical evidence that the Menkes protein functions as a P-type ATPase Cu pump (Voskoboinik et al., FEBS Letters, in press) and these data will be discussed. The assay involved pumping of radiocopper into purified membrane vesicles. Furthermore we have transfected normal and mutant Menkes genes into cells and are carrying out structure-function studies. We are also studying the role of amyloid precursor protein (APP) as a Cu transport protein in order to determine how Cu regulates this protein and its cleavage products. These studies will provide vital information on the relationship between Cu and APP and processes which lead to Alzheimers disease

  9. Evaluation of di-amino phenol substituted EDTA for use in radiolabelling proteins with 64Cu

    International Nuclear Information System (INIS)

    Schmidt, P.F.; Smith, S.V.; DiBartolo, N.M.

    1996-01-01

    This study involves a high yielding synthesis of a novel di-amino-phenol substituted EDTA (DAHA-EDTA) ligand and its radiolabelling chemistry with 64 Cu produced at the National Medical Cyclotron (NMC). High activity levels (up to 59.2 GBq EOB) of 64 Cu is co-produced during the production of 67 Ga from enriched 68 Zn. Waste eluent from the NMC 67 Ga production was evaporated to dryness and found to contain by products such as 57 Ni, 57 Co, 64 Cu, 67 Cu and 55 Co. A new method involving low acid concentration aqueous/organic mixtures with an anion exchange (AG 1-X8, BioRad) have been used to isolate the carrier-free 64 Cu. The specific activity of the 64 Cu (5 x 10 14 Bq/g) was found to be higher than that produce by Australian radioisotopes (ARI). The synthesis of the ligand involves the refluxing of EDTA anhydride in the presence of 4-nitro-2-amino-phenol in acetonitrile to produce the di-nitro derivative (DNHA- EDTA) in > 95% yield. The DNHA-EDTA is then reduced in the presence of activated palladium charcoal with sodium borohydride under an inert atmosphere at room temperature. The reaction mixture was acidified and the catalyst removed to obtain the final product, DAHA-EDTA. Labelling of proteins (B72.3, DD-3B6/22 and streptavidin) has been achieved with the DAHA-EDTA ligand. The reaction mixture is left to incubate for 1 h at 37 deg C and radiolabelled protein is then isolated using size exclusion chromatography

  10. Radiopharmaceutical development of radiolabelled peptides

    Energy Technology Data Exchange (ETDEWEB)

    Fani, Melpomeni; Maecke, Helmut R. [University Hospital Freiburg, Department of Nuclear Medicine, Freiburg (Germany)

    2012-02-15

    Receptor targeting with radiolabelled peptides has become very important in nuclear medicine and oncology in the past few years. The overexpression of many peptide receptors in numerous cancers, compared to their relatively low density in physiological organs, represents the molecular basis for in vivo imaging and targeted radionuclide therapy with radiolabelled peptide-based probes. The prototypes are analogs of somatostatin which are routinely used in the clinic. More recent developments include somatostatin analogs with a broader receptor subtype profile or with antagonistic properties. Many other peptide families such as bombesin, cholecystokinin/gastrin, glucagon-like peptide-1 (GLP-1)/exendin, arginine-glycine-aspartic acid (RGD) etc. have been explored during the last few years and quite a number of potential radiolabelled probes have been derived from them. On the other hand, a variety of strategies and optimized protocols for efficient labelling of peptides with clinically relevant radionuclides such as {sup 99m}Tc, M{sup 3+} radiometals ({sup 111}In, {sup 86/90}Y, {sup 177}Lu, {sup 67/68}Ga), {sup 64/67}Cu, {sup 18}F or radioisotopes of iodine have been developed. The labelling approaches include direct labelling, the use of bifunctional chelators or prosthetic groups. The choice of the labelling approach is driven by the nature and the chemical properties of the radionuclide. Additionally, chemical strategies, including modification of the amino acid sequence and introduction of linkers/spacers with different characteristics, have been explored for the improvement of the overall performance of the radiopeptides, e.g. metabolic stability and pharmacokinetics. Herein, we discuss the development of peptides as radiopharmaceuticals starting from the choice of the labelling method and the conditions to the design and optimization of the peptide probe, as well as some recent developments, focusing on a selected list of peptide families, including somatostatin

  11. Development and validation of a simple model for cellular and cell cluster dosimetry with practical application in targeted radionuclide therapy

    International Nuclear Information System (INIS)

    Bardies, M.; Myers, M.J.

    1992-01-01

    The authors have developed an analytical technique for calculating the mean absorbed dose to the cell nucleus from a variety of spatial distributions of cells and activities and a wide range of emitted energies and radionuclides. The dose to the nucleus has been calculated using this method from activity distributed (1) on the cell surface (2) throughout the cytoplasm (3) throughout a cluster of cells (micrometastasis) and (4) on the surface of the cluster of cells. The derived absorption factors have been based on the latest point kernels of Berger and have been validated against published estimates. They show good agreement and the model has the advantage of being easily adapted for revisions and extensions of available low energy data. Data sets may be derived with the absorbed fractions or the absorbed dose per emission as a function of the radial extent of the activity, and either the individual energies of the emissions or the totality of the emissions from a particular radio-nuclide. The practical applications of the model have included: (a) calculation of the absorbed dose to radioimmuno-targeted micrometastasis in the peritoneum; (b) calculations of doses to cells labelled on the surface with some novel emitters such as 67 Cu, 177 Lu, 153 Sm, 111 Ag, 186 Re, 188 Re as well as 131 I, 125 I and 90 Y; (c) comparison of doses to the cell nucleus from MIBG labelled with 125 I and 131 I and distributed in the cytoplasm of the cell; and (d) estimates of the absorbed dose to the cell nucleus from alpha emitters distributed on the surface of the cell

  12. Performance Characteristics of the Experimental Boiling Water Reactor from 0 to 100 MW(t); Performances de l'EBWR de 0 a 100 MW; Rabochaya kharakteristika ehksperimental'nogo kipyashchego reaktora EBWR pri moshchnosti 0 - 100 mgvt.; Rendimiento del reactor experimental de agua hirviente (EBWR) entre 0 y 100 MW

    Energy Technology Data Exchange (ETDEWEB)

    Iskenderian, A.; Lipinski, W. C.; Petrick, M.; Wimunc, E. A. [Argonne National Laboratory, Argonne, IL (United States)

    1963-10-15

    entonces de comportarse como reactor de agua hirviente de ciclo directo; en cierto modo, funciona como reactor de ciclo doble y circulacion natural. (author) [Russian] 25 maya 1962 goda Argonnskaya natsional'naya laboratoriya poluchila razreshenie KAEH SSHA na ehkspluatatsiyu reaktora EBWR na moshchnosti 100 mgvt. Administrativnoe razreshenie na ehkspluatatsiyu reaktora bylo predostavleno sistemoj garantij. Mezhdunarodnogo agentstva po atomnoj ehnergii 11 iyulya 1961 goda. 15 noyabrya 1962 goda byl dostignut uroven' moshchnosti v 100 mgvt. 6 dekabrya 1962 goda ehksperimental'naya programma byla zakonchena. Odnoj iz osnovnykh tselej ee byla tshchatel'naya proverka reaktora dlya polucheniya dannykh i informatsii rabochej kharakteristiki ehtogo tipa reaktora. Ehta programma byla pervoj programmoj takogo roda i pervoj vypolnennoj programmoj. Dlya polucheniya nuzhnykh dannykh neobkhodimo bylo razrabotat' mnogie novye pribory. TSel' byla dostignuta, polucheno mnogo novykh dannykh o rabochej kharakteristike kipyashchego reaktora s estestvennoj tsirkulyatsiej. Tak,naprimer, poluchena informatsiya otnositel'no skorosti potoka tsirkulyatsii v zamknutom tsikle, predelov separatsii zhidkogo para (vydelenie para v osadok v spusknoj trube i unos zhidkosti ehflu- entom para), nedogreva, lokalizatsii dejstvitel'noj poverkhnosti razdela v reaktore i ee svyazi s urovnem vodnoj kolonki, skorosti razrusheniya para v spusknoj trube, pustotnykh koehffitsientov, reaktivnoj sposobnosti H{sub 3}BO{sub 3}, temperaturnykh koehffitsientov, ispol'zovaniya sterzhnej iz bora dlya tselej kontrolya, ispol'zovaniya svezhikh toplivnykh ehlementov, peredatochnykh funktsij,analiza shuma, nekotorykh izmerenij potoka, stabil'nosti i t.d. Krome togo, byli polucheny dannye o povedenii i tselostnosti nekotorykh reaktornykh komponentov i sistem, takikh, kak bornokislaya kontrol'naya reaktsiya, urovni radiatsii, raspredelenie produktov korrozii, vykhod iz stroya oborudovaniya, toplivo i reguliruyushchie sterzhni i t

  13. Removal of radiostrontium from man; Elimination du radiostrontium de l'organisme humain; Vyvedenie radioaktivnogo strontsiya iz organizma cheloveka; Eliminacion del radioestroncio por el organismo humano

    Energy Technology Data Exchange (ETDEWEB)

    Spencer, H. [Edward Hines, Jr. Hospital Hines, IL (United States)

    1963-02-15

    normal que se ofrecieron como voluntarios. En este estudio no se administraron radioisotopos. Los resultados relativos al {sup 90}Sr son analogos a los conseguidos con el 8{sup 5}Sr. (author) [Russian] Issledovanie obmena radiostrontsiya u cheloveka proizvodilos' pri postoyannom kontrole.obmena i diety. V kachestve radioaktivnogo indikatora byl ispol'zovan otnositel'no korotkokhivushchij izotop Sreb. Odnokratnye indikatornye dozy Sr{sup 85} vvodilis' vnutrivenno i davalis' vnutr', posle chego opredelyalsya uroven' ego v plazme i vydelenie s mochoj i kalom. Osnovnoe kolichestvo Sr{sup 85} vyvoditsya pochkami, nezavisimo ot puti vvedeniya indikatora. U bol'shinstva obsledovannykh v srednem 20% prinyatogo vnutr' kolichestva Sr{sup 85} poglashchalos' iz kishechnika i priblizitel'no 50% pogloshchennoj dozy vydelyalos' s mochoj za 12 dnej. Issledovaniya, v protsesse kotorykh indikatornye dozy Sr{sup 85} i Ca{sup 45} byli odnovremenno vvedeny per oa, ukazali na predpochtenie organizma k pogloshcheniyu Ca{sup 45} i k vydeleniyu Sr{sup 85}, prichem sootnoshenie po- gloshcheniya Ca{sup 45}/Sr{sup 85} sostavlyaet 2,6:1. Zakonchivshiesya issledovaniya Sr{sup 85} vo vremya priema bol'shikh i malykh doz kal'tsiya odnimi i temi khe litsami pokazali, chto priem bol'shogo kolichestva kal'tsiya ne vedet k kakomulibo zametnomu izmeneniyu v pogloshchenii Sr{sup 85} u bol'shinstva obsledovannykh. Poskol'ku vydelenie Sr{sup 85} mochoj idet parallel'no vydeleniyu kal'tsiya, okazalos' vozmozhnym uvelichit' soderzhanie kal'tsiya v moche s pomoshch'yu razlichnykh veshchestv, povyshayushchikh kal'tsiuriyu. Vvedennye vnutrivenno stabil'nye kal'tsij i strontsij i prinyatyj per os khloristyj ammonij, primenennye v chistom vide ili v sochetanii s vnutrivenno vvedennymi kal'tsiem i nekotorymi kompleksoobrazuyushchimi veshchestvami, okazalis' ehffektivnymi v otnoshenii udaleniya radiostrontsiya u cheloveka v period ot dvukh do chetyrekh nedel' posle inektsii indikatora. Proizvedeny takzhe issledovaniya

  14. Preparation of Uranium Dioxide by Electrochemical Reduction in Ammonium Carbonate Solutions and Subsequent Precipitation; Preparation de bioxyde d'uranium par reduction electrochimique dans des solutions de carbonate d'ammonium et precipitation; Prigotovlenie dvuokisi urana metodom ehlektrokhimicheskogo vosstanovleniya v rastvore karbonata ammoniya s posleduyushchim osazhdeniem; Preparacion de dioxido de uranio por reduccion electroquimica en soluciones de carbonato amonico u precipitacion subsiguiente

    Energy Technology Data Exchange (ETDEWEB)

    Pravdic, V.; Branica, M.; Pucar, Z. [Department of Physical Chemistry, Rudjer Boskovic Institute, Zagreb, Yugoslavia (Serbia)

    1963-11-15

    dvumya 50-litrovymi rezervuarami i podavalsya k intensivno peremeshivaemomu rtutnomu katodu. Rabochij potentsial rtuti proveryalsya po ehlektrodu sravneniya Ag/AgCl/KCl (Sat.). Potentsial podderzhivalsya postoyannogo znacheniya - 1,5 vol't. Proizvoditel'nost' po toku byla okolo 90%, dlya protsessa vosstanovleniya potreblyaemaya ehnergiya sostavlyala okolo 0,8 kvt-chas/kg dvuokisi urana. Po okonchanii ehlektroliza osazhdenie initsiirovali tol'ko pri pomoshchi nagreva temnozelenogo, prozrachnogo rastvora do temperatury 70 deg. C v spetsial'nom steklyannom sosude ob''emom 60 1. Iz 50 1 katalicheskogo rastvora poluchili 1 kg tsentrifugirovannogo produkta (soderzhanie vody okolo 20%). Kulonometricheskij analiz otnosheniya O/U daval vsegda rezul'taty, lezhashchie v predelakh ot 2,04 do 2,0. Opisannym sposobom gidrookis' urana (IV) osazhdaetsya selektivno. Ustanovleno, chto otnoshenie O/U v osadke ne zavisit ot polnoty vosstanovleniya. Pri pomoshchi rentgenoskopii produkt identifitsirovan kak al'fa-faza dvuokisi urana. Opyty po spekaniyu i kharakteristike poluchennoj takim obrazom dvuokisi urana, prigodnoj dlya keramicheskogo yadernogo topliva, prodolzhayutsya. (author)

  15. Selective Neoplasm Localization with Mercury-197 Neohydrin; Localisation Selective de Neoplasmes a l'aide de la Neohydrine Marquee avec {sup 197}hg; Obnaruzhenie opukholej s pomoshch'yu neogidrina, mechennogo rtut'yu-197; Localizacion Selectiva de Neoplasmas con Neohidrina - {sup 197}hg

    Energy Technology Data Exchange (ETDEWEB)

    Sodee, D. B. [Doctors Hospital and Renner Clinic Foundation, Cleveland Heights, OH (United States)

    1964-10-15

    parecer, la sustancia radiactiva tiende a depositarse selectivamente en regiones intercelulares. Con los aparatos de exploracion de. tipo comercial se pueden delinear facilmente las zonas de mayor absorcion de radiactividad. Tambien se comprobo la utilidad de la neohidrina-{sup 197}Hg para la diferenciacion de tumores oculares en una serie de 88 pacientes - recientemente se ha observado que este compuesto radiofarmaceutico de baja energia se concentra en los tumores nasofaringeos que luego pueden delinearse por fotoexploracion. La dosis diagnostica de neohidrina-{sup 197}Hg administrada para la exploracion del cerebro entrafla la absorcion de 3 rad por el riflon; la de neohidrina-{sup 203}Hg entrafla la absorcion de 70 rad por este ultimo organo. El elevado rendimiento de recuento del {sup 197}Hg y la facilidad con que se coliman las radiaciones que emite, hacen que este isotopo resulte mucho mas util para la exploracion gammagra-fica que cualquier otro de los agentes habitualmente empleados. (author) [Russian] RtuT'-197-izluchatel' rentgenovskih i gamma-luchej maloj jenergii (period poluraspada 2,7 dnja, konversionnoe rentgenovskoe izluchenie moshhnost'ju 69 kjev, gamma-izluchenie 77 kjev) byl oprobovan v kachestve skennirujushego sredstva v bol'shogo kolichestva bol'nyh. U 500 bol'nyh s predpolagaemymi nervohirurgicheskimi zabolevanijami proizvedeno skennirovanie po izlucheniju neogidrina, mechennogo Hg{sup 197}. S pomoshh'ju metoda fotOskennirovanija udalos' vyjavit' porazhenie sosudov i opuholi, prichem jeta metodika v 96% obespechivala korreljaciju s okonchatel'nym diagnozom. Jeta metodika rentgenologicheskogo issledovanija predshestvovala vsem drugim vidam diagnosticheskogo obsledovanija. S pomoshh'ju metoda skennirovanija golovnogo mozga avtory obnaruzhili lokalizaciju Neogidrina-Hg{sup 197} kak v limfomah, tak i v karcinomah. Po-vidimomu, imeet mesto mezhkletochnoe selektivnoe otlozhenie radioaktivnogo veshhestva. Uchastki usilennogo pogloshhenija radioaktivnosti

  16. Radioisotope Scanning of the Pancreas with Selenomethionine-Se{sup 75}; Gammagraphie du Pancreas a l'Aide de la Selenomethionine-{sup 75}Se; Diagnosticheskoe fotoskennirovanie podzheludochnoj zhelezy; Gammagrafia del Pancreas Mediante Radioisotopos

    Energy Technology Data Exchange (ETDEWEB)

    Sodee, D. B. [Doctors Hospital and Renner Clinic Foundation, Cleveland Heights, OH (United States)

    1964-10-15

    voznikajushhee v rezul'tate koncentraciiselenometionina - {sup 75}Se v pecheni izluchenie, kotoroe v proshlom meshalo tochnomu opredeleniju kontura podzheludochnoj zhelezy. Nedavno avtory ispol'zovali kristall razmerom 12,5 h 7,5 sm i 121-kanal'nyj svincovyj kollimator s fokusnym rasstojaniem 12,5 sm. Jeto uluchshilo kachestvo izobrazhenija, i po mere usovershenstvovanija metodiki mozhno budet, verojatno, videt' men'shie povrezhdenija na bol'shej glubine. Okazalos',chto karcinoma podzheludochnoj zhelezy koncentriruet selenometionina -Se75 . huzhe, chem normal'naja tkan'. S pomoshh'ju jetoj metodiki udalos' pravil'no istolkovat' zabolevanie u 5 iz 6 bol'nyh, stradajushhih karcinomoj podzheludochnoj zhelezy. Nepoddajushhiesja obnaruzheniju Mel'chajshie karcinomatoznye uzly byli zatemneny uvelichennoj pechen'ju. Diagnoz ostrogo i hronicheskogo pankreatita takzhe podtverzhdaetsja skennirovaniem podzheludochnoj zhelezy, poskol'ku povrezhdennye kletki podzheluzhochnoj zhelezy ne koncentrirujut selenometionin -{sup 75}Se. Avtor takzhe opisyvaet izbiratel'noe pogloshhenie selenometionina -{sup 75}Se tkan'ju para- shhitovidnoj zhelezy . S pomoshh'ju jetogo zhe metoda skennirovanija byli obnaruzheny adenomy parashhitovidnoj zhelezy u nebol'shoj gruppy bol'nyh s povyshennoj funkciej parashhitovid- noj zhelezy. Fotoskennirovanie podzheludochnoj zhelezy uzhe javljaetsja prakticheskim metodom, i v nastojashhee vremja vedetsja izuchenie fotoskennirovanija parashhitovidnoj zhelezy. Narjadu s vnov' probudivshimsja interesom k organam, kotorye byli nevidimy pri obychnyh radiograficheskih metodah, selektivnoe skennirovanie organov s pomoshh'ju soedinenij,soderzhashhih mechenye atomy i podobrannyh po ih biohemicheskim svojstvam, stanovitsja vazhnym metodom budushhego. (author)

  17. Comparison of the Economic Aspects of the Treatment and Storage of Fission Products from Installations Processing Irradiated Natural Uranium; Aspects Economiques Compares du Traitement et du Stockage des Produits de Fission Issus des Usines de Traitement de l'Uranium Naturel Irradie; Sravnitel'nye ehkonomicheskie aspekty obrabotki i khraneniya produktov deleniya, poluchaemykh na zavodakh po pererabotke obluchennogo prirodnogo urana; Aspectos Economicos Comparados del Tratamiento y del Almacenamiento de los Productos de Fision que Salen de las Plantas de Tratamiento de Uranio Natural Irradiado

    Energy Technology Data Exchange (ETDEWEB)

    Thiriet, L.; Lesur, P.; Giraud, R. [Commissariat a l' Energie Atomique, Paris (France); Wanlin, J. [Societe Saint-Gobain Techniques Nouvelles, Paris (France)

    1966-02-15

    instalaciones, tipo de interes y gastos de explotacion) la eleccion de la politica Optima (dimensiones y ritmo de la puesta en servicio) es en cambio independiente de estas hipotesis y esta unicamente ligada a la ley de variacion del costo de los depositos en funcion de sus dimensiones. Se obtiene, asi, el costo optimizado del almacenamiento de los efluentes por tiempo indefinido. En la tercera parte se compara la solucion del almacenamiento indefinido con otras posibilidades: vitrificacion y separacion del Cs y del Sr. Los autores analizan esas posibilidades desde el punto de vista economico e indican algunas soluciones a largo plazo. (author) [Russian] Posle upominanija osnovnyh metodov obrashhenija s produktami delenija v zhidkom vide, daetsja kratkoe opisanie osnovnyh tehnicheskih harakteristik primenjaemyh vo Francii ustanovok dlja hranenija iz nerzhavejushhej stali (v kisloj srede) i struktury stoimosti jetih ustanovok. Pokazyvaetsja, kak jeta sistema zavisit ot aktivnosti nahodjashhihsja na hranenii rastvorov i ot vydelenija imi tepla. Vo vtoroj chasti issleduetsja stoimost' ih hranenija v zavisimosti ot razmerov rezervuarov, kotorye mogut byt' postroeny, i opredeljajutsja razmery i maksimal'nye predely ih ispol'zovanija s uchetom harakteristik podlezhashhih hraneniju produktov delenija i razlichnyh vozmozhnostej zavoda po pererabotke obluchennogo prirodnogo urana. Pokazyvaetsja, chto esli stoimost' hranenija predpolozhitel'no zavisit ot sroka sluzhby ustanovok, procenta na kapital i jekspluatacionnyh rashodov, to vybor optimal'nogo metoda nezavisim ot jetogo i svjazan lish' s zakonom izmenenija stoimosti jetih rezervuarov s uchetom ih razmerov. Takim putem poluchajut optimizirovannuju stoimost' beskonechnogo hranenija zhidkih produktov. V tret'ej chasti s jetim resheniem beskonechnogo hranenija sravnivajutsja drugie vozmozhnye mery obrashhenija s produktami delenija: osteklovyvanie i vydelenie cezija i stroncija. Obsuzhdaetsja jekonomika razlichnyh metodov hranenija i

  18. Electrical characteristics of sphere-plane type spark counters; Caracteristiques electriques de compteurs a etincelles du type sphere-plan; Ehlektricheskie kharakteristiki iskrovykh schetchikov tipa shar-ploskost'; Caracteristicas electricas de los contadores de chispas del tipo esfera-plano

    Energy Technology Data Exchange (ETDEWEB)

    Laborie, P; Blanc, D [Centre de Physique Nucleaire, Faculte des Sciences de Toulouse (France)

    1962-04-15

    quelques millimetres cubes, est tres bien defini, ce qui permet la construction de telescopes precis. (author) [Spanish] Los autores describen los detalles mecanicos y las caracteristicas de funcionamiento de unos detectores de chispas en que se utiliza como anodo una esfera de pequeno diametro (0,30 mm), dispuesta frente a un catodo plano y que funcionan en regimen de efecto , en aire a presion atmosferica. Las caracteristicas de contaje son semejantes a las de los detectores de anodo de alambre, de tipo Rosenblum. No obstante, el contador de esfera presenta, con respecto a dicho contador Rosenblum, cierto numero de ventajas derivadas de su geometria: a) la corriente residual (ruido de fondo) es debil y el desprendimiento de ozono y de oxidos de nitrogeno, con las chispas, es poco considerable; b) como su capacidad propia es muy pequena, el detector ofrece una respuesta mas rapida; c) la eficiencia es independiente de la direccion de incidencia de la particula, al reves de lo que ocurre con los contadores de alambre; d) el volumen sensible de revolucion en torno del eje de simetria del detector es de algunos milimetros cubicos y esta muy bien definido, lo que permite la construccion de telescopios de gran precision. (author) [Russian] Avtory opisyvayut mekhanicheskuyu konstruktsiyu i rabochie kharakteristiki iskrovykh schetchikov, v kotorykh v kachestve anoda ispol'zuetsya shar malogo diametra (0,30 mm), raspolozhennyj protiv ploskogo katoda. Ehti schetchiki rabotayut v rezhime ''kol'tsevogo'' yavleniya (''korony'') v vozdukhe pri atmosfernom davlenii. Schetnye kharakteristiki blizki k kharakteristikam schetchikov Rozenblyuma s anodnym provodom. Sharovoj schetchik imeet, odnako, nekotorye preimushchestva po sravneniyu so schetchikom Rozenblyuma, chto svyazano s ego geometriej: 1. ostatochnyj tok (fon) slabyj, a vydelenie ozona i okisi azota vo vremya iskreniya neznachitel'no. 2. Poskol'ku ego sobstvennaya emkost' ochen' mala, schetchik daet bolee bystryj otvet. 3

  19. Structural and magnetic characterization of as-prepared and annealed FeCoCu nanowire arrays in ordered anodic aluminum oxide templates

    Energy Technology Data Exchange (ETDEWEB)

    Rodríguez-González, B., E-mail: jbenito@uvigo.es [CACTI, University of Vigo, E-36310 Vigo (Spain); International Iberian Nanotechnology Laboratory, INL. Av. Mestre J. Veiga, 4715-330 Braga (Portugal); Bran, C.; Warnatz, T.; Vazquez, M. [Institute of Materials Science of Madrid, CSIC, 28049 Madrid (Spain); Rivas, J. [International Iberian Nanotechnology Laboratory, INL. Av. Mestre J. Veiga, 4715-330 Braga (Portugal)

    2014-04-07

    Herein, we report on the preparation, structure, and magnetic characterization of FeCoCu nanowire arrays grown by DC electrodeposition inside self-assembled ordered nanopores of anodic aluminum oxide templates. A systematic study of their structure has been performed both in as-prepared samples and after annealing in the temperature range up to 800 °C, although particular attention has been paid to annealing at 700 °C after which maximum magnetic hardening is achieved. The obtained nanowires have a diameter of 40 nm and their Fe{sub 0.28}Co{sub 0.67}Cu{sub 0.05} composition was confirmed by energy dispersive X-ray spectroscopy (EDS). Focused ion-beam lamellas of two samples (as-prepared and annealed at 700 °C) were prepared for their imaging in the high-resolution transmission electron microscopy (HRTEM) perpendicularly to the electron beam, where the obtained EDS compositional mappings show a homogeneous distribution of the elements. X-ray diffraction analysis, and selected area electron diffraction (SAED) patterns confirm that nanowires exhibit a bcc cubic structure (space group Im-3m). In addition, bright-dark field images show that the nanowires have a polycrystalline structure that remains essentially the same after annealing, but some modifications were observed: (i) an overall increase and sharpening of recrystallized grains, and (ii) an apparent shrinkage of the nanowires diameter. Obtained SAED patterns also show strong textured components with determined <111> and <112> crystalline directions parallel to the wires growth direction. The presence of both directions was also confirmed in the HRTEM images doing Fourier transform analyses. Magnetic measurements show strong magnetic anisotropy with magnetization easy axis parallel to the nanowires in as-prepared and annealed samples. The magnetic properties are tuned by suitable thermal treatments so that, maximum enhanced coercivity (∼2.7 kOe) and normalized remanence (∼0.91 Ms) values are

  20. Structural and magnetic characterization of as-prepared and annealed FeCoCu nanowire arrays in ordered anodic aluminum oxide templates

    International Nuclear Information System (INIS)

    Rodríguez-González, B.; Bran, C.; Warnatz, T.; Vazquez, M.; Rivas, J.

    2014-01-01

    Herein, we report on the preparation, structure, and magnetic characterization of FeCoCu nanowire arrays grown by DC electrodeposition inside self-assembled ordered nanopores of anodic aluminum oxide templates. A systematic study of their structure has been performed both in as-prepared samples and after annealing in the temperature range up to 800 °C, although particular attention has been paid to annealing at 700 °C after which maximum magnetic hardening is achieved. The obtained nanowires have a diameter of 40 nm and their Fe 0.28 Co 0.67 Cu 0.05 composition was confirmed by energy dispersive X-ray spectroscopy (EDS). Focused ion-beam lamellas of two samples (as-prepared and annealed at 700 °C) were prepared for their imaging in the high-resolution transmission electron microscopy (HRTEM) perpendicularly to the electron beam, where the obtained EDS compositional mappings show a homogeneous distribution of the elements. X-ray diffraction analysis, and selected area electron diffraction (SAED) patterns confirm that nanowires exhibit a bcc cubic structure (space group Im-3m). In addition, bright-dark field images show that the nanowires have a polycrystalline structure that remains essentially the same after annealing, but some modifications were observed: (i) an overall increase and sharpening of recrystallized grains, and (ii) an apparent shrinkage of the nanowires diameter. Obtained SAED patterns also show strong textured components with determined and crystalline directions parallel to the wires growth direction. The presence of both directions was also confirmed in the HRTEM images doing Fourier transform analyses. Magnetic measurements show strong magnetic anisotropy with magnetization easy axis parallel to the nanowires in as-prepared and annealed samples. The magnetic properties are tuned by suitable thermal treatments so that, maximum enhanced coercivity (∼2.7 kOe) and normalized remanence (∼0.91 Ms) values are achieved after annealing at

  1. Anti-L1CAM radioimmunotherapy is more effective with the radiolanthanide terbium-161 compared to lutetium-177 in an ovarian cancer model

    International Nuclear Information System (INIS)

    Gruenberg, Juergen; Lindenblatt, Dennis; Cohrs, Susan; Fischer, Eliane; Dorrer, Holger; Zhernosekov, Konstantin; Koester, Ulli; Tuerler, Andreas; Schibli, Roger

    2014-01-01

    The L1 cell adhesion molecule (L1CAM) is considered a valuable target for therapeutic intervention in different types of cancer. Recent studies have shown that anti-L1CAM radioimmunotherapy (RIT) with 67 Cu- and 177 Lu-labelled internalising monoclonal antibody (mAb) chCE7 was effective in the treatment of human ovarian cancer xenografts. In this study, we directly compared the therapeutic efficacy of anti-L1CAM RIT against human ovarian cancer under equitoxic conditions with the radiolanthanide 177 Lu and the potential alternative 161 Tb in an ovarian cancer therapy model. Tb was produced by neutron bombardment of enriched 160 Gd targets. 161 Tb and 177 Lu were used for radiolabelling of DOTA-conjugated antibodies. The in vivo behaviour of the radioimmunoconjugates (RICs) was assessed in IGROV1 tumour-bearing nude mice using biodistribution experiments and SPECT/CT imaging. After ascertaining the maximal tolerated doses (MTD) the therapeutic impact of 50 % MTD of 177 Lu- and 161 Tb-DOTA-chCE7 was evaluated in groups of ten mice by monitoring the tumour size of subcutaneous IGROV1 tumours. The average number of DOTA ligands per antibody was 2.5 and maximum specific activities of 600 MBq/mg were achieved under identical radiolabelling conditions. RICs were stable in human plasma for at least 48 h. 177 Lu- and 161 Tb-DOTA-chCE7 showed high tumour uptake (37.8-39.0 %IA/g, 144 h p.i.) with low levels in off-target organs. SPECT/CT images confirmed the biodistribution data. 161 Tb-labelled chCE7 revealed a higher radiotoxicity in nude mice (MTD: 10 MBq) than the 177 Lu-labelled counterpart (MTD: 12 MBq). In a comparative therapy study with equitoxic doses, tumour growth inhibition was better by 82.6 % for the 161 Tb-DOTA-chCE7 than the 177 Lu-DOTA-chCE7 RIT. Our study is the first to show that anti-L1CAM 161 Tb RIT is more effective compared to 177 Lu RIT in ovarian cancer xenografts. These results suggest that 161 Tb is a promising candidate for future clinical

  2. A systematic study of odd-odd Gallium nuclei

    International Nuclear Information System (INIS)

    Allegro, P.R.P.; Medina, N.H.; Oliveira, J.R.B.; Ribas, R.V.; Cybulska, E.W.; Seale, W.A.; Zagatto, V.A.B.; Zahn, G.S.; Genezini, F.A.; Silveira, M.A.G.; Tabor, S.; Bender, P.; Tripathi, V.; Baby, L.

    2012-01-01

    Full text: Recently, many studies have been published attempting to explain the role of the 0g 9/2 orbital in the high spin excited states of nuclei in the region of the mass A=50-80, especially very neutron rich nuclei like, for example 59-66 Fe [1], 65,67 Cu [2], 70,80 Ge [3,4] nuclei and those with odd mass number like As, Ge and Ga [5]. Stefanescu et al. [6] demonstrated the presence of bands in the neutron-rich isotopes Ga formed from excitation of a proton to the 0g 9/2 orbital and Cheal et al. [7] revealed, from the study of the spins and moments of the ground state, changes in nuclear structure of the odd Ga isotopes between N = 40 and N 50, indicating a change in the energy gap between the 0g 9/2 orbital and the pf shell. In this work, we have performed a systematic study of odd-odd 64,66,68,70 Ga nuclei to examine the behavior of the 0g 9/2 orbital with an increasing number of neutrons. We have compared the predictions of the Large Scale Shell Model, obtained using the Antoine code [8] with the FPG [9] and JUN45 [10] effective interactions, with the experimental results obtained with in-beam gamma-ray spectroscopy experiments performed at University of Sao Paulo using SACI-PERERE spectrometer and at Florida State University using the Clover Array System. We have also performed calculations to study 67 Ge, an odd nucleus in the same mass region, in order to verify the behavior of the effective interactions in a nucleus without the proton-neutron interaction. [1] S. Lunardi. et al., Phys. Rev. C 76, 034303 (2007). [2] C. J. Chiara et al., Phys. Rev. C 85, 024309 (2012). [3] M. Sugawara et al., Phys. Rev. C 81, 024309 (2010). [4] H. Iwasaki.et al., Phys. Rev. C 78, 021304(R) (2008). [5] N. Yoshinaga et al. Phys. Rev. C 78, 044320 (2008). [6] I. Stefanescu et al., Phys. Rev. C 79, 064302 (2009). [7] B. Cheal et al. Phys. Rev. Lett. 104, 252502 (2010). [8] E. Caurier and F. Nowacki, Acta Phys. Polonica B 30, 705 (1999). [9] O. Sorlin et al., Phys. Rev. Lett

  3. Research reactors serving the radiotracer technique: An overlooked opportunity?

    International Nuclear Information System (INIS)

    Bode, P.

    2010-01-01

    The unique features of using radiotracers are not always fully explored at nuclear research reactor centers. The radiotracer method is a versatile and powerful tool in the study of a wide variety of applications in e.g. chemistry, biology, agriculture, medicine and (industrial) technology. The big advantage of radiotracers above e.g. stable isotope tracers, commonly applied in e.g. nutritional studies, is that radiotracers allow for non-invasive studies of both steady-state and dynamic systems, in equilibrium situations and for transport and exchange phenomena and thus provide information on the chemical and/or physical status of elements. The radiotracer method does not imply huge equipment investments but rather requires that the four interrelated aspects: experimental designs, data treatment including tracer kinetic analysis and data interpretation are careful considered. Radiotracer production with reactors often implies additional fundamental research to use smart nuclear reactions and chemical separations so as to obtain an almost no-carrier added tracer. Nuclear analytical groups, already equipped with gamma-ray spectrometers, can thus extend their research program. Using Ge-spectrometers, multi-labeling experiments are possible which allow for unique applications if different radionuclides exist for the same element, such as 65 Zn and 69m Zn or 64 Cu and 67 Cu. The developments in novel scintillation detectors, room-temperature semiconductor detectors (like CdZnTe) and position-sensitive detectors open the door for an entire new scope of radiotracer applications, such as SPECT. Once applied to in-vitro studies with cell cultures, the nuclear analytical group may position itself into the worlds of medical research, biochemistry and biotechnology. Radiotracers can be used to study the properties of drug-delivering compounds as used in e.g, cancer therapy. Radiotracers can be added as a label to solid particles, to liquids but may also be applied in the

  4. Anti-L1CAM radioimmunotherapy is more effective with the radiolanthanide terbium-161 compared to lutetium-177 in an ovarian cancer model

    Energy Technology Data Exchange (ETDEWEB)

    Gruenberg, Juergen; Lindenblatt, Dennis; Cohrs, Susan; Fischer, Eliane [Paul Scherrer Institute, Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Villigen (Switzerland); Dorrer, Holger [Paul Scherrer Institute, Laboratory of Radiochemistry and Environmental Chemistry, Villigen (Switzerland); Zhernosekov, Konstantin [ITG Isotope Technologies Garching GmbH, Garching (Germany); Koester, Ulli [Institut Laue-Langevin, Grenoble (France); Tuerler, Andreas [Paul Scherrer Institute, Laboratory of Radiochemistry and Environmental Chemistry, Villigen (Switzerland); University of Bern, Department of Chemistry and Biochemistry, Berne (Switzerland); Schibli, Roger [Paul Scherrer Institute, Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Villigen (Switzerland); ETH Zurich, Department of Chemistry and Applied Biosciences, Zurich (Switzerland)

    2014-10-15

    The L1 cell adhesion molecule (L1CAM) is considered a valuable target for therapeutic intervention in different types of cancer. Recent studies have shown that anti-L1CAM radioimmunotherapy (RIT) with {sup 67}Cu- and {sup 177}Lu-labelled internalising monoclonal antibody (mAb) chCE7 was effective in the treatment of human ovarian cancer xenografts. In this study, we directly compared the therapeutic efficacy of anti-L1CAM RIT against human ovarian cancer under equitoxic conditions with the radiolanthanide {sup 177}Lu and the potential alternative {sup 161}Tb in an ovarian cancer therapy model. Tb was produced by neutron bombardment of enriched {sup 160}Gd targets. {sup 161}Tb and {sup 177}Lu were used for radiolabelling of DOTA-conjugated antibodies. The in vivo behaviour of the radioimmunoconjugates (RICs) was assessed in IGROV1 tumour-bearing nude mice using biodistribution experiments and SPECT/CT imaging. After ascertaining the maximal tolerated doses (MTD) the therapeutic impact of 50 % MTD of {sup 177}Lu- and {sup 161}Tb-DOTA-chCE7 was evaluated in groups of ten mice by monitoring the tumour size of subcutaneous IGROV1 tumours. The average number of DOTA ligands per antibody was 2.5 and maximum specific activities of 600 MBq/mg were achieved under identical radiolabelling conditions. RICs were stable in human plasma for at least 48 h. {sup 177}Lu- and {sup 161}Tb-DOTA-chCE7 showed high tumour uptake (37.8-39.0 %IA/g, 144 h p.i.) with low levels in off-target organs. SPECT/CT images confirmed the biodistribution data. {sup 161}Tb-labelled chCE7 revealed a higher radiotoxicity in nude mice (MTD: 10 MBq) than the {sup 177}Lu-labelled counterpart (MTD: 12 MBq). In a comparative therapy study with equitoxic doses, tumour growth inhibition was better by 82.6 % for the {sup 161}Tb-DOTA-chCE7 than the {sup 177}Lu-DOTA-chCE7 RIT. Our study is the first to show that anti-L1CAM {sup 161}Tb RIT is more effective compared to {sup 177}Lu RIT in ovarian cancer xenografts

  5. Handling and Separation of Short-Lived Radioisotopes from Research Reactors; Manipulation et Separation des Radioisotopes a Courte Periode Produits dans des Reacteurs de Recherche; ПОЛУЧЕНИЕ И ОТДЕЛЕНИЕ КОРОТКОЖИВУЩИХ ИЗОТОПОВ В ИССЛЕДОВАТЕЛЬСКИХ РЕАКТОРАХ; Manipulacion y Separacion de Radioisotopos de Periodo Corto Obtenidos en Reactores de Investigacion

    Energy Technology Data Exchange (ETDEWEB)

    Meinke, W. W. [University of Michigan, Ann Arbor, MI (United States)

    1963-03-15

    amal'gamnyj obmen. Pojavlenie takih metodik, kak jelektromigracija i hromatografija na bumage, tonkoslojnaja hromatografija, gazovaja hromatografija, selektivnaja destilljacija, selektivnoe vosstanovlenie i t.d. takzhe rasshirjaet vozmozhnosti sposoba otdelenija, kotorye dolzhny byt' izucheny. Mestnyj issledovatel'skij reaktor, bud' to v universitete v Soedinennyh Shtatah idi v kakoj- libo razvivajushhejsja strane mira, otkryvaet, takim obrazom, novuju jeru v ispol'zovanii vozmozhnostej mechennyh atomov. (author)

  6. Renal Scintiscanning with Hg{sup 209}-Neohydrin in Urologic Diseases; Scintigraphy du Rein dans les Maladies des Voies Urin Aires au Moyen de Neohydrine Marquee avec {sup 203}Hg; Stsintillyatsionnoe skennirovanie pochek s pomoshch'yu neogidrina,mechennogo Rtut'yu-203, pri urologicheskikh zabolevaniyakh; Exploracion Centelleografica del Rinon con Neohydrina - {sup 203}hg en las Afecciones Urologicas

    Energy Technology Data Exchange (ETDEWEB)

    Bollini, V.; Tori, G. [Radiology Institute of the University of Bologna (Italy)

    1964-10-15

    determinar una disminucion de la funcion renal y a diferenciar los casos unilaterales de los bilaterales. Asi, la centelleografia del rinon constituye al parecer una tecnica clinica de gran utilidad, especialmente si se combina con el examen radiologico por medios tradicionales (urogtafia, pielografia ascendente, retroneumoperitoneo, tomografia, aorto- grafia, etc.). (author) [Russian] Dlja scintilljacionnogo skenirovanija pochek ispol'zovalsja neogidrin, mechennyj rtut'ju-203. Byl primenen jaderncj Chikagskij izotopnyj skenner tipa 1700 s kristallom 5 h 5 sm i kollimator ''Hanikoum'' s fokusnym rasstojaniem 7 sm. Obychno scintigrammy registrirujutsja odnovremenno na bumage i na fotoplenke. Neogidrin, mechennyj rtut'ju-203, primenjaetsja obychno v dozah 120 - 160 mkkjuri (okolo 2 mkkjuri/kg). Skennirovanie nachinajut spustja 2 chasa posle in{sup e}kcii i prodolzhajut 40 - 50 minut. Selektivnoe skoplenie mechenogo neogidrina v korkovom sloe pochek daet vozmozhnost' poluchit' graficheskoe izobrazhenie obeih pochek i opredelit' ih polozhenie, orientaciju i formu, a takzhe gomogennost' aktivno funkcionirujushhej parenhimy. V nekotoryh sluchajah byli provedeny avtoradiograficheskie issledovanija porazhennyh pochek posle hirurgicheskogo udalenija. S pomoshh'ju takogo metoda mozhno diagnoscirovat' kak vrozhdennye, tak i priobretennye anomalii polozhenija i orientacii. Chto kasaetsja formy, to granicy pochek mozhno opredelit' tem tochnee, chem luchshe funkcioniruet pochka. Takie tehnicheskie aspekty, kak shirina kristalla, tip kollimatora (fokal'naja ploskost' kotorogo dolzhna prohodit' cherez srednjuju poperechnuju ploskost' pochek) i doza, kotoraja ne dolzhna byt' slishkom vysokoj ili slishkom maloj, sostavljajut sushhestvennoe uslovie dlja pravil'nogo graficheskogo vosproizvedenija ochertanij pochek. Narushenie dejatel'nosti kanal'cev v parenhime opredeljaetsja blagodarja narusheniju pogloshhenija radioaktivnosti. Polozhenie, razmery i forma takih defektov pogloshhenija

  7. Thermal Annealing of Paramagnetic Defects Induced by Gamma Irradiation in (NH{sub 4}){sub 2}SO{sub 4} and (ND{sub 4}){sub 2}SO{sub 4} Single Crystals: Experimental Verification of the Theory of Fletcher and Brown; Recuit Thermique des Defauts Paramagnetiques Induits par Irradiation Gamma dans des Monocristaux de (NH{sub 4}){sub 2}SO{sub 4} et (ND{sub 4}){sub 2}SO{sub 4}: Verification Experimentale de la Theorie de Fletcher et Brown; 0422 0415 0420 041c 0414 ; Regeneracion Termica de los Defectos Paramagneticos Inducidos por Irradiacion Gamma en Monocristales de (NH{sub 4}){sub 2}SO{sub 4} y (ND{sub 4}){sub 2}SO{sub 4}: Verificacion Experimental de la Teoria de Fletcher y Brown

    Energy Technology Data Exchange (ETDEWEB)

    Calusaru, A.; Barbur, I.; Ursu, I. [Institut de Physique Atomique, Bucarest (Romania); Universite ' Babes' , Cluj (Romania)

    1965-04-15

    kinetika s edinym plato, sootvetstvujushhim obshhej rekombinacii radikalov. Dlja kazhdoj izotermy predstavljaetsja vozmozhnym sostavit' sootvetstvujushhee uravnenie, ispol'zuja pri jetom funkciju oshibok, vyvedennuju Fletcherom i Braunom pri rassmotrenii modeli i rekombinacii par, vnachale korrelirovannyh, a zatem vydelennyh v sootvetstvii s processom besporjadochnogo dvizhenija. Posle ispravlenija jetoj funkcii s uchetom kojefficienta q dannaja funkcija byla privedena v sootvetstvie s opytom. Sostavnaja krivaja otzhiga ochen' horosho otrazhaet funkciju ispravlennyh oshibok. Pri primenenii fenomenologicheskogo metoda Fletchera i Brauna dlja rascheta jenergii aktivacii bylo najdeno znachenie 1,594 jev, sootvetstvujushhee pervomu radikalu v (NH{sub 4}){sub 2}SO{sub 4}. Ispol'zuja izmenenie kojefficienta diffuzii'v zavisimosti ot temperatury, dlja toj zhe jenergii aktivacii bylo ustanovleno znachenie v 1,592 jev. S pomoshh'ju metoda Vand-Primak bylo najdeno znachenie v 1,45 jev, kotoroe javljaetsja men'shim po sravneniju s dvumja predydushhimi. V zakljuchenie otmechaetsja, chto model' rekombinacii par, korrelirovannyh v sootvetstvii s processom besporjadochnogo dvizhenija, primenima v forme, privedennoj v teorii, kogda imeetsja dovol'no slaboe vzaimodejstvie mezhdu obrazovavshimisja vidami i reshetkoj; takim putem pervonachal'no korrelirovannye pary mogut byt' vydeleny. (author)

  8. An Assessment of those Metabolites Considered to be of Value in the Diagnosis of Exposure to Radiation; Evaluation des Metabolites Consideres Comme Utiles dans le Diagnostic des Expositions aux Rayonnements; 041e 0426 0414 ; Evaluacion de los Metabolitos Considerados Utiles para Diagnosticar la Exposicion a las Radiaciones

    Energy Technology Data Exchange (ETDEWEB)

    Smith, H.; Bates, T. H. [United Kingdom Atomic Energy Authority, Chapelcross, Annan, Scotland (United Kingdom)

    1965-06-15

    -oblucheniju v terapevticheskih celjah. Jeti pacienty poluchili dozy do 5000 r za period ot treh do pjati nedel'. Vydelenie s mochej kreatina, kreatinina, obshhego {alpha}-amidnogo azota, {beta} aminoizom asljanoj kisloty, pirolle-2- karbonovoj kisloty, 5-oksiindoleaciticheskoj kisloty i indoksil-sul'fata soprovozhdalis' kolichestvenno v techenie vsego hoda lechenija. Nikto iz pacientov ne podvergalsja oblucheniju vsego organizma, no ochevidno, chto izmenenija v metabolicheskoj funkcii v rezul'tate povrezhdenija, vyzvannogo izlucheniem, mozhet skazat'sja na mochevom vydelenii. Obsuzhdaetsja biohimicheskaja ocenka i interpretacija jetih obrazcov vydelenija v otnoshenii toj chasti obluchennogo organizma, no na jetoj stadii issledovanija delaetsja vyvod, chto kolichestvennaja ocenka biologicheskogo povrezhdenija ne vozmozhna. Odnako takie opyty mogut byt' poleznymi v kachestve rukovodstva dlja klinicista otnositel'no jetogo vida terapii. Predvaritel'nye opyty na osnove izmenenij v nekotoryh metabolitah plazmy u krys, obluchennyh edinymi subletal'nymi dozami rentgenovskogo obluchenija, dostojny jekstrapoljacii dlja izuchenija chelovecheskogo organizma. Izmerjalis' koncentracii plazmy 5-oksitrip- taminovoj mochevoj kisloty, SGOT, SGPT, frakcii globulina proteina, fosfokinaza kreatina, aminopeptidaza lejcina, aminopeptidaza lizila, kalikreina, kallidina, cinka i marganca. Nabljudalis vse zhe znachitel'nye kolichestvennye izmenenija v urovnjah plazmy mochevoj kisloty, aminopeptidaza lejcina, aminopeptidaza lizila i marganca posle obluchenija. O b suzhdaetsja znachenie jetih dannyh. Vnimanie koncentriruetsja na prostyh i bystryh metodah. (author)

  9. Control Methods Used in the Department of Metallurgy for Structure and Fuel Elements; Methodes de Controle Utilisees au Departement de Metallurgie pour les Elements de Structure et les Elements Combustibles; Metody kontrolya struktury toplivnykh ehlementov v departamente metallurgii; Metodos de Control Utilizados en el Departamento de Metalurgia para los Elementos Estructurales y Combustibles

    Energy Technology Data Exchange (ETDEWEB)

    Destribats, Marie-Therese; Allain, C.; Prot, A.; Thome, P. [Centre d' Etudes Nucleaires de Saclay (France)

    1965-09-15

    metodos se han desarrollado con miras a su utilizacion industrial. Algunos de ellos se aplican ya corrientemente durante la fabricacion; otros se utilizaran proximamente y el resto es susceptible de aplicacion a mas largo plazo. (author) [Russian] Nachatoe v KAJe izuchenie razlichnyh tipov reaktorov privelo k ispol'zovaniju i razrabotke mnogih metodov nedestruktivnogo kontrolja razlichnyh materialov, v chastnosti radiografii, gammagrafii, ul'trazvukovyh voln i metoda tokov Fuko. Nizhe govoritsja o kontrole v processe stroitel'stva reaktorov sistemy EDF (grafit- gaz), EL4 (tjazhelaja voda) i izgotovlenija sovmestno prokatannyh jelementov. Vydeleny nekotorye harakternee momenty jetih razlichnyh metodov, chast' kotoryh horosho izvestna. Sistema EDF: izmerenie tolshhiny stenok trub iz urana ili iz uranovogo splava ul'trazvukom; vyjavlenie polostej v jetih trubkah s pomosh'ju gammagrafii; kontrol' za termicheskoj obrabotkoj ul'trazvukom jetih trub; izuchenie defektov (vkraplenija, treshhiny) ul'trazvukom v slitkah i zagotovkah obolochek iz MgZr; kontrol' za germetichnost'ju toplivnyh jelementov s pomoshh'ju gelija. Sistema EL 4: izmerenie tolshiny stenok silovyh trub i napravljajushhih trub iz cirkal- loja s pomoshh'ju ul'trazvuka i tokov Fuko; proverka s pomoshh'ju ul'trazvuka trub iz cirkal- loja, rasschitannyh na davlenie, i trubchatogo pokrytija iz nerzhavejushhej stali; vakuumnaja radiografija obolochek iz Be; kontrol' germetichnosti sterzhnej s pomoshh'ju gelija. Sovmestno prokatannye jelementy: izmerenie tolshhiny pokrytija pul'sirujushhimi tokami Fuko; vyjavlenie polozhenija serdechnika po otnosheniju k trubam i plastinkam s pomoshh'ju radiografii, scheta gamma-chastic i pul'sirujushhih tokov Fuko; kontrol' za gomogennost'ju topliva metodom scheta gamma-chastic; obnaruzhenie treshhin v slitkah iz ZrU s pomoshh'ju ul'trazvuka i gammagrafii; vyjavlenie otsloennyh uchastkov plastinok s pomoshh'ju ul'trazvuka, pul'sirujushhih tokov Fuko, a takzhe izmerenie udel

  10. C595 antibody: A potential vector for targeted alpha therapy

    International Nuclear Information System (INIS)

    Perkins, A.C.; Allen, B.J.

    2005-01-01

    Full text: Mucins are high molecular-weight heavily glycosylated glycoproteins with many oligosaccharide side-chains, linked to a protein backbone called apomucin. A total of 19 different mucin genes (MUC1-MUC4, MUC5B, MUC5AC, MUC6-MUC18) have been identified to date. Mucins are present on the surface of most epithelial cells and play a role in their protection and lubrication. In cancer cells the mucin molecule becomes altered, thus representing an important target for diagnosis and therapy. Urinary epithelial mucin1 (MUC1) is found to be frequently up-regulated and abnormally glycosylated in a number of common malignancies, including breast, bladder, colon, ovarian and gastric cancer. The monoclonal antibody C595 is an IgG3 murine MAb raised against the protein core of human MUC1. Epitope mapping has shown that C595 recognizes a tetrapeptide motif (RPAP) within the protein core of MUC1 mucin that contains a large domain of multiples of a highly conserved 20-amino-acid-repeat sequence (PDTRPAPGSTAPPAHGVTSA). This antibody has previously been radiolabelled with 99m Tc and 111 In and used for imaging a range of tumour types including ovary, breast and bladder. The antibody has also been radiolabelled with 67 Cu and 188 Re for the therapy of superficial bladder cancer. More recently we have investigated the pre-clinical use of the C595 antibody for targeted alpha therapy using 213 Bi which emits alpha particles with high linear energy transfer (LET), short range (80 m) radiation and has a short physical half-life of 45.6 minutes. Alpha particles are some 7300 times heavier than beta particles and in theory, following binding of an alpha immunocongugates to the target, a large fraction of the alpha particle energy is delivered to cancer cells, with minimal concomitant radiation of normal tissues. 213 Bi was produced from the 225 Ac/ 213 Bi generator. For antibody conjugation the chelator, cyclic diethylenetriaminepentacetic acid anhydride (DTPA) was used. Initial

  11. Some Techniques for Isolating and Using Short-Lived Radioisotopes; Quelques Methodes d'Isolement et d'Utilisation des Radioisotopes a Courte Periode; НЕКОТОРЫЕ МЕТОДЫ ПОЛУЧЕНИЯ И ИСПОЛЬЗОВАНИЯ КОРОТКОЖИВУЩИХ ИЗОТОПОВ; Algunas Tecnicas de Aislamiento y Empleo de Radioisotopos de Periodo Corto

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, F.; Kraus, K. A. [Chemstry Division, Oak Ridge National Laboratory, Oak Ridge, TN (United States)

    1963-03-15

    izotopov, poluchaemyh pri nejtronnom obluchenii materialov, v tom chisle rasshhepljajushhihsja jelementov. Poslednie, bezuslovno, javljajutsja nadezhnymi istochnikami rjada poleznyh ksrotko- zhivushhih izotopov, naprimer, Mo{sup 99} i Te{sup 132}. Opisyvajutsja yetody bystrogo vydelenija jetih izotopov s pomoshh'ju ionnogo obmena, a takzhe metody otdelenija korotkozhivushhih dochernih izotopov ot ishodnyh dolgozhivushhih izotopov s pomoshh'ju special'noj tehniki vydelenija (''doenija'') kogda ishodnyj izotop bystro adsorbiruetsja na organicheskih i neorganicheskih ionoobmennyh materialah. Obsuzhdajutsja takzhe tipichnye sluchai, naprimer, vydelenie In{sup 113} s periodom poluraspada 1,7 chasa (iz Sn{sup 113}) i Va{sup 137} s periodom poluraspada 2,6 min (iz Sv{sup 137}). Opisyvajutsja dva vida primenenija korotkozhivushhih indikatorov v himicheskih issledovanijah. Vo- pervyh, metod 'uplotnennogo sloja' dlja bystrogo izmerenija rastvorimosti umerenno rastvorimyh solej, mechennyh indikatorami. Privodjatsja nekotorye novye dannye, poluchennye s pomoshh'ju jetogo metoda, v otnoshenii rastvorimosti LaF{sub 3} v rastvorah HCl i HClO{sub 4}. Vo-vtoryh, opisan bystryj metod izmerenija kojefficientov diffuzii v zhidkih sistemah. Tonkie poristye farforovye fritty nasyshhajutsja rastvorom, soderzhashhim radioizotop, zatem bystro promyvajutsja rastvorom, ne soderzhashhim indikatory. Kojefficienty diffuzii mogut byt' rasschitany iz umen'shenija skorosti scheta fritta s techeniem vremeni posle sravnenija s materialom s izvestnoj skorost'ju diffuzii. Blagodarja korotkomu sroku diffuzii, s pomoshh'ju jetogo metoda izmerenija mogut byt' provedeny za znachitel'no bolee korotkoe vremja, chem s pomoshh'ju obychnyh metodik, naprimer, s pomoshh'ju kamery s diafragmoj ili kapilljarnyh trubok. (author)

  12. Automatic Sample and Data Processing in Studies of Calcium Metabolism in Rats; Traitement Automatique des Echantillons et des Donnees dans l'Etude du Metabolisme Calcique chez le Rat; Avtomaticheskaya obrabotka obraztsov i dannykh pri izuchenii obmena kal'tsiya u krysy; Tratamiento Automatico de las Muestras y de los Datos en el Estudio del Metabousmo del Calcio en la Rata

    Energy Technology Data Exchange (ETDEWEB)

    Onkelinx, C.; Richelle, L. J.; Debras, J. [Universite de Liege (Belgium)

    1965-10-15

    , s odnoj storony, izuchenija jevoljucii indikatornoj dozy kal'cija-45, vvedennoj vnutrivenno, a s drugoj -izmerenija himicheskogo i radiohimicheskogo balansa. Sochetanie jetih dvuh tipov informacii i ih matematicheskaja obrabotka vedet k resheniju voprosa o sozdanii obshhej modeli obmena kal'cija, chto daet vozmozhnost' znat' kolichestvo obmenivaemyh kletok i velichinu razlichnyh faktorov, takih kak pogloshhenie v kishechnike, vydelenie iz pochek i kishechnika, otlozhenie kal'cija v kostjah i vyhod kal'cija iz kostej. Nashi raboty byli oblegcheny primeneniem avtomaticheskih metodov izmerenija obrazcov i obrabotki dannyh, kotorye i sostavljajut predmet nastojashhego doklada. Obrabotka obrazcov. Izmerenija radioaktivnosti proizvodili na obrazcah plazmy nebol'shogo ob'ema (20 - 40 {lambda}), kotorye brali povtorno iz prob mochi i fekalij, vzjatyh v opredelennoe vremja. Izmerenie aktivnosti provodili na schetchike antisovpadenij so olabym fonovym shumom, vkljuchajushhim avtomaticheskoe ustrojstvo dlja otbora prob i jelektronnuju ustanovku, izmerenija kotoroj registrirovalis' pechatajushhim ustrojstvom. Obsuzhdajutsja original'nye metody podgotovki obrazcov i ih izmerenija, v chastnosti statisticheskie uslovija scheta, vyverennye na vychislitel'noj mashine pri kazhdom izmerenii. Obrabotka dannyh. Proizvoditsja na jelektronnoj vychislitel'noj mashine IBM 7040, kotoroj zadajut raschetnuju programmu i ispol'zujut nabor neobrabotannyh dannyh ob jeksperimente v vide perforirovannyh kartochek na kazhdoe zhivotnoe otdel'no. Dannye obrabatyvajutsja v tri jetapa: 1) preobrazovanie neobrabotannyh dannyh i raschet standartnogo otklonenija izmerenij kazhdogo obrazca; 2) analiz krivoj udel'noj radioaktivnosti plazmy v zavisimosti ot vremeni i raschet ego matjomaticheskogo vyrazhenija; vyverka na tochnost' teoreticheskoj krivoj s pomoshh'ju jeksperimental'nyh izmerenij; 3) reshenie polnoj modeli po raschetu razlichnyh parametrov. Poluchennye rezul'taty byli otpechatany obychnym

  13. Use of Radioactive Tracers in the Study of Insect-Plant Relationships; Emploi des radioindicateurs dans l'etude des relations insecte-plante; Ispol'zovanie radioaktivnykh indikatorov dlya izucheniya vzaimnoj svyazi mezhdu nasekomymi ch rasteniyami; Empleo de marcadores radiactivos para estudiar las relaciones insecto-planta

    Energy Technology Data Exchange (ETDEWEB)

    Crossley, Jr., D. A. [Radiation Ecology Section, Health Physics Division, Oak Ridge National Laboratory, Oak Ridge, TN (United States)

    1963-09-15

    habian pasaco la hibernacion de los adultos nuevos, porque la eliminacion del cesio en los primeros era mas rapida. En los estudios sobre poblaciones formadas por varias especies, la relacion entre el tamano del insecto y el indice de eliminacion sirvio para calcular el periodo medio biologico para la eliminacion del radiocesio por insectos harbivoros en una zona tratada con {sup 137}Ce. Este periodo medio y los datos sobre las masas biologicas vegetales e insectiles y sobre las concentraciones de radiocesio han permitido calcular el consumo de vegetales de una poblacion entera de insectos. Del mismo modo, se ha podido calcular el consumo de insectos de los artropodos depredadores basandose en las concentraciones estacionarias de radiocesio en los depredadores y en las victimas, las masas biologicas y el indice medio de eliminacion. (author) [Russian] Pri bolee rannem ispol'zovanii radioaktivnykh indikatorov v ehkologicheskikh issledovaniyakh nasekomykh-vreditelej ikh rasseyaniya i migratsii izuchalis' pri pomoshchi radioizotopov, kotorymi markirovalis' otdel'nye nasekomye. V poslednee vremya poluchilo rasprostranenie ispol'zovanie radioizotopov dlya izucheniya biologicheskoj assotsiatsii nasekomykh i rastenij, a takkhe khishchnykh nasekomykh i ikh dobychi, iskhodya iz opredeleniya potrebleniya imi pishchi. Biologicheskoe vydelenie radioizotopov, kotoroe meshaet izucheniyu rasseyaniya nasekomykh, ispol'zuetsya v nastoyashchee vremya dlya izmereniya kolichestva potrebleniya pishchi. Kak v polevykh issledovaniyakh, tak i v laboratornykh ehksperimentakh nasekomym daetsya vozmozhnost' dostich' v protsesse pitaniya sostoyaniya ustojchivoj kontsentratsii radioizotopov. V ehtikh usloviyakh temp pogloshcheniya dannogo radioizotopa raven tempu ego vydeleniya: (temp pogloshcheniya) = (velichine ustojchivogo sostoyaniya) x (skorost' poteri); Izmereniya tempov vydeleniya (biologicheskogo poluraspada) pozvolyayut perevodit' sostoyaniya ustojchivoj kontsentratsii v funktsii tempov

  14. Interesting Developments in UO{sub 2} Technology; Progres interessants dans la technologie du bioxyde d'uranium; Interesnye usovershenstvovaniya tekhnologii UO{sub 2}; Recientes progresos en la tecnologia del UO{sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Robertson, J. A.L. [Atomic Energy of Canada Ltd., Chalk River, Ontario (Canada)

    1963-11-15

    vydelenie iz UO{sub 2} gazov, yavlyayushchikhsya produktami deleniya. V chastnosti, uvelichenie oblucheniya s 10{sup 15} do 10{sup 18} delenij/cm{sup 2} mozhet snizit' ochevidnye skorosti diffuzii dlya ksenona v UO{sub 2} pri posleduyushchikh obzhigakh na koehffitsient 10{sup 3}. Gaz, po-vidimomu, uderzhivaetsya v mel'chajshikh lovushkakh, chast' iz kotorykh sushchestvuet v iskhodnom materiale, a chast' obrazuetsya v rezul'tate radiatsionnogo povrezhdeniya. Tshchatel'nyj analiz pokazal sushchestvovanie medlennoj utechki iz lovushek, chto, veroyatno, ob''yasnyaetsya ogranichennoj rastvorimost'yu ksenona v UO{sub 2}. Vozmozhnost' osushchestvleniya izmerenij v reaktore otkryvaet novuyu fazu eshche bolee vazhnykh ehksperimentov. Oni pokazhut, imeyutsya li kakie-libo potentsial'nye ehkonomicheskie preimushchestva v novykh formakh topliva. V to zhe vremya budut prodolzhat'sya nastojchivye razrabotki spechenoj UO{sub 2} v prostoj geometrii sterzhnya. (author)

  15. The Use of Research Reactors and Short-Lived Isotopes in the Study of Nuclear-Reactor Fuel Materials; Emploi de Reacteurs de Recherche et de Radioisotopes de Courte Periode dans l'Etude des Combustibles pour Reacteurs Nucleaires; ИСПОЛЬЗОВАНИЕ ИССЛЕДОВАТЕЛЬСКИХ РЕАКТОРОВ И КОРОТКОЖИВУЩИХ ИЗОТОПОВ ПРИ ИЗУЧЕНИИ ТОПЛИВНЫХ МАТЕРИАЛОВ ДЛЯ ЯДЕРННХ РЕАКТОРОВ; Empleo de Reactores de Investigacion y de Isotopos de Periodo Corto en el Estudio de Combustibles Nucleares

    Energy Technology Data Exchange (ETDEWEB)

    Elleman, T. S.; Townley, C. W.; Sunderman, D. N. [Battelle Memorial Institute, Columbus, OH (United States)

    1963-03-15

    ) adsorbirujutsja v ohlazhdaemyh lovushkah iz drevesnogo uglja, razdeljajutsja jeljuirovaniem na frakcii joda, kriptona i ksenona putem hromatografii ka kolonke i analizirujutsja pri pomoshhi gamma-luchevoj spektrometrii. Vysvobozhdaemye obrazcom neletuchie produkty delenija otlagajutsja na sosednej lovushke iz metallicheskoj fol'gi, kotoraja mozhet byt' vynuta v ljuboj moment obluchenija dlja analiza. Vysvobozhdenie produktov delenija, nabljudaemoe dlja razlichnyh uslovij obluchenija, mozhet libo zaviset' ot koncentracii, libo ne zaviset' ot nee i mozhet pokazyvat' predpochtitel'noe vydelenie opredelennyh jelementov, bystroe vysvobozhdenie produktov delenija pri izmenenii temperatury i vysvobozhdenie gazoobraznyh produktov delenija posle ostanovki reaktora. Ispol'zovanie jetogo tehnologicheskogo metoda daet vozmozhnost' poluchit' osnovnuju informaciju otnositel'no povedenija materialov dlja prototipov topliva bez neobhodimosti ispol'zovanija krupnyh ispytatel'nyh reaktorov ili zhe bez ustrojstva kamer dlja obrashhenija s vysokoaktivnymi obrazcami. (author)

  16. Distribution and removal of transuranic elements and cerium deposited by the inhalation route; Distribution et elimination des transuraniens et du cerium deposes par l'intermediaire des voies respiratoires; Raspredelenie transuranovykh ehlementov i tseriya, otkladyvayushchikhsya v rezul'tate vdykhaniya i ikh udalenie; Distribucion y eliminacion de elementos transuranicos y de cerio depositados por inhalacion

    Energy Technology Data Exchange (ETDEWEB)

    Bair, W. J.; Tombropoulos, E. G.; Park, J. F. [Hanford Atomic Products Operation, General Electric Company, Richland, WA (United States)

    1963-02-15

    , parasimpatominmeticos, parasiinpatoliticos y antihistamfnicos. El agente de quelacion, acido dietilentriaminopentaacetico.administ'rado en forma de aerosol o por via intraperitoneal elimina rapidamente el {sup 144}Ce-{sup 144}Pr de los pulmones y del organismo por excrecion urinaria. Un mes despues de ser expuestos a la accion del {sup 144}CeO{sub 2}, las ratas y perros tratados retienen una cantidad de {sup 144}Ce-{sup 144}Pr inferior al 10% de la retenida por los animales no tratados. (author) [Russian] Raspredelenie v tkanyakh i vydelenie vdykhaemykh radioaktivnykh izotopov menyaetsya vmeste s khimicheskoj formoj i razmerom chastits aehrozolej. U sobak cherez tridtsat' dnej posle vdykhaniya 70% nitrata plutoniya bylo obnaruzheno v legkikh, 10% - v, pecheni i 15% - v kostyakh skeleta. Posle vdykhaniya aehrozolya P{sup 239} O{sub 2} s vyschityvaemym srednim diametrom chastits (VSD), ravnym 0,12 mikron, 71% ehtogo veshchestva v organizme bylo skontsentrirovano v legkikh, 3% - v bronkhial'nykh limfaticheskikh uzlakh, 4,4% - v myshtsakh, 1,3% - v kostyakh skeleta i 20% bylo ravnomerno raspredeleno v ostal'nykh tkanyakh. Posle vdykhaniya aehrozolya P{sup 239} O{sub 2} s VSD chastits v intervale 0,3 - 0,6 mikron v legkikh soderzhalos' 98% veshchestva, v bronkhial'nykh limfaticheskikh uzlakh - okolo 1% i v ostal'nykh tkanyakh - 1%. Ehti dannye i issledovaniya mochi i isprazhnenij ukazyvayut na otnositel'nuyu vazhnost' trekh putej, po kotorym vdykhaemye radioaktivnye izotopy vyvodilis' iz legkikh, a imenno cherez trakheyu v rezul'tate dvizheniya resnichen s posledueshchem vydeleniem s isprazhneniyami, cherez al'veolyarnuyu membranu i pereraspredelenie v drugikh lgkanyakh s postepennym vydeleniem s mochoj i, nakonets, putem peremeshcheniya v bronkhial'nye limfaticheskie uzly, kotorye nakoplyayut vdykhaemye nerastvorimye veshchestva. Byli oprobovany terapevticheskie sredstva, kotorye, kak mozhno bylo ozhidat', povyshayut ochishchenie legkikh ot radioaktivnykh izotopov takimi putyami, pri

  17. Interpretation of Bioassay Data; Interpretation des Donnees de l'Analyse d'Echantillons Biologiques; Interpretatsiya dannykh biologicheskikh issledovanij; Interpretacion de Datos Obtenidos por Bioanalisis

    Energy Technology Data Exchange (ETDEWEB)

    Dolphin, G. W.; Jackson, S. [Health Physics and Medical Division, Atomic Energy Research Establishment, Harwell, Berkshire (United Kingdom)

    1964-10-15

    a un nivel determinado de la carga corporal. Es esencial que las mediciones para la vigilancia regular se efectuen con la maxima precision y se registren minuciosamente. Tales mediciones pueden utilizarse mucho tiempo despues para evaluar la carga corporal cronica. Se resumen los datos disponibles acerca del metabolismo humano y de la excrecion por via urinaria del tritio, cesio, uranio, estroncio, radio y plutonio. (author) [Russian] Dlja ocenki dozy obluchenija kriticheskogo organa, svjazannoj s vnutrennim zarazheniem radioizotopami, neobhodimo opredeljat' kolichestva izotopov v organizme. Esli radioizotop javljaetsja istochnikom gamma- ili rentgenovyh luchej ili beta-izluchenija, vyzyvajushhego sootvetstvujushhee tormoznoe izluchenie, prjamye izmerenija soderzhanija ego b organizme mogut proizvodit'sja s pomoshh'ju ustanovki dlja izmerenija radioaktivnosti vsego organizma. Kogda zhe sootvetstvujushhie izluchenija otsutstvujut, opredelenija-proizvodjatsja s pomoshh'ju izmerenija kolichestva radioizotopov v vydelenijah, krovi, vdyhaemom vozduhe ili mazkah, vzjatyh iz nosovoj ili rotovoj polosti. Provodilos' izuchenie vydelenija radioizotopov v moche kak pokazatelja vnutrennego zarazhenija. Analiz mochi javljaetsja naibolee shiroko ispol'zuemoj formoj biologicheskogo analiza. .Ochen' ver'eznym nedostatkom vse eshe javljaetsja maloe kolichestvo dannyh ob obmene radioizotopov, i neobhodimy dal'nejshie issledovanija. V dannom obzore dlja klassifikacii razlichnyh vidov obmena raznoobraznyh izotopov ispol'zovany tri bol'shie grupp'k Pervaja gruppa vkljuchaet*te radioizotopy, kotorye dovol'no odnorodno raspredeljajutsja v organizme. Vtoraja gruppa soderzhit te, kotorye koncentrirujutsja glavnym obrazom v odnom ili bolee organah tela. Tret'ja gruppa fakticheski javljaetsja osobo vazhnoj podgruppoj vtoroj gruppy i soderzhit otkladyvajushhiesja v kostjah izotopy. Vydelenie s mochoj i osobenno ego svjaz' s dozoj, poluchaemoj kriticheskimi tkanjami, otchetlivo razlichaetsja

  18. Electrolyte Concentrations of Intra- and Extracellular Compartments in Some Internal Diseases; Concentration des Electrolytes dans les Compartiments Intra- et Extracellulares, dans Certaines Maladies Internes; ВНУТРИКЛЕТОЧНАЯ И ВНЕКЛЕТОЧНАЯ КОНЦЕНТРАЦИЯ ЭЛЕКТРОЛИТОВ ПРИ НЕКОТОРЫХ ВНУТРЕННИХ ЗАБОЛЕВАНИЯХ; Concentraciones de Electrolitos en Comp Artimientos Intra y Extracelulares en Algunas Enfermedades Internas

    Energy Technology Data Exchange (ETDEWEB)

    Itahara, K.; Ito, K.; Tominaga, T.; Jimbo, T.; Sato, T. [Tohoku University, Sendai (Japan)

    1963-03-15

    radioaktivnogo kalija K{sup 42} u bol'nyh s jessencial'noj gipertoniej, pervichnym al'dosteroniz- mom i periodicheskim paralichom. Soderzhanie vnekletochnogo Nae (v millijekvivalentah na 1 kg vesa tela) u desjati pacientov, bol'nyh gipertoniej, sostavljalo v srednem 45,2 (v norme 39,5), i srednjaja velichina vnekletochnogo kalija (K{sub e}) pri 14 opredelenijah sostavila 32,5 (v korme 42,7). Sootnoshenie vnutrikletochnyh kon- cengracij K/Na ravnjalos' 1,8 (v norme 2,9), a vnutri- i vnekletochnoj koncentracii kalija sostavilo v srednem 26,6 (v norme 28,4). Pojetomu schitalos', chto u jetih pacientov kalij vydeljalsja s mochoj vsledstvie uvelichenija klirensa kalija i soderzhanie ego v organizme umen'shalos'. Iz dvuh bol'nyh s pervichnym al'dosteronijemom u odnogo s pristupami paralicha kojefficient koncentracii kalija byl povyshen (37,2), a u drugogo, bez pristupa, byl normalen (29,5). U dvuh drugih pacientov s nenasledstvennym periodicheskim paralichom jetot kojefficient kon- cek' racii vne- i vnutrikletochnogo kalija sostavljal sootvetstvenno 42,8 i 48,7 vo vremja provocirovav jugo pristupa, hotja vydelenie kalija s mochoj ne uvelichivalos'. Bylo pokazano,chto transshtaeralzh- jeacija proishodila izvne vo vnutrikletochnuju zhidkost'. Kogda polnyj ili nepolnyj paralich byl vyzvan vvedeniem gljukozy i insulina u pjati iz vos'mi bol'nyh paralichom, jeto otnoshenie koncentracij sostavljalo vo vremja kazhdogo pristupa svyshe 38,0. Bylo obnaruzheno takzhe, chto rost jetoj velichiny sootvetstvoval tjazhesti paralicha. Pojetomu patagoneje paralicha, po-vidimomu, obuslovlen raznicej vnutri- i vnekletochnyh koncentracij kalija v dopolnenie k rostu potenciala pokoja myshc. V tablice, pomeshhennoj v rabote, privoditsja sostav jelektrolitov pri jetih zabolevanijah. (author)

  19. Determination of Fallout Radionuclides in Environmental Samples by Gamma-Ray Spectrometry; Mesure Spectrometrique Gamma des Radionucleides de Retombee Presents dans des Echantillons du Millieu; Opredelenie radioizotopov radioaktivnykh osadkov v probakh iz okruzhayushchej sredy pri pomoshchi spektrometrii gamma-luchej; Determinacion, por Espectrometria Gamma, de los Radionuclidos de Precipitaciones en Muestras del Medio Ambiente

    Energy Technology Data Exchange (ETDEWEB)

    Ward, G. M.; Johnson, J. E.; Wilson, D. W. [Department of Animal Science, Colorado State University, Fort Collins, CO (United States)

    1965-10-15

    vremeni na universitetskoj ferme sobrali znachitel'noe kolichestvo prob iz okruzhajushhej sredy dlja izuchenija dvizhenija cezija-137 v znachitel'noj chasti pishhevoj ce- pochki cheloveka. Vse proby imeli maluju udel'nuju aktivnost', i izmerenija proizvodili pri pomoshhi spektrometricheskogo ustrojstva dlja gamma-luchej nizkogo urovnja, sostojashhego iz kristalla NaJ (T1) diametrom 8 i tolshhinoj 4 djujma, prichem jetot kristall byl zashhishhen ot fona stal'noj kameroj s tolshhinoj stenok 5 djujmov i soedinen s 400-kanal'nym anali- zatorom amplitudy impul'sov. Otschet nabivok vozdushnyh fil'trov i krupnyh prob ( 1kg) suhogo furazha, zerna i pometa krupnogo rogatog o skota proizvodili neposredstvenno v postojannoj geometrii. Proby osadkov koncentrirovali propuskaniem ih cherez kationo- obmennye kolonki, zapolnennye doveksom-50. Radioaktivnost' moloka, mjasa i mochi pod- schityvali v bol'shih kol'ceobraznyh kontejnerah iz ljucita. V moloke, mjase i moche ob- naruzhivajutsja v chisle gamma-izluchajushhih radioizotopov lish' cezij-137, kalij-40, jod-131, barij-140 i lantan-140, poskol'ku oni javljajutsja edinstvennymi produktami delenija, po- gloshhaemymi v znachitel'nyh kolichestvah. Pomimo jetogo, drugie proby soderzhali cezij-141, cezij-144, sur'mu-125, rutenij-103, rutenij-106, cirkonij-95, niobij-95 i marganec-54. V probah, sobrannyh v 1962 i 1963 godah, pri pomoshhi'gamma-spektrometrii udalos' oprede- lenno obnaruzhit' lish' cirk{sup n}ij-95 i niobij-95 vvidu ih otnositel'nogo obilija; jeto bylo prodelano priblizitel'no za 6 mesjacev posle sbora prob. Fotopiki cezija-137, marganca-54 i sur'my-125 byli sovershenno rasplyvchatymi, a radioizotopy bolee malyh jenergij (cezij-141, cezij-144 i rutenij-103) imeli znachitel'nye komptonovskie vklady ot radio- izotopov bolee vysokih jenergij. Pri nedostatochno jasnyh fotopikah posledovatel'noe vydelenie produktov delenija iz spektrov ne javljaetsja nadezhnym. Kogda vlijanie drugih radioizotopov delaet nevozmozhnym

  20. Nuclear geophysics in prospecting for ore and coal deposits; Geophysique nucleaire et prospection des gisements de charbon et autres mineraux; Yadernaya geofizika pri razvedke rudnykh i ugol'nykh mestorozhdenij; Geofisica nuclear u prospeccion de yacimientos de carbon y otros minerales

    Energy Technology Data Exchange (ETDEWEB)

    Bulashevich, Yu P; Voskobojnikov, G M; Muzyukin, L V

    1962-01-15

    captura de neutrones termicos del boro hace posible determinar estratos boriferos en la zona del sondeo empleando los metodos E.G.N. y E.N.N. La influencia del agua se elimina mediante sondeos inversos. Este metodo, asi como otros sistemas de exploracion por activacion neutronica, han sido aplicados tambien en diversos yacimientos de cobre, manganeso, aluminio y otros minerales. La exploracion por activacion continua esta indicada cuando el periodo de semi [Russian] Na rudnykh i ugol'nykh mestorozhdeniyakh metody yadernoj geofiziki primenyayutsya glavnym obrazom pri karotazhe razvedochnykh skvazhin. Na rudnykh i ugol'nykh mestorozhdeniyakh Sovetskogo Soyuza nakhodyat shirokoe proizvodstvennoe primenenie sleduyushchie vidy radioaktivnogo ili yadernogo karotazha (RK): plotnostnoj ili gamma-gamma karotazh (GGK) s istochnikom izlucheniya Co{sup 60}, selektivnyj gamma-gamma karotazh (SGGK) s istochnikom myagkogo izlucheniya tipa S75, nejtron-nejtronnyj karotazh (NNK) i nejtronnyj gamma karotazh s Ro-Ve istochnikom nejtronov, akti- vatsionnyj, v chastnosti nepreryvnyj, karotazh s tem zhe istochnikom, a takzhe foto-nej- tronnyj karotazh s gamma-izluchatelem Sb{sup 124}. Osnovnaya zadacha RK na rudnykh mestorozhdeniyakh - vydelenie rudnykh zon v razreze skvazhin, chto sokrashchaet intervaly oprobovaniya, i orientirovochnaya otsenka soderzhaniya poleznogo komponenta in situ. Na ugol'nykh mestorozhdeniyakh RK reshaet zadachu opredeleniya glubiny zaleganiya, moshchnosti i stroeniya ugol'nykh plastov. ' Metody GGK i SGGK osnovany na registratsii rasseyannogo gamma-izlucheniya istochnika. Pri dostatochnoj zhestkosti izlucheniya istochnika i slaboj chuvstvitel'nosti indikatora intensivnost' rasseyannogo izlucheniya zavisit tol'ko ot plotnosti porody i rasstoyaniya mezhdu istochnikom i indikatorom. EHto sluchaj GGK, kotorym ugol'nye plasty vydelyayutsya po maksimumam rasseyannogo izlucheniya. V SGGK sushchestvenna registratsiya myagkoj chasti spektra rasseyannogo izlucheniya

  1. Use of Short-Lived Radioisotopes to Determine Impurities in Aluminium, Iron and Zirconium of Very High Purity; Dosages d'Elements par leurs Radioisotopes de Periodes Courtes Dans l'Analyse de Valuminium, du Fer et du Zirconium de Tres Hautes Puretes; ДОЗИРОВКА ЭЛЕМЕНТОВ С ПОМОЩЬЮ КОРОТКОЖИВУЩИХ РАДИОИЗОТОПОВ ПРИ АНАЛИЗЕ АЛХМИНИЯ, ЖЕЛЕЗА И ЦИРКОНИЯ ОЧЕНЬ ВЫСОКОЙ ЧИСТОТЫ; Determinacion Cuantitativa de Radioisotopos de Periodo Corto en los Analisis de Aluminio, Hierro y Circonio de Alta Pureza

    Energy Technology Data Exchange (ETDEWEB)

    Albert, Ph.; Deyris, M.; Deschamps, N.; Fournet, L. [Centre d' Etudes de Chimie Metallurgique, Vitry (France)

    1963-03-15

    que siguen a la irradiacion (caso del aluminio). Los autores hacen notar que sin separacion previa han logrado determinar por espectrometria {gamma} concentraciones de 0,6 * 10{sup -6}de vanadio y 2 * 10{sup -6} de aluminio en el hierro o el circonio puros irradiados durante 30 s con un flujo de 5 * 10{sup 1{sup 2}}n/cm{sup 2}s. Las separaciones antes de la irradiacion son necesarias para alcanzar sensibilidades mayores y tambien en el caso de los metales de menor pureza. En la memoria se pone de relieve la importante contribucion que aportan las determinaciones cuantitativas con ayuda de radioisotopos de periodo corto (2,4 min a 4,6 h) al conocimiento del grado de pureza de las muestras. (author) [Russian] V laboratorii professora Shodroka i Vitri my oznakomilis' s sistematicheskim analizom putem 'radioaktivacii' takih metallov ochen' vysokoj chistoty, kak Aljuminij, zhelezo, cirkonij i med', ochishhennyh pri pomoshhi metoda 'zonnoj plavki', a takzhe metallov promyshlennogo naznachenija vysokoj chistoty. K poslednim otnosjatsja ochishhennyj dvojnym jelektrolizom aljuminij, ochishhennaja jelektrolizom med', poluchennyj metodom termicheskoj dissociacii iodida cirkonij i vydelennoe v chistom vide iz karbonilovogo soedinenija zhelezo. Dlja provedenija jetih analizov my ispol'zovali obluchenie nejtronami, dejtronami, protonami i {gamma}- tonami jenergiej 30 Mjev v celjah dozirovki kisloroda, ugleroda i azota. Sistematicheskij analiz posle obluchenija nejtronami ogranichen pjat'judesjat'ju jelementami. Dejstvitel'no, nekotorye izotopy javljajutsja slishkom korotkozhivushhimi, naprimer vanadij-52 (3,7 min), hlorke (37,5 min), Jod-128 (25 min), aljuminiJ-28 (2,4 min), magnij-27 (9,5 min), titan-51 (5,8 min). V otnoshenii drugih jelementov ne predstavljaetsja vozmozhnym s dostatochnoj chuvstvitel'nost'ju i v ramkah sistematicheskogo analiza predusmotret' ih vydelenie i dozimetriju. Imenno tak obstoit delo v sluchae s kremnem-28 pri ego periode v 2,8 chasa (slaboe jeffektivnoe