Sample records for segawa hiromi fujimoto

  1. Kikuchi-fujimoto disease

    Directory of Open Access Journals (Sweden)

    Đokić Milomir


    Full Text Available Kikuchi-Fujimoto disease (KFD, also know as histiocytic necrotizing lymphadenitis, is a benign disorder characterized histologically by necrotic foci surrounded by histiocytic aggregates, and with the absence of neutrophils. KFD was recognized in Japan, where it was first described in 1972. The disease is most commonly affecting young women. The cause of the disease is unknown, and its exact pathogenesis has not yet been clarified. Many investigators have postulated viral etiology of KFD, connecting it with Epstein Barr virus, human herpes simplex virus 6 parvo B 19, but also with toxoplasmic infection. Kikuchi-Fujimoto disease is usually manifested with lymphadenopathy and high fever, and is associated with lymphopenia splenomegaly, and hepatomegaly with abnormal liver function tests arthralgia, and weight loss. The disease has the tendency of spontaneous remission, with mean duration of three months. Single recurrent episodes of KFD have been reported with many years’ pauses between the episodes. Kikuchi-Fujimoto disease may reflect systemic lupus erythematosus (SLE, and self-limited SLE-like conditions. Final diagnosis could only be established on the basis of typical morphological changes in the lymph node, and lymph node biopsy is needed for establishing the diagnosis. Lymphadenopathy in a patient with fever of the unknown origin could provide a clue to the diagnosis of lymphoma, tuberculosis, metastatic carcinoma, toxoplasmosis and infectious mononucleosis. As KFD does not have any classical clinical features and laboratory characteristics, it may lead to diagnostic confusion and erroneous treatment. We described a case of KFD, and suggested that this disease should be considered as a possible cause of fever of the unknown origin with lymphadenopathy.

  2. Kikuchi Fujimoto Disease

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    Al-Bishri Jamal


    Full Text Available In order to determine the clinical significance of Kikuchi Fujimoto Disease (histiocytic necrotizing lymhadenitis and to review the literature available on this condition, we selected the Medicine research papers in English language published between the years 1972 to 2011. Kikuchi Fujimoto Disease (KFD is an uncommon, cosmopolitan, benign and self-limiting condition with higher Japanese and Asian prevalence. Most of the sufferers of KFD are young people who seek treatment because of having acute tender cervical lymphadenopathy, low grade fever and night sweats. Coagulative necrosis with ample karyorrhetic debris in paracortical areas of the involved lymph nodes is the characteristic histologic feature of KFD. Diagnosing KFD is crucial as it can be mistaken for malignant lymphoma and SLE. KFD was put forth first time in 1972 by Dr. Masahiro Kikuchi and by Funimoto as lymphadenitis with reticular proliferation, histiocytes and abundant nuclear debris. It is a rare benign condition of lymph nodes and most of the clinicians and pathologists are unfamiliar with it. KFD is self-limiting disease (within 1 to 4 months, however, patients should be followed up regularly as it may crop up again or progress to SLE. Analgesics and antipyretics help to ameliorate the symptoms.

  3. Kikuchi-Fujimoto disease: pediatric case report

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    Eduardo Ojeda Lewis


    Full Text Available La enfermedad de Kikuchi-Fujimoto es una entidad rara que se presenta principalmente en adultos jóvenes, aunque se han descrito algunos casos en la edad pediátrica. Se caracteriza por adenopatías generalmente cervicales y fiebre. La etiología de la enfermedad permanece desconocida. Su curso es generalmente benigno y autolimitado. Tiene características histopatológicas especiales que permiten el diagnóstico diferencial con otras entidades, lo que desde el punto de vista clínico puede ser muy complicado. Presentamos el caso de una niña de nueve años y 11 meses que cursó con adenopatías y fiebre de cinco meses de evolución. Este tiempo es el más prolongado entre los casos revisados por los autores en la literatura mundial (búsqueda en PubMed y SciELO por “Kikuchi-Fujimoto Disease”, “histiocytic necrotizing lymphadenitis”. Dado que la presentación de esta enfermedad en la edad pediátrica es muy rara, estimamos pertinente su conocimiento y consideración en el diagnóstico diferencial de la fiebre de origen desconocido en niños.

  4. Kikuchi-Fujimoto disease (histiocytic necrotizing lymphadenitis)

    International Nuclear Information System (INIS)

    Escribano, J.; Ruza, M.; Gonzalez, J.; Acosta, A.


    Kikuchi-Fujimoto's disease is a rare but increasingly frequent cause of cervical adenopathy. It usually affects young women who also present fever and weight loss. ultrasonography and computed tomography of adenopathies usually show findings typical of benign disease (they are numerous, homogeneous, slightly or moderately increased in size, their normal echo structure is unchanged, they are clearly delimited and the surrounding tissues present no alterations, although in a few cases central necrosis has been described). Diagnosis is by ganglion biopsy showing typical findings. The disease is benign and self-limiting and treatment is not required. We believe that the disease should be included in the differential diagnosis of adenopathies, especially cervical adenophathies in young patients. (Author) 14 refs

  5. Kikuchi-Fujimoto Disease: A Case Report

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    Chih-Hung Lee


    Full Text Available We describe a rare but typical case of Kikuchi-Fujimoto disease (KFD. Two subcutaneous nodules appeared suddenly on the right of the neck of a 15-year-old girl. Microscopy of a surgical specimen of the larger nodule showed necrotizing lymphadenitis. Prompt treatment with mepirizole resulted in the disappearance of the smaller nodule. No recurrence was noted during 6 months of follow-up. KFD is a rare, self-limiting, necrotizing histiocytic lymphadenitis that needs to be differentiated from malignant lymphoma. Any nodal biopsy showing fragmented nuclei, necrosis, and karyorrhexis without prominent neutrophils should alert the physician to consideration of KFD, especially in a young woman presenting with cervical lymphadenopathy.

  6. Ecopoeta queer? Uma análise de "Chitô [Tito]", da poeta japonesa Hiromi Ito A queer ecopoet? An analysis of "Chitô" ["Tito"] by japanese poet Hiromi Ito

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    Keitaro Morita


    Full Text Available O conceito de natureza tem sido caracterizado por uma série de dicotomias, como natureza externa/natureza interna e ambiente natural/corpo. De uma forma geral, a crítica ambientalista japonesa tem ignorado o lado direito desses dualismos - natureza interna e corpo. Este trabalho enfoca essas dimensões suprimidas através do exame do ecopoema de Hiromi Ito "Chitô [Tito]", retirado do livro Noro to Saniwa [Noro e Saniwa], que escreveu com Chizuko Ueno. Ao falar sobre natureza interna e corpo, o presente estudo ocupa-se especialmente da sexualidade e da queeridade. Hiromi Ito é perspectivada como uma ecopoeta queer, porque em "Chitô", ao questionar implicitamente a 'naturalidade' da heterossexualidade universal, ela problematiza as fronteiras entre heterossexualidade e homossexualidade, mostra sem inibições sua significação erótica retida do estágio anal pré-edipiano em suas explorações sexuais adultas, assim como uma utopia onanista sadomasoquista (SM reservada apenas a uma mulher, e trata os homens no poema como sendo meros corpos desmembrados e órgãos sexuais objetificados; mais ainda, sua queeridade encontra outras encorporações significantes em sua recusa de se deixar cair na armadilha de identidades sexuais ou sexualidades fixas. Nesse sentido, este trabalho ilumina as dimensões esquecidas das dicotomias natureza externa/ natureza interna e ambiente natural/corpo em "Chitô".The concept of nature has been characterized by a number of dichotomies such as outer nature/inner nature and the natural environment/body. Generally speaking, Japanese environmental criticism has so far ignored the right side of such dualisms-inner nature and body. This paper focuses on these suppressed dimensions through an examination of a Hiromi Ito's queer ecopoem "Chit�� [Tito]," from the co-authored book Noro to Saniwa [Noro and Saniwa]. I give attention to sexuality, especially queerness, in inner nature and body. The paper positions Hiromi



    Dr. Gunja Jain; Dr. Mayank Gupta; Dr. Laxmikant Goyal; Dr. Jai Purohit; Dr. Sudhir Mehta


    Abstract— Kikuchi-Fujimoto disease (KFD) is a rare disease. It has a worldwide distribution with a higher prevalence in Asians. KFD is usually a self limiting disease and benign in nature. Clinically it presents as regional cervical lymphadenopathy and sometimes may presents as generalized lymphadenopathy as well. Night sweats and low grade fever may also be associated in some cases. A case of a 36 year old female had attended in SMS Hospital. She presented with fever, weight loss and tender ...

  8. Kikuchi-Fujimoto disease--an unusual mimicker?

    LENUS (Irish Health Repository)

    Scully, Diarmaid F


    We describe the case of a 27-year-old Chinese female diagnosed with Kikuchi-Fujimoto disease in Ireland. It principally occurs in Asian populations, but is being increasingly reported in non-Asian populations. This rare, benign disease may potentially be misdiagnosed as lymphoma, and has an association with the subsequent development of systemic lupus erythematosus. Clinicians and pathologists need to be aware of the clinical and histological features of this rare disorder to avoid misdiagnosis.

  9. An unusual cause of cervical lymphadenopathy: Kikuchi-Fujimoto disease

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    Mehmet Uluğ


    Full Text Available Kikuchi-Fujimoto disease (KFD, also known as histiocytic necrotizing lymphadenitis, is an uncommon clinical and pathologicalself-limited feature of benign prognosis that may mimic many other diseases diagnosed chiefly in youngadults. The etiology of the disease is unknown although several investigators postulate viral, parasitic and autoimmuneetiologies. The most common symptoms are cervical lymphadenopathy and fever. Diagnosis is usually rendered withexcisional biopsy of lymph nodes and through histopathological findings. Non-steroidal anti-inflammatory drugs areused for the treatment. In this report, two cases of KFD without any associated infectious and/or non-infectious conditionswere presented. J Microbiol Infect Dis 2012; 2(1: 21-25

  10. Kikuchi-Fujimoto disease: Clinical and laboratory characteristics and outcome

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    P S Rakesh


    Full Text Available Introduction: Kikuchi-Fujimoto disease is an uncommon disorder with worldwide distribution, characterized by fever and benign enlargement of the lymph nodes, primarily affecting young adults. Awareness about this disorder may help prevent misdiagnosis and inappropriate investigations and treatment. The objective of the study was to evaluate the clinical and laboratory characteristics of histopathologically confirmed cases of Kikuchi′s disease from a tertiary care center in southern India. Materials and Methods: Retrospective analysis of all adult patients with histopathologically confirmed Kikuchi′s disease from January 2007 to December 2011 in a 2700-bed teaching hospital in South India was done. The clinical and laboratory characteristics and outcome were analyzed. Results: There were 22 histopathologically confirmed cases of Kikuchi′s disease over the 5-year period of this study. The mean age of the subjects′ was 29.7 years (SD 8.11 and majority were women (Male: female- 1:3.4. Apart from enlarged cervical lymph nodes, prolonged fever was the most common presenting complaint (77.3%. The major laboratory features included anemia (54.5%, increased erythrocyte sedimentation rate (31.8%, elevated alanine aminotransferase (27.2% and elevated lactate dehydrogenase (LDH (31.8%. Conclusion: Even though rare, Kikuchi′s disease should be considered in the differential diagnosis of young individuals, especially women, presenting with lymphadenopathy and prolonged fever. Establishing the diagnosis histopathologically is essential to avoid inappropriate investigations and therapy.

  11. Kikuchi – Fujimoto Disease. Case report and a brief review of the literature

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    Manuel Valdebran


    Full Text Available Kikuchi Fujimoto disease (KFD was first described in Japan in 1972 almost simultaneously by Kikuchi and Fujimoto. It is a rare, self-limiting, benign form of histiocytic necrotizing lymphadenitis, which can be mistaken for tuberculosis, lymphoma or systemic lupus erythematosus. Although the pathogenesis of KFD is not fully understood, infectious and autoimmune etiologies have been proposed. It generally presents as cervical lymphadenopathy with associated systemic signs and symptoms. Definitive diagnosis requires histopathological examination of the affected lymph nodes. There are only few cases described in the literature, as far as we are aware we report the first case of KFD in the Dominican Republic.


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    Marta Alonso-Provencio


    Full Text Available This paper attempts to clarify a design process that is being used by Kazuyo Sejima and Sou Fujimoto based on the use of scale models. Two typical cases are studied and represented graphically in order to map the workflow. The results reveal that the mutual influence between team members, the continuous process of production and selection are closer to an "editing process" rather than the conventional linear design process. The architectural quality and character of the work produced by Sejima and Fujimoto can be seen as a consequence of the process itself. The process based on the use of scale models becomes an object of design, and its advantages and disadvantages are discussed in this article. This systematical study is expected to offer new ideas to practitioners on how to integrate scale models in the design process and how to enhance creativity and collaborative teamwork.

  13. An uncommon presentation of Kikuchi Fujimoto disease: a case report with literature review. (United States)

    Ranabhat, Sabin; Tiwari, Mamta; Kshetri, Jiwan; Maharjan, Sushna; Osti, Bidur Prasad


    Kikuchi-Fujimoto disease is so named because Kikuchi and Fujimoto were the first scientists to describe it in Japan in 1972. Although the disease has been reported from all over the world and more so from Asia, it is rare. To date only eight cases have been reported from Nepal. Cervical lymphadenopathy, fever and raised Erythrocyte Sedimentation Rate are usual presenting features of this disease. We describe a case which presented with thrombocytopenia and axillary lymphadenopathy in addition to the usual features. Out of the total eight cases that have been reported from Nepal so far, no patients had thrombocytopenia and only one patient had axillary lymphadenopathy. A 24-year-old Nepali female presented with a 3-week history of low-grade fever, headache, and painful, discrete, unilateral left-sided cervical and axillary lymphadenopathy. Among the multitude of tests that were carried out, Erythrocyte Sedimentation Rate was raised and there was thrombocytopenia while other tests were normal. Painful lymphadenopathy pointed to bacterial lymphadenitis while chronic low-grade fever suggested tuberculosis. A cervical lymph node was excised for histopathological examination to reach an accurate diagnosis. On the basis of pathognomonic features viz., paracortical foci composed of various types of histiocytes including crescentic type in the background of abundant apoptotic karyorrhectic debris, a diagnosis of Kikuchi-Fujimoto disease was made. On follow-up evaluation after 6 weeks, the patient had no systemic symptoms, enlarged lymph nodes had regressed in size significantly, and Erythrocyte Sedimentation Rate and platelet count had become normal. Kikuchi-Fujimoto disease should be kept in the differential diagnosis of lymphadenopathy in young patients, female or male even in tuberculosis-endemic countries and even in patients who have unusual features; for example thrombocytopenia and involvement of axillary lymph nodes in addition to cervical lymph nodes as in this

  14. Kikuchi-fujimoto disease, the masquerading menace: A rare case report

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    Rohit Kataria


    Full Text Available Kikuchi-Fujimoto disease (KFD or histiocytic necrotizing lymphadenitis is a rare, benign, self-limiting disease with unknown etiology characterized by regional lymphadenopathy. A 30-year-old female presented with fever, weakness, multiple joint pain, oral ulcers, erythematous facial rashes, hemorrhagic crusting on both lips, and cervical lymphadenopathy of 2-month duration. Clinically, the disease was mimicking systemic lupus erythematosus, but immunofluorescence was negative for it. Lymph node biopsy suggested a diagnosis of KFD.

  15. A Kikuchi-Fujimoto Disease Case Mimicking T Cell Lymphoma with Prolonged Fever

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    Serap Yadigar


    Full Text Available Kikuchi-Fujimoto disease (KFD is a self-limited disease characterized by necrotizing lymphadenitis. Although cervical lymphadenitis in young women is the most familiar clinical presentation, it may take place in the etiology of fever in cases presenting with fever of unknown origin. A 33-year-old male case admitted with fever, nausea, vomiting, weight loss, and leukopenia for one month, subsequently developing axillary lymphadenopathy during followup, diagnosed as KFD with typical histopathological findings, and showing full recovery after the excision of lymph node was presented in this report.

  16. Kikuchi-Fujimoto Disease in the United States: Three Case Reports and Review of the Literature


    Darcie M Deaver; Mojdeh Naghashpour; Lubomir Sokol


    Kikuchi-Fujimoto Disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a benign, self-limiting disease that manifests primarily as cervical lymphadenopathy but may include low-grade fever, headache, and fatigue.  There is a higher incidence of KFD in women aged 20-35 years and in Asian populations.  A PubMed search revealed 590 articles that described KFD.  Of these, 22 cases have been fully described in the United States.  Ten of the 22 (45%) patients were male and 12 (55%) ...

  17. Recurrent aseptic meningitis in association with Kikuchi-Fujimoto disease: case report and literature review

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    Komagamine Tomoko


    Full Text Available Abstract Background Kikuchi Fujimoto disease (KFD, or histiocytic necrotising lymphadenitis, is a benign and self-limiting condition characterised by primarily affecting the cervical lymph nodes. Recurrent aseptic meningitis in association with KFD is extremely rare and remains a diagnostic challenge. Case presentation We report a 28-year-old man who presented 7 episodes of aseptic meningitis associated with KFD over the course of 7 years. Histopathological findings of enlarged lymph nodes led to the diagnosis of KFD. The patient’s headache and lymphadenopathy spontaneously resolved without any sequelae. Conclusions A diagnosis of KFD should be considered when enlarged cervical lymph nodes are observed in patients with recurrent aseptic meningitis. A long-term prognosis remains uncertain, and careful follow-up is preferred.

  18. Kikuchi-Fujimoto Disease in the United States: Three Case Reports and Review of the Literature

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    Darcie M Deaver


    Full Text Available Kikuchi-Fujimoto Disease (KFD, also known as histiocytic necrotizing lymphadenitis, is a benign, self-limiting disease that manifests primarily as cervical lymphadenopathy but may include low-grade fever, headache, and fatigue.  There is a higher incidence of KFD in women aged 20-35 years and in Asian populations.  A PubMed search revealed 590 articles that described KFD.  Of these, 22 cases have been fully described in the United States.  Ten of the 22 (45% patients were male and 12 (55% were female, with 20% Caucasian, 20% Asian American, and the remaining 60% of other ethnic backgrounds.  In this study, we describe an additional 3 cases of KFD and discuss the diagnosis, pathology, and management of KFD.

  19. Kikuchi-Fujimoto disease: an unusual association with acute renal failure

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    Amanda Feliciano da Silva

    Full Text Available Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis of unknown etiopathogenesis, is a self-limited disease which frequently appears as feverish lymphadenomegaly, thus creating the need for differential diagnosis with lymphoma, systemic lupus erythematosus (SLE, infectious mononucleosis, cat-scratch disease, and toxoplasmosis with lymphonodal impairment. However, there are cases in which it may evolve with complications such as aseptic meningitis, cerebellar ataxia, and aseptic myocarditis. We are presenting a case of a 24-year-old man who had an initial picture of arthralgia, evening fever and adenomegaly. Kikuchi disease was diagnosed through lymph node biopsy with immunohistochemistry and evolves with severe systemic manifestations, such as pericarditis with cardiac tamponade, pneumonitis, hepatitis, and acute kidney failure - the latter has not been reported in literature yet. There was significant improvement of the clinical picture with prednisone

  20. Uveíte anterior como manifestação da Doença de Kikuchi e Fujimoto Anterior Uveitis as an ocular manifestation of Kikuchi and Fujimoto's Disease

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    Marco Aurelio Varella Figueiredo


    Full Text Available Apresentação de um caso de febre de origem obscura numa paciente feminina de 35 anos, com queda do estado geral, adenomegalia cervical posterior, monilíase oral, parotidite e irite.Após o parecer oftalmológico, o tratamento foi iniciado e posteriormente com o resultado do exame histopatológico de um linfonodo, diagnosticou-se a Doença de Kikuchi e Fujimoto. Sugerimos que a uveíte anterior seja reconhecida como mais um sinal de suspeita desta doença. São comentados os achados oculares, os aspectos histopatológicos e o tratamento da Doença de Kikuchi e Fujimoto.Report of a case on Kikuchi and Fujimoto's Disease in a young lady who developed a long standing spiking fever, weight loss, cervical adenomegalia, oral moniliasis, parotiditis and iritis.The histopathological findings, course and treatment as well as the importance of a multidisciplinar approach are commented.

  1. Doença de Kikuchi-Fujimoto: apresentação de um caso

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    Jailson de Sousa Oliveira


    Full Text Available A doença de Kikuchi-Fujimoto (DKF ou linfadenite histiocítica necrotizante é uma doença benigna e auto-limitada, rara, caracterizada por linfadenopatia generalizada, febre e leucopenia. É um importante diagnóstico diferencial com patologias linfoproliferativas, autoimunes, infecciosas, podendo em raros casos estar associada a estas. Relatamos o caso de um paciente de 24 anos, com quadro de febre, linfadenopatia cervical e inguinal e lesões cutaneomucosas. O Fator Anti-Nuclear (FAN foi positivo, hemograma evidenciou pancitopenia, anti-DNA negativo. A biópsia de linfonodo inguinal evidenciou linfadenite histiocítica necrotizante. O paciente evoluiu com piora clínica por atividade de doença associada a sepse, evoluindo com pericardite aguda e tamponamento cardíaco. Realizado pulsoterapia com ciclofosfamida, com melhora substancial das manifestações cutâneas e sistêmicas. O diagnóstico de pacientes com DKF deve implicar necessariamente no seguimento para avaliação do surgimento de doenças autoimunes, assim como doenças infecciosas e linfoproliferativas.

  2. Clinicopathological review of immunohistochemically defined Kikuchi-Fujimoto disease-including some interesting cases. (United States)

    Seong, Gil Myeong; Kim, Jo-Heon; Lim, Gil Chai; Kim, Jinseok


    Kikuchi-Fujimoto Disease (KFD) is a benign, self-limited disease characterized by tender regional lymphadenopathy with fever. KFD remains a poorly defined disease, and no clear diagnostic criteria are available. Here, we assess the clinical, laboratory, and histopathologic findings of KFD cases and report two unusual cases. Forty KFD patients that underwent lymph node (LN) biopsy and diagnosed by immunohistochemical staining, from January 2003 to November 2010, were enrolled in this retrospective study. The patients had a mean age of 29.3 years, and 29 (72.5 %) were women. Affected LNs were mainly located unilaterally in the cervical area. Mean LN size was 15.3 mm. Twenty-eight (70 %) patients had LN tenderness, and 25 (62.5 %) patients had fever. Leukopenia was observed in 18 of 35 evaluable patients. C-reactive protein and erythrocyte sedimentation rate were elevated in most patients. Anti-nuclear antibody was positive in four of 19 evaluable patients, but all had been diagnosed with concurrent systemic lupus erythematosus. Histologically, the 40 cases were classified into three types, that is, as proliferative (37.5 %), necrotizing (55.0 %), or xanthomatous (7.5 %). Interesting cases: Case 1 was a 35-year-old female with KFD and uveitis, retinal vasculitis, and superior sagittal sinus thrombosis. Case 2 was a 47-year-old male with KFD and bone marrow involvement and presented with severe bicytopenia. Although KFD is an uncommon self-limited benign disorder, it must be included in the differential diagnosis of lymphadenopathy with fever and cytopenia. It is important that the clinical features of KFD be understood to reach a correct diagnosis.

  3. Disseminated intravascular coagulopathy caused by Kikuchi–Fujimoto disease resulting in death: first case report in Turkey

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    Uslu E


    Full Text Available Emine Uslu,1 Sibel Gurbuz,2 Abdulsamet Erden,1 Fatma Aykas,1 Hatice Karagoz,1 Samet Karahan,1 Hatice Karaman,3 Ali Cetinkaya,1 Deniz Avci1 1Internal Medicine Department, 2Infection Disease Department, 3Clinical Pathology Department, Kayseri Training and Research Hospital, Kayseri, Turkey Abstract: Kikuchi disease, also called Kikuchi–Fujimoto disease or Kikuchi's histiocytic necrotizing lymphadenitis, is a rare, benign condition of unknown cause, usually characterized by cervical lymphadenopathy and fever. The diagnosis is based on histopathology. Our patient was a woman with bilateral cervical lymphadenopathy, fever, chest and abdominal pain, fatigue, maculopapular rash on her face, trunk, and upper and lower extremities. Immunological and rheumatological tests were negative. We took a cervical lymph node biopsy that showed a proliferative and necrotizing process centered in the paracortex characterized by patchy circumscribed or confluent areas of necrosis associated with karyorrhexis, and was remarkable by the absence of granulocytes and the paucity of plasma cells. These findings confirmed the diagnosis of Kikuchi's disease. The patient's hemoglobin values decreased, and the peripheral blood smear revealed schistocytes. Blood tests showed raised D-dimer, activated partial thromboplastin time, prothrombin time, and international normalized ratio with decreased fibrinogen. The patient's condition quickly worsened and disseminated intravascular coagulopathy eventually developed. Her initial management consisted of a corticosteroid and hydroxychloroquine. Keywords: disseminated intravascular coagulopathy, Kikuchi–Fujimoto disease, necrotizing lymphadenitis

  4. Bilateral pleural effusion and interstitial lung disease as unusual manifestations of kikuchi-fujimoto disease: case report and literature review

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    Magdalena Fernandez-Martinez


    Full Text Available Abstract Background Kikuchi-Fujimoto's disease (KFD, also called histiocytic necrotizing lymphadenitis, is a rare, idiopathic and self-limited condition usually characterized by cervical lymphadenopathy and fever, most often affecting young patients. Aetiology is unknown. Differential diagnosis includes mainly malignant lymphoma, tuberculous lymphadenitis and systemic lupus erythematosus (SLE, so early diagnosis is crucial. Pleuropulmonary involvement due to isolated KFD has been seldom reported. Case Presentation a 32-year-old man, on treatment for iatrogenic hypothyroidism, was admitted due to high grade fever and painful cervical lymphadenopathies. KFD was diagnosed by lymph node biopsy. Some days after admission the patient got worse, he developed generalized lymphadenopathy, bilateral pleural effusion and interstitial lung disease. All of them resolved with prednisone and after two years of following up he remains asymptomatic and without evidence of any other associated disease. Conclusion Pleural effusion and interstitial lung disease are very uncommon manifestations of KFD. In our experience, treatment with oral prednisone was effective.

  5. Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease after laparoscopic Roux-en-Y gastric bypass for morbid obesity: a case report

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    Garcia-Arnes Juan


    Full Text Available Abstract Introduction Kikuchi-Fujimoto disease, or histiocytic necrotizing lymphadenitis, is a rare, benign, autoimmune condition characterized by lymphadenopathy, fever and neutropenia. It is a self-limited condition of unknown etiology. Case presentation We report the case of a 45-year-old Caucasian man with the first known case of Kikuchi disease associated with dramatic weight loss after bariatric surgery. Conclusion Although the association between Kikuchi disease and bariatric surgery may be entirely coincidental, we speculate whether the immune dysfunction associated with weight loss may have played an etiologic role in this process.

  6. Mälu ja tunnustamine: 2011 kui kahekordne tähtaasta Jaapani ja Eesti suhetes / Hiromi Komori

    Index Scriptorium Estoniae

    Komori, Hiromi, 1969-


    Jaapani ja Eesti suhetest. Jaapani valitsus võttis vastu otsuse Eesti iseseisvuse tunnustamise kohta de jure 26. jaanuaril 1921. Jaapani saatkond avati Riias 1929. 8. detsembril 1939 avati Tallinnas Jaapani diplomaatiline büroo. Diplomaatilisse büroosse suunatud diplomaat Shimada sai Tallinnas tegutseda ainult üheksa kuud. Eesti annekteerimise de facto tunnustamisest ja diplomaatilise büroo sulgemisest

  7. Interface dermatitis in skin lesions of Kikuchi-Fujimoto's disease: a histopathological marker of evolution into systemic lupus erythematosus? (United States)

    Paradela, S; Lorenzo, J; Martínez-Gómez, W; Yebra-Pimentel, T; Valbuena, L; Fonseca, E


    Kikuchi's disease (KD) is a self-limiting histiocytic necrotizing lymphadenitis (HNL). Cutaneous manifestations are frequent and usually show histopathological findings similar to those observed in the involved lymph nodes. HNL with superposed histological features to KD has been described in patients with lupus erythematosus (LE), and a group of healthy patients previously reported as having HNL may evolve into LE after several months. Up to date, features to predict which HNL patients will have a self-limiting disease and which could develop LE have been not identified. In order to clarify the characteristics of skin lesions associated with KD, we report a case of HNL with evolution into systemic lupus erythematosus (SLE) and a review of previous reports of KD with cutaneous manifestations. A 17-year-old woman presented with a 4-month history of fever and generalised lymphadenopathy. A diagnosis of HNL was established based on a lymph node biopsy. One month later, she developed an erythematoedematous rash on her upper body, with histopathological findings of interface dermatitis. After 8 months, anti-nuclear antibodies (ANA) at titre of 1/320, anti-DNA-ds antibodies and marked decrease of complement levels were detected. During the following 2 years, she developed diagnostic criteria for SLE, with arthralgias, pleuritis, aseptic meningitis, haemolytic anaemia and lupus nephritis. To our knowledge, 27 cases of nodal and cutaneous KD have been reported, 9 of which later developed LE. In all these patients, the skin biopsy revealed interface dermatitis. Skin biopsy revealed a pattern of interface dermatitis in all reviewed KD cases, which evolved into LE. Even this histopathological finding was not previously considered significant; it might be a marker of evolution into LE.

  8. Case report

    African Journals Online (AJOL)


    28 juin 2017 ... Key words: Kikuchi-Fujimoto disease, histiocytic necrotizing lymphadenitis, adenopathies. Introduction. La maladie de Kikuchi-Fujimoto (KF) ou lymphadénite histiocytaire nécrosante est une affection ganglionnaire bénigne, décrite pour la première fois en 1972 au japon par Kikuchi et Fujimoto. Elle touche.

  9. Atypical presentation of dopa-responsive dystonia in Taiwan. (United States)

    Weng, Yi Ching; Wang, Chun Chieh; Wu, Yih Ru


    The typical clinical presentation of dopa-responsive dystonia, which is also called Segawa disease, is a young age of onset, with predominance in females, diurnal fluctuation of lower limb dystonia, and fair response to low-dose levodopa. This disease has both autosomal dominant and autosomal recessive inheritance. Autosomal dominant Segawa disease is caused by GCH1 mutation on chromosome 14q22.1-q22.2. Here, we report the case of a male patient with genetically confirmed Segawa disease and atypical presentations including no diurnal symptom fluctuation and insufficient response to levodopa. The patient's father who had the same mutation presented parkinsonism in old age. We also review the literature to address the broad clinical heterogeneity of Segawa disease and the influence of onset age on clinical presentation.

  10. This corrects the article " Kikuchi-Fujimoto Disease in the Unites States: Three Case Reports and Review of the Literature" in volume 6, e2014001, link:

    Directory of Open Access Journals (Sweden)

    Darcie Deaver


    Full Text Available Due to a layout error, in the title Unites must be canged on United. At the first row of the abstract histiocytic lymphadenitis must be canged on histiocytic necrotizing lymphadenitis.

  11. JCSC_129_11_1661_1669_SI.docx

    Indian Academy of Sciences (India)

    Priyanka Verma

    PRIYANKA VERMA,a MIRIAM NAVLANI-GARCÍA,a YASUTAKA KUWAHARA,a,b KOHSUKE MORI,a,b,c and HIROMI YAMASHITA*a,b. aDivision of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita, Japan. bUnit of Elements Strategy Initiative for Catalysts ...

  12. Imploding spherical and cylindrical shocks (United States)

    Yousaf, M.


    In this paper it is shown that the value of the similarity exponent α derived analytically by Fujimoto and Mishkin [J. Fluid Mech. 89, 61 (1978); Phys. Fluids 21, 1933 (1978)] is exactly the same as that found by Stanyukovich [Unsteady Motion of Continuous Media, (Academic, New York, 1960)]. Since the result found by Stanyukovich is an approximation to α, Fujimoto and Mishkin's claim to have an exact expression of α is false. The two methods are outlined and Stanyukovich's result is simplified to show its equivalence to the work of Fujimoto and Mishkin.

  13. Comments on ''Analysis of spherical imploding shocks''

    International Nuclear Information System (INIS)

    Lazarus, R.B.


    It is asserted that Fujimoto and Mishkin's article is incorrect in its claim for a pressure extremum at or behind the shock for all values of γ and in its claim for an analytical form for the similarity exponent

  14. RLE (Research Laboratory of Electronics) Progress Report Number 130 (United States)


    Ippen, James G. Fujimoto, Wei-Zhu Lin, Beat Zysset, Robert W. Schoenlein, 4 Michael J. Lagasse The investigation of transient carrier dynamics in GaAs...G. Fujimoto, Wei-Zhu Lin, Reginald Birngruber, Beat Zysset, Robert W. Schoenleln Working in collaboration with researchers at the Massachusetts Eye... Binaural Hearing National Institutes of Health (Grant 5 RO 1 NS 10916) H. Steven Colburn, Nathaniel 1. Durlach, Patrick M. Zurek 17 Brooklyn College14 141

  15. Fatigue 󈨛. Papers presented at the International Conference on Fatigue and Fatigue Threshold (3rd) Held in Charlottesville, Virginia on June 28-July 3, 1987. Volume 3. (United States)


    rI ONAL 2/6 UNCLASSIFIED P" 4140 fPh ICNlLjG UN rwPLI/6.1 ML. 111111.03128 I2.2 11-1 111112 11.8 IIIJIL25 .4 MICROCOPY RESOLUTION TEST CHART NATIONAL...interval. Tnis strain data was then fitted by ARMA models. The material selected was SAE bolt steel, grade 2. The ultimate strength of this steel is 74 Ksi...2 K. Iwamoto ; JSAE Symp.(1978). 3 H. Kitagawa, T. Satoh and M. Fujimoto ; SAE 850371 (1985) 4 Fujimoto ; JSAE Symp (1985). 5 J. Niizawa, Tomioka,et

  16. Fever, sore throat and myalgia

    African Journals Online (AJOL)

    Occult bacterial abscess. Renal carcinoma. Variants of rheumatoid arthritis. Kikuchi-Fujimoto disease. Endocarditis. Atrial myxoma. Systemic lupus erythematosus. Melioidosis. Brucellosis. Temporal arteritis. Polymyalgia rheumatica. Pyrexia of unknown origin defined as temperature >38.3oC for >3 weeks, with >2 outpatient ...

  17. Comments on ''Analysis of spherical imploding shocks''

    Energy Technology Data Exchange (ETDEWEB)

    Lazarus, R.B.


    It is asserted that Fujimoto and Mishkin's article is incorrect in its claim for a pressure extremum at or behind the shock for all values of ..gamma.. and in its claim for an analytical form for the similarity exponent. (AIP)

  18. Panel: The Future of Research in Modeling & Simulation (United States)


    Fomel and Claerbout 2009; Stodden 2010). It refers to the ability to recreate simulation results from existing simulation code and data...379(1): 317-333. 2809 Yilmaz, Taylor, Fujimoto, and Darema Stodden , V. 2010. “The Scientific Method in Practice: Reproducibility in the

  19. DMPD: Regulation of cytokine signaling by SOCS family molecules. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 14644140 Regulation of cytokine signaling by SOCS family molecules. Fujimoto M, Nak...a T. Trends Immunol. 2003 Dec;24(12):659-66. (.png) (.svg) (.html) (.csml) Show Regulation of cytokine signaling by SOCS family... molecules. PubmedID 14644140 Title Regulation of cytokine signaling by SOCS family molec

  20. Book Reviews

    Directory of Open Access Journals (Sweden)

    H. Th. Fischer


    Full Text Available - A. Teeuw, C.C. Brown, Studies in country Malay, London 1956, XI and 259 pp. - C. Ouwehand, Kano Tadao, An illustrated ethnography of Formosan aborigines, Vol. I The Yami. Revised edition, Tokyo 1956, XII + 18 + 456 pp., Segawa Kokichi (eds. - G.D. van Wengen, Mantle Hood, The nuclear theme as a determinant of patet in Javanese music, (Diss. Amsterdam 1954. - H. Th. Fischer, P. Schebesta, Die negrito Asiens. II: Ethnographie der Negrito. 1. Wirtschaft und Soziologie. (1954. 2. Religion und Mythologie. (1957. St-Gabriel-Verlag. Wien-Mödling.

  1. Record of Operations Against Soviet Russia on Northern and Western Fronts of Manchuria, and in Northern Korea (August 1945) (United States)


    Col Masao Segawa Col Kaoru Okano Col Shigeru Imada - Maj Akizo Yokoyama Capt Toyonobu Kondo Maj Toru Mi tano - Lt Col Sen Nagai - 1st Lt Ichiro...nchurians, and its commander, 1st Lieutenant Ishikawa , was killed. The only unit of the division to engage in action--the 5th Company of the 24lst...Lieutenant: 161 Irie, Major: 43 Ishikawa , 1st Lt: 160 Itung River: 15, 37, 42-43 Iwai, Lt Gen, Torajiro (Cmdr lOath Div): 143, 147-48, 154 Japanese

  2. A comparison of a patient-rated visual analogue scale with the Liebowitz Social Anxiety Scale for social anxiety disorder: A cross-sectional study


    興津, 裕美


    博士(医学) 乙第2814号, 著者名:Hiromi Okitsu・Jitsuki Sawamura・Katsuji Nishimura・Yasuto Sato・Jun Ishigooka,タイトル:A comparison of a patient-rated visual analogue scale with the Liebowitz Social Anxiety Scale for social anxiety disorder: A cross-sectional study,掲載誌:Open Journal of Psychiatry (2161-7325),巻・頁・年:4巻1号 p.68~74 (2014),著作権関連情報:Copyright © 2014 by authors and Scientific Research Publishing Inc.,DOI:10.4236/ojpsych.2014.41010...

  3. Bilateral painful parotid lumps and a lump in the groin: An uncommon presentation of common Kikuchi's disease

    Directory of Open Access Journals (Sweden)

    Sumeet Prakash Mirgh


    Full Text Available Kikuchi-Fujimoto disease (KFD is an under-recognized disease most commonly presenting with cervical lymphadenopathy, fever, and cytopenias in young females. Bilateral parotid enlargement is usually caused by infections (e.g., mumps and autoimmune conditions (e.g., Sjogren syndrome. Parotid enlargement, inguinal lymphadenopathy, and pyrexia of unknown origin are uncommon presenting features of KFD and should be suspected in the appropriate setting.

  4. Development of In Vitro Correlate Assays of Immunity to Infection with Yersinia Pestis (United States)


    cynomolgus macaques (CM) and African green (Chlorocebus aethiops) monkeys (AGM) vaccinated s.c. three times at 4-week intervals with the F1-V fusion...Yersinia pestis in African green monkeys . Arch. Pathol. Lab. Med. 120:156–163. 15. Faure, K., J. Fujimoto, D. W. Shimabukuro, T. Ajayi, N. Shime, K...A. Kuwae, C. Sasakawa, and S. Imajoh-Ohmi. 1999. Shigella flexneri YSH6000 induces two types of cell death, apoptosis and oncosis, in the

  5. North Korean Policy Elites (United States)


    by Kim’s former Japanese chef , Kenji Fujimoto, reveal that Kim could get just about anything he wanted in his personal life, from foreign delicacies...for his table to Japanese jet skis and Sony home electronics.9 Likewise, the account of Yi Nam-oak (Li Nam-ok), who grew up as a companion to Kim’s...title Kin Seinichi no Ryoryinin [Kim Jong-il’s Chef ], Tokyo: Fusosha, 2003. The title of the Korean edition is Kim Jong-il ui yorisa. FBIS translated

  6. Project origami activities for exploring mathematics

    CERN Document Server

    Hull, Thomas


    IntroductionActivity 1 Folding Equilateral Triangles in a Square Activity 2 Origami Trigonometry Activity 3 Dividing a Length into Equal Nths: Fujimoto Approximation Activity 4 Dividing a Length into Equal Nths Exactly Activity 5 Origami Helix Activity 6 Folding a Parabola Activity 7 Can Origami Trisect an Angle?Activity 8 Solving Cubic Equations Activity 9 Lill's Method Activity 10 Folding Strips into Knots Activity 11 Haga's ""Origamics"" Activity 12 Modular Star Ring Activity 13 Folding a Butterfly Bomb Activity 14 Molly's Hexahedron Activity 15 Business Card Modulars Activity 16 Five Inter

  7. SLCO2B1 and SLCO1B3 as New Targets for Enhancing Androgen Deprivation Therapy for Prostate Cancer (United States)


    time. Relative cell numbers were calculated as percentages of the cell numbers at day 0 (100%). this study (shRNA-SLCO2B1). After successfully...cosponsored by the American Society of Preventive Oncology. Apr 2011;20(4):619-627. 3. Fujimoto N, Kubo T, Inatomi H, et al. Polymorphisms of the...DHEAS and 200 nM ATO to the culture medium for the indicated time. Relative cell numbers were calculated as percentages of the cell numbers at day 0

  8. First experimental results on the kinetic processes in a surface-wave-sustained argon discharge at atmospheric pressure

    International Nuclear Information System (INIS)

    Calzada, M.D.; Gamero, A.; Sola, A.


    This communication presents an advance of the results of an experimental study of the kinetic processes in a surface-wave-sustained argon discharge at atmospheric pressure. We utilize the study developed by Fujimoto on the population and depopulation processes of the excited levels of atoms and ions. This theory has been applied by S. Daviaud and A. Hirabayashi to explain the kinetic processes in helium plasma at low pressure. Fujimoto has studied the ionization and recombination mechanisms of the plasma under various conditions and its relation to the population density distributions. This study establishes, for an hydrogenic ion with a core charge z, different zones in the atomic system (level map). Each zone is characterized by the dominant mechanisms of the population and depopulation of their excited levels, A level is characterized for the effective principal quantum number p, where p = z (E H /|E p |) 1/2 , E H is the hydrogen ionization energy and |E p | is the energy required to ionize the atom from the level considered. The population of each level p can be expressed in terms of the parameter b(p) defined as n(p)/n SB (p), n(p) and n SB (p) being the actual population and the Saha-Boltzmann equilibrium population of the level, respectively. Figure I shows the population and depopulation processes of a level p, which are both collisional and radiative that are characterized by their respective coefficients

  9. Clinical features and pharmacotherapy of childhood monoamine neurotransmitter disorders. (United States)

    Ng, J; Heales, S J R; Kurian, M A


    Childhood neurotransmitter disorders are increasingly recognised as an expanding group of inherited neurometabolic syndromes. They are caused by disturbance in synthesis, metabolism, and homeostasis of the monoamine neurotransmitters, including the catecholamines (dopamine, norepinephrine, and epinephrine) and serotonin. Disturbances in monoamine neurotransmission will lead to neurological symptoms that often overlap with clinical features of other childhood neurological disorders (such as hypoxic ischaemic encephalopathy, cerebral palsy, other movement disorders, and paroxysmal conditions); consequently, neurotransmitter disorders are frequently misdiagnosed. The diagnosis of neurotransmitter disorders is made through detailed clinical assessment, analysis of cerebrospinal fluid neurotransmitters, and further supportive diagnostic investigations. Early and accurate diagnosis of neurotransmitter disorders is important, as many are amenable to therapeutic intervention. The principles of treatment for monoamine neurotransmitter disorders are mainly directly derived from understanding these metabolic pathways. In disorders characterized by enzyme deficiency, we aim to increase monoamine substrate availability, boost enzyme co-factor levels, reduce monoamine breakdown, and replace depleted levels of monoamines with pharmacological analogs as clinically indicated. Most monoamine neurotransmitter disorders lead to reduced levels of central dopamine and/or serotonin. Complete amelioration of motor symptoms is achievable in some disorders, such as Segawa's syndrome, and, in other conditions, significant improvement in quality of life can be attained with pharmacotherapy. In this review, we provide an overview of the clinical features and current treatment strategies for childhood monoamine neurotransmitter disorders.

  10. Study on CT changes in autistic children

    International Nuclear Information System (INIS)

    Yaguchi, Katsumi


    Since 1979 we have performed CT examinations on 132 autistic children. Neurological diagnosis of the lesion was established by Dr. Segawa's group. On the CT of many autistic children, we found a small low density change located in the anterior wall of the temporal horn, or localized dilatation of the inferior horn near the damaged brain. We reviewed 96 of these patients who all had the obvious low density changes, or localized irregular dilatations in the anterior wall of the temporal horn. By measuring the distance of damage from the midline, we divided the 96 cases into two groups. Group 1 consisted of those with damage located laterally more than 30 mm line from the midline. Group 2 consisted of those with damage medially to the 30 mm line from the midline. Those cases with a large lesion both laterally and medially of the 30 mm line were categorized into group 1. In the adult brain the lateral border of the amygdaloid nucleus was never located laterally more than 30 mm from the midline. Laterally over the 30 mm line there were two marked fiber systems running near the anterior wall of the temporal horn: the fiber of the anterior commissure and the uncinate fascicle. Group 1 consisted of 62 patients and group 2 of 34 patients. The majority of the two group patients were pure autism children. This suggested that the main lesion in autism was in the amygdala. (author)

  11. Study on CT changes in autistic children; Anatomical correlation of the damaged brain and delay of psychomotor development

    Energy Technology Data Exchange (ETDEWEB)

    Yaguchi, Katsumi [Juntendo Univ., Tokyo (Japan). School of Medicine


    Since 1979 we have performed CT examinations on 132 autistic children. Neurological diagnosis of the lesion was established by Dr. Segawa's group. On the CT of many autistic children, we found a small low density change located in the anterior wall of the temporal horn, or localized dilatation of the inferior horn near the damaged brain. We reviewed 96 of these patients who all had the obvious low density changes, or localized irregular dilatations in the anterior wall of the temporal horn. By measuring the distance of damage from the midline, we divided the 96 cases into two groups. Group 1 consisted of those with damage located laterally more than 30 mm line from the midline. Group 2 consisted of those with damage medially to the 30 mm line from the midline. Those cases with a large lesion both laterally and medially of the 30 mm line were categorized into group 1. In the adult brain the lateral border of the amygdaloid nucleus was never located laterally more than 30 mm from the midline. Laterally over the 30 mm line there were two marked fiber systems running near the anterior wall of the temporal horn: the fiber of the anterior commissure and the uncinate fascicle. Group 1 consisted of 62 patients and group 2 of 34 patients. The majority of the two group patients were pure autism children. This suggested that the main lesion in autism was in the amygdala. (author).

  12. A case of schizophrenia comorbid for tetralogy of Fallot treated with clozapine: further considerations on a role for 22q.11.2 in the proneness for seizures

    Directory of Open Access Journals (Sweden)

    Kashiwagi H


    Full Text Available Hiroko Kashiwagi,1 Satoru Ikezawa,2 Tomiki Sumiyoshi,3 Atsuko Kadono,4 Kazuhiko Segawa,5 Kazuyoshi Takeda,1 Mayu Omori,1 Hisako Taguchi,1 Naotsugu Hirabayashi1 1Department of Forensic Psychiatry, 2Department of Psychiatry, 3Department of Clinical Epidemiology, Translational Medical Center, National Center Hospital of Neurology and Psychiatry, Kodaira, Tokyo, 4Saitama Psychiatric Medical Center, Kitaadatigun, Saitama, 5Department of General Medicine, National Center Hospital of Neurology and Psychiatry, Kodaira, Tokyo, Japan Abstract: We present a case of schizophrenia comorbid for tetralogy of Fallot, without chromosome 22q.11.2 deletion or duplication, treated successfully with a combination of clozapine and antiepileptic drugs. Although clozapine by itself initially triggered convulsive seizures, we continued it with co-administration of valproate and topiramate. This combined treatment did not affect cardiac function of the patient, who experienced a favorable clinical course in terms of symptomatology and functional outcomes. To our knowledge, we provide the first report on a patient with tetralogy of Fallot, in whom 22q.11.2 was not deleted and clozapine-induced seizures were observed. Keywords: schizophrenia, clozapine, tetralogy of Fallot, seizure, copy number variants

  13. Three-dimensional analysis of the magnetic structure in Hokkaido, Japan; Hokkaido no sanjigen jiki kozo kaiseki

    Energy Technology Data Exchange (ETDEWEB)

    Makino, M [Geological Survey of Japan, Tsukuba (Japan)


    The magnetic structure in Hokkaido was quantitatively analyzed by the magnetic anomaly distribution. This paper describes its characteristics. Detection of structural boundaries and 3-D analysis of double-layer structure were conducted for the regional magnetic data in a region with about 500 km square. There was not so large difference in patterns of magnetic anomaly distribution between the case that the direction of magnetization was set at 45{degree} to the west during the geomagnetic conversion according to Segawa and Oshima and the case that it was set as same as the current geomagnetic direction. The method of Blakely and Simpson was useful to detect the boundaries of magnetic structures. The structural boundaries obtained were more linear than the iso-magnetic contour lines. A new method has been conceived in which the approximation of 3-D magnetic structure analysis can be deduced, and the irregularity of magnetic basement can be determined by the repeated calculation. In practice, this method was applied to the magnetic data in the whole Hokkaido. The calculation was stably converged. It was found that the magnetic structure obtained in the Kamuikotan/Ishikari-Kitakami magnetic belt exhibited a fault structure having steep slopes accompanied by the basin structure in the western boundaries. 19 refs., 6 figs.

  14. Study on CT changes in autistic children; Anatomical correlation of the damaged brain and delay of psychomotor development

    Energy Technology Data Exchange (ETDEWEB)

    Yaguchi, Katsumi (Juntendo Univ., Tokyo (Japan). School of Medicine)


    Since 1979 we have performed CT examinations on 132 autistic children. Neurological diagnosis of the lesion was established by Dr. Segawa's group. On the CT of many autistic children, we found a small low density change located in the anterior wall of the temporal horn, or localized dilatation of the inferior horn near the damaged brain. We reviewed 96 of these patients who all had the obvious low density changes, or localized irregular dilatations in the anterior wall of the temporal horn. By measuring the distance of damage from the midline, we divided the 96 cases into two groups. Group 1 consisted of those with damage located laterally more than 30 mm line from the midline. Group 2 consisted of those with damage medially to the 30 mm line from the midline. Those cases with a large lesion both laterally and medially of the 30 mm line were categorized into group 1. In the adult brain the lateral border of the amygdaloid nucleus was never located laterally more than 30 mm from the midline. Laterally over the 30 mm line there were two marked fiber systems running near the anterior wall of the temporal horn: the fiber of the anterior commissure and the uncinate fascicle. Group 1 consisted of 62 patients and group 2 of 34 patients. The majority of the two group patients were pure autism children. This suggested that the main lesion in autism was in the amygdala. (author).

  15. FY 1998 annual report on the fourth international forum on environmental catalysis (IFEC 99); Dai 4 kai kankyo shokubai kokusai forum (IFEC '99) 1998 nendo hokokusho

    Energy Technology Data Exchange (ETDEWEB)



    The 4th international forum on environmental catalysis, held in January 1999 in Chemical Society of Japan's Hall, had a total attendees exceeding 170, including 10 foreign attendees invited. A total of 20 papers (including 10 by foreign attendees) were presented, discussing diversified problems; 3 keynote addresses regarding (to what extent environmental catalyst can contribute); and 5 for the session of catalysts for clean processes, 6 for the session of eco-friendly chemistry, and 8 for the session of environmental catalysts for air pollution. The lectures included (global environmental problems and environmental catalysts) by Prof. Segawa of Sophia University as the opening address; solid base catalysts by Prof. Ono of Tokyo Institute of Technology in the session of (catalysts for clean processes); activation of dioxygen by transition metal complexes-new approach to highly selective catalytic oxidation with molecular oxygen by Prof. Moro-oka of Tokyo Institute of Technology in the session of (Eco-friendly chemistry; and environmental catalysts-present and future as the comprehensive review by Prof. Misono of University of Tokyo in the session of (environmental catalysts for air pollution). (NEDO)

  16. Advances in mathematical economics

    CERN Document Server

    Yamazaki, Akira


    A lot of economic problems can be formulated as constrained optimizations and equilibration of their solutions. Various mathematical theories have been supplying economists with indispensable machineries for these problems arising in economic theory. Conversely, mathematicians have been stimulated by various mathematical difficulties raised by economic theories. The series is designed to bring together those mathematicians who are seriously interested in getting new challenging stimuli from economic theories with those economists who are seeking effective mathematical tools for their research. The editorial board of this series comprises the following prominent economists and mathematicians: Managing Editors: S. Kusuoka (Univ. Tokyo), T. Maruyama (Keio Univ.). Editors: R. Anderson (U.C. Berkeley), C. Castaing (Univ. Montpellier), F.H. Clarke (Univ. Lyon I), G. Debreu (U.C. Berkeley), E. Dierker (Univ. Vienna), D. Duffie (Stanford Univ.), L.C. Evans (U.C. Berkeley), T. Fujimoto (Okayama Univ.), J.-M. Grandmont...

  17. Expected Power-Utility Maximization Under Incomplete Information and with Cox-Process Observations

    International Nuclear Information System (INIS)

    Fujimoto, Kazufumi; Nagai, Hideo; Runggaldier, Wolfgang J.


    We consider the problem of maximization of expected terminal power utility (risk sensitive criterion). The underlying market model is a regime-switching diffusion model where the regime is determined by an unobservable factor process forming a finite state Markov process. The main novelty is due to the fact that prices are observed and the portfolio is rebalanced only at random times corresponding to a Cox process where the intensity is driven by the unobserved Markovian factor process as well. This leads to a more realistic modeling for many practical situations, like in markets with liquidity restrictions; on the other hand it considerably complicates the problem to the point that traditional methodologies cannot be directly applied. The approach presented here is specific to the power-utility. For log-utilities a different approach is presented in Fujimoto et al. (Preprint, 2012).

  18. Expected Power-Utility Maximization Under Incomplete Information and with Cox-Process Observations

    Energy Technology Data Exchange (ETDEWEB)

    Fujimoto, Kazufumi, E-mail: [Bank of Tokyo-Mitsubishi UFJ, Ltd., Corporate Risk Management Division (Japan); Nagai, Hideo, E-mail: [Osaka University, Division of Mathematical Science for Social Systems, Graduate School of Engineering Science (Japan); Runggaldier, Wolfgang J., E-mail: [Universita di Padova, Dipartimento di Matematica Pura ed Applicata (Italy)


    We consider the problem of maximization of expected terminal power utility (risk sensitive criterion). The underlying market model is a regime-switching diffusion model where the regime is determined by an unobservable factor process forming a finite state Markov process. The main novelty is due to the fact that prices are observed and the portfolio is rebalanced only at random times corresponding to a Cox process where the intensity is driven by the unobserved Markovian factor process as well. This leads to a more realistic modeling for many practical situations, like in markets with liquidity restrictions; on the other hand it considerably complicates the problem to the point that traditional methodologies cannot be directly applied. The approach presented here is specific to the power-utility. For log-utilities a different approach is presented in Fujimoto et al. (Preprint, 2012).

  19. Managing refractory Crohn's disease: challenges and solutions

    Directory of Open Access Journals (Sweden)

    Tanida S


    Full Text Available Satoshi Tanida, Keiji Ozeki, Tsutomu Mizoshita, Hironobu Tsukamoto, Takahito Katano, Hiromi Kataoka, Takeshi Kamiya, Takashi Joh Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Aichi Prefecture, Japan Abstract: The goals of treatment for active Crohn's disease (CD are to achieve clinical remission and improve quality of life. Conventional therapeutics for moderate-to-severe CD include 5-aminosalicylic acid, corticosteroids, purine analogs, azathioprine, and 6-mercaptopurine. Patients who fail to respond to conventional therapy are treated with tumor necrosis factor (TNF-α inhibitors such as infliximab and adalimumab, but their efficacy is limited due to primary nonresponse or loss of response. It is suggested that this requires switch to another TNF-α inhibitor, a combination therapy with TNF-α blockade plus azathioprine, or granulocyte and monocyte adsorptive apheresis, and that other therapeutic options having different mechanisms of action, such as blockade of inflammatory cytokines or adhesion molecules, are needed. Natalizumab and vedolizumab are neutralizing antibodies directed against integrin a4 and a4ß7, respectively. Ustekinumab is a neutralizing antibody directed against the receptors for interleukin-12 and interleukin-23. Here, we provide an overview of therapeutic treatments that are effective and currently available for CD patients, as well as some that likely will be available in the near future. We also discuss the advantages of managing patients with refractory CD using a combination of TNF-α inhibitors plus azathioprine or intensive monocyte adsorptive apheresis. Keywords: adalimumab, granulocyte and monocyte adsorptive apheresis, combination therapy, complete remission

  20. Interacting star clusters in the Large Magellanic Cloud. Overmerging problem solved by cluster group formation (United States)

    Leon, Stéphane; Bergond, Gilles; Vallenari, Antonella


    We present the tidal tail distributions of a sample of candidate binary clusters located in the bar of the Large Magellanic Cloud (LMC). One isolated cluster, SL 268, is presented in order to study the effect of the LMC tidal field. All the candidate binary clusters show tidal tails, confirming that the pairs are formed by physically linked objects. The stellar mass in the tails covers a large range, from 1.8x 10(3) to 3x 10(4) \\msun. We derive a total mass estimate for SL 268 and SL 356. At large radii, the projected density profiles of SL 268 and SL 356 fall off as r(-gamma ) , with gamma = 2.27 and gamma =3.44, respectively. Out of 4 pairs or multiple systems, 2 are older than the theoretical survival time of binary clusters (going from a few 10(6) years to 10(8) years). A pair shows too large age difference between the components to be consistent with classical theoretical models of binary cluster formation (Fujimoto & Kumai \\cite{fujimoto97}). We refer to this as the ``overmerging'' problem. A different scenario is proposed: the formation proceeds in large molecular complexes giving birth to groups of clusters over a few 10(7) years. In these groups the expected cluster encounter rate is larger, and tidal capture has higher probability. Cluster pairs are not born together through the splitting of the parent cloud, but formed later by tidal capture. For 3 pairs, we tentatively identify the star cluster group (SCG) memberships. The SCG formation, through the recent cluster starburst triggered by the LMC-SMC encounter, in contrast with the quiescent open cluster formation in the Milky Way can be an explanation to the paucity of binary clusters observed in our Galaxy. Based on observations collected at the European Southern Observatory, La Silla, Chile}

  1. Dopa-sensitive progressive dystonia of childhood with diurnal fluctuations of symptoms: a case report

    Directory of Open Access Journals (Sweden)

    José Luiz Dias Gherpelli


    Full Text Available Progressive dystonia with diurnal fluctuations sensitive to levodopa, also known as Segawa's disease, is a rare form of autosomal dominant extrapyramidal disease in the pediatric age group. The dystonic and Parkinson-like symptoms are the main clinical features of the disease and, characteristically but not in all cases, show a diurnal variation. They are absent or present to a lesser extent in the morning, worsening during the day. Treatment with small doses of levodopa results in remission or marked improvement of the symptomatology. We present the case of a 11 years old female patient that developed a dystonic posture in her feet that led her to a tip-toe walking pattern, since the age of 2. Diurnal fluctuations of the symptomatology were noticed by her mother. At 7 years of age she developed a left deviation of the head and an abnormal flexor posture of the left arm. In the next years the symptoms progressed and the fluctuations became less evident. At the age of 10, they were present soon after she woke up in the morning. The neurological examination disclosed a dystonic posturing of the head and left arm, a generalized rigidity of the extremities and a palpebral tremor. Laboratory examinations, including copper and ceruloplasmin, and neuro-imaging studies were negative. She was started on levodopa 150 mg/day with prompt disappearance of the symptomatology. After one-year follow-up she is symptom-free with only 100 mg/day of levodopa. No adverse effect was observed so far.

  2. Availability of a remote online hemodynamic monitoring system during treatment in a private dental office for medically high-risk patients

    Directory of Open Access Journals (Sweden)

    Shinya Yamazaki


    Full Text Available Shinya Yamazaki, Hiroyoshi Kawaai, Shigeo Sasaki, Kazuhiro Shimamura, Hiroshi Segawa, Takahiro SaitoSpecial Care Department in Dentistry, Ohu University Dental Hospital, Koriyama city, Fukushima prefecture, JapanAbstract: The importance of systemic management to prevent accidents is increasing in dentistry because co-morbid illnesses in an aging society and invasive surgical procedures are increasing. In this prefecture, a new medical system called the remote online hemodynamic monitoring system (ROHMs was started in 2001. Eight private dental offices participated in this trial. When dental practitioners feel the risk of a dental procedure, they can contact via ROHMs to this hospital. Then, the hemodynamic data (blood pressure, heart rate, ECG, SpO2, and RPP of the patient in the clinic can be transmitted here via the internet, and the images and the voice can be transmitted as well. The availability of this system was assessed in 66 patients (98 cases. The most frequent complications were hypertension, heart disease, and diabetes mellitus. Systemic management included monitoring during the dental procedure (71.4%, checking vital signs after an interview (15.3%, and monitoring under sedation (13.3%. There were 35.7% of all cases where an unscheduled procedure was necessary for the systemic management. Based on a questionnaire, the majority of the patients felt relieved and safe. This system creates a situation where a specialist is almost present during the procedure. This system will provide significant assistance for future medical cooperation for risk management.Keywords: online, high-risk patient, dental treatment, medical cooperation, medical accident, risk management

  3. Safety comparison of additives in antiglaucoma prostaglandin (PG analog ophthalmic formulations

    Directory of Open Access Journals (Sweden)

    Fukuda M


    Full Text Available Masamichi Fukuda, Shinsuke Shibata, Naoko Shibata, Kenta Hagihara, Hiromoto Yaguchi, Hiromi Osada, Nobuo Takahashi, Eri Kubo, Hiroshi SasakiDepartment of Ophthalmology, Kanazawa Medical University, Uchinada, JapanPurpose: To investigate the safety of five types of antiglaucoma prostaglandin analog ophthalmic formulations, and to clarify their differences in accordance with contained additives (preservatives and surface-active agents.Methods: The following five types of ophthalmic solutions and three types of additives were investigated: latanoprost (Xalatan®; latanoprost, tafluprost (Tapros®; tafluprost, bimatoprost (Lumigan®; bimatoprost, travoprost (Travatan®; travoprost, travoprost (Travatan Z®; travoprost-Z, benzalkonium chloride (BAK, polyoxyethylene hardening castor oil 40 (HCO-40, and polysorbate 80 (P-80. These experimental solutions were exposed to the cultured cells of a rabbit-derived corneal cell line for a certain time, and the exposure time causing 50% cell damage (CD50, indicated by the ratio of viable cells to total cells was calculated (in vitro. In addition, corneal resistance (CR was measured and CR ratio (post-treatment CR/pretreatment CR × 100 was calculated (in vivo.Results: CD50 of each ophthalmic solution was the longest with tafluprost, followed by travoprost-Z, bimatoprost, travoprost, and latanoprost. CD50 of 0.005%, 0.01%, and 0.02% BAK was 14.5 minutes, 8.1 minutes, and 4.0 minutes, respectively. The number of viable cells decreased to 60%, 8 minutes after exposure with HCO-40, and 30 minutes after being exposed to P-80. The CR ratio was 81.0% with travoprost and 82.0% with latanoprost, indicating a significant posttreatment reduction of CR (P < 0.05. The CR ratio did not decrease after treatment with tafluprost, travoprost-Z, or bimatoprost. The CR ratio of 0.005%, 0.01%, and 0.02% BAK was 105.0%, 90.5%, and 68.7%, respectively, and that of HCO-40 and P-80 was 108.7% and 114.2%, respectively.Conclusion: BAK

  4. Risk assessment tool for incontinence-associated dermatitis in elderly patients combining tissue tolerance and perineal environment predictors: a prospective clinical study

    Directory of Open Access Journals (Sweden)

    Ichikawa-Shigeta Y


    Full Text Available Yoshie Ichikawa-Shigeta,1 Hiromi Sanada,2 Chizuko Konya,3 Saldy Yusuf,1 Supriadi,1 Junko Sugama11Department of Clinical Nursing, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Ishikawa, Japan; 2Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine, University of Tokyo, Tokyo, Japan; 3Department of Adult Nursing, Kanazawa Medical University, Ishikawa, JapanBackground: Elderly patients with incontinence are at risk of developing incontinence-associated dermatitis (IAD. Although perineal risk factors of IAD have been identified, the contribution of tissue tolerance to IAD remains poorly understood.Objective: This study aimed to identify predictors of IAD development in three categories of potential risk factors: perineal environment, tissue tolerance, and toileting ability.Methods: This was a prospective clinical study, conducted at a long-term medical facility in Japan between November 2011 and April 2012. The subjects were elderly female patients with urine and/or fecal incontinence, and constantly wearing absorbent products. The patients were monitored during 42 days for the onset of IAD and the emergence of potential risk factors of IAD related to tissue tolerance (skin hydration status, maceration, erythema index [EI], etc, perineal environment (urination, stool properties, etc, and toileting ability (mobility and cognitive awareness. The risk factors were identified by univariate and multiple logistic regression analysis. Receiver operating characteristic (ROC curve analysis was conducted to evaluate the predictive validity of the risk factors.Results: Among the 46 patients enrolled, IAD developed in 25 (54.3%. The factors significantly associated with IAD development were loose or liquid stools (odds ratio [OR]: 20.612, 95% confidence interval [CI]: 1.118–379.852, P=0.042, malodorous urine (OR: 37.094, 95% CI: 3.480–395.399, P=0.003, and EI ≥46 (OR: 35.191, 95% CI: 5

  5. Objective evaluation for venous leg ulcer-related nociceptive pain using thermography

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    Goto T


    Full Text Available Taichi Goto,1 Ayumi Naito,1,2 Nao Tamai,1 Gojiro Nakagami,1 Makoto Mo,3 Hiromi Sanada1 1Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan; 2Fujisawa City Hospital, Fujisawa, Kanagawa, Japan; 3Department of Cardiovascular Surgery, Yokohama Minami Kyosai Hospital, Yokohama, Kanagawa, Japan Purpose: We aimed to identify distinguishing characteristics in thermographic images of venous leg ulcer (VLU, for objective evaluation of VLU-related nociceptive pain. Patients and methods: Secondary analysis was performed, using existing data obtained from April to November 2010, for patients with VLU. Thermographic images of wounds and their surrounding area were classified according to the periwound temperature pattern as "normal temperature" or "high temperature". These results were compared with the self-reported pain intensity assessed by the short-form McGill Pain Questionnaire. Cohen's kappa coefficients were used to evaluate the interrater reliability for temperature assessment, and Wilcoxon rank sum test was used to compare pain intensities between the two groups. Results: Among 39 thermographic examinations in eight patients, 22 were classified into the high-temperature group and 17 into the normal-temperature group. Kappa coefficients for the temperature classification were 0.90 between the wound, ostomy, and continence nurse and a wound care specialist, and 0.90 between the wound, ostomy, and continence nurse and a graduate student. The pain rating index (Z=−2.981, P=0.003, sensory pain (Z=−3.083, P=0.002, affective pain (Z=−2.764, P=0.006, and present pain intensity (Z=−2.639, P=0.006 ratings were significantly higher in the high-temperature group than in the normal-temperature group, but the visual analog scale (Z=−0.632, P=0.527 was not significantly different between the two groups. Conclusion: Thermographic pattern may reflect VLU

  6. Skin hydration of the heel with fissure in patients with diabetes: a cross-sectional observational study

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    Oe M


    Full Text Available Makoto Oe,1 Kimie Takehara,2 Hiroshi Noguchi,3 Yumiko Ohashi,4 Mayu Fukuda,1 Takashi Kadowaki,5 Hiromi Sanada1,6 1Global Nursing Research Center, 2Department of Advanced Nursing Technology, 3Department of Life Support Technology (Molten, Graduate School of Medicine, The University of Tokyo, 4Department of Nursing, The University of Tokyo Hospital, 5Department of Diabetes and Metabolic Diseases, 6Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan Purpose: Foot fissure should be prevented in patients with diabetes due to the likelihood of subsequent diabetic ulcer. The purpose of this study was to investigate a cutoff point for skin hydration with fissure and the factors associated with low skin hydration in patients with diabetes. Subjects and methods: Subjects were patients with diabetes who visited the diabetic foot clinic and were evaluated for skin hydration on the heel between April 2008 and March 2015. Information about fissure, skin hydration, age, sex, autonomic neuropathy, angiopathy, and tinea pedis were collected from the medical charts. Skin hydration on the heel was measured using a moisture checker. Skin hydration was compared between heels with and without fissure, and a cutoff for skin hydration with fissure was determined using receiver operating characteristic analysis. Based on the determined cutoff, factors associated with lower skin hydration were analyzed using logistic regression analysis. Results: Participants comprised 693 patients. Mean±SD age was 66.8±10.8 years, and 57.0% of subjects were male. The frequency of fissures on the heels was 10.4%. Area under the receiver operating characteristic curve for skin hydration in the presence of fissure was 0.717. Twenty percent was selected as the cutoff point, offering sensitivity of 0.478 and specificity of 0.819. Logistic regression analysis showed correlations between three factors (male sex, tinea

  7. Evaluation of an advanced pressure ulcer management protocol followed by trained wound, ostomy, and continence nurses: a non-randomized controlled trial

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    Kaitani T


    Full Text Available Toshiko Kaitani,1 Gojiro Nakagami,2 Junko Sugama,3 Masahiro Tachi,4 Yutaka Matsuyama,5 Yoshiki Miyachi,6 Takashi Nagase,2 Yukie Takemura,7 Hiromi Sanada2 1School of Nursing, Sapporo City University, Hokkaido, Japan; 2Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; 3Department of Clinical Nursing, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan; 4Department of Plastic Surgery, Tohoku University Graduate School of Medicine, Miyagi, Japan; 5Department of Biostatistics, School of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; 6Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; 7Department of Nursing, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan Aims and objectives: We investigated the effectiveness and safety of an advanced pressure ulcer (PU management protocol comprising 1 ultrasonography to assess the deep tissue, 2 use of a non-contact thermometer to detect critical colonization, 3 conservative sharp debridement, 4 dressing selection, 5 negative pressure wound therapy, and 6 vibration therapy in comparison with those of a conventional approach. Each protocol was followed by trained wound, ostomy, and continence nurses (WOCNs. Background: At present, there is no systematic PU management protocol for nurses that includes appropriate assessment and intervention techniques for deep tissue injury and critical colonization. In Japan, there is no such protocol that the nurses can follow without a physician’s orders. Design and methods: This was a prospective non-randomized controlled trial. Over a 3-week period, we evaluated the effectiveness of an advanced protocol by comparing the PU severity and healing on the basis of the DESIGN-R scale and presence of patients' discomfort. We recruited ten WOCNs to follow

  8. Partial local thermal equilibrium in a low-temperature hydrogen plasma

    International Nuclear Information System (INIS)

    Hey, J.D.; Chu, C.C.; Rash, J.P.S.


    If the degree of ionisation is sufficient, competition between de-excitation by electron collisions and radiative decay determines the smallest principal quantum number (the so-called 'thermal limit') above which partial local thermodynamic equilibrium (PLTE) holds under the particular conditions of electron density and temperature. The LTE (PLTE) criteria of Wilson (JQSRT 1962;2:477-90), Griem (Phys Rev 1963;131:1170-6; Plasma Spectroscopy. New York: McGraw-Hill, 1964), Drawin (Z Physik 1969;228: 99-119), Hey (JQSRT 1976;16:69-75), and Fujimoto and McWhirter (Phys Rev A 1990;42:6588-601) are examined as regards their applicability to neutral atoms. For these purposes, we consider for simplicity an idealised, steady-state, homogeneous and primarily optically thin plasma, with some additional comments and numerical estimates on the roles of opacity and of atom-atom collisions. Particularly for atomic states of lower principal quantum number, the first two of the above criteria should be modified quite appreciably before application to neutral radiators in plasmas of low temperature, because of the profoundly different nature of the near-threshold collisional cross-sections for atoms and ions, while the most recent criterion should be applied with caution to PLTE of atoms in cold plasmas in ionisation balance. (Copyright (c) 1999 Elsevier Science B.V., Amsterdam. All rights reserved.)

  9. Transport coefficients of Dirac ferromagnet: Effects of vertex corrections (United States)

    Fujimoto, Junji


    As a strongly spin-orbit-coupled metallic model with ferromagnetism, we have considered an extended Stoner model to the relativistic regime, named Dirac ferromagnet in three dimensions. In a previous paper [J. Fujimoto and H. Kohno, Phys. Rev. B 90, 214418 (2014), 10.1103/PhysRevB.90.214418], we studied the transport properties giving rise to the anisotropic magnetoresistance (AMR) and the anomalous Hall effect (AHE) with the impurity potential being taken into account only as the self-energy. The effects of the vertex corrections (VCs) to AMR and AHE are reported in this paper. AMR is found not to change quantitatively when the VCs are considered, although the transport lifetime is different from the one-electron lifetime and the charge current includes additional contributions from the correlation with spin currents. The side-jump and the skew-scattering contributions to AHE are also calculated. The skew-scattering contribution is dominant in the clean case as can be seen in the spin Hall effect in the nonmagnetic Dirac electron system.

  10. Cine-Club

    CERN Multimedia



    Lundi 12 décembre 2011 à 18:30 Salle du Conseil Comme chaque année avant Noël, le CINE-CLUB du CERN est heureux d’inviter petits et grands à une projection gratuite du film : Ponyo sur la falaise (Japon, 2008, Hayao Miyazaki) Le petit Sosuke vit avec sa mère sur une haute falaise surplombant la mer. Un beau jour, il découvre sur la plage caillouteuse Ponyo, une petite fille poisson. Ponyo est si fascinée par Sosuke et le monde terrestre que son désir le plus cher est de devenir un être humain. Mais Fujimoto, son magicien de père, n’est pas du tout d’accord avec cette idée et il la force à regagner les profondeurs de l’océan. Bien décidée à revoir Sosuke, Ponyo s’échappe de sa prison sous-marine, mais ce faisant elle déclenche une immense catastroph...

  11. A case of anterior ischemic optic neuropathy associated with uveitis

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    Sugahara M


    Full Text Available Michitaka Sugahara, Takayuki Fujimoto, Kyoko Shidara, Kenji Inoue, Masato Wakakura Inouye Eye Hospital, Tokyo, Japan Introduction: Here, we describe a patient who presented with anterior ischemic optic neuropathy (AION and subsequently developed uveitis. Case: A 69-year-old man was referred to our hospital and initially presented with best-corrected visual acuities (BCVA of 20/40 (right eye and 20/1000 (left eye and relative afferent pupillary defect. Slit-lamp examination revealed no signs of ocular inflammation in either eye. Fundus examination revealed left-eye swelling and a pale superior optic disc, and Goldmann perimetry revealed left-eye inferior hemianopia. The patient was diagnosed with nonarteritic AION in the left eye. One week later, the patient returned to the hospital because of vision loss. The BCVA of the left eye was so poor that the patient could only count fingers. Slit-lamp examination revealed 1+ cells in the anterior chamber and the anterior vitreous in both eyes. Funduscopic examination revealed vasculitis and exudates in both eyes. The patient was diagnosed with bilateral panuveitis, and treatment with topical betamethasone was started. No other physical findings resulting from other autoimmune or infectious diseases were found. No additional treatments were administered, and optic disc edema in the left eye improved, and the retinal exudates disappeared in 3 months. The patient's BCVA improved after cataract surgery was performed. Conclusion: Panuveitis most likely manifests after the development of AION. Keywords: anterior ischemic optic neuropathy, uveitis

  12. Effect of uracil on the intracellular distribution of 1-(2-tetrahydrofuryl)-5-fluorouracil in the mouse tumor cells

    Energy Technology Data Exchange (ETDEWEB)

    Fujimoto, J.; Kosaki, G. (Osaka Univ. (Japan). Faculty of Medicine)


    Fifteen 1-(2-tetrahydrofuryl)-5-fluoro (-6-/sup 3/H) uracil (/sup 3/H-FT) were injected i.p. into mice bearing Fujimoto ascites tumor. Tumor cells were removed at various intervals and the autoradiographs were prepared. The specimens were treated first with chloroform before being coated with emulsion, so as to remove /sup 3/H-FT in the specimens and to preserve 5-fluoro (-6-/sup 3/H) uracil (/sup 3/H-FU) which was released from /sup 3/H-FT. Autoradiographs revealed a higher concentration of silver grains which localized over the nucleus, especially over the nucleoli, of tumor cells than over the cytoplasm. When 33.6 uracil/g was coadministered with 15.0 /sup 3/H-FT/g into tumor-bearing mice, intracellular distribution of /sup 3/H-FU released from /sup 3/H-FT was unchanged and an incorporation of /sup 3/H-FU into the tumor cells was higher than when /sup 3/H-FT alone.

  13. Cine club

    CERN Multimedia

    Ciné club


    Monday 13 December 2010 at 18:30 / Lundi 13 Décembre 2010 à 18:30 CERN Main Auditorium / Amphithéâtre Principal Comme chaque année avant Noël, le CINE-CLUB du CERN est heureux d’inviter petits et grands à une projection gratuite du film.   Ponyo sur la falaise (Japon, 2008, Hayao Miyazaki) Le petit Sosuke vit avec sa mère sur une haute falaise surplombant la mer. Un beau jour, il découvre sur la plage caillouteuse Ponyo, une petite fille poisson. Ponyo est si fascinée par Sosuke et le monde terrestre que son désir le plus cher est de devenir un être humain. Mais Fujimoto, son magicien de père, n’est pas du tout d’accord avec cette idée et il la force à regagner les profondeurs de l’océan. Bien décidée à revoir Sosuke, Ponyo s’&...

  14. Minimalism in architecture: Abstract conceptualization of architecture

    Directory of Open Access Journals (Sweden)

    Vasilski Dragana


    Full Text Available Minimalism in architecture contains the idea of the minimum as a leading creative tend to be considered and interpreted in working through phenomena of empathy and abstraction. In the Western culture, the root of this idea is found in empathy of Wilhelm Worringer and abstraction of Kasimir Malevich. In his dissertation, 'Abstraction and Empathy' Worringer presented his thesis on the psychology of style through which he explained the two opposing basic forms: abstraction and empathy. His conclusion on empathy as a psychological basis of observation expression is significant due to the verbal congruence with contemporary minimalist expression. His intuition was enhenced furthermore by figure of Malevich. Abstraction, as an expression of inner unfettered inspiration, has played a crucial role in the development of modern art and architecture of the twentieth century. Abstraction, which is one of the basic methods of learning in psychology (separating relevant from irrelevant features, Carl Jung is used to discover ideas. Minimalism in architecture emphasizes the level of abstraction to which the individual functions are reduced. Different types of abstraction are present: in the form as well as function of the basic elements: walls and windows. The case study is an example of Sou Fujimoto who is unequivocal in its commitment to the autonomy of abstract conceptualization of architecture.

  15. Interior-exterior connection in architectural design based on the incorporation of spatial in between layers. Study of four architectural projects

    Directory of Open Access Journals (Sweden)

    Krstić Hristina


    Full Text Available Different spatial layers in the architectural structure of a building can create particular spatial relations and an architectural space that cannot be defined as an inner space or as an outer space, but one which has the characteristics of both. This space, which can be called “in between space”, appears as the result of a specific design concept in which the architectural composition is created by gradual insertion of volumes one inside another, like a box that is placed inside a box, inside of which is placed another smaller box and so on. The incorporation of various layers in the spatial arrangement of volumes in certain architectural compositions can be conceived as a possible approach in connecting the interior and exterior. This kind of conceptual design distinguishes itself from the common approach by its specific architecture that offers richness, variety, complexity and unique perception of space, thereby increasing its value. The paper investigates this particular concept through the analysis of four residential houses (Villa Le Lac by Le Corbusier, Solar House by Oswald Mathias Ungers, House N by Sou Fujimoto and Guerrero House by Alberto Campo Baeza, and it strives to find out the concept’s use and advantages, all with the aim of opening up new possibilities in the design of buildings and enriching the design process.

  16. The 24-hour intraocular pressure control by tafluprost/timolol fixed combination after switching from the concomitant use of tafluprost and timolol gel-forming solution, in patients with primary open-angle glaucoma

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    Nakamoto K


    Full Text Available Kenji Nakamoto,1 Masahiko Takeshi,2 Toshihiko Hiraoka,2,3 Mayuko Eguchi,2,4 Yuichiro Nakano,1,2 Naomi Otsuka,5 Hiroko Hizaki,5 Hiromi Akai,5 Masayo Hashimoto5 1Department of Ophthalmology, Nippon Medical School, Tokyo, Japan; 2Shinanozaka Clinic, Tokyo, Japan; 3Hiraoka Eye Clinic, Saitama, Japan; 4Musashiurawa Eye Clinic, Saitama, Japan; 5Japan Medical Affairs, Global R&D, Santen Pharmaceutical Co., Ltd., Osaka, Japan Objective: The aim of this study was to evaluate the 24-hour intraocular pressure (IOP-control effect of the tafluprost/timolol fixed combination (TAF/TIM-FC in patients with primary open-angle glaucoma after they switched from the concomitant use of tafluprost and timolol gel-forming solution. Patients and methods: Twenty patients with primary open-angle glaucoma (12 male and 8 female; mean ± SD age, 57.0±7.1 years were included in this study. The patients were treated for 8 weeks with the concomitant administration of tafluprost and timolol gel-forming solution (evening dosing. At the end of this period, the patients underwent 24-hour IOP monitoring (measured at 21:00, 01:00, 05:00, 09:00, 13:00 and 17:00. IOP was measured with Goldmann applanation tonometer (GAT and Icare PRO at sitting position at all timepoints and additionally, at supine position with Icare PRO tonometer at 01:00 and 05:00. The patients were then all switched to TAF/TIM-FC treatment (evening dosing. After 8 weeks, the 24-hour IOP monitoring was repeated. Results: Nineteen patients completed the study. The mean 24-hour IOPs in the concomitant and TAF/TIM-FC phases were 13.8±2.7 vs 13.3±2.8 mmHg (P=0.0033 with the GAT in the sitting position and 13.96±2.56 vs 13.48±2.56 mmHg (P=0.0120 with the Icare PRO in habitual positions. In comparison with the concomitant phase, significantly lower IOP was observed for the TAF/TIM-FC phase at 21:00 and 01:00 with the GAT and at 01:00 with the Icare PRO. In addition, the maximum IOP and fluctuations in IOP in

  17. Amount of nutrients in stalk of sugar cane as a function of sources and doses of manganeseAcúmulo de nutrientes no colmo de cana-de-açúcar em função de fontes e doses de manganês

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    Cleiton Gredson Sabin Benett


    Full Text Available The low productivity of sugarcane crop in some areas can be correlated with the lack of nutrients due to cane sugar crop be a major exporter of nutrients. The objective this study was to evaluate the effect of five doses and three sources of manganese applied in the planting furrow in sugar cane plant and its residual effects on ratoon cane, in the northwest region of São Paulo. The experiment was conducted at the site Fujimoto, area administered by the Valley Distillery Parana S/A Sugar and Alcohol in Suzanápolis – SP. The experimental design was randomized blocks in a factorial scheme 5x3, with five doses of manganese (0, 2.5, 5.0, 7.5 and 10.0 kg ha-1 and three sources (sulfate, chelate and FTE, applied at planting furrow in 4 repetitions. The plots consisted of four rows 5 m long, spaced by 1.5 m. The variety used was RB 86-7515. We assessed the accumulation of macro and micronutrients in stems, dry matter yield of stalks and stems. The sources and doses of manganese influenced the accumulation of macro and micronutrients and the dry stalks of sugar cane plant and ratoon cane. The stalk productivity was not affected by doses and sources of manganese in any crops. A baixa produtividade dos canaviais em algumas áreas pode estar relacionada a exigência e exportação da cultura da cana-de-açúcar. O objetivo deste estudo foi avaliar o efeito de cinco doses e três fontes de manganês aplicadas no sulco de plantio na cultura da cana-de-açúcar em cana planta e seu efeito residual em cana soca. O experimento foi conduzido no sítio Fujimoto, área administrada pela Destilaria Vale do Paraná S/A Álcool e Açúcar, no município de Suzanápolis – SP. O delineamento experimental utilizado foi o de blocos ao acaso arranjado em esquema fatorial 5x3, sendo cinco doses de manganês (0; 2,5; 5,0; 7,5 e 10,0 kg ha-1 e três fontes (sulfato de manganês, quelato e FTE BR 12, aplicadas no sulco de plantio, com 4 repetições. As parcelas foram

  18. PREFACE: International Conference on Advanced Structural and Functional Materials Design 2008 (United States)

    Kakeshita, Tomoyuki


    related research topics. The organizing committee gratefully thanks participants for presenting their recent results and for discussions with our COE members and international attendees. November 2008 Professor Tomoyuki Kakeshita Chairman of the Conference Vice Dean, Graduate School of Engineering, Osaka University, Division of Materials and Manufacturing Science, Graduate School of Engineering Leader of Global COE Program, Osaka University, ''Center of Excellence for Advanced Structural and Functional Materials Design'' Organization Chairman: T Kakeshita (Osaka University) Advisory Board:H Mehrer (University Münster, Germany), E K H Salje (University of Cambridge, United Kingdom), H-E Schaefer (University of Stuttgart, Germany), P Veyssiere (CNRS-ONERA, France) Organizing Committee: T Kakeshita, H Araki, H Fujii, S Fujimoto, Y Fujiwara, A Hirose, S Kirihara, M Mochizuki, H Mori, T Nagase, H Nakajima, T Nakano, R Nakatani, K Nogi, Y Setsuhara, Y Shiratsuchi, T Tanaka, T Terai, H Tsuchiya, N Tsuji, H Utsunomiya, H Yasuda, H Yasuda (Osaka University) Executive Committee: T Kakeshita, S Fujimoto, Y Fujiwara, A Hirose, T Tanaka, H Yasuda (Osaka University) Conference Secretariat: Y Fujiwara (Osaka University) Proceedings Editors: T Kakeshita and Y Fujiwara (Osaka University) Conference photograph

  19. Efficacy of tiotropium and indacaterol monotherapy and their combination on dynamic lung hyperinflation in COPD: a random open-label crossover study

    Directory of Open Access Journals (Sweden)

    Fujimoto K


    Full Text Available Keisaku Fujimoto,1 Haruna Yamazaki,2 Midori Ura,2 Yoshiaki Kitaguchi3 1Department of Clinical Laboratory Sciences, School of Health Sciences, 2Department of Biomedical Laboratory Science, Graduate School of Medicine, 3First Department of Internal Medicine, School of Medicine, Shinshu University, Matsumoto, Japan Background and objective: The difference in efficacy of long-acting muscarinic antagonists (LAMAs and long-acting β2-agonists (LABAs for dynamic lung hyperinflation (DLH in COPD is unclear. The purpose of this study was to elucidate the difference in efficacy of LAMA and LABA alone and the combination thereof for DLH. Subjects and methods: Thirty stable patients were enrolled and randomly divided into two groups following baseline measurements. One group was treated with 5 µg tiotropium (Respimat inhaler for 4 weeks following a 4-week treatment with 150 µg indacaterol, while the other group was treated with indacaterol for 4 weeks following a 4-week treatment with tiotropium. For both groups, these treatments were followed by a combination of the two drugs for 4 weeks. Pulmonary function tests, including DLH evaluated by metronome-paced incremental hyperventilation and exercise tolerance evaluated by the shuttle-walk test, were performed at the end of each treatment period. Results: In total, 23 patients completed this study. Both tiotropium and indacaterol alone significantly increased forced expiratory volume in 1 second, exercise tolerance, and improved health status. Tiotropium significantly improved DLH, but indacaterol did not. The combination therapy resulted in further improvements in lung function and exercise tolerance, but not in DLH. Conclusion: The efficacy of tiotropium in inhibiting DLH following metronome-paced incremental hyperventilation may be superior to that of 150 µg indacaterol, although the effects on airflow obstruction were the same, and the combination therapy showed further improvement in airflow

  20. Comparison of efficacy of long-acting bronchodilators in emphysema dominant and emphysema nondominant chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Fujimoto K


    Full Text Available Keisaku Fujimoto1, Yoshiaki Kitaguchi2, Shintaro Kanda2, Kazuhisa Urushihata2, Masayuki Hanaoka2, Keishi Kubo21Department of Biomedical Laboratory Sciences, 2First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, JapanBackground: The purpose of this study was to clarify the association between morphological phenotypes according to the predominance of emphysema and efficacy of long-acting muscarinic antagonist and β2 agonist bronchodilators in patients with chronic obstructive pulmonary disease (COPD.Methods: Seventy-two patients with stable COPD treated with tiotropium (n = 41 or salmeterol (n = 31 were evaluated for pulmonary function, dynamic hyperinflation following metronome-paced incremental hyperventilation, six-minute walking distance, and St George’s Respiratory Questionnaire (SGRQ before and 2–3 months following treatment with tiotropium or salmeterol. They were then visually divided into an emphysema dominant phenotype (n = 25 in the tiotropium-treated group and n = 22 in the salmeterol-treated group and an emphysema nondominant phenotype on high-resolution computed tomography, and the efficacy of the two drugs in each phenotype was retrospectively analyzed.Results: Tiotropium significantly improved airflow limitation, oxygenation, and respiratory impedance in both the emphysema dominant and emphysema nondominant phenotypes, and improved dynamic hyperinflation, exercise capacity, and SGRQ in the emphysema dominant phenotype but not in the emphysema nondominant phenotype. Salmeterol significantly improved total score for SGRQ in the emphysema phenotype, but no significant effects on other parameters were found for either of the phenotypes.Conclusion: These findings suggest that tiotropium is more effective than salmeterol for airflow limitation regardless of emphysema dominance, and also can improve dynamic hyperinflation in the emphysema dominant phenotype, which results in further

  1. Evaluation of dacryocystorhinostomy using optical coherence tomography and rebamipide ophthalmic suspension

    Directory of Open Access Journals (Sweden)

    Fujimoto M


    Full Text Available Masahiro Fujimoto,1 Ken Ogino,1 Chika Miyazaki,1,2 Miou Hirose,1,3 Hiroko Matsuyama,1,4 Takeshi Moritera,1,5 Nagahisa Yoshimura1 1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan; 2Department of Ophthalmology, Hyogo Prefectural Tsukaguchi Hospital, Hyogo, Japan; 3Department of Ophthalmology, Hyogo Prefectural Amagasaki Hospital, Hyogo, Japan; 4Department of Ophthalmology, National Hospital Organization Himeji Medical Center, Hyogo, Japan; 5Moritera Eye Clinic, Shiga, Japan Purpose: To evaluate the surgical outcome of dacryocystorhinostomy (DCR by measuring the tear meniscus, using optical coherence tomography and rebamipide ophthalmic suspension. Methods: Patients with nasolacrimal obstruction and chronic dacryocystitis who were scheduled for an endonasal DCR underwent tear meniscus examinations before and 2 months after surgery. Vertical scans of the inferior menisci were performed before and at 1, 3, 5, 7, and 10 minutes after the instillation of rebamipide ophthalmic suspension. The tear menisci areas were measured with imaging software. Ten young adults without epiphora formed the control group.Results: Anatomical success was achieved on 22 sides of 21 patients. The patients’ postoperative tear menisci were significantly smaller than the preoperative menisci at all points during the test, and the response to volume loading in the postoperative patients was corrected to nearly that of the young, healthy adults. Nevertheless, the postoperative meniscus area tended to be larger than that of the young adults at all points.Conclusion: The reduced tear meniscus area after DCR reflected the success of the surgical procedure. However, incomplete recovery of the meniscus after the test might suggest a residual disorder of the lacrimal drainage system after DCR. Keywords: dacryocystorhinostomy, tear meniscus, rebamipide, optical coherence tomography

  2. Randomized Phase II trial of paclitaxel plus valproic acid vs paclitaxel alone as second-line therapy for patients with advanced gastric cancer

    Directory of Open Access Journals (Sweden)

    Fushida S


    Full Text Available Sachio Fushida,1 Masahide Kaji,2 Katsunobu Oyama,1 Yasuo Hirono,3 Hideaki Nezuka,4 Toshiya Takeda,5 Tomoya Tsukada,1 Daisuke Fujimoto,3 Shigekazu Ohyama,6 Takashi Fujimura,7 Tetsuo Ohta1 On behalf of the Digestive Disease Support Organization (DDSO 1Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, 2Department of Surgery, Toyama Prefectural Central Hospital, Toyama, 3First Department of Surgery, Fukui University Hospital, Fukui, 4Department of Surgery, Yatsuo General Hospital, Toyama, 5Department of Surgery, Ishikawa Matto Central Hospital, Hakusan, 6Department of Surgery, Kanazawa Medical Center, Kanazawa, 7Toyama City Hospital, Toyama, Japan Abstract: The standard regimen of second-line chemotherapy for patients with unresectable gastric cancer has not been established. However, weekly paclitaxel (wPTX has become the preferable second-line chemotherapy in Japan. Histone deacetylase (HDAC inhibitors have been shown to have antiproliferative activity through cell-cycle arrest, differentiation, and apoptosis in gastric cancer cells. One HDAC inhibitor, valproic acid (VPA, also inhibits tumor growth by inducing apoptosis, and enhances the efficacy of paclitaxel in a mouse xenograft model of gastric cancer. wPTX plus VPA as a second-line chemotherapy is expected to improve survival in gastric cancer patients. A multicenter randomized Phase II study was conducted to compare the effects of wPTX plus VPA and wPTX alone. A total of 66 patients participated in this study. The primary end point of the study was overall survival, and secondary end points were progression-free survival, response rate, and assessment of peripheral neuropathy. Keywords: valproic acid, paclitaxel, second-line therapy, advanced gastric cancer 

  3. Collisional-radiative model for neutral helium in plasma. Excitation cross section and singlet-triplet wavefunction mixing

    Energy Technology Data Exchange (ETDEWEB)

    Goto, Motoshi [National Inst. for Fusion Science, Toki, Gifu (Japan); Fujimoto, Takashi


    We have revised the collisional-radiative (CR) model code of neutral helium (T. Fujimoto, JQSRT 21, 1979). The spin-orbit interaction gives rise to mixing of the wavefunctions of the singlet and triplet states. The degree of the mixing depends on the magnetic field, and at the field strength of the level-anticrossings complete mixing, or complete breakdown of the L-S coupling scheme, occurs. We have approximately incorporated this effect into the code. We have reviewed the excitation cross section data for electron impacts. For transitions starting from the ground state, the recent assessment by the group led by Dr. de Heer is judged satisfactory. For transitions from the metastable levels the assessment by the same group appears rather conservative; there remains a question about the cross section values near the threshold. For transitions between different-l levels within the same multiplicity and same n, a semi-empirical formula based on the Born cross section gives a good agreement with experiment. Proton impacts are also considered for these transitions. We compare the new cross sections with those used in the original version. These cross sections for transitions starting from the metastable levels are fitted by analytical formulas and the parameter values are given. We also give parameter values for the excitation rate coefficient for these transitions as well as for transitions starting from the ground state. With all the above revisions incorporated into the CR model code, we have calculated the energy loss rates and the line intensity ratios for the purpose of plasma diagnostics, where the effect of a magnetic field is noted. The calculated population distribution over excited levels are compared with experiment, and a tentative conclusion is drawn concerning the excitation cross section from the metastable level. (author)

  4. Alianzas y redes de colaboración entre las agrupaciones culturales de las Artes Escénicas en Andalucía

    Directory of Open Access Journals (Sweden)

    I. Ramos


    Full Text Available el análisis de redes sociales se ha utilizado de manera efectiva en la evalua- ción de programas (eisenberg & swanson, 1996; Fujimoto, valente & Pentz, 2009, la gestión de información y la difusión de innovaciones (valente, 1995; Kraatz, 1998; ahuja, 2000, el estudio de la evolución de las coaliciones comu- nitarias (Feinberg, Riggs & greenberg, 2005; Wendel et al., 2010 y las iniciati- vas para promover la capacidad de las organizaciones (nowel & Foster-Fishman, 2010. en este estudio se analizan 6 tipos de relaciones entre 32 organizaciones culturales del sector de las artes escénicas en andalucía. las agrupaciones de las artes escénicas en andalucía conforman una estructura centro-periferia. el es- pacio central se articula en torno a una tríada formada por tres entidades jóvenes que destacan, respectivamente, por (a gestionar recursos de formación en artes escénicas, (b coordinar la asociación de los profesionales del sector y (c tener un perfil activo en la producción de espectáculos en los últimos años. a través del análisis de clúster han sido identificados cuatro conglomerados integrados por organizaciones que han desplegado diferentes estrategias relacionales y cuentan con características diferenciales. los resultados se devolvieron a repre- sentantes del sector en un grupo de discusión. se presentan las reacciones de los participantes.

  5. Mechanism-based fluorescent labeling of beta-galactosidases. An efficient method in proteomics for glycoside hydrolases. (United States)

    Kurogochi, Masaki; Nishimura, Shin-Ichiro; Lee, Yuan Chuan


    (4-N-5-Dimethylaminonaphthalene-1-sulfonyl-2-difluoromethylphenyl)-beta-d-galactopyranoside was synthesized and successfully tested on beta-galactosidases from Xanthomonas manihotis (Wong-Madden, S. T., and Landry, D. Glycobiology (1995) 5, 19-28 and Taron, C. H., Benner, J. S., Hornstra, L. J., and Guthrie, E. P. (1995) Glycobiology 5, 603-610), Escherichia coli (Jacobson, R. H., Zhang, X. J., DuBose, R. F., and Matthews, B. W. (1994) Nature 369, 761-766), and Bacillus circulans (Fujimoto, H., Miyasato, M., Ito, Y., Sasaki, T., and Ajisaka, K. (1988) Glycoconj. J. 15, 155-160) for the rapid identification of the catalytic site. Reaction of the irreversible inhibitor with enzymes proceeded to afford a fluorescence-labeled protein suitable for further high throughput characterization by using antidansyl antibody and matrix-assisted laser desorption ionization time-of-flight/time-of-flight (MALDI-TOF/TOF). Specific probing by a fluorescent aglycon greatly facilitated identification of the labeled peptide fragments from beta-galactosidases. It was demonstrated by using X. manihotis beta-galactosidase that the Arg-58 residue, which is located within a sequence of 56IPRAYWKD63, was labeled by nucleophilic attack of the guanidinyl group. This sequence including Arg-58 (Leu-46 to Tyr-194) was similar to that (Met-1 to Tyr-151) of Thermus thermophilus A4, which is the first known structure of glycoside hydrolases family 42 (Hidaka, M., Fushinobu, S., Ohtsu, N., Motoshima, H., Matsuzawa, H., Shoun, H., and Wakagi, T. (2002) J. Mol. Biol. 322, 79-91). A catalytic glutamic acid (Glu-537) of E. coli beta-galactosidase was proved to be labeled by the same procedure, suggesting that the modification site with this irreversible substrate might depend both on the nucleophilicity of the amino acids and their spatial arrangement in the individual catalytic cavity. Similarly, a Glu-259 in 257TLEE260 was selectively labeled using B. circulans beta-galactosidase, indicating that Glu

  6. Sputum eosinophilia can predict responsiveness to inhaled corticosteroid treatment in patients with overlap syndrome of COPD and asthma

    Directory of Open Access Journals (Sweden)

    Kubo K


    Full Text Available Yoshiaki Kitaguchi1,*, Yoshimichi Komatsu1,*, Keisaku Fujimoto2, Masayuki Hanaoka1, Keishi Kubo1 1First Department of Internal Medicine, Shinshu University School of Medicine, 2Department of Biomedical Laboratory Sciences, Shinshu University School of Health Sciences, Matsumoto, Japan *These authors contributed equally to this workBackground: Chronic obstructive pulmonary disease (COPD and asthma may overlap and converge in older people (overlap syndrome. It was hypothesized that patients with overlap syndrome may have different clinical characteristics such as sputum eosinophilia, and better responsiveness to treatment with inhaled corticosteroid (ICS.Methods: Sixty-three patients with stable COPD (forced expiratory volume in 1 second [FEV1] ≤80% underwent pulmonary function tests, including reversibility of airflow limitation, arterial blood gas analysis, analysis of inflammatory cells in induced sputum, and chest high-resolution computed tomography. The inclusion criteria for COPD patients with asthmatic symptoms included having asthmatic symptoms such as episodic breathlessness, wheezing, cough, and chest tightness worsening at night or in the early morning (COPD with asthma group. The clinical features of COPD patients with asthmatic symptoms were compared with those of COPD patients without asthmatic symptoms (COPD without asthma group.Results: The increases in FEV1 in response to treatment with ICS were significantly higher in the COPD with asthma group. The peripheral eosinophil counts and sputum eosinophil counts were significantly higher. The prevalence of patients with bronchial wall thickening on chest high-resolution computed tomography was significantly higher. A significant correlation was observed between the increases in FEV1 in response to treatment with ICS and sputum eosinophil counts, and between the increases in FEV1 in response to treatment with ICS and the grade of bronchial wall thickening. Receiver operating

  7. Pulmonary function impairment in patients with combined pulmonary fibrosis and emphysema with and without airflow obstruction

    Directory of Open Access Journals (Sweden)

    Kitaguchi Y


    Full Text Available Yoshiaki Kitaguchi,1,2 Keisaku Fujimoto,3 Masayuki Hanaoka,1 Takayuki Honda,4 Junichi Hotta,2 Jiro Hirayama2 1First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, 2Department of Internal Medicine, Okaya City Hospital, Okaya, 3Department of Clinical Laboratory Sciences, 4Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan Background: The syndrome of combined pulmonary fibrosis and emphysema (CPFE is a recently described entity associating upper-lobe emphysema and lower-lobe fibrosis. We sought to evaluate differences in pulmonary function between CPFE patients with and without airflow obstruction. Subjects and methods: Thirty-one CPFE patients were divided into two groups according to the presence or absence of irreversible airflow obstruction based on spirometry (forced expiratory volume in 1 second/forced vital capacity <70% following inhalation of a β2-agonist as follows: CPFE patients with airflow obstruction (CPFE OB+ group, n=11, and CPFE patients without airflow obstruction (CPFE OB– group, n=20. Pulmonary function, including respiratory impedance evaluated using impulse oscillometry and dynamic hyperinflation following metronome-paced incremental hyperventilation, was retrospectively analyzed in comparison with that observed in 49 chronic obstructive pulmonary disease (COPD patients (n=49. Results: In imaging findings, low-attenuation-area scores on chest high-resolution computed tomography, representing the degree of emphysema, were significantly lower in the CPFE OB– group than in the CPFE OB+ and COPD groups. In contrast, the severity of pulmonary fibrosis was greater in the CPFE OB– group than in the CPFE OB+ group. In pulmonary function, lung hyperinflation was not apparent in the CPFE OB– group. Impairment of diffusion capacity was severe in both the CPFE OB– and CPFE OB+ groups. Impulse oscillometry showed that respiratory resistance was not

  8. Patient perspectives on Parkinson’s disease therapy in Japan and the United States: results of two patient surveys

    Directory of Open Access Journals (Sweden)

    Hattori N


    Full Text Available Nobutaka Hattori,1 Kenichi Fujimoto,2 Tomoyoshi Kondo,3 Miho Murata,4 Mark Stacy51Department of Neurology, Juntendo University School of Medicine, Tokyo; 2Department of Neurology, Jichi Medical University, Tochigi; 3Department of Neurology, Wakayama Medical University, Wakayama; 4Department of Neurology, National Center Hospital of Neurology and Psychiatry, Tokyo, Japan; 5Division of Neurology, Duke University, Durham, NC, USABackground: Despite evidence suggesting that patient attitudes towards therapy may influence treatment outcomes, the impact of these factors on treatment for Parkinson’s disease is poorly understood. These two surveys, based in Japan and the US, investigated the attitudes of patients towards antiparkinsonian medications, the complications of these therapies, and how these differ across geographies.Methods: The US PRELUDE survey collected data from May 13 to May 20, 2003, from 300 interviews with patients with Parkinson’s disease from the National Parkinson Foundation. The Japanese survey was carried out from June to December 2008 in a stepwise manner using questionnaires (n = 3548 followed by interviews with those who had consented to participate in the questionnaire (n = 407. Both surveys assessed the attitudes of patients towards therapies for Parkinson’s disease and associated complications.Results: Dyskinesia was not a major challenge of therapy for Parkinson’s disease, and wearing-off caused greater concern in the US, while hallucinations had a greater emphasis in Japan. Patients who had previously experienced dyskinesia were less concerned about this side effect than those who had not. Although pill burden was thought to be a concern in the US, Japanese patients did not indicate that pill burden would limit their drug intake. There were also discrepancies between the perspectives and concerns of patients and those of their treating physicians.Conclusion: Recognizing patient perspectives regarding therapies for

  9. Analysis of detached recombining plasmas by collisonal-radiative model with energetic electron component

    International Nuclear Information System (INIS)

    Ohno, N.; Motoyama, M.; Takamura, S.


    using CR model for a helium plasma (Goto-Fujimoto code), in which the energetic electron component (electron beam) is taken into account in addition to the bulk electron Maxwellian distribution function. It is found that the evaluated bulk electron temperature with the method of Boltzmann plot tends to decrease with an increase in the electron beam density and/or energy because the population densities in relatively lower excited states become large, comparing with those in higher excited state. This result agrees with the experimental observations. We have also analyzed transition of recombining plasma to ionizing one and vice versa in detail. This analysis can reproduce the inverse ELM phenomena observed in JET and ASDEX-U. (orig.)

  10. Usefulness of the 6-minute walk test as a screening test for pulmonary arterial enlargement in COPD

    Directory of Open Access Journals (Sweden)

    Oki Y


    Full Text Available Yutaro Oki,1,2 Masahiro Kaneko,3 Yukari Fujimoto,1 Hideki Sakai,2 Shogo Misu,1,2 Yuji Mitani,1,4 Takumi Yamaguchi,1,2 Hisafumi Yasuda,1 Akira Ishikawa1 1Department of Community Health Sciences, Kobe University Graduate School of Health Sciences, 2Department of Rehabilitation, 3Department of Respiratory Medicine, Kobe City Medical Center West Hospital, Kobe, 4Department of Rehabilitation, Sapporo Nishimaruyama Hospital, Sapporo, Japan Purpose: Pulmonary hypertension and exercise-induced oxygen desaturation (EID influence acute exacerbation of COPD. Computed tomography (CT-detected pulmonary artery (PA enlargement is independently associated with acute COPD exacerbations. Associations between PA to aorta (PA:A ratio and EID in patients with COPD have not been reported. We hypothesized that the PA:A ratio correlated with EID and that results of the 6-minute walk test (6MWT would be useful for predicting the risk associated with PA:A >1.Patients and methods: We retrospectively measured lung function, 6MWT, emphysema area, and PA enlargement on CT in 64 patients with COPD. The patients were classified into groups with PA:A ≤1 and >1. Receiver-operating characteristic curves were used to determine the threshold values with the best cutoff points to predict patients with PA:A >1.Results: The PA:A >1 group had lower forced expiratory volume in 1 second (FEV1, forced vital capacity (FVC, FEV1:FVC ratio, diffusion capacity of lung carbon monoxide, 6MW distance, and baseline peripheral oxygen saturation (SpO2, lowest SpO2, highest modified Borg scale results, percentage low-attenuation area, and history of acute COPD exacerbations ≤1 year, and worse BODE (Body mass index, airflow Obstruction, Dyspnea, and Exercise index results (P<0.05. Predicted PA:A >1 was determined for SpO2 during 6MWT (best cutoff point 89%, area under the curve 0.94, 95% confidence interval 0.88–1. SpO2 <90% during 6MWT showed a sensitivity of 93.1, specificity of 94

  11. Choroidal thinning in high myopia measured by optical coherence tomography

    Directory of Open Access Journals (Sweden)

    Ikuno Y


    Full Text Available Yasushi Ikuno, Satoko Fujimoto, Yukari Jo, Tomoko Asai, Kohji NishidaDepartment of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, JapanPurpose: To investigate the rate of choroidal thinning in highly myopic eyes.Patients and methods: A retrospective observational study of 37 eyes of 26 subjects (nine males and 17 females, mean age 39.6 ± 7.7 years with high myopia but no pathologies who had undergone spectral domain optical coherence tomography and repeated the test 1 year later (1 ± 0.25 year at Osaka University Hospital, Osaka, Japan. Patients older than 50 years with visual acuity worse than 20/40 or with whitish chorioretinal atrophy involving the macula were excluded. Two masked raters measured the choroidal thicknesses (CTs at the foveda, 3 mm superiorly, inferiorly, temporally, and nasally on the images and averaged the values. The second examination was about 365 days after the baseline examination. The CT reduction per year (CTRPY was defined as (CT 1 year after - baseline CT/days between the two examinations × 365. The retinal thicknesses were also investigated.Results: The CTRPY at the fovea was −1.0 ± 22.0 µm (range –50.2 to 98.5 at the fovea, –6.5 ± 24.3 µm (range −65.8 to 90.2 temporally, –0.5 ± 22.3 µm (range –27.1 to 82.5 nasally, –9.7 ± 21.7 µm (range –40.1 to 60.1 superiorly, and –1.4 ± 25.5 µm (range –85.6 to 75.2 inferiorly. There were no significant differences in the CTRPY at each location (P = 0.34. The CT decreased significantly (P < 0.05 only superiorly. The superior CTRPY was negatively correlated with the axial length (P < 0.05. The retinal thickness at the fovea did not change. Stepwise analysis for CTRPY selected axial length (P = 0.04, R2 = 0.13 and age (P = 0.08, R2 = 0.21 as relevant factors.Conclusions: The highly myopic choroid might gradually thin and be affected by many factors. Location and axial length are key factors to regulate the rate of choroidal

  12. Photonuclear reactions of U-233 and Pu-239 near threshold induced by thermal neutron capture gamma rays

    International Nuclear Information System (INIS)

    Moraes, M.A.P. de.


    The photonuclear cross sections of U-293 and Pu-239 have been studied by using monochromatic and discrete photons, in the energy interval from 5.49 to 9.72 MeV, produced by thermal neutron capture. The gamma fluxes incident on the samples were measured using a ( 3 x 3 )'' NaI (TI) crystal. The photofission fragments were detected in Makrofol-Kg (SSNTD). A possible structure was observed in the U-233 cross sections, near 7.23 MeV. The relative fissionability of the nuclides was determined at each excitation energy and shown to be energy independent: ( 2.12 ± 0.25) for U-233 and ( 3.32 ± 0.41 ) for Pu-239. The angular distribution of photofission fragments of Pu-239 were measured at two mean excitation energies of 5.43 and 7.35 MeV. An anisotropic distribution of ( 12.2 ± 3.6 ) % was observed at 5.43 MeV. The total neutron cross sections were measured by using a long counter detector. The photoneutron cross sections were calculated by using energy dependent neutron multiplicities values, γ(E), obtained in the literature. The competition Γn/γf was also determined at each excitation energy, and shown to be energy independent: ( 0.54 ± 0.05 ) for U-233 and ( 0.44 ± 0.05 ) for Pu-239, and were correlated to the parameters Z sup(2)/A, ( Ef'-Bn'), A. According to the FUJIMOTO-YAMAGUCHI and CONSTANT NUCLEAR TEMPERATURE models, the nuclear temperatures were calculated. The total photoabsorption cross sections were also calculated as a sum of the photofission and photoneutron cross sections at each energy excitation. From these results the competition Γf/ΓA, called fission probability Pf, were obtained: ( 0.66 ± 0.02) for U-233 and ( 0.70 ± 0.02 ) for Pu-239. (author)

  13. Seafloor Observatory Science: a Review

    Directory of Open Access Journals (Sweden)

    L. Beranzoli


    Full Text Available The ocean exerts a pervasive influence on Earth’s environment. It is therefore important that we learn how this system operates (NRC, 1998b; 1999. For example, the ocean is an important regulator of climate change (e.g., IPCC, 1995. Understanding the link between natural and anthropogenic climate change and ocean circulation is essential for predicting the magnitude and impact of future changes in Earth’s climate. Understanding the ocean, and the complex physical, biological, chemical, and geological systems operating within it, should be an important goal for the opening decades of the 21st century. Another fundamental reason for increasing our understanding of ocean systems is that the global economy is highly dependent on the ocean (e.g., for tourism, fisheries, hydrocarbons, and mineral resources (Summerhayes, 1996. The establishment of a global network of seafloor observatories will help to provide the means to accomplish this goal. These observatories will have power and communication capabilities and will provide support for spatially distributed sensing systems and mobile platforms. Sensors and instruments will potentially collect data from above the air-sea interface to below the seafloor. Seafloor observatories will also be a powerful complement to satellite measurement systems by providing the ability to collect vertically distributed measurements within the water column for use with the spatial measurements acquired by satellites while also providing the capability to calibrate remotely sensed satellite measurements (NRC, 2000. Ocean observatory science has already had major successes. For example the TAO array has enabled the detection, understanding and prediction of El Niño events (e.g., Fujimoto et al., 2003. This paper is a world-wide review of the new emerging “Seafloor Observatory Science”, and describes both the scientific motivations for seafloor observatories and the technical solutions applied to their architecture. A

  14. Controllable Quantum States Mesoscopic Superconductivity and Spintronics (MS+S2006) (United States)

    Takayanagi, Hideaki; Nitta, Junsaku; Nakano, Hayato


    distance on the magnetization configuration of submicron-sized ferromagnetic rings / Tetsuya Miyawaki. A wide GaAs/GaAlAs quantum well simultaneously containing two dimensional electrons and holes / Ane Jensen. Simulation of the photon-spin quantum state transfer process / Yoshiaki Rikitake. Magnetotransport in two-dimensional electron gases on cylindrical surface / Friedland Klaus-Juergen. Full counting statistics for a single-electron transistor at intermediate conductance / Yasuhiro Utsumi. Creation of spin-polarized current using quantum point contacts and its detection / Mikio Eto. Density dependent electron effective mass in a back-gated quantum well / S. Nomura. The supersymmetric sigma formula and metal-insulator transition in diluted magnetic semiconductors / I. Kanazawa. Spin-photovoltaic effect in quantum wires / A. Fedorov -- Quantum interference. Nonequilibrium transport in Aharonov-Bohm interferometer with electron-phonon interaction / Akiko Ueda. Fano resonance and its breakdown in AB ring embedded with a molecule / Shigeo Fujimoto, Yuhei Natsume. Quantum resonance above a barrier in the presence of dissipation / Kohkichi Konno. Ensemble averaging in metallic quantum networks / F. Mallet -- Coherence and order in exotic materials. Progress towards an electronic array on liquid helium / David Rees. Measuring noise and cross correlations at high frequencies in nanophysics / T. Martin. Single wall carbon nanotube weak links / K. Grove-Rasmussen. Optical preparation of nuclear spins coupled to a localized electron spin / Guido Burkard. Topological effects in charge density wave dynamics / Toru Matsuura. Studies on nanoscale charge-density-wave systems: fabrication technique and transport phenomena / Katsuhiko Inagaki. Anisotropic behavior of hysteresis induced by the in-plane field in the v = 2/3 quantum Hall state / Kazuki Iwata. Phase diagram of the v = 2 bilayer quantum Hall state / Akira Fukuda -- Trapped ions (special talk). Quantum computation with trapped

  15. Cluster finds giant gas vortices at the edge of Earth's magnetic bubble (United States)


    first time that vortices are actually detected. When a KHI-wave rolls up into a vortex, it becomes known as a ‘Kelvin Cat’s eye’. The data collected by Cluster have shown density variations of the electrified gas, right at the magnetopause, precisely like those expected when travelling through a ‘Kelvin Cat’s eye’. Scientists had postulated that, if these structures were to form at the magnetopause, they might be able to pull large quantities of the solar wind inside the boundary layer as they collapse. Once the solar wind particles are carried into the inner part of the magnetosphere, they can be excited strongly, allowing them to smash into Earth’s atmosphere and give rise to the aurorae. Cluster’s discovery strengthens this scenario but does not show the precise mechanism by which the gas is transported into Earth’s magnetic bubble. Thus, scientists still do not know whether this is the only process to fill up the boundary layer when the magnetic fields are aligned. For those measurements, Hasegawa says, scientists will have to wait for a future generation of magnetospheric satellites. Notes for editors The results of this investigation have appeared in today’s issue of the scientific journal Nature, in a paper entitled ‘Transport of solar wind into Earth's magnetosphere through rolled-up Kelvin-Helmholtz vortices’, by H. Hasegawa, M. Fujimoto, T.D. Phan, H. Reme, A. Balogh, M.W. Dunlop, C. Hashimoto and R. TanDokoro. More about magnetic reconnection Solar wind particles follow ‘magnetic field lines’, rather like beads on a wire. The ‘doors’ that open in Earth’s magnetosphere during oppositely aligned magnetic configurations are caused by a phenomenon called ‘magnetic reconnection‘. During this process, Earth’s field lines spontaneously break and join themselves to the Sun’s, allowing the solar wind to pass freely into Earth’s magnetosphere. Magnetic reconnections are not possible in the aligned case, however, hence the

  16. FOREWORD: International determination of the Avogadro constant International determination of the Avogadro constant (United States)

    Massa, Enrico; Nicolaus, Arnold


    account; Zakel et al relate these measurements in detail. Next, Pramann et al illustrate how the molar mass of the enriched crystal was measured by exploiting isotopic enrichment and isotope dilution mass spectrometry. Valkiers et al report about remeasurement of the molar mass of a natural Si crystal, a measurement prompted by the exigency of clarifying the origin of the discrepancy between the NA value given in the present issue and the value obtained using natural Si crystals. A consistency analysis of the different isotopic-composition determinations is illustrated in the paper by Bulska et al. As reported in two papers by Massa et al, to determine the lattice parameter an x-ray interferometer was manufactured from the material between the already mentioned spheres. The measurement result was combined with lattice comparisons between different crystal samples and with the impurity gradient to extrapolate the sphere's lattice-parameter. Ferroglio et al's contribution analyzes the self-weight deformation of the x-ray interferometer. Fujimoto et al report about the lattice-perfection investigations carried out by a novel self-referencing diffractometer at the National Laboratory for High-Energy Physics (KEK) in Japan. A really great effort was made to characterize the sphere surfaces and to correct for the oxide layer and the contaminating atoms. The results of these investigations are given by Busch et al. The sphere diameter and topography were measured by optical interferometry to nanometer accuracy; the papers of Bartl et al and Kuramoto et al describe how the sphere volumes were determined. Andreas et al's paper describes the calculation of phase corrections for the diameter measurements. The results of mass comparisons against the Pt-Ir standards of the BIPM, NMIJ and PTB are given by Picard et al. The results reported in the present issue need to be completed. One of the necessary activities is to relate the mass of the 28Si atom to its Compton wavelength to test

  17. EDITORIAL: Announcing the 2005 Measurement Science and Technology Outstanding Paper Awards (United States)

    Foss, John; Dewhurst, Richard; Fujii, Kenichi; Regtien, Paul


    , whilst maintaining the linewidth of the seed laser source. Careful laboratory calibration tests are then described, showing benchmark results of sub-ppm sensitivity, and excellent system linearity up to 100 ppm. The final section describes the condition under which field tests were conducted, and validates the photoacoustic method by cross reference with both a Draeger sensor and an ion chromatograph. Overall, the paper possesses several innovative ideas. It is a well-structured paper, containing details of the instrumentation and techniques used. It has a careful discussion of the data and its validation, in order to realize the precision demonstrated. It is an innovative system required for a topical need within environmental protection. 2005 Award Winners—Precision Measurement The 2005 Measurement Science and Technology Outstanding Paper Award in the Precision Measurement category has been awarded to Ichiko Misumi, Satoshi Gonda, Qiangxian Huang, Taeho Keem, Tomizo Kurosawa (National Metrology Institute of Japan, National Institute of Advanced Industrial Science and Technology (NMIJ/AIST), Japan), Akihiro Fujii, Nahoko Hisata, Takeshi Yamagishi, Hirohisa Fujimoto (Olympus Corporation, Japan), Ken Enjoji (Olympus Systems Corporation, Japan), Sunao Aya and Hiroaki Sumitani (Mitsubishi Electric Corporation, Japan) for the article 'Sub-hundred nanometre pitch measurements using an AFM with differential laser interferometers for designing usable lateral scales', published in volume 16, issue 10, pp 2080 2090. In making their recommendation the Precision Measurements working group chaired by Dr Kenichi Fujii gave the following endorsement: This paper describes a new instrument developed for measuring the pitches of one-dimensional grating standards. In the field of nanotechnology and in the semiconductor industry, reliable one-dimensional grating standards have been solicited for calibrating length measurement in nanometre regions. In the instrument described here, an

  18. Autologous Immune Enhancement Therapy for Cancer - Our experience since 2004

    Directory of Open Access Journals (Sweden)

    Hiroshi Terunuma


    T-lymphocyte immunotherapy for ovarian cancer: a pilot study. J Immunother. 2012 Feb-Mar;35(2:196-204.7.Iliopoulou EG, Kountourakis P, Karamouzis MV, Doufexis D, Ardavanis A, Baxevanis CN, Rigatos G, Papamichail M, Perez SA. A phase I trial of adoptive transfer of allogeneic natural killer cells in patients with advanced non-small cell lung cancer. Cancer Immunol Immunother. 2010 Dec;59(12:1781-9.8.Leemhuis T, Wells S, Scheffold C, Edinger M, Negrin RS. A phase I trial of autologous cytokine-induced killer cells for the treatment of relapsed Hodgkin disease and non-Hodgkin lymphoma. Biol Blood Marrow Transplant. 2005 Mar;11(3:181-7.9.Abraham S. Academic Serendipity to clinical, commercial success. Trade Secrets - Nature Biotech Blog. 2011 Sep. 10.Terunuma H, Deng X, Dewan Z, Fujimoto S, Yamamoto N. Potential role of NK cells in the induction of immune responses: Implications for NK cell-based immunotherapy for cancers and viral infections. Int Rev Immunol 2008; 27: 93-110 11.Takada M, Terunuma H, Deng X, Dewan MZ, Saji S, Kuroi K, Yamamoto N, Toi M. Refractory lung metastasis from breast cancer treated with multidisciplinary therapy including an immunological approach. Breast Cancer 18:64-7, 2011. 12.Dewan MZ, Takada M, Terunuma H, Deng X, Ahmed S, Yamamoto N, Toi M. Natural killer activity of peripheral-blood mononuclear cells in breast cancer patients. Biomed Pharmacother 63:703-6, 2009.13.Dedeepiya V, Terunuma H, Deng X, Baskar S, Manjunath S, Senthilkumar R, Murugan P, Thamaraikannan P, Srinivasan T, Preethy S, Abraham S. A comparative analysis of in vitro expansion of natural killer cells of a patient with autoimmune haemolytic anaemia and ovarian cancer with patients with other solid tumours.Oncology Letters. 2011;3(2. Doi: 10.3892/ol.2011.498; 14.Deng X, Terunuma H, Nieda M, Xiao W, Nicol A. Synergistic cytotoxicity of ex vivo expanded natural killer cells in

  19. Selective Photonic Disinfection; A ray of hope in the war against pathogens (United States)

    Tsen, Shaw-Wei D.; Tsen, Kong-Thon


    -type="journal"> Gaffney K J Davis P H Piletic I R Levinger N E Fayer M D 2002 Hydrogen bond dissociation and reformation in methanol oligomers following hydroxyl stretch relaxation J. Phys. Chem. A 106 12012 12023 12012-23 10.1021/jp021696g citation> 5 citation publication-type="journal"> O'Connell C Sherlock R Ball M D Aszalos-Kiss B Prendergast U Glynn T J 2009 Investigation of the hydrophobic recovery of various polymeric biomaterials after 172 nm UV treatment using contact angle, surface free energy and XPS measurements Appl. Surf. Sci. 255 4405 4413 4405-13 10.1016/j.apsusc.2008.11.034 citation> 1 citation publication-type="journal"> Dykeman E C Sankey O F 2010 Atomistic modeling of the low-frequency mechanical modes and Raman spectra of icosahedral virus capsids Phys. Rev. E 81 021918 10.1103/PhysRevE.81.021918 citation> 2 citation publication-type="journal"> Yan Y X Gamble E B Nelson K A 1985 Impulsive stimulated scattering: general importance in femtosecond laser pulse interactions with matter, and spectroscopic applications J. Chem. Phys. 83 5391 5399 5391-9 10.1063/1.449708 citation> 3 citation publication-type="book"> Tsen K T Dykeman E C Sankey O F Tsen S W D Kiang J G 2009 Contemporary Trends in Bacteriophage Research Adams H T Hauppauge, NY Nova Science Publishers pp 151 177 151-77 citation> 4 citation publication-type="book"> Arfken G 1970 Mathematical Methods for Physicists 2nd edn New York Academic citation> 5 citation publication-type="book"> Davydov A S 1965 Quantum Mechanics Palo Alto, CA Addison-Wesley citation> 6 citation publication-type="journal"> Nelson K A Miller R J D Lutz D R Fayer M D 1982 Optical generation of tunable ultrasonic waves J. Appl. Phys. 53 1144 1149 1144-9 10.1063/1.329864 citation> 7 citation publication-type="journal"> De Silvestri S Fujimoto J G Ippen E P 1985 Femtosecond time-resolved measurements of optic phonon dephasing by impulsive stimulated Raman scattering in α-perylene crystal from 20 to 300 K Chem. Phys. Lett. 116 146 152 146-52 10